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[ [ "COMPOSITIONS AND METHODS INVOLVING POLYMER, SOLVENT, AND HIGH VISCOSITY LIQUID CARRIER MATERIAL", "Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent.", "Related compositions and methods are also disclosed." ], [ "1.A composition comprising: 5 wt % to 20 wt %, based on total weight of the composition, of particles comprising pharmaceutical active agent that is risperidone or pharmaceutically acceptable salt thereof, the particles having a median particle size, as measured by laser diffraction, ranging from 0.5 micrometer to 7 micrometers; 30 wt % to 60 wt %, based on total weight of the composition, of a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere, wherein the HVLCM is sucrose acetate isobutyrate; 5 wt % to 30 wt %, based on total weight of the composition, of a lactic acid based-polymer that is poly(lactic acid)(glycolic acid) comprising an alkoxy end group, the poly(lactic acid)(glycolic acid) having a lactic acid to glycolic acid molar ratio ranging from 95:5 to 60:40, the poly(lactic acid)(glycolic acid) having a weight average molecular weight ranging from 4000 Daltons to 15,000 Daltons; and 10 wt % to 40 wt %, based on total weight of the composition, of a solvent that is at least one member selected from N-methyl-pyrrolidone, propylene carbonate, and dimethylsulfoxide.", "2.The composition of claim 1, which is a gamma-irradiated composition.", "3.The composition of claim 1, wherein a weight ratio of the HVLCM to the lactic acid-based polymer to the solvent ranges from 1:0.25-0.5:0.4-0.8.4.The composition of claim 1, wherein the composition has a viscosity ranging from 50 cP to 2000 cP.", "5.The composition of claim 1, wherein the alkoxy end group consists of 8 to 24 carbons.", "6.The composition of claim 5, wherein the alkoxy end group consists of 12 carbons.", "7.The composition of claim 5, wherein the lactic acid-based polymer is initiated with a fatty alcohol.", "8.The composition of claim 5, wherein the lactic-acid based polymer is initiated with dodecanol.", "9.The composition of claim 1, wherein the solvent comprises N-methyl-pyrrolidone.", "10.The composition of claim 1, wherein the solvent comprises propylene carbonate.", "11.The composition of claim 1, wherein the solvent comprises dimethylsulfoxide.", "12.The composition of claim 2, wherein the solvent comprises N-methyl-pyrrolidone.", "13.The composition of claim 2, wherein the solvent comprises propylene carbonate.", "14.The composition of claim 2, wherein the solvent comprises dimethylsulfoxide.", "15.The composition of claim 4, wherein the solvent comprises N-methyl-pyrrolidone.", "16.The composition of claim 4, wherein the solvent comprises propylene carbonate.", "17.The composition of claim 4, wherein the solvent comprises dimethylsulfoxide.", "18.The composition of claim 5, wherein the solvent comprises N-methyl-pyrrolidone.", "19.The composition of claim 5, wherein the solvent comprises propylene carbonate.", "20.The composition of claim 5, wherein the solvent comprises dimethylsulfoxide." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>The present disclosure is further described in the description that follows, in reference to the noted plurality of non-limiting drawings, wherein: FIG.", "1 presents a longitudinal cross-section through a needle-free injector.", "FIGS.", "2 a, b and c show the latch 6 and dispensing member 2 part of the needle-free injector from FIG.", "1 in the three stages ending in triggering.", "In (a) the latch 6 is in the first, or safe position.", "In (b) the latch 6 is in the second position, the non-safety, ready to trigger position.", "In (c), the latch 6 is in the third position, following triggering.", "FIG.", "3 illustrates a needle-free injector with one embodiment of the attachment for disengaging the safety mechanism.", "FIG.", "4 is a phase diagram of compositions including 65:35 DL-PLGA initiated with 1-hexanediol, which polymer has a weight average molecular weight of 4.3 to 5.1 kDa.", "FIG.", "5 is a phase diagram of compositions including 65:35 DL-PLGA initiated with 1-hexanediol, which polymer has a weight average molecular weight of 7.0 kDa.", "FIG.", "6 is a phase diagram of compositions including 65:35 DL-PLGA initiated with dodecanol, which polymer has a weight average molecular weight of 6.6 kDa.", "FIG.", "7 shows in vitro release, as measured using dialysis tubing, of olanzapine from various vehicles.", "FIG.", "8 shows in vitro release, as measured using dialysis tubing and a USP 2 apparatus, of olanzapine from a vehicle comprising sucrose acetate isobutyrate, propylene carbonate, and dodecanol-initiated poly(lactic acid)(glycolic acid).", "FIG.", "9 shows in vitro release, as measured using dialysis tubing and a USP 2 apparatus, of olanzapine from a vehicle comprising sucrose acetate isobutyrate, di methylsulfoxide, and dodecanol-initiated poly(lactic acid)(glycolic acid).", "FIG.", "10 shows in vitro release of exenatide from a vehicle comprising sucrose acetate isobutyrate, propylene carbonate, and poly(lactic acid)(glycolic acid) initiated with either octanol or 1-hexadecanol.", "FIG.", "11 shows in vitro release of exenatide from a vehicle comprising sucrose acetate isobutyrate, dimethylsulfoxide, and poly(lactic acid)(glycolic acid) initiated with either octanol or 1-hexadecanol.", "FIG.", "12 compares the real time settling behavior of risperidone particles in a composition based on N-methyl-pyrrolidone versus a composition based on propylene carbonate, both stored at 5° C. FIG.", "13 shows in vitro release of risperidone from a vehicle comprising sucrose acetate isobutyrate, N-methyl-pyrrolidone, and octanol-initiated poly(lactic acid)(glycolic acid).", "FIG.", "14 shows in vitro release of risperidone from a vehicle comprising sucrose acetate isobutyrate, N-methyl-pyrrolidone, and hexadecanol-initiated poly(lactic acid)(glycolic acid).", "FIG.", "15 shows in vitro release of risperidone from a vehicle comprising sucrose acetate isobutyrate, N-methyl-pyrrolidone, and dodecanol-initiated poly(lactic acid).", "FIG.", "16 shows the PK profile of risperidone in rats from compositions comprising risperidone, sucrose acetate isobutyrate, solvent (e.g., benzyl alcohol, ethanol, benzyl benzoate, and N-methyl-pyrrolidone), and polymer (e.g., poly(lactic acid) (PLA) and poly(lactic acid)(glycolic acid) (PLGA)).", "FIG.", "17 shows the active moiety (risperidone 9-hydroxy risperidone) PK profile following subcutaneous (SC) administration of the compositions shown in FIG.", "16 .", "FIG.", "18 shows the PK profile of risperidone in individual rats following SC administration of one of the risperidone compositions shown in FIG.", "16 .", "FIG.", "19 shows the molecular weight of polymer with respect to storage time in compositions with or without risperidone and with or without gamma radiation treatment.", "FIG.", "20 shows the PK profile of risperidone in rats from compositions comprising risperidone, sucrose acetate isobutyrate, solvent (N-methyl-pyrrolidone or dimethylsulfoxide), dodecanol-initiated poly(lactic acid)(glycolic acid), and optionally poly(lactic acid).", "FIG.", "21 shows the active moiety (risperidone+9-hydroxy risperidone) PK profile following SC administration of the compositions shown in FIG.", "20 .", "FIG.", "22 shows the active moiety PK profile of individual rats following SC administration of one of the risperidone compositions shown in FIG.", "21 .", "FIG.", "23 compares the PK profile of risperidone in rats from three compositions: (1) made with large particle risperidone and a vehicle including hexanediol-initiated poly(lactic acid)(glycolic acid) (PLGA); (2) made with small particle risperidone and a vehicle including hexanediol-initiated PLGA; and (3) made with small particle risperidone and a vehicle including dodecanol-initiated PLGA.", "FIG.", "24 is an expanded view of a portion of FIG.", "23 .", "FIG.", "25 involves the same experiment as shown in FIGS.", "23 and 24 , and compares the AUC from compositions: (1) made with small particle risperidone and a vehicle including hexanediol-initiated PLGA; and (2) made with small particle risperidone and a vehicle including dodecanol-initiated PLGA.", "FIG.", "26 shows pharmacokinetic profiles in dogs following SC administration of a 9 wt % risperidone composition.", "FIG.", "27 shows the effect of particle size on PK profile in dogs.", "FIG.", "28 shows the PK profile when 25 mg of risperidone in a vehicle comprising sucrose acetate isobutyrate (SAIB) was administered as a SC injection of 0.25 mL (100 mg/mL concentration) in the abdominal region of humans.", "FIG.", "29 shows the PK profile when 50 mg of risperidone in the SAIB based vehicle was administered via a DosePro® needle-free injector of 0.5 mL (100 mg/mL concentration) in the abdominal region of humans.", "FIG.", "30 shows the PK profile when 50 mg of risperidone in the SAIB based vehicle was administered as a subcutaneous (SC) injection of 0.5 mL (100 mg/mL concentration) in the abdominal region of humans.", "detailed-description description=\"Detailed Description\" end=\"lead\"?", "Unless otherwise stated, a reference to a compound or component includes the compound or component by itself, as well as in combination with other compounds or components, such as mixtures of compounds: As used herein, the singular forms “a,” “an,” and “the” include the plural reference unless the context clearly dictates otherwise.", "Before further discussion, a definition of the following terms will aid in the understanding of the present disclosure.", "“Administering” or “administration” means providing a drug to a subject in a manner that is pharmacologically useful.", "“Polymer” means a naturally occurring or synthetic compound made up of a linked series of repeat units.", "Polymer(s) include, but are not limited to, thermoplastic polymers and thermoset polymers.", "Polymer(s) may comprise linear polymers and/or branched polymers.", "Polymers may be synthesized from a single species of monomers, or may be copolymers that may be synthesized from more than one species of monomers.", "“Copolymer” includes terpolymers, etc.", "“Linear” means a polymer in which the molecules form long chains substantially without branches or cross-linked structures.", "“Weight average molecular weight” or “Mw” means the weighted average molecular weight of polymers of interest.", "It can be expressed at the first moment of a plot of the weight of polymer in each molecular weight range against molecular weight.", "In certain embodiments, weight-average molecular weight, Number-average molecular weight (Mn), and the molecular weight distribution (MWD=Mw/Mn) may be measured by gel permeation chromatography (GPC).", "GPC is a column fractionation method wherein polymer molecules in solutions are separated based on their sizes.", "The separated polymer molecules are observed by a detector to generate the GPC chromatogram, which is a plot of elution volume or time (related to molecular size) versus abundance.", "The GPC chromatogram may be integrated to determine Mw, Mn, and MWD.", "GPC samples of polymer(s) of interest, approximately 50 mg in 10 mL solvent, are filtered through a 0.2 μm Teflon filter before injection into the instrument.", "Injections of 50-200 μL are made to generate chromatograms.", "Chromatograms may be generated using various systems.", "In an embodiment, a system comprises an Agilent LC 1100 using Chemstation software.", "In another embodiment, a system comprises a Waters 510 pump, a Shimadzu CTO-10A column oven, and a Waters 410 differential refractometer.", "Data may be recorded directly to a PC via a Polymer Labs data capture unit using Caliber® software.", "A calibration curve may be generated using polystyrene standards.", "Mw, Mn, and MWD relative to polystyrene are calculated.", "Representative solvents for use in GPC comprise: chloroform, dichlormethane (methylene chloride), and tetrahydrofuran (THF).", "Representative column sets comprise: (1) two Polymer Labs Mixed C columns in series, (2) two Polymer Labs Mixed D columns in series, or (3) two Polymer Labs Mesopore columns in series.", "Representative polystyrene calibrants comprise: Polymer Labs Easical PS1 kit, Polymer Labs Easical PS2 kit, Polymer Labs S-L-10 kit.", "“Solvent” means material that is capable of dissolving other materials.", "“Solvent capacity” means amount(s) of the one or more solvents that dissolves the HVLCM and polymer in the composition to the same extent as would a hypothetical amount of N-methylpyrrolidone in the composition.", "Solvent capacity is expressed as that hypothetical weight percent of N-methylpyrrolidone in the composition, based on the total weight of the hypothetical composition that would contain the N-methylpyrrolidone.", "Thus, for example, a composition having a solvent capacity of about 20% would have sufficient amounts of one or more solvents to dissolve the HVLCM and linear polymer to the same extent as if about 20% by weight of NMP were added to the composition instead of the one or more solvents.", "If NMP were present as the one or more solvents in this embodiment, it would be present in an amount of about 20% by weight, based on the total weight of the composition.", "If the one or more solvents were poorer solvents for the HVLCM and linear polymer, then the one or more solvents would be present in an amount greater than about 20% by weight, based on the total weight of the composition.", "“Subject” is used interchangeably with “individual” and means any human or animal with which it is desired to practice the present disclosure.", "The term “subject” does not denote a particular age, and the present systems are thus suited for use with subjects of any age, such as infant, adolescent, adult and senior aged subjects In certain embodiments, a subject may comprise a patient.", "“Hydrophilic solvent” means substantially water-miscible solvents, preferably those when mixed with water in a ratio from 1:9 to 9:1 form a single-phase solution.", "In one aspect, the present composition comprises 25 wt % to 80 wt %, based on total weight of the composition, of a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere; a lactic-acid based polymer that is poly(lactic acid)(glycolic acid) comprising an alkoxy end group, the poly(lactic acid)(glycolic acid) having a lactic acid to glycolic acid molar ratio greater than 65:35; and an organic solvent.", "In another aspect, the present composition comprises 25 wt % to 80 wt %, based on total weight of the composition, of a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere; a lactic acid-based polymer comprising an alkoxy end group, wherein the lactic acid-based polymer has a weight average molecular weight ranging from 7000 Daltons to 30,000 Daltons; and an organic solvent.", "In yet another aspect, the present composition comprises a pharmaceutical active agent; 25 wt % to 80 wt %, based on total weight of the composition, of a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere; a lactic acid-based polymer comprising an alkoxy end group; and an organic solvent.", "In still another aspect, the present composition comprises particles comprising pharmaceutical active agent, the particles having a median particle size, as measured by laser diffraction, ranging from 0.5 micrometers to 10 micrometers; 25 wt % to 80 wt %, based on total weight of the composition, of a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere; a lactic acid-based polymer; and an organic solvent.", "In a further aspect, a gamma-irradiated composition comprises pharmaceutical active agent; and wherein the gamma-irradiated composition further comprises 25 wt % to 80 wt %, based on total weight of the composition, of a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere; a lactic acid-based polymer; and an organic solvent.", "In another aspect, the present composition comprises a pharmaceutical active agent that is risperidone or pharmaceutically acceptable salt thereof; a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere, a lactic acid-based polymer comprising an alkoxy end group, and an organic solvent in a ratio sufficient to maintain a therapeutically effective plasma concentration of the risperidone or pharmaceutically acceptable salt thereof for a period of at least 7 days when the composition is administered parenterally to a patient.", "In still another aspect, the present composition comprises a pharmaceutical active agent that is risperidone or pharmaceutically acceptable salt thereof; a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere, a lactic acid-based polymer comprising an alkoxy end group, and an organic solvent in a ratio such that when the composition is administered parenterally, an amount of pharmaceutical active agent released from the composition provides an AUC(0 to 1 day) that is less than 10%, such as less than 5%, of AUC(0 to 28 days).", "In a further aspect, the present composition comprises 5 wt % to 20 wt %, based on total weight of the composition, of particles comprising pharmaceutical active agent that is risperidone or pharmaceutically acceptable salt thereof, the particles having a median particle size, as measured by laser diffraction, ranging from 0.5 micrometer to 7 micrometers; 30 wt % to 60 wt %, based on total weight of the composition, of a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere, wherein the HVLCM is sucrose acetate isobutyrate; 5 wt % to 30 wt %, based on total weight of the composition, of a lactic acid based-polymer that is poly(lactic acid)(glycolic acid) comprising an alkoxy end group, the poly(lactic acid)(glycolic acid) having a lactic acid to glycolic acid molar ratio ranging from 95:5 to 60:40, the poly(lactic acid)(glycolic acid) having a weight average molecular weight ranging from 4000 Daltons to 15,000 Daltons; and 10 wt % to 40 wt %, based on total weight of the composition, of a solvent that is at least one member selected from N-methyl-pyrrolidone, propylene carbonate, and dimethylsulfoxide.", "In another aspect, the present composition comprises a pharmaceutical active agent that is risperidone or pharmaceutically acceptable salt thereof; means for extending a release profile of the pharmaceutical active agent when the composition is administered to a patient in need thereof.", "In a still further aspect, the present composition comprises a pharmaceutical active agent that is risperidone or pharmaceutically acceptable salt thereof; means for reducing settling of the pharmaceutical active agent within the composition.", "In another aspect, the present disclosure involves a method of reducing phase separation, comprising combining a pharmaceutical active agent with a means for achieving the reduction of phase separation.", "In a further aspect, the present disclosure involves a process comprising: wet milling a pharmaceutical active agent in an aqueous solution at less than 20° C. to form a milled pharmaceutical active agent; maintaining the milled pharmaceutical active agent at less than 5° C.; and lyophilizing the milled pharmaceutical active agent to form a lyophilized pharmaceutical active agent having a median particle size, as measured by laser diffraction, of less than 5 micrometers.", "In another aspect, a suspension is produced by wet milling a pharmaceutical active agent in an aqueous solution at less than 20° C. to form a milled pharmaceutical active agent; maintaining the milled pharmaceutical active agent at less than 5° C.; and lyophilizing the milled pharmaceutical active agent to form a lyophilized pharmaceutical active agent having a median particle size, as measured by laser diffraction, of less than 5 micrometers.", "In another aspect, a monophasic composition, comprises 25 wt % to 80 wt %, based on total weight of the composition, of sucrose acetate isobutyrate; a poly(lactic acid)(glycolic acid) comprising an alkoxy end group wherein the alkoxy end group consists of 12 carbons, the poly(lactic acid)(glycolic acid) having a lactic acid to glycolic acid molar ratio of at least 70:30; and an organic solvent that maintains the composition monophasic at 25° C. and 1 atmosphere.", "The pharmaceutical active agent may be dissolved or suspended in the composition.", "The particles comprising pharmaceutical active agent, which are used to make the disclosed compositions, typically have a median particle size, as measured by laser diffraction, ranging from 0.1 micrometer to 100 micrometers, such as 0.25 micrometers to 50 micrometers, 0.5 micrometers to 10 micrometers, 0.5 micrometer to 7 micrometers, or 1 micrometer to 5 micrometers.", "When particles are relatively large, e.g., median particle size, as measured by laser diffraction, above 10 micrometers, the particles have a tendency to fall out of suspension in lower viscosity formulations.", "When particles are relatively small, the particle size may change due to recrystallization, which affects the storage time dependence of the release profile.", "In the context of the present disclosure, the median particle size, as measured by laser diffraction, refers to the size of the particles before addition with the vehicle.", "Thus, the recited compositions are “made from” or “obtainable by combining” the particles comprising the pharmaceutical active agent and the one or more further specified components.", "In some cases, the pharmaceutical active agent has a solubility in the composition at 25° C. of less than about 100 mg/mL, such as less than about 50 mg/mL, less than about 10 mg/mL, less than about 5 mg/mL, less than about 1 mg/mL, or less than about 0.1 mg/mL.", "In one aspect, the pharmaceutical active agent comprises at least one member selected from peptide, protein, antibody, carbohydrate, small molecule, nucleic acid, and nucleoside.", "Representative pharmaceutical active agents include drug, peptide, protein, carbohydrate (including monosaccharides, oligosaccharides, and polysaccharides), nucleoprotein, mucoprotein, lipoprotein, synthetic polypeptide or protein, or a small molecule linked to a protein, antibody, glycoprotein, steroid, nucleic acid (any form of DNA, including cDNA, or RNA, or a fragment thereof), nucleotide, nucleoside, oligonucleotides (including antisense oligonucleotides), gene, lipid, hormone, mineral supplement, vitamin including vitamin C and vitamin E, or combinations of any of the above, that cause(s) a biological effect when administered in vivo to an animal, including but not limited to birds and mammals, including humans.", "Drug means any substance used internally or externally as a medicine for the treatment, cure, or prevention of a disease or disorder, and includes but is not limited to immunosuppressants, antioxidants, anesthetics, chemotherapeutic agents, steroids (including retinoids), hormones, antibiotics, antivirals, antifungals, antiproliferatives, antihistamines, anticoagulants, antiphotoaging agents, melanotropic peptides, nonsteroidal and steroidal anti-inflammatory compounds, antipsychotics, and radiation absorbers, including UV-absorbers.", "In one embodiment disclosed herein, the pharmaceutical active agent is a vaccine and the substance to be delivered is an antigen.", "The antigen can be derived from a cell, bacteria, or virus particle, or portion thereof.", "As defined herein, antigen may be a protein, peptide, polysaccharide, glycoprotein, glycolipid, nucleic acid, or combination thereof, which elicits an immunogenic response in an animal, for example, a mammal, bird, or fish.", "As defined herein, the immunogenic response can be humoral or cell-mediated.", "In the event the material to which the immunogenic response is to be directed is poorly antigenic, it may be conjugated to a carrier such as albumin or to a hapten, using standard covalent binding techniques, for example, with one of the several commercially available reagent kits.", "Examples of antigens include viral proteins such as influenza proteins, human immunodeficiency virus (HIV) proteins, and hepatitis A, B, or C proteins, and bacterial proteins, lipopolysaccharides such as gram negative bacterial cell walls and Neisseria gonorrhea proteins, and parvovirus.", "Non-limiting examples of pharmaceutical active agents include anti-infectives such as nitrofurazone, sodium propionate, antibiotics, including penicillin, tetracycline, oxytetracycline, chlorotetracycline, bacitracin, nystatin, streptomycin, neomycin, polymyxin, gramicidin, chloramphenicol, erythromycin, and azithromycin; sulfonamides, including sulfacetamide, sulfamethizole, sulfamethazine, sulfadiazine, sulfamerazine, and sulfisoxazole, and anti-virals including idoxuridine; antiallergenics such as antazoline, methapyritene, chlorpheniramine, pyrilamine prophenpyridamine, hydrocortisone, cortisone, hydrocortisone acetate, dexamethasone, dexamethasone 21-phosphate, fluocinolone, triamcinolone, medrysone, prednisolone, prednisolone 21-sodium succinate, and prednisolone acetate; desensitizing agents such as ragweed pollen antigens, hay fever pollen antigens, dust antigen and milk antigen; vaccines such as smallpox, yellow fever, distemper, hog cholera, chicken pox, antivenom, scarlet fever, dyptheria toxoid, tetanus toxoid, pigeon pox, whooping cough, influenzae, rabies, mumps, measles, poliomyelitic, and Newcastle disease; decongestants such as phenylephrine, naphazoline, and tetrahydrazoline; miotics and anticholinesterases such as pilocarpine, esperine salicylate, carbachol, diisopropyl fluorophosphate, phospholine iodide, and demecarium bromide; parasympatholytics such as atropine sulfate, cyclopentolate, homatropine, scopolamine, tropicamide, eucatropine, and hydroxyamphetamine; sympathomimetics such as epinephrine; sedatives and hypnotics such as pentobarbital sodium, phenobarbital, secobarbital sodium, codeine, (a-bromoisovaleryl) urea, carbromal; psychic energizers such as 3-(2-aminopropyl) indole acetate and 3-(2-aminobutyl) indole acetate; tranquilizers such as reserpine, chlorpromayline, and thiopropazate; androgenic steroids such as methyl-testosterone and fluorymesterone; estrogens such as estrone, 17-.beta.-estradiol, ethinyl estradiol, and diethyl stilbestrol; progestational agents such as progesterone, megestrol, melengestrol, chlormadinone, ethisterone, norethynodrel, 19-norprogesterone, norethindrone, medroxyprogesterone and 17-.beta.-hydroxy-progesterone; humoral agents such as the prostaglandins, for example PGE.sub.1, PGE.sub.2 and PGF.sub.2; antipyretics such as aspirin, sodium salicylate, and salicylamide; antispasmodics such as atropine, methantheline, papaverine, and methscopolamine bromide; antimalarials such as the 4-aminoquinolines, 8-aminoquinolines, chloroquine, and pyrimethamine, antihistamines such as diphenhydramine, dimenhydrinate, tripelennamine, perphenazine, and chlorphenazine; cardioactive agents such as dibenzhydroflume thiazide, flumethiazide, chlorothiazide, and aminotrate; antipsychotics including typical and atypical antipsychotics, wherein the atypical antipsychotics comprise risperidone, paliperidone, or olanzapine; nutritional agents such as vitamins, natural and synthetic bioactive peptides and proteins, including growth factors, cell adhesion factors, cytokines, and biological response modifiers; together with pharmaceutically acceptable salts of the above.", "The pharmaceutical active agent is typically included in the composition in an amount sufficient to deliver to the host animal or plant an effective amount to achieve a desired effect.", "The amount of pharmaceutical active agent incorporated into the composition depends upon the desired release profile, the concentration of pharmaceutical active agent required for a biological effect, and the desired period of release of the pharmaceutical active agent.", "The concentration of pharmaceutical active agent in the composition will also depend on absorption, inactivation, and excretion rates of the pharmaceutical active agent as well as other factors known to those of skill in the art.", "It is to be noted that dosage values will also vary with the severity of the condition to be alleviated.", "It is to be further understood that for any particular subject, specific dosage regimens should be adjusted over time according to the individual need and the professional judgment of the person administering or supervising the administration of the disclosed compositions, and that the concentration ranges set forth herein are exemplary only and are not intended to limit the scope or practice of the present disclosure.", "The compositions may be administered in one dosage, or may be divided into a number of smaller doses to be administered at varying intervals of time.", "In some cases, the pharmaceutical active agent comprises an antipsychotic, such as an atypical antipsychotic.", "Examples of anti-psychotic drugs include, but are not limited to metabotropic glutamate receptor 2 agonists, glycine transporter 1 inhibitors, partial agonists of dopamine receptors, chlorpromazine, fluphenazine, mesoridazine, perphenazine, prochlorperazine, promazine, thioridazine/sulforidazine, trifluoperazine, butyrophenones (azaperone, benperidol, droperidol, haloperidol), thioxanthenes (flupentixol, chlorprothixene, thiothixene, zuclopenthixol), diphenylbutylpiperidines (fluspirilene, penfluridol, pimozide, loxapine), butyrophenones (melperone), indoles (sertindole, ziprasidone, molidone), benzamides (sulpiride, remoxipride, amisulpride), diazepines/oxazepines/thiazepines (clozapine, olanzapine, quetiapine), aripiprazole, risperidone, paliperidone, zotepine), amisulpride, asenapine, iloperidone, lurasidone, cannabidiol, tetraenazine, and L-theanine, including pharmaceutically acceptable salts, solvates, bases, and ester forms thereof.", "Combinations of two or more of these compounds, or combinations with other compounds are included in the scope of the disclosure.", "For instance, the pharmaceutical active agent may comprise at least one member selected from chlorpromazine, fluphenazine, mesoridazine, perphenazine, prochlorperazine, promazine, thioridazine, sulforidazine, trifluoperazine, molindone, azaperone, benperidol, droperidol, haloperidol, flupentixol, chlorprothixene, thiothixene, zuclopenthixol, fluspirilene, penfluridol, pimozide, loxapine, melperone, sertindole, ziprasidone, sulpiride, remoxipride, amisulpride, clozapine, olanzapine, quetiapine, aripiprazole, risperidone, paliperidone, zotepine, amisulpride, asenapine, iloperidone, lurasidone, cannabidiol, tetraenazine, and L-theanine, or pharmaceutically acceptable salt thereof.", "In some cases, the pharmaceutical active agent comprises risperidone or pharmaceutically acceptable salt thereof.", "Exemplary salts include hydrochloride, phosphate, citrate, maleate, mesylate, pamoate, and naphthaline-2-sulfonate monohydrate.", "For instance, representative salts include risperidone pamoate, risperidone naphthaline-2-sulfonate, paliperidone palmitate.", "In some cases, the salt is lipophilic.", "The pharmaceutical active agent is typically present in the compositions in the range from 0.5 wt % to 50 wt %, such as 0.5 wt % to 30 wt %, 1 wt % to 25 wt %, 1 wt % to 20 wt %, 2 wt % to 20 wt %, or 5 wt % to 20 wt %, based on total weight of the composition.", "For potent pharmaceutical active agents, such as growth factors, typical ranges include less than 1 wt %, and further even less than 0.0001 wt %.", "The compositions can include one or more non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere.", "For instance, the HVLCM may have a viscosity of at least at least 10,000 cP, at least 15,000 cP, at least 20,000 cP, at least 25,000 cP, or at least 50,000 cP at 37° C. The term non-water soluble refers to a material that is soluble in water to a degree of less than one percent by weight under ambient conditions.", "In some cases, the HVLCM significantly decreases in viscosity when mixed with a solvent to form a low viscosity liquid carrier material (“LVLCM”) that can be mixed with a substrate for controlled delivery.", "The LVLCM/substrate composition is typically easier to place in the body than a HVLCM/substrate composition, because it flows more easily into and out of syringes or other implantation means, and can easily be formulated as an emulsion.", "The LVLCM can have any desired viscosity.", "It has been found that a viscosity range for the LVLCM of less than approximately 2000 cP, such as less than 1000 cP, is typically useful for in vivo applications.", "In one embodiment, sucrose acetate isobutyrate (“SAIB”), a sucrose molecule nominally esterified preferably with two acetic acid and six isobutyric acid moieties, is used as the HVLCM.", "SAIB is orally non-toxic and is currently used as to stabilize emulsions in the food industry.", "It is a very viscous liquid and has an unusual property that there is a dramatic change in viscosity with small additions of heat or with the addition of solvents.", "It is soluble in a large number of biocompatible solvents.", "When in solution or in an emulsion, SAIB can be applied via injection or an aerosol spray.", "SAIB is compatible with cellulose esters and other polymers that can affect the rate of delivery of the substance.", "In some embodiments of the disclosure, the HVLCM can be stearate esters such as those of propylene glycol, glyceryl, diethylaminoethyl, and glycol, stearate amides and other long-chain fatty acid amides, such as N,N′-ethylene distearamide, stearamide MEA and DEA, ethylene bistearamide, cocoamine oxide, long-chain fatty alcohols, such as cetyl alcohol and stearyl alcohol, long-chain esters such as myristyl myristate, beheny erucate, and glyceryl phosphates.", "In a particular embodiment, the HVLCM is acetylated sucrose distearate (Crodesta A-10).", "Additional materials suitable for use as the HVLCM are disclosed in US Patent Application Publication US 2004/0101557 by Gibson et al.", "The amount of HVLCM in a composition will depend on the desired properties of a composition and the solvent capacity of the chosen solvent.", "If the chosen solvent has poor solvent capacity performance, then the actual amount of solvent may be large, with a corresponding reduction in the amount of HVLCM in the composition.", "The HVLCM is typically present in controlled delivery compositions in an amount ranging from about 10 wt % to about 99.5 wt %, such as from 25 wt % to 95 wt %, from 25 wt % to 85 wt %, from 30 wt % to 60 wt %, and from 45 wt % to 55 wt %, relative to the total weight of the composition.", "The compositions can include one or more polymer, such as a lactic-acid based polymer.", "The lactic-acid based polymer is typically biodegradable and biocompatible.", "The lactic-acid based polymer can be used to alter the release profile of the pharmaceutical active agent to be delivered, to add integrity to the composition, or to otherwise modify the properties of the composition.", "An exemplary property of the composition is the miscibility or solubility of the polymer in the composition with the HVLCM.", "In situations where the polymer is not miscible or soluble in the composition with the HVLCM, phase separation of the polymer and the HVLCM may occur.", "Once this occurs, it may be very difficult to remix the polymer and the HVLCM, especially at the point of use.", "Should improper remixing of the composition occur, it might not release drug in a desired manner.", "Additionally, the compositions might be difficult to administer.", "Accordingly, compositions that have high miscibility or solubility of the polymer in the composition with the HVLCM are desirable.", "The lactic-acid based polymer may be linear or branched.", "The lactic acid-based polymer may be unsaturated or saturated.", "The lactic-acid based polymer may comprise a homopolymer, i.e., poly(lactic acid), which includes polylactide for purposes of the present disclosure.", "Alternatively, the lactic acid-based polymer may comprise a copolymer.", "In addition to lactic acid, the polymer may also comprise repeat units of other suitable materials, including but not limited to glycolic acid repeat units, glycolide repeat units, polyethylene glycol repeat units, caprolactone repeat units, valerolactone repeat units, and the like.", "For instance, the lactic acid-based polymer may comprise poly(lactic acid)(glycolic acid), which includes poly(lactide)(glycolide) for purposes of the present disclosure.", "The poly(lactic acid)(glycolic acid) typically has a lactic acid to glycolic acid molar ratio ranging from 100:0 to 40:60, such as from 95:5 to 60:40, 65:35 to 90:10, or 75:25 to 85:15.In some cases, the poly(lactic acid)(glycolic acid) has a lactic acid to glycolic acid molar ratio greater than 65:35, such as greater than 70:30, or greater than 75:25.Polymers with higher L:G ratio tend to be more compatible with sucrose acetate isobutyrate and tend to provide longer release profiles.", "The lactic acid-based polymer typically has a weight average molecular weight ranging from 1000 Daltons to 30,000 Daltons, such as from 4000 Daltons to 15,000 Daltons, further such as from 7000 Daltons to 30,000 Daltons, even further such as 7000 Daltons to 15,000 Daltons, and as an even further example, from 5000 Daltons to 10,000 Daltons.", "The weight average molecular weight may be less than or equal to about 15,000 Daltons, such as less than or equal to about 12,500 Daltons, or less than or equal to about 10,000 Daltons.", "Polymers with lower molecular weight tend to be more miscible with sucrose acetate isobutyrate and tend to provide shorter release profiles.", "The lactic acid-based polymer may have an alkoxy end group.", "For instance, the lactic acid-based polymer may comprise an alkoxy end group that consists of 8 to 24 carbons, such as 12 carbons.", "Initiators for the polymers include but are not limited to diol initiators including 1,6-hexanediol, 1,2-propanediol, 1,3-propanediol, 1,4-butanediol and the like; diol initiators including difunctional polyethylene glycol)s (PEGs); monofunctional alcohol initiators including 1-dodecanol, methyl lactate, ethyl lactate and the like; monofunctional PEGs including methoxy(polyethylene glycol) (mPEG); and other initiators including water, glycolic acid, lactic acid, citric acid, and the like.", "In some cases, the lactic acid-based polymer is initiated with a member selected from fatty alcohol and dial.", "For instance, the lactic-acid based polymer may be initiated with 1,6-hexanediol or with dodecanol.", "Compositions including polymers initiated dodecanol tend to provide a larger region of solubility than compositions including the polymer initiated with 1-hexanediol.", "As a result, compositions including polymer initiated with dodecanol, which results in a polymer having an alkoxy end group (which consists of 12 carbons), can require less solvent and/or can tend to be more resistant to phase separation.", "Surprisingly, compositions comprising polymers comprising alkoxy end group and made from small drug particles, e.g., median particle size, as measured by laser diffraction, of 10 μm or less, can have lower drug burst in vivo relative to compositions using other polymers.", "For example, compositions comprising dodecanol-initiated PLGA and made from risperidone in the form of small particles were shown to have a lower drug burst than compositions based on hexanediol-initiated PLGA.", "The lactic acid-based polymer is typically present in an amount ranging from 1 wt % to 50 wt %, such as from 1 wt % to 45 wt %, from 5 wt % to 35 wt %, from 5 \\A % to 30 wt %, from 5 wt % to 25 wt %, from 10 wt % to 25 wt %, from 15 wt % to 45 wt %, or such as from 15 wt % to about 35 wt %, based on total weight of the composition.", "The compositions can include one or more organic solvents.", "Solvents used in the practice of the present disclosure are typically biocompatible, polar, non-polar, hydrophilic, water miscible, water soluble, and/or non-toxic.", "In some embodiments, the pharmaceutical active agent is soluble in the solvent.", "The solvents used to inject the disclosed compositions into animals should not cause significant tissue irritation or necrosis at the site of implantation, unless irritation or necrosis is the desired effect.", "The solvent is typically water miscible and/or water soluble, so that it will diffuse into bodily fluids or other aqueous environment, causing the composition to assume a more viscous form.", "Certain solvents that are not water miscible and/or not water soluble may also be used in the practice of the disclosure.", "The one or more solvents should be biocompatible, which may eliminate some solvents from use in the disclosed compositions.", "In an embodiment, the one or more solvents should be good solvents for both the polymer and HVLCM.", "The solvent may comprise at least one member selected from N-methyl-pyrrolidone (NMP), dimethylsulfoxide (DMSO), propylene carbonate (PC), benzyl alcohol (BA), benzyl benzoate (BB), dimethylacetamide, caprylic/capric triglyceride, polyoxyethylene ester of 12-hydroxystearic acid, ethanol, ethyl lactate, glycofurol, propylene glycol, acetone, methyl acetate, ethyl acetate, methyl ethyl ketone, triacetin, dimethylformamide, tetrahydrofuran, caprolactam, decylmethylsulfoxide, oleic acid, tocopherol, linoleic acid, oleic acid, ricinoleic acid, pyrrolidone, diethyl phthalate, isopropylidene glycerol, and 1-dodecylazacycloheptan-2-one.", "In some cases, the solvent comprises at least one member selected from N-methyl-pyrrolidone (NMP), dimethylsulfoxide (DMSO), propylene carbonate (PC), benzyl benzoate (BB), dimethylacetamide, caprylic/capric triglyceride, polyoxyethylene ester of 12-hydroxystearic acid, ethanol, ethyl lactate, glycofurol, propylene glycol, acetone, methyl acetate, ethyl acetate, methyl ethyl ketone, triacetin, dimethylformamide, tetrahydrofuran, caprolactam, decylmethylsulfoxide, oleic acid, tocopherol, linoleic acid, oleic acid, ricinoleic acid, pyrrolidone, diethyl phthalate, isopropylidene glycerol, and 1-dodecylazacycloheptan-2-one.", "In some cases, the solvent comprises N-methyl-pyrrolidone.", "In other cases, the solvent comprises DMSO.", "In still other cases, the solvent comprises propylene carbonate.", "Propylene carbonate improves the settling and allows longer shelf life and storage at refrigerated conditions of 2-8° C. When SAIB is used as the HVLCM, the typical solvents include ethanol, dimethylsulfoxide, ethyl lactate, ethyl acetate, benzyl alcohol, triacetin, N-methylpyrrolidone, propylene carbonate, and glycofurol.", "Particularly preferred solvents include ethanol, dimethylsulfoxide, ethyl lactate, ethyl acetate, triacetin, N-methylpyrrolidone, propylene carbonate, and glycofurol.", "SAIB is not miscible with glycerol, corn oil, peanut oil, 1,2-propanediol, polyethylene glycol (PEG200), super refined sesame oil, and super refined peanut oil.", "Accordingly, the latter group of solvents is not preferred for use with SAIB.", "In certain cases, the solvent is not an alcohol.", "For instance, in some cases, the solvent is not ethanol.", "In other cases, the solvent is not benzyl alcohol.", "Thus, the composition may be free of alcohol, ethanol, and/or benzyl alcohol.", "The solvent typically has a solvent capacity of greater than or equal to 25%, such as greater than or equal to 20%, greater than or equal to about 15%, or greater than or equal to about 10%.", "The solvent is typically present in an amount ranging from 1 wt % to 60 wt %, such as from 1 wt % to 50 wt %, 1 wt % to 40 wt %, 5 wt % to 35 wt %, 5 wt % to 30 wt %, 10 wt % to 50 wt %, or 20 wt % to 40 wt %, based on total weight of the composition.", "Minimizing total solvent content of the compositions is generally biologically desirable.", "Increasing solvent content, however, can move a HVLCM/linear polymer/solvent composition from phase separation to single phase behavior.", "In some embodiments, a weight ratio of the HVLCM to the lactic acid-based polymer to the solvent ranges from 1:0.066-1.3:0.3-1.7, such as 1:0.25-0.5:0.4-0.8.In one embodiment of the disclosure, a composition comprises 5 wt % to 20 wt %, based on total weight of the composition, of particles comprising a pharmaceutical active agent that is risperidone or a pharmaceutically acceptable salt thereof, the particles having a median particle size, as measured by laser diffraction, ranging from 0.5 micrometer to 7 micrometers; and the composition further comprises from 30 wt % to 60 wt %, based on total weight of the composition, of sucrose acetate isobutyrate; from 5 wt % to 30 wt %, based on total weight of the composition, of a lactic acid based-polymer that is poly(lactic acid)(glycolic acid) comprising an alkoxy end group, the poly(lactic acid)(glycolic acid) having a lactic acid to glycolic acid molar ratio ranging from 95:5 to 60:40, the poly(lactic acid)(glycolic acid) having a weight average molecular weight ranging from 4000 Daltons to 15,000 Daltons; and 10 wt % to 40 wt %, based on total weight of the composition, of a solvent that is at least one member selected from N-methyl-pyrrolidone, propylene carbonate, and di methylsulfoxide.", "A variety of additives can optionally be included in the compositions to modify the properties of the compositions as desired.", "The additives can be present in any amount that is sufficient to impart the desired properties to the compositions.", "The amount of additive used will in general be a function of the nature of the additive and the effect to be achieved, and can be easily determined by one of skill in the art.", "When present, additive(s) are typically present in the compositions in an amount in the range from about 0.1 percent to about 20 percent by weight, relative to the total weight of the composition, and more typically, is present in the composition in an amount in the range from about 1, 2, or 5 percent to about 10 percent by weight, relative to the total weight of the composition.", "Certain additives, such as buffers, may be present only in small amounts in the relative to the total weight of the composition.", "Another additive for use with the present compositions are non-biodegradable polymers.", "Non-limiting examples of non-erodible polymers which can be used as additives include: polyacrylates, ethylene-vinyl acetate polymers, cellulose and cellulose derivatives, acyl substituted cellulose acetates and derivatives thereof, non-erodible polyurethanes, polystyrenes, polyvinyl chloride, polyvinyl fluoride, poly(vinyl imidazole), chlorosulphonated polyolefins, and polyethylene oxide.", "Exemplary non-biodegradable polymers include polyethylene, polyvinyl pyrrolidone, ethylene vinylacetate, polyethylene glycol, cellulose acetate butyrate (“CAB”) and cellulose acetate propionate (“CAP”).", "A further class of additives which can be used in the disclosed compositions are natural and synthetic oils and fats.", "Oils derived from animals or from plant seeds of nuts typically include glycerides of the fatty acids, chiefly oleic, palmitic, stearic, and linolenic.", "As a rule the more hydrogen the molecule contains, the thicker the oil becomes.", "Non-limiting examples of suitable natural and synthetic oils include vegetable oil, peanut oil, medium chain triglycerides, soybean oil, almond oil, olive oil, sesame oil, peanut oil, fennel oil, camellia oil, corn oil, castor oil, cotton seed oil, and soybean oil, either crude or refined, and medium chain fatty acid triglycerides.", "Fats are typically glyceryl esters of higher fatty acids such as stearic and palmitic.", "Such esters and their mixtures are solids at room temperatures and exhibit crystalline structure.", "Lard and tallow are examples.", "In general oils and fats increase the hydrophobicity of the composition, slowing degradation and water uptake.", "Another class of additives which can be used in the disclosed compositions comprise carbohydrates and carbohydrate derivatives.", "Non-limiting examples of these compounds include monosaccarides (simple sugars such as fructose and its isomer glucose (dextrose); disaccharides such as sucrose, maltose, cellobiose, and lactose; and polysaccarides.", "Other additives, such as preservatives, stabilizers, anti-oxidants, coloring agents, isotonic agents, humectants, sequesterants, vitamins and vitamin precursors, surfactants and the like, may be added as needed.", "Examples of preservatives include paraben derivatives, such as methyl paraben and propyl paraben.", "Examples of anti-oxidants include butyl hydroxyanisole, butyl hydroxytoluene, propyl gallate, vitamin E acetate, and purified hydroquinone.", "Humectants include sorbitol.", "Sequesterants include citric acid.", "In some aspects, the composition may further comprise at least one member selected from viscosity enhancers, antioxidants, preservatives, and particle stabilizers.", "For instance, the composition may comprise at least one member selected from ricinoleic acid, polyoxyethylene-polyoxypropylene block copolymer, polyvinylpyrrolidone, polyethyeleneglycol (e.g., PEG4000), and Cremophor EL® ethoxylated castor oil which includes polyethylene glycol ether.", "As noted above, an aspect of the compositions according to the present disclosure is the miscibility or solubility of the polymer in the composition with the HVLCM.", "In situations where the polymer is not miscible or soluble in the composition with the HVLCM, phase separation of the polymer and the HVLCM in the composition may occur.", "Once this occurs, it may be very difficult to remix the polymer and the HVLCM, especially at the point of use.", "Should improper or no remixing occur, undesirably wide variations in release performance might result.", "Accordingly, compositions that have high miscibility or solubility of the polymer in the composition with the HVLCM are desirable.", "The present compositions typically possess high miscibility or solubility of the polymer in the composition with the HVLCM.", "In one aspect of the disclosure, the composition may comprise the HVLCM, the polymer, one or more good solvents for the polymer, and one or more good solvents for the HVLCM, with the resultant composition being a single phase.", "Solubility and phase separation of various HVLVM/linear polymer/solvent composition may be investigated by visual techniques well known to those skilled in the art.", "For compositions with significant instability or tendency to phase-separate, the linear polymer may absorb solvent but remain as a separated, very viscous layer or phase in the composition.", "Other compositions might be rendered into a uniform clear solution by sufficient heating and mixing.", "However, when cooled to room temperature, two clear liquid phases may form.", "Sometimes, the two clear layers may not be easy to detect, thus requiring strong light and a thorough inspection of the composition to discern the boundary between the two phases.", "In a number of cases, compositions may appear clear and uniform on initial cooling to room temperature, but when left quiescent at room temperature for a period of several days or greater, the compositions may separate into two phases.", "For compositions that are at the border of phase separation, the composition may turn cloudy and sometimes slowly separate into two phases.", "The HVLCM, the lactic acid-based polymer, and the solvent are typically monophasic when stored at 25° C. for a period of time, such as 7 days, for 1 month, for 24 months, or longer.", "In one embodiment, the composition is monophasic and comprises: from 25 wt % to 80 wt %, based on total weight of the composition, of sucrose acetate isobutyrate; a poly(lactic acid)(glycolic acid) comprising an alkoxy end group wherein the alkoxy end group consists of 12 carbons, the poly(lactic acid)(glycolic acid) having a lactic acid to glycolic acid molar ratio of at least 70:30; and an organic solvent that maintains the composition monophasic at 25° C. and 1 atmosphere.", "In another aspect of the disclosure, a method of reducing phase separation comprises combining: a pharmaceutical active agent, a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere; a lactic acid-based polymer; and an organic solvent.", "In another aspect of the disclosure, a method of reducing phase separation, comprises combining: a pharmaceutical active agent with a means for achieving the reduction of phase separation.", "The composition typically has a viscosity of less than 5000 cP, such as less than 3000 cP.", "For instance, the viscosity may range from 50 cP to 2000 cP, such as 500 cP to 1500 cP.", "In one aspect, the composition comprises a pharmaceutical active agent that is risperidone or a pharmaceutically acceptable salt thereof; and means for extending a release profile of the pharmaceutical active agent when the composition is administered to a patient in need thereof.", "In another aspect of the disclosure, the composition comprises a pharmaceutical active agent that is risperidone or a pharmaceutically acceptable salt thereof; and a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere, a lactic acid-based polymer comprising an alkoxy end group, and an organic solvent in a ratio sufficient to maintain a therapeutically effective plasma concentration of the risperidone or pharmaceutically acceptable salt thereof for a period of at least 7 days when the composition is administered parenterally to a patient.", "The period may be at least 14 days, such as at least 21 days, at least 28 days, or at least 84 days.", "In another aspect, the composition comprises risperidone or pharmaceutically acceptable salt thereof; and a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere, a lactic acid-based polymer comprising an alkoxy end group, and an organic solvent in a ratio such that when the composition is administered parenterally, an amount of pharmaceutical active agent released from the composition provides an AUC(0 to 1 day) that is less than 20%, such as less than 15%, less than 10%, or less than 5%, of AUC(0 to 28 days).", "In yet another aspect, the composition comprises a pharmaceutical active agent, wherein when the composition is administered parenterally, an amount of pharmaceutical active agent released from the composition at 4 weeks of administration to a patient ranges from 20% to 100%, such as 20% to 75%, 30% to 60%, or 40% to 50%, of a total amount of the pharmaceutical active agent in the composition.", "In one aspect of the disclosure, the composition comprises a pharmaceutical active agent, wherein when the composition is placed in phosphate buffered saline at 37° C., an amount of pharmaceutical active agent released from the composition at 4 weeks of placement in the phosphate buffered saline ranges from 20% to 100%, such as 30% to 90%, 40% to 80%, or 50% to 70%, of a total amount of the pharmaceutical active agent in the composition.", "In yet another aspect of the disclosure, the composition comprises a pharmaceutical active agent, wherein when the composition is placed in phosphate buffered saline at 37° C., an amount of pharmaceutical active agent released from the composition at 24 hours after placement in the phosphate buffered saline is less than 20%, such as less than 15%, less than 10%, or less than 5%, of an amount released at 28 days.", "Further, the amount of pharmaceutical active agent released at 28 days after placement in the phosphate buffered saline at 37° C. may be greater than 50%, such as greater than 60%, or greater than 70%, of a total amount of pharmaceutical active agent in the composition.", "In another aspect of the disclosure, the composition comprises a pharmaceutical active agent, wherein when the composition is administered parenterally, an amount of pharmaceutical active agent released from the composition provides an AUC(0 to 1 day) that is less than 20%, such as less than 15%, less than 10%, or less than 5%, of AUC(0 to 28 days).", "In still another aspect, the composition comprises a pharmaceutical active agent, wherein when the composition is administered parenterally, an amount of pharmaceutical active agent released from the composition provides an AUC(0 to 1 day) that is less than 20%, such as less than 10%, or less than 5%, of AUCinf.", "In one embodiment of the disclosure, a method of improving reproducibility of a release profile, comprises combining: a pharmaceutical active agent, a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere; a lactic acid-based polymer; and an organic solvent.", "In one aspect, the composition comprises a pharmaceutical active agent that is risperidone or a pharmaceutically acceptable salt thereof; and means for reducing settling of the pharmaceutical active agent within the composition.", "In another aspect, the composition comprises a pharmaceutical active agent, wherein when 2 mL of the composition is placed in an upright 2 mL vial for 10 months at 5° C., a difference between top concentration and bottom concentration divided by initial concentration is less than 35%, such as less than 15% or less than 10%.", "The top concentration is concentration of pharmaceutical active agent of the top 10% of the composition within the upright 2 mL vial after the 10 months storage.", "The bottom concentration is concentration of pharmaceutical active agent of the bottom 10% of the composition within the upright 2 mL vial after the 10 months storage.", "The initial concentration is concentration of pharmaceutical active agent of the composition before the 10 months storage.", "In one aspect, the composition is a unit dosage form comprising from 0.01 mg to 500 mg, such as 1 mg to 250 mg or 10 mg to 100 mg of the pharmaceutical active agent.", "The composition may be contained within a vial, a syringe, a pre-filled syringe, an autoinjector, a needle-free injector.", "The composition may be contained within a receptacle.", "The compositions of the present disclosure may be made by any of the various methods and techniques known and available to those skilled in the art in view of the directions supplied in this specification.", "For instance, polymer (DD, PLGA) may be dissolved in propylene carbonate.", "SAIB may be added to the mixture and allowed to dissolve and mix to make the vehicle (SAIB/PC/PLGA).", "Risperidone powder (e.g., produced by agitator bead milling and lyophilization) may then be added to the vehicle, and the suspension may be mixed using a homogenizer (or other suitable mixer).", "In certain embodiments, first combine room temperature solvent(s), room temperature polymer and HVLCM heated to 80° C. Next, mix at 60-80° C. for a period of several hours to overnight (8-16 hours) until the composition is well-mixed.", "In other embodiments, dissolve the linear polymer in all of the solvent(s).", "Add hot HVLCM (heated at up to 80° C.).", "Then, mix at temperature of room temperature to 80° C. for 1 hour to overnight (8-16 hours) until the composition is well-mixed.", "In yet other embodiments, dissolve the linear polymer in some of the solvent(s).", "Mix the remainder of the solvent(s) with the HVLCM.", "Add hot HVLCM/solvent mixture (heated at up to 80° C.) to the linear polymer/solvent(s) mixture.", "Then, mix at temperatures that may range from room temperature to 80° C. for 1 hour to overnight (8-16 hours), until the composition is well-mixed.", "The compositions are typically prepared at temperatures above room temperature.", "Once mixed, the compositions may be cooled back to room temperature and initially observed for cloudiness (indication of incipient phase separation), the presence of two liquid layers (usually of low to moderate viscosity) or the presence of a viscous layer underneath a less viscous layer.", "The compositions may then be left at room temperature for a significant period (usually one week or greater) and observed again for cloudiness, separation into two layers of moderate viscosity or the presence of a viscous layer.", "A surprising result of the present disclosure is the ability to obtain small particles comprising pharmaceutical active agent, e.g., risperidone, via wet milling.", "In one aspect, a process comprises wet milling a pharmaceutical active agent in an aqueous solution at less than 20° C. to form a milled pharmaceutical active agent; maintaining the milled pharmaceutical active agent at less than 5° C.; and lyophilizing the milled pharmaceutical active agent to form a lyophilized pharmaceutical active agent having a median particle size, as measured by laser diffraction, of less than 10 micrometers, such as less than 5 micrometers, less than 3 micrometers, or less than 2 micrometers.", "In another aspect, a suspension is produced by wet milling a pharmaceutical active agent in an aqueous solution at less than 20° C. to form a milled pharmaceutical active agent; maintaining the milled pharmaceutical active agent at less than 5° C.; and lyophilizing the milled pharmaceutical active agent to form a lyophilized pharmaceutical active agent having a median particle size, as measured by laser diffraction, of less than 10 micrometers, such as less than 5 micrometers, less than 3 micrometers, or less than 2 micrometers.", "The composition may be gamma-irradiated to sterilize the composition.", "After storage for 150 days at 37° C., the weight average molecular weight of the lactic acid-based polymer of the gamma-irradiated composition is at least 90%, such as at least 95%, of the weight average molecular weight of the lactic acid-based polymer of an otherwise identical composition that is not gamma-irradiated before being stored for 150 days at 37° C. The weight average molecular weight of the lactic acid-based polymer of the composition after storage for 150 days at 37° C. is typically at least 50%, such as at least 60%, of the weight average molecular weight of the lactic acid-based polymer immediately before gamma radiation.", "Thus, in one aspect of the present disclosure a process of sterilizing a composition is provided, which process comprises gamma-irradiating a composition as defined elsewhere herein.", "In some cases, the composition is stored at room temperature (e.g., 25° C.).", "In other cases, the composition is stored at 5° C. In still other cases, the composition is stored at −20° C. Propylene carbonate improves the settling performance of compositions and allows longer shelf life and storage at refrigerated conditions of 2-8° C. when compared with compositions incorporating only NMP as the solvent.", "The results achieved with propylene carbonate are unexpected as the improvement is greater than would have been predicted from density considerations, as discussed in more detail below.", "Propylene carbonate suspensions typically exhibit improved, acceptable settling performance, partially because PC has higher density than NMP.", "The higher density vehicle is closer to the density of risperidone; therefore the property helps to prevent the drug from settling.", "Another reason is that risperidone has higher solubility in NMP than in PC.", "Recrystallization and crystal growth may occur faster in NMP containing compositions which results in increasing particle size and settling rate with time.", "Settling at low concentration of a spherical particle in a Newtonian fluid is described by the Stokes settling equation: v = 2  r 2  ( ρ 1 - ρ 2 )  g 9  η where: v=settling velocity r=particle radius ρ 1 and ρ 2 =density of particle and fluid, respectively g=acceleration due to gravity η=viscosity of fluid For samples in a centrifuge, the acceleration due to gravity is replaced by the centripetal acceleration in the centrifuge: v = 2  r 2  ( ρ 1 - ρ 2 )  ω 2  R 9  η where: ω=angular velocity R=centrifuge radius The conditions for these equations are not strictly obeyed in the experiments described in this disclosure, but the equations can serve as a guide to expected behavior: Larger particles (larger r) are expected to settle more quickly.", "The larger the density difference between the particle and the fluid, the larger the expected settling velocity.", "Differences in settling velocity are expected to be proportional to overall differences in density.", "The lower the viscosity of the fluid, the more quickly the particles are expected to settle.", "The magnitude of the improvement in settling performance of propylene carbonate compositions was unexpectedly greater than would have been expected from theory.", "While not being bound by hypotheses, this unexpected result may reflect a slower rate of particle size growth during storage for the PC compositions.", "This does not appear to be due to the actual solubility of risperidone in the placebo vehicles, but might reflect the risperidone solubility in the respective solvents.", "The disclosed compositions may be administered to subjects using conventional routes of administration, such as injection.", "Effective amounts of biologically active substances may be incorporated into the disclosed compositions so as to achieve a desired pharmacological effect.", "In one aspect of the disclosure, a method of administering a pharmaceutical active agent such as, but not limited to, risperidone, paliperidone, or a combination thereof, comprises administering an effective amount of the composition.", "The composition typically comprises from 0.1 mg to 500 mg, such as 1 mg to 250 mg, 5 mg to 150 mg, or 25 mg to 150 mg, of the pharmaceutical active agent, such as risperidone or a pharmaceutically acceptable salt thereof.", "The composition may be administered on a regular basis, e.g., twice weekly or once a month.", "The composition is typically administered in an amount ranging from 0.05 mL to 10 mL, such as 0.1 mL to 8 mL, or 1 mL to 5 mL.", "In one aspect, the pharmaceutical active agent and any metabolites thereof have a plasma level in the patient of at least 1 ng/mL, such as at least 5 ng/mL, or at least 8 ng/mL, at 28 days after administration.", "For instance, 9-OH risperidone is an active metabolite of risperidone.", "In another aspect, the median Cmax of the pharmaceutical active agent ranges from 5 ng/mL to 300 ng/mL, such as 5 to 100 ng/mL, 10 ng/mL to 70 ng/mL, or even 100 ng/mL to 200 ng/mL.", "The median Cmax to Cmin ratio of the pharmaceutical active agent, as measured over 28 days, 21 days, or 14 days after administration, typically ranges from 2 to 40, such as from 5 to 30, or 10 to 20.An amount of pharmaceutical active agent delivered into plasma at 24 hours of subcutaneous administration typically ranges from 0.5% to 50%, such as 0.5% to 20%, 0.5% to 15%, 1% to 10%, 2% to 5%, or even 20% to 50%, of a total amount of the pharmaceutical active agent administered.", "An amount of pharmaceutical active agent delivered into plasma at 4 weeks of subcutaneous administration ranges from 20% to 100%, such as 20% to 75%, or 30% to 60%, of a total amount of the pharmaceutical active agent administered.", "An amount of pharmaceutical active agent delivered into plasma at 24 hours of subcutaneous administration divided by an amount of pharmaceutical active agent delivered at 4 weeks of administration ranges from 0.05 to 0.2, such as 0.05 to 0.15, or 0.08 to 0.12.The administering may be subcutaneous, intramuscular, parenteral, via a catheter, etc.", "The administration may be accomplished via a needle and syringe, pump, patch-pump, bolus injector, infusion, etc.", "In one aspect of the disclosure, a method of treating at least one of schizophrenia and bipolar disorder comprises administering an effective amount of a composition that contains a pharmaceutical active agent that is an anti-schizophrenia agent to a patient in need thereof.", "For instance, the anti-schizophrenia agent may comprise at least one of risperidone and paliperidone, or a pharmaceutically acceptable salt thereof.", "In one embodiment, the composition is contained in a needle-free injector.", "In one embodiment, the needle-free injector is Zogenix's DosePro® Needle-free injector.", "FIG.", "1 presents a longitudinal section through the DosePro® needle-free injector internal drug storage and delivery componentry.", "In FIG.", "1 , the injection force is provided by a compressed gas spring, which comprises a cylinder 1 enclosed at one end, and containing a gas, typically nitrogen, typically at a pressure between 150 and 300 bar.", "Contained within the cylinder is a ram 2 .", "The end of the ram has a frusto-conical, truncated cone—portion 3 and a flange 4 .", "There is a double o-ring seal 5 situated between the truncated cone section 3 and the flange 4 .", "Prior to triggering the device, the ram 2 is held in the position illustrated in FIG.", "1 by a latch 6 which sits in a groove in the dispensing member.", "The upper surface of the groove forms a cam surface 7 .", "Consequently, there is force urging the latch to move to the left.", "In the configuration shown in FIG.", "1 , the latch is restricted from moving by the outer ring 8 .", "At the lower end of the cylinder 1 , there is an outwardly directed flange 9 .", "The cylinder is held in place by crimping the flange 9 to another outwardly directed flange 10 on the upper end on a coupling 11 .", "The sleeve 8 consists of an upper sleeve portion 12 within which the cylinder is situated, and a lower sleeve portion 13 .", "The lower sleeve portion 13 is connected to the coupling 11 by inter-engaging screw threads 14 formed on the inner and outer walls of the lower sleeve portion 13 and the coupling respectively 11 .", "The injector has a cartridge 15 which contains the medicament.", "In the cartridge there is a piston 16 , slidingly and sealingly located therein.", "The piston 16 may comprise a cylindrical portion containing two larger diameter ribs, and a frusto-conical portion.", "The piston 16 is in contact with the medicament 17 and at the other end of the cartridge 15 there is a discharge orifice 18 .", "Adjacent to the orifice 18 there is an interface seal 19 contained within a seal carrier 20 .", "The interface seal 19 is required for filling the needle-free device as described in PCT/GB9700889.A stopper 20 a seals the medicament into the capsule.", "Seal 19 , seal carrier 20 , and stopper 20 a , comprise the cap that must be removed prior to delivery.", "To place the device in the ready to deliver state, the cap must be snapped off at the frangible joint 21 .", "This removes the seal 19 and exposes the orifice 18 .", "The trigger blocking mechanism 22 , which prevents the medication cartridge from moving back toward the upper sleeve portion 22 , thereby preventing delivery, is removed.", "Finally, latch 6 must be moved from the first (safe) position, to the second (ready to deliver) position.", "The latch 6 is incorporated into a groove in the dispensing member 2 —not only does the groove have a cam surface 7 but also a locking surface 27 which is perpendicular to the dispensing member axis and is located radially inward of the cam surface 7 .", "Additionally, to access the latch 6 there is an opening 28 in the upper sleeve 12 , which prior to triggering is aligned with the latch 6 .", "FIGS.", "2 a, b and c illustrate the operation of the safety mechanism.", "When the latch and dispensing member are initially assembled, the latch occupies the first (safe) position, as shown in FIG.", "2 a .", "In this position, the dispensing member-engaging latch portion 29 is acted on by the locking surface 27 .", "Frictional force ensures that the latch is held rigid by the locking surface—typically the dispensing member exerts a force of at least 100N.", "The latch is placed in the second (ready to deliver) position using a pin which fits through opening 28 to push the latch in the direction of the arrow P into the position shown in FIG.", "2 b , (and in FIG.", "1 ).", "In this position the dispensing member engaging latch portion 29 is in contact with the radially inner end of the cam surface 7 .", "To cause delivery, the orifice 18 is then placed against the skin of the patient.", "Practically, this involves holding the device by the upper sleeve 12 portion.", "The upper sleeve 12 is then moved downwards with respect to the lower sleeve 13 , bringing aperture 25 in the wall of the upper sleeve portion 8 into alignment with the latch 6 .", "The latch then moves to the left into the aperture 25 , under the force exerted on it by the cam surface 7 formed in the dispensing member 3 into the position shown in FIG.", "2 c .", "The injector then delivers.", "It is advantageous to have a mechanism that places the device in the ready to deliver state in a simple motion or motions.", "FIG.", "3 illustrates one embodiment of the combined needle-free injector plus means for disengaging the safety mechanism 30 .", "In this Figure, the means for disengaging the safety mechanism consists of a cap 31 enclosing, and holding rigidly, the seal carrier 20 , a lever 32 and a collar 33 .", "The lever contains a lip 34 at the far end, over which the cap 31 is positioned.", "This ensures that the lever 32 cannot be moved before the outer cap 31 is removed, which in turn ensures that the user cannot move the latch or disengage the safety mechanism until the cap has been removed.", "The lever 32 is pivoted around the pivot axis 35 , with the pivoted surface in contact with injector being a cam surface 36 .", "The force required to pivot lever 32 is in the range from about 2N to about 30N.", "The collar 33 contains a pin 37 which extends into the device through the opening 28 in the upper sleeve 12 to impinge on the far side of the latch 6 .", "The force required to move the latch is in the range from about 20N to about 120N.", "To stop the upper sleeve section 12 moving with respect to the lower sleeve section 13 , there are block sections 38 between the upper and lower sleeves, which form part of the collar 33 .", "To deliver the device contents, the cap 31 is removed, exposing the injection orifice 18 .", "With the outer cap 31 removed, the lip 34 is exposed, enabling the lever 32 to rotate about the pivot axis 35 .", "Only when the outer cap 31 is removed can the lever 32 be rotated.", "As the lever 32 rotates, the cam surface 36 forces the collar 33 to move in the direction Q in FIG.", "3 , pushing the pin 37 against the latch 6 .", "When the lever 32 has rotated through a complete cycle, approximately 180 degrees, the latch 6 moves to the second position, as shown in FIG.", "2 b .", "The blocks 38 no longer restrict the movement of the upper sleeve 12 with respect to the lower sleeve 13 and the device can trigger as described above.", "By integrating the cap 31 to the lever 32 with a flexible joint at the tip 34 , the mechanism can also be configured to ensure that the user removes the stopper and sets the safety in a single action.", "In one aspect, a needle-free injector comprises a composition comprising a pharmaceutical active agent.", "The needle-free injector may further comprise a drug capsule.", "The drug capsule may be transparent or partly transparent.", "The drug capsule may be closed at one end by a piston.", "The piston may comprise a polymer, such as a clear polymer and such as polytetrafluoroethylene.", "Alternatively, the drug capsule may comprise glass, such as borosilicate glass.", "The glass may have undergone ion exchange strengthening.", "In some cases, the transparent portion of the drug capsule does not change color when gamma-irradiated.", "In some cases, the drug capsule is prefilled.", "The needle-free injector may be single use and disposable.", "The drug capsule may comprise at least one injection orifice.", "The at least one injection orifice may be closed during storage by a sealing element.", "The sealing element may be held rigidly to the injection orifice by a seal carrier.", "In some cases, the seal carrier must be removed prior to use.", "The seal carrier may be connected to the drug capsule by at least one element selected from: a frangible connection, a screw connection, a bayonet connection, and a luer connection.", "The needle-free injector may comprise a triggering mechanism.", "The triggering mechanism may be activated by pressing the at least one injection orifice against the target injection surface.", "The needle-free injector may further comprise a safety mechanism that ensures that the device cannot be actuated prematurely.", "The safety mechanism ensures that the device cannot be actuated until after removal of the seal carrier.", "The needle-free injector may comprise a self-contained energy source.", "The energy source comprises at least one member selected from: a compressed mechanical spring, a compressed gas, a pyrotechnic charge, and a battery.", "The needle-free injector may further comprise a ram which upon activation of the triggering mechanism, under the urging of the energy source traverses a gap and subsequently strikes the piston, creating a pressure spike in the composition.", "The urging of the energy source, the mass of the ram, the length of the gap, the mechanical properties of the piston, and the size of the orifice may be selected such that in use, more than 90% of injections inject more than 90% of the composition subcutaneously.", "In one exemplary embodiment, the composition is delivered using a needle-free injector.", "Needle-free injectors are representative examples for the delivery of antipsychotic active pharmaceutical ingredients for a number of reasons.", "Psychotic patients may present for treatment in a highly agitated state, and the sight of a needle, or the puncture of the skin by a needle, may significantly increase this agitation.", "The psychotic state and agitation may increase the likelihood of the patient moving erratically during administration of the composition, increasing the risk of injury to the patient, and also increasing the risk of injury and exposure of the care giver to pathogens.", "Needle-free injectors remove the requirements of sharps disposal, further simplifying administration procedures and making them safer.", "In one aspect, the present disclosure comprises a unit dosage form that may be prefilled, sterile, compatible with gamma sterilization, single use disposable, an auto-injector, may include a safety mechanism to prevent premature actuation, may include additional safety features to prevent or reduce the incidence to needle stick injury, including but not limited to needle shields, needle retraction and needle-free injection, may be portable and include a self contained power source, and may be disabled after use.", "An exemplary embodiment of the needle-free injector is prefilled, and portable with a self contained energy source.", "This embodiment further simplifies the administration, and allows a skilled care giver to give more attention to the patient and spend less time preparing the injection.", "This embodiment, and the removal of the requirement for sharps disposal, may also enable administration in a home or residential or long term care facility setting by a skilled care giver, family member, or the self administration by the patient.", "For example, the preparation of and delivery from a needle-free injector would require less than 10 steps, such as less than 5 steps, and further such as 3 steps or fewer.", "For example, one embodiment requires only three steps: The removal of an orifice cap, actuation of a safety mechanism actuator to place the device in the ready to deliver state, and pressing the orifice against the desired injection site to trigger.", "It may also be possible to combine the actions of removal of an orifice cap and actuation of the safety mechanism, further simplifying delivery.", "Needle-free injectors can be used, for example, for the delivery of elevated viscosity compositions, including those of the current disclosure.", "Delivery of high viscosity compositions by needle and syringe can be difficult due to high required hand strength and long delivery times.", "These problems often lead to the requirement for delivery via infusion or bolus injectors.", "The long delivery times via needle and syringe or infusion can be especially problematic for the treatment of psychotic patients, who may present in an agitated state.", "Needle-free injection can significantly reduce delivery time, as the ratio of delivery orifice length to lumen diameter, which is very small compared to needle systems such as syringes or infusion systems, generally reduces or avoids the development of viscous flow during delivery, allowing the delivery of viscous compositions in short times.", "This feature in combination with a self contained energy source removes the requirement of high hand strength.", "The advantages of needle-free injection for high viscosity compositions are described in U.S. Pat.", "No.", "8,066,661.The combination of a sufficiently powerful source of energy and low viscous losses in a needle-free injector leads to very short delivery times, in general less than 0.5 seconds, such as less than 0.2 seconds, and further such as about 0.1 seconds or less.", "These short delivery times are less than human reaction times, and significantly reduce the possibility of the patient moving during administration, further improving safety to the patient and caregiver.", "Compliance with prescribed treatment is an issue with all treatment regimens, and can be particularly problematic in the treatment of psychotic patients.", "Combinations of features of a delivery system, and particularly needle-free injectors such as prefilled, single use, disposable, requiring a minimized number of steps for preparation and delivery, portability, a self contained power source, no requirement for sharps disposal, removal of risk of needle stick injury, short delivery times, low hand strength requirements, ability for administration in a home or care facility, ability for self administration, avoidance of premature actuation, and removal of fear and agitation caused by needles.", "Those features, alone or in combination, can work to increase compliance.", "Needle-free injectors are available using many different types of energy, and the energy may be supplied by the user, for example where a spring is manually compressed and latched to temporarily store the energy until it is required to “fire” the injector.", "Alternatively, the injector may be supplied having the energy already stored—for instance by means of a precompressed spring (mechanical or gas), or pyrotechnic charge.", "Some injectors are intended for disposal after a single use, whereas others have a re-loadable energy storage means and a disposable medicament cartridge, and there are many combinations to suit particular applications and markets.", "For the purposes of the present disclosure, the term “actuator” will be used to describe the energy storage and release mechanism, whether or not it is combined with the medicament cartridge.", "In all cases, it is necessary to arrange for sufficient force at the end of the piston stroke to deliver the entire medicament at the required pressure.", "EP 0 063 341 and EP 0 063 342 disclose a needle-free injector which includes a piston pump for expelling the liquid to be injected, which is driven by a motor by means of a pressure agent.", "The liquid container is mounted laterally to the piston pump.", "The amount of liquid required for an injection is sucked into the pump chamber by way of an inlet passage and a flap check valve when the piston is retracted.", "As soon as the piston is moved in the direction of the nozzle body the liquid is urged through the outlet passage to the nozzle and expelled.", "The piston of the piston pump is a solid round piston.", "EP 0 133 471 describes a needle-free vaccination unit which is operated with carbon dioxide under pressure, from a siphon cartridge by way of a special valve.", "EP 0 347 190 discloses a vacuum compressed gas injector in which the depth of penetration of the injected drug can be adjusted by means of the gas pressure and the volume of the drug can be adjusted by way of the piston stroke.", "EP 0 427 457 discloses a needle-free hypodermic syringe which is operated by means of compressed gas by way of a two-stage valve.", "The injection agent is disposed in an ampoule which is fitted into a protective casing secured to the injector housing.", "The ampoule is fitted on—to the end of the piston rod.", "Disposed at the other end of the ampoule is the nozzle whose diameter decreases towards the end of the ampoule.", "WO 89/08469 discloses a needle-free injector for one-off use.", "WO 92/08508 sets forth a needle-free injector which is designed for three injections.", "The ampoule containing the drug is screwed into one end of the drive unit, with the piston rod being fitted into the open end of the ampoule.", "At its one end, the ampoule contains the nozzle through which the drug is expelled.", "A displaceable closure plug is provided approximately at the center of the length of the ampoule.", "The dose to be injected can be adjusted by changing the depth of the ampoule.", "The piston rod which projects from the drive unit after actuation of the injector is pushed back by hand.", "Both units are operated with compressed gas.", "WO 93/03779 discloses a needle-free injector with a two-part housing and a liquid container which is fitted laterally to the unit.", "The drive spring for the piston is stressed by means of a drive motor.", "The spring is released as soon as the two parts of the housing are displaced relative to each other by pressing the nozzle against the injection location.", "Respective valves are provided in the intake passage for the liquid and in the outlet of the metering chamber.", "WO 95/03844 discloses a further needle-free injector.", "It includes a liquid-filled cartridge which at one end includes a nozzle through which the liquid is expelled.", "At the other end the cartridge is closed by a cap-type piston which can be pushed into the cartridge.", "A piston which is loaded by a pre-stressed spring, after release of the spring, displaces the cap-type piston into the cartridge by a predetermined distance, with the amount of liquid to be injected being expelled in that case.", "The spring is triggered as soon as the nozzle is pressed sufficiently firmly against the injection location.", "This injector is intended for one-off or repeated use.", "The cartridge is arranged in front of the spring-loaded piston and is a fixed component of the injector.", "The position of the piston of the injector which is intended for a plurality of uses is displaced after each use by a distance in a direction towards the nozzle.", "The piston and the drive spring cannot be reset.", "The pre stressing of the spring is initially sufficiently great to expel the entire amount of liquid in the cartridge all at once.", "The spring can only be stressed again if the injector is dismantled and the drive portion of the injector assembled with a fresh, completely filled cartridge.", "U.S. Pat.", "No.", "5,891,086 describes a needle-free injector, combining an actuator and a medicament cartridge.", "The cartridge is pre-filled with a liquid to be injected in a subject, and having a liquid outlet and a free piston in contact with the liquid, the actuator comprising an impact member urged by a spring and temporarily restrained by a latch means, the impact member being movable in a first direction under the force of the spring to first strike the free piston and then to continue to move the piston in the first direction to expel a dose of liquid through the liquid outlet, the spring providing a built-in energy store and being adapted to move from a higher energy state to a lower energy state, but not vice versa.", "The actuator may comprise trigger means to operate the said latch, and thus initiate the injection, only when a predetermined contact force is achieved between the liquid outlet of the said cartridge and the subject.", "Further examples and improvements to this needle-free injector are found in U.S. Pat.", "No.", "6,620,135, U.S. Pat.", "No.", "6,554,818, U.S. Pat.", "No.", "6,415,631, U.S. Pat.", "No.", "6,409,032, U.S. Pat.", "No.", "6,280,410, U.S. Pat.", "No.", "6,258,059, U.S. Pat.", "No.", "6,251,091, U.S. Pat.", "No.", "6,216,493, U.S. Pat.", "No.", "6,179,583, U.S. Pat.", "No.", "6,174,304, U.S. Pat.", "No.", "6,149,625, U.S. Pat.", "No.", "6,135,979, U.S. Pat.", "No.", "5,957,886, U.S. Pat.", "No.", "5,891,086, and U.S. Pat.", "No.", "5,480,381.U.S.", "Pat.", "No.", "3,859,996, Mizzy, discloses a controlled leak method to ensure that the injector orifice is placed correctly at the required pressure on the subject's skin at the correct normal to the skin attitude.", "When placement conditions are met, controlled leak is sealed off by contact pressure on the subject's skin, the pressure within the injector control circuit rises until a pressure sensitive pilot valve opens to admit high pressure gas to drive the piston and inject the medicament.", "WO Patent 82/02835, Cohen and Ep-A-347190, Finger, discloses a method to improve the seal between the orifice and the skin and prevent relative movement between each.", "This method is to employ a vacuum device to suck the epidermis directly and firmly onto the discharge orifice.", "The discharge orifice is positioned normal to the skin surface in order to suck the epidermis into the orifice.", "This method for injection of the medicament into the skin and the injector mechanism are different and do not apply to the present disclosure because of its unique ampule design.", "U.S. Pat.", "No.", "3,859,996, Mizzy, discloses a pressure sensitive sleeve on the injector which is placed on the subject, whereby operation of the injector is prevented from operating until the correct contact pressure between orifice and the skin is achieved.", "The basic aim is to stretch the epidermis over the discharge orifice and apply the pressurized medicament at a rate which is higher than the epidermis will deform away from the orifice.", "U.S. Pat.", "No.", "5,480,381, T. Weston, discloses a means of pressuring the medicament at a sufficiently high rate to pierce the epidermis before it has time to deform away from the orifice.", "In addition, the device directly senses that the pressure of the discharge orifice on the subject's epidermis is at a predetermined value to permit operation of the injector.", "The device is based on a cam and cam follower mechanism for mechanical sequencing, and contains a chamber provided with a liquid outlet for expelling the liquid, and an impact member, to dispell the liquid.", "U.S. Pat.", "No.", "5,891,086, T. Weston, describes a needle-free injector embodiment that contains a chamber that is pre-filled with a pressurized gas which exerts a constant force on an impact member in order to strike components of a cartridge and expulse a dose of medicament.", "This device contains an adjustment knob which sets the dose and the impact gap, and uses direct contact pressure sensing to initiate the injection.", "In an exemplary embodiment of the disclosure for the delivery of sustained release risperidone and other active pharmaceutical ingredients, the composition may be delivered using a needle-free injector which is single use, disposable, portable, and has a self contained energy source comprising compressed nitrogen gas.", "The composition is factory prefilled in a borosilicate glass capsule which is strengthened by ion exchange.", "The glass capsule is sealed at the proximal end by a piston which is comprised of polytetrafluoroethylene which has been modified to improve its sealing properties.", "The glass capsule comprises an injection orifice at the distal end which is sealed after filling and during storage by a seal which is held in a seal carrier.", "The glass capsule is contained in a clear plastic sleeve which is frangibly attached to the seal carrier.", "The injector comprises a ram which comprises a pair of o-rings that seal the compress gas chamber of the energy source.", "Before actuation the ram is held in place against the urging of the compressed gas by a latch.", "The latch has a safe position, a ready position and a triggered position.", "The latch is disposed in a slot in the ram which has a latch safe section which is perpendicular to the ram axis, and a latch ready section at a slope to the ram axis and functions as a cam.", "The ram is separated from the piston by a gap, across which upon triggering the ram flies under the urging of the compressed gas, striking the piston.", "The injector comprised a safety lever, which when rotated moves the latch from the safe to the ready position and removes an additional blocking element.", "The level and the seal carrier are configured to ensure that the seal carrier must be removed prior to actuating the latch.", "The injector is partially contained in a housing.", "The housing comprises an aperture into which the latch moves under the urging of the cam surface when the device is actuated.", "The housing, after removal of the blocking element, is slidable relative to the internal components.", "Disposed between the housing and the internal components is a damping grease which prevents recoil of the internal components when the injector is actuated.", "To deliver the contents of the injector, first the seal carrier and seal is removed.", "Then the lever is actuated.", "The orifice is pressed against the desired injector site.", "This pressing causes the housing to slide relative to the internal components, exposing the latch to the aperture.", "The latch moves into the aperture under the urging of the cam, freeing the ram and triggering the device.", "Upon striking the piston, the ram creates a pressure spike in the composition.", "This portion of the delivery is the puncture phase, whereby composition leaving the capsule through the orifice creates a hole in the skin down to the subcutaneous layer.", "The ram then causes piston, under the urging of the compressed gas, to move through the capsule, expelling the remainder of the composition in a reduced pressure delivery phase.", "This embodiment, improvements to this embodiment, methods of manufacture, and methods of treatment are described in U.S. Pat.", "Nos.", "5,891,086; 5,957,886; 6,135,979; 7,776.007; 7,901,385; 8,267,903; 8,118,771; 8,241,243; 8,241,244; 8,287,489; 8,343,130; 7,150,297; 6,251,091; 6,174,304; 6,681,810; 6,280,410; 6,554,818; 6,620,135; 5,480,381; 7,231,945; 7,320,346; and 8,066,661; and PCT applications PCT/US2012/020654; PCT/US2011/051617, PCT/US2009/002533; and PCT/US2007/001403.The current disclosure describes various viscous compositions that can be delivered using a needle-free injector including the injector of U.S. Pat.", "No.", "5,891,086 to provide for subcutaneous (SC), intradermal (ID), intramuscular (IM) and other types of delivery.", "In some cases, the compositions are phase stable and/or require relatively low amounts of solvent.", "While not wishing to be bound by theory, this result may achieved by one or more of relatively low molecular weight polymer, relatively high L:G ratio, and polymers having alkoxy end groups.", "Compositions with reduced solvent are typically beneficial as they are generally more biocompatible.", "Studies conducted with the clinical composition described in Example 14 comprising risperidone, along with other compositions of similar chemical composition, indicate that the PK profile of SC risperidone-vehicle composition is consistently characterized by a sustained release of risperidone with low initial burst/no dose dump, a gradual decline in risperidone levels over time, and dose proportionality.", "Initial burst is a common phenomenon to most types of depot compositions and needs to be low enough such that the maximum observed concentration (Cmax) and the maximum exposure levels (i.e., area under the concentration-time curve [AUC] from time zero to 24 hours [AUC0-24 hr] and maximum observed concentration [Cmax]), do not exceed thresholds which result in adverse events.", "The compositions may be administered SC as a once monthly administration and may lead to improved patient compliance over short-acting oral tablets or biweekly IM administration.", "Risperidone compositions may not require oral dose supplementation because drug release begins immediately upon injection, leading to a less complicated initiation of product dosing and improved patient compliance.", "The present disclosure will be further illustrated by way of the following Examples.", "These examples are non-limiting and do not restrict the scope of the disclosure.", "Unless stated otherwise, all percentages, parts, etc.", "presented in the examples are by weight." ], [ "The present application is a Continuation of application Ser.", "No.", "15/399,142, filed Jan. 5, 2017, which is a Continuation of U.S. application Ser.", "No.", "14/995,658, filed Jan. 14, 2016, which is a Continuation of U.S. application Ser.", "No.", "14/204,529, filed Mar.", "11, 2014, which claims the priority under 35 U.S.C.", "§ 119(e) of U.S.", "Provisional Application No.", "61/776,336, filed Mar.", "11, 2013; and U.S.", "Provisional Application No.", "61/798,874, filed Mar.", "15, 2013; the disclosures of each of which are expressly incorporated by reference herein in their entireties.", "Compositions that provide controlled delivery of pharmaceutical active agent offer several advantages.", "For instance, controlled delivery can reduce or obviate the need for repeated dosing.", "Further, biodegradable matrices for drug delivery are useful because they obviate the need to remove a drug-depleted device.", "Noncompliance is prevalent with oral medications, e.g., in the treatment of schizophrenia and/or bipolar disorder.", "It has also been established that the risk for relapse can substantially increase with noncompliant patients.", "Long-acting medications, e.g., antipsychotic medications, have several advantages over short-acting oral tablets or IM agents when administered, e.g., for the treatment of chronic schizophrenia and/or bipolar disorder, e.g., assurance of compliance resulting in fewer relapses and re-hospitalizations.", "By contrast, some of the current long-acting products (e.g., Risperdal Consta® long-acting injection) requires supplementation, e.g., with oral risperidone, both at the initiation of IM dosing and in the event of a missed dose, due to a 3-week lag between the time of dose administration and initiation of drug release.", "All currently approved or development-stage, long-acting injections of antipsychotic drugs are administered intramuscularly, which is associated with the disadvantages of injection site pain and, for this class of drug, the more significant potential safety issue of inadvertent vascular contact resulting in systemic exposure of toxic levels of drug.", "This issue was most recently manifested during the development of Zyprexa® (olanzapine) long-acting-injection in which excessive sedation and even incidences of coma have been observed post injection.", "In contrast, dosage forms that have the potential for subcutaneous (SC) administration mitigate this potential safety issue.", "There remains, however, a need for compositions and methods that provide reproducible, controlled delivery of pharmaceutical active agents with low toxicity.", "Accordingly, there also remains a need for methods of making these compositions that provide reproducible, controlled delivery of pharmaceutical active agents with low toxicity.", "BRIEF DESCRIPTION OF THE DRAWINGS The present disclosure is further described in the description that follows, in reference to the noted plurality of non-limiting drawings, wherein: FIG.", "1 presents a longitudinal cross-section through a needle-free injector.", "FIGS.", "2a, b and c show the latch 6 and dispensing member 2 part of the needle-free injector from FIG.", "1 in the three stages ending in triggering.", "In (a) the latch 6 is in the first, or safe position.", "In (b) the latch 6 is in the second position, the non-safety, ready to trigger position.", "In (c), the latch 6 is in the third position, following triggering.", "FIG.", "3 illustrates a needle-free injector with one embodiment of the attachment for disengaging the safety mechanism.", "FIG.", "4 is a phase diagram of compositions including 65:35 DL-PLGA initiated with 1-hexanediol, which polymer has a weight average molecular weight of 4.3 to 5.1 kDa.", "FIG.", "5 is a phase diagram of compositions including 65:35 DL-PLGA initiated with 1-hexanediol, which polymer has a weight average molecular weight of 7.0 kDa.", "FIG.", "6 is a phase diagram of compositions including 65:35 DL-PLGA initiated with dodecanol, which polymer has a weight average molecular weight of 6.6 kDa.", "FIG.", "7 shows in vitro release, as measured using dialysis tubing, of olanzapine from various vehicles.", "FIG.", "8 shows in vitro release, as measured using dialysis tubing and a USP 2 apparatus, of olanzapine from a vehicle comprising sucrose acetate isobutyrate, propylene carbonate, and dodecanol-initiated poly(lactic acid)(glycolic acid).", "FIG.", "9 shows in vitro release, as measured using dialysis tubing and a USP 2 apparatus, of olanzapine from a vehicle comprising sucrose acetate isobutyrate, di methylsulfoxide, and dodecanol-initiated poly(lactic acid)(glycolic acid).", "FIG.", "10 shows in vitro release of exenatide from a vehicle comprising sucrose acetate isobutyrate, propylene carbonate, and poly(lactic acid)(glycolic acid) initiated with either octanol or 1-hexadecanol.", "FIG.", "11 shows in vitro release of exenatide from a vehicle comprising sucrose acetate isobutyrate, dimethylsulfoxide, and poly(lactic acid)(glycolic acid) initiated with either octanol or 1-hexadecanol.", "FIG.", "12 compares the real time settling behavior of risperidone particles in a composition based on N-methyl-pyrrolidone versus a composition based on propylene carbonate, both stored at 5° C. FIG.", "13 shows in vitro release of risperidone from a vehicle comprising sucrose acetate isobutyrate, N-methyl-pyrrolidone, and octanol-initiated poly(lactic acid)(glycolic acid).", "FIG.", "14 shows in vitro release of risperidone from a vehicle comprising sucrose acetate isobutyrate, N-methyl-pyrrolidone, and hexadecanol-initiated poly(lactic acid)(glycolic acid).", "FIG.", "15 shows in vitro release of risperidone from a vehicle comprising sucrose acetate isobutyrate, N-methyl-pyrrolidone, and dodecanol-initiated poly(lactic acid).", "FIG.", "16 shows the PK profile of risperidone in rats from compositions comprising risperidone, sucrose acetate isobutyrate, solvent (e.g., benzyl alcohol, ethanol, benzyl benzoate, and N-methyl-pyrrolidone), and polymer (e.g., poly(lactic acid) (PLA) and poly(lactic acid)(glycolic acid) (PLGA)).", "FIG.", "17 shows the active moiety (risperidone 9-hydroxy risperidone) PK profile following subcutaneous (SC) administration of the compositions shown in FIG.", "16.FIG.", "18 shows the PK profile of risperidone in individual rats following SC administration of one of the risperidone compositions shown in FIG.", "16.FIG.", "19 shows the molecular weight of polymer with respect to storage time in compositions with or without risperidone and with or without gamma radiation treatment.", "FIG.", "20 shows the PK profile of risperidone in rats from compositions comprising risperidone, sucrose acetate isobutyrate, solvent (N-methyl-pyrrolidone or dimethylsulfoxide), dodecanol-initiated poly(lactic acid)(glycolic acid), and optionally poly(lactic acid).", "FIG.", "21 shows the active moiety (risperidone+9-hydroxy risperidone) PK profile following SC administration of the compositions shown in FIG.", "20.FIG.", "22 shows the active moiety PK profile of individual rats following SC administration of one of the risperidone compositions shown in FIG.", "21.FIG.", "23 compares the PK profile of risperidone in rats from three compositions: (1) made with large particle risperidone and a vehicle including hexanediol-initiated poly(lactic acid)(glycolic acid) (PLGA); (2) made with small particle risperidone and a vehicle including hexanediol-initiated PLGA; and (3) made with small particle risperidone and a vehicle including dodecanol-initiated PLGA.", "FIG.", "24 is an expanded view of a portion of FIG.", "23.FIG.", "25 involves the same experiment as shown in FIGS.", "23 and 24, and compares the AUC from compositions: (1) made with small particle risperidone and a vehicle including hexanediol-initiated PLGA; and (2) made with small particle risperidone and a vehicle including dodecanol-initiated PLGA.", "FIG.", "26 shows pharmacokinetic profiles in dogs following SC administration of a 9 wt % risperidone composition.", "FIG.", "27 shows the effect of particle size on PK profile in dogs.", "FIG.", "28 shows the PK profile when 25 mg of risperidone in a vehicle comprising sucrose acetate isobutyrate (SAIB) was administered as a SC injection of 0.25 mL (100 mg/mL concentration) in the abdominal region of humans.", "FIG.", "29 shows the PK profile when 50 mg of risperidone in the SAIB based vehicle was administered via a DosePro® needle-free injector of 0.5 mL (100 mg/mL concentration) in the abdominal region of humans.", "FIG.", "30 shows the PK profile when 50 mg of risperidone in the SAIB based vehicle was administered as a subcutaneous (SC) injection of 0.5 mL (100 mg/mL concentration) in the abdominal region of humans.", "Unless otherwise stated, a reference to a compound or component includes the compound or component by itself, as well as in combination with other compounds or components, such as mixtures of compounds: As used herein, the singular forms “a,” “an,” and “the” include the plural reference unless the context clearly dictates otherwise.", "Before further discussion, a definition of the following terms will aid in the understanding of the present disclosure.", "“Administering” or “administration” means providing a drug to a subject in a manner that is pharmacologically useful.", "“Polymer” means a naturally occurring or synthetic compound made up of a linked series of repeat units.", "Polymer(s) include, but are not limited to, thermoplastic polymers and thermoset polymers.", "Polymer(s) may comprise linear polymers and/or branched polymers.", "Polymers may be synthesized from a single species of monomers, or may be copolymers that may be synthesized from more than one species of monomers.", "“Copolymer” includes terpolymers, etc.", "“Linear” means a polymer in which the molecules form long chains substantially without branches or cross-linked structures.", "“Weight average molecular weight” or “Mw” means the weighted average molecular weight of polymers of interest.", "It can be expressed at the first moment of a plot of the weight of polymer in each molecular weight range against molecular weight.", "In certain embodiments, weight-average molecular weight, Number-average molecular weight (Mn), and the molecular weight distribution (MWD=Mw/Mn) may be measured by gel permeation chromatography (GPC).", "GPC is a column fractionation method wherein polymer molecules in solutions are separated based on their sizes.", "The separated polymer molecules are observed by a detector to generate the GPC chromatogram, which is a plot of elution volume or time (related to molecular size) versus abundance.", "The GPC chromatogram may be integrated to determine Mw, Mn, and MWD.", "GPC samples of polymer(s) of interest, approximately 50 mg in 10 mL solvent, are filtered through a 0.2 μm Teflon filter before injection into the instrument.", "Injections of 50-200 μL are made to generate chromatograms.", "Chromatograms may be generated using various systems.", "In an embodiment, a system comprises an Agilent LC 1100 using Chemstation software.", "In another embodiment, a system comprises a Waters 510 pump, a Shimadzu CTO-10A column oven, and a Waters 410 differential refractometer.", "Data may be recorded directly to a PC via a Polymer Labs data capture unit using Caliber® software.", "A calibration curve may be generated using polystyrene standards.", "Mw, Mn, and MWD relative to polystyrene are calculated.", "Representative solvents for use in GPC comprise: chloroform, dichlormethane (methylene chloride), and tetrahydrofuran (THF).", "Representative column sets comprise: (1) two Polymer Labs Mixed C columns in series, (2) two Polymer Labs Mixed D columns in series, or (3) two Polymer Labs Mesopore columns in series.", "Representative polystyrene calibrants comprise: Polymer Labs Easical PS1 kit, Polymer Labs Easical PS2 kit, Polymer Labs S-L-10 kit.", "“Solvent” means material that is capable of dissolving other materials.", "“Solvent capacity” means amount(s) of the one or more solvents that dissolves the HVLCM and polymer in the composition to the same extent as would a hypothetical amount of N-methylpyrrolidone in the composition.", "Solvent capacity is expressed as that hypothetical weight percent of N-methylpyrrolidone in the composition, based on the total weight of the hypothetical composition that would contain the N-methylpyrrolidone.", "Thus, for example, a composition having a solvent capacity of about 20% would have sufficient amounts of one or more solvents to dissolve the HVLCM and linear polymer to the same extent as if about 20% by weight of NMP were added to the composition instead of the one or more solvents.", "If NMP were present as the one or more solvents in this embodiment, it would be present in an amount of about 20% by weight, based on the total weight of the composition.", "If the one or more solvents were poorer solvents for the HVLCM and linear polymer, then the one or more solvents would be present in an amount greater than about 20% by weight, based on the total weight of the composition.", "“Subject” is used interchangeably with “individual” and means any human or animal with which it is desired to practice the present disclosure.", "The term “subject” does not denote a particular age, and the present systems are thus suited for use with subjects of any age, such as infant, adolescent, adult and senior aged subjects In certain embodiments, a subject may comprise a patient.", "“Hydrophilic solvent” means substantially water-miscible solvents, preferably those when mixed with water in a ratio from 1:9 to 9:1 form a single-phase solution.", "In one aspect, the present composition comprises 25 wt % to 80 wt %, based on total weight of the composition, of a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere; a lactic-acid based polymer that is poly(lactic acid)(glycolic acid) comprising an alkoxy end group, the poly(lactic acid)(glycolic acid) having a lactic acid to glycolic acid molar ratio greater than 65:35; and an organic solvent.", "In another aspect, the present composition comprises 25 wt % to 80 wt %, based on total weight of the composition, of a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere; a lactic acid-based polymer comprising an alkoxy end group, wherein the lactic acid-based polymer has a weight average molecular weight ranging from 7000 Daltons to 30,000 Daltons; and an organic solvent.", "In yet another aspect, the present composition comprises a pharmaceutical active agent; 25 wt % to 80 wt %, based on total weight of the composition, of a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere; a lactic acid-based polymer comprising an alkoxy end group; and an organic solvent.", "In still another aspect, the present composition comprises particles comprising pharmaceutical active agent, the particles having a median particle size, as measured by laser diffraction, ranging from 0.5 micrometers to 10 micrometers; 25 wt % to 80 wt %, based on total weight of the composition, of a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere; a lactic acid-based polymer; and an organic solvent.", "In a further aspect, a gamma-irradiated composition comprises pharmaceutical active agent; and wherein the gamma-irradiated composition further comprises 25 wt % to 80 wt %, based on total weight of the composition, of a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere; a lactic acid-based polymer; and an organic solvent.", "In another aspect, the present composition comprises a pharmaceutical active agent that is risperidone or pharmaceutically acceptable salt thereof; a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere, a lactic acid-based polymer comprising an alkoxy end group, and an organic solvent in a ratio sufficient to maintain a therapeutically effective plasma concentration of the risperidone or pharmaceutically acceptable salt thereof for a period of at least 7 days when the composition is administered parenterally to a patient.", "In still another aspect, the present composition comprises a pharmaceutical active agent that is risperidone or pharmaceutically acceptable salt thereof; a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere, a lactic acid-based polymer comprising an alkoxy end group, and an organic solvent in a ratio such that when the composition is administered parenterally, an amount of pharmaceutical active agent released from the composition provides an AUC(0 to 1 day) that is less than 10%, such as less than 5%, of AUC(0 to 28 days).", "In a further aspect, the present composition comprises 5 wt % to 20 wt %, based on total weight of the composition, of particles comprising pharmaceutical active agent that is risperidone or pharmaceutically acceptable salt thereof, the particles having a median particle size, as measured by laser diffraction, ranging from 0.5 micrometer to 7 micrometers; 30 wt % to 60 wt %, based on total weight of the composition, of a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere, wherein the HVLCM is sucrose acetate isobutyrate; 5 wt % to 30 wt %, based on total weight of the composition, of a lactic acid based-polymer that is poly(lactic acid)(glycolic acid) comprising an alkoxy end group, the poly(lactic acid)(glycolic acid) having a lactic acid to glycolic acid molar ratio ranging from 95:5 to 60:40, the poly(lactic acid)(glycolic acid) having a weight average molecular weight ranging from 4000 Daltons to 15,000 Daltons; and 10 wt % to 40 wt %, based on total weight of the composition, of a solvent that is at least one member selected from N-methyl-pyrrolidone, propylene carbonate, and dimethylsulfoxide.", "In another aspect, the present composition comprises a pharmaceutical active agent that is risperidone or pharmaceutically acceptable salt thereof; means for extending a release profile of the pharmaceutical active agent when the composition is administered to a patient in need thereof.", "In a still further aspect, the present composition comprises a pharmaceutical active agent that is risperidone or pharmaceutically acceptable salt thereof; means for reducing settling of the pharmaceutical active agent within the composition.", "In another aspect, the present disclosure involves a method of reducing phase separation, comprising combining a pharmaceutical active agent with a means for achieving the reduction of phase separation.", "In a further aspect, the present disclosure involves a process comprising: wet milling a pharmaceutical active agent in an aqueous solution at less than 20° C. to form a milled pharmaceutical active agent; maintaining the milled pharmaceutical active agent at less than 5° C.; and lyophilizing the milled pharmaceutical active agent to form a lyophilized pharmaceutical active agent having a median particle size, as measured by laser diffraction, of less than 5 micrometers.", "In another aspect, a suspension is produced by wet milling a pharmaceutical active agent in an aqueous solution at less than 20° C. to form a milled pharmaceutical active agent; maintaining the milled pharmaceutical active agent at less than 5° C.; and lyophilizing the milled pharmaceutical active agent to form a lyophilized pharmaceutical active agent having a median particle size, as measured by laser diffraction, of less than 5 micrometers.", "In another aspect, a monophasic composition, comprises 25 wt % to 80 wt %, based on total weight of the composition, of sucrose acetate isobutyrate; a poly(lactic acid)(glycolic acid) comprising an alkoxy end group wherein the alkoxy end group consists of 12 carbons, the poly(lactic acid)(glycolic acid) having a lactic acid to glycolic acid molar ratio of at least 70:30; and an organic solvent that maintains the composition monophasic at 25° C. and 1 atmosphere.", "The pharmaceutical active agent may be dissolved or suspended in the composition.", "The particles comprising pharmaceutical active agent, which are used to make the disclosed compositions, typically have a median particle size, as measured by laser diffraction, ranging from 0.1 micrometer to 100 micrometers, such as 0.25 micrometers to 50 micrometers, 0.5 micrometers to 10 micrometers, 0.5 micrometer to 7 micrometers, or 1 micrometer to 5 micrometers.", "When particles are relatively large, e.g., median particle size, as measured by laser diffraction, above 10 micrometers, the particles have a tendency to fall out of suspension in lower viscosity formulations.", "When particles are relatively small, the particle size may change due to recrystallization, which affects the storage time dependence of the release profile.", "In the context of the present disclosure, the median particle size, as measured by laser diffraction, refers to the size of the particles before addition with the vehicle.", "Thus, the recited compositions are “made from” or “obtainable by combining” the particles comprising the pharmaceutical active agent and the one or more further specified components.", "In some cases, the pharmaceutical active agent has a solubility in the composition at 25° C. of less than about 100 mg/mL, such as less than about 50 mg/mL, less than about 10 mg/mL, less than about 5 mg/mL, less than about 1 mg/mL, or less than about 0.1 mg/mL.", "In one aspect, the pharmaceutical active agent comprises at least one member selected from peptide, protein, antibody, carbohydrate, small molecule, nucleic acid, and nucleoside.", "Representative pharmaceutical active agents include drug, peptide, protein, carbohydrate (including monosaccharides, oligosaccharides, and polysaccharides), nucleoprotein, mucoprotein, lipoprotein, synthetic polypeptide or protein, or a small molecule linked to a protein, antibody, glycoprotein, steroid, nucleic acid (any form of DNA, including cDNA, or RNA, or a fragment thereof), nucleotide, nucleoside, oligonucleotides (including antisense oligonucleotides), gene, lipid, hormone, mineral supplement, vitamin including vitamin C and vitamin E, or combinations of any of the above, that cause(s) a biological effect when administered in vivo to an animal, including but not limited to birds and mammals, including humans.", "Drug means any substance used internally or externally as a medicine for the treatment, cure, or prevention of a disease or disorder, and includes but is not limited to immunosuppressants, antioxidants, anesthetics, chemotherapeutic agents, steroids (including retinoids), hormones, antibiotics, antivirals, antifungals, antiproliferatives, antihistamines, anticoagulants, antiphotoaging agents, melanotropic peptides, nonsteroidal and steroidal anti-inflammatory compounds, antipsychotics, and radiation absorbers, including UV-absorbers.", "In one embodiment disclosed herein, the pharmaceutical active agent is a vaccine and the substance to be delivered is an antigen.", "The antigen can be derived from a cell, bacteria, or virus particle, or portion thereof.", "As defined herein, antigen may be a protein, peptide, polysaccharide, glycoprotein, glycolipid, nucleic acid, or combination thereof, which elicits an immunogenic response in an animal, for example, a mammal, bird, or fish.", "As defined herein, the immunogenic response can be humoral or cell-mediated.", "In the event the material to which the immunogenic response is to be directed is poorly antigenic, it may be conjugated to a carrier such as albumin or to a hapten, using standard covalent binding techniques, for example, with one of the several commercially available reagent kits.", "Examples of antigens include viral proteins such as influenza proteins, human immunodeficiency virus (HIV) proteins, and hepatitis A, B, or C proteins, and bacterial proteins, lipopolysaccharides such as gram negative bacterial cell walls and Neisseria gonorrhea proteins, and parvovirus.", "Non-limiting examples of pharmaceutical active agents include anti-infectives such as nitrofurazone, sodium propionate, antibiotics, including penicillin, tetracycline, oxytetracycline, chlorotetracycline, bacitracin, nystatin, streptomycin, neomycin, polymyxin, gramicidin, chloramphenicol, erythromycin, and azithromycin; sulfonamides, including sulfacetamide, sulfamethizole, sulfamethazine, sulfadiazine, sulfamerazine, and sulfisoxazole, and anti-virals including idoxuridine; antiallergenics such as antazoline, methapyritene, chlorpheniramine, pyrilamine prophenpyridamine, hydrocortisone, cortisone, hydrocortisone acetate, dexamethasone, dexamethasone 21-phosphate, fluocinolone, triamcinolone, medrysone, prednisolone, prednisolone 21-sodium succinate, and prednisolone acetate; desensitizing agents such as ragweed pollen antigens, hay fever pollen antigens, dust antigen and milk antigen; vaccines such as smallpox, yellow fever, distemper, hog cholera, chicken pox, antivenom, scarlet fever, dyptheria toxoid, tetanus toxoid, pigeon pox, whooping cough, influenzae, rabies, mumps, measles, poliomyelitic, and Newcastle disease; decongestants such as phenylephrine, naphazoline, and tetrahydrazoline; miotics and anticholinesterases such as pilocarpine, esperine salicylate, carbachol, diisopropyl fluorophosphate, phospholine iodide, and demecarium bromide; parasympatholytics such as atropine sulfate, cyclopentolate, homatropine, scopolamine, tropicamide, eucatropine, and hydroxyamphetamine; sympathomimetics such as epinephrine; sedatives and hypnotics such as pentobarbital sodium, phenobarbital, secobarbital sodium, codeine, (a-bromoisovaleryl) urea, carbromal; psychic energizers such as 3-(2-aminopropyl) indole acetate and 3-(2-aminobutyl) indole acetate; tranquilizers such as reserpine, chlorpromayline, and thiopropazate; androgenic steroids such as methyl-testosterone and fluorymesterone; estrogens such as estrone, 17-.beta.-estradiol, ethinyl estradiol, and diethyl stilbestrol; progestational agents such as progesterone, megestrol, melengestrol, chlormadinone, ethisterone, norethynodrel, 19-norprogesterone, norethindrone, medroxyprogesterone and 17-.beta.-hydroxy-progesterone; humoral agents such as the prostaglandins, for example PGE.sub.1, PGE.sub.2 and PGF.sub.2; antipyretics such as aspirin, sodium salicylate, and salicylamide; antispasmodics such as atropine, methantheline, papaverine, and methscopolamine bromide; antimalarials such as the 4-aminoquinolines, 8-aminoquinolines, chloroquine, and pyrimethamine, antihistamines such as diphenhydramine, dimenhydrinate, tripelennamine, perphenazine, and chlorphenazine; cardioactive agents such as dibenzhydroflume thiazide, flumethiazide, chlorothiazide, and aminotrate; antipsychotics including typical and atypical antipsychotics, wherein the atypical antipsychotics comprise risperidone, paliperidone, or olanzapine; nutritional agents such as vitamins, natural and synthetic bioactive peptides and proteins, including growth factors, cell adhesion factors, cytokines, and biological response modifiers; together with pharmaceutically acceptable salts of the above.", "The pharmaceutical active agent is typically included in the composition in an amount sufficient to deliver to the host animal or plant an effective amount to achieve a desired effect.", "The amount of pharmaceutical active agent incorporated into the composition depends upon the desired release profile, the concentration of pharmaceutical active agent required for a biological effect, and the desired period of release of the pharmaceutical active agent.", "The concentration of pharmaceutical active agent in the composition will also depend on absorption, inactivation, and excretion rates of the pharmaceutical active agent as well as other factors known to those of skill in the art.", "It is to be noted that dosage values will also vary with the severity of the condition to be alleviated.", "It is to be further understood that for any particular subject, specific dosage regimens should be adjusted over time according to the individual need and the professional judgment of the person administering or supervising the administration of the disclosed compositions, and that the concentration ranges set forth herein are exemplary only and are not intended to limit the scope or practice of the present disclosure.", "The compositions may be administered in one dosage, or may be divided into a number of smaller doses to be administered at varying intervals of time.", "In some cases, the pharmaceutical active agent comprises an antipsychotic, such as an atypical antipsychotic.", "Examples of anti-psychotic drugs include, but are not limited to metabotropic glutamate receptor 2 agonists, glycine transporter 1 inhibitors, partial agonists of dopamine receptors, chlorpromazine, fluphenazine, mesoridazine, perphenazine, prochlorperazine, promazine, thioridazine/sulforidazine, trifluoperazine, butyrophenones (azaperone, benperidol, droperidol, haloperidol), thioxanthenes (flupentixol, chlorprothixene, thiothixene, zuclopenthixol), diphenylbutylpiperidines (fluspirilene, penfluridol, pimozide, loxapine), butyrophenones (melperone), indoles (sertindole, ziprasidone, molidone), benzamides (sulpiride, remoxipride, amisulpride), diazepines/oxazepines/thiazepines (clozapine, olanzapine, quetiapine), aripiprazole, risperidone, paliperidone, zotepine), amisulpride, asenapine, iloperidone, lurasidone, cannabidiol, tetraenazine, and L-theanine, including pharmaceutically acceptable salts, solvates, bases, and ester forms thereof.", "Combinations of two or more of these compounds, or combinations with other compounds are included in the scope of the disclosure.", "For instance, the pharmaceutical active agent may comprise at least one member selected from chlorpromazine, fluphenazine, mesoridazine, perphenazine, prochlorperazine, promazine, thioridazine, sulforidazine, trifluoperazine, molindone, azaperone, benperidol, droperidol, haloperidol, flupentixol, chlorprothixene, thiothixene, zuclopenthixol, fluspirilene, penfluridol, pimozide, loxapine, melperone, sertindole, ziprasidone, sulpiride, remoxipride, amisulpride, clozapine, olanzapine, quetiapine, aripiprazole, risperidone, paliperidone, zotepine, amisulpride, asenapine, iloperidone, lurasidone, cannabidiol, tetraenazine, and L-theanine, or pharmaceutically acceptable salt thereof.", "In some cases, the pharmaceutical active agent comprises risperidone or pharmaceutically acceptable salt thereof.", "Exemplary salts include hydrochloride, phosphate, citrate, maleate, mesylate, pamoate, and naphthaline-2-sulfonate monohydrate.", "For instance, representative salts include risperidone pamoate, risperidone naphthaline-2-sulfonate, paliperidone palmitate.", "In some cases, the salt is lipophilic.", "The pharmaceutical active agent is typically present in the compositions in the range from 0.5 wt % to 50 wt %, such as 0.5 wt % to 30 wt %, 1 wt % to 25 wt %, 1 wt % to 20 wt %, 2 wt % to 20 wt %, or 5 wt % to 20 wt %, based on total weight of the composition.", "For potent pharmaceutical active agents, such as growth factors, typical ranges include less than 1 wt %, and further even less than 0.0001 wt %.", "The compositions can include one or more non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere.", "For instance, the HVLCM may have a viscosity of at least at least 10,000 cP, at least 15,000 cP, at least 20,000 cP, at least 25,000 cP, or at least 50,000 cP at 37° C. The term non-water soluble refers to a material that is soluble in water to a degree of less than one percent by weight under ambient conditions.", "In some cases, the HVLCM significantly decreases in viscosity when mixed with a solvent to form a low viscosity liquid carrier material (“LVLCM”) that can be mixed with a substrate for controlled delivery.", "The LVLCM/substrate composition is typically easier to place in the body than a HVLCM/substrate composition, because it flows more easily into and out of syringes or other implantation means, and can easily be formulated as an emulsion.", "The LVLCM can have any desired viscosity.", "It has been found that a viscosity range for the LVLCM of less than approximately 2000 cP, such as less than 1000 cP, is typically useful for in vivo applications.", "In one embodiment, sucrose acetate isobutyrate (“SAIB”), a sucrose molecule nominally esterified preferably with two acetic acid and six isobutyric acid moieties, is used as the HVLCM.", "SAIB is orally non-toxic and is currently used as to stabilize emulsions in the food industry.", "It is a very viscous liquid and has an unusual property that there is a dramatic change in viscosity with small additions of heat or with the addition of solvents.", "It is soluble in a large number of biocompatible solvents.", "When in solution or in an emulsion, SAIB can be applied via injection or an aerosol spray.", "SAIB is compatible with cellulose esters and other polymers that can affect the rate of delivery of the substance.", "In some embodiments of the disclosure, the HVLCM can be stearate esters such as those of propylene glycol, glyceryl, diethylaminoethyl, and glycol, stearate amides and other long-chain fatty acid amides, such as N,N′-ethylene distearamide, stearamide MEA and DEA, ethylene bistearamide, cocoamine oxide, long-chain fatty alcohols, such as cetyl alcohol and stearyl alcohol, long-chain esters such as myristyl myristate, beheny erucate, and glyceryl phosphates.", "In a particular embodiment, the HVLCM is acetylated sucrose distearate (Crodesta A-10).", "Additional materials suitable for use as the HVLCM are disclosed in US Patent Application Publication US 2004/0101557 by Gibson et al.", "The amount of HVLCM in a composition will depend on the desired properties of a composition and the solvent capacity of the chosen solvent.", "If the chosen solvent has poor solvent capacity performance, then the actual amount of solvent may be large, with a corresponding reduction in the amount of HVLCM in the composition.", "The HVLCM is typically present in controlled delivery compositions in an amount ranging from about 10 wt % to about 99.5 wt %, such as from 25 wt % to 95 wt %, from 25 wt % to 85 wt %, from 30 wt % to 60 wt %, and from 45 wt % to 55 wt %, relative to the total weight of the composition.", "The compositions can include one or more polymer, such as a lactic-acid based polymer.", "The lactic-acid based polymer is typically biodegradable and biocompatible.", "The lactic-acid based polymer can be used to alter the release profile of the pharmaceutical active agent to be delivered, to add integrity to the composition, or to otherwise modify the properties of the composition.", "An exemplary property of the composition is the miscibility or solubility of the polymer in the composition with the HVLCM.", "In situations where the polymer is not miscible or soluble in the composition with the HVLCM, phase separation of the polymer and the HVLCM may occur.", "Once this occurs, it may be very difficult to remix the polymer and the HVLCM, especially at the point of use.", "Should improper remixing of the composition occur, it might not release drug in a desired manner.", "Additionally, the compositions might be difficult to administer.", "Accordingly, compositions that have high miscibility or solubility of the polymer in the composition with the HVLCM are desirable.", "The lactic-acid based polymer may be linear or branched.", "The lactic acid-based polymer may be unsaturated or saturated.", "The lactic-acid based polymer may comprise a homopolymer, i.e., poly(lactic acid), which includes polylactide for purposes of the present disclosure.", "Alternatively, the lactic acid-based polymer may comprise a copolymer.", "In addition to lactic acid, the polymer may also comprise repeat units of other suitable materials, including but not limited to glycolic acid repeat units, glycolide repeat units, polyethylene glycol repeat units, caprolactone repeat units, valerolactone repeat units, and the like.", "For instance, the lactic acid-based polymer may comprise poly(lactic acid)(glycolic acid), which includes poly(lactide)(glycolide) for purposes of the present disclosure.", "The poly(lactic acid)(glycolic acid) typically has a lactic acid to glycolic acid molar ratio ranging from 100:0 to 40:60, such as from 95:5 to 60:40, 65:35 to 90:10, or 75:25 to 85:15.In some cases, the poly(lactic acid)(glycolic acid) has a lactic acid to glycolic acid molar ratio greater than 65:35, such as greater than 70:30, or greater than 75:25.Polymers with higher L:G ratio tend to be more compatible with sucrose acetate isobutyrate and tend to provide longer release profiles.", "The lactic acid-based polymer typically has a weight average molecular weight ranging from 1000 Daltons to 30,000 Daltons, such as from 4000 Daltons to 15,000 Daltons, further such as from 7000 Daltons to 30,000 Daltons, even further such as 7000 Daltons to 15,000 Daltons, and as an even further example, from 5000 Daltons to 10,000 Daltons.", "The weight average molecular weight may be less than or equal to about 15,000 Daltons, such as less than or equal to about 12,500 Daltons, or less than or equal to about 10,000 Daltons.", "Polymers with lower molecular weight tend to be more miscible with sucrose acetate isobutyrate and tend to provide shorter release profiles.", "The lactic acid-based polymer may have an alkoxy end group.", "For instance, the lactic acid-based polymer may comprise an alkoxy end group that consists of 8 to 24 carbons, such as 12 carbons.", "Initiators for the polymers include but are not limited to diol initiators including 1,6-hexanediol, 1,2-propanediol, 1,3-propanediol, 1,4-butanediol and the like; diol initiators including difunctional polyethylene glycol)s (PEGs); monofunctional alcohol initiators including 1-dodecanol, methyl lactate, ethyl lactate and the like; monofunctional PEGs including methoxy(polyethylene glycol) (mPEG); and other initiators including water, glycolic acid, lactic acid, citric acid, and the like.", "In some cases, the lactic acid-based polymer is initiated with a member selected from fatty alcohol and dial.", "For instance, the lactic-acid based polymer may be initiated with 1,6-hexanediol or with dodecanol.", "Compositions including polymers initiated dodecanol tend to provide a larger region of solubility than compositions including the polymer initiated with 1-hexanediol.", "As a result, compositions including polymer initiated with dodecanol, which results in a polymer having an alkoxy end group (which consists of 12 carbons), can require less solvent and/or can tend to be more resistant to phase separation.", "Surprisingly, compositions comprising polymers comprising alkoxy end group and made from small drug particles, e.g., median particle size, as measured by laser diffraction, of 10 μm or less, can have lower drug burst in vivo relative to compositions using other polymers.", "For example, compositions comprising dodecanol-initiated PLGA and made from risperidone in the form of small particles were shown to have a lower drug burst than compositions based on hexanediol-initiated PLGA.", "The lactic acid-based polymer is typically present in an amount ranging from 1 wt % to 50 wt %, such as from 1 wt % to 45 wt %, from 5 wt % to 35 wt %, from 5 \\A % to 30 wt %, from 5 wt % to 25 wt %, from 10 wt % to 25 wt %, from 15 wt % to 45 wt %, or such as from 15 wt % to about 35 wt %, based on total weight of the composition.", "The compositions can include one or more organic solvents.", "Solvents used in the practice of the present disclosure are typically biocompatible, polar, non-polar, hydrophilic, water miscible, water soluble, and/or non-toxic.", "In some embodiments, the pharmaceutical active agent is soluble in the solvent.", "The solvents used to inject the disclosed compositions into animals should not cause significant tissue irritation or necrosis at the site of implantation, unless irritation or necrosis is the desired effect.", "The solvent is typically water miscible and/or water soluble, so that it will diffuse into bodily fluids or other aqueous environment, causing the composition to assume a more viscous form.", "Certain solvents that are not water miscible and/or not water soluble may also be used in the practice of the disclosure.", "The one or more solvents should be biocompatible, which may eliminate some solvents from use in the disclosed compositions.", "In an embodiment, the one or more solvents should be good solvents for both the polymer and HVLCM.", "The solvent may comprise at least one member selected from N-methyl-pyrrolidone (NMP), dimethylsulfoxide (DMSO), propylene carbonate (PC), benzyl alcohol (BA), benzyl benzoate (BB), dimethylacetamide, caprylic/capric triglyceride, polyoxyethylene ester of 12-hydroxystearic acid, ethanol, ethyl lactate, glycofurol, propylene glycol, acetone, methyl acetate, ethyl acetate, methyl ethyl ketone, triacetin, dimethylformamide, tetrahydrofuran, caprolactam, decylmethylsulfoxide, oleic acid, tocopherol, linoleic acid, oleic acid, ricinoleic acid, pyrrolidone, diethyl phthalate, isopropylidene glycerol, and 1-dodecylazacycloheptan-2-one.", "In some cases, the solvent comprises at least one member selected from N-methyl-pyrrolidone (NMP), dimethylsulfoxide (DMSO), propylene carbonate (PC), benzyl benzoate (BB), dimethylacetamide, caprylic/capric triglyceride, polyoxyethylene ester of 12-hydroxystearic acid, ethanol, ethyl lactate, glycofurol, propylene glycol, acetone, methyl acetate, ethyl acetate, methyl ethyl ketone, triacetin, dimethylformamide, tetrahydrofuran, caprolactam, decylmethylsulfoxide, oleic acid, tocopherol, linoleic acid, oleic acid, ricinoleic acid, pyrrolidone, diethyl phthalate, isopropylidene glycerol, and 1-dodecylazacycloheptan-2-one.", "In some cases, the solvent comprises N-methyl-pyrrolidone.", "In other cases, the solvent comprises DMSO.", "In still other cases, the solvent comprises propylene carbonate.", "Propylene carbonate improves the settling and allows longer shelf life and storage at refrigerated conditions of 2-8° C. When SAIB is used as the HVLCM, the typical solvents include ethanol, dimethylsulfoxide, ethyl lactate, ethyl acetate, benzyl alcohol, triacetin, N-methylpyrrolidone, propylene carbonate, and glycofurol.", "Particularly preferred solvents include ethanol, dimethylsulfoxide, ethyl lactate, ethyl acetate, triacetin, N-methylpyrrolidone, propylene carbonate, and glycofurol.", "SAIB is not miscible with glycerol, corn oil, peanut oil, 1,2-propanediol, polyethylene glycol (PEG200), super refined sesame oil, and super refined peanut oil.", "Accordingly, the latter group of solvents is not preferred for use with SAIB.", "In certain cases, the solvent is not an alcohol.", "For instance, in some cases, the solvent is not ethanol.", "In other cases, the solvent is not benzyl alcohol.", "Thus, the composition may be free of alcohol, ethanol, and/or benzyl alcohol.", "The solvent typically has a solvent capacity of greater than or equal to 25%, such as greater than or equal to 20%, greater than or equal to about 15%, or greater than or equal to about 10%.", "The solvent is typically present in an amount ranging from 1 wt % to 60 wt %, such as from 1 wt % to 50 wt %, 1 wt % to 40 wt %, 5 wt % to 35 wt %, 5 wt % to 30 wt %, 10 wt % to 50 wt %, or 20 wt % to 40 wt %, based on total weight of the composition.", "Minimizing total solvent content of the compositions is generally biologically desirable.", "Increasing solvent content, however, can move a HVLCM/linear polymer/solvent composition from phase separation to single phase behavior.", "In some embodiments, a weight ratio of the HVLCM to the lactic acid-based polymer to the solvent ranges from 1:0.066-1.3:0.3-1.7, such as 1:0.25-0.5:0.4-0.8.In one embodiment of the disclosure, a composition comprises 5 wt % to 20 wt %, based on total weight of the composition, of particles comprising a pharmaceutical active agent that is risperidone or a pharmaceutically acceptable salt thereof, the particles having a median particle size, as measured by laser diffraction, ranging from 0.5 micrometer to 7 micrometers; and the composition further comprises from 30 wt % to 60 wt %, based on total weight of the composition, of sucrose acetate isobutyrate; from 5 wt % to 30 wt %, based on total weight of the composition, of a lactic acid based-polymer that is poly(lactic acid)(glycolic acid) comprising an alkoxy end group, the poly(lactic acid)(glycolic acid) having a lactic acid to glycolic acid molar ratio ranging from 95:5 to 60:40, the poly(lactic acid)(glycolic acid) having a weight average molecular weight ranging from 4000 Daltons to 15,000 Daltons; and 10 wt % to 40 wt %, based on total weight of the composition, of a solvent that is at least one member selected from N-methyl-pyrrolidone, propylene carbonate, and di methylsulfoxide.", "A variety of additives can optionally be included in the compositions to modify the properties of the compositions as desired.", "The additives can be present in any amount that is sufficient to impart the desired properties to the compositions.", "The amount of additive used will in general be a function of the nature of the additive and the effect to be achieved, and can be easily determined by one of skill in the art.", "When present, additive(s) are typically present in the compositions in an amount in the range from about 0.1 percent to about 20 percent by weight, relative to the total weight of the composition, and more typically, is present in the composition in an amount in the range from about 1, 2, or 5 percent to about 10 percent by weight, relative to the total weight of the composition.", "Certain additives, such as buffers, may be present only in small amounts in the relative to the total weight of the composition.", "Another additive for use with the present compositions are non-biodegradable polymers.", "Non-limiting examples of non-erodible polymers which can be used as additives include: polyacrylates, ethylene-vinyl acetate polymers, cellulose and cellulose derivatives, acyl substituted cellulose acetates and derivatives thereof, non-erodible polyurethanes, polystyrenes, polyvinyl chloride, polyvinyl fluoride, poly(vinyl imidazole), chlorosulphonated polyolefins, and polyethylene oxide.", "Exemplary non-biodegradable polymers include polyethylene, polyvinyl pyrrolidone, ethylene vinylacetate, polyethylene glycol, cellulose acetate butyrate (“CAB”) and cellulose acetate propionate (“CAP”).", "A further class of additives which can be used in the disclosed compositions are natural and synthetic oils and fats.", "Oils derived from animals or from plant seeds of nuts typically include glycerides of the fatty acids, chiefly oleic, palmitic, stearic, and linolenic.", "As a rule the more hydrogen the molecule contains, the thicker the oil becomes.", "Non-limiting examples of suitable natural and synthetic oils include vegetable oil, peanut oil, medium chain triglycerides, soybean oil, almond oil, olive oil, sesame oil, peanut oil, fennel oil, camellia oil, corn oil, castor oil, cotton seed oil, and soybean oil, either crude or refined, and medium chain fatty acid triglycerides.", "Fats are typically glyceryl esters of higher fatty acids such as stearic and palmitic.", "Such esters and their mixtures are solids at room temperatures and exhibit crystalline structure.", "Lard and tallow are examples.", "In general oils and fats increase the hydrophobicity of the composition, slowing degradation and water uptake.", "Another class of additives which can be used in the disclosed compositions comprise carbohydrates and carbohydrate derivatives.", "Non-limiting examples of these compounds include monosaccarides (simple sugars such as fructose and its isomer glucose (dextrose); disaccharides such as sucrose, maltose, cellobiose, and lactose; and polysaccarides.", "Other additives, such as preservatives, stabilizers, anti-oxidants, coloring agents, isotonic agents, humectants, sequesterants, vitamins and vitamin precursors, surfactants and the like, may be added as needed.", "Examples of preservatives include paraben derivatives, such as methyl paraben and propyl paraben.", "Examples of anti-oxidants include butyl hydroxyanisole, butyl hydroxytoluene, propyl gallate, vitamin E acetate, and purified hydroquinone.", "Humectants include sorbitol.", "Sequesterants include citric acid.", "In some aspects, the composition may further comprise at least one member selected from viscosity enhancers, antioxidants, preservatives, and particle stabilizers.", "For instance, the composition may comprise at least one member selected from ricinoleic acid, polyoxyethylene-polyoxypropylene block copolymer, polyvinylpyrrolidone, polyethyeleneglycol (e.g., PEG4000), and Cremophor EL® ethoxylated castor oil which includes polyethylene glycol ether.", "As noted above, an aspect of the compositions according to the present disclosure is the miscibility or solubility of the polymer in the composition with the HVLCM.", "In situations where the polymer is not miscible or soluble in the composition with the HVLCM, phase separation of the polymer and the HVLCM in the composition may occur.", "Once this occurs, it may be very difficult to remix the polymer and the HVLCM, especially at the point of use.", "Should improper or no remixing occur, undesirably wide variations in release performance might result.", "Accordingly, compositions that have high miscibility or solubility of the polymer in the composition with the HVLCM are desirable.", "The present compositions typically possess high miscibility or solubility of the polymer in the composition with the HVLCM.", "In one aspect of the disclosure, the composition may comprise the HVLCM, the polymer, one or more good solvents for the polymer, and one or more good solvents for the HVLCM, with the resultant composition being a single phase.", "Solubility and phase separation of various HVLVM/linear polymer/solvent composition may be investigated by visual techniques well known to those skilled in the art.", "For compositions with significant instability or tendency to phase-separate, the linear polymer may absorb solvent but remain as a separated, very viscous layer or phase in the composition.", "Other compositions might be rendered into a uniform clear solution by sufficient heating and mixing.", "However, when cooled to room temperature, two clear liquid phases may form.", "Sometimes, the two clear layers may not be easy to detect, thus requiring strong light and a thorough inspection of the composition to discern the boundary between the two phases.", "In a number of cases, compositions may appear clear and uniform on initial cooling to room temperature, but when left quiescent at room temperature for a period of several days or greater, the compositions may separate into two phases.", "For compositions that are at the border of phase separation, the composition may turn cloudy and sometimes slowly separate into two phases.", "The HVLCM, the lactic acid-based polymer, and the solvent are typically monophasic when stored at 25° C. for a period of time, such as 7 days, for 1 month, for 24 months, or longer.", "In one embodiment, the composition is monophasic and comprises: from 25 wt % to 80 wt %, based on total weight of the composition, of sucrose acetate isobutyrate; a poly(lactic acid)(glycolic acid) comprising an alkoxy end group wherein the alkoxy end group consists of 12 carbons, the poly(lactic acid)(glycolic acid) having a lactic acid to glycolic acid molar ratio of at least 70:30; and an organic solvent that maintains the composition monophasic at 25° C. and 1 atmosphere.", "In another aspect of the disclosure, a method of reducing phase separation comprises combining: a pharmaceutical active agent, a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere; a lactic acid-based polymer; and an organic solvent.", "In another aspect of the disclosure, a method of reducing phase separation, comprises combining: a pharmaceutical active agent with a means for achieving the reduction of phase separation.", "The composition typically has a viscosity of less than 5000 cP, such as less than 3000 cP.", "For instance, the viscosity may range from 50 cP to 2000 cP, such as 500 cP to 1500 cP.", "In one aspect, the composition comprises a pharmaceutical active agent that is risperidone or a pharmaceutically acceptable salt thereof; and means for extending a release profile of the pharmaceutical active agent when the composition is administered to a patient in need thereof.", "In another aspect of the disclosure, the composition comprises a pharmaceutical active agent that is risperidone or a pharmaceutically acceptable salt thereof; and a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere, a lactic acid-based polymer comprising an alkoxy end group, and an organic solvent in a ratio sufficient to maintain a therapeutically effective plasma concentration of the risperidone or pharmaceutically acceptable salt thereof for a period of at least 7 days when the composition is administered parenterally to a patient.", "The period may be at least 14 days, such as at least 21 days, at least 28 days, or at least 84 days.", "In another aspect, the composition comprises risperidone or pharmaceutically acceptable salt thereof; and a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere, a lactic acid-based polymer comprising an alkoxy end group, and an organic solvent in a ratio such that when the composition is administered parenterally, an amount of pharmaceutical active agent released from the composition provides an AUC(0 to 1 day) that is less than 20%, such as less than 15%, less than 10%, or less than 5%, of AUC(0 to 28 days).", "In yet another aspect, the composition comprises a pharmaceutical active agent, wherein when the composition is administered parenterally, an amount of pharmaceutical active agent released from the composition at 4 weeks of administration to a patient ranges from 20% to 100%, such as 20% to 75%, 30% to 60%, or 40% to 50%, of a total amount of the pharmaceutical active agent in the composition.", "In one aspect of the disclosure, the composition comprises a pharmaceutical active agent, wherein when the composition is placed in phosphate buffered saline at 37° C., an amount of pharmaceutical active agent released from the composition at 4 weeks of placement in the phosphate buffered saline ranges from 20% to 100%, such as 30% to 90%, 40% to 80%, or 50% to 70%, of a total amount of the pharmaceutical active agent in the composition.", "In yet another aspect of the disclosure, the composition comprises a pharmaceutical active agent, wherein when the composition is placed in phosphate buffered saline at 37° C., an amount of pharmaceutical active agent released from the composition at 24 hours after placement in the phosphate buffered saline is less than 20%, such as less than 15%, less than 10%, or less than 5%, of an amount released at 28 days.", "Further, the amount of pharmaceutical active agent released at 28 days after placement in the phosphate buffered saline at 37° C. may be greater than 50%, such as greater than 60%, or greater than 70%, of a total amount of pharmaceutical active agent in the composition.", "In another aspect of the disclosure, the composition comprises a pharmaceutical active agent, wherein when the composition is administered parenterally, an amount of pharmaceutical active agent released from the composition provides an AUC(0 to 1 day) that is less than 20%, such as less than 15%, less than 10%, or less than 5%, of AUC(0 to 28 days).", "In still another aspect, the composition comprises a pharmaceutical active agent, wherein when the composition is administered parenterally, an amount of pharmaceutical active agent released from the composition provides an AUC(0 to 1 day) that is less than 20%, such as less than 10%, or less than 5%, of AUCinf.", "In one embodiment of the disclosure, a method of improving reproducibility of a release profile, comprises combining: a pharmaceutical active agent, a non-polymeric, non-water soluble high viscosity liquid carrier material (HVLCM) having a viscosity of at least 5000 cP at 37° C. that does not crystallize neat at 25° C. and 1 atmosphere; a lactic acid-based polymer; and an organic solvent.", "In one aspect, the composition comprises a pharmaceutical active agent that is risperidone or a pharmaceutically acceptable salt thereof; and means for reducing settling of the pharmaceutical active agent within the composition.", "In another aspect, the composition comprises a pharmaceutical active agent, wherein when 2 mL of the composition is placed in an upright 2 mL vial for 10 months at 5° C., a difference between top concentration and bottom concentration divided by initial concentration is less than 35%, such as less than 15% or less than 10%.", "The top concentration is concentration of pharmaceutical active agent of the top 10% of the composition within the upright 2 mL vial after the 10 months storage.", "The bottom concentration is concentration of pharmaceutical active agent of the bottom 10% of the composition within the upright 2 mL vial after the 10 months storage.", "The initial concentration is concentration of pharmaceutical active agent of the composition before the 10 months storage.", "In one aspect, the composition is a unit dosage form comprising from 0.01 mg to 500 mg, such as 1 mg to 250 mg or 10 mg to 100 mg of the pharmaceutical active agent.", "The composition may be contained within a vial, a syringe, a pre-filled syringe, an autoinjector, a needle-free injector.", "The composition may be contained within a receptacle.", "The compositions of the present disclosure may be made by any of the various methods and techniques known and available to those skilled in the art in view of the directions supplied in this specification.", "For instance, polymer (DD, PLGA) may be dissolved in propylene carbonate.", "SAIB may be added to the mixture and allowed to dissolve and mix to make the vehicle (SAIB/PC/PLGA).", "Risperidone powder (e.g., produced by agitator bead milling and lyophilization) may then be added to the vehicle, and the suspension may be mixed using a homogenizer (or other suitable mixer).", "In certain embodiments, first combine room temperature solvent(s), room temperature polymer and HVLCM heated to 80° C. Next, mix at 60-80° C. for a period of several hours to overnight (8-16 hours) until the composition is well-mixed.", "In other embodiments, dissolve the linear polymer in all of the solvent(s).", "Add hot HVLCM (heated at up to 80° C.).", "Then, mix at temperature of room temperature to 80° C. for 1 hour to overnight (8-16 hours) until the composition is well-mixed.", "In yet other embodiments, dissolve the linear polymer in some of the solvent(s).", "Mix the remainder of the solvent(s) with the HVLCM.", "Add hot HVLCM/solvent mixture (heated at up to 80° C.) to the linear polymer/solvent(s) mixture.", "Then, mix at temperatures that may range from room temperature to 80° C. for 1 hour to overnight (8-16 hours), until the composition is well-mixed.", "The compositions are typically prepared at temperatures above room temperature.", "Once mixed, the compositions may be cooled back to room temperature and initially observed for cloudiness (indication of incipient phase separation), the presence of two liquid layers (usually of low to moderate viscosity) or the presence of a viscous layer underneath a less viscous layer.", "The compositions may then be left at room temperature for a significant period (usually one week or greater) and observed again for cloudiness, separation into two layers of moderate viscosity or the presence of a viscous layer.", "A surprising result of the present disclosure is the ability to obtain small particles comprising pharmaceutical active agent, e.g., risperidone, via wet milling.", "In one aspect, a process comprises wet milling a pharmaceutical active agent in an aqueous solution at less than 20° C. to form a milled pharmaceutical active agent; maintaining the milled pharmaceutical active agent at less than 5° C.; and lyophilizing the milled pharmaceutical active agent to form a lyophilized pharmaceutical active agent having a median particle size, as measured by laser diffraction, of less than 10 micrometers, such as less than 5 micrometers, less than 3 micrometers, or less than 2 micrometers.", "In another aspect, a suspension is produced by wet milling a pharmaceutical active agent in an aqueous solution at less than 20° C. to form a milled pharmaceutical active agent; maintaining the milled pharmaceutical active agent at less than 5° C.; and lyophilizing the milled pharmaceutical active agent to form a lyophilized pharmaceutical active agent having a median particle size, as measured by laser diffraction, of less than 10 micrometers, such as less than 5 micrometers, less than 3 micrometers, or less than 2 micrometers.", "The composition may be gamma-irradiated to sterilize the composition.", "After storage for 150 days at 37° C., the weight average molecular weight of the lactic acid-based polymer of the gamma-irradiated composition is at least 90%, such as at least 95%, of the weight average molecular weight of the lactic acid-based polymer of an otherwise identical composition that is not gamma-irradiated before being stored for 150 days at 37° C. The weight average molecular weight of the lactic acid-based polymer of the composition after storage for 150 days at 37° C. is typically at least 50%, such as at least 60%, of the weight average molecular weight of the lactic acid-based polymer immediately before gamma radiation.", "Thus, in one aspect of the present disclosure a process of sterilizing a composition is provided, which process comprises gamma-irradiating a composition as defined elsewhere herein.", "In some cases, the composition is stored at room temperature (e.g., 25° C.).", "In other cases, the composition is stored at 5° C. In still other cases, the composition is stored at −20° C. Propylene carbonate improves the settling performance of compositions and allows longer shelf life and storage at refrigerated conditions of 2-8° C. when compared with compositions incorporating only NMP as the solvent.", "The results achieved with propylene carbonate are unexpected as the improvement is greater than would have been predicted from density considerations, as discussed in more detail below.", "Propylene carbonate suspensions typically exhibit improved, acceptable settling performance, partially because PC has higher density than NMP.", "The higher density vehicle is closer to the density of risperidone; therefore the property helps to prevent the drug from settling.", "Another reason is that risperidone has higher solubility in NMP than in PC.", "Recrystallization and crystal growth may occur faster in NMP containing compositions which results in increasing particle size and settling rate with time.", "Settling at low concentration of a spherical particle in a Newtonian fluid is described by the Stokes settling equation: v = 2  r 2  ( ρ 1 - ρ 2 )  g 9  η where: v=settling velocity r=particle radius ρ1 and ρ2=density of particle and fluid, respectively g=acceleration due to gravity η=viscosity of fluid For samples in a centrifuge, the acceleration due to gravity is replaced by the centripetal acceleration in the centrifuge: v = 2  r 2  ( ρ 1 - ρ 2 )  ω 2  R 9  η where: ω=angular velocity R=centrifuge radius The conditions for these equations are not strictly obeyed in the experiments described in this disclosure, but the equations can serve as a guide to expected behavior: Larger particles (larger r) are expected to settle more quickly.", "The larger the density difference between the particle and the fluid, the larger the expected settling velocity.", "Differences in settling velocity are expected to be proportional to overall differences in density.", "The lower the viscosity of the fluid, the more quickly the particles are expected to settle.", "The magnitude of the improvement in settling performance of propylene carbonate compositions was unexpectedly greater than would have been expected from theory.", "While not being bound by hypotheses, this unexpected result may reflect a slower rate of particle size growth during storage for the PC compositions.", "This does not appear to be due to the actual solubility of risperidone in the placebo vehicles, but might reflect the risperidone solubility in the respective solvents.", "The disclosed compositions may be administered to subjects using conventional routes of administration, such as injection.", "Effective amounts of biologically active substances may be incorporated into the disclosed compositions so as to achieve a desired pharmacological effect.", "In one aspect of the disclosure, a method of administering a pharmaceutical active agent such as, but not limited to, risperidone, paliperidone, or a combination thereof, comprises administering an effective amount of the composition.", "The composition typically comprises from 0.1 mg to 500 mg, such as 1 mg to 250 mg, 5 mg to 150 mg, or 25 mg to 150 mg, of the pharmaceutical active agent, such as risperidone or a pharmaceutically acceptable salt thereof.", "The composition may be administered on a regular basis, e.g., twice weekly or once a month.", "The composition is typically administered in an amount ranging from 0.05 mL to 10 mL, such as 0.1 mL to 8 mL, or 1 mL to 5 mL.", "In one aspect, the pharmaceutical active agent and any metabolites thereof have a plasma level in the patient of at least 1 ng/mL, such as at least 5 ng/mL, or at least 8 ng/mL, at 28 days after administration.", "For instance, 9-OH risperidone is an active metabolite of risperidone.", "In another aspect, the median Cmax of the pharmaceutical active agent ranges from 5 ng/mL to 300 ng/mL, such as 5 to 100 ng/mL, 10 ng/mL to 70 ng/mL, or even 100 ng/mL to 200 ng/mL.", "The median Cmax to Cmin ratio of the pharmaceutical active agent, as measured over 28 days, 21 days, or 14 days after administration, typically ranges from 2 to 40, such as from 5 to 30, or 10 to 20.An amount of pharmaceutical active agent delivered into plasma at 24 hours of subcutaneous administration typically ranges from 0.5% to 50%, such as 0.5% to 20%, 0.5% to 15%, 1% to 10%, 2% to 5%, or even 20% to 50%, of a total amount of the pharmaceutical active agent administered.", "An amount of pharmaceutical active agent delivered into plasma at 4 weeks of subcutaneous administration ranges from 20% to 100%, such as 20% to 75%, or 30% to 60%, of a total amount of the pharmaceutical active agent administered.", "An amount of pharmaceutical active agent delivered into plasma at 24 hours of subcutaneous administration divided by an amount of pharmaceutical active agent delivered at 4 weeks of administration ranges from 0.05 to 0.2, such as 0.05 to 0.15, or 0.08 to 0.12.The administering may be subcutaneous, intramuscular, parenteral, via a catheter, etc.", "The administration may be accomplished via a needle and syringe, pump, patch-pump, bolus injector, infusion, etc.", "In one aspect of the disclosure, a method of treating at least one of schizophrenia and bipolar disorder comprises administering an effective amount of a composition that contains a pharmaceutical active agent that is an anti-schizophrenia agent to a patient in need thereof.", "For instance, the anti-schizophrenia agent may comprise at least one of risperidone and paliperidone, or a pharmaceutically acceptable salt thereof.", "In one embodiment, the composition is contained in a needle-free injector.", "In one embodiment, the needle-free injector is Zogenix's DosePro® Needle-free injector.", "FIG.", "1 presents a longitudinal section through the DosePro® needle-free injector internal drug storage and delivery componentry.", "In FIG.", "1, the injection force is provided by a compressed gas spring, which comprises a cylinder 1 enclosed at one end, and containing a gas, typically nitrogen, typically at a pressure between 150 and 300 bar.", "Contained within the cylinder is a ram 2.The end of the ram has a frusto-conical, truncated cone—portion 3 and a flange 4.There is a double o-ring seal 5 situated between the truncated cone section 3 and the flange 4.Prior to triggering the device, the ram 2 is held in the position illustrated in FIG.", "1 by a latch 6 which sits in a groove in the dispensing member.", "The upper surface of the groove forms a cam surface 7.Consequently, there is force urging the latch to move to the left.", "In the configuration shown in FIG.", "1, the latch is restricted from moving by the outer ring 8.At the lower end of the cylinder 1, there is an outwardly directed flange 9.The cylinder is held in place by crimping the flange 9 to another outwardly directed flange 10 on the upper end on a coupling 11.The sleeve 8 consists of an upper sleeve portion 12 within which the cylinder is situated, and a lower sleeve portion 13.The lower sleeve portion 13 is connected to the coupling 11 by inter-engaging screw threads 14 formed on the inner and outer walls of the lower sleeve portion 13 and the coupling respectively 11.The injector has a cartridge 15 which contains the medicament.", "In the cartridge there is a piston 16, slidingly and sealingly located therein.", "The piston 16 may comprise a cylindrical portion containing two larger diameter ribs, and a frusto-conical portion.", "The piston 16 is in contact with the medicament 17 and at the other end of the cartridge 15 there is a discharge orifice 18.Adjacent to the orifice 18 there is an interface seal 19 contained within a seal carrier 20.The interface seal 19 is required for filling the needle-free device as described in PCT/GB9700889.A stopper 20a seals the medicament into the capsule.", "Seal 19, seal carrier 20, and stopper 20a, comprise the cap that must be removed prior to delivery.", "To place the device in the ready to deliver state, the cap must be snapped off at the frangible joint 21.This removes the seal 19 and exposes the orifice 18.The trigger blocking mechanism 22, which prevents the medication cartridge from moving back toward the upper sleeve portion 22, thereby preventing delivery, is removed.", "Finally, latch 6 must be moved from the first (safe) position, to the second (ready to deliver) position.", "The latch 6 is incorporated into a groove in the dispensing member 2—not only does the groove have a cam surface 7 but also a locking surface 27 which is perpendicular to the dispensing member axis and is located radially inward of the cam surface 7.Additionally, to access the latch 6 there is an opening 28 in the upper sleeve 12, which prior to triggering is aligned with the latch 6.FIGS.", "2a, b and c illustrate the operation of the safety mechanism.", "When the latch and dispensing member are initially assembled, the latch occupies the first (safe) position, as shown in FIG.", "2a.", "In this position, the dispensing member-engaging latch portion 29 is acted on by the locking surface 27.Frictional force ensures that the latch is held rigid by the locking surface—typically the dispensing member exerts a force of at least 100N.", "The latch is placed in the second (ready to deliver) position using a pin which fits through opening 28 to push the latch in the direction of the arrow P into the position shown in FIG.", "2b, (and in FIG.", "1).", "In this position the dispensing member engaging latch portion 29 is in contact with the radially inner end of the cam surface 7.To cause delivery, the orifice 18 is then placed against the skin of the patient.", "Practically, this involves holding the device by the upper sleeve 12 portion.", "The upper sleeve 12 is then moved downwards with respect to the lower sleeve 13, bringing aperture 25 in the wall of the upper sleeve portion 8 into alignment with the latch 6.The latch then moves to the left into the aperture 25, under the force exerted on it by the cam surface 7 formed in the dispensing member 3 into the position shown in FIG.", "2c.", "The injector then delivers.", "It is advantageous to have a mechanism that places the device in the ready to deliver state in a simple motion or motions.", "FIG.", "3 illustrates one embodiment of the combined needle-free injector plus means for disengaging the safety mechanism 30.In this Figure, the means for disengaging the safety mechanism consists of a cap 31 enclosing, and holding rigidly, the seal carrier 20, a lever 32 and a collar 33.The lever contains a lip 34 at the far end, over which the cap 31 is positioned.", "This ensures that the lever 32 cannot be moved before the outer cap 31 is removed, which in turn ensures that the user cannot move the latch or disengage the safety mechanism until the cap has been removed.", "The lever 32 is pivoted around the pivot axis 35, with the pivoted surface in contact with injector being a cam surface 36.The force required to pivot lever 32 is in the range from about 2N to about 30N.", "The collar 33 contains a pin 37 which extends into the device through the opening 28 in the upper sleeve 12 to impinge on the far side of the latch 6.The force required to move the latch is in the range from about 20N to about 120N.", "To stop the upper sleeve section 12 moving with respect to the lower sleeve section 13, there are block sections 38 between the upper and lower sleeves, which form part of the collar 33.To deliver the device contents, the cap 31 is removed, exposing the injection orifice 18.With the outer cap 31 removed, the lip 34 is exposed, enabling the lever 32 to rotate about the pivot axis 35.Only when the outer cap 31 is removed can the lever 32 be rotated.", "As the lever 32 rotates, the cam surface 36 forces the collar 33 to move in the direction Q in FIG.", "3, pushing the pin 37 against the latch 6.When the lever 32 has rotated through a complete cycle, approximately 180 degrees, the latch 6 moves to the second position, as shown in FIG.", "2b.", "The blocks 38 no longer restrict the movement of the upper sleeve 12 with respect to the lower sleeve 13 and the device can trigger as described above.", "By integrating the cap 31 to the lever 32 with a flexible joint at the tip 34, the mechanism can also be configured to ensure that the user removes the stopper and sets the safety in a single action.", "In one aspect, a needle-free injector comprises a composition comprising a pharmaceutical active agent.", "The needle-free injector may further comprise a drug capsule.", "The drug capsule may be transparent or partly transparent.", "The drug capsule may be closed at one end by a piston.", "The piston may comprise a polymer, such as a clear polymer and such as polytetrafluoroethylene.", "Alternatively, the drug capsule may comprise glass, such as borosilicate glass.", "The glass may have undergone ion exchange strengthening.", "In some cases, the transparent portion of the drug capsule does not change color when gamma-irradiated.", "In some cases, the drug capsule is prefilled.", "The needle-free injector may be single use and disposable.", "The drug capsule may comprise at least one injection orifice.", "The at least one injection orifice may be closed during storage by a sealing element.", "The sealing element may be held rigidly to the injection orifice by a seal carrier.", "In some cases, the seal carrier must be removed prior to use.", "The seal carrier may be connected to the drug capsule by at least one element selected from: a frangible connection, a screw connection, a bayonet connection, and a luer connection.", "The needle-free injector may comprise a triggering mechanism.", "The triggering mechanism may be activated by pressing the at least one injection orifice against the target injection surface.", "The needle-free injector may further comprise a safety mechanism that ensures that the device cannot be actuated prematurely.", "The safety mechanism ensures that the device cannot be actuated until after removal of the seal carrier.", "The needle-free injector may comprise a self-contained energy source.", "The energy source comprises at least one member selected from: a compressed mechanical spring, a compressed gas, a pyrotechnic charge, and a battery.", "The needle-free injector may further comprise a ram which upon activation of the triggering mechanism, under the urging of the energy source traverses a gap and subsequently strikes the piston, creating a pressure spike in the composition.", "The urging of the energy source, the mass of the ram, the length of the gap, the mechanical properties of the piston, and the size of the orifice may be selected such that in use, more than 90% of injections inject more than 90% of the composition subcutaneously.", "In one exemplary embodiment, the composition is delivered using a needle-free injector.", "Needle-free injectors are representative examples for the delivery of antipsychotic active pharmaceutical ingredients for a number of reasons.", "Psychotic patients may present for treatment in a highly agitated state, and the sight of a needle, or the puncture of the skin by a needle, may significantly increase this agitation.", "The psychotic state and agitation may increase the likelihood of the patient moving erratically during administration of the composition, increasing the risk of injury to the patient, and also increasing the risk of injury and exposure of the care giver to pathogens.", "Needle-free injectors remove the requirements of sharps disposal, further simplifying administration procedures and making them safer.", "In one aspect, the present disclosure comprises a unit dosage form that may be prefilled, sterile, compatible with gamma sterilization, single use disposable, an auto-injector, may include a safety mechanism to prevent premature actuation, may include additional safety features to prevent or reduce the incidence to needle stick injury, including but not limited to needle shields, needle retraction and needle-free injection, may be portable and include a self contained power source, and may be disabled after use.", "An exemplary embodiment of the needle-free injector is prefilled, and portable with a self contained energy source.", "This embodiment further simplifies the administration, and allows a skilled care giver to give more attention to the patient and spend less time preparing the injection.", "This embodiment, and the removal of the requirement for sharps disposal, may also enable administration in a home or residential or long term care facility setting by a skilled care giver, family member, or the self administration by the patient.", "For example, the preparation of and delivery from a needle-free injector would require less than 10 steps, such as less than 5 steps, and further such as 3 steps or fewer.", "For example, one embodiment requires only three steps: The removal of an orifice cap, actuation of a safety mechanism actuator to place the device in the ready to deliver state, and pressing the orifice against the desired injection site to trigger.", "It may also be possible to combine the actions of removal of an orifice cap and actuation of the safety mechanism, further simplifying delivery.", "Needle-free injectors can be used, for example, for the delivery of elevated viscosity compositions, including those of the current disclosure.", "Delivery of high viscosity compositions by needle and syringe can be difficult due to high required hand strength and long delivery times.", "These problems often lead to the requirement for delivery via infusion or bolus injectors.", "The long delivery times via needle and syringe or infusion can be especially problematic for the treatment of psychotic patients, who may present in an agitated state.", "Needle-free injection can significantly reduce delivery time, as the ratio of delivery orifice length to lumen diameter, which is very small compared to needle systems such as syringes or infusion systems, generally reduces or avoids the development of viscous flow during delivery, allowing the delivery of viscous compositions in short times.", "This feature in combination with a self contained energy source removes the requirement of high hand strength.", "The advantages of needle-free injection for high viscosity compositions are described in U.S. Pat.", "No.", "8,066,661.The combination of a sufficiently powerful source of energy and low viscous losses in a needle-free injector leads to very short delivery times, in general less than 0.5 seconds, such as less than 0.2 seconds, and further such as about 0.1 seconds or less.", "These short delivery times are less than human reaction times, and significantly reduce the possibility of the patient moving during administration, further improving safety to the patient and caregiver.", "Compliance with prescribed treatment is an issue with all treatment regimens, and can be particularly problematic in the treatment of psychotic patients.", "Combinations of features of a delivery system, and particularly needle-free injectors such as prefilled, single use, disposable, requiring a minimized number of steps for preparation and delivery, portability, a self contained power source, no requirement for sharps disposal, removal of risk of needle stick injury, short delivery times, low hand strength requirements, ability for administration in a home or care facility, ability for self administration, avoidance of premature actuation, and removal of fear and agitation caused by needles.", "Those features, alone or in combination, can work to increase compliance.", "Needle-free injectors are available using many different types of energy, and the energy may be supplied by the user, for example where a spring is manually compressed and latched to temporarily store the energy until it is required to “fire” the injector.", "Alternatively, the injector may be supplied having the energy already stored—for instance by means of a precompressed spring (mechanical or gas), or pyrotechnic charge.", "Some injectors are intended for disposal after a single use, whereas others have a re-loadable energy storage means and a disposable medicament cartridge, and there are many combinations to suit particular applications and markets.", "For the purposes of the present disclosure, the term “actuator” will be used to describe the energy storage and release mechanism, whether or not it is combined with the medicament cartridge.", "In all cases, it is necessary to arrange for sufficient force at the end of the piston stroke to deliver the entire medicament at the required pressure.", "EP 0 063 341 and EP 0 063 342 disclose a needle-free injector which includes a piston pump for expelling the liquid to be injected, which is driven by a motor by means of a pressure agent.", "The liquid container is mounted laterally to the piston pump.", "The amount of liquid required for an injection is sucked into the pump chamber by way of an inlet passage and a flap check valve when the piston is retracted.", "As soon as the piston is moved in the direction of the nozzle body the liquid is urged through the outlet passage to the nozzle and expelled.", "The piston of the piston pump is a solid round piston.", "EP 0 133 471 describes a needle-free vaccination unit which is operated with carbon dioxide under pressure, from a siphon cartridge by way of a special valve.", "EP 0 347 190 discloses a vacuum compressed gas injector in which the depth of penetration of the injected drug can be adjusted by means of the gas pressure and the volume of the drug can be adjusted by way of the piston stroke.", "EP 0 427 457 discloses a needle-free hypodermic syringe which is operated by means of compressed gas by way of a two-stage valve.", "The injection agent is disposed in an ampoule which is fitted into a protective casing secured to the injector housing.", "The ampoule is fitted on—to the end of the piston rod.", "Disposed at the other end of the ampoule is the nozzle whose diameter decreases towards the end of the ampoule.", "WO 89/08469 discloses a needle-free injector for one-off use.", "WO 92/08508 sets forth a needle-free injector which is designed for three injections.", "The ampoule containing the drug is screwed into one end of the drive unit, with the piston rod being fitted into the open end of the ampoule.", "At its one end, the ampoule contains the nozzle through which the drug is expelled.", "A displaceable closure plug is provided approximately at the center of the length of the ampoule.", "The dose to be injected can be adjusted by changing the depth of the ampoule.", "The piston rod which projects from the drive unit after actuation of the injector is pushed back by hand.", "Both units are operated with compressed gas.", "WO 93/03779 discloses a needle-free injector with a two-part housing and a liquid container which is fitted laterally to the unit.", "The drive spring for the piston is stressed by means of a drive motor.", "The spring is released as soon as the two parts of the housing are displaced relative to each other by pressing the nozzle against the injection location.", "Respective valves are provided in the intake passage for the liquid and in the outlet of the metering chamber.", "WO 95/03844 discloses a further needle-free injector.", "It includes a liquid-filled cartridge which at one end includes a nozzle through which the liquid is expelled.", "At the other end the cartridge is closed by a cap-type piston which can be pushed into the cartridge.", "A piston which is loaded by a pre-stressed spring, after release of the spring, displaces the cap-type piston into the cartridge by a predetermined distance, with the amount of liquid to be injected being expelled in that case.", "The spring is triggered as soon as the nozzle is pressed sufficiently firmly against the injection location.", "This injector is intended for one-off or repeated use.", "The cartridge is arranged in front of the spring-loaded piston and is a fixed component of the injector.", "The position of the piston of the injector which is intended for a plurality of uses is displaced after each use by a distance in a direction towards the nozzle.", "The piston and the drive spring cannot be reset.", "The pre stressing of the spring is initially sufficiently great to expel the entire amount of liquid in the cartridge all at once.", "The spring can only be stressed again if the injector is dismantled and the drive portion of the injector assembled with a fresh, completely filled cartridge.", "U.S. Pat.", "No.", "5,891,086 describes a needle-free injector, combining an actuator and a medicament cartridge.", "The cartridge is pre-filled with a liquid to be injected in a subject, and having a liquid outlet and a free piston in contact with the liquid, the actuator comprising an impact member urged by a spring and temporarily restrained by a latch means, the impact member being movable in a first direction under the force of the spring to first strike the free piston and then to continue to move the piston in the first direction to expel a dose of liquid through the liquid outlet, the spring providing a built-in energy store and being adapted to move from a higher energy state to a lower energy state, but not vice versa.", "The actuator may comprise trigger means to operate the said latch, and thus initiate the injection, only when a predetermined contact force is achieved between the liquid outlet of the said cartridge and the subject.", "Further examples and improvements to this needle-free injector are found in U.S. Pat.", "No.", "6,620,135, U.S. Pat.", "No.", "6,554,818, U.S. Pat.", "No.", "6,415,631, U.S. Pat.", "No.", "6,409,032, U.S. Pat.", "No.", "6,280,410, U.S. Pat.", "No.", "6,258,059, U.S. Pat.", "No.", "6,251,091, U.S. Pat.", "No.", "6,216,493, U.S. Pat.", "No.", "6,179,583, U.S. Pat.", "No.", "6,174,304, U.S. Pat.", "No.", "6,149,625, U.S. Pat.", "No.", "6,135,979, U.S. Pat.", "No.", "5,957,886, U.S. Pat.", "No.", "5,891,086, and U.S. Pat.", "No.", "5,480,381.U.S.", "Pat.", "No.", "3,859,996, Mizzy, discloses a controlled leak method to ensure that the injector orifice is placed correctly at the required pressure on the subject's skin at the correct normal to the skin attitude.", "When placement conditions are met, controlled leak is sealed off by contact pressure on the subject's skin, the pressure within the injector control circuit rises until a pressure sensitive pilot valve opens to admit high pressure gas to drive the piston and inject the medicament.", "WO Patent 82/02835, Cohen and Ep-A-347190, Finger, discloses a method to improve the seal between the orifice and the skin and prevent relative movement between each.", "This method is to employ a vacuum device to suck the epidermis directly and firmly onto the discharge orifice.", "The discharge orifice is positioned normal to the skin surface in order to suck the epidermis into the orifice.", "This method for injection of the medicament into the skin and the injector mechanism are different and do not apply to the present disclosure because of its unique ampule design.", "U.S. Pat.", "No.", "3,859,996, Mizzy, discloses a pressure sensitive sleeve on the injector which is placed on the subject, whereby operation of the injector is prevented from operating until the correct contact pressure between orifice and the skin is achieved.", "The basic aim is to stretch the epidermis over the discharge orifice and apply the pressurized medicament at a rate which is higher than the epidermis will deform away from the orifice.", "U.S. Pat.", "No.", "5,480,381, T. Weston, discloses a means of pressuring the medicament at a sufficiently high rate to pierce the epidermis before it has time to deform away from the orifice.", "In addition, the device directly senses that the pressure of the discharge orifice on the subject's epidermis is at a predetermined value to permit operation of the injector.", "The device is based on a cam and cam follower mechanism for mechanical sequencing, and contains a chamber provided with a liquid outlet for expelling the liquid, and an impact member, to dispell the liquid.", "U.S. Pat.", "No.", "5,891,086, T. Weston, describes a needle-free injector embodiment that contains a chamber that is pre-filled with a pressurized gas which exerts a constant force on an impact member in order to strike components of a cartridge and expulse a dose of medicament.", "This device contains an adjustment knob which sets the dose and the impact gap, and uses direct contact pressure sensing to initiate the injection.", "In an exemplary embodiment of the disclosure for the delivery of sustained release risperidone and other active pharmaceutical ingredients, the composition may be delivered using a needle-free injector which is single use, disposable, portable, and has a self contained energy source comprising compressed nitrogen gas.", "The composition is factory prefilled in a borosilicate glass capsule which is strengthened by ion exchange.", "The glass capsule is sealed at the proximal end by a piston which is comprised of polytetrafluoroethylene which has been modified to improve its sealing properties.", "The glass capsule comprises an injection orifice at the distal end which is sealed after filling and during storage by a seal which is held in a seal carrier.", "The glass capsule is contained in a clear plastic sleeve which is frangibly attached to the seal carrier.", "The injector comprises a ram which comprises a pair of o-rings that seal the compress gas chamber of the energy source.", "Before actuation the ram is held in place against the urging of the compressed gas by a latch.", "The latch has a safe position, a ready position and a triggered position.", "The latch is disposed in a slot in the ram which has a latch safe section which is perpendicular to the ram axis, and a latch ready section at a slope to the ram axis and functions as a cam.", "The ram is separated from the piston by a gap, across which upon triggering the ram flies under the urging of the compressed gas, striking the piston.", "The injector comprised a safety lever, which when rotated moves the latch from the safe to the ready position and removes an additional blocking element.", "The level and the seal carrier are configured to ensure that the seal carrier must be removed prior to actuating the latch.", "The injector is partially contained in a housing.", "The housing comprises an aperture into which the latch moves under the urging of the cam surface when the device is actuated.", "The housing, after removal of the blocking element, is slidable relative to the internal components.", "Disposed between the housing and the internal components is a damping grease which prevents recoil of the internal components when the injector is actuated.", "To deliver the contents of the injector, first the seal carrier and seal is removed.", "Then the lever is actuated.", "The orifice is pressed against the desired injector site.", "This pressing causes the housing to slide relative to the internal components, exposing the latch to the aperture.", "The latch moves into the aperture under the urging of the cam, freeing the ram and triggering the device.", "Upon striking the piston, the ram creates a pressure spike in the composition.", "This portion of the delivery is the puncture phase, whereby composition leaving the capsule through the orifice creates a hole in the skin down to the subcutaneous layer.", "The ram then causes piston, under the urging of the compressed gas, to move through the capsule, expelling the remainder of the composition in a reduced pressure delivery phase.", "This embodiment, improvements to this embodiment, methods of manufacture, and methods of treatment are described in U.S. Pat.", "Nos.", "5,891,086; 5,957,886; 6,135,979; 7,776.007; 7,901,385; 8,267,903; 8,118,771; 8,241,243; 8,241,244; 8,287,489; 8,343,130; 7,150,297; 6,251,091; 6,174,304; 6,681,810; 6,280,410; 6,554,818; 6,620,135; 5,480,381; 7,231,945; 7,320,346; and 8,066,661; and PCT applications PCT/US2012/020654; PCT/US2011/051617, PCT/US2009/002533; and PCT/US2007/001403.The current disclosure describes various viscous compositions that can be delivered using a needle-free injector including the injector of U.S. Pat.", "No.", "5,891,086 to provide for subcutaneous (SC), intradermal (ID), intramuscular (IM) and other types of delivery.", "In some cases, the compositions are phase stable and/or require relatively low amounts of solvent.", "While not wishing to be bound by theory, this result may achieved by one or more of relatively low molecular weight polymer, relatively high L:G ratio, and polymers having alkoxy end groups.", "Compositions with reduced solvent are typically beneficial as they are generally more biocompatible.", "Studies conducted with the clinical composition described in Example 14 comprising risperidone, along with other compositions of similar chemical composition, indicate that the PK profile of SC risperidone-vehicle composition is consistently characterized by a sustained release of risperidone with low initial burst/no dose dump, a gradual decline in risperidone levels over time, and dose proportionality.", "Initial burst is a common phenomenon to most types of depot compositions and needs to be low enough such that the maximum observed concentration (Cmax) and the maximum exposure levels (i.e., area under the concentration-time curve [AUC] from time zero to 24 hours [AUC0-24 hr] and maximum observed concentration [Cmax]), do not exceed thresholds which result in adverse events.", "The compositions may be administered SC as a once monthly administration and may lead to improved patient compliance over short-acting oral tablets or biweekly IM administration.", "Risperidone compositions may not require oral dose supplementation because drug release begins immediately upon injection, leading to a less complicated initiation of product dosing and improved patient compliance.", "The present disclosure will be further illustrated by way of the following Examples.", "These examples are non-limiting and do not restrict the scope of the disclosure.", "Unless stated otherwise, all percentages, parts, etc.", "presented in the examples are by weight.", "EXAMPLES Example 1: Polymer Synthesis This Example involves a representative polymer synthesis.", "DL-lactide (147.22 grams), glycolide (39.52 grams), and 1-dodecanol (13.25 grams) were added to a 500-mL, 3-neck round bottom flask.", "The flask was sealed with a glass stopper, a gas joint with a stopcock, and a stirrer bearing with a glass shaft and Teflon® paddle.", "The ambient atmosphere was removed from the flask under vacuum and the flask was back-filled with nitrogen gas.", "The flask was placed in an oil batch at 155° C. and stirred under a positive pressure of nitrogen gas.", "When the monomer and initiator had melted, stannous 2-ethylhexanoate was added as a solution in dry toluene.", "The amount of catalyst added was approximately 0.016 wt %.", "The polymerization was allowed to proceed for 3 hours.", "Next, the solid polymer was subjected to vacuum to remove residual monomer for one hour.", "Then the contents of the flask were discharged from the flask onto a sheet of Teflon® film and allowed to cool.", "Once cooled, the product was crushed to granular powder in a stainless steel beaker and with a stainless steel pestle.", "The resulting polymer had a weight average molecular weight (Mw) (measured by GPC in tetrahydrofuran) of 7.7 kDa.", "Example 2: Vehicle Formulations This Example involves a representative method of making a formulation comprising sucrose acetate isobutyrate, polymer, and solvent.", "Poly(lactic acid)(glycolic acid) (PLGA) was removed from cold storage and allowed to warm to room temperature.", "The polymer was weighed in a glass jar.", "Next, N-methyl-pyrrolidone (NMP) was dispensed into the glass jar.", "To dissolve the PLGA in the NMP, the mixture was placed in a rotator and rotated at 20 rpm at room temperature for about 12 hours.", "Sucrose acetate isobutyrate (SAIB) was heated to 80° C. for approximately an hour.", "The heated SAIB was poured into the glass jar containing the PLGA and NMP.", "The mixture was rotated in an oven at 50° C. at 20 rpm for about 2 hours.", "The jar was removed from the oven and allowed to cool to room temperature.", "Example 3: Effect of Polymer End Group Phase compatibility studies were performed to generate a thermodynamic understanding of the formulation variables and to inform formulation design.", "One of the studies involved evaluation of the role of polymer end groups and their impact on phase stability.", "Several formulations were made to evaluate the phase stability of formulations including various proportions of sucrose acetate isobutyrate, N-methyl-pyrrolidone, and poly(lactic acid)(glycolic acid).", "The poly(lactic acid)(glycolic add) was either initiated with dodecanol to yield a polymer with a dodeoxy end group or initiated with 1-hexanediol to yield a polymer with alcohol end groups.", "The solubilization of these formulations was observed visually.", "The results are summarized in the ternary phase diagrams depicted in FIGS.", "4 to 6.FIGS.", "4 and 5 are phase diagrams for formulations including the polymer initiated with 1-hexanediol.", "Specifically, open circles indicate formulations that were monophasic, whereas solid circles indicate formulations that phase separated.", "Information on the meaning of the crosses in FIG.", "4 was not readily available.", "FIG.", "6 is a phase diagram for formulations including the polymer initiated with dodecanol.", "Comparing FIGS.", "4 to 6 shows that the formulations including the polymer initiated dodecanol provided a larger region of solubility than formulations including the polymer initiated with 1-hexanediol.", "Thus, the polymer with a dodeoxy end group provided a broader region of thermodynamically stable, mono-phase compositions.", "Example 4: Vehicle Formulations Further vehicle examples were prepared.", "Information relating to these examples is set forth in Table 1.Vehicle Nos.", "1-7 are taken from U.S.", "Published Application No.", "2008/0287464.For purposes of clarity, not all examples from the '464 application are included in the below Table 1.Table 1 includes the following abbreviations: SAIB: sucrose acetate isobutyrate NMP: N-methyl-pyrrolidone DMSO: dimethylsulfoxide CremophorEL: Cremophor EL Pluronic L44: Pluronic L44 BB: benzyl benzoate PC: propylene carbonate DMA: dimethylacetamide Solutol: Solutol® HS 15 polyoxyethylene esters of 12-hydroxystearic acid PLGA: poly(lactic acid)(glycolic acid) PLA: poly(lactic acid) PLA R202H: Resomer 202H poly(lactic acid) TerCGL: poly(caprolactone)(glycolic acid)(lactic acid) H2O: water HD: 1-hexanediol DD: dodecanol LA: lactic acid L:G: molar ratio of lactic acid to glycolic acid L:G:C: molar ratio of lactic acid to glycolic acid to caprolactone C8: octanol C16: 1-hexadecanol TABLE 1 PLGA or PLA or TerCGL Vehicle L:G or Mw Solubility No.", "Vehicle Initiator L:G:C (kDa) Behavior 1 SAIB/NMP/PLGA HD 65:35 5.3 Not soluble (65/20/15) 2 SAIB/NMP/PLGA HD 65:35 5.3 Not soluble (60/20/20) 3 SAIB/NMP/DMSO/PLGA HD 65:35 5.3 Separates long (53.8/15.4/10.8/20.1) term 4 SAIB/NMP/DMSO/PLGA HD 65:35 5.3 Separates long (54.9/15.0/9.8/20.1) term 5 SAIB/NMP/DMSO/PLGA HD 65:35 5.3 Separates long (55/20/5/20) term 6 SAIB/NMP/BB/PLGA HD 65:35 5.3 Not soluble (55/20/5/20) 7 SAIB/NMP/PLGA H2O 50:50 5.3 Separates at RT (70/25/5) & 37° C. 8 SAIB/NMP/PLGA DD 65:35 6.3 Monophasic (55/25/20) 9 SAIB/NMP/PLGA DD 65:35 6.5 Monophasic (45/25/30) 10 SAIB/NMP/PLGA DD 65:35 6.5 Monophasic (60/20/20) 11 SAIB/NMP/PLGA DD 65:35 6.5 Monophasic (55/20/25) 12 SAIB/NMP/DMSO/PLGA DD 65:35 6.5 Monophasic (55/20/5/20) 13 SAIB/NMP/DMSO/PLGA DD 65:35 6.5 Monophasic (55/15/10/20) 14 SAIB/NMP/DMSO/PLGA DD 65:35 6.5 Monophasic (55/10/10/25) 15 SAIB/NMP/DMSO/PLGA DD 65:35 6.5 Monophasic (55/15/5/25) 16 SAIB/NMP/PLGA DD 65:35 6.5 Hazy (63.4/16.5/20) 17 SAIB/NMP/PLGA DD 65:35 6.5 Monophasic (62/18/20) 18 SAIB/NMP/PLGA DD 65:35 6.5 Turbid (64.2/15.8/20.0) 19 SAIB/NMP/CremophorEL/PLGA DD 65:35 6.5 Monophasic (52.4/20.6/10.3/16.7) 20 SAIB/Ethyl acetate/PLGA DD 65:35 6.5 Monophasic (54.7/24.7/21.1) (Hazy at 5° C.) 21 SAIB/NMP/PLGA/Pluronic L44 DD 65:35 6.5 Monophasic (46.1/16.7/16.7/20.4) 22 SAIB/NMP/PLGA DD 75:25 6.5 Monophasic (55/25/20) 23 SAIB/NMP/DMSO/PLGA DD 65:35 6.5 Monophasic (55/15/7/23) SAIB/BB/PLGA DD 65:35 6.5 Turbid (55/25/20) 24 SAIB/BB/TerCGL DD 23:25:52 17 Monophasic (55/25/20) 25 SAIB/BB/TerCGL DD 20:31:49 30.9 Turbid (55/25/20) 26 SAIB/NMP/TerCGL DD 23:25:52 17 Monophasic (55/25/20) 27 SAIB/NMP/TerCGL DD 20:31:49 30.9 Monophasic (55/25/20) 28 SAIB/PC/PLGA DD 65:35 6.5 Monophasic (55/25/20) 29 SAIB/NMP/BB/PLGA DD 65:35 6.5 Monophasic (45/15/20/20) 30 SAIB/PC/PLGA DD 65:35 6.5 Monophasic (50/30/20) 31 SAIB/NMP/PLGA DD 65:35 6.5 Monophasic (50/30/20) 32 SAIB/NMP/PLGA DD 65:35 6.5 Turbid (65/15/20) 33 SAIB/NMP/PLA R202H LA 100:0 14 Monophasic (55/25/20) 34 SAIB/NMP/PLGA DD 65:35 6.3 Monophasic (30/30/40) 35 SAIB/NMP/PLGA DD 75:25 6.5 Monophasic (55/25/20) 36 SAIB/NMP/PLGA/PLA R202H DD 75:25 6.5 Monophasic (55/25/17.5/2.5) LA 100:0 14 37 SAIB/NMP/PLGA DD 75:25 14.2 Monophasic (55/25/20) 38 SAIB/NMP/PLGA DD 85:15 7.7 Monophasic (55/25/20) 39 SAIB/NMP/PLGA DD 85:15 13.9 Monophasic (55/25/20) 40 SAIB/NMP/PLGA/PLA R202H DD 75:25 6.5 Monophasic (55/25/15/5) LA 100:0 14 41 SAIB/NMP/PLGA/PLA R202H DD 75:25 6.5 Monophasic (55/25/10/10) LA 100:0 14 42 SAIB/PC/PLGA DD 65:35 6.5 Monophasic (44.1/36.3/19.6) 43 SAIB/NMP/PLGA DD 75:25 6.9 Monophasic (55/25/20) 44 SAIB/NMP/PLGA DD 90:10 6.6 Monophasic (55/25/20) 45 SAIB/NMP/PLGA/PLA R202H DD 85:15 7.7 Monophasic (55/25/17.5/2.5) LA 100:0 14 46 SAIB/NMP/PLGA/PLA R202H DD 85:15 7.7 Monophasic (55/25/15/5.0) LA 100:0 14 47 SAIB/NMP/PLGA DD 75:25 6.9 Monophasic (60/25/15) 48 SAIB/NMP/PLGA DD 75:25 6.9 Monophasic (52.5/27.5/20) 49 SAIB/NMP/DMSO/PLGA DD 75:25 5.9 Monophasic (50/20/10/20) 50 SAIB/NMP/DMSO/PLGA DD 75:25 5.9 Monophasic (50/25/5/20) 51 SAIB/NMP/DMSO/PLGA DD 75:25 5.9 Monophasic (52/19/9/20) 52 SAIB/NMP/DMSO/PLGA DD 75:25 5.9 Monophasic (48/21/11/20) 53 SAIB/BB/PLA LA 100:0 15 Monophasic (8/72/20) 54 SAIB/NMP/PLGA DD 75:25 8.6 Monophasic (55/25/20) 55 SAIB/NMP/PLGA DD 75:25 6.9 Monophasic (50/30/20) 56 SAIB/NMP/PLGA DD 75:25 6.9 Monophasic (52/28/20) 57 SAIB/NMP/PLGA DD 75:25 6.9 Monophasic (55/26/20) 58 SAIB/NMP/PLGA DD 75:25 6.9 Monophasic (48/32/20) 59 SAIB/NMP/PLGA DD 75:25 6.9 Monophasic (49/31/20) 60 SAIB/NMP/PLGA DD 75:25 6.9 Monophasic (49.5/30.5/20) 61 SAIB/NMP/PLGA DD 75:25 6.9 Monophasic (51/29/20) 62 SAIB/NMP/PLGA DD 75:25 6.9 Monophasic (50.5/29.5/20) 63 SAIB/NMP/DMSO/PLGA DD 75:25 6.9 Monophasic (50/25/5/20) 64 SAIB/NMP/DMSO/PLGA DD 75:25 6.9 Monophasic (52/19/9/20) 65 SAIB/NMP/DMSO/PLGA DD 75:25 6.9 Monophasic (50/20/10/20) 66 SAIB/NMP/DMSO/PLGA DD 75:25 6.9 Monophasic (48/21/11/20) 67 SAIB/NMP/PLGA DD 75:25 7.0 Monophasic (55/25/20) 68 SAIB/NMP/PLGA DD 75:25 7.0 Monophasic (50/30/20) 69 SAIB/NMP/PLGA DD 75:25 6.9 Monophasic (46/34/20) 70 SAIB/NMP/DMSO/PLGA DD 75:25 6.9 Monophasic (46/22.5/11.5/20) 71 SAIB/NMP/PLGA DD 75:25 7.0 Monophasic (46/34/20) 72 SAIB/NMP/DMSO/PLGA DD 75:25 7.0 Monophasic (46/22.5/11.5/20) 73 SAIB/NMP/DMSO/PLGA DD 75:25 7.0 Monophasic (48/21/11/20) 74 SAIB/NMP/PLGA DD 75:25 7.0 Monophasic (51.5/30/18.5) 75 SAIB/NMP/PLGA DD 75:25 7.0 Monophasic (52/29/19) 76 SAIB/NMP/PLGA DD 75:25 7.0 Monophasic (53.5/27/19.5) 77 SAIB/NMP/DMSO/PLGA DD 75:25 7.0 Monophasic (50/20/10/20) 78 SAIB/PC/PLGA DD 75:25 7.0 Monophasic (44/36.5/19.5) 79 SAIB/NMP/PLGA DD 75:25 7.0 Monophasic (45/35/20) 80 SAIB/NMP/PLGA DD 75:25 7.0 Monophasic (44/36/20) 81 SAIB/NMP/PLGA DD 75:25 7.0 Monophasic (40/40/20) 82 SAIB/NMP/PLGA DD 75:25 7.0 Monophasic (31/49/20) 83 SAIB/NMP/PLGA DD 75:25 7.0 Monophasic (58/27/15) 84 SAIB/NMP/PLGA DD 75:25 7.0 Monophasic (55/28/17) 85 SAIB/PC/PLGA DD 75:25 7.0 Monophasic (44/37/19) 86 SAIB/NMP/DMSO/PLGA DD 75:25 7.0 Monophasic (52/15/14/19) 87 SAIB/DMSO/PLGA DD 75:25 7.0 Monophasic (45/35/20) 88 SAIB/NMP/DMSO/PLGA DD 75:25 7.0 Monophasic (50/15.5/14.5/20) 89 SAIB/NMP/DMSO/PLGA DD 75:25 7.0 Monophasic (49.5/10/20.5/20) 90 SAIB/DMSO/PLGA DD 75:25 7.0 Monophasic (48/32/20) 91 SAIB/PC/PLGA DD 75:25 7.0 Monophasic (38/42/20) 92 SAIB/PC/PLGA DD 75:25 7.0 Monophasic (34/46/20) 93 SAIB/PC/PLGA DD 75:25 7.0 Monophasic (28/52/20) 94 SAIB/DMA/PLGA DD 75:25 7.0 Monophasic (50/30/20) 95 SAIB/NMP/PC/PLGA DD 75:25 7.0 Monophasic (46/10/24/20) 96 SAIB/NMP/PC/PLGA DD 75:25 7.0 Monophasic (48/20/12/20) 97 SAIB/DMA/PLGA DD 75:25 7.0 Monophasic (56/24/20) 98 SAIB/DMA/PLGA DD 75:25 7.0 Monophasic (55/25/20) 99 SAIB/DMA/PLGA DD 75:25 7.0 Monophasic (54/26/20) 100 SAIB/NMP/Miglyol/PLGA DD 75:25 7.0 Monophasic (49.5/29.5/1/20) 101 SAIB/NMP/Miglyol/PLGA DD 75:25 7.0 Monophasic (47/28/5/20) 102 SAIB/NMP/Miglyol/PLGA DD 75:25 7.0 Monophasic (44/26/10/20) 103 SAIB/NMP/Solutol/PLGA DD 75:25 7.0 Monophasic (50/27/3/20) 104 SAIB/NMP/Solutol/PLGA DD 75:25 7.0 Monophasic (50/24/6/20) 105 SAIB/NMP/Solutol/PLGA DD 75:25 7.0 Monophasic (48/29/3/20) 106 SAIB/NMP/Solutol/PLGA DD 75:25 7.0 Monophasic (46/28/6/20) 107 SAIB/NMP/PLGA DD 75:25 7.0 Monophasic (53/28/19) 108 SAIB/NMP/PLGA DD 75:25 7.0 Monophasic (53.5/27.5/19) 109 SAIB/NMP/PLGA DD 75:25 7.0 Monophasic (54.5/27.5/18) 110 SAIB/NMP/PLGA DD 65:35 6.5 Monophasic (54/26/20) 111 SAIB/PC/PLGA DD 75:25 7.0 Monophasic (37/43/20) 112 SAIB/PC/PLGA DD 75:25 7.0 Monophasic (30/50/20) 113 SAIB/PC/DMSO/PLGA DD 75:25 7.0 Monophasic (48/16/16/20) 114 SAIB/PC/DMSO/PLGA DD 75:25 7.0 Monophasic (44/18/18/20) 115 SAIB/PC/DMSO/PLGA DD 75:25 7.0 Monophasic (46/17/17/20) 116 SAIB/NMP/PLGA DD 75:25 7.0 Monophasic (48/32/20) 117 SAIB/NMP/PLGA DD 90:10 6.6 Monophasic (46/34/20) 118 SAIB/NMP/PLGA C8 65:35 5.4 Monophasic (55/25/20) 119 SAIB/NMP/PLGA C16 65:35 5.8 Monophasic (55/25/20) 120 SAIB/NMP/PLGA DD 90:10 6.6 Monophasic (48/32/20) 121 SAIB/DMSO/PLGA C8 65:35 5.4 Turbid (55/25/20) 122 SAIB/NMP/PLGA C8 65:35 5.4 Monophasic (47/35/18) 123 SAIB/DMSO/PLGA C16 65:35 5.8 Monophasic (55/25/20) 124 SAIB/PC/PLGA C8 65:35 5.4 Monophasic (43/37/20) 125 SAIB/PC/PLGA C16 65:35 5.8 Monophasic (43/37/20) 126 SAIB/NMP/PLA DD 100:0 13.9 Monophasic (55/25/20) Example 5: Olanzapine In Vitro Release from Formulations Comprising Various Polymers and Solvents As discussed in more detail below, this Example was directed to comparing the olanzapine in vitro release behavior of formulations comprising olanzapine, sucrose acetate isobutyrate, various solvents (propylene carbonate, benzyl benzoate, dimethylsulfoxide), and polymer (poly(lactic acid) or poly(lactic acid)(glycolic acid) with initiated with dodecanol (DD)).", "Vehicle preparation was similar to that described in representative Example 2 above.", "Olanzapine was added to the vehicle followed by homogenization.", "Specifically, the in vitro release behavior of the following formulations was characterized.", "PLGA or PLA Formulation Mw No.", "Formulation Initiator L:G (kDa) O1 SAIB/PC/PLGA/OLZ DD 65:35 6.5 (44/20/16/20) O2 SAIB/BB/PLGA/OLZ DD 65:35 6.5 (44/20/16/20) O3 SAIB/DMSO/PLGA/OLZ DD 65:35 6.5 (43/37/20) Release rate from olanzapine was measured using two techniques.", "In a dialysis tubing technique, 0.5 mL samples were placed in dialysis tubing in 100 mL PBS w/ 2% SDS.", "The samples were moved to new media for each time point (n=4).", "In the other technique, 0.5 mL samples were placed in 1000 mL PBS w/ 2% SDS in a USP Apparatus 2 (n=2).", "The release profiles from the formulations, as measured by the dialysis technique, are shown in FIG.", "7.The release profiles, as measured by the dialysis and USP techniques, from formulations O1 and O3 are shown in FIGS.", "8 and 9, respectively.", "These FIGS.", "show olanzapine release beyond 30 days.", "Example 6: Exenatide In Vitro Release from Formulations Comprising Various Polymers and Solvents As discussed in more detail below, this Example was directed to comparing the exenatide in vitro release behavior of formulations comprising exenatide, sucrose acetate isobutyrate, various solvents (N-methyl-pyrrolidone, propylene carbonate, and dimethyl sulfoxide), and polymer (poly(lactic acid)(glycolic acid) with different initiators such as dodecanol (DD), 1-octanol (C8), and 1-hexadecanol (C16).", "Vehicle preparation was similar to that described in representative Example 2 above.", "Exenatide was added to the vehicle followed by mixing.", "Specifically, the in vitro release behavior of the following formulations was characterized.", "PLGA Exenatide/ Formulation Mw Formulation No.", "Vehicle Initiator L:G (kDa) (mg/g) E1 SAIB/NMP/PLGA DD 75:25 7.0 17.6 (50/30/20) E2 SAIB/PC/PLGA C8 65:35 5.4 16.4 (43/37/20) E3 SAIB/PC/PLGA C16 65:35 5.8 17.0 (43/37/20) E4 SAIB/DMSO/PLGA C8 65:35 5.4 17.0 (47/35/18) E5 SAIB/DMSO/PLGA C16 65:35 5.8 17.2 (55/25/20) An aliquot (0.1 mL) of each composition was placed in a 2 mL conical vial with 1 mL of Dulbecco's Phosphate Buffered Saline (PBS) at 37° C., which vial was placed in an orbital shaker at 100 rpm (n=3).", "The release into the PBS was monitored for up to 6 days.", "The cumulative release profiles from the formulations comprising propylene carbonate and dimethylsulfoxide are shown in FIGS.", "10 and 11, respectively.", "These FIGS.", "show exenatide release up to 150 hours.", "The cumulative release profile from the formulation comprising N-methyl-pyrrolidone is not shown because the exenatide degraded in the formulation.", "The below Table lists the potency (% recovery) of exenatide depots at time 0.Exenatide % Recovery weight (Exenatide wt by (mg) by HPLC/Exenatide theoretical Exenatide wt by theoretical Formulation Vehicle Formulation weight wt (mg) by wt No.", "composition weight (mg) calculation HPLC calculation) * 100 E1A SAIB/NMP/PLGA 110.4 1.943 2.158 111.1 E1B (Dodecanol 114.0 2.006 2.204 109.9 initiated) = 50/30/20 E2A SAIB/PC/PLGA (1- 123.4 2.024 2.322 114.7 E2B Octanol initiated) = 121.1 1.986 2.210 111.3 43/37/20 E3A SAIB/PC/PLGA (1- 116.4 1.979 2.255 114.0 E3B Hexadecanol 122.8 2.088 2.370 113.5 initiated) = 43/37/20 E4A SAIB/DMSO/PLGA 117.4 1.996 1.968 98.6 E4B (1-Octanol 114.4 1.945 2.047 105.2 initiated) = 47/35/18 E5A SAIB/DMSO/PLGA 114.1 1.963 1.263 64.3 E5B (1-Hexadecanol 119.1 2.049 2.049 72.3 E5C initiated) = 55/25/20 130.8 2.250 0.333 14.8 E5D 118.2 2.033 0.356 17.5 *Formulations E5C and E5D were stored at RT for 6 days prior to extraction.", "Exenatide formulation was not stable.", "The below Table lists the mass balance (the sum of % cumulative release of exenatide and % exenatide left in the depot after up to 6 days in the release medium) for all five exenatide depots.", "Exenatide Exenatide Mass balance weight wt (mg) % (% Cumulative (mg) by left in the Remaining % release + % Formulation Formulation weight Depot by left in the Cumulative remaining left in No.", "wt (mg) calculation HPLC Depot release the depot) E1C 113.4 1.996 * * * * E1D 110.8 1.950 * * * * E1E 111.2 1.957 * * * * E2C 118.1 1.937 0.318 16.4 81.7 98.1 E2D 116.6 1.912 0.356 18.6 81.3 99.9 E2E 120.0 1.968 0.393 20.0 82.9 102.9 E3C 122.9 2.089 1.806 86.4 13.8 110.2 E3D 120.8 2.054 0.643 31.3 27.3 58.6 E3E 123.0 2.091 1.841 88.1 18.1 106.2 E4C 118.5 2.015 0.204 10.1 91.5 101.6 E4D 117.8 2.003 0.651 32.5 59.4 91.9 E4E 117.9 2.004 0.974 48.6 51.9 100.5 E5E 111.9 1.925 0.643 33.4 65.1 98.5 E5F 105.6 1.816 1.373 75.6 23.6 99.2 E5G 110.4 1.899 0.898 47.3 25.6 72.9 * Exenatide degraded in formulation.", "Example 7: Risperidone Formulations Various risperidone formulations, such as those shown in Table 2, were prepared.", "Formulation Nos.", "R1 to R6 were solutions.", "Otherwise, the formulations were suspensions of risperidone.", "In Table 2, the proportion of vehicle components is shown in parts by weight, unless otherwise indicated.", "Table 2 shows that the risperidone particles used to make the compositions were sometimes unmilled, but were typically milled by wet milling or jet milling.", "The wet milling process was conducted using a standard agitator bead mill, such as Dynomill/MULTILAB from WAB.", "Risperidone was added to water (pH may be adjusted with ammonia solution as necessary) to form a slurry.", "The slurry was introduced into an agitator bead mill containing ceramic beads.", "The slurry was milled, with temperature control to keep the slurry below 20° C., such as about 15° C. Milling time in the wet milling equipment was monitored to yield the desired particle size.", "The slurry was then quickly transferred to a lyophilizer and lyophilized using standard lyophilization cycles.", "Water and ammonia were essentially removed during lyophilization.", "A an exemplary lyophilization cycle is shown below: Freeze Cycle Shelf Temperature Set Point: −30° C. Duration: 180 mins (3 hrs) Primary Drying Shelf Temperature Set Point: −6° C. Vacuum Set point: 700 mT Duration: 1440 mins (24 hrs) Secondary Drying Shelf Temperature Set Point: 5° C. Vacuum Set point: 100 mT Duration: 1440 mins (24 hrs) As shown in Table 2, aqueous wet milling was sometimes performed in the presence of additives, the proportion of which is shown in parts by weight.", "When Pluronic F68 or Lutrol F68 was used as a milling additive without any other additives, the weight ratio of risperidone to F68 ranged from 95:5 to 70:30, unless otherwise indicated.", "The jet milling process involved comminuting the risperidone using a jet mill, e.g., using a Jet-O-Mizer jet mill.", "Multiple passes through the jet mill were sometimes used to achieve the desired reduction of the initial particle size.", "Liquid nitrogen was at least typically used to assist in the fracture of the particles during this milling process.", "Before milling, the as received particles typically had a median particle size, as measured by laser diffraction, ranging from 10 μm to 50 μm, with some as received lots having particles as large as 300 μm.", "When particles were jet milled, the resulting particles typically had a median particle size, as measured by laser diffraction, ranging from 2 μm to 10 μm.", "When particles were wet milled and lyophilized, the resulting particles typically had a median particle size, as measured by laser diffraction, ranging from 1 μm to 10 μm.", "Risperidone particles were combined with vehicle using standard methods.", "For instance, the particles were weighed in a glass jar.", "Vehicle was added.", "The mixture was homogenized using a PowerGen 1000 homogenizer, e.g., set at setting 2 to setting 4 for a total of 4-6 minutes.", "Table 2 includes the following abbreviations: RSP: risperidone SAIB: sucrose acetate isobutyrate NMP: N-methyl-pyrrolidone DMSO: dimethylsulfoxide CremophorEL: Cremophor EL Pluronic L44: Pluronic L44 BB: benzyl benzoate PC: propylene carbonate DMA: dimethylacetamide Solutol: Solutol® HS 15 polyoxyethylene esters of 12-hydroxystearic acid PLGA: poly(lactic acid)(glycolic acid) PLA: poly(lactic acid) PLA R202H: Resomer 202H poly(lactic acid) DD: dodecanol LA: lactic acid L:G: molar ratio of lactic acid to glycolic acid C8: octanol C16: 1-hexadecanol PVP: Plasdone C-17 polyvinylpyrrolidone F68: Lutrol F68 or Pluronic F68 HPMC: hydroxypropyl methylcellulose Tween 20: polyoxyethylene (20) sorbitan monolaurate Tween 80: polyoxyethylene (20) sorbitan monooleate CMC: sodium caboxymethylcellulose DOC: deoxycholate TABLE 2 PLGA or PLA Form.", "Mw RSP RSP Milling No.", "Vehicle Initiator L:G (kDa) (wt %) Conditions R1 SAIB/BA/EtOH/PLA R202H LA 100:0 14 10 Not milled (45/22.5/12.5/10) R2 SAIB/BA/EtOH/PLA R202H LA 100:0 14 10 Not milled (35/22.5/12.5/20) R3 SAIB/BA/EtOH/PLA R202H LA 100:0 14 10 Not milled (25/22.5/12.5/30) R4 SAIB/BA/BB/PLA R202H LA 100:0 14 10 Not milled (40/20/10/20) R5 SAIB/BA/BB/PLA R202H LA 100:0 14 10 Not milled (40/25/5/20) R6 SAIB/BA/BB/PLA R202H/RSP LA 100:0 14 10 Not milled (30/25/5/30/10) R7 SAIB/NMP/PLGA HD 65:35 5.1 10 Jet milled (55/25/20) R7* SAIB/NMP/PLGA HD 65:35 5.1 10 Not milled (55/25/20) R8 SAIB/DMSO/PLGA DD 65:35 6.3 10 Jet milled 50/22/18 R9 SAIB/DMSO/PLGA/PLA R202H DD 65:35 6.3 10 Jet milled 50/22/9/9 LA 100:0 14 R10 SAIB/NMP/PLGA DD 65:35 6.3 10 Jet milled (55/25/20) R11 SAIB/NMP/PLGA DD 65:35 6.3 17.5 Jet milled (55/25/20) R12 SAIB/NMP/PLGA DD 65:35 6.5 10 Jet milled (45/25/30) R13 SAIB/NMP/PLGA DD 65:35 6.5 17.5 Jet milled (45/25/30) R14 SAIB/NMP/PLGA DD 65:35 6.5 10 Jet milled (60/20/20) R15 SAIB/NMP/DMSO/PLGA DD 65:35 6.5 10 Jet milled (55/15/10/20) R16 SAIB/NMP/PLGA DD 65:35 6.5 17.5 Jet milled (60/20/20) R17 SAIB/NMP/PLGA DD 65:35 6.3 9 Jet milled (55/25/20) R18 SAIB/NMP/DMSO/PLGA DD 65:35 6.5 10 Jet milled (55/15/5/25) R19 SAIB/NMP/DMSO/PLGA DD 65:35 6.5 9 Jet milled (55/15/7/23) R20 SAIB/NMP/DMSO/PLGA DD 65:35 6.5 17.5 Jet milled (55/15/7/23) R21 SAIB/PC/PLGA DD 65:35 6.5 9 Jet milled (55/25/20) R22 SAIB/NMP/PLGA DD 65:35 6.3 9 Wet milled in 1 wt (55/25/20) % PEG4000 R23 SAIB/NMP/PLGA DD 65:35 6.3 9 Wet milled in 1 wt (55/25/20) % PVP R24 SAIB/PC/PLGA DD 65:35 6.5 9 Jet milled (50/30/20) R25 SAIB/NMP/PLGA DD 65:35 6.3 9 Not milled (55/25/20) R26 SAIB/NMP/PLGA DD 65:35 6.3 5 Jet milled (55/25/20) R27 SAIB/NMP/PLGA DD 65:35 6.3 25 Jet milled (55/25/20) R28 SAIB/NMP/PLGA DD 65:35 6.3 35 Jet milled (55/25/20) R29 SAIB/NMP/PLGA DD 65:35 6.3 9 Wet milled in 10 wt (55/25/20) % F68 R30 SAIB/NMP/PLGA DD 75:25 6.5 9 Jet milled (55/25/20) R31 SAIB/NMP/PLGA DD 75:25 6.5 9 Wet milled for (55/25/20) 10 minutes R32 SAIB/NMP/PLGA DD 75:25 6.5 9 Wet milled at (55/25/20) slow rpm for 35 minutes R33 SAIB/NMP/PLGA DD 75:25 6.5 9 Wet milled with (55/25/20) 95 RSP:5 PVP R34 SAIB/NMP/PLGA DD 75:25 6.5 9 Wet milled with (55/25/20) 95 RSP:5 HPMC R35 SAIB/NMP/PLGA DD 75:25 6.5 17.5 Wet milled for (55/25/20) 10 minutes R36 SAIB/NMP/PLGA DD 75:25 6.5 17.5 Wet milled at (55/25/20) slow rpm for 35 minutes R37 SAIB/NMP/PLGA DD 75:25 6.5 17.5 Wet milled with (55/25/20) 95 RSP:5 PVP R38 SAIB/NMP/PLGA DD 75:25 6.5 17.5 Wet milled (55/25/20) R39 SAIB/NMP/PLGA DD 75:25 6.9 9 Wet milled for (55/25/20) 10 minutes R40 SAIB/NMP/PLGA DD 75:25 6.9 9 Wet milled with (55/25/20) 95 RSP:5 PVP R41 SAIB/NMP/PLGA DD 75:25 6.9 9 Jet milled (55/25/20) R42 SAIB/NMP/PLGA DD 75:25 6.9 9 Wet milled (55/25/20) R43 SAIB/NMP/PLGA/PLA R202H DD 85:15 7.7 9 Wet milled (55/25/17.5/2.5) LA 100:0 14 R44 SAIB/NMP/PLGA DD 75:25 6.9 17.5 Wet milled (52.5/27.5/20) R45 SAIB/NMP/DMSO/PLGA DD 75:25 5.9 9 Wet milled (50/25/5/20) R46 SAIB/NMP/DMSO/PLGA DD 75:25 5.9 17.5 Wet milled (50/25/5/20) R47 SAIB/NMP/DMSO/PLGA DD 75:25 5.9 9 Wet milled (52/19/9/20) R48 SAIB/NMP/DMSO/PLGA DD 75:25 5.9 17.5 Wet milled (52/19/9/20) R49 SAIB/NMP/PLGA DD 75:25 6.9 17.5 Wet milled with (55/25/20) 95 RSP:5 PVP R50 SAIB/NMP/PLGA DD 75:25 6.9 9 Wet milled with (55/25/20) F68 R51 SAIB/NMP/PLGA DD 75:25 6.9 17.5 Wet milled with (55/25/20) F68 R52 SAIB/NMP/PLGA DD 75:25 6.9 9 Wet milled 8 (55/25/20) minutes R53 SAIB/NMP/PLGA DD 75:25 6.9 9 Wet milled 12 (50/30/20) minutes R54 SAIB/NMP/PLGA DD 75:25 6.9 9 Wet milled 12 (48/32/20) minutes R55 SAIB/NMP/PLGA DD 75:25 6.9 17.5 Wet milled 12 (48/32/20) minutes R56 SAIB/NMP/PLGA DD 75:25 6.9 9 Wet milled 12 (51/29/20) minutes R57 SAIB/NMP/PLGA DD 75:25 6.9 9 Wet milled 12 (50.5/29.5/20) minutes R58 SAIB/NMP/DMSO/PLGA DD 75:25 6.9 9 Wet milled 12 (50/25/5/20) minutes R59 SAIB/NMP/PLGA DD 75:25 6.9 9 Wet milled 12 (50/30/20) minutes R60 SAIB/NMP/DMSO/PLGA DD 75:25 6.9 9 Wet milled 12 (48/21/11/20) minutes R61 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 12 (55/25/20) minutes R62 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled (55/25/20) R63 SAIB/NMP/PLGA DD 75:25 7.0 9 Jet milled (55/25/20) R64 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 8 (55/25/20) minutes R65 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 12 (50/30/20) minutes R66 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled (50/30/20) R67 SAIB/NMP/PLGA DD 75:25 7.0 9 Jet milled (50/30/20) R68 SAIB/NMP/DMSO/PLGA DD 75:25 6.9 9 Jet milled (50/20/10/20) R69 SAIB/NMP/DMSO/PLGA DD 75:25 6.9 9 Wet milled (50/20/10/20) R70 SAIB/NMP/PLGA DD 75:25 7.0 17.5 Wet milled (46/34/20) R71 SAIB/NMP/PLGA DD 75:25 7.0 17.5 Wet milled (46/34/20) R72 SAIB/NMP/PLGA DD 75:25 7.0 17.5 Wet milled with (46/34/20) F68 R73 SAIB/NMP/DMSO/PLGA DD 75:25 7.0 17.5 Wet milled (46/22.5/11.5/20) R74 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 36 (50/30/20) minutes R75 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 46 (50/30/20) minutes R76 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 46 (50/30/20) minutes with 95 RSP:5 PVP R77 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 8 (50/30/20) minutes with 95 RSP:5 PVP R78 SAIB/NMP/DMSO/PLGA DD 75:25 7.0 9 Wet milled 46 (50/20/10/20) minutes R79 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 46 (52/29/19) minutes R80 0.9 wt % paliperidone in DD 75:25 7.0 9 Wet milled 90 SAIB/NMP/PLGA minutes (52/29/19) R81 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 46 (50/30/20) minutes with F68 R82 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 46 (50/30/20) minutes with 95 RSP:2.5 F68:2.5 Tween 80 R83 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 46 (55/25/20) minutes R84 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled with (50/30/20) 95 RSP:5 CMC R85 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 46 (50/30/20) minutes with 95 RSP:5 Tween 20 R86 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 46 (50/30/20) minutes with 95 RSP:2.5 PVP:2.5 DOC R87 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 90 (50/30/20) minutes with F68 R88 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 90 (50/30/20) minutes R89 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled with (50/30/20) 80 RSP:20 F68 R90 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled with (50/30/20) 95 RSP:5 mannitol R91 SAIB/PC/PLGA DD 75:25 7.0 9 Wet milled 46 (44/36.5/19.5) minutes R92 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled (44/36/20) R93 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled (40/40/20) R94 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled (31/49/20) R95 SAIB/NMP/PLGA DD 75:25 7.0 10 Wet milled 46 (50/30/20) minutes R96 SAIB/NMP/PLGA DD 75:25 7.0 10 Wet milled with (50/30/20) RSP:F68 95:5 R97 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled with (50/30/20) RSP:F68 90:10 R98 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled with (50/30/20) RSP:F68 80:20 R99 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled with (52/29/19) F68 R100 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 46 (58/27/15) minutes R101 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 46 (55/28/17) minutes R102 SAIB/PC/PLGA DD 75:25 7.0 9 Wet milled 46 (44/37/19) minutes R103 SAIB/NMP/DMSO/PLGA DD 75:25 7.0 9 Wet milled 90 (50/15.5/14.5/20) minutes R104 SAIB/NMP/DMSO/PLGA DD 75:25 7.0 9 Wet milled 90 (49.5/10/20.5/20) minutes R105 SAIB/DMSO/PLGA DD 75:25 7.0 9 Wet milled 90 (48/32/20) minutes R106 SAIB/PC/PLGA DD 75:25 7.0 9 Wet milled (38/42/20) R107 SAIB/PC/PLGA DD 75:25 7.0 9 Wet milled (34/46/20) R108 SAIB/PC/PLGA DD 75:25 7.0 9 Wet milled (28/52/20) R109 SAIB/NMP/DMSO/PLGA DD 75:25 7.0 9 Wet milled 90 (50/20/10/20) minutes R110 SAIB/NMP/DMSO/PLGA DD 75:25 7.0 9 Wet milled 90 (50/20/10/20) minutes with sucrose R111 SAIB/NMP/DMSO/PLGA DD 75:25 7.0 9 Wet milled 90 (50/20/10/20) minutes with trehalose R112 SAIB/NMP/DMSO/PLGA DD 75:25 7.0 9 Wet milled 180 (50/20/10/20) minutes with 95 RSP:5 CMC R113 SAIB/NMP/DMSO/PLGA DD 75:25 7.0 9 Wet milled with (50/20/10/20) 95 RSP:2.5 CMC:2.5 F68 R114 SAIB/NMP/DMSO/PLGA DD 75:25 7.0 9 Wet milled 180 (50/20/10/20) minutes with F68 R115 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 130 (50/30/20) minutes R116 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 130 (50/30/20) minutes with 95 RSP:5 arginine R117 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 130 (50/30/20) minutes with 95 RSP:5 dextran R118 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 130 (50/30/20) minutes with 95 RSP:2.5 PVP:2.5 DOC R119 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 240 (50/30/20) minutes R120 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 240 (50/30/20) minutes with DOC R121 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 240 (50/30/20) minutes with 95 RSP:2.5 DOC:2.5 F68 R122 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 240 (50/30/20) minutes with 95 RSP:2.5 PVP:2.5 DOC R123 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 240 (50/30/20) minutes with 95 RSP:2.5 PVP:2.5 CMC R124 SAIB/NMP/PLGA DD 75:25 7.0 9 Wet milled 90 (50/30/20) minutes with F68 R125 SAIB/PC/PLGA DD 75:25 7.0 9 Wet milled 200 (44/37/19) minutes R126 SAIB/NMP/PC/PLGA DD 75:25 7.0 9 Wet milled 90 (46/10/24/20) minutes R127 SAIB/NMP/PC/PLGA DD 75:25 7.0 10 Wet milled 90 (48/20/12/20) minutes R128 SAIB/DMA/PLGA DD 75:25 7.0 9 Wet milled 130 (56/24/20) minutes R129 SAIB/NMP/Miglyol/PLGA DD 75:25 7.0 9 Wet milled 180 (49.5/29.5/1/20) minutes R130 SAIB/NMP/Miglyol/PLGA DD 75:25 7.0 9 Wet milled 180 (47/28/5/20) minutes R131 SAIB/PC/PLGA DD 75:25 7.0 9 Wet milled (44/37/19) R132 SAIB/NMP/PC/PLGA DD 75:25 7.0 9 Wet milled (46/10/24/20) R133 SAIB/NMP/PLGA DD 75:25 7.0 9 Jet milled (54.5/27.5/18) R134 SAIB/PC/PLGA DD 75:25 7.0 17.5 Wet milled (37/43/20) R135 SAIB/PC/PLGA DD 75:25 7.0 17.5 Wet milled (30/50/20) R136 SAIB/PC/DMSO/PLGA DD 75:25 7.0 9 Wet milled (46/17/17/20) R137 SAIB/NMP/PLGA DD 75:25 7.0 8.9 Wet milled (50/30/20) R138 SAIB/NMP/PLGA DD 75:25 7.0 17.5 Wet milled (48/32/20) R139 SAIB/NMP/PLGA C8 65:35 5.4 9 Wet milled (55/25/20) R140 SAIB/NMP/PLGA C16 65:35 5.8 9 Wet milled (55/25/20) R141 SAIB/NMP/PLA DD 100:0 13.9 9 Wet milled (55/25/20) Example 8: Settling in N-Methylpyrrolidone and Propylene Carbonate Formulations As discussed in more detail below, this Example was directed to comparing the risperidone particle settling behavior of suspension formulations based on N-methylpyrrolidone as compared with suspension formulations based on propylene carbonate.", "Real-time settling was analyzed.", "Formulation No.", "R66 consisted of SAIB/NMP/PLGA/RSP in the following weight proportion: 45.5/27.3/18.2/9.0.Formulation No.", "R131 consisted of SAIB/PC/PLGA/RSP in the following weight proportions 40.0/33.7/17.3/9.0.It should be noted that Formulation Nos.", "R66 and R131 were formulated to yield approximately the same viscosity (see below Table).", "However, to achieve similar viscosities, more PC must be added to the vehicle, with a corresponding decrease in SAIB (and a minor decrease in PLGA).", "Formulation No.", "R66 Formulation No.", "131 (NMP formulation) (PC formulation) Placebo Vehicle SAIB/NMP/PLGA: SAIB/PC/PLGA: Composition 50/30/20 44/37/19 Placebo Vehicle 1.123 1.179 Density (gm/mL) Viscosity of 374 cP 372 cP placebo vehicle at 25° C. Viscosity of 2100-2300 cP @ 6-8 s−1 1750-1900 cP @ 6-8 s−1 placebo vehicle at 5° C. Risperidone 9.2 mg/mL 7.4 mg/mL solubility in vehicle Viscosity of 656 cP 721 cP formulation at 25° C.", "(i.e., with 9% RSP) Starting RSP particle size (post milling & lyophilization) for both Formulation No.", "R66 and Formulation No.", "R131 was D(0.1)=0.63 μm, D(0.5)=1.99 μm, and D(0.9)=3.94 μm.", "Formulation Nos.", "R66 and R131 were gamma irradiated at 15 kGy.", "The below Table shows the real-time settling of samples stored at the indicated conditions.", "About 2 mL of each of the formulations was placed in tubes.", "After the indicated storage times, 100 μL aliquots were removed from the very top, middle and bottom layer of the tubes and weighed into 25 mL volumetric flasks.", "Samples were extracted and assayed for the potency using HPLC.", "The below Table, which is graphically summarized in FIG.", "12, shows the real time settling behavior of Formulations No.", "R66 (NMP based) and Formulation No.", "R131 (PC based) at 5° C. Difference Storage % RSP (Bottom − Formulation Composition Condition Top-Bottom Top) R66 SAIB/NMP/PLGA/RSP T0 (post irradiation) 9.00% 0 45.5/27.3/18.2/9.0 6 months @−20° C. 8.8-8.9% 0.1% 10 months @−20° C. 8.8-8.8% 0 3 months @5° C. 8.9-9.3% 0.4% 6 months @5° C. 8.6-9.7% 1.1% 10 months @5° C. 6.7-9.8% 3.1% R131 SAIB/PC/PLGA/RSP T0 (post irradiation) 9.01% 0 6 months @5° C. 8.9-9.3% 0.4% 11 months @5° C. 9.3%-10.2% 0.9% 1 month @25° C. 8.9%-9.2% 0.3% 11 months @25° C. 8.6%-11.8% 3.2% The difference in the above-noted settling versus the difference in vehicle density is notable.", "As shown in the first Table of this Example, the viscosity of the placebo vehicle for Formulation No.", "R66 at 5° C. is slightly higher than the viscosity of the placebo vehicle for Formulation No.", "R131 at 5° C. The density of risperidone is 1.30 g/mL.", "Thus, the difference in density between risperidone and each of the vehicles was: ρ1−ρ2=1.30 g/mL−1.123 g/mL=0.177 g/mL for Formulation No.", "R66 ρ1−ρ2=1.30 g/mL−1.179 g/mL=0.121 g/mL for Formulation No.", "R131 Thus, the density difference between the placebo vehicles for Formulation Nos.", "R66 and R131 is about 46%.", "The concentration difference for real time settling is relatively higher.", "As shown above in the second Table of this Example, the difference in settling is 3.1% (bottom—top) for Formulation No.", "R66 at 10 months at 5° C. versus 0.9% (bottom—top) for Formulation No.", "R131 at 11 months at 5° C. In view of the above, the density difference is only about 46%, but the concentration difference for real-time settling is close to 250%.", "Example 9: Risperidone In Vitro Release from Formulations Comprising Various Polymers As discussed in more detail below, this Example was directed to comparing the risperidone in vitro release behavior of formulations comprising risperidone, sucrose acetate isobutyrate, N-methyl-pyrrolidone, and polymer (poly(lactic acid)(glycolic acid) or poly(lactic acid)).", "Specifically, the in vitro release behavior of the following formulations was characterized.", "PLGA or PLA Mw RSP RSP Milling Formulation No.", "Vehicle Initiator L:G (kDa) (wt %) Conditions R139 SAIB/NMP/PLGA C8 65:35 5.4 9 Wet milled (55/25/20) R140 SAIB/NMP/PLGA C16 65:35 5.8 9 Wet milled (55/25/20) R141 SAIB/NMP/PLA DD 100:0 13.9 9 Wet milled (55/25/20) An aliquot (0.5 mL) of each composition was placed in 100 mL of phosphate buffered saline (PBS) at 37° C. with gentle stirring (n=4).", "The release into the PBS was monitored for 13 days.", "The cumulative release profiles are shown in FIGS.", "13 to 15.In summary, Formulation Nos.", "R139 and R140 showed small initial bursts and sustained release for at least 13 days.", "Formulation No.", "R140 had a small initial burst and then showed release of relatively small amounts of risperidone.", "Thus, extended release of risperidone was observed over a period of days to weeks.", "Example 10: Risperidone In Vivo Release in Rats As discussed in more detail below, this Example was directed to in vivo release in rats of risperidone from formulations comprising risperidone, sucrose acetate isobutyrate, solvent (e.g., benzyl alcohol, ethanol, benzyl benzoate, and N-methyl-pyrrolidone), and polymer (e.g., hexanediol-initiated poly(lactic acid) (PLA) and poly(lactic acid)(glycolic acid) (PLGA)).", "The PK of each of seven risperidone-vehicle formulations, shown in the below Table, was evaluated in male Sprague-Dawley rats (N=6/group) following SC administration.", "The risperidone in the formulations of Groups 1-6 was in solution, whereas the risperidone in the formulation of Group 7 was in suspension.", "A control group in which risperidone was delivered by IV bolus administration was also included for the purpose of determining SC bioavailability.", "Formulation PLGA or PLA Dose Formulation Composition Mw Dose Volume Group No.", "[wt %] Initiator L:G (kDa) Route (μL) 1 R1 SAIB/BA/EtOH/PLA LA 100:0 14 SC 100 R202H/RSP (45/22.5/12.5/10/10) 2 R2 SAIB/BA/EtOH/PLA LA 100:0 14 SC 100 R202H/RSP (35/22.5/12.5/20/10) 3 R3 SAIB/BA/EtOH/PLA LA 100:0 14 SC 100 R202H/RSP (25/22.5/12.5/30/10) 4 R4 SAIB/BA/BB/PLA LA 100:0 14 SC 100 R202H/RSP (40/20/10/20/10) 5 R5 SAIB/BA/BB/PLA LA 100:0 14 SC 100 R202H/RSP (40/25/5/20/10) 6 R6 SAIB/BA/BB/PLA LA 100:0 14 SC 100 R202H/RSP (30/25/5/30/10) 7 R7 10 wt % RSP in HD 65:35 5.1 SC 100 SAIB/NMP/PLGA (55/25/20) 8 NA 0.4 mg/mL RSP in NA NA NA IV 300 pH 5.4 citrate buffer bolus RSP = Risperidone Blood samples were obtained at several intervals beginning on the day of dosing continuing up to Day 28.The concentration of risperidone and 9-OH risperidone (a major metabolite that is pharmacologically active) in rat plasma samples was determined using an HPLC/MS/MS method.", "The resulting PK profiles in rats are shown in FIGS.", "16 to 18.FIG.", "16 shows the mean risperidone PK profiles.", "FIG.", "17 shows the mean active moiety (risperidone+9-hydroxy risperidone) PK profiles.", "FIG.", "18 shows the risperidone PK profile of individual rats from Group 7.The results from this study showed relatively large initial release of drug/metabolite into the systemic circulation after subcutaneous (SC) administration of risperidone-solution formulations in rats.", "Example 11: Gamma Radiation Stability Study As discussed in more detail below, this Example was directed to evaluating the gamma radiation stability of formulations with or without risperidone comprising sucrose acetate isobutyrate, N-methyl-pyrrolidone, and hexanediol-initiated poly(lactic acid)(glycolic acid).", "Specifically, samples of the below formulations were stored neat at 37° C., with or without being treated with 25 kGy of gamma irradiation.", "PLGA Gamma Formulation Formulation Mw Radiation No.", "Composition [wt %] Initiator L:G (kDa) (kGy) NA SAIB/NMP/PLGA HD 65:35 5.1 None (55/25/20) NA SAIB/NMP/PLGA HD 65:35 5.1 25 (55/25/20) R7 10 wt % RSP in HD 65:35 5.1 None SAIB/NMP/PLGA (55/25/20) R7 10 wt % RSP in HD 65:35 5.1 25 SAIB/NMP/PLGA (55/25/20) The molecular weight of the polymer was monitored for degradation.", "Results are shown in FIG.", "19, which shows that the presence or absence of risperidone affected molecular weight more than gamma irradiation.", "Example 12: Risperidone In Vivo Release in Rats As discussed in more detail below, this Example was directed to in vivo release in rats of risperidone from formulations comprising risperidone, sucrose acetate isobutyrate, solvent (N-methyl-pyrrolidone or dimethylsulfoxide), dodecanol-initiated poly(lactic acid)(glycolic acid), and optionally poly(lactic acid).", "The risperidone formulations were generally prepared as described above.", "The risperidone particles were jet milled.", "The PK of each of three risperidone-vehicle formulations, shown in the below Table, was evaluated in male Sprague-Dawley rats (N=6/group) following SC administration.", "The risperidone in each of these formulations was milled.", "A control group in which risperidone was delivered by IV bolus administration was also included for the purpose of determining SC bioavailability.", "Formulation Composition [wt %] (nominal RSP Nominal Nominal particle size) (RSP PLGA or PLA RSP RSP Dose Form.", "solubility in Mw Dose Dose Dose Volume Group No.", "vehicle) Initiator L:G (kDa) Route (mg) (mg/kg) (μL) 1 R10 SAIB/NMP/PLGA/RSP DD 65:35 6.3 SC 17 49 150 50/22/18/10 (2-5 μm) (8 mg/mL) 2 R8 SAIB/DMSO/PLGA/RSP DD 65:35 6.3 SC 17 49 150 50/22/18/10 (2-5 μm) (6 mg/mL) 3 R9 SAIB/DMSO/PLGA/PLA DD 65:35 6.3 SC 17 49 150 R202H/RSP LA 100:0 14 50/22/9/9/10 (2-5 μm) (7 mg/mL) 4 NA 0.4 mg/mL RSP in NA NA NA IV 0.12 0.34 300 citrate buffer bolus Nominal dose based on a 350 g rat RSP = Risperidone Blood samples were obtained at several intervals beginning on the day of dosing continuing up to Day 28.The concentration of risperidone and 9-OH risperidone (a major metabolite) in rat plasma samples was determined using an HPLC/MS/MS method.", "The resulting PK profiles in rats are shown in FIGS.", "20 to 22.FIG.", "20 shows the risperidone PK profiles.", "FIG.", "21 shows the active moiety (risperidone+9-hydroxy risperidone) PK profile.", "The data indicate that a similar kinetic profile exists for both parent drug and its active metabolite.", "FIG.", "22 shows the active moiety PK profile of individual rats for Group 1.The PK profile in rats obtained with Formulation No.", "R10 indicated that risperidone was released into the systemic circulation in a slow and sustained manner over the 28-day post-administration blood sampling period.", "Plasma levels of risperidone gradually declined following administration and no evidence of dose dumping or large increases in drug levels were observed.", "Similar profiles were noted with other formulations tested in this study.", "Peak levels of risperidone and 9-OH risperidone for Formulation No.", "R10 are compared with those for the IV bolus in the below Table.", "RSP 9-OH RSP Group Cmax ng/mL Tmax Cmax ng/mL Tmax 1 (49 mg/kg), 174 ± 50 0.04 days 81 ± 23 0.04 days SC RSP in Citrate 512 ± 176 0.03 hr 50 ± 15 1.0 hr Buffer pH 5; (0.34 mg/kg), IV Cmax data expressed as Mean ± standard deviation; Tmax data expressed as Median values RSP = Risperidone 9-OH RSP = 9-hydroxy risperidone Peak risperidone levels following a risperidone dose of 49 mg/kg were approximately one-third of those following a 0.34 mg/kg IV dose of risperidone.", "The below Table summarizes exposure (AUC) and bioavailability data for risperidone, 9-OH risperidone and active moiety including that associated with initial burst (AUC0-24 hr) and over 28 days following the administration of Formulation No.", "R10.Exposure over the first 24 hours was ˜9.3% of the total AUC and plasma levels were sustained over 21-28 days indicating a lack of dose dumping.", "The data from this study provided additional information that risperidone-vehicle formulations administered subcutaneously were capable of providing for the sustained release of risperidone without significant bursts of parent drug.", "The extent of exposure over the initial 24 hours seen in this study provided empirical proof that risperidone-vehicle administered subcutaneously would not result in high levels of risperidone and associated acute toxicity.", "AUC0-24 hr/ AUC0-24 hr AUC0-28 d AUC0-28 d × Tmax Cmax T1/2 (day- (day- 100 Analyte (days) (ng/mL) (days) ng/mL) ng/mL) (%) RSP 0.04 ± 0 174 ± 50 6.59 ± 4.05 64.1 ± 24.9 701 ± 189 9.3 ± 2.8 9-OH RSP 0.08 ± 0.06 81 ± 23 5.64 ± 3.08 38.9 ± 15.9 449 ± 129 8.6 ± 1.9 AM 0.04 ± 0 251 ± 68 6.41 ± 3.71 103 ± 40.7 1150 ± 305 9.0 ± 2.4 Data expressed as Mean ± standard deviation (Median ± % co-efficient of variation values reported for Tmax) RSP = Risperidone 9-OH RSP = 9-hydroxy risperidone AM = Active Moiety As shown in FIGS.", "23 and 24, Formulation No.", "R10 (milled drug, dodecanol-initiated PLGA) resulted in significantly less burst than Formulation No.", "R7 (milled drug, hexanediol-initiated PLGA).", "Formulation No.", "R10 appears to have corrected the plasma level drop-off (after 240 hours) observed with Formulation No.", "R7 with milled drug.", "FIG.", "25 shows that Formulation No.", "R10 provides a better AUC profile than observed with Formulation No.", "R7 with milled drug.", "In a separate study, Formulation No.", "R7* (with as received risperidone) was administered to rats.", "The resulting PK profile of Formulation No.", "R7* (with unmilled risperidone) was similar to that of Formulation No.", "R10 through 504 hours (3 wks).", "In summary, the results from this study demonstrated that continuous and sustained release of risperidone was achievable with subcutaneous administration of Formulation No.", "R10 (dodecanol-initiated PLGA) in rats in the absence of an excessive initial release of drug/metabolite into the systemic circulation.", "Example 13: Risperidone In Vivo Release in Dogs As discussed in more detail below, this Example was directed to in vivo release in dogs of risperidone from formulations comprising risperidone, sucrose acetate isobutyrate, solvent, and dodecanol-initiated poly(lactic acid)(glycolic acid) (L:G=75:25).", "This single dose PK study in beagle dogs evaluated four risperidone-vehicle formulations, shown in the below Table.", "The four formulations were each administered once to separate groups of five male beagle dogs (animals 3-5.5 years of age and weighing 8.4-11.4 kg at study initiation) subcutaneously (in the midscapular area) at a nominal dose and dose volume of 53 mg and 0.5 mL, respectively.", "Another group of five males was dosed IV with risperidone (0.6 mg total dose at a dose volume of 5 mL).", "The formulations which were tested (and their components) and the study design is provided in the below Table.", "Formulation Composition Nominal Nominal SAIB/NMP/PC/PLGA/RSP PLGA RSP RSP Dose Form.", "[wt %] (nominal RSP Mw Dose Dose Dose Volume Group No.", "particle size) Initiator L:G (kDa) Route (mg) (mg/kg) (mL) 1 NA 0.12 mg/mL RSP in citrate NA NA NA IV 0.6 0.06 5 buffer bolus 2 R66 46/27/0/18/9 DD 75:25 7.0 SC 53 5.3 0.5 (0.5-2 μm) 3 R131 40/0/34/17/9 DD 75:25 7.0 SC 52 5.2 0.5 (0.5-2 μm) 4 R126 42/9/22/18/9 DD 75:25 7.0 SC 52 5.2 0.5 (0.5-2 μm) 5 R133 50/25/0/16/9 DD 75:25 7.0 SC 52 5.2 0.5 (2-5 μm) Nominal dose based on a 10 kg dog Study report describes composition of vehicle into which, specified wt % of risperidone is dispersed.", "RSP = risperidone PC = propylene carbonate Each of the formulations was irradiated at 15 kGy.", "The formulations were stable on irradiation and on storage.", "The formulations had greater than 99% risperidone purity after 6 months storage at 5 C. For Formulation No.", "R66, PLGA molecular weight after 6 months storage at 5 C was greater than 90% of initial molecular weight.", "Blood was collected for the analyzed for risperidone and 9-OH risperidone levels in plasma, up to and including 42 days after treatment.", "Clinical signs were recorded daily and body weights recorded weekly starting with the day of dosing (Day 0).", "All animals in Groups 3 and 4 and the majority of animals in Groups 1, 2 and 5 exhibited clinical signs consistent with the pharmacological properties of risperidone on the day of dosing.", "The dosage administered to the dogs was approximately 7-fold greater on a body weight basis than the human dose used in the Phase 1 trial described in Example 14, below.", "These observations included hypoactivity, tremors that affected the front legs and/or the whole body and hyperactivity, manifested by chewing the hardware in the cage.", "Aside from one Group 3 and one Group 5 animal that exhibited similar clinical signs on Day 2, no other test article-related clinical signs were observed.", "No differences in body weight were seen amongst the different groups.", "Mean body weights declined slightly in all groups the first week of the study but remained stable or increased back toward baseline levels thereafter.", "Based on AUC values, the overall exposure of dogs to risperidone and 9-OH risperidone during the 42-day sample collection period appeared to be similar for animals given the different risperidone-vehicle formulations.", "Risperidone exhibited good bioavailability following SC administration to dogs with Formulation No.", "R66.The PK profile following the SC administration of Formulation No.", "R66 was characterized by the slow and sustained release of drug into plasma with levels declining over time and therapeutically active levels being maintained for 4 weeks (FIG.", "26).", "Mean levels of risperidone and active moiety did not exceed 181 ng/mL and 350 ng/mL (average Cmax for risperidone and active moiety following 2 mg oral Risperdal administration) respectively, for Formulation No.", "R66 indicating drug burst/dumping did not occur.", "A comparison of Group 2 (Formulation No.", "R66, 0.5-2 μm) and Group 5 (Formulation No.", "R133, 2-5 μm) demonstrated that for formulations with the same viscosity, but different particle size (i.e., 0.5-2 μm vs. 2-5 μm for Groups 2 and 5, respectively), and slightly different composition, the risperidone PK profile was nearly identical (FIG.", "27).", "A summary of the PK parameters obtained with Formulation No.", "R66 is provided in the below Table.", "AUC0-24 hr/ AUC0-28 d × Cmax T1/2 AUC0-24 hr AUC0-28 d 100 Flast Analyte Tmax (days) (ng/mL) (days) (day-ng/mL) (day-ng/mL) (%) (%) RSP 0.142 ± 0.056 73.0 ± 54.5 7.2 ± 2.7 35.1 ± 34.9 431 ± 342 7.4 ± 1.8 114 9-OH RSP 8.6 ± 7.1 158 ± 79.0 12.3 ± 9.5 94.1 ± 45.5 2329 ± 1023 4.0 ± 0.3 NC AM 10.6 ± 7.9 187 ± 97.2 10.2 ± 7.7 130 ± 78.6 2763 ± 1323 4.5 ± 0.6 97 Data expressed as Mean ± standard deviation Bioavalability vs. IV bolus RSP = Risperidone 9-OH RSP = 9-hydroxy risperidone AM = Active Moiety = RSP + 9-OH RSP NC = Not Calculated In summary, the results of this study indicated that Formulation No.", "R66 exhibited a PK profile consistent with a low initial burst and no dose dumping and prolonged, continuous, and sustained release into plasma.", "Example 14: A Pilot, Open-Label, Non-Randomized, Single Ascending Dose, Safety and Pharmacokinetic Phase I Clinical Trial with Injectable Risperidone-Vehicle and the DosePro® Delivery System in Patients with Chronic, Stable Schizophrenia or Schizoaffective Disorder The primary objectives of this study were: To assess the pharmacokinetic (PK) profile of a risperidone-vehicle formulation administered as a single subcutaneous (SC) injection via needle and syringe or via the DosePro® needle-free Delivery System administered at an equivalent dose.", "To evaluate the safety and tolerability of a risperidone-vehicle formulation administered as a single SC injection or via the DosePro® needle-free delivery system administered to the abdominal region.", "This was an open-label, single ascending dose (SAD), safety and PK study in patients with chronic, stable schizophrenia or schizoaffective disorder.", "Forty patients (male and female) with schizophrenia or schizoaffective disorder on antipsychotic maintenance medication were enrolled into three cohorts (10 patients per cohort).", "The drug product was supplied in 2 mL glass vials, containing a minimum of 1.0 mL of risperidone-vehicle formulation.", "Each 1.0 mL drug product comprised 100 mg of risperidone formulated with vehicle.", "The risperidone-vehicle formulation (Formulation No.", "R137) was comprised of the 8.9 wt % of risperidone formulated with inactive ingredients SAIB, NMP, and PLGA-DD (L:G=75:25; Mw=7.0 kDa) at a weight ratio of 50/30/20.The storage condition for the risperidone-vehicle formulation was −20° C. and was administered at room temperature.", "Patients were administered study drug as follows: Cohort A—25 mg of risperidone-vehicle formulation was administered as a SC injection of 0.25 mL (100 mg/mL concentration) in the abdominal region.", "Cohort B—50 mg of Risperidone-vehicle formulation was administered as 0.5 mL (100 mg/mL concentration) via the DosePro® needle-free delivery system in the abdominal region.", "Cohort C—50 mg of risperidone-vehicle formulation was administered as a SC injection of 0.5 mL (100 mg/mL concentration) in the abdominal region.", "Single dose PK parameters for risperidone, 9-OH risperidone, and active moiety were analyzed from the concentration time data.", "The results from Cohort A are shown in FIG.", "28.The results from Cohort B are shown in FIG.", "29.The results from Cohort C are shown in FIG.", "30.Extended risperidone delivery was observed for periods greater than 4 weeks.", "The foregoing embodiments and advantages are merely exemplary and are not to be construed as limiting the present disclosure.", "The description of the present disclosure is intended to be illustrative, and not to limit the scope of the claims.", "Many alternatives, modifications, and variations will be apparent to those skilled in the art.", "Having now fully described this disclosure, it will be understood to those of ordinary skill in the art that the methods of the present disclosure can be carried out with a wide and equivalent range of conditions, formulations, and other parameters without departing from the scope of the disclosure or any embodiments thereof.", "All patents and publications cited herein are hereby fully incorporated by reference in their entirety.", "The citation of any publication is for its disclosure prior to the filing date and should not be construed as an admission that such publication is prior art or that the present disclosure is not entitled to antedate such publication by virtue of prior acts of invention." ] ]
Patent_15872522
[ [ "LIQUID COOLING SYSTEM FOR SERVER", "A method of cooling a computer server that includes a plurality of server modules, and is positioned in an enclosed room, includes transferring heat generated by a server module of the plurality of server modules to a hot plate of a liquid cooling system.", "The liquid cooling system may be positioned within the server module, and the hot plate may have a surface exposed to the enclosed room.", "The method may also include positioning a cold plate of a room-level cooling system in thermal contact with the hot plate.", "The method may also include directing a cooling medium through the room-level cooling system to transfer heat from the hot plate to a cooling unit positioned outside the room." ], [ "1.A method of cooling a computer server having a plurality of server modules housed in a server rack, the method comprising: circulating a first coolant through a first liquid cooling loop positioned in a first server module, the first liquid cooling loop comprising: a first cold plate dimensioned to thermally coupled to a portion of the first server module; a first hot plate; and a first plurality of conduits to circulate the first coolant through the first cold plate and the first hot plate; transferring heat generated by the first server module to the first coolant through the first cold plate and transferring the heat in the first coolant to the first hot plate; circulating a second coolant through a second liquid cooling loop positioned in a second server module, the second liquid cooling loop comprising: a second cold plate dimensioned to thermally coupled to a portion of the second server module; a second hot plate; and a second plurality of conduits to circulate the second coolant through the second cold plate and the second hot plate; transferring heat generated by the second server module to the second coolant through the second cold plate and transferring the heat in the second coolant to the second hot plate; circulating a third coolant through a rack liquid cooling loop, the rack liquid cooling loop comprising: a third cold plate that thermally couples to the first hot plate; a fourth cold plate that thermally couples to the second hot plate; a cooling unit; and a third plurality of conduits to circulate the third coolant through the third cold plate, the fourth cold plate, and the cooling unit; wherein the third cold plate and the fourth cold plate are positioned external to the first server module and the second server module; transferring heat from the first hot plate and second hot plate to the third coolant through the third cold plate and the fourth cold plate, wherein the heat is discharged from the third coolant by the cooling unit.", "2.The method of claim 1, where at least one of the first liquid cooling loop, the second liquid cooling loop, and the rack liquid cooling loop is an open loop.", "3.The method of claim 1, wherein the cooling unit includes at least one of a chiller or a heat exchanger.", "4.The method of claim 1, wherein the cooling unit transfers heat to an HVAC system.", "5.The method of claim 1, wherein the first server module includes at least one electronic heat generating device and the first cold plate thermally couples to the electronic heat generating device.", "6.The method of claim 1, wherein the second server module includes at least one electronic heat generating device and the second cold plate thermally couples to the electronic heat generating device.", "7.The method of claim 1, wherein the first cold plate includes a reservoir for receiving the first coolant and the second cold plate includes a reservoir for receiving the second coolant.", "8.The method of claim 7, wherein at least one of the first cold plate and second cold plate includes a plurality of fins that project into the reservoir.", "9.The method of claim 1, wherein a thermal interface pad is positioned between at least one of the first hot plate and the third cold plate or the second hot plate and the fourth cold plate.", "10.The method of claim 1, wherein the third plurality of conduits circulate the third coolant from with a server room containing the computer server to a location external to the server room where the cooling unit is located.", "11.The method claim 1, wherein the rack liquid cooling loop includes a pump configured to assist in circulating the third coolant.", "12.The method of claim 1, wherein the rack liquid cooling loop includes a fifth cold plate that thermally couples to a heat generating component of the rack and third coolant circulates through the fifth cold plate in order to transfer heat from the heat generating component to the cooling unit." ], [ "<SOH> III.", "BACKGROUND <EOH>Electronic systems, such as, for example, computer systems include several integrated circuit (IC) devices that generate heat during operation.", "For effective operation of the computer system, the temperature of the IC devices have to be maintained within acceptable limits.", "While the problem of heat removal from IC devices is an old one, this problem has increased in recent years due to greater numbers of transistors that are packed into a single IC device while reducing the physical size of the device.", "Increasing number of transistors compacted into a smaller area results in a greater concentration of heat that must be removed from that smaller area.", "Bundling multiple computer systems together, such as, for example, in a server, further aggravates the heat removal problem by increasing the amount of heat that has to be removed from a relatively small area.", "In a typical computer server (“server”), multiple computer server modules (“modules”) are stacked together in a rack or a case to consolidate network resources and minimize floor space.", "Modules which are designed for use in a server configuration are typically characterized by a motherboard comprising heat generating electronic components (such as IC devices) housed in a modular chassis or case, which in turn is mounted together with other similar modules, in a rack, blade cabinet, blade server, or other support structure.", "In practice, multiple servers (each comprising several modules) are typically located in an enclosed space such as a server room or a data center.", "During operation, the electronic components in the individual modules generate heat which must be removed for effective functioning of the server.", "FIG.", "1 illustrates an prior art method used to cool multiple servers (each containing multiple modules) housed in an enclosed environment such as, for example, a server room.", "In such a prior art system, cooling fans are used circulate ambient air from the server room through the multiple modules of a server to absorb heat therefrom.", "In the prior art system, cool air directed into the server room through a cold air plenum is passed through the servers to absorb heat generated by IC devices and other heat generating components therein.", "After absorbing the generated heat, the heated air is exhausted back into the server room.", "This heated air is directed through a warm air plenum to a computer room air conditioning (CRAC) system to cool the air and recirculate it back to the server room through the cold air plenum.", "It is known that a large portion (greater than about 31%) of the energy consumption of a typical server room is used in the operation of the CRAC system, and that significant energy savings and resultant green house gas reduction can be achieved by improving the efficiency of the CRAC system.", "“Data Center Energy Characterization Study Site Report,” February 2001, available at http://hightech.lbl.gov/documents/DATA_CENTERS/DC_Benchmarking/Data_Center_Facility1.pdf; “Energy Consumption of Information Technology Data Centers,” and references cited therein, Iyengar et al., December 2010, available at http://www.electronics-cooling.com/2010/12/energy-consumption-of-information-technology-data-centers/.", "Improving the cooling efficiency of servers housed in a server room thereby enables more efficient utilization and conservation of available energy resources, and green house gas emission reduction.", "The disclosed liquid cooling systems and methods are directed to an energy efficient approach of cooling one or more servers located in an enclosed environment, such as a server room." ], [ "<SOH> IV.", "SUMMARY OF THE DISCLOSURE <EOH>In one aspect, a method of cooling a computer server that includes a plurality of server modules, and is positioned in an enclosed room, is disclosed.", "The method includes transferring heat generated by a server module of the plurality of server modules to a hot plate of a liquid cooling system.", "The liquid cooling system may be positioned within the server module, and the hot plate may have a surface exposed to the enclosed room.", "The method may also include positioning a cold plate of a room-level cooling system in thermal contact with the hot plate.", "The method may further include directing a cooling medium through the room-level cooling system to transfer heat from the hot plate to a cooling unit positioned outside the room.", "In another aspect, a method of cooling a computer server including a plurality of server modules is disclosed.", "The method may include maintaining a flow of air within a server module of the plurality of server modules to absorb heat from one or more heat generating devices of the server module.", "The method may also include directing the flow of air through an air-to-liquid heat exchanger of a closed loop liquid cooling system to transfer the absorbed heat to a coolant of the liquid cooling system.", "The liquid cooling system may be positioned within the server module.", "The method may also include directing the coolant to a hot plate of the liquid cooling system.", "The hot plate may be positioned such that at least a heat exchange surface of the hot plate is exposed outside the server module.", "The method may further include transferring heat from the hot plate to a location remote from the computer server using a cooling medium of a second closed loop cooling system positioned outside the server module.", "In yet another aspect, a method of cooling a plurality of computer servers positioned in a server room is disclosed.", "The method may include transferring heat generated by each computer server of the plurality of computer servers to an exterior of the computer server using a closed loop liquid cooling system positioned within the computer server.", "The method may also include thermally coupling a second closed loop cooling system to the liquid cooling system of the computer server.", "The method may also include circulating a cooling medium through the second closed loop cooling system to transfer heat from the liquid cooling system of the computer server to a location outside the server room." ], [ "I.", "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. application Ser.", "No.", "14/741,498, filed Jun.", "17, 2015, which is a continuation of U.S. application Ser.", "No.", "14/275,066, filed on May 12, 2014, now U.S. Pat.", "No.", "9,089,078, which is a continuation of U.S. application Ser.", "No.", "14/186,397, filed on Feb. 21, 2014, now U.S. Pat.", "No.", "8,749,968, which is a continuation of U.S. application Ser.", "No.", "13/215,384, filed on Aug. 23, 2011, now U.S. Pat.", "No.", "8,724,315, which claims priority to U.S.", "Provisional Application No.", "61/377,249, filed on Aug. 26, 2010, each of which are incorporated herein by reference in their entirety.", "II.", "TECHNICAL FIELD The present invention is related generally to systems and methods of cooling heat generating components of a computer server or other systems that operate in an enclosed data processing environment, and computer servers and systems incorporating the cooling system.", "III.", "BACKGROUND Electronic systems, such as, for example, computer systems include several integrated circuit (IC) devices that generate heat during operation.", "For effective operation of the computer system, the temperature of the IC devices have to be maintained within acceptable limits.", "While the problem of heat removal from IC devices is an old one, this problem has increased in recent years due to greater numbers of transistors that are packed into a single IC device while reducing the physical size of the device.", "Increasing number of transistors compacted into a smaller area results in a greater concentration of heat that must be removed from that smaller area.", "Bundling multiple computer systems together, such as, for example, in a server, further aggravates the heat removal problem by increasing the amount of heat that has to be removed from a relatively small area.", "In a typical computer server (“server”), multiple computer server modules (“modules”) are stacked together in a rack or a case to consolidate network resources and minimize floor space.", "Modules which are designed for use in a server configuration are typically characterized by a motherboard comprising heat generating electronic components (such as IC devices) housed in a modular chassis or case, which in turn is mounted together with other similar modules, in a rack, blade cabinet, blade server, or other support structure.", "In practice, multiple servers (each comprising several modules) are typically located in an enclosed space such as a server room or a data center.", "During operation, the electronic components in the individual modules generate heat which must be removed for effective functioning of the server.", "FIG.", "1 illustrates an prior art method used to cool multiple servers (each containing multiple modules) housed in an enclosed environment such as, for example, a server room.", "In such a prior art system, cooling fans are used circulate ambient air from the server room through the multiple modules of a server to absorb heat therefrom.", "In the prior art system, cool air directed into the server room through a cold air plenum is passed through the servers to absorb heat generated by IC devices and other heat generating components therein.", "After absorbing the generated heat, the heated air is exhausted back into the server room.", "This heated air is directed through a warm air plenum to a computer room air conditioning (CRAC) system to cool the air and recirculate it back to the server room through the cold air plenum.", "It is known that a large portion (greater than about 31%) of the energy consumption of a typical server room is used in the operation of the CRAC system, and that significant energy savings and resultant green house gas reduction can be achieved by improving the efficiency of the CRAC system.", "“Data Center Energy Characterization Study Site Report,” February 2001, available at http://hightech.lbl.gov/documents/DATA_CENTERS/DC_Benchmarking/Data_Center_Facility1.pdf; “Energy Consumption of Information Technology Data Centers,” and references cited therein, Iyengar et al., December 2010, available at http://www.electronics-cooling.com/2010/12/energy-consumption-of-information-technology-data-centers/.", "Improving the cooling efficiency of servers housed in a server room thereby enables more efficient utilization and conservation of available energy resources, and green house gas emission reduction.", "The disclosed liquid cooling systems and methods are directed to an energy efficient approach of cooling one or more servers located in an enclosed environment, such as a server room.", "IV.", "SUMMARY OF THE DISCLOSURE In one aspect, a method of cooling a computer server that includes a plurality of server modules, and is positioned in an enclosed room, is disclosed.", "The method includes transferring heat generated by a server module of the plurality of server modules to a hot plate of a liquid cooling system.", "The liquid cooling system may be positioned within the server module, and the hot plate may have a surface exposed to the enclosed room.", "The method may also include positioning a cold plate of a room-level cooling system in thermal contact with the hot plate.", "The method may further include directing a cooling medium through the room-level cooling system to transfer heat from the hot plate to a cooling unit positioned outside the room.", "In another aspect, a method of cooling a computer server including a plurality of server modules is disclosed.", "The method may include maintaining a flow of air within a server module of the plurality of server modules to absorb heat from one or more heat generating devices of the server module.", "The method may also include directing the flow of air through an air-to-liquid heat exchanger of a closed loop liquid cooling system to transfer the absorbed heat to a coolant of the liquid cooling system.", "The liquid cooling system may be positioned within the server module.", "The method may also include directing the coolant to a hot plate of the liquid cooling system.", "The hot plate may be positioned such that at least a heat exchange surface of the hot plate is exposed outside the server module.", "The method may further include transferring heat from the hot plate to a location remote from the computer server using a cooling medium of a second closed loop cooling system positioned outside the server module.", "In yet another aspect, a method of cooling a plurality of computer servers positioned in a server room is disclosed.", "The method may include transferring heat generated by each computer server of the plurality of computer servers to an exterior of the computer server using a closed loop liquid cooling system positioned within the computer server.", "The method may also include thermally coupling a second closed loop cooling system to the liquid cooling system of the computer server.", "The method may also include circulating a cooling medium through the second closed loop cooling system to transfer heat from the liquid cooling system of the computer server to a location outside the server room.", "V. BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates a prior art server room cooling system; FIG.", "2A is an illustration of an exemplary embodiment of the disclosed cooling system applied to a server module; FIG.", "2B is an illustration of another exemplary embodiment of the disclosed cooling system applied to a server module; FIG.", "2C is an illustration of another exemplary embodiment of the disclosed cooling system applied to a server module; FIG.", "3 is a schematic illustrating an exemplary embodiment of the disclosed cooling system; FIG.", "4 is an illustration of an exemplary embodiment of the disclosed cooling system applied to multiple server units; FIG.", "5A is an illustration of an exemplary embodiment of the disclosed cooling system applied to an exemplary server unit; FIG.", "5B is an illustration of another exemplary embodiment of the disclosed cooling system applied to an exemplary server unit; FIG.", "6A is an illustration of an exemplary hot plate used in the disclosed cooling system; and FIG.", "6B is an exploded view of the cold plate of FIG.", "6A.", "VI.", "DETAILED DESCRIPTION The following detailed description illustrates the cooling system by way of example and not by way of limitation.", "Although the description below describes an application of a liquid cooling system to servers housed in an enclosed environment, embodiments of the disclosed cooling systems may be applied to cool heat generating components in any application.", "For example, embodiments of the current disclosure may be used to cool portable computers that operate while being docked to a docking station.", "The description enables one skilled in the art to make and use the present disclosure for cooling any electronic component within a console or a chassis.", "Reference will now be made to exemplary embodiments of the invention, examples of which are illustrated in the accompanying drawings.", "Wherever possible, the same reference numbers will be used throughout the drawings to refer to the same or like parts.", "Elements or parts designated using the same reference numbers in different figures perform similar functions.", "Therefore, for the sake of brevity, these elements may not be described with reference to every figure.", "In the description that follows, if an element is not described with reference to a figure, the description of the element made with reference to another figure applies.", "FIG.", "2A illustrates an exemplary individual computer server unit (or a module 10A) having a modular chassis adapted for placement in a server rack.", "Module 10A includes a motherboard 12 having mounted thereon (or attached thereto, such as, for example, by using a data cable) a plurality of heat generating electronic devices 14.These electronic devices 14 may include, without limitation, any type of IC or other devices (such as, for example, CPUs, GPUs, memory, power supplies, disk drives, controllers, etc.)", "that are found in typical computer systems.", "Module 10A may also include a closed loop liquid cooling system 20 and an air cooling system 30.The air cooling system 30 may include a volume of air 32 circulated within the module 10A by fans 26 or other air moving devices.", "In some embodiments, module 10A may include air directing channels or walls 28 positioned to direct the air flow in a desired pattern within the module 10A.", "Air 32 circulating within the module 10A may remove heat from, and cool, some or all of the electronic devices 14 contained within the module 10A.", "The liquid cooling system 20 of the module 10A may remove the heat from the air 32 and transfer the heat to a liquid coolant (“coolant 22”) circulating within the liquid cooling system 20.The liquid cooling system 20 may include one or more air-to-liquid heat exchangers (HEX 16) for interacting with the circulating internal air 32 and transferring the heat from the air 32 to the coolant 22.The liquid cooling system 20 may also include one or more hot plates 18.Although, for the sake of clarity, only one hot plate 18 is illustrated in FIG.", "2A (and in the other figures), in general the liquid cooling system 20 may have any number of hot plates 18.The coolant 22 may absorb heat from the air 32 at HEX 16 and flow to the hot plate 18.At the hot plate 18, the heated coolant 22 may transfer the heat to the hot plate 18 and get cooled thereby.", "The relatively cooler coolant 22 may then flow back to HEX 16 to absorb more heat from air 32 flowing through the HEX 16 and continue the cycle.", "Conduits 23 may fluidly couple the one or more heat exchangers 16 to the hot plate 18.Although in general, the hot plate 18 may be positioned anywhere in module 10A, in some embodiments, the hot plate 18 may be positioned proximate to, or on, an external surface of the module 10A.", "In embodiments having a plurality of hot plates 18, these hot plates 18 may be positioned proximate the same location or at different locations.", "In some embodiments, all, or a majority of these plurality of hot plates 18 may be positioned proximate to, or on, an external surface of module 10A.", "In some embodiments, the liquid cooling system 20 may also include pumps or other liquid moving devices (not shown) to assist in transferring the coolant 22 between HEX 16 and the hot plate 18.Alternatively, some configurations of the liquid cooling system 20 system may not include a pump, and instead, rely upon the expansion and contraction of the coolant 22 as it absorbs and dissipates heat to propel the coolant 22 between the HEX 16 and the hot plate 18.Any liquid, such as, for example, water, alcohol, mixtures of alcohol and water, etc.", "may be used as coolant 22.Although coolant 22 is described as a liquid, in some embodiments, a phase change material may be used as the coolant 22.In these embodiments, a coolant 22 in a liquid phase may transform to a gaseous phase after absorption of heat at HEX 16.The coolant 22 may transform back to the liquid phase after transferring the absorbed heat to the hot plate 18.In some embodiments, valves or other known fluid control devices (not shown) may be provided in the liquid cooling system 20 to control the flow of the coolant 22 therein.", "Further, it is also contemplated that in some embodiments, the liquid cooling system 20 may be an open loop system instead of a closed loop system.", "In such an embodiment, the heated coolant 22 from the HEX 16 may be replaced with cooler coolant from outside the cooling system.", "FIG.", "2B illustrates another embodiment of a module having an air cooling system 30 and a liquid cooling system 20.Similar to module 10A of FIG.", "2A, module 10B of FIG.", "2B may be configured to transfer heat from air 32 circulating within the module 10B to the coolant 22 circulating within a liquid cooling system 20.In addition to cooling the air 32 within the module 10B, the liquid cooling system 20 of module 10B may also directly cool one or more electronic devices 14 of the module 10B.", "To directly cool an electronic device 14, a cold plate 26 of the liquid cooling system 10 may be placed in thermal contact (directly in contact, or in contact through a heat transfer medium, such as, for example, thermal grease or a thermal pad) with the electronic device 14.Because of thermal contact, heat may be transferred from the electronic device 14 to the cold plate 26.The coolant 22 of the liquid cooling system 20 may pass through the cold plate 26 to remove heat from, and thereby cool, the cold plate 26.Any type of cold plate 26 configured to transfer heat from the electronic device 14 to the coolant 22 circulating within liquid cooling system 20 may be used as the cold plate 26.The cold plate 26 may include fins, pins, or other such features to assist in transferring the heat from the cold plate 26 to the coolant 22.In some embodiments, devices used to transfer heat from heat generating electronic devices to the coolant in co-assigned patent application Ser.", "Nos.", "10/578,578, 11/919,974, 12/826,736, 12/914,190, and 12/914,263, with appropriate modifications, may be used as cold plate 26.These patent applications are incorporated by reference herein in their entirety.", "Although FIG.", "2B illustrates two electronic devices 14 as being directly cooled by the liquid cooling system 20, this is only exemplary.", "In general, any number of electronic devices 14 of module 10B may be directly cooled by the liquid cooling system 20.HEX 16 may be any type of heat exchanger that is configured to transfer heat from hotter air 32 flowing outside HEX 16 to cooler coolant 22 flowing within HEX 16.For instance, in some embodiments, HEX 16 may be a cross-flow, parallel-flow, or a counter-flow heat exchanger that is used to transfer heat from air to liquid circulating within the heat exchanger.", "The air 32 within modules 10A and 10B of FIGS.", "2A and 2B, respectively, may be blown through the HEX 16 using one of more fans 26 positioned within the module.", "Although only a single set of fans 26 is illustrated FIGS.", "2A and 2B, this is only exemplary.", "In general, fans 26 may be positioned at any location within a module to achieve a desired circulation of air within the module.", "Similarly although only one HEX 16 is illustrated in FIGS.", "2A and 2B, any number of heat exchangers may be positioned in a module to achieve a desired temperature distribution in a module.", "FIG.", "2C illustrates an embodiment of a module 10C including two HEXs 16 and two sets of fans 26 positioned in the module 10C.", "In general, the location of the HEXs 16 and the fans 26 may be selected based on the relative amounts of heat generated by the different electronic devices 14 in the module 10C.", "For instance, in some embodiments, a HEX 16 may be positioned proximate (that is, immediately upstream and/or downstream of) a device 14 that produces a relatively large amount of heat.", "Positioning a HEX 16 upstream of such a device 14 may more effectively cool the device 14 by cooling the air 32 used to remove heat from the device 14.And, positioning a HEX 16 immediately downstream of a high heat generating device 14 may cool the air 32 heated by the device 14, and thereby enable more effective cooling of other electronic devices 14 in the module 10C.", "Typically, a set of fans 26 may be positioned upstream of a HEX 16 to drive the air 32 through the HEX 16.However, it is also contemplated that in some embodiments, fans 26 may be positioned downstream of a HEX 16 to pull the air 32 through the HEX 16.With reference to FIG.", "3, in some embodiments, a module (10A, 10B, 10C, collectively module 10) may be sealed to minimize the transfer of air from inside the module to outside the module.", "In such embodiments, free flow of air between the module 10 and the server room 100 may be prevented.", "That is, module 10 may not include passages and other openings that are typically provided in the chassis of a computer system to allow air to flow into and out of the computer system.", "In these embodiments, substantially all the air 32 within the module 10 may stay within the module 10.However, it should be noted that a perfect seal between the module 10 and the server room 100 is not a requirement, and some transfer of air between the module 10 and the server room 100 may be unavoidable due to leaks, gaps between panels of the module chassis, cracks in the panels, etc.", "That is, in an embodiment of the module 10 that is substantially sealed to prevent the flow of air between the server room 100 and the module 10, the module 10 may be substantially free of openings and other passages that permit the free transfer of air between the module 10 and the server room 100.In such a module 10, a majority of heat from the module 10 may be removed by the liquid cooling system 20.The heated air 32 in the module 10 may heat the chassis of the module 10, and some amount of heat transfer may occur as a result of heat transfer from the chassis to the server room, and as a result of leakage of air 32 from the module 10.However, it is expected that a majority of heat from module 10 may be transferred through the liquid cooling system 20.Liquid cooling system 20 may transfer the heat absorbed in module 10 to a second cooling system 40.The second cooling system may be a cooling system that is associated with server room 100 or the enclosed environment within which the modules 10 are located.", "Second cooling system 40 may circulate a thermal transfer medium 42 (any fluid, such as a liquid or a gas) therethrough to absorb heat from the liquid cooling systems 20 associated with different modules 10, and discharge the heat remote from these modules 10.Any type of fluid, such as water, alcohol, mixtures thereof, a gas, etc.", "may be used as thermal transfer medium 42.It is also contemplated that, in some embodiments, a phase change material may be used as the thermal transfer medium 42.In some embodiments, second cooling system 40 may be a closed loop cooling system.", "However, it is contemplated that in other embodiments, the second cooling system 40 may be an open loop system.", "In some embodiments, as illustrated in FIG.", "3, second cooling system 40 may absorb heat from one or modules 10 positioned in the server room 100, and discharge the heat outside the server room 100.The second cooling system 40 may consist of one or more cold plate elements 48, a cooling device 46 disposed external to server room 100, and conduits to transfer the thermal transfer medium 42 between the cooling device 46 and the cold plate elements 48.The thermal transfer medium 42, may be circulated between the cooling device 46 and the cold plate elements 48 of the modules 10 of several servers positioned in the server room.", "The circulating thermal transfer medium 42 may thus draw heat from the hot plates 18 of these modules 10 and discharge the heat external to the server room 100.In some embodiments, pumps and/or other control devices may be provided to assist in directing the thermal transfer medium 42 through the second cooling system 40.Transferring the heat generated by the servers outside the server room 100 avoids heating the air in the server room, and thus reduces the cooling load of the server room cooling system.", "It is also contemplated that the heat removed from the server room by thermal transfer medium 42 may be used to do useful work.", "For instance, this removed heat may be used in an HVAC system to heat a building.", "In a server application, as illustrated in FIG.", "4, several modules 10, having a liquid cooling system 20 and an air cooling system 30 therein, may be mounted on a rack 50 positioned in the server room 100.The server room 100 may include several racks 50 with modules 10 mounted thereon.", "A cold plate 48 associated with the second cooling system 40 may thermally couple to, and remove heat from, the hot plates 18 associated with the liquid cooling system 20 of each of these modules 10.In some embodiments, to assist in thermally coupling the cold plate 48 to the hot plates 18, the hot plates 18 may be positioned proximate to, or on mounted on, the chassis of the modules 10 with a surface exposed to the server room 100.In these embodiments, a surface of the cold plates 48 may be placed in thermal contact with the exposed surface of the hot plates 18 for transfer of heat therebetween.", "In some embodiments, the second cooling system 40 may circulate the thermal transfer medium 42 through the cold plates 48 using one or more pumps 44 to transfer the heat from the hot plates 18 to the cooling device 46 outside the server room 100.The cooling device 46 may be any type of device (such, as a chiller, a heat exchanger, etc.)", "adapted to remove heat from the thermal transfer medium 42 passing therethrough.", "In some embodiments, each module 10 in a rack 50 may include both a liquid cooling system 20 and an air cooling system 30.However, in some embodiments (as illustrated in FIG.", "4), one or more modules 10 of a rack 50 may include only a liquid cooling system 20.In some such embodiments, these one or more modules 10 may include openings or passages that permit transfer of air between the server room 100 and the module 10.That is, in such embodiments, the modules 10 of the rack 50 that do not include an air cooling system 40 may not be substantially sealed from the server room 100.In some embodiments (such as in blade server applications where each module 10 may not be enclosed in a separate chassis), each module 10 of a rack 50 may not be individually sealed from the server room 100.In these embodiments, air 32 may flow between the modules 10 in a rack 50, and the rack 50 may be substantially sealed from the server room 100.Although a particular flow path of the thermal transfer medium 42 is illustrated in FIG.", "4, this is only exemplary.", "In general, the thermal transfer medium 42 may be circulated through the server room 100 in any pattern.", "Further, although FIG.", "4 illustrates each module 10 associated with a rack 50 as having a liquid cooling system 20 therein, this is only exemplary.", "It is contemplated that, in some embodiments, only some of the modules 10 in a rack 50 may include a liquid cooling system 20, and only a selected ones of these modules may thermally couple with the second cooling system 40.In some server applications, in addition to the heat generated in the modules 10, the rack 50 may itself generate heat.", "For instance, in some server applications, the modules 10 in a rack 50 may not include separate power supplies.", "Instead, the power supplies may be located in the rack 50, and the rack 50 may deliver the required power to the modules 10 mounted in the rack 50.In such embodiments, as illustrated in FIG.", "5A, the rack 50 may include a rack-level cooling system 51 with a hot plate 68 that mates with a cold plate 48 of the second cooling system 40.The rack-level cooling system 51 may be a closed loop liquid cooling system that circulates a liquid coolant to remove heat from the electronic devices 14 of the rack 50.Cold plates 26 of the rack-level cooling system 51 may thermally couple with and remove heat from electronic devices 14 of the rack 50, and transfer the heat to the hot plate 68 positioned proximate (or on the chassis with a surface exposed to the server room 100) an external surface of the rack 50.A cold plate 48 of the second cooling system 40 may thermally couple with and remove heat from the hot plate 68 of the rack-level cooling system 51.In some embodiments, as illustrated in FIG.", "5B, in addition to cold plates 26 that remove heat from electronic devices 14 of the rack 50, the rack-level cooling system 51 may include multiple cold plates 58 that thermally couple with the hot plates 18 of the modules 10.In such an embodiment, the rack-level cooling system 51 may remove heat from the modules 10, and transfer the heat to the second cooling system 40 through a hot plate 68 placed in thermal contact with the cold plate 48 of the second cooling system 40.A hot plate (18, 68) and a cold plate (48, 58) may be any component that enables heat transfer between a coolant and a heat exchange surface.", "In some embodiments, a hot plate and a cold plate may be substantially similar components that mate with each to transfer heat therebetween.", "For the sake of brevity, only hot plate 18 of liquid cooling system 20 may be described herein.", "The other hot plates (such as, hot plate 68) and cold plates (48, 58) may be substantially similar in structure to hot plate 18.FIGS.", "6A and 6B illustrate an exemplary embodiment of hot plate 18 that may be used to transfer heat from coolant 22 of the liquid cooling system 20.FIG.", "6A shows a perspective view of the hot plate 18, while FIG.", "6B shows a view with the cover partially removed to show the structure within.", "In the description below, reference will be made to both FIGS.", "6A and 6B.", "The hot plate 18 may include a conductive plate 72 and a cover 74.The conductive plate 72 may be made of any thermally conductive material (such as, for example, copper, aluminum, etc) and the cover 74 may be made of either a conductive or a non-conductive material.", "The cover 74 and the conductive plate 72 may attached together to define a reservoir 76 therebetween.", "The cover 74 may be attached to the conductive plate 72 in any manner, such as, for example, using an adhesive, solder, braze, or by another known mechanism.", "The coolant 22 of the liquid cooling system 20 may circulate through the reservoir 76 to transfer heat from the coolant 22 to the conductive plate 72.The cover 74 may include openings for an inlet 78a and an outlet 78b for reservoir 76.Conduits 22a and 22b couple with the inlet 78a and the outlet 78b to direct the coolant 22 into and out of the reservoir 76.The size of the conductive plate 72 and the reservoir 76 may be selected so that the hot plate 18 can fit within the available space in module 10 while providing the necessary surface area for cooling.", "Conductive plate 72 of hot plate 18 may include a first surface 72a exposed to reservoir 76 and an opposing second surface 72b.", "First surface 72a may include fins 73 that project from the first surface 72a into the reservoir 76.These fins 73 may include multiple plates oriented parallel to each other.", "These fins 73 may be adapted to absorb heat from the coolant 22 that passes through reservoir 76.The fins 73 may function to increase the area of contact of the coolant 22 to the first surface 72a and serve to generate turbulence in the coolant 22 flowing through the reservoir 76.Although the fins 73 are depicted as parallel plates in FIG.", "6B, the fins 73 may alternatively or additionally include other structures (such as pins, etc.).", "Conductive plate 72 may mate with the cover 74 and form a liquid-tight seal.", "The second surface 72b of conductive plate 72 may be thermally coupled to a second surface of a cold plate (such as, for example, cold plates 48 and 58) to transfer heat from the hot plate 18 to the thermally coupled cold plate.", "In some embodiments, the hot plate 18 may be mounted in a module 10 such that the second surface 72b is exposed to the server room 100.In some embodiments, the second surface 72b may be substantially flat while in other embodiments, second surface 72b may include features (such as alignment features) that assist in aligning the hot plate 18 to a cold plate.", "In some embodiments, a thermally coupled hot plate—cold plate pair may include retention features that enable the hot plate to couple with a cold plate efficiently.", "These features may include mating bolt and hole pairs and or other known features.", "In some embodiments, cold plate 18 may include snap-on features that enable the hot plate 18 to snap on to, and thermally couple with a cold plate (such as, cold plate 58 of FIG.", "5B, or cold plate 48 of FIG.", "5A) when a module 10 is slid into a rack 50.In some embodiments, this snap-on feature may be configured to separate and allow the module 10 to be pulled out of rack 50 when a pulling force is applied.", "The disclosed server cooling system in which a liquid cooling system 20 of a module 10 of a server rack 50 mates with and transfers heat to a second cooling system 40 of the server room 100, enables the servers to be cooled without transferring the heat to the server room 100 Since the server room 100 is not heated, the necessity of large CRAC systems are eliminated.", "As discussed in the background section, the electrical power consumed to operate a CRAC system of a server room accounts for a large portion of the total server room power consumption.", "Although the cooling device 46 of the second cooling system 40 consumes power, this power consumption will be significantly less than that necessary to operate the CRAC system.", "Eliminating the need for large CRAC systems to cool the server room 100 thereby reduces power consumption associated with cooling the server room.", "This reduction in power consumption enables more efficient utilization and conservation of available energy resources, and concomitant reduction in green house gas emissions.", "Since additional modules 10 can be added to a server rack 50 without breeching a liquid cooling system, the danger of liquid spillage within a server is also eliminated.", "It will be apparent to those skilled in the art that various modifications and variations can be made to the disclosed cooling systems.", "Other embodiments will be apparent to those skilled in the art from consideration of the specification and practice of the disclosed cooling systems.", "It is intended that the specification and examples be considered as exemplary only, with a true scope being indicated by the following claims and their equivalents." ] ]
Patent_15872524
[ [ "SPINAL IMPLANT SYSTEM AND METHOD", "A spinal implant comprises an implant body extending between an anterior surface and a posterior surface, and including a first vertebral engaging surface and a second vertebral engaging surface.", "The implant body includes an inner surface that defines at least one opening oriented to implant a fastener oblique relative to a lateral axis of a subject body and adjacent an intervertebral space of the subject body.", "The implant body defining a cavity such that a surgical instrument is connectable with the implant body adjacent the cavity and movable relative to the implant body.", "Systems, surgical instruments and methods are disclosed." ], [ "1-20.", "(canceled) 21.A spinal implant comprising: an implant body comprising opposite first and second side surfaces, opposite first and second end surfaces that each extend from the first side surface to the second side surface, and opposite first and second vertebral engaging surfaces that each extend from the first side surface to the second side surface and from the first end surface to the second end surface, the implant body defining an opening that extends through the first side surface and at least one of the vertebral engaging surfaces, the first end surface defining a cavity; and a member movably disposed in the cavity, the member being connectable with a surgical instrument to connect the surgical instrument with the implant body.", "22.A spinal implant as recited in claim 21, wherein the opening extends through the first vertebral engaging surface and the second vertebral engagement surface.", "23.A spinal implant as recited in claim 21, wherein the implant body includes an aperture that extends through the first vertebral engaging surface and the second vertebral engagement surface, the opening being in communication with the opening.", "24.A spinal implant as recited in claim 21, wherein the implant body includes a first hole that extends through the first side surface and a second hole that extends through the second side surface.", "25.A spinal implant as recited in claim 24, wherein the implant body includes an aperture that extends through the first vertebral engaging surface and the second vertebral engagement surface, the holes each being in communication with the opening.", "26.A spinal implant as recited in claim 24, wherein the first hole is coaxial with the second hole.", "27.A spinal implant as recited in claim 21, wherein the first vertebral engaging surface defines a track that is in communication with the cavity, the member being slidably engageable with the track.", "28.A spinal implant as recited in claim 21, wherein the first vertebral engaging surface defines a track that is in communication with the cavity, the member being movable along the track.", "29.A spinal implant as recited in claim 21, wherein the cavity is defined by an inner surface of the implant body, the inner surface including first end and a second end that define a range of movement in the cavity.", "30.A spinal implant as recited in claim 21, further comprising the surgical instrument, wherein the member comprises a socket configured for disposal of an end of the surgical instrument.", "31.A spinal implant as recited in claim 21, further comprising the surgical instrument, wherein the surgical instrument comprises a threaded outer surface that mates with a threaded inner surface of the member to connect the surgical instrument with the member.", "32.A spinal implant as recited in claim 21, wherein the second end surface defines a bullet nose of the implant body.", "33.A spinal implant comprising: an implant body comprising opposite first and second side surfaces, opposite first and second end surfaces that each extend from the first side surface to the second side surface, and opposite first and second vertebral engaging surfaces that each extend from the first side surface to the second side surface and from the first end surface to the second end surface, the implant body defining an aperture that extends through the first and second vertebral engaging surfaces, the implant body defining an opening that extends through the first side surface and the first vertebral engaging surface, the opening being in communication with the aperture, the first end surface defining a cavity; and a member movably disposed in the cavity, the member being connectable with a surgical instrument to connect the surgical instrument with the implant body.", "34.A spinal implant as recited in claim 33, wherein the first vertebral engaging surface defines a track that is in communication with the cavity, the member being slidably engageable with the track.", "35.A spinal implant as recited in claim 33, wherein the first vertebral engaging surface defines a track that is in communication with the cavity, the member being movable along the track.", "36.A spinal implant as recited in claim 33, wherein the cavity is defined by an inner surface of the implant body, the inner surface including first end and a second end that define a range of movement in the cavity.", "37.A spinal implant as recited in claim 33, further comprising the surgical instrument, wherein the member comprises a socket configured for disposal of an end of the surgical instrument.", "38.A spinal implant as recited in claim 33, further comprising the surgical instrument, wherein the surgical instrument comprises a threaded outer surface that mates with a threaded inner surface of the member to connect the surgical instrument with the member.", "39.A spinal implant as recited in claim 33, wherein the second end surface defines a bullet nose of the implant body.", "40.A spinal implant comprising: an implant body comprising opposite first and second side surfaces, opposite first and second end surfaces that each extend from the first side surface to the second side surface, and opposite first and second vertebral engaging surfaces that each extend from the first side surface to the second side surface and from the first end surface to the second end surface, the implant body defining an aperture that extends through the first and second vertebral engaging surfaces, the implant body defining an opening that extends through the first side surface and the first vertebral engaging surface, the opening being in communication with the aperture, the first end surface defining a cavity, the first vertebral engaging surface defining a track that is in communication with the cavity; a member movably disposed in the cavity and slidably engageable with the track, the member comprising a threaded inner surface; a surgical instrument comprising a threaded outer surface that mates with the threaded inner surface to connect the surgical instrument with the member." ], [ "<SOH> BACKGROUND <EOH>Spinal pathologies and disorders such as degenerative disc disease, disc herniation, spondylolisthesis, stenosis, osteoporosis, tumor, scoliosis and other curvature abnormalities, kyphosis and fracture may result from factors including trauma, disease and degenerative conditions caused by injury and aging.", "Spinal disorders typically result in symptoms including deformity, pain, nerve damage, and partial or complete loss of mobility.", "Non-surgical treatments, such as medication, rehabilitation and exercise can be effective, however, may fail to relieve the symptoms associated with these disorders.", "Surgical treatment of these spinal disorders includes fusion, fixation, correction, discectomy, microdiscectomy, corpectomy, decompression, laminectomy, laminotomy, foraminotomy, facetectomy and implantable prosthetics.", "As part of these surgical treatments, spinal constructs, such as, for example, bone fasteners, spinal rods and interbody devices can be used to provide stability to a treated region.", "For example, during surgical treatment, surgical instruments can be used to deliver components of the spinal constructs to the surgical site for fixation with bone to immobilize a joint.", "Certain spinal surgery approaches utilize a direct lateral approach to access intervertebral spaces, however, these techniques present certain challenges due to the location of musculature and neural structures embedded therein.", "This disclosure describes an improvement over these prior technologies." ], [ "<SOH> SUMMARY <EOH>In one embodiment, a spinal implant comprises an implant body extending between an anterior surface and a posterior surface, and including a first vertebral engaging surface and a second vertebral engaging surface.", "The implant body includes an inner surface that defines at least one opening oriented to implant a fastener oblique relative to a lateral axis of a subject body and adjacent an intervertebral space of the subject body.", "The implant body defining a cavity such that a surgical instrument is connectable with the implant body adjacent the cavity and movable relative to the implant body.", "In some embodiments, systems, surgical instruments and methods are provided." ], [ "TECHNICAL FIELD The present disclosure generally relates to medical devices for the treatment of musculoskeletal disorders, and more particularly to a spinal implant system and a method for treating a spine.", "BACKGROUND Spinal pathologies and disorders such as degenerative disc disease, disc herniation, spondylolisthesis, stenosis, osteoporosis, tumor, scoliosis and other curvature abnormalities, kyphosis and fracture may result from factors including trauma, disease and degenerative conditions caused by injury and aging.", "Spinal disorders typically result in symptoms including deformity, pain, nerve damage, and partial or complete loss of mobility.", "Non-surgical treatments, such as medication, rehabilitation and exercise can be effective, however, may fail to relieve the symptoms associated with these disorders.", "Surgical treatment of these spinal disorders includes fusion, fixation, correction, discectomy, microdiscectomy, corpectomy, decompression, laminectomy, laminotomy, foraminotomy, facetectomy and implantable prosthetics.", "As part of these surgical treatments, spinal constructs, such as, for example, bone fasteners, spinal rods and interbody devices can be used to provide stability to a treated region.", "For example, during surgical treatment, surgical instruments can be used to deliver components of the spinal constructs to the surgical site for fixation with bone to immobilize a joint.", "Certain spinal surgery approaches utilize a direct lateral approach to access intervertebral spaces, however, these techniques present certain challenges due to the location of musculature and neural structures embedded therein.", "This disclosure describes an improvement over these prior technologies.", "SUMMARY In one embodiment, a spinal implant comprises an implant body extending between an anterior surface and a posterior surface, and including a first vertebral engaging surface and a second vertebral engaging surface.", "The implant body includes an inner surface that defines at least one opening oriented to implant a fastener oblique relative to a lateral axis of a subject body and adjacent an intervertebral space of the subject body.", "The implant body defining a cavity such that a surgical instrument is connectable with the implant body adjacent the cavity and movable relative to the implant body.", "In some embodiments, systems, surgical instruments and methods are provided.", "BRIEF DESCRIPTION OF THE DRAWINGS The present disclosure will become more readily apparent from the specific description accompanied by the following drawings, in which: FIG.", "1 is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure; FIG.", "2 is a perspective view of the components shown in FIG.", "1; FIG.", "3 is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure; FIG.", "4 is a perspective view of the components shown in FIG.", "3; FIG.", "5 is a side view of vertebrae; FIG.", "6 is a side view of vertebrae; FIG.", "7 is a perspective view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure disposed with vertebrae; FIG.", "8 is an axial view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure disposed with vertebrae; FIG.", "9 is an axial view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure disposed with vertebrae; FIG.", "10 is a side view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure disposed with vertebrae; FIG.", "11 is a side view, in part phantom, of components of one embodiment of a surgical system in accordance with the principles of the present disclosure disposed with vertebrae; FIG.", "12 is a side view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure disposed with vertebrae; FIG.", "13 is a plan view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure disposed with vertebrae; FIG.", "14 is a side view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure disposed with vertebrae; FIG.", "15 is a side view of components of one embodiment of a surgical system in accordance with the principles of the present disclosure disposed with vertebrae; and FIG.", "16 is a side view, in part phantom, of components of one embodiment of a system in accordance with the principles of the present disclosure disposed with vertebrae.", "DETAILED DESCRIPTION The exemplary embodiments of the surgical system and related methods of use disclosed are discussed in terms of medical devices for the treatment of musculoskeletal disorders and more particularly, in terms of a surgical system for implant delivery to a surgical site and a method for treating a spine.", "In some embodiments, the systems and methods of the present disclosure employ an oblique surgical pathway, which may include an oblique-lateral surgical pathway.", "In some embodiments, the systems and methods of the present disclosure are employed with a spinal joint and fusion, for example, with a cervical, thoracic, lumbar and/or sacral region of a spine.", "In some embodiments, the surgical system includes an interbody implant configured as a stand-alone device.", "In some embodiments, the interbody implant can be employed with a method for lordotic correction.", "In some embodiments, the interbody implant is configured for insertion along an oblique pathway.", "In some embodiments, the interbody implant includes an oblique opening, such as, for example, a screw hole configured for disposal of a bone screw.", "In some embodiments, the oblique opening is configured to facilitate fixation of a bone fastener obliquely into and through the interbody implant and into an adjacent vertebral body endplate.", "In some embodiments, the surgical system is employed with a method for treating a spine that includes the step of creating additional lordosis using the interbody implant.", "In some embodiments, the interbody implant includes an oblique lateral shape.", "In some embodiments, the interbody implant includes a slidable inserter aperture.", "In some embodiments, the surgical system includes an interbody implant employed with a method of anterior posterior lordotic correction of vertebrae.", "In some embodiments, the method includes the step of treating vertebrae including a first vertebral surface and a second vertebral surface, the vertebral surfaces being disposed at a relative lordotic angle of approximately 5 angular degrees.", "In some embodiments, the method includes the step of removing vertebral tissue from between and/or including the vertebral surfaces.", "In some embodiments, the vertebrae defines a disc space between the vertebral surfaces and the method includes the step of inserting an interbody implant into the disc space.", "In some embodiments, the method includes the step of aligning an upper surface of the interbody implant into a flush orientation with a first vertebral surface.", "In some embodiments, the method includes the step of inserting a bone fastener through the interbody implant and into the first vertebral surface to lock the interbody implant into position with the vertebrae such that an angular gap is defined between the interbody implant and a second vertebral surface.", "In some embodiments, the method includes the step of removing posterior bone to facilitate angular correction.", "In some embodiments, the method includes the step of removing facet joints.", "In some embodiments, the method includes the step of removing a portion of a lamina.", "In some embodiments, the method includes the step of removing a portion of a spinous process.", "In some embodiments, the method includes the step of manipulating the vertebral surfaces to reduce and/or rotate the vertebral surfaces such that a lower surface of the interbody implant is flush with the second vertebral surface.", "In some embodiments, the method includes the step of manipulating the vertebral surfaces to a relative lordotic angle of approximately 20 angular degrees.", "In some embodiments, the step of manipulating includes utilizing instruments, external manipulation or posterior fixation devices, such as, for example, pedicle screws, to reduce and/or rotate the vertebral surfaces.", "In some embodiments, the method includes the step of locking the vertebral surfaces at a relative lordotic angle orientation with posterior implants, such as, for example, bi-lateral pedicle screws and spinal rods.", "In some embodiments, the surgical system includes an interbody implant employed with a method that includes an oblique lateral interbody fusion (OLIF) procedure.", "In some embodiments, the surgical system includes a surgical instrument, such as, for example, an inserter configured for connection with an interbody implant.", "In some embodiments, the inserter can be attached with the interbody implant in-line, at various oblique angles and/or modified inter-operatively.", "In some embodiments, the interbody implant is configured for connection with a single bone fastener.", "In some embodiments, the interbody implant is configured for connection with multiple bone fasteners.", "In some embodiments, the multiple bone fasteners are configured for fixation with only one vertebral endplate.", "In some embodiments, the surgical system includes an interbody implant employed with a method of treating a spine, which includes the step of inserting the interbody implant into a patient when a patient is disposed in a lateral position with the left side up and the bone fastener is connected with a superior vertebral endplate.", "In some embodiments, the surgical system includes an interbody implant employed with a method of treating a spine, which includes the step of inserting the interbody implant into a patient when a patient is disposed in a lateral position with the right side up and the bone fastener is connected with an inferior vertebral endplate.", "In some embodiments, the surgical system includes an interbody implant employed with a method of treating a spine, which includes the step of inserting the interbody implant into a patient when a patient is disposed in a lateral position with the left side up and the bone fastener is connected with an inferior vertebral endplate.", "In some embodiments, the surgical system includes an interbody implant employed with a method of treating a spine, which includes the step of inserting the interbody implant into a patient when a patient is disposed in a lateral position with the right side up and the bone fastener is connected with a superior vertebral endplate.", "In some embodiments, the surgical system includes an interbody implant employed with a method of treating a spine, which includes the step of providing posterior fixation with pedicle screws and spinal rods.", "In some embodiments, posterior fixation can include other implants, such as, for example, facet screws and/or spinous process plates.", "In some embodiments, the surgical system includes an interbody implant employed with a method of treating a spine, which includes the step of providing an interbody implant having one or more openings configured for disposal of bone fasteners for connection with vertebrae having a first vertebral surface, such as, for example, a first vertebral endplate and a second vertebral surface, such as, for example, a second vertebral endplate.", "In some embodiments, the method includes the step of fixing the interbody implant with the first vertebral endplate from a lateral approach or an anterior approach.", "In some embodiments, the method includes the step of manipulating the vertebrae for posterior correction via a posterior approach with or without permanent posterior fixation attached.", "In some embodiments, the method includes the step of fixing the interbody implant with the second vertebral endplate from a lateral or anterior approach.", "In some embodiments, the surgical system is used with surgical navigation, such as, for example, fluoroscope or image guidance.", "In some embodiments, one or all of the components of the surgical system are disposable, peel-pack, pre-packed sterile devices.", "One or all of the components of the surgical system may be reusable.", "The surgical system may be configured as a kit with multiple sized and configured components.", "In some embodiments, the present disclosure may be employed to treat spinal disorders such as, for example, degenerative disc disease, disc herniation, osteoporosis, spondylolisthesis, stenosis, scoliosis and other curvature abnormalities, kyphosis, tumor and fractures.", "In some embodiments, the present disclosure may be employed with other osteal and bone related applications, including those associated with diagnostics and therapeutics.", "The present disclosure may also be alternatively employed with procedures for treating the lumbar, cervical, thoracic, sacral and pelvic regions of a spinal column.", "The system and methods of the present disclosure may also be used on animals, bone models and other non-living substrates, such as, for example, in training, testing and demonstration.", "The present disclosure may be understood more readily by reference to the following detailed description of the embodiments taken in connection with the accompanying drawing figures, which form a part of this disclosure.", "It is to be understood that this application is not limited to the specific devices, methods, conditions or parameters described and/or shown herein, and that the terminology used herein is for the purpose of describing particular embodiments by way of example only and is not intended to be limiting.", "In some embodiments, as used in the specification and including the appended claims, the singular forms “a,” “an,” and “the” include the plural, and reference to a particular numerical value includes at least that particular value, unless the context clearly dictates otherwise.", "Ranges may be expressed herein as from “about” or “approximately” one particular value and/or to “about” or “approximately” another particular value.", "When such a range is expressed, another embodiment includes from the one particular value and/or to the other particular value.", "Similarly, when values are expressed as approximations, by use of the antecedent “about,” it will be understood that the particular value forms another embodiment.", "It is also understood that all spatial references, such as, for example, horizontal, vertical, top, upper, lower, bottom, left and right, are for illustrative purposes only and can be varied within the scope of the disclosure.", "For example, the references “upper” and “lower” are relative and used only in the context to the other, and are not necessarily “superior” and “inferior”.", "As used in the specification and including the appended claims, “treating” or “treatment” of a disease or condition refers to performing a procedure that may include administering one or more drugs to a patient (human, normal or otherwise or other mammal), employing implantable devices, and/or employing instruments that treat the disease, such as, for example, microdiscectomy instruments used to remove portions bulging or herniated discs and/or bone spurs, in an effort to alleviate signs or symptoms of the disease or condition.", "Alleviation can occur prior to signs or symptoms of the disease or condition appearing, as well as after their appearance.", "Thus, treating or treatment includes preventing or prevention of disease or undesirable condition (e.g., preventing the disease from occurring in a patient, who may be predisposed to the disease but has not yet been diagnosed as having it).", "In addition, treating or treatment does not require complete alleviation of signs or symptoms, does not require a cure, and specifically includes procedures that have only a marginal effect on the patient.", "Treatment can include inhibiting the disease, e.g., arresting its development, or relieving the disease, e.g., causing regression of the disease.", "For example, treatment can include reducing acute or chronic inflammation; alleviating pain and mitigating and inducing re-growth of new ligament, bone and other tissues; as an adjunct in surgery; and/or any repair procedure.", "As used in the specification and including the appended claims, the term “tissue” includes soft tissue, ligaments, tendons, cartilage and/or bone unless specifically referred to otherwise.", "The following discussion includes a description of a surgical system and related methods of employing the surgical system in accordance with the principles of the present disclosure.", "Alternate embodiments are also disclosed.", "Reference is made in detail to the exemplary embodiments of the present disclosure, which are illustrated in the accompanying figures.", "Turning to FIGS.", "1 and 2, there are illustrated components of a surgical system, for example, a spinal implant system 10.The components of spinal implant system 10 can be fabricated from biologically acceptable materials suitable for medical applications, including metals, synthetic polymers, ceramics and bone material and/or their composites.", "For example, the components of spinal implant system 10, individually or collectively, can be fabricated from materials such as stainless steel alloys, commercially pure titanium, titanium alloys, Grade 5 titanium, super-elastic titanium alloys, cobalt-chrome alloys, superelastic metallic alloys (e.g., Nitinol, super elasto-plastic metals, such as GUM METAL®), ceramics and composites thereof such as calcium phosphate (e.g., SKELITE™), thermoplastics such as polyaryletherketone (PAEK) including polyetheretherketone (PEEK), polyetherketoneketone (PEKK) and polyetherketone (PEK), carbon-PEEK composites, PEEK-BaSO4 polymeric rubbers, polyethylene terephthalate (PET), fabric, silicone, polyurethane, silicone-polyurethane copolymers, polymeric rubbers, polyolefin rubbers, hydrogels, semi-rigid and rigid materials, elastomers, rubbers, thermoplastic elastomers, thermoset elastomers, elastomeric composites, rigid polymers including polyphenylene, polyamide, polyimide, polyetherimide, polyethylene, epoxy, bone material including autograft, allograft, xenograft or transgenic cortical and/or corticocancellous bone, and tissue growth or differentiation factors, partially resorbable materials, such as, for example, composites of metals and calcium-based ceramics, composites of PEEK and calcium based ceramics, composites of PEEK with resorbable polymers, totally resorbable materials, such as, for example, calcium based ceramics such as calcium phosphate such as hydroxyapatite (HA), corraline HA, biphasic calcium phosphate, tricalcium phosphate, or fluorapatite, tri-calcium phosphate (TCP), HA-TCP, calcium sulfate, or other resorbable polymers such as polyaetide, polyglycolide, polytyrosine carbonate, polycaroplaetohe and their combinations, biocompatible ceramics, mineralized collagen, bioactive glasses, porous metals, bone particles, bone fibers, morselized bone chips, bone morphogenetic proteins (BMP), such as BMP-2, BMP-4, BMP-7, rhBMP-2, or rhBMP-7, demineralized bone matrix (DBM), transforming growth factors (TGF, e.g., TGF-β), osteoblast cells, growth and differentiation factor (GDF), insulin-like growth factor 1, platelet-derived growth factor, fibroblast growth factor, or any combination thereof.", "Various components of spinal implant system 10 may have material composites, including the above materials, to achieve various desired characteristics such as strength, rigidity, elasticity, compliance, biomechanical performance, durability and radiolucency or imaging preference.", "The components of spinal implant system 10, individually or collectively, may also be fabricated from a heterogeneous material such as a combination of two or more of the above-described materials.", "The components of spinal implant system 10 may be monolithically formed, integrally connected or include fastening elements and/or instruments, as described herein.", "Spinal implant system 10 is employed, for example, with a fully open surgical procedure, a minimally invasive procedure, including percutaneous techniques, and mini-open surgical techniques to deliver and introduce instrumentation and/or an implant, such as, for example, an interbody implant, at a surgical site of a patient, which includes, for example, a spine having vertebrae V, as shown in FIGS.", "5-16.In some embodiments, a surgical pathway P to a surgical site is formed via an OLIF or DLIF procedure.", "In some embodiments, the implant can include spinal constructs, such as, for example, bone fasteners, spinal rods, connectors and/or plates.", "Spinal implant system 10 includes an implant body, such as, for example, an interbody cage 12, as shown in FIGS.", "1 and 2.Cage 12 extends between a posterior surface 14 and an anterior surface 16 and defines an axis L1.Posterior surface 14 is configured to face a posterior side of a subject body B (FIG.", "8) and be disposed adjacent an posterior portion of vertebrae, such as, for example a posterior portion P1 of one or more intervertebral spaces of vertebrae V (FIG.", "8).", "Anterior surface 16 is configured to face an anterior side of subject body B and be disposed adjacent an anterior portion of vertebrae, such as, for example an anterior portion A1 of one or more intervertebral spaces of vertebrae V (FIG.", "8).", "In some embodiments, cage 12 includes a convex distal end, such as, for example, a bullet nose 18 to facilitate insertion by a surgeon.", "In some embodiments, cage 12 may include chamfers, such as, for example, cut outs 20a, 20b disposed on bullet nose 18 such that cage 12 may be placed in an intervertebral space to avoid impinging on various structures in or near vertebral tissue, such as, for example, a spinal foramina.", "In some embodiments, cage 12 includes any number and configuration of radiopaque markers (such as tantalum pins (not shown)) for visualizing a position of cage 12 using fluoroscopy during insertion, manipulation and implantation.", "In some embodiments, the markers may be placed obliquely on bullet nose 18, in sidewalls of cage 12 adjacent surfaces 14, 16 and/or in a proximal end of cage 12.In some embodiments, the markers may be placed parallel, oblique to and/or perpendicular to surfaces 14, 16 as required to properly visualize the position of cage 12 relative to a surgical pathway P and/or relative to an oblique axis O (FIG.", "8) to facilitate placement of cage 12, as described herein.", "Cage 12 includes a vertebral engaging surface 22 and a vertebral engaging surface 24.Surface 22 may be substantially planar and configured to engage endplate tissue of a vertebral body, such as, for example, an endplate E1 of a vertebral level V1 (FIG.", "10).", "Surface 24 may be substantially planar and configured to engage endplate tissue of a vertebral body, such as, for example, an endplate E2 of a vertebral level V2 (FIG.", "14).", "In some embodiments, surface 22 and/or surface 24 may be rough, textured, porous, semi-porous, dimpled, knurled, toothed, grooved and/or polished to facilitate engagement with tissue.", "In some embodiments, surface 22 and/or surface 24 may be partially convex along axis L1 and/or at least partially convex in a direction substantially perpendicular to an axis L2 (i.e., from surface 16 to surface 14).", "In some embodiments, surface 22 and/or surface 24 may be angled along axis L1 or angled perpendicular to axis L1 such that anterior surface 16 is taller than posterior surface 14 such that cage 12 may be capable of creating and/or augmenting lateral or lordotic curvature in a spine when implanted.", "In some embodiments, vertebral tissue includes intervertebral tissue, endplate surfaces and/or cortical bone.", "In some embodiments, surface 22 and/or surface 24 may be coated with materials suitable for facilitating or encouraging bony ongrowth or fusion including but not limited to titanium and HA coatings.", "In some embodiments, a titanium coating is applied to surface 22 and/or surface 24 in a porous layer using plasma spray technology.", "Cage 12 has a substantially rectangular configuration and includes an inner surface 26 and an outer surface 28.Surface 26 defines an opening 30 configured to receive an agent, which may include bone graft (not shown) and/or other materials, as described herein, for employment in a fixation or fusion treatment.", "In some embodiments, a plan geometry of cage 12 may have various configurations, such as, for example, oval, round, cylindrical, oblong, triangular, rectangular, polygonal having planar or arcuate side portions, irregular, uniform, non-uniform, consistent, variable, horseshoe shape, U-shape or kidney bean shape.", "Cage 12 includes a surface 27 that defines an opening, such as, for example, a screw hole 42.Screw hole 42 extends through cage 12 in a transverse configuration relative to surfaces 22, 24, as described herein, for fixation with tissue.", "In some embodiments, surface 27 defines a fastener opening that is substantially smooth.", "In some embodiments, surface 27 defines one or a plurality of openings, each configured for disposal of a fastener.", "Screw hole 42 defines an axis X1 oriented oblique relative to axis L1.Axis X1 is disposed at an oblique angle α1 relative to axis L1, as shown in FIG.", "2.In some embodiments, angle α1 is in a range of approximately 0-60 degrees.", "In some embodiments, cage 12 is selectively disposed with vertebral tissue, as described herein, such that screw hole 42 is substantially aligned with an oblique surgical pathway P formed in subject body B, as shown in FIG.", "8 and as described herein.", "For example, a surgical pathway P, as shown in FIG.", "8, can be oriented oblique relative to a lateral axis XL of subject body B.", "In some embodiments, surgical pathway P is disposed at an oblique angle α relative to axis XL.", "In some embodiments, angle α is in a range of approximately 0-60 degrees.", "In some embodiments, substantial alignment of all or only a portion of screw hole 42 with all or only a portion of surgical pathway P includes co-axial, spaced apart, offset, angularly offset and/or parallel alignment.", "In some embodiments, axis X1 is oriented oblique relative to axis XL such that screw hole 42 implants a spinal implant, such as, for example, a bone fastener 90, as described herein, oblique relative to axis XL.", "In some embodiments, axis XL lies in a coronal plane CP defined by subject body B.", "In some embodiments, cage 12 is selectively disposed with vertebral tissue, as described herein, such that screw hole 42 is substantially aligned with an oblique surgical pathway P relative to axis XL at an oblique angle α, which is equivalent to angle α1.In some embodiments, angle α is oriented approximately 0-60 degrees relative to axis XL such that bone fastener 90 is delivered via surgical pathway P to screw hole 42.In some embodiments, screw hole 42 is disposed at an angular orientation relative to plane CP and/or axis XL such that bone fastener 90 is delivered to a surgical site including an intervertebral space of one or more of the L2-L5 vertebral levels via surgical pathway P and oriented to penetrate endplate tissue of a vertebral body, such as, for example, endplate E1.In some embodiments, screw hole 42 and/or cage 12 may be disposed at an angular orientation relative to plane CP and/or axis XL such that bone fastener 90 is oriented to penetrate endplate tissue of a vertebral body.", "Surface 28 includes an oblique surface 44 that defines a cavity, such as, for example, a counter bore 46 disposed in communication and alignment with screw hole 42.Oblique surface 44 is oriented with cage 12 and in substantial alignment with axis X1.In some embodiments, counter bore 46 is configured to guide bone fastener 90 into screw hole 42 relative to axis XL and in substantial alignment with surgical pathway P. In some embodiments, surface 44 and/or counter bore 46 includes a countersunk for disposal of a head of bone fastener 90.Cage 12 includes a surface 49 that defines a cavity, such as, for example, an elongated opening 50.Surface 49 includes a track 52 that extends within opening 50 and is configured for engagement with a member 54.The portions of surface 49 that define opening 50 include walls configured to retain member 54 with cage 12 for slidable movement of member 54 relative to cage 12.Track 52 is disposed with opening 50 to define a track pathway 56 that facilitates translation of member 54 therein.", "Track pathway 56 extends substantially along axis L2 and transverse to axis L1.Track pathway 56 includes a limit, such as, for example, a lateral limit 58 and a limit, such as, for example, an oblique limit 60.Limits 58, 60 provide a range of translation of member 54 relative to cage 12 along track pathway 56, as described herein.", "Member 54 is slidably engageable with track 52 for translation relative to cage 12 along track pathway 56.In some embodiments, member 54 is movable along track pathway 56 for translation substantially along axis L2 and/or transverse to axis L1.In some embodiments, member 54 is movable along track pathway 56 for rotation about axis L2 and/or axis L1.In some embodiments, track pathway 56 includes an arcuate configuration.", "In some embodiments, track pathway 56 extends along an arcuate configuration that is substantially concentric with track 52 and/or a lateral surface of cage 12.In some embodiments, track 52, surface 44 and/or track pathway 56 may be arcuate with a single radius defining an arcuate configuration.", "In some embodiments, track 52, surface 44 and/or track pathway 56 may be arcuate with multiple radii defining one or more portions of an arcuate configuration.", "In some embodiments, track 52, surface 44 and/or track pathway 56 may extend along a pathway having various configurations corresponding to an overall shape of cage 12, such as, for example, round, cylindrical, oblong, triangular, rectangular, polygonal having planar or arcuate side portions, irregular, uniform, non-uniform, consistent, variable, horseshoe shape, U-shape or kidney bean shape.", "In some embodiments, surface 49 may be rough, textured, porous, semi-porous, dimpled, knurled, toothed, grooved and/or polished for selective translation of member 54.In some embodiments, as shown in FIGS.", "3 and 4, member 54 is retained with cage 12, as described herein, and configured for mating engagement with a surgical instrument, such as, for example, an inserter 70 described herein, to deliver cage 12 adjacent a surgical site via surgical pathway P, as described herein.", "For example, member 54 is configured to connect inserter 70 with cage 12 via opening 50 disposed with a lateral surface of cage 12.Member 54 includes a connecting surface 76 that defines a socket 78.Socket 78 is configured for releasable engagement with a portion 80 of inserter 70.In some embodiments, member 54 is freely translatable in situ within subject body B.", "In some embodiments, member 54 is positioned within subject body B and locked into a fixed position with inserter 70.In some embodiments, socket 78 and portion 80 can be configured for threaded engagement.", "In some embodiments, inserter 70 is connected with member 54 and member 54 is translatable along track 52 and track pathway 56 relative to subject body B and/or cage 12 to provide selective positioning of cage 12 with respect to a patient's body for adapting to the configuration of the tissue surfaces of vertebrae.", "In some embodiments, oblique axis O (FIG.", "8) includes any axis extending outward from an oblique surface (for example, surface 44 described herein) of cage 12 between lateral limit 58 and oblique limit 60, including but not limited to axes that are co-axial with axis L1 and/or an axis defined by surgical pathway P. Spinal implant system 10 includes one or more bone fasteners 90 depending on the configuration of cage 12.In some embodiments, one or more of bone fasteners 90 may comprise mufti-axial screws, sagittal angulation screws, pedicle screws, mono-axial screws, uni-planar screws, facet screws, fixed screws, tissue penetrating screws, conventional screws, expanding screws, wedges, anchors, buttons, dips, snaps, friction fittings, compressive fittings, expanding rivets, staples, nails, adhesives, posts, fixation plates and/or posts.", "Bone fastener 90 includes a portion, such as, for example, a head 92 and a portion, such as, for example, an elongated shaft 94 configured for penetrating tissue.", "Head 92 includes an engagement portion configured for engagement with a surgical instrument.", "Shaft 94 has a cylindrical cross section configuration and includes an outer surface having an external thread form.", "In some embodiments, the external thread form may include a single thread turn or a plurality of discrete threads.", "In some embodiments, other engaging structures may be located on shaft 94, such as, for example, a nail configuration, barbs, expanding elements, raised elements and/or spikes to facilitate engagement of shaft 94 with tissue, such as, for example, vertebrae.", "In some embodiments, all or only a portion of shaft 94 may have alternate cross section configurations, such as, for example, oval, oblong, triangular, square, polygonal, irregular, uniform, non-uniform, offset, staggered, undulating, arcuate, variable and/or tapered.", "In some embodiments, the outer surface of shaft 94 may include one or a plurality of openings.", "In some embodiments, all or only a portion of the outer surface of shaft 94 may have alternate surface configurations, such as, for example, smooth and/or surface configurations to enhance fixation with tissue, such as, for example, rough, arcuate, undulating, porous, semi-porous, dimpled, polished and/or textured.", "In some embodiments, all or only a portion of shaft 94 may be cannulated.", "In some embodiments, spinal implant system 10 may comprise various surgical instruments, such as, for example, drivers, extenders, reducers, spreaders, distractors, blades, damps, forceps, elevators and drills, which may be alternately sized and dimensioned, and arranged as a kit.", "In some embodiments, spinal implant system 10 may comprise the use of microsurgical and image guided technologies, such as, for example, surgical navigation components employing emitters and sensors, which may be employed to track introduction and/or delivery of the components of spinal implant system 10 including the surgical instruments to a surgical site.", "See, for example, the surgical navigation components and their use as described in U.S. Pat.", "Nos.", "6,021,343, 6,725,080, 6,796,988, the entire contents of each of these references being incorporated by reference herein.", "In assembly, operation and use, as shown in FIGS.", "5-16, spinal implant system 10, similar to the systems and methods described herein, is employed with a surgical procedure for treatment of a spinal disorder, such as those described herein, affecting a section of a spine of a patient.", "Spinal implant system 10 may also be employed with other surgical procedures to treat the affected section of vertebrae V of a patient utilizing a surgical procedure, such as, for example, an OLIF and DLIF procedure.", "In some embodiments, spinal implant system 10 may include retractors constrained via frame or semi-constrained using elastic or partial frame.", "In some embodiments, a surgical instrument, such as, for example, a retractor T2 is disposed in communication with surgical pathway P, disposed relative to axis XL at an oblique angle α, as described herein, for spacing tissue, as shown in FIG.", "7.Retractor blades b1, b2 are inserted simultaneously as part of a unitary retractor instrument around one or more intervertebral spaces to protect vessels.", "In some embodiments, as shown in FIGS.", "5 and 6, an annulotomy and/or discectomy is performed with a surgical instrument (not shown) with x-ray confirmation of the starting point that is central on one or more intervertebral spaces.", "In some embodiments, spinal implant system 10 includes a semi-constrained retractor that facilitates minimal tissue pressures on surrounding abdominal structures and provides flexibility such that its blades rotate on a fixed pin allowing greater degrees of freedom of movement and working angles for a practitioner.", "In some embodiments, a probe is passed into a disc space to secure its location.", "In some embodiments, the oblique angle and lordotic angle of the probe as it enters the disc space is assessed preoperatively and measured intraoperative using image guidance or using a mechanical or digital protractor.", "Fluoroscopy, image guidance and/or surgical navigation, as described herein, are used to confirm proper probe alignment into the disc space.", "In some embodiments, a guide wire is placed through a cannula into the disc space and positioning is confirmed with fluoroscopy.", "Instruments, such as, for example, a Cobb, mallet, shaver, serrated curettes, rasp, a ring curette, a uterine curette and/or combo tools are utilized to perform a discectomy of a disc space.", "The instruments enter subject body B obliquely through retractor T2 and can be turned orthogonally to allow the surgeon to work orthogonally across the disc space.", "The disc space is distracted until adequate disc space height is obtained, as shown in FIG.", "6.In some embodiments, cage 12 is configured for insertion within an intervertebral space S. In some embodiments, trial implants are delivered along surgical pathway P and used to distract one or more intervertebral spaces and apply appropriate tension in the intervertebral space allowing for indirect decompression.", "In some embodiments, a direct decompression of the disc space is performed by removing a portion of a herniated disc.", "In some embodiments, the size of cage 12 is selected after trialing, cage 12 is visualized by fluoroscopy and oriented before malleting into space S. Trialing is utilized to establish a starting point for cage 12 insertion.", "In some embodiments, an anterior longitudinal ligament (ALL) release procedure can be performed using an OLIF or a DLIF approach post-discectomy.", "For example, loosening the ALL can be performed by placing holes or partial cuts in the ALL such that the OLIF surgical pathway is immediately closer to the ALL.", "A pilot hole or the like is made in vertebra V1 adjacent space S, via surgical pathway P, for receiving bone fastener 90.Cage 12 including member 54, as described herein, allows a surgeon to manipulate the cage 12 construct relative to retractor T2.For example, as shown in FIGS.", "7-9, inserter 70 is connected with member 54 such that portion 80 engages socket 78.Inserter 70 is translatable with member 54 between limits 58, 60, as described herein, to facilitate insertion of cage 12 along surgical pathway P into position between vertebra V1 and vertebra V2 relative to subject body B and/or cage 12 to provide selective positioning of cage 12 with respect to subject body B for adapting to the configuration of the tissue surfaces of vertebrae V. Inserter 70 and cage 12 are inserted along surgical pathway P substantially between blades b1, b2 of retractor T2, as shown in FIG.", "7.The surgeon may freely rotate inserter 70 and cage 12 into position relative to vertebrae V1, V2.After positioning cage 12, the surgeon may utilize inserter 70, connected with member 54, to rotate cage 12 into position within space S to obtain a selected position of cage 12 relative to vertebrae V1, V2.Inserter 70 orients cage 12 such that screw hole 42 is aligned oblique relative to axis XL.", "In some embodiments, cage 12 is selectively disposed with vertebrae V1, V2 such that screw hole 42 is substantially aligned with surgical pathway P relative to axis XL at angle α, which is equivalent to angle α1.Inserter 70 orients cage 12 such that surface 22 contacts and is disposed in flush engagement with an endplate E1 of vertebra V1, as shown in FIG.", "10.Surface 22 engages endplate E1 such that cage 12 defines a gap G between surface 24 and an endplate E2 of vertebra V2.Bone fastener 90 is disposed with screw hole 42 and engaged in fixation with vertebra V1 such that bone fastener 90 is oriented oblique relative to lateral axis XL, as shown in FIG.", "11.In some embodiments, cage 12 includes an alternately configured screw hole and/or is oriented with vertebrae V1, V2 such that bone fastener 90 is engaged in fixation with vertebra V2 such that bone fastener 90 is oriented oblique relative to lateral axis XL.", "In some embodiments, cage 12 includes a plurality of screw holes for disposal of bone fasteners 90 that are engaged in fixation with vertebra V1 and/or vertebra V2 in an oblique orientation relative to lateral axis XL.", "In some embodiments, after fixation of cage 12 with vertebra V1, portions of facet joints FJ, laminae L and/or spinous process SP are removed to facilitate selected angular correction of vertebrae V, as shown in FIGS, 12 and 13, with surgical instruments, external manipulation of subject body B and/or posterior fixation devices such as pedicle screws attached with vertebrae V1, V2.For example, implant supports, such as, for example, extenders can be attached to the pedicle screws attached with vertebrae V1, V2.The extenders/screws act as levers for reducing and/or rotating vertebrae V to reduce and/or eliminate gap G and/or until endplate E2 is disposed in flush engagement with surface 24 such that a selected angular correction of vertebrae V is achieved, as shown in FIG.", "14.In some embodiments, the components of spinal implant system 10 provide axial compression or distraction to restore vertebral body height, achieve lordosis and/or restore curvature of the spine.", "In some embodiments, a spinal construct including pedicle screws 100 and/or spinal rods 102, as shown in FIGS.", "15 and 16, are employed to provide posterior fixation of vertebrae V1, V2 in a selected orientation and/or angular correction.", "Upon completion of a procedure, as described herein, the surgical instruments, assemblies and non-implanted components of spinal implant system 10 are removed and the incision(s) are closed.", "One or more of the components of spinal implant system 10 can be made of radiolucent materials such as polymers.", "Radiopaque markers may be included for identification under x-ray, fluoroscopy, CT or other imaging techniques.", "In some embodiments, the use of surgical navigation, microsurgical and image guided technologies may be employed to access, view and repair spinal deterioration or damage, with the aid of spinal implant system 10.In some embodiments, spinal implant system 10 may include one or a plurality of plates, connectors and/or bone fasteners for use with a single vertebral level or a plurality of vertebral levels.", "In some embodiments, spinal implant system 10 includes an agent, which may be disposed, packed, coated or layered within, on or about the components and/or surfaces of spinal implant system 10.In some embodiments, the agent may include bone growth promoting material, such as, for example, bone graft to enhance fixation of the components and/or surfaces of spinal implant system 10 with vertebrae.", "In some embodiments, the agent may include one or a plurality of therapeutic agents and/or pharmacological agents for release, including sustained release, to treat, for example, pain, inflammation and degeneration.", "It will be understood that various modifications may be made to the embodiments disclosed herein.", "Therefore, the above description should not be construed as limiting, but merely as exemplification of the various embodiments.", "Those skilled in the art will envision other modifications within the scope and spirit of the claims appended hereto." ] ]
Patent_15872525
[ [ "SOURCE-AWARE TECHNIQUE FOR FACILITATING LISP HOST MOBILITY", "A method is provided in one example embodiment and includes detecting by a first network element at a first data center site a local connection of an endpoint identifier (“EID”), in which the EID was previously locally connected to a second network element at a second data center site and notifying a mapping server of the local connection of the EID to the first network element.", "The method further includes receiving from the mapping server identifying information for the second network element and communicating with the second network element using the identifying information to obtain service information for traffic associated with the EID.", "The method may also include applying a service identified by the service information to outgoing traffic from the EID as well as applying a service identified by the service information to incoming traffic for the EID." ], [ "1.A method comprising: detecting a local connection of a Location Identity Separation Protocol (“LISP”) endpoint identifier (“EID”) corresponding to a virtual machine (“VM”); receiving identifying information for a network element previously connected to the EID; and receiving service information for a service to be applied to traffic associated with the VM using the identification information.", "2.The method of claim 1, wherein, the local connection is detected by another network element at a first data center site, the EID was previously locally connected to the network element at a second data center site, and each of the first and second data center sites comprises a LISP-enabled site.", "3.The method of claim 1, wherein, the local connection is detected by another network element at a first data center site, the EID was previously locally connected to the network element at a second data center site, and each of the network elements comprises an ingress/egress tunnel router (“xTR”).", "4.The method of claim 1, wherein the service identified by the service information comprises a firewall, the method further comprising: establishing a communications channel between a firewall at a first data center site and a firewall at a second data center site; and initiating a state transfer from the firewall at the second data center site to the firewall at the first data center site.", "5.The method of claim 4, further comprising providing a filter to the firewall at the second data center site so that only states related to the EID are transferred to the firewall at the first data center site.", "6.The method of claim 4, wherein the state transfer is one of a signal-based event-driven bulk state transfer (“EDBST”) and a traffic-based event-driven state transfer (“EDST”).", "7.The method of claim 1, wherein the service identified by the service information comprises Network Based Application Recognition (“NBAR”), the method further comprising: subsequent to the detecting, sending a query to an NBAR controller to determine an action to be performed in connection with the traffic associated with the EID, wherein the query includes a tuple identifying the traffic associated with the EID, the tuple being used to index an entry of a flow table maintained by the NBAR controller, the indexed flow table entry indicating the action to be performed; receiving from the NBAR a query response comprising an indication of the action to be performed in connection with the traffic associated with the EID; and applying the indicated action.", "8.At least one non-transitory tangible media that includes code for execution and when executed by a processor is operable to perform operations comprising: detecting a local connection of a Location Identity Separation Protocol (“LISP”) endpoint identifier (“EID”) corresponding to a virtual machine (“VM”); receiving from identifying information for a network element previously connected to the LISP; and receiving service information for a service to be applied to traffic associated with the VM using the identification information.", "9.The at least one media of claim 8, wherein, the local connection is detected by another network element at a first data center site, the EID was previously locally connected to the network element at a second data center site, and each of the first and second data center sites comprises a LISP-enabled site.", "10.The at least one media of claim 8, wherein, the local connection is detected by another network element at a first data center site, the EID was previously locally connected to the network element at a second data center site, and each of the network elements comprises an ingress/egress tunnel router (“xTR”).", "11.The at least one media of claim 8, wherein a service identified by the service information comprises a firewall, the operations further comprising: establishing a communications channel between a first firewall at a first data center site and a second firewall at a second data center site; and initiating a state transfer from the second firewall to the first firewall.", "12.The at least one media of claim 11, further comprising: providing a filter to the second firewall so that only states related to the EID are transferred to the first firewall.", "13.The at least one media of claim 11, wherein the state transfer is one of a signal-based event-driven bulk state transfer (“EDBST”) and a traffic-based event-driven state transfer (“EDST”).", "14.The at least one media of claim 8, wherein a service identified by the service information comprises Network Based Application Recognition (“NBAR”), the operations further comprising: subsequent to the detecting, sending a query to an NBAR controller to determine an action to be performed in connection with the traffic associated with the EID, wherein the query includes a tuple identifying the traffic associated with the EID, the tuple being used to index an entry of a flow table maintained by the NBAR controller, the indexed flow table entry indicating the action to be performed; receiving from the NBAR a query response comprising an indication of the action to be performed in connection with the traffic associated with the EID; and applying the indicated action.", "15.An apparatus comprising: a memory element configured to store data; a processor operable to execute instructions associated with the data; and a first network element at a first data center configured to: detect a local connection of a Location Identity Separation Protocol (“LISP”) endpoint identifier (“EID”) corresponding to a virtual machine (“VM”); receive identifying information for a network element previously connected to the EID; and receiving service information for a service to be applied to traffic associated with the VM using the identification information.", "16.The apparatus of claim 15, wherein each of the network elements includes an ingress/egress tunnel router (“xTR”).", "17.The apparatus of claim 15, wherein a service identified by the service information comprises a firewall, and wherein a communications channel is established between a first firewall at a first data center site and a second firewall at the second data center site and a state transfer is initiated from the second firewall to the first firewall.", "18.The apparatus of claim 17, wherein a filter is provided to the second firewall so that only states related to the EID are transferred to the first firewall.", "19.The apparatus of claim 17, wherein the state transfer is one of a signal-based event-driven bulk state transfer (“EDBST”) and a traffic-based event-driven state transfer (“EDST”).", "20.The apparatus of claim 15, wherein a service identified by the service information comprises one of a firewall and Network Based Application Recognition (“NBAR”), the first network element further configured to: send a query to an NBAR controller to determine an action to be performed in connection with the traffic associated with the EID, wherein the query includes a tuple identifying the traffic associated with the EID, the tuple being used to index an entry of a flow table maintained by the NBAR controller, the indexed flow table entry indicating the action to be performed; receive from the NBAR a query response comprising an indication of the action to be performed in connection with the traffic associated with the EID; and apply the indicated action." ], [ "<SOH> BACKGROUND <EOH>The traditional IP addressing model associates both an identity and a location of a device to a single IP address space.", "This results in mobility being a very cumbersome process, as identity and location are so tightly bundled.", "LISP is a routing architecture in which an identifier of a device, referred to as its Endpoint Identifier (“EID”), and its location, identified by its Routing Locator (“RLOC”), are split into two different name spaces.", "LISP also provides a dynamic mapping mechanism between the two address families.", "RLOCs remain associated with the topology and are reachable via traditional routing; however EIDs can change location dynamically and are reachable via different RLOCs, depending on where an EID attaches to the network.", "In a virtualized data center deployment, EIDs can be directly assigned to virtual machines (“VMs”) that are free to migrate between data center sites while preserving their IP addressing information.", "LISP uses a dynamic tunneling encapsulation approach, rather than requiring the pre-configuration of tunnel endpoints.", "As previously noted, LISP name spaces include EID addresses, which include the IP address and previses identifying the endpoints, and RLOC addresses, which include the IP addresses and previses identifying the different routers in the network.", "EID reachability across LISP sites is achieved by resolving EID-to-RLOC mapping, while RLOC reachability is achieved by traditional routing methods.", "LISP sites may also include LISP site devices such as an Ingress Tunnel Router (“ITR”) and an Egress Tunnel Router (“ETR”).", "An ITR may comprise a LISP site edge device that receives packets from site-facing interfaces, or internal hosts, encapsulates the packets, and forwards them to remote LISP sites.", "The ITR may alternatively natively forward the packets to non-LISP sites.", "An ETR may comprise a LISP site edge device that receives packets from core-facing interfaces, or the transport infrastructure, decapsulates LISP packets, and delivers them to local EIDs at the site." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>To provide a more complete understanding of the present disclosure and features and advantages thereof, reference is made to the following description, taken in conjunction with the accompanying figures, wherein like reference numerals represent like parts, in which: FIG.", "1 is a simplified block diagram comprising features of one embodiment for providing host mobility in a LISP-enabled IP network; FIG.", "2 illustrates an example format of a LISP encapsulated packet in accordance with embodiments shown and described herein; FIG.", "3 is an annotated version of the simplified block diagram illustrated in FIG.", "1 ; FIG.", "4 is a flowchart illustrating an existing technique for implementing host mobility in a LISP-enabled IP network using the system depicted in FIG.", "3 ; FIG.", "5 is a simplified block diagram comprising features of one embodiment for providing source aware host mobility in a LISP-enabled IP network; FIG.", "6 is a flowchart illustrating a technique for implementing source aware host mobility in a LISP-enabled IP network using the system depicted in FIG.", "5 ; FIG.", "7 is a simplified block diagram comprising features of an embodiment for providing continuous Network Based Application Recognition (“NBAR”), service during LISP mobility in a LISP-enabled IP network; FIG.", "8 is a flowchart illustrating a technique for providing continuous NBAR service during LISP mobility in a LISP-enabled IP network using the system depicted in FIG.", "7 ; FIG.", "9 is a simplified block diagram comprising features of an embodiment for providing firewall mobility support in a LISP-enabled network; and FIG.", "10 is a flowchart illustrating a technique for implementing an event driven bulk state transfer for providing firewall mobility support in the system illustrated in FIG.", "9 .", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "TECHNICAL FIELD This disclosure relates in general to data communications networks and, more particularly, to a source-aware technique for facilitating Location Identity Separation Protocol (“LISP”) host mobility in such networks.", "BACKGROUND The traditional IP addressing model associates both an identity and a location of a device to a single IP address space.", "This results in mobility being a very cumbersome process, as identity and location are so tightly bundled.", "LISP is a routing architecture in which an identifier of a device, referred to as its Endpoint Identifier (“EID”), and its location, identified by its Routing Locator (“RLOC”), are split into two different name spaces.", "LISP also provides a dynamic mapping mechanism between the two address families.", "RLOCs remain associated with the topology and are reachable via traditional routing; however EIDs can change location dynamically and are reachable via different RLOCs, depending on where an EID attaches to the network.", "In a virtualized data center deployment, EIDs can be directly assigned to virtual machines (“VMs”) that are free to migrate between data center sites while preserving their IP addressing information.", "LISP uses a dynamic tunneling encapsulation approach, rather than requiring the pre-configuration of tunnel endpoints.", "As previously noted, LISP name spaces include EID addresses, which include the IP address and previses identifying the endpoints, and RLOC addresses, which include the IP addresses and previses identifying the different routers in the network.", "EID reachability across LISP sites is achieved by resolving EID-to-RLOC mapping, while RLOC reachability is achieved by traditional routing methods.", "LISP sites may also include LISP site devices such as an Ingress Tunnel Router (“ITR”) and an Egress Tunnel Router (“ETR”).", "An ITR may comprise a LISP site edge device that receives packets from site-facing interfaces, or internal hosts, encapsulates the packets, and forwards them to remote LISP sites.", "The ITR may alternatively natively forward the packets to non-LISP sites.", "An ETR may comprise a LISP site edge device that receives packets from core-facing interfaces, or the transport infrastructure, decapsulates LISP packets, and delivers them to local EIDs at the site.", "BRIEF DESCRIPTION OF THE DRAWINGS To provide a more complete understanding of the present disclosure and features and advantages thereof, reference is made to the following description, taken in conjunction with the accompanying figures, wherein like reference numerals represent like parts, in which: FIG.", "1 is a simplified block diagram comprising features of one embodiment for providing host mobility in a LISP-enabled IP network; FIG.", "2 illustrates an example format of a LISP encapsulated packet in accordance with embodiments shown and described herein; FIG.", "3 is an annotated version of the simplified block diagram illustrated in FIG.", "1; FIG.", "4 is a flowchart illustrating an existing technique for implementing host mobility in a LISP-enabled IP network using the system depicted in FIG.", "3; FIG.", "5 is a simplified block diagram comprising features of one embodiment for providing source aware host mobility in a LISP-enabled IP network; FIG.", "6 is a flowchart illustrating a technique for implementing source aware host mobility in a LISP-enabled IP network using the system depicted in FIG.", "5; FIG.", "7 is a simplified block diagram comprising features of an embodiment for providing continuous Network Based Application Recognition (“NBAR”), service during LISP mobility in a LISP-enabled IP network; FIG.", "8 is a flowchart illustrating a technique for providing continuous NBAR service during LISP mobility in a LISP-enabled IP network using the system depicted in FIG.", "7; FIG.", "9 is a simplified block diagram comprising features of an embodiment for providing firewall mobility support in a LISP-enabled network; and FIG.", "10 is a flowchart illustrating a technique for implementing an event driven bulk state transfer for providing firewall mobility support in the system illustrated in FIG.", "9.DETAILED DESCRIPTION OF EXAMPLE EMBODIMENTS Overview A method is provided in one example embodiment and includes detecting by a first network element at a first data center site a local connection of an endpoint identifier (“EID”), in which the EID was previously locally connected to a second network element at a second data center site and notifying a mapping server of the local connection of the EID to the first network element.", "The method further includes receiving from the mapping server identifying information for the second network element and communicating with the second network element using the identifying information to obtain service information for traffic associated with the EID.", "The method may also include applying a service identified by the service information to outgoing traffic from the EID as well as applying a service identified by the service information to incoming traffic for the EID.", "In certain embodiments, each of the first and second data center sites may be a Location Identity Separation Protocol (“LISP”)-enabled site.", "In some embodiments, each of the first and second network elements may include an ingress/egress tunnel router (“xTR”).", "A service identified by the service information may include a firewall, in which case the method may further include establishing a communications channel between a firewall at the first data center site and a firewall at the second data center site; and initiating a state transfer from the firewall at the second data center site to the firewall at the first data center site.", "In some instances, the method may also include providing a filter to the firewall at the second data center site so that only states related to the EID are transferred to the firewall at the first data center site.", "The state transfer may be one of a signal-based event-driven bulk state transfer (“EDBST”) and a traffic-based event-driven state transfer (“EDST”).", "A service identified by the service information may also include Network Based Application Recognition (“NBAR”), in which case the method may further include, subsequent to the detecting, sending a query to an NBAR controller to determine an action to be performed in connection with the traffic associated with the EID, in which the query includes a tuple identifying with the traffic associated with the EID, the tuple being used to index an entry of a flow table maintained by the NBAR controller, the indexed flow table entry indicating the action to be performed; receiving from the NBAR a query response comprising an indication of the action to be performed in connection with the traffic associated with the EID; and applying the indicated action.", "EXAMPLE EMBODIMENTS The increasing use of virtualization in the data center has enabled an unprecedented degree of flexibility in managing servers and workloads.", "A key to leveraging this flexibility is mobility; workloads hosted on virtual servers are decoupled from the physical infrastructure and become mobile by definition.", "As a result, the routing infrastructure is challenged to evolve from a topology-centric addressing model to a more flexible architecture that permits IP addresses to freely and efficiently move across the infrastructure.", "There are several ways of adding mobility to an IP infrastructure, each of which addresses the problem with different degrees of effectiveness.", "LISP host mobility is one such solution.", "Various details regarding LISP implementation can be found in Internet Engineering Task Force Request for Comments 6830 entitled “Locator/ID Separation Protocol (LISP)” (“IETF RFC 6830”), which is hereby incorporated by reference in its entirety.", "It will be recognized that there are certain fundamental aspects that must be addressed in an IP mobility solution, such as LISP host mobility.", "These include redirection, scalability, routing optimization, client independence, and address family agnosticism.", "With regard to redirection, a primary goal of IP mobility is to direct traffic to the actual location of the specified end point.", "This goal is typically addressed by providing a redirection mechanism to enhance traffic steering already provided by the basic routing mechanism.", "This may be accomplished through replacing the destination's address or by leveraging a level of indirection in addressing such as may be achieved with tunnels and encapsulation.", "Ultimately, IP mobility should provide a solution that is totally transparent to the applications and allows for the preservation of established sessions, as end-points move around the IP infrastructure.", "As for scalability, most IP mobility techniques create a significant amount of granular state to effectively redirect traffic, which granular state is necessary to correlate destination IP addresses to specific locations, either through mapping or translation.", "This increase in state must be handled efficiently to attain a solution that can support a deployable scale at a cost, in terms of memory and processing, that is not unreasonable.", "With regard to routing optimization, as endpoints roam, traffic must still be routed to the endpoints via the best possible path.", "The ability to optimize the path is largely a function of the location of the redirecting element.", "A mobility solution must provide optimized paths regardless of the location of the endpoint.", "It is also important that the mobility solution not depend on agents installed on the endpoints or the clients communicating with the endpoints.", "The solution should therefore be network-based, given the large installed base of endpoints that presumably cannot be changed or managed at will to install client software.", "In the context of address family agnosticism, the IP mobility solution should work independently of IPv4 or IPv6 endpoints and network.", "Since mobility relies on manipulating the mapping of identity to location, address families with longer addresses tend to offer alternatives not available with shorter addresses.", "Address-dependent solutions have limited application because they generally require an end-to-end deployment of IPv6; the ideal solution should work for either IPv4 or IPv6.As previously noted, the traditional IP addressing model associates both location and identity to a single IP address space, which makes mobility cumbersome.", "By providing two separate address spaces for location and identity, LISP provides a dynamic mapping mechanism.", "RLOCs remain associated with the topology and are reachable by traditional routing; however, EIDs can change location dynamically and are reachable via different RLOCs depending on where the EID attaches to the network.", "In a virtualized data center deployment, for example, EIDs can be assigned to virtual machines (“VMs”) that are free to migrate between sites while preserving their IP addressing information.", "In this manner, LISP host mobility allows the EID space to be mobile without affecting the routing that interconnects the RLOC space.", "When a move from one LISP-enabled site to another is detected, as described below, EID-to-RLOC mappings are updated by the Ingress/Egress Tunnel Router (“xTR”) of the new site.", "Moves are detected by configuring xTRs to compare the source in the IP header of traffic received from a host against a range of previses that are allowed to roam.", "These prefixes are defined as dynamic EIDs.", "When deployed at the first hop router (xTR), LISP devices also provide adaptable and comprehensive first hop router functionality to service the IP gateway needs of roaming devices that relocate.", "In general, LISP host mobility functionality allows any IP-addressable device, or “host,” to move, or “roam,” from its subnet to another subnet or to a different location, such as a remote data center, while maintaining its original IP address.", "In the context of LISP, a device that moves may be referred to as a “roaming device,” and its IP address is its EID.", "An xTR configured for LISP host mobility is typically positioned at the aggregation layer of a data center to enable the xTR function to be collocated on the device that functions as the default gateway.", "As will be described in detail below, LISP xTR devices dynamically determine when a workload moves into or away from one of its directly connected subnets.", "Referring first to FIG.", "1, illustrated therein is a system 10 comprising features of one embodiment for providing host mobility in a LISP-enabled IP network 11.As shown in FIG.", "1, the network 10 includes multiple LISP-enabled sites, represented in FIG.", "1 by sites 12A, 12B, and 12C.", "In the illustrated embodiment, the site 12A is a remote LISP-enabled site and the sites 12B and 12C comprise data center sites.", "Each of the sites 12A-12C includes an xTR device, represented in FIG.", "1 by xTRs 14A, 14B, and 14C, respectively.", "It will be noted that an xTR is a LISP site edge device that implements the functions of both an ITR and an ETR, thereby to enable establishment of bidirectional flows via the device.", "Each of the sites 12A-12C is connected to a server 16 via its respective xTR 14A-14C.", "The server 16 may comprise functionality for implementing both a Map-Server (“MS”) 18 and a Map-Resolver (“MR”) 20.The MS and MR (collectively MS/MR) are key components in a LISP deployment.", "They provide the ability to store and restore EID-to-RLOC mapping information for the LISP routers (xTRs) to route between LISP-enabled sites.", "The MS is a LISP infrastructure device with which the ETR functionality of each LISP-enabled site (implemented in the xTR of the site in the embodiment shown in FIG.", "1) registers its EID prefix(s).", "The MS stores the registered EID prefixes in a mapping database with each EID prefix mapped to an associated RLOC.", "All LISP-enabled sites of the network 10 use the MS 18 to resolve EID-to-RLOC mappings.", "The MR is a LISP infrastructure device to which ITR functionality of each LISP-enabled site (implemented in the xTR of the site in the embodiment shown in FIG.", "1) sends LISP map-request queries when resolving EID-to-RLOC mappings.", "Upon receipt of a map request query, the MR finds the appropriate EID-to-RLOC mapping by checking with the MS, which may be co-located or distributed.", "For purposes of illustration and example herein, it will be assumed that the MS and MR are collocated.", "LISP functionality may consist of data plane and control plane functions.", "The steps required to establish communication between devices in LISP-enabled sites in accordance with embodiments described herein may include the following.", "First, a client, such as a client 24, in a remote LISP-enabled site, such as site 12A, queries through DNS the IP address of a destination server deployed at one of the LISP-enabled data center sites (sites 12B and 12C in FIG.", "1).", "Next, traffic originating from the client is steered toward the local LISP-enabled device, which is usually the client's default gateway.", "The LISP-enabled device performs a lookup for the destination server in its routing table.", "Since the destination is an EID subnet, it is not present in the RLOC space, so the lookup fails, triggering the LISP control plane.", "The ITR functionality of the remote xTR (e.g., xTR 14A), receives valid mapping information from the mapping database and populates its local map cache.", "It should be noted that the destination EID subnet may be associated with RLOCs identifying the ETR functionality of multiple xTR devices at the data center LISP-enabled site.", "Also, each map cache entry may have associated therewith priority and weight values that are controlled by the destination site used to receive LISP encapsulated traffic designated to a local EID subnet.", "The weight allows tuning the amount of traffic received by the ETR functionality of each xTR in a load-balancing scenario.", "On the data plane, the ITR functionality of the xTR of the remote site performs LISP encapsulation of the IP traffic originated by the device and sends it to the transport infrastructure designed for one of the RLOCs of the ETR functionality of the data center xTRs.", "Assuming the priority and weight values are configured equally for the ETR functionality of each xTR device, the selection of the specific xTR RLOC may be performed on a per-flow basis based on hashing, for example.", "FIG.", "2 illustrates the format of a LISP encapsulated packet in accordance with one embodiment.", "As shown in FIG.", "2, LISP leverages a User Datagram Protocol (“UDP”) encapsulation where the source port value is dynamically created and associated with each original flow to ensure better load balancing of traffic across the transport infrastructure.", "Finally, the ETR functionality at the data center xTR receives the packet, decapsulates it, and forwards it into the site toward the destination EID.", "It should be noted that a similar mechanism would be used for return traffic originated by the data center EID and destined for the client.", "The LISP control plane may operate as follows.", "First, the ETR functionality of each xTR registers with the MS the one or more EID subnets that are locally defined and over which it has authority.", "Map-registration messages are sent periodically every 60 seconds by each xTR via its ETR functionality.", "Assuming that a local map cache entry is not available, when a client at a remote site wants to establish communication with a DC EID, a map-request is sent by the ITR functionality of the remote site xTR to the MR, which then forwards the message to the MS.", "The MS forwards the original map-request to the ETR functionality of the xTR that last registered the EID subnet.", "The ETR functionality of the xTR then sends a map-reply containing the requested mapping information to the ITR functionality of the remote xTR.", "The ITR functionality then installs the mapping information in a local map cache maintained by the remote xTR and starts encapsulating traffic toward the data center EID destination.", "FIG.", "3 illustrates an annotated version of the system 10 of FIG.", "1, which will be referenced in connection with a flowchart shown in FIG.", "4 to describe an example LISP host mobility solution in accordance with previous embodiments.", "It will be assumed for the sake of illustration that a client 24 at remote site 12A has been communicating with a particular EID, at data center site 14B.", "In step 50 (represented by a line 1 in FIG.", "3), when the EID moves from data center site 12B to data center site 12C, the xTR of site 12C (i.e., xTR 14C) will detect the presence of the new EID on its subnet.", "In step 52 (represented in FIG.", "3 by a line 2), the new xTR (xTR 14C) notifies the MS 18 of the new location of the EID and updates the location of the new EID, indicating that the EID now belongs to a subnet of site 12C.", "In step 54 (represented in FIG.", "3 by a line 3), the MS 18 communicates back to the xTR of the site from which the EID moved (i.e., xTR 14B) that the EID has moved and instructs the xTR to update its routing tables accordingly to reflect the move.", "It will be noted that at this point, the xTR of the remote site (xTR 14A) will continue to send LISP packets for the EID to the xTR serving the data center site that was the previous location of the EID, having not yet been advised of the EID move.", "In step 56 (represented in FIG.", "3 by a line 4), upon receipt at the xTR of the first data center site (xTR 14B) of packets from the xTR of the remote site (xTR 14A) of packets destined for the EID, the xTR 14B sends an Solicit-Map-Request (“SMR”) message to xTR 14A.", "In step 58, decapsulates the received packets, encapsulates them with a LISP UDP tunnel, and forwards them to xTR 14C, which will ultimately route them to the EID at its new location.", "In step 60 (represented in FIG.", "3 by a line 5), in response to the SMR message, xTR 14A initiates a map request process for the new RLOC for host EID.", "In step 62 (represented in FIG.", "3 by a line 6), MR/MS checks the LISP database and obtains the new RLOC xTR 14C and then informs xTR 14C that there is a request from xTR 14A for the EID.", "In step 64 (represented in FIG.", "3 by a line 7), an updated map-reply is issued from the new location (xTR 14C) to xTR 14A and the traffic between the host and EID is adjusted to new RLOC xTR 14A and xTR 14C, respectively.", "As described above, if xTRs 14B and 14C never communicated with one another, xTR 14C would have no way of knowing the original xTR of the moved host (xTR 14B, in the illustrated example).", "This could cause trouble for those services, including Layer 3 (“L3”) and Layer 4 (“L4”) firewalls and a variety of Layer 7 (“L7”) services, that can work on the original xTR but cannot work on the new xTR.", "For example, in the case of a firewall, the traffic session is recorded on the original xTR but the session information just gets lost on the new xTR.", "Additionally, in the case of Network Based Application Recognition (“NBAR”), NBAR can detect traffic type and apply NBAR action to traffic flow on the original xTR, but on the new xTR, the traffic characteristic has already been lost, such that NBAR cannot work on the new xTR.", "In accordance with features of embodiments described herein, a technique is provided for a simple and stable mechanism to provide a source aware process for LISP host mobility in which the MS/MR notifies an xTR to which an EID has moved (the “destination xTR”) of the identity of the xTR from which the EID has moved (the “source xTR”).", "As will be described in greater detail below with reference to FIGS.", "9 and 10, in certain embodiments, a LISP control plane may establish a communication channel between the destination xTR and the source xTR in order to sync firewall sessions from the source to the destination.", "FIG.", "5 illustrates a system 70 comprising features of one embodiment for providing source-aware host mobility in a LISP-enabled IP network 71.Similar to FIG.", "1, the network 70 includes multiple LISP-enabled sites, represented in FIG.", "5 by sites 72A, 72B, and 72C.", "In the illustrated embodiment, the site 72A is a remote LISP-enabled site and the sites 72B and 72C comprise data center sites.", "Each of the sites 72A-72C includes an xTR device, represented in FIG.", "5 by xTRs 74A, 74B, and 74C, respectively.", "It will be noted that an xTR is a LISP site edge device that implements the functions of both an ITR and an ETR, thereby to enable establishment of bidirectional flows via the device.", "Each of the sites 72A-72C is connected to a server 76 via its respective xTR 74A-74C.", "The server 76 may comprise functionality for implementing both a Map-Server (“MS”) 78 and a Map-Resolver (“MR”) 80.As with FIGS.", "1 and 3, for purposes of illustration and example herein, it will be assumed that the MS 78 and MR 80 are collocated.", "FIG.", "6 is a flowchart illustrating operation of FIG.", "5 in connection with embodiments described herein for implementing a source aware LISP mobility solution.", "It will be assumed for the sake of illustration that a client 88 at remote site 72A has been communicating with a particular EID, at data center site 74B.", "In step 90 (represented by a line 1 in FIG.", "5), when the EID moves from data center site 72B to data center site 72C, the xTR of site 72C (i.e., xTR 74C) will detect the presence of the new EID on its subnet.", "In step 92 (represented in FIG.", "5 by a line 2), the new xTR (xTR 74C) notifies the MS 78 of the new location of the EID and updates the location of the new EID, indicating that the EID now belongs to a subnet of site 72C.", "In step 93 (represented in FIG.", "5 by a line 3), the mapping server notifies the xTR of the data center site to which the EID has moved (xTR 74C) of information identifying the xTR of the data center site at which the EID was previously located (xTR 74B).", "The destination xTR (XTR 74C) saves this information to be used in communicating with the source xTR (xTR 74B) to retrieve service information to be applied to outgoing traffic.", "This information has been heretofore not consistently available to the destination xTR.", "In step 94 (represented in FIG.", "5 by a line 4), the MS 78 communicates back to the xTR of the site from which the EID moved (i.e., xTR 74B) that the EID has moved and instructs the xTR to update its routing tables accordingly to reflect the move.", "It will be noted that at this point, the xTR of the remote site (xTR 74A) will continue to send LISP packets for the EID to the xTR serving the data center site that was the previous location of the EID, having not yet been advised of the EID move.", "In step 96 (represented in FIG.", "5 by a line 5), upon receipt at the xTR of the first data center site (xTR 74B) of packets from the xTR of the remote site (xTR 74A) of packets destined for the EID, the xTR 74B sends an Solicit-Map-Request (“SMR”) message to xTR 74A.", "Additionally, the destination xTR (xTR 74C) communicates with the source xTR (xTR 74B) to obtain service information to be applied to the incoming traffic.", "In certain embodiments, as described in greater detail below with reference to FIGS.", "9 and 10, a firewall can perform either an event-driven sync, which involves syncing of one firewall state at a time, or a bulk sync.", "In step 98, the source xTR decapsulates the received packets, encapsulates them with a LISP UDP tunnel, and forwards them to the destination xTR (xTR 74C), which will ultimately route them to the EID at its new location.", "At this point, however, for traffic going into the destination xTR, services can communicate with the source xTR to immediately obtain service info and apply the service action to the incoming traffic.", "In step 100 (represented in FIG.", "5 by a line 6), in response to the SMR message, xTR 74A initiates a map request process for the new RLOC for host EID.", "In step 102 (represented in FIG.", "5 by a line 7), MR/MS checks the LISP database and obtains the new RLOC xTR 74C and then informs xTR 74C that there is a request from xTR 74A for the EID.", "In step 104 (represented in FIG.", "5 by a line 9), an updated map-reply is issued from the new location (xTR 74C) to xTR 74A and the traffic between the host and EID is adjusted to new RLOC xTR 74A and xTR 74C, respectively.", "The embodiments described herein comprise mechanisms for implementing a source aware technique for LISP mobility.", "It should be noted that, although FIG.", "6 illustrates a process in which the MS/MR operates as a proxy for the new xTR, it would be possible to revise steps 102 and 104 such that the MS/MR would provide the EID directly to the requesting xTR (in this case, the remote xTR) on request without forwarding the request to the new xTR.", "As previously noted, prior to embodiments described herein, when LISP was interworking with a service such as NBAR, the NBAR service would likely have been lost upon movement of an EID from one xTR/LISP-enabled site to another.", "This is at least partly due to the fact that the previous and current xTRs are typically not High Availability (“HA”) peers, so NBAR flow information was not previously synced between the xTRs.", "Additionally, in a LISP solution, there are likely numerous xTRs to which the host may be moved and it is not workable to put all of the xTR boxes into a single HA group.", "Therefore, in accordance with features of another embodiment, which may be implemented in concert with or as an alternative to the embodiments shown and described with reference to FIGS.", "5 and 6, order to provide continuous NBAR service when LISP mobility occurs, an NBAR controller may be introduced into the LISP deployment.", "In accordance with features of another embodiment described herein, a technique is provided for providing continuous NBAR service during LISP mobility.", "FIG.", "7 illustrates a system 110 comprising features of one embodiment for providing continuous NBAR service during LISP mobility in a LISP-enabled IP network 111.The network 110 includes multiple LISP-enabled sites, represented in FIG.", "7 by sites 112A, 112B, and 112C, as well as a non-LISP site 113.Each of the sites 112A-112C includes an xTR device, represented in FIG.", "7 by xTRs 114A, 114B, and 114C, respectively.", "As previously noted, an xTR is a LISP site edge device that implements the functions of both an ITR and an ETR, thereby to enable establishment of bidirectional flows via the device.", "The non-LISP site 113 is connected via a router 116 to a proxy xTR 118, which functions to connect LISP sites, such as sites 112A-112C, to non-LISP sites, such as site 113.In accordance with features of embodiments described herein, an NBAR controller 120 is provided and maintains an NBAR flow table 122 for purposes that will be described hereinbelow.", "In general, NBAR controller is a central place (logical or physical) that maintains NBAR traffic flow information in the NBAR flow table 122 and tuple (e.g., five-tuple or seven-tuple) indexes the traffic flow information.", "The traffic flow information is used to save the NBAR service, or action, to be applied to the traffic flow.", "FIG.", "8 is a flowchart illustrating operation of the embodiment shown in FIG.", "7 for providing continuous NBAR service during LISP mobility.", "It will be assumed for the sake of illustration that a client 124 at non-LISP site 113 and a client 126 at LISP-enabled site 112C have each been communicating with a particular EID originally located at site 112A.", "In step 130, (represented by a line 1 in FIG.", "7), an NBAR service on the xTR at site 112A (i.e., xTR 114A) detects the traffic flow for each device, applies the NBAR action to each flow, and saves the flows to the NBAR controller 120, which tuple indexes the flows in the flow table 122.In step 132 (represented in FIG.", "7 by a line 2), upon detection of movement of the EID from the source xTR (e.g., xTR 112A) to a destination xTR (e.g., xTR 112B), the NBAR service will first query the NBAR controller to determine whether the traffic has already been detected by another xTR.", "The tuple is carried in the query message.", "In step 134 (represented in FIG.", "7 by a line 3), upon receiving the query message, the NBAR controller 120 searches the NBAR flow table 122 using the tuple index and constructs a query response.", "In step 136 (represented in FIG.", "7 by a line 4), the NBAR controller 120 sends the query response to xTR 114B.", "In step 138 (represented in FIG.", "7 by a line 5), upon receipt of the query response from the NBAR controller 120, xTR 114B checks the query result and takes the appropriate action.", "For example, if the traffic flow has already been detected (i.e., there is a record in the NBAR flow table 122), the NBAR service just applies the indicated NBAR action to the traffic flow.", "If the traffic flow has not been detected, NBAR just continues with the current behavior.", "In this manner, NBAR can still apply quality of service (“QoS”) on the traffic flow after an EID moves from one xTR/LISP-enabled site to another.", "Additionally, traffic detection efforts can be saved, since the traffic flow has already been detected.", "Finally, existing NBAR QoS policy is provisioned on each xTR separately.", "Sometimes, the configuration may be wrong on a certain xTR and then the xTR will take the wrong QoS action.", "The presence of an NBAR controller enables QoS policy to be distributed to all xTRs to make sure that all xTRs have the same NBAR QoS policy.", "As previously noted, in certain embodiments, to ensure that firewall services are continued after movement of an EID from a source site to a destination site, firewall state information must be moved with the EID.", "FIG.", "9 illustrates a system 150 comprising features of one embodiment for providing firewall mobility support in a LISP-enabled network.", "The system 150 includes multiple LISP-enabled data center sites, represented in FIG.", "9 by sites 152A and 152B, as well as a client site 153.Each of the sites 152A, 152B, includes a pair of xTR devices 154A-154D.", "Each of the sites 152A, 152B, also includes a pair of firewalls 156A-156D, each of which is connected to a corresponding one of the xTRS 152A-152D.", "The pair of firewalls 156A-156B is connected to a first hop router (“FHR”) 158A.", "Similarly, the pair of firewalls 156C-156D is connected to a FHR 158B.", "An MS/MR 160, the functionality of which has been described in detail above, is also provided.", "It will be assumed for the sake of example that an EID 162 is moved from site 152A to site 152B (as represented by a dotted line 163) in the middle of a stateful conversation with a device at client site 153.It will be further assumed that at that point, state 164 is maintained by firewall 156A.", "After the move, FHR 158B discovers the presence of the EID on its subnet and signals local xTRs 152C-152D, which register EID presence with MS/MR 160.XTRs 152A, 152B, and FHR 158A are notified of the EID move by FHR 158B and MS/MR 160, as described above.", "XTRs 152A, 152B, send an SMR to the device at the client site 152, which updates its cache, and traffic to EID 162 is now routed to xTRs 152C and 152D.", "At this point, however, state still remains at firewall 156A; if left unattended, when incoming EID traffic reaches firewall 156D destined for FHR 158B, as there is no state associated with the conversation at firewall 156D, traffic would be dropped and a new session would need to be established.", "In accordance with features of one embodiment, the firewall state is moved from the source firewall (e.g., firewall 156A) to the destination firewall (e.g., firewall 156D) to prevent traffic from being dropped upon arrival at the destination firewall.", "In one embodiment, a state sync is triggered by the MS/MR 160 or LISP control plane, which notifies the firewall 156D where the state for the traffic is located (in this case, firewall 156A).", "Firewall 156D then obtains the state 164 from firewall 156A (as represented by a dotted line 170) (in a manner such as described in greater detail below) via a communication channel established by MS/MR 160 or the LISP control plane to pass state sync messages between the firewall pairs.", "State may be obtained from the source firewall by the destination firewall using one of several approaches.", "One such approach is referred to herein as a signal-based event-driven bulk state transfer (“EDBST”) approach.", "In the signal-based EDBST, firewalls are auto-provisioned with a dynamic server subnet.", "Firewalls with state information are notified that an EID has moved to a specific firewall group; consequently, the source and destination firewalls initiate a bulk state transfer.", "This method is granular and scalable and provides state duplication before the server traffic is steered.", "Another approach is referred to herein as a traffic-based EDST approach.", "In the traffic-based EDST approach, firewall peering pairs in the source and destination sites are notified by the MS/MR when an EID move is detected.", "Each time traffic to the dynamic server subnet hits a firewall and there is no associated state, a state-sync request is sent to the peering pairs, which send their state information.", "In this approach, a dynamic server subnet may not be required due to the fact that a filter is not required, since state is synced per request.", "Both the signal-based EDBST approach and the traffic-based EDST approach rely on notification from the MS/MR or LISP control plane to link the source firewall with the destination firewall, as described above.", "FIG.", "10 is a flowchart illustrating an EDBST approach to moving firewall state.", "In step 180, the MS/MR or LISP control plane establishes a communication channel between the source firewall and the destination firewall(s) to pass state sync messages after the MS/MR or LISP control plane detects the move.", "In step 182, the MS/MR provides a filter to the source firewall so that only states that are related to the relocated EID will be transferred.", "In step 184, the LISP control plane signals the source firewall to begin a bulk firewall state sync to the destination firewall(s) by sending a state-sync request to the source firewall.", "In one example implementation, various devices involved in implementing the embodiments described herein can include software for achieving the described functions.", "For example, each of the xTRs, MS/MR server, and NBAR controller illustrated in the FIGURES may be implemented using one or more computer devices comprising software embodied in one or more tangible media for facilitating the activities described herein.", "The computer device for implementing each of the xTRs, MS/MR server, and NBAR controller may also include a memory device (or memory element) for storing information to be used in achieving the functions as outlined herein.", "Additionally, the computer device for implementing the each of the xTRs, MS/MR server, and NBAR controller may include a processor that is capable of executing software or an algorithm to perform the functions as discussed in this Specification, including but not limited to the functions illustrated in and described with reference to the FIGURES.", "These devices may further keep information in any suitable memory element (random access memory (“RAM”), ROM, EPROM, EEPROM, ASIC, etc.", "), software, hardware, or in any other suitable component, device, element, or object where appropriate and based on particular needs.", "Any of the memory items discussed herein should be construed as being encompassed within the broad term “memory element.” Similarly, any of the potential processing elements, modules, and machines described in this Specification should be construed as being encompassed within the broad term “processor.” Each of the network elements can also include suitable interfaces for receiving, transmitting, and/or otherwise communicating data or information in a network environment.", "Note that in certain example implementations, the functions outlined herein and shown in the FIGURES may be implemented by logic encoded in one or more tangible media (e.g., embedded logic provided in an application specific integrated circuit (“ASIC”), digital signal processor (“DSP”) instructions, software (potentially inclusive of object code and source code) to be executed by a processor, or other similar machine, etc.).", "In some of these instances, a memory element can store data used for the operations described herein.", "This includes the memory element being able to store software, logic, code, or processor instructions that are executed to carry out the activities described in this Specification, including but not limited to the functions illustrated in and described with reference to the FIGUREs.", "A processor can execute any type of instructions associated with the data to achieve the operations detailed herein in this Specification.", "In one example, the processor could transform an element or an article (e.g., data) from one state or thing to another state or thing.", "In another example, the activities outlined herein may be implemented with fixed logic or programmable logic (e.g., software/computer instructions executed by a processor) and the elements identified herein could be some type of a programmable processor, programmable digital logic (e.g., a field programmable gate array (“FPGA”), an erasable programmable read only memory (“EPROM”), an electrically erasable programmable ROM (“EEPROM”)) or an ASIC that includes digital logic, software, code, electronic instructions, or any suitable combination thereof.", "It should be noted that much of the infrastructure discussed herein can be provisioned as part of any type of network element.", "As used herein, the term “network element” or “network device” can encompass computers, servers, network appliances, hosts, routers, switches, gateways, bridges, virtual equipment, load-balancers, firewalls, processors, modules, or any other suitable device, component, element, or object operable to exchange information in a network environment.", "Moreover, the network elements may include any suitable hardware, software, components, modules, interfaces, or objects that facilitate the operations thereof.", "This may be inclusive of appropriate algorithms and communication protocols that allow for the effective exchange of data or information.", "In one implementation, network elements/devices can include software to achieve (or to foster) the activities discussed herein.", "This could include the implementation of instances of any of the components, engines, logic, etc.", "shown in the FIGURES.", "Additionally, each of these devices can have an internal structure (e.g., a processor, a memory element, etc.)", "to facilitate some of the operations described herein.", "In other embodiments, these activities may be executed externally to these devices, or included in some other network element to achieve the intended functionality.", "Alternatively, these network devices may include software (or reciprocating software) that can coordinate with other network elements in order to achieve the management activities described herein.", "In still other embodiments, one or several devices may include any suitable algorithms, hardware, software, components, modules, interfaces, or objects that facilitate the operations thereof.", "Note that with the example provided above, as well as numerous other examples provided herein, interaction may be described in terms of two, three, or four network elements.", "However, this has been done for purposes of clarity and example only.", "In certain cases, it may be easier to describe one or more of the functionalities of a given set of flows by only referencing a limited number of network elements.", "It should be appreciated that topologies illustrated in and described with reference to the accompanying FIGURES (and their teachings) are readily scalable and can accommodate a large number of components, as well as more complicated/sophisticated arrangements and configurations.", "Accordingly, the examples provided should not limit the scope or inhibit the broad teachings of the illustrated topologies as potentially applied to a myriad of other architectures.", "It is also important to note that the steps in the preceding flow diagrams illustrate only some of the possible signaling scenarios and patterns that may be executed by, or within, communication systems shown in the FIGURES.", "Some of these steps may be deleted or removed where appropriate, or these steps may be modified or changed considerably without departing from the scope of the present disclosure.", "In addition, a number of these operations have been described as being executed concurrently with, or in parallel to, one or more additional operations.", "However, the timing of these operations may be altered considerably.", "The preceding operational flows have been offered for purposes of example and discussion.", "Substantial flexibility is provided by communication systems shown in the FIGURES in that any suitable arrangements, chronologies, configurations, and timing mechanisms may be provided without departing from the teachings of the present disclosure.", "Although the present disclosure has been described in detail with reference to particular arrangements and configurations, these example configurations and arrangements may be changed significantly without departing from the scope of the present disclosure.", "For example, although the present disclosure has been described with reference to particular communication exchanges, embodiments described herein may be applicable to other architectures.", "Numerous other changes, substitutions, variations, alterations, and modifications may be ascertained to one skilled in the art and it is intended that the present disclosure encompass all such changes, substitutions, variations, alterations, and modifications as falling within the scope of the appended claims.", "In order to assist the United States Patent and Trademark Office (USPTO) and, additionally, any readers of any patent issued on this application in interpreting the claims appended hereto, Applicant wishes to note that the Applicant: (a) does not intend any of the appended claims to invoke paragraph six (6) of 35 U.S.C.", "section 112 as it exists on the date of the filing hereof unless the words “means for” or “step for” are specifically used in the particular claims; and (b) does not intend, by any statement in the specification, to limit this disclosure in any way that is not otherwise reflected in the appended claims." ] ]
Patent_15872545
[ [ "MEDICAL KIOSK AND METHOD OF USE", "A medical kiosk designed to provide tele-medicine services, check-in services, and/or prescription services for a user.", "The medical kiosk can include a user video conferencing system that is designed to enable the user to have a real-time or near real-time tele-conference with a medical provider located remotely from the medical kiosk." ], [ "1.A medical kiosk having a modular configuration and designed to provide tele-medicine services to a user, said medical kiosk including a user video conferencing system, said user video conferencing system designed to enable the user to have a real-time or near real-time tele-conference with a medical provider located remotely from said medical kiosk, said user video conferencing system including a first screen, a camera, and a microphone, said first video screen designed to display said medical provider during a video conference between said user and said medical provider, said medical kiosk including a scheduling system that enables a patient to schedule an appointment with a medical provider.", "2.The medical kiosk as defined in claim 1, including a medical kit that includes a plurality of medical devices, two or more of said medical devices selected from the group consisting of a stethoscope, an otoscope, a thermometer, a dermascope, a spirometer, blood pressure cuff, a pulse oximeter, a blood glucometer, an audiometer, and a 3-lead EKG.", "3.The medical kiosk as defined in claim 2, wherein said medical kit includes a lid and a base, said base includes a plurality of compartments, at least two of said compartments each include a different medical device, said lid including a display that enables a user to view a remotely located medical provider.", "4.The medical kiosk as defined in claim 3, wherein said display is in the form of a portable smart device that is removably connected to a cavity in said lid.", "5.The medical kiosk as defined in claim 1, including a mobile device having a housing that includes a plurality of medical devices selected from the group consisting of a stethoscope, an otoscope, a thermometer, a dermascope, a spirometer, blood pressure cuff, a pulse oximeter, a blood glucometer, an audiometer, and a 3-lead EKG.", "6.The medical kiosk as defined in claim 1, wherein one or more medical device panels are used to control and/or display results from one or more medical devices.", "7.The medical kiosk as defined in claim 1, wherein a PHR can be formed or accessed prior to, during, or after a tele-medicine session in the medical kiosk.", "8.The medical kiosk as defined in claim 1, including a mobile device application or network application, said mobile application or network application designed to allow a user various functions on a mobile device or computer, said functions including one or more functions selected from the group consisting of 1) locating an available medical kiosk, 2) scheduling an appointment with the medical kiosk, 3) pre-registering symptoms and/or reasons for visit, 4) set and/or cancel an appointment with the medical kiosk, 5) receiving reminders and/or updates regarding appointments for the medical kiosk, 6) obtaining information about medical kiosk availability, 7) obtaining information about certain medical provider availability, 8) obtaining information about the available medical provider, 9) enabling the selection of a certain medical provider and/or medical provider in a certain field of medicine, 10) obtaining map information, address information and/or hours of operation information regarding a selected medical kiosk, 11) locating the closest kiosk and/or kiosk availability for a certain medical provider and/or medical provider in a certain field of medicine, 12) presubmitting and/or preclearing medical insurance, 13) submitting payment information, 14) receiving information on payment status, 15) receiving information on insurance coverage, 16) receiving appointment reminders and/or updates, 17) receiving prescription information, 18) submitting payment information for medical visit and/or prescription, 19) answer surveys regarding the use of the medical kiosk, and 20) receiving medication reminders.", "9.The medical kiosk as defined in claim 1, including a medication adherence software application that provides one or more functions selected from the group consisting of 1) enabling a patient to speak to a pharmacist, 2) enabling a patient to change the patient's medications alerts, 3) enabling a patient to learn about certain types of medical conditions, 4) enabling a patient to check medication orders status, 5) enabling a patient to check medication delivery status, 6) enabling a patient to refill a prescriptions, 7) enabling a patient to transfer prescriptions to a another location, 8) enabling a patient to obtain information about recommended medication dosages, 9) enabling a patient to obtain information about recommended times to take medications, 10) enabling a patient to obtain information about recommended frequency for taking medications, 11) enabling a patient to obtain information about medications, 12) enabling a patient to obtain information about generic brands available for medications, 13) enabling a patient to request an appointment to speak with a medical provider, 14) enabling a patient to enter information regarding compliance information regarding medication usage by patient, 15) enabling a patient to receive compliance reports for patients regarding medication usage, 16) enabling a patient to pay for the prescription, 17) enabling a patient to select between a generic and non-generic brand of medication, 18) enabling a patient to compare pricing and/or delivery options for various medications, 19) provides reminders for patients to take their medications, 20, monitors and/or generates progress reports to the patient regarding adherence to medication usage, and 21) enrolls a patient in an electronic prescriptions network which sends their prescriptions to their choice of pharmacy.", "10.The medical kiosk as defined in claim 1, including an exterior registration station, said registration station including a user input system that enables the user to enter information about the user prior to having said real-time or near real-time teleconference with a medical provider, said user input system can include one or more components selected from the group consisting of a key pad for identification and/or data entry, keyboard for identification and/or data entry, a touch screen for identification and/or data entry, microphone and/or voice recognition software for identification and/or data entry, a fingerprint scanner for identification and/or data entry, a retina scanner for identification and/or entry, lights, buttons, switches, camera, speakers, microphone, scanner, receiver, transmitter, credit card/debit card or other some other card reader, smart phone or other smart device reader/scanner, finger and/or eye scanner, shelf, printer, storage cavity, service access door, motion sensor, sound sensor, temperature sensor, and logos, said registration station can be used for one or more functions selected from the group consisting of a) allowing patient to enter patient name, b) allowing patient to enter patient address, c) allowing patient to enter patient contact information, d) allowing patient to enter patient age, e) allowing patient to enter patient sex, f) allowing patient to enter patient height, g) allowing patient to enter patient weight, h) allowing patient to enter patient race, i) allowing patient to enter patient language, j) allowing patient to enter patient medical history, k) allowing patient to enter current and/or past medicines used by patient, l) allowing patient to enter information on past medical condition, m) allowing patient to enter reason(s) for visit by patient, n) allowing patient to enter patient current symptoms, o) allowing patient to enter patient's allergies, p) allowing patient to enter patient's ID number and/or password, q) allowing patient to enter patient insurance information, r) allowing patient to enter patient payment information, s) allowing patient to enter consent forms, t) allowing patient to request assistance from a medical attendant, u) allowing patient to enter date and/or time patient desires appointment, v) allowing patient to enter patient's current medical provider, w) allowing patient to request a specific medical provider and/or medical provider specialty, x) providing patient information about the medical kiosk, y) providing patient information on how to use the medial kiosk, z) providing patient information on how to properly input/convey information to the medical kiosk, aa) providing patient instructions and/or interactions with the patient during the inputting/conveying of information by the patient to the medical kiosk, bb) providing patient information on the wait time for the patient's use of the medical kiosk, cc) providing patient a list of patients and/or number of patients waiting to use the medical kiosk, and dd) providing patient information regarding whether the medical kiosk is in use or is available.", "11.The medical kiosk as defined in claim 1, including a display screen that can be used to provide one or more types of information selected from the group consisting of registration information, information input by the user, advertising information, information about the medical kiosk, information about wait time for a medical kiosk, information as to the order of users waiting to use the medical kiosk, information about whether a medical kiosk is available or in use, cable TV shows, satellite TV shows, local broadcast TV shows, infomercials, medical programs, DVD materials, Blu-ray materials, video programs, YouTube programs, and pictures.", "12.The medical kiosk as defined in claim 1, including an interior chamber and a cleaning or sanitizing system to clean or sanitize at least a portion of said interior chamber, said cleaning or sanitizing system including a system selected from the group consisting of a UV system and a mist system.", "13.The medical kiosk as defined in claim 1, including a prescription drug system that includes one or more functions selected from the group consisting of 1) enabling a medical provider to generate electronic prescriptions, 2) enabling a patient to conveniently select and/or order prescription drugs, 3) enabling a patient to choose between name brand and generic drugs, 4) enabling a patient to choose the supply quantity for the prescription, 5) enabling a patient to choose between picking the prescription up at the pharmacy of their choice or mail delivery of the prescription, 6) enabling a patient to enter medical insurance for partial or full payment of the prescription, 7) enabling a patient to enter a credit or debit card information to pay for the prescription, 8) enabling a patient to enter information for mail delivery of the prescription, 9) enabling a patient to enter information to provide automatic reminders to patient regarding refilled and/or follow-up medical visits, 10) enabling a patient to enter information to enable patient to be notified when prescription has been mailed and/or is ready to be picked-up at the pharmacy, 11) enabling a patient to obtain a print out and/or electronic version of the prescription written by the medical provider, 12) enabling a patient to receive information about the issued prescription in printout and/or electronic form, and 13) enabling a patient to select the pharmacy where he/she would like to pick-up the prescription.", "14.A method for providing a real-time or near real-time tele-conference with a medical provider located remotely from a medical kiosk and a patient located at the medical kiosk, said method comprising the steps of: a. providing a medical kiosk; b. providing an attendant application, an appointment application, a provider application, a schedule system, a patient portal, medical adherence application, an administrator application, and/or a provider portal, said attendant application includes software and/or hardware that enables the attendant to 1) monitor, modify and/or cancel existing appointments for a medical kiosk, 2) monitor whether a patient requires assistance, 3) monitor and/or assistant a patient during registration with the medical kiosk, 4) provide procedures and/or check lists for the medical assistant, and/or 5) provide information on the status of the medical kiosk, said attendant application can include one or more functions selected from the group consisting of a) displaying one or more appointment fields of a patient, said appointment fields can include one or more fields selected from the group consisting of time of appointment, patient name, medical provider name, status of appointment and action of attendant, b) checking-in a patient, c) cancelling and/or rescheduling an appointment, d) entering notes about a visit, e) entering notes about a canceled and/or rescheduled visit, f) viewing notes from a medical provider about a patient, g) printing a visit summary, h) allowing the medical attendant to associate an emergency clean-up with a patient appointment, i) allowing medical assistant to view appointment information, j) allowing medical assistant to validate patient IDs, k) allowing medical assistant to validate patient insurance, l) allowing medical assistant to reschedule or cancel an appointment, m) allowing medical assistant to perform the sanitization process for the medical kiosk, n) allowing medical assistant to select the patient records, o) allowing medical assistant to enter in and/or scan ID and/or insurance information, p) providing notice of instructions and/or policies to be given to a patient, q) allowing medical assistant to update patient information, r) allowing medical assistant to enter payment and/or copay information and/or payments for the patient visit, s) displaying a list of sanitation protocols and/or procedures, and t) allowing medical assistant to activate automatic sanitation process, said patient appointment application can include one or more functions selected from the group consisting of 1) enabling a patient to identify themselves as a new and/or returning patient, 2) enabling a patient to schedule a new appointment, verify a previously confirmed appointment and/or cancel an appointment, 3) welcoming a patient that has already scheduled an appointment, 4) providing the patient with a privacy policy associated with the use of the medical kiosk, 5) providing the patient with terms of service policy associated with the use of the medical kiosk, 6) requesting information as to why the patient is using the patient registration system, 7) requesting the patient to enter a password, phone number, pin number, name, email address, address, date or birth and/or sex to identify the patient, 8) requesting the patient to verify if the patient is at least a certain age, 9) requesting the patient to identify one or more symptoms that the patient is experiencing in which the patient is seeking medical assistance, 10) requesting the patient to answer one or more follow-up questions after the patient enters the one or more symptoms, 11) informing the patient to seek an in-person visit by a medical provider after the patient has identified one or more symptoms that the patient is experiencing, 12) requesting the patient to identify one or more known allergies of the patient, 13) requesting the patient to identify one or more known medical conditions of the patient, 14) requesting the patient to identify one or more past medical procedures that have been performed on the patient, 15) requesting the patient to identify one or more medications the patient is taking, 16) asking the patient if the patient has medical insurance, 17) requesting the patient to enter in the medical insurance information and/or to scan the insurance card, 18) requesting the patient to make a copay based the medical insurance or to fully pay for the medical visit, 19) allowing the patient to request assistance, 20) listing one or more days and/or times that the medical kiosk is available for use by the patient, 21) verifying all of the required information and optional payment has been made by the patient by displaying information on a screen, printing out verification for the patient, emailing verification to patient, texting verification to the patient and/or leaving a voicemail of verification for the patient, 22) allowing a patient to update information, 23) storing information in a patient file, 24) navigating the patient through the vitals capture process, 25) navigating the patient through the patient consultation, and 26) navigating the patient through a survey, said provider application is designed to have one or more features selected from the group consisting of a) enabling a medical provider display appointment information, b) enabling a medical provider display patient information, c) enabling a medical provider view and/or modify visit information, d) enabling a medical provider perform the consultation with the patient, and e) enabling a medical provider utilize one or more medical devices in the medical kiosk, said provider application can include one or more functions selected from the group consisting of 1) enabling the medical provider to view appointments that have been completed by the medical provider or are in progress for a certain day, 2) enabling the medical provider to view appointments that have been made for a future time, 3) enabling the medical provider to display one or more types of patient appointment information, said patient appointment information including information selected from the group consisting of time of appointment, patient names, status of appointment, patient started the registration process but has not yet been approved for payment, patient has been checked-in, appointment has started and vitals are being collected, vitals have been collected and the video consultation is in-progress, video consultation has been completed and medical provider completion is pending, and appointment has been completed, 4) enabling the medical provider to display a record about a patient, such record information selected from the group consisting of patient name, patient date of birth, patient sex, patient symptoms, patient medical conditions, date of last visit, diagnosis, allergies, medications, prior visit record of patient, and medical records of patient, 5) enabling the medical provider to notify the medical attendant that the patient requires assistance, 6) enabling the medical provider to limit access to a patient's information, 7) enabling the medical provider to refuse an appointment that has been created for the medical provider, 8) enabling the medical provider to begin the conference with the patient once the patient is ready in the medical kiosk, 9) enabling the medical provider to view the patient on the medical provider's screen, 10) enabling the medical provider to cause an end to the consultation with the patient, 11) allowing the medical provider to view the patient records, including the vitals capture process that has occurred or is occurring in the medical kiosk, 12) enabling the medical provider to modify a patient's record, 13) enabling the medical provider add and/or remove medication, medical conditions, allergies and/or symptoms information in the patient's record, 14) enabling the medical provider to enter notes about a patient, diagnoses for a patient, and/or follow-up care for a patient, 15) enabling the medical provider to control access to and/or activate one or more medical devices in the medical kiosk, 16) enabling the medical provider to view the results from the use of one or more medical devices that have been used by the patient, 17) enabling the medical provider to create a visit summary for a patient, 18) enabling the medical provider to create a prescription for a patient, 19) enabling the medical provider to provide one or more visit documents and/or other types of documents to the patient, 20) enabling the medical provide to contact another medical provide and optionally allow the primary medical provider to view the other medical provider on the provider screen and/or enable the other medical provider to be viewed by the patient, 21) enabling the medical provider to engage a translator to facilitate communication between the patient and medical provider, and 22) enabling the medical provider to contact a third party to obtain information about and/or authorization for a patient using the medical kiosk, said scheduling system can include one or more functions selected from the group consisting of 1) enabling a patient to select a particular medical provider, 2) making an appointment on a medical kiosk at a particular time and place, 3) enabling a patient to select a medical provider or type of medical provider based on the particular need of the patient, 4) locating available locations of medical kiosks, 5) enabling a patient to enter information about the patient, 6) checking past, current and/or future appointments of the patient regarding use of the medical kiosk, 7) entering a partial or full payment for use of the medical kiosk, 8) entering medical insurance information, 9) making payment information, 10) enabling a patient to request assistance, 11) enabling a patient to enter consents and/or consent forms, and 12) enabling the patient to receive reminders about the appointment, said patient portal including one or more functions selected from the group consisting of 1) allowing a patient to locate an available medical kiosk, 2) allowing a patient to schedule an appointment with the medical kiosk, 3) allowing a patient to pre-register symptoms and/or reasons for visit, 4) allowing a patient to set and/or cancel an appointment with the medical kiosk, 5) allowing a patient to receive reminders and/or updates regarding appointments for the medical kiosk, 6) allowing a patient to obtain information about medical kiosk availability, 7) allowing a patient to obtain information about certain medical provider availability, 8) allowing a patient to obtain information about the available medical provider, 9) allowing a patient to enable the selection of a certain medical provider and/or medical provider in a certain field of medicine, 10) allowing a patient to obtain map information, address information and/or hours of operation information regarding a selected medical kiosk, 11) allowing a patient to locate the closest kiosk and/or kiosk availability for a certain medical provider and/or medical provider in a certain field of medicine, 12) allowing a patient to presubmit and/or preclear medical insurance, 13) allowing a patient to submit payment information, 14) allowing a patient to receive information on payment status, 15) allowing a patient to receive information on insurance coverage, 16) allowing a patient to receive appointment reminders and/or updates, 17) allowing a patient to receive prescription information, 18) allowing a patient to submit payment information for medical visit and/or prescription, 19) allowing a patient to answer surveys regarding the use of the medical kiosk, and 20) allowing a patient to receive medication reminders, said medical adherence application is designed to reduce medication errors, said medical adherence application including one or more functions selected from the group consisting of 1) reminding patients to take their meds, 2) automatically creating a log when the patient takes their medication, 3) tracking a patient's compliance to taking their medication on time, 4) providing automatic progress reports, 4) referring the patient to a pharmacist to answer any questions and/or for additional consultation, 5) automatically enrolling the patient in a e-script network, which network sends their prescriptions to the pharmacy of their choice, 6) assisting in improving patient outcomes and/or satisfaction, 7) being designed to be used on a screen in the medical kiosk, and/or on a computer screen and/or mobile device, 8) allowing a patient to speak to a pharmacist, 9) allowing a patient to change medication alerts 9) providing information to a patient about various medical condition, 10) allowing the patient to check medication order status, 11) allowing the patient to refill prescriptions, 12) allowing patient to transfer prescriptions to a pharmacy, 13) providing patient with information about recommended dosages of medication, 14) providing information to patient regarding period for taking medications, 15) providing patient with information regarding frequency for taking medications, 16) providing information to patient regarding information about medications, 17) providing information to patient regarding generic brands available for medications, 18) allowing a patient to request an appointment to speak with a medical provider, 19) allowing the patient to enter compliance information regarding medication usage by patient, 20) providing patient with medication alerts, 21) allowing the patient to change medication alerts, 22) allowing the patient to select how information will be sent to patient, and 23) providing the patient with medication guidelines and/or medical plans, said an administrator application allowing a medical administrator to remotely access one or more components of the medical kiosk, said administrator application including one or more functions selected from the group consisting of 1) allowing remote access to one or more medical devices in the medical kiosk, 2) allowing remote access to one or more computers in the medical kiosk, 3) allowing remote access to one or more routers in the medical kiosk, 4) allowing remote access to one or more displays on the medical kiosk, 5) allowing diagnostics to be executed from a remote location on one or more electronic components in the medical kiosk, 6) allowing the rebooting and/or reinitializing from a remote location of one or more electronic components in the medical kiosk, 7) allowing for review of the current and/or past status from a remote location of one or more electronic components in the medical kiosk, 8) allowing remote access to one or more power supplies in the medical kiosk, 9) allowing remote access to one or more servers in the medical kiosk, 10) allowing remote access to one or more hard drives in the medical kiosk, 11) allowing hardware and/or software updates to be remotely sent and/or loaded onto one or more electronic components in the medical kiosk, and 12) allowing software to be loaded onto and/or removed from one or more electronic components in the medical kiosk, said provider portal can include one or more functions selected from the group consisting of 1) allowing a medical provider to access another medical provider, 2) enabling two or more medical providers to be simultaneously viewed and/or heard by the patient in the medical kiosk, 3) enabling the medical provider to switch to a new medical provider such that only the new medical provider is not viewed by the patient in the medical kiosk, and 4) allowing a second medical provider to listen and/or communicate with the patient in the medical kiosk.", "15.The method as defined in claim 14, wherein said medical kiosk has a modular configuration, said medical kiosk having a user video conferencing system, said user video conferencing system designed to enable the user to have a real-time or near real-time tele-conference with a medical provider located remotely from said medical kiosk, said user video conferencing system including a first and second video screens, a camera, and a microphone, said first video screen designed to display said medical provider during a video conference between said user and said medical provider, said second video screen being a touch screen that enables said user to enter information regarding said tele-medicine services.", "16.The method as defined in claim 14, including a mobile device application or network application, said mobile application or network application designed to allow a user various functions on a mobile device or computer, said functions including one or more functions selected from the group consisting of 1) locating an available medical kiosk, 2) scheduling an appointment with the medical kiosk, 3) pre-registering symptoms and/or reasons for visit, 4) setting and/or cancelling an appointment with the medical kiosk, 5) receiving reminders and/or updates regarding appointments for the medical kiosk, 6) obtaining information about medical kiosk availability, 7) obtaining information about certain medical provider availability, 8) obtaining information about the available medical provider, 9) enabling the selection of a certain medical provider and/or medical provider in a certain field of medicine, 10) obtaining map information, address information and/or hours of operation information regarding a selected medical kiosk, 11) locating the closest kiosk and/or kiosk availability for a certain medical provider and/or medical provider in a certain field of medicine, 12) presubmitting and/or preclearing medical insurance, 13) submitting payment information, 14) receiving information on payment status, 15) receiving information on insurance coverage, 16) receiving appointment reminders and/or updates, 17) receiving prescription information, 18) submitting payment information for medical visit and/or prescription, 19) answer surveys regarding the use of the medical kiosk, and 20) receiving medication reminders.", "17.The method as defined in claim 14, wherein said medical kiosk includes a cleaning or sanitizing system to clean or sanitize at least a portion of an interior chamber, said cleaning or sanitizing system including a system selected from the group consisting of a UV system and a mist system.", "18.The method as defined in claim 14, including a medical kit that includes a plurality of medical devices, two or more of said medical devices selected from the group consisting of a stethoscope, an otoscope, a thermometer, a dermascope, a spirometer, blood pressure cuff, a pulse oximeter, a blood glucometer, an audiometer, and a 3-lead EKG.", "19.The method as defined in claim 18, wherein said medical kit includes a lid and a base, said base includes a plurality of compartments, at least two of said compartments each include a different medical device, said lid including a display that enables a user to view a remotely located medical provider, said display is in the form of a portable smart device that is removabley connected to a cavity in said lid.", "20.The method as defined in claim 14, including a mobile device having a housing that includes a plurality of medical devices selected from the group consisting of a stethoscope, an otoscope, a thermometer, a dermascope, a spirometer, blood pressure cuff, a pulse oximeter, a blood glucometer, an audiometer, and a 3-lead EKG.", "21.The method as defined in claim 14, wherein one or more medical device panels are used to control and/or display results from one or more medical devices.", "22.The method as defined in claim 14, wherein a PHR can be formed or accessed prior to, during or after a tele-medicine session in the medical kiosk." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Medical services are traditionally provided to individuals at a doctor's office or medical facility.", "Typically, an individual contacts his/her medical provider when the individual requires some type of medical assistance.", "The medical provider then sets an appointment time and date for the individual to see the medical provider.", "Many times, the time and date of the appointment are inconvenient for the individual.", "Furthermore, the individual seeking medical assistance may desire or need more immediate medical assistance and cannot wait for the time and date set by the medical provider.", "In such situations, the individual goes to the emergency room of a hospital or some type of medical clinic (e.g., Minute Clinic, Take Care Clinic, Urgent Care Clinic, etc.", "), assuming that such clinics are available or convenient to visit.", "In other situations, especially in smaller towns and rural areas, a medical facility may be located many miles away thus making a visit to such a facility very inconvenient.", "As such, many individuals who should seek medical care decide to not seek the advice of medical personnel due to the inconvenience of having to travel large distances to a medical facility.", "The costs associated with visiting a medical provider can be costly depending on the type of insurance, if any, the individual carries.", "When an individual visits the emergency room of a hospital, the medical costs can be substantially higher and insurance coverage may be limited to various types of visits.", "Insurance coverage and the cost of the visit may also vary at various clinics.", "In many communities, clinics are not readily available, thus the individual must either visit the medical provider or go to the hospital.", "Various pharmacy and drug stores have begun offering medical services on their premises.", "These locations generally offer flu shots and very basic medical services, and are typically provided by a nurse practitioner, not a doctor.", "As such, only very limited types of medical services are offered at such locations.", "Also, these locations are not offered in a private environment.", "Generally, the services are provided in a side corridor or partitioned location in the facility.", "In view of the current state of the medical services, there is a need for providing medical services in a more convenient, desirable, timely and cost effective manner." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present invention is directed to a method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals in a convenient, desirable, timely and cost effective manner.", "The novel medical apparatus of the present invention and the novel method for providing medical services, diagnoses, health advice, and/or wellness advice addresses the current deficiencies that exist for providing medical services to individuals.", "In one non-limiting aspect of the invention, there is provided a method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals that includes a remote medical service arrangement wherein a patient can receive various types of medical advice and services remotely from one or more medical providers (e.g., doctor, nurse practitioner, nurse, psychologist, psychiatrist, optometrist, physician assistant, pharmacist, health coach, dietitian, medical assistant, etc.).", "Traditionally, a patient was required to go to a medical facility (e.g., hospital, medical clinic, doctor's office, etc.)", "to personally meet with and be diagnosed by the medical provider.", "The present invention is directed to a method wherein medical services, diagnoses, health advice, and/or wellness advice can be dispensed by a medical provider at a location that is remote from the patient.", "The present invention can be used to provide services in one or more different medical specialties (e.g., Allergology; Andrology; Anesthesia; Angiology; Athletic training; Aviation medicine; Cardiology; Dentistry; Dermatology; Disaster medicine; Emergency medicine; Endocrinology; Family medicine; Gastroenterology; General practice; Medical genetics; Geriatrics; Gerontology; Gynaecology; Hematology; Hepatology; Immunology; Infectious diseases; Intensive care medicine; Internal medicine; Military medicine; Nephrology; Neurology; Nuclear medicine; Obstetrics; Oncology; Ophthalmology; Oral and maxillofacial surgery; Orthopedics; Otolaryngology; Paleopathology; Palliative medicine; Pathology; Pediatrics; Podiatry; Psychiatric specialties; Psychiatry; Pulmonology; Radiology; Rehabilitation medicine; Rheumatology; Serology; Sexual health; Sleep medicine; Space medicine; Sports medicine; Surgery; Toxicology; Transplantation medicine; Tropical medicine; Urology; Wilderness medical emergencies; and/or Wilderness medicine).", "The method and device of the present invention can be used to provide initial screening, treatment, and/or follow-up treatment for a patient.", "The method and device of the present invention can be used in many situations as an alternative for a patient visiting a medical facility or a doctor's office.", "However, it can be appreciated that the device of the present invention could be located in a lobby or special region of a doctor's office or medical facility.", "In one non-limiting arrangement of the present invention, there is provided an audio and/or video link between one or more medical providers located at one or more locations (e.g., medical provider's office, medical provider's home, hospital, etc.)", "and the patient is located at some other location (e.g., shopping mall, shopping center, drug store, grocery store, department store, warehouse store, discount retailer, discount department store, truck trailer, mobile office, mobile home, office space location, home, car, train, boat, cruise line, friend's home, etc.)", "that is remote from the one or more medical providers.", "In essence, the patient can be at any location in which the patient can obtain telephone, satellite, Wi-Fi and/or internet access.", "The novel method of the present invention for providing medical services, diagnoses, health advice, and/or wellness advice enables a medical provider to provide medical services, diagnoses, health advice, and/or wellness advice to patients without the patient having to physically visit the medical provider and/or having to go to the medical provider's office or place of work.", "As can be appreciated, the audio and/or video link that is used by the medical provider can enable the medical provider to provide medical services, diagnoses, health advice, and/or wellness advice at a single remote location or a plurality of remote locations.", "When the audio and/or video link enables the medical provider to provide medical services, diagnoses, health advice, and/or wellness advice to a plurality of remote locations, a single medical provider and/or a plurality of medical providers can be used to provide medical services, diagnoses, health advice, and/or wellness advice to patients that are located at a variety of different remote locations.", "When a plurality of medical providers is used, the medical providers can be located at the same or different locations.", "As can be appreciated, the novel method for providing medical services allows for more flexibility for a patient to obtain medical services, diagnoses, health advice, and/or wellness advice.", "The site at which the patient obtains the medical services, diagnoses, health advice, and/or wellness advice via the method and device of the present invention can be located in a) non-traditional locations that are more convenient to a patient (e.g., shopping mall, public park, department store, retail store, grocery store, museum, office building, business office, business facility, big box stores, government base or facility, drug stores, boat, airplane, train, home, friend's home, car, patient's workplace, etc.", "), and/or b) traditional locations (e.g., doctor's office, hospital, urgent care facility, etc.)", "so as to provide easier and/or more convenient access to such medical services, diagnoses, health advice, and/or wellness advice.", "The geographic location for the device of the present invention can be in a single residence, a single business building, a single neighborhood, multiple neighborhoods, a single town or city, multiple towns or cities, a single state or province, multiple states or provinces, a single country, multiple countries, space, domestic and/or international waterways, etc.", "The novel method can also be used to provide medical services, diagnoses, health advice, and/or wellness advice at standard times (e.g., 9 am-5 pm Monday through Friday, etc.)", "and/or non-standard times (e.g., early morning hours, evening hours, weekend hours, holiday hours, etc.)", "to enable a patient to obtain medical services, diagnoses, health advice, and/or wellness advice at times that are more convenient and timely to the patient.", "In another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be used to provide a variety of different medical services, diagnoses, health advice, and/or wellness advice.", "Non-limiting examples of such medical services, diagnoses, health advise, wellness advise and/or medical conditions that can be identified, treated and/or addressed include, but are not limited to, acid reflux; hypertension management; allergies; Athlete's Foot; acne; mental health counseling; wellness counseling; asthma; cold sores; vaccinations; arthritis; bronchitis; impetigo; wellness coaching; weight loss; eating disorders; bladder infections; insect stings; allergic reactions; rashes; hemorrhoids; minor burns; health risk management; migraine headaches; common colds; virus infections; bacterial infections; minor skin infections; chronic disease management; coughs; Poison Oak/Ivy; diarrhea; rashes; diabetes; ringworm; lice; ear infections; sties; flu; fever; gout; headache (minor); pink eye; sinus infections; sore throat; ear infections; cramps; STDs; strep throat; throat infections; feeding problems for newborns; vomiting; teething; gastrointestinal problems; anxiety; depression, formula advice for newborns; concussion; head injuries; bone fractures; sprains; hair loss; alopecia; eye infections; urinary tract infections; constipation; appendicitis; pharyngitis; medication therapy management; acid reflux disease; acne; alcohol abuse; allergies; antisocial personality disorder; attention deficit disorder; altitude sickness; Alzheimer's Disease; andropause; anger management; anorexia nervosa; arthritis; Aspergers Syndrome; asthma; autism; back pain; bad breath (halitosis); baldness; bedwetting; bipolar disorder; bladder cancer; body dysmorphic disorder; bone cancer; brain cancer; breast cancer; brain tumors; brain injury; bronchitis; burns; bursitis; cancer; canker sores; Carpal Tunnel Syndrome; celiac disease; cervical cancer; cholesterol; chronic obstructive pulmonary disease; colon cancer; congestive heart failure; cradle cap; Crohn's Disease; dandruff; deep vein thrombosis; dehydration; depression; diabetes; diaper rash; disabilities; diverticulitis; Down Syndrome; drug abuse; smoking cessation; dysfunctional uterine bleeding; dyslexia; ear infections; ear problems; eating disorders; eczema; endometriosis; enlarged prostate; epilepsy; erectile dysfunction; eye problems; fibromyalgia; fracture; gallbladder disease; gallstones; generalized anxiety disorder; genital herpes; genital warts; glomerulonephritis; gonorrhea; gout; gum diseases; gynecomastia; head lice; headache; hearing loss; heart attacks; heart disease; heartburn; heat stroke; heel pain; hemorrhage; hemorrhoids; hepatitis; herniated discs; hiatal hernia; HIV/AIDS; hives; hyperglycemia; hyperkalemia; hypertension; hyperthyroidism; hypothyroidism; infectious diseases; infectious mononucleosis; influenza; infertility; insulin dependent diabetes mellitus; iron deficiency anemia; irritable bowel syndrome; irritable bowel syndrome; itching; joint pain; juvenile diabetes; juvenile rheumatoid arthritis; kidney diseases; kidney stones; leukemia; liver cancer; lung cancer; Mad Cow Disease; malaria; medication management; melena; memory loss; menopause; mesothelioma; migraine; miscarriages; mucus in stool; multiple personality disorder; multiple sclerosis; muscle cramps; muscle fatigue; muscle pain; nail biting; narcissistic personality disorder; neck pain; obesity; obsessive compulsive disorder; osteoarthritis; osteomyelitis; osteoporosis; ovarian cancer; ovarian cyst; pain; pain management; panic attack; Parkinson's Disease; peripheral artery disease; personality disorders; pervasive developmental disorder; Peyronie's Disease; phobias; pink eye; polio; pneumonia; post nasal drip; post-traumatic stress disorder; premature baby; premenstrual syndrome; prostate cancer; psoriasis; reactive attachment disorder; renal failure; restless legs syndrome; rheumatoid arthritis; rheumatic fever; ringworm; rosacea; rotator cuff; scabies; scars; sciatica; schizophrenia; sexually-transmitted disease; sinus infections; skin cancer; skin rash; sleep apnea; sleep disorders; smallpox; snoring; social anxiety; staph infection; stomach cancer; strep throat; Sudden Infant Death Syndrome; sunburn; syphilis; systemic lupus erythematosus; tennis elbow; termination of pregnancy; testicular cancer; tooth decay; tuberculosis; ulcers; urinary tract infection; varicose veins; vertigo; warts; Williams Syndrome; yeast infection; Yellow Fever, etc.", "As can be appreciated, other or additional types of medical services and/or health care services can be provided.", "The medical services and/or health care services that can be provided can include, but are not limited to, 1) providing advice and/or recommendations about a medical condition, 2) diagnosing and/or treating a medical condition, 3) providing referral services for a medical condition, 4) prescribing medicine for a medical condition, 5) periodically monitoring a medical condition, 6) providing follow-up checks for a medical condition, 7) providing routine check-up services, 8) providing advice, counseling, and/or recommendations about medical and/or health matters, 9) providing a course of treatment for a medical condition, 8) providing health counseling, 10) providing health information, 12) providing wellness counseling, and/or 13) providing wellness information.", "As can be appreciated, other or additional services can be provided to the patient.", "In essence, any type of medical condition, medical concern, health concern, wellness concern, etc.", "can be addressed in whole or in part by the novel method and apparatus for providing medical services of the present invention.", "Hereinafter, these services will be collectively referred to as medical services.", "As can be appreciated, the type of services provided to a patient will depend on the specific medical condition, medical concern or need, wellness concern or need, and/or health concern or need of the patient.", "In many instances, the medical provider will be able to diagnose, address, advise, consult and/or treat the specific medical condition or need, medical concern or need, wellness concern or need, health concern or need, etc.", "of the patient.", "In some instances, the specific medical condition or need, medical concern or need, wellness concern or need, health concern or need, etc.", "of the patient may be too complicated and/or too complex to address via an audio and/or video link; thus, the medical provider in such situations may need to refer the patient to a hospital, a doctor's office, counselor, psychiatrist/psychologist, medical specialist, health professional, dietician, rehabilitation facility, or a traditional medical clinic for further counseling, treatment and/or diagnosis, or some other location or professional that can address the patient's needs and/or requirements.", "In still another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of a medical kiosk to enable the patient to conveniently communicate with one or more medical providers.", "One or more medical kiosks can be used in the present invention.", "Generally, a plurality of medical kiosks which are located at one or more locations are used in the method of the present invention; however, it can be appreciated that a single medical kiosk can be used in accordance with the present invention.", "Typically, one or more medical providers provide services to one or more medical kiosks.", "The size, shape, configuration and look of the medical kiosk are non-limiting.", "The medical kiosk, when in the form of a personal medical kiosk, may merely be in the form of a tablet, laptop, smart phone, etc., that is being used in any location that the patient desires.", "The medical kiosk, when in the form of a free standing structure, can be configured in a variety of ways.", "For example, the medical kiosk can take the form of a room, partition area, etc.", "that includes laptop computer, desktop computer, tablet, etc.", "Alternatively, the medical kiosk, when in the form of a free-standing structure, can include an enclosure that is designed to enable a patient to enter the enclosure and to communicate with the medical provider.", "In one non-limiting embodiment of the invention, the medical kiosk provides a private or semi-private environment for a patient to communicate with one or more medical providers that are located remotely from the medical kiosk.", "The medical kiosk can include an enclosure that is designed to enable a patient to enter the enclosure and to communicate with the medical provider in a private or semi-private manner while in the enclosure of the medical kiosk.", "The size, shape and configuration of the enclosure of the medical kiosk are non-limiting.", "In another and/or alternative non-limiting arrangement, the medical kiosk includes one or more walls that form all or a portion of the sides of the enclosure of the medical kiosk.", "The enclosure may include one or more doors or entry points to enable a patient to enter and/or exit the enclosure.", "In another and/or alternative non-limiting arrangement, the medical kiosk typically includes a floor and/or a ceiling.", "The ceiling, when included, can include a portion that is partially or fully transparent; however, this is not required.", "In another and/or alternative non-limiting arrangement, the medical kiosk can have a modular configuration to enable the parts of the medical kiosk to be set up in various configurations to enable the medical kiosk to be used in various types of spaces and/or to be set up in various types of configurations.", "The medical kiosk can be formed of any number of materials (e.g., plastic, foam, metal, wood, composite materials, fiber board, etc.).", "The one or more walls of the medical kiosk can be designed to be interchangeable to enable the door, when used, to be positioned on various locations on the medical kiosk; however, this is not required.", "The medical kiosk can include a floor and/or ceiling to provide for increased privacy for the patient when the patient is inside the room, cavity or enclosure of the medical kiosk; however, this is not required.", "The medical kiosk can include one or more tables, ledges, benches, and/or seats in the interior and/or exterior of the medical kiosk; however, this is not required.", "Such table, ledge, bench, and/or seat, when used, can be designed to be connected in multiple locations on the exterior and/or interior of the medical kiosk; however, this is not required.", "The modular configuration of the medical kiosk can be such that it can be easily assembled and/or disassembled so that the medical kiosk can be easily brought into a location and easily set up, and/or be easily removed from a location; however, this is not required.", "In yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of a medical kiosk in the form of a personal medical kiosk to enable the patient to conveniently communicate with one or more medical providers.", "The size, shape, configuration and look of the personal medical kiosk are non-limiting.", "In one non-limiting embodiment of the invention, the medical kiosk, when in the form of a personal medical kiosk, includes a personal computer interface (e.g., laptop computer, desktop computer, tablet, smart phone, notepads, home PC, smart TVs, and/or entertainment console [e.g., Xbox systems, PS3, PS4, Apple TV, Amazon Fire TV, etc.]", "etc.)", "that can be used by a user to create a video connection with a remotely-located medical provider.", "The personal medical kiosk also includes an interface that enables the personal computer interface to communicate with one or more medical devices that are to be used by the patient.", "In one non-limiting arrangement, the personal medical kiosk is designed to enable a patient to communicate with the medical provider in a private or semi-private manner (e.g., patient's home, car, friend's home, boat, hotel, etc.).", "In still yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of a medical kiosk that includes one or more data input terminals; however, this is not required.", "The one or more data input terminals can be located on one or more locations on the exterior of the medical kiosk; however, this is not required.", "Alternatively or additionally, the one or more data input terminals can be located on one or more locations in the interior or enclosure of the medical kiosk; however, this is not required.", "Alternatively or additionally, the one or more data input terminals can be in the form of a laptop computer, desktop computer, tablet, smart phone, etc.", "The one or more data input terminals can include a video display to display information regarding identification and/or data entry, a camera and/or video camera used to collect information for identification and/or data entry, a keypad or keyboard for identification and/or data entry, a touch screen for identification and/or data entry, microphone and voice recognition software for identification and/or data entry, fingerprint scanner for identification and/or data entry, retina scanner for identification and/or data entry, and/or face and/or body scanners for identification and/or data entry.", "As can be appreciated, other or additional devices can be included on the medical kiosk to display and/or obtain information regarding identification and/or data entry.", "The medical kiosk can be used by the patient to enter/convey basic information about the patient.", "Such information includes, but is not limited to, a) patient name, b) patient address, c) patient contact information (e.g., home address, work address, phone number, email address, pager number, work number, etc.", "), d) patient age, e) patient sex, f) patient height, g) patient weight, h) patient medical history, i) current medicines used by patient, j) reason(s) for visit by patient, k) patient current symptoms, l) patient insurance information, m) patient payment information, n) patient's current doctor, o) guardian or patent information, p) next of kin information, q) desired medical provider for visit, r) allergy information, s) information about a prior visit, t) medical records information, and/or u) pharmacy information.", "As can be appreciated, other or additional information can be inputted/conveyed by the patient.", "In another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medial kiosk that can be designed to provide information to the patient prior to and/or during the inputting/conveying of information by the patient to the medical kiosk.", "In one non-limiting embodiment of the invention, the medical kiosk can include audio and/or visual instructions and/or displays used to provide a) information about the medical kiosk, b) how to use the medial kiosk, c) how to properly input/convey information to the medical kiosk, d) provide instructions and/or interactions with the patient during the inputting/conveying of information by the patient to the medical kiosk, e) the wait time for the patient's use of the medical kiosk, f) a list of patients waiting to use the medical kiosk, g) available medical providers, h) types of medical issues that can be addressed by use of the medical kiosk, i) insurance providers that can be used to partially or fully pay for a visit in the medical kiosk, j) payment options for use of the medical kiosk, k) information regarding when the medical kiosk is available in the future, and/or l) information regarding whether the medical kiosk is in use or is available.", "In another and/or alternative non-limiting embodiment of the invention, the medical kiosk can include light, sound indicators, and/or digital displays to provide information regarding whether the medical kiosk is in use or is available; however, this is not required.", "In still another and/or alternative non-limiting embodiment of the invention, the medical kiosk can include a notification system to a patient that the medical kiosk is available or will soon be available; however, this is not required.", "Such a notification can be sent via email, text, phone, pager, internet, digital display, etc.", "Such notification system can be useful when the medical kiosk is not currently available to the patient.", "The patient can input the information into the medical kiosk and then go home, run other errands, etc., and then be later notified when the medical kiosk is available or will soon be available.", "The medical kiosk and/or notification system can also be used to inform the patient when and/or where other medical kiosks are available; however, this is not required.", "This service, when available, can be used to inform the patient that a nearby medical kiosk has a shorter wait period or is currently available, thus providing the patient with the option of traveling to another available medical kiosk instead of waiting for the current medical kiosk to become available; however, this is not required.", "This service, when available, can also be used to inform the patient when a prescription is ready for pickup and/or for conveying prescription information to the patient; however, this is not required.", "This service, when available, can also be used to inform the patient when a follow-up visit is due and/or scheduled; however, this is not required.", "As can be appreciated, the notification system can be used for other or additional services.", "In still another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a scheduling system for use of the medical kiosk.", "The scheduling system allows a patient to schedule an appointment with a medical provider when the patient uses the medical kiosk.", "The scheduling system can be used to 1) enable a patient to select a particular medical provider, 2) make an appointment on a medical kiosk for a particular time and place, 3) enable a patient to select a medical provider or type of medical provider based on the particular need of the patient (e.g., select a medical provider that specializes in dermatology to address a rash issue on the patient, select a medical provider that specializes in orthopedics to address a sports injury to the knee, etc.", "), 4) locate available locations of medical kiosks, 5) enable a patient to enter basic information about the patient, 6) check a past, current or future appointment of the patient regarding use of the medical kiosk, 7) enter a partial or full payment for use of the medical kiosk, 8) enter medical insurance information, etc.", "The scheduling system can be designed to be accessed by a patient on a data entry device on a medical kiosk, via a computer or phone or smart device, and/or by phone.", "The scheduling system can optionally be designed to enable a patient to request assistance if there a question regarding the use of the scheduling system.", "In yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include one of more software applications (e.g., Patient Registration Application, Attendant Application, Patient Appointment or Registration Application, Medical Provider Application, Administrator Application, Patient Portal, Provider Portal, etc.", "); however, this is not required.", "For example, the Patient Appointment or Registration Application can include the screens the patient navigates through during the patient registration process; however, this is not required.", "These screens can optionally appear on the registration station of the exterior of the medical kiosk.", "The Attendant Application can include screens through which the medical attendant, when used, navigates during the patient appointment; however, this is not required.", "These screens can optionally appear on a laptop, computer screen, tablet, smart phone, etc.", "located with the medical attendant and/or at or near the attendant desk on the exterior of the medical kiosk; however, this is not required.", "The Patient Appointment or Registration Application can include screens through which the patient navigates during the patient consultation; however, this is not required.", "These screens can optionally appear on the medical provider screen and/or patient screen in the interior of the medical kiosk.", "The Provider Application can include the screens through which the medical provider navigates during the patient appointment; however, this is not required.", "These screens can optionally appear on the medical provider's computer, laptop, tablet, smart phone, etc.", "at his/her remote location.", "As can be appreciated, other or additional software and/or hardware application can be used with the medical kiosk of the present invention.", "The Patient Appointment or Registration Application can allow the patient to select a language to be displayed (e.g., English, Spanish, German, French, Chinese, Japanese, etc.", "); however, this is not required.", "In another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of a Patient Appointment or Registration Application; however, this is not required.", "The Patient Appointment or Registration Application can include one or more navigational buttons (e.g., Back, Next, Cancel, Request Assistance, etc.)", "for use by the patient during the registration process; however, this is not required).", "For example, the Back button can be designed to allow the patient to return to the previous screen, the Next button can be designed to allow the patient to proceed to the next screen, the Cancel button can be designed to allow the patient to cancel a process and return to the beginning of the process (e.g., patient receives a pop-up box asking them if they are sure they want to cancel and return to the beginning of the process.", "They may choose “Yes” or “No”.", "“Yes” returns them to the beginning of the process.", "“No” returns them to the screen they were on when they hit the Cancel button), and the Request Assistance button can be designed to allow the patient to request assistance from the Attendant (e.g., the patient can receive a pop-up box notifying them that the attendant will be with them in a moment and the attendant also receive a notice that the patient requires assistance.", "The notice provided to the attendant can optionally be color coded and/or generate a certain sound to indicate the source and/or seriousness of the request by a patient and/or medical provider, etc.).", "The Patient Appointment or Registration Application can include a process through which the patient identifies themselves as a new and/or returning patient and either schedules an appointment at one or more medical kiosks or registers for an existing appointment at one or more medical kiosks.", "The medical kiosk can optionally be staffed by a medical assistant or attendant at all times.", "During the patient registration process, the medical assistant or attendant responsibilities, when used, can include welcoming the patient, offering assistance, validating patient identification, initiating/finalizing the patient consultation, and/or completing the sanitization process.", "As can be appreciated, the medical assistant or attendant can have other or additional responsibilities (e.g., check operation of medical kiosk, report a malfunction of a medical kiosk, monitor appointment status of medical kiosk, assist the patient in the medical kiosk, reload software, etc.).", "As can be appreciated, the personal medical kiosk generally does not include a medical assistant and/or attendant.", "The Patient Appointment or Registration Application can optionally be designed to enable a patient to register and schedule appointments through one or more methods (e.g., on-line registration, calling a registration location, visiting a medical kiosk, etc.).", "During the patient registration process, the Patient Appointment or Registration Application can include scheduling software that provides a scheduling system for a patient to register with one or more medical kiosks.", "The scheduling system can be designed to be accessed by a patient on a data entry device on a medical kiosk, via a computer, satellite, phone, smart TV, entertainment systems, or any other device that can access a phone signal, satellite signal and/or the internet.", "The patient registration system can be designed to 1) schedule a new appointment for a patient, 2) schedule an appointment for a returning patient, and/or 3) welcome a patient that has already scheduled an appointment.", "In one non-limiting arrangement, the patient registration system generally asks if the patient is a returning patient, a new patient or if the patient requires assistance.", "The patient registration system generally provides the patient with a privacy policy associated with the use of the medical kiosk; however, this is not required.", "When a privacy policy is presented to the patient, the patient generally must acknowledge or accept the privacy policy before the patient can proceed further with the registration process; however, this is not required.", "The patient registration system generally provides the patient with terms of service policy associated with the use of the medical kiosk; however, this is not required.", "When the terms of service policy is presented to the patient, the patient generally must acknowledge or accept the terms of service policy before the patient can proceed further with the registration process; however, this is not required.", "The patient registration system generally asks why the patient is using the patient registration system (e.g., Medical kiosk tour, Medical kiosk demo, Medical kiosk payment demo, check-in for a medical visit, etc.).", "The patient registration system generally asks the patient to enter a password, phone number, pin number, name, email address, address, date of birth, sex, or the like to identify the patient; however, this is not required.", "The patient registration system generally asks the patient to verify if the patient is at least a certain age (e.g., at least two years old, etc.)", "before medical services can be provided by the medical kiosk; however, this is not required.", "The patient registration system generally asks the patient to identify one or more symptoms (e.g., body aches, chest congestion, cough, earache or pain, eye itching or swelling, fatigue, fever, headache, nasal congestion, nausea, pink eye, shortness of breath, skin rash, urinary problems, constipation, wheezing, cramps, pulled muscle, stomach pains, indigestion, gas problems, swelling, etc.)", "that the patient is experiencing for which the patient is seeking medical assistance; however, this is not required.", "The patient registration system may optionally ask one or more follow-up questions after the patient enters the one or more symptoms and/or may inform the patient to seek an in-person visit by a medical provider; however, this is not required.", "The patient registration system may optionally ask the patient to identify one or more known allergies of the patient (e.g., none, amoxicillin, aspirin, bee stings, cosmetics, eggs, fish, hay fever, hives, latex, metals, milk, mold, MSG, nuts, drugs, penicillin, pets, poison ivy, shellfish, soy, sulfa, sun, wheat, other, etc.", "); however, this is not required.", "The patient registration system may optionally ask the patient to identify one or more known medical conditions of the patient (e.g., none, alcoholism, arthritis, asthma, breast cancer, chronic ear infections, diabetes, emphysema, enlarged prostate, glaucoma, heart attack, high blood pressure, high cholesterol, liver problems, cancer, skin cancer, stroke, thyroid problems, tuberculosis, other, etc.", "); however, this is not required.", "The patient registration system may optionally ask the patient to identify one or more past medical procedures that have been performed on the patient; however, this is not required.", "The patient registration system may optionally ask the patient to identify one or more medications the patient is taking; however, this is not required.", "The patient registration system may optionally ask the patient if the patient has medical insurance; however, this is not required.", "If medical insurance is inquired about and the patient indicates that he/she has medical insurance, the patient registration system may optionally ask the patient to enter in the medical insurance information (e.g., insurer name, ID number, policy number, etc.)", "and/or to scan the insurance card; however, this is not required.", "The patient registration system may optionally ask the patient to make a copay based on the medical insurance or to fully pay for the medical visit; however, this is not required.", "Such payments, if any, can be by cash, check, debit card, credit card, smart device, etc.).", "For debit and credit cards and smart devices, the medical kiosk may include a card reader or scanner or RFID system, and/or may include a key pad to enter the charge or credit information; however, this is not required.", "A medical assistant or attendant of the medical kiosk can optionally assist the patient with the payment of services and/or with any other check-in step of the patient registration system; however, this is not required.", "For example, the patient registration system may include a button or other request arrangement to signal to a medical assistance or attendant, if used, that the patient needs assistance with one or more steps of the registration process; however, this is not required.", "Once the patient is registered, the patient registration system will list one or more days and/or times that the medical kiosk is available for use by the patient; however, this is not required.", "The time intervals can be spaced by a certain time period (e.g., every twenty minutes, every thirty minutes, etc.", "); however, this is not required.", "The patient registration system can verify that an appointment has been made by the patient once all of the required information and optional payment has been made; however, this is not required.", "Such verification can be merely displayed on the patient registration system, printed out for the patient, emailed or texted to the patient, or left on a voicemail of the patient; however, this is not required.", "If the patient is a returning patient, the patient may merely need to enter the ID information to access the information that the patient had previously entered and then optionally update such information; however, this is not required.", "A previous patient may be asked about the new visit (e.g., follow-up, new symptoms, etc.", "); however, this is not required.", "The previous patient may optionally be asked to update insurance information, reenter insurance information, etc.", "and then optionally make the required copay or full payment.", "If the returning patient is merely returning to a scheduled appointment, the patient may need to enter the ID information and verify that the patient is present and is checked-in or cancelling the scheduled appointment; however, this is not required.", "A medical assistant or attendant can optionally provide assistance to a patient during any step of the check-in or registration process or recheck-in process; however, this is not required.", "The information entered and/or scanned regarding the patient can optionally be saved to a file for current and/or later access by the patient, medical provider, medical assistant, etc.", "; however, this is not required.", "Such stored information is generally saved on a database, server, etc.", "that is located remote to the medical kiosk; however, this is not required.", "In still another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of one or more medical assistants or attendants with the medical kiosk; however, this is not required.", "Generally, medical assistants or attendants are used with a personal medical kiosk.", "In one non-limiting embodiment of the invention, the medical kiosk can have one or more attendants assist a patient during the use of the medical kiosk (e.g., assist in check-in procedures, assist check-out procedures, assist in entering/exiting the medical kiosk, answering questions about the medical kiosk, assist the patient about the use of the kiosk, assist the patient during examination of the patient by the medical provider, assist in maintaining privacy/security of a patient while using the medical kiosk, assist user during payment of medical services, assist user in obtaining a prescription, assist in answering general questions about the medical kiosk, assist the remote medical provider during the examination of the patient, assist in using one or more medical devices on the patient, cleaning the medical kiosk, maintaining the systems of the medical kiosk, resetting the medical kiosk for use by another patient, assist in processing of payments and/or insurance information of a patient, monitor proper use of the medical kiosk, etc.", "); however, this is not required.", "Such attendant, when used, can be a medical provider or non-medical provider.", "The assistant may or may not have any formal medical education.", "The one or more attendants, when used, can also or alternatively clean and/or sanitize various regions of the medical kiosk prior to and/or after being used by a patient and/or set up the medical kiosk for a new user; however, this is not required.", "For example, prior to and/or after one or more patients have entered the medical kiosk, the one or more attendants can clean/sanitize one or more exterior surfaces and/or regions of the medical kiosk (e.g., medical kiosk door, medical kiosk check-in terminal, medical kiosk desk top, medical kiosk exterior walls, medical kiosk touch screen, medical kiosk monitors, seating/tables in waiting area near medical kiosk, etc.", "); however, this is not required.", "In an another and/or additional example, prior to and/or after one or more patients have entered the medical kiosk, the one or more attendants can clean/sanitize one or more interior surfaces of the medical kiosk (e.g., medical kiosk door, medical kiosk floor, medical kiosk bench, medical kiosk chair, medical kiosk user terminal, medical kiosk interior desk top, medical kiosk interior walls, medical kiosk touch screen, medical kiosk monitors, medical kiosk instrument doors, medical devices/instruments used by and/or touched by user when in the medical kiosk, any other surface in the interior of the medical kiosk, etc.", "); however, this is not required.", "In still another and/or additional example, prior to and/or after one or more patients have entered the medical kiosk, the one or more attendants can set up the medical kiosk for a user (e.g., clean/sanitize interior surfaces of medical kiosk; clean/sanitize medical devices/instruments used and/or touched by a prior user; reposition medical devices/instruments into device storage areas; replace disposable components on medical devices/instruments; replenish paper in a printer; clear a paper jam in a printer; replace batteries for one or more electronic components; close medical device/instrument compartments doors in the medical kiosk; reset user touch screen for next user in the medical kiosk; fix, repair and/or replace non-operating, damaged or broken medical devices/instruments in the medical kiosk; fix, repair and/or replace electronic components, computers, fans, light bulbs, UV bulbs, UV devices, etc.", "in the interior and/or exterior of the medical kiosk; refill cleaning and/or sanitizing fluid; etc.", "); however, this is not required.", "In yet another and/or additional example, the one or more attendants can be used to assist one or more users in the medical kiosk.", "Generally, such assistance will occur only after requested by the user in the medical kiosk or by the medical provider that is assisting the user while in the medical kiosk; however, this is not required.", "For instance, the one or more attendants can assist a user in the medical kiosk if the one or more attendants hear a verbal request from the user, receive notice (e.g., light indicator activated by user, sound indicator activated by user, hear user talking via a speaker to attendant, hear user talking through walls of medical kiosk, receive a notice from the medical provider [e.g., phone call, email, light indicator, etc.", "], etc.", "); however, this is not required.", "The one or more medical assistants can be positioned at a desk or table that is positioned adjacent to or connected to the exterior of the medical kiosk; however, this is not required.", "The medical assistant can be provided with a computer, tablet, etc.", "to monitor the appointment for the medical kiosk, to cancel an appointment, to reschedule and appointment, to indicate if a patient missed an appointment or is late for an appointment, validate the ID of a patient, to view appointment information of the medical kiosk, to validate a patient's insurance, to monitor the need for the assistant to assist a patient via patient or medical provider request, to monitor the status of the visit by the patient (e.g., medical kiosk cleaned for patient, the patient has properly checked-in, appointment has started and vitals capture process has begun, vitals capture process completed, video consultation by medical provider with patient has begun, the video consultation with the medical provider has been completed, the medical provider is completing the patient report, the visit by the patient in the medical kiosk is completed, etc.", "), to assist in insurance and information processing and/or scheduling of a patient, to assist in the payment by the patient for medical services, to print out reports and/or email reports to patient that provide a summary or complete report to the patient regarding the visit to the medical kiosk, to activate the sanitation system of the medical kiosk (e.g., UV sanitation system, etc.", "), to keep a record of when the kiosk was cleaned/sanitized and/or what was cleaned/sanitized by the assistance (e.g., clean patient counter, clean patient touch screen desk, clean patient bench, clean entry doors, clean thermometer, clean dermascope, clean patient chair, clean interior walls, clean medical doors and handles, clean otoscope, clean pulse oximeter, clean floor, clean scale, clean video monitor, clean exterior of the medical kiosk, clean the medical assistant desk, clean the check-in screen on the exterior of the medical kiosk, clean walk-in mat, clean door tracks, clean UVC panel, clean inside ceiling, clean top of medical kiosk, clean UVC lights, clean medical device compartments, etc.", "), to enter information about the operation of the medical kiosk, to schedule a service call for the medical kiosk, to order parts or accessories for the medical kiosk, to verify the start and completion of an appointment, to process comment information by a patient, to create and/or send reports regarding the use of the medical kiosk, to escort the patient into and/or out of the medical kiosk, to begin the vitals capture process of the patient, provide information and/or instructions to a patient regarding the medical kiosk and/or regarding the proper use of the medical kiosk, to assist a potential patient in a tour of the medical kiosk, etc.", "In yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of an Attendant Application; however, this is not required.", "Generally, an Attendant Application is not used with a personal medical kiosk.", "The Attendant Application, when used, includes software and/or hardware that enables the attendant/medical assistant to 1) monitor, modify and/or cancel existing appointments for a medical kiosk, 2) monitor whether a patient requires assistance, 3) monitor and/or assist a patient during registration with the medical kiosk, 4) provide procedures and/or check lists for the medical assistant, and/or 5) provide information on the status of the medical kiosk.", "As can be appreciated, the Attendant Application can have other and/or additional functions.", "In one non-limiting arrangement, the initial Attendant's screen displays one or more appointment fields (e.g., time, patient name, medical provider name, status, action, etc.).", "For example, the time field, when used, can be designed to display the time of upcoming appointments on the medical kiosk; the patient name field, when used, can be designed to display the name of the patients for upcoming appointments on the medical kiosk; the provider name field, when used, can be designed to display the names of the providers for upcoming appointments on the medical kiosk; the status field, when used, can be designed to display the status of upcoming appointments on the medical kiosk (e.g., Ready—The medical kiosk has been sanitized and is ready for the next patient appointment, Checked-In—The patient has been checked-in and their appointment is pending, Pre Consult—The appointment has started and vitals capture process is in progress, In Visit—The vitals capture process has been completed and the video consultation with the medical provider is in progress, Post Consult—The video consultation with the medical provider has been completed and the medical provider is completing the visit, Completed—The appointment has been completed, etc.", "); and the actions field, when used, can be designed to display the availability of the Attendant functions.", "The actions field, when used, can be designed to allow for one or more actions (e.g., “X” icon, Clock icon, Printer icon, Emergency Clean-Up icon, etc.", "The “X” icon, when used, can be design to perform one or more functions such as to cancel an upcoming appointment; however, this is not required.", "The X icon can also allow entry and/or selection of a reason for cancellation (e.g., No Show—This action cancels the appointment, but maintains the patient record; Can't Make Appointment (Not Rescheduling)—This action cancels the appointment, but maintains the patient record; Patient Changed Mind—This action cancels the appointment, but maintains the patient record; Cancel Cancellation—This action cancels the cancellation; etc.).", "The Clock icon, when used, can be designed to reschedule an upcoming appointment; however, this is not required.", "When this icon is selected, entry and/or selection of one or more types of data can be allowed (e.g., input a date and time to reschedule an appointment, etc.", "); however, this is not required.", "The Printer icon, when used, can be designed to print a visit summary and/or some other type of information (e.g., prescription, coupons, follow-up visit information, survey and/or survey results, etc.", "); however, this is not required.", "This icon can be designed to only appear after an appointment has been completed and/or scheduled; however, this is not required.", "The Emergency Clean-Up icon, when used, can be designed to allow the medical attendant to associate an emergency clean-up with a patient appointment so as to be used for tracking purposes and/or some other purpose; however, this is not required.", "Upon selection of the Emergency Clean-Up icon, the medical attendant can be allowed to type a note regarding the emergency clean-up; however, this is not required.", "In still yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of an Attendant Application that allows the medical attendant/medical assistant to 1) view appointment information, 2) validate patient IDs, 3) validate patient insurance, 4) reschedule or cancel an appointment, and/or 5) perform the sanitization process for the medical kiosk; however, this is not required.", "In one non-limiting embodiment of the invention, once the patient is “Checked-In” via the patient registration process, the appointment status changes to “Pending.” At that time, the medical attendant can be required to validate the patient's ID; however, this is not required.", "For example, the medical attendant can 1) select the patient records (e.g., from the computer screen or monitor, etc.)", "and 2) select the “Validate Patient ID” button or similar type of button or selection; however, this is not required.", "If the patient is a new patient, the medical attendant can be prompted to insert and scan the patient's identification for the first time to be saved in the patient's electronic file.", "If the patient is a returning patient, the medical attendant can be prompted to “Update Patient ID”.", "If “Update Patient ID” is selected, the medical attendant can be prompted to “Start Scan” of updated patient ID.", "Once the patient's ID is validated and scanned, the medical attendant may be required to rescan the ID (if image quality is compromised) or save the image in the patient's file; however, this is not required.", "As can be appreciated, other or additional methods can be used to validate a patient's ID.", "In one non-limiting arrangement, the patient's identification is validated by use of a valid driver's license, US passport, military ID, and/or photo ID card issued by Federal, State, or Local government.", "As can be appreciated, other or additional types of IDs can be used.", "If the patient is under 18 or some other age designating a minor, the patient may be required to be accompanied by a parent or legal guardian; however, this is not required.", "If the patient is not accompanied by a parent or legal guardian, the patient may not be allowed to proceed with the visit.", "The medical assistant may be required to inform the under-18 or minor-age patient of certain rights when using the medical kiosk (e.g., It is not necessary for the parent or legal guardian to accompany the under-18 patient into the consultation; Anyone under 18 years of age needs to have parent or legal guardian to use the medical kiosk, etc.", "); however, this is not required.", "If the patient is under a certain age (e.g., 2 years old, etc.", "), the medical attendant may be required to inform the patient, parent and/or guardian that the patient to too young to use the medical kiosk, thus cannot proceed with the visit; however, this is not required.", "If a new patient indicates that they have insurance or a returning patient indicates their insurance information has changed, the patient may be prompted to see the medical attendant and/or be required to enter the insurance information; however, this is not required.", "The Attendant Application can prompt the medical attendant for entry of a copay amount and/or to scan the insurance card into the patient record; however, this is not required.", "As can be appreciated, the patient can enter the insurance information without a medical attendant and/or make a copayment without the medical attendant; however, this is not required.", "Once the patient's insurance is validated and entered and/or scanned, the medical attendant or patient may be required to rescan the ID (if image quality is compromised) and/or reenter the information if not entered properly or save the image and/or entered insurance information into the patient's file; however, this is not required.", "If the insurance information is not verified at a first try, the patient or medical attendant can attempt to reverify the insurance information; however, this is not required.", "Once the patient insurance is saved, the patient can be prompted to “Check in” for the next available appointment or select some appointment time and/or day in the future; however, this is not required.", "Once the patient is checked in for a visit to the kiosk, the appointment status will change to “Pre Consult” or some other statement on the screen of the Attendant Application; however, this is not required.", "At that time, the medical attendant may be required to recite a “Pre-Visit Summary” (e.g., “After your appointment is verified, you will step into the medical kiosk, your vitals are captured and you will meet with a medical provider over a video connection.", "The medical provider will provide the diagnoses and you may receive a prescription.", "The prescription can be sent to a pharmacy of your choice, etc.", "); however, this is not required.", "Once the patient is checked in and after any optional statement is made to the patient, the patient can enter the medical kiosk.", "The medical attendant may be required to escort the patient into the medical kiosk to initiate the vitals capture and/or consultation; however, this is not required.", "The medical attendant and/or patient can cause the Provider Application to prompt the medical provider to start the medical visit; however, this is not required.", "Once the medical provider completes the appointment via the Provider Application, the appointment status on the Attendant Application for a particular patient can be designed to change to “Completed”.", "Once the patient has completed the medical visit and exited the medical kiosk, the medical attendant may be required to perform a sanitization process; however, this is not required.", "Such sanitation process can include the medical attendant 1) selecting the patient record on the screen, and 2) selecting the Start Sanitization button or similar labeled button or selection.", "The medical attendant can enter the medical kiosk and perform the sanitization process.", "A screen that includes a check list or a paper check list can be used by the medical attendant to check off items that have been sanitized.", "For example, a screen inside the medical kiosk can include a check list and the medical assistant checks off each item as such item is sanitized by the medical attendant; however, this is not required.", "When all items are sanitized and optionally checked off, the medical attendant can select a button on the Attendant Application that the sanitation step is completed; however, this is not required.", "The medical attendant can optionally select to “Run UVC Light” or some other or additional automated sanitation system if such option is available; however, this is not required.", "Areas of the medical kiosk that can be cleaned after each visit and/or cleaned at period times based on some protocol are: patient counter, patient monitor screen, physician monitor screen, patient chair, seat at rear of station, kiosk wall panels, medical devices, medical device doors and handles, interior of kiosk, entry door of kiosk, internal wood surfaces in kiosk, attendant station, walk in door mat, floor of kiosk, door track of kiosk, external display monitor of kiosk, external surfaces of kiosk, UVC panel in kiosk, and/or UVC lights.", "The surfaces can be cleaned with wipes (e.g., Virox wipes [Towelettes with disinfecting chemicals that kill 99% of viruses and bacteria], glass cleaner, surface cleaners, floor cleaners, duster, dusting cloth, etc).", "Upon completion of the sanitization process, the medical kiosk status can return to “Ready” on the Attendant Application; however, this is not required.", "At that point, the medical attendant can start validation of the next patient's ID.", "In another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of a Patient Appointment or Registration Application to navigate patients through the vitals capture process, patient consultation, and/or survey; however, this is not required.", "The Patient Appointment or Registration Application can contain one or more navigational buttons on the patient screen that is located inside the medical kiosk (e.g., Back, Next, Cancel, Request Assistance, etc.", "); however, this is not required.", "The Back button, when used, allows the patient to return to the previous screen.", "The Next button, when used, allows the patient to proceed to the next screen.", "The Cancel button, when used, allows the patient to cancel a process and return to the beginning of the process.", "The patient can optionally receive a request to confirm the cancel procedure; however, this is not required.", "The Request Assistance button, when used, allows the patient to request assistance from the medical attendant.", "The selection of this button can be designed to also notify the patient that the medical attendant will be with them in a moment; however, this is not required.", "The selection of the Request Assistance button by the patient can result in the Attendant Application displaying on a screen a notice or generating a warning sound, etc.", "that the patient has requested assistance.", "For example, when the patient initiates the Request Assistance button, a pop-up box (e.g., orange box, red box, blue box, etc.)", "can appear on the medical attendant's screen that is labeled “kiosk,” colored orange, and indicates the patient requires assistance.", "As can be appreciated, the screen of the Provider Application, when used, can include an Alert Attendant button to notify the medical attendant that the patient requires assistance; however, this is not required.", "If the medical provider initiates the Alert Attendant button from the Provider Application, a pop-up box can be designed to appear on the medical attendant's screen that indicates the patient requires assistance.", "The pop-up box can be a colored box (e.g., red box, green box, orange box, etc.", "); however, this is not required.", "A sound can also or alternatively be generated by the Attendant Application, when used, to notify the medical attendant that the medical provider has selected the Alert Attendant button; however, this is not required.", "The Patient Appointment or Registration Application, when used, can be designed to allow the patient to 1) capture vitals, 2) perform the provider consultation, and/or 3) perform the survey.", "As can be appreciated, the Patient Appointment or Registration Application, when used, can be designed to allow the patient to perform other or additional functions.", "The Patient Appointment or Registration Application can be designed to appear on the Patient Screen and/or Provider Screen that are located in the interior of the medical kiosk; however, this is not required.", "The Provider Screen, when used, is the screen that is located above or adjacent to the Patient Screen; however, this is not required.", "The medical provider generally appears on the Provider Screen when the consultation starts; however, this is not required.", "The Patient Screen, when used, can provide information to the patient while located in the kiosk and/or allow the patient to enter information (e.g., patient receives vitals capture instructions on the Patient Screen and enters information as prompted, etc.).", "The Patient Appointment or Registration Application can be designed to capture vitals of the patient.", "The Patient Appointment or Registration Application can be designed to require the patient to initiate the vitals capture procedure and/or the medical attendant can initiated the vitals capture procedure for the patient.", "The Patient Appointment or Registration Application can be designed to navigate the patient and/or provide instructions to the patient for one or more of the vitals capture procedures; however, this is not required.", "During the vitals capture process, the patient can request that the medical assistant assist the patient in one or more of the procedures for capturing the vitals; however, this is not required.", "The Patient Appointment or Registration Application can be designed to require the patient to confirm that instructions for a particular vital capture procedure have been read and/or understood before proceeding with the next vital capture step; however, this is not required.", "The Patient Appointment or Registration Application can be designed to have the patient enter his/her height on the Provider Screen and/or Patient Screen; however, this is not required.", "The interior of the medical kiosk can include a height marker or height tape to enable a patient to determine his/her height; however, this is not required.", "The medical kiosk can include a camera or some other type of arrangement that can be used to automatically determine the height of the patient while the patient is positioned in the medical kiosk; however, this is not required.", "The Patient Appointment or Registration Application can be designed have the patient enter his/her weight on the Provider Screen and/or Patient Screen; however, this is not required.", "The interior of the medical kiosk can include a scale (e.g., built-in floor scale, etc.)", "that can be used by the patient to determine the patient's weight; however, this is not required.", "When a scale is provided in the medical kiosk, the weight can be automatically transferred to the Patient Appointment or Registration Application and/or can be manually entered by the patient.", "The Patient Appointment or Registration Application can be designed to have the patient obtain his/her temperature.", "The Patient Appointment or Registration Application can be designed to open a medical device cabinet that contains a thermometer; however, this is not required.", "The Patient Appointment or Registration Application can be designed to provide instructions and/or a video on how to use the thermometer (e.g., a) remove thermometer from open medical cabinet, b) place thermometer in ear, c) remove thermometer from ear after hearing a beep sound or other indicator that indicates procedure is completed, d) return thermometer to medical cabinet, etc.", "); however, this is not required.", "The Patient Appointment or Registration Application can be designed to have the patient obtain his/her blood pressure.", "The Patient Appointment or Registration Application can be designed to open a medical device cabinet that contains a blood pressure cuff and/or allows the blood pressure cuff to be plugged into the medical kiosk; however, this is not required.", "The Patient Appointment or Registration Application can be designed to provide instructions and/or a video on how to use the blood pressure cuff; however, this is not required.", "As can be appreciated, the medical attendant can place the blood pressure cuff on the patient entering the medical kiosk and/or after the patient has entered the medical kiosk; however, this is not required.", "If the blood pressure cuff requires that it be connected to the medical kiosk, the medical attendant or the patient can perform such connection.", "The patient or the medical attendant can start the blood pressure reading by selecting a button on the Patient Appointment or Registration Application; however, this is not required.", "The blood pressure cuff can be used to measure the blood pressure/heart rate of a patient.", "A real-time reading of the blood pressure/heart rate of a patient can be displayed on the Patient Screen and/or Provider Screen; however, this is not required.", "The patient or medical attendant can stop the process of capturing the blood pressure/heart rate of the patient; however, this is not required.", "After the completion of capturing all the vitals, the Patient Appointment or Registration Application can be designed to display on the Patient Screen and/or Provider Screen a summary of one or more of the captured vitals.", "The Patient Appointment or Registration Application can be designed to allow a patient to manually change one or more of the collected vitals; however, this is not required.", "Once the vitals capture process is completed, the patient can be prompted (e.g., “I'm Ready” button, etc.)", "to indicate that the patient is ready for the conference with the medical provider; however, this is not required.", "The Patient Appointment or Registration Application can be designed to notify the patient that the medical provider will be with them shortly; however, this is not required.", "Once the consultation has begun, the Patient Appointment or Registration Application can be designed to cause the medical provider to appear on the lower half of the Provider Screen and the patient's vitals appear on the upper half of the Provider Screen; however, this is not required.", "As can be appreciated, the full Provider Screen can only include the medical provider.", "The Patient Appointment or Registration Application can be designed to allow the patient to adjust the volume by use of volume buttons on the Patient Screen; however, this is not required.", "As can be appreciated, volume control can be located in other or additional locations in the medical kiosk.", "After the completion of the consultation, the Patient Appointment or Registration Application can be designed to ask the patient to complete a survey; however, this is not required.", "The Patient Appointment or Registration Application can be designed to allow the patient to skip the survey, when used, or to proceed with the survey; however, this is not required.", "If the patient selects the survey, when offered, one or more questions can be displayed on the Patient Screen and/or Provider Screen; however, this is not required.", "As can be appreciated, the medical attendant can provide the patient with a written survey and/or ask verbal survey questions; however, this is not required.", "At the completion of the survey, or if the patient chooses to skip the survey when such survey is offered, the Patient Appointment or Registration Application can be designed display a final screen thanking the patient for his/her visit and/or prompting them to request a visit summary from the medical attendant; however, this is not required.", "In still another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of a Provider Application that is designed to enable the medical provider to navigate through the appointment process during the patient appointment; however, this is not required.", "The Provider Application can be designed to allow the medical provider to a) display appointments, b) display patient information, c) view and/or modify visit information, d) perform the consultation, and/or e) utilize one or more medical devices in the medical kiosk.", "The Provider Application can be designed to cause screens to appear on the medical provider's computer, smart phone, smart TV, tablet, etc.", "at the medical provider's remote location; however, this is not required.", "The Provider Application can be designed to enable the medical provider to view appointments that have been completed by the medical provider, that are in progress by the medical provider and/or which are future appointments.", "In one non-limiting arrangement, the Provider Application can be designed to enable the medical provider to view appointments that have been completed by the medical provider or are in progress for a certain day (e.g., today, last Monday, etc.).", "In another non-limiting arrangement, the Provider Application can be designed to enable the medical provider to view appointments that have been made for a future time (e.g., two hours from the present, the next day, etc.).", "For example, the Provider Application can be designed to display on one portion of the screen (e.g., left side, right side, center, etc.)", "appointments for Today and Future.", "In one non-limiting arrangement, the Today tab can be designed to display one or more types of patient appointment information (e.g., Time—Time of appointment, Patient Name—Patient Name for appointment, Status—Status of appointment, Pending—Patient started the registration process, but has not yet been approved for payment, Checked-In—Patient has been checked-in, Pre Consult—Appointment has started and vitals are being collected, In Visit—Vitals have been collected and the video consultation is in-progress, Post Consult—Video consultation has been completed and medical provider completion is pending, Completed—Appointment has been completed, etc.).", "The Future tab can be designed to display one or more types of patient appointment information (e.g., Date—Date of appointment, Time—Time of appointment, Patient Name—Patient Name for appointment, etc.).", "The Provider Application can be designed to enable the medical provider to view a selected record on another portion of the screen; however, this is not required.", "The selected record can provide the medical provider one or more types of information (e.g., Patient Name, Patient Date of Birth, Patient Sex, Symptoms, Medical Conditions, Date of Last Visit, Diagnosis, Allergies, Medications, Prior Visit Record of Patient, Medical Records of Patient, etc.).", "The Provider Application can be designed to enable the medical provider to notify the medical attendant that the patient requires assistance; however, this is not required.", "The Provider Application can be designed to enable the medical provider to view the appointment and/or patient information prior to the vitals capture process.", "The Provider Application can be designed to limit access to a patient's information until a certain point (e.g., patient status is Checked-In, etc.", "); however, this is not required.", "The Provider Application can be designed to enable the medical provider to refuse an appointment that has been created for the medical provider; however, this is not required.", "Generally, such refusal should occur prior to the patient status of Checked-In to enable the system to locate another available medical provider; however, this is not required.", "The Provider Application can be designed to allow the medical provider to begin the conference with the patient once the patient is ready in the medical kiosk (e.g., after Check-In, after Capture of Vitals, etc.", "); however, this is not required.", "The Provider Application can be designed to cause a Start Visit button or similar button to appear on the medical provider's screen to allow the medical provider to begin the consultation with the patient; however, this is not required.", "Once the visit or consultation has been initiated, the Provider Application can be designed to update the appointment status to In Visit; however, this is not required.", "Once the visit or consultation has begun, the patient appears on a portion of the medical provider's screen (e.g., right side of screen, center of screen, left side of screen, etc.", "); however, this is not required.", "The medical provider may greet the patient in the medical kiosk with a greeting (e.g., “Welcome.", "Can you see me ok?", "Can you hear me ok?”, etc.", "); however, this is not required.", "The Provider Application can be designed to cause an End Consultation or similar button to appear on the medical provider's screen to terminate the consultation or visit with the patient and thereby terminate the video link between the medical provider and patient in the medical kiosk; however, this is not required.", "Once the consultation or visit with the patient is terminated, the Provider Application can be designed to cause the status of the patient to change to Post Consult; however, this is not required Post Consult means the video consultation has been completed and the medical provider is completing the visit summary.", "Once the medical provider has completed the visit summary and written any required prescriptions, the Provider Application can be designed to cause a Complete Appointment or similar button to appear on the medical provider's screen; however, this is not required.", "The selection of the Complete Appointment button or similar button after completion of the video consultation can result in the status of the patient to change to Completed; however, this is not required.", "Completed means the medical provider has completed input of all information and is ready to commence the next appointment.", "The Provider Application can be designed to allow the medical provider to view the patient records, including the vitals capture process that has occurred or is occurring in the medical kiosk.", "The Provider Application can be designed to cause one or more tabs to be displayed on the medical provider's screen once a patient record has been selected (e.g., Patient Information, Current Visit, Previous Visit, etc.).", "The Patient Information tab, when used, can list one or more types of information of the patient on the medical provider's screen (e.g., Personal Information, Medications, Allergies, Medical Conditions, etc.).", "One or more of these categories of information can be further expanded upon selection by the medical provider; however, this is not required.", "For example, selection of the Personal Information category can cause further information about the patient to be displayed (e.g., date of birth, sex, alcohol usage, smoker status, allergies, patient personality traits, marriage status, medication usage, drug history, psychological profile, recent medical/psychological issues, medical/drug compliance, profile, race, eye color, native language, citizenship, address, etc.", "); however, this is not required.", "The Current Visit tab, when used, can list one or more types of information about the patient on the medical provider's screen (e.g., Medications, Notes, Vitals, Devices, Visit Summary, Attendant Instructions, etc.).", "One or more of these categories of information can be further expanded upon selection by the medical provider; however, this is not required.", "For example, selection of the Medications category can cause further information about medications used by the patient (e.g., past medications used, past medications prescribed to patient, current medications used by the patient, medication compliance, etc.).", "The Previous Visit tab, when used, can list one or more types of information of the patient on the medical provider's screen (e.g., Symptoms, Notes, Vitals, Visit Summary, etc.).", "One or more of these categories of information can be further expanded upon selection by the medical provider; however, this is not required.", "For example, selection of the Vitals category can cause further information about the vitals that were captured during a previous visit to the current medical kiosk, some other medical kiosk, or at some other medical facility.", "In one non-limiting embodiment of the invention, the Provider Application is designed to cause at least three tabs to be displayed on the medical provider's screen once a patient record has been selected, namely Patient Information, Current Visit, and Previous Visit.", "The Patient Information tab contains sections for Personal Information, Medications, Allergies, and Medical Conditions; however, it can be appreciated that other or additional tab sections can be included.", "The Personal Information section contains one or more sub-sections, of which some or all the information was entered by the patient during the registration process.", "This information generally cannot be modified by the medical provider; however, this is not required.", "Non-limiting examples of information that can be displayed in the Personal Information section includes Date of Birth, Gender—Male or Female, Alcohol Use, Smoker status, Height, Age, Contact Information, Race, Eye Color, Hair Color, Native Language, Citizenship, Address, Psychological profile, etc.", "The Medications section allows the medical provider to see previously entered medications, search and select new medications, remove medications the patient is no longer taking, view medication compliance history of patient, etc.", "The Provider Application can be designed to allow a medical provider to add a medication by having the medical provider type in the medication and/or to start typing the medication name in the Search Medications drop down and allow a listing of matching medication names to appear for selection and then to select the proper medication.", "The Provider Application can be designed to allow a medical provider to delete a medication by having the medical provider select an X next to the medication.", "As can be appreciated, other or additional arrangements can be used to add and/or delete medications in a patient's record.", "The Allergies section allows the medical provider to view allergies as input by the patient.", "This function allows the medical provider to see previously entered allergies, search and select new allergies, and/or remove allergies.", "The Provider Application can be designed to allow a medical provider to add an allergy by having the medical provider type in the allergy and/or to start typing the allergy name in the Add Allergy dropdown and allow a listing of matching allergy names to appear for selection and then to select the proper allergy.", "The Provider Application can be designed to allow a medical provider to delete an allergy by having the medical provider select an “X” next to the allergy.", "As can be appreciated, other or additional arrangements can be used to add and/or delete allergies in a patient's record.", "The Medical Conditions section allows the medical provider to view patient medical conditions as input by the patient.", "This function allows the medical provider to see previously entered medical conditions, search and select new medical conditions, and/or remove medical conditions.", "The Provider Application can be designed to allow a medical provider to add a medical condition by having the medical provider type in the medical condition and/or to start typing the medical condition in the Add Medical Condition dropdown and allow a listing of matching medical condition names to appear for selection and then to select the proper medical condition.", "The Provider Application can be designed to allow a medical provider to delete a medical condition by having the medical provider select an X next to the medical condition.", "As can be appreciated, other or additional arrangements can be used to add and/or delete medical conditions in a patient's record.", "The Current Visit tab contains sections for Symptoms, Notes, Vitals, Devices, Visit Summary, and Attendant; however, it can be appreciated that other or additional tab sections can be included.", "The Symptoms section contains all of the patient's symptoms for the current visit as input by the patient.", "This function allows the medical provider to see entered symptoms, search and select new symptoms, and remove symptoms.", "The Provider Application can be designed to allow a medical provider to add a symptom by having the medical provider type in the symptom and/or to start typing the symptom in the Symptoms dropdown and allow a listing of matching symptom names to appear for selection and then to select the proper symptom.", "The Provider Application can be designed to allow a medical provider to delete a symptom by having the medical provider select an “X” next to the symptom.", "As can be appreciated, other or additional arrangements can be used to add and/or delete symptoms in a patient's record.", "The Notes section allows the medical provider to enter notes for the current visit.", "This information generally does not appear on the Appointment Summary and is intended for internal reference only; however, this is not required.", "The Provider Application can be designed to allow a medical provider to add or delete a note by typing a note in the note texted box or by deleting a note in the note text box.", "As can be appreciated, other or additional arrangements can be used to add and/or delete notes in a patient's record.", "The Vitals section contains the patient's vitals for the current visit.", "They are displayed dynamically on the provider's screen as the vitals capture process takes place; however, this is not required.", "This function allows the medical provider to see the vitals prior to starting and during the consultation; however, this is not required.", "This information is generally only displayed and cannot be updated; however, this is not required.", "Non-limiting vitals can include Height, Weight, Blood Pressure, Heart Rate, Oxygen Saturation, and Temperature.", "The Devices section contains icons of the medical devices that are located in the medical kiosk and/or can be used with the medical kiosk.", "On the interior of the medical kiosk, there can optionally be one or more medical containers/cabinets (e.g., 1-10, 2, 4, 6, etc.", "), wherein one or more can be locked upon patient entry into the medical kiosk.", "As can be appreciated, personal medical kiosks and other types of medical kiosks may or may not include and/or container/cabinets.", "The medical provider has the capability to unlock one or more of the medical cabinets in the medical kiosk as necessary.", "When the medical provider wants to unlock a medical device cabinet, the medical provider clicks on or selects the appropriate medical device icon on the medical provider's computer screen.", "This selection action can result in the activation of the medical device and/or the opening of the medical cabinet door that includes the selected medical device.", "As can be appreciated, the medical device cabinet can be opened by other or additional means.", "An audible sound can be generated (e.g., sound of dropping door, sound of a lock unlocking, etc.)", "when access to a medical cabinet is granted to a patient; however, this is not required.", "As can be appreciated, a visual indicator can also or alternatively be used to indicate that a patient can access a particular medical cabinet; however, this is not required.", "For personal medical kiosks, medical cabinets are not typically used.", "For personal medical kiosks, the medical provider generally informs the patient to use a particular medical device.", "Non-limiting medical devices that can be used during the use of the medical kiosk can include a thermometer, otoscope, stethoscope, dermascope, pulse oximeter, spirometer, blood pressure cuff, blood sugar analyzer, Blood Pressure Cuff, blood analyzer, etc.", "As can be appreciated, the medical attendant, when used, can provide one or more medical devices to a patient prior to and/or during the visit (e.g., blood pressure cuff, etc.).", "The Visit Summary section can be comprised of one or more sub-sections, some or all of which are input by the medical provider (e.g., Current Diagnoses, Treatment Plan, Follow-Up Care, Visit Documents, etc.", "); however, this is not required.", "The Current Diagnoses section, when used, allows for the provider to input diagnoses codes and descriptions for the current visit.", "The medical provider can update and/or enter a diagnoses by entering the name of the diagnoses and/or an ICD code in a drop down menu and/or search menu.", "Once the diagnoses name has been entered and/or searched and located, the medical provider can add the diagnoses to the patient's record.", "More than one diagnoses can be added to a patient's record during a single visit.", "Once the one or more diagnoses are entered, such diagnoses can be optionally displayed under the Current Diagnoses section.", "The Treatment Plan section, when used, allows for the medical provider to input a treatment plan for the current visit.", "Such treatment plan can be typed by the medical provider into a text box and this information can appear on the Appointment Summary for the patient to reference; however, this is not required.", "The Follow-Up Care section, when used, allows for the medical provider to input follow-up care for the current visit.", "Such follow-up care plan can be typed by the medical provider into a text box; however, this is not required.", "This information can appear on the Appointment Summary for the patient to reference; however, this is not required.", "The Visit Document section, when used, allows for the medical provider to input follow-up care for the current visit.", "The medical provider can include one or more visit documents and/or other types of documents (e.g., documents about the common cold, documents about rashes, documents about the flu, documents about lice, documents about acne, documents about abstinence/birth control, documents about drug usage/abuse, documents about alcohol usage/abuse, documents about child care, documents about personal hygiene, etc.)", "which can be provided to the patient along with the Appointment Summary; however, this is not required.", "The Attendant Instructions section, when used, allows for the medical provider to input attendant instructions for the current visit.", "Such information can be entered into a text box by the medical provider.", "This information may or may not be provided to the patient.", "The Previous Visit tab contains information about prior medical visits by the patient.", "When the Previous Visit tab is selected, a dropdown appears containing the dates of all previous visits.", "The medical provider can select a previous visit and then review information about the previous visit.", "Typically, the medical provider can only view one previous visit at a time.", "In one non-limiting arrangement, when the previous visit date is selected, one or more sections are displayed (e.g., Symptoms, Notes, Vitals, Visit summary, etc.).", "The Symptoms section, when used, allows for the medical provider to view all of the patient's symptoms from the previous visit as input by the patient and/or medical provider.", "The Notes section, when used, allows the medical provider to view all notes for the previous visit that were input by the medical provider in the prior visit.", "The Vitals section, when used, allows for the medical provider to view all of the patient's vitals that were captured during previous visits.", "The Visit Summary section, when used, allows for the medical provider to view all visit summary information input during a prior visit.", "This section can include one or more subsections (e.g., Treatment Plan, Follow-up Care, Visit Documents, etc.).", "In yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a method and a kiosk wherein before the video-conference between the medical provider and the patient begins, each patient starts with a Vitals Check to capture the following one or more of the information: Height, Weight, Temperature, Blood Pressure and/or Heart Rate.", "Thereafter, the patient and/or medical assistant can inform the medical provider that the visit is ready to begin; however, this is not required.", "In still yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a method and a kiosk wherein the kiosk includes one or more (e.g., six, etc.)", "advanced medical device cabinets which are locked upon patient entry; however, this is not required.", "Generally, the personal medical kiosk does not include the use of medical device cabinets.", "As can be appreciated, other types of kiosks may not include medical device cabinets.", "During the patient consultation, the medical provider has the capability to unlock and open these cabinets from the Provider Application on the Provider's computer; however, this is not required.", "The following medical devices can be contained within the cabinets: a thermometer, an otoscope, a stethoscope, a dermascope, a pulse oximeter, blood analyzer, and/or a blood pressure cuff Other or additional medical devices can be included in the medical kiosk (e.g., scale, height tape, eye chart, blood sugar analyzer, defibrillator, etc.).", "As can be appreciated, these medical devices can also be used with the personal medical kiosk.", "The stethoscope, when used, is used for detecting sounds produced in the body that are conveyed to the ears of the listener.", "The medical kiosk stethoscope sounds are transmitted from the stethoscope in the medical device (e.g., hardwire, USB, Bluetooth, Wi-Fi, etc.)", "to the medical provider's stethoscope.", "On the interior of the medical kiosk, the stethoscope can be contained in the first medical device cabinet on the left, when used; however, this is not required.", "The stethoscope can be activated by the medical provider via the Provider Application by the medical provider selecting the Stethoscope icon the provider's screen; however, the stethoscope can be activated by other or additional arrangements or always remain active.", "In one non-limiting arrangement, when the medical provider via the Provider Application selects the stethoscope icon on the provider's screen, the cabinet door in the medical kiosk for the stethoscope opens (e.g., drops down, etc.)", "to enable the patient in the medical kiosk to access the stethoscope; however, this is not required.", "The medical provider can provide instructions to the patient on how to use the stethoscope (e.g., Once the patient has removed the device, request for patient to turn on the stethoscope on the stethoscope device.", "The “On” button is the lower most button on the device; it looks like a smiley face with one eye.", "Tell the patient to attempt to hold the device on the sides, while using it, so other buttons are not depressed, etc.)", "and/or instructions for use of the stethoscope can be provided on the Patient Screen and/or Provider Screen in the medical kiosk; however, this is not required.", "When the stethoscope is selected, a video image can be designed to appear on the Provider Application (e.g., medical provider's screen) and/or the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk.", "If a video image option is available for display on the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk, the medical provider via the Provider Application can turn off such video image on the Provider Screen and/or Patient Screen; however, this is not required.", "The medical provider via the Provider Application can capture images and/or data generated by the stethoscope and/or video camera in the medial kiosk for placement in the patient's file; however, this is not required.", "The medical provider via the Provider Application can optionally annotate an image once captured (e.g., use the paint brush and font icons to modify image, etc.)", "and/or show the captured image to the patient; however, this is not required.", "The medical provider via the Provider Application can increase and/or decrease the volume received from the stethoscope; however, this is not required.", "As can be appreciated, the patient can increase and/or decrease the volume from the stethoscope; however, this is not required.", "The medical provider and/or patient can request assistance by the medical assistant, when available, related to the stethoscope if so required.", "The otoscope, when used, is a device used for examining the internal ear.", "The image generated by the otoscope in the medical kiosk can be displayed on the Patient's Screen and/or Provider's Screen in the medical kiosk and/or on the screen being used by the medical provider; however, this is not required.", "The transmission of the signal can be by various means (e.g., hardwire, USB, Bluetooth, Wi-Fi, etc.).", "On the interior of the medical kiosk, the otoscope can be contained in the second medical device cabinet on the left in the medical kiosk, when a cabinet is used; however, this is not required.", "The otoscope can be activated by the medical provider via the Provider Application by the medical provider selecting the otoscope icon on the provider's screen; however, the otoscope can be activated by other or additional arrangements or always be on.", "In one non-limiting arrangement, when the medical provider via the Provider Application selects the otoscope icon on the provider's screen, the cabinet door in the medical kiosk for the otoscope opens (e.g., drops down, etc.)", "to enable the patient in the medical kiosk to access the otoscope; however, this is not required.", "The medical provider can provide instructions to the patient on how to use the otoscope (e.g., Once the patient has pulled out the device, request for patient to place the otoscope in the appropriate ear lobe, then adjust the focus dial.", "The focus dial is on the top of the otoscope.", "The patient can push it to the top and then dial it down to determine to focus; To direct the patient to maneuver the otoscope for best image capture, use the interior of the medical kiosk as reference points.", "Once the device is in the patient's ear canal, instruct them (or the individual assisting them) to move the device towards the front, back, bottom, and top of the medical kiosk, etc.)", "and/or instructions for use of the otoscope can be provided on the Patient Screen and/or Provider Screen in the medical kiosk; however, this is not required.", "When the otoscope is selected, a video image can be designed to appear on the Provider Application (e.g., medical provider's screen) and/or the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk.", "If a video image option is available for display on the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk, the medical provider via the Provider Application can turn off such video image on the Provider Screen and/or Patient Screen; however, this is not required.", "The medical provider via the Provider Application can capture images and/or data generated by the otoscope and/or video camera in the medial kiosk for placement in the patient's file; however, this is not required.", "The medical provider via the Provider Application can optionally annotate an image once captured (e.g., use the paint brush and font icons to modify image, etc.)", "and/or show the captured image to the patient; however, this is not required.", "The medical provider via the Provider Application can adjust the focus of the otoscope; however, this is not required.", "As can be appreciated, the patient can adjust the focus of the otoscope; however, this is not required.", "The medical provider and/or patient can request assistance, when available, by the medical assistant related to the otoscope if so required.", "The thermometer, when used, is used for detecting human internal heat.", "The temperature that is transmitted by the thermometer can be displayed on the Patient's Screen and/or Provider's Screen in the medical kiosk and/or on the screen being used by the medical provider; however, this is not required.", "The transmission of the signal can be by various means (e.g., hardwire, USB, Bluetooth, Wi-Fi, etc.).", "On the interior of the medical kiosk, the thermometer can be contained in the third medical device cabinet on the left in the medical kiosk, when a cabinet is used; however, this is not required.", "The patient's temperature can be collected during the vitals capture process which is prior to the consultation with the medical provider; however, this is not required.", "If the medical provider wants the temperature to be retaken or if the temperature of the patient has not already been taken, the thermometer can be activated or reactivated by the medical provider via the Provider Application by the medical provider selecting the thermometer icon on the provider's screen; however, the thermometer can be activated by other or additional arrangements or always be on.", "In one non-limiting arrangement, when the medical provider via the Provider Application selects the thermometer icon on the provider's screen, the cabinet door in the medical kiosk for the thermometer opens (e.g., drops down, etc.", "), if not already open, to enable the patient in the medical kiosk to access the thermometer; however, this is not required.", "The medical provider can provide instructions to the patient on how to use the thermometer (e.g., Once the patient has pulled out the device, request for patient to turn on the thermometer.", "The “On” button is on the inside handle of the device; Request for the patient to insert the thermometer into their ear and press the button on top of the handle to start the reading.", "Once the patient's temperature is collected, a beep will sound; Once the beep is sounded to indicate the temperature reading has completed, the patient can hit the “Temperature Recorded” button on the patient screen, etc.)", "and/or instructions for use of the thermometer can be provided on the Patient Screen and/or Provider Screen in the medical kiosk; however, this is not required.", "When the thermometer is selected, a video image can be designed to appear on the Provider Application (e.g., medical provider's screen) and/or the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk.", "If a video image option is available for display on the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk, the medical provider via the Provider Application can turn off such video image on the Provider Screen and/or Patient Screen; however, this is not required.", "The medical provider via the Provider Application can capture images and/or data generated by the thermometer and/or video camera in the medial kiosk for placement in the patient's file; however, this is not required.", "The medical provider via the Provider Application can optionally annotate an image once captured (e.g., use the paint brush and font icons to modify image, etc.)", "and/or show the captured image to the patient; however, this is not required.", "The medical provider and/or patient can request assistance by the medical assistant, when available, if so required.", "In one non-limiting arrangement, the temperature must register between 95.0 degrees and 105.9 degrees; however, this is not required.", "Temperatures under or above 95.0 degrees or some other temperature and 105.9 degrees or some other temperature can be designed to create an error and request the patient to manually enter their temperature, request the patient to try again to take a proper temperature, and/or request the medical assistant to assist the patient related to the thermometer; however, this is not required.", "The dermascope, when used, is used to visualize body surface, skin, hair, scalp, eyes, and/or throat with magnification and/or illumination.", "The image generated by the dermascope in the medical kiosk can be displayed on the Patient's Screen and/or Provider's Screen in the medical kiosk and/or on the screen being used by the medical provider; however, this is not required.", "The transmission of the signal can be by various means (e.g., hardwire, USB, Bluetooth, Wi-Fi, etc.).", "On the interior of the medical kiosk, the dermascope can be contained in the first medical device cabinet on the right in the medical kiosk, when a cabinet is used; however, this is not required.", "The dermascope can be activated by the medical provider via the Provider Application by the medical provider selecting the dermascope icon on the provider's screen; however, the dermascope can be activated by other or additional arrangements or always be on.", "In one non-limiting arrangement, when the medical provider via the Provider Application selects the dermascope icon on the provider's screen, the cabinet door in the medical kiosk for the dermascope opens (e.g., drops down, etc.)", "to enable the patient in the medical kiosk to access the dermascope; however, this is not required.", "The medical provider can provide instructions to the patient on how to use the dermascope (e.g., Once the patient has pulled out the device, request for patient to place the dermascope device at the appropriate place, then request for the patient to adjust the focus dial.", "The focus dial is on the top handle of the dermascope.", "The patient can push it to the top and then dial it down to determine appropriate focus, etc.)", "and/or instructions for use of the dermascope can be provided on the Patient Screen and/or Provider Screen in the medical kiosk; however, this is not required.", "When the dermascope is selected, a video image can be designed to appear on the Provider Application (e.g., medical provider's screen) and/or the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk.", "If a video image option is available for display on the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk, the medical provider via the Provider Application can turn off such video image on the Provider Screen and/or Patient Screen; however, this is not required.", "The medical provider via the Provider Application can capture images and/or data generated by the dermascope and/or video camera in the medial kiosk for placement in the patient's file; however, this is not required.", "The medical provider via the Provider Application can optionally annotate an image once captured (e.g., use the paint brush and font icons to modify image, etc.)", "and/or show the captured image to the patient; however, this is not required.", "The medical provider via the Provider Application can adjust the focus of the dermascope; however, this is not required.", "As can be appreciated, the patient can adjust the focus of the dermascope; however, this is not required.", "The medical provider and/or patient can request assistance by the medical assistant, when available, related to the dermascope if so required.", "The pulse oximeter, when used, is used for measuring the amount of saturated hemoglobin the tissue capillaries by transmitting a beam of light through the tissue to a receiver.", "The image generated by the pulse oximeter in the medical kiosk can be displayed on the Patient's Screen and/or Provider's Screen in the medical kiosk and/or on the screen being used by the medical provider; however, this is not required.", "The transmission of the signal can be by various means (e.g., hardwire, USB, Bluetooth, Wi-Fi, etc.).", "On the interior of the medical kiosk, the pulse oximeter can be contained in the second medical device cabinet on the right in the medical kiosk, when a medical cabinet is used; however, this is not required.", "The pulse oximeter can be activated by the medical provider via the Provider Application by the medical provider selecting the pulse oximeter icon on the provider's screen; however, the pulse oximeter can be activated by other or additional arrangements or always be on.", "In one non-limiting arrangement, when the medical provider via the Provider Application selects the pulse oximeter icon on the provider's screen, the cabinet door in the medical kiosk for the pulse oximeter opens (e.g., drops down, etc.)", "to enable the patient in the medical kiosk to access the pulse oximeter; however, this is not required.", "The medical provider can provide instructions to the patient on how to use the pulse oximeter (e.g., Provider: Once the patient has pulled out the device, request for patient to place the device on their index finger as illustrated by the diagram on the top on the device.", "The picture is a fingernail print which should align to the patient's fingernail, etc.)", "and/or instructions for use of the pulse oximeter can be provided on the Patient Screen and/or Provider Screen in the medical kiosk; however, this is not required.", "When the pulse oximeter is selected, a video image can be designed to appear on the Provider Application (e.g., medical provider's screen) and/or the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk.", "If a video image option is available for display on the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk, the medical provider via the Provider Application can turn off such video image on the Provider Screen and/or Patient Screen; however, this is not required.", "The medical provider via the Provider Application can capture images and/or data generated by the pulse oximeter and/or video camera in the medial kiosk for placement in the patient's file; however, this is not required.", "The medical provider via the Provider Application can optionally annotate an image once captured (e.g., use the paint brush and font icons to modify image, etc.)", "and/or show the captured image to the patient; however, this is not required.", "The medical provider via the Provider Application can adjust the focus of the pulse oximeter; however, this is not required.", "As can be appreciated, the patient can adjust the focus of the pulse oximeter; however, this is not required.", "The medical provider and/or patient can request assistance by the medical assistant, when available, related to the pulse oximeter if so required.", "The scale, when used, is used to obtain the weight of the patient.", "The weight that is transmitted by the scale can be displayed on the Patient's Screen and/or Provider's Screen in the medical kiosk and/or on the screen being used by the medical provider; however, this is not required.", "The transmission of the signal from the scale can be by various means (e.g., hardwire, USB, Bluetooth, Wi-Fi, etc.).", "As can be appreciated, the weight can be manually entered.", "On the interior of the medical kiosk, when the kiosk has an interior enclosure, the scale can be located on the floor of the medical kiosk; however, this is not required.", "The patient's weight can be collected during the vitals capture process which is prior to the consultation with the medical provider; however, this is not required.", "If the medical provider wants the patient's weight to be retaken or if the patient's weight has not already been taken, the scale can be activated or reactivated by the medical provider via the Provider Application by the medical provider selecting the thermometer icon on the provider's screen; however, the scale can be activated by other or additional arrangements.", "In one non-limiting arrangement, when the medical provider via the Provider Application selects the scale icon on the provider's screen, information from the scale or information that is manually entered is conveyed to the medical provider; however, this is not required.", "The medical provider can provide instructions to the patient on how to use the scale (e.g., Request for the patient to step on the scale and wait for the recording to be completed, etc.)", "and/or instructions for use of the scale can be provided on the Patient Screen and/or Provider Screen in the medical kiosk; however, this is not required.", "When the scale is selected, a video image can be designed to appear on the Provider Application (e.g., medical provider's screen) and/or the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk.", "If a video image option is available for display on the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk, the medical provider via the Provider Application can turn off such video image on the Provider Screen and/or Patient Screen; however, this is not required.", "The medical provider via the Provider Application can capture images and/or data generated by the scale and/or video camera in the medial kiosk for placement in the patient's file; however, this is not required.", "The medical provider via the Provider Application can optionally annotate an image once captured (e.g., use the paint brush and font icons to modify image, etc.)", "and/or show the captured image to the patient; however, this is not required.", "The medical provider and/or patient can request assistance by the medical assistant, when available if so required.", "As can be appreciated, a patient can weigh himself/herself on the scale and then manually enter the data for use by the medical provider; however, this is not required.", "In one non-limiting arrangement, the weight must register no greater than 501 pound or some other upper limit; however, this is not required.", "Weights that are above the upper weight limit can be designed to create an error and request the patient to manually enter their weight, request the patient to try again to take a proper weight, and/or request the medical assistant to assist the patient related to the scale; however, this is not required.", "The scale can be positioned in any location in the medical kiosk (e.g., floor, bench, chair, etc.).", "A lower weight limit can also be used to create an error which requires the user to try again and obtain a proper weight.", "In one non-limiting embodiment, the scale can be integrated into the medical kiosk in such a way that it at least partially incorporated in on the floor of the medical kiosk.", "In one non-limiting design, the scale is positioned flush with the floor so that it poses no safety challenges for the user/patient in the medical kiosk; however, this is not required.", "As can be appreciated, the size, shape, and type of scale are non-limiting.", "The scale in the floor of the kiosk can also optionally be used as designated standing location of a patient so that a height of the patient can be obtained by use of one or more cameras and/or other electronic devices in the medical kiosk; however, this is not required.", "The blood pressure cuff, when used, is used to determine the arterial pressure of the systemic circulation.", "The blood pressure cuff can also be used to obtain the pulse rate of the patient.", "The information that is transmitted by the blood pressure cuff can be displayed on the Patient's Screen and/or Provider's Screen in the medical kiosk and/or on the screen being used by the medical provider; however, this is not required.", "The transmission of the signal from the scale can be by various means (e.g., hardwire, USB, Bluetooth, Wi-Fi, etc.).", "On the interior of the medical kiosk, the blood pressure cuff can be contained in the third medical device cabinet on the right in the medical kiosk, when a medical cabinet is used; however, this is not required.", "Alternatively, the blood pressure cuff can be kept with the medical attendant, when available, and the medical attendant then assists the patient in placing the blood pressure cuff on the patient prior to the patient entering the medical kiosk or while the patient is located in the medical kiosk; however, this is not required.", "The patient's blood pressure can be collected during the vitals capture process which is prior to the consultation with the medical provider; however, this is not required.", "If the medical provider wants the patient's blood pressure to be retaken or if the patient's blood pressure has not already been taken, the blood pressure cuff can be activated or reactivated by the medical provider via the Provider Application by the medical provider selecting the blood pressure cuff icon on the provider's screen; however, the blood pressure cuff can be activated by other or additional arrangements.", "In one non-limiting arrangement, when the medical provider via the Provider Application selects the blood pressure cuff icon on the provider's screen, the cabinet door in the medical kiosk for the blood pressure cuff opens (e.g., drops down, etc.)", "to enable the patient in the medical kiosk to access the blood pressure cuff if the blood process cuff is located in a medical device cabinet; however, this is not required.", "Alternatively, the selection of the blood pressure cuff results in information from the blood pressure cuff being sent to the medical provider.", "As can be appreciated, if the blood pressure cuff is not located in a medical cabinet, that patient can obtain the blood pressure cuff from the location in which blood pressure cuff currently exists (e.g., in the medical kiosk, next to the medical kiosk, etc.)", "or the medical assistant, when available, can provide the blood pressure cuff to the patient if the medical attendant is retaining the blood pressure cuff.", "In another non-limiting arrangement, the medical kiosk can optionally include an ambidextrous blood pressure cuff.", "The cuff arm can optionally be mounted to the desk top to enable the blood pressure cuff to be moved from side to side of the desk top; however, this is not required.", "Such movement of the blood pressure cuff enables the blood pressure cuff to be positioned so that the left arm or right arm of a user can be inserted into the blood pressure cuff when the user is facing the desk top.", "As can be appreciated, when a blood pressure cuff is included in the medical kiosk, it can be mounted and/or positioned in the medical kiosk in a variety of ways.", "Information to and from the blood pressure cuff, when used, can be transmitted by wire and/or wirelessly to one or more computers, processors, storage devices, etc.", "in the medical kiosk and/or to a location remote from the medical kiosk.", "The ambidextrous blood pressure cuff, when used, may be made of high-strength plastic or any other sufficiently rigid and/or strong material (e.g., metal, composite material, etc.).", "The cuff arm can be designed to be manually moved by the patient/user, be remotely moved by the medical provider and/or medical kiosk assistant, and/or be electronically moved by the patient/user.", "The blood pressure cuff can be designed to be activated/deactivated by the patient/user and/or remotely by the medical provider and/or medical kiosk assistant, or always be on.", "The medical provider can provide instructions to the patient on how to use the blood pressure cuff (e.g., The blood pressure cuff is most effective when the patient fully places their bicep in the cuff, with the palm of their hand facing the ceiling, etc.)", "and/or instructions for use of the blood pressure cuff can be provided on the Patient Screen and/or Provider Screen in the medical kiosk; however, this is not required.", "When the blood pressure cuff is selected, a video image can be designed to appear on the Provider Application (e.g., medical provider's screen) and/or the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk.", "If a video image option is available for display on the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk, the medical provider via the Provider Application can turn off such video image on the Provider Screen and/or Patient Screen; however, this is not required.", "The medical provider via the Provider Application can capture images and/or data generated by the blood pressure cuff and/or video camera in the medial kiosk for placement in the patient's file; however, this is not required.", "The medical provider via the Provider Application can optionally annotate an image once captured (e.g., use the paint brush and font icons to modify image, etc.)", "and/or show the captured image to the patient; however, this is not required.", "The medical provider via the Provider Application can start and/or stop the blood pressure operation; however, this is not required.", "As can be appreciated, the patient can start and/or stop the blood pressure operation; however, this is not required.", "The medical provider and/or patient can request assistance by the medical assistant related to the blood pressure cuff if so required.", "In another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a scheduling application that 1) enables a medical provider to input the day and time the medical provider is available to conduct a visit with a patient in a medical kiosk, 2) obtains or collects information on appointments that have been made by one or more patients at one or more medical kiosks, and 3) assigns a medical provider to a particular appointment that has been made at a particular medical kiosk; however, this is not required.", "The scheduling application can be designed to enable a patient to select a particular medical provider, gender of a medical provider, specialty of a medical provider, a medical provider that can speak a certain language, etc.", "; however, this is not required.", "The scheduling application can be designed to allow a medical provider to refuse an appointment with a particular patient; however, this is not required.", "If the medical provider refuses an appointment, the scheduling application can be designed to attempt to schedule a different appointment for the newly available time slot of the medical provider, or can block off such time and not reschedule a new appointment for such time period; however, this is not required.", "The scheduling application can be designed to select a medical provider for a particular appointment based on a set algorithm (e.g., available medical provider that has the largest time since last appointment, available medical provider that accepts patient's insurance, available medical provider that is located closest to home residence of patient, etc.)", "and/or by a random process.", "The scheduling application can be designed to attempt to select a new medical provider for a particular appointment if the originally selected medical provider is unable and/or unwilling to conduct a visit with a patient in the medical kiosk; however, this is not required.", "In still another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medication adherence application; however, this is not required.", "The medication adherence application can be designed to reduce medication errors.", "The medication adherence application can include a reminder for patients to take their medications and then optionally the system can automatically log when the patient takes their medication; however, this is not required.", "The medication adherence application can also include the ability to track a patient's compliance to taking their medication on time and/or provide automatic progress reports; however, this is not required.", "The medication adherence application can also include the ability to remind the patient to timely take medications (e.g., text reminder, email reminder, phone call reminder, twitter reminder, video conference reminder, etc.", "); however, this is not required.", "The medication adherence application can also include the ability to refer the patient to a pharmacist to answer any questions and/or for additional consultation; however, this is not required.", "Each user/patient utilizing the medical kiosk can be automatically enrolled in the e-script network, which network sends their prescriptions to the pharmacy of their choice; however, this is not required.", "The medication adherence application can be used to assist in improving patient outcomes and/or satisfaction.", "The medication adherence application of the present invention can be designed to be used on a screen in the medical kiosk, and/or on a computer screen and/or mobile device; however, this is not required.", "The medication adherence application of the present invention can be designed to generate a screen that includes one or more main buttons (e.g., 1) Speak to a ______ (e.g., Walgreens, CVS, Wal-Mart, etc.)", "Pharmacist now, 2) Change my medications alerts, 3) Learn about controlling my ______ (e.g., cholesterol, high blood pressure, diabetes, etc.", "), 4) Check orders status, 5) Refill Prescriptions, etc., 6) Transfer prescriptions to ______ (e.g., Walgreens, CVS, Wal-Mart, etc.", "), 7) Recommended dosage, 8) Period for taking medications, 9) Frequency for taking medications, 10) Information about medications, 11) Generic brands available for medications, 12) Request appointment to speak with a medical provider, 13) Entry of compliance information regarding medication usage by patient, etc.", "); however, this is not required.", "The screen can include additional buttons (e.g., help button, Finish button, etc.", "); however, this is not required.", "The screen can include advertising information; however, this is not required.", "The selection of one or more of the button can result in additional screens appearing based on the selected button; however, this is not required.", "If a user/patient needs further guidance from the pharmacist regarding the prescribed medication, the user/patient can select the first category button to request such information; however, this is not required.", "The patient/user can be provided a number to call and/or allow the user to send an email, make a phone call, etc.", "regarding the question.", "The user/patient can be provided the option to set a new appointment to meet with a medical provider regarding the medication; however, this is not required.", "The user/patient can be provided the option to change the medication alerts; however, this is not required.", "Such change can be requested by telephone, email, text, etc.", "The frequency and/or type of alert and/or the manner in which the alert is sent to the user/patient (e.g., email, twitter, phone message, text, etc.)", "may also be modified by the user/patient; however, this is not required.", "The user/patient may be provided the option to obtain information about certain medical conditions (e.g., cholesterol, blood pressure, migraines, back pain, arthritis, allergies, flu, etc.", "); however, this is not required.", "The user/patient may be provided the option to obtain the order status, shipment status, etc.", "for a particular medication; however, this is not required.", "If allowable by current medication guidelines and/or medical plans, the patient may request to fill their prescriptions directly through the application; however, this is not required.", "The user/patient may be provided the option to change their preferred prescription location; however, this is not required.", "The user/patient may be provided the option to enter information as to whether the prescribed medications are being timely taken and in the proper amounts; however, this is not required.", "Periodic reports regarding medication compliance can be generated and provided to the user/patient via phone, email, text, twitter, etc.", "; however, this is not required.", "The medication adherence application of the present invention can be used to allow the patient to more easily obtain and understand the correct usage of their prescriptions.", "In summary, the medication adherence software application allows a user/patient to 1) speak to a pharmacist, 2) change the patient's medications alerts, 3) learn about certain types of medical conditions, 4) check medication orders status, 5) check medication delivery status, 6) refill a prescriptions, 7) transfer prescriptions to a another location, 8) obtain information about recommended medication dosages, 9) obtain information about recommended times to take medications, 10) obtain information about recommended frequency for taking medications, 11) obtain information about medications, 12) obtain information about generic brands available for medications, 13) request an appointment to speak with a medical provider, 14) enter information regarding compliance information regarding medication usage by patient, and/or 15) receive compliance reports for patients regarding medication usage.", "In yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include an expandable mounting system for medical devices; however, this is not required.", "Such an arrangement is generally for kiosks other than personal medical kiosks; however, this is not required.", "In one non-limiting embodiment of the invention, the medical kiosk includes one or more equipment chambers that can be positioned on or near the front interior wall of the medical kiosk; however, it can be appreciated that one or more equipment chambers can be positioned in other or additional regions of the medical kiosk.", "The equipment chambers are used to store one or more medical devices (e.g., stethoscope, otoscope, thermometer, dermascope, spirometer, pulse oximeter, heating pad, magnifying glass, tongue depressor, tweezers, blood glucometer etc.).", "The one or more equipment chambers can also or alternatively be used to include other types of materials (e.g., tissue, Band-Aid, gauze, cotton ball, disinfecting wipe, cortisone cream, antibiotic cream/ointment, alcohol wipe, cotton swab, fabric wrap, etc.).", "The one or more equipment chambers generally include a door to limit access to the one or more equipment chambers; however, this is not required.", "The door, when used on one or more of the equipment chambers, can be manually openable/closeable, and/or the doors can be controllably opened/closed remotely by the medical provider and/or medical attendant.", "Generally, one or more of the doors are controllably opened and/or unlocked by the medical provider during the examination of the user in the medical kiosk; however, this is not required.", "After the user/patient has left the medical kiosk, the medical attendant, when available or used, can enter the medical kiosk, clean the medical equipment that was handled or used by the prior user/patient, and/or dispose of and/or replace items that were used and/or handled by the prior user/patient; however, this is not required.", "Thereafter, the medical attendant can restock, replace, and/or reposition the medical equipment and/or non-medical equipment in the equipment chambers and close the equipment chamber doors prior to the next user/patient entering the medical kiosk; however, this is not required.", "One or more types of medical equipment can be designed to transmit information by wire or wirelessly to electronic components in the medical kiosk and/or to the remotely located medical provider; however, this is not required.", "In one non-limiting arrangement, the medical kiosk can include six (6) equipment chambers (e.g., medical device cabinets, etc.)", "having doors, three on each side of the desk top of the medical kiosk.", "As can be appreciated, a larger or smaller number of equipment chambers can be used and/or the one or more equipment chambers can be positioned in other or additional locations in the medical kiosk.", "As also can be appreciated, some or all of the equipment chambers can be absent doors.", "The door on one or more of the equipment chambers can be designed to be unlocked and/or opened remotely by the medical provider and/or medical attendant; however, this is not required.", "The doors can be designed to automatically lock closed when the doors are closed by the medical attendant and/or medical provider after the user/patient has left the medical kiosk; however, this is not required.", "Each of the equipment chambers can be designed to include a different piece of medical equipment (e.g., stethoscope, otoscope, thermometer, dermascope, spirometer, and pulse oximeter); however, other or additional equipment and/or materials can be included in one or more of the equipment chambers (e.g., wipes, blood sugar analyzer, tissue, band aide, gauze, urine sample container, medication, defibrillator, blood pressure cuff, an audiometer to test hearing, a 3-lead EKG, a glucometer to measure blood glucose levels, etc.).", "Alternatively, the equipment chambers can be used to store one or more integrated medical devices that can include, but are not limited to, the following integrated devices: a stethoscope to evaluate heart, lung and/or bowel sounds; a thermometer to record temperature; an otoscope to examine the ear drum, external ear canal, nasal passages, mouth and/or throat; pulse oximeter to measure blood oxygen saturation and/or heart rate; a spirometer and transducer to measure the volume of air inspired and/or expired by the lungs; an audiometer to test hearing; a 3-lead EKG to provide a snapshot of the heart rhythm and/or data regarding stress and/or injury to the heart muscle; and/or a glucometer to measure blood glucose levels.", "As can be appreciated, other or additional medical devices can be included in the medical kiosk which are inside or outside of the expandable mounting system such as, but not limited to, a scale, lab-on-a-chip finger stick technology, blood analyzer (e.g., blood sugar analyzer, blood toxicity analyzer, blood oxygen content analyzer, etc.", "), height tape and others; however, this is not required.", "As can also be appreciated, a larger or smaller number of medical equipment can be used with and/or included in the medical kiosk and/or different types of medical equipment can be used with and/or included in the medical kiosk.", "The one or more equipment chambers can also or alternatively be used to include other types of material (e.g., tissue, gauze, disinfecting wipe, cotton ball, tongue depressor, tweezers, cortisone cream, urine sample container, etc.", "); however, this is not required.", "The one or more equipment chambers generally include a door to limit access to the one or more equipment chambers; however, this is not required.", "The door, when used, can be manually openable/closeable, and/or the doors can be controllably open/closed remotely by the medical provider or medical attendant; however, this is not required.", "The expandable mounting system for medical devices can be made of high-strength plastic or any other sufficiently rigid and strong material such as metal, wood, and the like.", "The configuration and/or size of each the equipment chambers can be the same or different.", "The one or more doors on the expandable mounting system can be manually opened and/or closed and/or remotely opened and/or closed by a medical provider and/or medical attendant.", "The one or more medical devices in the one or more chambers or bays can be activated/deactivated remotely by software and/or manually activated/deactivated.", "The one or more medical devices in the one or more chambers or bays can be connected to a connector in the chambers or bays so as to supply power to the medical device and/or to electronically transmit information between the medical device and a computer, network, storage device, etc.", "The expandable mounting system can include one or more visual indicators (e.g., light, etc.)", "to indicate to a user/patient which chamber is to be used and/or is active.", "A medical attendant and/or medical provider can be used to assist the patient in the operation of one or more medical devices; however, this is not required.", "In still yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include digital signage on the exterior of the medical kiosk; however, this is not required.", "Generally, the personal medical kiosk does not include digital signage; however, this is not required.", "The medical kiosk can include advertisements that are displayed on the display; however, this is not required.", "The digital signage, when used, can be displayed through one or more monitors or display screens on the exterior and/or interior of the medical kiosk to able a user/patient/potential user to see one or more of the monitors or display screens.", "One non-limiting aspect of this invention is that the one or more monitors or display screens can be used to display advertisements that may be arranged by the originating site; however, this is not required.", "Another non-limiting aspect of this invention is that one or more of the monitors or display screens can be used to display the current wait time for the medical kiosk and/or the list of scheduled appointments; however, this is not required.", "The digital signage application can allow various companies to advertise via the medical kiosk, including the business where it is located; however, this is not required.", "The digital signage application can be tailored to display information for specific patients based upon their conditions; however, this is not required.", "The digital signage application can include the ability to display a scrolling message at the bottom of the screen, based upon the business's preference; however, this is not required.", "The one or more display screens and/or monitors can be used to provide various types of information (e.g., registration information, information input by the user, advertising information, information about the medical kiosk, information about wait time for a medical kiosk, information as to the order of users waiting to use the medical kiosk, information about whether a medical kiosk is available or in use, cable TV, satellite TV, local broadcast TV, infomercial, medical programs, DVD materials, Blu-ray materials, etc.).", "Patients waiting to enter the medical kiosk can be allowed to view the various advertisements and/or other types of information displayed on the one or more screens; however, this is not required.", "The patients can see the wait time for their appointment and/or their position in the appointment queue when such information is displayed on the one or more video screens; however, this is not required.", "Any message necessary for the patient to see can also be displayed upon the screen in the interior of the medical kiosk; however, this is not required (e.g., “Welcome (Patient Name)”, “Your Medical Provider (Provider Name) Will Begin Your Visit Once You Have First Captured Some Basic Vitals”, etc.).", "The one or more interior screens are primarily utilized for video conferencing between the patient and the provider, patient data input, and patient instructions, but can also be used to display advertisements and/or other information during periods where the medical kiosk has no appointment queued; however, this is not required.", "The digital signage application can allow businesses to display advertisements and/or current promotions in a way that will attract the consumer's attention; however, this is not required.", "The ability to tailor the signage to individual patients and/or population groups makes it very adaptable; however, this is not required.", "The information on the display can be in any language.", "The information on the display can include subtitles, etc.", "; however, this is not required.", "In another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include an exterior check-in registration station via an integrated touch screen monitor; however, this is not required.", "The personal medical kiosk generally does not include the use of an exterior check-in registration station.", "The novel method of the present invention can include the use of a medical kiosk to enable the patient to conveniently communicate with the medical provider.", "In one non-limiting embodiment, the medical kiosk has an exterior check-in registration station.", "The check-in registration station can include a key pad and/or key board for identification and/or data entry, a touch screen for identification and/or data entry, microphone and/or voice recognition software for identification and/or data entry, fingerprint scanner for identification and/or data entry, and/or retina scanner for identification and/or entry; however, this is not required.", "As can be appreciated, other or additional devices can be included on the medical kiosk for identification and/or data entry.", "The medical kiosk having an exterior check-in registration station can be used by the patient to enter/convey basic information about the patient.", "Such information includes, but is not limited to, a) patient name, b) patient address, c) patient contact information, d) patient age, e) patient sex, f) patient height, g) patient weight, h) patient medical history, i) current medicines used by patient, j) reason(s) for visit by patient, k) patient current symptoms, l) patient insurance information, m) patient payment information, n) consent forms, and/or o) patient's current doctor.", "As can be appreciated, other or additional information can be input/conveyed by the patient.", "The medial kiosk can be designed to provide information to the patient prior to and/or during the inputting/conveying of information by the patient to the medical kiosk.", "In one non-limiting embodiment of the invention, the medical kiosk can include audio and/or visual instructions and/or displays used to provide a) information about the medical kiosk, b) how to use the medical kiosk, c) how to properly input/convey information to the medical kiosk, d) provide instructions and/or interactions with the patient during the inputting/conveying of information by the patient to the medical kiosk, e) the wait time for the patient's use of the medical kiosk, f) a list of patient's waiting to use the medical kiosk, g) the types of conditions that can be treated by the medical kiosk, h) the type of medical devices that can be used with the medical kiosk, i) how to use medical devices with the medical kiosk, j) information about who is qualified to use the medical kiosk, and/or k) information regarding whether the medical kiosk is in use or is available.", "In another and/or alternative non-limiting embodiment of the invention, the medical kiosk can include light and/or sound indicators to provide information regarding 1) whether the medical kiosk is in use or is available, 2) whether information is required to be entered and/or is improperly entered and/or correctly entered in the medical kiosk, and/or 3) whether a medical device is properly or improperly connected to the medical kiosk; however, this is not required.", "In still another and/or alternative non-limiting embodiment of the invention, the medical kiosk can include a notification system to a patient that the medical kiosk is available or will soon be available; however, this is not required.", "Such notification can be sent via email, phone, pager, internet, etc.", "Such notification system can be useful when the medical kiosk is not currently available to the patient.", "The patient can input the information into the medical kiosk and then go home, run other errands, etc., and then be later notified when the medical kiosk is available or will soon be available.", "The medical kiosk and/or notification system can also be used to inform the patient when and/or where other medical kiosks are available; however, this is not required.", "This service, when available, can be used to inform the patient that a nearby medical kiosk has a shorter wait period or is currently available, thus providing the patient with the option of traveling to another available medical kiosk instead of waiting for the current medical kiosk to become available; however, this is not required.", "This service, when available, can also be used to inform the patient when a prescription is ready for pickup and/or for conveying prescription information to the patient; however, this is not required.", "This service, when available, can also be used to inform the patient when a follow-up visit is due and/or scheduled; however, this is not required.", "As can be appreciated, the notification system can be used to provide information to patients about medication, medication compliance, when medication should be taken, or for other or additional services.", "The medical kiosk can include an exterior registration station for check-in via a touch-screen monitor (e.g., monitor, etc.).", "The exterior registration station is typically not used with a personal medical kiosk.", "The monitor or touch-screen monitor of the exterior registration station can be mounted at a height and angle that meets ADA compliance and is easily accessible to individuals in wheel chairs; however, this is not required.", "The touch screen monitor can include a built-in privacy filter for HIPAA compliance; however, this is not required.", "In one non-limiting embodiment, the front panel of the medical kiosk includes a registration station.", "The registration station can include a touch screen, a display screen, and an optional frame that such components can be mounted thereto; however, this is not required.", "The shape of the frame, when used, is non-limiting.", "The frame, when used, can be designed to be easily removed from the front panel to enable servicing, repair, replacement, etc.", "of one or more components of the registration station; however, this is not required.", "As can be appreciated, the registration station can also or alternatively include other or optional features (e.g., additional display screen, additional touch screen, lights, buttons, switches, camera, speakers, microphone, keyboard, scanner, receiver, transmitter, credit card/debit card or other some other card reader, smart phone or other smart device reader/scanner, finger and/or eye scanner, shelf, printer, storage cavity, service access door, motion sensor, sound sensor, temperature sensor, logos, etc.", "); however, this is not required.", "The touch screen, when used, is generally used to allow a user to enter in information about the user (e.g., age, sex, contact information, payment information, medical history, medical issue, etc.", "); however, this is not required.", "The touch screen can be substituted for a keyboard; however, this not required.", "The frame can be designed to mount the touch screen at some angle (e.g., 10-80) relative to the front plane of the front panel; however, this is not required.", "The frame optionally includes one or more side sections that can include one or more other or optional features of the registration station; however, this is not required.", "As can be appreciated, one or more other or optional features of the registration station can also or alternatively be located on other regions of the registration station.", "The touch screen can display various types of information (e.g., electronic keyboard, instructions on how to register, questions that are displayed during registration, instructions during registration, information displayed to user during registration, various templates, various menus, various lists of information, etc.", "); however, this is not required.", "As can be appreciated, the medical kiosk can be designed to accept voice commands during the registration process; however, this is not required.", "The display screen can be used to provide various types of information (e.g., registration information, information input by the user, advertising information, information about the medical kiosk, information about wait time for a medical kiosk, information as to the order of users waiting to use the medical kiosk, information about whether a medical kiosk is available or in use, cable TV, satellite TV, local broadcast TV, infomercial, medical programs, DVD materials, Blu-ray materials, etc.).", "Another display screen can be positioned above the screen used at the registration station and/or at some other location on the exterior of the medical kiosk; however, this is not required.", "This other display screen can be used to display various types of information (e.g., advertising information, information about the medical kiosk, information about wait time for a medical kiosk, information as to the order of users waiting to use the medical kiosk, information about whether a medical kiosk is available or in use, cable TV, satellite TV, local broadcast TV, infomercial, medical programs, DVD materials, Blu-ray materials, etc.", "); however, this is not required.", "In one non-limiting arrangement, the screen used at the registration station and the one or more other displays can be designed to display different types of information (e.g., screen used at the registration station displays information related to the registration process and the one or more other displays are used to display one or more types of information that are different from the information displayed on the screen used at the registration station, etc.", "); however, this is not required.", "The size of the screen used at the registration station and the one or more other displays can be the same or different.", "In one non-limiting arrangement, a user/patient can be allowed to enter payment information at the registration station (e.g., swipes a credit or debit card, etc.", "); however, it can be appreciated that payment information can also or alternatively be entered inside the medical kiosk, at the optional attendant station, wirelessly or over a network via a smart phone or other device or by a computer connected to a network, etc.", "If a medical attendant is available, the medical attendant can assist a user during the registration process; however, this is not required.", "Generally, the medical kiosk includes a single registration station; however, this is not required.", "As can be appreciated, the registration station can alternatively be located inside the medical kiosk, at the attendant station, on other panels or sidewalls of the medical kiosk, or located remotely from the medical kiosk (e.g., central registration center for use with multiple medical kiosks, etc.).", "In one non-limiting arrangement, the exterior check-in registration station can be designed to be easily removed from the front panel of the medical kiosk and/or be easily accessed from the interior of the medical kiosk to enable servicing, repair, replacement, etc.", "of one or more components of the registration station; however, this is not required.", "The check-in system in accordance with the present invention offers a new way for organizations to meet rising consumer expectations for convenience and, at the same time, improve accuracy and usability of information systems; however, this is not required.", "The check-in system in accordance with the present invention can result in shorter waiting times for check-in, as well as efficiency gains from increased throughput and fewer errors in keeping patient demographic data up to date; however, this is not required.", "The check-in system in accordance with the present invention can result in the reduction of risk of patient misidentification and clerical errors at data entry; however, this is not required.", "The check-in system in accordance with the present invention can improve accuracy in language access for those not fluent in English by offering multiple language options during the check-in process; however, this is not required.", "In still another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a sanitizing system (e.g., UV system, mist system, etc.)", "that can be automatically activated and/or activated by the medical attendant, when used, and/or medical provider prior to and/or after a patient has used the medical kiosk; however, this is not required.", "The personal medical kiosk generally does not include a sanitation system; however, this is not required.", "The medical kiosk can include a cleaning system designed to clean the interior of the medical kiosk and/or kill/neutralize some of or all germs and/or other microorganisms in the medical kiosk (e.g., air in the medical kiosk, one or more surfaces of the medical kiosk, one or more medical devices, etc.", "); however, this is not required.", "One non-limiting cleaning system that can be used is an ultraviolet sanitizing system.", "As can also be appreciated, a mist sanitizer can also or alternatively be used to fully or partially clean/sanitize one or more portions of the medical kiosk.", "As can be appreciated, other or additional cleaning systems can be used.", "In another and/or alternative non-limiting aspect of the invention, the medical kiosk can be made of one or more materials that resist growth of bacteria, viruses and/or other microorganisms; however, this is not required.", "In one non-limiting embodiment, the floor, walls and ceiling of the medical kiosk include or are fully made of materials that resist or prevent the growth of bacteria, viruses and/or other microorganisms; however, this is not required.", "In one non-limiting arrangement, the medical kiosk includes an ultraviolet light sanitization system which can be used in the medical kiosk and which can be activated through software from a remote location and/or by a kiosk attendant; however, this is not required.", "The ultraviolet light sanitization system can be activated twice daily to ensure the sanitary environment is maintained; however, it can be appreciated, that the ultraviolet light sanitization system can be activated a greater or lesser number of times per day.", "The location of the ultraviolet light sanitization system, when used, is non-limiting.", "In one non-limiting arrangement, the ultraviolet light sanitization system can be located in the roof or ceiling of the medical kiosk; however, this is not required.", "For example, the ultraviolet light sanitization system can be connected or positioned adjacent to the ceiling panel and rear panels; however, this is not required.", "The ultraviolet light sanitization system can be located in the rear of the medical kiosk where it will be out of the way of the patients utilizing the medical kiosk; however, this is not required.", "The ultraviolet light sanitizing system generally includes one or more ultraviolet lights that are designed to kill some or all of the germs and/or other microorganisms in the medical kiosk (e.g., air in the medical kiosk, one or more surfaces of the medical kiosk, one or more medical devices, etc.).", "The ultraviolet sanitizing system can optionally include one or more vents that allow air to flow into and/or out of the ultraviolet sanitizing system to facilitate in the cooling of the ultraviolet sanitizing system; however, this is not required.", "The sanitization system can be built with high-strength plastics and/or any other sufficiently rigid and strong material such as metal and constructed in a way preventing it from being tampered with by patients or anyone other than the attendant; however, this is not required.", "Such an arrangement, when used, can facilitate in ensuring that it is not activated incorrectly or at an inopportune time; however, this is not required.", "The shape, size and/or configuration of the built in sanitization system are non-limiting.", "The one or more medical attendants, when used, can also or alternatively clean and/or sanitize various regions of the medical kiosk prior to and/or after being used by a patient and/or set up the medical kiosk for a new user; however, this is not required.", "For example, prior to and/or after one or more patients have entered the medical kiosk, the one or more attendants can clean/sanitize one or more exterior surfaces and/or regions of the medical kiosk (e.g., medical kiosk door, medical kiosk check-in terminal, medical kiosk desk top, medical kiosk exterior walls, medical kiosk touch screen, medical kiosk monitors, seating/tables in waiting area near medical kiosk, etc.", "); however, this is not required.", "In an another and/or additional example, prior to and/or after one or more patients have entered the medical kiosk, the one or more medical attendants, when used, can clean/sanitize one or more interior surfaces of the medical kiosk (e.g., medical kiosk door, medical kiosk floor, medical kiosk bench, medical kiosk chair, medical kiosk user terminal, medical kiosk interior desk top, medical kiosk interior walls, medical kiosk touch screen, medical kiosk monitors, medical kiosk instrument doors, medical devices/instruments used by and/or touched by user when in the medical kiosk, any other surface in the interior of the medical kiosk, etc.", "); however, this is not required.", "For a personal medical kiosk, the patient can generally clean/sanitize the personal medical kiosk and/or medical devices prior to, during and/or after use of the personal medical kiosk.", "In still another and/or additional example, prior to and/or after one or more patients have entered the medical kiosk, the one or more medical attendants, when used, can set up the medical kiosk for a user (e.g., clean/sanitize interior surfaces of medical kiosk; clean/sanitize medical devices/instruments used and/or touched by a prior user; reposition medical devices/instruments into device storage areas; replace disposable components on medical devices/instruments; fix, repair and/or replace fans, UV bulbs, UV devices, etc.", "in the interior and/or exterior of the medical kiosk; refill cleaning and/or sanitizing fluid; etc.", "); however, this is not required.", "In still yet another and/or alternative non-limiting aspect of the invention, the medical kiosk can include a sanitizing system (e.g., UV system, mist system, etc.)", "that can be automatically activated and/or activated by the medical attendant, when used, prior to and/or after a patient has used the medical kiosk; however, this is not required.", "As can also be appreciated, a mist sanitizer can also or alternatively be used to fully or partially clean/sanitize one or more portions of the medical kiosk and/or medical devices.", "Generally, the germs and/or other microorganisms in the medical kiosk are treated when the interior of the medical kiosk does not include a user.", "The sanitizing system can optionally include one or more standard lights that can be used to provide illumination in the medical kiosk; however, this is not required.", "The sanitizing system can optionally include a cooling fan for the one or more components in the sanitation system; however, this is not required.", "The sanitizing system can optionally include both a UV and a mist sanitizing system; however, this is not required.", "The sanitizing system can house one or more cameras, speakers, sensors (e.g., temperature sensor, motion sensor, sound sensor, etc.", "), etc.", "for use in the medical kiosk; however, this is not required.", "The sanitizing system includes a shroud that includes vent/light/mist openings to house the components of the sanitizing system; however, this is not required.", "The shape, size and configuration of the shroud, when used, are non-limiting.", "When a mist sanitizing system is additionally or alternatively used, one or more mist nozzles can be located in one or more regions of the medical kiosk so as to direct the sanitizing mist to desired locations in the medical kiosk (e.g., onto certain surfaces of the medical kiosk, onto certain medical devices, etc.", "); however, this is not required.", "The doors to the medical kiosk can be closed and/or locked to prevent a user/patent from entering the medical kiosk during a sanitizing process; however, this is not required.", "In yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medical kiosk that enables a service operator to easily access the various components of the medical kiosk for purposes of service, repair, maintenance, upgrade, replacement, etc.", "; however, this is not required In order to offer the comprehensive services the medical kiosk is capable of, there are multiple components that must be functioning at all times; however, this is not required.", "The various devices that may need service include, but are not limited to, the display screens, the network connection, various other electronics and wiring, fans, lights, electronic switches, backup power supplies, computers, electronic storage devices, doors on the medical equipment compartments, etc.", "The ability to easily and conveniently access and/or perform maintenance on these components is advantageous to providing the medical kiosk services via the medical kiosk; however, this is not required.", "To more easily facilitate the service of these components, the medical kiosk can be designed with a moveable front panel; however, this is not required.", "The front panel can be built on casters, wheel, rail system, etc.", "to allow the front panel to be easily moved; however this is not required.", "Such an arrangement is generally not used with a personal medical kiosk; however, this is not required.", "The front panel can be equipped with a tamper-proof lock to prevent unauthorized personnel from accessing the components located behind the front panel; however, this is not required.", "A portion of or the entire front panel can be designed to move in order to ensure that when there is a problem with one or more components used in the medical kiosk, the repair of such components does not require the disassembly of the entire or a substantial portion of the medial kiosk to repair the components; however, this is not required.", "The components of the medical kiosk that are generally difficult or inaccessible when the medical kiosk is fully assemble are 1) the components that form the exterior check-in station, 2) the interior displays or monitors, 3) the interior speakers, the interior cameras, 4) the interior sound jack, 5) the doors on the medical compartments, 6) the interior microphone, 7) the electronics located behind the exterior check-in station, 8) the electronics located behind the interior AV system, and/or 9) the computer and other electronics used for network communication, control and/or storage; however, this is not required.", "As can be appreciated, there may be other or additional components of the medical kiosk that are generally difficult or inaccessible when the medical kiosk is fully assembled.", "Access to one or more of these components can be more easily accessed by the movement of the interior front panel of the medical kiosk; however, this is not required.", "In still yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a method and a medical kiosk that enables the medical provider to generate electronic prescriptions and/or for the patient to conveniently select and/or order prescription drugs; however, this is not required.", "In one non-limiting embodiment, this novel method and apparatus will allow patients to 1) choose between name brand and generic drugs, 2) choose the supply quantity for the prescription (i.e., 30 days supply, 60 days supply, 90 days supply, etc.", "), 3) choose between picking up the prescription at the pharmacy of their choice or mail delivery of the prescription, 4) enter medical insurance for partial or full payment of the prescription, 5) enter a credit or debit card information to pay for the prescription, 6) enter information for mail delivery of the prescription, 8) enter information to provide automatic reminders to patient regarding refills and/or follow-up medical visits, 9) enter information to enable a patient to be notified when a prescription has been mailed and/or is ready to be picked up at the pharmacy; however, this is not required, 10) obtain a print out and/or electronic version of the prescription written by the medical provider, and/or 11) receive information about the issued prescription (e.g., prescribed use, side effects, etc.)", "in printout and/or electronic form; however, this is not required.", "Another non-limiting aspect of this method and apparatus will allow the patient to select the pharmacy where he/she would like to pick up the prescription; however, this is not required.", "In one non-limiting embodiment of the invention, the medical provider can generate an electronic prescription for a patient.", "The prescription can include both the generic and name brand drugs along with the patient copay amount for each; however, this is not required.", "The electronic prescription can provide additional information (e.g., potential savings for selecting certain medications, the dosage amount, the medication dosage, quantity or strength, name of medical provider, help information, coupons, advertising information, etc.", "); however, this is not required.", "Once the particular medication brand is selected by the patient, another screen can optionally appear; however, this is not required.", "For example, the second screen can illustrate the brand of medication selected by the patient/user and/or also provide quantity supply options for the medication, etc.", "; however, this is not required.", "The second screen can optionally illustrate additional information such as, but not limited to, the copay amount for the selected medication brand and quantity, the monthly, yearly, etc.", "savings for selecting a particular medication brand and/or quantity, help information, go back option, advertising information, coupons, generic options for medication, etc.", "; however, this is not required.", "The second or a third screen can optionally appear that provides an order confirmation along with the associated savings; however, this is not required.", "The second or third screen can optionally illustrate additional information such as, but not limited to, the monthly, yearly, etc.", "savings for selecting a particular medication brand and/or quantity, help information, advertising information, etc.", "As can be appreciated, other or additional screens can be displayed to the user/patient.", "This aspect of the invention has the advantage of allowing the user/patient to view and/or select brand or generic drugs, thereby allowing the user/patient to decide which drug option is best for them and their budget; however, this is not required.", "The medical kiosk and method for using the medical kiosk can thus include a point of purchase prescription workflow application allowing a medical provider to generate prescriptions and optionally allowing patients to select and/or order prescription drugs; however, this is not required.", "The medical kiosk and method for using the medical kiosk can include a point of purchase prescription workflow application that allows a user/patient to choose his/her drug brand and/or quantity; however, this is not required.", "The medical kiosk and method for using the medical kiosk can include a point of purchase prescription workflow application that allows a user/patient to select the pharmacy from which to pick up his/her prescription; however, this is not required.", "In another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include headphone jacks; however, this is not required.", "The one or more headphone jacks allow for hearing-impaired patients to utilize headphones in order to better understand the provider's instructions; however, this is not required.", "The one or more headphone jacks can also be used to enable additional persons in the medical kiosk (e.g., child's parent, etc,) to listen in on the conversation between the medical provider and patient; however, this is not required.", "The one or more headphone jacks can also be used to provide additional privacy between the medical provider and patient; however, this is not required.", "The headphones may be available from the kiosk and/or the medical attendant; however, this is not required.", "The headphone jack can be placed at a height allowing any person to reach it if necessary; however, this is not required.", "The headphones generally will be sanitary either through disposable covers or through another form of sanitization; however, this is not required.", "The headphone jack can be a standard jack to enable a patient to use his/her own headphone; however, this is not required.", "The medical kiosk can include a wireless system (e.g., Bluetooth technology, IR technology, RF technology, etc.)", "to transmit sound wirelessly to a patient and/or other person located in the medical kiosk; however, this is not required.", "The kiosk can also be equipped with a wheelchair accessible ramp; however, this is not required.", "The medical kiosk can be designed to be fully ADA compliant as a result of these novel innovations; however, this is not required.", "A medical kiosk that includes one or more headphone jacks and/or a wheelchair accessible ramp can permit the medical kiosk to better serve the public at large; however, this is not required.", "In still another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medical kiosk that utilizes high definition video and/or high quality sound to create a conference link between a patient located in the medical kiosk and a medical provider that is located remotely to the medical kiosk; however, this is not required.", "In one non-limiting aspect of the invention, the medical kiosk includes the use of one or more high definition cameras, one or more high definition monitor(s) and/or high quality speaker(s) built into the medical kiosk and/or used with the medical kiosk; however, this is not required.", "The one or more cameras located on, near, or within the medical kiosk can be on an adjustable sliding bar allowing camera positioning to create ideal eye contact; however, this is not required.", "The one or more cameras in the medical kiosk can be used to enable a medical provider to obtain information about a user/patient in the medical kiosk (e.g., height, build, sex, skin color, alertness, body cuts, body infections, body rashes, pupil dilation, hygiene, race, physical condition, emotional condition, metal condition, etc.", "); however, this is not required.", "In one non-limiting arrangement, one or more monitors and/or display screens can be positioned on the front interior wall of the medical kiosk; however, this is not required.", "The monitor is generally used to view the one or more medical providers when the user/patient is located in the medical kiosk; however, this is not required.", "The shape, size, and thickness of the one or more monitors are non-limiting.", "One or more cameras can be positioned on the front interior wall, be embedded in the one or more monitor/display screens, and/or be located on a sliding bar allowing it to be positioned relative to the user/patient to create better eye contact with the user/patient in the medical kiosk; however, it can be appreciated that the one or more cameras can be located in other locations.", "The one or more cameras enable pictures of the user/patient in the medical kiosk to be transmitted to a remotely located medical provider; however, this is not required.", "The remotely located provider typically has a camera at his/her location so that pictures of the medical provider can be transmitted to the one or more medical screens in the medical kiosk; however, this is not required.", "As can be appreciated, a projector can be used as a substitute of one or more monitors in the medical kiosk; however, this is not required.", "One or more speakers can be positioned on the front interior wall of the medical kiosk; however, this is not required.", "As can be appreciated, one or more speakers can be positioned on other or additional locations in the medical kiosk; however, this is not required.", "The speakers can be used to enable a user/patient in the medical kiosk to listen to what the medical provider is saying to the user/patient; however, this is not required.", "One or more microphones are generally included in the medical kiosk to allow the user/patient to communicate with the medical provider; however, this is not required.", "In yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medical kiosk that is a modular kiosk that is able to be partially or fully broken down; however, this is not required.", "In one non-limiting embodiment of the invention, the modular medical kiosk can be partially or fully broken down so as to fit through a doorway (e.g., standard 36″ by 80″ doorway, etc.", "); however, this is not required.", "The modular design of the medical kiosk, when the medical kiosk has a modular design, can enable the medical kiosk to be set up in various configurations to enable the medical kiosk to be used in various types of spaces; however, this is not required.", "The modular design of the medical kiosk can be designed to not only accommodate multiple configurations of the medical kiosk, but can also be designed to facilitate in enabling the medical kiosk to be moved into an existing facility and then allowing the assembly of the medical kiosk in such facility without having to modifying the entry ways into or out of the facility; however, this is not required.", "The medical kiosk can be formed of any number of materials (e.g., plastic, foam, metal, wood, etc.).", "The modular configuration of the medical kiosk can be such that it can be easily assembled and disassembled so that the medical kiosk can be easily brought into a location and easily set up; however, this is not required.", "The medical kiosk can be designed to include a floor panel; however, this is not required.", "The floor panel, when used, is generally a one-piece unit; however, the floor panel can be formed of multiple pieces.", "The floor panel, when used, can be formed of a durable material (e.g., plastic, metal, wood, composite material, man-made materials, etc.).", "The floor panel, when used, can be formed of a slightly compressible material to facilitate in the comfort of walking on the floor panel; however, this is not required.", "The floor panel can have an oval shape; however, other shapes can be used (e.g., circular, square, rectangular, polygonal, etc.).", "In one non-limiting design, the maximum length of the floor panel is generally 3-15 feet, typically 4-12 feet, more typically about 6-10 feet, and even more typically about 8-9 feet; however, other lengths can be used.", "In one non-limiting design, the maximum width of the floor panel is generally 3-10 feet, typically 4-8 feet, and more typically about 4-6 feet; however; other widths can be used.", "In one non-limiting design, the top surface area of the floor panel is generally 10-150 sq.", "ft., typically 15-80 sq.", "ft., and more typically about 50-60 sq.", "ft.; however, other surface areas of the floor panel can be used.", "The floor panel can be sized to enable a user in a wheelchair to enter the medical kiosk and turn and/or fully maneuver in the medical kiosk while sitting in the wheelchair; however, this is not required.", "In one non-limiting design, the thickness of the floor panel is generally about 0.1-5 inches, and typically about 0.25-3 inches; however, other thicknesses of the floor panel can be used.", "A ramp can be optionally used to facilitate the entry and exiting of the medical kiosk; however, this is not required.", "The shape and size of the ramp are non-limiting.", "The ramp can be made of a similar material as the floor panel; however, this is not required.", "The ramp generally includes a sloped surface to facilitate in transitioning from a floor surface to the top surface of the floor panel; however, this is not required.", "The medical kiosk can optionally include one or more benches, stools and/or chairs.", "When a bench is included in the medical kiosk, the bench is generally positioned on the back interior wall of the medical kiosk; however, this is not required.", "The bench can be used to allow a parent, guardian, spouse, relative, friend, etc.", "to sit in the medical kiosk while the user is obtaining medical services in the medical kiosk.", "The bench can be designed to enable one or more persons to sit on the bench.", "The bench can optionally include a storage space under the seat of the bench that can be used to store supplies, equipment, etc.", "for the medical kiosk.", "A liftable seat section can be used to access the storage space; however, this is not required.", "When the bench includes a storage space, the bench can include a lock to limit access to the storage space; however, this is not required.", "As can be appreciated, the medical kiosk can include one or more chairs (not shown) to enable one or more users to sit in the medical kiosk while receiving medical services in the medical kiosk; however, this is not required.", "The bench is generally about 10-25 inches high, and typically about 16-20 inches high; however, other heights can be used.", "In one non-limiting arrangement, the medical kiosk can include two front panels, two rear panels, one side wall, and one door system; however, this is not required.", "The front panels, rear panels, side wall, and door system are generally formed of a durable material (e.g., plastic, metal, wood, composite material, man-made materials, etc.).", "As can be appreciated, the medical kiosk can be designed to only include a single front panel and/or a single rear panel.", "As can also be appreciated, the medical kiosk can be designed to include more than two front panels and/or more than two rear panels.", "As can be appreciated, the medical kiosk can be designed to include more than one side wall and/or more than one door system.", "As can also be appreciated, a side wall can be substituted for another door system; however, this is not required.", "The general shape and size of the front and rear panels are the same; however, this is not required.", "The shape of the front and rear panels can be arcuate; however, this is not required.", "The radius of curvature the front and rear panels can be about 10-100 inches, typically 15-50 inches, and more typically about 20-35 inches; however, other radius of curvatures can be used.", "The front and rear panels can have an angle of curvature of about 90° or a quarter of a circle; however, it can be appreciated that one or both rear and/or front panels can have different angles of curvature.", "The general shape and size of the side wall and the door system are generally the same; however, this is not required.", "The side wall and door system can lie in a generally flat plane; however, this is not required.", "The front and rear panels and the side wall and door system can form a generally oval shape for the medical kiosk; however, this is not required.", "The two front panels and two rear panels can have the same or similar footprint; however, this is not required.", "The side wall and the door system can have the same or similar footprint; however, this is not required.", "The similarity in the shape and footprint of the wall components of the medical kiosk, when used, enables the medical kiosk to be assembled in a manner that is convenient for the facility that will include the medical kiosk.", "For example, if the door system needs to be positioned on the left side of the medical kiosk, instead of the right side, the similarly shaped side wall and door system enables the medical kiosk to be assembled in such a manner.", "Also, if the optional registration station of the medical system needs to be placed on the left side or right side or on the rear end of the medical kiosk instead of the front end, the similarly shaped front and rear panels can be easily exchanged to create such configuration for the medical kiosk.", "The modular medical kiosk not only accommodates multiple configurations of the medical kiosk, it also can facilitate in enabling the medical kiosk to be moved into an existing facility and then assembling the medical kiosk in such facility without having to modify the entryways into or out of the facility; however, this is not required.", "The thickness and height of the front panels, rear panels, side wall and door system are non-limiting.", "In one non-limiting embodiment, the maximum height of the front panels, rear panels, side wall and door system is about 5-12 ft., typically about 6-9 ft., and more typically about 7-8 ft.; however, other heights can be used.", "In one non-limiting embodiment, the thickness of the front panels, rear panels, side wall and door system is generally about 0.5-10 inches, typically about 1-5 inches, and more typically about 1-2 inches; however, other thicknesses can be used.", "The front panels, rear panels, side wall and door system can optionally include insulation, sound dampening material, etc.", "; however, this is not required.", "The front panels, rear panels, side wall and door system can be designed to be connected together in a variety of ways (e.g., bolted/screwed together, latched together, snap fitted together, press fitted together, etc.).", "Generally, the arrangement is used to connect together the front panels, rear panels, side wall and door system to enable easy connecting and disconnecting of the front panels, rear panels, side wall and door system from one another.", "One or more of the front panels, rear panels, side wall and door system can include openings, windows, transparent/semi-transparent regions that allow for ventilation, illumination, and/or viewing; however, this is not required.", "Generally, front panels, rear panels, side wall and door system are mostly or fully formed of opaque or non-transparent materials so as to ensure the privacy of the user in the medical kiosk; however, this is not required.", "The configuration of the door system is non-limiting.", "The door system can include a frame and two doors; however, it can be appreciated that the door system only includes a single door.", "Each door can include a handle or grasp cavity on one or both sides of the one or both doors.", "The one or more doors can be designed to open and close in a variety of ways (e.g., swing open and closed, slide open and closed on a top/bottom rail system, etc.).", "As can be appreciated, the one or more doors for the medical kiosk can also or alternatively be positioned on one or more of the front or rear panels; however, this is not required.", "In one non-limiting embodiment, the maximum height of the doors is generally about 5-9 ft., and typically about 6-7 ft.; however, other heights can be used.", "In one non-limiting embodiment, the maximum width of the entry provided by the one or more doors when fully open is generally about 15-60 inches, typically about 25-55 inches, and more typically about 30-50 inches; however, other widths can be used.", "The door opening is generally selected to enable a standard wheelchair to pass through the opening; however, this is not required.", "The medical kiosk can optionally include an exterior attendant station that is connected to and/or positioned near the medical kiosk.", "The exterior attendant station can be used by one or more medical attendants, medical providers, etc.", "A desk can be connected to and/or positioned next to an exterior wall of the medical kiosk; however, this is not required.", "The desk, when used, can be formed of one or more pieces.", "When the desk is designed to be connected to an exterior wall of the medical kiosk, such connection arrangement is not limited (e.g., screw, bolt, clamp, press fit, snap arrangement, etc.).", "The desk can include a desk top, one or more legs, one or more shelf regions, one or more drawers, etc.", "; however, this is not required.", "One or more chairs (not shown) can be used to allow one or more medical attendants, medical providers, etc.", "to sit at the desk; however, this is not required.", "The desk, when used, can be positioned at or adjacent to one or both front panels; however, this is not required.", "The desk can be designed to include one or more drawers, shelves, doors, etc.", "One or more locks can be included on the desk; however, this is not required.", "The desk can be used to support a monitor, computer, power supply, power strip, printer, router, network switcher, key board, mouse, printer paper, medical supplies, sanitation supplies, refrigerator, freezer, scanner, credit card/debit card reader, data port, lights, desk supplies, etc.", "The freezer and/or refrigerator, when used, can contain immunizations, medications, urine samples, blood samples, etc.", "In still yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medical kiosk that includes a ceiling panel; however, this is not required.", "The ceiling panel can be formed of one or more pieces.", "The ceiling panel can be formed of a transparent or semi-transparent material to allow light to enter and illuminate the interior of the medical kiosk; however, this is not required.", "In still yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medical kiosk that is made of one or more materials that resist or prevent the growth of bacteria, viruses and/or other microorganisms; however, this is not required.", "In one non-limiting embodiment, the floor, walls and ceiling of the medical kiosk include or are fully made of materials that resist or prevent the growth of bacteria, viruses and/or other microorganisms; however, this is not required.", "In still another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medical kiosk that includes a payment center that enables a user to pay for medical services, prescriptions, medical equipment, medical accessories, etc.", "prior to and/or after the user uses the medical kiosk; however, this is not required.", "The payment center can be in any form (e.g., credit card reader, mobile phone scanner, transmitter/receiver device, electronic scanner, cash receiver, etc.).", "The payment center may include a touch pad, keyboard, scanner, receiver, transmitter, credit card/debit card or some other card reader, smart phone or other smart device reader/scanner, finger and/or eye scanner, monitor, chair, table, shelf, printer, instructions on how to use the payment center, etc.", "The payment center can be located on the exterior and/or interior of the medical kiosk.", "Generally, the user is required to register and pay for the medical services prior to obtaining medical services from the medical provider; however, this is not required.", "In one non-limiting arrangement, the medical kiosk includes a registration station on the exterior of the medical kiosk (e.g., exterior wall of the medical kiosk, on a table exterior to the medical kiosk, etc.", "); however, this is not required.", "As can be appreciated, a user can be allowed to wirelessly connect to the medical kiosk or to some other computer network so as to wirelessly register and/or enter payment information for use of the medical kiosk; however, this is not required.", "In such an arrangement, a user could register to use a medical kiosk, enter in payment for use of the medical kiosk, set an appointment time for use of the medical kiosk, select a particular medical kiosk to use at some particular location, etc.", "at some location near or remote from the medical kiosk via a smart phone or other smart device, a computer, etc.", "In yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medical kiosk that includes an interior cavity or room that provides privacy to the patient when inputting and/or conveying data to the medical kiosk, and/or communicating with a medical provider via an audio and/or video link; however, this is not required.", "The size, configuration and/or arrangement of the interior cavity or room are non-limiting.", "The interior cavity or room can include a) one or more speakers, b) one or more microphones, c) one or more video displays, d) one or more data input device, e) one or more chairs and/or other types of seating areas, f) one or more tables, g) one or more doors, h) one or more shelves, i) one or more compartments used to contain medical supplies, medical instruments, etc., j) one or more light switches, k) one or more power outlets, l) sterilization system, m) one or more headphone jacks, n) one or more lights, o) one or more table tops, p) one or more chair and/or benches, q) one or more doors, r) one or more windows, s) walls, floor and/or ceiling, t) one or more vents, u) one or more power outlets, v) one or more light and/or power switches, w) one or more USB and/or data connection outlets, and/or x) one or more fans.", "As can be appreciated, the interior cavity or room can include other or additional items.", "The size and configuration of the interior cavity or room can be designed to enable wheelchair access and maneuvering inside the interior cavity or room; however, this is not required.", "For example, the interior cavity or room can be designed to enable a standard wheelchair to move 90°, 180° and/or 360° while in the medical kiosk.", "The size and configuration of the interior cavity or room can be designed to provide sufficient room for the patient so that the patient can easily move within the interior cavity or room and/or the patient does not feel cramped or claustrophobic when in the interior cavity or room; however, this is not required.", "In still yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be designed to provide a convenient and low-cost structure (e.g., medical kiosk) that can be placed in many different locations, and which enables patients to conveniently access and obtain medical advice and/or care; however, this is not required.", "Medical providers that are located locally and/or throughout the world can be used to communicate with the patient accessing the medical kiosk.", "As such, the medical services can be offered year around and at all times so long as there is a qualified medical provider somewhere in the world that is available and is qualified to provide medical assistance via the medical kiosk.", "Such an arrangement can be more convenient to the medical provider since the medical provider can work from home or from some other convenient location.", "The arrangement is also convenient to the patient since the patient can access medical assistance via the medical kiosk at the time and place of choosing.", "Indeed, in rural areas or smaller communities that do not have a local hospital or local doctor's offices nearby, the installation of a medical kiosk in the local drug store, department store, grocery store, etc., results in more accessible and timely medical care for patients in such communities.", "The costs associated with providing medical care via the medical kiosk may be less than if the patient seeks medical assistance from a hospital, clinic or doctor's office, thus resulting in the patient potentially saving money.", "As can be appreciated, other or additional advantages may exist by the method of the present invention.", "In another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of a mobile device (e.g., smart phone, tablet, Ipad, Ipod, PDA, etc.)", "and/or computer (e.g., desktop computer, laptop computer, ultralight computer, notepads, etc.", "), home PC, smart TVs, and/or entertainment console [e.g., Xbox systems, PS3, PS4, Apple TV, Amazon Fire TV, etc.", "], etc., or any other device that can access a phone, satellite and/or the internet to enable a patient to 1) conveniently locate an available medical kiosk, 2) schedule an appointment (e.g., date and/or time), 3) pre-register symptoms and/or reasons for visit, 4) set and/or cancel an appointment, 5) received reminders and/or updates regarding appointments, 6) obtain information about medical kiosk availability, 7) obtain information about certain medical provider availability, 8) obtain information about the available medical provider (e.g., name, specialty, etc.", "), 9) enable the selection of a certain medical provider and/or medical provider in a certain field of medicine, 10) obtain map information, address information and/or hours of operation information regarding selected medical kiosk, 11) locate closest kiosk and/or kiosk availability for a certain medical provider and/or medical provider in a certain field of medicine, 12) presubmit and/or preclear medical insurance, 13) submit payment information, 14) receive information on payment status, 15) receive information on insurance coverage, 16) receive appointment reminders and/or updates, 17) receive prescription information, 18) submit payment information for medical visit and/or prescription, 19) answer surveys regarding the use of the medical kiosk, 20) receive medication reminders, 21) obtain payment from patient, and/or other types of information as previously mentioned above; however, this is not required.", "The size, shape, configuration and look of the medical kiosk are non-limiting.", "In one non-limiting embodiment, this invention will allow patients to schedule appointments using a patient portal through a computer and/or mobile device; however, this is not required.", "Another non-limiting aspect of the application will allow the patient to select the kiosk location for their appointment.", "While selecting their appointment time and/or location, the patient can also fill out the symptom survey, select the time of their appointment, and/or select a physician if they choose; however, this is not required.", "The application can also allow the patient to receive appointment reminders via mobile device, smart device, text, phone, cell-phone, web-page, Facebook, twitter, and/or email; however, this is not required.", "The application may also allow for patients to cancel and/or change their appointment; however, this is not required.", "In still another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a mobile application for a mobile device (e.g., smart phone, tablet, Ipad, Ipod, PDA, blackberry device, mobile note device, Kindle device, Nook device, etc.)", "and/or computer (e.g., desktop computer, laptop computer, ultralight computer, notepads, etc.", "), home PC, smart TVs, and/or entertainment console [e.g., Xbox systems, PS3, PS4, Apple TV, Amazon Fire TV, etc.", "], etc.", "or any other device that can access a phone, satellite and/or the internet to a portable device that, when launched, gives the user a series of options that can include, but are not limited to, finding a medical kiosk (e.g., medical kiosk, etc.", "), set medication reminders, visit the home page of the medical kiosk operator, etc.", "; however, this is not required.", "As can be appreciated other and/or additional information can be included on the welcome screen of the mobile application and/or computer-based application.", "The mobile application and/or computer based application can be designed to enable a user to 1) search or and/or locate medical kiosks in one or more communities, towns, cities, states, countries, etc., 2) determine the distance a patient is from a medical kiosk, 3) obtain the directions to a medical kiosk, 4) view the waiting status and/or availability of a particular medical kiosk, 5) obtain a map to the selected kiosk, 6) obtain information about the hours available for the medical kiosk, 7) obtain information about the actual location picture of the medical kiosk, 8) make an appointment with the medical kiosk, 9) obtain information on the hospitals and/or medical providers associated with the medical kiosk, 10) obtain information on which insurance carriers provide coverage for use of the medical kiosk, 11) obtain information on whether a particular medical provider is part of the medical kiosk network of medical providers, 12) obtain public comments about the medical kiosk, 13) contact a helpdesk that provides information about the medical kiosk, 14) schedule an appointment (e.g., date and/or time), 15) pre-register symptoms and/or reasons for visit, 16) enter information required to create an appointment (e.g., personal information, date and time of appointment, particular medical kiosk, particular medical provider, insurance information, payments, ID verification, insurance card, etc.", "), 17) set and/or cancel an appointment, 18) receive reminders and/or updates regarding appointments, 19) obtain information about the available medical provider (e.g., name, specialty, etc.", "), 20) enable the selection of a certain medical provider and/or medical provider in a certain field of medicine, 21) locate closest kiosk and/or kiosk availability for a certain medical provider and/or medical provider in a certain field of medicine, 22) presubmit and/or preclear medical insurance, 23) submit payment information, 24) receive information on payment status, 25) receive information on insurance coverage, 26) receive appointment reminders and/or updates, 27) receive medication reminders, 28) receive visit summaries, 29) obtain/review physician/provider ratings from other users or sources, 30) rate/review physician/provider, and/or any other information as mentioned above; however, this is not required.", "In one particular non-limiting arrangement, the mobile application and/or computer-based application enables a user to schedule an appointment at a medical kiosk.", "The creation of the appointment can be designed to enable the user to a) select the day and/or the time of the appointment, b) select a particular medical provider or type of medical provider (e.g., pulmonary doctor, gynecologist, etc.", "), c) provide a reason for visit and/or provide the user's symptoms, and/or d) set appointment and medication reminders; however, this is not required.", "As can be appreciated, other and/or additional information can be inputted by the user when making an appointment (e.g., sex, age, weight, height, medical history, use of current medications, symptom, allergies, etc.).", "The mobile application and/or computer-based application can be designed to create an appointment confirmation screen along with text and/or email reminder options; however, this is not required.", "The confirmation screen, when provided, can provide information about the medical provider; however, this is not required.", "The confirmation screen, when provided, can be designed to enable the patient to change/cancel the appointment; however, this is not required.", "Several non-limiting advantages of the present invention include allowing a patient to decide which kiosk location is most convenient for the patient.", "The mobile application and/or computer-based application may include an override for “first available” in regards to physician selection; however, this is not required.", "The patient also may be able to check availability of a preferred medical provider and/or the kiosk location; however, this is not required.", "In yet another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a Provider Application wherein the medical provider can contact another medical provider during a patient visit if a special need or question arises during the patient visit wherein the medical provider believes and/or the patient requests a second opinion and/or an opinion from a specialist; however, this is not required.", "The Provider Application can be designed to enable two or more medical providers to be simultaneously viewed and/or heard by the patient in the medical kiosk; however, this is not required.", "The Provider Application can be designed to allow only one medical provider at a time to be viewed and/or heard by the patient in the medical kiosk; however, this is not required.", "The Provider Application can be designed to allow an interpreter to appear to the medical provider and/or patient (e.g., language translator, sign language translator, etc.", "); however, this is not required.", "The Provider Application can be designed to allow a medical provider to contact another party (e.g., patient, guardian, relative, etc.)", "to obtain information, authorization, etc.", "about/for a patient using the medical kiosk; however, this is not required.", "In still yet another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include an Administrator Application allowing a medical administrator to remotely access one or more components of the medical kiosk; however, this is not required.", "The Administrator Application can optionally include one or more functions selected from the group consisting of 1) allowing remote access to one or more medical devices in the medical kiosk, 2) allowing remote access to one or more computers in the medical kiosk, 3) allowing remote access to one or more routers in the medical kiosk, 4) allowing remote access to one or more displays on the medical kiosk, 5) allowing remote access to one or more power supplies in the medical kiosk, 6) allowing remote access to one or more servers in the medical kiosk, 7) allowing remote access to one or more hard drives in the medical kiosk, 8) allowing diagnostics to be executed from a remote location on one or more electronic components in the medical kiosk (e.g., computer, router, server, battery backup, hard drive, medical devices, electronic locks, fans, displays, speakers, camera, headphone jack, electronic scale, Bluetooth devices, lights, pumps, scanners, touch pad, ID verification devices, printer, etc.", "), 9) allowing the rebooting and/or reinitializing from a remote location of one or more electronic components in the medical kiosk, 10) allowing for review of the current and/or past status from a remote location of one or more electronic components in the medical kiosk, 11) allowing hardware and/or software updates to be remotely sent and/or loaded onto one or more electronic components in the medical kiosk, and/or 12) allowing software to be loaded onto and/or removed from one or more electronic components in the medical kiosk.", "In another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a pharmaceutical dispensing system that dispenses medications to the patient; however, this is not required.", "The pharmaceutical dispensing system can be located on the medical kiosk or be a unit separate from the medical device.", "The pharmaceutical dispensing system can be designed to allow the patient to obtain the medication with or without the assistance of the medical attendant.", "The pharmaceutical dispensing system can be designed to only dispense medication that was authorized by the medical provider.", "In one non-limiting arrangement, the medical provider can use the Provider Application to send instructions to the pharmaceutical dispensing system to dispense certain types and/or amounts of medication to the patient; however, this is not required.", "Such information can be stored by the medical provider in the patient's record; however, this is not required.", "The medical provider can send notification to the medical attendant that medication is being dispensed to the patient; however, this is not required.", "The sent information can include type and/or quantity of medication; however, this is not required.", "Non-limiting medication and/or other materials that can be dispensed by the pharmaceutical dispensing system include antibiotics, aspirin, hydrocodone, simvastatin, Lisinopril, levothyroxine sodium, amlodipine besylate, omeprazole, Azithromycin, Amoxicillin, metformin, Hydrochlorothiazide, Lipitor, Nexium, Plavix, Advair Diskus, Abilify, Seroquel, Singulair, Crestor, Actos, Epogen, Band-Aid, tissue, alcohol wipe, bandage, cold pack, heating pad, etc.", "The payment for medication and/or materials from the pharmaceutical dispensing system can be by mobile device, payment at the medical kiosk, payment at attendant's station, and/or payment at the pharmaceutical dispensing system and/or by some other method and/or at some other location.", "In still another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a data port and/or wireless receiver that can be used by a patient to download and/or upload information to a medical device on a patient (e.g., heart monitor, heart pacemaker, implantable cardioverter defibrillators, pulse monitor, activity monitor, temperature monitor, etc.", "); however, this is not required.", "Such information can be designed to be viewed by the medical provider, and/or data can be sent to the medical device by the medical provider; however, this is not required.", "In yet another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be designed to be transported to various locations to be used in an emergency medical station; however, this is not required.", "For example, after a natural disaster (e.g., flood, hurricane, tidal wave, earthquake, fire, tornado, etc.", "), the medical kiosk of the present invention can be transported to the area of the incident and then be used as an emergency medical station.", "As can be appreciated, the medical kiosk can be continuous transported to various locations (e.g., remote rural locations, camp sites, etc.)", "to enable individuals in such locations to obtain medical assistance.", "In still yet another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be designed to allow patients to rate the medical provider and/or to view the ratings of medical providers that have offered services to patients in the medical kiosk; however, this is not required.", "Such ratings can be used by patients to select a certain medical provider for a visit, if such option is available.", "In another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be designed to allow patients to rate the experience received in the medical kiosk and/or to view the ratings of other patients that have used the medical kiosk; however, this is not required.", "In still another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be designed to automatically order supplies for the medical kiosk based on the usage of the medical devices in the medical kiosk; however, this is not required.", "For example, the number of patients using the medical kiosk can be monitored.", "If a thermometer was used for every visit, a software program can be used to automatically order the disposable component of the thermometer after a certain number of patients have visited the medical kiosk; however, this is not required.", "In another and/or additional example, software can be used to monitor the number of times a medical door for a medical device has been opened.", "Based on such number of door openings, a software program can be used to automatically order the disposable component of the medical device in a certain medical compartment after a certain number of door openings has been detected; however, this is not required.", "In still yet another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be designed to generate a fresh scent in the medical kiosk and/or select the background music/sound in the medical kiosk and/or select the lighting level in the medical kiosk and/or select the lighting color in the medical kiosk; however, this is not required.", "The type of scent and/or method of scent delivery are non-limiting.", "The type of lighting and/or light colors available are non-limiting.", "The type of music and/or sound available are non-limiting.", "In another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be designed to collect information about patients, patient retention, and/or patient referrals for use in the marketing of the medical kiosk and/or to improve/alter/enhance the services provided by the medical kiosk; however, this is not required.", "In still another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be designed to print and/or send coupons, advertisements, marketing literature, and/or medical literature to a patient that has used the medical kiosk and/or has registered with the medical kiosk; however, this is not required.", "Such coupons, advertisements, marketing literature, and/or medical literature can be general in nature and/or targeted to the particular patient and/or type of diagnoses received by the patient.", "For example, if a prescription has been written by the medical provider, one or more pharmacies may have a coupon sent to the patient to provide the patient with a discount, etc.", "if the patient fills the prescription at the pharmacy; however, this is not required.", "In yet another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be designed to facilitate in scheduling a patient for a tele-medicine visit into a remotely located healthcare kiosk; however, this is not required.", "Such process can become quite complicated.", "There can be multiple kiosks, multiple healthcare providers, various regulatory requirements which may limit services in various locations, and/or patient-specific information or requests which may limit available providers.", "In one non-limiting embodiment of the invention, there is provided a system, method and apparatus that can streamline, speed up, and/or reduce wasted time for scheduling tele-medicine patient-provider visits in multitude of remotely located (or home/mobile based) medical kiosks by automating aspects that assist medical providers in managing waiting queues of patients.", "The system, method and apparatus of the present invention can also and/or alternatively assist patients with information about expected wait times.", "The system, method and apparatus of the present invention can also and/or alternatively use wait queuing and/or reservation scheduling for a medical kiosk.", "The system, method and apparatus of the present invention can also and/or alternatively sort patients by insurance provider and/or type of insurance.", "This information can be used to identify one or more medical providers that accept the insurance of the user.", "The information can also or alternatively be used to inform the patient that the user's insurance is not acceptable.", "The information can also or alternatively be used to inform the patient of the amount of payment of the visit based on various factors (e.g., type of insurance, insurance copay amounts, whether insurance is acceptable, type of medical provider requested, a request for a particular medical provider, time of appointment, day of appointment, type of medical condition, etc.).", "In accordance with one non-limiting aspect of the present invention, when a patient checks in to a medical kiosk, the patient is automatically placed into a wait queue.", "Once in the wait queue, one or more medical providers can see the patient in a queuing application based upon configurable patient filtering parameters.", "A medical provider can then optionally start a telehealth visit directly from the queuing application with a “ready” patient.", "If wait times exceed a configurable limit, an alarm can be designed to optionally be initiated to alert medical providers of available patients.", "Patients and providers may optionally use a time slot reservation system in tandem with the wait queue using an auto insert algorithm which inserts a patient into the queue at an appropriate time to meet the reserved time slot.", "This system has several non-limiting advantages.", "For example, patients who check in to a remotely located healthcare kiosk are automatically placed into a wait queue.", "Also, medical providers can optionally see patients who are checked into each healthcare kiosk based on the provider's access credentials.", "Furthermore, patients can optionally be filtered from provider view based upon their location, insurance, medical condition, age, and/or service desired.", "Also, medical providers can optionally have a profile of patient types they are eligible to see which assists in the filtering of patients in the wait queue.", "Furthermore, multiple medical providers can optionally see patient status as checked in, and/or in a ready state along with a patient wait timer.", "Also, patients are optionally sorted by wait time in ready state to make it easy for the provider to find the next available patient with the longest wait time.", "Still further, medical providers can optionally view patient medical history prior to a visit starting if the patient has elected to share their patient medical history with the unknown provider.", "Also, a configurable alarm when a patient is ready to be seen can optionally sound, text, and/or email a medical provider regarding the patient status.", "Also, a configurable alarm for a system administrator can optionally sound if the service level has passed a configurable limit.", "Furthermore, patients can optionally receive an estimated wait time based on an algorithm of past average wait time data in relation to the number of patients ahead in the queue for the given healthcare kiosk.", "Also, patients can optionally reserve a queue “slot” for a set time in the future at a given medical kiosk online, on a mobile device, and/or at the healthcare kiosk.", "Furthermore, when the wait queue at the medical kiosk reaches the time where the patient with a queue slot should be inserted into the queue (according to an algorithm which can estimate the appropriate insertion time), the patient can optionally be automatically inserted into the queue in order to be ready at the appointed reservation slot time.", "Also, the wait queue for a given medical kiosk, or network of kiosks can optionally be modified by an administrator to accommodate no-shows, or late patients/medical providers.", "Furthermore, medical providers can optionally schedule a queue slot for a given patient at a given medical kiosk.", "The reservation system of the present invention can be used to automatically insert the patient at the appointed time to meet the reservation.", "Using the system, method and apparatus of the present invention, the specific scheduling provider can be the only provider who is able to see the given patient in the queue; however, this is not required.", "In prior art health care queuing systems, the patient selects a specific provider in advance of the visit.", "In accordance with the present invention, the medical provider may not be known in advance to the patient, thus the scheduling system allow for a more efficient scheduling of appointments.", "Prior art systems do not deal with the complexity of scheduling a multitude of medical kiosks with specific locations with various network parameters, across a multitude of providers.", "The queuing method of the present invention enables the maximum throughput of patients at a medical kiosk.", "The prior art systems do not instruct on the auto insertion of a patient in a queue based on anticipated visit time.", "A system, method and apparatus of the present invention can streamline, speed up, and/or reduce wasted time for scheduling tele-medicine patient-provider visits in multitude of remotely located (or home/mobile based) medical kiosks by automating aspects that assist medical providers in managing waiting queues of patients.", "In another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include software that can be loaded into existing software (e.g., EPIC, etc.)", "used by a medical provider, hospital, insurance company, medical group, pharmacy, etc.", "so as to create a portal, link, etc.", "to the software used to perform the tele-med services of the present invention.", "The loaded software could be designed to create a widget on the screen of the medical provider, hospital, insurance company, medical group, pharmacy, etc.", "and the clicking of the widget activates the tele-med software on the computer and/or accesses another location to enable the user to perform the tele-med services, access records, view appointments, etc.", "In yet another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medical kiosk that includes a medical device panel and associated software to aggregate a plurality of medical devices into a single medical device panel and software system; however, this is not required.", "In the past, getting multiple manufacturers' APIs for controllable medical devices approved to work within an MDDS has proved challenging.", "Medical devices require FDA clearance to be used.", "Integrating multiple devices from various manufacturers can create significant challenges for a system integrator or solution provider that is trying to provide a good user experience and remain FDA compliant.", "In most cases, the manufacturer's API does not conform to the integrators needs.", "In accordance with one non-limiting embodiment of the invention, there is provided a system, method and apparatus that can create a standalone FDA- or other type of agency-approvable medical device control panel with a configurable user interface to adapt and harmonize with related software solutions, to interface directly with multiple third-party manufacturer's device integration APIs, and/or to reside as a completely separate module within a larger telehealth software solution.", "In one non-limiting aspect of the present invention, the medical device control panel software is a separate and standalone solution that can be seamlessly incorporated into a larger software solution.", "A system integrator or solution provider can use the control panel to aggregate multiple medical device APIs into a single medical device control software (with modular aspects for various devices) with configurable user interface, to keep all aspects of device control separate from any other software, limiting the FDA or other agency's approval process to this single piece of software.", "Another and/or alternative non-limiting aspect of the present invention is to create a development kit for device manufacturers to create medical device APIs within the architecture of this solution so that configurable medical device controls can easily be shared with various system integrators and the FDA or other agency's approval remains with the original device manufacturer.", "In another non-limiting aspect of the present invention is the ability of a medical provider to optionally remotely control a device through the medical device control panel using an FDA cleared method.", "In addition and/or alternatively, it is possible for the patient to also or alternatively optionally controls the medical device through the medical device control panel.", "Still another and/or alternative non-limiting aspect of the present invention is to optionally send the device data from the control panel directly to an EMR and/or PHR.", "Currently, medical devices that are integrated within a software, wherein the software user interface for device controls has been modified from those originally provided by the device manufacturer, require that the entire software is regulated by the FDA or other government agency.", "The present invention separates the medical device(s) from the overall software solution and allows for a configurable user interface across multiple medical devices, thus eliminating the need to change code in the main non-device software applications, and streamlining FDA or other agency regulatory concerns.", "A development toolkit for device manufacturers can optionally be provided that can be used to create medical device control “widgets” that are reusable and configurable for various system integrators so that the original device manufacturer retains FDA approval or ownership of the device.", "The segmentation of devices requiring various levels of FDA or other agency regulation can coexist in the same control panel.", "A software solution provider can be able to have configuration control of the user interface of a medical device manufacturer's software.", "The medical device control panel solution can be designed to reside in the provider application and the patient application which can be managed locally or in the cloud, separate from the main telehealth application.", "The present invention makes it much easier to gain FDA or other agency clearance for FDA or other agency medical devices where the system integrator or solution provider is not the manufacturer of the device.", "The FDA or other agency controlled aspects of the software can be kept within a single or modular separate software sharing a common medical device control architecture.", "The user interface can be controllable by the medical device control panel software component within the total solution without impacting the FDA or other agency clearance of the devices.", "If the device manufacturer uses the development kit, the medical device API and user interface can be easily reused by multiple solution providers with this invention.", "FDA or other agency clearance and registration can optionally become streamlined for medical device integration of companies using this solution.", "The user interface and usability of devices can be improved by use of the present invention.", "The medical device control panel can optionally be battery and/or USB powered for maximum portability or minimum complexity.", "The present invention is directed to a system, method and apparatus that can create a standalone FDA or other type of agency approvable medical device control panel with a configurable user interface to adapt and harmonize with related software solutions, to interface directly with multiple third-party manufacturer's device integration API's, and to reside as a completely separate module within a larger telehealth software solution.", "In still another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a personal medical kiosk that can be used with one or more medical devices.", "In one non-limiting aspect of the invention, there is provided a personal medical kiosk that can be used with a plurality of medical devices that can be contained in a common housing.", "The multipurpose home and/or mobile medical device is designed to be simple to use.", "Most medical devices that are available are single purpose devices that are expensive, and are not necessarily intuitive for a casual or lay user.", "Prior art tele-medicine technologies have attempted to bring a healthcare visit into the home, or mobile device.", "The problem with this type of visit is that the medical provider may not be able to gather enough information about the patient's condition with just a videoconference.", "As a result, many medical device manufacturers have begun developing and selling medical devices that can be connected to a mobile device or to a home PC.", "These devices are commonly developed as “point solutions”, meaning they attempt to solve the problem from the device manufacturer's point of view—using a single device and the device software to connect to an often proprietary physician group—rather than having a mass market approach where the device can become part of another software solution.", "One major reason that the market has developed this way is because of the difficulties in FDA regulation requiring telehealth technology companies to solve complicated regulatory challenges.", "In one non-limiting aspect of the invention, there is provided a multipurpose home and/or mobile medical device that combines a plurality of medical devices into a common housing.", "The multipurpose home and/or mobile medical device is designed to be simple to use.", "The multipurpose home and/or mobile medical device is designed to leverage electronics, communications/connectivity.", "The multipurpose home and/or mobile medical device can also be designed to leverage FDA regulatory clearance of the medical devices.", "The multipurpose home and/or mobile medical device can connect via one or more known interfaces such as, but not limited to, USB, HDMI, Firewire, Bluetooth, IR, wireless technologies, etc.", "In one non-limiting arrangement, the multipurpose home and/or mobile medical device includes some combination or subset of at least two of the following devices: stethoscope, otoscope, dermascope, thermometer, blood pressure, pulse oximeter, ECG, spirometer, and glucometer.", "The multipurpose home and/or mobile medical device can be designed to collect vital information and/or gather images so that a remotely located healthcare provider can be provided with such collected information and make a sound and informed diagnoses of various conditions.", "The multipurpose home and/or mobile medical device can be designed to be simple enough for a patient to use on themselves in a consultation with a provider.", "The data from the multipurpose home and/or mobile medical device can optionally be shared real time, near real time, and/or asynchronously.", "The multipurpose home and/or mobile medical device can optionally be used by the patient to chronicle their vitals and/or capture images of the progress of their condition.", "The multipurpose home and/or mobile medical device can optionally include one or more methods for collecting data in a single housing.", "The patient (user) typically pairs their multipurpose home and/or mobile medical device with a mobile device (e.g., smart phones, tablets, laptop computers, notepads, etc.", "), home PC, and/or entertainment console (e.g., Xbox systems, PS3, PS4, etc.", "), or any other device that can connect to a phone, satellite and/or internet and which allows the multipurpose home and/or mobile medical device to provide data to a medical device software residing on one of these technologies and which controls the display and routing of the data.", "Some aspects of the multipurpose home and/or mobile medical device can optionally be remotely controlled by the healthcare provider.", "The medical device of the present invention combine multiple devices into a single unit for providing the most commonly needed data points for a telehealth medical visit.", "The medical devices can streamline electronics, connectivity and mechanical properties, as well as FDA or other agency registration, by sharing services and capabilities as much as possible.", "The device will minimize the space needed to store all the devices.", "The medical device of the present invention can serve more than one purpose while the prior art is single purpose built.", "The device of the present invention enables one time set-up for connectivity while the prior art requires connectivity for multiple devices.", "The device of the present invention can require a single FDA or other agency registration while the prior art requires FDA or other agency registration for multiple devices.", "The device of the present invention can leverage a medical device control panel software to maximize flexibility, minimize device costs and maximize user experience, while simplifying FDA or other agency regulatory matters.", "This invention can potentially dramatically reduce the cost of having a home telehealth visit and can also or alternatively potentially dramatically improve the quality of the visit.", "In yet another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can enable a patient to create, own, access and/or enable third parties to access and/or modify the patient's own Patient Health Record (PHR).", "Sharing patient data to healthcare provider networks has created some interesting challenges.", "The traditional model is for a patient to have a HIPAA-based privacy practices relationship with a Covered Entity.", "This allows the Covered Entity (provider) to use patient data with patient permission.", "It also may allow a Covered Entity to share information with a business associate.", "The patient data in a HIPAA relationship is owned by the provider.", "It may be difficult for a patient to gain access to their data and to share it with other providers outside the Covered Entity network.", "A relatively new model for storing patient data has been developed called a Personal Health Record (PHR).", "A PHR puts the patient in charge of their electronic health data, allowing them to retain ownership and share their health data with individuals and providers of their choosing.", "These PHR systems have typically been website repositories where patients input their PHR information.", "In one non-limiting embodiment, there is provided a system, method and apparatus that allows a patient to create, modify, own, access and/or enable third parties to access and/or modify the patient's own PHR record at a medical kiosk and/or at some other location or device (e.g., home PC, mobile device, entertainment center, or any other device that can access the phone, satellite and/or internet, etc.).", "The patient can optionally choose to share the PHR with a medical provider and/or commence a tele-medicine visit all in one convenient location.", "Medical devices with the medical kiosk and/or other location can send data directly to the PHR, storing it securely and optionally allowing immediate retrieval by an authorized provider during a visit.", "The remotely located medical provider can optionally have real time or near real time access to the PHR data, including medical device data from the medical kiosk and/or at some other location.", "The medical provider can optionally be allowed to update the patient's PHR data directly during a visit.", "The patient can have access to the updated PHR data from any phone, satellite, internet and/or intranet enabled device.", "The medical provider may also optionally be allowed by the patient to preserve a copy of the healthcare visit through integration with the medical provider's own EMR system.", "In accordance with one aspect of the present invention, the patient is able to keep their medical history information in a convenient, secure repository.", "The patient can share their data with various individuals, including medical providers.", "The patient inputs their healthcare information on a website, or directly into the medical kiosk or at some other location (e.g., home PC, mobile device, entertainment center, etc.).", "The creation of a PHR account and data at a remotely located, private, medical kiosk and/or some other location (e.g., home PC, mobile device, entertainment center, etc.)", "with medical devices where a tele-medicine visit can occur can be advantageous and convenient to a patient and/or medical provider.", "Another non-limiting advantage of the invention is the ability to create PHR data on a website, and later update and review that data, or simply access and share the PHR created on the website with a provider seen in the medical kiosk and/or some other location (e.g., home PC, mobile device, entertainment center, etc.).", "Another non-limiting advantage of the invention is the ability of a medical device at a remote medical station to send data immediately to the PHR datastore, and to be retrieved immediately by a remotely located provider.", "Another non-limiting advantage of the invention is the ability of a medical provider to immediately receive PHR data from a patient at a remotely located medical kiosk and/or some other location (e.g., home PC, mobile device, entertainment center, etc.)", "to conduct a real time or near real time healthcare consultation.", "Another, non-limiting advantage of the invention is the ability of a medical provider to gather PHR data from the medical kiosk and/or some other location (e.g., home PC, mobile device, entertainment center, etc.)", "consultation directly into the medical provider's own EMR system given a method to gain the express permission of the patient.", "Another non-limiting advantage of the invention is the ability of historical medical data, and/or medical data being created from a medical provider's EMR for a patient being seen in a medical kiosk and/or some other location (e.g., home PC, mobile device, entertainment center, etc.)", "then can be automatically transported to that patient's PHR during or after the visit.", "Another non-limiting advantage of the invention is the ability to enable patient access at a later time to healthcare data generated at the medical kiosk and/or some other location (e.g., home PC, mobile device, entertainment center, etc.)", "via a secure website.", "Another non-limiting advantage of the invention is the ability of a different medical provider, if given permission by the patient, to access the patient history created by one or more other medical providers without needing to contact those other medical providers.", "Another non-limiting advantage of the invention is the ability to create a PHR account at a remote medical kiosk location and/or some other location (e.g., home PC, mobile device, entertainment center, etc.)", "and use it immediately to consult with a medical provider.", "Another non-limiting advantage of the invention is the ability to create PHR data on a website and later use it at a remote medical kiosk and/or some other location (e.g., home PC, mobile device, entertainment center, etc.).", "Another non-limiting advantage of the invention is the ability for the patient to maintain ownership of their health information and share their healthcare data created at the medical kiosk and/or some other location (e.g., home PC, mobile device, entertainment center, etc.)", "with any medical provider or individual of their choosing.", "Another non-limiting advantage of the invention is the ability to have better continuity of care and speed of information sharing.", "In yet another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals there is provided a medical kit that includes one or more medical devices that can be used with a personal medical kiosk.", "In one non-limiting configuration of the medical kit, there is provided a container that has a base that includes a plurality of compartments for holding one or more medical devices.", "The one or more compartments can also contain other materials and/or devices (e.g., band-aid, bandage, gauze, tweezers, scissors, etc.).", "The container can be made of various types of materials (e.g., plastic, metal, etc.)", "The shape, size and configuration of the container are non-limiting.", "The container can be shaped and size to be portable so that it can be conveniently conveyed and/or used in a variety of locations.", "The lid of the container can include a compartment that is designed to removably hold a tablet computer, smart device, smart phone, IPad, or the like.", "As can be appreciated, the lid of the container can incorporate a permanent display.", "If a tablet computer, IPad, or the like is used with the container, the tablet computer, IPad, or the like is used as the display for the personal medical kiosk.", "The camera on the tablet computer, IPad, or the like is used to convey images to the remotely located medical provider.", "Software can be loaded into the tablet computer, IPad, or the like to interface with the remotely located medical provider, and/or the container can include hardware and/or software that is used with the tablet computer, IPad, or the like.", "The one or more medical devices can be wirelessly connected or directly to the hardware and/or software in the container, and/or be wirelessly connected or directly to the tablet computer, IPad, or the like.", "The container can include a lock or other security arrangement to inhibit or prevent unauthorized use of the container.", "The container can include one or more connectors (e.g., USB, Bluetooth, Wi-Fi, etc.).", "It is one non-limiting object of the invention to provide tele-medicine services that are convenient to a user.", "It is another and/or alternative one non-limiting object of the invention to provide tele-medicine services that are cost effective to a user.", "It is still another and/or alternative one non-limiting object of the invention to provide tele-medicine services that can be provided to a user via a medical kiosk.", "It is yet another and/or alternative one non-limiting object of the invention to provide tele-medicine services that can be provided to a user via a modular medical kiosk.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that is easy to assemble and disassemble.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes an easy and convenient registration system and payment system.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that provides privacy to a user when obtaining medical services.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that is sized and shaped to accommodate disabled or handicapped users.", "It is still yet another and/or alternative one non-limiting object of the invention is to provide a medical kiosk and method for using a medical kiosk that includes medical instruments that can be used by a user when obtaining medical services.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes video conferencing capabilities between a user and a medical provider.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that provides the option to play back one or more portions of the video conference session to the user after the video conference between the user and medical provider has been completed.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes an attendant station, digital signage, and/or a registration station on the exterior of the medical kiosk.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Screen and/or Patient Screen in the interior of the medical kiosk.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes one or more medical device cabinets on the interior of the medical kiosk.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes the use of a Patient Appointment or Registration Application, Attendant Application, Patient Appointment or Registration Application, Provider Application, Administrator Application, Patient Portal and/or Provider Portal.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Patient Appointment or Registration Application that enables patients to schedule an appointment at a medical kiosk.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes Patient Appointment or Registration Application that enables a patient to enter insurance information and/or to make a payment and/or copay for the medical visit in the kiosk.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes Patient Registration System that enables a patient to check-in for a preexisting appointment.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Patient Registration System that enables a patient to identify the patient's symptoms, medications, allergies, and/or medical conditions.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes registration and/or check-in system that enables a patient to request assistance from a medical attendant.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes an Attendant Application that enables a medical attendant to monitor past, present and/or future appointments for the medical kiosk.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes an Attendant Application that enables a medical attendant to monitor the status of a current visit in the medical kiosk.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes an Attendant Application that enables a medical attendant to cancel and/or reschedule an appointment to a medical kiosk.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes an Attendant Application that informs that medical attendant that the patient requires assistance.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes an Attendant Application that enables the medical attendant to keep track of the clean-up of the medical kiosk.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that enables the medical assistant to activate an automated sanitation and/or cleaning system of the medical kiosk.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes an Attendant Application that enables a medical assistant to validate the insurance and/or ID of a patient.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Patient Appointment or Registration Application that helps the patient capture vitals and/or enter the vitals information during the visit.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Patient Appointment or Registration Application that enables the patient to request assistance from the medical attendant.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Patient Appointment or Registration Application that can assist the patient during the consultation with the medical provider.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Patient Appointment or Registration Application that enables a patient to take a survey regarding the consultation with the medical provider and/or the use of the medical kiosk.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that assists the medical provider in providing medical services to the patient in the medical kiosk.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that provides information to the medical provider regarding past, current and future appointment that have been scheduled with the medical provider.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that enables the medical provider to view personal information that the patient has entered regarding the medical visit.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that enables the medical provider to view vitals that have been collected on the patient.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that enables the medical provider to request that the medical attendant assist the patient in the medical kiosk.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that enables the medical provider to control the use and/or access of one or more medical devices in the medical kiosk.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that enables a medical provider to create a visit summary of the patient in the medical kiosk.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that enables the medical provider to update personal information, medical history information and/or symptom information about the patient.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that enables a medical provider to select and/or enter a diagnosis for a patient.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that enables the medical provider to enter notes about a patient and/or create a treatment plan for a patient.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that enable a medical provider to view information about past visits by a patient.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a mobile application and/or an on-line application that enables a patient to 1) conveniently locate an available medical kiosk, 2) schedule an appointment (e.g., date and/or time), 3) pre-register symptoms and/or reasons for visit, 4) set and/or cancel an appointment, 5) receive reminders and/or updates regarding appoints, 6) obtain information about medical kiosk availability, 7) obtain information about certain medical provider availability, 8) obtain information about the available medical provider (e.g., name, specialty, etc.", "), 9) enable the selection of a certain medical provider and/or medical provider in a certain field of medicine, 10) obtain map information, address information and/or hours of operation information regarding selected medical kiosk, 11) locate closest kiosk and/or kiosk availability for a certain medical provider and/or medical provider in a certain field of medicine, 12) presubmit and/or preclear medical insurance, 13) submit payment information, 14) receive information on payment status, 15) receive information in insurance coverage, 16) receive appointment reminders and/or updates, and/or 17) receive medication reminders, and the like.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a scale in the floor of the medical kiosk.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medication adherence application that allows a user/patient to 1) speak to a pharmacist, 2) change the patient's medications alerts, 3) learn about certain types of medical conditions, 4) check medication orders status, 5) check medication delivery status, 6) refill a prescriptions, 7) transfer prescriptions to a another location, 8) obtain information about recommended medication dosages, 9) obtain information about recommended times to take medications, 10) obtain information about recommended frequency for taking medications, 11) obtain information about medications, 12) obtain information about generic brands available for medications, 13) request an appointment to speak with a medical provider, 14) enter information regarding compliance information regarding medication usage by patient, and/or 15) receive compliance reports for patients regarding medication usage.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medication adherence application that 1) sends reminders for user/patients to take their medications, 2) monitors a user's/patient's adherence to taking their medications and/or distributes progress reports to the patient, and/or 3) automatically enrolls a patient in an electronic prescriptions network which can optionally send a patient's prescriptions to their choice of pharmacy.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes one or more headphone jacks in the medical kiosk.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medical kiosk having HD components and an industrial strength design.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medical kiosk having a modular configuration and/or a configuration that enables the medical kiosk to be brought in to or removed from locations having a standard sized doorway.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medical kiosk having a check-in registration system positioned on the exterior of the medical kiosk.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medical kiosk having one or more medical device cabinets located in the interior of the medical kiosk.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medical kiosk having digital signage on the interior and/or exterior of the medical kiosk.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medical kiosk having a built-in sanitation system.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that allows patients to 1) choose between name brand and generic drugs, 2) choose the supply quantity for the prescription (i.e., 30-day supply, 60-day supply, 90-day supply, etc.", "), 3) choose between picking the prescription up at the pharmacy of their choice or mail delivery of the prescription, 4) enter medical insurance for partial or full payment of the prescription, 5) enter a credit or debit card information to pay for the prescription, 6) enter information for mail delivery of the prescription, 7) enter information to provide automatic reminders to patient regarding refilled and/or follow-up medical visits, 8) enter information to enable patient to be notified when prescription has been mailed and/or is ready to be picked-up at the pharmacy; however, this is not required, 9) obtain a printout and/or electronic version of the prescription written by the medical provider, and/or 10) receive information about the issued prescription (e.g., prescribed use, side effects, etc.)", "in printout and/or electronic form.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medical kiosk having a movable front interior wall panel to enable access to components that are positioned behind the front interior wall of the medical kiosk.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a scheduling system for scheduling a patient for a tele-medicine visit into a remotely located healthcare kiosk.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a scheduling system that can streamline, speed up, and/or reduce wasted time for scheduling tele-medicine patient-provider visits in multitude of remotely located (or home/mobile based) medical kiosks by automating aspects that assist medical providers in managing waiting queues of patients.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a scheduling system that can assist patients with information about expected wait times.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a scheduling system that can use wait queuing and/or reservation scheduling for a medical kiosk.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medical device panel and associated software to aggregate a plurality of medical devices into a single medical device panel and software system.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that uses a standalone FDA- or other type of agency-approvable medical device control panel with a configurable user interface to adapt and harmonize with related software solutions, to interface directly with multiple third-party manufacturer's device integration APIs, and/or to reside as a completely separate module within a larger telehealth software solution.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes medical device control panel software that is a separate and standalone solution that can be seamlessly incorporated into a larger software solution.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medical device control panel software to aggregate multiple medical device APIs into a single medical device control software (with modular aspects for various devices) with configurable user interface, to keep all aspects of device control separate from any other software, limiting the FDA or other agency's approval process to this single piece of software.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a development kit for device manufacturers to create medical device APIs within the architecture of this solution so that configurable medical device controls can easily be shared with various system integrators and the FDA or other agency's approval remains with the original device manufacturer.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes the ability of a medical provider to optionally remotely control a device through the medical device control panel using an FDA cleared method.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that allows the device data from the control panel to be sent directly to an EMR and/or PHR.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a personal medical kiosk that can be used with a plurality of medical devices that can be contained in a common housing.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a multipurpose home and/or mobile medical device that includes some combination or subset of at least two of the following devices: stethoscope, otoscope, dermascope, thermometer, blood pressure, pulse oximeter, ECG, spirometer, and glucometer.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that enables a patient to create, modify, own, access and/or enable third parties to access and/or modify the patient's own PHR record at a medical kiosk and/or at some other location or device (e.g., home PC, mobile device, entertainment center, or any other device that can access the phone, satellite and/or internet, etc.).", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that enables a medical provider to be allowed to update the patient's PHR data directly during a visit.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for a personal medical kiosk that includes the use of a medical kit that includes one or more medical devices that can be used with a personal medical kiosk.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a personal medical kiosk that includes the use of a medical kit that includes a plurality of compartments for holding one or more medical devices using a personal medical kiosk that includes the use of a medical kit and optionally includes one or more compartments that can contain other materials and/or devices (e.g., band-aid, bandage, gauze, tweezers, scissors, etc.).", "These and other objects and advantages will become apparent to those skilled in the art upon reading and following the description taken together with the accompanying drawings." ], [ "The present invention is a continuation-in-part of Ser.", "No.", "13/760,345 filed Feb. 6, 2013, which in turn is continuation-in-part of U.S. Ser.", "No.", "13/314,473 filed Dec. 8, 2011, which in turn claims priority on U.S. Patent Application Ser.", "Nos.", "61/469,851 filed Mar.", "31, 2011 and 61/541,719 filed Sep. 30, 2011, which are both incorporated herein by reference.", "The present invention is a continuation-in-part of Ser.", "No.", "13/760,345 filed Feb. 6, 2013, which in turn is continuation-in-part of U.S. Ser.", "No.", "13/314,473 filed Dec. 8, 2011, which in turn is a continuation-in-part of United States Design patent application Ser.", "No.", "29/403,857 filed Oct. 12, 2011 (now U.S. Design No.", "D694,909; issued Dec. 3, 2013), which are both incorporated herein by reference.", "The present invention claims priority on U.S. Patent Application Ser.", "Nos.", "61/847,741 filed Jul.", "18, 2013; 61/847,745 filed Jul.", "18, 2013; 61/847,753 filed Jul.", "18, 2013; 61/847,760 filed Jul.", "18, 2013, and 62/016,193 filed Jun.", "24, 2014, which are all incorporated herein by reference.", "The present invention is directed to medical services, more particularly to a method and device for providing medical services to individuals, even more particularly to a method and device for providing medical services to individuals at locations that traditionally have not provided medical services, and still even more particularly to a medical kiosk and method for using a medical kiosk for providing medical services to individuals at locations that are remote from a medical provider.", "BACKGROUND OF THE INVENTION Medical services are traditionally provided to individuals at a doctor's office or medical facility.", "Typically, an individual contacts his/her medical provider when the individual requires some type of medical assistance.", "The medical provider then sets an appointment time and date for the individual to see the medical provider.", "Many times, the time and date of the appointment are inconvenient for the individual.", "Furthermore, the individual seeking medical assistance may desire or need more immediate medical assistance and cannot wait for the time and date set by the medical provider.", "In such situations, the individual goes to the emergency room of a hospital or some type of medical clinic (e.g., Minute Clinic, Take Care Clinic, Urgent Care Clinic, etc.", "), assuming that such clinics are available or convenient to visit.", "In other situations, especially in smaller towns and rural areas, a medical facility may be located many miles away thus making a visit to such a facility very inconvenient.", "As such, many individuals who should seek medical care decide to not seek the advice of medical personnel due to the inconvenience of having to travel large distances to a medical facility.", "The costs associated with visiting a medical provider can be costly depending on the type of insurance, if any, the individual carries.", "When an individual visits the emergency room of a hospital, the medical costs can be substantially higher and insurance coverage may be limited to various types of visits.", "Insurance coverage and the cost of the visit may also vary at various clinics.", "In many communities, clinics are not readily available, thus the individual must either visit the medical provider or go to the hospital.", "Various pharmacy and drug stores have begun offering medical services on their premises.", "These locations generally offer flu shots and very basic medical services, and are typically provided by a nurse practitioner, not a doctor.", "As such, only very limited types of medical services are offered at such locations.", "Also, these locations are not offered in a private environment.", "Generally, the services are provided in a side corridor or partitioned location in the facility.", "In view of the current state of the medical services, there is a need for providing medical services in a more convenient, desirable, timely and cost effective manner.", "SUMMARY OF THE INVENTION The present invention is directed to a method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals in a convenient, desirable, timely and cost effective manner.", "The novel medical apparatus of the present invention and the novel method for providing medical services, diagnoses, health advice, and/or wellness advice addresses the current deficiencies that exist for providing medical services to individuals.", "In one non-limiting aspect of the invention, there is provided a method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals that includes a remote medical service arrangement wherein a patient can receive various types of medical advice and services remotely from one or more medical providers (e.g., doctor, nurse practitioner, nurse, psychologist, psychiatrist, optometrist, physician assistant, pharmacist, health coach, dietitian, medical assistant, etc.).", "Traditionally, a patient was required to go to a medical facility (e.g., hospital, medical clinic, doctor's office, etc.)", "to personally meet with and be diagnosed by the medical provider.", "The present invention is directed to a method wherein medical services, diagnoses, health advice, and/or wellness advice can be dispensed by a medical provider at a location that is remote from the patient.", "The present invention can be used to provide services in one or more different medical specialties (e.g., Allergology; Andrology; Anesthesia; Angiology; Athletic training; Aviation medicine; Cardiology; Dentistry; Dermatology; Disaster medicine; Emergency medicine; Endocrinology; Family medicine; Gastroenterology; General practice; Medical genetics; Geriatrics; Gerontology; Gynaecology; Hematology; Hepatology; Immunology; Infectious diseases; Intensive care medicine; Internal medicine; Military medicine; Nephrology; Neurology; Nuclear medicine; Obstetrics; Oncology; Ophthalmology; Oral and maxillofacial surgery; Orthopedics; Otolaryngology; Paleopathology; Palliative medicine; Pathology; Pediatrics; Podiatry; Psychiatric specialties; Psychiatry; Pulmonology; Radiology; Rehabilitation medicine; Rheumatology; Serology; Sexual health; Sleep medicine; Space medicine; Sports medicine; Surgery; Toxicology; Transplantation medicine; Tropical medicine; Urology; Wilderness medical emergencies; and/or Wilderness medicine).", "The method and device of the present invention can be used to provide initial screening, treatment, and/or follow-up treatment for a patient.", "The method and device of the present invention can be used in many situations as an alternative for a patient visiting a medical facility or a doctor's office.", "However, it can be appreciated that the device of the present invention could be located in a lobby or special region of a doctor's office or medical facility.", "In one non-limiting arrangement of the present invention, there is provided an audio and/or video link between one or more medical providers located at one or more locations (e.g., medical provider's office, medical provider's home, hospital, etc.)", "and the patient is located at some other location (e.g., shopping mall, shopping center, drug store, grocery store, department store, warehouse store, discount retailer, discount department store, truck trailer, mobile office, mobile home, office space location, home, car, train, boat, cruise line, friend's home, etc.)", "that is remote from the one or more medical providers.", "In essence, the patient can be at any location in which the patient can obtain telephone, satellite, Wi-Fi and/or internet access.", "The novel method of the present invention for providing medical services, diagnoses, health advice, and/or wellness advice enables a medical provider to provide medical services, diagnoses, health advice, and/or wellness advice to patients without the patient having to physically visit the medical provider and/or having to go to the medical provider's office or place of work.", "As can be appreciated, the audio and/or video link that is used by the medical provider can enable the medical provider to provide medical services, diagnoses, health advice, and/or wellness advice at a single remote location or a plurality of remote locations.", "When the audio and/or video link enables the medical provider to provide medical services, diagnoses, health advice, and/or wellness advice to a plurality of remote locations, a single medical provider and/or a plurality of medical providers can be used to provide medical services, diagnoses, health advice, and/or wellness advice to patients that are located at a variety of different remote locations.", "When a plurality of medical providers is used, the medical providers can be located at the same or different locations.", "As can be appreciated, the novel method for providing medical services allows for more flexibility for a patient to obtain medical services, diagnoses, health advice, and/or wellness advice.", "The site at which the patient obtains the medical services, diagnoses, health advice, and/or wellness advice via the method and device of the present invention can be located in a) non-traditional locations that are more convenient to a patient (e.g., shopping mall, public park, department store, retail store, grocery store, museum, office building, business office, business facility, big box stores, government base or facility, drug stores, boat, airplane, train, home, friend's home, car, patient's workplace, etc.", "), and/or b) traditional locations (e.g., doctor's office, hospital, urgent care facility, etc.)", "so as to provide easier and/or more convenient access to such medical services, diagnoses, health advice, and/or wellness advice.", "The geographic location for the device of the present invention can be in a single residence, a single business building, a single neighborhood, multiple neighborhoods, a single town or city, multiple towns or cities, a single state or province, multiple states or provinces, a single country, multiple countries, space, domestic and/or international waterways, etc.", "The novel method can also be used to provide medical services, diagnoses, health advice, and/or wellness advice at standard times (e.g., 9 am-5 pm Monday through Friday, etc.)", "and/or non-standard times (e.g., early morning hours, evening hours, weekend hours, holiday hours, etc.)", "to enable a patient to obtain medical services, diagnoses, health advice, and/or wellness advice at times that are more convenient and timely to the patient.", "In another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be used to provide a variety of different medical services, diagnoses, health advice, and/or wellness advice.", "Non-limiting examples of such medical services, diagnoses, health advise, wellness advise and/or medical conditions that can be identified, treated and/or addressed include, but are not limited to, acid reflux; hypertension management; allergies; Athlete's Foot; acne; mental health counseling; wellness counseling; asthma; cold sores; vaccinations; arthritis; bronchitis; impetigo; wellness coaching; weight loss; eating disorders; bladder infections; insect stings; allergic reactions; rashes; hemorrhoids; minor burns; health risk management; migraine headaches; common colds; virus infections; bacterial infections; minor skin infections; chronic disease management; coughs; Poison Oak/Ivy; diarrhea; rashes; diabetes; ringworm; lice; ear infections; sties; flu; fever; gout; headache (minor); pink eye; sinus infections; sore throat; ear infections; cramps; STDs; strep throat; throat infections; feeding problems for newborns; vomiting; teething; gastrointestinal problems; anxiety; depression, formula advice for newborns; concussion; head injuries; bone fractures; sprains; hair loss; alopecia; eye infections; urinary tract infections; constipation; appendicitis; pharyngitis; medication therapy management; acid reflux disease; acne; alcohol abuse; allergies; antisocial personality disorder; attention deficit disorder; altitude sickness; Alzheimer's Disease; andropause; anger management; anorexia nervosa; arthritis; Aspergers Syndrome; asthma; autism; back pain; bad breath (halitosis); baldness; bedwetting; bipolar disorder; bladder cancer; body dysmorphic disorder; bone cancer; brain cancer; breast cancer; brain tumors; brain injury; bronchitis; burns; bursitis; cancer; canker sores; Carpal Tunnel Syndrome; celiac disease; cervical cancer; cholesterol; chronic obstructive pulmonary disease; colon cancer; congestive heart failure; cradle cap; Crohn's Disease; dandruff; deep vein thrombosis; dehydration; depression; diabetes; diaper rash; disabilities; diverticulitis; Down Syndrome; drug abuse; smoking cessation; dysfunctional uterine bleeding; dyslexia; ear infections; ear problems; eating disorders; eczema; endometriosis; enlarged prostate; epilepsy; erectile dysfunction; eye problems; fibromyalgia; fracture; gallbladder disease; gallstones; generalized anxiety disorder; genital herpes; genital warts; glomerulonephritis; gonorrhea; gout; gum diseases; gynecomastia; head lice; headache; hearing loss; heart attacks; heart disease; heartburn; heat stroke; heel pain; hemorrhage; hemorrhoids; hepatitis; herniated discs; hiatal hernia; HIV/AIDS; hives; hyperglycemia; hyperkalemia; hypertension; hyperthyroidism; hypothyroidism; infectious diseases; infectious mononucleosis; influenza; infertility; insulin dependent diabetes mellitus; iron deficiency anemia; irritable bowel syndrome; irritable bowel syndrome; itching; joint pain; juvenile diabetes; juvenile rheumatoid arthritis; kidney diseases; kidney stones; leukemia; liver cancer; lung cancer; Mad Cow Disease; malaria; medication management; melena; memory loss; menopause; mesothelioma; migraine; miscarriages; mucus in stool; multiple personality disorder; multiple sclerosis; muscle cramps; muscle fatigue; muscle pain; nail biting; narcissistic personality disorder; neck pain; obesity; obsessive compulsive disorder; osteoarthritis; osteomyelitis; osteoporosis; ovarian cancer; ovarian cyst; pain; pain management; panic attack; Parkinson's Disease; peripheral artery disease; personality disorders; pervasive developmental disorder; Peyronie's Disease; phobias; pink eye; polio; pneumonia; post nasal drip; post-traumatic stress disorder; premature baby; premenstrual syndrome; prostate cancer; psoriasis; reactive attachment disorder; renal failure; restless legs syndrome; rheumatoid arthritis; rheumatic fever; ringworm; rosacea; rotator cuff; scabies; scars; sciatica; schizophrenia; sexually-transmitted disease; sinus infections; skin cancer; skin rash; sleep apnea; sleep disorders; smallpox; snoring; social anxiety; staph infection; stomach cancer; strep throat; Sudden Infant Death Syndrome; sunburn; syphilis; systemic lupus erythematosus; tennis elbow; termination of pregnancy; testicular cancer; tooth decay; tuberculosis; ulcers; urinary tract infection; varicose veins; vertigo; warts; Williams Syndrome; yeast infection; Yellow Fever, etc.", "As can be appreciated, other or additional types of medical services and/or health care services can be provided.", "The medical services and/or health care services that can be provided can include, but are not limited to, 1) providing advice and/or recommendations about a medical condition, 2) diagnosing and/or treating a medical condition, 3) providing referral services for a medical condition, 4) prescribing medicine for a medical condition, 5) periodically monitoring a medical condition, 6) providing follow-up checks for a medical condition, 7) providing routine check-up services, 8) providing advice, counseling, and/or recommendations about medical and/or health matters, 9) providing a course of treatment for a medical condition, 8) providing health counseling, 10) providing health information, 12) providing wellness counseling, and/or 13) providing wellness information.", "As can be appreciated, other or additional services can be provided to the patient.", "In essence, any type of medical condition, medical concern, health concern, wellness concern, etc.", "can be addressed in whole or in part by the novel method and apparatus for providing medical services of the present invention.", "Hereinafter, these services will be collectively referred to as medical services.", "As can be appreciated, the type of services provided to a patient will depend on the specific medical condition, medical concern or need, wellness concern or need, and/or health concern or need of the patient.", "In many instances, the medical provider will be able to diagnose, address, advise, consult and/or treat the specific medical condition or need, medical concern or need, wellness concern or need, health concern or need, etc.", "of the patient.", "In some instances, the specific medical condition or need, medical concern or need, wellness concern or need, health concern or need, etc.", "of the patient may be too complicated and/or too complex to address via an audio and/or video link; thus, the medical provider in such situations may need to refer the patient to a hospital, a doctor's office, counselor, psychiatrist/psychologist, medical specialist, health professional, dietician, rehabilitation facility, or a traditional medical clinic for further counseling, treatment and/or diagnosis, or some other location or professional that can address the patient's needs and/or requirements.", "In still another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of a medical kiosk to enable the patient to conveniently communicate with one or more medical providers.", "One or more medical kiosks can be used in the present invention.", "Generally, a plurality of medical kiosks which are located at one or more locations are used in the method of the present invention; however, it can be appreciated that a single medical kiosk can be used in accordance with the present invention.", "Typically, one or more medical providers provide services to one or more medical kiosks.", "The size, shape, configuration and look of the medical kiosk are non-limiting.", "The medical kiosk, when in the form of a personal medical kiosk, may merely be in the form of a tablet, laptop, smart phone, etc., that is being used in any location that the patient desires.", "The medical kiosk, when in the form of a free standing structure, can be configured in a variety of ways.", "For example, the medical kiosk can take the form of a room, partition area, etc.", "that includes laptop computer, desktop computer, tablet, etc.", "Alternatively, the medical kiosk, when in the form of a free-standing structure, can include an enclosure that is designed to enable a patient to enter the enclosure and to communicate with the medical provider.", "In one non-limiting embodiment of the invention, the medical kiosk provides a private or semi-private environment for a patient to communicate with one or more medical providers that are located remotely from the medical kiosk.", "The medical kiosk can include an enclosure that is designed to enable a patient to enter the enclosure and to communicate with the medical provider in a private or semi-private manner while in the enclosure of the medical kiosk.", "The size, shape and configuration of the enclosure of the medical kiosk are non-limiting.", "In another and/or alternative non-limiting arrangement, the medical kiosk includes one or more walls that form all or a portion of the sides of the enclosure of the medical kiosk.", "The enclosure may include one or more doors or entry points to enable a patient to enter and/or exit the enclosure.", "In another and/or alternative non-limiting arrangement, the medical kiosk typically includes a floor and/or a ceiling.", "The ceiling, when included, can include a portion that is partially or fully transparent; however, this is not required.", "In another and/or alternative non-limiting arrangement, the medical kiosk can have a modular configuration to enable the parts of the medical kiosk to be set up in various configurations to enable the medical kiosk to be used in various types of spaces and/or to be set up in various types of configurations.", "The medical kiosk can be formed of any number of materials (e.g., plastic, foam, metal, wood, composite materials, fiber board, etc.).", "The one or more walls of the medical kiosk can be designed to be interchangeable to enable the door, when used, to be positioned on various locations on the medical kiosk; however, this is not required.", "The medical kiosk can include a floor and/or ceiling to provide for increased privacy for the patient when the patient is inside the room, cavity or enclosure of the medical kiosk; however, this is not required.", "The medical kiosk can include one or more tables, ledges, benches, and/or seats in the interior and/or exterior of the medical kiosk; however, this is not required.", "Such table, ledge, bench, and/or seat, when used, can be designed to be connected in multiple locations on the exterior and/or interior of the medical kiosk; however, this is not required.", "The modular configuration of the medical kiosk can be such that it can be easily assembled and/or disassembled so that the medical kiosk can be easily brought into a location and easily set up, and/or be easily removed from a location; however, this is not required.", "In yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of a medical kiosk in the form of a personal medical kiosk to enable the patient to conveniently communicate with one or more medical providers.", "The size, shape, configuration and look of the personal medical kiosk are non-limiting.", "In one non-limiting embodiment of the invention, the medical kiosk, when in the form of a personal medical kiosk, includes a personal computer interface (e.g., laptop computer, desktop computer, tablet, smart phone, notepads, home PC, smart TVs, and/or entertainment console [e.g., Xbox systems, PS3, PS4, Apple TV, Amazon Fire TV, etc.]", "etc.)", "that can be used by a user to create a video connection with a remotely-located medical provider.", "The personal medical kiosk also includes an interface that enables the personal computer interface to communicate with one or more medical devices that are to be used by the patient.", "In one non-limiting arrangement, the personal medical kiosk is designed to enable a patient to communicate with the medical provider in a private or semi-private manner (e.g., patient's home, car, friend's home, boat, hotel, etc.).", "In still yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of a medical kiosk that includes one or more data input terminals; however, this is not required.", "The one or more data input terminals can be located on one or more locations on the exterior of the medical kiosk; however, this is not required.", "Alternatively or additionally, the one or more data input terminals can be located on one or more locations in the interior or enclosure of the medical kiosk; however, this is not required.", "Alternatively or additionally, the one or more data input terminals can be in the form of a laptop computer, desktop computer, tablet, smart phone, etc.", "The one or more data input terminals can include a video display to display information regarding identification and/or data entry, a camera and/or video camera used to collect information for identification and/or data entry, a keypad or keyboard for identification and/or data entry, a touch screen for identification and/or data entry, microphone and voice recognition software for identification and/or data entry, fingerprint scanner for identification and/or data entry, retina scanner for identification and/or data entry, and/or face and/or body scanners for identification and/or data entry.", "As can be appreciated, other or additional devices can be included on the medical kiosk to display and/or obtain information regarding identification and/or data entry.", "The medical kiosk can be used by the patient to enter/convey basic information about the patient.", "Such information includes, but is not limited to, a) patient name, b) patient address, c) patient contact information (e.g., home address, work address, phone number, email address, pager number, work number, etc.", "), d) patient age, e) patient sex, f) patient height, g) patient weight, h) patient medical history, i) current medicines used by patient, j) reason(s) for visit by patient, k) patient current symptoms, l) patient insurance information, m) patient payment information, n) patient's current doctor, o) guardian or patent information, p) next of kin information, q) desired medical provider for visit, r) allergy information, s) information about a prior visit, t) medical records information, and/or u) pharmacy information.", "As can be appreciated, other or additional information can be inputted/conveyed by the patient.", "In another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medial kiosk that can be designed to provide information to the patient prior to and/or during the inputting/conveying of information by the patient to the medical kiosk.", "In one non-limiting embodiment of the invention, the medical kiosk can include audio and/or visual instructions and/or displays used to provide a) information about the medical kiosk, b) how to use the medial kiosk, c) how to properly input/convey information to the medical kiosk, d) provide instructions and/or interactions with the patient during the inputting/conveying of information by the patient to the medical kiosk, e) the wait time for the patient's use of the medical kiosk, f) a list of patients waiting to use the medical kiosk, g) available medical providers, h) types of medical issues that can be addressed by use of the medical kiosk, i) insurance providers that can be used to partially or fully pay for a visit in the medical kiosk, j) payment options for use of the medical kiosk, k) information regarding when the medical kiosk is available in the future, and/or l) information regarding whether the medical kiosk is in use or is available.", "In another and/or alternative non-limiting embodiment of the invention, the medical kiosk can include light, sound indicators, and/or digital displays to provide information regarding whether the medical kiosk is in use or is available; however, this is not required.", "In still another and/or alternative non-limiting embodiment of the invention, the medical kiosk can include a notification system to a patient that the medical kiosk is available or will soon be available; however, this is not required.", "Such a notification can be sent via email, text, phone, pager, internet, digital display, etc.", "Such notification system can be useful when the medical kiosk is not currently available to the patient.", "The patient can input the information into the medical kiosk and then go home, run other errands, etc., and then be later notified when the medical kiosk is available or will soon be available.", "The medical kiosk and/or notification system can also be used to inform the patient when and/or where other medical kiosks are available; however, this is not required.", "This service, when available, can be used to inform the patient that a nearby medical kiosk has a shorter wait period or is currently available, thus providing the patient with the option of traveling to another available medical kiosk instead of waiting for the current medical kiosk to become available; however, this is not required.", "This service, when available, can also be used to inform the patient when a prescription is ready for pickup and/or for conveying prescription information to the patient; however, this is not required.", "This service, when available, can also be used to inform the patient when a follow-up visit is due and/or scheduled; however, this is not required.", "As can be appreciated, the notification system can be used for other or additional services.", "In still another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a scheduling system for use of the medical kiosk.", "The scheduling system allows a patient to schedule an appointment with a medical provider when the patient uses the medical kiosk.", "The scheduling system can be used to 1) enable a patient to select a particular medical provider, 2) make an appointment on a medical kiosk for a particular time and place, 3) enable a patient to select a medical provider or type of medical provider based on the particular need of the patient (e.g., select a medical provider that specializes in dermatology to address a rash issue on the patient, select a medical provider that specializes in orthopedics to address a sports injury to the knee, etc.", "), 4) locate available locations of medical kiosks, 5) enable a patient to enter basic information about the patient, 6) check a past, current or future appointment of the patient regarding use of the medical kiosk, 7) enter a partial or full payment for use of the medical kiosk, 8) enter medical insurance information, etc.", "The scheduling system can be designed to be accessed by a patient on a data entry device on a medical kiosk, via a computer or phone or smart device, and/or by phone.", "The scheduling system can optionally be designed to enable a patient to request assistance if there a question regarding the use of the scheduling system.", "In yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include one of more software applications (e.g., Patient Registration Application, Attendant Application, Patient Appointment or Registration Application, Medical Provider Application, Administrator Application, Patient Portal, Provider Portal, etc.", "); however, this is not required.", "For example, the Patient Appointment or Registration Application can include the screens the patient navigates through during the patient registration process; however, this is not required.", "These screens can optionally appear on the registration station of the exterior of the medical kiosk.", "The Attendant Application can include screens through which the medical attendant, when used, navigates during the patient appointment; however, this is not required.", "These screens can optionally appear on a laptop, computer screen, tablet, smart phone, etc.", "located with the medical attendant and/or at or near the attendant desk on the exterior of the medical kiosk; however, this is not required.", "The Patient Appointment or Registration Application can include screens through which the patient navigates during the patient consultation; however, this is not required.", "These screens can optionally appear on the medical provider screen and/or patient screen in the interior of the medical kiosk.", "The Provider Application can include the screens through which the medical provider navigates during the patient appointment; however, this is not required.", "These screens can optionally appear on the medical provider's computer, laptop, tablet, smart phone, etc.", "at his/her remote location.", "As can be appreciated, other or additional software and/or hardware application can be used with the medical kiosk of the present invention.", "The Patient Appointment or Registration Application can allow the patient to select a language to be displayed (e.g., English, Spanish, German, French, Chinese, Japanese, etc.", "); however, this is not required.", "In another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of a Patient Appointment or Registration Application; however, this is not required.", "The Patient Appointment or Registration Application can include one or more navigational buttons (e.g., Back, Next, Cancel, Request Assistance, etc.)", "for use by the patient during the registration process; however, this is not required).", "For example, the Back button can be designed to allow the patient to return to the previous screen, the Next button can be designed to allow the patient to proceed to the next screen, the Cancel button can be designed to allow the patient to cancel a process and return to the beginning of the process (e.g., patient receives a pop-up box asking them if they are sure they want to cancel and return to the beginning of the process.", "They may choose “Yes” or “No”.", "“Yes” returns them to the beginning of the process.", "“No” returns them to the screen they were on when they hit the Cancel button), and the Request Assistance button can be designed to allow the patient to request assistance from the Attendant (e.g., the patient can receive a pop-up box notifying them that the attendant will be with them in a moment and the attendant also receive a notice that the patient requires assistance.", "The notice provided to the attendant can optionally be color coded and/or generate a certain sound to indicate the source and/or seriousness of the request by a patient and/or medical provider, etc.).", "The Patient Appointment or Registration Application can include a process through which the patient identifies themselves as a new and/or returning patient and either schedules an appointment at one or more medical kiosks or registers for an existing appointment at one or more medical kiosks.", "The medical kiosk can optionally be staffed by a medical assistant or attendant at all times.", "During the patient registration process, the medical assistant or attendant responsibilities, when used, can include welcoming the patient, offering assistance, validating patient identification, initiating/finalizing the patient consultation, and/or completing the sanitization process.", "As can be appreciated, the medical assistant or attendant can have other or additional responsibilities (e.g., check operation of medical kiosk, report a malfunction of a medical kiosk, monitor appointment status of medical kiosk, assist the patient in the medical kiosk, reload software, etc.).", "As can be appreciated, the personal medical kiosk generally does not include a medical assistant and/or attendant.", "The Patient Appointment or Registration Application can optionally be designed to enable a patient to register and schedule appointments through one or more methods (e.g., on-line registration, calling a registration location, visiting a medical kiosk, etc.).", "During the patient registration process, the Patient Appointment or Registration Application can include scheduling software that provides a scheduling system for a patient to register with one or more medical kiosks.", "The scheduling system can be designed to be accessed by a patient on a data entry device on a medical kiosk, via a computer, satellite, phone, smart TV, entertainment systems, or any other device that can access a phone signal, satellite signal and/or the internet.", "The patient registration system can be designed to 1) schedule a new appointment for a patient, 2) schedule an appointment for a returning patient, and/or 3) welcome a patient that has already scheduled an appointment.", "In one non-limiting arrangement, the patient registration system generally asks if the patient is a returning patient, a new patient or if the patient requires assistance.", "The patient registration system generally provides the patient with a privacy policy associated with the use of the medical kiosk; however, this is not required.", "When a privacy policy is presented to the patient, the patient generally must acknowledge or accept the privacy policy before the patient can proceed further with the registration process; however, this is not required.", "The patient registration system generally provides the patient with terms of service policy associated with the use of the medical kiosk; however, this is not required.", "When the terms of service policy is presented to the patient, the patient generally must acknowledge or accept the terms of service policy before the patient can proceed further with the registration process; however, this is not required.", "The patient registration system generally asks why the patient is using the patient registration system (e.g., Medical kiosk tour, Medical kiosk demo, Medical kiosk payment demo, check-in for a medical visit, etc.).", "The patient registration system generally asks the patient to enter a password, phone number, pin number, name, email address, address, date of birth, sex, or the like to identify the patient; however, this is not required.", "The patient registration system generally asks the patient to verify if the patient is at least a certain age (e.g., at least two years old, etc.)", "before medical services can be provided by the medical kiosk; however, this is not required.", "The patient registration system generally asks the patient to identify one or more symptoms (e.g., body aches, chest congestion, cough, earache or pain, eye itching or swelling, fatigue, fever, headache, nasal congestion, nausea, pink eye, shortness of breath, skin rash, urinary problems, constipation, wheezing, cramps, pulled muscle, stomach pains, indigestion, gas problems, swelling, etc.)", "that the patient is experiencing for which the patient is seeking medical assistance; however, this is not required.", "The patient registration system may optionally ask one or more follow-up questions after the patient enters the one or more symptoms and/or may inform the patient to seek an in-person visit by a medical provider; however, this is not required.", "The patient registration system may optionally ask the patient to identify one or more known allergies of the patient (e.g., none, amoxicillin, aspirin, bee stings, cosmetics, eggs, fish, hay fever, hives, latex, metals, milk, mold, MSG, nuts, drugs, penicillin, pets, poison ivy, shellfish, soy, sulfa, sun, wheat, other, etc.", "); however, this is not required.", "The patient registration system may optionally ask the patient to identify one or more known medical conditions of the patient (e.g., none, alcoholism, arthritis, asthma, breast cancer, chronic ear infections, diabetes, emphysema, enlarged prostate, glaucoma, heart attack, high blood pressure, high cholesterol, liver problems, cancer, skin cancer, stroke, thyroid problems, tuberculosis, other, etc.", "); however, this is not required.", "The patient registration system may optionally ask the patient to identify one or more past medical procedures that have been performed on the patient; however, this is not required.", "The patient registration system may optionally ask the patient to identify one or more medications the patient is taking; however, this is not required.", "The patient registration system may optionally ask the patient if the patient has medical insurance; however, this is not required.", "If medical insurance is inquired about and the patient indicates that he/she has medical insurance, the patient registration system may optionally ask the patient to enter in the medical insurance information (e.g., insurer name, ID number, policy number, etc.)", "and/or to scan the insurance card; however, this is not required.", "The patient registration system may optionally ask the patient to make a copay based on the medical insurance or to fully pay for the medical visit; however, this is not required.", "Such payments, if any, can be by cash, check, debit card, credit card, smart device, etc.).", "For debit and credit cards and smart devices, the medical kiosk may include a card reader or scanner or RFID system, and/or may include a key pad to enter the charge or credit information; however, this is not required.", "A medical assistant or attendant of the medical kiosk can optionally assist the patient with the payment of services and/or with any other check-in step of the patient registration system; however, this is not required.", "For example, the patient registration system may include a button or other request arrangement to signal to a medical assistance or attendant, if used, that the patient needs assistance with one or more steps of the registration process; however, this is not required.", "Once the patient is registered, the patient registration system will list one or more days and/or times that the medical kiosk is available for use by the patient; however, this is not required.", "The time intervals can be spaced by a certain time period (e.g., every twenty minutes, every thirty minutes, etc.", "); however, this is not required.", "The patient registration system can verify that an appointment has been made by the patient once all of the required information and optional payment has been made; however, this is not required.", "Such verification can be merely displayed on the patient registration system, printed out for the patient, emailed or texted to the patient, or left on a voicemail of the patient; however, this is not required.", "If the patient is a returning patient, the patient may merely need to enter the ID information to access the information that the patient had previously entered and then optionally update such information; however, this is not required.", "A previous patient may be asked about the new visit (e.g., follow-up, new symptoms, etc.", "); however, this is not required.", "The previous patient may optionally be asked to update insurance information, reenter insurance information, etc.", "and then optionally make the required copay or full payment.", "If the returning patient is merely returning to a scheduled appointment, the patient may need to enter the ID information and verify that the patient is present and is checked-in or cancelling the scheduled appointment; however, this is not required.", "A medical assistant or attendant can optionally provide assistance to a patient during any step of the check-in or registration process or recheck-in process; however, this is not required.", "The information entered and/or scanned regarding the patient can optionally be saved to a file for current and/or later access by the patient, medical provider, medical assistant, etc.", "; however, this is not required.", "Such stored information is generally saved on a database, server, etc.", "that is located remote to the medical kiosk; however, this is not required.", "In still another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of one or more medical assistants or attendants with the medical kiosk; however, this is not required.", "Generally, medical assistants or attendants are used with a personal medical kiosk.", "In one non-limiting embodiment of the invention, the medical kiosk can have one or more attendants assist a patient during the use of the medical kiosk (e.g., assist in check-in procedures, assist check-out procedures, assist in entering/exiting the medical kiosk, answering questions about the medical kiosk, assist the patient about the use of the kiosk, assist the patient during examination of the patient by the medical provider, assist in maintaining privacy/security of a patient while using the medical kiosk, assist user during payment of medical services, assist user in obtaining a prescription, assist in answering general questions about the medical kiosk, assist the remote medical provider during the examination of the patient, assist in using one or more medical devices on the patient, cleaning the medical kiosk, maintaining the systems of the medical kiosk, resetting the medical kiosk for use by another patient, assist in processing of payments and/or insurance information of a patient, monitor proper use of the medical kiosk, etc.", "); however, this is not required.", "Such attendant, when used, can be a medical provider or non-medical provider.", "The assistant may or may not have any formal medical education.", "The one or more attendants, when used, can also or alternatively clean and/or sanitize various regions of the medical kiosk prior to and/or after being used by a patient and/or set up the medical kiosk for a new user; however, this is not required.", "For example, prior to and/or after one or more patients have entered the medical kiosk, the one or more attendants can clean/sanitize one or more exterior surfaces and/or regions of the medical kiosk (e.g., medical kiosk door, medical kiosk check-in terminal, medical kiosk desk top, medical kiosk exterior walls, medical kiosk touch screen, medical kiosk monitors, seating/tables in waiting area near medical kiosk, etc.", "); however, this is not required.", "In an another and/or additional example, prior to and/or after one or more patients have entered the medical kiosk, the one or more attendants can clean/sanitize one or more interior surfaces of the medical kiosk (e.g., medical kiosk door, medical kiosk floor, medical kiosk bench, medical kiosk chair, medical kiosk user terminal, medical kiosk interior desk top, medical kiosk interior walls, medical kiosk touch screen, medical kiosk monitors, medical kiosk instrument doors, medical devices/instruments used by and/or touched by user when in the medical kiosk, any other surface in the interior of the medical kiosk, etc.", "); however, this is not required.", "In still another and/or additional example, prior to and/or after one or more patients have entered the medical kiosk, the one or more attendants can set up the medical kiosk for a user (e.g., clean/sanitize interior surfaces of medical kiosk; clean/sanitize medical devices/instruments used and/or touched by a prior user; reposition medical devices/instruments into device storage areas; replace disposable components on medical devices/instruments; replenish paper in a printer; clear a paper jam in a printer; replace batteries for one or more electronic components; close medical device/instrument compartments doors in the medical kiosk; reset user touch screen for next user in the medical kiosk; fix, repair and/or replace non-operating, damaged or broken medical devices/instruments in the medical kiosk; fix, repair and/or replace electronic components, computers, fans, light bulbs, UV bulbs, UV devices, etc.", "in the interior and/or exterior of the medical kiosk; refill cleaning and/or sanitizing fluid; etc.", "); however, this is not required.", "In yet another and/or additional example, the one or more attendants can be used to assist one or more users in the medical kiosk.", "Generally, such assistance will occur only after requested by the user in the medical kiosk or by the medical provider that is assisting the user while in the medical kiosk; however, this is not required.", "For instance, the one or more attendants can assist a user in the medical kiosk if the one or more attendants hear a verbal request from the user, receive notice (e.g., light indicator activated by user, sound indicator activated by user, hear user talking via a speaker to attendant, hear user talking through walls of medical kiosk, receive a notice from the medical provider [e.g., phone call, email, light indicator, etc.", "], etc.", "); however, this is not required.", "The one or more medical assistants can be positioned at a desk or table that is positioned adjacent to or connected to the exterior of the medical kiosk; however, this is not required.", "The medical assistant can be provided with a computer, tablet, etc.", "to monitor the appointment for the medical kiosk, to cancel an appointment, to reschedule and appointment, to indicate if a patient missed an appointment or is late for an appointment, validate the ID of a patient, to view appointment information of the medical kiosk, to validate a patient's insurance, to monitor the need for the assistant to assist a patient via patient or medical provider request, to monitor the status of the visit by the patient (e.g., medical kiosk cleaned for patient, the patient has properly checked-in, appointment has started and vitals capture process has begun, vitals capture process completed, video consultation by medical provider with patient has begun, the video consultation with the medical provider has been completed, the medical provider is completing the patient report, the visit by the patient in the medical kiosk is completed, etc.", "), to assist in insurance and information processing and/or scheduling of a patient, to assist in the payment by the patient for medical services, to print out reports and/or email reports to patient that provide a summary or complete report to the patient regarding the visit to the medical kiosk, to activate the sanitation system of the medical kiosk (e.g., UV sanitation system, etc.", "), to keep a record of when the kiosk was cleaned/sanitized and/or what was cleaned/sanitized by the assistance (e.g., clean patient counter, clean patient touch screen desk, clean patient bench, clean entry doors, clean thermometer, clean dermascope, clean patient chair, clean interior walls, clean medical doors and handles, clean otoscope, clean pulse oximeter, clean floor, clean scale, clean video monitor, clean exterior of the medical kiosk, clean the medical assistant desk, clean the check-in screen on the exterior of the medical kiosk, clean walk-in mat, clean door tracks, clean UVC panel, clean inside ceiling, clean top of medical kiosk, clean UVC lights, clean medical device compartments, etc.", "), to enter information about the operation of the medical kiosk, to schedule a service call for the medical kiosk, to order parts or accessories for the medical kiosk, to verify the start and completion of an appointment, to process comment information by a patient, to create and/or send reports regarding the use of the medical kiosk, to escort the patient into and/or out of the medical kiosk, to begin the vitals capture process of the patient, provide information and/or instructions to a patient regarding the medical kiosk and/or regarding the proper use of the medical kiosk, to assist a potential patient in a tour of the medical kiosk, etc.", "In yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of an Attendant Application; however, this is not required.", "Generally, an Attendant Application is not used with a personal medical kiosk.", "The Attendant Application, when used, includes software and/or hardware that enables the attendant/medical assistant to 1) monitor, modify and/or cancel existing appointments for a medical kiosk, 2) monitor whether a patient requires assistance, 3) monitor and/or assist a patient during registration with the medical kiosk, 4) provide procedures and/or check lists for the medical assistant, and/or 5) provide information on the status of the medical kiosk.", "As can be appreciated, the Attendant Application can have other and/or additional functions.", "In one non-limiting arrangement, the initial Attendant's screen displays one or more appointment fields (e.g., time, patient name, medical provider name, status, action, etc.).", "For example, the time field, when used, can be designed to display the time of upcoming appointments on the medical kiosk; the patient name field, when used, can be designed to display the name of the patients for upcoming appointments on the medical kiosk; the provider name field, when used, can be designed to display the names of the providers for upcoming appointments on the medical kiosk; the status field, when used, can be designed to display the status of upcoming appointments on the medical kiosk (e.g., Ready—The medical kiosk has been sanitized and is ready for the next patient appointment, Checked-In—The patient has been checked-in and their appointment is pending, Pre Consult—The appointment has started and vitals capture process is in progress, In Visit—The vitals capture process has been completed and the video consultation with the medical provider is in progress, Post Consult—The video consultation with the medical provider has been completed and the medical provider is completing the visit, Completed—The appointment has been completed, etc.", "); and the actions field, when used, can be designed to display the availability of the Attendant functions.", "The actions field, when used, can be designed to allow for one or more actions (e.g., “X” icon, Clock icon, Printer icon, Emergency Clean-Up icon, etc.", "The “X” icon, when used, can be design to perform one or more functions such as to cancel an upcoming appointment; however, this is not required.", "The X icon can also allow entry and/or selection of a reason for cancellation (e.g., No Show—This action cancels the appointment, but maintains the patient record; Can't Make Appointment (Not Rescheduling)—This action cancels the appointment, but maintains the patient record; Patient Changed Mind—This action cancels the appointment, but maintains the patient record; Cancel Cancellation—This action cancels the cancellation; etc.).", "The Clock icon, when used, can be designed to reschedule an upcoming appointment; however, this is not required.", "When this icon is selected, entry and/or selection of one or more types of data can be allowed (e.g., input a date and time to reschedule an appointment, etc.", "); however, this is not required.", "The Printer icon, when used, can be designed to print a visit summary and/or some other type of information (e.g., prescription, coupons, follow-up visit information, survey and/or survey results, etc.", "); however, this is not required.", "This icon can be designed to only appear after an appointment has been completed and/or scheduled; however, this is not required.", "The Emergency Clean-Up icon, when used, can be designed to allow the medical attendant to associate an emergency clean-up with a patient appointment so as to be used for tracking purposes and/or some other purpose; however, this is not required.", "Upon selection of the Emergency Clean-Up icon, the medical attendant can be allowed to type a note regarding the emergency clean-up; however, this is not required.", "In still yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of an Attendant Application that allows the medical attendant/medical assistant to 1) view appointment information, 2) validate patient IDs, 3) validate patient insurance, 4) reschedule or cancel an appointment, and/or 5) perform the sanitization process for the medical kiosk; however, this is not required.", "In one non-limiting embodiment of the invention, once the patient is “Checked-In” via the patient registration process, the appointment status changes to “Pending.” At that time, the medical attendant can be required to validate the patient's ID; however, this is not required.", "For example, the medical attendant can 1) select the patient records (e.g., from the computer screen or monitor, etc.)", "and 2) select the “Validate Patient ID” button or similar type of button or selection; however, this is not required.", "If the patient is a new patient, the medical attendant can be prompted to insert and scan the patient's identification for the first time to be saved in the patient's electronic file.", "If the patient is a returning patient, the medical attendant can be prompted to “Update Patient ID”.", "If “Update Patient ID” is selected, the medical attendant can be prompted to “Start Scan” of updated patient ID.", "Once the patient's ID is validated and scanned, the medical attendant may be required to rescan the ID (if image quality is compromised) or save the image in the patient's file; however, this is not required.", "As can be appreciated, other or additional methods can be used to validate a patient's ID.", "In one non-limiting arrangement, the patient's identification is validated by use of a valid driver's license, US passport, military ID, and/or photo ID card issued by Federal, State, or Local government.", "As can be appreciated, other or additional types of IDs can be used.", "If the patient is under 18 or some other age designating a minor, the patient may be required to be accompanied by a parent or legal guardian; however, this is not required.", "If the patient is not accompanied by a parent or legal guardian, the patient may not be allowed to proceed with the visit.", "The medical assistant may be required to inform the under-18 or minor-age patient of certain rights when using the medical kiosk (e.g., It is not necessary for the parent or legal guardian to accompany the under-18 patient into the consultation; Anyone under 18 years of age needs to have parent or legal guardian to use the medical kiosk, etc.", "); however, this is not required.", "If the patient is under a certain age (e.g., 2 years old, etc.", "), the medical attendant may be required to inform the patient, parent and/or guardian that the patient to too young to use the medical kiosk, thus cannot proceed with the visit; however, this is not required.", "If a new patient indicates that they have insurance or a returning patient indicates their insurance information has changed, the patient may be prompted to see the medical attendant and/or be required to enter the insurance information; however, this is not required.", "The Attendant Application can prompt the medical attendant for entry of a copay amount and/or to scan the insurance card into the patient record; however, this is not required.", "As can be appreciated, the patient can enter the insurance information without a medical attendant and/or make a copayment without the medical attendant; however, this is not required.", "Once the patient's insurance is validated and entered and/or scanned, the medical attendant or patient may be required to rescan the ID (if image quality is compromised) and/or reenter the information if not entered properly or save the image and/or entered insurance information into the patient's file; however, this is not required.", "If the insurance information is not verified at a first try, the patient or medical attendant can attempt to reverify the insurance information; however, this is not required.", "Once the patient insurance is saved, the patient can be prompted to “Check in” for the next available appointment or select some appointment time and/or day in the future; however, this is not required.", "Once the patient is checked in for a visit to the kiosk, the appointment status will change to “Pre Consult” or some other statement on the screen of the Attendant Application; however, this is not required.", "At that time, the medical attendant may be required to recite a “Pre-Visit Summary” (e.g., “After your appointment is verified, you will step into the medical kiosk, your vitals are captured and you will meet with a medical provider over a video connection.", "The medical provider will provide the diagnoses and you may receive a prescription.", "The prescription can be sent to a pharmacy of your choice, etc.", "); however, this is not required.", "Once the patient is checked in and after any optional statement is made to the patient, the patient can enter the medical kiosk.", "The medical attendant may be required to escort the patient into the medical kiosk to initiate the vitals capture and/or consultation; however, this is not required.", "The medical attendant and/or patient can cause the Provider Application to prompt the medical provider to start the medical visit; however, this is not required.", "Once the medical provider completes the appointment via the Provider Application, the appointment status on the Attendant Application for a particular patient can be designed to change to “Completed”.", "Once the patient has completed the medical visit and exited the medical kiosk, the medical attendant may be required to perform a sanitization process; however, this is not required.", "Such sanitation process can include the medical attendant 1) selecting the patient record on the screen, and 2) selecting the Start Sanitization button or similar labeled button or selection.", "The medical attendant can enter the medical kiosk and perform the sanitization process.", "A screen that includes a check list or a paper check list can be used by the medical attendant to check off items that have been sanitized.", "For example, a screen inside the medical kiosk can include a check list and the medical assistant checks off each item as such item is sanitized by the medical attendant; however, this is not required.", "When all items are sanitized and optionally checked off, the medical attendant can select a button on the Attendant Application that the sanitation step is completed; however, this is not required.", "The medical attendant can optionally select to “Run UVC Light” or some other or additional automated sanitation system if such option is available; however, this is not required.", "Areas of the medical kiosk that can be cleaned after each visit and/or cleaned at period times based on some protocol are: patient counter, patient monitor screen, physician monitor screen, patient chair, seat at rear of station, kiosk wall panels, medical devices, medical device doors and handles, interior of kiosk, entry door of kiosk, internal wood surfaces in kiosk, attendant station, walk in door mat, floor of kiosk, door track of kiosk, external display monitor of kiosk, external surfaces of kiosk, UVC panel in kiosk, and/or UVC lights.", "The surfaces can be cleaned with wipes (e.g., Virox wipes [Towelettes with disinfecting chemicals that kill 99% of viruses and bacteria], glass cleaner, surface cleaners, floor cleaners, duster, dusting cloth, etc).", "Upon completion of the sanitization process, the medical kiosk status can return to “Ready” on the Attendant Application; however, this is not required.", "At that point, the medical attendant can start validation of the next patient's ID.", "In another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of a Patient Appointment or Registration Application to navigate patients through the vitals capture process, patient consultation, and/or survey; however, this is not required.", "The Patient Appointment or Registration Application can contain one or more navigational buttons on the patient screen that is located inside the medical kiosk (e.g., Back, Next, Cancel, Request Assistance, etc.", "); however, this is not required.", "The Back button, when used, allows the patient to return to the previous screen.", "The Next button, when used, allows the patient to proceed to the next screen.", "The Cancel button, when used, allows the patient to cancel a process and return to the beginning of the process.", "The patient can optionally receive a request to confirm the cancel procedure; however, this is not required.", "The Request Assistance button, when used, allows the patient to request assistance from the medical attendant.", "The selection of this button can be designed to also notify the patient that the medical attendant will be with them in a moment; however, this is not required.", "The selection of the Request Assistance button by the patient can result in the Attendant Application displaying on a screen a notice or generating a warning sound, etc.", "that the patient has requested assistance.", "For example, when the patient initiates the Request Assistance button, a pop-up box (e.g., orange box, red box, blue box, etc.)", "can appear on the medical attendant's screen that is labeled “kiosk,” colored orange, and indicates the patient requires assistance.", "As can be appreciated, the screen of the Provider Application, when used, can include an Alert Attendant button to notify the medical attendant that the patient requires assistance; however, this is not required.", "If the medical provider initiates the Alert Attendant button from the Provider Application, a pop-up box can be designed to appear on the medical attendant's screen that indicates the patient requires assistance.", "The pop-up box can be a colored box (e.g., red box, green box, orange box, etc.", "); however, this is not required.", "A sound can also or alternatively be generated by the Attendant Application, when used, to notify the medical attendant that the medical provider has selected the Alert Attendant button; however, this is not required.", "The Patient Appointment or Registration Application, when used, can be designed to allow the patient to 1) capture vitals, 2) perform the provider consultation, and/or 3) perform the survey.", "As can be appreciated, the Patient Appointment or Registration Application, when used, can be designed to allow the patient to perform other or additional functions.", "The Patient Appointment or Registration Application can be designed to appear on the Patient Screen and/or Provider Screen that are located in the interior of the medical kiosk; however, this is not required.", "The Provider Screen, when used, is the screen that is located above or adjacent to the Patient Screen; however, this is not required.", "The medical provider generally appears on the Provider Screen when the consultation starts; however, this is not required.", "The Patient Screen, when used, can provide information to the patient while located in the kiosk and/or allow the patient to enter information (e.g., patient receives vitals capture instructions on the Patient Screen and enters information as prompted, etc.).", "The Patient Appointment or Registration Application can be designed to capture vitals of the patient.", "The Patient Appointment or Registration Application can be designed to require the patient to initiate the vitals capture procedure and/or the medical attendant can initiated the vitals capture procedure for the patient.", "The Patient Appointment or Registration Application can be designed to navigate the patient and/or provide instructions to the patient for one or more of the vitals capture procedures; however, this is not required.", "During the vitals capture process, the patient can request that the medical assistant assist the patient in one or more of the procedures for capturing the vitals; however, this is not required.", "The Patient Appointment or Registration Application can be designed to require the patient to confirm that instructions for a particular vital capture procedure have been read and/or understood before proceeding with the next vital capture step; however, this is not required.", "The Patient Appointment or Registration Application can be designed to have the patient enter his/her height on the Provider Screen and/or Patient Screen; however, this is not required.", "The interior of the medical kiosk can include a height marker or height tape to enable a patient to determine his/her height; however, this is not required.", "The medical kiosk can include a camera or some other type of arrangement that can be used to automatically determine the height of the patient while the patient is positioned in the medical kiosk; however, this is not required.", "The Patient Appointment or Registration Application can be designed have the patient enter his/her weight on the Provider Screen and/or Patient Screen; however, this is not required.", "The interior of the medical kiosk can include a scale (e.g., built-in floor scale, etc.)", "that can be used by the patient to determine the patient's weight; however, this is not required.", "When a scale is provided in the medical kiosk, the weight can be automatically transferred to the Patient Appointment or Registration Application and/or can be manually entered by the patient.", "The Patient Appointment or Registration Application can be designed to have the patient obtain his/her temperature.", "The Patient Appointment or Registration Application can be designed to open a medical device cabinet that contains a thermometer; however, this is not required.", "The Patient Appointment or Registration Application can be designed to provide instructions and/or a video on how to use the thermometer (e.g., a) remove thermometer from open medical cabinet, b) place thermometer in ear, c) remove thermometer from ear after hearing a beep sound or other indicator that indicates procedure is completed, d) return thermometer to medical cabinet, etc.", "); however, this is not required.", "The Patient Appointment or Registration Application can be designed to have the patient obtain his/her blood pressure.", "The Patient Appointment or Registration Application can be designed to open a medical device cabinet that contains a blood pressure cuff and/or allows the blood pressure cuff to be plugged into the medical kiosk; however, this is not required.", "The Patient Appointment or Registration Application can be designed to provide instructions and/or a video on how to use the blood pressure cuff; however, this is not required.", "As can be appreciated, the medical attendant can place the blood pressure cuff on the patient entering the medical kiosk and/or after the patient has entered the medical kiosk; however, this is not required.", "If the blood pressure cuff requires that it be connected to the medical kiosk, the medical attendant or the patient can perform such connection.", "The patient or the medical attendant can start the blood pressure reading by selecting a button on the Patient Appointment or Registration Application; however, this is not required.", "The blood pressure cuff can be used to measure the blood pressure/heart rate of a patient.", "A real-time reading of the blood pressure/heart rate of a patient can be displayed on the Patient Screen and/or Provider Screen; however, this is not required.", "The patient or medical attendant can stop the process of capturing the blood pressure/heart rate of the patient; however, this is not required.", "After the completion of capturing all the vitals, the Patient Appointment or Registration Application can be designed to display on the Patient Screen and/or Provider Screen a summary of one or more of the captured vitals.", "The Patient Appointment or Registration Application can be designed to allow a patient to manually change one or more of the collected vitals; however, this is not required.", "Once the vitals capture process is completed, the patient can be prompted (e.g., “I'm Ready” button, etc.)", "to indicate that the patient is ready for the conference with the medical provider; however, this is not required.", "The Patient Appointment or Registration Application can be designed to notify the patient that the medical provider will be with them shortly; however, this is not required.", "Once the consultation has begun, the Patient Appointment or Registration Application can be designed to cause the medical provider to appear on the lower half of the Provider Screen and the patient's vitals appear on the upper half of the Provider Screen; however, this is not required.", "As can be appreciated, the full Provider Screen can only include the medical provider.", "The Patient Appointment or Registration Application can be designed to allow the patient to adjust the volume by use of volume buttons on the Patient Screen; however, this is not required.", "As can be appreciated, volume control can be located in other or additional locations in the medical kiosk.", "After the completion of the consultation, the Patient Appointment or Registration Application can be designed to ask the patient to complete a survey; however, this is not required.", "The Patient Appointment or Registration Application can be designed to allow the patient to skip the survey, when used, or to proceed with the survey; however, this is not required.", "If the patient selects the survey, when offered, one or more questions can be displayed on the Patient Screen and/or Provider Screen; however, this is not required.", "As can be appreciated, the medical attendant can provide the patient with a written survey and/or ask verbal survey questions; however, this is not required.", "At the completion of the survey, or if the patient chooses to skip the survey when such survey is offered, the Patient Appointment or Registration Application can be designed display a final screen thanking the patient for his/her visit and/or prompting them to request a visit summary from the medical attendant; however, this is not required.", "In still another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of a Provider Application that is designed to enable the medical provider to navigate through the appointment process during the patient appointment; however, this is not required.", "The Provider Application can be designed to allow the medical provider to a) display appointments, b) display patient information, c) view and/or modify visit information, d) perform the consultation, and/or e) utilize one or more medical devices in the medical kiosk.", "The Provider Application can be designed to cause screens to appear on the medical provider's computer, smart phone, smart TV, tablet, etc.", "at the medical provider's remote location; however, this is not required.", "The Provider Application can be designed to enable the medical provider to view appointments that have been completed by the medical provider, that are in progress by the medical provider and/or which are future appointments.", "In one non-limiting arrangement, the Provider Application can be designed to enable the medical provider to view appointments that have been completed by the medical provider or are in progress for a certain day (e.g., today, last Monday, etc.).", "In another non-limiting arrangement, the Provider Application can be designed to enable the medical provider to view appointments that have been made for a future time (e.g., two hours from the present, the next day, etc.).", "For example, the Provider Application can be designed to display on one portion of the screen (e.g., left side, right side, center, etc.)", "appointments for Today and Future.", "In one non-limiting arrangement, the Today tab can be designed to display one or more types of patient appointment information (e.g., Time—Time of appointment, Patient Name—Patient Name for appointment, Status—Status of appointment, Pending—Patient started the registration process, but has not yet been approved for payment, Checked-In—Patient has been checked-in, Pre Consult—Appointment has started and vitals are being collected, In Visit—Vitals have been collected and the video consultation is in-progress, Post Consult—Video consultation has been completed and medical provider completion is pending, Completed—Appointment has been completed, etc.).", "The Future tab can be designed to display one or more types of patient appointment information (e.g., Date—Date of appointment, Time—Time of appointment, Patient Name—Patient Name for appointment, etc.).", "The Provider Application can be designed to enable the medical provider to view a selected record on another portion of the screen; however, this is not required.", "The selected record can provide the medical provider one or more types of information (e.g., Patient Name, Patient Date of Birth, Patient Sex, Symptoms, Medical Conditions, Date of Last Visit, Diagnosis, Allergies, Medications, Prior Visit Record of Patient, Medical Records of Patient, etc.).", "The Provider Application can be designed to enable the medical provider to notify the medical attendant that the patient requires assistance; however, this is not required.", "The Provider Application can be designed to enable the medical provider to view the appointment and/or patient information prior to the vitals capture process.", "The Provider Application can be designed to limit access to a patient's information until a certain point (e.g., patient status is Checked-In, etc.", "); however, this is not required.", "The Provider Application can be designed to enable the medical provider to refuse an appointment that has been created for the medical provider; however, this is not required.", "Generally, such refusal should occur prior to the patient status of Checked-In to enable the system to locate another available medical provider; however, this is not required.", "The Provider Application can be designed to allow the medical provider to begin the conference with the patient once the patient is ready in the medical kiosk (e.g., after Check-In, after Capture of Vitals, etc.", "); however, this is not required.", "The Provider Application can be designed to cause a Start Visit button or similar button to appear on the medical provider's screen to allow the medical provider to begin the consultation with the patient; however, this is not required.", "Once the visit or consultation has been initiated, the Provider Application can be designed to update the appointment status to In Visit; however, this is not required.", "Once the visit or consultation has begun, the patient appears on a portion of the medical provider's screen (e.g., right side of screen, center of screen, left side of screen, etc.", "); however, this is not required.", "The medical provider may greet the patient in the medical kiosk with a greeting (e.g., “Welcome.", "Can you see me ok?", "Can you hear me ok?”, etc.", "); however, this is not required.", "The Provider Application can be designed to cause an End Consultation or similar button to appear on the medical provider's screen to terminate the consultation or visit with the patient and thereby terminate the video link between the medical provider and patient in the medical kiosk; however, this is not required.", "Once the consultation or visit with the patient is terminated, the Provider Application can be designed to cause the status of the patient to change to Post Consult; however, this is not required Post Consult means the video consultation has been completed and the medical provider is completing the visit summary.", "Once the medical provider has completed the visit summary and written any required prescriptions, the Provider Application can be designed to cause a Complete Appointment or similar button to appear on the medical provider's screen; however, this is not required.", "The selection of the Complete Appointment button or similar button after completion of the video consultation can result in the status of the patient to change to Completed; however, this is not required.", "Completed means the medical provider has completed input of all information and is ready to commence the next appointment.", "The Provider Application can be designed to allow the medical provider to view the patient records, including the vitals capture process that has occurred or is occurring in the medical kiosk.", "The Provider Application can be designed to cause one or more tabs to be displayed on the medical provider's screen once a patient record has been selected (e.g., Patient Information, Current Visit, Previous Visit, etc.).", "The Patient Information tab, when used, can list one or more types of information of the patient on the medical provider's screen (e.g., Personal Information, Medications, Allergies, Medical Conditions, etc.).", "One or more of these categories of information can be further expanded upon selection by the medical provider; however, this is not required.", "For example, selection of the Personal Information category can cause further information about the patient to be displayed (e.g., date of birth, sex, alcohol usage, smoker status, allergies, patient personality traits, marriage status, medication usage, drug history, psychological profile, recent medical/psychological issues, medical/drug compliance, profile, race, eye color, native language, citizenship, address, etc.", "); however, this is not required.", "The Current Visit tab, when used, can list one or more types of information about the patient on the medical provider's screen (e.g., Medications, Notes, Vitals, Devices, Visit Summary, Attendant Instructions, etc.).", "One or more of these categories of information can be further expanded upon selection by the medical provider; however, this is not required.", "For example, selection of the Medications category can cause further information about medications used by the patient (e.g., past medications used, past medications prescribed to patient, current medications used by the patient, medication compliance, etc.).", "The Previous Visit tab, when used, can list one or more types of information of the patient on the medical provider's screen (e.g., Symptoms, Notes, Vitals, Visit Summary, etc.).", "One or more of these categories of information can be further expanded upon selection by the medical provider; however, this is not required.", "For example, selection of the Vitals category can cause further information about the vitals that were captured during a previous visit to the current medical kiosk, some other medical kiosk, or at some other medical facility.", "In one non-limiting embodiment of the invention, the Provider Application is designed to cause at least three tabs to be displayed on the medical provider's screen once a patient record has been selected, namely Patient Information, Current Visit, and Previous Visit.", "The Patient Information tab contains sections for Personal Information, Medications, Allergies, and Medical Conditions; however, it can be appreciated that other or additional tab sections can be included.", "The Personal Information section contains one or more sub-sections, of which some or all the information was entered by the patient during the registration process.", "This information generally cannot be modified by the medical provider; however, this is not required.", "Non-limiting examples of information that can be displayed in the Personal Information section includes Date of Birth, Gender—Male or Female, Alcohol Use, Smoker status, Height, Age, Contact Information, Race, Eye Color, Hair Color, Native Language, Citizenship, Address, Psychological profile, etc.", "The Medications section allows the medical provider to see previously entered medications, search and select new medications, remove medications the patient is no longer taking, view medication compliance history of patient, etc.", "The Provider Application can be designed to allow a medical provider to add a medication by having the medical provider type in the medication and/or to start typing the medication name in the Search Medications drop down and allow a listing of matching medication names to appear for selection and then to select the proper medication.", "The Provider Application can be designed to allow a medical provider to delete a medication by having the medical provider select an X next to the medication.", "As can be appreciated, other or additional arrangements can be used to add and/or delete medications in a patient's record.", "The Allergies section allows the medical provider to view allergies as input by the patient.", "This function allows the medical provider to see previously entered allergies, search and select new allergies, and/or remove allergies.", "The Provider Application can be designed to allow a medical provider to add an allergy by having the medical provider type in the allergy and/or to start typing the allergy name in the Add Allergy dropdown and allow a listing of matching allergy names to appear for selection and then to select the proper allergy.", "The Provider Application can be designed to allow a medical provider to delete an allergy by having the medical provider select an “X” next to the allergy.", "As can be appreciated, other or additional arrangements can be used to add and/or delete allergies in a patient's record.", "The Medical Conditions section allows the medical provider to view patient medical conditions as input by the patient.", "This function allows the medical provider to see previously entered medical conditions, search and select new medical conditions, and/or remove medical conditions.", "The Provider Application can be designed to allow a medical provider to add a medical condition by having the medical provider type in the medical condition and/or to start typing the medical condition in the Add Medical Condition dropdown and allow a listing of matching medical condition names to appear for selection and then to select the proper medical condition.", "The Provider Application can be designed to allow a medical provider to delete a medical condition by having the medical provider select an X next to the medical condition.", "As can be appreciated, other or additional arrangements can be used to add and/or delete medical conditions in a patient's record.", "The Current Visit tab contains sections for Symptoms, Notes, Vitals, Devices, Visit Summary, and Attendant; however, it can be appreciated that other or additional tab sections can be included.", "The Symptoms section contains all of the patient's symptoms for the current visit as input by the patient.", "This function allows the medical provider to see entered symptoms, search and select new symptoms, and remove symptoms.", "The Provider Application can be designed to allow a medical provider to add a symptom by having the medical provider type in the symptom and/or to start typing the symptom in the Symptoms dropdown and allow a listing of matching symptom names to appear for selection and then to select the proper symptom.", "The Provider Application can be designed to allow a medical provider to delete a symptom by having the medical provider select an “X” next to the symptom.", "As can be appreciated, other or additional arrangements can be used to add and/or delete symptoms in a patient's record.", "The Notes section allows the medical provider to enter notes for the current visit.", "This information generally does not appear on the Appointment Summary and is intended for internal reference only; however, this is not required.", "The Provider Application can be designed to allow a medical provider to add or delete a note by typing a note in the note texted box or by deleting a note in the note text box.", "As can be appreciated, other or additional arrangements can be used to add and/or delete notes in a patient's record.", "The Vitals section contains the patient's vitals for the current visit.", "They are displayed dynamically on the provider's screen as the vitals capture process takes place; however, this is not required.", "This function allows the medical provider to see the vitals prior to starting and during the consultation; however, this is not required.", "This information is generally only displayed and cannot be updated; however, this is not required.", "Non-limiting vitals can include Height, Weight, Blood Pressure, Heart Rate, Oxygen Saturation, and Temperature.", "The Devices section contains icons of the medical devices that are located in the medical kiosk and/or can be used with the medical kiosk.", "On the interior of the medical kiosk, there can optionally be one or more medical containers/cabinets (e.g., 1-10, 2, 4, 6, etc.", "), wherein one or more can be locked upon patient entry into the medical kiosk.", "As can be appreciated, personal medical kiosks and other types of medical kiosks may or may not include and/or container/cabinets.", "The medical provider has the capability to unlock one or more of the medical cabinets in the medical kiosk as necessary.", "When the medical provider wants to unlock a medical device cabinet, the medical provider clicks on or selects the appropriate medical device icon on the medical provider's computer screen.", "This selection action can result in the activation of the medical device and/or the opening of the medical cabinet door that includes the selected medical device.", "As can be appreciated, the medical device cabinet can be opened by other or additional means.", "An audible sound can be generated (e.g., sound of dropping door, sound of a lock unlocking, etc.)", "when access to a medical cabinet is granted to a patient; however, this is not required.", "As can be appreciated, a visual indicator can also or alternatively be used to indicate that a patient can access a particular medical cabinet; however, this is not required.", "For personal medical kiosks, medical cabinets are not typically used.", "For personal medical kiosks, the medical provider generally informs the patient to use a particular medical device.", "Non-limiting medical devices that can be used during the use of the medical kiosk can include a thermometer, otoscope, stethoscope, dermascope, pulse oximeter, spirometer, blood pressure cuff, blood sugar analyzer, Blood Pressure Cuff, blood analyzer, etc.", "As can be appreciated, the medical attendant, when used, can provide one or more medical devices to a patient prior to and/or during the visit (e.g., blood pressure cuff, etc.).", "The Visit Summary section can be comprised of one or more sub-sections, some or all of which are input by the medical provider (e.g., Current Diagnoses, Treatment Plan, Follow-Up Care, Visit Documents, etc.", "); however, this is not required.", "The Current Diagnoses section, when used, allows for the provider to input diagnoses codes and descriptions for the current visit.", "The medical provider can update and/or enter a diagnoses by entering the name of the diagnoses and/or an ICD code in a drop down menu and/or search menu.", "Once the diagnoses name has been entered and/or searched and located, the medical provider can add the diagnoses to the patient's record.", "More than one diagnoses can be added to a patient's record during a single visit.", "Once the one or more diagnoses are entered, such diagnoses can be optionally displayed under the Current Diagnoses section.", "The Treatment Plan section, when used, allows for the medical provider to input a treatment plan for the current visit.", "Such treatment plan can be typed by the medical provider into a text box and this information can appear on the Appointment Summary for the patient to reference; however, this is not required.", "The Follow-Up Care section, when used, allows for the medical provider to input follow-up care for the current visit.", "Such follow-up care plan can be typed by the medical provider into a text box; however, this is not required.", "This information can appear on the Appointment Summary for the patient to reference; however, this is not required.", "The Visit Document section, when used, allows for the medical provider to input follow-up care for the current visit.", "The medical provider can include one or more visit documents and/or other types of documents (e.g., documents about the common cold, documents about rashes, documents about the flu, documents about lice, documents about acne, documents about abstinence/birth control, documents about drug usage/abuse, documents about alcohol usage/abuse, documents about child care, documents about personal hygiene, etc.)", "which can be provided to the patient along with the Appointment Summary; however, this is not required.", "The Attendant Instructions section, when used, allows for the medical provider to input attendant instructions for the current visit.", "Such information can be entered into a text box by the medical provider.", "This information may or may not be provided to the patient.", "The Previous Visit tab contains information about prior medical visits by the patient.", "When the Previous Visit tab is selected, a dropdown appears containing the dates of all previous visits.", "The medical provider can select a previous visit and then review information about the previous visit.", "Typically, the medical provider can only view one previous visit at a time.", "In one non-limiting arrangement, when the previous visit date is selected, one or more sections are displayed (e.g., Symptoms, Notes, Vitals, Visit summary, etc.).", "The Symptoms section, when used, allows for the medical provider to view all of the patient's symptoms from the previous visit as input by the patient and/or medical provider.", "The Notes section, when used, allows the medical provider to view all notes for the previous visit that were input by the medical provider in the prior visit.", "The Vitals section, when used, allows for the medical provider to view all of the patient's vitals that were captured during previous visits.", "The Visit Summary section, when used, allows for the medical provider to view all visit summary information input during a prior visit.", "This section can include one or more subsections (e.g., Treatment Plan, Follow-up Care, Visit Documents, etc.).", "In yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a method and a kiosk wherein before the video-conference between the medical provider and the patient begins, each patient starts with a Vitals Check to capture the following one or more of the information: Height, Weight, Temperature, Blood Pressure and/or Heart Rate.", "Thereafter, the patient and/or medical assistant can inform the medical provider that the visit is ready to begin; however, this is not required.", "In still yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a method and a kiosk wherein the kiosk includes one or more (e.g., six, etc.)", "advanced medical device cabinets which are locked upon patient entry; however, this is not required.", "Generally, the personal medical kiosk does not include the use of medical device cabinets.", "As can be appreciated, other types of kiosks may not include medical device cabinets.", "During the patient consultation, the medical provider has the capability to unlock and open these cabinets from the Provider Application on the Provider's computer; however, this is not required.", "The following medical devices can be contained within the cabinets: a thermometer, an otoscope, a stethoscope, a dermascope, a pulse oximeter, blood analyzer, and/or a blood pressure cuff Other or additional medical devices can be included in the medical kiosk (e.g., scale, height tape, eye chart, blood sugar analyzer, defibrillator, etc.).", "As can be appreciated, these medical devices can also be used with the personal medical kiosk.", "The stethoscope, when used, is used for detecting sounds produced in the body that are conveyed to the ears of the listener.", "The medical kiosk stethoscope sounds are transmitted from the stethoscope in the medical device (e.g., hardwire, USB, Bluetooth, Wi-Fi, etc.)", "to the medical provider's stethoscope.", "On the interior of the medical kiosk, the stethoscope can be contained in the first medical device cabinet on the left, when used; however, this is not required.", "The stethoscope can be activated by the medical provider via the Provider Application by the medical provider selecting the Stethoscope icon the provider's screen; however, the stethoscope can be activated by other or additional arrangements or always remain active.", "In one non-limiting arrangement, when the medical provider via the Provider Application selects the stethoscope icon on the provider's screen, the cabinet door in the medical kiosk for the stethoscope opens (e.g., drops down, etc.)", "to enable the patient in the medical kiosk to access the stethoscope; however, this is not required.", "The medical provider can provide instructions to the patient on how to use the stethoscope (e.g., Once the patient has removed the device, request for patient to turn on the stethoscope on the stethoscope device.", "The “On” button is the lower most button on the device; it looks like a smiley face with one eye.", "Tell the patient to attempt to hold the device on the sides, while using it, so other buttons are not depressed, etc.)", "and/or instructions for use of the stethoscope can be provided on the Patient Screen and/or Provider Screen in the medical kiosk; however, this is not required.", "When the stethoscope is selected, a video image can be designed to appear on the Provider Application (e.g., medical provider's screen) and/or the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk.", "If a video image option is available for display on the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk, the medical provider via the Provider Application can turn off such video image on the Provider Screen and/or Patient Screen; however, this is not required.", "The medical provider via the Provider Application can capture images and/or data generated by the stethoscope and/or video camera in the medial kiosk for placement in the patient's file; however, this is not required.", "The medical provider via the Provider Application can optionally annotate an image once captured (e.g., use the paint brush and font icons to modify image, etc.)", "and/or show the captured image to the patient; however, this is not required.", "The medical provider via the Provider Application can increase and/or decrease the volume received from the stethoscope; however, this is not required.", "As can be appreciated, the patient can increase and/or decrease the volume from the stethoscope; however, this is not required.", "The medical provider and/or patient can request assistance by the medical assistant, when available, related to the stethoscope if so required.", "The otoscope, when used, is a device used for examining the internal ear.", "The image generated by the otoscope in the medical kiosk can be displayed on the Patient's Screen and/or Provider's Screen in the medical kiosk and/or on the screen being used by the medical provider; however, this is not required.", "The transmission of the signal can be by various means (e.g., hardwire, USB, Bluetooth, Wi-Fi, etc.).", "On the interior of the medical kiosk, the otoscope can be contained in the second medical device cabinet on the left in the medical kiosk, when a cabinet is used; however, this is not required.", "The otoscope can be activated by the medical provider via the Provider Application by the medical provider selecting the otoscope icon on the provider's screen; however, the otoscope can be activated by other or additional arrangements or always be on.", "In one non-limiting arrangement, when the medical provider via the Provider Application selects the otoscope icon on the provider's screen, the cabinet door in the medical kiosk for the otoscope opens (e.g., drops down, etc.)", "to enable the patient in the medical kiosk to access the otoscope; however, this is not required.", "The medical provider can provide instructions to the patient on how to use the otoscope (e.g., Once the patient has pulled out the device, request for patient to place the otoscope in the appropriate ear lobe, then adjust the focus dial.", "The focus dial is on the top of the otoscope.", "The patient can push it to the top and then dial it down to determine to focus; To direct the patient to maneuver the otoscope for best image capture, use the interior of the medical kiosk as reference points.", "Once the device is in the patient's ear canal, instruct them (or the individual assisting them) to move the device towards the front, back, bottom, and top of the medical kiosk, etc.)", "and/or instructions for use of the otoscope can be provided on the Patient Screen and/or Provider Screen in the medical kiosk; however, this is not required.", "When the otoscope is selected, a video image can be designed to appear on the Provider Application (e.g., medical provider's screen) and/or the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk.", "If a video image option is available for display on the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk, the medical provider via the Provider Application can turn off such video image on the Provider Screen and/or Patient Screen; however, this is not required.", "The medical provider via the Provider Application can capture images and/or data generated by the otoscope and/or video camera in the medial kiosk for placement in the patient's file; however, this is not required.", "The medical provider via the Provider Application can optionally annotate an image once captured (e.g., use the paint brush and font icons to modify image, etc.)", "and/or show the captured image to the patient; however, this is not required.", "The medical provider via the Provider Application can adjust the focus of the otoscope; however, this is not required.", "As can be appreciated, the patient can adjust the focus of the otoscope; however, this is not required.", "The medical provider and/or patient can request assistance, when available, by the medical assistant related to the otoscope if so required.", "The thermometer, when used, is used for detecting human internal heat.", "The temperature that is transmitted by the thermometer can be displayed on the Patient's Screen and/or Provider's Screen in the medical kiosk and/or on the screen being used by the medical provider; however, this is not required.", "The transmission of the signal can be by various means (e.g., hardwire, USB, Bluetooth, Wi-Fi, etc.).", "On the interior of the medical kiosk, the thermometer can be contained in the third medical device cabinet on the left in the medical kiosk, when a cabinet is used; however, this is not required.", "The patient's temperature can be collected during the vitals capture process which is prior to the consultation with the medical provider; however, this is not required.", "If the medical provider wants the temperature to be retaken or if the temperature of the patient has not already been taken, the thermometer can be activated or reactivated by the medical provider via the Provider Application by the medical provider selecting the thermometer icon on the provider's screen; however, the thermometer can be activated by other or additional arrangements or always be on.", "In one non-limiting arrangement, when the medical provider via the Provider Application selects the thermometer icon on the provider's screen, the cabinet door in the medical kiosk for the thermometer opens (e.g., drops down, etc.", "), if not already open, to enable the patient in the medical kiosk to access the thermometer; however, this is not required.", "The medical provider can provide instructions to the patient on how to use the thermometer (e.g., Once the patient has pulled out the device, request for patient to turn on the thermometer.", "The “On” button is on the inside handle of the device; Request for the patient to insert the thermometer into their ear and press the button on top of the handle to start the reading.", "Once the patient's temperature is collected, a beep will sound; Once the beep is sounded to indicate the temperature reading has completed, the patient can hit the “Temperature Recorded” button on the patient screen, etc.)", "and/or instructions for use of the thermometer can be provided on the Patient Screen and/or Provider Screen in the medical kiosk; however, this is not required.", "When the thermometer is selected, a video image can be designed to appear on the Provider Application (e.g., medical provider's screen) and/or the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk.", "If a video image option is available for display on the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk, the medical provider via the Provider Application can turn off such video image on the Provider Screen and/or Patient Screen; however, this is not required.", "The medical provider via the Provider Application can capture images and/or data generated by the thermometer and/or video camera in the medial kiosk for placement in the patient's file; however, this is not required.", "The medical provider via the Provider Application can optionally annotate an image once captured (e.g., use the paint brush and font icons to modify image, etc.)", "and/or show the captured image to the patient; however, this is not required.", "The medical provider and/or patient can request assistance by the medical assistant, when available, if so required.", "In one non-limiting arrangement, the temperature must register between 95.0 degrees and 105.9 degrees; however, this is not required.", "Temperatures under or above 95.0 degrees or some other temperature and 105.9 degrees or some other temperature can be designed to create an error and request the patient to manually enter their temperature, request the patient to try again to take a proper temperature, and/or request the medical assistant to assist the patient related to the thermometer; however, this is not required.", "The dermascope, when used, is used to visualize body surface, skin, hair, scalp, eyes, and/or throat with magnification and/or illumination.", "The image generated by the dermascope in the medical kiosk can be displayed on the Patient's Screen and/or Provider's Screen in the medical kiosk and/or on the screen being used by the medical provider; however, this is not required.", "The transmission of the signal can be by various means (e.g., hardwire, USB, Bluetooth, Wi-Fi, etc.).", "On the interior of the medical kiosk, the dermascope can be contained in the first medical device cabinet on the right in the medical kiosk, when a cabinet is used; however, this is not required.", "The dermascope can be activated by the medical provider via the Provider Application by the medical provider selecting the dermascope icon on the provider's screen; however, the dermascope can be activated by other or additional arrangements or always be on.", "In one non-limiting arrangement, when the medical provider via the Provider Application selects the dermascope icon on the provider's screen, the cabinet door in the medical kiosk for the dermascope opens (e.g., drops down, etc.)", "to enable the patient in the medical kiosk to access the dermascope; however, this is not required.", "The medical provider can provide instructions to the patient on how to use the dermascope (e.g., Once the patient has pulled out the device, request for patient to place the dermascope device at the appropriate place, then request for the patient to adjust the focus dial.", "The focus dial is on the top handle of the dermascope.", "The patient can push it to the top and then dial it down to determine appropriate focus, etc.)", "and/or instructions for use of the dermascope can be provided on the Patient Screen and/or Provider Screen in the medical kiosk; however, this is not required.", "When the dermascope is selected, a video image can be designed to appear on the Provider Application (e.g., medical provider's screen) and/or the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk.", "If a video image option is available for display on the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk, the medical provider via the Provider Application can turn off such video image on the Provider Screen and/or Patient Screen; however, this is not required.", "The medical provider via the Provider Application can capture images and/or data generated by the dermascope and/or video camera in the medial kiosk for placement in the patient's file; however, this is not required.", "The medical provider via the Provider Application can optionally annotate an image once captured (e.g., use the paint brush and font icons to modify image, etc.)", "and/or show the captured image to the patient; however, this is not required.", "The medical provider via the Provider Application can adjust the focus of the dermascope; however, this is not required.", "As can be appreciated, the patient can adjust the focus of the dermascope; however, this is not required.", "The medical provider and/or patient can request assistance by the medical assistant, when available, related to the dermascope if so required.", "The pulse oximeter, when used, is used for measuring the amount of saturated hemoglobin the tissue capillaries by transmitting a beam of light through the tissue to a receiver.", "The image generated by the pulse oximeter in the medical kiosk can be displayed on the Patient's Screen and/or Provider's Screen in the medical kiosk and/or on the screen being used by the medical provider; however, this is not required.", "The transmission of the signal can be by various means (e.g., hardwire, USB, Bluetooth, Wi-Fi, etc.).", "On the interior of the medical kiosk, the pulse oximeter can be contained in the second medical device cabinet on the right in the medical kiosk, when a medical cabinet is used; however, this is not required.", "The pulse oximeter can be activated by the medical provider via the Provider Application by the medical provider selecting the pulse oximeter icon on the provider's screen; however, the pulse oximeter can be activated by other or additional arrangements or always be on.", "In one non-limiting arrangement, when the medical provider via the Provider Application selects the pulse oximeter icon on the provider's screen, the cabinet door in the medical kiosk for the pulse oximeter opens (e.g., drops down, etc.)", "to enable the patient in the medical kiosk to access the pulse oximeter; however, this is not required.", "The medical provider can provide instructions to the patient on how to use the pulse oximeter (e.g., Provider: Once the patient has pulled out the device, request for patient to place the device on their index finger as illustrated by the diagram on the top on the device.", "The picture is a fingernail print which should align to the patient's fingernail, etc.)", "and/or instructions for use of the pulse oximeter can be provided on the Patient Screen and/or Provider Screen in the medical kiosk; however, this is not required.", "When the pulse oximeter is selected, a video image can be designed to appear on the Provider Application (e.g., medical provider's screen) and/or the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk.", "If a video image option is available for display on the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk, the medical provider via the Provider Application can turn off such video image on the Provider Screen and/or Patient Screen; however, this is not required.", "The medical provider via the Provider Application can capture images and/or data generated by the pulse oximeter and/or video camera in the medial kiosk for placement in the patient's file; however, this is not required.", "The medical provider via the Provider Application can optionally annotate an image once captured (e.g., use the paint brush and font icons to modify image, etc.)", "and/or show the captured image to the patient; however, this is not required.", "The medical provider via the Provider Application can adjust the focus of the pulse oximeter; however, this is not required.", "As can be appreciated, the patient can adjust the focus of the pulse oximeter; however, this is not required.", "The medical provider and/or patient can request assistance by the medical assistant, when available, related to the pulse oximeter if so required.", "The scale, when used, is used to obtain the weight of the patient.", "The weight that is transmitted by the scale can be displayed on the Patient's Screen and/or Provider's Screen in the medical kiosk and/or on the screen being used by the medical provider; however, this is not required.", "The transmission of the signal from the scale can be by various means (e.g., hardwire, USB, Bluetooth, Wi-Fi, etc.).", "As can be appreciated, the weight can be manually entered.", "On the interior of the medical kiosk, when the kiosk has an interior enclosure, the scale can be located on the floor of the medical kiosk; however, this is not required.", "The patient's weight can be collected during the vitals capture process which is prior to the consultation with the medical provider; however, this is not required.", "If the medical provider wants the patient's weight to be retaken or if the patient's weight has not already been taken, the scale can be activated or reactivated by the medical provider via the Provider Application by the medical provider selecting the thermometer icon on the provider's screen; however, the scale can be activated by other or additional arrangements.", "In one non-limiting arrangement, when the medical provider via the Provider Application selects the scale icon on the provider's screen, information from the scale or information that is manually entered is conveyed to the medical provider; however, this is not required.", "The medical provider can provide instructions to the patient on how to use the scale (e.g., Request for the patient to step on the scale and wait for the recording to be completed, etc.)", "and/or instructions for use of the scale can be provided on the Patient Screen and/or Provider Screen in the medical kiosk; however, this is not required.", "When the scale is selected, a video image can be designed to appear on the Provider Application (e.g., medical provider's screen) and/or the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk.", "If a video image option is available for display on the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk, the medical provider via the Provider Application can turn off such video image on the Provider Screen and/or Patient Screen; however, this is not required.", "The medical provider via the Provider Application can capture images and/or data generated by the scale and/or video camera in the medial kiosk for placement in the patient's file; however, this is not required.", "The medical provider via the Provider Application can optionally annotate an image once captured (e.g., use the paint brush and font icons to modify image, etc.)", "and/or show the captured image to the patient; however, this is not required.", "The medical provider and/or patient can request assistance by the medical assistant, when available if so required.", "As can be appreciated, a patient can weigh himself/herself on the scale and then manually enter the data for use by the medical provider; however, this is not required.", "In one non-limiting arrangement, the weight must register no greater than 501 pound or some other upper limit; however, this is not required.", "Weights that are above the upper weight limit can be designed to create an error and request the patient to manually enter their weight, request the patient to try again to take a proper weight, and/or request the medical assistant to assist the patient related to the scale; however, this is not required.", "The scale can be positioned in any location in the medical kiosk (e.g., floor, bench, chair, etc.).", "A lower weight limit can also be used to create an error which requires the user to try again and obtain a proper weight.", "In one non-limiting embodiment, the scale can be integrated into the medical kiosk in such a way that it at least partially incorporated in on the floor of the medical kiosk.", "In one non-limiting design, the scale is positioned flush with the floor so that it poses no safety challenges for the user/patient in the medical kiosk; however, this is not required.", "As can be appreciated, the size, shape, and type of scale are non-limiting.", "The scale in the floor of the kiosk can also optionally be used as designated standing location of a patient so that a height of the patient can be obtained by use of one or more cameras and/or other electronic devices in the medical kiosk; however, this is not required.", "The blood pressure cuff, when used, is used to determine the arterial pressure of the systemic circulation.", "The blood pressure cuff can also be used to obtain the pulse rate of the patient.", "The information that is transmitted by the blood pressure cuff can be displayed on the Patient's Screen and/or Provider's Screen in the medical kiosk and/or on the screen being used by the medical provider; however, this is not required.", "The transmission of the signal from the scale can be by various means (e.g., hardwire, USB, Bluetooth, Wi-Fi, etc.).", "On the interior of the medical kiosk, the blood pressure cuff can be contained in the third medical device cabinet on the right in the medical kiosk, when a medical cabinet is used; however, this is not required.", "Alternatively, the blood pressure cuff can be kept with the medical attendant, when available, and the medical attendant then assists the patient in placing the blood pressure cuff on the patient prior to the patient entering the medical kiosk or while the patient is located in the medical kiosk; however, this is not required.", "The patient's blood pressure can be collected during the vitals capture process which is prior to the consultation with the medical provider; however, this is not required.", "If the medical provider wants the patient's blood pressure to be retaken or if the patient's blood pressure has not already been taken, the blood pressure cuff can be activated or reactivated by the medical provider via the Provider Application by the medical provider selecting the blood pressure cuff icon on the provider's screen; however, the blood pressure cuff can be activated by other or additional arrangements.", "In one non-limiting arrangement, when the medical provider via the Provider Application selects the blood pressure cuff icon on the provider's screen, the cabinet door in the medical kiosk for the blood pressure cuff opens (e.g., drops down, etc.)", "to enable the patient in the medical kiosk to access the blood pressure cuff if the blood process cuff is located in a medical device cabinet; however, this is not required.", "Alternatively, the selection of the blood pressure cuff results in information from the blood pressure cuff being sent to the medical provider.", "As can be appreciated, if the blood pressure cuff is not located in a medical cabinet, that patient can obtain the blood pressure cuff from the location in which blood pressure cuff currently exists (e.g., in the medical kiosk, next to the medical kiosk, etc.)", "or the medical assistant, when available, can provide the blood pressure cuff to the patient if the medical attendant is retaining the blood pressure cuff.", "In another non-limiting arrangement, the medical kiosk can optionally include an ambidextrous blood pressure cuff.", "The cuff arm can optionally be mounted to the desk top to enable the blood pressure cuff to be moved from side to side of the desk top; however, this is not required.", "Such movement of the blood pressure cuff enables the blood pressure cuff to be positioned so that the left arm or right arm of a user can be inserted into the blood pressure cuff when the user is facing the desk top.", "As can be appreciated, when a blood pressure cuff is included in the medical kiosk, it can be mounted and/or positioned in the medical kiosk in a variety of ways.", "Information to and from the blood pressure cuff, when used, can be transmitted by wire and/or wirelessly to one or more computers, processors, storage devices, etc.", "in the medical kiosk and/or to a location remote from the medical kiosk.", "The ambidextrous blood pressure cuff, when used, may be made of high-strength plastic or any other sufficiently rigid and/or strong material (e.g., metal, composite material, etc.).", "The cuff arm can be designed to be manually moved by the patient/user, be remotely moved by the medical provider and/or medical kiosk assistant, and/or be electronically moved by the patient/user.", "The blood pressure cuff can be designed to be activated/deactivated by the patient/user and/or remotely by the medical provider and/or medical kiosk assistant, or always be on.", "The medical provider can provide instructions to the patient on how to use the blood pressure cuff (e.g., The blood pressure cuff is most effective when the patient fully places their bicep in the cuff, with the palm of their hand facing the ceiling, etc.)", "and/or instructions for use of the blood pressure cuff can be provided on the Patient Screen and/or Provider Screen in the medical kiosk; however, this is not required.", "When the blood pressure cuff is selected, a video image can be designed to appear on the Provider Application (e.g., medical provider's screen) and/or the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk.", "If a video image option is available for display on the Provider Screen and/or Patient Screen that is located in the interior of the medical kiosk, the medical provider via the Provider Application can turn off such video image on the Provider Screen and/or Patient Screen; however, this is not required.", "The medical provider via the Provider Application can capture images and/or data generated by the blood pressure cuff and/or video camera in the medial kiosk for placement in the patient's file; however, this is not required.", "The medical provider via the Provider Application can optionally annotate an image once captured (e.g., use the paint brush and font icons to modify image, etc.)", "and/or show the captured image to the patient; however, this is not required.", "The medical provider via the Provider Application can start and/or stop the blood pressure operation; however, this is not required.", "As can be appreciated, the patient can start and/or stop the blood pressure operation; however, this is not required.", "The medical provider and/or patient can request assistance by the medical assistant related to the blood pressure cuff if so required.", "In another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a scheduling application that 1) enables a medical provider to input the day and time the medical provider is available to conduct a visit with a patient in a medical kiosk, 2) obtains or collects information on appointments that have been made by one or more patients at one or more medical kiosks, and 3) assigns a medical provider to a particular appointment that has been made at a particular medical kiosk; however, this is not required.", "The scheduling application can be designed to enable a patient to select a particular medical provider, gender of a medical provider, specialty of a medical provider, a medical provider that can speak a certain language, etc.", "; however, this is not required.", "The scheduling application can be designed to allow a medical provider to refuse an appointment with a particular patient; however, this is not required.", "If the medical provider refuses an appointment, the scheduling application can be designed to attempt to schedule a different appointment for the newly available time slot of the medical provider, or can block off such time and not reschedule a new appointment for such time period; however, this is not required.", "The scheduling application can be designed to select a medical provider for a particular appointment based on a set algorithm (e.g., available medical provider that has the largest time since last appointment, available medical provider that accepts patient's insurance, available medical provider that is located closest to home residence of patient, etc.)", "and/or by a random process.", "The scheduling application can be designed to attempt to select a new medical provider for a particular appointment if the originally selected medical provider is unable and/or unwilling to conduct a visit with a patient in the medical kiosk; however, this is not required.", "In still another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medication adherence application; however, this is not required.", "The medication adherence application can be designed to reduce medication errors.", "The medication adherence application can include a reminder for patients to take their medications and then optionally the system can automatically log when the patient takes their medication; however, this is not required.", "The medication adherence application can also include the ability to track a patient's compliance to taking their medication on time and/or provide automatic progress reports; however, this is not required.", "The medication adherence application can also include the ability to remind the patient to timely take medications (e.g., text reminder, email reminder, phone call reminder, twitter reminder, video conference reminder, etc.", "); however, this is not required.", "The medication adherence application can also include the ability to refer the patient to a pharmacist to answer any questions and/or for additional consultation; however, this is not required.", "Each user/patient utilizing the medical kiosk can be automatically enrolled in the e-script network, which network sends their prescriptions to the pharmacy of their choice; however, this is not required.", "The medication adherence application can be used to assist in improving patient outcomes and/or satisfaction.", "The medication adherence application of the present invention can be designed to be used on a screen in the medical kiosk, and/or on a computer screen and/or mobile device; however, this is not required.", "The medication adherence application of the present invention can be designed to generate a screen that includes one or more main buttons (e.g., 1) Speak to a ______ (e.g., Walgreens, CVS, Wal-Mart, etc.)", "Pharmacist now, 2) Change my medications alerts, 3) Learn about controlling my ______ (e.g., cholesterol, high blood pressure, diabetes, etc.", "), 4) Check orders status, 5) Refill Prescriptions, etc., 6) Transfer prescriptions to ______ (e.g., Walgreens, CVS, Wal-Mart, etc.", "), 7) Recommended dosage, 8) Period for taking medications, 9) Frequency for taking medications, 10) Information about medications, 11) Generic brands available for medications, 12) Request appointment to speak with a medical provider, 13) Entry of compliance information regarding medication usage by patient, etc.", "); however, this is not required.", "The screen can include additional buttons (e.g., help button, Finish button, etc.", "); however, this is not required.", "The screen can include advertising information; however, this is not required.", "The selection of one or more of the button can result in additional screens appearing based on the selected button; however, this is not required.", "If a user/patient needs further guidance from the pharmacist regarding the prescribed medication, the user/patient can select the first category button to request such information; however, this is not required.", "The patient/user can be provided a number to call and/or allow the user to send an email, make a phone call, etc.", "regarding the question.", "The user/patient can be provided the option to set a new appointment to meet with a medical provider regarding the medication; however, this is not required.", "The user/patient can be provided the option to change the medication alerts; however, this is not required.", "Such change can be requested by telephone, email, text, etc.", "The frequency and/or type of alert and/or the manner in which the alert is sent to the user/patient (e.g., email, twitter, phone message, text, etc.)", "may also be modified by the user/patient; however, this is not required.", "The user/patient may be provided the option to obtain information about certain medical conditions (e.g., cholesterol, blood pressure, migraines, back pain, arthritis, allergies, flu, etc.", "); however, this is not required.", "The user/patient may be provided the option to obtain the order status, shipment status, etc.", "for a particular medication; however, this is not required.", "If allowable by current medication guidelines and/or medical plans, the patient may request to fill their prescriptions directly through the application; however, this is not required.", "The user/patient may be provided the option to change their preferred prescription location; however, this is not required.", "The user/patient may be provided the option to enter information as to whether the prescribed medications are being timely taken and in the proper amounts; however, this is not required.", "Periodic reports regarding medication compliance can be generated and provided to the user/patient via phone, email, text, twitter, etc.", "; however, this is not required.", "The medication adherence application of the present invention can be used to allow the patient to more easily obtain and understand the correct usage of their prescriptions.", "In summary, the medication adherence software application allows a user/patient to 1) speak to a pharmacist, 2) change the patient's medications alerts, 3) learn about certain types of medical conditions, 4) check medication orders status, 5) check medication delivery status, 6) refill a prescriptions, 7) transfer prescriptions to a another location, 8) obtain information about recommended medication dosages, 9) obtain information about recommended times to take medications, 10) obtain information about recommended frequency for taking medications, 11) obtain information about medications, 12) obtain information about generic brands available for medications, 13) request an appointment to speak with a medical provider, 14) enter information regarding compliance information regarding medication usage by patient, and/or 15) receive compliance reports for patients regarding medication usage.", "In yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include an expandable mounting system for medical devices; however, this is not required.", "Such an arrangement is generally for kiosks other than personal medical kiosks; however, this is not required.", "In one non-limiting embodiment of the invention, the medical kiosk includes one or more equipment chambers that can be positioned on or near the front interior wall of the medical kiosk; however, it can be appreciated that one or more equipment chambers can be positioned in other or additional regions of the medical kiosk.", "The equipment chambers are used to store one or more medical devices (e.g., stethoscope, otoscope, thermometer, dermascope, spirometer, pulse oximeter, heating pad, magnifying glass, tongue depressor, tweezers, blood glucometer etc.).", "The one or more equipment chambers can also or alternatively be used to include other types of materials (e.g., tissue, Band-Aid, gauze, cotton ball, disinfecting wipe, cortisone cream, antibiotic cream/ointment, alcohol wipe, cotton swab, fabric wrap, etc.).", "The one or more equipment chambers generally include a door to limit access to the one or more equipment chambers; however, this is not required.", "The door, when used on one or more of the equipment chambers, can be manually openable/closeable, and/or the doors can be controllably opened/closed remotely by the medical provider and/or medical attendant.", "Generally, one or more of the doors are controllably opened and/or unlocked by the medical provider during the examination of the user in the medical kiosk; however, this is not required.", "After the user/patient has left the medical kiosk, the medical attendant, when available or used, can enter the medical kiosk, clean the medical equipment that was handled or used by the prior user/patient, and/or dispose of and/or replace items that were used and/or handled by the prior user/patient; however, this is not required.", "Thereafter, the medical attendant can restock, replace, and/or reposition the medical equipment and/or non-medical equipment in the equipment chambers and close the equipment chamber doors prior to the next user/patient entering the medical kiosk; however, this is not required.", "One or more types of medical equipment can be designed to transmit information by wire or wirelessly to electronic components in the medical kiosk and/or to the remotely located medical provider; however, this is not required.", "In one non-limiting arrangement, the medical kiosk can include six (6) equipment chambers (e.g., medical device cabinets, etc.)", "having doors, three on each side of the desk top of the medical kiosk.", "As can be appreciated, a larger or smaller number of equipment chambers can be used and/or the one or more equipment chambers can be positioned in other or additional locations in the medical kiosk.", "As also can be appreciated, some or all of the equipment chambers can be absent doors.", "The door on one or more of the equipment chambers can be designed to be unlocked and/or opened remotely by the medical provider and/or medical attendant; however, this is not required.", "The doors can be designed to automatically lock closed when the doors are closed by the medical attendant and/or medical provider after the user/patient has left the medical kiosk; however, this is not required.", "Each of the equipment chambers can be designed to include a different piece of medical equipment (e.g., stethoscope, otoscope, thermometer, dermascope, spirometer, and pulse oximeter); however, other or additional equipment and/or materials can be included in one or more of the equipment chambers (e.g., wipes, blood sugar analyzer, tissue, band aide, gauze, urine sample container, medication, defibrillator, blood pressure cuff, an audiometer to test hearing, a 3-lead EKG, a glucometer to measure blood glucose levels, etc.).", "Alternatively, the equipment chambers can be used to store one or more integrated medical devices that can include, but are not limited to, the following integrated devices: a stethoscope to evaluate heart, lung and/or bowel sounds; a thermometer to record temperature; an otoscope to examine the ear drum, external ear canal, nasal passages, mouth and/or throat; pulse oximeter to measure blood oxygen saturation and/or heart rate; a spirometer and transducer to measure the volume of air inspired and/or expired by the lungs; an audiometer to test hearing; a 3-lead EKG to provide a snapshot of the heart rhythm and/or data regarding stress and/or injury to the heart muscle; and/or a glucometer to measure blood glucose levels.", "As can be appreciated, other or additional medical devices can be included in the medical kiosk which are inside or outside of the expandable mounting system such as, but not limited to, a scale, lab-on-a-chip finger stick technology, blood analyzer (e.g., blood sugar analyzer, blood toxicity analyzer, blood oxygen content analyzer, etc.", "), height tape and others; however, this is not required.", "As can also be appreciated, a larger or smaller number of medical equipment can be used with and/or included in the medical kiosk and/or different types of medical equipment can be used with and/or included in the medical kiosk.", "The one or more equipment chambers can also or alternatively be used to include other types of material (e.g., tissue, gauze, disinfecting wipe, cotton ball, tongue depressor, tweezers, cortisone cream, urine sample container, etc.", "); however, this is not required.", "The one or more equipment chambers generally include a door to limit access to the one or more equipment chambers; however, this is not required.", "The door, when used, can be manually openable/closeable, and/or the doors can be controllably open/closed remotely by the medical provider or medical attendant; however, this is not required.", "The expandable mounting system for medical devices can be made of high-strength plastic or any other sufficiently rigid and strong material such as metal, wood, and the like.", "The configuration and/or size of each the equipment chambers can be the same or different.", "The one or more doors on the expandable mounting system can be manually opened and/or closed and/or remotely opened and/or closed by a medical provider and/or medical attendant.", "The one or more medical devices in the one or more chambers or bays can be activated/deactivated remotely by software and/or manually activated/deactivated.", "The one or more medical devices in the one or more chambers or bays can be connected to a connector in the chambers or bays so as to supply power to the medical device and/or to electronically transmit information between the medical device and a computer, network, storage device, etc.", "The expandable mounting system can include one or more visual indicators (e.g., light, etc.)", "to indicate to a user/patient which chamber is to be used and/or is active.", "A medical attendant and/or medical provider can be used to assist the patient in the operation of one or more medical devices; however, this is not required.", "In still yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include digital signage on the exterior of the medical kiosk; however, this is not required.", "Generally, the personal medical kiosk does not include digital signage; however, this is not required.", "The medical kiosk can include advertisements that are displayed on the display; however, this is not required.", "The digital signage, when used, can be displayed through one or more monitors or display screens on the exterior and/or interior of the medical kiosk to able a user/patient/potential user to see one or more of the monitors or display screens.", "One non-limiting aspect of this invention is that the one or more monitors or display screens can be used to display advertisements that may be arranged by the originating site; however, this is not required.", "Another non-limiting aspect of this invention is that one or more of the monitors or display screens can be used to display the current wait time for the medical kiosk and/or the list of scheduled appointments; however, this is not required.", "The digital signage application can allow various companies to advertise via the medical kiosk, including the business where it is located; however, this is not required.", "The digital signage application can be tailored to display information for specific patients based upon their conditions; however, this is not required.", "The digital signage application can include the ability to display a scrolling message at the bottom of the screen, based upon the business's preference; however, this is not required.", "The one or more display screens and/or monitors can be used to provide various types of information (e.g., registration information, information input by the user, advertising information, information about the medical kiosk, information about wait time for a medical kiosk, information as to the order of users waiting to use the medical kiosk, information about whether a medical kiosk is available or in use, cable TV, satellite TV, local broadcast TV, infomercial, medical programs, DVD materials, Blu-ray materials, etc.).", "Patients waiting to enter the medical kiosk can be allowed to view the various advertisements and/or other types of information displayed on the one or more screens; however, this is not required.", "The patients can see the wait time for their appointment and/or their position in the appointment queue when such information is displayed on the one or more video screens; however, this is not required.", "Any message necessary for the patient to see can also be displayed upon the screen in the interior of the medical kiosk; however, this is not required (e.g., “Welcome (Patient Name)”, “Your Medical Provider (Provider Name) Will Begin Your Visit Once You Have First Captured Some Basic Vitals”, etc.).", "The one or more interior screens are primarily utilized for video conferencing between the patient and the provider, patient data input, and patient instructions, but can also be used to display advertisements and/or other information during periods where the medical kiosk has no appointment queued; however, this is not required.", "The digital signage application can allow businesses to display advertisements and/or current promotions in a way that will attract the consumer's attention; however, this is not required.", "The ability to tailor the signage to individual patients and/or population groups makes it very adaptable; however, this is not required.", "The information on the display can be in any language.", "The information on the display can include subtitles, etc.", "; however, this is not required.", "In another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include an exterior check-in registration station via an integrated touch screen monitor; however, this is not required.", "The personal medical kiosk generally does not include the use of an exterior check-in registration station.", "The novel method of the present invention can include the use of a medical kiosk to enable the patient to conveniently communicate with the medical provider.", "In one non-limiting embodiment, the medical kiosk has an exterior check-in registration station.", "The check-in registration station can include a key pad and/or key board for identification and/or data entry, a touch screen for identification and/or data entry, microphone and/or voice recognition software for identification and/or data entry, fingerprint scanner for identification and/or data entry, and/or retina scanner for identification and/or entry; however, this is not required.", "As can be appreciated, other or additional devices can be included on the medical kiosk for identification and/or data entry.", "The medical kiosk having an exterior check-in registration station can be used by the patient to enter/convey basic information about the patient.", "Such information includes, but is not limited to, a) patient name, b) patient address, c) patient contact information, d) patient age, e) patient sex, f) patient height, g) patient weight, h) patient medical history, i) current medicines used by patient, j) reason(s) for visit by patient, k) patient current symptoms, l) patient insurance information, m) patient payment information, n) consent forms, and/or o) patient's current doctor.", "As can be appreciated, other or additional information can be input/conveyed by the patient.", "The medial kiosk can be designed to provide information to the patient prior to and/or during the inputting/conveying of information by the patient to the medical kiosk.", "In one non-limiting embodiment of the invention, the medical kiosk can include audio and/or visual instructions and/or displays used to provide a) information about the medical kiosk, b) how to use the medical kiosk, c) how to properly input/convey information to the medical kiosk, d) provide instructions and/or interactions with the patient during the inputting/conveying of information by the patient to the medical kiosk, e) the wait time for the patient's use of the medical kiosk, f) a list of patient's waiting to use the medical kiosk, g) the types of conditions that can be treated by the medical kiosk, h) the type of medical devices that can be used with the medical kiosk, i) how to use medical devices with the medical kiosk, j) information about who is qualified to use the medical kiosk, and/or k) information regarding whether the medical kiosk is in use or is available.", "In another and/or alternative non-limiting embodiment of the invention, the medical kiosk can include light and/or sound indicators to provide information regarding 1) whether the medical kiosk is in use or is available, 2) whether information is required to be entered and/or is improperly entered and/or correctly entered in the medical kiosk, and/or 3) whether a medical device is properly or improperly connected to the medical kiosk; however, this is not required.", "In still another and/or alternative non-limiting embodiment of the invention, the medical kiosk can include a notification system to a patient that the medical kiosk is available or will soon be available; however, this is not required.", "Such notification can be sent via email, phone, pager, internet, etc.", "Such notification system can be useful when the medical kiosk is not currently available to the patient.", "The patient can input the information into the medical kiosk and then go home, run other errands, etc., and then be later notified when the medical kiosk is available or will soon be available.", "The medical kiosk and/or notification system can also be used to inform the patient when and/or where other medical kiosks are available; however, this is not required.", "This service, when available, can be used to inform the patient that a nearby medical kiosk has a shorter wait period or is currently available, thus providing the patient with the option of traveling to another available medical kiosk instead of waiting for the current medical kiosk to become available; however, this is not required.", "This service, when available, can also be used to inform the patient when a prescription is ready for pickup and/or for conveying prescription information to the patient; however, this is not required.", "This service, when available, can also be used to inform the patient when a follow-up visit is due and/or scheduled; however, this is not required.", "As can be appreciated, the notification system can be used to provide information to patients about medication, medication compliance, when medication should be taken, or for other or additional services.", "The medical kiosk can include an exterior registration station for check-in via a touch-screen monitor (e.g., monitor, etc.).", "The exterior registration station is typically not used with a personal medical kiosk.", "The monitor or touch-screen monitor of the exterior registration station can be mounted at a height and angle that meets ADA compliance and is easily accessible to individuals in wheel chairs; however, this is not required.", "The touch screen monitor can include a built-in privacy filter for HIPAA compliance; however, this is not required.", "In one non-limiting embodiment, the front panel of the medical kiosk includes a registration station.", "The registration station can include a touch screen, a display screen, and an optional frame that such components can be mounted thereto; however, this is not required.", "The shape of the frame, when used, is non-limiting.", "The frame, when used, can be designed to be easily removed from the front panel to enable servicing, repair, replacement, etc.", "of one or more components of the registration station; however, this is not required.", "As can be appreciated, the registration station can also or alternatively include other or optional features (e.g., additional display screen, additional touch screen, lights, buttons, switches, camera, speakers, microphone, keyboard, scanner, receiver, transmitter, credit card/debit card or other some other card reader, smart phone or other smart device reader/scanner, finger and/or eye scanner, shelf, printer, storage cavity, service access door, motion sensor, sound sensor, temperature sensor, logos, etc.", "); however, this is not required.", "The touch screen, when used, is generally used to allow a user to enter in information about the user (e.g., age, sex, contact information, payment information, medical history, medical issue, etc.", "); however, this is not required.", "The touch screen can be substituted for a keyboard; however, this not required.", "The frame can be designed to mount the touch screen at some angle (e.g., 10-80) relative to the front plane of the front panel; however, this is not required.", "The frame optionally includes one or more side sections that can include one or more other or optional features of the registration station; however, this is not required.", "As can be appreciated, one or more other or optional features of the registration station can also or alternatively be located on other regions of the registration station.", "The touch screen can display various types of information (e.g., electronic keyboard, instructions on how to register, questions that are displayed during registration, instructions during registration, information displayed to user during registration, various templates, various menus, various lists of information, etc.", "); however, this is not required.", "As can be appreciated, the medical kiosk can be designed to accept voice commands during the registration process; however, this is not required.", "The display screen can be used to provide various types of information (e.g., registration information, information input by the user, advertising information, information about the medical kiosk, information about wait time for a medical kiosk, information as to the order of users waiting to use the medical kiosk, information about whether a medical kiosk is available or in use, cable TV, satellite TV, local broadcast TV, infomercial, medical programs, DVD materials, Blu-ray materials, etc.).", "Another display screen can be positioned above the screen used at the registration station and/or at some other location on the exterior of the medical kiosk; however, this is not required.", "This other display screen can be used to display various types of information (e.g., advertising information, information about the medical kiosk, information about wait time for a medical kiosk, information as to the order of users waiting to use the medical kiosk, information about whether a medical kiosk is available or in use, cable TV, satellite TV, local broadcast TV, infomercial, medical programs, DVD materials, Blu-ray materials, etc.", "); however, this is not required.", "In one non-limiting arrangement, the screen used at the registration station and the one or more other displays can be designed to display different types of information (e.g., screen used at the registration station displays information related to the registration process and the one or more other displays are used to display one or more types of information that are different from the information displayed on the screen used at the registration station, etc.", "); however, this is not required.", "The size of the screen used at the registration station and the one or more other displays can be the same or different.", "In one non-limiting arrangement, a user/patient can be allowed to enter payment information at the registration station (e.g., swipes a credit or debit card, etc.", "); however, it can be appreciated that payment information can also or alternatively be entered inside the medical kiosk, at the optional attendant station, wirelessly or over a network via a smart phone or other device or by a computer connected to a network, etc.", "If a medical attendant is available, the medical attendant can assist a user during the registration process; however, this is not required.", "Generally, the medical kiosk includes a single registration station; however, this is not required.", "As can be appreciated, the registration station can alternatively be located inside the medical kiosk, at the attendant station, on other panels or sidewalls of the medical kiosk, or located remotely from the medical kiosk (e.g., central registration center for use with multiple medical kiosks, etc.).", "In one non-limiting arrangement, the exterior check-in registration station can be designed to be easily removed from the front panel of the medical kiosk and/or be easily accessed from the interior of the medical kiosk to enable servicing, repair, replacement, etc.", "of one or more components of the registration station; however, this is not required.", "The check-in system in accordance with the present invention offers a new way for organizations to meet rising consumer expectations for convenience and, at the same time, improve accuracy and usability of information systems; however, this is not required.", "The check-in system in accordance with the present invention can result in shorter waiting times for check-in, as well as efficiency gains from increased throughput and fewer errors in keeping patient demographic data up to date; however, this is not required.", "The check-in system in accordance with the present invention can result in the reduction of risk of patient misidentification and clerical errors at data entry; however, this is not required.", "The check-in system in accordance with the present invention can improve accuracy in language access for those not fluent in English by offering multiple language options during the check-in process; however, this is not required.", "In still another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a sanitizing system (e.g., UV system, mist system, etc.)", "that can be automatically activated and/or activated by the medical attendant, when used, and/or medical provider prior to and/or after a patient has used the medical kiosk; however, this is not required.", "The personal medical kiosk generally does not include a sanitation system; however, this is not required.", "The medical kiosk can include a cleaning system designed to clean the interior of the medical kiosk and/or kill/neutralize some of or all germs and/or other microorganisms in the medical kiosk (e.g., air in the medical kiosk, one or more surfaces of the medical kiosk, one or more medical devices, etc.", "); however, this is not required.", "One non-limiting cleaning system that can be used is an ultraviolet sanitizing system.", "As can also be appreciated, a mist sanitizer can also or alternatively be used to fully or partially clean/sanitize one or more portions of the medical kiosk.", "As can be appreciated, other or additional cleaning systems can be used.", "In another and/or alternative non-limiting aspect of the invention, the medical kiosk can be made of one or more materials that resist growth of bacteria, viruses and/or other microorganisms; however, this is not required.", "In one non-limiting embodiment, the floor, walls and ceiling of the medical kiosk include or are fully made of materials that resist or prevent the growth of bacteria, viruses and/or other microorganisms; however, this is not required.", "In one non-limiting arrangement, the medical kiosk includes an ultraviolet light sanitization system which can be used in the medical kiosk and which can be activated through software from a remote location and/or by a kiosk attendant; however, this is not required.", "The ultraviolet light sanitization system can be activated twice daily to ensure the sanitary environment is maintained; however, it can be appreciated, that the ultraviolet light sanitization system can be activated a greater or lesser number of times per day.", "The location of the ultraviolet light sanitization system, when used, is non-limiting.", "In one non-limiting arrangement, the ultraviolet light sanitization system can be located in the roof or ceiling of the medical kiosk; however, this is not required.", "For example, the ultraviolet light sanitization system can be connected or positioned adjacent to the ceiling panel and rear panels; however, this is not required.", "The ultraviolet light sanitization system can be located in the rear of the medical kiosk where it will be out of the way of the patients utilizing the medical kiosk; however, this is not required.", "The ultraviolet light sanitizing system generally includes one or more ultraviolet lights that are designed to kill some or all of the germs and/or other microorganisms in the medical kiosk (e.g., air in the medical kiosk, one or more surfaces of the medical kiosk, one or more medical devices, etc.).", "The ultraviolet sanitizing system can optionally include one or more vents that allow air to flow into and/or out of the ultraviolet sanitizing system to facilitate in the cooling of the ultraviolet sanitizing system; however, this is not required.", "The sanitization system can be built with high-strength plastics and/or any other sufficiently rigid and strong material such as metal and constructed in a way preventing it from being tampered with by patients or anyone other than the attendant; however, this is not required.", "Such an arrangement, when used, can facilitate in ensuring that it is not activated incorrectly or at an inopportune time; however, this is not required.", "The shape, size and/or configuration of the built in sanitization system are non-limiting.", "The one or more medical attendants, when used, can also or alternatively clean and/or sanitize various regions of the medical kiosk prior to and/or after being used by a patient and/or set up the medical kiosk for a new user; however, this is not required.", "For example, prior to and/or after one or more patients have entered the medical kiosk, the one or more attendants can clean/sanitize one or more exterior surfaces and/or regions of the medical kiosk (e.g., medical kiosk door, medical kiosk check-in terminal, medical kiosk desk top, medical kiosk exterior walls, medical kiosk touch screen, medical kiosk monitors, seating/tables in waiting area near medical kiosk, etc.", "); however, this is not required.", "In an another and/or additional example, prior to and/or after one or more patients have entered the medical kiosk, the one or more medical attendants, when used, can clean/sanitize one or more interior surfaces of the medical kiosk (e.g., medical kiosk door, medical kiosk floor, medical kiosk bench, medical kiosk chair, medical kiosk user terminal, medical kiosk interior desk top, medical kiosk interior walls, medical kiosk touch screen, medical kiosk monitors, medical kiosk instrument doors, medical devices/instruments used by and/or touched by user when in the medical kiosk, any other surface in the interior of the medical kiosk, etc.", "); however, this is not required.", "For a personal medical kiosk, the patient can generally clean/sanitize the personal medical kiosk and/or medical devices prior to, during and/or after use of the personal medical kiosk.", "In still another and/or additional example, prior to and/or after one or more patients have entered the medical kiosk, the one or more medical attendants, when used, can set up the medical kiosk for a user (e.g., clean/sanitize interior surfaces of medical kiosk; clean/sanitize medical devices/instruments used and/or touched by a prior user; reposition medical devices/instruments into device storage areas; replace disposable components on medical devices/instruments; fix, repair and/or replace fans, UV bulbs, UV devices, etc.", "in the interior and/or exterior of the medical kiosk; refill cleaning and/or sanitizing fluid; etc.", "); however, this is not required.", "In still yet another and/or alternative non-limiting aspect of the invention, the medical kiosk can include a sanitizing system (e.g., UV system, mist system, etc.)", "that can be automatically activated and/or activated by the medical attendant, when used, prior to and/or after a patient has used the medical kiosk; however, this is not required.", "As can also be appreciated, a mist sanitizer can also or alternatively be used to fully or partially clean/sanitize one or more portions of the medical kiosk and/or medical devices.", "Generally, the germs and/or other microorganisms in the medical kiosk are treated when the interior of the medical kiosk does not include a user.", "The sanitizing system can optionally include one or more standard lights that can be used to provide illumination in the medical kiosk; however, this is not required.", "The sanitizing system can optionally include a cooling fan for the one or more components in the sanitation system; however, this is not required.", "The sanitizing system can optionally include both a UV and a mist sanitizing system; however, this is not required.", "The sanitizing system can house one or more cameras, speakers, sensors (e.g., temperature sensor, motion sensor, sound sensor, etc.", "), etc.", "for use in the medical kiosk; however, this is not required.", "The sanitizing system includes a shroud that includes vent/light/mist openings to house the components of the sanitizing system; however, this is not required.", "The shape, size and configuration of the shroud, when used, are non-limiting.", "When a mist sanitizing system is additionally or alternatively used, one or more mist nozzles can be located in one or more regions of the medical kiosk so as to direct the sanitizing mist to desired locations in the medical kiosk (e.g., onto certain surfaces of the medical kiosk, onto certain medical devices, etc.", "); however, this is not required.", "The doors to the medical kiosk can be closed and/or locked to prevent a user/patent from entering the medical kiosk during a sanitizing process; however, this is not required.", "In yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medical kiosk that enables a service operator to easily access the various components of the medical kiosk for purposes of service, repair, maintenance, upgrade, replacement, etc.", "; however, this is not required In order to offer the comprehensive services the medical kiosk is capable of, there are multiple components that must be functioning at all times; however, this is not required.", "The various devices that may need service include, but are not limited to, the display screens, the network connection, various other electronics and wiring, fans, lights, electronic switches, backup power supplies, computers, electronic storage devices, doors on the medical equipment compartments, etc.", "The ability to easily and conveniently access and/or perform maintenance on these components is advantageous to providing the medical kiosk services via the medical kiosk; however, this is not required.", "To more easily facilitate the service of these components, the medical kiosk can be designed with a moveable front panel; however, this is not required.", "The front panel can be built on casters, wheel, rail system, etc.", "to allow the front panel to be easily moved; however this is not required.", "Such an arrangement is generally not used with a personal medical kiosk; however, this is not required.", "The front panel can be equipped with a tamper-proof lock to prevent unauthorized personnel from accessing the components located behind the front panel; however, this is not required.", "A portion of or the entire front panel can be designed to move in order to ensure that when there is a problem with one or more components used in the medical kiosk, the repair of such components does not require the disassembly of the entire or a substantial portion of the medial kiosk to repair the components; however, this is not required.", "The components of the medical kiosk that are generally difficult or inaccessible when the medical kiosk is fully assemble are 1) the components that form the exterior check-in station, 2) the interior displays or monitors, 3) the interior speakers, the interior cameras, 4) the interior sound jack, 5) the doors on the medical compartments, 6) the interior microphone, 7) the electronics located behind the exterior check-in station, 8) the electronics located behind the interior AV system, and/or 9) the computer and other electronics used for network communication, control and/or storage; however, this is not required.", "As can be appreciated, there may be other or additional components of the medical kiosk that are generally difficult or inaccessible when the medical kiosk is fully assembled.", "Access to one or more of these components can be more easily accessed by the movement of the interior front panel of the medical kiosk; however, this is not required.", "In still yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a method and a medical kiosk that enables the medical provider to generate electronic prescriptions and/or for the patient to conveniently select and/or order prescription drugs; however, this is not required.", "In one non-limiting embodiment, this novel method and apparatus will allow patients to 1) choose between name brand and generic drugs, 2) choose the supply quantity for the prescription (i.e., 30 days supply, 60 days supply, 90 days supply, etc.", "), 3) choose between picking up the prescription at the pharmacy of their choice or mail delivery of the prescription, 4) enter medical insurance for partial or full payment of the prescription, 5) enter a credit or debit card information to pay for the prescription, 6) enter information for mail delivery of the prescription, 8) enter information to provide automatic reminders to patient regarding refills and/or follow-up medical visits, 9) enter information to enable a patient to be notified when a prescription has been mailed and/or is ready to be picked up at the pharmacy; however, this is not required, 10) obtain a print out and/or electronic version of the prescription written by the medical provider, and/or 11) receive information about the issued prescription (e.g., prescribed use, side effects, etc.)", "in printout and/or electronic form; however, this is not required.", "Another non-limiting aspect of this method and apparatus will allow the patient to select the pharmacy where he/she would like to pick up the prescription; however, this is not required.", "In one non-limiting embodiment of the invention, the medical provider can generate an electronic prescription for a patient.", "The prescription can include both the generic and name brand drugs along with the patient copay amount for each; however, this is not required.", "The electronic prescription can provide additional information (e.g., potential savings for selecting certain medications, the dosage amount, the medication dosage, quantity or strength, name of medical provider, help information, coupons, advertising information, etc.", "); however, this is not required.", "Once the particular medication brand is selected by the patient, another screen can optionally appear; however, this is not required.", "For example, the second screen can illustrate the brand of medication selected by the patient/user and/or also provide quantity supply options for the medication, etc.", "; however, this is not required.", "The second screen can optionally illustrate additional information such as, but not limited to, the copay amount for the selected medication brand and quantity, the monthly, yearly, etc.", "savings for selecting a particular medication brand and/or quantity, help information, go back option, advertising information, coupons, generic options for medication, etc.", "; however, this is not required.", "The second or a third screen can optionally appear that provides an order confirmation along with the associated savings; however, this is not required.", "The second or third screen can optionally illustrate additional information such as, but not limited to, the monthly, yearly, etc.", "savings for selecting a particular medication brand and/or quantity, help information, advertising information, etc.", "As can be appreciated, other or additional screens can be displayed to the user/patient.", "This aspect of the invention has the advantage of allowing the user/patient to view and/or select brand or generic drugs, thereby allowing the user/patient to decide which drug option is best for them and their budget; however, this is not required.", "The medical kiosk and method for using the medical kiosk can thus include a point of purchase prescription workflow application allowing a medical provider to generate prescriptions and optionally allowing patients to select and/or order prescription drugs; however, this is not required.", "The medical kiosk and method for using the medical kiosk can include a point of purchase prescription workflow application that allows a user/patient to choose his/her drug brand and/or quantity; however, this is not required.", "The medical kiosk and method for using the medical kiosk can include a point of purchase prescription workflow application that allows a user/patient to select the pharmacy from which to pick up his/her prescription; however, this is not required.", "In another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include headphone jacks; however, this is not required.", "The one or more headphone jacks allow for hearing-impaired patients to utilize headphones in order to better understand the provider's instructions; however, this is not required.", "The one or more headphone jacks can also be used to enable additional persons in the medical kiosk (e.g., child's parent, etc,) to listen in on the conversation between the medical provider and patient; however, this is not required.", "The one or more headphone jacks can also be used to provide additional privacy between the medical provider and patient; however, this is not required.", "The headphones may be available from the kiosk and/or the medical attendant; however, this is not required.", "The headphone jack can be placed at a height allowing any person to reach it if necessary; however, this is not required.", "The headphones generally will be sanitary either through disposable covers or through another form of sanitization; however, this is not required.", "The headphone jack can be a standard jack to enable a patient to use his/her own headphone; however, this is not required.", "The medical kiosk can include a wireless system (e.g., Bluetooth technology, IR technology, RF technology, etc.)", "to transmit sound wirelessly to a patient and/or other person located in the medical kiosk; however, this is not required.", "The kiosk can also be equipped with a wheelchair accessible ramp; however, this is not required.", "The medical kiosk can be designed to be fully ADA compliant as a result of these novel innovations; however, this is not required.", "A medical kiosk that includes one or more headphone jacks and/or a wheelchair accessible ramp can permit the medical kiosk to better serve the public at large; however, this is not required.", "In still another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medical kiosk that utilizes high definition video and/or high quality sound to create a conference link between a patient located in the medical kiosk and a medical provider that is located remotely to the medical kiosk; however, this is not required.", "In one non-limiting aspect of the invention, the medical kiosk includes the use of one or more high definition cameras, one or more high definition monitor(s) and/or high quality speaker(s) built into the medical kiosk and/or used with the medical kiosk; however, this is not required.", "The one or more cameras located on, near, or within the medical kiosk can be on an adjustable sliding bar allowing camera positioning to create ideal eye contact; however, this is not required.", "The one or more cameras in the medical kiosk can be used to enable a medical provider to obtain information about a user/patient in the medical kiosk (e.g., height, build, sex, skin color, alertness, body cuts, body infections, body rashes, pupil dilation, hygiene, race, physical condition, emotional condition, metal condition, etc.", "); however, this is not required.", "In one non-limiting arrangement, one or more monitors and/or display screens can be positioned on the front interior wall of the medical kiosk; however, this is not required.", "The monitor is generally used to view the one or more medical providers when the user/patient is located in the medical kiosk; however, this is not required.", "The shape, size, and thickness of the one or more monitors are non-limiting.", "One or more cameras can be positioned on the front interior wall, be embedded in the one or more monitor/display screens, and/or be located on a sliding bar allowing it to be positioned relative to the user/patient to create better eye contact with the user/patient in the medical kiosk; however, it can be appreciated that the one or more cameras can be located in other locations.", "The one or more cameras enable pictures of the user/patient in the medical kiosk to be transmitted to a remotely located medical provider; however, this is not required.", "The remotely located provider typically has a camera at his/her location so that pictures of the medical provider can be transmitted to the one or more medical screens in the medical kiosk; however, this is not required.", "As can be appreciated, a projector can be used as a substitute of one or more monitors in the medical kiosk; however, this is not required.", "One or more speakers can be positioned on the front interior wall of the medical kiosk; however, this is not required.", "As can be appreciated, one or more speakers can be positioned on other or additional locations in the medical kiosk; however, this is not required.", "The speakers can be used to enable a user/patient in the medical kiosk to listen to what the medical provider is saying to the user/patient; however, this is not required.", "One or more microphones are generally included in the medical kiosk to allow the user/patient to communicate with the medical provider; however, this is not required.", "In yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medical kiosk that is a modular kiosk that is able to be partially or fully broken down; however, this is not required.", "In one non-limiting embodiment of the invention, the modular medical kiosk can be partially or fully broken down so as to fit through a doorway (e.g., standard 36″ by 80″ doorway, etc.", "); however, this is not required.", "The modular design of the medical kiosk, when the medical kiosk has a modular design, can enable the medical kiosk to be set up in various configurations to enable the medical kiosk to be used in various types of spaces; however, this is not required.", "The modular design of the medical kiosk can be designed to not only accommodate multiple configurations of the medical kiosk, but can also be designed to facilitate in enabling the medical kiosk to be moved into an existing facility and then allowing the assembly of the medical kiosk in such facility without having to modifying the entry ways into or out of the facility; however, this is not required.", "The medical kiosk can be formed of any number of materials (e.g., plastic, foam, metal, wood, etc.).", "The modular configuration of the medical kiosk can be such that it can be easily assembled and disassembled so that the medical kiosk can be easily brought into a location and easily set up; however, this is not required.", "The medical kiosk can be designed to include a floor panel; however, this is not required.", "The floor panel, when used, is generally a one-piece unit; however, the floor panel can be formed of multiple pieces.", "The floor panel, when used, can be formed of a durable material (e.g., plastic, metal, wood, composite material, man-made materials, etc.).", "The floor panel, when used, can be formed of a slightly compressible material to facilitate in the comfort of walking on the floor panel; however, this is not required.", "The floor panel can have an oval shape; however, other shapes can be used (e.g., circular, square, rectangular, polygonal, etc.).", "In one non-limiting design, the maximum length of the floor panel is generally 3-15 feet, typically 4-12 feet, more typically about 6-10 feet, and even more typically about 8-9 feet; however, other lengths can be used.", "In one non-limiting design, the maximum width of the floor panel is generally 3-10 feet, typically 4-8 feet, and more typically about 4-6 feet; however; other widths can be used.", "In one non-limiting design, the top surface area of the floor panel is generally 10-150 sq.", "ft., typically 15-80 sq.", "ft., and more typically about 50-60 sq.", "ft.; however, other surface areas of the floor panel can be used.", "The floor panel can be sized to enable a user in a wheelchair to enter the medical kiosk and turn and/or fully maneuver in the medical kiosk while sitting in the wheelchair; however, this is not required.", "In one non-limiting design, the thickness of the floor panel is generally about 0.1-5 inches, and typically about 0.25-3 inches; however, other thicknesses of the floor panel can be used.", "A ramp can be optionally used to facilitate the entry and exiting of the medical kiosk; however, this is not required.", "The shape and size of the ramp are non-limiting.", "The ramp can be made of a similar material as the floor panel; however, this is not required.", "The ramp generally includes a sloped surface to facilitate in transitioning from a floor surface to the top surface of the floor panel; however, this is not required.", "The medical kiosk can optionally include one or more benches, stools and/or chairs.", "When a bench is included in the medical kiosk, the bench is generally positioned on the back interior wall of the medical kiosk; however, this is not required.", "The bench can be used to allow a parent, guardian, spouse, relative, friend, etc.", "to sit in the medical kiosk while the user is obtaining medical services in the medical kiosk.", "The bench can be designed to enable one or more persons to sit on the bench.", "The bench can optionally include a storage space under the seat of the bench that can be used to store supplies, equipment, etc.", "for the medical kiosk.", "A liftable seat section can be used to access the storage space; however, this is not required.", "When the bench includes a storage space, the bench can include a lock to limit access to the storage space; however, this is not required.", "As can be appreciated, the medical kiosk can include one or more chairs (not shown) to enable one or more users to sit in the medical kiosk while receiving medical services in the medical kiosk; however, this is not required.", "The bench is generally about 10-25 inches high, and typically about 16-20 inches high; however, other heights can be used.", "In one non-limiting arrangement, the medical kiosk can include two front panels, two rear panels, one side wall, and one door system; however, this is not required.", "The front panels, rear panels, side wall, and door system are generally formed of a durable material (e.g., plastic, metal, wood, composite material, man-made materials, etc.).", "As can be appreciated, the medical kiosk can be designed to only include a single front panel and/or a single rear panel.", "As can also be appreciated, the medical kiosk can be designed to include more than two front panels and/or more than two rear panels.", "As can be appreciated, the medical kiosk can be designed to include more than one side wall and/or more than one door system.", "As can also be appreciated, a side wall can be substituted for another door system; however, this is not required.", "The general shape and size of the front and rear panels are the same; however, this is not required.", "The shape of the front and rear panels can be arcuate; however, this is not required.", "The radius of curvature the front and rear panels can be about 10-100 inches, typically 15-50 inches, and more typically about 20-35 inches; however, other radius of curvatures can be used.", "The front and rear panels can have an angle of curvature of about 90° or a quarter of a circle; however, it can be appreciated that one or both rear and/or front panels can have different angles of curvature.", "The general shape and size of the side wall and the door system are generally the same; however, this is not required.", "The side wall and door system can lie in a generally flat plane; however, this is not required.", "The front and rear panels and the side wall and door system can form a generally oval shape for the medical kiosk; however, this is not required.", "The two front panels and two rear panels can have the same or similar footprint; however, this is not required.", "The side wall and the door system can have the same or similar footprint; however, this is not required.", "The similarity in the shape and footprint of the wall components of the medical kiosk, when used, enables the medical kiosk to be assembled in a manner that is convenient for the facility that will include the medical kiosk.", "For example, if the door system needs to be positioned on the left side of the medical kiosk, instead of the right side, the similarly shaped side wall and door system enables the medical kiosk to be assembled in such a manner.", "Also, if the optional registration station of the medical system needs to be placed on the left side or right side or on the rear end of the medical kiosk instead of the front end, the similarly shaped front and rear panels can be easily exchanged to create such configuration for the medical kiosk.", "The modular medical kiosk not only accommodates multiple configurations of the medical kiosk, it also can facilitate in enabling the medical kiosk to be moved into an existing facility and then assembling the medical kiosk in such facility without having to modify the entryways into or out of the facility; however, this is not required.", "The thickness and height of the front panels, rear panels, side wall and door system are non-limiting.", "In one non-limiting embodiment, the maximum height of the front panels, rear panels, side wall and door system is about 5-12 ft., typically about 6-9 ft., and more typically about 7-8 ft.; however, other heights can be used.", "In one non-limiting embodiment, the thickness of the front panels, rear panels, side wall and door system is generally about 0.5-10 inches, typically about 1-5 inches, and more typically about 1-2 inches; however, other thicknesses can be used.", "The front panels, rear panels, side wall and door system can optionally include insulation, sound dampening material, etc.", "; however, this is not required.", "The front panels, rear panels, side wall and door system can be designed to be connected together in a variety of ways (e.g., bolted/screwed together, latched together, snap fitted together, press fitted together, etc.).", "Generally, the arrangement is used to connect together the front panels, rear panels, side wall and door system to enable easy connecting and disconnecting of the front panels, rear panels, side wall and door system from one another.", "One or more of the front panels, rear panels, side wall and door system can include openings, windows, transparent/semi-transparent regions that allow for ventilation, illumination, and/or viewing; however, this is not required.", "Generally, front panels, rear panels, side wall and door system are mostly or fully formed of opaque or non-transparent materials so as to ensure the privacy of the user in the medical kiosk; however, this is not required.", "The configuration of the door system is non-limiting.", "The door system can include a frame and two doors; however, it can be appreciated that the door system only includes a single door.", "Each door can include a handle or grasp cavity on one or both sides of the one or both doors.", "The one or more doors can be designed to open and close in a variety of ways (e.g., swing open and closed, slide open and closed on a top/bottom rail system, etc.).", "As can be appreciated, the one or more doors for the medical kiosk can also or alternatively be positioned on one or more of the front or rear panels; however, this is not required.", "In one non-limiting embodiment, the maximum height of the doors is generally about 5-9 ft., and typically about 6-7 ft.; however, other heights can be used.", "In one non-limiting embodiment, the maximum width of the entry provided by the one or more doors when fully open is generally about 15-60 inches, typically about 25-55 inches, and more typically about 30-50 inches; however, other widths can be used.", "The door opening is generally selected to enable a standard wheelchair to pass through the opening; however, this is not required.", "The medical kiosk can optionally include an exterior attendant station that is connected to and/or positioned near the medical kiosk.", "The exterior attendant station can be used by one or more medical attendants, medical providers, etc.", "A desk can be connected to and/or positioned next to an exterior wall of the medical kiosk; however, this is not required.", "The desk, when used, can be formed of one or more pieces.", "When the desk is designed to be connected to an exterior wall of the medical kiosk, such connection arrangement is not limited (e.g., screw, bolt, clamp, press fit, snap arrangement, etc.).", "The desk can include a desk top, one or more legs, one or more shelf regions, one or more drawers, etc.", "; however, this is not required.", "One or more chairs (not shown) can be used to allow one or more medical attendants, medical providers, etc.", "to sit at the desk; however, this is not required.", "The desk, when used, can be positioned at or adjacent to one or both front panels; however, this is not required.", "The desk can be designed to include one or more drawers, shelves, doors, etc.", "One or more locks can be included on the desk; however, this is not required.", "The desk can be used to support a monitor, computer, power supply, power strip, printer, router, network switcher, key board, mouse, printer paper, medical supplies, sanitation supplies, refrigerator, freezer, scanner, credit card/debit card reader, data port, lights, desk supplies, etc.", "The freezer and/or refrigerator, when used, can contain immunizations, medications, urine samples, blood samples, etc.", "In still yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medical kiosk that includes a ceiling panel; however, this is not required.", "The ceiling panel can be formed of one or more pieces.", "The ceiling panel can be formed of a transparent or semi-transparent material to allow light to enter and illuminate the interior of the medical kiosk; however, this is not required.", "In still yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medical kiosk that is made of one or more materials that resist or prevent the growth of bacteria, viruses and/or other microorganisms; however, this is not required.", "In one non-limiting embodiment, the floor, walls and ceiling of the medical kiosk include or are fully made of materials that resist or prevent the growth of bacteria, viruses and/or other microorganisms; however, this is not required.", "In still another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medical kiosk that includes a payment center that enables a user to pay for medical services, prescriptions, medical equipment, medical accessories, etc.", "prior to and/or after the user uses the medical kiosk; however, this is not required.", "The payment center can be in any form (e.g., credit card reader, mobile phone scanner, transmitter/receiver device, electronic scanner, cash receiver, etc.).", "The payment center may include a touch pad, keyboard, scanner, receiver, transmitter, credit card/debit card or some other card reader, smart phone or other smart device reader/scanner, finger and/or eye scanner, monitor, chair, table, shelf, printer, instructions on how to use the payment center, etc.", "The payment center can be located on the exterior and/or interior of the medical kiosk.", "Generally, the user is required to register and pay for the medical services prior to obtaining medical services from the medical provider; however, this is not required.", "In one non-limiting arrangement, the medical kiosk includes a registration station on the exterior of the medical kiosk (e.g., exterior wall of the medical kiosk, on a table exterior to the medical kiosk, etc.", "); however, this is not required.", "As can be appreciated, a user can be allowed to wirelessly connect to the medical kiosk or to some other computer network so as to wirelessly register and/or enter payment information for use of the medical kiosk; however, this is not required.", "In such an arrangement, a user could register to use a medical kiosk, enter in payment for use of the medical kiosk, set an appointment time for use of the medical kiosk, select a particular medical kiosk to use at some particular location, etc.", "at some location near or remote from the medical kiosk via a smart phone or other smart device, a computer, etc.", "In yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medical kiosk that includes an interior cavity or room that provides privacy to the patient when inputting and/or conveying data to the medical kiosk, and/or communicating with a medical provider via an audio and/or video link; however, this is not required.", "The size, configuration and/or arrangement of the interior cavity or room are non-limiting.", "The interior cavity or room can include a) one or more speakers, b) one or more microphones, c) one or more video displays, d) one or more data input device, e) one or more chairs and/or other types of seating areas, f) one or more tables, g) one or more doors, h) one or more shelves, i) one or more compartments used to contain medical supplies, medical instruments, etc., j) one or more light switches, k) one or more power outlets, l) sterilization system, m) one or more headphone jacks, n) one or more lights, o) one or more table tops, p) one or more chair and/or benches, q) one or more doors, r) one or more windows, s) walls, floor and/or ceiling, t) one or more vents, u) one or more power outlets, v) one or more light and/or power switches, w) one or more USB and/or data connection outlets, and/or x) one or more fans.", "As can be appreciated, the interior cavity or room can include other or additional items.", "The size and configuration of the interior cavity or room can be designed to enable wheelchair access and maneuvering inside the interior cavity or room; however, this is not required.", "For example, the interior cavity or room can be designed to enable a standard wheelchair to move 90°, 180° and/or 360° while in the medical kiosk.", "The size and configuration of the interior cavity or room can be designed to provide sufficient room for the patient so that the patient can easily move within the interior cavity or room and/or the patient does not feel cramped or claustrophobic when in the interior cavity or room; however, this is not required.", "In still yet another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be designed to provide a convenient and low-cost structure (e.g., medical kiosk) that can be placed in many different locations, and which enables patients to conveniently access and obtain medical advice and/or care; however, this is not required.", "Medical providers that are located locally and/or throughout the world can be used to communicate with the patient accessing the medical kiosk.", "As such, the medical services can be offered year around and at all times so long as there is a qualified medical provider somewhere in the world that is available and is qualified to provide medical assistance via the medical kiosk.", "Such an arrangement can be more convenient to the medical provider since the medical provider can work from home or from some other convenient location.", "The arrangement is also convenient to the patient since the patient can access medical assistance via the medical kiosk at the time and place of choosing.", "Indeed, in rural areas or smaller communities that do not have a local hospital or local doctor's offices nearby, the installation of a medical kiosk in the local drug store, department store, grocery store, etc., results in more accessible and timely medical care for patients in such communities.", "The costs associated with providing medical care via the medical kiosk may be less than if the patient seeks medical assistance from a hospital, clinic or doctor's office, thus resulting in the patient potentially saving money.", "As can be appreciated, other or additional advantages may exist by the method of the present invention.", "In another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include the use of a mobile device (e.g., smart phone, tablet, Ipad, Ipod, PDA, etc.)", "and/or computer (e.g., desktop computer, laptop computer, ultralight computer, notepads, etc.", "), home PC, smart TVs, and/or entertainment console [e.g., Xbox systems, PS3, PS4, Apple TV, Amazon Fire TV, etc.", "], etc., or any other device that can access a phone, satellite and/or the internet to enable a patient to 1) conveniently locate an available medical kiosk, 2) schedule an appointment (e.g., date and/or time), 3) pre-register symptoms and/or reasons for visit, 4) set and/or cancel an appointment, 5) received reminders and/or updates regarding appointments, 6) obtain information about medical kiosk availability, 7) obtain information about certain medical provider availability, 8) obtain information about the available medical provider (e.g., name, specialty, etc.", "), 9) enable the selection of a certain medical provider and/or medical provider in a certain field of medicine, 10) obtain map information, address information and/or hours of operation information regarding selected medical kiosk, 11) locate closest kiosk and/or kiosk availability for a certain medical provider and/or medical provider in a certain field of medicine, 12) presubmit and/or preclear medical insurance, 13) submit payment information, 14) receive information on payment status, 15) receive information on insurance coverage, 16) receive appointment reminders and/or updates, 17) receive prescription information, 18) submit payment information for medical visit and/or prescription, 19) answer surveys regarding the use of the medical kiosk, 20) receive medication reminders, 21) obtain payment from patient, and/or other types of information as previously mentioned above; however, this is not required.", "The size, shape, configuration and look of the medical kiosk are non-limiting.", "In one non-limiting embodiment, this invention will allow patients to schedule appointments using a patient portal through a computer and/or mobile device; however, this is not required.", "Another non-limiting aspect of the application will allow the patient to select the kiosk location for their appointment.", "While selecting their appointment time and/or location, the patient can also fill out the symptom survey, select the time of their appointment, and/or select a physician if they choose; however, this is not required.", "The application can also allow the patient to receive appointment reminders via mobile device, smart device, text, phone, cell-phone, web-page, Facebook, twitter, and/or email; however, this is not required.", "The application may also allow for patients to cancel and/or change their appointment; however, this is not required.", "In still another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a mobile application for a mobile device (e.g., smart phone, tablet, Ipad, Ipod, PDA, blackberry device, mobile note device, Kindle device, Nook device, etc.)", "and/or computer (e.g., desktop computer, laptop computer, ultralight computer, notepads, etc.", "), home PC, smart TVs, and/or entertainment console [e.g., Xbox systems, PS3, PS4, Apple TV, Amazon Fire TV, etc.", "], etc.", "or any other device that can access a phone, satellite and/or the internet to a portable device that, when launched, gives the user a series of options that can include, but are not limited to, finding a medical kiosk (e.g., medical kiosk, etc.", "), set medication reminders, visit the home page of the medical kiosk operator, etc.", "; however, this is not required.", "As can be appreciated other and/or additional information can be included on the welcome screen of the mobile application and/or computer-based application.", "The mobile application and/or computer based application can be designed to enable a user to 1) search or and/or locate medical kiosks in one or more communities, towns, cities, states, countries, etc., 2) determine the distance a patient is from a medical kiosk, 3) obtain the directions to a medical kiosk, 4) view the waiting status and/or availability of a particular medical kiosk, 5) obtain a map to the selected kiosk, 6) obtain information about the hours available for the medical kiosk, 7) obtain information about the actual location picture of the medical kiosk, 8) make an appointment with the medical kiosk, 9) obtain information on the hospitals and/or medical providers associated with the medical kiosk, 10) obtain information on which insurance carriers provide coverage for use of the medical kiosk, 11) obtain information on whether a particular medical provider is part of the medical kiosk network of medical providers, 12) obtain public comments about the medical kiosk, 13) contact a helpdesk that provides information about the medical kiosk, 14) schedule an appointment (e.g., date and/or time), 15) pre-register symptoms and/or reasons for visit, 16) enter information required to create an appointment (e.g., personal information, date and time of appointment, particular medical kiosk, particular medical provider, insurance information, payments, ID verification, insurance card, etc.", "), 17) set and/or cancel an appointment, 18) receive reminders and/or updates regarding appointments, 19) obtain information about the available medical provider (e.g., name, specialty, etc.", "), 20) enable the selection of a certain medical provider and/or medical provider in a certain field of medicine, 21) locate closest kiosk and/or kiosk availability for a certain medical provider and/or medical provider in a certain field of medicine, 22) presubmit and/or preclear medical insurance, 23) submit payment information, 24) receive information on payment status, 25) receive information on insurance coverage, 26) receive appointment reminders and/or updates, 27) receive medication reminders, 28) receive visit summaries, 29) obtain/review physician/provider ratings from other users or sources, 30) rate/review physician/provider, and/or any other information as mentioned above; however, this is not required.", "In one particular non-limiting arrangement, the mobile application and/or computer-based application enables a user to schedule an appointment at a medical kiosk.", "The creation of the appointment can be designed to enable the user to a) select the day and/or the time of the appointment, b) select a particular medical provider or type of medical provider (e.g., pulmonary doctor, gynecologist, etc.", "), c) provide a reason for visit and/or provide the user's symptoms, and/or d) set appointment and medication reminders; however, this is not required.", "As can be appreciated, other and/or additional information can be inputted by the user when making an appointment (e.g., sex, age, weight, height, medical history, use of current medications, symptom, allergies, etc.).", "The mobile application and/or computer-based application can be designed to create an appointment confirmation screen along with text and/or email reminder options; however, this is not required.", "The confirmation screen, when provided, can provide information about the medical provider; however, this is not required.", "The confirmation screen, when provided, can be designed to enable the patient to change/cancel the appointment; however, this is not required.", "Several non-limiting advantages of the present invention include allowing a patient to decide which kiosk location is most convenient for the patient.", "The mobile application and/or computer-based application may include an override for “first available” in regards to physician selection; however, this is not required.", "The patient also may be able to check availability of a preferred medical provider and/or the kiosk location; however, this is not required.", "In yet another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a Provider Application wherein the medical provider can contact another medical provider during a patient visit if a special need or question arises during the patient visit wherein the medical provider believes and/or the patient requests a second opinion and/or an opinion from a specialist; however, this is not required.", "The Provider Application can be designed to enable two or more medical providers to be simultaneously viewed and/or heard by the patient in the medical kiosk; however, this is not required.", "The Provider Application can be designed to allow only one medical provider at a time to be viewed and/or heard by the patient in the medical kiosk; however, this is not required.", "The Provider Application can be designed to allow an interpreter to appear to the medical provider and/or patient (e.g., language translator, sign language translator, etc.", "); however, this is not required.", "The Provider Application can be designed to allow a medical provider to contact another party (e.g., patient, guardian, relative, etc.)", "to obtain information, authorization, etc.", "about/for a patient using the medical kiosk; however, this is not required.", "In still yet another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include an Administrator Application allowing a medical administrator to remotely access one or more components of the medical kiosk; however, this is not required.", "The Administrator Application can optionally include one or more functions selected from the group consisting of 1) allowing remote access to one or more medical devices in the medical kiosk, 2) allowing remote access to one or more computers in the medical kiosk, 3) allowing remote access to one or more routers in the medical kiosk, 4) allowing remote access to one or more displays on the medical kiosk, 5) allowing remote access to one or more power supplies in the medical kiosk, 6) allowing remote access to one or more servers in the medical kiosk, 7) allowing remote access to one or more hard drives in the medical kiosk, 8) allowing diagnostics to be executed from a remote location on one or more electronic components in the medical kiosk (e.g., computer, router, server, battery backup, hard drive, medical devices, electronic locks, fans, displays, speakers, camera, headphone jack, electronic scale, Bluetooth devices, lights, pumps, scanners, touch pad, ID verification devices, printer, etc.", "), 9) allowing the rebooting and/or reinitializing from a remote location of one or more electronic components in the medical kiosk, 10) allowing for review of the current and/or past status from a remote location of one or more electronic components in the medical kiosk, 11) allowing hardware and/or software updates to be remotely sent and/or loaded onto one or more electronic components in the medical kiosk, and/or 12) allowing software to be loaded onto and/or removed from one or more electronic components in the medical kiosk.", "In another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a pharmaceutical dispensing system that dispenses medications to the patient; however, this is not required.", "The pharmaceutical dispensing system can be located on the medical kiosk or be a unit separate from the medical device.", "The pharmaceutical dispensing system can be designed to allow the patient to obtain the medication with or without the assistance of the medical attendant.", "The pharmaceutical dispensing system can be designed to only dispense medication that was authorized by the medical provider.", "In one non-limiting arrangement, the medical provider can use the Provider Application to send instructions to the pharmaceutical dispensing system to dispense certain types and/or amounts of medication to the patient; however, this is not required.", "Such information can be stored by the medical provider in the patient's record; however, this is not required.", "The medical provider can send notification to the medical attendant that medication is being dispensed to the patient; however, this is not required.", "The sent information can include type and/or quantity of medication; however, this is not required.", "Non-limiting medication and/or other materials that can be dispensed by the pharmaceutical dispensing system include antibiotics, aspirin, hydrocodone, simvastatin, Lisinopril, levothyroxine sodium, amlodipine besylate, omeprazole, Azithromycin, Amoxicillin, metformin, Hydrochlorothiazide, Lipitor, Nexium, Plavix, Advair Diskus, Abilify, Seroquel, Singulair, Crestor, Actos, Epogen, Band-Aid, tissue, alcohol wipe, bandage, cold pack, heating pad, etc.", "The payment for medication and/or materials from the pharmaceutical dispensing system can be by mobile device, payment at the medical kiosk, payment at attendant's station, and/or payment at the pharmaceutical dispensing system and/or by some other method and/or at some other location.", "In still another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a data port and/or wireless receiver that can be used by a patient to download and/or upload information to a medical device on a patient (e.g., heart monitor, heart pacemaker, implantable cardioverter defibrillators, pulse monitor, activity monitor, temperature monitor, etc.", "); however, this is not required.", "Such information can be designed to be viewed by the medical provider, and/or data can be sent to the medical device by the medical provider; however, this is not required.", "In yet another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be designed to be transported to various locations to be used in an emergency medical station; however, this is not required.", "For example, after a natural disaster (e.g., flood, hurricane, tidal wave, earthquake, fire, tornado, etc.", "), the medical kiosk of the present invention can be transported to the area of the incident and then be used as an emergency medical station.", "As can be appreciated, the medical kiosk can be continuous transported to various locations (e.g., remote rural locations, camp sites, etc.)", "to enable individuals in such locations to obtain medical assistance.", "In still yet another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be designed to allow patients to rate the medical provider and/or to view the ratings of medical providers that have offered services to patients in the medical kiosk; however, this is not required.", "Such ratings can be used by patients to select a certain medical provider for a visit, if such option is available.", "In another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be designed to allow patients to rate the experience received in the medical kiosk and/or to view the ratings of other patients that have used the medical kiosk; however, this is not required.", "In still another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be designed to automatically order supplies for the medical kiosk based on the usage of the medical devices in the medical kiosk; however, this is not required.", "For example, the number of patients using the medical kiosk can be monitored.", "If a thermometer was used for every visit, a software program can be used to automatically order the disposable component of the thermometer after a certain number of patients have visited the medical kiosk; however, this is not required.", "In another and/or additional example, software can be used to monitor the number of times a medical door for a medical device has been opened.", "Based on such number of door openings, a software program can be used to automatically order the disposable component of the medical device in a certain medical compartment after a certain number of door openings has been detected; however, this is not required.", "In still yet another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be designed to generate a fresh scent in the medical kiosk and/or select the background music/sound in the medical kiosk and/or select the lighting level in the medical kiosk and/or select the lighting color in the medical kiosk; however, this is not required.", "The type of scent and/or method of scent delivery are non-limiting.", "The type of lighting and/or light colors available are non-limiting.", "The type of music and/or sound available are non-limiting.", "In another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be designed to collect information about patients, patient retention, and/or patient referrals for use in the marketing of the medical kiosk and/or to improve/alter/enhance the services provided by the medical kiosk; however, this is not required.", "In still another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be designed to print and/or send coupons, advertisements, marketing literature, and/or medical literature to a patient that has used the medical kiosk and/or has registered with the medical kiosk; however, this is not required.", "Such coupons, advertisements, marketing literature, and/or medical literature can be general in nature and/or targeted to the particular patient and/or type of diagnoses received by the patient.", "For example, if a prescription has been written by the medical provider, one or more pharmacies may have a coupon sent to the patient to provide the patient with a discount, etc.", "if the patient fills the prescription at the pharmacy; however, this is not required.", "In yet another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can be designed to facilitate in scheduling a patient for a tele-medicine visit into a remotely located healthcare kiosk; however, this is not required.", "Such process can become quite complicated.", "There can be multiple kiosks, multiple healthcare providers, various regulatory requirements which may limit services in various locations, and/or patient-specific information or requests which may limit available providers.", "In one non-limiting embodiment of the invention, there is provided a system, method and apparatus that can streamline, speed up, and/or reduce wasted time for scheduling tele-medicine patient-provider visits in multitude of remotely located (or home/mobile based) medical kiosks by automating aspects that assist medical providers in managing waiting queues of patients.", "The system, method and apparatus of the present invention can also and/or alternatively assist patients with information about expected wait times.", "The system, method and apparatus of the present invention can also and/or alternatively use wait queuing and/or reservation scheduling for a medical kiosk.", "The system, method and apparatus of the present invention can also and/or alternatively sort patients by insurance provider and/or type of insurance.", "This information can be used to identify one or more medical providers that accept the insurance of the user.", "The information can also or alternatively be used to inform the patient that the user's insurance is not acceptable.", "The information can also or alternatively be used to inform the patient of the amount of payment of the visit based on various factors (e.g., type of insurance, insurance copay amounts, whether insurance is acceptable, type of medical provider requested, a request for a particular medical provider, time of appointment, day of appointment, type of medical condition, etc.).", "In accordance with one non-limiting aspect of the present invention, when a patient checks in to a medical kiosk, the patient is automatically placed into a wait queue.", "Once in the wait queue, one or more medical providers can see the patient in a queuing application based upon configurable patient filtering parameters.", "A medical provider can then optionally start a telehealth visit directly from the queuing application with a “ready” patient.", "If wait times exceed a configurable limit, an alarm can be designed to optionally be initiated to alert medical providers of available patients.", "Patients and providers may optionally use a time slot reservation system in tandem with the wait queue using an auto insert algorithm which inserts a patient into the queue at an appropriate time to meet the reserved time slot.", "This system has several non-limiting advantages.", "For example, patients who check in to a remotely located healthcare kiosk are automatically placed into a wait queue.", "Also, medical providers can optionally see patients who are checked into each healthcare kiosk based on the provider's access credentials.", "Furthermore, patients can optionally be filtered from provider view based upon their location, insurance, medical condition, age, and/or service desired.", "Also, medical providers can optionally have a profile of patient types they are eligible to see which assists in the filtering of patients in the wait queue.", "Furthermore, multiple medical providers can optionally see patient status as checked in, and/or in a ready state along with a patient wait timer.", "Also, patients are optionally sorted by wait time in ready state to make it easy for the provider to find the next available patient with the longest wait time.", "Still further, medical providers can optionally view patient medical history prior to a visit starting if the patient has elected to share their patient medical history with the unknown provider.", "Also, a configurable alarm when a patient is ready to be seen can optionally sound, text, and/or email a medical provider regarding the patient status.", "Also, a configurable alarm for a system administrator can optionally sound if the service level has passed a configurable limit.", "Furthermore, patients can optionally receive an estimated wait time based on an algorithm of past average wait time data in relation to the number of patients ahead in the queue for the given healthcare kiosk.", "Also, patients can optionally reserve a queue “slot” for a set time in the future at a given medical kiosk online, on a mobile device, and/or at the healthcare kiosk.", "Furthermore, when the wait queue at the medical kiosk reaches the time where the patient with a queue slot should be inserted into the queue (according to an algorithm which can estimate the appropriate insertion time), the patient can optionally be automatically inserted into the queue in order to be ready at the appointed reservation slot time.", "Also, the wait queue for a given medical kiosk, or network of kiosks can optionally be modified by an administrator to accommodate no-shows, or late patients/medical providers.", "Furthermore, medical providers can optionally schedule a queue slot for a given patient at a given medical kiosk.", "The reservation system of the present invention can be used to automatically insert the patient at the appointed time to meet the reservation.", "Using the system, method and apparatus of the present invention, the specific scheduling provider can be the only provider who is able to see the given patient in the queue; however, this is not required.", "In prior art health care queuing systems, the patient selects a specific provider in advance of the visit.", "In accordance with the present invention, the medical provider may not be known in advance to the patient, thus the scheduling system allow for a more efficient scheduling of appointments.", "Prior art systems do not deal with the complexity of scheduling a multitude of medical kiosks with specific locations with various network parameters, across a multitude of providers.", "The queuing method of the present invention enables the maximum throughput of patients at a medical kiosk.", "The prior art systems do not instruct on the auto insertion of a patient in a queue based on anticipated visit time.", "A system, method and apparatus of the present invention can streamline, speed up, and/or reduce wasted time for scheduling tele-medicine patient-provider visits in multitude of remotely located (or home/mobile based) medical kiosks by automating aspects that assist medical providers in managing waiting queues of patients.", "In another and/or alternative non-limiting aspect of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include software that can be loaded into existing software (e.g., EPIC, etc.)", "used by a medical provider, hospital, insurance company, medical group, pharmacy, etc.", "so as to create a portal, link, etc.", "to the software used to perform the tele-med services of the present invention.", "The loaded software could be designed to create a widget on the screen of the medical provider, hospital, insurance company, medical group, pharmacy, etc.", "and the clicking of the widget activates the tele-med software on the computer and/or accesses another location to enable the user to perform the tele-med services, access records, view appointments, etc.", "In yet another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a medical kiosk that includes a medical device panel and associated software to aggregate a plurality of medical devices into a single medical device panel and software system; however, this is not required.", "In the past, getting multiple manufacturers' APIs for controllable medical devices approved to work within an MDDS has proved challenging.", "Medical devices require FDA clearance to be used.", "Integrating multiple devices from various manufacturers can create significant challenges for a system integrator or solution provider that is trying to provide a good user experience and remain FDA compliant.", "In most cases, the manufacturer's API does not conform to the integrators needs.", "In accordance with one non-limiting embodiment of the invention, there is provided a system, method and apparatus that can create a standalone FDA- or other type of agency-approvable medical device control panel with a configurable user interface to adapt and harmonize with related software solutions, to interface directly with multiple third-party manufacturer's device integration APIs, and/or to reside as a completely separate module within a larger telehealth software solution.", "In one non-limiting aspect of the present invention, the medical device control panel software is a separate and standalone solution that can be seamlessly incorporated into a larger software solution.", "A system integrator or solution provider can use the control panel to aggregate multiple medical device APIs into a single medical device control software (with modular aspects for various devices) with configurable user interface, to keep all aspects of device control separate from any other software, limiting the FDA or other agency's approval process to this single piece of software.", "Another and/or alternative non-limiting aspect of the present invention is to create a development kit for device manufacturers to create medical device APIs within the architecture of this solution so that configurable medical device controls can easily be shared with various system integrators and the FDA or other agency's approval remains with the original device manufacturer.", "In another non-limiting aspect of the present invention is the ability of a medical provider to optionally remotely control a device through the medical device control panel using an FDA cleared method.", "In addition and/or alternatively, it is possible for the patient to also or alternatively optionally controls the medical device through the medical device control panel.", "Still another and/or alternative non-limiting aspect of the present invention is to optionally send the device data from the control panel directly to an EMR and/or PHR.", "Currently, medical devices that are integrated within a software, wherein the software user interface for device controls has been modified from those originally provided by the device manufacturer, require that the entire software is regulated by the FDA or other government agency.", "The present invention separates the medical device(s) from the overall software solution and allows for a configurable user interface across multiple medical devices, thus eliminating the need to change code in the main non-device software applications, and streamlining FDA or other agency regulatory concerns.", "A development toolkit for device manufacturers can optionally be provided that can be used to create medical device control “widgets” that are reusable and configurable for various system integrators so that the original device manufacturer retains FDA approval or ownership of the device.", "The segmentation of devices requiring various levels of FDA or other agency regulation can coexist in the same control panel.", "A software solution provider can be able to have configuration control of the user interface of a medical device manufacturer's software.", "The medical device control panel solution can be designed to reside in the provider application and the patient application which can be managed locally or in the cloud, separate from the main telehealth application.", "The present invention makes it much easier to gain FDA or other agency clearance for FDA or other agency medical devices where the system integrator or solution provider is not the manufacturer of the device.", "The FDA or other agency controlled aspects of the software can be kept within a single or modular separate software sharing a common medical device control architecture.", "The user interface can be controllable by the medical device control panel software component within the total solution without impacting the FDA or other agency clearance of the devices.", "If the device manufacturer uses the development kit, the medical device API and user interface can be easily reused by multiple solution providers with this invention.", "FDA or other agency clearance and registration can optionally become streamlined for medical device integration of companies using this solution.", "The user interface and usability of devices can be improved by use of the present invention.", "The medical device control panel can optionally be battery and/or USB powered for maximum portability or minimum complexity.", "The present invention is directed to a system, method and apparatus that can create a standalone FDA or other type of agency approvable medical device control panel with a configurable user interface to adapt and harmonize with related software solutions, to interface directly with multiple third-party manufacturer's device integration API's, and to reside as a completely separate module within a larger telehealth software solution.", "In still another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can include a personal medical kiosk that can be used with one or more medical devices.", "In one non-limiting aspect of the invention, there is provided a personal medical kiosk that can be used with a plurality of medical devices that can be contained in a common housing.", "The multipurpose home and/or mobile medical device is designed to be simple to use.", "Most medical devices that are available are single purpose devices that are expensive, and are not necessarily intuitive for a casual or lay user.", "Prior art tele-medicine technologies have attempted to bring a healthcare visit into the home, or mobile device.", "The problem with this type of visit is that the medical provider may not be able to gather enough information about the patient's condition with just a videoconference.", "As a result, many medical device manufacturers have begun developing and selling medical devices that can be connected to a mobile device or to a home PC.", "These devices are commonly developed as “point solutions”, meaning they attempt to solve the problem from the device manufacturer's point of view—using a single device and the device software to connect to an often proprietary physician group—rather than having a mass market approach where the device can become part of another software solution.", "One major reason that the market has developed this way is because of the difficulties in FDA regulation requiring telehealth technology companies to solve complicated regulatory challenges.", "In one non-limiting aspect of the invention, there is provided a multipurpose home and/or mobile medical device that combines a plurality of medical devices into a common housing.", "The multipurpose home and/or mobile medical device is designed to be simple to use.", "The multipurpose home and/or mobile medical device is designed to leverage electronics, communications/connectivity.", "The multipurpose home and/or mobile medical device can also be designed to leverage FDA regulatory clearance of the medical devices.", "The multipurpose home and/or mobile medical device can connect via one or more known interfaces such as, but not limited to, USB, HDMI, Firewire, Bluetooth, IR, wireless technologies, etc.", "In one non-limiting arrangement, the multipurpose home and/or mobile medical device includes some combination or subset of at least two of the following devices: stethoscope, otoscope, dermascope, thermometer, blood pressure, pulse oximeter, ECG, spirometer, and glucometer.", "The multipurpose home and/or mobile medical device can be designed to collect vital information and/or gather images so that a remotely located healthcare provider can be provided with such collected information and make a sound and informed diagnoses of various conditions.", "The multipurpose home and/or mobile medical device can be designed to be simple enough for a patient to use on themselves in a consultation with a provider.", "The data from the multipurpose home and/or mobile medical device can optionally be shared real time, near real time, and/or asynchronously.", "The multipurpose home and/or mobile medical device can optionally be used by the patient to chronicle their vitals and/or capture images of the progress of their condition.", "The multipurpose home and/or mobile medical device can optionally include one or more methods for collecting data in a single housing.", "The patient (user) typically pairs their multipurpose home and/or mobile medical device with a mobile device (e.g., smart phones, tablets, laptop computers, notepads, etc.", "), home PC, and/or entertainment console (e.g., Xbox systems, PS3, PS4, etc.", "), or any other device that can connect to a phone, satellite and/or internet and which allows the multipurpose home and/or mobile medical device to provide data to a medical device software residing on one of these technologies and which controls the display and routing of the data.", "Some aspects of the multipurpose home and/or mobile medical device can optionally be remotely controlled by the healthcare provider.", "The medical device of the present invention combine multiple devices into a single unit for providing the most commonly needed data points for a telehealth medical visit.", "The medical devices can streamline electronics, connectivity and mechanical properties, as well as FDA or other agency registration, by sharing services and capabilities as much as possible.", "The device will minimize the space needed to store all the devices.", "The medical device of the present invention can serve more than one purpose while the prior art is single purpose built.", "The device of the present invention enables one time set-up for connectivity while the prior art requires connectivity for multiple devices.", "The device of the present invention can require a single FDA or other agency registration while the prior art requires FDA or other agency registration for multiple devices.", "The device of the present invention can leverage a medical device control panel software to maximize flexibility, minimize device costs and maximize user experience, while simplifying FDA or other agency regulatory matters.", "This invention can potentially dramatically reduce the cost of having a home telehealth visit and can also or alternatively potentially dramatically improve the quality of the visit.", "In yet another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals can enable a patient to create, own, access and/or enable third parties to access and/or modify the patient's own Patient Health Record (PHR).", "Sharing patient data to healthcare provider networks has created some interesting challenges.", "The traditional model is for a patient to have a HIPAA-based privacy practices relationship with a Covered Entity.", "This allows the Covered Entity (provider) to use patient data with patient permission.", "It also may allow a Covered Entity to share information with a business associate.", "The patient data in a HIPAA relationship is owned by the provider.", "It may be difficult for a patient to gain access to their data and to share it with other providers outside the Covered Entity network.", "A relatively new model for storing patient data has been developed called a Personal Health Record (PHR).", "A PHR puts the patient in charge of their electronic health data, allowing them to retain ownership and share their health data with individuals and providers of their choosing.", "These PHR systems have typically been website repositories where patients input their PHR information.", "In one non-limiting embodiment, there is provided a system, method and apparatus that allows a patient to create, modify, own, access and/or enable third parties to access and/or modify the patient's own PHR record at a medical kiosk and/or at some other location or device (e.g., home PC, mobile device, entertainment center, or any other device that can access the phone, satellite and/or internet, etc.).", "The patient can optionally choose to share the PHR with a medical provider and/or commence a tele-medicine visit all in one convenient location.", "Medical devices with the medical kiosk and/or other location can send data directly to the PHR, storing it securely and optionally allowing immediate retrieval by an authorized provider during a visit.", "The remotely located medical provider can optionally have real time or near real time access to the PHR data, including medical device data from the medical kiosk and/or at some other location.", "The medical provider can optionally be allowed to update the patient's PHR data directly during a visit.", "The patient can have access to the updated PHR data from any phone, satellite, internet and/or intranet enabled device.", "The medical provider may also optionally be allowed by the patient to preserve a copy of the healthcare visit through integration with the medical provider's own EMR system.", "In accordance with one aspect of the present invention, the patient is able to keep their medical history information in a convenient, secure repository.", "The patient can share their data with various individuals, including medical providers.", "The patient inputs their healthcare information on a website, or directly into the medical kiosk or at some other location (e.g., home PC, mobile device, entertainment center, etc.).", "The creation of a PHR account and data at a remotely located, private, medical kiosk and/or some other location (e.g., home PC, mobile device, entertainment center, etc.)", "with medical devices where a tele-medicine visit can occur can be advantageous and convenient to a patient and/or medical provider.", "Another non-limiting advantage of the invention is the ability to create PHR data on a website, and later update and review that data, or simply access and share the PHR created on the website with a provider seen in the medical kiosk and/or some other location (e.g., home PC, mobile device, entertainment center, etc.).", "Another non-limiting advantage of the invention is the ability of a medical device at a remote medical station to send data immediately to the PHR datastore, and to be retrieved immediately by a remotely located provider.", "Another non-limiting advantage of the invention is the ability of a medical provider to immediately receive PHR data from a patient at a remotely located medical kiosk and/or some other location (e.g., home PC, mobile device, entertainment center, etc.)", "to conduct a real time or near real time healthcare consultation.", "Another, non-limiting advantage of the invention is the ability of a medical provider to gather PHR data from the medical kiosk and/or some other location (e.g., home PC, mobile device, entertainment center, etc.)", "consultation directly into the medical provider's own EMR system given a method to gain the express permission of the patient.", "Another non-limiting advantage of the invention is the ability of historical medical data, and/or medical data being created from a medical provider's EMR for a patient being seen in a medical kiosk and/or some other location (e.g., home PC, mobile device, entertainment center, etc.)", "then can be automatically transported to that patient's PHR during or after the visit.", "Another non-limiting advantage of the invention is the ability to enable patient access at a later time to healthcare data generated at the medical kiosk and/or some other location (e.g., home PC, mobile device, entertainment center, etc.)", "via a secure website.", "Another non-limiting advantage of the invention is the ability of a different medical provider, if given permission by the patient, to access the patient history created by one or more other medical providers without needing to contact those other medical providers.", "Another non-limiting advantage of the invention is the ability to create a PHR account at a remote medical kiosk location and/or some other location (e.g., home PC, mobile device, entertainment center, etc.)", "and use it immediately to consult with a medical provider.", "Another non-limiting advantage of the invention is the ability to create PHR data on a website and later use it at a remote medical kiosk and/or some other location (e.g., home PC, mobile device, entertainment center, etc.).", "Another non-limiting advantage of the invention is the ability for the patient to maintain ownership of their health information and share their healthcare data created at the medical kiosk and/or some other location (e.g., home PC, mobile device, entertainment center, etc.)", "with any medical provider or individual of their choosing.", "Another non-limiting advantage of the invention is the ability to have better continuity of care and speed of information sharing.", "In yet another and/or alternative embodiment of the invention, the novel method and apparatus for providing medical services, diagnoses, health, and/or wellness advice to individuals there is provided a medical kit that includes one or more medical devices that can be used with a personal medical kiosk.", "In one non-limiting configuration of the medical kit, there is provided a container that has a base that includes a plurality of compartments for holding one or more medical devices.", "The one or more compartments can also contain other materials and/or devices (e.g., band-aid, bandage, gauze, tweezers, scissors, etc.).", "The container can be made of various types of materials (e.g., plastic, metal, etc.)", "The shape, size and configuration of the container are non-limiting.", "The container can be shaped and size to be portable so that it can be conveniently conveyed and/or used in a variety of locations.", "The lid of the container can include a compartment that is designed to removably hold a tablet computer, smart device, smart phone, IPad, or the like.", "As can be appreciated, the lid of the container can incorporate a permanent display.", "If a tablet computer, IPad, or the like is used with the container, the tablet computer, IPad, or the like is used as the display for the personal medical kiosk.", "The camera on the tablet computer, IPad, or the like is used to convey images to the remotely located medical provider.", "Software can be loaded into the tablet computer, IPad, or the like to interface with the remotely located medical provider, and/or the container can include hardware and/or software that is used with the tablet computer, IPad, or the like.", "The one or more medical devices can be wirelessly connected or directly to the hardware and/or software in the container, and/or be wirelessly connected or directly to the tablet computer, IPad, or the like.", "The container can include a lock or other security arrangement to inhibit or prevent unauthorized use of the container.", "The container can include one or more connectors (e.g., USB, Bluetooth, Wi-Fi, etc.).", "It is one non-limiting object of the invention to provide tele-medicine services that are convenient to a user.", "It is another and/or alternative one non-limiting object of the invention to provide tele-medicine services that are cost effective to a user.", "It is still another and/or alternative one non-limiting object of the invention to provide tele-medicine services that can be provided to a user via a medical kiosk.", "It is yet another and/or alternative one non-limiting object of the invention to provide tele-medicine services that can be provided to a user via a modular medical kiosk.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that is easy to assemble and disassemble.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes an easy and convenient registration system and payment system.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that provides privacy to a user when obtaining medical services.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that is sized and shaped to accommodate disabled or handicapped users.", "It is still yet another and/or alternative one non-limiting object of the invention is to provide a medical kiosk and method for using a medical kiosk that includes medical instruments that can be used by a user when obtaining medical services.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes video conferencing capabilities between a user and a medical provider.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that provides the option to play back one or more portions of the video conference session to the user after the video conference between the user and medical provider has been completed.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes an attendant station, digital signage, and/or a registration station on the exterior of the medical kiosk.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Screen and/or Patient Screen in the interior of the medical kiosk.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes one or more medical device cabinets on the interior of the medical kiosk.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes the use of a Patient Appointment or Registration Application, Attendant Application, Patient Appointment or Registration Application, Provider Application, Administrator Application, Patient Portal and/or Provider Portal.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Patient Appointment or Registration Application that enables patients to schedule an appointment at a medical kiosk.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes Patient Appointment or Registration Application that enables a patient to enter insurance information and/or to make a payment and/or copay for the medical visit in the kiosk.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes Patient Registration System that enables a patient to check-in for a preexisting appointment.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Patient Registration System that enables a patient to identify the patient's symptoms, medications, allergies, and/or medical conditions.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes registration and/or check-in system that enables a patient to request assistance from a medical attendant.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes an Attendant Application that enables a medical attendant to monitor past, present and/or future appointments for the medical kiosk.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes an Attendant Application that enables a medical attendant to monitor the status of a current visit in the medical kiosk.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes an Attendant Application that enables a medical attendant to cancel and/or reschedule an appointment to a medical kiosk.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes an Attendant Application that informs that medical attendant that the patient requires assistance.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes an Attendant Application that enables the medical attendant to keep track of the clean-up of the medical kiosk.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that enables the medical assistant to activate an automated sanitation and/or cleaning system of the medical kiosk.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes an Attendant Application that enables a medical assistant to validate the insurance and/or ID of a patient.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Patient Appointment or Registration Application that helps the patient capture vitals and/or enter the vitals information during the visit.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Patient Appointment or Registration Application that enables the patient to request assistance from the medical attendant.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Patient Appointment or Registration Application that can assist the patient during the consultation with the medical provider.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Patient Appointment or Registration Application that enables a patient to take a survey regarding the consultation with the medical provider and/or the use of the medical kiosk.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that assists the medical provider in providing medical services to the patient in the medical kiosk.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that provides information to the medical provider regarding past, current and future appointment that have been scheduled with the medical provider.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that enables the medical provider to view personal information that the patient has entered regarding the medical visit.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that enables the medical provider to view vitals that have been collected on the patient.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that enables the medical provider to request that the medical attendant assist the patient in the medical kiosk.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that enables the medical provider to control the use and/or access of one or more medical devices in the medical kiosk.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that enables a medical provider to create a visit summary of the patient in the medical kiosk.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that enables the medical provider to update personal information, medical history information and/or symptom information about the patient.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that enables a medical provider to select and/or enter a diagnosis for a patient.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that enables the medical provider to enter notes about a patient and/or create a treatment plan for a patient.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a Provider Application that enable a medical provider to view information about past visits by a patient.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a mobile application and/or an on-line application that enables a patient to 1) conveniently locate an available medical kiosk, 2) schedule an appointment (e.g., date and/or time), 3) pre-register symptoms and/or reasons for visit, 4) set and/or cancel an appointment, 5) receive reminders and/or updates regarding appoints, 6) obtain information about medical kiosk availability, 7) obtain information about certain medical provider availability, 8) obtain information about the available medical provider (e.g., name, specialty, etc.", "), 9) enable the selection of a certain medical provider and/or medical provider in a certain field of medicine, 10) obtain map information, address information and/or hours of operation information regarding selected medical kiosk, 11) locate closest kiosk and/or kiosk availability for a certain medical provider and/or medical provider in a certain field of medicine, 12) presubmit and/or preclear medical insurance, 13) submit payment information, 14) receive information on payment status, 15) receive information in insurance coverage, 16) receive appointment reminders and/or updates, and/or 17) receive medication reminders, and the like.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a scale in the floor of the medical kiosk.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medication adherence application that allows a user/patient to 1) speak to a pharmacist, 2) change the patient's medications alerts, 3) learn about certain types of medical conditions, 4) check medication orders status, 5) check medication delivery status, 6) refill a prescriptions, 7) transfer prescriptions to a another location, 8) obtain information about recommended medication dosages, 9) obtain information about recommended times to take medications, 10) obtain information about recommended frequency for taking medications, 11) obtain information about medications, 12) obtain information about generic brands available for medications, 13) request an appointment to speak with a medical provider, 14) enter information regarding compliance information regarding medication usage by patient, and/or 15) receive compliance reports for patients regarding medication usage.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medication adherence application that 1) sends reminders for user/patients to take their medications, 2) monitors a user's/patient's adherence to taking their medications and/or distributes progress reports to the patient, and/or 3) automatically enrolls a patient in an electronic prescriptions network which can optionally send a patient's prescriptions to their choice of pharmacy.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes one or more headphone jacks in the medical kiosk.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medical kiosk having HD components and an industrial strength design.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medical kiosk having a modular configuration and/or a configuration that enables the medical kiosk to be brought in to or removed from locations having a standard sized doorway.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medical kiosk having a check-in registration system positioned on the exterior of the medical kiosk.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medical kiosk having one or more medical device cabinets located in the interior of the medical kiosk.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medical kiosk having digital signage on the interior and/or exterior of the medical kiosk.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medical kiosk having a built-in sanitation system.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that allows patients to 1) choose between name brand and generic drugs, 2) choose the supply quantity for the prescription (i.e., 30-day supply, 60-day supply, 90-day supply, etc.", "), 3) choose between picking the prescription up at the pharmacy of their choice or mail delivery of the prescription, 4) enter medical insurance for partial or full payment of the prescription, 5) enter a credit or debit card information to pay for the prescription, 6) enter information for mail delivery of the prescription, 7) enter information to provide automatic reminders to patient regarding refilled and/or follow-up medical visits, 8) enter information to enable patient to be notified when prescription has been mailed and/or is ready to be picked-up at the pharmacy; however, this is not required, 9) obtain a printout and/or electronic version of the prescription written by the medical provider, and/or 10) receive information about the issued prescription (e.g., prescribed use, side effects, etc.)", "in printout and/or electronic form.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medical kiosk having a movable front interior wall panel to enable access to components that are positioned behind the front interior wall of the medical kiosk.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a scheduling system for scheduling a patient for a tele-medicine visit into a remotely located healthcare kiosk.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a scheduling system that can streamline, speed up, and/or reduce wasted time for scheduling tele-medicine patient-provider visits in multitude of remotely located (or home/mobile based) medical kiosks by automating aspects that assist medical providers in managing waiting queues of patients.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a scheduling system that can assist patients with information about expected wait times.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a scheduling system that can use wait queuing and/or reservation scheduling for a medical kiosk.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medical device panel and associated software to aggregate a plurality of medical devices into a single medical device panel and software system.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that uses a standalone FDA- or other type of agency-approvable medical device control panel with a configurable user interface to adapt and harmonize with related software solutions, to interface directly with multiple third-party manufacturer's device integration APIs, and/or to reside as a completely separate module within a larger telehealth software solution.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes medical device control panel software that is a separate and standalone solution that can be seamlessly incorporated into a larger software solution.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a medical device control panel software to aggregate multiple medical device APIs into a single medical device control software (with modular aspects for various devices) with configurable user interface, to keep all aspects of device control separate from any other software, limiting the FDA or other agency's approval process to this single piece of software.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a development kit for device manufacturers to create medical device APIs within the architecture of this solution so that configurable medical device controls can easily be shared with various system integrators and the FDA or other agency's approval remains with the original device manufacturer.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes the ability of a medical provider to optionally remotely control a device through the medical device control panel using an FDA cleared method.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that allows the device data from the control panel to be sent directly to an EMR and/or PHR.", "It is still another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a personal medical kiosk that can be used with a plurality of medical devices that can be contained in a common housing.", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that includes a multipurpose home and/or mobile medical device that includes some combination or subset of at least two of the following devices: stethoscope, otoscope, dermascope, thermometer, blood pressure, pulse oximeter, ECG, spirometer, and glucometer.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that enables a patient to create, modify, own, access and/or enable third parties to access and/or modify the patient's own PHR record at a medical kiosk and/or at some other location or device (e.g., home PC, mobile device, entertainment center, or any other device that can access the phone, satellite and/or internet, etc.).", "It is yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a medical kiosk that enables a medical provider to be allowed to update the patient's PHR data directly during a visit.", "It is still yet another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for a personal medical kiosk that includes the use of a medical kit that includes one or more medical devices that can be used with a personal medical kiosk.", "It is another and/or alternative one non-limiting object of the invention to provide a medical kiosk and method for using a personal medical kiosk that includes the use of a medical kit that includes a plurality of compartments for holding one or more medical devices using a personal medical kiosk that includes the use of a medical kit and optionally includes one or more compartments that can contain other materials and/or devices (e.g., band-aid, bandage, gauze, tweezers, scissors, etc.).", "These and other objects and advantages will become apparent to those skilled in the art upon reading and following the description taken together with the accompanying drawings.", "BRIEF DESCRIPTION OF THE DRAWINGS Reference may now be made to the drawings which illustrate various preferred embodiments that the invention may take in physical form and in certain parts and arrangement of parts wherein: FIG.", "1 is an exploded view of a medical kiosk in accordance with the present invention; FIG.", "2 is a front elevation view of the medical kiosk of FIG.", "1; FIG.", "3 is a top view of the medical kiosk of FIG.", "1; FIG.", "4 is a bottom view of the medical kiosk of FIG.", "1; FIG.", "5 is a front side view of the medical kiosk of FIG.", "1; FIG.", "6 is a back side view of the medical kiosk of FIG.", "1; FIG.", "7 is a back view of the medical kiosk of FIG.", "1; FIG.", "8 is a top interior view of the medical kiosk of FIG.", "1; FIG.", "9 is a top interior view of the medical kiosk of FIG.", "1 that illustrates the front interior panel in the open position; FIG.", "10 is a cross-section view along line 10-10 of FIG.", "8; FIG.", "11 is an enlarged view of the medical cabinets of FIG.", "10; FIG.", "12 is a cross-section view along line 10-10 of FIG.", "8 viewed from the opposite direction; FIG.", "13 is a front view of another embodiment of the medical kiosk; FIG.", "14 is a side view of a non-limiting embodiment of a multipurpose home and/or mobile medical device that includes a plurality of medical devices; FIG.", "15-18 are various non-limiting examples of displays for a medical device control panel; and, FIG.", "19 is a front elevation view of a non-limiting personal medical kiosk that is integrated with a medical device kit.", "DETAILED DESCRIPTION OF ONE NON-LIMITING EMBODIMENTS Referring now to the drawings wherein the showings are for the purpose of illustrating one non-limiting embodiments of the invention only and not for the purpose of limiting same, FIGS.", "1-12 illustrate one non-limiting embodiment of the medical kiosk in accordance with the present invention.", "The medical kiosk 100 is designed to be used by a user to obtain medical services.", "Such medical services are generally tele-medicine services wherein one or more medical providers located at a remote location provide medical services to one or more users that are using the medical kiosk.", "As can be appreciated, non-tele-medicine services can also be provided to a user that is using the medical kiosk.", "The shape, size and configuration of the medical kiosk are non-limiting.", "The materials and colors of the medical kiosk are also non-limiting.", "Generally, the materials used to form the medical kiosk include materials that resist or prevent microbial growth; however, this is not required.", "The medical kiosk illustrated in FIGS.", "1-12 is designed to accommodate about 1-4 adults; however, it can be appreciated that the medical kiosk can be designed to accommodate additional users.", "The medical kiosk is generally designed to be modular so that it can be easily assembled and disassembled; however, this is not required.", "FIG.", "1 illustrates one non-limiting set of modular components of the medical kiosk.", "The medical kiosk generally includes a floor panel 110; however, this is not required.", "The floor panel, when used, can be a one or two piece unit; however, the floor panel can be formed of more than two pieces.", "As illustrated in FIG.", "1, the floor panel is formed of two pieces 112, 114 that can be positioned and/or connected together in a variety of ways.", "A rail system 116 can be positioned about the floor panel to facilitate in connecting other components of the medical kiosk to the floor panel; however, this is not required.", "The rail system, when used, can be connected to the floor panel and/or other components of the medical kiosk in a variety of ways.", "The floor panel is generally formed of a durable material (e.g., plastic, metal, wood, composite material, man-made materials, etc.).", "The floor panel can be formed of a slightly compressible material to facilitate in the comfort of walking on the floor panel; however, this is not required.", "The floor panel is illustrated as having an oval shape; however, other shapes can be used (e.g., circular, square, rectangular, polygonal, etc.).", "The maximum length of the floor panel is generally 3-15 feet, typically 4-12 feet, more typically about 6-10 feet, and even more typically about 8-9 feet; however, other lengths can be used.", "The maximum width of the floor panel is generally 3-10 feet, typically 4-8 feet, and more typically about 4-6 feet; however; other widths can be used.", "The top surface area of the floor panel is generally 10-150 sq.", "ft., typically 15-80 sq.", "ft., and more typically about 50-60 sq.", "ft.; however, other surface areas of the floor panel can be used.", "The floor panel can be sized to enable a user in a wheelchair to enter the medical kiosk and turn and/or fully maneuver in the medical kiosk while sitting in the wheelchair; however, this is not required.", "The thickness of the floor panel is generally about 0.1-5 inches, and typically about 0.25-3 inches; however, other thicknesses of the floor panel can be used.", "A weight scale 118 can optionally be partially or fully embedded in the floor panel.", "As can be appreciated, a weight scale can be placed on the top surface of the floor panel and/or positioned on other regions of the medical kiosk (e.g., chair, bench, etc.).", "The weight scale, when used, provides information about the weight of a user.", "The information from the scale can be electronically (e.g., wired, wirelessly) transferred to a medical provider and/or displayed to the user and/or medical provider.", "A ramp 120 can be optionally used to facilitate entry and exiting of the medical kiosk; however, this is not required.", "The shape and size of the ramp are non-limiting.", "The ramp can be made of a similar material as the floor panel; however, this is not required.", "The ramp generally includes a sloped surface to facilitate in transitioning from a floor surface to the top surface of the floor panel; however, this is not required.", "A ramp connector 122 can be used to connect the ramp to the floor panel; however, this is not required.", "The medical kiosk can optionally include one or more benches 130, stools and/or chairs.", "When bench 130 is included in the medical kiosk, the bench is generally positioned on the back interior wall of the medical kiosk; however, this is not required.", "The bench can be used to allow a parent, guardian, spouse, relative, friend, etc.", "to sit in the medical kiosk while the user is obtaining medical services in the medical kiosk.", "The bench can be designed to enable one or more persons to sit on the bench.", "The bench can optionally include a storage space 132 under the seat of the bench that can be used to store supplies, equipment, etc.", "for the medical kiosk.", "A liftable seat section 134 can be used to access the storage space.", "When the bench includes a storage space, the bench can include a door 136 which may or may include a lock to limit access to the storage space; however, this is not required.", "As can be appreciated, the medical kiosk can include one or more chairs, not shown, to enable one or more users to sit in the medical kiosk while receiving medical services in the medical kiosk.", "The bench is generally about 10-25 inches high, and typically about 16-20 inches high; however, other heights can be used.", "The medical kiosk is illustrated as having two front panels 140, 150, two rear panels 160, 170, one side wall 180, and one door system 190.The front panels, rear panels, side wall, and door system are generally formed of a durable material (e.g., plastic, metal, wood, composite material, man-made materials, etc.).", "The front panels, rear panels, side wall can have upper trim 142, 152, 162, 172, 182; however, this is not required.", "As can be appreciated, the medical kiosk can be designed to only include a single front panel and/or a single rear panel.", "As can also be appreciated, the medical kiosk can be designed to include more than two front panels and/or more than two rear panels.", "As can be appreciated, the medical kiosk can be designed to include more than one side wall and/or more than one door system.", "As can also be appreciated, a side wall can be substituted for another door system; however, this is not required.", "The general shape and size of the front and rear panels are the same; however, this is not required.", "As illustrated in FIG.", "1, the shape of the front and rear panels is arcuate.", "The radius of curvature is about 10-100 inches, typically 15-50 inches, and more typically about 20-35 inches; however, other radius of curvatures can be used.", "As illustrated in FIGS.", "1 and 3, the front and rear panels have an angle of curvature of about 90 or a quarter of a circle; however, it can be appreciated that one or both rear and/or front panels can have different angles of curvature.", "The general shape and size of the side wall and the door system are generally the same; however, this is not required.", "As illustrated in FIGS.", "1 and 3, the side wall and door system lie in a generally flat plane; however, this is not required.", "As illustrated in FIG.", "3, the assembly of the front and rear panels and the side wall and door system forms a generally oval shape for the medical kiosk.", "The two front panels and two rear panels are illustrated as having the same or similar footprint; however, this is not required.", "Likewise, the side wall and the door system have the same or similar footprint; however, this is not required.", "The similarity in the shape and footprint of the wall components of the medical kiosk enables the medical kiosk to be assembled in a manner that is convenient for the facility that will include the medical kiosk.", "For example, if the door system needs to be positioned on the left side of the medical kiosk, instead of the right side, the similarly shaped side wall and door system enables the medical kiosk to be assembled in such a manner.", "Also, if the registration station of the medical system needs to be placed on the left side or right side or on the rear end of the medical kiosk instead of the front end, the similarly shaped front and rear panels can be easily exchanged to create such configuration for the medical kiosk.", "The modular medical kiosk not only accommodates multiple configurations of the medical kiosk, it also facilitates in enabling the medical kiosk to be moved into an existing facility and then assembling the medical kiosk in such facility without having to modifying the entry ways into or out of the facility.", "The thickness and height of the front panels, rear panels, side wall and door system are non-limiting.", "Generally, the maximum height of the front panels, rear panels, side wall and door system is about 5-12 ft., typically about 6-9 ft., and more typically about 7-8 ft.; however, other heights can be used.", "The thickness of the front panels, rear panels, side wall and door system is generally about 0.5-10 inches, typically about 1-5 inches, and more typically about 1-2 inches; however, other thicknesses can be used.", "The front panels, rear panels, side wall and door system can optionally include insulation, sound dampening material, etc.", "; however, this is not required.", "The front panels, rear panels, side wall and door system can be designed to be connected together in a variety of ways (e.g., bolted/screwed together, latched together, snap fitted together, press fitted together, etc.).", "Generally, the arrangement is used to connect together the front panels, rear panels, side wall and door system is selected to enable easy connecting and disconnecting of the front panels, rear panels, side wall and door system from one another.", "One or more of the front panels, rear panels, side wall and door system can include openings, windows, transparent/semi-transparent regions that allow for ventilation, illumination, and/or viewing; however, this is not required.", "Generally, front panels, rear panels, side wall and door system are mostly or fully formed of opaque or non-transparent materials so as to ensure the privacy of the user in the medical kiosk; however, this is not required.", "The configuration of the door system 190 is non-limiting.", "As illustrated in FIGS.", "1 and 2, the door system includes a frame 192, 193 and two doors 194, 196; however, it can be appreciated that the door system only includes a single door.", "One or more both doors can include a handle or grasp cavity 198 on one or both sides of the one or both doors.", "The one or more doors can be designed to open and close in a variety of ways (e.g., swing open and closed, slide open and closed on a top/bottom rail system, etc.).", "As can be appreciated, the one or more doors for the medical kiosk can also or alternatively be positioned on one or more of the front or rear panels; however, this is not required.", "The maximum height of the doors is generally about 5-9 ft., and typically about 6-7 ft.; however, other heights can be used.", "The maximum width of the entry provided by the one or more doors when fully open is generally about 15-60 inches, typically about 25-55 inches, and more typically about 30-50 inches; however, other widths can be used.", "The door opening is generally selected to enable a standard wheelchair to pass through the opening; however, this is not required.", "The door system can optionally include an indicator 199 (e.g., light, message, etc.)", "that indicates when the medical kiosk is in use or is available.", "As can be appreciated, the use indicator can be located on other or additional locations on the medical kiosk.", "The door system can optionally include a lock arrangement 197.The configuration of the lock arrangement is non-limiting.", "The lock arrangement, when used, can be designed to enable the user to lock the doors to the kiosk medical to prevent access to the interior of the medical kiosk while the user is in the medical kiosk; however, this is not required.", "The lock arrangement can also or alternatively be used to lock and prevent access to the interior of the medical kiosk when the medical kiosk is not in use; however, this is not required.", "The medical kiosk can optionally include an exterior attendant station that is connected to and/or positioned near the medical kiosk.", "The exterior attendant station can be used by one or more attendants, medical providers, etc.", "As illustrated in FIGS.", "1-5 and 7-9, a desk 200 can be connected to and/or positioned next to an exterior wall of the medical kiosk.", "The desk can be formed of one or more pieces.", "When the desk is designed to be connected to an exterior wall of the medical kiosk, such connection arrangement is not limited (e.g., screw, bolt, clamp, press fit, snap arrangement, etc.).", "The desk can include a desk top 202, one or more legs 203, one or more shelf regions 204, one or more cabinet doors 206, one or more shelves 208, drawers, etc.", "The one or more doors, when used, can optionally include a lock 207.The desk top 202 can optionally include an opening 201 for cables, etc.", "One or more chairs, not shown, can be used to allow one or more attendants, medical providers, etc.", "to sit at the desk.", "The desk can be used to support a computer, printer, files, supplies, medical devices, refrigerator, medicine, patient blood and/or urine samples, phone, monitor, scanner, credit card reader, etc.", "The one or more one or more attendants, medical providers, etc.", "located at the desk can assist a user in using the medical kiosk, maintain and/or clean the medical kiosk, provide medical services to a user of the medical kiosk, etc.", "The desk is illustrated as positioned at or adjacent to one or both front panels; however, this is not required.", "Generally the attendant, when used, is not a medical provider; however, this is not required.", "The attendant, when used, is generally trained to assist a user to use the medical kiosk; however, this is not required.", "The attendant can 1) provide assistance to a user during the registration process and/or payment process, 2) provide assistance to a user about the medical kiosk and/or how to use the medical kiosk, 3) provide assistance to a user regarding technology in the medical kiosk and/or how to use such technology in the medical kiosk, 4) provide assistance to a user to enter and/or exit the medical kiosk, 5) clean and/or sanitize the medical kiosk, 6) answer and/or assist the user in other ways regarding the medical kiosk and/or services provided by the medical kiosk, 7) assist in the registration, appointment and/or check-in process for a user, etc.", "The medical kiosk can optionally include a ceiling panel 210.The ceiling panel can be formed of one or more pieces.", "The ceiling panel can be formed of a transparent or semi-transparent material to allow light to enter and illuminate the interior of the medical kiosk for partial or fully ambient lighting of the medical kiosk; however, this is not required.", "One or more lights, not shown, can be positioned on the ceiling panel to illuminate the interior of the medical kiosk; however, this is not required.", "The ceiling panel is illustrated as including a plurality of vents 212 to enable air to circulate inside the medical kiosk; however, this is not required.", "One or more fans can be positioned on or adjacent to one or more of the vents; however, this is not required.", "As can be appreciated, the location of the one or more fans, when used, is non-limiting.", "As can also be appreciated, one or more fan systems, when used, can also or alternatively be positioned on other components of the medical kiosk (e.g., front panel, back panel, side wall, door system, floor panel, etc.).", "Generally, the rear vents 212 are designed to allow air into the medical kiosk and front vents are designed to allow air to exit the medical kiosk; however, this is not required.", "One or more fan systems, when used, and/or vents can optionally include a filter system, to partially or fully filter dust, mites, airborne particles, microorganisms, viruses, etc.", "from the air prior to the air entering into the medical kiosk and/or prior to the air exiting the medical kiosk; however, this is not required.", "The filter can include many different arrangements (e.g., HEPA filter, electronic filter, liquid filter, etc.).", "The medical kiosk can optionally include a cleaning system that is designed to clean one or more portions of the interior of the medical kiosk and/or kill/neutralize some or all germs and/or other microorganisms in the medical kiosk.", "One non-limiting cleaning system that can be used is a UV sanitizing system 220.As can also be appreciated, a mist sanitizer can also or alternatively be used to fully or partially clean/sanitize one or more portions of the medical kiosk.", "As illustrated in FIGS.", "1, 8, 9 and 12, the UV sanitizing system 220 can be connected to or positioned adjacent to the ceiling panel and rear panels; however, this is not required.", "The UV sanitizing system generally includes one or more UV lights that are designed to kill some or all of the germs and/or other microorganisms in the medical kiosk.", "Generally the germs and/or other microorganisms in the medical kiosk are treated when the interior of the medical kiosk does not include a user.", "The UV sanitizing system can optionally include one or more standard lights that can be used to provide illumination in the medical kiosk; however, this is not required.", "The UV sanitizing system can optionally include one or more vents that allow air drawn into the medical kiosk by a fan system to flow into the interior of the medical kiosk; however, this is not required.", "The UV sanitizing system can optionally include a cooling fan for the one or more UV lights and/or optional standard lights; however, this is not required.", "The UV sanitizing system can optionally include all or a portion of a mist sanitizing system; however, this is not required.", "The UV sanitizing system can house one or more cameras, speakers, sensors (e.g., temperature sensor, motion sensor, sound sensor, etc.", "), etc.", "for use in the medical kiosk; however, this is not required.", "The UV sanitizing system includes a shroud 222 that includes vent/light openings 224 to house the components of the UV sanitizing system; however, this is not required.", "The shape, size and configuration of the shroud are non-limiting.", "When a mist sanitizing system is additionally or alternatively used, one or more mist nozzles can be located in one or more regions of the medical kiosk so as to direct the sanitizing mist to desired locations in the medical kiosk.", "The sanitizing system, when used, can be activated by an attendant and/or a medical provider while the medical kiosk is not being used by a user.", "The doors to the medical kiosk can be closed and/or locked to prevent a user from entering the medical kiosk during a sanitizing process; however, this is not required.", "The one or more cleaning/sanitizing systems can be used to clean the air in the medical kiosk, clean one or more surfaces of the medical kiosk (e.g., floor, bench, display screen, cabinet surfaces, chair, etc.)", "and/or a portion of all of the surfaces of a medical device.", "When the mist system is used, the mist system can be designed to direct the cleaning mist onto one or more locations in the kiosk.", "When the UV sanitizing system is used, the UV light can be designed to be directed onto one or more regions in the kiosk.", "Referring now to FIGS.", "1-5 and 7-10, front panel 150 includes a registration station 230.The registration station is illustrated as including a touch screen 232, a display screen 234, and an optional frame 236 that such components can be mounted thereto.", "The shape of the frame, when used, is non-limiting.", "The frame, when used, can be designed to be easily removed from the front panel to enable servicing, repair, replacement, etc.", "of one or more components of the registration station; however, this is not required.", "As can be appreciated, the registration station can also or alternatively include other or optional features (e.g., additional display screen, additional touch screen, lights, buttons, switches, camera, speakers, microphone, keyboard, scanner, receiver, transmitter, credit card/debit card or other some other card reader, smart phone or other smart device reader/scanner, finger and/or eye scanner, shelf, printer, storage cavity, service access door, motion sensor, sound sensor, temperature sensor, logos, etc.).", "The touch screen is generally used to allow a user to enter in information about the user (e.g., age, sex, contact information, payment information, medical history, medical issue, etc.).", "The touch screen can be substituted for a keyboard; however, this not required.", "The frame is designed to mount the touch screen at some angle (e.g., 10-80°) relative to the front plane of the front panel 150 as illustrated in FIGS.", "1, 2 and 5; however, this is not required.", "The frame optionally includes one or more side sections 238, 240 that can include one or more other or optional features of the registration station.", "As can be appreciated, one or more other or optional features of the registration station can also or alternatively be located on other regions of the registration station.", "The touch screen can display various types of information (e.g., electronic keyboard, instructions on how to register, questions that are displayed during registration, instructions during registration, information displayed to user during registration, various templates, various menus, various lists of information, etc.).", "As can be appreciated, the medical kiosk can be designed to accept voice commands during the registration process; however, this is not required.", "The display screen can be used to provide various types of information (e.g., registration information, information input by the user, advertising information, information about the medical kiosk, information about wait time for a medical kiosk, information as to the order of users waiting to use the medical kiosk, information about whether a medical kiosk is available or in use, cable TV, satellite TV, local broadcast TV, infomercial, medical programs, DVD materials, Blu-ray materials, video streaming, etc.).", "Generally, a user enters payment information at the registration station (e.g., swipes a credit or debit card, etc.", "); however, it can be appreciated that payment information can also or alternatively be entered inside the medical kiosk, at the optional attendant station, wirelessly or over a network via a smart phone or other device or by a computer connected to a network, etc.", "If an attendant is available, the attendant can assist a user during the registration process; however, this is not required.", "Generally, the medical kiosk includes a single registration station; however, this is not required.", "As can be appreciated, the registration station can alternatively be located inside the medical kiosk, at the attendant station, on other panels or sidewalls of the medical kiosk, or located remotely from the medical kiosk (e.g., central registration center for use with multiple medical kiosks, etc.).", "Referring now to FIGS.", "1 and 8-12, a non-limiting interior of the medical kiosk is illustrated.", "As previously discussed, the interior room or cavity of the medical kiosk can optionally include a scale 112, a bench 130 and/or a UV sanitizing system 220.Referring now to FIGS.", "8-11, a non-limiting interior front region of the medical kiosk is illustrated.", "The interior chamber of the medical kiosk includes a front interior panel 300.The front interior panel 300 can be connected to front panels 140 and/or 150.As illustrated in FIG.", "9, the front interior panel can be pivotally connected to front panel 140 to enable the front interior panel to be moved away from front panel 150; however, this is not required.", "The movement of the front interior panel can be used to allow access to the components (e.g.", "computer, router, server, battery backup, hard drive, medical devices, electronic locks, fans, displays, speakers, camera, headphone jack, electronic scale, Bluetooth devices, lights, pumps, scanners, touch pad, ID verification devices, printer, etc.)", "that are located between front panels 140 and 150 and front interior panel 300; however, this is not required.", "Such access can be used to facilitate in the service, maintenance, upgrading, replacement, etc.", "of such components; however, this is not required.", "The front interior panel can include a lock; however, this is not required.", "The front of the front interior panel can include a desk top 302 that is used to support one or more touch screens 310, touch pads or keyboards positioned on the desk top.", "The shape, thickness and size of the desk top are non-limiting.", "The desk top is illustrated as secured to or formed on the front interior panel 300; however, this is not required.", "The desk top can have one or more support legs, not shown; however, this is not required.", "The one or more touch screens, touch pads, keyboards, etc.", "on the desk top can be secured to the desk top; however, this is not required.", "The desk top is illustrated as sloping downward toward the front edge; however, this is not required.", "The size, shape and thickness of the one or more touch screens, touch pads, keyboards, etc.", "are non-limiting.", "The one or more touch screens, touch pads, keyboards, etc.", "are designed to be used by a user to enter various types of information (e.g., quality survey, patient history, patient medical information, payment information, questions to medical provider, vitals, etc.)", "before, during and/or after receiving medical services.", "As can be appreciated, the one or more touch screens, when used, can additionally or alternatively be used to provide information and/or instructions to the user and/or can provide other uses for the user (e.g., use policy, instructions on how to use the medical kiosk and/or medical devices, providing information on next step of medical visit, request assistance, increase/decrease speaker volume, increase/decrease headjack volume, focus medical devices, adjust volume of medical devices, adjust lighting in kiosk, etc.)", "during use of the medical kiosk; however, this is not required.", "The desk top can optionally include one or more other devices (lights, buttons, switches, camera, speakers, microphone, scanner, receiver, transmitter, credit card/debit card or other some other card reader, smart phone or other smart device reader/scanner, finger and/or eye scanner, shelf, printer, storage cavity, motion sensor, sound sensor, temperature sensor, logos, scanner, etc.", "); however, this is not required.", "A chair, not shown, can be provided to enable the user to sit when using the medical kiosk.", "The chair can be a free standing chair or be connected to the medical kiosk.", "One or more monitors or display screens 320 can be positioned on the front of the interior front panel.", "As can be appreciated, one or more monitors or display screens can be positioned on other or additional locations in the medical kiosk.", "The shape, size and thickness of the one or more monitors are non-limiting.", "The monitor is generally used to view the one or more medical providers when the user is located in the medical kiosk.", "The one or more monitors can also or alternatively display other or additional information (e.g., instructions, questions, general medical information, time, output or results of examination of user, vitals information, results from the medical devices, advertisements, information about the medical kiosk, information being displayed and/or entered by the user on the touchscreen, etc.).", "One or more cameras (e.g., video camera, etc.)", "can be positioned on the interior wall panel and/or be embedded in the one or more monitors or display screens 320.As can be appreciated, one or more cameras can be positioned on other or additional locations in the medical kiosk.", "The one or more cameras enable pictures of the user in the medical kiosk to be transmitted to a remotely located medical provider.", "The remotely located medical provider also typically includes a camera at his/her location so that pictures of the medical provider can be transmitted to the one or more monitors or display screens 320 in the medical kiosk.", "Such an arrangement can allow for real-time or near real-time video conferencing between the user and medical provider while the user is located in the medical kiosk.", "The one or more cameras can have other or additional functions (e.g., determine height of user when standing on scale or other locations in the medical kiosk, view one or more regions of user so as to provide a medical examination of the user in the medical kiosk, monitor occupancy of the medical kiosk, provide security monitoring for the medical kiosk, etc.).", "The one or more monitors or display screens 320 in the medical kiosk can also be used to replay one or more portions of the video conference between the user and medical provider after the secession with the medical provider has ended; however, this is not required.", "Such a feature, when available, enables the user to review or again listen to instruction, advice, etc.", "provided by the medical provider to the user.", "This video playback feature, when available, can be limited to being viewed by the user while the user remains in the medical kiosk, or can also or alternatively be accessed be the user after the user exits the medical kiosk; however, this is not required.", "If the user can optionally access the recorded video conference outside the medical kiosk, the video file can 1) be accessed from some central server, 2) electronically sent to a personal computer, mobile device, tablet, laptop, etc., and/or 3) mailed to the user (e.g., DVD, Blu-ray disk, video tape, USB jump drive, etc.).", "One or more speakers 330 can be positioned on the front interior panel of the medical kiosk.", "As can be appreciated, one or more speakers can be positioned on other or additional locations in the medical kiosk.", "The speakers can be used to enable a user in the medical kiosk to listen to what the medical provider is saying to the user.", "One or more microphones are generally included in the medical kiosk to enable the user to verbally communicate with the medical provider.", "The medical kiosk can optionally include a braille keyboard and/or reader to enable the visually and/or hearing impaired to communicate with a medical provider while in the medical kiosk.", "The speakers can also or alternatively be used to play background music, sound an alarm, etc.", "A headphone jack 340 can be provided on the interior front panel and/or other locations in the medical kiosk to enable headphones to be connected to the medical kiosk; however, this is not required.", "The interior front panel and/or other locations in the medical kiosk can include one or more data ports (e.g., USB, Ethernet, Firewire, etc.)", "to enable medical devices, storage devices, smart phones, computers, tablets, and/or other devices to be connected to the medical kiosk; however, this is not required.", "For example, the data port could be used by a patient, to download and/or upload information to a medical device on a patient (e.g., heart monitor, heart pacemaker, implantable cardioverter defibrillators, etc.).", "The front interior panel 300 can optionally include one or more air vents 350.The one or more air vents, when used, can enable air to enter or exit an interior location positioned between the front wall panels and the front interior panel to thereby provide circulation in the medical kiosk.", "Such interior location can include one or more fans to draw air through the one or more vent and into the interior location; however, this is not required.", "As illustrated in FIGS.", "8 and 8, the interior location can include a computer 360, a router, a server, a battery backup, a hard drive, medical devices, electronic locks, displays, speakers, camera, headphone jack, Bluetooth devices, lights, pumps, devices, printer, etc.", "Such devices can generate heat during operation, thus the air flow can be used to provide cooling for such devices.", "The front interior panel can include one or more equipment chambers 370 can be positioned on or near the front interior wall.", "The equipment chambers are used to store one or more medical devices (e.g., stethoscope, otoscope, thermometer, dermascope, spirometer, pulse oximeter, heating pad, magnifying glass, tongue depressor, tweezers, blood glucometer etc.).", "The one or more equipment chambers can also or alternatively be used to include other types of materials (e.g., tissue, Band-Aid, gauze, cotton ball, disinfecting wipe, cortisone cream, antibiotic cream/ointment, cotton swab, fabric wrap, etc.).", "The one or more equipment chambers generally include a door 372 to limit access to the one or more equipment chambers; however, this is not required.", "The door, when used, can be manually openable/closeable, and/or the doors can be controllably opened/closed remotely by the medical provider and/or attendant.", "Generally, the doors are controllably opened and/or unlocked by the medical provider during the examination of the user in the medical kiosk.", "After the user has left the medical kiosk, the attendant can enter the medical kiosk, and then clean the medical equipment that was handled or used by the prior user and/or dispose of and/or replace items that were used and/or handled by the prior user.", "Thereafter, the attendant can restock, replace, and/or reposition the medical equipment and/or non-medical equipment in the equipment chambers and close the equipment chamber doors prior to the next user entering the medical kiosk.", "One or more types of medical equipment can be designed to transmit information by wire or wirelessly to electronic components in the medical kiosk and/or to the remotely located medical provider.", "As illustrated in FIGS.", "10 and 11, six equipment chambers having doors are included in the medical kiosk, three on each side of the desk top 300.As can be appreciated, a larger or smaller number of equipment chambers can be used.", "As also can be appreciated, some or all of the equipment chambers can be absent doors.", "The doors on the six equipment chambers are designed to be unlocked and/or opened remotely by the medical provider and/or during the taking of vitals by the patient.", "The doors are designed to automatically lock closed when the doors are closed by the attendant after the user has left the medical kiosk; however, this is not required.", "Each of the six equipment chambers is designed to include a different piece of medical equipment, namely a stethoscope 380, an otoscope 390, a thermometer 400, a dermascope 410, a spirometer 420, and a pulse oximeter 430.As can be appreciated, a larger or smaller number of medical equipment can be used in the medical kiosk and/or different types of medical equipment can be included in the medical kiosk.", "Referring now to FIG.", "13, there is illustrated an alternative configuration for the medical kiosk 100 of the present invention.", "In this embodiment, floor 110, doors 190, panels 140, 150, 160 and 170, ceiling 210, ramp 120, bench 130 and UV sanitizer 220 are absent from the medical kiosk.", "The attendant desk 200 may also be absent.", "In this non-limiting arrangement, the medical kiosk 100 can be placed in a private room and/or some other location.", "The medical kiosk includes a registration station 230 that can be the same or similar as the registration station described above.", "The medical kiosk can include front wall panels 140 and 150 or a single wall front wall panel.", "The medical kiosk includes interior front panel 300 which can be the same or similar to interior front panel 300 as described above in FIGS.", "1 and 8-11.The interior front panel can be pivotally connected to the one or more front wall panels; however, this is not required.", "The interior front panel may or may not include a Physician Screen 340.If interior front panel is the same or similar to interior front panel 300 as described above in FIGS.", "1 and 8-11, then the user can have a teleconference with a medical provider.", "However, if interior front panel does include a Physician Screen 340 and one or more other components (e.g., speakers 330, headphone jack 340, etc.", "), then the user may only be able to collect one or more vitals and then proceed to another location to visit a medical provider.", "As can also be appreciated, the medical kiosk can also be absent the desk top, medical device compartments, Patient Screen and the like such that the medical kiosk primarily includes the registration station 230 to enable a user to check-in for a visit with a medical provider.", "As can be appreciated, one or more features of the medical kiosk of the present invention can be used in other ways to provide medical services to a user.", "The medical kiosk and method for using the medical kiosk are a novel and advanced healthcare delivery system wherein patients and physicians can engage in real-time interactive consultations, providing convenient and affordable healthcare services.", "The medical kiosk includes the latest technologies in medical devices, video conferencing, and VOIP telephony so that the medical kiosk can extend traditional healthcare to convenient retail pharmacy locations or other locations in a user's neighborhood, therein enabling a user to see a medical provider and obtain a prescription, if required, in a fast and convenient manner.", "Some advantageous aspect of the medical kiosk and medical method are: Patient Portal (Cloud Based).", "Provider Portal (Cloud Based).", "Integrated Care Station.", "Facilitates Efficient Delivery of Basic Healthcare Delivery.", "Automates All Aspects of a Check Up.", "Easy Check-In.", "Vital Signs Capture.", "Prescription Generation.", "Post Care and Outcomes.", "Convenient Locations Where Consumers Want To Be.", "Video playback of the recorded session between the user and medical provider.", "The medical kiosk and medical method can be used to provide primary and/or urgent care services in four (4) simple steps: Step 1—Patient Begins/Completes Check-in Process Via Web Portal or at the Medical Kiosk.", "The patient can optionally begin the check-in via web portal and then later complete check-in process at the medical kiosk; however, this is not required.", "A medical provider can send a reminder to patient regarding an appointment and/or begin the check-in process for a patient (e.g., follow-up appointment, etc.", "); however, this is not required.", "Step 2—Medical provider receives eligible request and accepts and/or is assigned to patient.", "Step 3—Patient visits the medical kiosk and has a private appointment with a doctor via the Patient Screen.", "Step 4—Visit is completed.", "The medical kiosk and/or medical provider can then provide additional care/services that include: prescription, billing information, education, referrals, follow up and/or EMR/PHR entry.", "The medical provider can cause the medical kiosk to printout a prescription and/or directly send the prescription request to a pharmacy.", "The medical kiosk can print out a bill after the medical services are provided and/or accept payment prior to or after medical services are provided.", "The medical kiosk can be designed to accept and/or process medical insurance information provided by the user.", "The medical kiosk can print out and/or display education materials/information relevant to/requested by the user and/or provided by the medical provider.", "The medical kiosk and/or medical provider and/or attendant can schedule a follow-up visit for the user.", "Email, twitter, Facebook, test, and/or mail reminders can be sent to the user regarding scheduled and/or follow-up visits.", "The medical provider and/or attendant can schedule a visit with another medical provider and/or admit the user to the hospital, contact an ambulance, etc.", "during or after the visit to the medical kiosk.", "A visit summary can be printed out and/or sent to the patient.", "As can be appreciated, the medical kiosk and method for using the medical kiosk can have other or additional features.", "Advantageous portal features of the medical kiosk and associated medical method are: Practice Management Engine.", "Appointments Scheduling Engine.", "Online Eligibility, Claims, and Billing Engine.", "ePrescribing with Alerts and Reminder Engine.", "Medical Records Interface and Access.", "Personal Health Record (PHR).", "Electronic Medical record (EMR).", "Rules-Based Care Plans.", "Rules-Based Education.", "Check In Pathway to Care Engine.", "Secure Video Conferencing Engine.", "Documentation Module.", "Appointment Storage and Analysis.", "Education and Post Care.", "Some non-limiting advantages to patients by use of the medical kiosk and medical method are: Convenient.", "Closer to home.", "Saves time.", "Language and culture friendly.", "Better Access.", "Personal doctor available while traveling.", "Larger selection of doctors.", "Not limited by doctor's visitation schedule.", "More Accurate.", "Review record of appointment.", "Automatic data entry into PHR.", "Less Exposure to Illness.", "Some non-limiting advantages to medical providers by use of the medical kiosk and medical method are: Higher Revenues.", "More appointments/day.", "Less traveling.", "More Accurate.", "Review record of appointment.", "Automatic data entry into EMR/HER.", "Integrated Care.", "Referral and transfer.", "Load Balancing.", "Appointment load can be shared with other doctors regardless of location.", "Some non-limiting advantages to payers by use of the medical kiosk and medical method are: Change in Status.", "Transition from Payer to Provider.", "Market Leverage.", "New Business Model.", "Call Center based Nurse Practitioner.", "Efficiency.", "Market Demand.", "Less Overhead.", "Scalability.", "Less Liability.", "The medical kiosk of the present invention is an Integrated Care Terminal that is a highly equipped doctor's office that is built and designed to deliver urgent and minor medical care in the field utilizing a centralized team of doctors for the evaluation and treatment of patients.", "The medical kiosk can be fitted with the latest FDA approved medical devices used by doctors today.", "Employing the latest technology that is used in physician offices and emergency rooms, the medical kiosk is able to allow patients to obtain appropriate care in locations that are convenient, accessible, and more affordable.", "The medical kiosk is designed to be a comfortable, self-contained, secure, sanitary, soundproof kiosk that is approximately 5 feet wide and 9½ feet long; however, it can have other dimensions.", "The medical kiosk can be made of extruded plastics and related components.", "The interior of the medical kiosk can contain one or more of the following integrated medical devices: Thermometer (e.g., temperature taken via ear, temperature taken via ear, IR thermometer to scan head or other area of body, etc.).", "Scale built into the patient seat or floor for measuring the patient's weight.", "Otoscope—for examining the middle ear, exterior ear, nasal passages, mouth and throat.", "Oximeter which measures the blood oxygen saturation.", "Stethoscope for evaluation of heart, lung and bowel sounds.", "Blood Pressure Cuff to measure blood pressure.", "EKG which provides a snapshot of the heart rhythm and data regarding stress or injury to the heart muscle.", "Spirometer and transducer for measuring lung function.", "Blood glucose measuring device or monitor.", "Retinal scan device (e.g., Itronix retinal scan device, etc.).", "Dermascope.", "A medical attendant (e.g., medical assistant, nurse assistant, nurse, nurse practitioner, physician, etc.)", "who resides outside the medical kiosk can be responsible for answering user questions, assisting with user registration/payment, thoroughly clean the medical kiosk after each use, and restock and/or reset the medical kiosk after each use.", "The cleaning of the medical kiosk can include sanitizing the seat, touch screen, floor, walls, seat, and all instruments as well as ensuring the medical kiosk is free of debris and any patient belongings.", "The medical kiosk can also be designed to be automatically sterilized after one or more users use the medical kiosk by utilizing a chemical mist sterilization technology and/or UV sterilization technology.", "The medical attendant can also ensure that any insurance forms required by the user/patient for reimbursement are provided via a printer or some other means contained in the exterior and/or interior of the medical kiosk.", "The medical kiosk can also contain one or more computers, which are connected to the internet and powers the one or more monitors and/or other type of equipment in the medical kiosk; however, this is not required.", "The exterior monitor on the medical kiosk can be used for patient registration and appointment selection that can be conducted in a touch screen format.", "The method for providing medical services via a medical kiosk regarding protocols for scheduling, diagnosing, delivering and documenting tele-medicine primary care can include: a.", "Medical Provider Application—this application is used by the medical provider to provide clinical services.", "The application contains all that the medical provider requires to diagnose, deliver care and document the clinical episode.", "It runs on the physician's computer and can be integrated with the leading EMR applications.", "b.", "Patient Application—this application is used by the patient to register with a medical kiosk and also captures the patient's medical history and/or vitals.", "It includes all the information required to administer clinical services to the patient.", "This includes financial/billing information and a Healthspot Electronic Medical Record (EMR), which can be accessed by the patient and the medical providers.", "c. Integrated videoconferencing software—this application supports the live patient-clinician interaction required for delivery of the clinical services.", "It uses a secure connection to the servers and the provider via an internet connection.", "To use a medical kiosk, the users/patients may go through one or more of the following steps: a.", "Go Online, register and schedule an appointment at the nearest terminal or walk-in and register at the medical kiosk.", "b.", "Use the scheduling engine to select an appointment time.", "c. Input insurance, preferred pharmacy location and/or billing information, and remit payment.", "d. Complete pre-appointment pathway to care.", "e. Visit a medical kiosk and see a medical provider via the integrated care terminal.", "f. Pick up prescription, if indicated, at the pharmacy of choice.", "g. Optionally use website to manage user's care until user is better.", "The following example is a non-limiting example as to what one user may encounter when using the medical kiosk of the present invention: Jane Doe is not feeling well, suffering from severe nasal congestion and “cold symptoms” for several days.", "She realizes she should seek care, but finds it frustrating to schedule an appointment with her primary care physician and knows that this is not an appropriate reason to visit her local ER.", "However, she recently became aware of a medical kiosk in her neighborhood grocery store, and decides to drive to the store a few minutes from her home to see if she can get a walk-in appointment.", "Upon arrival, Jane is met by the attendant who helps her register at the exterior of the medical kiosk for the next available appointment in a few minutes.", "She completes the basic information about her medical condition in a short guided questionnaire via the monitor on the exterior of the terminal.", "The intake questionnaire captures demographic information that can include some or all of the following information: name, address, gender, race, native language, age, birthdate, fingerprint, simple medical history/medications, current symptoms, allergies, medical condition, medications currently used, preferred pharmacy, insurance information, and a debit/credit card payment and/or some other types of payment for the visit, and/or time of next available visit in kiosk.", "Information is gathered and stored securely to facilitate future visits.", "Jane then has a seat at a small waiting area near the medical kiosk.", "When the appointment prior Jane's ends by another user, Jane witnesses the attendant cleaning the appropriate surface areas of the interior of the medical kiosk, and the changing the protective covers of the instruments that were used.", "Jane then proceeds to check-in to the kiosk by providing a password or some other type of ID.", "This check-in can occur with the registration station on the kiosk and/or with the medical attendant.", "Once checked-in, the medical attendant escorts the patient into the medical kiosk.", "The medical assistant also fits a blood pressure cuff on the patient, connects the blood pressure cuff to the medical kiosk, and then begins the vital capture process for the patient.", "The medical attendant may or may not be present during the complete vitals capture process.", "During the vitals capture process, the weight and temperature of the patient is also collected.", "The Patient Application provides information to the patient on how to proceed with the vitals capture process.", "Once the vital capture process is completed, the patient presses a button or indicates in some other manner that the patient is ready to proceed with the teleconference with the medical provider.", "During the vitals capture process, the medical provider can view Jane's medical history, current medications, symptoms and/or any other information that Jane's entered during the registration process.", "The medical provider can also view the results of the vitals that were captured during the vitals capture process.", "Once the medical provider receives information that the patient is ready for the teleconference, the medical provider selects the option to create such connection.", "The medical provide then appears on the Provider Screen in the medical kiosk and the patient appears on the screen being used by the medical provider.", "The medical provider can then question and examine Jane during the teleconference.", "After the medical provider has spoken to Jane, he suspects a possible sinus infection.", "The medical provider then clicks on a button on the Provider Application which causes a door to a medical device cavity or compartment on the medical kiosk to open for the otoscope.", "The medical provider then instructs Jane to gently insert the device in her nose and takes a picture of her nasal mucosa.", "The picture is displayed on the medical provider's screen and optionally displayed on the Patient and/or Provider screen in the medical kiosk for Jane to see.", "The medical provider proceeds to instruct Jane to use the instrument to look in her ears and throat.", "The medical provider views the pictures and determines that the throat and nasal passages are inflamed which is indicative of an upper respiratory infection.", "Based on her symptoms and the examination, the medical provider tells Jane he believes that she has a sinus infection.", "The medical provider can optionally prescribe a prescription for the appropriate antibiotic which can be e-prescribed by the medical provider and sent electronically to the pharmacy of Jane's choice, which in this case happens to be the pharmacy within the grocery store.", "Prior to or after Jane exits the medical kiosk, Jane may take a survey of the visit.", "Jane may optionally complete an insurance form from the attendant, which she can use to file with her insurance company for reimbursement.", "Jane then walks over to the pharmacy and waits on her prescription, which is available ten minutes later.", "She returns home and begins taking the medication to cure her sinus infection.", "Some of the non-limiting features of the medical kiosk are: Integrated Medical Devices.", "Exterior Check-In Station.", "Patient Waiting Area.", "Integrated Wi-Fi Hot Spot.", "Touch Screen User Interface.", "HIPAA Compliant Design.", "Instant Sterilization.", "Video/Audio Conferencing.", "Flexible Access.", "Handicap.", "Parent and Child.", "Modular design for Pharmacy door deployment.", "Small Footprint.", "Fully Integrated Interior Design.", "Expandable Device Rail.", "Secure PC storage with access.", "Open design feels comfortable.", "Payment and Signature.", "Finger Print Reader.", "Integrated Printer.", "Integrated Medical Devices.", "Thermometer—(e.g., temperature taken via ear, temperature taken via ear, IR thermometer to scan head or other area of body, etc.", "Scale built into the patient seat or floor for measuring the patient's weight.", "Otoscope—for examining the middle ear, exterior ear, nasal passages, mouth and throat.", "Oximeter which measures the blood oxygen saturation.", "Stethoscope for evaluation of heart, lung and bowel sounds.", "Blood Pressure Cuff to measure blood pressure.", "EKG which provides a snapshot of the heart rhythm and data regarding stress or injury to the heart muscle.", "Spirometer and transducer for measuring lung function.", "Blood Glucose measurement device and/or monitor to measure blood glucose levels.", "Retinal scan device to view structures in the eye.", "Dermascope to view the skin and/or throat.", "Blood analyzer to measure different chemicals in the blood (e.g., glucose, serum albumin, creatinine, etc.)", "and/or other characteristics of the blood (e.g., blood cell count, enzyme levels, ion levels, measure ability of blood to clot, etc.).", "Exterior Check-In Station—A monitor and keyboard is generally mounted on the outside of the medical kiosk to allow for new user/patient registration and check in.", "The station can be designed to take payment and/or a fingerprint.", "The station generally is located away from the entrance to the medical kiosk to allow a degree of separation from the patient inside the medical kiosk.", "The attendant can use this station for her work.", "Patient Waiting Area—Can include a small area to put a few chairs outside the medical kiosk to act as a waiting area.", "Integrated Wi-Fi Hot Spot—In order to minimize network connection cost, a Wi-Fi hot spot can partner with an ISP of choice (AT&T, Verizon, Sprint, T-Mobile, etc.).", "Touch Screen User Interface—The patient can be allowed to interact while inside the medical kiosk by use of a touch screen interface.", "HIPAA Compliant Design—HIPAA requires patient information to be secure.", "This will mean the medical kiosk will generally be sound proof and a passerby cannot see in and see any patient information.", "The medical kiosk generally is fully enclosed and lockable, but can allow exterior access in case of emergency.", "Instant Sterilization—Because of the many germs and other contaminants that will be inside the medical kiosk, a sterilization technology can be used in the medical kiosk.", "One type of sterilization system that can be used is a built-in sanitizing misting system that dispenses from a series of misters between every appointment.", "Another or additional sterilization system that can be used is a UV lighting system that can be blasted between appointments.", "The one or more cleaning/sanitizing systems can be used to clean the air in the medical kiosk, clean one or more surfaces of the medical kiosk (e.g., floor, bench, display screen, cabinet surfaces, chair, etc.)", "and/or a portion of all of the surfaces of a medical device.", "Other techniques and technologies can also or alternatively be used.", "The attendant can have the ability to activate one or more sterilization systems (e.g., via button, computer, etc.).", "The attendant can be required to keep track of records about the sanitization process and can ensure that the doors to the medical kiosk are closed/locked during the sterilization process.", "Video/Audio Conferencing—The patient will communicate with the medical provider via video and audio conferencing technology.", "This environment can make the patient feel as close to the medical provider as actually being present as possible.", "A two-way glass can be used to place the camera in the center of the monitor to keep the patient looking head on, versus the Skype and current video conferencing solutions that keep users looking at the camera and back to the monitor.", "Flexible Access—The medical kiosk should have a large enough door to accommodate a wheel chair.", "It should also be large enough inside to allow a parent to sit with a child and not feel constrained.", "Modular design for Pharmacy door deployment—Most Pharmacies today only have a standard door.", "The medical kiosk is built in a manner that allows it to enter through the door and quickly be assembled.", "Small Footprint—Because of the cost of retail space, the medical kiosk will be small enough to fit in most locations (e.g., 4-6 ft. wide and 7-10 ft. length).", "Fully Integrated Interior Design—The interior of the medical kiosk can be designed to be cleaner, sleeker, nicer, more luxurious, than the experience they get at the average doctor's office.", "Expandable Device Rail—The medical kiosk can include the latest medical devices and update such medical devices in a more rapid manner than the average doctors' office.", "The medical kiosk can include a mounting rail type system that allows medical devices in the medical kiosk to be easily accessed by the user.", "An indicator, such as a light, can be used to notify which medical device is to be used by the user.", "Secure PC storage with access—Because uptime of the software is so important, electronics can be inserted in a compartment in the medical kiosk.", "Such area generally should be secure, cooled, and easily accessible for service.", "Open design feels spacious—The medical kiosk is generally designed to feel bigger than it is such as by providing a glass window that wraps around the back half of the kiosk.", "Payment and Signature—The medical kiosk can include an integrated credit card swipe for payment, and a signature pad for medical authorization.", "Finger Print Reader—A finger print reader can be included on the medical kiosk to confirm patient ID under HIPAA.", "Integrated Printer—An integrated printer can be included in the medical kiosk to print medical and insurance forms and/or receipts and/or prescription.", "The printer can also print coupons based upon diagnosis to promote product sales.", "Our software can be included to inform the attendant of low paper in the paper.", "Video Playback—The recorded medical session can be partially or fully reviewed by the user to enable the user to again listen to information, instructions and/or advise from the medical provider.", "As can be appreciated, the video playback feature can also or alternatively be used for auditing purposes, compliance purposes, security purposes, quality control purposes, etc.", "Referring now to FIG.", "14, is a side view of a non-limiting embodiment of a multipurpose home and/or mobile medical device 500 that includes a plurality of medical devices.", "The size, configuration, design and materials of the mobile device are non-limiting.", "The mobile device includes a plurality of medical devices.", "The number and type of medical devices incorporated in the mobile device is non-limiting.", "As illustrated in FIG.", "14, the mobile device includes 500 with a plurality of medical devices that can be contained in a common housing.", "The multipurpose home and/or mobile medical device is designed to be simple to use.", "The mobile device illustrated in FIG.", "14 includes a stethoscope 510, an otoscope 520, a dermascope 530, an ECG 540, a thermometer 550, and a blood pressure cuff 560.As can be appreciated, the mobile device can include other or additional medical devices.", "The mobile device is generally used with a personal medical kiosk.", "The mobile device can be connected to the medical kiosk via one or more known interfaces such as, but not limited to, hard wire, USB, HDMI, Firewire, Bluetooth, IR, wireless technologies, etc.", "The mobile medical device can includes a power button 570; however, this is not required.", "The mobile device can include a USB connection 580; however, this is not required.", "The medical device can include a removable cap 590 or body portion 592; however, this is not required.", "The removable cap is illustrated as covering/protecting the otoscope or some other medical device.", "The removable body portion is illustrated as protecting and/or providing access to the dermascope or some other medical device.", "The mobile device is illustrated as including two ECG pads 542.The pads can be positioned on any region of the mobile device.", "The thermometer is illustrated as an IR thermometer; however, other types of thermometers can be used.", "The dermascope and otoscope are illustrated as being partially or fully removable from the housing of the mobile device; however, this is not required.", "The blood pressure cuff can be used to test for blood pressure and/or pulse rate of a patient.", "The blood pressure cuff is illustrated to be connected at one end to the side of the housing of the mobile device; however, this is not required.", "The blood pressure cuff is illustrated as including a Velcro connection; however, other or additional connection arrangements can be used.", "The mobile device can be designed to collect vital information and/or gather images so that a remotely located healthcare provider can be provided with such collected information and make a sound and informed diagnoses of various conditions.", "The mobile device is designed to be simple enough for a patient to use on themselves in a consultation with a medical provider.", "Referring now to FIGS.", "15-18, several medical non-limiting device panels are illustrated.", "The medical kiosk can be designed to include a medical device panel and associated software to aggregate a plurality of medical devices into a single medical device panel and software system.", "As illustrated in FIG.", "15, there is provided a medical device panel that is used to control a thermometer.", "The panel includes a button 600 to begin a temperature test.", "The panel also includes a display 602 for indicating the temperature.", "As can be appreciated, the panel can include additional information and/or functions and/or have a different configuration.", "As illustrated in FIG.", "16, there is provided a medical device panel that is used to control a blood pressure cuff.", "The panel includes a start/restart button 610 to begin the blood pressure/pulse test.", "The panel also includes displays for the pulse rate or beats per minute (bpm) 612, the systolic reading (sys) and the diastolic reading (dia) 614, 616.As can be appreciated, the panel can include additional information and/or functions and/or have a different configuration.", "Referring now to FIG.", "17, there is provided a medical device panel that includes controls for a plurality of devices.", "The device panels are a pulse oximeter 620, an otoscope and/or dermascope 630, and a stethoscope 640.As can be appreciated other or additional devices can be included on the panel.", "As also can be appreciated, individual panels can be used for each device.", "As illustrated in FIG.", "17, the pulse oximeter panel includes a start button (Take Reading) 622 for the pulse oximeter and a display for oxygen saturation percentage 624 and a display for pulse rate or beats per minute (bpm) 626.The otoscope and/or dermascope panel includes a start or Capture Image button 632 for the camera in the otoscope and/or dermascope.", "The panel also includes a camera settings button 634 which can be used to activate one or more camera setting buttons (e.g., zoom, focus, color, resolution, etc.)", "636.The panel also includes a start or Listen button 642 for the stethoscope.", "The stethoscope panel can include an amplifier or hertz selection button (e.g., 250 Hz, 1000 Hz, etc.)", "644, 646.As can be appreciated, the panels can include additional information and/or functions and/or have a different configuration.", "Referring now to FIG.", "18, there is an example of a medical device panel 650 used to control the tele-medicine medical conference.", "The panel can be used by the medical provider and/or a patient.", "As illustrated in FIG.", "18, one portion 652 of the panel is used to display or access the patient information.", "Another portion 654 of the panel is used to activate/deactivate the videoconference between the medical provider and the patient.", "Another portion 656 of the panel is used to access/activate one or more medical devices that are to be used during the tele-medicine session.", "As can be appreciated, the panel can include additional information and/or functions and/or have a different configuration.", "Referring now to FIG.", "19, there is illustrated a non-limiting medical kit 700 that includes one or more medical devices that can be used with a personal medical kiosk.", "The medical kit 700 includes a base 710 which has a plurality of compartments for holding one or more medical devices.", "The one or more compartments can also contain other materials and/or devices (e.g., band-aid, bandage, gauze, tweezers, scissors, etc.).", "The medical kit can be made of various types of materials (e.g., plastic, metal, etc.)", "The shape, size and configuration of the medical kit are non-limiting.", "The medical kit can be shaped and size to be portable; however, this is not required.", "The lid 720 of the medical kit can include a compartment 722 that is designed to removably hold a tablet computer 724, smart device, smart phone, IPad, or the like.", "As can be appreciated, the lid of the medical kit can incorporate a permanent display.", "If a tablet computer, IPad, or the like is used with the container, the tablet computer, IPad, of the like is used as the display for the personal medical kiosk.", "The camera on the tablet computer, IPad, or the like can be used to convey images to the remotely located medical provider.", "Software can be loaded into the tablet computer, IPad, or the like to interface with the remotely located medical provider, and/or the medical kit can include hardware and/or software that is used with the tablet computer, IPad, or the like.", "The one or more medical devices included in the base can be wirelessly connected or directly to the hardware and/or software of the medical kit, and/or be wirelessly connected or directly to the tablet computer, IPad, or the like.", "The medical kit can include a lock or other security arrangement to inhibit or prevent unauthorized use of the medical kit.", "The medical kit can include one or more connectors (e.g., USB, Bluetooth, Wi-Fi, etc.).", "It will thus be seen that the objects set forth above, among those made apparent from the preceding description, are efficiently attained, and since certain changes may be made in the constructions set forth without departing from the spirit and scope of the invention, it is intended that all matter contained in the above description and shown in the accompanying drawings shall be interpreted as illustrative and not in a limiting sense.", "The invention has been described with reference to preferred and alternate embodiments.", "Modifications and alterations will become apparent to those skilled in the art upon reading and understanding the detailed discussion of the invention provided herein.", "This invention is intended to include all such modifications and alterations insofar as they come within the scope of the present invention.", "It is also to be understood that the following claims are intended to cover all of the generic and specific features of the invention herein described and all statements of the scope of the invention, which, as a matter of language, might be said to fall therebetween.", "The invention has been described with reference to the preferred embodiments.", "These and other modifications of the preferred embodiments as well as other embodiments of the invention will be obvious from the disclosure herein, whereby the foregoing descriptive matter is to be interpreted merely as illustrative of the invention and not as a limitation.", "It is intended to include all such modifications and alterations insofar as they come within the scope of the appended claims." ] ]
Patent_15872546
[ [ "BIS(6-METHYL-3-SULPHOPHENYL)PHENYLPHOSPHINE, AMMONIUM SALT THEREOF, AND METHOD FOR PRODUCING SAME", "Provided are a water-soluble triarylphosphine for a palladium catalyst, which has high selectivity in a telomerization reaction and can be recovered with efficiency, an ammonium salt thereof, and a method for efficiently producing the same.", "Specifically, provided are bis(6-methyl-3-sulphophenyl)phenylphosphine; a bis(6-methyl-3-sulphonatopheyl)phenylphosphine diammonium salt obtained by reacting the phosphine with a tertiary amine having a total of 3 to 27 carbon atoms in groups bonded to one nitrogen atom; and a method for producing the same." ], [ "1-7.", "(canceled) 8: A method of performing a telomerization reaction, comprising reacting an alkadiene with water in the presence of a solid bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt, wherein the solid bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt is obtained by a process comprising: reacting bis(6-methyl-3-sulphophenyl)phenylphosphine with a tertiary amine comprising a total of 3 to 27 carbon atoms in groups bonded to one nitrogen atom.", "9.The method of claim 8, wherein the tertiary amine is at least one selected from the group consisting of trimethylamine, triethylamine, tripropylamine, triisopropylamine, tributylamine, triisobutylamine, tri-s-butylamine, tri-t-butylamine, tripentylamine, triisopentylamine, trineopentylamine, trihexylamine, triheptylamine, trioctylamine, triphenylamine, tribenzylamine, N,N-dimethylethylamine, N,N-dimethylpropylamine, N,N-dimethylisopropylamine, N,N-dimethylbutylamine, N,N-dimethylisobutylamine, N,N-dimethyl-s-butylamine, N,N-dimethyl-t-butylamine, N,N-dimethylpentylamine, N,N-dimethylisopentylamine, N,N-dimethylneopentylamine, N,N-dimethylhexylamine, N,N-dimethylheptylamine, N,N-dimethyloctylamine, N,N-dimethylnonylamine, N,N-dimethyldecylamine, N,N-dimethylundecylamine, N,N-dimethyldodecylamine, N,N-dimethylphenylamine, N,N-dimethylbenzylamine, N,N-diethylmonomethylamine, N,N-dipropylmonomethylamine, N,N-diisopropylmonomethylamine, N,N-dibutylmonomethylamine N,N-diisobutylmonomethylamine, N,N-di-s-butylmonomethylamine, N,N-di-t-butylmonomethylamine, N,N-dipentylmonomethylamine, N,N-diisopentylmonomethylamine, N,N-dineopentylmonomethylamine, N,N-dihexylmonomethylamine, N,N-diheptylmonomethylamine, N,N-dioctylmonomethylamine, N,N-dinonylmonomethylamine, N,N-didecylmonomethylamine, N,N-diundecylmonomethylamine, N,N-didodecylmonomethylamine, N,N-diphenylmonomethylamine, N,N-dibenzylmonomethylamine, N,N-dipropylmonomethylamine, N,N-diisopropylmonoethylamine, N,N-dibutylmonoethylamine, N,N-diisobutylmonoethylamine, N,N-di-s-butylmonoethylamine, N,N-di-t-butylmonoethylamine, N,N-dipentylmonoethylamine, N,N-diisopentylmonoethylamine, N,N-dineopentylmonoethylamine, N,N-dihexylmonoethylamine, N,N-diheptylmonoethylamine, N,N-dioctylmonoethylamine, N,N-dinonylmonoethylamine, N,N-didecylmonoethylamine, N,N-diundecylmonoethylamine, N,N-didodecylmonoethylamine, N,N-diphenylmonoethylamine, N,N-dibenzylmonoethylamine, and trinonylamine.", "10: the method of claim 8, wherein the tertiary amine comprises a total of 5 to 7 carbon atoms in groups bonded to one nitrogen atom.", "11: The method of claim 8, wherein the tertiary amine is at least one selected from the group consisting of triethylamine and N,N-dimethylisopropylamine.", "12: The method of claim 8, wherein the tertiary amine comprises triethylamine.", "13: The method of claim 8, wherein the alkadiene comprises butadiene.", "14: The method of claim 8, wherein the reacting of the alkadiene with water in the presence of the solid bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt produces at least one product selected from the group consisting of 2,7-octadien-1-ol, 1,7-octadien-3-ol, 1,3,6-octatriene, 1,3,7-octatriene, 2,4,6-octatriene, and 4-vinylcyclohexene.", "15: The method of claim 8, wherein the reacting of the alkadiene with water in the presence of the solid bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt produces 2,7-octadien-1-ol.", "16: The method of claim 13, wherein the reacting of the alkadiene with water in the presence of the solid bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt produces at least one product selected from the group consisting of 2,7-octadien-1-ol, 1,7-octadien-3-ol, 1,3,6-octatriene, 1,3,7-octatriene, 2,4,6-octatriene, and 4-vinylcyclohexene.", "17.The method of claim 13, wherein the reacting of the alkadiene with water in the presence of the solid bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt produces 2,7-octadien-1-ol." ], [ "<SOH> BACKGROUND ART <EOH>A palladium catalyst comprised of a phosphorous compound and a palladium compound is useful as a catalyst for a telomerization reaction between two conjugated alkadiene molecules and a nucleophilic reactant.", "Specifically, it is useful as a catalyst for production of 2,7-octadien-1-ol by reacting two butadiene molecules with one water molecule in the presence of carbon dioxide and a tertiary amine to perform a telomerization reaction.", "7-Octenal can be derived from 2,7-octadien-1-ol thus obtained by an isomerization reaction and 1,9-nonanedial can be derived from 7-octenal by a hydroformylation reaction.", "From the viewpoint that 1,9-nonanediamine which is useful as a raw material for a monomer for a polymer can be derived from 1,9-nonanedial by a reductive amination reaction, the 2,7-octadien-1-ol is of a high industrial value, and it is therefore important to develop a catalyst advantageous for the production thereof.", "In order to produce 2,7-octadien-1-ol in an industrially advantageous manner, it is preferable to recover palladium as a noble metal in the telomerization reaction and reuse it in the reaction.", "As such a method for producing 2,7-octadien-1-ol, there are two methods using a telomerization reaction, as followings: (A) a method for producing 2,7-octadien-1-ol, in which butadiene and water are subjected to a telomerization reaction in the presence of a palladium catalyst comprised of a palladium compound and a water-soluble phosphine in an aqueous sulfolane solution including a carbonate of a tertiary amine and a bicarbonate of a tertiary amine to generate 2,7-octadien-1-ol, in which at least part of the reaction mixed liquid is extracted with a saturated aliphatic hydrocarbon or the like to separate out the 2,7-octadien-1-ol by extraction, and at least a part of the sulfolane eluent including the palladium catalyst is recycled and used in the reaction (see PTLs 1 to 3), and (B) a method for producing 2,7-octadien-1-ol, in which a tertiary amine having a function as a surfactant capable of compensating for a low reaction rate due to low solubility of butadiene in water coexists therewith in a two-phase system including an aqueous phase having a palladium catalyst comprised of a palladium compound and a water-soluble phosphorus-containing compound dissolved in water and an organic phase which is butadiene, and then butadiene and water are subjected to a telomerization reaction (see PTL 4 and NPL 1).", "In the method (A), 2,7-octadien-1-ol is extracted by adding a saturated aliphatic hydrocarbon to a telomerization reaction liquid, and it is thus necessary to install equipment for distillation and recovery of the saturated aliphatic hydrocarbon, which results in an increase in cost burden associated with the equipment.", "Further, sulfolane is more expensive than ordinary hydrocarbon-based solvents, such as hexane, and accordingly, it is necessary to recover the sulfolane by subjecting the 2,7-octadien-1-ol phase obtained by extraction to washing with water, or the like.", "In addition, since sulfolane is a sulphur atom-containing substance, in a case of incineration disposal of sulfolane, an incinerator having desulphurization equipment is required.", "Therefore, there is a demand for a method for conveniently recovering most of a palladium catalyst after a telomerization reaction while not using sulfolane in the telomerization reaction.", "In the method (B), dimethyldodecyIamine, for example, is used as a tertiary amine.", "Since the dimethyldodecylamine has a function as a surfactant, complicated operations such as multiple extraction and recovery, or distillation and separation are required so as to increase the recovery of a tertiary amine.", "Further, according to Examples, it can be said that the method (B) is a method having low selectivity for 2,7-octadien-1-ol.", "Therefore, there is also a demand for a method in which the tertiary amine to be easily recovered can be used, and the selectivity for 2,7-octadien-1-ol is high.", "Moreover, as a method for producing a water-soluble triarylphosphine which can be used in a telomerization reaction, the following methods are known: (1) a method for producing a bis(3-sulphonatophenyl)phenylphosphine disodium salt, by dissolving triphenylphosphine in sulphuric acid, and then reacting the solution with sulphur trioxide in fuming sulphuric acid (see NPLs 2 and 3), (2) a method for producing a bis(3-sulphonatophenyl)phenylphosphine disodium salt by sulphonation of triphenylphosphine using an anhydrous mixture of sulphuric acid and orthoboric acid (see PTL 5), (3) a method in which triarylphosphine having an electron donating group such as a methyl group and a methoxy group in an aromatic ring is reacted with sulphur trioxide in the presence of sulphuric acid (see NPL 4), and (4) a method in which triarylphosphine having an electron donating group such as a methyl group and a methoxy group in each of three aromatic rings is reacted with sulphur trioxide in the presence of sulphuric acid (see NPL 5).", "In the case of using the alkali metal salt of a triarylphosphine having a sulphonate group, obtained by these methods, in a telomerization reaction, there is a problem in that inorganic salts such as hydrogen carbonate of an alkali metal are accumulated in the reaction system, thus blocking pipes.", "It is known that as a method to avoid this problem, it is preferable to use an ammonium salt obtained by reacting a triarylphosphine having a sulphonate group with a tertiary amine as a catalyst for a telomerization reaction (see PTL 6).", "In the method (1) for producing a water-soluble triarylphosphine, a bis(3-sulphonatophenyl)phenylphosphine disodium salt can be produced by sulphonating triphenylphosphine having a benzene ring as an equivalent aromatic ring relative to one phosphorus atom bonded thereto with sulphur trioxide, followed by neutralization with sodium hydroxide, but the yield is as low as 60%.", "This is mainly caused by by-production of a tris(3-sulphonatophenyl)phosphine trisodium salt, indicating that it is difficult to selectively introduce only “two” sulpho groups with respect to the equivalent aromatic ring.", "The method (2) for producing a water-soluble triarylphosphine is a method in which orthoboric acid is used instead of sulphur trioxide during a sulphonation reaction.", "The bis(3-sulphonatophenyl)phenylphosphine disodium salt is acquired with a yield of 94%, but in order to remove boric acid completely, toluene and triisooctylamine are added to a sulphonation reaction liquid once to cause a desired amine salt to be present in an organic phase, the organic phase is sufficiently washed with water, and the aqueous phase obtained by adding an aqueous sodium hydroxide solution to the washed organic phase is neutralized with sulphuric acid, and then concentrated.", "Then, methanol is added thereto to obtain a supernatant, from which methanol is removed, thereby acquiring a bis(3-sulphonatophenyl)phenylphosphine disodium salt.", "Although the yield is high, it is necessary to repeat washing to remove boric acid.", "Therefore, this method is difficult to carry out industrially.", "The method (3) for producing a water-soluble triarylphosphine is a method in which a triarylphosphine in which an electron donating group such as a methyl group and a methoxy group is introduced in advance to an aromatic ring is reacted with sulphur trioxide in the presence of sulphuric acid.", "Bis(4-methoxyphenyl)phenylphosphine having a non-equivalent aromatic ring, or the like is used as a raw material to acquire bis(4-methoxy-3-sulphonatophenyl)phenylphosphine disodium salt with a yield of 85%.", "Further, it can be shown that in the method (4) for producing a water-soluble triarylphosphine, a bis(6-methyl-3-sulphonatophenyl)(3-sulphonatophenyl)phosphine trisodium salt can be produced with a yield of 21% from bis(2-methylphenyl)phenylphosphine.", "However, from the viewpoint that the bis(2-methylphenyl)phenylphosphine used in the present invention has a small number of substituents such as a methyl group, as compared with bis(2,4-dimethylphenyl)phenylphosphine, the number of sulpho groups or sulphonate groups introduced tends to be 3, and therefore, there is a concern that the yield of a desired bis(6-methyl-3-sulphophenyl)phenylphosphine, and in addition, the yield of the bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt will be lowered.", "As a method for producing an ammonium salt of a triarylphosphine having a sulphonate group, methods in which for an alkali metal salt of a triarylphosphine having a sulphonate group is used as a raw material, a counter-cation is converted into a desired ammonium salt by an ion exchange process in the following manner are known.", "The methods are as follows: a method in which sulphuric acid is added to an aqueous solution of a diphenyl(3-sulphonatophenyl)phosphine sodium salt, 4-methyl-2-pentanone is then added thereto, and triethylamine is added to the obtained organic phase, thereby precipitating a solid-state diphenyl(3-sulphonatophenyl)phosphine triethylammonium salt (see PTL 6); and a method in which a diphenyl(3-sulphonatophenyl)phosphine sodium salt is pressurized with carbon dioxide in the presence of triethylamine, ethanol, and 2-propanol to acquire a desired product from a filtrate of the reaction liquid (see PTL 7)." ], [ "<SOH> SUMMARY OF INVENTION <EOH>" ], [ "TECHNICAL FIELD The present invention relates to bis(6-methyl-3-sulphophenyl)phenylphosphine, an ammonium salt thereof, and a method for producing the same.", "BACKGROUND ART A palladium catalyst comprised of a phosphorous compound and a palladium compound is useful as a catalyst for a telomerization reaction between two conjugated alkadiene molecules and a nucleophilic reactant.", "Specifically, it is useful as a catalyst for production of 2,7-octadien-1-ol by reacting two butadiene molecules with one water molecule in the presence of carbon dioxide and a tertiary amine to perform a telomerization reaction.", "7-Octenal can be derived from 2,7-octadien-1-ol thus obtained by an isomerization reaction and 1,9-nonanedial can be derived from 7-octenal by a hydroformylation reaction.", "From the viewpoint that 1,9-nonanediamine which is useful as a raw material for a monomer for a polymer can be derived from 1,9-nonanedial by a reductive amination reaction, the 2,7-octadien-1-ol is of a high industrial value, and it is therefore important to develop a catalyst advantageous for the production thereof.", "In order to produce 2,7-octadien-1-ol in an industrially advantageous manner, it is preferable to recover palladium as a noble metal in the telomerization reaction and reuse it in the reaction.", "As such a method for producing 2,7-octadien-1-ol, there are two methods using a telomerization reaction, as followings: (A) a method for producing 2,7-octadien-1-ol, in which butadiene and water are subjected to a telomerization reaction in the presence of a palladium catalyst comprised of a palladium compound and a water-soluble phosphine in an aqueous sulfolane solution including a carbonate of a tertiary amine and a bicarbonate of a tertiary amine to generate 2,7-octadien-1-ol, in which at least part of the reaction mixed liquid is extracted with a saturated aliphatic hydrocarbon or the like to separate out the 2,7-octadien-1-ol by extraction, and at least a part of the sulfolane eluent including the palladium catalyst is recycled and used in the reaction (see PTLs 1 to 3), and (B) a method for producing 2,7-octadien-1-ol, in which a tertiary amine having a function as a surfactant capable of compensating for a low reaction rate due to low solubility of butadiene in water coexists therewith in a two-phase system including an aqueous phase having a palladium catalyst comprised of a palladium compound and a water-soluble phosphorus-containing compound dissolved in water and an organic phase which is butadiene, and then butadiene and water are subjected to a telomerization reaction (see PTL 4 and NPL 1).", "In the method (A), 2,7-octadien-1-ol is extracted by adding a saturated aliphatic hydrocarbon to a telomerization reaction liquid, and it is thus necessary to install equipment for distillation and recovery of the saturated aliphatic hydrocarbon, which results in an increase in cost burden associated with the equipment.", "Further, sulfolane is more expensive than ordinary hydrocarbon-based solvents, such as hexane, and accordingly, it is necessary to recover the sulfolane by subjecting the 2,7-octadien-1-ol phase obtained by extraction to washing with water, or the like.", "In addition, since sulfolane is a sulphur atom-containing substance, in a case of incineration disposal of sulfolane, an incinerator having desulphurization equipment is required.", "Therefore, there is a demand for a method for conveniently recovering most of a palladium catalyst after a telomerization reaction while not using sulfolane in the telomerization reaction.", "In the method (B), dimethyldodecyIamine, for example, is used as a tertiary amine.", "Since the dimethyldodecylamine has a function as a surfactant, complicated operations such as multiple extraction and recovery, or distillation and separation are required so as to increase the recovery of a tertiary amine.", "Further, according to Examples, it can be said that the method (B) is a method having low selectivity for 2,7-octadien-1-ol.", "Therefore, there is also a demand for a method in which the tertiary amine to be easily recovered can be used, and the selectivity for 2,7-octadien-1-ol is high.", "Moreover, as a method for producing a water-soluble triarylphosphine which can be used in a telomerization reaction, the following methods are known: (1) a method for producing a bis(3-sulphonatophenyl)phenylphosphine disodium salt, by dissolving triphenylphosphine in sulphuric acid, and then reacting the solution with sulphur trioxide in fuming sulphuric acid (see NPLs 2 and 3), (2) a method for producing a bis(3-sulphonatophenyl)phenylphosphine disodium salt by sulphonation of triphenylphosphine using an anhydrous mixture of sulphuric acid and orthoboric acid (see PTL 5), (3) a method in which triarylphosphine having an electron donating group such as a methyl group and a methoxy group in an aromatic ring is reacted with sulphur trioxide in the presence of sulphuric acid (see NPL 4), and (4) a method in which triarylphosphine having an electron donating group such as a methyl group and a methoxy group in each of three aromatic rings is reacted with sulphur trioxide in the presence of sulphuric acid (see NPL 5).", "In the case of using the alkali metal salt of a triarylphosphine having a sulphonate group, obtained by these methods, in a telomerization reaction, there is a problem in that inorganic salts such as hydrogen carbonate of an alkali metal are accumulated in the reaction system, thus blocking pipes.", "It is known that as a method to avoid this problem, it is preferable to use an ammonium salt obtained by reacting a triarylphosphine having a sulphonate group with a tertiary amine as a catalyst for a telomerization reaction (see PTL 6).", "In the method (1) for producing a water-soluble triarylphosphine, a bis(3-sulphonatophenyl)phenylphosphine disodium salt can be produced by sulphonating triphenylphosphine having a benzene ring as an equivalent aromatic ring relative to one phosphorus atom bonded thereto with sulphur trioxide, followed by neutralization with sodium hydroxide, but the yield is as low as 60%.", "This is mainly caused by by-production of a tris(3-sulphonatophenyl)phosphine trisodium salt, indicating that it is difficult to selectively introduce only “two” sulpho groups with respect to the equivalent aromatic ring.", "The method (2) for producing a water-soluble triarylphosphine is a method in which orthoboric acid is used instead of sulphur trioxide during a sulphonation reaction.", "The bis(3-sulphonatophenyl)phenylphosphine disodium salt is acquired with a yield of 94%, but in order to remove boric acid completely, toluene and triisooctylamine are added to a sulphonation reaction liquid once to cause a desired amine salt to be present in an organic phase, the organic phase is sufficiently washed with water, and the aqueous phase obtained by adding an aqueous sodium hydroxide solution to the washed organic phase is neutralized with sulphuric acid, and then concentrated.", "Then, methanol is added thereto to obtain a supernatant, from which methanol is removed, thereby acquiring a bis(3-sulphonatophenyl)phenylphosphine disodium salt.", "Although the yield is high, it is necessary to repeat washing to remove boric acid.", "Therefore, this method is difficult to carry out industrially.", "The method (3) for producing a water-soluble triarylphosphine is a method in which a triarylphosphine in which an electron donating group such as a methyl group and a methoxy group is introduced in advance to an aromatic ring is reacted with sulphur trioxide in the presence of sulphuric acid.", "Bis(4-methoxyphenyl)phenylphosphine having a non-equivalent aromatic ring, or the like is used as a raw material to acquire bis(4-methoxy-3-sulphonatophenyl)phenylphosphine disodium salt with a yield of 85%.", "Further, it can be shown that in the method (4) for producing a water-soluble triarylphosphine, a bis(6-methyl-3-sulphonatophenyl)(3-sulphonatophenyl)phosphine trisodium salt can be produced with a yield of 21% from bis(2-methylphenyl)phenylphosphine.", "However, from the viewpoint that the bis(2-methylphenyl)phenylphosphine used in the present invention has a small number of substituents such as a methyl group, as compared with bis(2,4-dimethylphenyl)phenylphosphine, the number of sulpho groups or sulphonate groups introduced tends to be 3, and therefore, there is a concern that the yield of a desired bis(6-methyl-3-sulphophenyl)phenylphosphine, and in addition, the yield of the bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt will be lowered.", "As a method for producing an ammonium salt of a triarylphosphine having a sulphonate group, methods in which for an alkali metal salt of a triarylphosphine having a sulphonate group is used as a raw material, a counter-cation is converted into a desired ammonium salt by an ion exchange process in the following manner are known.", "The methods are as follows: a method in which sulphuric acid is added to an aqueous solution of a diphenyl(3-sulphonatophenyl)phosphine sodium salt, 4-methyl-2-pentanone is then added thereto, and triethylamine is added to the obtained organic phase, thereby precipitating a solid-state diphenyl(3-sulphonatophenyl)phosphine triethylammonium salt (see PTL 6); and a method in which a diphenyl(3-sulphonatophenyl)phosphine sodium salt is pressurized with carbon dioxide in the presence of triethylamine, ethanol, and 2-propanol to acquire a desired product from a filtrate of the reaction liquid (see PTL 7).", "CITATION LIST Patent Literature [PTL 1] JP-A-64-25739 [PTL 2] JP-A-3-232831 [PTL 3] JP-A-6-321828 [PTL 4] JP-A-8-501800 [PTL 5] JP-A-8-176167 [PTL 6] JP-A-2002-371088 [PTL 7] JP-A-2003-171388 Non Patent Literature [NPL 1] Journal of Molecular Catalysis A: Chemical, vol.97, 1995, pp.", "29 to 33 [NPL 2] Tetrahedron Letters, 2000, vol.", "41, pp.", "4503 to 4505 [NPL 3] Organic Process Research & Development, 2000, vol.", "4, pp.", "342 to 345 [NPL 4] Tetrahedron Letters, vol.", "43, 20002, pp.", "2543 to 2546 [NPL 5] Advanced Synthesis & Catalysis, 2008, vol.", "350, pp.", "609 to 618 SUMMARY OF INVENTION Technical Problem In the ion exchange method described in PTL 6, according to the investigations of the present inventors, bis(6-methyl-3-sulphophenyl)phenylphosphine was insufficiently extracted with an acyclic ketone solvent, and therefore, the yield was as low as 30% or less.", "In the ion exchange method described in PTL 7, according to the investigations of the present inventors, when the same operation was carried out using a bis(6-methyl-3-sulphonatophenyl)phenylphosphine disodium salt, the ion exchange rate of the counter-cation was as low as 20% or less.", "Therefore, it is an object of the present invention to provide a water-soluble triarylphosphine for a palladium catalyst, which has high selectivity in a telomerization reaction and is easily recovered with efficiency, and a method for efficiently producing the same efficiently.", "Solution to Problem The present inventors have conducted extensive studies, and as a result, they have found that the selectivity for desired products is increased in a telomerization reaction of two molecules of an alkadiene such as butadiene with a nucleophilic reactant such as water by using a palladium catalyst comprised of a specific ammonium salt of bis(6-methyl-3-sulphophenyl)phenylphosphine and a palladium compound.", "Further, they have also found that in the case of using the palladium catalyst in a telomerization reaction, products can be extracted from the organic phase by adding an organic solvent having a specific dielectric constant to the obtained telomerization reaction liquid, while recovery of the palladium catalyst from the aqueous phase can be carried out with high yield, thereby completing the present invention.", "That is, the present invention relates to [1] to [2] below.", "[1] Bis(6-methyl-sulphophenyl)phenylphosphine.", "[2] A bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt obtained by reacting the bis(6-methyl-3-sulphonatophenyl)phenylphosphine according to [1] with a tertiary amine having a total of 3 to 27 carbon atoms in groups bonded to one nitrogen atom.", "[3] The bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt according to [2], wherein the tertiary amine is trimethylamine, triethylamine, tripropylamine, triisopropylamine, tributylamine, triisobutylamine, tri-s-butylamine, tri-t-butylamine, tripentylamine, triisopentylamine, trineopentylamine, trihexylamine, triheptylamine, trioctylamine, triphenylamine, tribenzylamine, N,N-dimethylethylamine, N,N-dimethylpropylamine, N,N-dimethylisopropylamine, N,N-dimethylbutylamine, N,N-dimethylisobutylamine, N,N-dimethyl-s-butylamine, N,N-dimethyl-t-butylamine, N,N-dimethylbentylamine, N,N-dimethylisopentylamine, N,N-dimethylneopentylamine, N,N-dimethylhexylamine, N,N-dimethylheptylamine, N,N-dimethyloctylamine, N,N-dimethylnonylamine, N,N-dimethyldecylamine, N,N-dimethylundecylamine, N,N-dimethyldodecylamine, N,N-dimethylphenylamine, N,N-dimethylbenzylamine, N,N-diethylmonomethylamine, N,N-dipropylmonomethylamine, N,N-diisopropylmonomethylamine, N,N-dibutylmonomethylamine, N,N-diisobutylmonomethylamine, N,N-di-s-butylmonomethylamine, N,N-di-t-butylmonomethylamine, N,N-dipentylmonomethylamine, N,N-diisopentylmonomethylamine, N,N-dineopentylmonomethylamine, N,N-dihexylmonomethylamine, N,N-diheptylmonomethylamine, N,N-dioctylmonomethylamine, N,N-dinonylmonomethylamine, N,N-didecylmonomethylamine, N,N-diundecylmonomethylamine, N,N-didodecylmonomethylamine, N,N-diphenylmonomethylamine, N,N-dibenzylmonomethylamine, N,N-dipropylmonomethylamine, N,N-diisopropylmonoethylamine, N,N-dibutylmonoethylamine, N,N-diisobutylmonoethylamine, N,N-di-s-butylmonoethylamine, N,N-di-t-butylmonoethylamine, N,N-dipentylmonoethylamine, N,N-diisopentylmonoethylamine, N,N-dineopentylmonoethylamine, N,N-dihexylmonoethylamine, N,N-diheptylmonoethylamine, N,N-dioctylmonoethylamine, N,N-dinonylmonoethylamine, N,N-didecylmonoethylamine, N,N-diumdecylmonoethylamine, N,N-didodecylmonoethylamine, N,N-diphenylmonoethylamine, N,N-dibenzylmonoethylamine, or trinonylamine.", "[4] A mixture containing 90% by mole or more of Bis(6-methyl-3-sulphophenyl)phenylphosphine, and 10% by mole or less of (6-methyl-3-sulphophenyl)(2-methylphenyl)phenylphosphine.", "[5] A mixture containing 90% by mole or more of a bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt obtained by reacting the mixture according to [4] with a tertiary amine having a total of 3 to 27 carbon atoms in groups bonded to one nitrogen atom.", "[6] A method for producing bis(6-methyl-3-sulphophenyl)phenylphosphine, having: a step of reacting 2.5 moles to 4.5 moles of sulphur trioxide with 1 mole of bis(2-methylphenyl)phenylphosphine in the presence of concentrated sulphuric acid to obtain a sulphonation reaction liquid, and diluting the obtained sulphonation reaction liquid with water to obtain a diluted liquid; a step of neutralizing the diluted liquid with an alkali metal hydroxide; and a step of bringing the aqueous solution obtained in the neutralization step into contact with a strongly acidic cation exchange resin.", "[7] A method for producing a bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt by reacting bis(6-methyl-3-sulphophenyl)phenylphosphine with a tertiary amine having a total of 3 to 27 carbon atoms in groups bonded to one nitrogen atom.", "Advantageous Effects of Invention High selectivity in a telomerization reaction can be accomplished by using a water-soluble triarylphosphine for a palladium catalyst of the present invention, and the palladium catalyst after use can be efficiently recovered.", "Further, a water-soluble triarylphosphine, which will be a raw material for a palladium catalyst, can be selectively produced by the production method of the present invention.", "DESCRIPTION OF EMBODIMENTS First, in the present specification, the restrictive wording with “being preferable” can be arbitrarily adopted, and a combination of restrictive wordings with “being preferable” can be said to be more preferred.", "The present invention provides bis(6-methyl-3-sulphophenyl)phenylphosphine and an ammonium salt thereof.", "The ammonium salt thereof is more specifically a bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt.", "These can be produced efficiently by the following steps, but the invention is not particularly limited to the following steps.", "[1.Sulphonation Step] A step of reacting 2.5 moles to 4.5 moles of sulphur trioxide with 1 mole of bis(2-methylphenyl)phenylphosphine in the presence of concentrated sulphuric acid to obtain a sulphonation reaction liquid, and diluting the obtained sulphonation reaction liquid with water to obtain a diluted liquid is included.", "[2.Neutralization Step] A step of neutralizing the diluted liquid with an alkali metal hydroxide to obtain an aqueous solution including a bis(6-methyl-3-sulphonatophenyl)phenylphosphine dialkali metal salt.", "[3.Ion Exchange Step] A step of bringing the aqueous solution obtained in the neutralization step into contact with a strongly acidic cation exchange resin to for bis(6-methyl-3-sulphophenyl)phenylphosphine.", "The bis(6-methyl-3-sulphophenyl)phenylphosphine can be produced by the steps hitherto described.", "Further, for the production of a bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt, the following steps are further required.", "[4.Ammonium Salt Forming Step] A step of reacting bis(6-methyl-3-sulphophenyl)phenylphosphine with a tertiary amine having a total of 3 27 carbon atoms in groups bonded to one nitrogen atom to form a bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt.", "Furthermore, the steps will be described in detail below, but from the viewpoint that the phosphine compound is easily oxidized by oxygen, although not being clearly described, operations in the steps are carried out in an inert gas atmosphere in principle.", "Furthermore, from the same viewpoint, in the case of using a solvent, it is preferable to use a solvent having dissolved oxygen included in the solvent is purged with an inert gas.", "Examples of the inert gas include nitrogen, helium, and argon, and from the viewpoint of high industrial availability, it is preferable to use nitrogen gases.", "[1.Sulphonation Step] The method for producing bis(2-methylphenyl)phenylphosphine is not particularly limited, and the bis(2-methylphenyl)phenylphosphine can be produced according to a known method.", "For example, a reaction of dichlorophenyl phosphine with a Grignard reagent obtained from 2-bromotoluene (see Journal of Organic Chemistry, 1978, vol.", "43, pp.", "2941 to 2956) and the like are known.", "The operation sequence in the reaction of bis(2-methylphenyl)phenylphosphine with sulphur trioxide in the presence of concentrated sulphuric acid is not particularly limited, but for example, bis(2-methylphenyl)phenylphosphine can be sulphonated by dissolving bis(2-methylphenyl)phenylphosphine in concentrated sulphuric acid, followed by reaction with sulphur trioxide.", "Furthermore, sulphonation can also be carried out by the reaction with orthoboric acid instead of sulphur trioxide.", "According to the findings of the present inventors, in the case of using orthoboric acid, from the viewpoint that the removal of orthoboric acid from the sulphonation reaction liquid is complicated, it is preferable to use sulphur trioxide, and it is more preferable to use fuming sulphuric acid including sulphur trioxide and sulphuric acid.", "The sulphonation step can be carried out using a continuous stirred tank reactor equipped with a jacket.", "The continuous stirred tank reactor as mentioned herein is a reactor designed such that raw materials supplied to the reactor are mixed in a substantially homogeneous dispersion state without any delay.", "The material for the reactor is preferably stainless steel, Hastelloy C, titanium, or the like, and further, as a material for an inner wall of a reactor, a glass-lined material may be used.", "From the viewpoint of avoiding the incorporation of metal ions originating from the reactor into a desired product, it is preferable to use glass-lined materials for the inner wall.", "Further, the glass lining process is a method in which two materials, a metal and glass, are fused to perform surface modification of the metal.", "The sulphonation step can be carried out in any of a batch mode (including a semi-continuous mode) and a flow and continuous mode.", "In some cases, it can also be carried out in the flow and continuous mode by connecting two or three continuous stirred tank reactors in series.", "From the viewpoint that simplification of equipment results from dilution of a sulphonation reaction liquid with water as described later and the subsequent neutralization step, both carried out in one reaction tank, it is preferable to carry out the process in a batch mode (including a semi-continuous mode).", "Concentrated sulphuric acid serves to dissolve bis(2-methylphenyl)phenylphosphine.", "As the concentrated sulphuric acid, one having a high content of sulphuric acid is preferred, and from the viewpoint of industrial availability, one having a concentration of 96% by mass or more is more preferably used.", "A higher content of sulphuric acid in concentrated sulphuric acid is preferable since it can inhibit the hydrolysis of sulphur trioxide in fuming sulphuric acid.", "From the viewpoint that fuming sulphuric acid is more expensive than sulphuric acid, it is economically preferable to inhibit the hydrolysis of sulphur trioxide.", "Since concentrated sulphuric acid used for sulphonation is generally subjected to a disposal treatment by forming a sulphuric acid alkali metal salt by neurtalization with an alkali metal hydroxide or the like, production conditions for reducing the amount of sulphuric acid used are preferred.", "From this view point, the amount of sulphuric acid used is preferably about an amount which allows bis(2-methylphenyl)phenylphosphine to be dissolved, and more preferably an amount which adjusts the amount of bis(2-methylphenyl)phenylphosphine to be from 20% by mass to 70% by mass.", "Within this range, the amount of sulphuric acid to be disposed of can be reduced, it becomes possible to perform a reaction with sulphur trioxide in a sufficiently mixed state due to low viscosity of the prepared mixed solution, and in addition, the yield of the desired product is enhanced.", "The temperature at a time of preparation of a concentrated sulphuric acid solution of bis(2-methylphenyl)phenylphosphine is preferably from 0° C. to 100° C., and more preferably from 20° C. to 40° C. Within this range, the oxidation reaction of bis(2-methylphenyl)phenylphosphine does not proceed, it becomes possible to perform a reaction with sulphur trioxide in a sufficiently mixed state due to low viscosity of the prepared mixed solution, and in addition, the yield of the desired product is enhanced.", "Sulfur trioxide is preferably used for the reaction in the form of a fuming sulphuric acid in which sulphur trioxide is dissolved in sulphuric acid.", "The concentration of sulphur trioxide in fuming sulphuric acid is preferably from 10% by mass to 60% by mass, and more preferably from 20% by mass to 50% by mass.", "Within this range, the amount of sulphuric acid practically used can be reduced, and the time required for the sulphonation step can be shortened due to a fact that the sulphur trioxide concentration in the reaction system can be maintained at a certain level or higher.", "The amount of sulphur trioxide used is preferably from 2.5 moles to 4.5 moles, and more preferably form 3.0 moles to 4.0 moles, with respect to one mole of phosphorous atoms contained in bis(2-methylphenyl)phenylphosphine.", "Within this range, the yield of the desired product is high.", "Further, the numerical value range is a numerical value not considering the consumption by hydrolysis.", "In the case where consumption by hydrolysis is considered, it is preferable to increase the amount of sulphur trioxide used according to the amount.", "The reaction temperature for the sulphonation step is preferably from 0° C. to 100° C., more preferably from 10° C. to 50° C., and still more preferably from 20° C. to 50° C. Within this range, even in the state where the reaction time is short, the yield of a desired product is high.", "It is preferable to add fuming sulphuric acid to a concentrated sulphuric acid solution of bis(2-methylphenyl)phenylphosphine slowly, and the time taken for the addition is preferably from 0.25 hours to 5 hours, and more preferably from 0.5 hours to 3 hours.", "Within this range, the reaction time is not too long, and the yield of a desired product is high.", "Further, it is preferable that after the addition of fuming sulphuric acid, the flow path of the fuming sulphuric acid is washed with concentrated sulphuric acid, and a washing liquid thus obtained is mixed with the reaction solution.", "The reaction time after the completion of addition of fuming sulphuric acid is preferably from 2 hours to 20 hours, and more preferably from 2 hours to 8 hours.", "In the case of this range, the yield of a desired product is high.", "(Water Dilution Operation) Unreacted sulphur trioxide can be hydrolyzed by diluting the sulphonation reaction liquid obtained by the operation above with water, whereby it is possible to stop the sulphonation reaction.", "Furthermore, water used for the dilution serves to remove the dilution heat of concentrated sulphuric acid and the hydrolysis reaction heat of sulphur trioxide, and also serves as a solvent in the neutralization step of the next step.", "The temperature of water used for dilution may be any temperature at which water does not freeze, and it is preferably from 1° C. to 40° C., and more preferably from 2° C. to 25° C. Among the temperatures in this range, a lower temperature is preferred since heat can be efficiently removed.", "The amount of water used may be at least any amount in which unreacted sulphur trioxide can be hydrolyzed, but from the viewpoint of control of the temperature in the neutralization step as described later, it is from 1 time to 20 times by mass that of the sulphonation reaction liquid.", "Within this range, heat removal is easy and the amount of waste water in the neutralization step as described later can be reduced.", "The liquid temperature at the time of dilution with water is preferably from 0° C. to 100° C., and more preferably from 1° C to 40 ° C. Within this range, operations such as lowering the temperature of the liquid at a time of starting the neutralization step are not required, and thus, the productivity can be improved.", "[2.Neutralization Step] In the neutralization step, the reactor used in the sulphonation step is used as it is, and further, it is preferable to continuously carry out the step in a batch mode (including a semi-continuous mode) from the viewpoint of simplification of facilities.", "Examples of the alkali metal hydroxide used in the neutralization step include lithium hydroxide, sodium hydroxide, and potassium hydroxide.", "Among these, potassium hydroxide and sodium hydroxide are preferred, and sodium hydroxide is more preferred.", "By using the alkali metal hydroxide, a high ion exchange rate from bis(6-methyl-3-sulphonatophenyl)phenylphosphine dialkali metal salt to bis(6-methyl-3-sulphophenyl)phenylphosphine with a strongly acidic cation exchange resin can be accomplished.", "The alkali metal hydroxide may be used in the form of a solid and may be used as an aqueous solution.", "However, from the viewpoints of avoiding local heat generation at a time of neutralization and increasing the heat removal efficiency, the alkali metal hydroxide is preferably used as an aqueous solution.", "The concentration of the aqueous alkali metal hydroxide solution is not particularly limited, and the aqueous alkali metal hydroxide solution is preferably used at a concentration of 10% by mass to 50% by mass, and more preferably used at a concentration of 20% by mass to 40% by mass.", "Within this range, the liquid amount after the neutralization is low, and thus, the amount of waste water can be reduced.", "Further, it is preferable that the aqueous alkali metal hydroxide solution is slowly added to the sulphonation reaction liquid obtained in the sulphonation step, and in some cases, the aqueous alkali metal hydroxide solution can be added in several separate portions.", "Further, after using the aqueous alkali metal hydroxide solution in this concentration range, aqueous alkali metal hydroxide solutions having different concentrations, for example, an aqueous alkali metal hydroxide solution (usually an aqueous alkali metal hydroxide solution having a low concentration) having a concentration outside of the range may be used later.", "The amount of alkali metal hydroxide used is not particularly limited as long as it can neutralize sulphuric acid and bis(6-methyl-3-sulphophenyl)phenylphosphine, and it is preferably an amount such that the pH of the aqueous solution at 25° C. after the completion of neutralization is preferably from 7.0 to 9.5, and more preferably from 7.5 to 8.5.Within this range, most of a sulphuric acid can be introduced to a sulphuric acid alkali metal salt.", "Further, excess alkali metal hydroxide can be converted into water in the ion exchange step as described later.", "the neutralization temperature is not particularly limited, and usually, it is preferably from 0° C. to 40° C., and more preferably from 1° C. to 25° C. in order to promote desirable precipitation of alkali metal sulphate.", "When the neutralization temperature is 0° C. or higher, the amount of energy consumed, relevant to cooling, can be reduced, which is thus preferable.", "Further, when the neutralization temperature is 40° C. or lower, precipitation of the alkali metal sulphate during the transportation of the liquid can be inhibited, and therefore, there is no concern about pipes becoming blocked.", "The time required for the neutralization is any time as long as it is in a range suitable for the heat removal ability of a reactor used.", "Specifically, the time is preferably from 0.5 hours to 20 hours, and more preferably from 2 hours to 5 hours.", "When the time is 0.5 hours or longer, it is possible to remove neutralization heat efficiently.", "As a result, it is economically advantageous since it is not necessary to use a continuous stirred tank with high efficiency in heat removal.", "When the time is 20 hours or shorter, the increase in the amount of energy consumed for maintenance of the set temperature can be inhibited, which is thus preferable.", "The aqueous solution formed by the neutralization in the present step (hereinafter referred to as a neutralized liquid) has bis(6-methyl-3-sulphonatophenyl)phenylphosphine dialkali metal salt and an alkali metal sulphate as a main component.", "The aqueous solution formed by the neutralization in the present step (hereinafter referred to as a neutralize liquid) has bis(6-methyl-3-sulphonatophenyl)phenylphosphine dialkali metal salt and an alkali metal sulphate as a main component.", "The solubility in an alcohol such as methanol, ethanol, and 1-propanol, of the bis(6-methyl-3-sulphonatophenyl)phenylphosphine dialkali metal salt, is higher than that of the alkali metal sulphate, and thus, by using the difference in the solubility, the alkali metal sulphate can be separated out.", "Although it is possible to precipitate the alkali metal sulphate by directly adding the alcohol to the neutralized liquid, it is preferable to evaporate as much water as possible from the neutralized liquid in advance, and it is more preferable to evaporate 90% by mass to 98by mass of water in the neutralized liquid, from the viewpoints of reducing the amount of the alcohol used and inhibiting the incorporation of the alkali metal sulphate into a desired product.", "In this manner, an approach in which the alcohol is added to a concentrate obtained by evaporating water to separate out the alkali metal sulphate is preferred.", "Examples of the alcohol include methanol, ethanol, and 1-propanol, and from the viewpoint of reducing the amount of the alcohol, it is preferable to use methanol.", "The amount of the alcohol used for separating out the alkali metal sulphate is not particularly limited, and is preferably from 0.5-fold by mass to 80-fold by mass, and more preferably from 5-fold by mass to 20-fold by mass, with respect to the concentrate.", "Within this range, at a time of isolation of a desired product, the amount of the alcohol evaporated can be reduced, and further, a sufficient amount of the alkali metal salt can be precipitated.", "An insoluble material in the alcohol solution is the alkali metal sulphate, which may be separated out and removed by filtration or decantation.", "The temperature for filtration or decantation is preferably from 0° C. to 50° C., and more preferably from 1° C. to 25° C. Within this range, it is possible to precipitate only the alkali metal sulphate selectively, and thus, the yield of a desired product is high.", "In the case where the alkali metal sulphate is incorporated into the alcohol solution obtained as described above, the obtained alcohol solution may be concentrated and be dissolved in an alcohol again to repeat the operation for separation and removal the alkali metal sulphate.", "By evaporating the alcohol from the alcohol solution, it is possible to acquire a mixture of 10% by mole or less of a (6-methyl-3-sulphonatophenyl)(2-methylphenyl)phenylphosphine alkali metal salt, and 90% by mole or more of a bis(6-methyl-3-sulphonatophenyl)phenylphosphine dialkali metal salt, as a solid.", "This mixture will be hereinafter abbreviated as a mixture of alkali metal salts.", "This mixture of alkali metal salts is preferably formed of 5% by mole or less of a (6-methyl-3-sulphonatophenyl)(2-methylphenyl)phenylphosphine alkali metal salt, and 95% by mole or more of a bis(6-methyl-3-sulphonatophenyl)phenylphosphine dialkali metal salt.", "In order to increase the content of the bis(6-methyl-3-sulphonatophenyl)(phenylphosphine dialkali metal salt in the mixture of alkali metal salts, column chromatography using a mixed solvent including water, tetrahydrofuran, and the like as a mobile phase, which is passed through a column packed with silica gel, can be used.", "Alternatively, a method in which an aqueous solution of a mixture of alkali metal salts is prepared and washed with an organic solvent such as 2-butanone can also be used.", "[3.Ion Exchange Step] By reacting the mixture of alkali metal salts obtained in the neutralization step with a strongly acidic cation exchange resin, bis(6-methyl-3-sulphophenyl)phenylphosphine can be derived from the bis(6-methyl-3-sulphonatophenyl)phenylphosphine dialkali metal salt.", "According to the investigations of the present inventors, in a known method including reacting a triarylphosphine in which a counter-cation of a sulpho group is an alkali metal with a tertiary amine and carbon dioxide in the presence of an alcohol solvent, and a known method including reacting a triarylphosphine in which a counter-cation of a sulpho group is an alkali metal with a protonic acid in a solvent such as an acyclic ketone, the yield of a desired product is lowered in any case.", "Therefore, it is crucial to use a strongly acidic ion exchange resin, and according to the method, the yield of a desired product is increased.", "It is also possible to bring an alcohol solution of the mixture of alkali metal salts as it is into contact with a strongly acidic cation exchange resin, but since the solubility of the mixture of alkali metal salts in an alcohol is lower than that in water, it is preferable to bring the mixture of alkali metal salts from an aqueous solution into contact with a strongly acidic cation exchange resin to undergo a reaction.", "By using a strongly acidic cation exchange resin as a cation exchange resin, the alkali metal ions can be sufficiently converted to protons even with a small amount of the ion exchange resin.", "As the strongly acidic cation exchange resin, those in which a sulpho group is introduced to a copolymer of styrene and divinylbenzene, a copolymer of perfluorosulphonic acid and tetra fluoroethylene, and the like can be preferably used.", "Examples of the strongly acidic cation exchange resin include those which are non-aqueous and aqueous, either of which may be used.", "According to the type of a substrate, a macroporous type substrate, a gel type substrate, and the like can be mentioned, either of which may be used.", "As the strongly acidic cation exchange resin, those in which the counterion of a sulpho group contained in the resin is a proton or a sodium ion is generally known.", "In the case where the counterion is a sodium ion, the sodium ion is converted to a proton by carrying out a pre-treatment with a protonic acid such as hydrochloric acid and sulphuric acid, then the pretreated resin is used.", "In the case of a resin in which the counterion is a proton, it can be used without a pre-treatment.", "The strongly acidic cation exchange resin may have a powder shape or particulate shape, but from the viewpoint of avoiding damage due to friction in the state of use, it is preferable to use a resin having a particulate shape.", "In the case of using a resin having a particulate shape, the average particle diameter is not particularly limited, and is preferably from 0.3 mm to 3 mm, and more preferably from 0.5 mm to 1.5 mm.", "When the average particle diameter is 0.3 mm or more, it is difficult for the resin to be incorporated into a product, whereas when the average particle diameter is 3 mm or less, a large contact area of the resin with the aqueous solution of the mixture of alkali metal salts can be maintained, and as a result, the amount of the strongly acidic cation exchange resin used can be reduced.", "Examples of the strongly acidic cation exchange resin formed by introducing a sulpho group into a copolymer of styrene and divinylbenzene, which satisfies the above, include Amberlyst 15, Amberlyst 16, Amberlyst 31, Amberlyst 32, and Amberlyst 35, all manufactured by Rohm and Haas Company [in which Amberlyst is a registered trademark], Dowex 50W, Dowex 88, and Dowex G-26 [in which Dowex is a registered trademark], all manufactured by Dow Chemical Company, and Diaion SK104, Diaion SK1B, Diaion PK212, Diaion PK216, and Diaion PK228 [in which Diaion is a registered trademark], all manufactured by Mitsubishi Chemical Corporation.", "Examples of the strongly acidic cation exchange resin as a copolymer of perfluorosulphonic acid and tetrafluoroethylene include Nafion SAC-13 and Nafion NR-50 [in which Nafion is a registered trademark], both manufactured by E. I. du Pont de Nemours and Company.", "The strongly acidic cation exchange resins may be used alone or in combination of two or more kinds thereof.", "The ion exchange step can be carried out in either a flow mode or a batch mode.", "In the case of carrying out the step in a flow mode using a column, a fixed bed reactor, or the like, damage due to the friction of the strongly acidic cation exchange resin can be inhibited, and further, there is an effect that the equilibrium reaction is biased, whereby the amount of the strongly acidic cation exchange resin used can be reduced.", "From the view point of making the flow of the aqueous solution uniform, it is preferable that the reactor has a tubular structure.", "The tube diameter is not particularly limited, but it is preferably from 50 mm to 500 mm from the viewpoint of making the exchange operation of the strongly acidic cation exchange resin convenient.", "The length and number of the reactor tube as a reactor are not particularly limited, but are preferably appropriately set with the viewpoint of the production cost, strongly acidic cation exchange resin and the like, which the resin is required to achieve a desired production capacity of the reactor.", "In addition, the laminar flow may be in a down-flow mode for supplying the aqueous solution from the top of a reactor or an upflow mode for supplying from the bottom of a reactor when the reactor is a fixed bed reactor.", "The concentration of the mixture of alkali metal salts in the aqueous solution of the mixture of alkali metal salts is preferably from 1% by mass to 30% by mass, and more preferably from 5% by mass to 20% by mass.", "Within these ranges, it is possible to substitute 99% by mole or more of the alkali metals ion into a protons even with a small amount of water used.", "The temperature of the aqueous solution of the mixture of alkali metal salts is preferably from 10° C. to 120° C. If the temperature is 10° C. or higher, there is no reduction in the ion exchange rate and the increase in the amount of the strongly acidic cation exchange resin used can be avoided.", "Further, if the temperature is 120° C. or lower, the pores of the resin can be inhibited from being closed by the deformation of the ion exchange resin, and in addition, the reduction in the ion exchange rate can be inhibited.", "The of the strongly acidic cation exchange resin used preferably corresponds to 1.5 times or more the theoretical ion-exchangeable amount which is calculated from the amount of the alkali metal ions to be preliminarily exchanged.", "By this, it is possible to exchange 99% by mole or more of the alkali metal ions included in the mixture of alkali metal salts with protons.", "In addition, in the case where a higher ion exchange rate is desired, the alkali metal ions may undergo a reaction repeatedly with the strongly acidic cation exchange resin.", "The flow rate of the aqueous solution of the mixture of alkali metal salts is not particularly limited, but the liquid hourly space velocity (LHSV), a value obtained by dividing a volume velocity (m3/hr) of the aqueous solution supplied by a volume (m3) of a resin layer including the strongly acidic cation exchange resin, is preferably from 5 hr−1 to 30 hr−1, and more preferably from 10 hr−1 to 20 hr−1.within this range, the ion exchange efficiency is high.", "By evaporating water from an aqueous solution which has been brought into contact with the strongly acidic cation exchange resin, it is possible to acquire a mixture of 10% by mole or less of (6-methyl-3-sulphophenyl)(2-methylphenyl)phenylphosphine, and 90% by mole or more of bis(6-methyl-3-sulphophenyl)phenylphosphine, as a solid.", "This mixture will be hereinafter abbreviated as an ion exchanged mixture.", "The ion exchanged mixture is preferably formed of 5% by mole or less of (6-methyl-3-sulphophenyl)(2-methylphenyl)phenylphosine, and 95% by mole or more of bis(6-methyl-3-sulphophenyl)phenylphosphine.", "[4.Ammonium Salt Forming Step] It is possible to derive a corresponding ammonium salt by allowing a sulpho group included in the ion exchanged mixture obtained in the ion exchange step to undergo a reaction with the same number of moles of a tertiary amine.", "It is preferable that the ion exchanged mixture is dissolved in water, and from the viewpoint of reducing the amount of the solvent evaporated, the ion exchanged mixture is preferably used as an aqueous solution including 3% by mass to 25% by mass of the ion exchanged mixture.", "The appropriate amount of the tertiary amine can be confirmed by potentiometric titration.", "In the case of adding excess tertiary amine, the excess tertiary amine may be evaporated.", "The amount of tertiary amine used is preferably 1-fold by mole to 2-fold by mole, more preferably 1.1-fold by mole to 2-fold by mole, and still more preferably 1.1-fold by mole to 1.5-fold by mole that of the sulpho groups included in the ion exchanged mixture.", "By concentrating a solution obtained by reacting the ion exchanged mixture with the tertiary amine to dryness, a desired product as a solid can be isolated, and by evaporating a part of the water, a concentrated aqueous solution can be acquired or the solution may be used as it is.", "By directly adding the tertiary amine to the aqueous solution of the ion exchanged mixture, and sufficiently mixing them at 10° C. to 30° C. over 0.5 hours to 3 hours, the reaction with the corresponding ammonium sufficiently proceeds.", "Furthermore, as the tertiary amine, a tertiary amine having a total of 3 to 27 carbon atoms in alkyl groups bonded to one nitrogen atom is used.", "Examples of the tertiary amine include trimethylamine, triethylamine, tripropylamine, triisopropylamine, tributylamine, triisobutylamine, tri-s-butylamine, tri-t-butylamine, tripentylamine, triisopentylamine, trineopentylamine, trihexylamine, triheptylamine, trioctylamine, triphenylamine, tribenzylamine, N,N-dimethylethylamine, N,N-dimethylpropylamine, N,N-dimethylisopropylamine, N,N-dimethylbutylamine, N,N-dimethylisobutylamine, N,N-dimethyl-s-butylamine, N,N-dimethyl-t-butylamine, N,N-dimethylpentylamine, N,N-dimethylisopentylamine, N,N-dimethylneopentylamine, N,N-dimethylhexylamine, N,N-dimethylheptylamine, N,N-dimethyloctylamine, N,N-dimethylnonylamine, N,N-dimethyldecylamine, N,N-dimethylundecylamine, N,N-dimethyldodecylamine, N,N-dimethylphenylamine, N,N-dimethylbenzylamine, N,N-diethylmonomethylamine, N,N-dipropylmonomethylamine, N,N-diisopropylmonomethylamine, N,N-dibutylmonomethylamine, N,N-diisobutylmonomethylamine, N,N-di-s-butylmonomethylamine, N,N-di-t-butylmonomethylamine, N,N-dipentylmonomethylamine, N,N-diisopentylmonomethylamine, N,N-dineopentylmonomethylamine, N,N-dihexylmonomethylamine, N,N-diheptylmonomethylamine, N,N-dioctylmonomethylamine, N,N-dinonylmonomethylamine, N,N-didecylmonomethylamine, N,N-diundecylmonomethylamine, N,N-didodecylmonomethylamine, N,N-diphenylmonomethylamine, N,N-dibenzylmonomethylamine, N,N-dipropylmonomethylamine, N,N-diisopropylmonoethylamine, N,N-dibutylmonoethylamine, N,N-diisobutylmonoethylamine, N,N-di-s-butylmonoethylamine, N,N-di-t-butylmonoethylamine, N,N-dipentylmonoethylamine, N,N-diisopentylmonoethylamine, N,N-dineopentylmonoethylamine, N,N-dihexylmonoethylamine, N,N-diheptylmonoethylamine, N,N-dioctylmonoethylamine, N,N-dinonylmonoethylamine, N,N-didecylmonoethylamine, N,N-diundecylmonoethylamine, N,N-didodecylmonoethylamine, N,N-diphenylmonoethylamine, N,N-dibenzylmonoethylamine, and trinonylamine.", "These may be used alone or as a mixture of two or more kinds thereof.", "The total number of carbon atoms in groups bonded to one nitrogen atom is preferably from 3 to 24, more preferably from 5 to 24, still more preferably from 5 to 10, and particularly preferably from 5 to 7.Further, as the group bonded to one nitrogen atom, an alkyl group, an aryl group, and an aryl-substituted alkyl group are preferred, and an alkyl group is more preferred.", "Among those, as the tertiary amine, triethylamine, N,N-dimethylisopropylamine, and trioctylamine are preferred, and from the viewpoints of easy availability and production cost, triethylamine and N,N-dimethylisopropylamine are more preferred.", "By evaporating water from the reaction mixed solution after completion of the reaction, it is possible to acquire a mixture of 10% by mole or less of a (6-methyl-3-sulphonatophenyl)(2-methylphenyl)phenylphosphine ammonium salt, and 90% by mole or more of a bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt, as a solid.", "This mixture will be hereinafter abbreviated as a mixture of ammonium salts.", "The mixture of ammonium salts is preferably formed of 5% by mole or less of a (6-methyl-3-sulphonatophenyl)(2-methylphenyl)phenylphosphine ammonium salt, and 95% by mole or more of a bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt.", "In order to increase the content of the bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt in the mixture of ammonium salts, column chromatography using a mixed solvent including water, tetrahydrofuran, and the like as a mobile phase, which is passed through a column packed with silica gel, can be used.", "Alternatively, a method in which an aqueous solution of an mixture of alkali metal salts is prepared and washed with an organic solvent such as 2-butanone can also be used.", "A palladium catalyst comprised of the bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt obtained as above, or a mixture containing the same, and a palladium compound is excellent as a catalyst for a telomerization reaction.", "Examples of the telomerization reaction include a reaction in which butadiene is reacted with water in the presence of a palladium catalyst, a tertiary amine, and carbon dioxide to obtain 2,7-octadien-1-ol.", "In the telomerization reaction, the selectivity for 2,7-octadien-1-ol is improved and the recovery of the palladium catalyst is high, and therefore, the industrial availability is very high.", "Furthermore, preferred examples of the palladium compound include 0-valent palladium compounds such as bis(t-butylisonitrile)palladium(0), bis(t-amlisonitrile)palladium(0), bis(cyclohexylisonitrile)palladium(0), bis(phenylisonitrile)palladium(0), bis(p-tolylisonitrile)palladium(0), bis(2,6-dimethylphenylisonitrile)palladium(0), tris(dibenzylideneacetone) dipalladium(0), (1,5-cyclooctadiene)(maleic anhydride)palladium(0), bis(norbornene)(maleic anhydride)palladium(0), bis(maleic anhydride)(norbornene)palladium(0), (dibenzylideneacetone)(bipyridyl)palladium(0), (p-benzoquinone)(o-phenanthroline)palladium(0), tetrakis(triphenylphosphine)palladium(0), tris(triphenylphosphine)palladium(0), bis(tritolylphosphine)palladium(0), bis(trixylylphosphine)palladium(0), bis(trimesitylphosphine)palladium(0), bis(tritetramethylphenyl)palladium(0), and bis(trimethylmethoxyphenylphosphine)palladium(0); and divalent palladium compounds such as palladium (II) chloride, palladium (II) nitrate, tetraammine dichloropalladium (II), disodium tetrachloropalladium (II), palladium (II) acetate, palladium (II) benzoate, palladium (II) α-picolinate, bis(acetylacetone) palladium (II), bis(8-oxyquinoline) palladium (II), bis(allyl) palladium (II), (η-allyl) (η-cyclopentadienyl)palladium (II), (η-cyclopentadienyl)(1,5-cyclooctadiene)palladium (II) tetrafluoroborate, bis(benzonitrile)palladium (II) acetate, di-μ-chlorodichlorobis(triphenylphosphine)dipalladium (II), bis(tri-n-butylphosphine)palladium (II) acetate, and 2,2-bipyridyl palladium (II) acetate.", "Furthermore, in the case where the telomerization reaction is carried out industrially, a step of mixing the telomerization reaction liquid obtained in the telomerization reaction step with an organic solvent having a dielectric constant of 2 to 18 at 25° C., followed by performing phase separation in the presence of carbon dioxide, thereby obtaining 2,7-octadien-1-ol from an organic phase (product separation step), and a step of recovering an aqueous phase including the palladium catalyst with high efficiency (catalyst recovery step) are preferably carried out.", "At this time, in the case of using the bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt or the mixture containing the same, of the present invention, as a raw material for a palladium catalyst, the selectivity for a desired product and the recovery of the palladium catalyst are higher, as compared with other Furthermore, examples of the organic solvent having a dielectric constant of 2 to 18 at 25° C. include n-dodecane, cyclohexane, 1,4-dioxane, benzene, p-xylene, m-xylene, toluene, dibutyl ether, diisopropyl ether, propanenitrile, ethylphenyl ether, diethyl ether, methyl-t-butyl ether, cyclopentylmethyl ether, fluorobenzene, 2-methyltetrahydrofuran, tetrahydrofuran, 2-heptanone, 4-methyl-2-pentanone, cyclopentanone, 2-hexanone, 2-pentanone, cyclohexanone, 3-pentanone, and acetophenone.", "Further, the dielectric constant of the organic solvent is preferably from 3 to 10.EXAMPLES Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to such Examples in any case.", "Hereinafter, in the production of various water-soluble triarylphosphines, the production was carried out at room temperature, at normal pressure, or under a nitrogen atmosphere unless otherwise specified, and as the solvent, those which had been purged with nitrogen in advance were used.", "In addition, the water-soluble triarylphosphine obtained by sulphonating triarylphosphine may be a mixture of those in which the number of sulpho groups introduced is 1 to 3 in some case, and may further include oxides formed by oxidation of the phosphorus.", "The composition ratios (mass ratios) thereof in the water-soluble triarylphosphine were quantified from peak areas of 31P obtained by measurement using a nuclear magnetic resonance apparatus “AVANCE III 400 USPlus” (manufactured by Bruker BioSpin K. K.) with a dimethylsulphoxide-d6 (hereinafter referred to as DMSO-d6) solution prepared such that the concentration of the produced water-soluble triarylphosphine is 0.05 mol/L.", "The chemical shift of 31P in this case is a value at 305 K in the case where the chemical shift of the DMSO-d6 solution prepared to a concentration of the phosphoric acid of 0.05 mol/L is set to 0 ppm.", "Furthermore, the structure of the water-soluble triarylphosphine is determined from the chemical shifts and the peak areas of 31P and 1H obtained by measurement using a nuclear magnetic resonance apparatus “AVANCEIII 600 USPlus” (manufactured by Bruker BioSpin K. K.) with a deuterium oxide solution prepared to have a concentration of 10 mmol/L.", "The chemical shift of 31P in this case is a value at 300 K in the case where the chemical shift of a deuterium oxide solution prepared to have a concentration of the phosphoric acid of 10 mmol/L is set to 0 ppm.", "The chemical shift of 1H in this case is a value at 300 K in the case where the chemical shift of a deuterium oxide solution prepared to have a concentration of trimethylsilylpropanoic acid-d4 (hereinafter abbreviated as TSP) of 5 mmol/L is set to 0 ppm.", "Sodium ions were quantified using Ion Chromatography “ICS-1500 Type” (manufactured by Nippon Dionex K. K.).", "For the operation for purifying a desired product, a high performance liquid chromatographic system (manufactured by Nihon Waters K.K., DELTA 600 MULTI-SOLVENT Systems, 2998 Photodiode array detector, a column heater, a chromatography data software Empower1) was used.", "Further, as a reversed phase chromatography column, a “TSKgel ODS-80Ts” (particle diameter of 5 μm, inner diameter of 20 mm, and length of 250 mm) manufactured by Tosoh Corporation, was used.", "<Production of Water-Soluble Triarylphosphine> Example 1 Production of Bis(6-methyl-3-sulphophenyl)phenylphosphine A sulphonation reaction was carried out in a batch mode.", "10 g of concentrated sulphuric acid was placed in a 4-neck flask having an inner capacity of 100 ml, equipped with a thermometer, a stirring device, a dropping funnel, and a nitrogen gas line.", "The concentrated sulphuric acid was stirred, and 10.00 g (34.44 mmol in terms of phosphorous atoms) of bis(2-methylphenyl)phenylphosphine (hereinafter abbreviated as DOTPP) was introduced thereto over 0.5 hours so as to maintain the liquid temperature at 30° C. to 35° C., 35.3 g (132.3 mmol in terms of sulphur trioxide) of fuming sulphuric acid containing 30% by mass of sulphur trioxide was added dropwise thereto over 2 hours from the dropping funnel so as to maintain the same temperature.", "After completion of dropwise addition, stirring was continuously performed at a liquid temperature of 30° C. to 35° C. for 8 hours and at 20° C. to 25° C. over 15 hours.", "The liquid temperature was controlled such that it was in a range of 20° C. to 30° C., and the sulphonation reaction liquid was diluted with 90 g of ion-exchanged water.", "The aqueous phase was adjusted to have pH 8 to 9 by adding 113 g of an aqueous 30%-by-mass sodium hydroxide solution, and subsequently, 39.0 g of an aqueous 5%-by-mass sodium hydroxide solution.", "This neutralized liquid was concentrated to dryness in the range of 38° C. to 70° C. and 4 kPa to 56 kPa, and 720 g of methanol was added to the obtained concentrated solution, followed by suction-filtering, thereby obtaining a filtrate.", "This filtrate was concentrated to dryness in the range of 15° C. to 50° C. and 4 kPa to 56 kPa, thereby acquiring 16.84 g of a white solid (hereinafter abbreviated as an acquisition 1).", "A column made of glass (31 mm in diameter and 340 mm in height), packed with 100 g of a strongly acidic cation exchange resin, Dowex G-26, was prepared.", "168.4 g (16.84 g in terms of the acquisition 1 and 34.21 mmol in terms of phosphorous atoms) of an aqueous solution including 10% by mass of the acquisition 1 was allowed to pass from the upper part of the column at a linear velocity of 9.3 m/hr to 12.5 m/hr.", "This obtained liquid was concentrated to dryness in the range of 15° C., and 4 kPa to 56 kPa to acquire 14.76 g of a white solid (hereinafter abbreviated as an acquisition 2).", "According to the atomic absorption analysis of the acquisition 2, the sodium content included in the acquisition 2 was 294 ppm or less in terms of sodium atoms.", "From the viewpoint that the number of sulpho groups contained in 10.0 g of the acquisition 2 was 44.11 mmol and the content of the sodium atoms was 0.13 mmol, 99.71% by mole or more of the sulphonate groups had been converted to sulpho groups.", "The acquisition 2 was a mixture containing 0.25 g (0.68 mmol, 2.08% by mole) of (6-methyl-3-sulphophenyl)(2-methylphenyl)phenylphosphine, and 14.51 g (32.20 mmol, 97.92% by mole) of bis(6-methyl-3-sulphophenyl)phenylphosphine.", "From the viewpoint that 14.76 g (32.89 mmol in terms of phosphorous atoms) of the acquisition 2 could be acquired by using 10.00 g (34.44 mmol in terms of phosphorous atoms) of DOTPP, the yield based on the phosphorous atoms was 95.5%.", "Example 2 Purification of Bis(6-methyl-3-sulphophenyl)phenylphosphine Using a high performance liquid chromatographic system equipped with a reversed phase chromatography column, a mixed liquid including 70% by mass of water and 30% by mass of acetonitrile as a mobile phase was passed through the system at 5.0 mL/minute in the state where a column oven temperature was controlled such that it was 40° C. 1 g of an aqueous solution including 1% by mass of the acquisition 2 of Example 1 was prepared, and injected.", "The photodiode array detector was set to 275 nm and a distillate with a retention time of 15 minutes to 30 minutes was recovered.", "This operation was repeated 10 times.", "The collected distillate was concentrated to dryness in the range of 35° C. to 70° C. and 4 kPa to 56 kPa to acquire 45.5 mg of bis(6-methyl-3-sulphophenyl)phenylphosphine as a white solid.", "31P-NMR (600 MHz, 300 K, deuterium oxide, phosphoric acid, ppm) δ: −17.44 (s) 1H-NMR (600 MHz, 300 K, deuterium oxide, TSP, ppm) δ: 2.34 (s, 6 H), 7.24 (dd, 2.1 Hz, 1.7 Hz, 2 H), 7.33 (t, 7.9 Hz, 2 H), 7.37 to 7.46 (m, 4 H), 7.49 (t, 7.2 Hz, 1 H), 7.79 dd, 1.3 Hz, 2 H) From the viewpoint that 45.5 mg (0.101 mmol in terms of phosphorous atoms) of a desired product could be acquired by using 100.0 mg (0.223 mmol in terms of phosphorous atoms) of the acquisition 2, the yield based on the phosphorous atoms in the purification was 45.3%.", "Example 3 Production of Bis(6-methyl-3-sulphonatophenyl)phenylphosphine Di(triethylammonium) Salt An aqueous solution including the acquisition 2 was acquired in the same manner as in Example 1, and 7.5 g (74.3 mmol) of triethylamine was added thereto, followed by stirring the mixture in the range of 20° C. to 30° C. over 1 hour, to carry out a reaction.", "Thereafter, the reaction liquid was concentrated to dryness in the range of 35° C. to 70° C. and 4 kPa to 56 kPa, thereby acquiring 21.21 g of a pale yellow solid.", "31P-NMR (400 MHz, 305 K, DMSO-d6, phosphoric acid, ppm) δ: a (6-methyl-3-sulphonatophenyl)(2-methylphenyl)phenylphosphine triethylammonium salt showed a peak at −19.81 (s), and a bis(6-methyl-3-sulphonatophenyl)phenylphosphine di(triethylammonium) salt showed a peak at −17.02 (s).", "The acquisition was mixture containing 0.32 g (0.69 mmol, 2.10% by mole) of a (6-methyl-3-sulphonatophenyl)(2-methylphenyl)phenylphosphine triethylammonium salt, and 20.89 g (31.99 mmol, 97.90% by mole) of a bis(6-methyl-3-sulphonatophenyl)phenylphosphine di(triethylammonium salt.", "From the viewpoint that 21.21 g (32.68 mmol in terms of phosphorous atoms) of a desired product could be acquired from 10.00 g (34.44 mmol in terms of phosphorous atoms) of DOTPP, the yield based on the phosphorous atoms was 94.0%.", "Example 4 Production of Bis(6-methyl-3-sulphonatophenyl)phenylphosphine Di(tri-n-octylammonium) Salt An aqueous solution including the acquisition 2 was acquired in the same manner as in Example 1, and 26.28 g (74.3 mmol) of tri-n-octylamine was added thereto, followed by stirring the mixture in the range of 20° C. to 30° C. over 1 hour, to carry out a reaction.", "Thereafter, the reaction liquid was concentrated to dryness in the range of 35° C. to 70° C. and 4 kPa to 56 kPa, thereby acquiring 37.18 g of a pale yellow solid.", "31P-NMR (400 MHz, 305 K, DMSO-d6, phosphoric acid, ppm) δ: a (6-methyl-3-sulphonatophenyl)(2-methylphenyl)phenylphosphine tri-n-octyl ammoniumammonium salt showed a peak at −20.39 (s), and a bis(6-methyl-3-sulphonatophenyl)phenylphosphine di(tri-n-octylammonium) salt showed a peak at −17.20 (s).", "The acquisition was a mixture containing 0.50 g (0.70 mmol, 2.15% by mole) of a (6-methyl-3-sulphonatophenyl)(2-methylphenyl)phenylphosphine tri-n-octylammonium salt, and 36.68 g (31.68 mmol, 97.85% by mole) of a bis(6-methyl-3-sulphonatophenyl)phenylphosphine di(tri-n-octylammonium) salt.", "From the viewpoint that 37.18 g (32.37 mmol in terms of phosphorous atoms) of a desired product could be acquired from 10.00 g (34.44 mmol in terms of phosphorous atoms) of DOTPP, the yield based on the phosphorous atoms was 94.0%.", "<Telomerization Reaction> Hereinafter, it is shown that the water-soluble triarylphosphine of the present invention is useful for a telomerization reaction with reference to Reference Examples.", "Further, the present invention is not limited to such Reference Examples in any case.", "Moreover, the concentrations of the palladium compounds and the phosphorus compounds included in the aqueous phase acquired by an extraction operation were quantified by subjecting a wet decomposition product to analysis using a polarized Zeeman atomic absorption spectrophotometer “Z-5300 Type” (manufactured by Hitachi, Ltd.).", "In addition, organic materials such as a tertiary amine and 2,7-octadien-1-ol included in the telomerization reaction liquid or the aqueous phase including the palladium catalyst were analyzed and quantified by gas chromatography under the following measurement conditions.", "(Analysis Conditions for Gas Chromatography) Apparatus: GC-14 A (Manufactured by Shimadzu Corporation) Column used: G-300 (1.2 mm in internal diameter×20 m in length, and a film thickness of 2 μm), (Materials) manufactured by Chemicals Evaluation, and Research Institute, Japan Analysis conditions: an inlet temperature of 220° C, and a detector temperature of 220° C. Sample injection amount: 0.4 μL Carrier gas: helium (260 kPa) is flowed at 10 mL/minute.", "Column temperature: maintained at 60° C. for 5 minutes→raised at 10° C./minute→maintained at 220° C. for 9 minutes Detector: hydrogen flame ionization detector (FID) Reference Example 1 The telomerization reaction was carried out in a batch mode.", "A 3 L autoclave equipped with an SUS316 electromagnetic induction stirring device including a 96 mL pressure container made of glass, for pumping a palladium catalyst, a 96 mL pressure container made of glass, for pumping a solvent, and a sampling port was used as a reactor.", "Further, the reaction was carried out at a stirring rotation speed of 500 rpm, and from the viewpoint that the reaction results at this time were not different from those at 1,000 rpm, a sufficient stirring state could be achieved.", "17.69 g of a tetrahydrofuran solution including 94.74 mg (0.422 mmol in terms of palladium atoms) of palladium (II) acetate, and then 21.46 g of an aqueous solution including 1.370 g (2.109 mmol in terms of trivalent phosphorous atoms) of the phosphorous compound obtained in Example 3 were introduced into a pressure container made of glass and stirred for 60 minutes to prepare a palladium catalyst liquid.", "30.06 g of distilled water, 80.10 g of triethylamine, 97.50 g of 2,7-octadien-1-ol, and 114.95 g (2.13 mol) of butadiene were put into the autoclave, followed by stirring at 500 rpm in a closed system and warming to 70° C. Thereafter, the palladium catalyst liquid was pumped from the pressure container made of glass through carbon dioxide within 10 seconds, while the total pressure was set to 1.2 MPa (gauge pressure).", "Further, a time point at which pumping of the palladium catalyst liquid was completed was defined as 0 hours at initiation of reaction.", "In addition, the ratio of the trivalent phosphorus atoms to the palladium atoms at a time of preparation of a catalyst was 5.00, and in the telomerization reaction, the amount of the palladium atoms with respect to 1 mol of butadiene was 0.198 mmol, the mass ratio of triethylamine to water was 1.55, and the mass ratio of a mixture of butadiene and 2,7-octadien-1ol to water was 4.12.For the telomerization reaction liquid after a predetermined reaction time, the product was quantified by gas chromatography analysis.", "The conversion of the butadiene was calculated by the following Equation 1.Further, the respective units in the equations are mol.", "Butadiene conversion (%)=100×{1−(Amount of butadiene in reaction liquid/Amount of butadiene introduced)} [Equation 1] Examples of the respective products include 2,7-octadien-1-ol, 1,7-octadien-3-ol, 1,3,6-octatriene, 1,3,7-octatriene, 2,4,6-octatriene, and 4-vinylcyclohexene.", "However, 1,3,6-octatriene, 1,3,7-octatriene, and 2,4,6-octatriene are collectively referred to as octatrienes.", "The selectivities of the respective products were calculated by the following Equation 2.Further, the respective units in the equations are mol.", "Selectivity for each product (%)=50×(Amount of each product in reaction liquid/Amount of butadiene reacted) [Equation 2] The selectivities for high-boiling-point products which could not be sufficiently quantified by gas chromatography were calculated by the following Equation 3.Further, the respective units in the equations are mol.", "Selectivity for high-boiling-point products (%)=100−(Total sum of selectivities of the respective products, calculated by Equation 2) [Equation 3] After 8 hours of the reaction, the butadiene conversion was 77.9%, the selectivity for 2,7-octadien-1-ol was 88.7%, the selectivity for 1,7-octadien-3-ol was 7.4%, the selectivity for octatrienes was 2.1%, and the selectivity for the high-boiling-point products was 1.8%.", "Further, the selectivity for 4-vinylcyclohexene was 0.01% or less.", "The autoclave was cooled to 25° C., and a reaction consumption-equivalent amount of water and 330.23 g (a volume at 25° C. of 463.2 mL) of diethyl ether were pumped through carbon dioxide, using a 96 mL pressure container made of glass, for pumping a solvent.", "The mixture was stirred for 1 hour while being pressurized to a total pressure of 3 MPa (gauge pressure) with carbon dioxide.", "This mixed liquid was transferred to a pressure container equipped with a glass window, which had been pressurized to 3 MPa (gauge pressure) with carbon dioxide using a pump, to carry out phase separation.", "The aqueous phase was suitably recovered into a pressure container made of glass, which had been pressurized to 1 MPa (gauge pressure) with carbon dioxide, connected to a pressure container equipped with a glass window.", "The pressure container made of glass was taken out, separated, and opened at normal pressure, and the weight of the aqueous phase was measured, while the acquired aqueous phase was used for various types of analysis.", "In addition, the mass ratio of diethyl ether to the telomerization reaction liquid was 0.84.The content of palladium included in the aqueous phase was calculated from the concentration of palladium as demonstrated by the analysis with a polarized Zeeman atomic absorption spectrophotometer using a wet decomposition product of the aqueous phase and the weight of the recovered aqueous phase.", "The recovery of the palladium atoms was calculated by the following Equation 4.Further, the units of the respective amounts in the equation are mol.", "Recovery of palladium atoms (%)=(Amount of palladium in aqueous phase/Amount of palladium introduced)×100 [Equation 4] The content of phosphorous included in the aqueous phase was calculated from the concentration of phosphorous as demonstrated by the analysis with a polarized Zeeman atomic absorption spectrophotometer using a wet decomposition product of the aqueous phase and the weight of the recovered aqueous phase.", "The recovery of the water-soluble triarylphosphine was calculated by the following Equation 5.Further, the units of the respective amounts in the equation are mol.", "Recovery of water-soluble triarylphosphine (%)=100×(Amount of phosphorous atoms in aqueous phase/Amount of phosphorous atoms introduced) [Equation 5] The tertiary amine included in the aqueous phase was quantified by analyzing the aqueous phase using gas chromatography.", "The recovery of the tertiary amine was calculated by the following Equation 6.Further, the units of the respective amounts in the equations are mol.", "Recovery of tertiary amine (%)=100×(Amount of tertiary amine in aqueous phase/Amount of tertiary amine introduced) [Equation 6] The recovery of the palladium atoms into the aqueous phase was 91.3%, the recovery of phosphorous atoms was 90.9%, and the recovery of triethylamine was 83.0%.", "Further, the amount of diethyl ether incorporated into the aqueous phase was 0.1% by mass or less.", "Reference Example 2 (Comparative) The same operation as in Reference Example 1 except that 2.120 g (2.120 mmol in terms of trivalent phosphorous atoms) of a diphenyl(3-sulphonatophenyl)phosphine triethylammonium salt (with the provision that it included 4.40% by mole of oxides) was used instead of the phosphorous compound obtained in Example 3 was carried out.", "Further, the ratio of the trivalent phosphorous atoms to the palladium atoms at a time of preparation of the catalyst was 5.02.After 4 hours of the reaction, the butadiene conversion was 77.6%, the selectivity for 2,7-octadien-1-ol was 88.2%, the selectivity for 1,7-octadien-3-ol was 5.1%, the selectivity for octatrienes was 5.1%, and the selectivity for the high-boiling-point products was 1.6%.", "Further, the selectivity for 4-vinylcyclohexene was 0.01% or less.", "The recovery of the palladium atoms into the aqueous phase was 28.2%, the recovery of phosphorous atoms was 48.8%, and the recovery of triethylamine was 65.5%.", "Further, the amount of diethyl ether incorporated into the aqueous phase was 0.1% by mass or less.", "Reference Example 3 (Comparative) The same operation as in Reference Example 1 except that 1.015 g (2.113 mmol in terms of trivalent phosphorous atoms) of a diphenyl(6-methyl-3-sulphonatophenyl)phosphine triethylammonium salt (with the provision that it included 4.58% by mole of oxides was used instead of the phosphorous compound obtained in Example 3 was carried out.", "Further, the ratio of the trivalent phosphorous atoms to the palladium atoms at a time of preparation of the catalyst was 5.01.After 4 hours of the reaction, the butadiene conversion was 85.0%, the selectivity for 2,7-octadien-1-ol was 88.8%, the selectivity for 1,7-octadien-3-ol was 5.0%, the selectivity for octatrienes was 4.4%, and the selectivity for the high-boiling-point products was 1.8%.", "Further, the selectivity for 4-vinylcyclohexene was 0.01% or less.", "The recovery of the palladium atoms into the aqueous phase was 12.0%, the recovery of phosphorous atoms was 28.3%, and the recovery of triethylamine was 76.5%.", "Further, the amount of diethyl ether incorporated into the aqueous phase was 0.1% by mass or less.", "According to Example 1, it is apparent that a mixture of 5% by mole or less of (6-methyl-3-sulphophenyl)(2-methylphenyl)phenylphosine, and 95% by mole or more of bis(6-methyl-3-sulphophenyl)phenylphosphine can be acquired with high yield.", "Furthermore, according to Example 2, it is apparent that bis(6-methyl-3-sulphophenyl)phenylphosphine can be isolated and purified by column chromatography.", "According to Examples 3 and 4, it is apparent that a bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt can be acquire with high yield by reacting bis(6-methyl-3-sulphophenyl)phenylphosphine with a tertiary amine having a total of 3 to 27 carbon atoms in groups bonded to one nitrogen atom.", "According to Reference Examples 1 to 3, it is apparent that the bis(6-methyl-3-sulphonatophenyl)Phenylphosphine diammonium salt provided by the present invention can be obtained with higher selectivity in the telomerization reaction and the recovery of the palladium catalyst is higher, as compared with other water-soluble triarylphosphines, and therefore, it is useful when carrying out industrial telomerization reactions.", "INDUSTRIAL APPLICABILITY The bis(6-methyl-3-sulphonatophenyl)phenylphosphine diammonium salt obtained by using bis(6-methyl-3-sulphonatophenyl)phenylphosphine of the present invention is useful for a telomerization reaction of two molecules of an alkadiene such as butadiene with a nucleophilic reactant such as water." ] ]
Patent_15872550
[ [ "METHOD AND APPARATUS FOR TISSUE GRAFTING AND COPYING", "Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided.", "For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube.", "Micrografts can be harvested and directly implanted into an overlying biocompatible matrix through coordinated motion of the tube and pin.", "A needle can be provided around the tube to facilitate a direct implantation of a micrograft into a remote recipient site or matrix.", "The exemplary apparatus can include a plurality of such tubes and pins for simultaneous harvesting and/or implanting of a plurality of micrografts.", "The harvested micrografts can have a small dimension, e.g., less than about 1 mm, which can promote healing of the donor site and/or viability of the harvested tissue." ], [ "1.A system for obtaining a plurality of portions of tissue from a biological tissue, comprising: a plurality of tubes coupled to a base, each tube of the plurality comprising at least two points provided at a distal end thereof; a plurality of pins each provided at least partially within a central lumen of each of the plurality of tubes; a vibrating arrangement coupled to the base configured to cause the plurality of tubes to vibrate and facilitate the insertion of the tubes into the biological tissue, wherein at least one section of the tubes is structured to be inserted into the biological tissue at the donor site to simultaneously remove the portions of tissue therefrom when the at least one section of the tubes is withdrawn from the donor site, and wherein the pins are configured to facilitate a removal of the portions of tissue from the tubes.", "2.The system of claim 1, wherein an inner diameter of the tubes is less than about 1 mm.", "3.The system of claim 1, wherein an inner diameter of the tubes is less than about 0.5 mm.", "4.The system of claim 1, wherein at least one of the plurality of tubes comprises at least three points provided at the distal end thereof.", "5.The system of claim 1, further comprising at least one positioning arrangement configured to control a position of at least one of the plurality of pins within at least one of the plurality of tubes.", "6.The system of claim 1, further comprising an actuator configured to control a position of at least one of the plurality of pins within at least one of the plurality of tubes.", "7.The system of claim 1, wherein at least one of the plurality of pins is controllably translatable in a direction along a longitudinal axis of the plurality of tubes.", "8.The system of claim 1, wherein the plurality of tubes comprises at least six tubes.", "9.The system of claim 8, wherein the tubes are provided in at least one of a rectangular array or a linear configuration with respect to one another.", "10.The system of claim 1, further comprising at least one sensor arrangement configured to detect a presence of the portion of tissue within at least one of the plurality of tubes.", "11.The system of claim 1, wherein an angle between a lateral side of the points and a longitudinal axis of at least one of the plurality of tubes is less than about 15 degrees.", "12.The system of claim 1, wherein the vibrating arrangement has an amplitude of vibration of between 50 μm and 500 μm, and a frequency of vibrations between 10 Hz and 10 kHz.", "13.The system of claim 12, wherein the vibrating arrangement includes circuitry configured to adjust the amplitude and frequency of the vibrations.", "14.The system of claim 1, wherein the system further comprises a biocompatible matrix configured to be placed on a donor site associated with the biological tissue and configured to receive at least one portion of the portions of tissue from the biological tissue.", "15.The system of claim 14, wherein the biocompatible matrix comprises at least one of polyactic acid, collagen, low-melting agarose, hyaluronic acid, hyaluranon, or devitalized skin tissue.", "16.The system of claim 15, wherein the biocompatible matrix further a nutrient, a growth factor, or a combination thereof.", "17.The system of claim 1, wherein at least a portion of a surface of the pins comprises a low-friction material.", "18.A method for obtaining at least one portion of at least one biological tissue, comprising: positioning a distal end of at least one hollow tube proximal to a donor tissue site; positioning a pin within a lumen of the at least one tube such that the distal end of the pin is proximal to the distal end of the at least one tube; advancing the at least one tube into the donor site to sever the at least one portion of the at least one biological tissue from the donor tissue site, wherein the at least one tube is coupled to a base comprising a vibrating arrangement; actuating the vibrating arrangement to cause the at least one tube to vibrate to facilitate the insertion of the tubes into the biological tissue; and raising the at least one tube from the donor site, such that the at least one portion of the at least one biological tissue is removed from the donor site.", "19.The method of claim 18, further comprising providing a matrix material over the donor tissue site.", "20.A method for harvesting and implanting at least one portion of at least one biological tissue, comprising: positioning a distal end of at least one hollow tube proximal to an upper surface of the at least one biological tissue; positioning a pin within a lumen of the at least one tube such that the distal end of the pin is provided at a predetermined distance behind the distal end of the at least one tube; advancing the at least one tube into the at least one biological tissue to sever the at least one portion of the at least one biological tissue from a surrounding tissue, such that the distal end of the pin is positioned is proximal to the upper surface of the at least one biological tissue, wherein the at least one tube is coupled to a base, actuating a vibrating arrangement coupled to the base to cause the at least one tube to vibrate; raising the at least one tube and the pin simultaneously until the at least one tube is removed from the at least one biological tissue, wherein the at least one portion of the at least one biological tissue remains within the at least one tube; inserting a hollow needle into a recipient material to a particular depth; providing the at least one hollow tube containing the at least one portion of the at least one biological tissue in a lumen of the hollow needle, such that a distal end of the hollow tube is proximal to the distal end of the at least one hollow tube; retracting the hollow needle from the recipient material while maintaining a location of the at least one hollow tube within the recipient material; and withdrawing the at least one hollow tube from the recipient material while maintaining a location of the pin substantially stationary relative to the recipient material, such that the at least one portion of the at least one biological tissue remains within the recipient material.", "21.The method of claim 20, wherein the recipient material comprises at least one of a biologically compatible matrix or a further biological tissue." ], [ "<SOH> BACKGROUND INFORMATION <EOH>An autograft can refer to tissue transplanted from one part of an individual's body (e.g., a “donor site”) to another part (e.g., a “recipient site”).", "Autografts can be used, for example, to replace missing skin and other tissue and/or to accelerate healing resulting from trauma, wounds, burns, surgery and birth defects.", "Availability of tissue for autografting can be limited by characteristics of candidate donor sites, including a number and/or total area of tissue grafts, healing behavior of the donor site, similarity of the donor and recipient sites, aesthetic considerations, etc.", "Skin grafting can be performed surgically.", "For example, a conventional autograft procedure may include excision or surgical removal of burn injured tissue, choosing a donor site, which may be an area from which healthy skin is removed to be used as cover for the cleaned burned area, and harvesting, where the graft may be removed from the donor site, e.g., using an instrument similar to an electric shaver.", "Such instrument (e.g., a dermatome) can be structured to gently shave a piece of tissue, which may be, e.g., about 10/1000 of an inch thick for a split-thickness graft, from the skin at the unburned donor site to use as a skin graft.", "The skin graft can then be placed over the cleaned wound so that it can heal.", "Donor skin tissue can be removed to such a depth that the donor site can heal on its own, in a process similar to that of healing of a second degree burn.", "Two conventional types of autografts which may be used for a permanent wound coverage include sheet grafts and meshed grafts.", "A sheet graft can refer to a piece of skin tissue removed from an undamaged donor site of the body, in a process that may be referred to as harvesting.", "The size of the donor skin piece that is used may be about the same size as the damaged area.", "The sheet graft can be applied over the excised wound, and stapled or otherwise fastened in place.", "The donor skin tissue used in sheet grafts may not stretch significantly, and a sheet graft can be obtained that is slightly larger than the damaged area to be covered because there may often be a slight shrinkage of the graft tissue after harvesting.", "Sheet grafts can provide an improved appearance of the repaired tissue site.", "For example, sheet grafts may be used on large areas of the face, neck and hands if they are damaged, so that these more visible parts of the body can appear less scarred after healing.", "A sheet graft may be used to cover an entire burned or damaged region of skin, e.g., if the damaged site is small.", "Small areas of a sheet graft can be lost after placement because of a buildup of fluid (e.g., a hematoma) can occur under the sheet graft following placement the sheet graft.", "Sheet grafts may be full-thickness or split-thickness.", "For example, split-thickness skin grafts can be used to cover wounds in burn and skin ulcer patients.", "A conventional split-thickness graft can be formed, e.g., by harvesting a sheet of epidermis and upper dermal tissue from a donor site, in a procedure similar to that of peeling an apple.", "The split-thickness graft can then be placed on the location of the burn or ulcer.", "The skin tissue may then grow back at the donor site following a generally extended healing time.", "Split-thickness grafts may be preferable to full-thickness grafts because removing large amounts of full-thickness skin tissue from the donor site can lead to scarring and extensive healing times at the donor site, as well as an increased risk of infection.", "However, skin tissue removed from the donor site for a split-thickness skin autograft can include only a thin epithelial layer, which can lack certain elements of the dermis that improve structural stability and normal appearance in the recipient site.", "Full-thickness skin grafts can be formed using sheets of tissue that include the entire epidermis layer and a dermal component of variable thickness.", "Because the dermal component can be preserved in full-thickness grafts, more of the characteristics of normal skin can be maintained following the grafting procedure.", "Full-thickness grafts can contain a greater collagen content, dermal vascular plexus, and epithelial appendages as compared to split-thickness grafts.", "However, full-thickness grafts can require more precise conditions for survival because of the greater amount of tissue requiring revascularization.", "Full-thickness skin grafts can be preferable for repairing, e.g., visible areas of the face that may be inaccessible by local flaps, or for graft procedures where local flaps are contraindicated.", "Such full-thickness skin grafts can retain more of the characteristics of normal skin including, e.g., color, texture, and thickness, as compared to split-thickness grafts.", "Full-thickness grafts may also undergo less contraction while healing.", "These properties can be important on more visible areas such as the face and hands.", "Additionally, full-thickness grafts in children can be more likely to grow with the individual.", "However, the application of conventional full-thickness skin grafts can be limited to relatively small, uncontaminated, well-vascularized wounds, and thus may not be appropriate for as many types of graft procedures as split-thickness grafts.", "Additionally, donor sites for full-thickness grafts can require surgical closure or resurfacing with a split-thickness graft.", "A meshed skin graft can be used to cover larger areas of open wounds that may be difficult to cover using sheet grafts because of, e.g., a lack of a sufficient area of healthy donor sites.", "Meshing of a skin graft can facilitate skin tissue from a donor site to be expanded to cover a larger area.", "It also can facilitate draining of blood and body fluids from under the skin grafts when they are placed on a wound, which may help prevent graft loss.", "The expansion ratio (e.g., a ratio of the unstretched graft area to the stretched graft area) of a meshed graft may typically be between about 1:1 to 1:4.For example, donor skin can be meshed at a ratio of about 1:1 or 1:2 ratio, whereas larger expansion ratios may lead to a more fragile graft, scarring of the meshed graft as it heals, and/or extended healing times.", "A conventional graft meshing procedure can include running the donor skin tissue through a machine that cuts slits through the tissue, which can facilitate the expansion in a pattern similar to that of fish netting or a chain-link fence.", "Healing can occur as the spaces between the mesh of the stretched graft, which may be referred to as gaps or interstices, fill in with new epithelial skin growth.", "However, meshed grafts may be less durable graft than sheet grafts, and a large mesh can lead to permanent scarring after the graft heals.", "To help the graft heal and become secure, the area of the graft can preferably be made immobile (e.g., not moved) for at least about five days following each surgery.", "During this immobilization period, blood vessels can grow from underlying tissue into the skin graft, and can help to bond the two tissue layers together.", "About five days after the graft is placed, exercise therapy programs, tub baths, and other normal daily activities can often be resumed.", "Deep second-degree and full-thickness burns may require skin graft surgery for quick healing and minimal scarring.", "Large burn sizes can lead to more than one grafting procedure during a hospital stay, and may require long periods of immobilization for healing.", "As an alternative to autografting, skin tissue obtained from recently-deceased people (which may be referred to, e.g.", "as a homograft, an allograft, or cadaver skin) can be used as a temporary cover for a wound area that has been cleaned.", "Unmeshed cadaver skin can be put over the excised wound and stapled in place.", "Post-operatively, the cadaver skin may be covered with a dressing.", "Wound coverage using cadaveric allograft can then be removed prior to permanent autografting.", "A xenograft or heterograft can refer to skin taken from one of a variety of animals, for example, a pig.", "Heterograft skin tissue can also be used for temporary coverage of an excised wound prior to placement of a more permanent autograft, and may be used because of a limited availability and/or high expense of human skin tissue.", "In some cases religious, financial, or cultural objections to the use of human cadaver skin may also be factors leading to use of a heterograft.", "Wound coverage using a xenograft or an allograft is generally a temporary procedure which may be used until harvesting and placement of an autograft is feasible.", "Epithelial appendages can be regenerated following a grafting procedure.", "For example, hair can be more likely to grow from full-thickness grafts than from split-thickness grafts, but such hair growth may be undesirable based on the location of the wound.", "Accordingly, donor sites for full-thickness grafts can be carefully selected based in part, e.g., on patterns of hair growth at the time of surgery.", "Further, certain hair follicles may not be oriented perpendicular to the skin surface, and they can be transected if an incision provided to remove graft tissue is not oriented properly.", "Sweat glands and sebaceous glands located in graft tissue may initially degenerate following grafting.", "These structures can be more likely to regenerate in full-thickness grafts than in split-thickness grafts because full-thickness grafts can be transferred as entire functional units.", "For example, sweat gland regeneration can depend in part on reinnervation of the skin graft with recipient bed sympathetic nerve fibers.", "Once such ingrowth has occurred, the skin graft can assume the sweating characteristics of the recipient site, rather than retaining the characteristics of the donor site.", "In contrast, sebaceous gland regeneration may be independent of graft reinnervation and can retain the characteristics of the donor site.", "Prior to the regeneration, the skin graft tissue may lack normal lubrication of sebum produced by these glands, which can make such grafts more susceptible to injury.", "In general, grafting procedures may be limited by the amount of tissue which can be removed from the donor site without causing excessive adverse effects.", "Full-thickness grafts can provide improved tissue quality at the wound site, but the donor site may be more severely disfigured as described above.", "Split-thickness grafts can be a compromise between healing times and aesthetic and functional properties of the donor and recipient sites, whereas meshing can provide more extensive graft coverage at the expense of visible scarring.", "Harvesting of the graft tissue from the donor site can generally generate undesirable large-scale tissue damage to the donor site.", "On the other hand, small areas of skin wounding adjacent to healthy tissue can be well-tolerated, and may heal quickly.", "Such healing of small wounds can occur in techniques such as “fractional photothermolysis” or “fractional resurfacing,” in which patterns of damage having a small dimension can be created in skin tissue.", "These exemplary techniques are described, e.g., in U.S. Pat.", "No.", "6,997,923 and U.S. Patent Publication No.", "2006/0155266.Small-scale damage patterns can heal quickly by regrowth of healthy tissue, and can further provide desirable effects such as skin tightening without visible scarring.", "In view of the shortcomings of the above described procedures for tissue grafting, it may be desirable to provide exemplary embodiments of method and apparatus that can provide tissue suitable for grafting, e.g., while minimizing unwanted damage to the donor sites." ], [ "<SOH> SUMMARY OF EXEMPLARY EMBODIMENTS <EOH>Exemplary embodiments of the present disclosure provide method and apparatus for obtaining small portions of graft tissue that can be accompanied by rapid healing of the donor site.", "For example, the exemplary embodiment of the method can be provided for obtaining skin graft tissue by harvesting small portions of the tissue, e.g., micrografts, from a donor site.", "Such micrografts can be used to form grafts or “copy” tissue to generate larger tissue structures from the small tissue samples.", "Such micrografts can comprise skin tissue that can include, e.g., epidermal and dermal tissue, and/or tissue obtained from other body organs.", "The micrografts can have at least one dimension that is relatively small, e.g., less than about 1 mm, or less than about 0.5 mm, or optionally about 0.3 mm or less, or about 0.2 mm.", "Such exemplary small dimensions of the micrografts can facilitate both healing of the donor site following harvesting and viability of the micrografts by allowing greater diffusional nourishment of the micrograft tissue.", "The small regions of damage in the donor site caused by a removal of the tissue portions can heal rapidly with little or no formation of visible scars.", "The micrografts obtained from skin tissue can include, e.g., epidermal and dermal tissue, and can also include stem cells that can be located proximal to the dermal/fatty layer boundary.", "The micrografts can also be obtained from other types of tissue, e.g., various internal organs or the like.", "A fraction of dermal tissue that is removed from a donor site can be, e.g., less than about 70%, or less than about 50%, although other fractions may be used.", "The harvested tissue portions can be in the shape of cylinders, elongated strips, or other geometries which can include at least one small dimension.", "In certain exemplary embodiments, a portion of the tissue at the donor site may be frozen or partially frozen.", "Such freezing may facilitate cutting, removal and/or viability of the harvested tissue portions.", "In a further exemplary embodiment of the present disclosure, an apparatus for harvesting micrografts can be provided that includes at least one hollow tube with a pin provided at least partially within the tube, wherein the pin is controllably translatable in a direction along the longitudinal axis of the tube.", "The diameter of the pin can be substantially the same as the internal diameter of the lumen of the tube, or it can be slightly smaller.", "Such tube(s) and corresponding pin(s) can be mechanically coupled to a substrate having at least one hole therethrough.", "A plurality of linear actuators can be provided to controllably position and/or move the at least one tube and pin relative to the substrate.", "For example, the actuators can be configured to position the at least one tube through a hole in the substrate and control a distance that the distal end of the tube protrudes from a lower surface of the substrate.", "The actuators can further be configured to independently control the position of the pin within the tube.", "The substrate can be configured to be positioned on the surface of a tissue to facilitate harvesting of micrografts from the tissue and/or implantation of micrografts into the tissue.", "In further exemplary embodiments of the present disclosure, a plurality of tubes and corresponding pins can be provided to facilitate harvesting of a plurality of micrografts.", "A plurality of actuators or mechanical arrangements can be provided in communication with the proximal ends of the tubes and/or pins to facilitate precise positioning and translation of the plurality of tubes and pins relative to each other and to the tissue.", "The actuators can be configured to translate all of the tubes and/or pins simultaneously, or optionally to translate certain ones of the tubes or pins independently of the other tubes.", "A vibrating arrangement can be coupled to the apparatus to facilitate the insertion of the tubes into the donor and/or recipient site.", "The exemplary micrografts can be placed in a biocompatible matrix, e.g., to form a graft or larger copy of the donor tissue, or may be implanted directly into tissue at the recipient site.", "The biocompatible matrix can be formed using collagen, polylactic acid, hyaluronic acid, and/or other substances which can support the harvested micrograft tissue portions and promote their growth.", "The matrix can optionally include, e.g., nutrients, growth factors, and/or other substances to promote tissue growth or viability.", "The harvested tissue portions can be bonded to the matrix using techniques such as photochemical tissue bonding to provide structural stability.", "The matrix can then be applied to the recipient site, which can promote growth and revascularization of the tissue portions to form a continuous sheet of the grafted tissue.", "Optionally, the matrix can be placed in a suitable environment to facilitate growth of the micrografts therein, which can then form a larger portion of tissue ‘copied’ from the donor site.", "The exemplary micrografts can also be gathered in a compact configuration to form graft tissue that can be applied directly to a recipient site.", "The exemplary micrografts can also be inserted directly into the tissue at a recipient site such as, e.g., scar tissue, using, e.g., the exemplary hollow tubes described herein.", "In certain exemplary embodiments, the micrografts can be harvested from a donor site tissue that is different from the tissue type at the recipient site to form various types of heterografts.", "Still further exemplary embodiments of the present disclosure can provide methods for extracting or harvesting micrografts from a tissue and optionally place them directly in a matrix material.", "For example, such exemplary methods can utilize an exemplary apparatus that includes at least one tube and pin provided therein to harvest tissue as follows: A) A portion or sheet of a matrix material can be placed on a donor tissue site, and the distal ends of the tube and pin provided within the tube can each be positioned proximal to the upper surface of the matrix.", "B) The tube and pin can be translated together to penetrate through the matrix and be positioned proximal to the surface of the donor site.", "C) The tube can then be translated downward into the tissue of the donor site to sever a portion of the tissue from the surrounding tissue, while the distal end of the pin remains at the surface of the donor site.", "D) The tube and pin can then be retracted simultaneously until the distal end of the tube is proximal to the lower surface of the matrix material or within the matrix material, and a micrograft comprising the severed tissue remains within the distal portion of the tube.", "E) The tube can then be further retracted from the matrix while the pin location is held substantially stationary relative to the matrix, such that the micrograft is held within the matrix material by the stationary pin and remains within the matrix as the tube is retracted from around the micrograft.", "In yet another exemplary embodiment of the present disclosure, a piercing needle can be provided around at least a portion of the hollow tube and pin.", "The apparatus including at least one hollow tube, pin, and piercing needle can be configured to place a micrograft contained within a distal portion of the hollow tube into tissue located at a recipient site.", "The piercing needle can be inserted into tissue at a recipient site.", "The hollow tube containing the pin and a harvested micrograft in the distal portion thereof can be advanced through the piercing tube such that the distal end of the hollow tube is proximal to or below the surface of the recipient site.", "The piercing needle can be withdrawn from the recipient site, while the hollow tube is held stationary.", "The hollow tube can then be withdrawn while holding the pin within the tube stationary relative to the recipient site.", "In this manner, the micrograft can remain within the tissue of the recipient site, e.g., held there by the pin as the hollow tube is withdrawn.", "The pin can subsequently be withdrawn to leave the micrograft within the recipient site where the tissue was initially separated by the piercing needle.", "A substrate can be provided with at least one opening therethrough and configured to be placed on the tissue surface, to facilitate positioning of the needle, tube and/or pin relative to the tissue being treated and/or to facilitate mechanical stabilization of the tissue during treatment.", "These and other objects, features and advantages of the present disclosure will become apparent upon reading the following detailed description of exemplary embodiments of the present disclosure, when taken in conjunction with the appended claims." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation application of U.S. application Ser.", "No.", "14/711,936 filed on May 14, 2015, which is a divisional application of U.S. patent application Ser.", "No.", "13/102,711 filed May 6, 2011 which claims the benefit of U.S.", "Provisional Patent Application Ser.", "No.", "61/332,230 filed May 7, 2010, U.S.", "Provisional Patent Application Ser.", "No.", "61/373,498 filed Aug. 13, 2010, and U.S.", "Provisional Patent Application Ser.", "No.", "61/437,507 filed Jan. 28, 2011, the disclosures of which are incorporated herein by reference in their entireties.", "FIELD OF THE DISCLOSURE The present disclosure relates to exemplary embodiments of method and apparatus for providing tissue grafts and reproducing tissue structures using tissue, e.g., from a donor site.", "BACKGROUND INFORMATION An autograft can refer to tissue transplanted from one part of an individual's body (e.g., a “donor site”) to another part (e.g., a “recipient site”).", "Autografts can be used, for example, to replace missing skin and other tissue and/or to accelerate healing resulting from trauma, wounds, burns, surgery and birth defects.", "Availability of tissue for autografting can be limited by characteristics of candidate donor sites, including a number and/or total area of tissue grafts, healing behavior of the donor site, similarity of the donor and recipient sites, aesthetic considerations, etc.", "Skin grafting can be performed surgically.", "For example, a conventional autograft procedure may include excision or surgical removal of burn injured tissue, choosing a donor site, which may be an area from which healthy skin is removed to be used as cover for the cleaned burned area, and harvesting, where the graft may be removed from the donor site, e.g., using an instrument similar to an electric shaver.", "Such instrument (e.g., a dermatome) can be structured to gently shave a piece of tissue, which may be, e.g., about 10/1000 of an inch thick for a split-thickness graft, from the skin at the unburned donor site to use as a skin graft.", "The skin graft can then be placed over the cleaned wound so that it can heal.", "Donor skin tissue can be removed to such a depth that the donor site can heal on its own, in a process similar to that of healing of a second degree burn.", "Two conventional types of autografts which may be used for a permanent wound coverage include sheet grafts and meshed grafts.", "A sheet graft can refer to a piece of skin tissue removed from an undamaged donor site of the body, in a process that may be referred to as harvesting.", "The size of the donor skin piece that is used may be about the same size as the damaged area.", "The sheet graft can be applied over the excised wound, and stapled or otherwise fastened in place.", "The donor skin tissue used in sheet grafts may not stretch significantly, and a sheet graft can be obtained that is slightly larger than the damaged area to be covered because there may often be a slight shrinkage of the graft tissue after harvesting.", "Sheet grafts can provide an improved appearance of the repaired tissue site.", "For example, sheet grafts may be used on large areas of the face, neck and hands if they are damaged, so that these more visible parts of the body can appear less scarred after healing.", "A sheet graft may be used to cover an entire burned or damaged region of skin, e.g., if the damaged site is small.", "Small areas of a sheet graft can be lost after placement because of a buildup of fluid (e.g., a hematoma) can occur under the sheet graft following placement the sheet graft.", "Sheet grafts may be full-thickness or split-thickness.", "For example, split-thickness skin grafts can be used to cover wounds in burn and skin ulcer patients.", "A conventional split-thickness graft can be formed, e.g., by harvesting a sheet of epidermis and upper dermal tissue from a donor site, in a procedure similar to that of peeling an apple.", "The split-thickness graft can then be placed on the location of the burn or ulcer.", "The skin tissue may then grow back at the donor site following a generally extended healing time.", "Split-thickness grafts may be preferable to full-thickness grafts because removing large amounts of full-thickness skin tissue from the donor site can lead to scarring and extensive healing times at the donor site, as well as an increased risk of infection.", "However, skin tissue removed from the donor site for a split-thickness skin autograft can include only a thin epithelial layer, which can lack certain elements of the dermis that improve structural stability and normal appearance in the recipient site.", "Full-thickness skin grafts can be formed using sheets of tissue that include the entire epidermis layer and a dermal component of variable thickness.", "Because the dermal component can be preserved in full-thickness grafts, more of the characteristics of normal skin can be maintained following the grafting procedure.", "Full-thickness grafts can contain a greater collagen content, dermal vascular plexus, and epithelial appendages as compared to split-thickness grafts.", "However, full-thickness grafts can require more precise conditions for survival because of the greater amount of tissue requiring revascularization.", "Full-thickness skin grafts can be preferable for repairing, e.g., visible areas of the face that may be inaccessible by local flaps, or for graft procedures where local flaps are contraindicated.", "Such full-thickness skin grafts can retain more of the characteristics of normal skin including, e.g., color, texture, and thickness, as compared to split-thickness grafts.", "Full-thickness grafts may also undergo less contraction while healing.", "These properties can be important on more visible areas such as the face and hands.", "Additionally, full-thickness grafts in children can be more likely to grow with the individual.", "However, the application of conventional full-thickness skin grafts can be limited to relatively small, uncontaminated, well-vascularized wounds, and thus may not be appropriate for as many types of graft procedures as split-thickness grafts.", "Additionally, donor sites for full-thickness grafts can require surgical closure or resurfacing with a split-thickness graft.", "A meshed skin graft can be used to cover larger areas of open wounds that may be difficult to cover using sheet grafts because of, e.g., a lack of a sufficient area of healthy donor sites.", "Meshing of a skin graft can facilitate skin tissue from a donor site to be expanded to cover a larger area.", "It also can facilitate draining of blood and body fluids from under the skin grafts when they are placed on a wound, which may help prevent graft loss.", "The expansion ratio (e.g., a ratio of the unstretched graft area to the stretched graft area) of a meshed graft may typically be between about 1:1 to 1:4.For example, donor skin can be meshed at a ratio of about 1:1 or 1:2 ratio, whereas larger expansion ratios may lead to a more fragile graft, scarring of the meshed graft as it heals, and/or extended healing times.", "A conventional graft meshing procedure can include running the donor skin tissue through a machine that cuts slits through the tissue, which can facilitate the expansion in a pattern similar to that of fish netting or a chain-link fence.", "Healing can occur as the spaces between the mesh of the stretched graft, which may be referred to as gaps or interstices, fill in with new epithelial skin growth.", "However, meshed grafts may be less durable graft than sheet grafts, and a large mesh can lead to permanent scarring after the graft heals.", "To help the graft heal and become secure, the area of the graft can preferably be made immobile (e.g., not moved) for at least about five days following each surgery.", "During this immobilization period, blood vessels can grow from underlying tissue into the skin graft, and can help to bond the two tissue layers together.", "About five days after the graft is placed, exercise therapy programs, tub baths, and other normal daily activities can often be resumed.", "Deep second-degree and full-thickness burns may require skin graft surgery for quick healing and minimal scarring.", "Large burn sizes can lead to more than one grafting procedure during a hospital stay, and may require long periods of immobilization for healing.", "As an alternative to autografting, skin tissue obtained from recently-deceased people (which may be referred to, e.g.", "as a homograft, an allograft, or cadaver skin) can be used as a temporary cover for a wound area that has been cleaned.", "Unmeshed cadaver skin can be put over the excised wound and stapled in place.", "Post-operatively, the cadaver skin may be covered with a dressing.", "Wound coverage using cadaveric allograft can then be removed prior to permanent autografting.", "A xenograft or heterograft can refer to skin taken from one of a variety of animals, for example, a pig.", "Heterograft skin tissue can also be used for temporary coverage of an excised wound prior to placement of a more permanent autograft, and may be used because of a limited availability and/or high expense of human skin tissue.", "In some cases religious, financial, or cultural objections to the use of human cadaver skin may also be factors leading to use of a heterograft.", "Wound coverage using a xenograft or an allograft is generally a temporary procedure which may be used until harvesting and placement of an autograft is feasible.", "Epithelial appendages can be regenerated following a grafting procedure.", "For example, hair can be more likely to grow from full-thickness grafts than from split-thickness grafts, but such hair growth may be undesirable based on the location of the wound.", "Accordingly, donor sites for full-thickness grafts can be carefully selected based in part, e.g., on patterns of hair growth at the time of surgery.", "Further, certain hair follicles may not be oriented perpendicular to the skin surface, and they can be transected if an incision provided to remove graft tissue is not oriented properly.", "Sweat glands and sebaceous glands located in graft tissue may initially degenerate following grafting.", "These structures can be more likely to regenerate in full-thickness grafts than in split-thickness grafts because full-thickness grafts can be transferred as entire functional units.", "For example, sweat gland regeneration can depend in part on reinnervation of the skin graft with recipient bed sympathetic nerve fibers.", "Once such ingrowth has occurred, the skin graft can assume the sweating characteristics of the recipient site, rather than retaining the characteristics of the donor site.", "In contrast, sebaceous gland regeneration may be independent of graft reinnervation and can retain the characteristics of the donor site.", "Prior to the regeneration, the skin graft tissue may lack normal lubrication of sebum produced by these glands, which can make such grafts more susceptible to injury.", "In general, grafting procedures may be limited by the amount of tissue which can be removed from the donor site without causing excessive adverse effects.", "Full-thickness grafts can provide improved tissue quality at the wound site, but the donor site may be more severely disfigured as described above.", "Split-thickness grafts can be a compromise between healing times and aesthetic and functional properties of the donor and recipient sites, whereas meshing can provide more extensive graft coverage at the expense of visible scarring.", "Harvesting of the graft tissue from the donor site can generally generate undesirable large-scale tissue damage to the donor site.", "On the other hand, small areas of skin wounding adjacent to healthy tissue can be well-tolerated, and may heal quickly.", "Such healing of small wounds can occur in techniques such as “fractional photothermolysis” or “fractional resurfacing,” in which patterns of damage having a small dimension can be created in skin tissue.", "These exemplary techniques are described, e.g., in U.S. Pat.", "No.", "6,997,923 and U.S. Patent Publication No.", "2006/0155266.Small-scale damage patterns can heal quickly by regrowth of healthy tissue, and can further provide desirable effects such as skin tightening without visible scarring.", "In view of the shortcomings of the above described procedures for tissue grafting, it may be desirable to provide exemplary embodiments of method and apparatus that can provide tissue suitable for grafting, e.g., while minimizing unwanted damage to the donor sites.", "SUMMARY OF EXEMPLARY EMBODIMENTS Exemplary embodiments of the present disclosure provide method and apparatus for obtaining small portions of graft tissue that can be accompanied by rapid healing of the donor site.", "For example, the exemplary embodiment of the method can be provided for obtaining skin graft tissue by harvesting small portions of the tissue, e.g., micrografts, from a donor site.", "Such micrografts can be used to form grafts or “copy” tissue to generate larger tissue structures from the small tissue samples.", "Such micrografts can comprise skin tissue that can include, e.g., epidermal and dermal tissue, and/or tissue obtained from other body organs.", "The micrografts can have at least one dimension that is relatively small, e.g., less than about 1 mm, or less than about 0.5 mm, or optionally about 0.3 mm or less, or about 0.2 mm.", "Such exemplary small dimensions of the micrografts can facilitate both healing of the donor site following harvesting and viability of the micrografts by allowing greater diffusional nourishment of the micrograft tissue.", "The small regions of damage in the donor site caused by a removal of the tissue portions can heal rapidly with little or no formation of visible scars.", "The micrografts obtained from skin tissue can include, e.g., epidermal and dermal tissue, and can also include stem cells that can be located proximal to the dermal/fatty layer boundary.", "The micrografts can also be obtained from other types of tissue, e.g., various internal organs or the like.", "A fraction of dermal tissue that is removed from a donor site can be, e.g., less than about 70%, or less than about 50%, although other fractions may be used.", "The harvested tissue portions can be in the shape of cylinders, elongated strips, or other geometries which can include at least one small dimension.", "In certain exemplary embodiments, a portion of the tissue at the donor site may be frozen or partially frozen.", "Such freezing may facilitate cutting, removal and/or viability of the harvested tissue portions.", "In a further exemplary embodiment of the present disclosure, an apparatus for harvesting micrografts can be provided that includes at least one hollow tube with a pin provided at least partially within the tube, wherein the pin is controllably translatable in a direction along the longitudinal axis of the tube.", "The diameter of the pin can be substantially the same as the internal diameter of the lumen of the tube, or it can be slightly smaller.", "Such tube(s) and corresponding pin(s) can be mechanically coupled to a substrate having at least one hole therethrough.", "A plurality of linear actuators can be provided to controllably position and/or move the at least one tube and pin relative to the substrate.", "For example, the actuators can be configured to position the at least one tube through a hole in the substrate and control a distance that the distal end of the tube protrudes from a lower surface of the substrate.", "The actuators can further be configured to independently control the position of the pin within the tube.", "The substrate can be configured to be positioned on the surface of a tissue to facilitate harvesting of micrografts from the tissue and/or implantation of micrografts into the tissue.", "In further exemplary embodiments of the present disclosure, a plurality of tubes and corresponding pins can be provided to facilitate harvesting of a plurality of micrografts.", "A plurality of actuators or mechanical arrangements can be provided in communication with the proximal ends of the tubes and/or pins to facilitate precise positioning and translation of the plurality of tubes and pins relative to each other and to the tissue.", "The actuators can be configured to translate all of the tubes and/or pins simultaneously, or optionally to translate certain ones of the tubes or pins independently of the other tubes.", "A vibrating arrangement can be coupled to the apparatus to facilitate the insertion of the tubes into the donor and/or recipient site.", "The exemplary micrografts can be placed in a biocompatible matrix, e.g., to form a graft or larger copy of the donor tissue, or may be implanted directly into tissue at the recipient site.", "The biocompatible matrix can be formed using collagen, polylactic acid, hyaluronic acid, and/or other substances which can support the harvested micrograft tissue portions and promote their growth.", "The matrix can optionally include, e.g., nutrients, growth factors, and/or other substances to promote tissue growth or viability.", "The harvested tissue portions can be bonded to the matrix using techniques such as photochemical tissue bonding to provide structural stability.", "The matrix can then be applied to the recipient site, which can promote growth and revascularization of the tissue portions to form a continuous sheet of the grafted tissue.", "Optionally, the matrix can be placed in a suitable environment to facilitate growth of the micrografts therein, which can then form a larger portion of tissue ‘copied’ from the donor site.", "The exemplary micrografts can also be gathered in a compact configuration to form graft tissue that can be applied directly to a recipient site.", "The exemplary micrografts can also be inserted directly into the tissue at a recipient site such as, e.g., scar tissue, using, e.g., the exemplary hollow tubes described herein.", "In certain exemplary embodiments, the micrografts can be harvested from a donor site tissue that is different from the tissue type at the recipient site to form various types of heterografts.", "Still further exemplary embodiments of the present disclosure can provide methods for extracting or harvesting micrografts from a tissue and optionally place them directly in a matrix material.", "For example, such exemplary methods can utilize an exemplary apparatus that includes at least one tube and pin provided therein to harvest tissue as follows: A) A portion or sheet of a matrix material can be placed on a donor tissue site, and the distal ends of the tube and pin provided within the tube can each be positioned proximal to the upper surface of the matrix.", "B) The tube and pin can be translated together to penetrate through the matrix and be positioned proximal to the surface of the donor site.", "C) The tube can then be translated downward into the tissue of the donor site to sever a portion of the tissue from the surrounding tissue, while the distal end of the pin remains at the surface of the donor site.", "D) The tube and pin can then be retracted simultaneously until the distal end of the tube is proximal to the lower surface of the matrix material or within the matrix material, and a micrograft comprising the severed tissue remains within the distal portion of the tube.", "E) The tube can then be further retracted from the matrix while the pin location is held substantially stationary relative to the matrix, such that the micrograft is held within the matrix material by the stationary pin and remains within the matrix as the tube is retracted from around the micrograft.", "In yet another exemplary embodiment of the present disclosure, a piercing needle can be provided around at least a portion of the hollow tube and pin.", "The apparatus including at least one hollow tube, pin, and piercing needle can be configured to place a micrograft contained within a distal portion of the hollow tube into tissue located at a recipient site.", "The piercing needle can be inserted into tissue at a recipient site.", "The hollow tube containing the pin and a harvested micrograft in the distal portion thereof can be advanced through the piercing tube such that the distal end of the hollow tube is proximal to or below the surface of the recipient site.", "The piercing needle can be withdrawn from the recipient site, while the hollow tube is held stationary.", "The hollow tube can then be withdrawn while holding the pin within the tube stationary relative to the recipient site.", "In this manner, the micrograft can remain within the tissue of the recipient site, e.g., held there by the pin as the hollow tube is withdrawn.", "The pin can subsequently be withdrawn to leave the micrograft within the recipient site where the tissue was initially separated by the piercing needle.", "A substrate can be provided with at least one opening therethrough and configured to be placed on the tissue surface, to facilitate positioning of the needle, tube and/or pin relative to the tissue being treated and/or to facilitate mechanical stabilization of the tissue during treatment.", "These and other objects, features and advantages of the present disclosure will become apparent upon reading the following detailed description of exemplary embodiments of the present disclosure, when taken in conjunction with the appended claims.", "BRIEF DESCRIPTION OF THE DRAWINGS Further objects, features and advantages of the present disclosure will become apparent from the following detailed description taken in conjunction with the accompanying figures showing illustrative embodiments, results and/or features of the exemplary embodiments of the present disclosure, in which: FIG.", "1A is a schematic illustration of an exemplary donor site after cylindrical portions of micrograft tissue have been harvested therefrom; FIG.", "1B is a schematic illustration of the exemplary donor site shown in FIG.", "1A after healing has occurred; FIG.", "1C is a schematic illustration of an exemplary micrograft that can be removed from the exemplary donor site shown in FIG.", "1A; FIG.", "2A is a cross-sectional view of an exemplary graft prepared by providing harvested micrograft tissue portions in a biocompatible matrix; FIG.", "2B is a cross-sectional view of the exemplary graft shown in FIG.", "2A after it has been placed over a wound and some regrowth has occurred; FIG.", "3A is a schematic illustration of another exemplary donor site after elongated strips of tissue have been harvested therefrom; FIG.", "3B is a schematic illustration of the exemplary donor site shown in FIG.", "3A after healing has occurred; FIG.", "3C is a schematic illustration of an exemplary tissue strip that may be removed from the donor site shown in FIG.", "3A; FIG.", "4A is a schematic view in plan of a plurality of exemplary cylindrical micrograft tissue portions provided in a compact arrangement to form a graft; FIG.", "4B is a side view of the exemplary micrograft tissue portions shown in FIG.", "4A; FIG.", "5A is a schematic illustration of an exemplary apparatus that can be used to harvest micrograft tissue in accordance with further exemplary embodiments of the present disclosure; FIG.", "5B is a schematic illustration of the exemplary apparatus that can be used to harvest the micrograft tissue in accordance with further exemplary embodiments of the present disclosure; FIG.", "6A is a schematic illustration of the exemplary apparatus shown in FIG.", "5A that is inserted into an exemplary donor site to harvest an exemplary micrograft; FIG.", "6B is a schematic illustration of the exemplary apparatus shown in FIG.", "5A that contains the harvested micrograft; FIG.", "6C is a schematic illustration of the exemplary apparatus shown in FIG.", "5A showing the harvested micrograft being removed therefrom; FIG.", "7 is a schematic illustration of the exemplary apparatus that can be used to harvest micrograft tissue in accordance with further exemplary embodiments of the present disclosure; FIG.", "8A is an exemplary image of a distal end of the exemplary apparatus that includes two points; FIG.", "8B is a further exemplary image of the distal end of the exemplary apparatus shown in FIG.", "8A; FIGS.", "8C and 8D are exemplary schematic illustrations of exemplary geometric parameters that can be associated with the shape of the distal end of the exemplary apparatus shown in FIG.", "8A; FIGS.", "8E-8J are exemplary schematic illustrations of various exemplary geometric configurations that can be provided for the distal end of the exemplary apparatus shown in FIG.", "8A; FIG.", "9 is an exemplary image of the micrografts obtained using the exemplary apparatus shown in FIG.", "8A; FIG.", "10A is a schematic illustration of a portion of an exemplary apparatus that can be used to harvest a micrograft tissue in accordance with further exemplary embodiments of the present disclosure; FIG.", "10B is an illustration of the portion of the exemplary apparatus shown in FIG.", "10A; FIG.", "11 is a schematic illustration of an exemplary apparatus that can be used to harvest the micrograft tissue in accordance with still further exemplary embodiments of the present disclosure; FIG.", "12 is a schematic illustration of an exemplary sequence of procedures that can be used to the harvest micrograft tissue in accordance with further exemplary embodiments of the present disclosure; FIG.", "13A is a schematic illustration of an exemplary configuration of a stabilizing substrate that can be used to harvest the micrograft tissue in accordance with further exemplary embodiments of the present disclosure; FIG.", "13B is an exemplary image of a further exemplary configuration of a stabilization substrate in accordance with yet further exemplary embodiments of the present disclosure; FIG.", "14 is a schematic illustration of an exemplary configuration of an arrangement that includes two stabilizing substrates that can be used to harvest the micrograft tissue in accordance with additional exemplary embodiments of the present disclosure; and FIGS.", "15A-15E are schematic illustrations of an exemplary apparatus and procedure for placing harvested micrographs directly into tissue at a recipient site; FIG.", "16 is a series of exemplary images of a micrograft harvested from pig skin placed in a collagen gel matrix using the exemplary apparatus and/or method according to exemplary embodiments of the present disclosure; FIG.", "17 is a series of exemplary images of micrografts harvested from a black mouse and implanted in a wound formed in a nude mouse using the exemplary apparatus and/or method according to exemplary embodiments of the present disclosure; FIG.", "18A is an exemplary image of a full-thickness skin wound formed in a swine subject; FIG.", "18B is a series of exemplary images showing healing progress of an exemplary wound as shown in FIG.", "18A with and without implanted micrografts; FIG.", "19A is a series of illustrations showing an exemplary sequence of insertion and extraction of an exemplary apparatus from a biological tissue using the exemplary apparatus and/or method according to exemplary embodiments of the present disclosure; and FIG.", "19B is a plot of exemplary displacement and force data as a function of time corresponding to the exemplary insertion and extraction sequence shown in FIG.", "19A.", "Throughout the drawings, the same reference numerals and characters, unless otherwise stated, are used to denote like features, elements, components, or portions of the illustrated embodiments.", "Moreover, while the present disclosure will now be described in detail with reference to the figures, it is done so in connection with the illustrative embodiments and is not limited by the particular embodiments illustrated in the figures.", "DETAILED DESCRIPTION OF EXEMPLARY EMBODIMENTS According to exemplary embodiments of the present disclosure, methods and apparatus can be provided for producing autografts, and particularly such methods and apparatus which can facilitate more rapid healing of the donor site while providing improved tissue characteristics at the recipient site.", "Exemplary embodiments of the present disclosure can include a plurality of small-scale tissue portions (e.g., micrografts) that can be used to provide autografts.", "Such micrografts can avoid significant permanent damage to the donor site while providing graft tissue that can heal rapidly and generate skin tissue having desirable properties at the recipient site.", "In exemplary embodiments of the present disclosure, a method can be provided for creating autografts in which tissue portions having at least one small dimension (e.g., micrografts) are harvested from an exemplary donor site 100, as shown in FIG.", "1A.", "The holes 110 shown in FIG.", "1A represent regions of the exemplary donor site 100 from which tissue portions (e.g., micrografts) have been removed.", "These exemplary holes 110 can have an approximately round cross-sectional shape, although other shapes may be used.", "The exemplary donor site 100 is shown in FIG.", "1B after healing of the harvested tissue has occurred.", "The small regions of damage 100 created at the donor site by the removed tissue can heal rapidly and/or without visible scarring.", "For example, the residual pattern of the healed donor site 100 shown in FIG.", "1B may not be easily perceptible by the naked eye under normal viewing conditions.", "An exemplary micrograft 120 that can be formed, e.g., by harvesting or removing a portion of the tissue from the donor site 100 to form the hole 110 therein, is shown in FIG.", "1C.", "The exemplary micrograft 120 can have an elongated shape that may be approximately cylindrical.", "The micrografts 120 can include both epidermal tissue 130 and dermal tissue 140 from the exemplary donor site 100.For example, the exemplary micrograft 120 can be about 3 mm in length, which can correspond to a typical total depth of the skin layer (e.g., epidermal and dermal layers).", "A different length may be used based on the particular skin or tissue characteristics of the donor site 100.In general, it can be preferable to avoid harvesting a significant amount of subcutaneous tissue, so the harvested micrografts 200 can include primarily the epidermal tissue 130 and the dermal tissue 140.A lower portion 150 of the exemplary micrograft 120 can also include stem cells that can be present in a lower portion of the dermal layer of the donor site 100 (e.g., near a dermal/fatty layer boundary).", "A width or diameter of the holes 110 produced during harvesting (which can correspond approximately to the diameters of the portions of the harvested micrografts 120) can be less than about 2 mm, or less than about 1 mm.", "In certain exemplary embodiments of the present disclosure, the diameter or width of a micrograft 120 can be less than about 0.5 mm, less than about 0.3 mm.", "or about 0.2 mm.", "The size of the exemplary holes 110 can be selected, e.g., based on the effects of creating small damage regions in the donor site 100 that can heal rapidly and/or without scarring, and on creating portions of tissue that can be small enough to promote viability when transplanted or placed in a growth medium, and large enough to form a sufficient amount of graft tissue and/or capture tissue structures that may be present in the donor tissue.", "For example, living tissue can be provided with nutrients via a diffusional transport over distances of about 0.1 mm.", "Accordingly, the exemplary micrografts 120 having at least one dimension that is less than about 0.5 mm, e.g., less than about 0.3 mm or, e.g., as small as about 0.2 mm, can exhibit improved viability and likelihood to survive, and they may grow when used in a graft.", "Such exemplary micrografts 120 can be better able to receive nutrients (including, e.g., oxygen) when placed in a recipient site, prior to revascularization of the tissue.", "Larger micrografts 120, e.g., those having a width of about 1-2 mm, can also benefit from such diffusional transport of nutrients, and can also be more likely to survive than significantly larger portions of graft tissue (e.g., conventional full-thickness, split-thickness or meshed grafts).", "These larger sizes can be preferable for harvested tissue that is heterogeneous, e.g., tissues that may contain certain structures that can be preserved within a single micrograft 120.For example, skin tissue has certain structures such as hair follicles, sebaceous glands, etc., and harvesting somewhat larger micrografts 120 from skin may help to preserve these tissue structures when harvested and transplanted.", "On the other hand, smaller micrografts, e.g.", "those less than about 0.5 mm, or about 0.2 mm wide, can be suitable for relatively homogeneous tissues, such as muscle tissue, where there are few or no larger structures in the tissue to be preserved.", "A fraction of surface tissue removed from the donor site 100 by harvesting (which can correspond to a fractional surface area of the exemplary donor site 100 occupied by the holes 110) can be less than about 70%, or more preferably less than about 50%.", "The fraction of tissue removed can be sufficiently large to provide enough harvested micrografts 120 to form a graft therefrom of appropriate size, but small enough to facilitate rapid healing at the donor site 100 based on growth from the remaining undamaged tissue.", "Other fractions of tissue can be removed from a donor site 100 depending on factors such as e.g., the particular characteristics of the donor site 100, the size of the graft needed, and the overall amount of donor site tissue available.", "In further exemplary embodiments of the present disclosure, a graft 200 can be provided by embedding or inserting a plurality of micrografts 120 in a biocompatible matrix 210 as shown, e.g., in FIG.", "2A.", "The exemplary matrix 210 containing the micrografts 120 can be exposed to nutrients to promote growth of the harvested micrografts 120, e.g., to form a continuous or nearly continuous layer of tissue in the graft 200 after growth has occurred.", "The exemplary graft 200, which can include the matrix 210 and the micrografts 120, may be placed directly over a recipient site 220 (e.g., a cleaned wound area) as shown in FIG.", "2B.", "The exemplary micrografts 120 can also include stem cells as described herein, which can also facilitate healing and integration of the exemplary micrografts 120 when they are transplanted to the recipient site 220.The recipient site 220 can provide nutrients and/or promote revascularization of the harvested micrografts 120, which can further enhance their growth through the matrix 210 to eventually fill in the spaces separating them.", "For example, FIG.", "2B shows the micrografts 120 after they have begun to grow into the surrounding matrix 210.In one exemplary embodiment of the present disclosure, the micrografts 120 can be placed in the matrix 210 at approximately the same spacing (e.g., a similar areal density) as they were removed from the donor site 100.This exemplary configuration can generate an amount of graft tissue that may be approximately the same size as the overall harvested area of the donor site 100 after the micrografts 120 grow and fill in the spaces between them with new tissue.", "The average spacing of the micrografts 120 in the matrix 210 can also be increased to form a graft tissue that is larger than the overall area of the harvested donor site 100.The particular spacing of the micrografts 120 in a particular graft 200 can be selected based on factors such as, e.g., the size and fractional damage of the donor site 100, the size of the recipient site 220 to be covered by the skin graft 200, the time needed for the micrografts 120 to regrow and form a continuous tissue layer, the desired appearance of the grafted recipient site, etc.", "For example, the exemplary micrografts 120 can be spaced far apart in a particular graft, which can provide a larger graft area but can also require longer healing time and the possibility of some visible scarring or texture in the healed graft 200.In a further exemplary embodiment of the present disclosure, tissue portions 320, such as those shown in FIG.", "3C, can be harvested in an elongated, narrow strip-like shape.", "One or more of the exemplary tissue strips 320 can include both epidermal tissue 130 as well as dermal tissue 140, which can be similar to the micrograft 120 shown in FIG.", "1C.", "For example, the height of the exemplary tissue strip 320 can be about 3 mm, or another length that may correspond to a local depth of the dermal layer at the donor site 100.Larger and/or smaller depths of the dermal layer can also be selected when harvesting tissue strips 320 based on, e.g., characteristics of the donor and recipient sites, the wound to be repaired by grafting, etc.", "Harvesting of such exemplary tissue strips 320 can leave long, narrow grooves 310 in a donor region 100 as shown, e.g., in FIG.", "3A.", "A width of the grooves 310 (and thus a width of the harvested tissue strips 320) can be less than about 1 mm, or less than about 0.5 mm.", "In certain exemplary embodiments, the width of such tissue strips can be less than about 0.3 mm, or about 0.2 mm.", "As described herein, such a small dimension can facilitate diffusional transport of nutrients to the graft tissue and can improve viability of the harvested tissue.", "A depth of the grooves 310 from the skin surface can correspond to the height of the harvested strips 320.A surface area fraction of the exemplary donor site 310 that is removed to form tissue strips 320 can be less than about 70%, or about 50% or less.", "Factors governing a selection of parameters associated with the harvested elongated tissue strips 320 (e.g., widths and area fractions removed from the donor site) may be similar to those described above with respect to the substantially cylindrical micrografts 120.The length of the harvested strips 320 can be selected based on factors such as, for example, ease of cutting, removing, and handling the thin tissue strips 320, the size of the donor site 100, etc.", "The elongated grooves 310 formed in the donor site may also be able to heal rapidly with little or no visible scarring, as shown in FIG.", "3B, because of the small lateral dimension and presence of adjacent healthy tissue that can support local tissue regrowth.", "The harvested strips 320 can be placed, e.g., in a biocompatible matrix similar to the matrix 210 shown in FIG.", "2A.", "The tissue strips 320 can be arranged in an approximately parallel configuration, e.g., corresponding to the configuration of the donor-site grooves 310 from which they were removed.", "The spacing between the strips 320 can alternatively be increased or decreased relative to the spacing of the grooves 310 in the donor site 100 as desired, e.g., to provide either larger overall areas of graft tissue or more densely packed graft tissue, respectively.", "Such harvested tissue strips 320 can be used for certain grafting procedures because the long dimension can preserve structures in the harvested skin tissue that may promote revascularization and improve healing of the graft formed therefrom.", "Harvested tissue portions can be removed from the donor site in other shapes, including tile patterns or fractal-like shapes.", "In general, each removed piece of tissue (and, e.g., each corresponding hole or void in the donor site) can have at least one small dimension that is less than about 1 mm, or less than 0.5 mm.", "In certain exemplary embodiments, this small dimension can be less than about 0.3 mm, or about 0.2 mm.", "In further exemplary embodiments of the present disclosure, the harvested tissue portions can be placed at the recipient site in a dense configuration.", "For example, FIG.", "4A shows a schematic top view of a plurality of substantially cylindrical micrografts 120 that can be gathered in an exemplary dense arrangement, e.g., where adjacent ones of the exemplary micrografts 120 are in at least partially direct contact each other.", "FIG.", "4B is a schematic side view of the micrografts 120 shown in FIG.", "4A.", "This exemplary dense configuration can provide a graft that is smaller than the overall area of the harvested donor site 100, but which can tend to heal faster and be less likely to produce visible scarring than grafts formed using spaced-apart harvested tissue portions 120, 320.Similar exemplary dense configurations of the harvested tissue can be formed using, e.g., elongated strips of tissue 320 shown in FIG.", "3C or the like.", "The exemplary biocompatible matrix 210 can be formed using one or more materials structured to provide mechanical stability and/or support to the harvested micrografts 200, and/or which may promote tissue regrowth.", "Examples of materials which can be used to form the matrix 210 can include polylactic acid (PLA), collagen (e.g., a collagen sponge), low melting agarose (LMA), hyaluronic acid (e.g., hyaluranon), or devitalized animal or cadaveric skin.", "The matrix 210 can, for example, be formed of allogeneic skin that can be prepared, e.g., by freezing and thawing a portion of donor skin tissue several times.", "For example, about seven freezing/thawing cycles can be performed to effectively kill the cells in the donor skin for use as a matrix 210.The frozen and thawed tissue can then be washed with a detergent or other composition to remove dead cells, debris, etc.", "In a further exemplary embodiment of the present disclosure, living donor skin tissue samples can be treated with radiation to form the matrix material 210.For example, donor skin tissue can be treated with lethal doses of x-rays, e.g.", "gamma rays, which can leave the cells intact.", "Cells in the donor matrix material may thus stay alive for a particular duration after radiation exposure, e.g., about 48-72 hours, before dying.", "Such a matrix 210 including short-lived cells can initially support growth of implanted micrografts 120 but then die off before any significant interactions adverse to growth and/or viability of the micrografts 120 can occur such as, e.g., autoimmune responses.", "Alternatively, the implantation of such an irradiated matrix 210 with the viable micrografts 120 can be delayed for a sufficient time after irradiation, e.g., about 72 hours or more, to avoid any autoimmune response between the micrografts 120 and the matrix 210.The matrix 210 can also be prepared from donor skin, for example, by washing the cells away with detergent and acidic/basic solutions.", "An exemplary protocol for preparing such matrices or scaffolds is described, e.g., in Alsberg et al., Proc Natl Acad Sci USA.", "2002 September 17; 99(19): 12025-12030.In a further exemplary embodiment of the present disclosure, small portions of a matrix material as described herein can be combined with the micrografts 120, e.g., in a configuration similar to that shown in FIGS.", "4A and 4B, except that some of the columns are formed of matrix material.", "The micrografts 120 and matrix columns can be adhered using, e.g., adhesives, photochemical bonding, etc.", "The relative sizes and numbers of the micrografts 120 and portions of matrix material can be varied to generate a compound substance that has a particular fraction of micrograft material.", "Nutrients or other additives can also be provided in the matrix 210 to further promote tissue regrowth.", "Such additives can include, e.g., one or more growth factors, stem cells, etc.", "Examples of such growth factors include, but are not limited to, vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-β), and fibroblast, growth factor (FGF), which may enhance or promote vascularization of the grafts.", "Epidermal growth factor (EGF) and keratinocyte growth factors can also be used, and may increase mobilization and differentiation of certain skin cells, such as keratinocytes and fibroblasts.", "Platelet-rich plasma (which can be prepared, e.g., from a patient's own blood, using commercially available systems) can also be used to provide certain growth factors.", "Although such plasma can be more labor-intensive to prepare (from the standpoint of clinical personnel) than exogenous growth factors, it may provide a better approximation of the natural wound-healing environment.", "Such growth factors can be introduced to the matrix 210, e.g.", "a LMA/collagen mix, at a moderate temperature where the matrix is still in a liquid form.", "The LMA/collagen matrix can then be formed by adjusting the pH value of the collagen solution before combining it with heated LMA.", "For a solidification of the matrix 210, for example, the mix can be stored for about 20 min at a temperature of about 37° C. before cooled it down to about 4° C. Stem cell sources can include, e.g., adipose tissue-derived stem cells and/or bone marrow-derived mesenchymal stent cells.", "Micrografts obtained or harvested from skin tissue may also contain stem cells from hair follicles.", "Such stem cells or other cells can be incorporated into the matrix by culturing the cells with the matrix prior to implantation of micrografts.", "Low-level light therapy (LLLT) can also be used to facilitate growth and viability of the micrografts.", "For example, red or near-infrared light can be used to illuminate the donor site and/or the recipient site after tissue harvesting and placement of the graft tissue to further promote healing and/or growth of the tissue.", "Growth factors and/or other additives may be introduced into the matrix, e.g., by soaking the matrix material in a solution containing growth factors prior to implantation of micrografts therein.", "The growth factors can also be introduced by releasing them into the matrix over time using a controlled-release mechanism, e.g., by directing or pumping the growth factors from a reservoir into the matrix over time, or by embedding growth factors in a biodegradable polymer that can be introduced into the matrix.", "Certain growth factors or additives can also be attached to the matrix material by chemical bonds that can be severed over time, thereby releasing the growth factors into the matrix gradually.", "In certain exemplary embodiments of the present disclosure, certain techniques such as photochemical tissue bonding can be used to improve mechanical stability of the micrografts 120 and/or tissue strips 320 in the matrix 210.For example, a technique for a photochemical tissue bonding is described in U.S. Pat.", "No.", "7,073,510.This technique includes an application of a photosensitizer to a tissue, followed by irradiation with electromagnetic energy to produce a tissue seal.", "For example, a photo sensitizer such as Rose Bengal can be applied to the matrix 210 containing the exemplary micrografts 120 and/or tissue strips 320, followed by exposure of the matrix to green light for about two minutes.", "Photochemical tissue bonding can catalyze a polymerization reaction which may facilitate a stronger bonding of the micrografts 120 and/or tissue strips 320 to the matrix 210, where the matrix 210 can include a protein such as, e.g., hyaluronic acid or collagen.", "In further exemplary embodiments of the present disclosure, the matrix material can be provided in a liquid or gel precursor form that can be mixed with the micrografts 120.The matrix material can then be solidified or gelled (e.g., either before or after introducing the mixture of micrografts 120 and matrix material into the recipient site).", "Solidification of the matrix material to form the matrix 210 can be achieved using various procedures based on the matrix material used.", "For example, collagen gels (such as those depicted in FIG.", "16) can be provided in liquid form at lower temperatures, and may be solidified by raising the temperature to about 37° C. Other matrices 210 can be formed using polymers that can be solidified by chemical cross-linking mechanisms.", "Such mechanisms can be activated, catalyzed and/or initiated, e.g., by temperature, light (similar to photochemical tissue bonding), a change in pH, or the like.", "If the micrografts 120 are provided in the matrix 210 that is initially in a liquid form, the orientation of the micrografts 120 within the matrix 210 can be set and/or maintained in several ways.", "For example, a lipid-rich material can be applied to the an upper end or portion of the micrograft 120 (e.g., the epidermal surface of the micrograft 120 obtained from skin tissue), such that the tops of the micrografts 120 would tend to float to the surface of the liquid matrix material, thereby aligning the upper ends of the micrografts 120 towards the upper surface of the matrix 210.Alternatively, a metallic paint can be applied to an upper portion of the micrografts 120, and a magnetic field can then be applied proximal to the graft material to align the micrografts 120 within the matrix material.", "Such exemplary alignment procedures can be performed before and/or during solidification or gelation of the matrix material to produce a matrix 210 that has micrografts 120 therein that have a particular orientation.", "Alternatively, in certain exemplary embodiments of the present disclosure, the micrografts 120 can be provide in the matrix 210 without a particular preferred orientation.", "In still further exemplary embodiments of the present disclosure, an apparatus 500 can be provided, such as that shown in FIG.", "5A, which can facilitate harvesting of the exemplary micrografts 120 from the donor site 100 as described herein.", "The exemplary apparatus 500 can include a hollow tube 510 that can be formed of metal or another structurally rigid material.", "For example, the tube 510 can be formed using a stainless steel tube, a biopsy needle, or a similar structure.", "The tube 510 can be coated with a lubricant or low-friction material, such as Teflon®, to further facilitate the passage of the tubes 510 through the donor site tissue 100.The inner diameter of the tube 510 can be selected or structured to approximately correspond to a particular diameter of a micrograft 120 to be removed from the donor site 100, as described herein.", "According to one exemplary embodiment, the inner diameter of the tube 510 can be less than about 1 mm.", "For example, 18 or 20 gauge biopsy needles (e.g., having an inner diameter of 0.838 mm and 0.564 mm, respectively) or the like can be used to form the tube 510.A biopsy tube having a larger gauge (and smaller inner diameter) can also be used.", "Based on the interaction between the tube width or diameter of the harvested micrograft 120 can be slightly smaller than the inside diameter of the apparatus 500 used to harvest it.", "A distal end of the tube 510 can be shaped to form a plurality of points 520.For example, the two exemplary points or extensions 520 shown in FIG.", "5A can be formed by grinding opposite sides of the tube 510 at an angle relative to the long axis of the tube 510.In a further exemplary embodiment as shown in FIG.", "5B, an exemplary apparatus 550 can be provided that includes the tube 510 with three points or extensions 520 provided at a distal end thereof.", "This exemplary configuration can be formed, e.g., by grinding 3 portions of the tube 510 at an angle relative to the long axis thereof, where the three portions can be spaced apart by about 120 degrees around the perimeter of the tube 510.In still further exemplary embodiments, an apparatus can be provided for harvesting micrografts that includes a tube having more than three points or extensions 520 provided at a distal end thereof, e.g., a tube 510 having four, five, six, seven or eight points 520.The exemplary points or extensions 520 can facilitate insertion of the apparatus 500, 550 into the tissue at the donor site 100.The exemplary points or extensions 520 that can be formed, e.g., by grinding portions of the distal end of the tube 510 can also have a beveled edge along their sides, which can further facilitate insertion of the apparatus 500, 550 into donor-site tissue.", "For example, the points or extensions 520 that form a narrow angle at their tip can be inserted into the tissue using a smaller force as compared to points 520 having a larger tip angle, although this force may be applied for a longer distance and/or time to achieve full insertion of the tube 510 into the tissue than that used for tips that have a wider tip angle and thus shorter length of the angled tip region.", "The initial force needed for the tube 510 to penetrate the tissue can be approximately proportional to the number of points 520 if the angle of each point or extension 520 is held constant.", "Providing a greater number of points extensions 520 at the distal end of the tube can improve mechanical stability of the tube 510 and/or geometrical control of the severed tissue, but it can use a larger force to penetrate the tissue.", "The exemplary apparatus 500 can also included a collar or stop 540 provided on an outer surface of the tube 510.The exemplary stop 540 can be affixed to the tube 510 at a particular distance from the ends of the tips 520, or this distance may be adjustable, e.g., over a range of lengths by moving the stop 540 along the axis of the tube 510.FIG.", "6A illustrates the exemplary apparatus 500 after it is inserted into the tissue at the donor site 100, e.g., until the stop 540 contacts the surface of the donor site 100.A portion of the tissue 600 can be present within a lower portion of the tube 510.Lateral sides of this tissue portion 600 can be cut or severed from the surrounding tissue by the distal end of the tube 510 and/or the points or extensions 520 as the tube 510 penetrates into the donor site tissue 100.Such tissue 600 can remain within the tube 510, and be separated from the donor site 100 to form the micrograft 120, e.g., when the tube 510 is removed from the donor site 100, as shown in FIG.", "6B.", "The exemplary micrograft 120 thus formed can include both epidermal tissue 130 and dermal tissue 140.The exemplary micrograft 120 can be removed from the apparatus 500, e.g., by providing pressure through an opening 620 at a proximal end of the tube 510 as shown, e.g., in FIG.", "6C.", "Such pressure can be mechanical, hydraulic, pneumatic, etc.", "For example, the pressure can be provided, e.g., by blowing into the opening, by squeezing a flexible bulb attached thereto, by opening a valve leading from a source of elevated pressure such as a small pump, etc.", "Alternatively, the exemplary micrografts 120 can be harvested by inserting the exemplary apparatus 500 into a plurality of locations of the donor site 100.Each micrograft 120 within the tube 510 can then push any micrografts above it towards the opening 620.Once the tube 510 has been substantially filled with the harvested tissue, each additional insertion of the exemplary apparatus 500 into the donor site 100 can facilitate pushing of an uppermost micrograft 120 within the tube 510 out of the proximal opening 620.The exemplary apparatus 500 can be inserted into the donor site tissue 100 to a depth corresponding approximately to a desired length of the harvested micrografts 120.Such distance can be determined and/or controlled, e.g., by appropriate placement or adjustment of the stop 540 on the exemplary apparatus 500.For example, the exemplary apparatus 500 can be configured or structured such that the points or extensions 520 extend to a location at or proximal to the dermal/fatty layer junction 610 as shown in FIG.", "6A.", "For example, the micrograft 120 can be removed from the donor site 100 by removing the apparatus 500 from the donor site without rotating the tube 510 around the axis thereof.", "In contrast, conventional biopsy needles and the like may require a rotation around the long axis to facilitate removal of tissue samples from the surrounding tissue.", "The points or extensions 520 provided on the exemplary apparatus 500 can facilitate such removal of the micrograft 120 from the surrounding tissue at the donor site 100.In certain exemplary embodiments of the present disclosure, some or all of the tissue at the donor site may be cooled, frozen, or partially frozen prior to harvesting the micrografts 120.Such freezing may facilitate cutting, removal, handling, and/or viability of the micrografts 120.The donor site tissue 100 may be cooled or frozen using conventional cooling techniques such as, e.g., applying a cryopspray or contacting a surface of the donor site 100 with a cooled object for an appropriate duration.", "The exemplary apparatus 500 can also be cooled prior to harvesting the micrografts 120.Such cooling and/or freezing can, e.g., increase mechanical stability of the micrografts 120 when they are harvested and/or placed in the matrix 210.The exemplary micrografts 120 can be provided into the matrix 210 using various techniques.", "For example, the individual micrografts 120 can be inserted into particular locations of the matrix 210 using, e.g., tweezers or the like.", "The exemplary apparatus 500 containing a harvested micrograft 120, as shown in FIG.", "6B, can also be inserted into a location of the matrix 210, and pressure can be applied to the proximal opening 620 to push the micrograft 120 into the matrix 210.The exemplary apparatus 500 can then be removed from the matrix 210, and the procedure repeated to place a plurality of micrografts 120 in the matrix 210.The proximal opening 620 can be covered while the apparatus 500 is being inserted into the matrix 210 to prevent the micrograft 120 from being pushed further up into the apparatus 500.For example, the upper portion of the tube 510 can be filled with a fluid, e.g., water or a saline solution, to provide an incompressible volume that can further prevent the micrograft 120 from rising further up into the tube 510.Such fluid can also facilitate a removal of the micrograft 120 from the exemplary apparatus 500 by providing pressure at the proximal opening 620.In a further exemplary embodiment of the present disclosure, an exemplary apparatus 700 can be provided, as shown in FIG.", "7.The apparatus 700 can include, e.g., a plurality of the tubes 510 affixed or mechanically coupled to a base 710.The tubes 510 can be provided in various configurations, e.g., in a linear array, or in any one of various two-dimensional patterns along the base 710.The number of the tubes 510 provided in the exemplary apparatus 700 can be, for example, at least 6 tubes 510, more than about 10 tubes 510, or more than about 20 tubes 510.For example, the apparatus 700 can include a linear array of about 3 tubes 510, at least 6 tubes 510, or an array of about 12 tubes 510, e.g., in a rectangular 3×4 array or a 2×6 array.", "Larger arrays of the tubes 510 can also be provided in further exemplary embodiments of the present disclosure.", "The spacing of the tubes 510 can be somewhat irregular or varied to avoid formation of recognizable patterns in the donor and/or recipient sites.", "A larger number of the tubes 510 can be preferable to more rapidly harvest and/or implant a large number of micrografts 120.However, a larger number of the tubes 510 can also correspond to a greater force used to insert the tubes 510 into tissue or a matrix simultaneously, which may be undesirable if the force is too large.", "Also, the mechanical complexity of the apparatus 700 can increase with a larger number of tubes 510.A conduit 720 can be provided in communication with proximal openings 620 of the tubes 510.The conduit 720 can also be provided in communication, e.g., with a pressure source 730.For example, the pressure source 730 can include a pump or a deformable bulb or the like.", "The pressure source 730 can include, e.g., a flexible membrane provided in communication with the conduit 720, such that an elevated pressure can be provided within the conduit 720 when the membrane is deformed.", "Such configurations can facilitate applying pressure to the proximal openings 620 for removal and/or insertion of the micrografts 120 that can be harvested in the tubes 510, as described herein.", "A vibrating arrangement 740 can optionally be provided in the apparatus 700.The vibrating arrangement 740 can be mechanically coupled to the base 710 and/or the tubes 510 to facilitate the insertion of the tubes 510 into the tissue or matrix material for harvesting or placement of micrografts 120.The vibrating arrangement 740 can have an amplitude of vibration in the range of about 50-500 μm, or between about 100-200 μm.", "The frequency of the induced vibrations can be between about 10 Hz and about 10 kHz, or between about 500 Hz and about 2 kHz, or even about 1 kHz.", "Particular vibration parameters can be selected based on, e.g., the size, average spacing, and material of the tubes 510, the number of tubes 510 in the exemplary apparatus 700, and/or the tissue being treated.", "The vibrating arrangement 740 can include circuitry configured to adjust the amplitude and/or frequency of the vibrations.", "The exemplary apparatus 700 can be used to simultaneously obtain a plurality of the micrografts 120 in one or more of the tubes 510.Exemplary procedures for obtaining and removing such micrografts 120 using the exemplary apparatus 700 can be similar to the procedures described herein for obtaining single micrografts 120 using the exemplary apparatus 500 shown in FIGS.", "6A-6C.", "A vibration can also assist in severing tissue proximal to the distal end of the tubes 510 after they are fully inserted into the donor site 100.This can facilitate separation and/or extraction of the tissue portions within the tubes 510 from the donor site 100.These tissue portions can also be held by friction within the tubes 510 as the tubes 510 are withdrawn from the donor site 100.In further exemplary embodiments of the present disclosure, the donor site tissue can be pre-cooled prior to insertion of the tubes 510, e.g., using convective or conductive techniques such as applying a cryospray or contacting the tissue surface with a cooled object.", "Cooling of the donor site 100 can reduce a sensation of pain when the tubes 510 are inserted into the donor site tissue 100, and can also make the tissue 100 more rigid and facilitate a more accurate severing of tissue portions (e.g., micrografts 120) by the tubes 510.The positions and spacing of the tubes 510 in the exemplary apparatus 700 can be determined, e.g., based on characteristics of the micrografts 120 to be obtained, a damage pattern to the donor site 100, and/or other factors as described herein above.", "The number of the tubes 510 provided in the exemplary apparatus 700 can be selected based on various factors.", "For example, a larger number of tubes 510 may be desirable to allow more micrografts 120 to be harvested simultaneously from a donor site 100.Such exemplary configuration can facilitate a more efficient harvesting process.", "A smaller number of the tubes 510 can be easer to insert simultaneously into the donor site tissue 100.Further, the exemplary apparatus 500 having a very large number of the tubes 510 can be challenging to manufacture and/or maintain.", "The harvested tissue portions can be deposited directly from the tubes 510 into the biocompatible matrix material 210.The tubes 510 and the tissue portions contained therein can be cooled before removal of the tissue portions.", "This can stiffen the tissue portions within the tubes 510 and make them easier to manipulate and position.", "In a further exemplary embodiment of the present disclosure, an apparatus can be provided that includes a plurality of substantially parallel blades.", "The ends of certain ones of the adjacent blades can be connected or closed off to provide, e.g., narrow rectangular openings between adjacent blades.", "Such an exemplary apparatus can be used, e.g., to form the tissue strips 320, such as that shown in FIG.", "3C.", "Spacings, lengths, and other features of this exemplary apparatus can be selected based on factors similar to those described herein, e.g., for the exemplary apparati 500, 700.In further exemplary embodiments of the present disclosure, the exemplary methods and apparati described herein can be applied to other tissues besides skin tissue, e.g., internal organs such as a liver or heart, and the like.", "Thus, grafts can be formed for a variety of tissues while producing little damage to a donor site and facilitating rapid healing thereof, while creating graft tissue suitable for placement at recipient sites.", "An image of a distal end of an exemplary apparatus that includes two points is shown in FIG.", "8A.", "This exemplary apparatus is similar to the exemplary apparatus 500 illustrated, e.g., in FIG.", "5A.", "A further rotated image of this exemplary apparatus is shown in FIG.", "8B.", "Such exemplary apparatus was formed using a tube having an outside diameter of about 1 mm, and an inside diameter of about 0.5 mm.", "The points or extensions were formed by grinding two opposite sides of the distal end of the tube at an appropriate angle relative to the axis of the tube.", "The angle used in the exemplary apparatus shown in FIGS.", "8A and 8B was about 30 degrees, although other angles may also be used.", "A beveled edge of the tube wall can be seen along the sides of the points or extensions.", "The shape of these points can facilitate insertion of the apparatus into tissue of a donor site and/or separation of a portion of micrograft tissue from the donor site, as described in more detail herein.", "For example, such micrografts can be separated and removed from the donor site by inserting and withdrawing the apparatus from the donor site tissue without rotating the tube along its axis.", "The geometry of the distal (‘piercing’) end of an exemplary tube 510 that includes two points 520 can be characterized by an angle α, which represents the angle between each of the opposing lateral sides of the tube 510 that form the points or extensions 520 and the longitudinal axis of the tube 510.The angled lateral sides at the distal end of the tube 510 can each be ground or cut at this angle α relative to the axis of the tube 510, e.g., to form a beveled structure at the distal end of the tube 510.The angle formed at the points or extensions 520 when viewed from the side can thereby be represented by the angle 2α, as shown in FIG.", "8C.", "For example, the exemplary tip angle of about 30 degrees shown in FIGS.", "8A and 8B corresponds to an angle α of about 15 degrees.", "A further beveled surface can be optionally provided in a direction orthogonal to the primary bevel that is characterized by the angle α shown in FIG.", "8C.", "This second bevel can be characterized by an angle β, which represents the angle at which each of the opposing lateral sides of the tube 510 can be ground or cut relative to the longitudinal axis of the tube 510, as shown in FIG.", "8D.", "This second bevel can be provided to reduce the size or width of the sharp edge of the tips 520 formed at the end of the tube 510.FIGS.", "8E, 8F and 8G illustrate exemplary beveled ends of the tube 510, where the primary bevel angle α can be about 6 degrees.", "For example, there is no secondary bevel formed in FIG.", "8E, and the points or extensions 520 have a flat cutting edge with a length equal to the thickness of the wall of the tube 510.FIGS.", "8F and 8G include a secondary bevel, where the angle β corresponding to this secondary bevel is also 6 degrees.", "The secondary bevel is relatively shallow in the exemplary tip region shown in FIG.", "8F, which provides a shorter flat cutting edge at the tips of the points or extensions 520.The secondary bevel is deeper in the exemplary tip region shown in FIG.", "8G, such that the tips of the points or extensions 520 form sharp points that can facilitate penetration of tissue more easily.", "FIGS.", "8H, 8I, and 8J illustrate exemplary beveled ends of the tube 510, similar to those shown in FIGS.", "8E-8G, but where the primary bevel angle α is 12 degrees.", "There is no secondary bevel formed in FIG.", "8H, a shallow secondary bevel shown in FIG.", "8I having an angle β of about 6 degrees, and a deep secondary bevel shown in FIG.", "8J, again with an angle β of, e.g., about 6 degrees.", "The various geometries and points 520 described above and shown in FIGS.", "8A-8F can be used in any of the exemplary embodiments of the present disclosure, e.g., for the various devices and methods described herein.", "For example, the hollow tube 510 can be provided with a bevel angle α of less than about 15 degrees, e.g., about 12 degrees.", "Such an acute tip angle can provide sharp tips of the points or extensions 520 that can easily penetrate a biological tissue or matrix material.", "A narrower tip angle α, e.g.", "about 6 degrees as shown in FIGS.", "8E-8G, may be preferable for harvesting and/or implanting micrografts in a denser or tougher tissue or matrix material, where the narrower tips of the points or extensions 520 can be configured to more easily cut through the tissue or matrix material when the tube 510 is inserted therein.", "A secondary bevel having an angle β, such as the exemplary tips of the points or extensions 520 shown in FIGS.", "8F, 8G, 8I, and 8J, can further facilitate insertion of the distal end of the tube 510 into various materials by providing the tips of the points or extensions 520 that are smaller and more pointed.", "However, the tips of the points or extensions 520 that are sharper and/or narrower, e.g., those having small tip angle α and/or a secondary bevel with angle β, can also be more prone to wear, bending, or other deformation if the tube 510 is repeatedly inserted into tissue or a matrix.", "Accordingly, the tip geometry selected for a particular application can be selected based on the type of material or tissue the apparatus will be used with, as well as the desired lifetime of the tube 510.FIG.", "9 shows an exemplary image of a plurality of micrografts obtained from a donor site of ex vivo skin tissue using the exemplary apparatus shown in FIGS.", "8A-8B.", "The micrografts are elongated and substantially similar in shape, although details of the shapes may be somewhat irregular.", "An upper portion of these micrografts includes epidermal tissue, and the lower portion of these micrografts include dermal tissue removed from the donor site.", "The width of these micrografts is slightly smaller than the internal diameter of the tube 510 shown in FIGS.", "8A-8B that was used to harvest them.", "The micrografts shown in FIG.", "9 were removed from the apparatus by inserting the exemplary apparatus into donor site a plurality of times, until the tube was filled with harvested tissue.", "Each subsequent insertion of the apparatus into the donor site tissue then forced the uppermost micrograft out of the proximal end of the tube, where it was retrieved individually for analysis.", "Such micrografts can also be removed by applying pressure to the proximal end of the tube containing the micrograft, to expel it from the distal end of the tube as described herein.", "In still further exemplary embodiments of the present disclosure, an apparatus 1000 can be provided, such as that shown in FIG.", "10A, which can facilitate harvesting of the exemplary micrografts 120 from the donor site 100 and optionally placing them in a biocompatible matrix 210, as described herein below.", "The exemplary apparatus 1000 can include a hollow tube 1010 that can include a plurality of points 1020 at the distal end thereof as described herein, which can be similar to the hollow tube 510 shown in FIGS.", "5A and 5B.", "In one exemplary embodiment of the present disclosure, the tube 1010 can be provided with two points 1020, and the points 1020 can be formed by grinding opposite sides of the distal end of the hollow tube 1010 at an acute angle, e.g., about six degrees, relative to the longitudinal axis of the tube 1010.Such an acute tip angle, e.g., of about 12 degrees or less, can be particularly effective for penetrating and cutting the biological tissue to remove small micrografts 120 therefrom.", "Such a tube provided with two points 1020 can use a force approximately twice that associated with a single-point needle of similar diameter to penetrate tissue or another material.", "For example, FIG.", "19A illustrates an exemplary sequence of inserting and extracting or withdrawing a harvesting needle device from a tissue layer.", "The exemplary needle device can be similar to the hollow pointed tube 510 shown in FIG.", "5A, or the exemplary pointed tube 1010 shown in FIG.", "10A.", "A plot of the position of the needle relative to the tissue as a function of time is shown in FIG.", "19B, together with a plot of the corresponding force applied to the exemplary needle (e.g., along the longitudinal axis) to perform the insertion and extraction sequence.", "The needle used to obtain the data shown in FIG.", "19B was formed from a 25 gauge tube with a tip bevel angle α of 6 degrees and a side bevel angle β of 6 degrees, similar to the exemplary needle geometry shown in FIGS.", "8C, 8D, and 8F.", "As provided in the graph of FIG.", "19B, the needle can be rapidly inserted through the tissue layer at about 6 seconds and held there for about one second, and then steadily withdrawn to a position outside of the tissue layer over a time span of about 0.8 seconds.", "There can be an apparent delay in the force needed to maintain the needle at a certain depth after insertion into the tissue, and a residual force on the needle after it is brought to a position outside of the tissue layer.", "During insertion and extraction of the needle, which was formed using a 25 gauge tube, the maximum and minimum forces observed on the needle were about −0.2 N and 0.2 N, respectively.", "The delay between movement of the needle in and out of the tissue and the resultant force on the needle may result at least in part from deformation of the tissue as the needle is inserted and withdrawn, and/or some adhesion of the tissue to the needle as the needle is moved relative to the tissue.", "The small force appearing at the beginning and end of the sequence plotted in FIG.", "19B are likely associated with some component friction and/or the vertical load cell sensing attached components.", "In one exemplary embodiment of the present disclosure, the tube 1010 can be formed using a 25 gauge thin-wall needle, with an exemplary outer diameter of about 0.51 mm and an internal diameter of about 0.31 mm.", "This exemplary needle size can be used to harvest micrografts 120 having a width or diameter of about 0.2 mm.", "The tube 1010 can be formed of any sufficiently strong material that is preferably biocompatible or inert with respect to biological tissue, e.g., a 304 stainless steel, a surgical stainless steel, etc.", "Further finishing processes can be applied to the tube 1010, such as electropolishing to increase sharpness of the cutting edges or providing a ME-92® chromium coating to increase the material strength.", "Such finishing processes can increase the cutting effectiveness and/or improve the useful service life of the needle 1010.The tube 1010 can be slidably attached to a substrate 1030, such that the tube 1010 passes through a hole provided in the substrate 1030, as shown in FIG.", "10A.", "The position of the tube 1010 relative to the substrate 1030 can be controlled by a positioning arrangement that can controllably translate the tube 1010 relative to the substrate 1030, e.g., substantially along the longitudinal axis of the tube 1010.In this manner, the distance that the distal end of the tube 1010 protrudes past the lower surface of the substrate 1030 can be controllably varied.", "The exemplary apparatus 1000 further includes a pin 1040 provided in the central lumen or opening of the tube 1010.The diameter of the pin 1040 can be substantially the same as the inner diameter of the tube 1010 or slightly smaller, such that the pin 1040 can be translated along the axis of the tube 1010 while filling or occluding most or all of the inner lumen of the tube 1010.The pin 1040 can be formed of a low-friction material, or coated with a low-friction material such as, e.g., Teflon® or the like, to facilitate motion of the pin 1040 within the tube 1010 and/or inhibit accumulation or sticking of biological material to the pin 1040.The distal end of the pin 1040 can be substantially flat to facilitate displacement of a micrograft 120 within the tube 1010 when the pin 1040 is translated.", "In one exemplary embodiment of the present disclosure, the tube 1010 can be formed using a 25 gauge thin-wall needle, with an exemplary outer diameter of about 0.51 mm and an internal diameter of about 0.31 mm.", "This exemplary needle size can be used to harvest micrografts 120 having a width or diameter of about 0.2 mm.", "A pin 1040 that can be used with a tube 1010 of this size can have an outer diameter of about 0.24 mm.", "The difference between the inner diameter of the tube 1010 and the diameter of the pin 1040 can facilitate motion of the pin 1040 within the tube 1010, whereas the pin is sufficiently wide to push a micrograft 120 out from the interior of the tube 1010.The tube 1010 and/or the pin 1040 can be formed of any sufficiently strong material that is preferably biocompatible or inert with respect to biological tissue, e.g., a 304 stainless steel, a surgical stainless steel, etc.", "The pin 1040 can be provided with a further positioning arrangement that can controllably translate the pin 1040 relative to the tube 1010 e.g., substantially along the longitudinal axis of the tube 1010.In this manner, the position of the distal end of the tube 1010 relative to that of the distal end of the pin 1040 can be controllably varied.", "For example, the location of the distal ends of both the tube 1010 and the pin 1040 relative to that of the lower surface of the substrate 1030 can preferably be controllably and independently selected and varied.", "An exemplary illustration of the tube 1010 and pin 1040 as described herein is shown in FIG.", "10B, which shows the pin 1040 positioned relative to the tube 1010 such that their distal ends are substantially aligned.", "Portions of the pin 1040 and/or tube 1010 can optionally be provided with a coating or surface treatment to reduce friction between them and/or between either component and biological tissue.", "Exemplary coatings that can be used include a plastic or polymer, e.g.", "nylon or polyethylene, a polished metal alloy, or the like.", "A schematic side view of an exemplary apparatus 1100 that can be used to facilitate harvesting of the exemplary micrografts 120 from the donor site 100 and optionally placing them in a biocompatible matrix 210 is shown in FIG.", "11.The apparatus 1100 can include the tube 1010, pin 1040, and substrate 1030 shown in FIG.", "10A.", "A plate 1110 or other supporting structure can be affixed to the substrate 1030, or optionally provided with the substrate 1030 as a single unitary component.", "A first actuator 1120 can be affixed to the plate 1110, and mechanically coupled to the tube 1010 using a first coupling arm 1125 or the like.", "Similarly, a second actuator 1130 can be affixed to the plate 1110, and mechanically coupled to the pin 1040 using a second coupling arm 1135 or the like.", "The first actuator 1120 and second actuator 1130 can be conventional linear actuators or the like.", "Such actuators 1120, 1130 can include appropriate controls such that the locations of the coupling arms 1125, 1135 relative to the plate 1110 (and substrate 1130) can be controllably positioned and varied independently.", "For example, the linear range of motion of the actuators 1120, 1130 can be about 2 cm or less for many typical uses of the apparatus 1100, e.g., for harvesting micrografts of skin tissue and placing them in a matrix as described herein below.", "In the exemplary schematic configuration of the apparatus 1100 shown in FIG.", "11, the translation or positioning range of the actuator 1120 can be selected such that the distal end of the tube 1010 can be raised above the lower surface of the substrate 1030, and lowered such that the distal end protrudes to a maximum distance of about 1-2 cm below the lower surface of the substrate 1030.Similarly, the positioning range of the actuator 1130 can be selected such that the distal end of the pin 1040 can be raised above the distal end of the tube 1010 by a distance of about 1-2 cm, and lowered such that the distal end of the pin 1040 is substantially aligned with the distal end of the tube 1010 (e.g., aligned with the tips of the points 1020).", "The translation range of the actuators 1120, 1130 can also be greater than these exemplary distances, for example, if the donor tissue being harvested is relatively thick.", "Alternatively, these translation ranges may be somewhat smaller if micrografts are being harvested from thin layers of tissue and optionally placed in a thin matrix.", "An exemplary sequence for harvesting a micrograft 120 from a donor site 100 and placing it in a matrix 210 in accordance with embodiments of the present disclosure is shown in FIGS.", "12A-12E.", "As an initial matter, the surface of the donor site can be cleaned, sterilized, shaved, and/or otherwise prepared, and a portion or sheet of a matrix material 210 can be placed thereon, as shown in FIG.", "12A.", "The distal ends of the tube 1010 and the pin 1040 can be aligned by the respective actuators (not shown), and positioned proximal to the upper surface of the matrix 210.The tube 1010 and the pin 1040 can be translated such that the distal ends thereof penetrate or pass through the thickness of the matrix 210, and are positioned proximal to the surface of the donor site 100 as shown in FIG.", "12B.", "The tube 1010 and pin 1040 can push aside a small amount of the matrix material, which can be viscous, pliable, elastic, or the like, as they pass through the matrix 210.The tube 1010 can then be translated downward such that it penetrates into the tissue of the donor site 100, while the position of the pin 1040 can be held substantially stationary relative to the donor site 100 such that its distal end remains positioned proximal to the surface of the donor site 100, as shown in FIG.", "12C.", "The distal end of the tube 1010 can sever a portion of the tissue from the surrounding tissue at the donor site as the tube 1010 penetrates the donor site, such that a portion of tissue from the donor site 100 can be located within the distal end of the lumen of the tube 1010.The depth of penetration of the tube 1010 into the donor site 100 can be controlled by the tube actuator 1120, as shown in FIG.", "11.The tube 1010 can be translated such that the distal end thereof is located at a particular depth within the donor site tissue.", "For example, if the donor site is skin tissue, the distal end of the tube 1010 can be extended such that it is proximal to the lower end of the dermis layer, e.g., such that it penetrates slightly into the underlying fatty tissue as shown in FIG.", "12C.", "The tube 101 and pin 1040 can then be lifted or retracted simultaneously such that they substantially maintain their relative positions until the distal end of the tube 1010 is proximal to the surface of the donor site 100 or slightly above it, as shown in FIG.", "12D.", "The portion of tissue severed from the donor site 100 by the tube 1010, which can be used as a micrograft 120, can also be held within the distal end of the tube 1010, such that it is lifted or removed from the donor site 100 as the tube 1010 is withdrawn therefrom.", "If the tissue being harvested is skin tissue, removal of the micrograft 120 from the donor site can be facilitated if the tube 1010 first penetrates to at least an upper surface of the subdermal fatty layer.", "The lower end of the micrograft 120 can be more easily detached or torn away from adjacent fatty tissue than from dermal tissue.", "As shown in FIG.", "12D, s withdrawal of the tube 1010 and the pin 1040 together from the donor site 100 can place the micrograft 120 within the layer of the matrix material 210.For example, the tube 1010 and the pin 1040 can be raised substantially simultaneously such that the distal end of the tube 1010 is positioned proximal to the lower surface of the matrix material 210 or within the matrix material 210.The tube 1010 can then be further retracted from the matrix 210 while holding the location of the pin 1040 substantially stationary relative to the matrix 210, as shown in FIG.", "12E.", "This exemplary procedure facilitates placement of the micrograft 120 substantially within the material of the matrix 210 using the pin 1040 as the tube 1010 is retracted from around the micrograft 120.In this manner, the micrograft 120 can be placed within the matrix 210 and remain there, while the tube 1010 and the pin 1040 are completely removed from the donor site 100 and matrix 210.The exemplary apparatus shown in FIG.", "11 and the tissue harvesting sequence shown in FIGS.", "12A-12D and described herein provide several advantages for harvesting micrografts 120 from the donor site and placing them in the matrix 210 to facilitate their use in grafting or autografting procedures.", "For example, the micrograft 120 can be positioned within the matrix 210 without being exposed to open air (or another intermediate environment) to reduce a chance of contamination, biological stress, etc.", "The various penetration depths can be selected or adjusted based on the desired depth of the micrografts to be harvested, the thickness of the matrix material 210 to be used, etc.", "The micrografts 120, which may be difficult to manipulate because of their small size and/or soft tissue consistency, can be placed in the matrix 210 in substantially the same orientation as they had within the donor site.", "The substrate 1030 shown in FIG.", "11, if present, can provide a mechanical stabilization to the matrix 210 and a surface of the donor site 100 when the apparatus 1100 is placed over the layer of matrix material 210.Placing the substrate 1030 over the matrix 210, if present, and/or the donor site 100 can inhibit motion and/or deformation of the matrix 210 and tissue of the donor site 100 while the micrografts 120 are being harvested.", "In a further exemplary embodiment of the present disclosure, the substrate 1310 can include a plurality of strips or slats 1315, as shown in FIG.", "13B, with elongated openings between them.", "The black dots shown in FIG.", "13B are micrografts that were harvested from a donor site that was colored black, and implanted into the recipient site shown in this figure.", "Both the donor and recipient sites were skin tissue of a pig, creating an allograft.", "The substrate 1030 can be placed over the donor tissue 100 as described above to stabilize the tissue 100, while the harvesting tubes 510, 1010 can be inserted into the tissue 100 between the slats 1315.The substrate 1310 can also be used to facilitate positioning of the tubes 510, 1010 relative to the donor tissue, e.g., for repeated insertions and extractions of the tube 510, 1010 from a region of donor tissue 100.The substrate 1030 can also be provided with other geometrical shapes and arrangements of openings therethrough, such as a plurality of openings having an elliptical, triangular, square, or other shape, or a combination thereof.", "In a further exemplary embodiment of the present, disclosure, the substrate 1030 can be placed directly on the surface of the donor site 100 to provide mechanical stabilization and reduce movement of the tissue of the donor site 100, as shown in FIG.", "13.The substrate 1030 can be provided with one or more holes 1310 therethrough.", "One or more of the tubes 1010 can be configured to pass through the holes 1310 to sever and extract micrografts 120 from the donor site, e.g., as described above and illustrated in FIGS.", "12A-12E.", "The matrix 210 can be provided on top of the substrate 1030 as shown in FIG.", "13A.", "Optionally, a layer of dressing material 1320 or the like can be placed on the top surface of the matrix 210 to further stabilize the matrix 210 and/or facilitate handling of the matrix 210.If the substrate 1030 is provided between the matrix 210 and the donor site, as shown in FIG.", "13A, the translation distances or heights of the tube 1010 and pin 1030 shown in the sequence of FIGS.", "12A-E can be controlled appropriately such that the micrografts 120 are harvested from the donor site 100 and deposited in the matrix 210 above the substrate 1030.In a further exemplary embodiment of the present disclosure, two substrates 1400, 1410 can be used to provide further stabilization, as shown in FIG.", "14.A lower substrate 1410 having one or more holes 1420 therethrough can be provided on the surface of the donor site 100, similar to the substrate 1030 shown in FIG.", "13A.", "The matrix 210 can be provided on top of the lower substrate 141., An upper substrate 1400 can be provided on top of the matrix 210 or dressing material 1320, if present.", "Such upper substrate 1400 can be provided with one or more holes 1425 therethrough, which can correspond to and/or be aligned with the holes 1420 provided in the lower substrate 1410.These aligned holes 1420, 1425 can facilitate translation of the tube 1010 into and out of the matrix 210 and donor site tissue 100 while providing mechanical stability to both the donor site 100 and the matrix 210.Such aligned holes 1420, 1425 in the lower substrate 1410 and upper substrate 1400 can also provide a further mechanical stability and an improved alignment of one or more of the tubes 1010 as they are translated vertically through the holes 1420, 1425.In a still further exemplary embodiment of the present disclosure, a barrier 1430, e.g.", "a sidewall or the like, can be provided between the lower substrate 1410 and the upper substrate 1400 as shown in FIG.", "14, e.g., proximal to the perimeter of one or both substrates.", "The lower substrate 1410, the upper substrate 1400, and the barrier 1430 can together form an enclosure around the matrix 210.This exemplary configuration can facilitate containment of the matrix 210, e.g., if the matrix 210 is formed from a viscous or easily deformable material.", "Accordingly, the exemplary embodiment of the present disclosure shown in FIG.", "14 can facilitate a placement of micrografts 120 into the matrix 210 that may likely not be mechanically rigid or stable.", "The exemplary embodiment shown in FIG.", "14 may be used with other various embodiments of the present disclosure described herein.", "The exemplary apparatus 1100 can be used to harvest a plurality of micrografts 120 from the donor site 100, and optionally place them in the matrix 210.For example, the substrate 1030 can be provided with a plurality of spaced-apart holes therethrough.", "The plate 1110 shown in FIG.", "11, or another portion of the apparatus 1100 supporting the tube 1010 and pin 1040, can be configured or structured to be translatable over the substrate 1030, such that the tube 1010 and pin 1040 can be positioned over a plurality of holes in the substrate 1030.Such translation can be in one dimension (e.g., linear) or in two dimensions, e.g., over a particular surface region of the substrate 1030.In this exemplary manner, a plurality of micrografts 120 can be harvested from a donor site 100 and placed in a plurality of locations in the matrix 210, e.g., proximal to a plurality of the holes in the substrate 1030, while maintaining the substrate 1030 and the exemplary apparatus 1100 in a single location relative to the donor site 100.In a further exemplary embodiment of the present disclosure, the apparatus 1100 shown in FIG.", "11 can be provided with a plurality of the tubes 1010 and of the pins 1040.All of the tubes 1010 can be translatable together using a single first actuator 1120, or certain ones of the tubes 1010 can be translated simultaneously and/or sequentially using a plurality of the first actuators 1120 and appropriate first coupling arms 1125.Similarly, the plurality of pins 1040 can be translatable together using a single second actuator 1130, or certain ones of the pins 1040 can be translated simultaneously and/or sequentially using a plurality of second actuators 1130 and appropriate second coupling arms 1135.In general, it may be preferable for the translation of each of the tubes 1010 to be coordinated with its associated pin 1040 (i.e., the pin 1040 provided in the lumen of the particular tube 1010).", "In this exemplary manner, each combination of the tube 1010 and the associated pin 1040 can be controlled to perform the exemplary harvesting and implanting sequence illustrated in FIGS.", "12A-12E.", "The matrix 210 containing one or more micrografts 120 as described herein can be used as a graft material that can be placed over a recipient site of damaged tissue that has been suitably prepared.", "In general, this graft material will include a plurality of micrografts 120 that are provided in the matrix 210.The spacing of the micrografts 120 in the matrix 210 can be selected to facilitate the micrografts to grow within or through the matrix 120 and eventually provide sufficient coverage and/or repair of the damaged region.", "The micrografts 120 can be placed in the matrix 210 in a uniform pattern, randomly, or in any other desired spatial arrangement.", "In certain exemplary embodiments of the present disclosure, the density or spacing of the implanted micrografts 120 can vary in different regions of the matrix 210.For example, a higher density and/or smaller spacing of the micrografts 120 can be provided closer to the edges of the matrix 210 to improve peripheral integration and/or revascularization of the graft.", "A sterile dressing or the like can be placed over the graft material after it is placed on the damaged region of tissue.", "Such dressing can be adhered to the graft material to facilitate handling and positioning of the graft material on the recipient site.", "In a further exemplary embodiment of the present disclosure, the harvested micrografts 120 can be introduced or transplanted directly into, e.g., substantially whole tissue at the recipient site.", "For example, the micrografts 120 can be harvested from the donor site 100 that may contain melanocytes, and inserted directly into tissue at a recipient site that lacks sufficient melanocytes.", "Such exemplary procedure can be used to repigment skin tissue, e.g., to treat vitiligo or similar conditions.", "Tissue at the recipient site 100 can also be frozen or partially frozen, as described herein, prior to insertion of micrografts 120 therein.", "An exemplary apparatus 1500 for implanting micrografts 120 into a recipient site 1510 is shown in FIGS.", "15A-15E.", "The apparatus 1500 can include the hollow tube 1010 that can include a plurality of the points 1020 at the distal end thereof, and the pin 1040 provided in the central lumen or opening of the tube 1010, similar to the apparatus shown in FIG.", "10A.", "The exemplary apparatus 1500 can further include a hollow piercing needle 1520 that can be provided around the tube 1010, as shown in FIG.", "15, such that the tube 1010 can be advanced and/or retracted within the piercing needle 1520.The piercing needle 1520 can include a single point 1525 configured to pierce and penetrate a biological tissue.", "The piercing needle 1520 can be manually controlled, or it can be controlled using an actuator, e.g., similar to the actuators 1120, 1130 in the exemplary apparatus 1100 shown in FIG.", "11.In an exemplary method of the present disclosure, the tube 1010 and the pin 1040 can be used to harvest a tissue micrograft 120, for example, using the exemplary harvesting sequence shown in FIGS.", "12A-D.", "The micrograft 120 can be retained in the tube 1010 when the tube 1010 and pin 1040 are fully withdrawn from the donor site 100.The tube 1010 and the pin 1040 can be located within the piercing tube 1520 such that the distal end of the tube 1010 is within the piercing needle 1520, as shown in FIG.", "15A.", "The piercing needle 1520 can then be advanced into the recipient site 1510, such that the point 1525 of the piercing needle 1520 separates a portion of the tissue in the recipient site 1510 as shown in FIG.", "15B.", "The tube 1010 and pin 1040, together with the micrograft 120, can be advanced forward together with the piercing needle 1520 such that the distal end of the tube 1010 containing the micrograft 120 is located below or proximal to the surface of the recipient site 1510, as shown in FIG.", "15B.", "The piercing needle 1520 can be withdrawn from the recipient site 1510 while holding the tube 1010 substantially stationary relative to the recipient site 1510, such that the distal end of the tube 1010 containing the micrograft 120 is located within the separated tissue of the recipient site 1510, as shown in FIG.", "15C.", "The tube 1010 can then be withdrawn from the recipient site 1510 while holding the pin 1040 substantially stationary relative to the recipient site 1510, such that the micrograft 120 remains within the separated tissue of the recipient site 1510 when the tube 1010 is withdrawn, as shown in FIG.", "15D.", "Upon removal of the apparatus 1500 from the recipient site 1510, the micrograft 120 can remain within the recipient site 1510 in a known orientation, as shown in FIG.", "15E.", "Such direct implantation can be used for tissue normalization, e.g., to treat vitiligo by transplanting the micrografts 120 containing melanin directly into a depigmented recipient site 220.The exemplary micrografts 120 can also be harvested from a healthy donor site 100 and placed directly into the recipient site 1510 that includes scar tissue to facilitate growth of healthy tissue in the scar using the exemplary method and apparatus shown in FIGS.", "15A-5E.", "In a further exemplary embodiment of the present disclosure, portions of tissue can be removed from the recipient site 1510 prior to placing micrografts 120 in holes that are formed at the recipient site 1510 by the removal of these tissue portions.", "The holes can be about the same size or slightly larger than the size of the micrografts 120 to be inserted therein, to facilitate such insertion.", "The holes can be formed at the recipient site, e.g., using one or more of the tubes 510 as described herein, by removing or ablating the tissue using, e.g., an ablative laser, etc.", "The exemplary method and apparatus illustrated in FIGS.", "15A-15D can be used for a variety of procedures, including grafting between or among various tissues besides skin, such as, e.g., muscle tissue, organ tissue, etc.", "“Hybrid” or heterogeneous grafts involving different tissues can also be generated using the exemplary methods and apparatus described herein.", "For example, the micrografts 120 from the donor site having a first tissue type can be placed in a second type of tissue at a donor site.", "Such exemplary grafting procedures can be used in many different applications.", "For example, micrografts 120 from an endocrine organ can be placed in a donor site 1510 that includes skin.", "For example, pancreatic tissue micrografts can be placed in skin tissue to provide for insulin secretion.", "As another example, smooth muscle tissue can be introduced into the gastrointestinal tract.", "Micrografts 120 obtained from other functional tissues may be placed in donor sites having different characteristics.", "In certain exemplary embodiments of the present disclosure, the piercing needle 1520 can be provided around at least a portion of the tube 510, 1010 without a sharpened point 1525.The distal end of the piercing needle 1520 can be flat, for example, and the outside of the distal end may optionally be widened or flanged.", "Such a piercing needle 1520 can serve as a guide and/or support for the tube 510, 1010, and can reduce or prevent bending, distortion, breakage, etc.", "of the tube 510, 1010 when it is inserted into and withdrawn from a donor tissue site.", "It can also facilitate control of the insertion depth of the tube 1010 and/or the pin 1040 (if present) in the tissue.", "In further exemplary embodiments of the present disclosure, a conduit can be provided in communication with the lumen of the tubes 510, 1010 described herein, e.g., connected to a proximal end of the tubes 510, 1010.Such conduit can be configured similar to the conduit 720 shown in FIG.", "7.The conduit can also be provided in communication with a source of low and/or high pressure, e.g., a vacuum arrangement and/or a source of pressurized gas or liquid.", "For example, the diameter of the pin 1040 can be sized slightly smaller than the internal lumen diameter of the tube 1010.Such a configuration can facilitate a fluid such as a gas to pass through the lumen of the tube 1010 around the pin 1040, and further allow pressure differentials to propagate through the lumen of the tube 1010.A controlled application of low pressure from the conduit to the lumen of the tube 1010 can facilitate a separation of the micrografts 120 from surrounding tissue.", "Similarly, an application of an elevated pressure from the conduit into the lumen of the tube 1010 can facilitate removal or expulsion of a micrograft 120 from the tube 1010 after it is harvested.", "In a further exemplary embodiment of the present disclosure, a fluid can be provided within the tube 510 shown in FIGS.", "5A and 5B or the tube 1010 shown in FIG.", "10A, e.g., such that a portion of the fluid is present between the tube 1010 and the pin 1040.This fluid can reduce friction between the pin 1040 and the tube 1010.The fluid can also reduce or prevent a buildup or accumulation of biological tissue proximal to the distal end of the tube 1010 when the tube 1010 is used to harvest a plurality of tissue micrografts 120.The fluid can also facilitate a retention of the micrografts 120 in the tube 1010 and/or release of the micrografts 110 from the tube, e.g., by providing the fluid at a reduced or elevated pressure during appropriate steps in the exemplary micrograft manipulation sequences shown, e.g., in FIGS.", "6A-6C, 12A-12E, and/or 15A-15D.", "For example, the fluid can improve the accuracy of placement of the micrografts 120 in tissue 1510 at the donor site or in the matrix 210 as described herein.", "Such accuracy in positioning the harvested micrografts 120 can, e.g., reduce or prevent a formation of cysts or other undesirable results when the micrografts 120 are allowed to grow after harvesting.", "Such fluid can be provided, e.g., through a conduit or the like that can be provided in communication with a proximal end of the tube 1010, similar to the conduit 720 shown in FIG.", "7.Alternatively, the fluid can be provided through an opening formed in the side of the tube 1010, etc.", "If the piercing needle 1520 is used, such as provided in the exemplary apparatus 1500 shown in FIG.", "15, the fluid can also or alternatively be provided between the piercing needle 1520 and the tube 1010.Exemplary fluids that can be used can be biocompatible, inert with respect to the biological tissue, etc.", "Such fluid preferably would not produce any adverse effect when contacting the tissue 100, 1510.For example, the fluid may include a saline solution, glycerol, or the like.", "It may be buffered, and can include one or more additional components, such as anticoagulants, antibacterial agents, coagulants, etc.", "One or more growth factors can also be added to this fluid to expose the micrografts 120 to such growth factors before implanting them in the matrix 210 or directly into the recipient site 220, which can enhance the viability of the micrografts 120.Force sensors, optical sensors, and/or position sensors can optionally be provided in communication with the actuators 1120, 1130 and/or the tubes 510, 1010 and/or pin 1040, to improve control of the exemplary harvesting and/or matrix implantation procedures described herein.", "For example, such sensor can be used to detect penetration depths and/or penetration resistance of the tube 101 and/or the pin 1040 to assist in harvesting and/or implanting particular layers of tissue and/or sizes of the micrografts 120.A sensor for detecting the presence of micrografts within the tube 510, 1010 can also be provided.", "Such sensor can include, e.g., a source of a small electric current provided to the tube 510, 1010 that is configured to detect an electrical resistance or change in resistance within the tube 510, 1010.For example, a detected resistance when a small current is flowed to the needle 510, 1010 (e.g., in an electrode configuration) can indicate whether the needle 510, 1010 is empty or if a micrograft 120 is present therein.", "Alternatively, a laser fiber and a photodetector may be provided within the needle to optically detect changes in scattered light, indicating whether or not the micrograft 120 is present.", "Such micrograft sensor could be used, for example, to determine the number or percentage of actual micrografts harvested and/or implanted by the tube 510, 1010, e.g., if a plurality of such micrografts is processed in a two-dimensional scan or traversal of the donor site 100 and/or the recipient site 1510.A relatively small number of “missed” micrografts may be acceptable in a certain procedure, whereas a larger number or percentage of “missed” micrografts can indicate, e.g., that the needle 510, 1010 needs to be replaced, that the graft material is not viable or acceptable, and/or that the procedure should be repeated or continued.", "If detected “missed” micrografts are localized in the donor site 100, this could indicate that the tissue might be structurally different in a particular region, e.g., a mole or small scar can be present in the donor site 100.An exemplary set of images of the micrograft that was collected from pig skin and placed in a collagen gel is shown in FIG.", "16.The epidermal portion of the micrograft is the darker area at the lower end of the micrograft in these images.", "Even at times as short as 12 hours (second image from the left in FIG.", "16), live cells can be observed migrating from the micrograft into the surrounding gel matrix, as indicated by the lighter areas around the dark micrograft.", "This migration is observed to continue 72 hours after placing the micrograft into the collagen gel (rightmost image in FIG.", "16), indicating that the micrografts that are harvested and placed in a matrix, in accordance with exemplary embodiments of the disclosure described herein, can be viable for extended times and can provide viable graft material.", "In further exemplary embodiments of the disclosure, micrografts 120 can be implanted into cleaned wound area 220 without the matrix.", "For example, FIG.", "17 shows a series of exemplary images showing healing of a wound generated in a nude (hairless) mouse, where micrografts obtained from the skin of a black mouse were implanted in the wound area and the wound was then allowed to heal.", "After about 6 weeks, the wound appears to be well-healed, and some tufts of black hair are observable.", "The appearance of these tufts of black hair on the nude recipient site suggest that at least some of the micrografts survived during the healing process and that functional hair follicles were successfully transplanted to the nude recipient.", "FIG.", "18A shows an exemplary wound formed in a swine subject by surgically removing a substantially square region of full-thickness skin tissue (epidermis and dermis, down to the subcutaneous fat layer).", "The size of this wound is approximately 1.5 cm×1.5 cm.", "Micrografts were harvested from a donor site of the swine subject using a device similar to the apparatus 500 shown in FIG.", "5A, in accordance with the exemplary embodiments described herein.", "The micrografts were implanted directly into one such wound (without using a matrix).", "A second similar wound was also generated in the subject and allowed to heal without implantation of any micrografts.", "The upper row of FIG.", "18B illustrates a series of exemplary images showing the healing progress over 4 weeks for the wound shown in FIG.", "18A that had micrografts implanted therein.", "The lower row of FIG.", "18B are exemplary images showing the healing progress over 4 weeks for the wound that had no micrografts.", "The amount of observed wound contraction appears substantially reduced in the wound that had micrografts implanted in the wound site.", "In contrast, the wound without micrografts appears to have contracted more significantly during the healing process.", "Contraction of skin tissue as a wound heals is generally undesirable.", "For example, contraction of the skin around a joint can reduce the range of motion of the joint and may also be painful when the joint is flexed or extended.", "In severe cases, the joint may be rendered substantially or completely immobile (e.g., severe tissue contraction around the temporomandibular joints may prevent opening of a subject's mouth, and may require a liquid diet).", "Accordingly, the implantation of micrografts into a wound area as described herein may reduce tissue contraction during wound healing and thereby reduce or avoid detrimental side effects of such contraction.", "The exemplary methods and apparatus described herein can also be used to harvest other types of biological tissue using the exemplary methods and apparatus described herein, and need not be limited to skin.", "Embodiments of the present disclosure can facilitate harvesting of small tissue portions (e.g.", "micrografts 120) from various organs or tissue types while reducing or avoiding generation of damage in the donor site.", "The harvested tissue portions can provide viable tissue that may be used in various grafting or cultivation procedures.", "The foregoing merely illustrates the principles of the present disclosure.", "Various modifications and alterations to the described embodiments will be apparent to those skilled in the art in view of the teachings herein.", "Various exemplary embodiments described herein can be used with one another interchangeably.", "It will thus be appreciated that those skilled in the art will be able to devise numerous techniques which, although not explicitly described herein, embody the principles of the present disclosure and are thus within the spirit and scope of the present disclosure.", "All patents and publications cited herein are incorporated herein by reference in their entireties." ] ]
Patent_15872551
[ [ "PROACTIVE DEEP-ANALYSIS VIRTUAL ASSISTANT APPLICATION AND INTEGRATION", "A virtual assistant AI system that may be connected to a wide variety of user accounts such as financial accounts, social media, news, shopping, utilities and service providers, travel accounts, and other account types.", "The AI then continually monitors connected accounts for changes, analyzes changes when they occur and identifies any relationships or interactions between accounts and potential or actual implications of changes, and generates proactive notifications and provides them to the user who may then further investigate using virtual assistant AI clients." ], [ "1.A system for providing real-time multidevice messages to a user, comprising: a first computing device comprising a memory, a processor, an audio input component, an audio output component, a wireless network interface, and a plurality of programming instructions operating in the memory and on the processor, the programming instructions configured to: receive a verbal query from a user via the audio input device; transmit the verbal query via a wireless network using the wireless network interface to a virtual assistant platform; receive a query response message from the virtual assistant platform and provide the query response message to the user using the audio output device; receiving a verbal instruction from the user to provide information visually; and transmitting the verbal instruction to the virtual assistant platform; and a second computing device comprising a memory, a processor, a display, an input means, a network interface, and a plurality of programming instructions operating in the memory and on the processor, the programming instructions configured to: receive a data message from the virtual assistant platform via a network, the data message based at least in part on the verbal instruction from the user; displaying graphically at least a portion of data from the received data message on the display; receiving a user interaction event pertaining to the displayed data based on use of the input means; and transmitting a message to the virtual assistant platform via the network based on the user interaction event.", "2.The system of claim 1, wherein the virtual assistant platform comprises a plurality of software APIs, wherein at least a portion of query response comprises information retrieved from a plurality of external data sources via the plurality of APIs.", "3.The system of claim 2, wherein at least a portion of the information retrieved from a plurality of external data sources comprises at least financial information.", "4.The system of claim 3, wherein the financial information comprises historical investment data.", "5.The system of claim 2, wherein at least a portion of the information retrieved from a plurality of external data sources comprises at least user behavior data.", "6.The system of claim 5, wherein the query response comprises a recommendation based at least in part on at least a portion of the user behavior data.", "7.A method for providing real-time multidevice messages to a user, comprising the steps of: receiving, at a first computing device comprising a memory, a processor, an audio input component, an audio output component, a wireless network interface, and a plurality of programming instructions operating in the memory and on the processor, a verbal query from a user via the audio input device; transmitting the verbal query via a wireless network using the wireless network interface to a virtual assistant platform; receiving a query response message from the virtual assistant platform and provide the query response message to the user using the audio output device; receiving a verbal instruction from the user to provide information visually; transmitting the verbal instruction to the virtual assistant platform; receiving, at a second computing device comprising a memory, a processor, a display, an input means, a network interface, and a plurality of programming instructions operating in the memory and on the processor, a data message from the virtual assistant platform via a network, the data message based at least in part on the verbal instruction from the user; displaying graphically at least a portion of data from the received data message on the display; receiving a user interaction event pertaining to the displayed data based on use of the input means; and transmitting a message to the virtual assistant platform via the network based on the user interaction event." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>Accordingly, the inventor has conceived and reduced to practice, in a preferred embodiment of the invention, a virtual assistant platform with deep analytics and proactive interaction.", "The invention comprises a virtual assistant AI system that may be connected to a wide variety of user accounts such as financial accounts, social media, news, shopping, utilities and service providers, travel accounts, and other account types.", "The AI then continually monitors connected accounts for changes, analyzes changes when they occur and identifies any relationships or interactions between accounts and potential or actual implications of changes, such as if a news article mentions events affecting a company in a user's investment portfolio.", "The AI then generates proactive notifications and provides them to the user, such as notification alerts, reminders, suggestions, or prompts for action such as notifying a user of the news event that may impact their investment, and asking if they wish to take action on that company's stock.", "According to a preferred embodiment of the invention, a system for providing real-time multidevice messages to a user, comprising: a first computing device comprising a memory, a processor, an audio input component, an audio output component, a wireless network interface, and a plurality of programming instructions operating in the memory and on the processor, the programming instructions configured to: receive a verbal query from a user via the audio input device; transmit the verbal query via a wireless network using the wireless network interface to a virtual assistant platform; receive a query response message from the virtual assistant platform and provide the query response message to the user using the audio output device; receiving a verbal instruction from the user to provide information visually; and transmitting the verbal instruction to the virtual assistant platform; and a second computing device comprising a memory, a processor, a display, an input means, a network interface, and a plurality of programming instructions operating in the memory and on the processor, the programming instructions configured to: receive a data message from the virtual assistant platform via a network, the data message based at least in part on the verbal instruction from the user; displaying graphically at least a portion of data from the received data message on the display; receiving a user interaction event pertaining to the displayed data based on use of the input means; and transmitting a message to the virtual assistant platform via the network based on the user interaction event, is disclosed.", "According to another preferred embodiment of the invention, a method for providing real-time multidevice messages to a user, comprising the steps of: receiving, at a first computing device comprising a memory, a processor, an audio input component, an audio output component, a wireless network interface, and a plurality of programming instructions operating in the memory and on the processor, a verbal query from a user via the audio input device; transmit the verbal query via a wireless network using the wireless network interface to a virtual assistant platform; receive a query response message from the virtual assistant platform and provide the query response message to the user using the audio output device; receiving a verbal instruction from the user to provide information visually; transmitting the verbal instruction to the virtual assistant platform; receiving, at a second computing device comprising a memory, a processor, a display, an input means, a network interface, and a plurality of programming instructions operating in the memory and on the processor, a data message from the virtual assistant platform via a network, the data message based at least in part on the verbal instruction from the user; displaying graphically at least a portion of data from the received data message on the display; receiving a user interaction event pertaining to the displayed data based on use of the input means; and transmitting a message to the virtual assistant platform via the network based on the user interaction event, is disclosed." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "15/335,407 titled “PROACTIVE DEEP-ANALYSIS VIRTUAL ASSISTANT APPLICATION AND INTEGRATION”, filed on Oct. 26, 2016, which claims the benefit of, and priority to, U.S. provisional patent application Ser.", "No.", "62/349,060, titled, “PROACTIVE DEEP-ANALYSIS VIRTUAL ASSISTANT APPLICATION AND INTEGRATION”, which was filed on Jun.", "12, 2016, and is also a continuation-in-part of U.S. patent application Ser.", "No.", "15/206,231, titled, “VIRTUAL ASSISTANT PLATFORM WITH DEEP ANALYTICS, EMBEDDED AND ADAPTIVE BEST PRACTICES EXPERTISE, AND PROACTIVE INTERACTION”, which was filed on Jul.", "9, 2016, which claims the benefit of, and priority to, U.S. provisional patent application Ser.", "No.", "62/348,946, titled, “VIRTUAL ASSISTANT PLATFORM WITH DEEP ANALYTICS AND PROACTIVE INTERACTION”, which was filed on Jun.", "12, 2016, the entire specification of each of which is incorporated herein by reference in their entirety.", "BACKGROUND OF THE INVENTION Field of the Art The disclosure relates to the field of artificial intelligence, and more particularly to the field of virtual personal assistants.", "Discussion of the State of the Art Virtual assistants are a growing field of artificial technology and continue to offer new ways for users to interact and make requests, but such technologies tend to focus on reactive interaction wherein users ask questions or make requests, and the virtual assistant responds to that immediate demand before returning to an idle state.", "A large benefit to having a personal assistant (virtual or otherwise) is the ability to delegate minor tasks and responsibilities like monitoring calendar tasks, relevant news, travel arrangements, or financial information, yet virtual assistants rely on user requests to provide information and therefore do an imperfect job of relieving the user of the additional effort of monitoring and checking this information.", "What is needed, is a new form of virtual assistant that monitors user accounts and information and proactively identifies relationships and interactions between accounts, and that then proactively interacts with the user so that the virtual assistant can fully handle the monitoring and analysis of a user's personal information and notify the user only when their attention is needed.", "SUMMARY OF THE INVENTION Accordingly, the inventor has conceived and reduced to practice, in a preferred embodiment of the invention, a virtual assistant platform with deep analytics and proactive interaction.", "The invention comprises a virtual assistant AI system that may be connected to a wide variety of user accounts such as financial accounts, social media, news, shopping, utilities and service providers, travel accounts, and other account types.", "The AI then continually monitors connected accounts for changes, analyzes changes when they occur and identifies any relationships or interactions between accounts and potential or actual implications of changes, such as if a news article mentions events affecting a company in a user's investment portfolio.", "The AI then generates proactive notifications and provides them to the user, such as notification alerts, reminders, suggestions, or prompts for action such as notifying a user of the news event that may impact their investment, and asking if they wish to take action on that company's stock.", "According to a preferred embodiment of the invention, a system for providing real-time multidevice messages to a user, comprising: a first computing device comprising a memory, a processor, an audio input component, an audio output component, a wireless network interface, and a plurality of programming instructions operating in the memory and on the processor, the programming instructions configured to: receive a verbal query from a user via the audio input device; transmit the verbal query via a wireless network using the wireless network interface to a virtual assistant platform; receive a query response message from the virtual assistant platform and provide the query response message to the user using the audio output device; receiving a verbal instruction from the user to provide information visually; and transmitting the verbal instruction to the virtual assistant platform; and a second computing device comprising a memory, a processor, a display, an input means, a network interface, and a plurality of programming instructions operating in the memory and on the processor, the programming instructions configured to: receive a data message from the virtual assistant platform via a network, the data message based at least in part on the verbal instruction from the user; displaying graphically at least a portion of data from the received data message on the display; receiving a user interaction event pertaining to the displayed data based on use of the input means; and transmitting a message to the virtual assistant platform via the network based on the user interaction event, is disclosed.", "According to another preferred embodiment of the invention, a method for providing real-time multidevice messages to a user, comprising the steps of: receiving, at a first computing device comprising a memory, a processor, an audio input component, an audio output component, a wireless network interface, and a plurality of programming instructions operating in the memory and on the processor, a verbal query from a user via the audio input device; transmit the verbal query via a wireless network using the wireless network interface to a virtual assistant platform; receive a query response message from the virtual assistant platform and provide the query response message to the user using the audio output device; receiving a verbal instruction from the user to provide information visually; transmitting the verbal instruction to the virtual assistant platform; receiving, at a second computing device comprising a memory, a processor, a display, an input means, a network interface, and a plurality of programming instructions operating in the memory and on the processor, a data message from the virtual assistant platform via a network, the data message based at least in part on the verbal instruction from the user; displaying graphically at least a portion of data from the received data message on the display; receiving a user interaction event pertaining to the displayed data based on use of the input means; and transmitting a message to the virtual assistant platform via the network based on the user interaction event, is disclosed.", "BRIEF DESCRIPTION OF THE DRAWING FIGURES The accompanying drawings illustrate several embodiments of the invention and, together with the description, serve to explain the principles of the invention according to the embodiments.", "It will be appreciated by one skilled in the art that the particular embodiments illustrated in the drawings are merely exemplary, and are not to be considered as limiting of the scope of the invention or the claims herein in any way.", "FIG.", "1 is a block diagram illustrating an exemplary system architecture for a virtual assistant platform with deep analytics and proactive interaction, according to a preferred embodiment of the invention.", "FIG.", "2 is a flow diagram illustrating an exemplary overview method for operating a virtual assistant platform with deep analytics and proactive interaction, according to a preferred embodiment of the invention.", "FIG.", "3 is a flow diagram illustrating an exemplary method for operating a virtual assistant with deep analytics and proactive interaction, illustrating an exemplary use case of deep analytics insights to generate personalized notifications for a user.", "FIG.", "4 is a block diagram illustrating an exemplary hardware architecture of a computing device used in an embodiment of the invention.", "FIG.", "5 is a block diagram illustrating an exemplary logical architecture for a client device, according to an embodiment of the invention.", "FIG.", "6 is a block diagram showing an exemplary architectural arrangement of clients, servers, and external services, according to an embodiment of the invention.", "FIG.", "7 is another block diagram illustrating an exemplary hardware architecture of a computing device used in various embodiments of the invention.", "FIG.", "8 is a flow diagram illustrating the use of a virtual assistant with deep analytics and proactive interaction for predicting and managing the impact of a global event, illustrating processing of an oil refinery accident and its impact on markets and users.", "FIG.", "9 is a flow diagram illustrating the use of a virtual assistant with deep analytics and proactive interaction for assisting a user with a financial trade, illustrating the use of historical analysis and proactive notification to provide the user with a recommendation.", "FIG.", "10 is a flow diagram illustrating the use of a “batting average” algorithm to assist users with financial decisions.", "FIG.", "11 is a process diagram showing how user notifications are generated from events regarding assets, according to an embodiment of the invention.", "FIG.", "12 is a data flow diagram showing various data sources and objects in relation to users, according to an embodiment of the invention.", "FIG.", "13 is a process and data flow diagram showing sequential flow of data and actions leading to user notification, according to an embodiment of the invention.", "FIG.", "14 is a diagram illustrating an exemplary process flow diagram showing how partial status vectors lead to user notifications, according to an embodiment of the invention.", "FIG.", "15 is a table showing a typical status vector, according to an embodiment of the invention.", "FIG.", "16 is a diagram showing communication flow from status vectors to user messages, according to an embodiment of the invention.", "FIG.", "17 is a method diagram for computing batting averages and triggering rules by trading activity of a user, according to an embodiment of the invention.", "FIG.", "18 shows a hierarchical data arrangement, according to an embodiment of the invention.", "FIG.", "19 is an exemplary decision tree, according to an embodiment of the invention.", "FIG.", "20 is an exemplary decision tree, according to an embodiment of the invention.", "FIG.", "21 an exemplary decision tree, according to an embodiment of the invention.", "FIG.", "22 is a conceptual diagram showing different asset classes and goals, according to an embodiment of the invention.", "FIG.", "23 is an illustration of an exemplary user interface for a virtual assistant application, illustrating an exemplary proactive notification display and a user portfolio management interface, according to a preferred embodiment of the invention.", "FIG.", "24 is a block diagram of an exemplary system architecture, illustrating the integration of a virtual assistant with deep analytics and proactive interaction with third-party virtual assistant products to extend their functionality.", "FIG.", "25 is a diagram of an exemplary system architecture, illustrating the use of a mixed audio and visual interaction system for financial information retrieval according to a preferred embodiment of the invention.", "FIG.", "26 is a flow diagram illustrating exemplary function of the mixed audio and visual interaction method available for financial information retrieval according to a preferred embodiment of the invention.", "FIG.", "27 is a flow diagram illustrating an exemplary method for providing real-time multidevice messages to a user, according to a preferred embodiment of the invention.", "DETAILED DESCRIPTION The inventor has conceived, and reduced to practice, in a preferred embodiment of the invention, a virtual assistant platform with deep analytics and proactive interaction.", "One or more different inventions may be described in the present application.", "Further, for one or more of the inventions described herein, numerous alternative embodiments may be described; it should be appreciated that these are presented for illustrative purposes only and are not limiting of the inventions contained herein or the claims presented herein in any way.", "One or more of the inventions may be widely applicable to numerous embodiments, as may be readily apparent from the disclosure.", "In general, embodiments are described in sufficient detail to enable those skilled in the art to practice one or more of the inventions, and it should be appreciated that other embodiments may be utilized and that structural, logical, software, electrical and other changes may be made without departing from the scope of the particular inventions.", "Accordingly, one skilled in the art will recognize that one or more of the inventions may be practiced with various modifications and alterations.", "Particular features of one or more of the inventions described herein may be described with reference to one or more particular embodiments or figures that form a part of the present disclosure, and in which are shown, by way of illustration, specific embodiments of one or more of the inventions.", "It should be appreciated, however, that such features are not limited to usage in the one or more particular embodiments or figures with reference to which they are described.", "The present disclosure is neither a literal description of all embodiments of one or more of the inventions nor a listing of features of one or more of the inventions that must be present in all embodiments.", "Headings of sections provided in this patent application and the title of this patent application are for convenience only, and are not to be taken as limiting the disclosure in any way.", "Devices that are in communication with each other need not be in continuous communication with each other, unless expressly specified otherwise.", "In addition, devices that are in communication with each other may communicate directly or indirectly through one or more communication means or intermediaries, logical or physical.", "A description of an embodiment with several components in communication with each other does not imply that all such components are required.", "To the contrary, a variety of optional components may be described to illustrate a wide variety of possible embodiments of one or more of the inventions and in order to more fully illustrate one or more aspects of the inventions.", "Similarly, although process steps, method steps, algorithms or the like may be described in a sequential order, such processes, methods and algorithms may generally be configured to work in alternate orders, unless specifically stated to the contrary.", "In other words, any sequence or order of steps that may be described in this patent application does not, in and of itself, indicate a requirement that the steps be performed in that order.", "The steps of described processes may be performed in any order practical.", "Further, some steps may be performed simultaneously despite being described or implied as occurring non-simultaneously (e.g., because one step is described after the other step).", "Moreover, the illustration of a process by its depiction in a drawing does not imply that the illustrated process is exclusive of other variations and modifications thereto, does not imply that the illustrated process or any of its steps are necessary to one or more of the invention(s), and does not imply that the illustrated process is preferred.", "Also, steps are generally described once per embodiment, but this does not mean they must occur once, or that they may only occur once each time a process, method, or algorithm is carried out or executed.", "Some steps may be omitted in some embodiments or some occurrences, or some steps may be executed more than once in a given embodiment or occurrence.", "When a single device or article is described herein, it will be readily apparent that more than one device or article may be used in place of a single device or article.", "Similarly, where more than one device or article is described herein, it will be readily apparent that a single device or article may be used in place of the more than one device or article.", "The functionality or the features of a device may be alternatively embodied by one or more other devices that are not explicitly described as having such functionality or features.", "Thus, other embodiments of one or more of the inventions need not include the device itself.", "Techniques and mechanisms described or referenced herein will sometimes be described in singular form for clarity.", "However, it should be appreciated that particular embodiments may include multiple iterations of a technique or multiple instantiations of a mechanism unless noted otherwise.", "Process descriptions or blocks in figures should be understood as representing modules, segments, or portions of code which include one or more executable instructions for implementing specific logical functions or steps in the process.", "Alternate implementations are included within the scope of embodiments of the present invention in which, for example, functions may be executed out of order from that shown or discussed, including substantially concurrently or in reverse order, depending on the functionality involved, as would be understood by those having ordinary skill in the art.", "Conceptual Architecture FIG.", "1 is a block diagram illustrating an exemplary system architecture 100 for a virtual assistant platform 110 with deep analytics and proactive interaction, according to a preferred embodiment of the invention.", "According to the embodiment, virtual assistant platform 110 may connect via the Internet 120 or other data communication network, to interact with a computing device 140 (for example, a user's smartphone or computer) and a plurality of data sources 130 that may comprise a wide variety of information sources such as user financial accounts 131 (such as investment portfolios or bank accounts), social media profiles 132, accounts with service providers 133 such as public utilities or cloud services, news or other media sources 134, and other various sources of available information, whether public or private (with corresponding configuration for access).", "Data from sources 130 may be exposed using a plurality of application programming interfaces (APIs) 111 configured to facilitate communication between data sources 130 and a data collector 112 that receives raw data from connected data sources 130 and stores the data in a raw data storage database 113.This raw data may then be processed by an analysis engine 114 to produce entities for internal use such as to maintain a hierarchical structure as described below, as well as to identify any information changes such as new data or modifications to previously-received data (for example, when a stock price changes, or new posts are uploaded to a social media account, or new travel arrangements are made).", "Processed data may then be placed in a processed information storage database 115, which may optionally be a separate database structure or physical storage from a raw storage 113, or may simply be a logical separation within the same storage schema.", "An intelligent advisor 117 may then retrieve processed data from storage 115 and load configured rules from a rules database 116 (such as rules governing a user's preferences for notifications, thresholds for determining whether a change is significant, timing for updates, or other such configuration information), and may analyze the data to identify relationships between data points (such as identifying that a user has family nearby a newly-booked travel destination, or that they have invested in a company that was mentioned in a recent news article) and to determine (optionally based on a plurality of configured rules) whether any particular change will impact related data entities and whether a user should be notified.", "For example, if a news article mentions a company in which the user holds stock, but it is only a passing reference, the user may not be notified as the implications of this observation are negligible.", "However, if a news article discusses a potential merger between companies, or a change in a product timeline, a user may be notified as this news may impact their stock.", "Notification prompts may then be provided to a messaging server 118 that may operate a plurality of messaging interfaces to accommodate a wide range of user preferences such as to communicate via email, SMS, SKYPE™, push notifications to a user's smartphone or other mobile device, or other such communication methods.", "Notifications may then be produced and transmitted via network 120 to a user's client device 140 for review.", "According to the embodiment, notifications produced based on data insights and provided to a user may vary in nature, for example they may include simple push notification alerts to inform the user of an event, or they may be more complex or interactive such as a prompt for action or a proactive request being made of the user.", "For example, if it is determined that the user has family near a new travel destination, they may be prompted to schedule a lunch with their relatives based on known calendar and travel data.", "Additionally, by combining information from their family members (if available, according to a particular arrangement or configuration), it may be possible to automatically select an ideal time to schedule a meeting that will not conflict with the calendars of any involved parties.", "Another exemplary notification type may be a proactive suggestion provided to the user, such as when a news article mentions a potential product shift from a company in which the user holds stock.", "The user may be presented with a suggestion regarding their stock holdings, based on the inferred relationship between the user's financial profile and the news article, and optionally incorporating historical data such as past stock performance for this company or the user's past investment behavior.", "In this manner, it can be appreciated that the virtual assistant platform 110 provides a variety of proactive functionality to users that is not possible with current technologies, offering personalized suggestions and “reaching out” to a user when necessary without requiring a user to track their own accounts and manually take action.", "According to the embodiment, a variety of algorithm-based approaches and data organizational schema may be used to process and analyze data from sources.", "For example, an internal storage of a user's information and accounts may be modeled as a hierarchical structure of “titles”, each title referring to a configured account, profile, or other significant piece of user information that may be monitored for changes and interactions with other titles.", "Each title communicates with its relevant and defined data sources (such as associated bank accounts, stock tickers, or other information source associated with a configured user account) as to create “status vectors” representing the flow of information from a data source to a title and ultimately to a user.", "Communication may occur according to defined parameters such as an operating mode or interval, for example to update information (checking for any changes, analyzing any new information, etc.)", "every 15 minutes.", "When a change is identified within any title, the status vector may be delivered to the title entity and used to notify the user.", "Index entities may be used internally to refer to discrete portions of information within titles, such as a particular stock's last closing price or a user's social media feed.", "Every title and index entity may be assigned its own status vector, and status vectors may be aggregated from all significant data pushed to these internal entities by all related APIs.", "A user entity may be internally used to represent a human user, and to organize and manage all of the user's data (this may be thought of as a container into which the title hierarchy is placed to associate everything with a user and keep user information separate from other users' information).", "The status vector of a user entity is created from all evaluated titles, and this entity may have a data space comprising historical data used to prepare reports and statistics, and a plurality of entity properties that may be used as drivers for evaluation (such as, for example, “type of investor” or “strength of social network presence”) and that may comprise all communication details for the user.", "DETAILED DESCRIPTION OF EXEMPLARY EMBODIMENTS FIG.", "27 is a flow diagram illustrating an exemplary method 2700 for providing real-time multidevice messages to a user, according to a preferred embodiment of the invention.", "In an initial step 2701, a first computing device comprising a memory, a processor, an audio input component, an audio output component, a wireless network interface, and a plurality of programming instructions operating in the memory and on the processor, may receive a verbal query from a user via the audio input component.", "In a next step 2702 the first computing device may transmit, using the wireless network interface, the verbal query to a virtual assistant platform via a network.", "In a next step 2703, the first computing device may receive a query response from the virtual assistant platform and present it to the user via the audio output component.", "In a next step 2704, the first computing device may then receive a verbal instruction from the user to present the information of the query response visually (rather than via audio), and in a next step 2705 the first computing device may transmit this verbal instruction to the virtual assistant platform.", "In a next step 2706, a second computing device comprising a memory, a processor, a display, an input means, a network interface, and a plurality of programming instructions operating in the memory and on the processor may receive a data message from the virtual assistant platform via the network interface.", "In a next step 2707, the second computing device may present at least a portion of the data message graphically, using the display.", "In a next step 2708, the second computing device may receive a user interaction event from the user via the input means (for example, a keyboard, mouse, or touchscreen interface), and in a final step 2709 may transmit a message back to the virtual assistant platform based at least in part on the user interaction event.", "FIG.", "2 is a flow diagram illustrating an exemplary overview method 200 for operating a virtual assistant platform with deep analytics and proactive interaction, according to a preferred embodiment of the invention.", "According to the embodiment, a data collector 112 may collect a variety of data from external sources in a data mining operation 201.Mined data may then be provided to an analysis engine 114 to be analyzed for personal relevance 202 such as connections between user accounts (for example, if new information from a social media posting refers to a company the user has invested in), social relevance 203 such as connections with external social information (for example, public news or social media postings) or with other users (such as a user's friends, colleagues, or family), and for situational awareness 204 such as known current events or historical trends.", "Observed data correlations may be used to generate recommendations 205 based on data relationships, and may be handled by analysis engine 114 in real-time 206 so that recommendations are produced while they are most relevant—that is, immediately upon discovering changes in data or interactions between relevant data, and with real-time situational awareness providing information context.", "Real-time notifications 207 may then be produced for presentation to the user, such as suggested actions to take in response to observed or predicated changes, alerts based on changes to a user's relevant data (such as fluctuations in stock prices, or life events in social network postings for relevant users such as family), or other notification types.", "FIG.", "3 is a flow diagram illustrating an exemplary method 300 for operating a virtual assistant platform with deep analytics and proactive interaction, illustrating an exemplary use case of deep analytics insights to generate personalized notifications for a user.", "According to the embodiment, data collection 301 may receive a variety of information inputs from different sources such as a social media posting 301a where a user uploaded a photograph of a newborn baby, a credit card transaction showing the user purchasing diapers 301b, and an email conversation discussing parenting 301c.", "This information may then be processed using deep analytics 302 by an analysis engine 114 to find additional relevant data such as a scheduled OBGYN appointment 302a, and to reveal data correlations 302b and create a data “scenario” that connects the information to form a larger view of the events occurring behind these discrete data points.", "This scenario may then be used to cross-examine with other information, for example checking a user's finances 303a to check the state of their savings or investments, or to see whether they have any financial preparation plans established.", "Another example may be to check a user's housing situation 303b, to see how their current living arrangements compare against metrics like crime rates or quality of nearby education for their new child.", "This additional information may then be used to produce specific recommendations and provide them for review by the user, such as prompting the user to review their budgeting goals 304a to revise them for new expenses involved with having a new child or to begin a 529 plan or other preparatory plan to save for future expenses, or to recommend housing changes such as suggesting alternative housing 304b that fits the user's current or proposed budget (for example, after considering savings for child expenses) that may be near better schools, have a number of daycares nearby, or have low crime rates.", "FIG.", "8 is a flow diagram illustrating the use of a virtual assistant with deep analytics and proactive interaction for predicting and managing the impact of a global event, illustrating processing of an oil refinery accident and its impact on markets and users.", "In an initial step 801, a news outlet may report on an event such as an oil refinery accident or other event with potentially far-reaching effects.", "In a next step 802, analysis engine 114 may analyze available information for situational awareness 204, for example to check for related news events (such as a conflict in the region of the oil refinery), financial information (such as companies involved with this oil refinery and events relating to them such as recent or upcoming mergers), or other relevant information title entities (as described previously, referring to FIG.", "1).", "This situational awareness may then be used to perform a variety of analysis examinations of available data to determine who or what may be affected by this event 801, and to determine how to respond.", "Analysis engine 114 may check to determine whether any events are predicted to have a causal relationship with the initial event 803, for example analyzing potential contributing factors or events that may be triggered such as increased local unemployment while the refinery is repaired or abandoned, and may notify users 803a that would be affected by these predicted events or that may already be affected by related contributing events without realizing it.", "Analysis engine 114 may then examine financial markets to determine what changes have occurred or are predicted to occur resulting from this event 804, such as changes in the value of crude oil or in the stock value of the company that owns the oil refinery.", "Users affected by these market changes may be notified 804a and optionally provided with suggested actions to take, such as to sell stock in one company and buy in another to take advantage of the market reaction to the event.", "Analysis engine 114 may then check to see if other companies may be affected by the event 805 such as partners or competitors of the company owning the oil refinery, and may notify users involved with those companies to proactively bring their attention to the potential changes due to this event and optionally offer suggested actions to take.", "For example, a user may own stock in a nearby transportation company that has a contract to transport crude oil into the refinery, that may decrease in value now that the refinery is not operating.", "The user may then be prompted to sell this stock before the market reflects this change, to minimize their losses due to the event.", "When all situational processing is complete, users that may be interested in this event may be notified 806, such as users who have specified a preference for following news pertaining to the local region where the oil refinery is located, or who are interested in news related to energy or resources.", "For example, a user may not be affected by an event but may still wish to follow it for various reasons, and they may be notified of the event based on their preference for being kept informed despite the fact that they are unaffected.", "Another user may potentially be affected, but has not made their information available for analysis (this may be referred to as a “lurker”), instead choosing to stay informed of news events so they can manually decide how to respond.", "FIG.", "9 is a flow diagram illustrating the use of a virtual assistant with deep analytics and proactive interaction for assisting a user with a financial trade, illustrating the use of historical analysis and proactive notification to provide the user with a recommendation.", "In an initial step 901, a user enters a trade they wish to perform.", "The data for this trade is then recorded as data lots 902 to be stored for future reference, such as the specific stocks or commodities being traded, amounts, values, and other trade-related information.", "Analysis engine 114 may then identify patterns in trade data 903 such as trends in market value or user behavioral tendencies, such as if a user tends to invest in similar types of commodity or tends to sell in response to certain types of events.", "These patterns may then be analyzed 904 to determine various probability statistics, such as to extrapolate the likelihood that a user will take a particular action under specific circumstances, or the probabilities for various trade outcomes based on known patterns and historical data.", "A notification may then be generated for presentation to the user 905, based on past trades and other historical data and analysis insights such as patterns and probabilities related to the trade.", "This notification may then be provided to the user 906 with a plurality of proactive suggestions to help the user improve their trade, by incorporating analysis insights based on historical performance and predictions based on patterns and probabilities to improve the outcome of the user's trade.", "The user may then choose to modify their trade in light of the suggestions received, or simply to submit as-is 907, at which point the trade data and results are recorded for future reference 908 and use in further analysis for future trades.", "FIG.", "10 is a flow diagram illustrating the use of a “batting average” algorithm to assist users with financial decisions.", "According to the embodiment, a user's performance (described as “batting average” and “slugging %”) may be calculated based on a variety of information that may be collected and calculated to accurately represent a user's trading performance.", "In an initial step 1001, analysis engine 114 may find the corresponding “buy” and “sell” trades for a user.", "This may take into account a variety of possible situations, such as: the user bought one package and sold that same whole package; the user bought one package and sold it divided into parts; the user bought one package, then another package, and sold the packages together, or the user bought one package and sold a portion of it, then bought another package and sold the combined new package and remaining portion of the first package.", "In a next step 1002, analysis engine 114 may download data about SPY index at the date of trade, and may then calculate the percent of change for the index, for example as (SPY at the clay of selling−SPY at the day of buying)/SPY at the day of buying).", "Next, price and principal data may be retrieved 1003 for use in calculations.", "In a next step 1004, analysis engine 114 may calculate original investment (cost of buying), looking at the operation of corresponding buying for this package.", "For example: Cbi=Qi*Pb For trade on 7.24.2013: Cb1=4000 (Quantity)*0.5(Price of buying)=2000 This corresponds to the cost of buying for asset (original investment; how much did the user pay when they bought a package); below is an exemplary calculation for the cost of selling for asset 1005.Information may be retrieved from the web about SPY index: it is necessary to find out the % of change for SPY index between date of buying trade and selling trade.", "The Cost of Selling: Csi=Qi*PSi=Principali For trade on 7.24.2013: Cs1=4000 (Quantity)*0.8 (Price of selling)=3200 (!", "That's Principal) Cost of selling may be calculated 1005 and corresponds to the amount that a user is selling, multiplied by price of selling.", "It should be equal to Principal, so it is possible to just take the meaning of Principal.", "Dollar Value of a Trade: Vi=Principali−Cbi For trade on 7.24.2013: V1=3200−2000=1200 Next the overall “value” of a trade may be calculated 1006.Dollar value corresponds to the difference between how much the user gains from a trade and how much they paid for the trade.", "Next, the absolute, relative, and average return values may be calculated 1007, for example using calculation algorithms below.", "The absolute return for Qi (each trade of selling): AR i ′ = Principal i - Cb i Cb i AR   1 = 1200 / 2000 = 0 , 6 Efficiency of each trade (percent): Ei=ARi*100% E1=60% Relative return (comparing to S&P 500, SPY in this case): RRi=Ei−SPYi RR1=60%−0.339387%=59.66061% Average Absolute Return: AR _ TQ = ∑ i = 1 n  AR i n Optional auxiliary computations may include: If RRi>=0 then: Fi=1 (the “flag”) and Nw=Nw+1 Nw—number of “winning” trades.", "Otherwise (RRi<0): Fi=0 and NL=NL+1 NL—number of “loosing” trades.", "For example: For the trade on 7.24.2013: RR>0=>F1=1.Nw+1.N1+0 (that's the “winning” trade) These statistics may then be used to compute the batting average 1008 for a user, to indicate their trading performance for use in forming predications and recommendations for current and future trades.", "Batting Average: BA = N w N L For all trades where Fi=1 (that indicates a “winning trade”): V _ M = ∑ j = 1 Nw  V j N w This summarizes the amount of money (dollar value of a trade) for all the winning trades and divide it by the number of winning trades.", "For all trades where Fi=0 (that indicates a “losing trade”):: V _ L = ∑ j = 1 Nl  V j N l Slugging Percentage: SP = V _ w V _ l FIG.", "11 is a process diagram 1100 showing how user notifications are generated from events regarding assets, according to an embodiment of the invention.", "According to the embodiment, portions status vectors 1105 are sent as partial status vectors 1106 to an asset entity 1110, which may be for example a software module configured to receive messages comprising partial status vectors 1106 and to apply rules in handling those messages.", "Asset entity 1110 may comprise a plurality of scenarios, such as scenario 1 1111, scenario 2 1112, and scenario 3 1113, as well as historical data 1114 pertaining to an underlying asset represented by asset entity 1110 (e.g., a stock/equity asset or a bond asset).", "As partial status vectors 1106 arrive at asset entity 1110, they are evaluated against one or more scenarios 1111-1113, possibly using historical data 1114 as well, and when appropriate scenario-generated messages may be sent (e.g., message 1 1115, message 2 1116, message 3 1117, and the like).", "These messages may in turn be sent directly to a user 1101, and may also be sent to one or more portfolio entities 1120.Like asset entity 1110, portfolio entity 1120 may comprise one or more scenarios 1121, 1122 and historical data 1123.Portfolio entity 1120, on receiving messages 1115-1117, evaluates the messages according to one or more scenarios 1121, 1122 and potentially generates messages 1125, 1126, which are sent to user 1101.In this way, as events occur regarding various assets, the corresponding asset status vectors 1105 may be modified, and portions of these vectors may be sent (as partial status vectors 1106) to asset entities 1110 for processing, thereby potentially generating asset-level and portfolio-level messages that are sent to user 1101 as a result of the underlying asset events.", "FIG.", "12 is a data flow diagram 1200 showing various data sources and objects in relation to users, according to an embodiment of the invention.", "According to the embodiment, software APIs may be used to connect to data sources such as bond markets 1215, commodities markets 1216, or Bloomberg 1217 or similar financial data or media sources, and may connect specific asset types such as the Dow Jones 1213 or other financial news or publishing firm, the DAX 1212 or other stock market index, or a variety of commodities such as (for example) agricultural commodities 1211 such as wheat or tobacco, or raw materials 1210 such as metals or oil.", "An API for a particular data source may be configured to receive information from the data source in its native format (that is, as it is naturally stored and provided by that source) and provide any necessary translations or transformations to accommodate the information and integrate it with other data and systems, such as data from other APIs so that information may be stored, tracked, and viewed in a consistent manner.", "Within a plurality of data sources and asset types, there may be a number of specific assets relevant to a user 1240 such as a user's equities 1220-1222, commodities 1225-1227, and bonds 1230-1232.Additional information may be collected from other data sources 1250 such as financial indices and news sources, optionally with or without the use of a specific API as needed (for example, news article information may be publicly available and presented in plaintext, facilitating ease of collection and integration without the use of specially-written software).", "FIG.", "13 is a process and data flow diagram 1300 showing sequential flow of data and actions leading to user notification, according to an embodiment of the invention.", "According to the embodiment, a plurality of data sources 1310 such as (for example) YAHOO™ 1311, Standard & Poor's Financial Services 1312, or RSS feed data 1313 may be collected via a variety of communication adapters 1315 such as APIs for data sources 1316-1318, or an RSS evaluator 1319 that may be used to selectively identify relevant information and process it for use (for example, stripping irrelevant content and identifying associated data.", "Collected data may also comprise an asset hierarchy 1320 describing an organized structure for storing and processing asset-related information, for example an asset type (such as stocks) may be near the “head” of a hierarchical structure, with specific sources (such as specific traded corporations on the stock index) underneath, each branching out into specific assets (specific stocks for the corporations).", "Collected data may then be evaluated 1325, incorporated asset evaluation 1326 for a specific user portfolio 1335 by collecting and evaluating the user's owned assets 1336-1338 and parameters for their assets 1340-1342 such as quantity, date acquired, and other information values that may be associated with a particular asset.", "Portfolio evaluation 1327 may consider a user's portfolio 1335 as well as known information from data sources and an asset hierarchy 1320, and an evaluation of potential 1328 may identify various potential values relevant to the portfolio (such as identifying trends or likely events that may affect a user's portfolio, or that they may wish to act upon preemptively).", "Evaluation results may then be sent to a user application 1329 for review.", "User definitions 1330 may be any number of information values associated with the user, such as demographic information and other user-specific or identifying information.", "FIG.", "14 is a diagram illustrating an exemplary process flow diagram 1400 showing how partial status vectors lead to user notifications, according to an embodiment of the invention.", "According to the embodiment, a partial status vector 1410 may comprise a number of specific status values such as volume, average daily variance, or real-time change.", "These values may be analyzed 1440 to determine appropriate actions to take, such as checking whether volume is greater than a configured threshold for daily variance 1411 and returning true 1415 or false 1416, or whether it is true 1417-1419 that the real-time daily change is greater than 1412, less than 1413, or equal to 1414 the overall change of an index (indicating how this particular asset is performing relative to the market overall).", "Analysis may then drive user notifications, for example if a volume returns “true” 1415 when checked against the average daily variance, then a notification rule may trigger as “true” 1425, notifying a user 1430 accordingly.", "However, if the same analysis returns “false” 1416, a different notification rule 1426 may trigger, and additionally any notification rule may check against data sources such as RSS feeds 1420, for example to verify whether a change is being discussed or presented as positive or negative.", "FIG.", "15 is a table showing a typical status vector 1500, according to an embodiment of the invention.", "According to the embodiment, a status vector 1500 may comprise any number of data types 1501 and values 1502 for an asset, such as (for example) the last price the asset traded at, the last price the asset was trading at when the market closed, the current daily or yearly high and low price values, daily trade volume, current beta (indicating volatility relative to the market as a whole), dividend yield, the status timestamp of the last update, or direct market access values.", "FIG.", "16 is a diagram showing communication flow from status vectors 1610 to user messages 1625-1627, according to an embodiment of the invention.", "According to the embodiment, a plurality of status vectors 1610 comprising portfolio data 1611-1612 may be analyzed for information on asset entities within those portfolios 1620 and processed according to a plurality of scenarios 1621-1623, generating messages 1625-1627 based on the outcome of analysis (as described previously in greater detail, referring to FIG.", "11 and FIG.", "14, above).", "FIG.", "17 is a method diagram for computing batting averages and triggering rules by trading activity of a user, according to an embodiment of the invention.", "In an initial step 1701 of method 1700, a plurality of purchase prices for a user's previous trades are determined.", "In a next step 1702, the corresponding sales prices may be determined for these trades.", "In a next step 1703, the relevant market index price may be determined for each transaction time for these historical trades.", "In next steps 1704-1705, the absolute and relative return values may be determined for trades, and in a next step 1706, determined values may be utilized to compute a user's batting average and slugging percentage across these historical trades.", "In a next step 1707, the tax efficiency of trades may be computed, and in a next step 1708, any fees for trades may be computed.", "In a next step 1709, the price efficiency may be determined, and in a final step 1710 any rules triggered by these trades may be determined.", "FIG.", "18 shows a hierarchical data arrangement 1800, according to an embodiment of the invention.", "According to the embodiment, a market proxy 1801 may be utilized to act as a representative for another market entity, for example if a commodity is not represented on an index but a company who produces the commodity is.", "A daily performance value 1802 may comprise a macro statistics 1803 value, which in turn comprises a plurality of information values organized into a hierarchical structure as illustrated.", "A security selection 1803 pertains to information on a given security, such as (for example, including but not limited to) the type 1804 of security, any known or identified trends 1805, or news events 1808 pertaining to the security.", "Trends may be identified from a research process 1806 and fundamental market research 1807.Asset allocation 1809 may comprise a model-driven asset allocation 1811 process that utilizes a structured asset hierarchy to analyze asset information, and variance to the proxy 1810 (if one is used) to determine how an asset if performing.", "Information may be stored on trades 1812 and trade timing or holding periods 1813, and data collected on hedges 1814 comprising related trade data 1816 and whether it is an alpha- or pair-trade 1815.Additionally, market influence data 1817 may be collected, including upside and downside capture ratios 1818.FIG.", "19 is an exemplary decision tree 1900, according to an embodiment of the invention.", "According to the embodiment, the daily return for a proxy 1901 may be checked to determine whether it is currently on-target 1903, or if it is over 1902 or under-performing 1904.If it is not on-target, the historical data may be checked 1905 to determine how long it has been over or under-performing (under-performing only shown for simplicity and clarity), and this information may be used to determine if the performance is indicative of a trend 1906.Then, the disparity in performance may be analyzed 1907 to determine the cause, by examining the proxy information hierarchy (as described above, referring to FIG.", "18) to identify influencing factors in performance.", "Security selection 1908 may be checked for security type 1913 and research 1918, asset allocation 1909 may be checked for asset type 1914 and any possible drags on asset performance 1919, trading performance 1910 may be checked for timing or holding periods 1915 and alpha information 1920, market influence 1911 may be checked for upside or downside capture information 1916 (and if downside, then it can be determined that any performance is not due to market influence 1921), and hedges 1912 may be checked for type 1917 and alpha 1922 information.", "FIG.", "20 is an exemplary decision tree 2000, according to an embodiment of the invention.", "According to the embodiment, asset allocation 2001 may be examined for asset type 2002 and then to determine where any determined variance is coming from 2003.Equities 2004 may be checked for their value 2010 and growth 2009, as well as their growth potential (for example, whether they are large 2015 or mid 2016 growth equities, or other growth capital types).", "Bonds 2005 may be checked for their type 2011 and potential performance drags 2017, and commodities 2006 may be checked for timing and holding data 2012 as well as alpha data 2018.Market influence 2007 may be checked for upside or downside capture information 2013 (and if downside, then it can be determined that any performance is not due to market influence 2019), and hedges 2008 may be checked for type 2014 and alpha 2020 information.", "FIG.", "21 an exemplary decision tree 2100, according to an embodiment of the invention.", "According to the embodiment, when a user enters a trade 2101, data lots may be collected 2102 for the trade and recorded 2103, and may then be analyzed to identify patterns 2104.From this analysis, patterns and probabilities may be determined 2105 and used for future trades 2106 to notify a user based on their trade history and performance.", "The user may then enter a new trade 2107, which may optionally be the same trade (if they do not wish to alter their trade after reviewing performance data), and view any suggestions based on the new trade 2108, resulting in improved trading 2109 through the use of analysis and live suggestions for improving performance based on past data and analysis results.", "FIG.", "22 is a conceptual diagram 2200 showing different asset classes and goals, according to an embodiment of the invention.", "According to the embodiment, financial growth 2201 may be derived from a hierarchy of contributing factors, from low-risk secure investments (such as, for example, physical investments like a bomb shelter 2207, low-risk municipal bonds 2208 or high-grade corporate investments 2209), the focus on low volume and consistency 2206 for medium-duration cash flow 2205, to large-capital multi-net income investments 2204 focusing on cash flow equity 2203, and analysis to identify missing elements 2202 to encourage growth through intelligent analysis and user notification to improve performance.", "FIG.", "23 is an illustration of an exemplary user interface for a virtual assistant application, illustrating an exemplary proactive notification display and a user portfolio management interface, according to a preferred embodiment of the invention.", "In a notification display 2310, a notification may be presented to a user as a popup within an application, or a push notification to their mobile device, or similar notification functionality according to their device capabilities or preferences.", "A notification may present the user with a brief summary of an event 2311, such as an alert about an event that may affect them, or a suggestion based on deep analysis, and may present a user with a plurality of interactive indicia 2312 to view additional information, such as displaying folder tabs corresponding to related information for the notification.", "For example, in a notification offering a finance suggestion such as a way to improve a trade, a user may be shown indicia to view their portfolio information 2320, or to view market information 2330, so that they may review the information before deciding how to respond to the notification.", "In a portfolio view 2320, a user may view various information related to their financial analysis that may be used to produce notifications and offer suggestions.", "A calendar 2321 may show events the user should be aware of, such as earnings dates, macro events, political events, or other such events that may affect their portfolio.", "A user may also view their portfolio allocation graphically 2322, as well as a plurality of graphical representations of portfolio performance against selected benchmarks 2323.A slider 2324 or other scalar element may be presented to allow a user to adjust the sensitivity for future alerts, for example to prevent unnecessary notifications over minor events or to increase sensitivity for alerts pertaining to specific elements of their portfolio.", "In a market view 2330, a user may view market information pertaining to their portfolio or a particular trade, or information relevant to a particular notification such as market changes that were used in the analysis that led to the generation of an alert.", "A plurality of relevant stocks or commodities may be shown 2331, along with selection indicia 2332 for a user to select whether or not they wish to be notified of changes and events pertaining to a particular stock.", "For example, a user may wish to follow stocks in which they have not invested, to keep an eye on the market for future investment opportunities.", "To do this, a user may manually select stocks to follow for notifications even though they are not directly involved with those stocks (and thus would not be notified of changes as part of regular handling, as described above with reference to FIG.", "8).", "FIG.", "25 is a diagram of an exemplary system architecture, illustrating the use of a mixed audio and visual interaction system for financial information notification and retrieval according to an embodiment of the invention.", "When so configured, the system may audibly announce some portion of a push message or notification in natural language 2500.In this situation, push message and notification or alert information may be sent from the virtual assistant across the internet or other data network in use 2501 to client internal networks 2520 and devices 2510, 2530, 2540, 2550.One or more of these devices, including a device specifically designed for audio type interaction, an “audio mode client” here 2510, may be configured to verbally announce some identifying portion of the notification or push message such as but not limited to a title; or all, or part of a summary as per previous client configuration.", "In some system configurations such audio mode clients 2510 may be placed at locations throughout a client's dwelling.", "Other configurations may also allow the client's desktop computers 2530, laptop computers 2550 and mobile devices such as, but not limited, to smart phones and tablets 2540 to make natural language announcements with audio announcements being controlled on these devices through easy to reach preference panels.", "Of course, the natural language announcements would make use of one or more speakers either integral or externally connected to the device 2511, 2531, 2541, 2551.To these natural language audio announcements, a client may respond with a set of commands using a microphone connected to the client device in use 2512, 2532, 2542, 2552 to perform simple notification related tasks.", "For example, “Show me.” may be used to open one or more virtual assistant related application windows and to display the full notification and the immediate background information on the default designated client display device, for example the client's desktop workstation, or the current device, if display capable.", "The client may also specify the device on which to display the desired information, for example “Show me on den computer.” 2530 or “Show me on my laptop.” 2550.The client may also stipulate simple items that she wants to investigate.", "For example, if the notification pertains to Stock X the client might say “Show me the performance of Stock X over past six months as a table of weekly end prices (on my laptop).” Or if the notification is that a stock of interest, “Stock Y” has reached a pre-decided buy or sell level, the client may say “Confirm sell Stock Y.” or “Confirm buy Stock Y.” or “Hold Stock Y, Show me Stock Y performance for past 6 months and expert opinion data for Stock Y.” Verbal commands can quickly reach complexity where traditional keyboard and icon interaction may be more efficient and some tasks may not lend themselves to efficient verbal description.", "Only a very small subset of useful verbal interaction have been disclosed here, but the invention may respond to any commands found useful to those skilled in the art.", "FIG.", "26 is a flow diagram illustrating exemplary function of the mixed audio and visual interaction method available for financial information retrieval 2600 according to a preferred embodiment of the invention.", "Push notification information is received from the virtual assistant platform by one or more of the user's client devices 2601.If the client has audio interaction activated 2602 for an audio interaction capable device then that device will audibly announce some predetermined portion of the push notification which may be a title, or all or part of a summary according to pre-set client preferences 2604.Otherwise, normal visual only handling will take place according to client preferences, which may include an audio alert tone but no speech interaction 2603.The client device will then listen for the user's response in the form of a known command.", "If, after a certain no commands are received 2607, the notification will be labeled as unhandled 2608 which may be further processed per user preference choice.", "Valid voice commands may be the client asking to be shown the full notification and/or the supporting data 2606 otherwise, valid commands may request that other actions be taken such as, but not limited to: “Save until 3:00 pm.”, “Confirm sell Stock X”, “Show me expert opinion data for Stock X from last 6 months.”, or “Show performance data of Stock X for last 6 months as a line graph.” 2609 The system may be programmed to accept any verbal command known useful to one skilled in the art.", "The client may have multiple devices on which verbal command requested data may be displayed and may specify a display at the time of initial response such as: “Show me on den workstation.” 2610, in which case an application window will be opened on that device and focus shifted there 2615.If no client display device is specified and the device in current use has display capabilities 2611, it may be assumed by the system that visual results are to be shown there 2614.Otherwise, if no device is specified by the client 2610 and the current device does not have adequate display capabilities, the system may ask the client to specify a device 2612 on which to display the notification data 2613.FIG.", "24 is a block diagram of an exemplary system architecture 2400, illustrating the integration of a virtual assistant with deep analytics and proactive interaction with third-party virtual assistant products to extend their functionality.", "According to the embodiment, virtual assistant platform 110 may connect via the Internet 120 or other data communication network, to interact with a user device 140 (for example, a user's smartphone or computer) and a plurality of data sources 130 that may comprise a wide variety of information sources such as user financial accounts 131 (such as investment portfolios or bank accounts), social media profiles 132, accounts with service providers 133 such as public utilities or cloud services, news or other media sources 134, and other various sources of available information, whether public or private (with corresponding configuration for access).", "Data from sources 130 may be exposed using a plurality of application programming interfaces (APIs) 111 configured to facilitate communication between data sources 130 and a data collector 112 that receives raw data from connected data sources 130 and stores the data in a raw data storage database 113.This raw data may then be processed by an analysis engine 114 to produce entities for internal use such as to maintain a hierarchical structure as described below, as well as to identify any information changes such as new data or modifications to previously-received data (for example, when a stock price changes, or new posts are uploaded to a social media account, or new travel arrangements are made).", "Processed data may then be placed in a processed information storage database 115, which may optionally be a separate database structure or physical storage from a raw storage 113, or may simply be a logical separation within the same storage schema.", "An intelligent advisor 117 may then retrieve processed data from storage 115 and load configured rules from a rules database 116 (such as rules governing a user's preferences for notifications, thresholds for determining whether a change is significant, timing for updates, or other such configuration information), and may analyze the data to identify relationships between data points (such as identifying that a user has family nearby a newly-booked travel destination, or that they have invested in a company that was mentioned in a recent news article) and to determine (optionally based on a plurality of configured rules) whether any particular change will impact related data entities and whether a user should be notified.", "For example, if a news article mentions a company in which the user holds stock, but it is only a passing reference, the user may not be notified as the implications of this observation are negligible.", "However, if a news article discusses a potential merger between companies, or a change in a product timeline, a user may be notified as this news may impact their stock.", "Notification prompts may then be provided to a messaging server 118 that may operate a plurality of messaging interfaces to accommodate a wide range of user preferences such as to communicate via email, SMS, SKYPE™, push notifications to a user's smartphone or other mobile device, or other such communication methods.", "Notifications may then be produced and transmitted via network 120 to a user's device 140 for review.", "API layer 111 may operate a plurality of APIs configured to provide integration with third-party virtual assistant services 2420a-n or devices 2410a-n to extend their functionality, for example to provide deep analysis and proactive interaction to existing assistant technologies and to enable third parties to extend their own solutions by offering the additional functionality of a deep-analysis proactive virtual assistant system 110 within their own products.", "For example, a virtual assistant service 2420a-n such as MICROSOFT CORTANA™ may utilize proactive notification functionality using deep analysis, by incorporating a user's linked accounts and known information that is already available to the service, and applying the techniques and algorithms disclosed herein to uncover additional insights and offer proactive suggestions to users.", "For example, when a user is traveling near the home of a family member, they may be prompted to visit without having to manually input the family member's information or manually checking scheduling.", "In another example, a virtual assistant device 2410a-n such as AMAZON ECHO™ may be used to present proactive notifications and respond to user interaction in new ways using deep analysis to expand the device's capabilities beyond its original functions.", "For example, a user may ask an AMAZON ECHO™ device “How did my stocks do today?” and receive a meaningful, personalized response based on deep analysis of their portfolio.", "The device may also be used to deliver notifications, such as alerts based on situational awareness notifying the user of changes or events that may affect them, rather than traditional operation wherein such devices and services operate in a reactive-only operation mode, wherein a user must ask a question or otherwise interact in order to receive any form of feedback from the virtual assistant.", "Hardware Architecture Generally, the techniques disclosed herein may be implemented on hardware or a combination of software and hardware.", "For example, they may be implemented in an operating system kernel, in a separate user process, in a library package bound into network applications, on a specially constructed machine, on an application-specific integrated circuit (ASIC), or on a network interface card.", "Software/hardware hybrid implementations of at least some of the embodiments disclosed herein may be implemented on a programmable network-resident machine (which should be understood to include intermittently connected network-aware machines) selectively activated or reconfigured by a computer program stored in memory.", "Such network devices may have multiple network interfaces that may be configured or designed to utilize different types of network communication protocols.", "A general architecture for some of these machines may be described herein in order to illustrate one or more exemplary means by which a given unit of functionality may be implemented.", "According to specific embodiments, at least some of the features or functionalities of the various embodiments disclosed herein may be implemented on one or more general-purpose computers associated with one or more networks, such as for example an end-user computer system, a client computer, a network server or other server system, a mobile computing device (e.g., tablet computing device, mobile phone, smartphone, laptop, or other appropriate computing device), a consumer electronic device, a music player, or any other suitable electronic device, router, switch, or other suitable device, or any combination thereof.", "In at least some embodiments, at least some of the features or functionalities of the various embodiments disclosed herein may be implemented in one or more virtualized computing environments (e.g., network computing clouds, virtual machines hosted on one or more physical computing machines, or other appropriate virtual environments).", "Referring now to FIG.", "4, there is shown a block diagram depicting an exemplary computing device 10 suitable for implementing at least a portion of the features or functionalities disclosed herein.", "Computing device 10 may be, for example, any one of the computing machines listed in the previous paragraph, or indeed any other electronic device capable of executing software- or hardware-based instructions according to one or more programs stored in memory.", "Computing device 10 may be configured to communicate with a plurality of other computing devices, such as clients or servers, over communications networks such as a wide area network a metropolitan area network, a local area network, a wireless network, the Internet, or any other network, using known protocols for such communication, whether wireless or wired.", "In one embodiment, computing device 10 includes one or more central processing units (CPU) 12, one or more interfaces 15, and one or more busses 14 (such as a peripheral component interconnect (PCI) bus).", "When acting under the control of appropriate software or firmware, CPU 12 may be responsible for implementing specific functions associated with the functions of a specifically configured computing device or machine.", "For example, in at least one embodiment, a computing device 10 may be configured or designed to function as a server system utilizing CPU 12, local memory 11 and/or remote memory 16, and interface(s) 15.In at least one embodiment, CPU 12 may be caused to perform one or more of the different types of functions and/or operations under the control of software modules or components, which for example, may include an operating system and any appropriate applications software, drivers, and the like.", "CPU 12 may include one or more processors 13 such as, for example, a processor from one of the Intel, ARM, Qualcomm, and AMD families of microprocessors.", "In some embodiments, processors 13 may include specially designed hardware such as application-specific integrated circuits (ASICs), electrically erasable programmable read-only memories (EEPROMs), field-programmable gate arrays (FPGAs), and so forth, for controlling operations of computing device 10.In a specific embodiment, a local memory 11 (such as non-volatile random access memory (RAM) and/or read-only memory (ROM), including for example one or more levels of cached memory) may also form part of CPU 12.However, there are many different ways in which memory may be coupled to system 10.Memory 11 may be used for a variety of purposes such as, for example, caching and/or storing data, programming instructions, and the like.", "It should be further appreciated that CPU 12 may be one of a variety of system-on-a-chip (SOC) type hardware that may include additional hardware such as memory or graphics processing chips, such as a QUALCOMM SNAPDRAGON™ or SAMSUNG EXYNOS™ CPU as are becoming increasingly common in the art, such as for use in mobile devices or integrated devices.", "As used herein, the term “processor” is not limited merely to those integrated circuits referred to in the art as a processor, a mobile processor, or a microprocessor, but broadly refers to a microcontroller, a microcomputer, a programmable logic controller, an application-specific integrated circuit, and any other programmable circuit.", "In one embodiment, interfaces 15 are provided as network interface cards (NICs).", "Generally, NICs control the sending and receiving of data packets over a computer network; other types of interfaces 15 may for example support other peripherals used with computing device 10.Among the interfaces that may be provided are Ethernet interfaces, frame relay interfaces, cable interfaces, DSL interfaces, token ring interfaces, graphics interfaces, and the like.", "In addition, various types of interfaces may be provided such as, for example, universal serial bus (USB), Serial, Ethernet, FIREWIRE™, THUNDERBOLT™, PCI, parallel, radio frequency (RF), BLUETOOTH™, near-field communications (e.g., using near-field magnetics), 802.11 (WiFi), frame relay, TCP/IP, ISDN, fast Ethernet interfaces, Gigabit Ethernet interfaces, Serial ATA (SATA) or external SATA (ESATA) interfaces, high-definition multimedia interface (HDMI), digital visual interface (DVI), analog or digital audio interfaces, asynchronous transfer mode (ATM) interfaces, high-speed serial interface (HSSI) interfaces, Point of Sale (POS) interfaces, fiber data distributed interfaces (FDDIs), and the like.", "Generally, such interfaces 15 may include physical ports appropriate for communication with appropriate media.", "In some cases, they may also include an independent processor (such as a dedicated audio or video processor, as is common in the art for high-fidelity AN hardware interfaces) and, in some instances, volatile and/or non-volatile memory (e.g., RAM).", "Although the system shown in FIG.", "4 illustrates one specific architecture for a computing device 10 for implementing one or more of the inventions described herein, it is by no means the only device architecture on which at least a portion of the features and techniques described herein may be implemented.", "For example, architectures having one or any number of processors 13 may be used, and such processors 13 may be present in a single device or distributed among any number of devices.", "In one embodiment, a single processor 13 handles communications as well as routing computations, while in other embodiments a separate dedicated communications processor may be provided.", "In various embodiments, different types of features or functionalities may be implemented in a system according to the invention that includes a client device (such as a tablet device or smartphone running client software) and server systems (such as a server system described in more detail below).", "Regardless of network device configuration, the system of the present invention may employ one or more memories or memory modules (such as, for example, remote memory block 16 and local memory 11) configured to store data, program instructions for the general-purpose network operations, or other information relating to the functionality of the embodiments described herein (or any combinations of the above).", "Program instructions may control execution of or comprise an operating system and/or one or more applications, for example.", "Memory 16 or memories 11, 16 may also be configured to store data structures, configuration data, encryption data, historical system operations information, or any other specific or generic non-program information described herein.", "Because such information and program instructions may be employed to implement one or more systems or methods described herein, at least some network device embodiments may include nontransitory machine-readable storage media, which, for example, may be configured or designed to store program instructions, state information, and the like for performing various operations described herein.", "Examples of such nontransitory machine-readable storage media include, but are not limited to, magnetic media such as hard disks, floppy disks, and magnetic tape; optical media such as CD-ROM disks; magneto-optical media such as optical disks, and hardware devices that are specially configured to store and perform program instructions, such as read-only memory devices (ROM), flash memory (as is common in mobile devices and integrated systems), solid state drives (SSD) and “hybrid SSD” storage drives that may combine physical components of solid state and hard disk drives in a single hardware device (as are becoming increasingly common in the art with regard to personal computers), memristor memory, random access memory (RAM), and the like.", "It should be appreciated that such storage means may be integral and non-removable (such as RAM hardware modules that may be soldered onto a motherboard or otherwise integrated into an electronic device), or they may be removable such as swappable flash memory modules (such as “thumb drives” or other removable media designed for rapidly exchanging physical storage devices), “hot-swappable” hard disk drives or solid state drives, removable optical storage discs, or other such removable media, and that such integral and removable storage media may be utilized interchangeably.", "Examples of program instructions include both object code, such as may be produced by a compiler, machine code, such as may be produced by an assembler or a linker, byte code, such as may be generated by for example a JAVA™ compiler and may be executed using a Java virtual machine or equivalent, or files containing higher level code that may be executed by the computer using an interpreter (for example, scripts written in Python, Perl, Ruby, Groovy, or any other scripting language).", "In some embodiments, systems according to the present invention may be implemented on a standalone computing system.", "Referring now to FIG.", "5, there is shown a block diagram depicting a typical exemplary architecture of one or more embodiments or components thereof on a standalone computing system.", "Computing device 20 includes processors 21 that may run software that carry out one or more functions or applications of embodiments of the invention, such as for example a client application 24.Processors 21 may carry out computing instructions under control of an operating system 22 such as, for example, a version of MICROSOFT WINDOWS™ operating system, APPLE OSX™ or iOS™ operating systems, some variety of the Linux operating system, ANDROID™ operating system, or the like.", "In many cases, one or more shared services 23 may be operable in system 20, and may be useful for providing common services to client applications 24.Services 23 may for example be WINDOWS™ services, user-space common services in a Linux environment, or any other type of common service architecture used with operating system 21.Input devices 28 may be of any type suitable for receiving user input, including for example a keyboard, touchscreen, microphone (for example, for voice input), mouse, touchpad, trackball, or any combination thereof.", "Output devices 27 may be of any type suitable for providing output to one or more users, whether remote or local to system 20, and may include for example one or more screens for visual output, speakers, printers, or any combination thereof.", "Memory 25 may be random-access memory having any structure and architecture known in the art, for use by processors 21, for example to run software.", "Storage devices 26 may be any magnetic, optical, mechanical, memristor, or electrical storage device for storage of data in digital form (such as those described above, referring to FIG.", "4).", "Examples of storage devices 26 include flash memory, magnetic hard drive, CD-ROM, and/or the like.", "In some embodiments, systems of the present invention may be implemented on a distributed computing network, such as one having any number of clients and/or servers.", "Referring now to FIG.", "6, there is shown a block diagram depicting an exemplary architecture 30 for implementing at least a portion of a system according to an embodiment of the invention on a distributed computing network.", "According to the embodiment, any number of clients 33 may be provided.", "Each client 33 may run software for implementing client-side portions of the present invention; clients may comprise a system 20 such as that illustrated in FIG.", "5.In addition, any number of servers 32 may be provided for handling requests received from one or more clients 33.Clients 33 and servers 32 may communicate with one another via one or more electronic networks 31, which may be in various embodiments any of the Internet, a wide area network, a mobile telephony network (such as CDMA or GSM cellular networks), a wireless network (such as WiFi, WiMAX, LTE, and so forth), or a local area network (or indeed any network topology known in the art; the invention does not prefer any one network topology over any other).", "Networks 31 may be implemented using any known network protocols, including for example wired and/or wireless protocols.", "In addition, in some embodiments, servers 32 may call external services 37 when needed to obtain additional information, or to refer to additional data concerning a particular call.", "Communications with external services 37 may take place, for example, via one or more networks 31.In various embodiments, external services 37 may comprise web-enabled services or functionality related to or installed on the hardware device itself.", "For example, in an embodiment where client applications 24 are implemented on a smartphone or other electronic device, client applications 24 may obtain information stored in a server system 32 in the cloud or on an external service 37 deployed on one or more of a particular enterprise's or user's premises.", "In some embodiments of the invention, clients 33 or servers 32 (or both) may make use of one or more specialized services or appliances that may be deployed locally or remotely across one or more networks 31.For example, one or more databases 34 may be used or referred to by one or more embodiments of the invention.", "It should be understood by one having ordinary skill in the art that databases 34 may be arranged in a wide variety of architectures and using a wide variety of data access and manipulation means.", "For example, in various embodiments one or more databases 34 may comprise a relational database system using a structured query language (SQL), while others may comprise an alternative data storage technology such as those referred to in the art as “NoSQL” (for example, HADOOP CASSANDRA™, GOOGLE BIGTABLE™, and so forth).", "In some embodiments, variant database architectures such as column-oriented databases, in-memory databases, clustered databases, distributed databases, or even flat file data repositories may be used according to the invention.", "It will be appreciated by one having ordinary skill in the art that any combination of known or future database technologies may be used as appropriate, unless a specific database technology or a specific arrangement of components is specified for a particular embodiment herein.", "Moreover, it should be appreciated that the term “database” as used herein may refer to a physical database machine, a cluster of machines acting as a single database system, or a logical database within an overall database management system.", "Unless a specific meaning is specified for a given use of the term “database”, it should be construed to mean any of these senses of the word, all of which are understood as a plain meaning of the term “database” by those having ordinary skill in the art.", "Similarly, most embodiments of the invention may make use of one or more security systems 36 and configuration systems 35.Security and configuration management are common information technology (IT) and web functions, and some amount of each are generally associated with any IT or web systems.", "It should be understood by one having ordinary skill in the art that any configuration or security subsystems known in the art now or in the future may be used in conjunction with embodiments of the invention without limitation, unless a specific security 36 or configuration system 35 or approach is specifically required by the description of any specific embodiment.", "FIG.", "7 shows an exemplary overview of a computer system 40 as may be used in any of the various locations throughout the system.", "It is exemplary of any computer that may execute code to process data.", "Various modifications and changes may be made to computer system 40 without departing from the broader scope of the system and method disclosed herein.", "Central processor unit (CPU) 41 is connected to bus 42, to which bus is also connected memory 43, nonvolatile memory 44, display 47, input/output (I/O) unit 48, and network interface card (NIC) 53.I/O unit 48 may, typically, be connected to keyboard 49, pointing device 50, hard disk 52, and real-time clock 51.NIC 53 connects to network 54, which may be the Internet or a local network, which local network may or may not have connections to the Internet.", "Also shown as part of system 40 is power supply unit 45 connected, in this example, to a main alternating current (AC) supply 46.Not shown are batteries that could be present, and many other devices and modifications that are well known but are not applicable to the specific novel functions of the current system and method disclosed herein.", "It should be appreciated that some or all components illustrated may be combined, such as in various integrated applications, for example Qualcomm or Samsung system-on-a-chip (SOC) devices, or whenever it may be appropriate to combine multiple capabilities or functions into a single hardware device (for instance, in mobile devices such as smartphones, video game consoles, in-vehicle computer systems such as navigation or multimedia systems in automobiles, or other integrated hardware devices).", "In various embodiments, functionality for implementing systems or methods of the present invention may be distributed among any number of client and/or server components.", "For example, various software modules may be implemented for performing various functions in connection with the present invention, and such modules may be variously implemented to run on server and/or client components.", "The skilled person will be aware of a range of possible modifications of the various embodiments described above.", "Accordingly, the present invention is defined by the claims and their equivalents." ] ]
Patent_15872559
[ [ "FOCUS ASSIST SYSTEM AND METHOD", "According to some aspects, a method for assisting the adjusting of a focus of an image includes providing a graphical representation of a detected image.", "The method can also include receiving an indication of a user selection of a region of the image and providing a magnified graphical representation of the selected image region.", "The method may further include providing a graphical indication of a degree of focus for at least a portion of the selected image region.", "The graphical indication in some instances is visually correlated with the magnified graphical representation of the selected image region.", "The size, shape, and/or color of the graphical indication in some instances can be correlated with the degree of focus for at least a portion of the selected image region." ], [ "1-20.", "(canceled) 21.An apparatus that assists in adjusting a focus of an image, the apparatus comprising: an image sensor configured to detect an image; and one or more processors programmed to: determine that a focus of a focus region of an image is at a first focus level; generate a first visual indication of the first focus level; generate a second visual indication of the first focus level, the second visual indication being different in shape than the first visual indication; generate a graphical representation of the image; output, for presentation on a display, the graphical representation together with the first visual indication and the second visual indication so that the first visual indication and the second visual indication are overlaid on the graphical representation and positions of the first visual indication and the second visual indication on the graphical representation depend on a location of the focus region within the image; detect a first user adjustment of the focus of the focus region from the first focus level to a second focus level subsequent to the output of the graphical representation together with the first visual indication and the second visual indication; and in response detecting the first user adjustment, change the first visual indication from a first color to a second color different from the first color to visually indicate that the focus of the focus region is at the second focus level rather than at the first focus level, and change the second visual indication to visually indicate that the focus of the focus region is at the second focus level rather than at the first focus level.", "22.The apparatus of claim 21, wherein the image comprises the focus region and a non-focus region different from the focus region, and at least part of a graphical representation of the focus region is within an interior area defined by the first visual indication.", "23.The apparatus of claim 22, wherein the interior area is rectangular.", "24.The apparatus of claim 21, wherein the one or more processors is programmed to change of the second visual indication by making one or more intermediate adjustments to the second visual indication corresponding to one or more intermediate focus levels between the first focus level and the second focus level.", "25.The apparatus of claim 21, wherein the second focus level is more in focus than the first focus level, and the one or more processors is programmed to change the second visual indication by converging points on the second visual indication with respect to other points on the second visual indication to visually convey an increase in the focus of the focus region.", "26.The apparatus of claim 21, wherein the one or more processors is programmed to change the second visual indication by changing a shape of the second visual indication.", "27.The apparatus of claim 21, wherein the one or more processors is programmed to change the first and second visual indications in real time with the first user adjustment.", "28.The apparatus of claim 21, wherein the second focus level is more in focus than the first focus level, and the second color is green.", "29.The apparatus of claim 21, wherein the second visual indication comprises a polygon.", "30.The apparatus of claim 21, wherein the second visual indication comprises a plurality of triangles.", "31.The apparatus of claim 21, wherein the one or more processors is programmed to determine the focus of the focus region in response to a user selection of the focus region received via a user interface.", "32.The apparatus of claim 21, further comprising a camera housing and the display, the camera housing being configured to support the image sensor, the one or more processors, and the display.", "33.The apparatus of claim 21, wherein the one or more processors is further programmed to: detect a second user adjustment of the focus of the focus region from the second focus level to the first focus level subsequent to detecting the first user adjustment; and in response to detecting the second user adjustment, change the first visual indication from the second color to the first color to visually indicate that the focus of the focus region is at the first focus level rather than at the second focus level, and change the second visual indication to visually indicate that the focus of the focus region is at the first focus level rather than at the second focus level.", "34.A method on assisting in adjusting a focus of an image, comprising: detecting an image with an image sensor; determining that a focus of a focus region of the image is at a first focus level; generating a first visual indication of the first focus level; generating a second visual indication of the first focus level, the second visual indication being different in shape than the first visual indication; generating a graphical representation of the image; outputting, for presentation on a display, the graphical representation together with the first visual indication and the second visual indication so that the first visual indication and the second visual indication are overlaid on the graphical representation and positions of the first visual indication and the second visual indication on the graphical representation depend on a location of the focus region within the image; detecting a first user adjustment of the focus of the focus region from the first focus level to a second focus level subsequent to said outputting the graphical representation together with the first visual indication and the second visual indication; and in response said detecting the first user adjustment, changing the first visual indication from a first color to a second color different from the first color to visually indicate that the focus of the focus region is at the second focus level rather than at the first focus level, and changing the second visual indication to visually indicate that the focus of the focus region is at the second focus level rather than at the first focus level.", "35.The method of claim 34, wherein the image comprises the focus region and a non-focus region different from the focus region, and at least part of a graphical representation of the focus region is within an interior area defined by the first visual indication.", "36.The method of claim 34, wherein said changing the second visual indication comprises making one or more intermediate adjustments to the second visual indication corresponding to one or more intermediate focus levels between the first focus level and the second focus level.", "37.The method of claim 34, wherein the second focus level is more in focus than the first focus level, and said changing the second visual indication comprises converging points on the second visual indication with respect to other points on the second visual indication to visually convey an increase in the focus of the focus region.", "38.The method of claim 34, wherein the second focus level is more in focus than the first focus level, and the second color is green.", "39.The method of claim 34, wherein the second visual indication comprises a plurality of triangles.", "40.The method of claim 34, further comprising: detecting a second user adjustment of the focus of the focus region from the second focus level to the first focus level subsequent to said detecting the first user adjustment; and in response to said detecting the second user adjustment, changing the first visual indication from the second color to the first color to visually indicate that the focus of the focus region is at the first focus level rather than at the second focus level, and changing the second visual indication to visually indicate that the focus of the focus region is at the first focus level rather than at the second focus level." ], [ "<SOH> BACKGROUND <EOH>The invention relates to providing focus information.", "There are two basic methods of focusing a camera or optical instrument.", "In an autofocus system, the camera sets the focus level with little or no user input.", "The camera collects data about the relative focus level of objects in the camera lens.", "It uses an algorithm to interpret that data and set an optimum focus level.", "However, this algorithm does not necessarily execute the photographer's intentions.", "Many autofocus algorithms prioritize objects that are close to the center of the frame or that are brightly lit.", "If the object of the photographer's interest is off-center or dimly lit, the autofocus algorithm may calibrate a focus level based on objects in which the photographer has no interest.", "Manual focus cameras require more effort from the user.", "But, they also give the photographer more control over the focus level.", "Because manual focus cameras are more responsive to the user's wishes and potentially more precise, professionals often use manual focus cameras.", "Whichever system a camera employs—autofocus or manual focus—the ability of the system to yield desirable results depends on the user's ability to confirm which objects are in or out of focus.", "In an autofocus system, if it is unclear which objects are in or out of focus, the user cannot confirm that the autofocus algorithm has identified the user's primary objects of interest and set the focus level accordingly.", "In a manual focus system, if a user cannot confirm which objects are in or out of focus, the user cannot confirm the precision of focus adjustments.", "Camera displays may be too small or imprecise to reliably convey to the user whether or not an object is in focus, or if out of focus, just how much out of focus.", "They do not often allow the user to distinguish between gradations in the focus level or balance the focus level between multiple objects in the viewfinder." ], [ "<SOH> SUMMARY <EOH>An optical lens having a variable focal length is used to detect an image.", "The lens focuses the image on a sensor, and the sensor captures information corresponding to individual picture elements (pixels).", "A display shows the detected image.", "In order to assist a user to adjust the focus of the image, a waveform indicates a degree of focus.", "The waveform may be superimposed on the image, or may be displayed adjacent to the image.", "Alternatively, the waveform may be displayed on a separate screen.", "The waveform is updated in real-time, allowing the user to adjust the focus contemporaneously.", "The display of the degree of focus could be used, e.g., for still cameras and motion picture cameras.", "The optical sensor converts the image from the lens into a two-dimensional, digital array of pixels, with the array of pixels arranged in rows and columns.", "In one embodiment, a processor operates on a row of pixels to determine focus level data for a plurality of pixels in that row.", "The waveform may indicate the degree of focus through color variations, intensity variations, density variations, amplitude variations, or other visual indicia.", "A combination of different types of indicia may be used.", "The focus level data may be determined, for example, with an edge detection algorithm.", "In one embodiment, the focus level data is determined by comparing at least a portion of the digital array of pixels with a blurred rendition of the same portion of the array.", "In one embodiment, an image is detected using a two-dimensional array of optical sensors.", "The detected image is converted into a data structure that represents the detected image as a two-dimensional array of pixel values, where the pixel values are representative of an amount of light detected by the optical sensors.", "A blurred image is generated by combining a selected pixel value with a plurality of pixel values from the vicinity of the selected pixel value.", "The degree of focus is then determined by comparing the selected pixel value with a corresponding blurred image pixel value.", "A visual indication of the degree of focus is then provided.", "In one embodiment, the visual indication of the degree of focus may be overlaid on a representation of the detected image.", "In another embodiment, the visual indication of the degree of focus is adjacent to a representation of the detected image.", "Providing the visual indication of the degree of focus may comprise displaying a waveform corresponding to the degree of focus.", "A point on the waveform may correspond to an average degree of focus for a plurality of vertically aligned pixels.", "In another embodiment, a point on the waveform may correspond to an average degree of focus for a plurality of horizontally aligned pixels.", "In yet another embodiment, a point on the waveform may correspond to an average degree of focus for a plurality of pixels in a block.", "In a further embodiment, a point on the waveform corresponds to an average degree of focus for a plurality of non-adjacent pixels.", "In one embodiment, a method of providing feedback to allow focusing an image in real time comprises using a programmed algorithm to determine a degree of focus of a plurality of regions and providing a visual indication of the degree of focus of each region.", "The visual indication may take a variety of formats, such as, for example, a waveform, varying the relief of a region, or indication of focus by a geometric figure.", "The region may be, for example, a line or a regular geometric pattern.", "In one embodiment, the degree of focus of a region may indicated by varying the color of the region.", "In another embodiment, the degree of focus of a region may be indicated by varying the brightness of the region.", "The regions may be described by edge detection, and the degree of focus of each region may be indicated by varying, e.g., the brightness or color of an edge.", "According to further aspects, a method for assisting the adjusting of a focus of an image includes providing a graphical representation of a detected image.", "The method can also include receiving an indication of a user selection of a region of the image and providing a magnified graphical representation of the selected image region.", "The method may further include providing a graphical indication of a degree of focus for at least a portion of the selected image region.", "The graphical indication in some instances is visually correlated with the magnified graphical representation of the selected image region.", "According to further aspects, a method for assisting the adjusting of a focus of an image includes detecting an image and providing a graphical representation of the image.", "The method further includes receiving an indication of a user selection of a first portion of the image.", "The method can also include applying an algorithm operating on one or more processors to determine focus levels for one or more regions of the first portion of the image.", "In response to the user selection, the method can include providing a visual indication of the focus levels.", "In some additional embodiments, an apparatus assists in adjusting a focus of an image.", "The apparatus can include a lens having variable focal length.", "The lens produces a visual data image from light that enters the lens.", "The apparatus can also include a manual focus adjustment that adjusts the focal length of the lens and an optical sensor that converts the visual data image from the lens into a digital representation of the image.", "The apparatus may further include a display configured to show a graphical representation of the image.", "The apparatus can also include an interface configured to receive a user selection of a first portion of the image.", "In some instances, the apparatus further includes one or more processors configured to process the digital representation of the image to determine focus levels for one or more regions of the first portion.", "Additionally, the display can provide a visual indication of the focus levels.", "In some embodiments, a visual indication of a degree of focus of a region of an image is provided.", "In some embodiments, the visual indication of the degree of focus of the region or all or part of the image may be overlaid on a representation of the detected image.", "The visual indication can be overlaid on the representation of the detected image so that the center of the visual indication coincides with the center of the region of the image for which the degree of focus is visually indicated.", "The visual indication can be configured to change size, shape, and/or color in response to changes in the degree of focus.", "In some implementations, the visual indication decreases in size corresponding to an increase in the degree of focus of the region of the image.", "The visual indication can change color in response to changes in degrees of focus.", "The visual indication can change shape in response to changes in degrees of focus.", "The region of the image can be selected by a user.", "In some embodiments, a second visual indication can be overlaid on the representation of the detected image.", "The second visual indication can be configured to change color corresponding to changes in the degree of focus.", "The size of the second visual indication can correspond to the size of the region of the image for which the degree of focus is visually indicated.", "In some embodiments, multiple regions can be selected and corresponding visual indicators can be provided overlaid on the representation of the detected image.", "Although described with respect to particular example visual indications, other forms of visual indications are compatible with the techniques described herein.", "In some embodiments, a method for indicating a focus of a region of an image is provided.", "The method includes determining a degree of focus for a region of the image and providing a visual indication of the degree of focus.", "In response to a change in the degree of focus, the size of the visual indication can be changed, wherein the size of the visual indication is correlated to the degree of focus.", "In some embodiments, the size of the visual indication transitions from a first size to a second size based on a change from a first degree of focus to a second degree of focus.", "The transition can include adjusting the size of the visual indication to one or more intermediate sizes during the transition from the first size to the second size, the intermediate sizes being between the first size and the second size and corresponding to intermediate focus levels between the first degree of focus and the second degree of focus.", "In some embodiments, a degree of focus for a second region of the image is determined.", "A second visual indication of the degree of focus for the second region can be provided wherein the size of the second visual indication changes in response to a change in the degree of focus for the second region, wherein the size of the second visual indication is correlated to a current degree of focus.", "In some embodiments, an apparatus that assists in adjusting a focus of an image is provided.", "The apparatus can include an image sensor for detecting an image and one or more processors for determining a degree of focus for a region of the image.", "The apparatus can also include a display configured to show a graphical representation of the detected image and to show a visual indication of the degree of focus of the region, the visual indication having a size that is correlated to the degree of focus of the region.", "In some embodiments, a method for assisting the adjusting of a focus of an image is provided.", "The method can include detecting an image using at least one imaging sensor and providing a graphical representation of the image on a display.", "The method can further include receiving an indication of a user selection of a first portion of the displayed image and providing a magnified view of the first portion on the display.", "The method can include applying an algorithm operating on one or more processors to determine a degree of focus for at least two regions within the first portion.", "The method further includes providing a visual indication of the degree of focus for each of the at least two regions.", "Some embodiments provide for a method for visually indicating a degree of focus for a region of an image.", "The method can include detecting an image using at least one imaging sensor, providing a graphical representation of the image on a display, and applying an algorithm operating on one or more processors to determine a degree of focus for a region of the image.", "The method can further include providing a visual indication of the degree of focus on the display, wherein the visual indication includes a geometric figure that at least partially overlaps with the region on the graphical representation of the image.", "The method can set the visual indication to a first size corresponding to a first degree of focus.", "Furthermore, in response to an adjustment of focus and to a corresponding change in the determined degree of focus from the first degree of focus to a second degree of focus higher than the first degree of focus, the method can include changing the visual indication to a second size that is smaller than the first size.", "In some embodiments, the method can include determining a degree of focus for a second region of the image and providing a second visual indication of the degree of focus for the second region on the display, the second visual indication comprising a geometric figure.", "In some embodiments, the method can include setting the second visual indication to a first size corresponding to a first degree of focus for the second region.", "Moreover, in response to an adjustment of focus and to a corresponding change in the determined degree of focus for the second region from the first degree of focus for the second region to a second degree of focus for the second region higher than the first degree of focus, the method can include changing the second visual indication to a second size that is smaller than the first size.", "In some embodiments, an apparatus that assists in adjusting a focus of an image is provided.", "The apparatus can include at least one image sensor configured to detect an image and one or more processors configured to execute an algorithm to determine a degree of focus for a region of the image.", "The apparatus can include a display configured to show a graphical representation of the image and to show a visual indication of the degree of focus of the region, the visual indication comprising a geometric figure.", "In some embodiments, a size of the visual indication is correlated to the degree of focus of the region such that a first size of the visual indication corresponds to a first degree of focus of the region and a second size of the visual indication smaller than the first size corresponds to a second degree of focus of the region higher than the first degree of focus.", "In some embodiments, a method for assisting the adjusting of a focus of an image is provided.", "The method can include detecting an image, providing a graphical representation of the image, and receiving an indication of a selection of a first portion of the image.", "Based in part on the selection of the first portion of the image, the method can include applying an algorithm operating on one or more processors to determine a plurality of focus level values for the first portion of the image.", "The method can further include providing a magnified graphical representation of the first portion of the image in response to the selection of the first portion of the image, and providing a visual indication of the plurality of focus level values.", "In one embodiment, the method can include superimposing the magnified graphical representation and the visual indication on the graphical representation of the image.", "In one embodiment, the visual indication comprises at least one waveform.", "In certain embodiments, the graphical representation, the magnified graphical representation, and the visual indication are presented on a display of a motion picture camera.", "In some embodiments, the focus level values for the first portion of the image are indicated by varying a relief of the first portion of the image.", "In one embodiment, the selection of the first portion of the image is received through a user interface, such as a touch screen.", "The method can further include calculating a degree of focus corresponding to an average of at least two of the plurality of focus level values.", "In one embodiment, a size of the visual indication corresponds to the degree of focus.", "The method can include changing the size of the visual indication in response to a change in the degree of focus, e.g.", "the size of the visual indication can decrease in response to an increase in the degree of focus.", "In some embodiments, the visual indication is a circle.", "According to further aspects, the method can include superimposing the visual indication on the graphical representation of the image.", "The center of the visual indication can substantially coincide with the center of the first portion of the image when superimposed on the graphical representation of the image.", "In one embodiment, the color of the visual indication can correspond to the degree of focus.", "In such an embodiment, the method can include changing the color of the visual indication in response to a change in the degree of focus.", "For example, the color of the visual indication can be green when the degree of focus corresponds to a relatively high degree of focus, the color of the visual indication can be red when the degree of focus corresponds to a relatively low degree of focus, and the color of the visual indication can be yellow when the degree of focus corresponds to an intermediate degree of focus.", "As another example, the color of the visual indication can be green when the degree of focus is greater than an upper threshold, the color of the visual indication can be red when the degree of focus is less than a lower threshold, and the color of the visual indication can be yellow when the degree of focus is greater than or equal to the lower threshold and less than or equal to the upper threshold.", "According to further aspects, the method can include receiving a second indication of a second portion of an image, determining a plurality of focus level values for the second portion of the image, and providing a second magnified graphical representation of the second portion of the image in response to the selection of the second portion of the image.", "The method can further include providing a second visual indication of the plurality of focus level values for the second portion of the image.", "In one embodiment, the magnified graphical representation, the second magnified graphical representation, the visual indication, and the second visual indication are superimposed on the graphical representation of the image.", "In some embodiments, the algorithm to determine the degree of focus is applied before receiving the indication of the selection of the first portion of the image.", "In some embodiments, the algorithm is applied after receiving the indication of the selection of the first portion of the image.", "In certain embodiments, before receiving the indication of the selection of the portion of the image, the method includes applying the algorithm to determine the plurality of focus level values for one or more regions of the first portion of the image as well as for one or more regions that are not in the first portion of the image.", "The method can then include providing a visual indication of the plurality of focus level values for the one or more regions of the first portion and for the one or more regions that are not in the first portion.", "In certain implementations, the first portion of the image is described by a regular geometric pattern.", "Some embodiments provide for an apparatus that assists in adjusting a focus of an image.", "The apparatus can include a lens having a variable focal length, a focus adjustment that, in use, adjusts the focal length of the lens, and an image sensor that, in use, converts the visual data image from the lens into a digital representation of the image.", "The apparatus can further include an electronic display that, in use, shows a graphical representation of the image, an interface that, in use, receives a user selection of a first portion of the image, and one or more processors configured to process the digital representation of the image to determine a plurality of focus level values for one or more regions of the first portion.", "The electronic display can provide a magnified graphical representation of the first portion of the image in response to the user selection, and the electronic display can provide a visual indication of the plurality of focus level values.", "Some embodiments provide for a motion picture camera incorporating the apparatus.", "In further aspects, the interface can be a touch screen interface.", "The electronic display can, in use, display the visual indication and the magnified graphical representation superimposed on the graphical representation.", "The apparatus can further include one or more processors that, in use, calculate a degree of focus corresponding to an average of at least two of the plurality of focus level values for the one or more regions of the first portion of the image.", "In one embodiment, a size of the visual indication corresponds to the degree of focus.", "In certain embodiments, the apparatus updates the degree of focus calculation in real-time and changes the size of the visual indication in response to the updated degree of focus calculation.", "In some embodiments, the size of the visual indication decreases in response to an increase in the degree of focus." ], [ "PRIORITY INFORMATION This application is a continuation of U.S. application Ser.", "No.", "15/603,302, filed May 23, 2017, which is a continuation of U.S. application Ser.", "No.", "13/463,767, filed May 3, 2012, issued as U.S. Pat.", "No.", "9,690,168, which claims priority benefit from U.S. provisional application Nos.", "61/483,496 and 61/624,152, filed May 6, 2011 and Apr.", "13, 2012, respectively, and is a continuation-in-part of U.S. application Ser.", "No.", "12/479,546, filed Jun.", "5, 2009, issued as U.S. Pat.", "No.", "8,274,026, which is a divisional of U.S. application Ser.", "No.", "11/561,785, filed Nov. 20, 2006, issued as U.S. Pat.", "No.", "7,544,919.The entirety of each of the foregoing applications are hereby incorporated by reference.", "BACKGROUND The invention relates to providing focus information.", "There are two basic methods of focusing a camera or optical instrument.", "In an autofocus system, the camera sets the focus level with little or no user input.", "The camera collects data about the relative focus level of objects in the camera lens.", "It uses an algorithm to interpret that data and set an optimum focus level.", "However, this algorithm does not necessarily execute the photographer's intentions.", "Many autofocus algorithms prioritize objects that are close to the center of the frame or that are brightly lit.", "If the object of the photographer's interest is off-center or dimly lit, the autofocus algorithm may calibrate a focus level based on objects in which the photographer has no interest.", "Manual focus cameras require more effort from the user.", "But, they also give the photographer more control over the focus level.", "Because manual focus cameras are more responsive to the user's wishes and potentially more precise, professionals often use manual focus cameras.", "Whichever system a camera employs—autofocus or manual focus—the ability of the system to yield desirable results depends on the user's ability to confirm which objects are in or out of focus.", "In an autofocus system, if it is unclear which objects are in or out of focus, the user cannot confirm that the autofocus algorithm has identified the user's primary objects of interest and set the focus level accordingly.", "In a manual focus system, if a user cannot confirm which objects are in or out of focus, the user cannot confirm the precision of focus adjustments.", "Camera displays may be too small or imprecise to reliably convey to the user whether or not an object is in focus, or if out of focus, just how much out of focus.", "They do not often allow the user to distinguish between gradations in the focus level or balance the focus level between multiple objects in the viewfinder.", "SUMMARY An optical lens having a variable focal length is used to detect an image.", "The lens focuses the image on a sensor, and the sensor captures information corresponding to individual picture elements (pixels).", "A display shows the detected image.", "In order to assist a user to adjust the focus of the image, a waveform indicates a degree of focus.", "The waveform may be superimposed on the image, or may be displayed adjacent to the image.", "Alternatively, the waveform may be displayed on a separate screen.", "The waveform is updated in real-time, allowing the user to adjust the focus contemporaneously.", "The display of the degree of focus could be used, e.g., for still cameras and motion picture cameras.", "The optical sensor converts the image from the lens into a two-dimensional, digital array of pixels, with the array of pixels arranged in rows and columns.", "In one embodiment, a processor operates on a row of pixels to determine focus level data for a plurality of pixels in that row.", "The waveform may indicate the degree of focus through color variations, intensity variations, density variations, amplitude variations, or other visual indicia.", "A combination of different types of indicia may be used.", "The focus level data may be determined, for example, with an edge detection algorithm.", "In one embodiment, the focus level data is determined by comparing at least a portion of the digital array of pixels with a blurred rendition of the same portion of the array.", "In one embodiment, an image is detected using a two-dimensional array of optical sensors.", "The detected image is converted into a data structure that represents the detected image as a two-dimensional array of pixel values, where the pixel values are representative of an amount of light detected by the optical sensors.", "A blurred image is generated by combining a selected pixel value with a plurality of pixel values from the vicinity of the selected pixel value.", "The degree of focus is then determined by comparing the selected pixel value with a corresponding blurred image pixel value.", "A visual indication of the degree of focus is then provided.", "In one embodiment, the visual indication of the degree of focus may be overlaid on a representation of the detected image.", "In another embodiment, the visual indication of the degree of focus is adjacent to a representation of the detected image.", "Providing the visual indication of the degree of focus may comprise displaying a waveform corresponding to the degree of focus.", "A point on the waveform may correspond to an average degree of focus for a plurality of vertically aligned pixels.", "In another embodiment, a point on the waveform may correspond to an average degree of focus for a plurality of horizontally aligned pixels.", "In yet another embodiment, a point on the waveform may correspond to an average degree of focus for a plurality of pixels in a block.", "In a further embodiment, a point on the waveform corresponds to an average degree of focus for a plurality of non-adjacent pixels.", "In one embodiment, a method of providing feedback to allow focusing an image in real time comprises using a programmed algorithm to determine a degree of focus of a plurality of regions and providing a visual indication of the degree of focus of each region.", "The visual indication may take a variety of formats, such as, for example, a waveform, varying the relief of a region, or indication of focus by a geometric figure.", "The region may be, for example, a line or a regular geometric pattern.", "In one embodiment, the degree of focus of a region may indicated by varying the color of the region.", "In another embodiment, the degree of focus of a region may be indicated by varying the brightness of the region.", "The regions may be described by edge detection, and the degree of focus of each region may be indicated by varying, e.g., the brightness or color of an edge.", "According to further aspects, a method for assisting the adjusting of a focus of an image includes providing a graphical representation of a detected image.", "The method can also include receiving an indication of a user selection of a region of the image and providing a magnified graphical representation of the selected image region.", "The method may further include providing a graphical indication of a degree of focus for at least a portion of the selected image region.", "The graphical indication in some instances is visually correlated with the magnified graphical representation of the selected image region.", "According to further aspects, a method for assisting the adjusting of a focus of an image includes detecting an image and providing a graphical representation of the image.", "The method further includes receiving an indication of a user selection of a first portion of the image.", "The method can also include applying an algorithm operating on one or more processors to determine focus levels for one or more regions of the first portion of the image.", "In response to the user selection, the method can include providing a visual indication of the focus levels.", "In some additional embodiments, an apparatus assists in adjusting a focus of an image.", "The apparatus can include a lens having variable focal length.", "The lens produces a visual data image from light that enters the lens.", "The apparatus can also include a manual focus adjustment that adjusts the focal length of the lens and an optical sensor that converts the visual data image from the lens into a digital representation of the image.", "The apparatus may further include a display configured to show a graphical representation of the image.", "The apparatus can also include an interface configured to receive a user selection of a first portion of the image.", "In some instances, the apparatus further includes one or more processors configured to process the digital representation of the image to determine focus levels for one or more regions of the first portion.", "Additionally, the display can provide a visual indication of the focus levels.", "In some embodiments, a visual indication of a degree of focus of a region of an image is provided.", "In some embodiments, the visual indication of the degree of focus of the region or all or part of the image may be overlaid on a representation of the detected image.", "The visual indication can be overlaid on the representation of the detected image so that the center of the visual indication coincides with the center of the region of the image for which the degree of focus is visually indicated.", "The visual indication can be configured to change size, shape, and/or color in response to changes in the degree of focus.", "In some implementations, the visual indication decreases in size corresponding to an increase in the degree of focus of the region of the image.", "The visual indication can change color in response to changes in degrees of focus.", "The visual indication can change shape in response to changes in degrees of focus.", "The region of the image can be selected by a user.", "In some embodiments, a second visual indication can be overlaid on the representation of the detected image.", "The second visual indication can be configured to change color corresponding to changes in the degree of focus.", "The size of the second visual indication can correspond to the size of the region of the image for which the degree of focus is visually indicated.", "In some embodiments, multiple regions can be selected and corresponding visual indicators can be provided overlaid on the representation of the detected image.", "Although described with respect to particular example visual indications, other forms of visual indications are compatible with the techniques described herein.", "In some embodiments, a method for indicating a focus of a region of an image is provided.", "The method includes determining a degree of focus for a region of the image and providing a visual indication of the degree of focus.", "In response to a change in the degree of focus, the size of the visual indication can be changed, wherein the size of the visual indication is correlated to the degree of focus.", "In some embodiments, the size of the visual indication transitions from a first size to a second size based on a change from a first degree of focus to a second degree of focus.", "The transition can include adjusting the size of the visual indication to one or more intermediate sizes during the transition from the first size to the second size, the intermediate sizes being between the first size and the second size and corresponding to intermediate focus levels between the first degree of focus and the second degree of focus.", "In some embodiments, a degree of focus for a second region of the image is determined.", "A second visual indication of the degree of focus for the second region can be provided wherein the size of the second visual indication changes in response to a change in the degree of focus for the second region, wherein the size of the second visual indication is correlated to a current degree of focus.", "In some embodiments, an apparatus that assists in adjusting a focus of an image is provided.", "The apparatus can include an image sensor for detecting an image and one or more processors for determining a degree of focus for a region of the image.", "The apparatus can also include a display configured to show a graphical representation of the detected image and to show a visual indication of the degree of focus of the region, the visual indication having a size that is correlated to the degree of focus of the region.", "In some embodiments, a method for assisting the adjusting of a focus of an image is provided.", "The method can include detecting an image using at least one imaging sensor and providing a graphical representation of the image on a display.", "The method can further include receiving an indication of a user selection of a first portion of the displayed image and providing a magnified view of the first portion on the display.", "The method can include applying an algorithm operating on one or more processors to determine a degree of focus for at least two regions within the first portion.", "The method further includes providing a visual indication of the degree of focus for each of the at least two regions.", "Some embodiments provide for a method for visually indicating a degree of focus for a region of an image.", "The method can include detecting an image using at least one imaging sensor, providing a graphical representation of the image on a display, and applying an algorithm operating on one or more processors to determine a degree of focus for a region of the image.", "The method can further include providing a visual indication of the degree of focus on the display, wherein the visual indication includes a geometric figure that at least partially overlaps with the region on the graphical representation of the image.", "The method can set the visual indication to a first size corresponding to a first degree of focus.", "Furthermore, in response to an adjustment of focus and to a corresponding change in the determined degree of focus from the first degree of focus to a second degree of focus higher than the first degree of focus, the method can include changing the visual indication to a second size that is smaller than the first size.", "In some embodiments, the method can include determining a degree of focus for a second region of the image and providing a second visual indication of the degree of focus for the second region on the display, the second visual indication comprising a geometric figure.", "In some embodiments, the method can include setting the second visual indication to a first size corresponding to a first degree of focus for the second region.", "Moreover, in response to an adjustment of focus and to a corresponding change in the determined degree of focus for the second region from the first degree of focus for the second region to a second degree of focus for the second region higher than the first degree of focus, the method can include changing the second visual indication to a second size that is smaller than the first size.", "In some embodiments, an apparatus that assists in adjusting a focus of an image is provided.", "The apparatus can include at least one image sensor configured to detect an image and one or more processors configured to execute an algorithm to determine a degree of focus for a region of the image.", "The apparatus can include a display configured to show a graphical representation of the image and to show a visual indication of the degree of focus of the region, the visual indication comprising a geometric figure.", "In some embodiments, a size of the visual indication is correlated to the degree of focus of the region such that a first size of the visual indication corresponds to a first degree of focus of the region and a second size of the visual indication smaller than the first size corresponds to a second degree of focus of the region higher than the first degree of focus.", "In some embodiments, a method for assisting the adjusting of a focus of an image is provided.", "The method can include detecting an image, providing a graphical representation of the image, and receiving an indication of a selection of a first portion of the image.", "Based in part on the selection of the first portion of the image, the method can include applying an algorithm operating on one or more processors to determine a plurality of focus level values for the first portion of the image.", "The method can further include providing a magnified graphical representation of the first portion of the image in response to the selection of the first portion of the image, and providing a visual indication of the plurality of focus level values.", "In one embodiment, the method can include superimposing the magnified graphical representation and the visual indication on the graphical representation of the image.", "In one embodiment, the visual indication comprises at least one waveform.", "In certain embodiments, the graphical representation, the magnified graphical representation, and the visual indication are presented on a display of a motion picture camera.", "In some embodiments, the focus level values for the first portion of the image are indicated by varying a relief of the first portion of the image.", "In one embodiment, the selection of the first portion of the image is received through a user interface, such as a touch screen.", "The method can further include calculating a degree of focus corresponding to an average of at least two of the plurality of focus level values.", "In one embodiment, a size of the visual indication corresponds to the degree of focus.", "The method can include changing the size of the visual indication in response to a change in the degree of focus, e.g.", "the size of the visual indication can decrease in response to an increase in the degree of focus.", "In some embodiments, the visual indication is a circle.", "According to further aspects, the method can include superimposing the visual indication on the graphical representation of the image.", "The center of the visual indication can substantially coincide with the center of the first portion of the image when superimposed on the graphical representation of the image.", "In one embodiment, the color of the visual indication can correspond to the degree of focus.", "In such an embodiment, the method can include changing the color of the visual indication in response to a change in the degree of focus.", "For example, the color of the visual indication can be green when the degree of focus corresponds to a relatively high degree of focus, the color of the visual indication can be red when the degree of focus corresponds to a relatively low degree of focus, and the color of the visual indication can be yellow when the degree of focus corresponds to an intermediate degree of focus.", "As another example, the color of the visual indication can be green when the degree of focus is greater than an upper threshold, the color of the visual indication can be red when the degree of focus is less than a lower threshold, and the color of the visual indication can be yellow when the degree of focus is greater than or equal to the lower threshold and less than or equal to the upper threshold.", "According to further aspects, the method can include receiving a second indication of a second portion of an image, determining a plurality of focus level values for the second portion of the image, and providing a second magnified graphical representation of the second portion of the image in response to the selection of the second portion of the image.", "The method can further include providing a second visual indication of the plurality of focus level values for the second portion of the image.", "In one embodiment, the magnified graphical representation, the second magnified graphical representation, the visual indication, and the second visual indication are superimposed on the graphical representation of the image.", "In some embodiments, the algorithm to determine the degree of focus is applied before receiving the indication of the selection of the first portion of the image.", "In some embodiments, the algorithm is applied after receiving the indication of the selection of the first portion of the image.", "In certain embodiments, before receiving the indication of the selection of the portion of the image, the method includes applying the algorithm to determine the plurality of focus level values for one or more regions of the first portion of the image as well as for one or more regions that are not in the first portion of the image.", "The method can then include providing a visual indication of the plurality of focus level values for the one or more regions of the first portion and for the one or more regions that are not in the first portion.", "In certain implementations, the first portion of the image is described by a regular geometric pattern.", "Some embodiments provide for an apparatus that assists in adjusting a focus of an image.", "The apparatus can include a lens having a variable focal length, a focus adjustment that, in use, adjusts the focal length of the lens, and an image sensor that, in use, converts the visual data image from the lens into a digital representation of the image.", "The apparatus can further include an electronic display that, in use, shows a graphical representation of the image, an interface that, in use, receives a user selection of a first portion of the image, and one or more processors configured to process the digital representation of the image to determine a plurality of focus level values for one or more regions of the first portion.", "The electronic display can provide a magnified graphical representation of the first portion of the image in response to the user selection, and the electronic display can provide a visual indication of the plurality of focus level values.", "Some embodiments provide for a motion picture camera incorporating the apparatus.", "In further aspects, the interface can be a touch screen interface.", "The electronic display can, in use, display the visual indication and the magnified graphical representation superimposed on the graphical representation.", "The apparatus can further include one or more processors that, in use, calculate a degree of focus corresponding to an average of at least two of the plurality of focus level values for the one or more regions of the first portion of the image.", "In one embodiment, a size of the visual indication corresponds to the degree of focus.", "In certain embodiments, the apparatus updates the degree of focus calculation in real-time and changes the size of the visual indication in response to the updated degree of focus calculation.", "In some embodiments, the size of the visual indication decreases in response to an increase in the degree of focus.", "BRIEF DESCRIPTION OF THE DRAWINGS These and other features will now be described with reference to the drawings summarized below.", "These drawings and the associated description are provided to illustrate a preferred embodiment of the invention, and not to limit the scope of the invention.", "FIG.", "1 shows a horizontal line graph conveying focus level data.", "FIG.", "2 shows a vertical line graph conveying focus level data.", "FIG.", "3 shows a horizontal line graph conveying focus level data with three separate lines.", "FIG.", "4 shows a grid overlaid on an image, by which grid, focus level data may be calculated or displayed.", "FIG.", "5 shows highlights around objects, which highlights convey focus level data.", "FIG.", "6 shows a high-level diagram of the focus assist system.", "FIG.", "7 shows a horizontal line graph conveying focus level data from a horizontal scan line.", "FIG.", "8 shows a horizontal line graph conveying focus level data from a scan line, wherein the focus level data has been calculated using an edge detection algorithm.", "FIG.", "9 shows a vertical line graph conveying focus level data from a vertical scan line.", "FIG.", "10 shows horizontal and vertical line graphs conveying focus level data from horizontal and vertical scan lines, respectively.", "FIG.", "11 shows a horizontal line graph conveying focus level data from a sloped scan line.", "FIG.", "12 shows a horizontal line graph conveying focus level data averaged from three scan lines.", "FIG.", "13 shows a horizontal line graph conveying focus level data averaged from a scan line greater than one pixel wide.", "FIG.", "14 shows a horizontal line graph conveying focus level data with three separate lines, each of which lines corresponds to a different horizontal scan line.", "FIGS.", "15A-15C show an example display having focus assist capability integrated with a magnification function.", "FIGS.", "16A-16B show another example display having integrated focus assist and magnification functionality.", "FIGS.", "17A-B show an example display having integrated focus assist that includes an indicator that changes size according to a level of focus.", "FIG.", "18 shows an example display having integrated focus assist that includes a plurality of indicators that change size according to levels of focus at a plurality of points.", "FIG.", "19 shows a flow chart of an example method of indicating a level of focus on a display.", "DETAILED DESCRIPTION The following description of different implementations has been presented by way of example only, and should not be read in a limiting sense.", "The scope of the present invention is defined only by the claims.", "In one embodiment, a camera displays focus level data to a user.", "The focus level data may be superimposed on the primary viewfinder screen, or it may be displayed on a secondary screen.", "Various optical imaging systems—such as the motion picture camera or the photo camera—might generate and display focus level data.", "However, the invention is not limited to cameras.", "Any optical imaging system can display focus level information to the user.", "Examples include light microscopes, telescopes, or binoculars.", "Similarly, non-optical instruments that produce an image can also display focus level information to the user.", "An example is an electron microscope.", "Further, an algorithm can generate and display focus level data to the user for images or videos after they have been recorded.", "A wide variety of different display techniques convey focus level data to the user.", "For instance, FIG.", "1 shows a line graph 300 oriented below the image 302.Alternatively the camera or display might show the line graph superimposed on the image.", "The line graph 300 displays higher values 304 for objects in greater focus 306.It displays lower values 308 for less well focused objects 310.Thus, as focus levels change for objects, the values displayed on the line graph 300 will change in response.", "The x-axis 312 represents a baseline level of focus, below which no focus level data is displayed.", "The x-axis 312 threshold may be set according to a number of different criteria.", "It might reflect some absolute number-value related to the slope of the gradient—the gradient being calculated by an edge detection algorithm as explained below.", "Or, the threshold might be tied dynamically to an average focus level of the entire image.", "So, the threshold could be set to 150% or 200% of the average focus level.", "This mechanism could be used to eliminate low, “noise” values from the display or to display data only for those display objects considered to be in focus or relatively in focus.", "In one embodiment, the focus level data displayed on line graph 300 covers a continuous range of focus level values—or at least continuous in a discrete, digital sense, limited by pixels and sampling rate.", "Thus, a continuous range of focus levels can be displayed on line graph 300.This does not necessarily mean that the values on the line graph 300 correspond one for one to the focus level value at a given point on the image 302.The line graph 300 may be continuous, and yet represent an adjusted function of the raw focus level data that is better perceived by the user.", "In one embodiment, the values on the line graph 300 are discrete, i.e.", "the focus level values can cover a continuous range but the line graph 300 can display discrete values corresponding to focus level ranges.", "The number of focus level ranges can be two, three, four, five, or more than five ranges.", "As an example, the line graph can display a first value corresponding to a first focus level value that falls within a first focus level range, a second value corresponding to a second focus level value that falls within a second focus level range, and a third value corresponding to a third focus level value that falls within a third focus level range where the first, second, and third values are different from one another and the first, second, and third focus level ranges are different from one another.", "A single, horizontal line graph 300 like the one in FIG.", "1 might not accurately convey focus level information for objects oriented vertically in the image.", "Because the line graph displays only one value for each horizontal point, it might obscure different focus levels oriented vertically with respect to that point.", "FIG.", "2 shows a vertical line graph 400 display.", "It displays more accurate focus level information for vertically oriented objects, but might obscure different focus levels for horizontally oriented objects.", "Another display might combine vertical and horizontal line graphs.", "Such a display overcomes some of the disadvantages of either the horizontal or vertical displays alone.", "But, depending upon how the data is presented, it may require the user to glance at two different locations to obtain focus level information for what may be a fleeting image.", "FIG.", "3 shows another horizontal line graph.", "However, this horizontal line graph comprises several lines.", "Each line represents focus level information for a different area of the image 302.For example, one or more lines 3001 represent focus level information for the top of the image 302.One or more lines 3002 represent focus level information for the middle of the image 302.One or more lines 3003 represent focus level information for the bottom of the image 302.Where the focus level is very similar at the top, middle, and bottom of the image, the lines begin to overlap and intensify.", "Other embodiments do not use a graph display.", "For instance, FIG.", "4 shows a grid 712 superimposed on the image 302.The grid 712 itself need not be visible to the user.", "But, the grid regions 714 each indicate a focus level.", "One method of indicating focus level is a color tint on the region 714.So, a very well-focused region 714 might have a first color such as a red tint.", "A very poorly focused region 714 might have a second color such as a violet tint.", "Regions 714 with focus levels neither very well nor very poorly focused may carry a tint along the color spectrum, which correspond to their respective focus levels.", "Another method of indicating focus level within a grid region 714 is to vary the brightness level of each region 714.A very well focused region 714 might have a first, relatively high brightness.", "A very poorly focused region 714 might have a second, relatively low (dark) brightness.", "Regions 714 with focus levels in between may carry a level of brightness corresponding their respective focus levels.", "Other display embodiments highlight the objects themselves instead of using grids or graphs to display focus level data for a general area.", "In FIG.", "5, the most focused object 306 has a bright highlight 818 that traces the object's edge.", "The least focused objects 310 have very dim highlights 822.The brightness of the highlight varies with the focus level of the object.", "Alternatively, the display might draw a color tint around the edges of objects to indicate their respective focus levels.", "For instance, objects that are focused very well 306 would have a first color such as a red tint at their edge.", "Very poorly focused objects 310 have a second color such as a violet tint at their edge.", "Objects that are neither very well nor very poorly focused would carry a tint along their edge corresponding to their respective focus levels.", "Rather than merely highlighting around each object, one embodiment raises the relief of an entire object when it is in focus.", "Objects that are out of focus 310 appear either flat or at a negative relief.", "Focused objects 306 rise up from the image, while unfocused objects 310 recede.", "The relief of each object corresponds to its focus level.", "This implementation has the advantage that the user can concentrate on the objects in the viewfinder to glean focus level data.", "Because this embodiment is highly intuitive, the user does not need to interpret much display data to determine the relative focus levels of objects in the display.", "FIG.", "6 shows an embodiment of the architecture of a camera.", "The camera collects visual data 924 from the camera lens 926.The camera records the visual data 924 and displays a representation of the visual data 924 on the viewfinder 930.The camera also sends the visual data 924 to a processor 928.The processor uses an algorithm to compute focus level data 932 for the visual data 924.The processor sends that focus level data 932 to the viewfinder, where the user 934 sees it superimposed on the visual data 924.The viewfinder 930 shows focus level data 932 from the processor 928 and visual data 924 from the lens 926 contemporaneously.", "In an alternative embodiment (not shown), in an autofocus camera, the processor that accepts the visual data and computes the focus level data is also the processor that computes focus level data for the autofocus system.", "An autofocus system automatically generates focus level data to determine the proper focus level setting.", "In this embodiment, that data is reused.", "Not only does the camera use the focus level data to achieve an optimal focus setting, but the data is also sent to the user through the viewfinder.", "The user can then confirm that the autofocus system has identified and set the focus level for the object or objects in which the user is interested.", "The processor uses an algorithm to calculate the focus level data displayed to the user.", "In one embodiment, the processor blurs image data to create a comparison image.", "For instance, the processor might use a Gaussian or quick box blur approximation, or convolve the image.", "The blurred image differs from the original image primarily at the edges of focused objects 306.With focused objects 306, the blurring process washes out the sharp contrast between the edge of the object 306 and its surroundings.", "The blurring process creates less change at the edges of unfocused objects 310.The soft contrast between an unfocused object 310 and its surroundings remains a soft contrast in the blurred, comparison image.", "Because edges are typically composed of the pixels that change the most during the blurring process, it is possible to find the edges of focused objects.", "Several alternative algorithms exist to detect whether or not an image is in focus.", "Many of these are “edge detection” algorithms.", "Examples of edge detection algorithms can be found in Fundamentals of Digital Image Processing by Anil K. Jain, the entirety of which is incorporated here by reference.", "One algorithm uses gradient operators to detect edges.", "Gradient operators are masks, or simple matrices, used to generate a gradient map.", "Gradient operators, when convolved with pixels in an image, yield a gradient map in two orthogonal directions.", "Similarly, compass operators yield a gradient map in a selected number of directions that correspond to compass directions.", "Once the gradient has been calculated, an edge is identified by searching for those spots where the gradient exceeds some threshold.", "The level of focus, generally, corresponds to the severity of the gradient.", "Other edge detection algorithms apply a second-order derivative to the image.", "The derivative detects rates of change in pixel intensity across the image.", "Again, the algorithm usually convolves the image with an operator.", "Edges are identified by locations where the gradient exceeds some threshold, or more commonly, by searching for spots where the second derivative wave-form crosses zero.", "While zero crossings are useful to detect edges, they only return a binary value and therefore do not convey precise focus level data.", "Here again, the focus level generally corresponds to the severity of the gradient at objects' edges.", "The gradient measures changes in the intensity of adjacent pixels.", "The intensity may be measured according to one or more of several different elements of each pixel.", "The intensity may refer to the red, green, or blue content of a pixel or any combination thereof.", "In YCbCr systems, it may refer to the luma or chroma component of each pixel or a combination thereof.", "In HSV systems, it may refer to the hue, the saturation, or the brightness components of the pixel, or any combination thereof.", "Depending on the color space of processing and display systems, the processor may use whichever components of the pixels' value that obtain the optimal gradient map or optimal focus level data.", "One way of using an edge detection algorithm to derive focus level data for an entire image—rather than its edges only—is to use boundary extraction.", "By connecting edges, boundaries define the shape of an object.", "Assuming that an entire object is in focus if its edges are in focus, the camera can use boundary detection to determine the object's shape and impute the focus level at the object's edge to the rest of the shape.", "A contour following algorithm is a boundary extraction algorithm that uses a series of horizontal or vertical steps chosen by trial and error.", "The correct step is determined by whether the step arrives inside or outside a boundary.", "Another boundary extraction algorithm uses the computer science principle of dynamic programming.", "With dynamic programming the solution to a large problem is a function of the solutions to its sub-problems.", "In the boundary extraction context, that means that optimal sub-paths will lead to the optimal boundary.", "The focus level detection algorithm measures focus level for a selection of pixels.", "The number and location of the pixels for which the algorithm calculates focus level data are a function of the speed of computation, detail of focus level data, and type of focus data desired to be displayed to the user.", "In one embodiment, the focus level algorithm calculates focus level data for one or more “scan lines.” The simplest example of the scan line embodiment is depicted in FIG.", "7.In that figure, a single scan line 1144 extends horizontally across the image 302.The scan line 1144 need not be vertically centered.", "The user can adjust the position of the scan line 1144.The focus level algorithm calculates a focus level value for each pixel along the scan line 1144 and displays it as a point along line graph 300.In another embodiment, to save processing time, the focus level algorithm might measure no more than about 50% or no more than about 25% of the pixels, such as by measuring only every other pixel or only one of every several pixels on the scan line 1144.Line graph 300 shows how the focus level display corresponds to the focus level measured at each pixel along the scan line 1144.As the focus level measured at each pixel along the scan line 1144 changes, the focus level display shown by line graph 300 will change in response by decreasing and/or increasing portions of the line graph 300.In FIG.", "8, the scan line 1144 and display technique are identical to those of FIG.", "11.But, instead of a smooth waveform, the line graph 300 has spikes.", "This spiked waveform depicts the data produced by an edge detection algorithm.", "The focus level data is more accurate at the edges of objects.", "At the edges of bars that are focused 306, the graph 300 shows a high value.", "Likewise, at the edges of bars that are not focused 310, the graph 300 shows low values.", "As the focus changes from one object to another, the graph 300 will show changing values at the edges of bars corresponding to changes in focus level data.", "But, the graph 300 does not show high or low values for the middle parts of objects.", "In the middle parts of objects, the correspondence between high contrast—on which edge detection algorithms rely—and high focus, is less reliable.", "This is because the middle parts of objects are less likely to have high contrast values whether they are in focus or not.", "The scan line 1344 might be vertically oriented, as in FIG.", "9, rather than horizontally oriented.", "A vertical scan line 1344 gives better focus level data for a series of objects oriented vertically in the viewfinder.", "Like the horizontal chart for a horizontal scan line, a vertical chart 400 displays focus level data for a vertical scan line.", "Another, more detailed embodiment depicted in FIG.", "10 employs both vertical 1344 and horizontal 1144 scan lines and both vertical 400 and horizontal 300 graphs.", "The scan line need not run precisely horizontally (or vertically) across the image.", "The scan line 1144 might run at a slope, as in FIG.", "11.In FIG.", "12 the display again consists of a single-line graph 300.And, the algorithm again uses scan lines to identify the pixels for which it will calculate focus level data.", "But, instead of using only a single scan line, the algorithm averages data from multiple scan lines 1144, such as at least two, in some embodiments at least five, and in other embodiments at least 10 scan lines.", "Depending on the location of the scan lines and of objects in the image, this technique may improve the accuracy of the focus level display.", "The more scan lines 1144 the processor employs, the more focus level data it collects and the more accurate it will be.", "But, the more scan lines 1144 the processor employs, the more computations it must run and the slower it will generate focus level data.", "Again, the camera might use vertical scan lines 1344 instead of or along with horizontal scan lines 1144 for this or any scan-line technique.", "FIG.", "13 shows yet another embodiment based on the scan line.", "However, in this embodiment, the scan line 1144 is greater than a pixel in width.", "The scan-line width 1746 may be set to as many or as few pixels as desired.", "In fact, this is a variation on the multiple scan-line embodiment depicted in FIG.", "12.A scan line 1144 a number of pixels in width 1746 is the same as that same number of adjacent scan lines, each one pixel in width.", "For example, the average focus level of a scan line 1144 five pixels wide 1746 is identical to the average focus level of 5 scan lines 1144, each adjacent to the next.", "To limit power consumption or decrease computational time, the processor might calculate focus level data only for every other adjacent scan line 1144 or one of every several adjacent scan lines 1144.The processor need not generate an average focus level for multiple scan lines.", "FIG.", "14 shows a graph display with a graph line 3001-03 corresponding to each scan line 1144.Alternatively, each graph line might convey average focus level data from multiple scan lines as an aid to the user.", "In addition, the processor 928 might apply a secondary filtering algorithm to the focus level data from one or more scan lines.", "For instance, the processor 928 might apply an algorithm that zeroes all focus level values below a certain threshold.", "Such an algorithm might be used to eliminate noise from the display, to avoid distracting the user.", "The threshold may or may not be set at the same point as the baseline x-axis 312 in the display, depending on the desired height of the line graph 300 in the display.", "Indeed, the camera might allow the user to set the threshold.", "Like the x-axis 312 baseline, this algorithmic threshold might be set according to either an absolute value related to the slope of the gradient, as calculated by an edge detection algorithm.", "Or, it might be a function of the average level of focus of the image.", "For instance, the algorithm might eliminate focus level values for objects that have less than a threshold such as about 150% of the average focus level of the image.", "A secondary algorithm might also be used to smooth the focus level data, again to present a simplified, easily perceived waveform to the user.", "This technique might be useful with edge detection algorithms, which tend to produce spikes.", "In short, the scan line embodiments are not limited by any particular scan lines or choice of pixels within those scan lines.", "Rather, the scan lines might be implemented in any permutation that satisfies a desired balance between computational speed, detail of information, and method of display to the user.", "Scan lines are merely one method of applying a focus level detection algorithm.", "The algorithm might compute focus level information for the entire image, or for some alternative subset of that image.", "That alternative subset may be a geometric area.", "The geometric area might be defined by the user or it might be set by an algorithm, for example, to track a moving object in the viewfinder.", "The alternative subset might also be a pattern of pixels, designed as a representative sampling of the image, but at a lower level of detail and therefore requiring fewer computations.", "In order to display focus level data in the pattern of a grid, the algorithm calculates focus level data for at least a portion of each region within the grid.", "The algorithm might calculate focus level data for only a pixel within each region.", "The algorithm might calculate focus level data for the entire region and average the data to display an indication of the focus level.", "If the algorithm calculates enough focus level data—at least enough for a representative sampling of the image—it is possible to display to the user focus level information based on edges superimposed on the image.", "Because an edge-detection algorithm returns data that corresponds to the edges of each object, the display might use that data to highlight the edges of objects in the viewfinder in real time.", "This might be done by varying the brightness of the edges of objects or by drawing a color around objects, the shade or width of which would correspond to the degree of focus.", "Algorithms that generate reliable focus level data for entire objects enable other display techniques.", "One display varies the relief of an object according to its focus level.", "So, in focus objects would bulge out of the picture and become more prominent than unfocused objects.", "Similarly, another display renders objects in three dimensions when they are focused.", "The further out of focus the object becomes, the flatter it becomes in display.", "Additionally, in some instances the display allows a user to present detailed focus level information for select portions of the image scene.", "For example, some displays allow for magnification of certain image scene regions and adjust the presentation of the focus level data to accommodate the current view.", "FIGS.", "15A-15C show an example display 1500 having focus assist capability integrated with a magnification function.", "The display 1500 conveys focus level data from a scan line, wherein the focus level data has been calculated using an edge detection algorithm.", "Moreover the graph 1502 has spikes corresponding to the focus level data produced by the edge detection algorithm.", "Thus, like the graph 300 of FIG.", "8, at the edges of objects that are focused 1508, the graph 1500 shows a high value 1506.Likewise, at the edges of objects that are not focused 1510, the graph 1500 shows low values.", "Further, at the edges of bars that are focused at an intermediate level 1509, the graph 1500 shows intermediate values 1507.But, the graph 300 does not show high or low values for the middle parts of objects.", "In the middle parts of objects, the correspondence between high contrast—on which edge detection algorithms rely—and high focus, is less reliable.", "As discussed above, this is because the middle parts of objects are less likely to have high contrast values whether they are in focus or not.", "Generally, the display 1500 shows the focus level information in a manner that is visually correlated with corresponding image regions.", "For example, the illustrated display 1500 shows the graph 1502 oriented below the image 1504.Moreover, the waveform regions 1506, 1507, 1510 are lined up with the edges of the corresponding bars 1508, 1509, 1512.Alternatively, the display 1500 might show the graph 1500 superimposed on the image 1504 or may present the focus information according any of the other techniques described herein.", "For example, as discussed further below with respect to FIGS.", "16A-16B, in another instance the display 1500 visually associates the focus level information with regions of a grid that are overlaid on corresponding portions of the image 1504.The display 1500 is also responsive to user input to magnify a portion 1514 of the image 1504.FIG.", "15A shows the display 1500 in an un-magnified state, and thus the entire image 1504 is visible.", "FIG.", "15B, on the other hand, shows an example of the display 1500 in a magnified state.", "In the illustrated case, the user has selected the region 1514 corresponding to the upper left quadrant of the image for magnification.", "The camera may or may not actually display the dotted line delineating the magnified region 1514.While the representation of the region 1514 is magnified on the display 1500, the zoom level of the camera according to certain embodiments is adjusted independently.", "Thus, the camera includes a separate control to magnify the display 1500, and the zoom level of the lens does not change in response to user interaction with the separate magnification control.", "In one embodiment, the camera includes a touch screen interface allowing the user to adjust the magnification.", "For example, the user may double-tap the desired region 1514 for magnification.", "In another instance, the user increases or decreases the level of magnification using a multi-touch gesture, such as by spreading apart and pinching together his or her thumb and forefinger on the portion of the display corresponding to the desired image region.", "A wide variety of other touch screen control mechanisms are possible.", "Moreover, other types of interfaces can be used instead of or in addition to touch screens, including, but not limited to, joysticks, keypads, and the like.", "The display 1500 can allow the user to manipulate the display in a variety of ways.", "For example, in some cases, after achieving the desired magnification level the user manipulates the display 1500 to scroll to another portion of the image 1504.Referring to FIGS.", "15A-15B, for example, after magnifying the region 1514 (FIG.", "15B), the user can scroll to view another region of the magnified image.", "The user may do so using a swiping gesture where a touch screen interface is provided, or using a directional keypad in another configuration.", "Moreover, as shown, the display 1500 can update the focus level information depicted in the line graph 1502 to correspond to the newly displayed portion of the image 1504.The update can occur or at least appear to occur in substantially real-time.", "Additionally, while one magnification level is shown in FIG.", "15B, in certain instances the display 1500 allows for further zoom levels.", "FIG.", "15C shows such a case, where the user selects the region 1514 (FIG.", "15B) corresponding to the center of the image 1504 for further magnification.", "The transition to the desired magnification level is continuous in some cases, or there may alternatively be one or more discrete zoom levels (e.g., 1×, 2×, 4×, 8×, etc.).", "In some embodiments, the user may select any desired portion of the image scene for magnification.", "In other instances, the image scene areas selectable for magnification are predefined.", "For example, referring to FIG.", "15A, in one instance the user can only zoom in on one of the predefined image scene quadrants at a given time.", "Where the areas are pre-defined, the display 1500 may nonetheless provide more than one level of magnification.", "The display 1500 can provide enhanced focus information when in the magnified state, enabling higher precision focus control.", "Referring again to FIGS.", "15B-15C, the display 1500 dynamically updates the line graph 1502 to accommodate the change in magnification.", "In the magnified state, the display 1500 presents the focus information for the displayed objects with a higher degree of granularity.", "Thus, users can make relatively finer distinctions between gradations in the focus level than in the zoomed-out state, providing improved focus control.", "As another example, the image scene might include a large number of objects such that the objects may crowd together on the display.", "Thus, the corresponding portions of the graph 1502 may also bunch together, making it difficult to interpret the focus information.", "However, in such cases, the user can to drill-down on particular regions of the scene.", "Thus, the objects and corresponding focus level data in the magnified portion will appear relatively less crowded, making it easier to distinguish between focus levels for closely spaced objects.", "When focus assist information is combined with magnification capability, the system can calculate the enhanced focus assist information according to any of the algorithms provided herein, or according to some other appropriate algorithm.", "Moreover, the display 1500 can present the focus level data in a variety of ways.", "For example, the system can display one or more magnified regions with one or more visual indications for each magnified region, where the size, shape, and/or color of the visual indication conveys focus level data.", "In one alternative configuration, the display presents a magnified version of the selected image region, but continues to show the un-magnified version of the image as well.", "For example, the display presents the selected magnified portion of the image in a separate window that consumes only a portion of the display area.", "The separate window can be overlaid onto the un-magnified version of the image, or be displayed adjacent to it.", "Moreover, the display can provide a graph (or other focus level indication) associated with the magnified portion instead of, or in addition to, the graph for the un-magnified image.", "This technique enables detailed focus information for select image regions, but also in context with the entire scene.", "In other instances, the display provides detailed focus level information for the select region, but the selected image region itself is not magnified.", "In general, the display can present the focus assist information according to any of the techniques described herein including, without limitation, horizontal line graphs (FIGS.", "1, 3, 15A-B), vertical line graphs (FIG.", "2), with highlights around objects conveying focus information (FIG.", "5), combined horizontal and vertical graphs (FIG.", "10), multi-line graphs (FIGS.", "3 and 14), geometrical shapes having a size, color, and/or shape conveying focus information (FIGS.", "17A-B, 18).", "FIGS.", "16A-16B show an example display 1600 having integrated focus assist and zoom functionality, where a grid 1602 is overlaid on the image 1604 in a manner somewhat similar to FIG.", "4.As such, the grid 1602 may or may not be visible to the user, but the grid regions 1606 in one embodiment each indicate a focus level.", "As discussed above with respect to FIG.", "4, in one instance the system tints the individual regions 1060 according to the calculated level of focus.", "For example, poorly focused areas have a first color and well-focused areas have a second color.", "Regions 606 having intermediate focus levels may in turn carry a tint between the first and second colors along the color spectrum, and corresponding to the respective focus levels.", "FIG.", "17A shows an example display 1700 having focus assist capability that includes an indicator 1705 that changes size, shape, and/or color corresponding to a level of focus.", "The display 1700 can visually correlate the indicator 1705 with the level of focus for an image.", "For instance, the indicator 1705 superimposed over an image on the display 1700 can provide visual feedback to a user.", "The user can use the visual feedback to confirm that an auto-focus system is satisfactorily focused or to aid in the process of manually focusing an image.", "Superimposing the indicator 1705 over an image on the display 1700 has the advantage that the user can concentrate on the objects in the viewfinder to glean focus level data.", "This can be highly intuitive in that the user can easily interpret the display 1700 to determine the relative focus levels of desired portions of the displayed image, such as portions including an object 1710 in the display 1700.The display 1700 conveys focus level data at least in part through indicator 1705 wherein the focus level data has been calculated using any of the algorithms provided herein, or according to some other appropriate algorithm.", "For example, the focus level algorithm can include edge detection algorithms such as those using gradient operators or second-order derivatives, boundary extraction using edge detection algorithms, blurred image comparison using a Gaussian or quick box blur approximation, or any combination of these.", "In some embodiments, the focus level algorithm calculates the focus level for a subset of an entire image.", "The subset can be defined by a geometric area, a pattern of pixels, a scan line, multiple scan lines, or any combination of these.", "In some embodiments, an apparatus having display 1700 is configured to provide a way for the user to define a focus region.", "The display 1700 can be responsive to user input to select a focus region.", "In some embodiments, the display 1700 can include a touch screen interface allowing the user to select the focus region.", "The user can touch a portion of the image to select the region or can use other gestures or methods to define, zoom in on, or zoom out on, a region.", "Other types of interfaces can be used instead of or in addition to touch screens, including, but not limited to, joysticks, keypads, and the like.", "The focus region can be manipulated using methods similar to the manipulation of a magnified image as described herein with reference to FIGS.", "15A-C.", "The size of indicator 1705 can change corresponding to a change in the level of focus of a focus region.", "In some embodiments, the indicator 1705 can be a shape that decreases in size as the level of focus increases.", "For example, the indicator 1705 can be a circle that has a predefined radius when an object is out of focus, indicated by the solid circle in FIG.", "17A.", "As the level of focus increases, the radius of the circle can decrease, indicated by the dotted circles in FIG.", "17A.", "The visual effect of the indicator 1705 changing size can provide intuitive feedback to the user such that the user can relatively quickly surmise the level of focus in the focus region.", "In some embodiments, the indicator 1705 can have a maximum and minimum size such that when the level of focus reaches a certain level the indicator 1705 no longer responds to changes in the level of focus.", "The minimum size can correspond to a maximum level of focus or to some other threshold level of focus.", "In some embodiments, the size of the indicator 1705 increases with increasing level of focus.", "The change in size of the indicator 1705 can be continuous or substantially continuous, such that the size gradually changes as a function of the level of focus, or can be discrete, such that changes in size are in discrete increments, where a transition to a particular increment indicates that the current level of focus has passed corresponding threshold.", "In some embodiments, changes from one size to the next are discrete, but are close enough to one another to appear continuous to the human eye.", "The color of indicator 1705 can change in a fashion similar to the size.", "In some embodiments, the color of indicator 1705 changes from red to green to indicate a change from a low level of focus to a high level of focus.", "The change in color can be correlated with the size of indicator 1705.For example, the indicator 1705 can be a square that decreases in size and changes color from red to green as the level of focus increases.", "Similar to the change in size, the change in color can be a smooth transition along a spectrum of colors, or can be in discrete steps indicating that the current focus level has passed corresponding thresholds.", "For example, the color can be red when the level of focus is less than a defined lower threshold, and green when it is above a defined higher threshold.", "If there is a gap between the lower threshold and higher threshold, the indicator 1705 can be a third color, such as yellow.", "The colors can be different from those described above and may be able to be set by the user.", "The shape of indicator 1705 can change with the level of focus.", "The shape of the indicator 1705 can include, for example, polygons (e.g., squares, rectangles, triangles, etc.", "), curved geometric shapes (e.g., circles, ovals, ellipses, etc.", "), irregular shapes, cross-hairs, a reticle, an asterisk, parallel lines, perpendicular lines, multiple lines, or any combination of these.", "For example, the indicator 1705 can be an irregular shape that corresponds to the focus region having a low level of focus.", "As the level of focus increases the irregular shape can transform into a regular shape, such as a circle, indicating that the focus region has reached a predefined level of focus.", "As another example, the indicator 1705 can be the shape of a cross when the focus region has a low level of focus and change into a square when the focus region has a high level of focus.", "Similar to the size and color of the indicator 1705, the shape can change can be substantially continuous or discrete.", "The size, shape, and/or color of indicator 1705 can change in any combination as described herein to convey to the user a level of focus in such a way as to provide feedback that is intuitive and makes it relatively easy to quickly ascertain focus levels.", "The display 1700 can include a focus region(s) indicator 1715.The focus region indicator 1715 can be a visual feature on the display 1700 that marks the region(s) for which focus level information is being displayed.", "The focus region indicator 1715 can be one or more lines, a shape correlated with the size of the focus region, or some other visual feature capable of indicating a focus region.", "The focus region(s) indicator 1715 can be configured to be stationary relative to the display 1700 or to follow the selected region of interest as the object 1710 moves and/or the camera moves.", "As shown, the indicator 1715 can be centered, or substantially centered, on the focus region(s).", "In another embodiment, an arrow or other indicator points to or otherwise identifies the current focus region(s).", "The display 1700 can include visual features configured to aid the user in composing an image.", "In some embodiments, a marker 1720 can indicate the center of the image.", "The marker 1720 can assist the user in identifying where to line up a desired object, such as object 1710.Other visual features can be used such as, for example, a grid pattern, vertical lines, horizontal lines, diagonal lines, geometric shapes, or any combination of these.", "FIG.", "17B shows the display 1700 as described above with reference to FIG.", "17A where the display includes a focus region and level indicator 1725 that indicates a focus region and a level of focus.", "The focus region and level indicator 1725 can be configured to have a fixed size and shape that corresponds to a defined focus region.", "The focus region can have a different size and shape from the focus region and level indicator 1725.In some embodiments, the focus region and level indicator 1725 is a rectangle that is centered on the focus region, as indicated by focus region indicator 1715.In some embodiments, the focus region indicator 1715 is not included.", "The focus region and level indicator 1725 can change color corresponding with a level of focus in the focus region.", "As described above, the color can change according the focus levels in discrete steps or in a substantially smooth fashion.", "In some embodiments, the indicator 1705 has a fixed color and the focus region and level indicator 1725 changes color.", "In some embodiments, both the indicator 1705 and the focus region and level indicator 1725 change color.", "The colors of the indicators 1705, 1725 can be correlated.", "As an example, the user may desire to capture an image of an object 1710, but to only focus on a particular portion of the object.", "The display can visually correlate indicator 1705 with the focus region by centering the indicator 1705, which is a circle, on that region.", "The display can also display focus region and level indicator 1725 to indicate the size and shape of the focus region to the user.", "As the region becomes more focused, the radius of indicator 1705 gets smaller and the color of focus region and/or level indicator 1725 changes.", "Upon reaching a threshold level of focus, the indicator 1705 reaches a minimum size and the focus region and level indicator 1725 becomes a predefined color, such as green.", "The user can then quickly surmise that the focus region is focused.", "For instance, even though the indicator 1705 may be relatively small at a high focus level, the focus region and level indicator 1725 provides additional confirmation that the region is in focus.", "In some embodiments, the size of indicator 1705 changes in discrete steps corresponding to different focus levels.", "For example, the indicator 1705 can have a first size corresponding to a first focus level, a second size corresponding to a second focus level, and a third size corresponding to a third focus level where the first, second, and third sizes are configured to be distinguishably different when displayed.", "Some embodiments provide for a different number of discrete sizes corresponding to defined focus levels including, without limitation, two discrete sizes, four discrete sizes, five discrete sizes, and so on.", "FIG.", "18 shows an example display 1700 having integrated focus assist that includes a plurality of indicators 1705a-d that change size, shape, and/or color corresponding to levels of focus at a plurality of focus regions.", "The indicators 1705a-d can be correlated with the focus regions such that the position of the indicators 1705a-d on the display 1700 can correspond to their focus region.", "The indicators 1705a-d can change size, shape, and/or color as described more fully with reference to indicator 1705 in FIG.", "17A.", "The indicators 1705a-d can be independent from one another, individually indicating a level of focus of their corresponding focus region.", "The size, shape, and/or color of indicators 1705a-d can be different from one another or uniform across the display.", "The plurality of focus regions can be automatically selected, manually selected by a user using suitable techniques as described herein, and/or combining user input with automatic region selection.", "In some embodiments, the plurality of regions correspond to regions selected for magnification, as described more fully with reference to FIGS.", "15A-C and 16A-B.", "The plurality of regions can be magnified and indicators 1705 and/or focus region and level indicator 1725 can be included when the plurality of regions are displayed.", "FIG.", "19 shows a flow chart of an example method of indicating a level of focus on a display.", "For ease of description, the method will be described as being performed by the display.", "However, the method can be performed by the display, a camera, an apparatus attached to a display, one or more processors coupled to a display, a computer, a smartphone, or the like.", "In block 1905, the display correlates an indicator with a focus region.", "The focus region can be selected by the user, automatically, or some combination of these.", "Correlating an indicator with a focus region can include determining the center of the focus region and the center of the indicator and aligning these two centers.", "One or more focus regions can be defined and the display can repeat this step for each focus region.", "In some embodiments, the one or more focus regions correspond to magnified regions as described herein with reference to FIGS.", "15A-C and 16A-B.", "Selecting a focus region can include designating a region to magnify on the display.", "In block 1910, the display can show the indicator having an initial size, shape, and/or color.", "The initial characteristics of the indicator can reflect the initial level of focus in the region of interest.", "The level of focus can be determined using any of the algorithms provided herein, or according to some other appropriate algorithm.", "The display can correlate the level of focus with a size, shape, and/or color of the indicator.", "For example, the display can show a red circle with a relatively large radius corresponding to a focus region that is initially out of focus.", "As another example, the display can show a relatively small green square corresponding to a focus region that is initially in focus.", "This step can be repeated by the display for each focus region defined.", "In block 1915, the display can alter the size, shape, and/or color of the indicator corresponding to changes in the level of focus.", "In some embodiments, if the user manually changes the focus of the apparatus, the display determines the new focus level using an appropriate algorithm.", "In some embodiments, the focus is changed automatically rather than manually.", "If the level of focus changes in a focus region, the corresponding indicator can change in size, shape, and/or color.", "For example, if the level of focus increases the indicator can decrease in size.", "As another example, if the level of focus increases, the indicator can decrease in size and change color.", "As another example, if the level of focus increases the indicator can change both shape and color.", "As described above, the size, shape, and/or color can change substantially continuously or discretely in response to changes in focus levels.", "This step can be repeated by the display for each focus region defined.", "Conclusion It should be understood that the embodiments described herein may be implemented in a variety of ways.", "Other embodiments that are apparent to those of ordinary skill in the art, including embodiments which do not provide all of the benefits and features set forth herein, are also within the scope of this invention.", "For example, the camera could interface with a physically separate image processing device, such as a computer, or the image processing capabilities could be implemented within the camera.", "Further, algorithms may be implemented in a variety of ways, such as in hardware, software, or a combination of hardware and software.", "While some of the embodiments described herein provide specific details for implementation, the scope of the disclosure is intended to be broad and not limited to the specific embodiments described.", "Accordingly, details described in the specification should not be construed as limitations of the claimed invention.", "Rather, the scope of the claims should be ascertained from the language of the claims." ] ]
Patent_15872560
[ [ "METHOD FOR DETERMINING WHETHER AN INDIVIDUAL LEAVES A PRESCRIBED VIRTUAL PERIMETER", "A method and system that allows healthcare providers, hospitals, skilled nursing facilities and other persons to monitor disabled, elderly or other high-risk individuals to prevent or reduce falls and/or mitigate the impact of a fall by delivering automated notification of “at risk” behavior and falls by such an individual being monitored where assistance is required." ], [ "1.A system for detecting when a monitored individual or any part of the monitored individual has crossed outside of a designated electronic perimeter, the system comprising: one or more 3D camera, motion and sound sensors within a room occupied by a specific individual to be monitored, the one or more 3D camera, motion and sound sensors configured to: recognize one or more biometric identifiers of the specific individual; and electronically forward a continuous video feed to a computerized virtual safety rail monitoring system; wherein the computerized virtual safety rail monitoring system is configured to: electronically designate virtual safety rails defining a designated electronic perimeter within an area of the room; and detect whether the specific individual or any part of the specific individual has crossed over the designated electronic perimeter based on 3D information from the continuous video feed received from the one or more 3D camera, motion and sound sensors; and a centralized monitoring station configured to receive and display the continuous video feed.", "2.The system of claim 1, wherein, upon detecting that the specific individual or any part of the specific individual has crossed over the designated electronic perimeter, the computerized virtual safety rail monitoring system is configured to send an electronic alert to a computerized communication system.", "3.The system of claim 1, wherein upon detecting that the specific individual or any part of the specific individual has crossed over the designated electronic perimeter, the computerized virtual safety rail monitoring system is configured to send an electronic alert to a computerized communication system if the specific individual is alone, and the electronic alert is not sent if another individual is also detected at a time the designated electronic perimeter is crossed.", "4.The system of claim 1, wherein the 3D camera, motion and sound sensors are configured to continue sending the video feed to the computerized virtual safety rail monitoring system after it is detected that the specific individual or a part of the specific individual has crossed outside of the designated electronic perimeter.", "5.The system of claim 2, wherein the centralized monitoring station receives the continuous video feed from the computerized virtual safety rail monitoring system.", "6.The system of claim 5, wherein the centralized monitoring station aggregates continuous video feeds for multiple individuals to be monitored.", "7.The system of claim 6, wherein the centralized monitoring station comprises a primary monitoring display.", "8.The system of claim 7, wherein the centralized monitoring station displays the video feeds for each of the multiple individuals to be monitored on the primary monitoring display.", "9.The system of claim 7, wherein the centralized monitoring station is configured to receive an alert from the computerized virtual safety rail monitoring system, the computerized communication system, or both, upon detection that the specific individual or any part of the specific individual has crossed over the designated electronic perimeter.", "10.The system of claim 9, wherein upon receipt of an alert, the centralized monitoring station is configured to present an audible alert or a visual alert.", "11.The system of claim 7, wherein the centralized monitoring station is configured to receive an alert from the computerized monitoring system, the computerized communication system, or both, upon detection that the specific individual or any part of the specific individual has crossed over the designated electronic perimeter and has failed to return within the designated electronic perimeter within a predetermined period of time.", "12.The system of claim 9, wherein upon receipt of an alert, the centralized monitoring station is configured to present an audible alert or a visual alert.", "13.The system of claim 1, wherein electronically calibrating virtual safety rails comprises receiving placement information for the virtual safety rails.", "14.The system of claim 13, wherein electronically calibrating virtual safety rails comprises allowing a user to draw the virtual safety rails over an image or video from the one or more 3D camera, motion and sound sensors.", "15.A system for detecting when a monitored individual or any part of the monitored individual has crossed outside of a designated electronic perimeter, the system comprising: a computerized virtual safety rail monitoring system configured to: electronically receive a continuous video feed of a room occupied by a specific individual to be monitored; electronically recognize one or more biometric identifiers of the specific individual; electronically calibrate virtual safety rails defining a designated electronic perimeter within an area of the room; and detect whether the specific individual or any part of the specific individual has crossed over the designated electronic perimeter based on 3D information from the continuous video feed received from the one or more 3D camera, motion and sound sensors; and a centralized monitoring station configured to receive and display the continuous video feed.", "16.The system of claim 15, wherein, upon detecting the specific individual or any part of the specific individual has crossed over the designated electronic perimeter, the computerized virtual safety rail monitoring system is configured to send an alert to the centralized monitoring station, a computerized communication system, or both.", "17.The system of claim 16, wherein upon receipt of an alert, the centralized monitoring station is configured to present an audible alert or a visual alert.", "18.The system of claim 17, wherein upon receipt of an alert, the centralized monitoring station is configured to move the display of the continuous video feed for which an alert was received from a primary monitoring display to an alert display.", "19.The system of claim 16, wherein upon receiving an alert, the computerized communication system is configured to send an electronic notification message of the detected crossing of the designated electronic perimeter to the specific individual, a caregiver, or a designated person.", "20.A system for detecting when a monitored individual or any part of the monitored individual has crossed outside of a designated electronic perimeter, the system comprising: a computerized virtual safety rail monitoring system configured to: electronically receive a continuous video feed of a room occupied by a specific individual to be monitored; electronically recognize one or more biometric identifiers of the specific individual; electronically calibrate virtual safety rails defining a designated electronic perimeter within an area of the room; and detect whether the specific individual or any part of the specific individual has crossed over the designated electronic perimeter based on 3D information from the continuous video feed received from the one or more 3D camera, motion and sound sensors; a centralized monitoring station configured to receive and display the continuous video feed; and a computerized communication system configured to receive an alert from the computerized virtual safety rail monitoring system upon detection that the specific individual or any part of the specific individual has crossed over the designated electronic perimeter, and notify the specific individual, a caregiver, or a designated person." ], [ "<SOH> 2.BACKGROUND <EOH>According to recent studies, falls are a leading cause of death among people over the age of 65 years and 10% of the fatal falls for patients over 65 years of age occur in a hospital setting.", "For the general population, studies estimate that patient falls occur in 1.9 to 3% of all acute care hospitalizations.", "Of these hospital-based falls, approximately 30% will result in a serious injury with the cost to care for these injuries estimated to reach $54.9 billion per year by 2020.Current technologies that exist to assist in the prevention of falls are limited in their capabilities.", "These include pressure pads on the bed that trigger an alert when no pressure is detected on the pad, pressure pads on the floor and light beams that create a perimeter with alarms going off upon interruption of the beam.", "The pressure pads are ineffective as they do not prevent the fall but rather alert after the fact when it is too late.", "Additionally they are prone to false positive alerts.", "The light beams are also prone to false alerts when the patient or visitor simply reaches through it or the caregiver breaks the beam while delivering medication, food, drink or conducting a procedure on the patient." ], [ "<SOH> SUMMARY OF THE DISCLOSURE <EOH>The present disclosure is directed to addressing these above-described shortcomings with current technology.", "Generally disclosed is a novel method and system that allows healthcare providers, hospitals, skilled nursing facilities and other persons to monitor disabled, elderly or other high-risk individuals and utilize the described technology to prevent or reduce falls and/or mitigate the impact of a fall by delivering automated notification of “at risk” behavior and falls by such an individual being monitored where assistance is required.", "The following non-limiting definitions are provided as aid in understanding the disclosed novel method and system: 3D Camera, Motion An electronic device that contains one or more cameras capable of and Sound Sensor identifying individual objects, people and motion regardless of lighting conditions as well as one or more microphones to detect audio.", "The cameras can utilize technologies including but not limited to color RGB, CMOS sensors, infrared projectors and RF-modulated light.", "They may also contain microprocessors and image sensors to detect and process information both sent out and received by the various cameras.", "The electronic device calculates if there has been a change in location of the person or object of interest over a period of time.", "As a non- limiting example, a person's right knee can be at time T1 located at coordinates (x1, y1, z1) in a picture frame taken by the camera.", "At time T2 the right knee is capture by the picture frame taken by the camera at coordinates (x2, y2, z2).", "Based on this information, motion, speed and direction can be derived utilizing the elapsed time and comparing the two 3D coordinates over the elapsed time, As opposed to conventional motion sensors, which use captured motion to control a camera, the 3D Motion and Sound Sensor used with the method and system, uses the camera in order to compute the motion.", "The camera/sensors are preferably continuously on at all times during while the monitoring is occurring, regardless of whether the person or object of interest is moving or not.", "The 3D Camera, Motion and Sound sensor can additionally be programmed to lock on a person and can send back to the computerized monitoring system the 3D coordinates of the joints in the person's body and a skeletal outline of the person.", "As a non- limiting example, a person's right arm can be at time TI located at coordinates (x1, y1, z1) in a picture frame taken by the camera.", "At time T2 the right arm is captured by the picture frame taken by the camera at coordinates (x2, y2, z2).", "Based on this information, motion, speed and direction can be derived utilizing the elapsed time and comparing the two 3D coordinates over the elapsed time.", "The camera preferably views the entire bed or a large portion of the bed or other area that the patient is resting at (i.e.", "chair, couch, etc.)", "simply by its placement in a manner sufficient for the monitored area to be visible to the camera.", "Thus, the camera does not require any triggering event to cause the camera to begin recording video and/or 3D depth data or transmitting video and/or 3D depth data to the other components of the system for analysis.", "As the video camera is recording or otherwise transmitting video and/or 3D depth data to the other system components at all times during monitoring, the electronic device is able to immediately track, capture and/or record the monitored individual's movements at all times within the room or monitored area and will be able to provide information as to whether and when the individual begins to move or begins to get up to move.", "Preferably the 3D Camera, Motion and Sound Sensor records, captures and/or streams video and/or 3D depth data.", "As video is technically made up of individual picture frames (i.e.", "30 frames per second of video), the above reference to picture frames is referring to frames of video.", "Depth sensitivity can come into play with skeletal tracking in order to minimize false alarms, as objects behind and in front of the patient can be effectively ignored.", "The preferred use of depth as a factor also differentiates the current monitoring system from motion/object detection systems that rely on 2D images.", "The 3D Motion and Sound Sensor is located within the room of the patient being monitored and potentially just outside of the patient's room.", "It is connected to the computerized communication and computerized monitoring systems via a data connection (TCP/IP or comparable technology).", "Computerized Virtual A computer system specifically designed and programmed to create Safety Rail Monitoring virtual safety rails around a specific object such as a hospital bed and System which monitors activity based on information received from the 3D Camera, Motion and Sound sensor(s).", "The computerized monitoring system will preferably be located within the patient's room and can be connected to the centralized monitoring station at the facility but can also be located at any physical location so long as a data connection (TCP/IP or comparable technology) exists between the computerized monitoring system, the computerized communication system, centralized monitoring station and/or 3D motion and sound sensor.", "The computerized virtual safety rail monitoring system preferably makes its determinations based on the data received by the 3D Camera, Motion and Sound sensor(s).", "Computerized A computer system specifically designed and programmed to facilitate Communication System communication between the monitored patient and computerized monitoring system in the event the virtual safety rails are crossed.", "This system may include but is not limited to amplified speakers, microphones, lights, monitors, computer terminals, mobile phones and or other technologies to allow for the electronic communication to take place.", "The computerized communication system will preferably be located within the patients room being monitored but certain components of the system are mobile by their nature (i.e.", "mobile phones, pagers, computers) and can also be located at any location so long as a data connection (TCP/IP or comparable technology) exists between the computerized monitoring system, the computerized communication system, centralized monitoring station and 3D Camera, Motion and Sound sensor.", "System Database A computer database that stores records of all alerts generated, notifications, confirmation requests, responses, and reconfirmation requests and any other desired information concerning a triggering event or lack of triggering event(s).", "Centralized Monitoring A computer display connected to the centralized monitoring station, Primary Display showing video and audio of all patient rooms connected to the centralized monitoring station.", "Centralized Monitoring A computer display connected to the centralized monitoring station, Alert Display showing video and audio of any patient room where an individual is deemed to have crossed a virtual safety rail at the moment such determination is made.", "Caregiver A relative, friend, individual, company or facility whose purpose is to provide assistance in daily living activities for individuals who are disabled, elderly or otherwise in need of assistance." ], [ "This application is a continuation of U.S. application Ser.", "No.", "15/279,054, filed Sep. 28, 2016, which is a continuation of U.S. application Ser.", "No.", "14/728,762, filed Jun.", "2, 2015, which is a continuation-in-part of U.S. application Ser.", "No.", "14/084,588, filed Nov. 19, 2013, which is a continuation-in-part of U.S. application Ser.", "No.", "13/543,816, filed Jul.", "7, 2012, which claimed priority to and the benefit of U.S.", "Application Ser.", "No.", "61/507,088, filed Jul.", "12, 2011.U.S.", "application Ser.", "No.", "14/728,762 also claims priority to and the benefit of U.S.", "Application Ser.", "No.", "61/798,964, filed Mar.", "15, 2013.All of the above applications are hereby incorporated by reference in their entireties.", "1.FIELD OF THE DISCLOSURE The present disclosure is generally directed to patient monitoring systems and particularly to a system and method for monitoring patients in a manner which prevents or reduces patient falls.", "2.BACKGROUND According to recent studies, falls are a leading cause of death among people over the age of 65 years and 10% of the fatal falls for patients over 65 years of age occur in a hospital setting.", "For the general population, studies estimate that patient falls occur in 1.9 to 3% of all acute care hospitalizations.", "Of these hospital-based falls, approximately 30% will result in a serious injury with the cost to care for these injuries estimated to reach $54.9 billion per year by 2020.Current technologies that exist to assist in the prevention of falls are limited in their capabilities.", "These include pressure pads on the bed that trigger an alert when no pressure is detected on the pad, pressure pads on the floor and light beams that create a perimeter with alarms going off upon interruption of the beam.", "The pressure pads are ineffective as they do not prevent the fall but rather alert after the fact when it is too late.", "Additionally they are prone to false positive alerts.", "The light beams are also prone to false alerts when the patient or visitor simply reaches through it or the caregiver breaks the beam while delivering medication, food, drink or conducting a procedure on the patient.", "SUMMARY OF THE DISCLOSURE The present disclosure is directed to addressing these above-described shortcomings with current technology.", "Generally disclosed is a novel method and system that allows healthcare providers, hospitals, skilled nursing facilities and other persons to monitor disabled, elderly or other high-risk individuals and utilize the described technology to prevent or reduce falls and/or mitigate the impact of a fall by delivering automated notification of “at risk” behavior and falls by such an individual being monitored where assistance is required.", "The following non-limiting definitions are provided as aid in understanding the disclosed novel method and system: 3D Camera, Motion An electronic device that contains one or more cameras capable of and Sound Sensor identifying individual objects, people and motion regardless of lighting conditions as well as one or more microphones to detect audio.", "The cameras can utilize technologies including but not limited to color RGB, CMOS sensors, infrared projectors and RF-modulated light.", "They may also contain microprocessors and image sensors to detect and process information both sent out and received by the various cameras.", "The electronic device calculates if there has been a change in location of the person or object of interest over a period of time.", "As a non- limiting example, a person's right knee can be at time T1 located at coordinates (x1, y1, z1) in a picture frame taken by the camera.", "At time T2 the right knee is capture by the picture frame taken by the camera at coordinates (x2, y2, z2).", "Based on this information, motion, speed and direction can be derived utilizing the elapsed time and comparing the two 3D coordinates over the elapsed time, As opposed to conventional motion sensors, which use captured motion to control a camera, the 3D Motion and Sound Sensor used with the method and system, uses the camera in order to compute the motion.", "The camera/sensors are preferably continuously on at all times during while the monitoring is occurring, regardless of whether the person or object of interest is moving or not.", "The 3D Camera, Motion and Sound sensor can additionally be programmed to lock on a person and can send back to the computerized monitoring system the 3D coordinates of the joints in the person's body and a skeletal outline of the person.", "As a non- limiting example, a person's right arm can be at time TI located at coordinates (x1, y1, z1) in a picture frame taken by the camera.", "At time T2 the right arm is captured by the picture frame taken by the camera at coordinates (x2, y2, z2).", "Based on this information, motion, speed and direction can be derived utilizing the elapsed time and comparing the two 3D coordinates over the elapsed time.", "The camera preferably views the entire bed or a large portion of the bed or other area that the patient is resting at (i.e.", "chair, couch, etc.)", "simply by its placement in a manner sufficient for the monitored area to be visible to the camera.", "Thus, the camera does not require any triggering event to cause the camera to begin recording video and/or 3D depth data or transmitting video and/or 3D depth data to the other components of the system for analysis.", "As the video camera is recording or otherwise transmitting video and/or 3D depth data to the other system components at all times during monitoring, the electronic device is able to immediately track, capture and/or record the monitored individual's movements at all times within the room or monitored area and will be able to provide information as to whether and when the individual begins to move or begins to get up to move.", "Preferably the 3D Camera, Motion and Sound Sensor records, captures and/or streams video and/or 3D depth data.", "As video is technically made up of individual picture frames (i.e.", "30 frames per second of video), the above reference to picture frames is referring to frames of video.", "Depth sensitivity can come into play with skeletal tracking in order to minimize false alarms, as objects behind and in front of the patient can be effectively ignored.", "The preferred use of depth as a factor also differentiates the current monitoring system from motion/object detection systems that rely on 2D images.", "The 3D Motion and Sound Sensor is located within the room of the patient being monitored and potentially just outside of the patient's room.", "It is connected to the computerized communication and computerized monitoring systems via a data connection (TCP/IP or comparable technology).", "Computerized Virtual A computer system specifically designed and programmed to create Safety Rail Monitoring virtual safety rails around a specific object such as a hospital bed and System which monitors activity based on information received from the 3D Camera, Motion and Sound sensor(s).", "The computerized monitoring system will preferably be located within the patient's room and can be connected to the centralized monitoring station at the facility but can also be located at any physical location so long as a data connection (TCP/IP or comparable technology) exists between the computerized monitoring system, the computerized communication system, centralized monitoring station and/or 3D motion and sound sensor.", "The computerized virtual safety rail monitoring system preferably makes its determinations based on the data received by the 3D Camera, Motion and Sound sensor(s).", "Computerized A computer system specifically designed and programmed to facilitate Communication System communication between the monitored patient and computerized monitoring system in the event the virtual safety rails are crossed.", "This system may include but is not limited to amplified speakers, microphones, lights, monitors, computer terminals, mobile phones and or other technologies to allow for the electronic communication to take place.", "The computerized communication system will preferably be located within the patients room being monitored but certain components of the system are mobile by their nature (i.e.", "mobile phones, pagers, computers) and can also be located at any location so long as a data connection (TCP/IP or comparable technology) exists between the computerized monitoring system, the computerized communication system, centralized monitoring station and 3D Camera, Motion and Sound sensor.", "System Database A computer database that stores records of all alerts generated, notifications, confirmation requests, responses, and reconfirmation requests and any other desired information concerning a triggering event or lack of triggering event(s).", "Centralized Monitoring A computer display connected to the centralized monitoring station, Primary Display showing video and audio of all patient rooms connected to the centralized monitoring station.", "Centralized Monitoring A computer display connected to the centralized monitoring station, Alert Display showing video and audio of any patient room where an individual is deemed to have crossed a virtual safety rail at the moment such determination is made.", "Caregiver A relative, friend, individual, company or facility whose purpose is to provide assistance in daily living activities for individuals who are disabled, elderly or otherwise in need of assistance.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a block diagram of a virtual safety rails configuration, monitoring and alerting system and method in accordance with the present invention; and FIG.", "2 is a block diagram of the centralizing monitoring and alerting system in accordance with the disclosure; and FIGS.", "3 though 15 illustrate various screen shots for configuring the system for operation including defining bed zone, virtual safety rails and alert types; and FIG.", "16 is a non-limiting example of a centralized video monitoring system that can be used with the system and method shown in FIG.", "1.DETAILED DESCRIPTION OF THE INVENTION FIG.", "1 illustrates a block diagram for the virtual safety rails configuration, monitoring and alerting system and method of the present invention.", "Specifically, FIG.", "1 shows the workflow for monitoring an individual's status through the use of one or more 3D Camera, Motion and Sound sensors.", "At step F1a, one or more 3D Camera, Motion and/or Sound sensors can be installed in the patient's or individual's room.", "At step F1b, the one or more 3D Motion and Sound sensors can be configured to recognize the individual using biometric identifiers such as height, distance between points on the body, etc.", "Virtual safety rails can also be calibrated at this time.", "At step F1c, data from the 3D Motion and Sound sensors can be sent to a Computerized Virtual Safety Rail Monitoring System.", "At step F1d, a continuous video feed can be sent to the central Video Monitoring System.", "At step F1e, if the computerized virtual safety rail monitoring system detects that the patient or any part of the patient has crossed outside of the designated perimeter (beyond the virtual safety rail), the monitoring system will alert the computerized communication system.", "A record can also be entered in a database to record the incident.", "If other individuals such as a caregiver are also detected at the time the virtual safety rail threshold is crossed, the system can be designed or programmed such that no alert is generated and it will continue to monitor the data being sent from the 3D camera, motion and sound sensor, Additionally, the system can be programmed to be capable of detecting pre-programmed hand, arm, leg and body gestures from the patient individual and/or another person in the room to initiate an alert to the computerized communication system.", "As a non-limiting example, a particular hand gesture could be used as a signal to send medical assistance or that the individual needs to use the restroom.", "Further examples are numerous.", "At step F1f, the computerized communication system preferably can first issue a verbal warning to the patient that they have crossed the virtual safety rail threshold.", "This verbal warning can be a pre-recorded message, including, but not limited to, a pre-recorded message from an caregiver, and will advise the patient to return to within the perimeter of the virtual safety rails.", "At step F1g, should the patient fail to return to within the perimeter of the virtual safety rails in a timely manner, an alert can be generated on the central Video Monitoring System (see FIG.", "2).", "The system database can also be updated to reflect actions taken.", "The system can be designed to provide visual and/or audio alerts.", "At step F1h, the computerized communication system can notify caregivers or other designated persons that the individual requires assistance.", "Notification of caregivers can be made through phone call, text messaging, speakerphone systems, pagers, email, or other electronic means of communication if so desired and configured.", "At step F1i, if the individual returns within the perimeter of the virtual safety rails, the system database can be updated to reflect such.", "Additionally, the system will continue to monitor the patient and store all data in the system database.", "Preferably, based on information received from the sensor(s), the computerized monitoring system can track skeletal points on a body of the specific individual being monitored in real time.", "The 3D Camera, Motion and Sound sensors continually capture data concerning the one or more rooms regardless of whether (and independent of) any movements or sounds have occurred in the one or more rooms.", "Thus, during monitoring, the 3D Camera, Motion and Sound sensors continually capture or receive data at all times and continually feed or send the data to the computerized monitoring system for processing and analysis involved in making the relevant determinations.", "The monitored individual or a person/caregiver with the monitored individual can received a message from the computerized communication system which is in communication with the computerized monitoring system to determine whether or not the individual needs assistance.", "In one embodiment, the computerized monitoring system detects or determines that the individual may have fallen or is about to fall or crossed over a virtual safety rail, solely from the video feed forwarded from the one or more 3D Camera, Motion and Sound sensors that shows that the individual has fallen or gestured that he or she needs assistance or moved over or through the electronically defined virtual safety rail.", "FIG.", "2 illustrates a block diagram for centralized monitoring and alerting and shows the workflow for centralized monitoring and alerting of the central monitoring regarding whether an individual has crossed a virtual safety rail threshold through the use of 3D Motion and Sound sensors.", "At step F2a, one or more 3D Motion and Sound sensors are installed in and/or just outside an individual's room, home, hospital room, or other place of temporary or permanent residence and connected to the computerized monitoring and communication systems as described in FIG.", "1.The video, audio and alert data can be sent to a centralized monitoring station where the data is aggregated.", "Preferably, the centralized monitoring station receives data at all times from the sensors to allow the various individuals to be constantly monitored at the centralized station regardless of whether or not a fall has been detected.", "At step F2b, all video, audio and alert feeds received by the centralized monitoring station can be displayed on the centralized monitoring primary display.", "Alternatively, multiple centralized monitoring primary displays can be utilized based on the quantity of rooms to be monitored at a given time.", "At step F2c, when the centralized monitoring system receives an alert from any of the computerized monitoring and communication systems indicating that an individual in any of the monitored rooms or other locations has fallen, the video, audio and alert information is displayed on the Centralized Monitoring Alert Display.", "Should the centralized monitoring station receive alerts from more then one of the computerized monitoring and communication systems indicating that an individual in a monitored room or location has crossed a virtual safety rail threshold, the centralized monitoring alert display will display the video, audio and alerting information from all such instances at the same time.", "If no alert is received by the centralized monitoring station, nothing is displayed on the Centralized Monitoring Alert Display.", "At step F2d, an electronic record of any alerts received by the Centralized Monitoring Station can be stored in an electronic database, which is in communication with the Centralized Monitoring Station.", "FIGS.", "3 through 15 illustrate several set up screen shots for configuring the bed zone, virtual safety rails and alert types.", "In FIG.", "3, the bed zone and virtual safety rails can be configured for a given or specific 3D Motion and Sound Sensor.", "To begin configuration, the user can hover over the 3D Motion and Sound Sensor video window with the cursor, right-click, select plugin and then select configure plug-in.", "A window will popup showing the 3D Motion and Sound Sensors' feed.", "The user selects the icon for the type of zone or rail they wish to draw, which as a non-limiting example and illustrative purposes, can be a bed zone and virtual safety rail(s) (See FIG.", "4).", "As non-limiting examples, the icons that appear on the screen for selection can include the following symbols shown in FIG.", "5 in this non-limiting example, in no particular order, some of the icons include, Bed Zone, Auto Bed Zone (Select Patient), Auto Bed Zone (Auto-select), Saved Zones, Virtual Safety Rail and Clear All.", "As seen in FIG.", "6, to place a zone, the user clicks on the screen where he or she would like to start the zone.", "Then, the cursor is moved to the corner point for zone and clicked again.", "The user continues to select additional points until the zone is drawn to the user's satisfaction.", "Preferably, the user clicks on the round end point of the beginning of the zone to complete the zone (See FIG.", "6).", "When the zone has been completed, the zone can appear and a depth range box (i.e.", "square, rectangle, etc.", "disposed over the patient on the screen) can be provided on the screen, such as, but not limited to, in the middle of the screen or zone (see FIG.", "8), though any location on the screen is considered within the scope of the invention.", "Placing a virtual rail is done with a similar process wherein the user clicks on the screen where he or she would like to start the rail.", "Then the cursor is moved to the end point for the rail and the user clicks on the screen again to place the rail.", "As seen in FIG.", "8, upon completion the zone and or rail(s) appear and has a depth range box preferably in the middle.", "As seen in FIG.", "7, the user can adjust the depth range for any given zone or rail.", "By preferably double clicking on the depth range box or by other conventional selection methods an Edit Depth window can appear.", "The user can enter in the depth ranges (preferably in millimeters (mm) though not considered limiting) and then the user can click Save button or icon when done to store the entered values.", "If there are any other types of zones or rails to draw for the particular sensor, the above steps are repeated to place the next zone or rail and the depth setting can be adjusted for each if necessary.", "Additionally, all zones and rails can be cleared by clicking on or otherwise selecting the Clear All icon in the toolbar.", "Once all of the zones/rails are configured, you can close the window to finish or you have the option to save the zone rail configuration for later use.", "As seen in FIG.", "9, to access the main settings window, the user can click or otherwise select the Settings menu and the select Main Settings from the drop-down list.", "As one non-limiting alternative, the user can click on the Gear icon () or other designated icon in the toolbar to access the main settings window.", "As seen in FIG.", "10, for one non-limiting way to configure a new Alert, the user can select the Alerts tabs and then click on or otherwise select the Add button, which can result in the Configure Alert box appearing on the screen (See FIG.", "11).", "As seen in FIG.", "11, under the Event field, the user can then select the event from the drop down list that they wish the user wishes to send an alert on.", "As seen in FIG.", "12, once the Event type is selected, under the Action field, the user can select the Action he or she wishes to have the system perform when the selected Event is detected.", "Once the Event and Action have be selected the OK button (See FIG.", "13) can be selected to save the selected entries.", "For certain Actions an additional field may need to be completed to finish the Action.", "If the field is required, it can appear below the Action dropdown (See FIG.", "14), If no further fields are required, the Configure Alert box can display N/A (See FIG.", "13) or just be blank.", "As mentioned above, once all settings are selected, the user clicks or otherwise selects the OK button, which causes the new Alert to be listed in the Alerts tab window.", "To edit an existing Alert, the user first clicks on or otherwise selects the Alert and then selects the Edit button (See FIG.", "15).", "To delete an Alert, first highlight it can then click on the Delete button (See FIG.", "15).", "To add more Alerts, the user clicks or selects the Add button and repeats the above described steps.", "Once finished, the user clicks on or otherwise selects the bottom corner OK button to save and close the window.", "FIG.", "16 shows a non-limiting example of a centralized video monitoring system that can be used with the system and method.", "The window highlighted in red is a non-limiting example of an alert that can be generated when the patient fails to return to within the perimeter of the virtual safety rails.", "The above described system uses several components, including, but not limited to: 1.One or more 3D Camera, Motion and/or Sound Sensors.", "However, it also within the scope of the invention to eliminate the sound sensor and have the functions of the invention be performed with only motion/camera functions; 2.A Computerized Virtual Safety Rail Monitoring System in electronic communication with the one or more 3D Camera, Motion and Sound sensors; 3.A Computerized Communication System in electronic communication with the Computerized Virtual Safety Rail Monitoring System; 4.A Centralized Monitoring Station in electronic communication with the one or more 3D Camera, Motion and Sound sensors, Computerized Virtual Safety Rail Monitoring System and/or Computerized Communication System; 5.A Centralized Monitoring Primary Display in electronic communication with one or more Centralized Monitoring Stations; 6.A Centralized Monitoring Alert Display in electronic communication with one or more Centralized Monitoring Stations; and/or 7.Database The various components can be in electrical, wired and/or wireless communication with each other.", "The automatic detection of an individual leaving a prescribed virtual perimeter will provide significant administrative and clinical benefits to caregivers and individuals alike, including the following non-limiting public benefits: 1.Automation of determination of perimeter violation and automated notification of caregivers or other designated entities.", "2.Ability to alert patients and caregivers in time to prevent patient from getting out of bed 3.Reduction in response time for individuals who have fallen and require assistance.", "4.Increased survival rate for individuals who have experienced a fall 5.Reduction in costs for hospitalization and medical care related to complications from a fall 6.Ability to distinguish multiple individuals and prevent false positives 7.Ability to distinguish direction of motion of prevent false positives 8.Ability to provide video feed of patient under all lighting conditions to the central video monitoring system 9.Audio and gesture based recognition to allow multiple forms of communication with patient.", "Any computer/server/electronic database system (collectively “Computer System”) capable of being programmed with the specific steps of the present invention can be used and is considered within the scope of the disclosure.", "Once programmed such Computer System can preferably be considered a special purpose computer limited to the use of two or more of the above particularly described combination of steps (programmed instructions) performing two or more of the above particularly described combination of functions.", "All components of the described system and their locations, electronic communication methods between the system components, electronic storage mechanisms, electronic notification technologies, etc.", "discussed above or shown in the drawings, if any, are merely by way of example and are not considered limiting and other component(s) and their locations, electronic communication methods, electronic storage mechanisms, electronic notification technologies, etc.", "can be chosen and used and all are considered within the scope of the disclosure.", "Unless feature(s), part(s), component(s), characteristic(s) or function(s) described in the specification or shown in the drawings for a claim element, claim step or claim term specifically appear in the claim with the claim element, claim step or claim term, then the inventor does not consider such feature(s), part(s), component(s), characteristic(s) or function(s) to be included for the claim element, claim step or claim term in the claim when and if the claim element, claim step or claim term is interpreted or construed.", "Similarly, with respect to any “means for” elements in the claims, the inventor considers such language to require only the minimal amount of features, components, steps, or parts from the specification to achieve the function of the “means for” language and not all of the features, components, steps or parts describe in the specification that are related to the function of the “means for” language.", "While the system and method have been described and disclosed in certain terms and has disclosed certain embodiments or modifications, persons skilled in the art who have acquainted themselves with the disclosure, will appreciate that it is not necessarily limited by such terms, nor to the specific embodiments and modification disclosed herein.", "Thus, a wide variety of alternatives, suggested by the teachings herein, can be practiced without departing from the spirit of the disclosure, and rights to such alternatives are particularly reserved and considered within the scope of the disclosure." ] ]
Patent_15872564
[ [ "Three-dimensional Printing System and Equipment Assembly", "A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided.", "The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system.", "The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system.", "The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects.", "It can be used to prepare single or multiple articles." ], [ "1) A method of preparing a three-dimensionally printed article, the method comprising: a) forming one or more layers of powder within a receptacle comprising a lower height adjustable platform (or punch), wherein the powder comprises at least one binder; b) depositing binding fluid on one or more powder layers within the receptacle to bind particles of the at least one binder and form one or more incremental printed layers; c) before completion of the 3DP article, translating, compressing, marking or shaping the one or more incremental printed layers in the receptacle with a punch system comprising at least one upper punch; and d) repeating steps a) and b), and optionally step c), to complete formation of the 3DP article.", "2) A method of preparing a three-dimensionally printed article, the method comprising: a) forming one or more layers of powder within a receptacle comprising a lower height adjustable platform (or punch), wherein the powder comprises at least one binder; b) depositing binding fluid onto the one or more powder layers to bind particles of the at least one binder and form a printed bed comprising loose unprinted powder and one or more incremental printed layers corresponding to one or more 3DP articles; c) before completion of the one or more 3DP articles, translating, compressing, marking or shaping the one or more incremental printed layers in the receptacle with a punch system comprising at least one upper punch; and d) repeating steps a) and b), and optionally step c), to complete formation of the one or more 3DP articles.", "3) The method of any one of the above claims, wherein: 1) an additional step c) is performed between steps a) and b); 2) step c) is performed before step b); 3) the process further comprises a drying step after step b), such that the amount of binding fluid in the one or more incremental printed layers is reduced prior to conducting step c); 4) steps a) and b) are repeated and step c) is conducted at least once during preparation of a 3DP article; 5) steps a), b) and c) are each repeated at least once during preparation of a 3DP article; 6) the minimal sequence of steps in the process is: i) step a), step b), drying, step c) and step d); ii) step a), step c), step b), drying, step c), and step d); and/or 7) step c) is performed while the receptacle is stationary.", "4) A method of preparing a 3DP article comprising at least one compressed, marked and/or shaped region, the method comprising: a) forming an incremental printed layer from a binding fluid and a powder comprising at least one binder; and b) compressing, marking and/or shaping the incremental printed layer with a punch system prior to completion of formation (printing) of the 3DP article, wherein the punch system comprises at least one upper punch.", "5) The method of claim 4 further comprising: forming another incremental printed layer before step a) or after step b).", "6) The method of any of the above claims, wherein the compressing, marking and/or shaping step is conducted: a) on each incremental printed layer of the 3DP article; or b) on at least one but less than all of the incremental printed layers of the 3DP article.", "7) A method of preparing a 3DP article, the method comprising: a) forming a powder layer in a cavity, wherein the powder layer comprises at least one binder; b) depositing or printing liquid onto the powder layer in the cavity to bind particles of the at least one binder and form an incremental printed layer; and c) translating, compressing, marking and/or shaping the powder layer and/or incremental printed layer with a punch system comprising at least one upper punch.", "8) The method of claim 7, wherein steps a) and b) are repeated to form plural incremental printed layers.", "9) The method any one of the above claims, wherein step c) is repeated at least once.", "10) A method of preparing a 3DP article, the method comprising: a) forming a powder layer in a cavity; b) depositing or printing liquid onto the powder layer in the cavity to form a incremental printed layer; c) forming another powder layer in the cavity; and d) simultaneously translating, compressing, marking and/or shaping the powder layer and incremental printed layer with a punch system comprising at least one upper punch.", "11) The method of claim 10, wherein steps a) and b), and optionally step c), are repeated to form plural incremental printed layers.", "12) The method any one of the above claims, wherein step d) is repeated at least once.", "13) The method of any one of the above claims further comprising drying the incremental printed layer before or after translating, compressing, marking and/or shaping.", "14) A three-dimensionally printed (3DP) article having regions that differ in void fraction (density), wherein each region comprises one or more incremental printed layers, and at least one region has been compressed, and another region has not been compressed.", "15) The article of claim 14, wherein: a) plural incremental printed layers are present and at least one incremental printed layer is compressed; b) plural incremental printed layers are present, at least one incremental printed layer is a compressed layer and at least one incremental printed layer is an uncompressed (non-compressed) layer; or c) plural incremental printed layers are present and plural uncompressed incremental printed layers are present.", "16) The article of any one of the above claims, wherein at least one compressed layer is uniformly compressed, at least one compressed layer is non-uniformly compressed, or a combination thereof.", "17) A 3DP equipment assembly (system or apparatus) comprising: a conveyor system that conducts plural build modules, wherein the plural build modules comprise respective receptacles and height adjustable platforms; at least one powder layering region (or system) that forms layers of powder in the plural build modules; at least one binding fluid application region (or system) that deposits binding fluid onto the layers of powder; and at least one punch region (or system) comprising at least one upper punch.", "18) The assembly of claim 17 further comprising a drying region (or system) and a discharge (article transfer) region (or system).", "19) The assembly of any one of the above claims, wherein: a) the powder receptacle receives a powder when in the powder layering region to form a powder layer in the receptacle; b) binding fluid is applied to the powder layer when the receptacle is in the binding fluid application region to form an incremental printed layer in the receptacle; and c) either the powder layer or the incremental printed layer in the receptacle is punched in the punch region, wherein the punching may result in translating, compressing, marking and/or shaping of the powder layer or incremental printed layer 20) The assembly of claim 19, wherein: a) one or more incremental printed layers are translated, compressed, marked and/or shaped in the punch region; b) one or more incremental printed layers are not compressed in the punch region; or c) one or more incremental printed layers are translated, compressed, marked and/or shaped in the punch region, and one or more incremental layers are not translated, compressed, marked and/or shaped in the punch region.", "21) The assembly or apparatus of any one of claims 17-19 or 20, wherein the receptacle moves: a) from the powder layering region to the binding fluid application region and then to the punch region; b) from the powder layering region to the punch region and then to the binding fluid application region; c) from the powder layering region to the binding fluid application region then back to the powder layering region and then to the punch region; or d) from the powder layering region to the binding fluid application region to the drying region and then to the punch region.", "22) A three-dimensional printing equipment assembly comprising: a) a three-dimensional printing build system comprising: at least one build module comprising at least one powder receptacle and height adjustable platform (or punch) disposed within the receptacle; at least one power layering system for forming a powder layer by depositing powder within the receptacle; at least one binding fluid deposition system for depositing binding fluid to the powder layer to form an incremental printed layer; at least one punch system for translating, compressing, marking or shaping a powder layer or incremental printed layer within the receptacle, wherein the punch system comprises at least one upper punch; and a conveyor system that conducts the at least one build module to the powder layering system, the fluid deposition system and the punch system.", "23) The equipment assembly of any one of the above claims further comprising: a) at least one layer drying system for in-process drying of an incremental printed layer after formation thereof and/or b) at least one article drying system for drying of 3DP articles after completion of formation thereof.", "24) The equipment assembly any one of the above claims, wherein: a) the equipment assembly (or apparatus) further comprises a conveyor system adapted to conduct plural build modules; b) the equipment assembly further comprises at least one liquid removal system (article drying system) that receives one or more 3DP articles and removes liquid there from; c) the build system further comprises at least one liquid removal system (layer drying system) that removes liquid from one or more incremental layers prior to completion of a build cycle, i.e.", "between formation of incremental layers; d) the equipment assembly (or apparatus) further comprises an article transfer system that transfers 3DP articles, one or more at a time, away from the three-dimensional printing build system; e) the equipment assembly (or apparatus) further comprises a dedusting system that removes loose particles from 3DP articles; f) the equipment assembly (or apparatus) further comprises one or more control systems; g) the equipment assembly (or apparatus) further comprises one or more inspection systems.", "25) The equipment assembly any one of the above claims, wherein: a) the conveyor system repeatedly transports the build modules between the at least one powder layering system, the at least one printing system and the at least one punch system to form at least one article within a build module; b) the conveyor system repeatedly transports the build modules between the at least one powder layering system, the at least one printing system, the at least one layer drying system and the at least one punch system to form at least one article within a build module; c) the conveyor system repeatedly transports the build modules between the at least one powder layering system and the at least one printing system to form at least one article within a build module; or a d) combination thereof.", "26) A three-dimensional printing equipment assembly comprising: a) a three-dimensional printing build system comprising: a conveyor system that conducts plural build modules and comprises positioning-controller and plural build module engagements; plural build modules engaged with the conveyor system, wherein the build modules receive and temporarily retain powder from a powder layering system, and wherein a build module comprises: 1) one or more sidewalls defining a cavity; and 2) an incrementally height adjustable platform (lower punch) disposed within the cavity; at least one build station comprising: 1) at least one powder layering system that forms incremental powder layers within the cavity and comprises at least one powder fill head, at least one powder spreader and at least one powder reservoir; and 2) at least one printing system that applies a liquid according to at least one predetermined pattern to the incremental powder layers and comprises at least one liquid feed system and at least one print head that deposits liquid according to the at least one predetermined pattern; at least one punch system comprising at least one upper punch; wherein the conveyor system repeatedly transports the plural build modules from the at least one powder layering system to the at least one printing system, whereby the three-dimensional printing build system: 1) forms at least one incremental printed layer per build lap in a build module; 2) forms a single 3DP article per build cycle in a build module; 3) forms plural 3DP articles per build cycle in a build module; or 4) forms a 3DP bed comprising one or more three-dimensionally printed articles and, optionally, loose (unbound or only partially bound) powder that has not been printed upon per build cycle in a build module; 27) The three-dimensional printing equipment assembly of any one of the above claims further comprising: a) at least one harvesting system that separates loose powder from: 1) one or more incremental printed layers; 2) one or more 3DP articles; or 3) one or more 3DP beds; and/or c) at least one liquid removal system that removes liquid from: 1) one or more incremental printed layers of an in-process incompletely formed 3DP article; 2) one or more 3DP articles after printing thereof; or 3) one or more 3DP beds.", "28) A three-dimensional printing equipment assembly comprising: a) a three-dimensional printing build system comprising: at least one build module comprising a powder-receiving receptacle having a top plan view defined by a first periphery and having a height adjustable platform (or punch) disposed within the receptacle; at least one power layering system for forming a powder layer by depositing powder within the receptacle; at least one binding fluid deposition system for depositing binding fluid to the powder layer to form an incremental printed layer; at least one punch system comprising at least one upper punch having an upper or lower plan view defined by a second periphery with a top plan view approximating that of the first periphery; and a conveyor system that conducts the at least one build module to the powder layering system, the binding fluid deposition system and the punch system.", "29) A three-dimensional printing equipment assembly comprising: a) a three-dimensional printing build system comprising: a conveyor system that conducts plural build modules; plural build modules engaged with the conveyor system, wherein the build modules receive and temporarily retain powder from a powder layering system, and wherein a build module comprises: 1) one or more sidewalls defining one or more cavities, a top plan view of which is defined by a first periphery; and 2) an incrementally height adjustable platform (lower punch) disposed within the cavity; at least one build station comprising: 1) at least one powder layering system that forms incremental powder layers within the cavity and comprises at least one powder fill head, at least one powder spreader and at least one powder reservoir; and 2) at least one printing system that applies a liquid according to at least one predetermined pattern to the incremental powder layers and comprises at least one liquid feed system and at least one print head that deposits liquid according to the at least one predetermined pattern, wherein the predetermined pattern comprises a second periphery approximating the respective first periphery; wherein the conveyor system repeatedly transports the plural build modules from the at least one powder layering system to the at least one printing system, whereby the three-dimensional printing build system forms at most a single 3DP article per build cycle per said one or more cavities.", "30) A three-dimensionally printed (3DP) article comprising at least two incremental printed layers, wherein: at least one printed incremental layer comprises a first region and a horizontally adjacent second region; the first region is prepared from a first bulk powder and first binding fluid; the second region is prepared from a second bulk powder and second binding fluid; and the first bulk powder is different from the second bulk powder.", "31) The article of any one of the above claims, wherein: a) the first binding fluid and the second binding fluid are the same; b) the first binding fluid and the second binding fluid are different.", "32) The article of any one of the above claims, wherein: a) the first binding fluid and the second binding fluid have different compositions; and/or b) the first bulk powder and the second bulk powder have different compositions.", "33) An invention comprising a combination of any two or more of the claims herein.", "34) An invention substantially as described herein.", "35) An invention substantially as described in one or more of the drawings.", "36) A method of preparing a three-dimensionally printed article, the method comprising: a) forming one or more layers of powder within a receptacle comprising a lower height adjustable platform (or lower punch), wherein the inner periphery of a top plan view of the receptacle and the outer periphery of a top plan view of the platform (or lower punch) approximates the outer periphery of a plan view of the article; b) depositing binding fluid at or near the periphery of the one or more powder layers within the receptacle to form one or more incremental printed layers defined by a print pattern, the outer periphery of which has a top-plan view approximating the inner periphery of the receptacle; c) before completion of the 3DP article, translating, compressing, marking or shaping the one or more incremental printed layers in the receptacle with an upper or lower punch system; and d) repeating steps a) and b), and optionally step c), to complete formation of the 3DP article.", "37) The assembly of any one of the above claims, wherein the predetermined pattern comprises a second periphery approximating the first periphery.", "38) A three-dimensional printing equipment assembly comprising: a) a three-dimensional printing build system comprising: at least one build module comprising a powder-receiving receptacle having a top plan defined by a first periphery and having a height adjustable platform (or punch) disposed within the receptacle; at least one power layering system for forming a powder layer by depositing powder within the receptacle; at least one binding fluid deposition system for depositing binding fluid to the powder layer to form an incremental printed layer, wherein the fluid is deposited according to a pattern comprising a second periphery with a top plan view approximating that of the first periphery.", "39) The assembly of any one of the above claims, wherein the fluid is deposited according to a pattern comprising a second periphery with a top plan view approximating that of the first periphery.", "40) A three-dimensional printing equipment assembly comprising: a) a three-dimensional printing build system comprising: a conveyor system that conducts plural build modules; plural build modules engaged with the conveyor system, wherein the build modules receive and temporarily retain powder from a powder layering system, and wherein a build module comprises: 1) one or more sidewalls defining a cavity, a top plan view of which is defined by a first periphery; and 2) an incrementally height adjustable platform (punch) disposed within the cavity; at least one build station comprising: 1) at least one powder layering system that forms incremental powder layers within the cavity and comprises at least one powder fill head, at least one powder spreader and at least one powder reservoir; and 2) at least one printing system that applies a liquid according to at least one predetermined pattern to the incremental powder layers and comprises at least one liquid feed system and at least one print head that deposits liquid according to the at least one predetermined pattern, wherein the predetermined pattern comprises a second periphery approximating the first periphery; wherein the conveyor system repeatedly transports the plural build modules from the at least one powder layering system to the at least one printing system, whereby the three-dimensional printing build system: 1) forms at least one incremental printed layer per build lap in a build module; 2) forms a single 3DP article per build cycle in a build module; 3) forms plural 3DP articles per build cycle in a build module; or 4) forms a 3DP bed comprising one or more three-dimensionally printed articles and, optionally, loose (unbound or only partially bound) powder that has not been printed upon per build cycle in a build module.", "41) The assembly of any one of the above claims, wherein the conveyor is a staged conveyor, turret assembly, belt conveyor, wheel conveyor, roller conveyor, chain conveyor, wire mesh conveyor, plate conveyor, slat conveyor, magnetic conveyor, bucket conveyor, cart-on-track conveyor.", "42) The assembly of claim 41, wherein the turret assembly comprises a removable upper disc comprising plural receptacles and a lower disc comprising plural punches (incrementally height adjustable platforms) vertically aligned with respective receptacles of the upper disc.", "43) The assembly of claim 41 or 42 further comprising a turret disc replacement system.", "The method of any one of the above claims, wherein the binding fluid comprises at least one binder.", "44) The method of any one of the above claims, wherein the powder comprises at least one binder.", "45) The assembly of any one of the above claims, wherein the binding fluid comprises at least one binder.", "46) The assembly of any one of the above claims, wherein the powder comprises at least one binder." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Rapid prototyping describes various techniques for fabricating a three-dimensional prototype of an object from a computer model of the object.", "One technique is three-dimensional printing, whereby a printer is used to fabricate the 3-D prototype from a plurality of two-dimensional layers.", "In particular, a digital representation of a 3-D object is stored in a computer memory.", "Computer software sections the representation of the object into a plurality of distinct 2-D layers.", "Alternatively, a stream (sequential series) of instructions for each incremental layer maybe entered directly, e.g.", "a series of images.", "A 3-D printer then fabricates a thin layer of bound material for each 2-D image layer sectioned by the software.", "Together, the layers are printed one on top of the other and adhere to each other to form the desired prototype.", "Three-dimensional powder-liquid printing technology has been used to prepare articles such as pharmaceutical dosage forms, mechanical prototypes and concept models, molds for casting mechanical parts, bone growth promoting implants, electronic circuit boards, scaffolds for tissue engineering, responsive biomedical composites, tissue growth promoting implants, dental restorations, jewelry, fluid filters and other such articles.", "Three-dimensional printing is a solid freeform fabrication technique/rapid-prototyping technique in which thin layers of powder are spread onto a surface and selected regions of the powder are bound together by the controlled deposition (“printing”) of a fluid.", "This basic operation is repeated layer-by-layer, with each new layer formed on top of and adhered to the previously printed layer, to eventually make three-dimensional objects within a bed of unbound powder.", "When the printed objects have sufficient cohesion, they may be separated from the unbound powder.", "Systems and equipment assemblies for three-dimensional printing of articles are commercially available or in use by others: Massachusetts Institute of Technology Three-Dimensional Printing Laboratory (Cambridge, Mass.", "), Z Corporation's 3DP and HD3DP™ systems (Burlington, Mass.", "), The Ex One Company, L.L.C.", "(Irwin, Pa.), Soligen (Northridge, Calif.), Specific Surface Corporation (Franklin, Mass.", "), TDK Corporation (Chiba-ken, Japan), Therics L.L.C.", "(Akron, Ohio, now a part of Integra Lifesciences), Phoenix Analysis & Design Technologies (Tempe, Ariz.), Stratasys, Inc.'s Dimension™ system (Eden Prairie, Minn.), Objet Geometries (Billerica, Mass.", "or Rehovot, Israel), Xpress3D (Minneapolis, Minn.), and 3D Systems' Invision™ system (Valencia, Calif.).", "Some systems have been described in the patent literature: U.S. Publications No.", "20080281019, No.", "20080277823, No.", "20080275181, No.", "20080269940, No.", "20080269939, No.", "20080259434, No.", "20080241404, No.", "20080231645, No.", "20080229961, No.", "20080211132, No.", "20080192074, No.", "20080187711, No.", "20080180509, No.", "20080138515, No.", "20080124464, No.", "20080121172, No.", "20080121130, No.", "20080118655, No.", "20080110395, No.", "20080105144, No.", "20080068416, No.", "20080062214, No.", "20080042321, No.", "20070289705, No.", "20070259010, No.", "20070252871, No.", "20070195150, No.", "20070188549, No.", "20070187508, No.", "20070182799, No.", "20070182782, No.", "20070168815, No.", "20070146734, No.", "20060268057, No.", "20060268044, No.", "20060230970, No.", "20060141145, No.", "20060127153, No.", "20060111807, 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"20010017085; U.S. Pat.", "No.", "5,490,962, No.", "5,204,055, No.", "5,121,329, No.", "5,127,037, No.", "5,252,264, No.", "5,340,656, Nos.", "5,387,380, 5,490,882, No.", "5,518,680, No.", "5,717,599, No.", "5,851,465, No.", "5,869,170, No.", "5,874,279, No.", "5,879,489, No.", "5,902,441, No.", "5,934,343, No.", "5,940,674, No.", "6,007,318, No.", "6,146,567, No.", "6,165,406, No.", "6,193,923, No.", "6,200,508, No.", "6,213,168, No.", "6,336,480, No.", "6,363,606, No.", "6,375,874, No.", "6,416,850, No.", "6,508,971, No.", "6,530,958, No.", "6,547,994, No.", "6,596,224, No.", "6,772,026, No.", "6,838,035, No.", "6,850,334, No.", "6,905,645, No.", "6,945,638, No.", "6,989,115, No.", "7,220,380, No.", "7,291,002 No.", "7,365,129, No.", "7,435,368, No.", "7,455,804, No.", "7,686,955, No.", "7,828,022, No.", "8,017,055, No.", "8,888,480; PCT International Publications No.", "WO 00/26026, No.", "WO 98/043762, No.", "WO 95/034468, No.", "WO 95/011007, No.", "WO 2014/039378; and European Patent No.", "1,631,440, which employs a cylindrical (radial or polar) coordinate-based system due to its construction.", "Three-dimensional printing systems employing powder and binding fluid typically form articles by placing layers of powder within a receptacle and depositing binding fluid on the individual layers of powder.", "The binding fluid is applied in patterns to regions of the powder in each layer such that unbound powdered material remains on the outer periphery of the patterns.", "The printed articles, which comprise bound powder, are then separated from substantial amounts of unbound powder.", "Such processes undesirably require wasting or recycling the unbound powder.", "It would be a substantial improvement in the field to provide an equipment assembly, system and method for substantially reducing or eliminating the need to waste or recycle unbound powder.", "Three-dimensional printing systems have most often been directed to the manufacturing of custom or “one-off” parts, or in some cases toward mass customization.", "This may include fabrication of many different parts exhibiting different sizes and shapes from one another, either in a series of separate build cycles or in some cases within different processing regions of the same build cycle.", "The goal of flexibility and customization without tooling has led many of these systems to use large open beds, which further contribute to potential issues of waste or recycling of unbound powder when dealing with powder-liquid three-dimensional printing.", "These systems are not as well suited to the manufacturing of large numbers of identical parts, and it would be a substantial improvement in the field to provide an equipment assembly, system and method that is amenable to manufacturing of large numbers of identical parts while reducing or eliminating the need to waste or recycle unbound powder.", "To date, there has been no disclosure of a system employing any type of compression during formation (during the print cycle of the process) of a three-dimensionally printed article.", "The only types of compression for 3DP articles have been cold isostatic pressing or uniaxial compression, in each case after formation of the article, meaning after the print cycle and drying cycle have been completed.", "Uniaxially compressed three-dimensionally printed dosage forms are known (U.S. Pat.", "No.", "7,931,914, U.S. Pat.", "No.", "8,758,658 and WO 2003/037607, which overcome certain disadvantages cited for cold isostatic pressing).", "They are made by first completing the three-dimensional printing part of the process, drying the dosage form and then uniaxially compressing the dosage form.", "If cold isostatic compression is used, a temporary elastomeric bag or mold is required for each article to be immersed in a confined liquid used to apply the pressure uniformly to all surfaces, after which the bag or mold is removed.", "In either case, such a system and process does not allow for the formation of three-dimensionally printed articles having controlled and varying void fraction among the individual layers of the printed articles, because compression is performed on the entire printed article.", "Such a system and process cannot form a three-dimensionally printed article comprising a more tightly compressed lower region (a higher density portion) and a more loosely compressed or even uncompressed upper region (a lower density portion).", "It would be a substantial improvement in the field to provide an equipment assembly, system and method for the preparation of three-dimensionally printed articles comprising upper and lower portions differing in density (or void fraction)." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present invention provides a manufacturing system and equipment assembly useful for the preparation of articles by three-dimensional printing.", "The system and assembly can be used for high through-put continuous, semi-continuous, or batch manufacture with minimal product loss, high efficiency, and high product reproducibility in the context of flexible article design.", "The invention can provide a substantial reduction in or elimination of waste unbound powder as compared to other three-dimensional printing (3DP) processes.", "Cavity 3DP provides for most, substantially all or all of the solid material entering each cavity to be incorporated into a corresponding single 3DP article.", "The term cavity refers to the receptacle which receives the solid material.", "The receptacle can be part of a build module.", "In some embodiments, powdered solid material and liquid material are combined to form the article in the cavity.", "In some aspects, the invention provides a three-dimensional printing equipment assembly (or apparatus) comprising: a) a three-dimensional printing build system comprising: at least one powder layering region (or system); at least one binding fluid application region (or system); and at least one powder receptacle movable between the regions, wherein the inner periphery of a top plan view of the powder receptacle approximates the outer periphery of a plan view of an article to be prepared with the build system.", "Embodiments of the invention include those wherein: a) the equipment assembly comprises plural powder receptacles; b) the powder receptacles are arranged sequentially with respect to their direction of approach to the powder layering system; c) the powder receptacle is part of a build module; and/or d) a height adjustable platform is disposed within the receptacle.", "In some aspects, the invention provides a three-dimensional printing equipment assembly (or apparatus) comprising: a) a three-dimensional printing build system comprising: at least one build module comprising at least one receptacle (cavity) that receives and temporarily retains powder from a powder layering system, wherein the receptacle has a top plan view periphery that approximates the periphery of a plan view of an article to be prepared with the equipment assembly; and at least one build station comprising: 1) at least one powder layering system that deposits powder within the receptacle; and 2) at least one printing system that applies binding fluid at least to the periphery of powder layer(s) within proximity of the periphery of the receptacle.", "In some embodiments, the equipment assembly (or apparatus) further comprises: a) a liquid removal system; b) a 3DP article dedusting system; c) a packaging system; e) a punch system; f) a punch system comprising at least one upper punch and at least one lower punch; g) a punch system comprising an upper punch having a bottom plan view with a periphery approximating the periphery of the receptacle; h) a lower punch having a top plan view with a periphery approximating the periphery of the receptacle; i) the punch further comprises a seal between the punch and the inner surface of the receptacle; j) a height adjustable platform in the receptacle and an upper punch; k) a height adjustable platform in the receptacle; l) a height adjustable platform in the receptacle, wherein the periphery of a top plan view of the platform approximates the inner periphery of the receptacle; m) an air relief means to release displaced air or equalize air pressure when an upper punch enters a cavity; n) a servo motor control on the upper punch, lower punch, or both; o) a positioning system on the upper punch, lower punch, or b both, in each case comprising a ball screw characterized by a lead accuracy V300p value that is less than or equal to about 50 microns, or less than or equal to about 20 microns, or less than or equal to about 10 microns, or less than or equal to about 5 microns.", "In some embodiments, the periphery of the receptacle approximates the periphery of a plan view of a single article to be prepared.", "The periphery of the receptacle, the upper punch and the height adjustable platform approximates the periphery of a plan view of a single article to be prepared.", "The invention also includes embodiments wherein: a) the receptacle has a top-plan view surface area approximating (within 20%, within 15%, within 10%, within 5%, within 1% or within 0.5% of) or the same as the plan view surface area of the article to be prepared; b) the receptacle has a top-plan view approximating or the same as a plan view of the article to be prepared; and/or c) the receptacle has a top-plan view periphery approximating or the same as a plan view periphery of the article to be prepared.", "In some embodiments, the weight percentage of powder entering each cavity that is incorporated into a corresponding single final article is >80%, >90%, >95%, >98%, >99% or 100%.", "In some embodiments, the process is a zero-waste process in that solid material is neither recycled nor disposed of following completion of a build cycle.", "During a 3DP build cycle using a cavity 3DP apparatus or equipment assembly, a layer of powder is placed within the cavity (receptacle), droplets of binding fluid are applied at or near the periphery of the powder to form an incremental layer having a top-plan view approximating the periphery of the cavity.", "A drying step is optionally conducted following the application step prior to placing another layer of powder in the cavity.", "Steps of the process are repeated to form plural incremental layers within the cavity.", "Following completion of the build cycle, the 3DP article is discharged from the cavity.", "The 3DP article is optionally dried, optionally dedusted, and/or optionally packaged.", "In some aspects, the invention provides a method of preparing a three-dimensionally printed article, the method comprising: forming a layer of powder within a receptacle, wherein the inner periphery of a top plan view of the receptacle approximates the outer periphery of a plan view of the article; depositing binding fluid at or near the periphery of the powder layer within the receptacle to form an incremental layer defined by a print pattern, the outer periphery of which has a top-plan view approximating the inner periphery of the cavity.", "Embodiments of the invention include those wherein: a) the process further comprises providing a receptacle, the top plan view of which is defined by an inner periphery that approximates the outer periphery of a plan view of the article; b) the process further comprises depositing binding fluid to the powder within the region defined by the print pattern; c) the powder has an average particle size, and the outer periphery of the print pattern in an incremental layer is spaced away from the inner periphery of the receptacle a distance that is 0.1, 0.5, 1, 2, 5, or 10-fold of the average particle size, or is selected from the ranges of 0.1- to 1-fold, 0.5 to 2-fold, 1- to 5-fold, or 5- to 10-fold of the average particle size; d) after the step of depositing, the incremental layer comprises a band of powder (unprinted powder, loose powder, unbound powder) that is 0.1, 0.5, 1, 2, 5, or 10-fold of the average particle size, or is selected from the ranges of 0.1- to 1-fold, 0.5 to 2-fold, 1- to 5-fold, or 5- to 10-fold of the average particle size, with the band situated between the inner periphery of the receptacle and the outer periphery of the print pattern; e) the forming and depositing steps are repeated to form the 3DP article; f) the outer periphery of print pattern in an incremental layer encloses an area comprising printed powder, unprinted powder or a combination thereof; f) the plan view of the article is a side plan view, top plan view, bottom plan view or a silhouette of a perspective view of the article; g) the outer periphery of the print pattern of an incremental layer is adjacent the inner periphery of the receptacle; h) a combination of any of the above.", "In some embodiments: a) the periphery of the receptacle (cavity) is not shaped as a square, or rectangle, or star (e.g., 5 -pointed star), or other shape with a plurality of sharp, thin edges, corners, or protrusions that extend away from the center of receptacle (cavity); b) the periphery of the receptacle comprises a geometric shape, non-geometric shape or combination thereof; c) a single article is formed within each receptacle; d) the print pattern is for an incremental layer of a single article; e) no unprinted (unbound) powder remains in the receptacle; f) unprinted powder remains within the area of an incremental layer defined by the outer periphery of the print pattern; g) one or more incremental layers are formed by depositing binding fluid more than once to a layer of powder; h) the rate of application or deposition (mL/cm 2 or mL/min or mL/sec) of binding fluid is the same across all incremental layers; i) the rate of application or deposition of binding fluid is different between at least two incremental layers of a 3DP article; j) each incremental layer is formed by depositing binding fluid only once to its respective layer of powder; k) one or more cavities can be characterized as have a longest linear dimension, and the longest linear dimension of a cavity, or of each cavity, is less than or equal to 12 inches, 6 inches, 3 inches, 2 inches, or 1 inch in length; l) the cavities are housed within, or defined by, or housed within and defined by openings within a turret member; m) the process is characterized by continuous motion of one or more cavities during the spreading and printing steps; n) the process is characterized by stopping of one or more cavities to allow for optional translating, compressing, marking or shaping the one or more incremental printed layers using the upper punch.", "In some aspects, the invention provides a method of preparing a three-dimensionally printed article, the method comprising: a) forming one or more layers of powder within a receptacle comprising a lower height adjustable platform (or punch), wherein the inner periphery of a top plan view of the receptacle and the outer periphery of a top plan view of the platform (or punch) approximates the outer periphery of a plan view of the article; b) depositing binding fluid at or near the periphery of the one or more powder layers within the receptacle to form one or more incremental printed layers defined by a print pattern, the outer periphery of which has a top-plan view approximating the inner periphery of the receptacle; c) before completion of the 3DP article, translating, compressing, marking or shaping the one or more incremental printed layers in the receptacle with a punch system; and d) repeating steps a) and b), and optionally step c), to complete formation of the 3DP article.", "In some aspects, the invention provides a method of preparing a three-dimensionally printed article, the method comprising: a) forming one or more layers of powder within a receptacle comprising a lower height adjustable platform (or punch); b) according to a print pattern, depositing binding fluid onto the one or more powder layers to form a printed bed comprising loose unprinted powder and one or more incremental printed layers corresponding to one or more 3DP articles; c) before completion of the one or more 3DP articles, translating, compressing, marking or shaping the one or more incremental printed layers in the receptacle with a punch system; and d) repeating steps a) and b), and optionally step c), to complete formation of the one or more 3DP articles.", "Some embodiments of the invention include those wherein: 1) an additional step c) is performed between steps a) and b); 2) step c) is performed before step b); 3) the process further comprises a drying step after step b), such that the amount of binding fluid in the one or more incremental printed layers is reduced prior to conducting step c); 4) steps a) and b) are repeated and step c) is conducted at least once during preparation of a 3DP article; 5) steps a), b) and c) are each repeated at least once during preparation of a 3DP article; 6) the minimal sequence of steps in the process is: i) step a), step b), drying, step c) and step d); ii) step a), step c), step b), drying, step c), and step d); and/or 7) step c) is performed while the receptacle is stationary.", "The punch system can comprise an upper punch disposed above the height adjustable platform (or above a lower punch) such that the incremental printed layer(s) is(are) between the two.", "The translating step can be conducted by lowering the platform the same (or approximately or about the same) vertical distance as the upper punch.", "The compressing step can be conducted by: a) lowering the platform a first vertical distance and lowering the upper punch a second vertical distance, which is greater than the first vertical distance; b) first, lowering the upper punch and second lowering the platform; c) maintaining the upper punch at a position and raising the platform; d) lowering the upper punch and raising the platform; or e) first, raising the platform and second raising the upper punch.", "The invention also provides three-dimensionally printed (3DP) articles having regions (comprising one or more incremental printed layers) that differ in void fraction (density), wherein at least one region has been compressed and another region has not been compressed.", "The 3DP article comprises plural incremental printed layers, wherein at least one incremental printed layer is compressed.", "In some embodiments, the 3DP article comprises plural incremental printed layers, wherein at least one incremental printed layer is a compressed layer and at least one incremental printed layer is an uncompressed (non-compressed) layer.", "The compressed layer can have a lower void fraction and higher density than the uncompressed layer.", "In some embodiments, the 3DP article comprises plural compressed incremental printed layers and at least one uncompressed incremental printed layer.", "In some embodiments, the 3DP article comprises plural compressed incremental printed layers and plural uncompressed incremental printed layers.", "In some embodiments, the compressed layer is uniformly compressed, and in some embodiments the layer is non-uniformly compressed.", "The invention provides a 3DP article comprising at least one uniformly compressed incremental layer and at least one non-uniformly compressed incremental layer.", "In some embodiments, the invention excludes a 3DP article that has been compressed solely by uniaxial compression following completion of a build cycle (formation of all incremental layers) or following drying of the article.", "The at least one compressed incremental printed layer is formed during a build lap before completion of a build cycle.", "The invention provides a process, equipment assembly/apparatus for preparing a 3DP article comprising at least one compressed, marked or shaped incremental printed layer.", "The process comprises compressing, marking and/or shaping one or more incremental printed layers during formation (during the build cycle) of the 3DP article.", "A 3DP article comprising at least one compressed, marked and/or shaped region can be made by a process comprising: a) forming an incremental printed layer; and b) compressing, marking and/or shaping the incremental printed layer with a punch system prior to completion of formation (printing) of the 3DP article.", "The process can further comprise: forming another incremental printed layer before step a) or after step b).", "In some embodiments, the compressing, marking and/or shaping step is conducted on each incremental printed layer of a 3DP article or on at least one but less than all of the incremental printed layers of a 3DP article.", "The invention also includes a three-dimensionally printed (3DP) article comprising at least two incremental printed layers, wherein: at least one printed incremental layer comprises a first region and a horizontally adjacent second region; the first region is prepared from a first bulk powder and first binding fluid; the second region is prepared from a second bulk powder and second binding fluid; and the first bulk powder is different from the second bulk powder.", "The first binding fluid and the second binding fluid can be the same or different.", "The first binding fluid and the second binding fluid can have different compositions.", "The first bulk powder and the second bulk powder can have the same or different compositions.", "In some embodiments, the process comprises: forming a powder layer in a cavity; depositing or printing liquid onto the powder layer in the cavity to form an incremental printed layer; and translating, compressing, marking and/or shaping the powder layer and/or incremental printed layer.", "In some embodiments, the process comprises: forming a powder layer in a cavity; depositing or printing liquid onto the powder layer in the cavity to form a incremental printed layer; forming another powder layer in the cavity; and simultaneously translating, compressing, marking and/or shaping the powder layer and incremental printed layer.", "The process can further comprise drying the incremental printed layer before or after translating, compressing, marking and/or shaping.", "The steps are repeated as needed to form a 3DP article comprising a full complement of incremental printed layers required to complete its structure.", "In some embodiments, the invention excludes a process wherein a three-dimensionally printed article has been compressed solely by uniaxial compression following completion of a build cycle, following completion of formation (printing) of the article or following drying of the article.", "The invention also provides a 3DP equipment assembly (or apparatus) and process for translating, compressing, marking and/or shaping one or more incremental layers after formation thereof but before completion of a build cycle, which forms one or more 3DP articles.", "In some aspects, the 3DP equipment assembly (or apparatus) comprises: at least one powder layering region (or system); at least one binding fluid application region (or system); at least one punch region (or system); and at least one powder receptacle movable between the regions.", "The equipment assembly (or apparatus) can further comprise a drying region (or system) and a discharge (article transfer) region (or system).", "The powder receptacle receives a powder when in the powder layering region to form a powder layer in the receptacle.", "Binding fluid is applied to the powder layer when the receptacle is in the binding fluid application region to form an incremental printed layer in the receptacle.", "Material (either powder layer or incremental printed layer) in the receptacle is punched in the punch region, wherein the punching may result in translating, compressing, marking and/or shaping of the powder layer or incremental printed layer depending upon how the punch is conducted.", "In some embodiments, one or more incremental printed layers are translated, compressed, marked and/or shaped in the punch region.", "In some embodiments, one or more incremental printed layers are not compressed in the punch region.", "In some embodiments, one or more incremental printed layers are translated, compressed, marked and/or shaped in the punch region, and one or more incremental layers are not translated, compressed, marked and/or shaped in the punch region.", "The receptacle is movable between the regions (systems) in any order.", "In some embodiments, the receptacle moves: a) from the powder layering region to the binding fluid application region and then to the punch region; b) from the powder layering region to the punch region and then to the binding fluid application region; c) from the powder layering region to the binding fluid application region then back to the powder layering region and then to the punch region; or d) from the powder layering region to the binding fluid application region to the drying region and then to the punch region.", "The discharge region can be placed after the powder layering region, the binding fluid application region, the drying region or the punch region.", "In some aspects, the invention provides a three-dimensional printing equipment assembly/apparatus comprising: a) a three-dimensional printing build system comprising: at least one build module comprising a powder receptacle and a height adjustable platform (or punch) disposed within the receptacle; at least one power layering system for forming a powder layer by depositing powder within the receptacle; at least one binding fluid deposition system for depositing binding fluid to the powder layer to form an incremental printed layer; and at least one punch system for translating, compressing, marking or shaping a powder layer or incremental printed layer within the receptacle.", "The build system can further comprise a layer drying system for in-process drying of an incremental printed layer after formation thereof.", "The equipment assembly/apparatus can further comprise an article drying system for drying of 3DP articles after completion of formation thereof.", "The punch system is used to translate, compress, mark and/or shape at least one in-process incremental printed layer.", "The punch system can be used to create a vertical space in the receptacle for receipt of the next powder layer.", "In some embodiments, the punch system affects a non-compressive vertical translational of the contents of the receptacle.", "In some embodiments, the punch system affects a compression of the contents of the receptacle.", "In other words, punching may or may not cause compression of powder layer(s) and/or incremental layer(s) in the receptacle.", "In some embodiments, punching causes little compression or no compression of the material present in the receptacle (cavity) at the time of tamping, meaning that punching does not compress an incremental layer or a powder layer in the receptacle.", "In some embodiments, the punching step is affected by first dropping the bottom of (the surface of a height adjustable platform within) the receptacle and then lowering a punch into the receptacle.", "Here, the material in the receptacle may or may not be compressed.", "If the distance by which the upper punch is lowered into the receptacle is greater than the distance by which the bottom of the receptacle is lowered, then the material would be compressed.", "If the distance by which the upper punch is lowered into the receptacle is greater than the total of the distance by which the bottom of the receptacle is lowered and the thickness of a powder layer added to (or of the incremental layer within) the receptacle, then the material would be compressed.", "If the distance by which the upper punch is lowered into the receptacle is less than the total of the distance by which the bottom of the receptacle is lowered and the thickness of a powder layer added to (or of the incremental layer within) the receptacle, then the material would not be compressed.", "In some embodiments, the platform (or lower punch) is lowered at the same time as the upper punch.", "In some embodiments, the platform (or lower punch) is lowered after a lag time relative to when the upper punch is lowered.", "In some embodiments, the upper punch is lowered after a lag time relative to when the platform (or lower punch) is lowered.", "In other embodiments, punch step is affected by first lowering the upper punch into the receptacle and then dropping platform in the receptacle, thereby compressing the powder layer or incremental layer in the receptacle.", "In some embodiments, the lag time may be less than 1.0 seconds, or 0.5 seconds, or 0.25 seconds, or 0.1 seconds, or 0.05 seconds.", "Embodiments of the invention include those wherein: a) the equipment assembly (or apparatus) further comprises a conveyor system adapted to conduct plural build modules; b) the conveyor system repeatedly transports the build modules between the at least one powder layering system and the at least one printing system to form at least one article within a build module; c) the equipment assembly further comprises at least one liquid removal system (article drying system) that receives one or more 3DP articles and removes liquid there from; d) the build system further comprises at least one liquid removal system (layer drying system) that removes liquid from one or more incremental layers prior to completion of a build cycle, i.e.", "between formation of incremental layers; e) the conveyor system repeatedly transports the build modules between the at least one powder layering system, the at least one printing system and the at least one punch system to form at least one article within a build module; f) the conveyor system repeatedly transports the build modules between the at least one powder layering system, the at least one printing system, the at least one layer drying system and the at least one punch system to form at least one article within a build module.", "In some embodiments, a build module comprises at least one receptacle (cavity) and an incrementally height adjustable platform (lower punch) disposed therein.", "The receptacle and platform receive and temporarily retain at least one incremental powder layer or plural stacked incremental powder layers.", "In some embodiments, the build module comprises plural receptacles and plural respective incrementally height adjustable platforms (lower punches).", "In some embodiments, a build module comprises a body comprising an upper surface with a cavity, a height adjustable build platform disposed within the cavity, height adjuster engaged with the body and the platform, and engagement means.", "In some embodiments, the platform is adapted to lower (recess) and/or raise by one or more increments before or after formation of an incremental printed layer thereon.", "The platform displacement can occur prior to or after placement of a subsequent incremental layer of powder thereon, thereby press-rolling or removing a portion of powder from a powder layer that has already been laid down.", "In some embodiments, the size of an increment is predetermined.", "In some embodiments, engagement means removably engage a build module with the conveyor system.", "In some embodiments, plural build modules are removably engaged with a conveyor system.", "In some embodiments, the build module comprises one or more sidewalls surrounding the cavity and being adapted to retain powder on the height adjustable platform.", "The system comprises a conveyor that transports one or more build modules along a path through the regions of a 3DP build system.", "In some embodiments, the path is a circuitous path, a horizontal circuitous path, a vertical circuitous path, or a combination thereof.", "In some embodiments, the path is circular, ellipsoidal, oval, rectangular, semicircular, square, triangular, pentagonal, hexagonal, octagon, oval, polygonal, parallelogram, quadrilateral, geometric, symmetrical, asymmetrical, or equivalents thereof with rounded corners and/or edges.", "The conveyor can be a staged conveyor, turret, belt conveyor, wheel conveyor, roller conveyor, chain conveyor, wire mesh conveyor, plate conveyor, slat conveyor, magnetic conveyor, bucket conveyor, cart-on-track conveyor, or other means for conducting solid articles along a process stream.", "The conveyor can be passive or powered.", "The conveyor can be troughed, cleated or flat.", "In some embodiments, the conveyor system is a modular conveyor system comprising plural conveyor modules.", "The conveyor system can comprise at least one drive motor, at least one positioning controller, and a path along which plural build modules are conducted.", "In some embodiments, a conveyor module comprises a body, one or more build module engagement means, and conveyor module engagement means by way of which plural conveyor modules are adapted to engage to form a modular conveyor.", "In some embodiments, the conveyor system comprises plural attachments adapted to removably retain the plural build modules.", "In some embodiments, the attachment comprises plural one or more metal links with cam followers or comprises wheels, plates and/or bearings attached to a build module and mounted on a rail system upon which the build module is conducted.", "In some embodiments, the conveyor system further comprises one or more positioning-controllers.", "In some embodiments, the conveyor system is a continuous or discontinuous loop system.", "In some embodiments, the conveyor and plural build modules are present as a combination.", "In some embodiments, the at least one build station is incrementally height adjustable with respect to the build modules, whereby the vertical space between the build module and the build station can be adjusted by one or more increments.", "In some embodiments, an incrementally height adjustable build station is adapted to raise by one or more increments after placement of a layer of powder on a build module and prior to placement of a subsequent layer of powder the build module.", "In some embodiments, a change in height is achieved by changing vertical position with respect to a prior position of the platform or with respect to an absolute position of the platform relative to the build module.", "In some embodiments, the build station is vertically fixed with respect to the build modules and a build platform within a build module is vertically height adjustable with respect to the build module so that the vertical distance between the build station and the build module remains the same during a print lap or print cycle.", "In some embodiments, the size of the increment is the same for each incremental layer of a build cycle, is different for one or more incremental layers of a build cycle or a combination thereof.", "A build cycle comprises one or more build laps or plural build laps and is defined as the sum total of build laps required to form a 3DP article.", "A build lap is defined as the process of forming a printed incremental layer, i.e.", "placing an incremental layer of powdered build material and depositing (printing) liquid upon it.", "Accordingly, a build cycle results in the formation of plural stacked printed incremental layers that adhere to one another to together form a three-dimensionally printed article.", "In some embodiments, the at least one powder layering system comprises at least one powder fill head.", "In some the embodiments, the powder fill head does not move either longitudinally or transversely with respect to the plane of the upper surface of a build module when applying an incremental layer of powder onto the build module.", "In some embodiments, a powder fill head comprises at least one powder fill head body, at least one powder spreader, and optionally at least one powder-height controller.", "In some embodiments, a powder layering system comprises a powder fill head, at least one powder reservoir and a powder feeder tube adapted to transfer powder from the powder reservoir to the powder fill head.", "In some embodiments, the powder spreader is a cylindrical roller, bar, rod, plate, paddle wheel, slotted wheel, spoked wheel disc, or straight smooth edge.", "In some embodiments, the powder fill head comprises a hopper or chute.", "In some embodiments, the powder spreader is a cylindrical roller the axis of which has or defines a radial direction of motion opposite the linear direction of motion of a build module through the powder layering system.", "In some embodiments, the at least one printing system applies (deposits) liquid to the powder according to a Cartesian coordinate algorithm and/or a polar (radial) coordinate algorithm (cylindrical coordinate system, circular coordinate system, or spherical coordinate system).", "In some embodiments, the printing system comprises at least one print head and at least one liquid feed system.", "A print head can comprise one or more print modules or plural print modules.", "In some embodiments, the invention excludes an equipment assembly or a method wherein the powder fill head moves laterally or transversely or is not stationary, with respect to a build module, while depositing an incremental powder layer.", "In some embodiments, the invention excludes an equipment assembly or a method wherein the print head moves laterally or transversely or is not stationary, with respect to a build module, while applying liquid to an incremental powder layer.", "In some embodiments, both the print head and the powder fill head are stationary during formation of a printed incremental layer or are stationary as otherwise described herein.", "In some embodiments, the at least one printing system applies (deposits) liquid as a three-dimensional pattern of droplets or as plural two-dimensional patterns of droplets defining one or more articles.", "In some embodiments, the pattern comprises droplets placed at equal spacing within one or more articles.", "In some embodiments, this pattern comprises droplets placed at unequal spacing within one or more articles.", "In some embodiments, this pattern comprises droplets with different spacing within different regions of an article.", "In some embodiments, this pattern comprises droplets with tighter spacing (i.e., higher print density) in a region defining the exterior of an article.", "In some embodiments, this pattern comprises droplets with looser spacing (i.e., lower print density) in a region interior to an article.", "In some embodiments, more than one pattern is used.", "In some embodiments, more than one powder (bulk powder) is used.", "In some embodiments, more than one liquid (binding fluid) is used.", "In some embodiments, the liquid comprises a pure solvent, blend of solvents, solution, suspension, colloid, emulsion, melt or a combination thereof.", "The binding fluid can further comprise one or more binders and/or other excipient(s).", "In some embodiments, the equipment assembly further comprises an article transfer system that transfers 3DP articles, one or more at a time, away from the three-dimensional printing build system.", "In some embodiments, the article transfer system transfers 3DP articles to one or more liquid removal systems and/or one or more harvesting systems.", "In some embodiments, the article transfer system is integrated with the conveyor system, the liquid removal system or both.", "In some embodiments, the liquid removal system comprises at least one dryer.", "In some embodiments, the liquid removal system processes one, two or more 3DP articles at a time.", "In some embodiments, the liquid removal system processes one, two or more build modules at a time.", "In some embodiments, the equipment assembly comprises one or more harvesting systems that separates bulk loose powder from one or more 3DP articles.", "In some embodiments, the harvesting system processes articles already processed by the liquid removal system.", "In some embodiments, the harvesting system comprises loose powder collector and three-dimensionally printed article collector.", "In some embodiments, the harvesting system comprises a vibrating or orbiting surface adapted to receive the three-dimensionally printed article(s).", "In some embodiments, the harvesting system comprises a vacuum conveyor with a screen to separate articles from loose powder.", "The vibrating surface can be perforated, non-perforated, corrugated, smooth or non-smooth to permit separation of loose powder from the printed articles.", "Some embodiments of the invention exclude a harvesting system.", "In some embodiments, the equipment assembly further comprises a dedusting system that removes loose particles from printed articles.", "A dedusting system can comprise a housing defining a dedusting region, one or more air jets, e.g.", "one or more air knives, that direct pressurized air into the dedusting region, one or more surfaces or retainers in the dedusting region for temporarily retaining one or more printed articles being dedusted, and one or more outlets through which air and removed particles exit the housing or dedusting region.", "In some embodiments, the equipment assembly further comprises one or more powder recovery systems that collect powder from the one or more systems of the equipment assembly and return it to a powder reservoir.", "The recovery system can comprise one or more loose powder collectors and one or more conduits for conducting loose powder from the one or more collectors to a powder reservoir.", "The recovery system can further comprise: a) one or more powder mixers for mixing recovered loose powder with virgin loose powder; b) one or more pressurized air powder handling systems that facilitate transfer of loose powder from one location to another; c) one or more vacuum powder handling systems that facilitate transfer of loose powder from one location to another; d) one or more mechanical powder handling systems that transfer loose powder from one location to another; e) one or more manual powder handling systems that transfer loose powder from one location to another; or f) a combination thereof.", "In some embodiments, the 3DP equipment assembly excludes a powder recovery system that collects powder from the one or more systems of the equipment assembly and returns it to a powder reservoir.", "In some embodiments, the 3DP equipment assembly excludes a powder recovery system that collects powder from a printed bed comprising plural 3DP articles and loose (unbound, unprinted) powder.", "In some embodiments, the equipment assembly further comprises a control system comprising one or more computerized controllers, one or more computers, and one or more user interfaces for one or more computers.", "In some embodiments, one or more components of the equipment assembly are computer controlled.", "In some embodiments, one or more components of the 3DP build system are computer controlled.", "In some embodiments, the conveyor system, the height adjustable platforms of the build modules, the at least one powder layering system, the at least one punch system, the at least one drying system and/or the at least one printing system are computer controlled.", "In some embodiments, the equipment assembly spreads layers of powder and deposits (print) droplets of liquid in a predetermined pattern on to the layers according to instructions provided by a computerized controller.", "In some embodiments, the predetermined pattern is based on one or more two-dimensional image files comprising pixels.", "In some embodiments, the two-dimensional image files are structured such that certain pixels indicate dispensing of droplets, and other pixels represent no dispensing of droplets.", "In some embodiments, the two-dimensional image files include different colors of pixels to indicate dispensing of different liquids, or no dispensing of liquid.", "In some embodiments, the predetermined pattern for applying the liquid is the same in each incremental layer, is the same in two or more incremental layers, is different in one or more incremental layers, is different in all incremental layers, or is the same for a first group of incremental layer and the same for a second group of incremental layers but the pattern for the first group is different than the pattern for the second group.", "In some embodiments, the equipment assembly further comprises one or more working surfaces, frames, supports, tables, gantries, enclosures, turrets and/or platforms.", "The invention also provides a three-dimensional printing equipment assembly comprising: a) a three-dimensional printing build system comprising: a conveyor system that conducts plural build modules and comprises positioning-controller and plural build module engagements; plural build modules engaged with the conveyor system, wherein the build modules receive and temporarily retain powder from a powder layering system, and wherein a build module comprises: 1) one or more sidewalls defining a cavity; and 2) an incrementally height adjustable platform (punch) disposed within the cavity; at least one build station comprising: 1) at least one powder layering system that forms incremental powder layers within the cavity and comprises at least one powder fill head, at least one powder spreader and at least one powder reservoir; and 2) at least one printing system that applies a liquid according to at least one predetermined pattern to the incremental powder layers and comprises at least one liquid feed system and at least one print head that deposits liquid according to the at least one predetermined pattern; at least one punch system comprising at least one upper punch; wherein the conveyor system repeatedly transports the plural build modules from the at least one powder layering system to the at least one printing system, whereby the three-dimensional printing build system: 1) forms at least one incremental printed layer per build lap in a build module; 2) forms a single 3DP article per build cycle in a build module; 3) forms plural 3DP articles per build cycle in a build module; or 4) forms a 3DP bed comprising one or more three-dimensionally printed articles and, optionally, loose (unbound or only partially bound) powder that has not been printed upon per build cycle in a build module; b) optionally, at least one harvesting system that separates loose powder from: 1) one or more incremental printed layers; 2) one or more 3DP articles; or 3) one or more 3DP beds; and c) optionally, at least one liquid removal system that removes liquid from: 1) one or more incremental printed layers of an in-process incompletely formed 3DP article; 2) one or more 3DP articles after printing thereof; or 3) one or more 3DP beds.", "Some embodiments of the invention include those wherein: 1) at least one liquid removal system is present; 2) the equipment assembly further comprises at least one packaging system that packages one or more three-dimensionally printed articles; 3) the conveyor system repeatedly transports plural build modules from the at least one powder layering system to the at least one printing system in a linear manner thereby facilitating Cartesian coordinate printing or in a radial manner thereby facilitating polar coordinate printing; 4) the equipment assembly further comprises a powder recovery system for recovering, and optionally recycling, unprinted powder; 5) the equipment assembly further comprises a liquid detector; 6) a liquid detector detects the presence of liquid in one or more printed incremental layers and/or in one or more printed articles; 7) the equipment assembly further comprises an inspection system; 8) an inspection system is a printed powder inspection system that determines the integrity of printing in one or more incremental printed layers and/or one or more printed articles and/or determines whether or not powder was properly applied in one or more incremental layers; 9) determining the integrity of printing comprises at least one of determining whether or not liquid has been correctly applied to one or more incremental layers according to one or more predetermined patterns and/or determining whether or not liquid has been correctly applied to one or more incremental layers according to a predetermined amount; 10) the inspection system is a printed article inspection system that determines whether or not one or more printed articles have the correct size, shape, weight, appearance, density, content and/or color; 11) the inspection system is a liquid application inspection system that monitors droplets of liquid applied by the print head to powder; 12) the inspection system comprises one or more cameras; 13) a camera is independently selected at each occurrence from the group consisting of a visible wavelength camera, an UV wavelength camera, a near infrared wavelength camera, an x-ray camera and an infrared wavelength camera; and/or 14) the equipment assembly excludes a powder recovery system for recovering and recycling unprinted powder.", "The invention includes all combinations of the embodiments, subembodiments and aspects disclosed herein.", "Accordingly, the invention includes the embodiments and aspects specifically disclosed, broadly disclosed, or narrowly disclosed herein, as well as combinations thereof and subcombinations of the individual elements of said embodiments and aspects.", "The invention can be a combination of two or more elements described herein or specified in the claims.", "The invention is substantially as described herein.", "In some embodiments, the invention is substantially as described in one or more drawings.", "Other features, advantages and embodiments of the invention will become apparent to those skilled in the art by the following description, accompanying examples." ], [ "CROSS-REFERENCE TO EARLIER FILED APPLICATIONS The present application claims the benefit of and is a continuation of PCT/US2016/047709 filed Aug. 19, 2016, which claims the benefit of provisional applications 62/208,261 filed Aug. 21, 2015 and 62/208,022 filed Aug. 21, 2015, the entire disclosures of which are hereby incorporated by reference.", "FIELD OF THE INVENTION The present invention concerns a manufacturing system and equipment assembly and use thereof for the preparation of articles by cavity three-dimensional printing and for the preparation of articles with variable layer density.", "BACKGROUND OF THE INVENTION Rapid prototyping describes various techniques for fabricating a three-dimensional prototype of an object from a computer model of the object.", "One technique is three-dimensional printing, whereby a printer is used to fabricate the 3-D prototype from a plurality of two-dimensional layers.", "In particular, a digital representation of a 3-D object is stored in a computer memory.", "Computer software sections the representation of the object into a plurality of distinct 2-D layers.", "Alternatively, a stream (sequential series) of instructions for each incremental layer maybe entered directly, e.g.", "a series of images.", "A 3-D printer then fabricates a thin layer of bound material for each 2-D image layer sectioned by the software.", "Together, the layers are printed one on top of the other and adhere to each other to form the desired prototype.", "Three-dimensional powder-liquid printing technology has been used to prepare articles such as pharmaceutical dosage forms, mechanical prototypes and concept models, molds for casting mechanical parts, bone growth promoting implants, electronic circuit boards, scaffolds for tissue engineering, responsive biomedical composites, tissue growth promoting implants, dental restorations, jewelry, fluid filters and other such articles.", "Three-dimensional printing is a solid freeform fabrication technique/rapid-prototyping technique in which thin layers of powder are spread onto a surface and selected regions of the powder are bound together by the controlled deposition (“printing”) of a fluid.", "This basic operation is repeated layer-by-layer, with each new layer formed on top of and adhered to the previously printed layer, to eventually make three-dimensional objects within a bed of unbound powder.", "When the printed objects have sufficient cohesion, they may be separated from the unbound powder.", "Systems and equipment assemblies for three-dimensional printing of articles are commercially available or in use by others: Massachusetts Institute of Technology Three-Dimensional Printing Laboratory (Cambridge, Mass.", "), Z Corporation's 3DP and HD3DP™ systems (Burlington, Mass.", "), The Ex One Company, L.L.C.", "(Irwin, Pa.), Soligen (Northridge, Calif.), Specific Surface Corporation (Franklin, Mass.", "), TDK Corporation (Chiba-ken, Japan), Therics L.L.C.", "(Akron, Ohio, now a part of Integra Lifesciences), Phoenix Analysis & Design Technologies (Tempe, Ariz.), Stratasys, Inc.'s Dimension™ system (Eden Prairie, Minn.), Objet Geometries (Billerica, Mass.", "or Rehovot, Israel), Xpress3D (Minneapolis, Minn.), and 3D Systems' Invision™ system (Valencia, Calif.).", "Some systems have been described in the patent literature: U.S. Publications No.", "20080281019, No.", "20080277823, No.", "20080275181, No.", "20080269940, No.", "20080269939, No.", "20080259434, No.", "20080241404, No.", "20080231645, No.", "20080229961, No.", "20080211132, No.", "20080192074, No.", "20080187711, No.", "20080180509, No.", "20080138515, No.", "20080124464, No.", "20080121172, No.", "20080121130, No.", "20080118655, No.", "20080110395, No.", "20080105144, No.", "20080068416, No.", "20080062214, No.", "20080042321, No.", "20070289705, No.", "20070259010, No.", "20070252871, No.", "20070195150, No.", "20070188549, No.", "20070187508, No.", "20070182799, No.", "20070182782, No.", "20070168815, No.", "20070146734, No.", "20060268057, No.", "20060268044, No.", "20060230970, No.", "20060141145, No.", "20060127153, No.", "20060111807, No.", "20060110443, No.", "20060099287, No.", "20060077241, No.", "20050054039, No.", "20060035034, No.", "20060030964, No.", "20050247216, No.", "20050204939, No.", "20050197431, No.", "20050179721, No.", "20050104241, No.", "20050069784, No.", "20050061241, No.", "20050059757, No.", "20040265413, No.", "20040262797, No.", "20040252174, No.", "20040243133, No.", "20040225398, No.", "20040187714, No.", "20040183796, No.", "20040145781, No.", "20040145628, No.", "20040145267, No.", "20040143359, No.", "20040141043, No.", "20040141030, No.", "20040141025, No.", "20040141024, No.", "20040118309, No.", "20040112523, No.", "20040056378, No.", "20040012112, No.", "20040005360, No.", "20040005182, No.", "20040004653, No.", "20040004303, No.", "20040003741, No.", "20040003738, No.", "20030207959, No.", "20030198677, No.", "20030143268, No.", "20020125592, No.", "20020114652, No.", "20020079601, No.", "20020064745, No.", "20020033548, No.", "20020015728, No.", "20010028471, and No.", "20010017085; U.S. Pat.", "No.", "5,490,962, No.", "5,204,055, No.", "5,121,329, No.", "5,127,037, No.", "5,252,264, No.", "5,340,656, Nos.", "5,387,380, 5,490,882, No.", "5,518,680, No.", "5,717,599, No.", "5,851,465, No.", "5,869,170, No.", "5,874,279, No.", "5,879,489, No.", "5,902,441, No.", "5,934,343, No.", "5,940,674, No.", "6,007,318, No.", "6,146,567, No.", "6,165,406, No.", "6,193,923, No.", "6,200,508, No.", "6,213,168, No.", "6,336,480, No.", "6,363,606, No.", "6,375,874, No.", "6,416,850, No.", "6,508,971, No.", "6,530,958, No.", "6,547,994, No.", "6,596,224, No.", "6,772,026, No.", "6,838,035, No.", "6,850,334, No.", "6,905,645, No.", "6,945,638, No.", "6,989,115, No.", "7,220,380, No.", "7,291,002 No.", "7,365,129, No.", "7,435,368, No.", "7,455,804, No.", "7,686,955, No.", "7,828,022, No.", "8,017,055, No.", "8,888,480; PCT International Publications No.", "WO 00/26026, No.", "WO 98/043762, No.", "WO 95/034468, No.", "WO 95/011007, No.", "WO 2014/039378; and European Patent No.", "1,631,440, which employs a cylindrical (radial or polar) coordinate-based system due to its construction.", "Three-dimensional printing systems employing powder and binding fluid typically form articles by placing layers of powder within a receptacle and depositing binding fluid on the individual layers of powder.", "The binding fluid is applied in patterns to regions of the powder in each layer such that unbound powdered material remains on the outer periphery of the patterns.", "The printed articles, which comprise bound powder, are then separated from substantial amounts of unbound powder.", "Such processes undesirably require wasting or recycling the unbound powder.", "It would be a substantial improvement in the field to provide an equipment assembly, system and method for substantially reducing or eliminating the need to waste or recycle unbound powder.", "Three-dimensional printing systems have most often been directed to the manufacturing of custom or “one-off” parts, or in some cases toward mass customization.", "This may include fabrication of many different parts exhibiting different sizes and shapes from one another, either in a series of separate build cycles or in some cases within different processing regions of the same build cycle.", "The goal of flexibility and customization without tooling has led many of these systems to use large open beds, which further contribute to potential issues of waste or recycling of unbound powder when dealing with powder-liquid three-dimensional printing.", "These systems are not as well suited to the manufacturing of large numbers of identical parts, and it would be a substantial improvement in the field to provide an equipment assembly, system and method that is amenable to manufacturing of large numbers of identical parts while reducing or eliminating the need to waste or recycle unbound powder.", "To date, there has been no disclosure of a system employing any type of compression during formation (during the print cycle of the process) of a three-dimensionally printed article.", "The only types of compression for 3DP articles have been cold isostatic pressing or uniaxial compression, in each case after formation of the article, meaning after the print cycle and drying cycle have been completed.", "Uniaxially compressed three-dimensionally printed dosage forms are known (U.S. Pat.", "No.", "7,931,914, U.S. Pat.", "No.", "8,758,658 and WO 2003/037607, which overcome certain disadvantages cited for cold isostatic pressing).", "They are made by first completing the three-dimensional printing part of the process, drying the dosage form and then uniaxially compressing the dosage form.", "If cold isostatic compression is used, a temporary elastomeric bag or mold is required for each article to be immersed in a confined liquid used to apply the pressure uniformly to all surfaces, after which the bag or mold is removed.", "In either case, such a system and process does not allow for the formation of three-dimensionally printed articles having controlled and varying void fraction among the individual layers of the printed articles, because compression is performed on the entire printed article.", "Such a system and process cannot form a three-dimensionally printed article comprising a more tightly compressed lower region (a higher density portion) and a more loosely compressed or even uncompressed upper region (a lower density portion).", "It would be a substantial improvement in the field to provide an equipment assembly, system and method for the preparation of three-dimensionally printed articles comprising upper and lower portions differing in density (or void fraction).", "SUMMARY OF THE INVENTION The present invention provides a manufacturing system and equipment assembly useful for the preparation of articles by three-dimensional printing.", "The system and assembly can be used for high through-put continuous, semi-continuous, or batch manufacture with minimal product loss, high efficiency, and high product reproducibility in the context of flexible article design.", "The invention can provide a substantial reduction in or elimination of waste unbound powder as compared to other three-dimensional printing (3DP) processes.", "Cavity 3DP provides for most, substantially all or all of the solid material entering each cavity to be incorporated into a corresponding single 3DP article.", "The term cavity refers to the receptacle which receives the solid material.", "The receptacle can be part of a build module.", "In some embodiments, powdered solid material and liquid material are combined to form the article in the cavity.", "In some aspects, the invention provides a three-dimensional printing equipment assembly (or apparatus) comprising: a) a three-dimensional printing build system comprising: at least one powder layering region (or system); at least one binding fluid application region (or system); and at least one powder receptacle movable between the regions, wherein the inner periphery of a top plan view of the powder receptacle approximates the outer periphery of a plan view of an article to be prepared with the build system.", "Embodiments of the invention include those wherein: a) the equipment assembly comprises plural powder receptacles; b) the powder receptacles are arranged sequentially with respect to their direction of approach to the powder layering system; c) the powder receptacle is part of a build module; and/or d) a height adjustable platform is disposed within the receptacle.", "In some aspects, the invention provides a three-dimensional printing equipment assembly (or apparatus) comprising: a) a three-dimensional printing build system comprising: at least one build module comprising at least one receptacle (cavity) that receives and temporarily retains powder from a powder layering system, wherein the receptacle has a top plan view periphery that approximates the periphery of a plan view of an article to be prepared with the equipment assembly; and at least one build station comprising: 1) at least one powder layering system that deposits powder within the receptacle; and 2) at least one printing system that applies binding fluid at least to the periphery of powder layer(s) within proximity of the periphery of the receptacle.", "In some embodiments, the equipment assembly (or apparatus) further comprises: a) a liquid removal system; b) a 3DP article dedusting system; c) a packaging system; e) a punch system; f) a punch system comprising at least one upper punch and at least one lower punch; g) a punch system comprising an upper punch having a bottom plan view with a periphery approximating the periphery of the receptacle; h) a lower punch having a top plan view with a periphery approximating the periphery of the receptacle; i) the punch further comprises a seal between the punch and the inner surface of the receptacle; j) a height adjustable platform in the receptacle and an upper punch; k) a height adjustable platform in the receptacle; l) a height adjustable platform in the receptacle, wherein the periphery of a top plan view of the platform approximates the inner periphery of the receptacle; m) an air relief means to release displaced air or equalize air pressure when an upper punch enters a cavity; n) a servo motor control on the upper punch, lower punch, or both; o) a positioning system on the upper punch, lower punch, or b both, in each case comprising a ball screw characterized by a lead accuracy V300p value that is less than or equal to about 50 microns, or less than or equal to about 20 microns, or less than or equal to about 10 microns, or less than or equal to about 5 microns.", "In some embodiments, the periphery of the receptacle approximates the periphery of a plan view of a single article to be prepared.", "The periphery of the receptacle, the upper punch and the height adjustable platform approximates the periphery of a plan view of a single article to be prepared.", "The invention also includes embodiments wherein: a) the receptacle has a top-plan view surface area approximating (within 20%, within 15%, within 10%, within 5%, within 1% or within 0.5% of) or the same as the plan view surface area of the article to be prepared; b) the receptacle has a top-plan view approximating or the same as a plan view of the article to be prepared; and/or c) the receptacle has a top-plan view periphery approximating or the same as a plan view periphery of the article to be prepared.", "In some embodiments, the weight percentage of powder entering each cavity that is incorporated into a corresponding single final article is >80%, >90%, >95%, >98%, >99% or 100%.", "In some embodiments, the process is a zero-waste process in that solid material is neither recycled nor disposed of following completion of a build cycle.", "During a 3DP build cycle using a cavity 3DP apparatus or equipment assembly, a layer of powder is placed within the cavity (receptacle), droplets of binding fluid are applied at or near the periphery of the powder to form an incremental layer having a top-plan view approximating the periphery of the cavity.", "A drying step is optionally conducted following the application step prior to placing another layer of powder in the cavity.", "Steps of the process are repeated to form plural incremental layers within the cavity.", "Following completion of the build cycle, the 3DP article is discharged from the cavity.", "The 3DP article is optionally dried, optionally dedusted, and/or optionally packaged.", "In some aspects, the invention provides a method of preparing a three-dimensionally printed article, the method comprising: forming a layer of powder within a receptacle, wherein the inner periphery of a top plan view of the receptacle approximates the outer periphery of a plan view of the article; depositing binding fluid at or near the periphery of the powder layer within the receptacle to form an incremental layer defined by a print pattern, the outer periphery of which has a top-plan view approximating the inner periphery of the cavity.", "Embodiments of the invention include those wherein: a) the process further comprises providing a receptacle, the top plan view of which is defined by an inner periphery that approximates the outer periphery of a plan view of the article; b) the process further comprises depositing binding fluid to the powder within the region defined by the print pattern; c) the powder has an average particle size, and the outer periphery of the print pattern in an incremental layer is spaced away from the inner periphery of the receptacle a distance that is 0.1, 0.5, 1, 2, 5, or 10-fold of the average particle size, or is selected from the ranges of 0.1- to 1-fold, 0.5 to 2-fold, 1- to 5-fold, or 5- to 10-fold of the average particle size; d) after the step of depositing, the incremental layer comprises a band of powder (unprinted powder, loose powder, unbound powder) that is 0.1, 0.5, 1, 2, 5, or 10-fold of the average particle size, or is selected from the ranges of 0.1- to 1-fold, 0.5 to 2-fold, 1- to 5-fold, or 5- to 10-fold of the average particle size, with the band situated between the inner periphery of the receptacle and the outer periphery of the print pattern; e) the forming and depositing steps are repeated to form the 3DP article; f) the outer periphery of print pattern in an incremental layer encloses an area comprising printed powder, unprinted powder or a combination thereof; f) the plan view of the article is a side plan view, top plan view, bottom plan view or a silhouette of a perspective view of the article; g) the outer periphery of the print pattern of an incremental layer is adjacent the inner periphery of the receptacle; h) a combination of any of the above.", "In some embodiments: a) the periphery of the receptacle (cavity) is not shaped as a square, or rectangle, or star (e.g., 5-pointed star), or other shape with a plurality of sharp, thin edges, corners, or protrusions that extend away from the center of receptacle (cavity); b) the periphery of the receptacle comprises a geometric shape, non-geometric shape or combination thereof; c) a single article is formed within each receptacle; d) the print pattern is for an incremental layer of a single article; e) no unprinted (unbound) powder remains in the receptacle; f) unprinted powder remains within the area of an incremental layer defined by the outer periphery of the print pattern; g) one or more incremental layers are formed by depositing binding fluid more than once to a layer of powder; h) the rate of application or deposition (mL/cm2 or mL/min or mL/sec) of binding fluid is the same across all incremental layers; i) the rate of application or deposition of binding fluid is different between at least two incremental layers of a 3DP article; j) each incremental layer is formed by depositing binding fluid only once to its respective layer of powder; k) one or more cavities can be characterized as have a longest linear dimension, and the longest linear dimension of a cavity, or of each cavity, is less than or equal to 12 inches, 6 inches, 3 inches, 2 inches, or 1 inch in length; l) the cavities are housed within, or defined by, or housed within and defined by openings within a turret member; m) the process is characterized by continuous motion of one or more cavities during the spreading and printing steps; n) the process is characterized by stopping of one or more cavities to allow for optional translating, compressing, marking or shaping the one or more incremental printed layers using the upper punch.", "In some aspects, the invention provides a method of preparing a three-dimensionally printed article, the method comprising: a) forming one or more layers of powder within a receptacle comprising a lower height adjustable platform (or punch), wherein the inner periphery of a top plan view of the receptacle and the outer periphery of a top plan view of the platform (or punch) approximates the outer periphery of a plan view of the article; b) depositing binding fluid at or near the periphery of the one or more powder layers within the receptacle to form one or more incremental printed layers defined by a print pattern, the outer periphery of which has a top-plan view approximating the inner periphery of the receptacle; c) before completion of the 3DP article, translating, compressing, marking or shaping the one or more incremental printed layers in the receptacle with a punch system; and d) repeating steps a) and b), and optionally step c), to complete formation of the 3DP article.", "In some aspects, the invention provides a method of preparing a three-dimensionally printed article, the method comprising: a) forming one or more layers of powder within a receptacle comprising a lower height adjustable platform (or punch); b) according to a print pattern, depositing binding fluid onto the one or more powder layers to form a printed bed comprising loose unprinted powder and one or more incremental printed layers corresponding to one or more 3DP articles; c) before completion of the one or more 3DP articles, translating, compressing, marking or shaping the one or more incremental printed layers in the receptacle with a punch system; and d) repeating steps a) and b), and optionally step c), to complete formation of the one or more 3DP articles.", "Some embodiments of the invention include those wherein: 1) an additional step c) is performed between steps a) and b); 2) step c) is performed before step b); 3) the process further comprises a drying step after step b), such that the amount of binding fluid in the one or more incremental printed layers is reduced prior to conducting step c); 4) steps a) and b) are repeated and step c) is conducted at least once during preparation of a 3DP article; 5) steps a), b) and c) are each repeated at least once during preparation of a 3DP article; 6) the minimal sequence of steps in the process is: i) step a), step b), drying, step c) and step d); ii) step a), step c), step b), drying, step c), and step d); and/or 7) step c) is performed while the receptacle is stationary.", "The punch system can comprise an upper punch disposed above the height adjustable platform (or above a lower punch) such that the incremental printed layer(s) is(are) between the two.", "The translating step can be conducted by lowering the platform the same (or approximately or about the same) vertical distance as the upper punch.", "The compressing step can be conducted by: a) lowering the platform a first vertical distance and lowering the upper punch a second vertical distance, which is greater than the first vertical distance; b) first, lowering the upper punch and second lowering the platform; c) maintaining the upper punch at a position and raising the platform; d) lowering the upper punch and raising the platform; or e) first, raising the platform and second raising the upper punch.", "The invention also provides three-dimensionally printed (3DP) articles having regions (comprising one or more incremental printed layers) that differ in void fraction (density), wherein at least one region has been compressed and another region has not been compressed.", "The 3DP article comprises plural incremental printed layers, wherein at least one incremental printed layer is compressed.", "In some embodiments, the 3DP article comprises plural incremental printed layers, wherein at least one incremental printed layer is a compressed layer and at least one incremental printed layer is an uncompressed (non-compressed) layer.", "The compressed layer can have a lower void fraction and higher density than the uncompressed layer.", "In some embodiments, the 3DP article comprises plural compressed incremental printed layers and at least one uncompressed incremental printed layer.", "In some embodiments, the 3DP article comprises plural compressed incremental printed layers and plural uncompressed incremental printed layers.", "In some embodiments, the compressed layer is uniformly compressed, and in some embodiments the layer is non-uniformly compressed.", "The invention provides a 3DP article comprising at least one uniformly compressed incremental layer and at least one non-uniformly compressed incremental layer.", "In some embodiments, the invention excludes a 3DP article that has been compressed solely by uniaxial compression following completion of a build cycle (formation of all incremental layers) or following drying of the article.", "The at least one compressed incremental printed layer is formed during a build lap before completion of a build cycle.", "The invention provides a process, equipment assembly/apparatus for preparing a 3DP article comprising at least one compressed, marked or shaped incremental printed layer.", "The process comprises compressing, marking and/or shaping one or more incremental printed layers during formation (during the build cycle) of the 3DP article.", "A 3DP article comprising at least one compressed, marked and/or shaped region can be made by a process comprising: a) forming an incremental printed layer; and b) compressing, marking and/or shaping the incremental printed layer with a punch system prior to completion of formation (printing) of the 3DP article.", "The process can further comprise: forming another incremental printed layer before step a) or after step b).", "In some embodiments, the compressing, marking and/or shaping step is conducted on each incremental printed layer of a 3DP article or on at least one but less than all of the incremental printed layers of a 3DP article.", "The invention also includes a three-dimensionally printed (3DP) article comprising at least two incremental printed layers, wherein: at least one printed incremental layer comprises a first region and a horizontally adjacent second region; the first region is prepared from a first bulk powder and first binding fluid; the second region is prepared from a second bulk powder and second binding fluid; and the first bulk powder is different from the second bulk powder.", "The first binding fluid and the second binding fluid can be the same or different.", "The first binding fluid and the second binding fluid can have different compositions.", "The first bulk powder and the second bulk powder can have the same or different compositions.", "In some embodiments, the process comprises: forming a powder layer in a cavity; depositing or printing liquid onto the powder layer in the cavity to form an incremental printed layer; and translating, compressing, marking and/or shaping the powder layer and/or incremental printed layer.", "In some embodiments, the process comprises: forming a powder layer in a cavity; depositing or printing liquid onto the powder layer in the cavity to form a incremental printed layer; forming another powder layer in the cavity; and simultaneously translating, compressing, marking and/or shaping the powder layer and incremental printed layer.", "The process can further comprise drying the incremental printed layer before or after translating, compressing, marking and/or shaping.", "The steps are repeated as needed to form a 3DP article comprising a full complement of incremental printed layers required to complete its structure.", "In some embodiments, the invention excludes a process wherein a three-dimensionally printed article has been compressed solely by uniaxial compression following completion of a build cycle, following completion of formation (printing) of the article or following drying of the article.", "The invention also provides a 3DP equipment assembly (or apparatus) and process for translating, compressing, marking and/or shaping one or more incremental layers after formation thereof but before completion of a build cycle, which forms one or more 3DP articles.", "In some aspects, the 3DP equipment assembly (or apparatus) comprises: at least one powder layering region (or system); at least one binding fluid application region (or system); at least one punch region (or system); and at least one powder receptacle movable between the regions.", "The equipment assembly (or apparatus) can further comprise a drying region (or system) and a discharge (article transfer) region (or system).", "The powder receptacle receives a powder when in the powder layering region to form a powder layer in the receptacle.", "Binding fluid is applied to the powder layer when the receptacle is in the binding fluid application region to form an incremental printed layer in the receptacle.", "Material (either powder layer or incremental printed layer) in the receptacle is punched in the punch region, wherein the punching may result in translating, compressing, marking and/or shaping of the powder layer or incremental printed layer depending upon how the punch is conducted.", "In some embodiments, one or more incremental printed layers are translated, compressed, marked and/or shaped in the punch region.", "In some embodiments, one or more incremental printed layers are not compressed in the punch region.", "In some embodiments, one or more incremental printed layers are translated, compressed, marked and/or shaped in the punch region, and one or more incremental layers are not translated, compressed, marked and/or shaped in the punch region.", "The receptacle is movable between the regions (systems) in any order.", "In some embodiments, the receptacle moves: a) from the powder layering region to the binding fluid application region and then to the punch region; b) from the powder layering region to the punch region and then to the binding fluid application region; c) from the powder layering region to the binding fluid application region then back to the powder layering region and then to the punch region; or d) from the powder layering region to the binding fluid application region to the drying region and then to the punch region.", "The discharge region can be placed after the powder layering region, the binding fluid application region, the drying region or the punch region.", "In some aspects, the invention provides a three-dimensional printing equipment assembly/apparatus comprising: a) a three-dimensional printing build system comprising: at least one build module comprising a powder receptacle and a height adjustable platform (or punch) disposed within the receptacle; at least one power layering system for forming a powder layer by depositing powder within the receptacle; at least one binding fluid deposition system for depositing binding fluid to the powder layer to form an incremental printed layer; and at least one punch system for translating, compressing, marking or shaping a powder layer or incremental printed layer within the receptacle.", "The build system can further comprise a layer drying system for in-process drying of an incremental printed layer after formation thereof.", "The equipment assembly/apparatus can further comprise an article drying system for drying of 3DP articles after completion of formation thereof.", "The punch system is used to translate, compress, mark and/or shape at least one in-process incremental printed layer.", "The punch system can be used to create a vertical space in the receptacle for receipt of the next powder layer.", "In some embodiments, the punch system affects a non-compressive vertical translational of the contents of the receptacle.", "In some embodiments, the punch system affects a compression of the contents of the receptacle.", "In other words, punching may or may not cause compression of powder layer(s) and/or incremental layer(s) in the receptacle.", "In some embodiments, punching causes little compression or no compression of the material present in the receptacle (cavity) at the time of tamping, meaning that punching does not compress an incremental layer or a powder layer in the receptacle.", "In some embodiments, the punching step is affected by first dropping the bottom of (the surface of a height adjustable platform within) the receptacle and then lowering a punch into the receptacle.", "Here, the material in the receptacle may or may not be compressed.", "If the distance by which the upper punch is lowered into the receptacle is greater than the distance by which the bottom of the receptacle is lowered, then the material would be compressed.", "If the distance by which the upper punch is lowered into the receptacle is greater than the total of the distance by which the bottom of the receptacle is lowered and the thickness of a powder layer added to (or of the incremental layer within) the receptacle, then the material would be compressed.", "If the distance by which the upper punch is lowered into the receptacle is less than the total of the distance by which the bottom of the receptacle is lowered and the thickness of a powder layer added to (or of the incremental layer within) the receptacle, then the material would not be compressed.", "In some embodiments, the platform (or lower punch) is lowered at the same time as the upper punch.", "In some embodiments, the platform (or lower punch) is lowered after a lag time relative to when the upper punch is lowered.", "In some embodiments, the upper punch is lowered after a lag time relative to when the platform (or lower punch) is lowered.", "In other embodiments, punch step is affected by first lowering the upper punch into the receptacle and then dropping platform in the receptacle, thereby compressing the powder layer or incremental layer in the receptacle.", "In some embodiments, the lag time may be less than 1.0 seconds, or 0.5 seconds, or 0.25 seconds, or 0.1 seconds, or 0.05 seconds.", "Embodiments of the invention include those wherein: a) the equipment assembly (or apparatus) further comprises a conveyor system adapted to conduct plural build modules; b) the conveyor system repeatedly transports the build modules between the at least one powder layering system and the at least one printing system to form at least one article within a build module; c) the equipment assembly further comprises at least one liquid removal system (article drying system) that receives one or more 3DP articles and removes liquid there from; d) the build system further comprises at least one liquid removal system (layer drying system) that removes liquid from one or more incremental layers prior to completion of a build cycle, i.e.", "between formation of incremental layers; e) the conveyor system repeatedly transports the build modules between the at least one powder layering system, the at least one printing system and the at least one punch system to form at least one article within a build module; f) the conveyor system repeatedly transports the build modules between the at least one powder layering system, the at least one printing system, the at least one layer drying system and the at least one punch system to form at least one article within a build module.", "In some embodiments, a build module comprises at least one receptacle (cavity) and an incrementally height adjustable platform (lower punch) disposed therein.", "The receptacle and platform receive and temporarily retain at least one incremental powder layer or plural stacked incremental powder layers.", "In some embodiments, the build module comprises plural receptacles and plural respective incrementally height adjustable platforms (lower punches).", "In some embodiments, a build module comprises a body comprising an upper surface with a cavity, a height adjustable build platform disposed within the cavity, height adjuster engaged with the body and the platform, and engagement means.", "In some embodiments, the platform is adapted to lower (recess) and/or raise by one or more increments before or after formation of an incremental printed layer thereon.", "The platform displacement can occur prior to or after placement of a subsequent incremental layer of powder thereon, thereby press-rolling or removing a portion of powder from a powder layer that has already been laid down.", "In some embodiments, the size of an increment is predetermined.", "In some embodiments, engagement means removably engage a build module with the conveyor system.", "In some embodiments, plural build modules are removably engaged with a conveyor system.", "In some embodiments, the build module comprises one or more sidewalls surrounding the cavity and being adapted to retain powder on the height adjustable platform.", "The system comprises a conveyor that transports one or more build modules along a path through the regions of a 3DP build system.", "In some embodiments, the path is a circuitous path, a horizontal circuitous path, a vertical circuitous path, or a combination thereof.", "In some embodiments, the path is circular, ellipsoidal, oval, rectangular, semicircular, square, triangular, pentagonal, hexagonal, octagon, oval, polygonal, parallelogram, quadrilateral, geometric, symmetrical, asymmetrical, or equivalents thereof with rounded corners and/or edges.", "The conveyor can be a staged conveyor, turret, belt conveyor, wheel conveyor, roller conveyor, chain conveyor, wire mesh conveyor, plate conveyor, slat conveyor, magnetic conveyor, bucket conveyor, cart-on-track conveyor, or other means for conducting solid articles along a process stream.", "The conveyor can be passive or powered.", "The conveyor can be troughed, cleated or flat.", "In some embodiments, the conveyor system is a modular conveyor system comprising plural conveyor modules.", "The conveyor system can comprise at least one drive motor, at least one positioning controller, and a path along which plural build modules are conducted.", "In some embodiments, a conveyor module comprises a body, one or more build module engagement means, and conveyor module engagement means by way of which plural conveyor modules are adapted to engage to form a modular conveyor.", "In some embodiments, the conveyor system comprises plural attachments adapted to removably retain the plural build modules.", "In some embodiments, the attachment comprises plural one or more metal links with cam followers or comprises wheels, plates and/or bearings attached to a build module and mounted on a rail system upon which the build module is conducted.", "In some embodiments, the conveyor system further comprises one or more positioning-controllers.", "In some embodiments, the conveyor system is a continuous or discontinuous loop system.", "In some embodiments, the conveyor and plural build modules are present as a combination.", "In some embodiments, the at least one build station is incrementally height adjustable with respect to the build modules, whereby the vertical space between the build module and the build station can be adjusted by one or more increments.", "In some embodiments, an incrementally height adjustable build station is adapted to raise by one or more increments after placement of a layer of powder on a build module and prior to placement of a subsequent layer of powder the build module.", "In some embodiments, a change in height is achieved by changing vertical position with respect to a prior position of the platform or with respect to an absolute position of the platform relative to the build module.", "In some embodiments, the build station is vertically fixed with respect to the build modules and a build platform within a build module is vertically height adjustable with respect to the build module so that the vertical distance between the build station and the build module remains the same during a print lap or print cycle.", "In some embodiments, the size of the increment is the same for each incremental layer of a build cycle, is different for one or more incremental layers of a build cycle or a combination thereof.", "A build cycle comprises one or more build laps or plural build laps and is defined as the sum total of build laps required to form a 3DP article.", "A build lap is defined as the process of forming a printed incremental layer, i.e.", "placing an incremental layer of powdered build material and depositing (printing) liquid upon it.", "Accordingly, a build cycle results in the formation of plural stacked printed incremental layers that adhere to one another to together form a three-dimensionally printed article.", "In some embodiments, the at least one powder layering system comprises at least one powder fill head.", "In some the embodiments, the powder fill head does not move either longitudinally or transversely with respect to the plane of the upper surface of a build module when applying an incremental layer of powder onto the build module.", "In some embodiments, a powder fill head comprises at least one powder fill head body, at least one powder spreader, and optionally at least one powder-height controller.", "In some embodiments, a powder layering system comprises a powder fill head, at least one powder reservoir and a powder feeder tube adapted to transfer powder from the powder reservoir to the powder fill head.", "In some embodiments, the powder spreader is a cylindrical roller, bar, rod, plate, paddle wheel, slotted wheel, spoked wheel disc, or straight smooth edge.", "In some embodiments, the powder fill head comprises a hopper or chute.", "In some embodiments, the powder spreader is a cylindrical roller the axis of which has or defines a radial direction of motion opposite the linear direction of motion of a build module through the powder layering system.", "In some embodiments, the at least one printing system applies (deposits) liquid to the powder according to a Cartesian coordinate algorithm and/or a polar (radial) coordinate algorithm (cylindrical coordinate system, circular coordinate system, or spherical coordinate system).", "In some embodiments, the printing system comprises at least one print head and at least one liquid feed system.", "A print head can comprise one or more print modules or plural print modules.", "In some embodiments, the invention excludes an equipment assembly or a method wherein the powder fill head moves laterally or transversely or is not stationary, with respect to a build module, while depositing an incremental powder layer.", "In some embodiments, the invention excludes an equipment assembly or a method wherein the print head moves laterally or transversely or is not stationary, with respect to a build module, while applying liquid to an incremental powder layer.", "In some embodiments, both the print head and the powder fill head are stationary during formation of a printed incremental layer or are stationary as otherwise described herein.", "In some embodiments, the at least one printing system applies (deposits) liquid as a three-dimensional pattern of droplets or as plural two-dimensional patterns of droplets defining one or more articles.", "In some embodiments, the pattern comprises droplets placed at equal spacing within one or more articles.", "In some embodiments, this pattern comprises droplets placed at unequal spacing within one or more articles.", "In some embodiments, this pattern comprises droplets with different spacing within different regions of an article.", "In some embodiments, this pattern comprises droplets with tighter spacing (i.e., higher print density) in a region defining the exterior of an article.", "In some embodiments, this pattern comprises droplets with looser spacing (i.e., lower print density) in a region interior to an article.", "In some embodiments, more than one pattern is used.", "In some embodiments, more than one powder (bulk powder) is used.", "In some embodiments, more than one liquid (binding fluid) is used.", "In some embodiments, the liquid comprises a pure solvent, blend of solvents, solution, suspension, colloid, emulsion, melt or a combination thereof.", "The binding fluid can further comprise one or more binders and/or other excipient(s).", "In some embodiments, the equipment assembly further comprises an article transfer system that transfers 3DP articles, one or more at a time, away from the three-dimensional printing build system.", "In some embodiments, the article transfer system transfers 3DP articles to one or more liquid removal systems and/or one or more harvesting systems.", "In some embodiments, the article transfer system is integrated with the conveyor system, the liquid removal system or both.", "In some embodiments, the liquid removal system comprises at least one dryer.", "In some embodiments, the liquid removal system processes one, two or more 3DP articles at a time.", "In some embodiments, the liquid removal system processes one, two or more build modules at a time.", "In some embodiments, the equipment assembly comprises one or more harvesting systems that separates bulk loose powder from one or more 3DP articles.", "In some embodiments, the harvesting system processes articles already processed by the liquid removal system.", "In some embodiments, the harvesting system comprises loose powder collector and three-dimensionally printed article collector.", "In some embodiments, the harvesting system comprises a vibrating or orbiting surface adapted to receive the three-dimensionally printed article(s).", "In some embodiments, the harvesting system comprises a vacuum conveyor with a screen to separate articles from loose powder.", "The vibrating surface can be perforated, non-perforated, corrugated, smooth or non-smooth to permit separation of loose powder from the printed articles.", "Some embodiments of the invention exclude a harvesting system.", "In some embodiments, the equipment assembly further comprises a dedusting system that removes loose particles from printed articles.", "A dedusting system can comprise a housing defining a dedusting region, one or more air jets, e.g.", "one or more air knives, that direct pressurized air into the dedusting region, one or more surfaces or retainers in the dedusting region for temporarily retaining one or more printed articles being dedusted, and one or more outlets through which air and removed particles exit the housing or dedusting region.", "In some embodiments, the equipment assembly further comprises one or more powder recovery systems that collect powder from the one or more systems of the equipment assembly and return it to a powder reservoir.", "The recovery system can comprise one or more loose powder collectors and one or more conduits for conducting loose powder from the one or more collectors to a powder reservoir.", "The recovery system can further comprise: a) one or more powder mixers for mixing recovered loose powder with virgin loose powder; b) one or more pressurized air powder handling systems that facilitate transfer of loose powder from one location to another; c) one or more vacuum powder handling systems that facilitate transfer of loose powder from one location to another; d) one or more mechanical powder handling systems that transfer loose powder from one location to another; e) one or more manual powder handling systems that transfer loose powder from one location to another; or f) a combination thereof.", "In some embodiments, the 3DP equipment assembly excludes a powder recovery system that collects powder from the one or more systems of the equipment assembly and returns it to a powder reservoir.", "In some embodiments, the 3DP equipment assembly excludes a powder recovery system that collects powder from a printed bed comprising plural 3DP articles and loose (unbound, unprinted) powder.", "In some embodiments, the equipment assembly further comprises a control system comprising one or more computerized controllers, one or more computers, and one or more user interfaces for one or more computers.", "In some embodiments, one or more components of the equipment assembly are computer controlled.", "In some embodiments, one or more components of the 3DP build system are computer controlled.", "In some embodiments, the conveyor system, the height adjustable platforms of the build modules, the at least one powder layering system, the at least one punch system, the at least one drying system and/or the at least one printing system are computer controlled.", "In some embodiments, the equipment assembly spreads layers of powder and deposits (print) droplets of liquid in a predetermined pattern on to the layers according to instructions provided by a computerized controller.", "In some embodiments, the predetermined pattern is based on one or more two-dimensional image files comprising pixels.", "In some embodiments, the two-dimensional image files are structured such that certain pixels indicate dispensing of droplets, and other pixels represent no dispensing of droplets.", "In some embodiments, the two-dimensional image files include different colors of pixels to indicate dispensing of different liquids, or no dispensing of liquid.", "In some embodiments, the predetermined pattern for applying the liquid is the same in each incremental layer, is the same in two or more incremental layers, is different in one or more incremental layers, is different in all incremental layers, or is the same for a first group of incremental layer and the same for a second group of incremental layers but the pattern for the first group is different than the pattern for the second group.", "In some embodiments, the equipment assembly further comprises one or more working surfaces, frames, supports, tables, gantries, enclosures, turrets and/or platforms.", "The invention also provides a three-dimensional printing equipment assembly comprising: a) a three-dimensional printing build system comprising: a conveyor system that conducts plural build modules and comprises positioning-controller and plural build module engagements; plural build modules engaged with the conveyor system, wherein the build modules receive and temporarily retain powder from a powder layering system, and wherein a build module comprises: 1) one or more sidewalls defining a cavity; and 2) an incrementally height adjustable platform (punch) disposed within the cavity; at least one build station comprising: 1) at least one powder layering system that forms incremental powder layers within the cavity and comprises at least one powder fill head, at least one powder spreader and at least one powder reservoir; and 2) at least one printing system that applies a liquid according to at least one predetermined pattern to the incremental powder layers and comprises at least one liquid feed system and at least one print head that deposits liquid according to the at least one predetermined pattern; at least one punch system comprising at least one upper punch; wherein the conveyor system repeatedly transports the plural build modules from the at least one powder layering system to the at least one printing system, whereby the three-dimensional printing build system: 1) forms at least one incremental printed layer per build lap in a build module; 2) forms a single 3DP article per build cycle in a build module; 3) forms plural 3DP articles per build cycle in a build module; or 4) forms a 3DP bed comprising one or more three-dimensionally printed articles and, optionally, loose (unbound or only partially bound) powder that has not been printed upon per build cycle in a build module; b) optionally, at least one harvesting system that separates loose powder from: 1) one or more incremental printed layers; 2) one or more 3DP articles; or 3) one or more 3DP beds; and c) optionally, at least one liquid removal system that removes liquid from: 1) one or more incremental printed layers of an in-process incompletely formed 3DP article; 2) one or more 3DP articles after printing thereof; or 3) one or more 3DP beds.", "Some embodiments of the invention include those wherein: 1) at least one liquid removal system is present; 2) the equipment assembly further comprises at least one packaging system that packages one or more three-dimensionally printed articles; 3) the conveyor system repeatedly transports plural build modules from the at least one powder layering system to the at least one printing system in a linear manner thereby facilitating Cartesian coordinate printing or in a radial manner thereby facilitating polar coordinate printing; 4) the equipment assembly further comprises a powder recovery system for recovering, and optionally recycling, unprinted powder; 5) the equipment assembly further comprises a liquid detector; 6) a liquid detector detects the presence of liquid in one or more printed incremental layers and/or in one or more printed articles; 7) the equipment assembly further comprises an inspection system; 8) an inspection system is a printed powder inspection system that determines the integrity of printing in one or more incremental printed layers and/or one or more printed articles and/or determines whether or not powder was properly applied in one or more incremental layers; 9) determining the integrity of printing comprises at least one of determining whether or not liquid has been correctly applied to one or more incremental layers according to one or more predetermined patterns and/or determining whether or not liquid has been correctly applied to one or more incremental layers according to a predetermined amount; 10) the inspection system is a printed article inspection system that determines whether or not one or more printed articles have the correct size, shape, weight, appearance, density, content and/or color; 11) the inspection system is a liquid application inspection system that monitors droplets of liquid applied by the print head to powder; 12) the inspection system comprises one or more cameras; 13) a camera is independently selected at each occurrence from the group consisting of a visible wavelength camera, an UV wavelength camera, a near infrared wavelength camera, an x-ray camera and an infrared wavelength camera; and/or 14) the equipment assembly excludes a powder recovery system for recovering and recycling unprinted powder.", "The invention includes all combinations of the embodiments, subembodiments and aspects disclosed herein.", "Accordingly, the invention includes the embodiments and aspects specifically disclosed, broadly disclosed, or narrowly disclosed herein, as well as combinations thereof and subcombinations of the individual elements of said embodiments and aspects.", "The invention can be a combination of two or more elements described herein or specified in the claims.", "The invention is substantially as described herein.", "In some embodiments, the invention is substantially as described in one or more drawings.", "Other features, advantages and embodiments of the invention will become apparent to those skilled in the art by the following description, accompanying examples.", "BRIEF DESCRIPTION OF THE FIGURES The following figures form part of the present description and describe exemplary embodiments of the claimed invention.", "These drawings are not necessarily drawn to scale, and are instead intended to illustrate the general principles of the invention as further described herein.", "Although specific embodiments are described below with specific reference to the drawings provided, other embodiments are possible without deviating from the spirit and scope of the present invention.", "The skilled artisan will, in light of these figures and the description herein, be able to practice the invention without undue experimentation.", "FIGS.", "1A-1D depict top plan views of prior art open-bed build modules of a three-dimensional printing equipment assembly of U.S. Pat.", "No.", "8,888,480, wherein plural articles are printed in a single bed of loose powder.", "FIGS.", "2A-2G depict top plan views of build modules of the invention.", "FIGS.", "3 and 4 depict top plan views of exemplary three-dimensional printing equipment assemblies (or apparatuses) of the invention.", "FIGS.", "5A-5J depict top plan views of the exemplary three-dimensional printing equipment assembly (or apparatus) of FIG.", "3 during in-process use for the preparation of single 3DP articles in cavities.", "FIG.", "6 depicts a perspective view of another exemplary three-dimensional printing equipment assembly (or apparatus) of the invention.", "FIG.", "7 depicts a top plan view of another exemplary three-dimensional printing equipment assembly (or apparatus) of the invention.", "FIG.", "8 depicts a perspective view of another exemplary three-dimensional printing equipment assembly (or apparatus) of the invention.", "FIGS.", "9A-9I depict partial sectional side elevation views of an exemplary punch system, exemplary powder layering system and exemplary liquid deposition (printing) system during in-process use for the preparation of an uncompressed 3DP article in a cavity.", "FIGS.", "10A-10C depict partial sectional side elevation views of an exemplary punch system during in-process use for the preparation of a compressed 3DP article in a cavity.", "FIGS.", "11A-11E depict partial sectional side elevation views of four different exemplary punch systems during in-process use for the preparation of compressed 3DP articles in respective cavities.", "FIGS.", "12A and 12B depict partial sectional side elevation views of an exemplary punch system during in-process use for discharging a 3DP article from a cavity.", "FIG.", "13 depicts a perspective view of a prior art uniaxially compressed 3DP dosage form according to U.S. Pat.", "No.", "7,931,914 and U.S. Pat.", "No.", "8,758,658.FIGS.", "14A and 14B depict perspective views of exemplary 3DP articles of the invention comprising regions or incremental layers differing in porosity (density).", "FIGS.", "15A-15B depict cross-sectional side elevation views of exemplary 3DP articles of the invention.", "FIG.", "15C depicts a top plan view of an exemplary 3DP article of the invention.", "FIG.", "15D depicts a perspective view of an exemplary 3DP article of the invention.", "FIG.", "15E depicts a cross-sectional side view of an exemplary 3DP article of the invention.", "FIG.", "16 depicts a partial sectional side elevation view of an exemplary liquid removal system, lower punch and build module of the invention.", "FIG.", "17 depicts a partial sectional side elevation view of an exemplary liquid removal system, lower punch and build module of the invention.", "FIG.", "18 depicts a perspective view of another exemplary three-dimensional printing equipment assembly (or apparatus) of the invention.", "FIG.", "19 depicts a partial sectional side elevation view of an exemplary build module, height adjustable platform and lower punch of the invention.", "FIG.", "20 depicts a partial sectional side elevation view of an exemplary powder layering system and build module of the invention.", "FIG.", "21 depicts a top plan view of an exemplary powder layering system and exemplary turret with plural receptacles.", "FIG.", "22 depicts a partial sectional perspective view of a 3DP apparatus of the invention.", "FIGS.", "23-25 depict perspective views of three different exemplary 3DP equipment assemblies (or apparatuses) of the invention.", "FIG.", "26 depicts a partial sectional side elevation view of an exemplary punch system and exemplary build module of the invention.", "FIG.", "27 depicts a top plan view of an exemplary 3DP equipment assembly (or apparatus) of the invention.", "FIG.", "28 depicts a top plan view of an exemplary continuous 3DP equipment assembly having a racetrack conveyor, plural build stations and an article transfer system.", "FIG.", "29 depicts a top plan view of another exemplary continuous 3DP equipment assembly having a linear conveyor and plural build stations.", "FIG.", "30 depicts a top plan view of another exemplary continuous 3DP equipment assembly having a linear conveyor, plural build stations and an article transfer system.", "FIG.", "31 depicts a top plan view of a portion of another exemplary continuous 3DP equipment assembly having a conveyor, build station and article transfer system.", "FIG.", "32 depicts a top plan view of an exemplary continuous 3DP equipment assembly having a segmented conveyor with horizontal displacement, plural build stations and an article transfer system.", "FIG.", "33 depicts a side elevation view of an exemplary continuous 3DP equipment assembly having a modular conveyor with vertical displacement and a build station.", "FIG.", "34 depicts a top plan view of an exemplary continuous 3DP equipment assembly having a conveyor, plural powder layering systems, plural printing systems, plural punch systems, plural drying systems, computer controller, an article transfer system and optionally one or more inspection systems.", "FIG.", "35 depicts an overall process flow diagram indicating movement of 3DP articles through various parts of the equipment assembly.", "FIG.", "36 depicts a top plan view of an exemplary layout of an exemplary multi-cavity three-dimensional printing equipment assembly.", "FIG.", "37 depicts a perspective view of an exemplary multi-cavity build module.", "FIG.", "38 depicts a side elevation view of an exemplary printing system.", "FIG.", "39 depicts a bottom perspective view of an exemplary layout of print modules in the print head of a printing system.", "FIG.", "40 depicts bottom plan views of alternate exemplary layouts for the print modules in different print heads.", "FIG.", "41 depicts a side elevation view of an exemplary powder layering system.", "FIG.", "42 depicts a perspective view of a powder layering system and multi-cavity build module during in-process use.", "FIG.", "43 depicts a partial top plan view of an exemplary multi-cavity build module and a build station comprising a powder layering system and a printing system.", "FIGS.", "44A-44D depict top plan views of various different embodiments of a print head and arrangements thereof.", "FIG.", "45 depicts a sectional side elevation view of an exemplary article drying system.", "FIG.", "46 depicts a side elevation view of an exemplary article packaging system.", "FIGS.", "47-49 together depict an exemplary logic flow for operation of the equipment assembly of the invention.", "FIG.", "47 continues to FIG.", "48, which continues to FIG.", "49, which refers back to FIG.", "47.FIG.", "50 depicts an exemplary logic flow for operation of the powder layering system.", "FIG.", "51 depicts an exemplary logic flow for operation of the printing system.", "FIG.", "52 depicts an exemplary logic flow for design of a dosage form.", "FIG.", "53 depicts an exemplary logic flow for general operation of a 3DP system with an in-process layer punch system and in-process layer drying system.", "FIG.", "54 depicts an exemplary logic flow for operation of the punch system depending upon which operation the punch system is to conduct.", "FIG.", "55 depicts an exemplary logic flow for conducting a translation operation with a punch system.", "FIG.", "56 depicts an exemplary logic flow for conducting a compression operation with a punch system.", "FIG.", "57 depicts an exemplary logic flow for conducting a marking or shaping operation with a punch system.", "FIG.", "58 depicts a perspective view of a turret disc assembly.", "FIG.", "59 depicts a cross-sectional side elevation view of the turret disc assembly of FIG.", "58.FIG.", "60 depicts a perspective view of a 3DP equipment assembly employing a removable turret disc.", "DETAILED DESCRIPTION OF THE INVENTION The invention provides an equipment assembly and system useful for the manufacture of articles via a three-dimensional printing process.", "The assembly and system are suitable for small scale/volume, medium scale/volume and large scale/volume preparation of articles.", "The three-dimensional printing (3DP) process comprises forming an incremental layer of powder on a surface and subsequently printing/applying a liquid onto the layer, then repeating the steps of forming and printing a sufficient number of times to form a 3DP article on the surface or form a a printed powder bed comprising one or more 3DP articles and loose powder.", "Any excess/undesired liquid remaining in the article(s) is removed and the loose powder, if any, is separated from the article(s), which is(are) then collected.", "As used herein, 3DP means three-dimensional printing, three-dimensionally printed or other such conjugation thereof.", "As used herein, “cavity three-dimensional printing” or “cavity 3DP” or “c3DP”, means three-dimensional printing in which the layer-by-layer (incremental layer-by-incremental layer) assembly steps are carried out in one or more cavities that are sized to fit individual articles, with little or no unprinted powder surrounding each article (or incremental layer) within each cavity, or otherwise with a minimum of loose powder surrounding each article in each cavity.", "In other words, the cavity, which has a top-plan view defined by an interior periphery (edge), is charged with a layer of powder, and binding fluid is applied at least to the outer periphery of the layer of powder adjacent the inner periphery of the cavity to form an article such that only a minimal amount, if any, of unprinted powder remains between the cavity surface and the printed powder.", "As used herein with regard to the invention, the term “tamping” is used interchangeably with the term “compressing”, unless otherwise specified.", "Tamping is effected with the punch system, whereby one or more incremental layers or powders layers of an in-process 3DP article within a cavity is/are compressed.", "The punch system comprises an upper punch superposing a cavity and a lower punch or lower height adjustable platform disposed within a cavity.", "In some embodiments, the tamping is affected by: a) lowering the upper punch into the cavity before lowering the lower punch or platform in the cavity; b) lowering the upper punch into the cavity a greater distance than the lower punch or platform in the cavity is lowered; c) raising the lower punch or platform in a cavity before raising the upper punch in the cavity; or d) raising the lower punch or platform in a cavity a greater distance than the upper punch in the cavity is raised.", "A process of the invention can comprise one or more tamping steps.", "As used herein, “translating” or “translation” (or other conjugation thereof) refers to the act or result of vertically (and linearly) displacing or moving one or more incremental layers within a cavity by use of the punch system.", "Translating and translation are considered non-compressive or essentially non-compressive actions, whereby a 3DP article or one or more layers in a cavity are pushed downward or upward by use of the punch system with essentially no change in the volume of the 3DP article.", "In some embodiments, the translation is affected by: a) lowering the upper punch and the lower punch or platform in a cavity the same or about the same distance; or b) raising the upper punch and the lower punch or platform in a cavity the same or about the same distance.", "In some embodiments the timing of the translation is effectuated by: a) lower and upper punch moving at approximately the same time; b) the lower punch moving before the upper punch, for a downward movement; c) the upper lunch moving before the lower punch, for an upward movement.", "As used herein, “marking” refers to the act of forming at least one raised or lowered feature on the surface of an incremental layer (be it an incremental powder layer or incremental printed layer) such that the surface is no longer a strictly flat surface, meaning it is a non-flat surface.", "Marking is achieved by contacting the surface of the layer with a punch (or platform) such that an impression is made upon the surface.", "This meaning of marking is distinct from prior noncontact marking effectuated by 3DP (“noncontact 3DP marking”), such as the creation of recessed features via the exclusion of droplets in select exterior regions of an article, allowing the unbound powder to empty out.", "Such noncontact 3DP marking is discussed in U.S. Pat.", "No.", "8,828,411.Such noncontact techniques for marking during 3DP may be considered option, either alone or in combination with the marking described herein.", "As use herein in reference to an incremental layer, “shaping” refers to the act of altering the shape of one or more surfaces of an incremental layer or the shape of an entire layer such that the upper and lower surfaces of an incremental layer are not both flat parallel planes.", "Opposing surfaces of an incremental layer may or may not be flat, but they are not simultaneously flat and parallel planes.", "Both surfaces may be simultaneously flat, but they would also be non-parallel.", "A contoured, embossed or debossed surface is considered a non-flat surface.", "Shaping is achieved by contacting one or more surfaces of an incremental layer with a punch (or platform) such that the upper and lower surfaces of an incremental layer are not both flat parallel planes, and may include one or more of a contoured, an embossed, or a debossed surface.", "A process of the invention can comprise one or more translating steps, one or more tamping (compressing) steps, one or more marking steps and/or one or more shaping steps.", "Generally, a 3DP equipment assembly, apparatus or system comprises various subsystems including one or more three-dimensional printing build systems, one or more harvesting systems, and optionally one or more liquid removal systems.", "The equipment assembly can comprise one or more three-dimensional printing build systems, one or more harvesting systems, one or more liquid removal (drying) systems and optionally one or more other systems.", "In some embodiments, the equipment assembly further comprises one or more (sub)systems selected from the group consisting of one or more punch systems, one or more discharge systems, one or more powder recovery systems, one or more control systems, one or more build module or conveyor positioning systems, one or more conveyor drive motors, one or more article transfer systems, one or more inspection systems and one or more bed transfer systems.", "The 3DP equipment assembly, apparatus or system can comprise some or all of the above systems.", "For example, in certain embodiments of a cavity 3DP equipment assembly, apparatus, or system, it is not necessary to have a harvesting system since substantially all of the powder material entering a cavity is incorporated into a respective article formed within the cavity, with little or no excess powder for separation.", "As used herein, a “three-dimensional printing build system” generally comprises a conveyor system, at least one build module, at least one build station, and optionally one or more other components.", "The function of the three-dimensional printing build system is to form one or more three-dimensionally printed articles from a multilayered bed of powder in a build module.", "In some embodiments, the 3DP build system forms a single 3DP article per build cycle in a cavity (receptacle).", "One or more, or plural, build modules are engaged with a conveyor system that is adapted to conduct the build module(s) along a predetermined path which passes through one or more build stations.", "A build module is conducted to a powder layering system (region), and an incremental powder layer is formed in the cavity.", "The build module is then conducted to a printing system (region), and a binding fluid is applied to the incremental powder layer according to a predetermined pattern thereby forming a partially or fully bound powder layer (an incremental printed layer).", "The steps of conducting the build module, forming an incremental powder layer and applying a liquid to the layer to form an incremental printed layer are considered to be a single build lap of the process.", "Build laps are repeated such that an incremental printed layer from one lap adheres to a printed incremental layer from a prior or subsequent lap.", "Build laps are repeated in build modules a sufficient number of times to form single 3DP articles per cycle in build modules or to form a three-dimensionally printed bed comprising one or more three-dimensionally printed articles and loose powder, wherein the three-dimensionally printed article(s) comprise(s) at least two printed incremental layers.", "The liquid applied to the powder may or may not dry sufficiently under ambient conditions between build laps; therefore, a liquid removal step can be included between build laps.", "In some embodiments, a dryer is present in the build station in order to dry in-process incremental layers after deposition of binding fluid.", "In such embodiments, a build lap would comprise the steps of conducting the build module, forming an incremental powder layer in the build module, applying a liquid to the powder layer to form an incremental printed layer, and exposing the printed layer to a dryer.", "If, however, the incremental layer does not dry sufficiently during build laps, then an optional liquid removal step can be conducted following completion of all the build laps, i.e.", "following completion of a build cycle, for a three-dimensionally printed article.", "In other words, a 3DP article that has completed a build cycle can be dried in an article dryer if needed.", "The conveyor system is adapted to conduct one or more build modules through a predetermined course/path during and between build laps.", "Substantially any system useful for conveying solid materials from a first location to a second location and back to the first location can be used.", "In some embodiments, the conveyor system is a cyclic, linear, reciprocating or oscillating conveyor system.", "In some embodiments, the cyclic conveyor system conducts build modules from the first location to a second location and then back to the first location.", "In some embodiments, the conveyor system is a cyclic or iterative conveyor system that repeatedly conducts build modules through one or more build station(s).", "In some embodiments, the linear conveyor system conducts build modules from a first build station to a second build station and optionally one or more other build stations.", "In some embodiments, the oscillating system conducts one or more build modules through at least one build station in a first direction and then conducts the one or more build modules through the at least one build station in an opposite direction.", "FIGS.", "1A-1D depict top plan views of prior art open-bed build modules of a 3DP equipment assembly of U.S. Pat.", "No.", "8,888,480, wherein plural articles are printed in a single bed of loose powder.", "The open bed system of FIG.", "1A comprises a build module (1) having a single cavity (2) within which plural 3DP articles (3) are printed leaving behind a substantial amount of unprinted powder (4).", "The inner periphery (edge) defining the top plan view of the cavity is not shaped like the outer periphery of the 3DP articles in the printed powder bed.", "The open bed system of FIG.", "1B is very similar to that of FIG.", "1A.", "It comprises a build module (5) and a cavity (6) within which plural 3DP articles (7) are printed leaving behind a substantial amount of unprinted powder (8).", "The open bed build module (10) of FIG.", "1C can be used to prepare multiple triangular 3DP articles; however, there is still a substantial amount of unprinted powder (11) that must be disposed of or recycled.", "The same is true of the build module (12) and unprinted powder (13) of FIG.", "1D.", "Although FIG.", "1C and FIG.", "1D show much closer article-to-article spacing due to advantages in shape and packing, some unprinted powder is still required between articles to keep them from binding to one another.", "The print patterns for FIGS.", "1A-1D differ but both leave behind a substantial amount of unprinted powder that must be separated from the articles and then recycled or disposed of This is because the inner periphery of the top plan view of their respective cavities is not adjacent the outer periphery of the plan view of their respective 3DP articles.", "Thus prior art open bed systems have the key disadvantage of substantial waste of bulk powder or the requirement for disposal or recycle of substantial amounts of bulk powder.", "Another key disadvantage of open bed systems is that they do not permit recycling of and require disposal of the unprinted powder whenever two different bulk powders are used to form the layers, because the two different bulk powders become mixed during the harvesting step of the process.", "The key disadvantage is overcome with the cavity 3DP system of the invention, which is capable of printing 3DP articles comprising incremental layers made of different bulk powders while minimizing or eliminating the disposal of bulk powder.", "The cavity 3DP system of the invention, however, is able to minimize and even eliminate the need to dispose of or recycle bulk powder.", "FIGS.", "2A-2G depict top plan views of build modules and their respective cavities (receptacles) of the invention.", "The build module (15) of FIG.", "2A comprises a cavity, the top plan view of which is defined by an inner periphery (edge, 17).", "A 3DP article (18) is printed within the cavity.", "The outer periphery of the plan view of the 3DP article (18) approximates the inner periphery of the top plan view of the cavity.", "During the build cycle, binding fluid is applied to outer periphery of respective powder layers such that the binding fluid is adjacent (or minimally spaced away from) the inner periphery of the cavity.", "As a result, little to no bulk powder needs be disposed of or recycled.", "The build module (20) of FIG.", "2B operates in the same manner as that of FIG.", "2A except that the cavity and print patter are hexagonally rather than circularly shaped.", "The build module (21) of FIG.", "2C operates in the same manner as that of FIG.", "2A except that the cavity and print patterns are heart-shaped rather than circularly shaped.", "The build module (22) of FIG.", "2D comprises a body (23) having an edge (23A) defining an outer periphery of the cavity.", "A height adjustable platform is disposed within the cavity and it has a top plan view that is shaped similar to the top plan view of the cavity.", "The build module also comprises stands (24, 25), which are not height adjustable and which are defined by respective edges (peripheries, 24A, 25A).", "As a result of this configuration, the 3DP article (26) comprises an annular portion (26B) and a connecting portion (26A).", "Accordingly, the cavity 3DP system of the invention can be used to prepare 3DP articles with sharper surface features than those of prior art 3DP systems (such as open bed 3DP systems) and can do so with a much higher incorporate rate of cavity powder into final article.", "As an improved alternative to open bed systems, the build module (30) of FIG.", "2E comprises plural cavities (receptacles, 31-34) within which respective single 3DP articles (35) are formed.", "A build module of the invention can comprise a body and plural cavities, the top plan view of each cavity being defined by an edge approximating the plan view of a 3DP article to be printed in the cavity, wherein the build module further comprises a height adjustable platform (or punch) in each build cavity, and the top plan view of the platform (or punch) approximates the top plan view of its respective cavity.", "The build module (36) of FIG.", "2F is for an improved open bed system.", "The build module comprises a cavity the top plan view of which is defined by the edge (38), such that the edge (38) approximates the outer periphery of the plan view of articles (37) printed within the cavity.", "In the narrow example of FIG.", "2F, opposing portions (39) of the edge (38) are very closely spaced or in contact with one another.", "The build module (40) of FIG.", "2G comprises a cavity having a top plan view defined by an edge (41) in the body of the build module.", "The shape of the outer periphery of the plan view of the article (42) approximates the shape of the edge (41).", "The improved systems of FIGS.", "2A-2G do not require disposal or recycle of large amounts of unprinted powder.", "The 3DP equipment assembly (or apparatus) (45) of FIG.", "3 comprises a powder layering region (Z-1), a printing region (Z-2), a liquid removal region (Z-3) and a punch region (Z-4).", "The assembly comprises a stationary body and a conveyor (47) which comprises plural build modules (48) with respective cavities.", "The conveyor conducts the build modules in a circuitous path in the direction of Arrow (A) from region (Z-1) to region (Z-2) to region (Z-3) to region (Z-4) per build lap.", "The assembly also comprises a discharge region, substantially integral with the punch region, wherein the 3DP articles are discharged from their respective cavities.", "The 3DP equipment assembly (or apparatus) (50) of FIG.", "4 is similar to that of FIG.", "3, except that the discharge region (Z-5) is now separate from the punch region (Z-4).", "In this case, the assembly may comprise two (full or partial) punch systems.", "A full punch system comprises: a) an upper punch and a lower punch, optionally in a cavity; or b) an upper punch and a lower height adjustable platform in a cavity.", "A partial punch system comprises: a) an upper punch; b) a lower punch in a cavity; or c) a lower height adjustable platform in a cavity.", "FIGS.", "5A-5I depict top plan views of the exemplary three-dimensional printing equipment assembly (or apparatus) of FIG.", "3 during in-process use for the preparation of single 3DP articles in respective cavities (C-1 through C-8).", "In FIG.", "5A (phase I), a layer of powder is added to cavity (C-1) in the powder layering region (Z-1).", "The conveyor is advanced clockwise to place cavity (C-2) in the region (Z-1), whereby the cavity (C-2) receives its layer of powder and cavity (C-1) approaches the printing region (Z-2) (FIG.", "5B, phase II).", "The conveyor is again advanced clockwise (FIG.", "5C, phase III), whereby the cavity (C-3) receives its layer of powder, cavity (C-2) approaches the printing region (Z-2), and the layer in cavity (C-1) is printed upon.", "The conveyor is again advanced clockwise (FIG.", "5D, phase IV), whereby the cavity (C-4) receives its layer of powder, cavity (C-3) approaches the printing region (Z-2), the layer in cavity (C-2) is printed upon and cavity (C-1) approaches the drying region (Z-3).", "The conveyor is again advanced clockwise (FIG.", "5E, phase V), whereby the cavity (C-5) receives its layer of powder, cavity (C-4) approaches the printing region (Z-2), the layer in cavity (C-3) is printed upon, cavity (C-2) approaches the drying region (Z-3), and the printed layer in cavity (C-1) is dried.", "The conveyor is again advanced clockwise (FIG.", "5F, phase VI), whereby the cavity (C-6) receives its layer of powder, cavity (C-5) approaches the printing region (Z-2), the layer in cavity (C-4) is printed upon, cavity (C-3) approaches the drying region (Z-3), the printed layer in cavity (C-2) is dried, and cavity (C-1) approaches the punch region (Z-4).", "The conveyor is again advanced clockwise (FIG.", "5G, phase VII), whereby the cavity (C-7) receives its layer of powder, cavity (C-6) approaches the printing region (Z-2), the layer in cavity (C-5) is printed upon, cavity (C-4) approaches the drying region (Z-3), the printed layer in cavity (C-3) is dried, cavity (C-2) approaches the punch region (Z-4), and the incremental layer in cavity (C-1) is translated downward to create a space above it for receiving additional powder when in the powder layering region (Z-1).", "The conveyor is again advanced clockwise (FIG.", "5H, phase VIII), whereby the cavity (C-8) receives its layer of powder, cavity (C-7) approaches the printing region (Z-2), the layer in cavity (C-6) is printed upon, cavity (C-5) approaches the drying region (Z-3), the printed layer in cavity (C-4) is dried, cavity (C-3) approaches the punch region (Z-4), the incremental layer in cavity (C-2) is translated downward, and cavity (C-1) approaches the powder layering region (Z-1).", "The above steps define a single build lap for this specific embodiment.", "The build lap is repeated as many times as required to form a 3DP article comprising plural printed incremental layers.", "After completion of a build cycle, each article is discharged from its respective cavity.", "For example, FIG.", "5I depicts initiation of the discharge phase.", "Notice that in-process (incomplete) article of cavity (C-8) is approaching the powder layering region (Z-1) but the completed article in cavity (C-1) has been discharged.", "The conveyor is again advanced clockwise (FIG.", "5J), whereby the empty cavity (C-1) approaches the powder layering region (Z-1) in preparation of receiving another layer of powder to initiate formation of another 3DP article.", "FIG.", "6 depicts a perspective view of another exemplary three-dimensional printing equipment assembly (or apparatus) (55), which comprises a powder layering system (56) in the respective region (Z-1), a printing system (60) in the respective region (Z-2), a drying system (61) in the respective region (Z-3), and punch system (63) in the respective region (Z-4).", "The powdering layering system, which comprises a powder feed system or reservoir (57) is held in place by at least one support (58).", "The drying system is held in place by at least one support (62).", "The printing system and punch system are also held in place by supports (not shown).", "The assembly comprises a stationary body (67), within which a conveyor (69, in this case a turret) comprising a motor drive (66) and plural build modules with respective cavities (68) rotates (spins) to conduct the cavities sequentially through each of the process regions.", "The punch system (63) comprises a punch (64) with a tip having a periphery that approximates the periphery of the cavities such that the punch can slide in and out of the cavities.", "Completed articles are discharged through the discharge port (65) or chute.", "FIG.", "7 depicts a top plan view of another exemplary three-dimensional printing equipment assembly (or apparatus) (70) of the invention.", "It comprises a powder layering region/system (Z-1), a first punch region/system (Z-6), a printing region/system (Z-2), a drying region/system (Z-3), and a second punch region/system (Z-4).", "Even though the sequential order of the systems of assembly (70) is depicted as (Z-1) to (Z-6) to (Z-2) to (Z-3) to (Z-4), the order can be (Z-1) to (Z-2) to (Z-6) to (Z-3) to (Z-4), or (Z-1) to (Z-2) to (Z-3) to (Z-6) to (Z-4), or (Z-1) to (Z-2) to (Z-3) to (Z-6), or (Z-1) to (Z-2) to (Z-3) to (Z-4).", "The first punch system can be used to translate or compress material in a cavity within the corresponding region.", "It may also be used to smooth the surface of the material.", "It may also be used to form or shape the surface, i.e.", "to contour, emboss, deboss or otherwise mark the surface, of the material before printing.", "The second punch system can be used to translate or compress material in a cavity within the corresponding region.", "It may also be used to form or shape the surface, i.e.", "to contour, emboss, deboss or otherwise mark the surface, of the material before discharging or additional printing.", "It may also be used to discharge a 3DP article from the cavity.", "FIG.", "8 depicts a perspective view of an exemplary 3DP equipment assembly (or apparatus) (71) of the invention.", "It is similar to the assembly/apparatus of FIG.", "7 in terms of the arrangement or sequence of the respective regions/systems; however, the assembly of FIG.", "8 depicts alternative embodiments of the first (Z-6) and second (Z-4) punch systems.", "The first punch system comprises an upper punch (72) and a lower punch (73).", "They are depicted in dashed lines because either one of the two may be absent or both may be present, meaning that the first punch system can comprise the upper punch and/or the lower punch.", "The second punch system comprises an upper punch (63) and a lower punch (74).", "They are depicted in dashed lines because either one of the two may be absent or both may be present, meaning that the second punch system can comprise the upper punch and/or the lower punch.", "The second punch system can be used to discharge a 3DP article by pushing it upwards or downwards out of its respective cavity.", "FIGS.", "9A-9I depict partial sectional side elevation views of an exemplary punch system, exemplary powder layering system (81), exemplary build module (83) (with cavity) and exemplary liquid deposition (printing) system (90) during in-process use for the preparation of incremental layers of an uncompressed 3DP article in a cavity.", "In FIG.", "9A, a first incremental printed layer (85) has already been formed in the cavity of the build module (83).", "The powder layering system (81) is depicted as having charged loose powder (86) on top of the printed layer.", "The lower punch (84) is disposed in the cavity and helps maintain the in-process materials in place.", "The cavity is then conducted to an optional first punch system comprising the upper punch (86, FIG.", "9B), which can be lowered (Arrow J, FIG.", "9C) onto the loose powder to smooth, contour, modify or mark its surface.", "The upper punch is then raised (Arrow K, FIG.", "9D) and the cavity is conducted to the printing system (90, FIG.", "9E), which deposits droplets of binding fluid (91) onto the powder layer such that the in-process (incomplete) 3DP article (92) now comprises two incremental printed layers.", "After an optional drying step (not depicted), the cavity is then conducted to a second punch system (FIG.", "9F), which translates the in-process article (92) downwardly (Arrow J) in the cavity by a vertical distance corresponding to the vertical height (thickness) of the next incremental powder layer to be added to the cavity.", "After raising the upper punch (Arrow K, FIG.", "9G), the cavity is conducted to a powder layering system and charged with another incremental powder layer (93, FIG.", "9H), thereby leaving behind the in-process article (94, FIG.", "9I) in the cavity.", "FIGS.", "10A-10C depict an alternate embodiment of the steps depicted in FIGS.", "9F-9G.", "Here, the in-process article (92, FIG.", "10A) is compressed by lowering the upper punch (Arrow J, FIG.", "10B) into the cavity without lowering or prior to lowering the lower punch, thereby forming the compressed in-process article (5).", "A space for receiving the next layer is thus created in the cavity (FIG.", "10C).", "The use of punches during the formation steps of a 3DP article for the first time in powder-layering based 3DP technology allows for the formation of 3DP articles comprising compressed and non-compressed incremental printed layers.", "Accordingly, the invention also provides a 3DP article comprising one or more compressed incremental printed layers and one or more non-compressed incremental printed layers.", "Even though the surfaces of the upper and lower punches that contact the in-process 3DP article are depicted as being flat in the embodiments thus far, the surfaces of the punches can be non-flat, meaning shaped (or contoured) as desired.", "The upper punch (96, FIG.", "11A) comprises a convex lower face (97, surface) that forms a corresponding concave face (98) on an incremental layer.", "Both the upper (96) and lower (99) punches of FIG.", "11B comprise convex faces that form corresponding concave faces on an in-process article.", "The upper punch (100, FIG.", "11C) comprises a concave lower face (101, surface) that forms a corresponding complementary convex face (102) on an incremental layer.", "Both the upper (100) and lower (104) punches of FIG.", "11D comprise concave faces that form corresponding complementary convex faces (103) on an incremental layer.", "Both the upper (118) and lower (119) punches of FIG.", "11E have complex contoured faces that form complementary complex contoured faces (114) on an incremental layer.", "The use of punches with contoured (non-flat) faces for the first time in powder-layering based 3DP technology allows for the formation of 3DP articles comprising partially or non-uniformly compressed incremental printed layers.", "Accordingly, the invention also provides a 3DP article comprising one or more partially or non-uniformly compressed incremental printed layers, or comprising one or more partially or non-uniformly compressed incremental printed layers and one or more non-compressed incremental printed layers.", "The invention also provides a 3DP article comprising one or more contoured (non-flat) incremental printed layers, or comprising one or more contoured incremental printed layers and one or more non-contoured (flat) incremental printed layers.", "Other punch faces are contemplated.", "A punch face may comprise raised (or potentially recessed) lettering, numbering, or other symbols in order to provide an imprint into an exterior or interior incremental layer of a 3DP article that reflects the contour of the punch face in reverse (i.e., a raised feature on the punch face creating a lowered feature on the incremental layer, and vice versa).", "The punch face may include specific patterns or textures with a similar goal of creating and imprint into an interior or exterior incremental layer of a 3DP article.", "In certain embodiments, the pattern or texture of features on the punch face allows the powder from more than one incremental layer to mingle within the same horizontal slice of a 3DP article.", "For example, in a case for which there are two sequential incremental layers with different respective powders, instead of each powder substantially remaining within its own respective layer, one or both powders may shift upward or downward into a neighboring incremental layer when displaced by the action of a non-smooth punch face having raised or recessed features.", "In certain embodiments, this may include depressions that are created in an instant incremental layer comprised of a first powder that are subsequently filled with a second powder on the next powder spreading step, or this may include raised areas in an instant incremental layer comprised of a first powder and extending into the space allocated for the next incremental layer having a second respective powder, or combinations of both.", "The punch system can be used to discharge a 3DP article from a cavity.", "FIGS.", "12A-12B depict the use a lower punch to discharge the 3DP article (105) from a cavity in the build module (123) by pushing the article upwardly (Arrow K) and out of the cavity.", "The discharged article can then be conducted away from the build module by an article transfer system.", "FIG.", "13 depicts a perspective view of a prior art uniaxially compressed 3DP dosage form (106B) according to U.S. Pat.", "No.", "7,931,914 and U.S. Pat.", "No.", "8,758,658, wherein the non-compressed 3DP dosage form (106A) is uniaxially compressed after completion of the build cycle and completion of the drying cycle.", "The entire uniaxially compressed dosage form (106B) comprises only uniformly compressed printed incremental layers, because the entire dosage form was uniformly uniaxially compressed after formation of all the incremental layers.", "It does not comprise a combination of compressed and non-compressed incremental printed layers.", "It does not comprise a non-uniformly compressed incremental printed layer or a combination of a non-uniformly compressed incremental printed layer and a non-compressed incremental printed layer.", "The assembly (apparatus) and method of the invention, however, now permit the formation of powder layering-based 3DP articles having complex internal and external geometries.", "The 3DP article (107) of FIG.", "14A comprises a non-compressed incremental printed layer (108) and a compressed incremental printed layer (109).", "The 3DP article (110) of FIG.", "14B comprises a first section (111) of non-compressed incremental printed layers (first lowest density section), a second section (112) of lightly compressed incremental printed layers (second intermediate density section), and a third section (113) of more heavily compressed incremental printed layers (third highest density section).", "Other 3DP articles comprising compressed and non-compressed incremental printed layers of varying geometries can also be prepared.", "The 3DP article (115) of FIG.", "15A comprises upper and lower higher density sections (117) and an intermediate lower density section (116).", "The 3DP article (120) of FIG.", "15B comprises a first section (121) comprising a first bulk powder and a second section (122) comprising a second bulk powder, wherein the powders differ in composition.", "The use of non-flat punches faces now permits preparation of powder-layering based 3DP articles having embossed or debossed surface features.", "The 3DP article (124) of FIG.", "15C comprises a face with a debossed (lowered) feature (125).", "The 3DP article (126) of FIG.", "15D comprises opposing faces with corresponding embossed (raised) features (128).", "The 3DP article (124) of FIG.", "15C can be modified to include more than one bulk powder composition in an incremental printed layer.", "FIG.", "15 depicts a sectional side elevation view of the 3DP article (124) comprising lower (124b) and upper (124a) printed layers, each made from a first bulk powder onto which a first binding fluid has been deposited.", "The upper layer includes the space (125) created by using a punch with a non-flat surface (an embossed face).", "The space has been filled in with a second bulk powder that is different in composition than the first bulk powder of the layers (124a, 124b).", "As a result, the incremental printed layer (124a) comprises at least one first portion (region), made from a first bulk powder and a first binding fluid, and at least one second portion (region), made from a second bulk powder and second binding fluid.", "The first and second portions are horizontally adjacent (immediately adjacent).", "The first bulk powder is different from the second bulk powder.", "The first and second binding fluids can be the same or different.", "The difference(s) can be difference(s) in composition and/or physical properties.", "FIG.", "16 depicts a partial sectional side elevation view of an exemplary liquid removal system (130), lower punch (138) and build module of the invention.", "This liquid removal system (dryer) is particularly suitable for removing liquid from incremental printed layers during preparation of an in-process 3DP article.", "It comprises a body (131) having a duct (133) for conducting air from a source (132) through to the surface of the target incremental layer (137).", "The dryer optionally comprises a temperature sensor (135) for sensing the temperature of the air.", "If the conducted air is not heated beforehand, it may be heated with one or more heating elements (134) in the body (131).", "Moist air, which rises from the process area of the dryer, can be captured and removed from the process area by an evacuation system (136).", "The alternate liquid removal system (140, FIG.", "17) comprises one or more heating elements (141) superposing the drying process area and/or one or more heating elements (142) embedded within the build module in a location thermoconductively adjacent to the cavity.", "The 3DP equipment assembly/apparatus of the invention can be provided in varying embodiments.", "FIG.", "18 depicts an assembly/apparatus (145) comprising a powder layering region/system (Z-1), first punch region/system (Z-6), printing region/system (Z-2), drying region/system (Z-3), discharge region/system (Z-4), drive motor/system (157), height adjuster (154), combination rotary conveyor and build module system (146, 147) with plural cavities (149), and stationary body (148).", "The first punch system comprises an upper punch (150) and a lower punch (159).", "The system also comprises a second lower punch (158) that discharges 3DP articles from their respective cavities by pushing them upwards so that a push mechanism (161) can direct the 3DP article to the chute (156).", "The drive motor drives the conveyor which conducts cavities from one region to another.", "The height adjuster (154) adjusts the height of the height adjustable platform in each cavity.", "FIG.", "19 depicts a partial sectional side view of the combination rotary conveyor and build module system (146, 147) with a respective cavity (163), the height adjuster (154), and a lower rotary drive (171).", "As the conveyor (147) rotates, it rotates the build modules (146) engaged to it.", "In this particular embodiment, the build module comprises a height adjustable platform (168) having a threaded body (169) engaged with a complementarily threaded nut (165) and with a complementarily threaded bore (162) of the conveyor (147).", "The outer perimeter of the nut (165) briefly contacts the foot or wheel (166) of the height adjuster (154), thereby rotating the nut and causing the height of the platform (168) to lower (Arrow M) with respect to the upper surface of the build module.", "Alternatively, the platform can be raised (Arrow N) or lowered (Arrow M) by rotating the nut (165) in the required direction with the height adjust (154) or by engaging the bottom of the threaded body (169) with the lower rotary drive (171), which is rotated (Arrow O or Arrow P) in the required direction.", "The powder layering system typically comprises a powder spreader, powder feeder and powder reservoir.", "FIG.", "20 depicts a powder layering system (175) comprising a reservoir (176), feeder (177), hopper (178), and body (181), which also serves as a spreader.", "The powder layering system forms a layer of powder in a cavity by dropping powder from the hopper into the cavity.", "The spreader spreads the powder, if needed, in the cavity and also removes excess powder from the cavity.", "FIG.", "21 depicts a top plan view of an alternate powder layering system (185) comprising a support (187), hollow body or shroud (186) within which a paddle wheel spreader (189) is disposed.", "During use, powder charged into the hopper (188) is dropped into the spreader, which drops powder into a cavity beneath the spreader.", "The spreader spins to remove excess powder from the cavity and smooth the surface of the powder in the cavity.", "Cavities (C-1 to C-8) are repeated filled in this manner.", "The equipment assembly/apparatus (195) of FIG.", "22 comprises a drive system (208) that spins/rotates the combination conveyor and build module system (200) such that its cavities are conducted beneath the powder layering system (201), printing system (204), drying system (205) and punch system (195).", "The powder layering system has a reservoir (202) that can be charged through a port (203) in the cover (197) of the assembly/apparatus (195).", "The cover is supported by supports (198) that are mounted onto a stationary platform (199).", "The drying system includes an evacuation system that removes moist air from the drying area through a tube and out through a port (206) in the cover (197).", "3DP articles are discharged from cavities to a chute (209) that directs the articles further downstream in the process, e.g.", "for drying or dedusting.", "Various components are computer (207) to synchronize their operation.", "A build lap with the assembly/apparatus (195) requires a single complete revolution of the conveyor such that a 3DP article comprising 10 incremental printed layers would required 10 build laps (10 revolutions) of the conveyor.", "However, the various components of the system can be arranged as needed to provide the desired process steps with respect to revolutions of a conveyor.", "The assembly/apparatus (210) of FIG.", "23 plural process stations (enclosed in dashed lines), each station comprising in sequence a powder layering system (214), a printing system (215), a drying system (216), and a punch system (217).", "This assembly comprises at least ten process stations (five shown and five not shown) arranged sequentially along the length of the conveyor (212).", "This means that only a single revolution of the conveyor (driven by the drive system (211)) would be required to prepare a 3DP article comprising ten incremental printed layers.", "This assembly also comprises a lower punch beneath each cavity, but only comprises ten upper punches above the cavities.", "In other words, the assemblies of the invention can comprise less upper punches than lower punches, meaning they can comprise partial and full punch systems.", "The assembly/apparatus (220) of FIG.", "24 differs from that of FIG.", "23 in that each process station comprises in sequence a powder layering system (214), a punch system (217), a printing system (215), a drying system (216), meaning that the punch system has been placed in a different operational order with respect to the one of FIG.", "23.Moreover, this optional embodiment does not require a lower punch beneath each cavity, since the lower punches (221) are only located beneath the upper punches (217).", "The other lower punches are optional.", "However, this assembly still comprises ten process stations (five depicted, five not depicted) The assembly/apparatus of FIG.", "25 comprises eight process stations, each comprising in order a powder layering system, a first punch system (228), a printing system, a drying system, and a second punch system (227).", "As in FIG.", "24, this assembly does not require a lower punch beneath each cavity.", "FIG.", "26 includes a more detailed partial sectional side elevation view of the assembly (230) comprising an upper punch system (231), upper punch drive (232), upper punch (233), support (234), platform (235), base (236), conveyor drive (244), conveyor (240), build module (241), cavity (242), lower punch drive (240), lower punch (245), lower punch actuator (237), and coupling (238, 243).", "The build module can be a bushing, shaft, collet, sheet, die or other similar device such that a conveyor will comprise plural such devices each having a cavity therein.", "The build module is placed within a seat (239) in the conveyor.", "The upper and lower punches are aligned with each other and the cavity.", "In this embodiment, the lower punch is substantially equivalent to a height adjustable platform within the cavity.", "During operation, the cavity is placed between the punches.", "The upper punch drive (232) raises and lowers (Arrow Q) the upper punch (233).", "The lower punch drive (240) raises and lowers (Arrows R) the lower punch (245) after the actuator (237) has coupled with the drive (240) by laterally (Arrow T) engaging the shaft (238) with the coupling (243).", "In an alternate embodiment, the lower punch drive (240) is removed and the actuator (237) engages with the lower punch and then raises and lowers the punch directly.", "Assemblies/apparatuses of the invention comprising plural build stations are particularly suitable for preparing 3DP articles comprising incremental layers differing in composition.", "In some embodiments, a 3DP article comprises: a) at least a first incremental printed layer comprising a first bulk powder, and at least a second incremental printed layer comprising a different second bulk powder; b) at least a first incremental printed layer comprising a first composition, and at least a second incremental printed fluid comprising a different second composition; c) at least a first incremental printed layer comprising at least one component from a first binding fluid, and at least a second incremental printed fluid comprising at least one different component from a second binding fluid; or d) a combination thereof.", "The invention also provides a process for preparing a 3DP article comprising at least a first incremental printed layer comprising a first composition and at least a second incremental printed layer comprising a different second composition, the process comprising: a) forming at least one first incremental printed layer; and b) forming at least one second incremental layer, wherein: 1) bulk powder used to form the first incremental printed layer is different from the bulk powder used to form the second incremental printed layer; 2) printing fluid used to form the first incremental printed layer is different from printing fluid used to form the second incremental printed layer; or 3) a combination of 1) and 2), and wherein there is no substantial excess of one or more bulk powders surrounding a 3DP article when formed.", "FIG.", "27 depicts a top plan view of an alternate assembly/apparatus (250) of the invention comprising a body (251), conveyor (252) with plural build modules and respective cavities (253, some depicted in dashed lines), a support system (254), discharge system (260) and plural build stations (261, exemplary one encircled in dashed line), which build stations comprise powder layering systems (256), printing systems (257), in-process layer drying systems (258), and punch systems (259).", "The assembly/apparatus (250) comprises four build stations.", "In this embodiment, a single cycle of the conveyor provides four build laps.", "The bulk powder in each respective build station can be the same or different than that of another.", "The binding fluid in each respective build station can be the same or different than that of another.", "If desired, this assembly/apparatus can be used to prepare 3DP articles comprising two, three, four or more incremental printed layers differing in composition.", "FIG.", "28 depicts a top plan view of an alternate assembly/apparatus (265) comprising a cyclic conveyor (266), plural build modules with respective cavities (not depicted), at least one discharge system comprising a discharger (274) and chute (273), and plural build stations (267, 268), each comprising a powder layering system (269), printing system (270), in process layer drying system (271), and punch system (272).", "In this embodiment, a single cycle of the conveyor provides two build laps.", "The bulk powder in each respective build station can be the same or different than that of another.", "The binding fluid in each respective build station can be the same or different than that of another.", "If desired, this assembly/apparatus can also be used to prepare 3DP articles comprising two or more incremental printed layers differing in composition.", "FIG.", "29 depicts a top plan view of a portion of an alternate assembly/apparatus (275) comprising a linear conveyor (276), plural build modules with respective cavities (not depicted), at least one discharge system comprising (not depicted), and plural build stations (277, 278), each comprising a powder layering system, printing system, in process layer drying system, and punch system.", "Build modules are conducted sequentially through build stations (Arrow V).", "The bulk powder in each respective build station can be the same or different than that of another.", "The binding fluid in each respective build station can be the same or different than that of another.", "If desired, this assembly/apparatus can also be used to prepare 3DP articles comprising two or more incremental printed layers differing in composition.", "FIG.", "30 depicts a top plan view of an alternate assembly/apparatus (280) comprising a reciprocating (oscillating) conveyor (281), plural build modules with respective cavities (not depicted), at least one discharge system comprising a discharger (285) and chute (284), and plural build stations (282, 283), each comprising a powder layering system, printing system, in process layer drying system, and punch system.", "In this embodiment, the conveyor conducts build modules back and forth (Arrows W and X) through the build stations.", "The bulk powder in each respective build station can be the same or different than that of another.", "The binding fluid in each respective build station can be the same or different than that of another.", "If desired, this assembly/apparatus can also be used to prepare 3DP articles comprising two or more incremental printed layers differing in composition.", "FIG.", "31 depicts a top plan view of a portion of an alternate assembly/apparatus (290) comprising a conveyor (291), plural build modules with respective cavities (not depicted), at least one discharge system (not depicted), and at least one build station (292) comprising at least two powder layering systems (293), at least two printing systems (294), at least one process layer drying system (295), at least one punch system (296) and at least one discharge system (297, 298).", "Build modules are conducted through the first powder layering system to the first printing system to the second powder layering system to the second printing system and to the layer drying system.", "Another punch system (not depicted) can be placed between the first printing system and the second powder layering system.", "In such case, build modules are conducted through the first powder layering system to the first printing system to the first punch system to the second powder layering system to the second printing system and to the layer drying system.", "FIG.", "32 depicts a top plan view of an alternate assembly/apparatus (300) comprising a modular conveyor (301), plural build modules with respective cavities (not depicted), at least one discharge system (313, 314)), at least two build stations (302, 303), at least two build module transfer means (310-312, 316-318).", "The build station comprises a powder layering system (304), a printing system (305), a first punch system (306), a process layer drying system (307), and a second punch system (308).", "With a first portion of the conveyor, build modules are conducted (Arrow Y) through each system of one build station and then transferred to another portion of the conveyor using the transfer means.", "Completed 3DP articles are discharged with the discharge system and a punch system (315).", "A single conveyor cycle thus provides two build laps.", "The assembly/apparatus (320) of FIG.", "33 (side elevation view) provides vertical displacement of build modules (325a-325e) using a combination linear and cyclic (Arrow Z) modular conveyor.", "Modules (325a) are loaded into the cyclic portion of the conveyor and through the powder layering system (321), printing system (322), layer drying system (323) and punch system (324) of the build station (326).", "The modules are then displaced vertically (325b) and cycled (325c, 325d) back to the entry point of the build station.", "Upon completion of printing, modules (325e) are conducted away from the build station.", "The invention thus provides a 3DP assembly/apparatus comprising a combination modular (segmented) conveyor system comprising at least one linear region and at least one cyclic region.", "A single conveyor cycle thus provides one build lap.", "FIG.", "34 depicts a top plan view of an alternate assembly/apparatus (330) of the invention comprising a body (331), a conveyor (332) with plural cavities (333), drive means (340) for advancing the conveyor from one position to the next, a computer controller (341), discharge system (339), and two build stations, each comprising a powder layering system (334), printing system (335), drying system (336), and punch system (337).", "The system further comprises one or more inspection systems (338) for in-process monitoring features of the incremental powder layers and/or printed layers.", "A single conveyor cycle thus provides two build laps.", "The bulk powder in each respective build station can be the same or different than that of another.", "The binding fluid in each respective build station can be the same or different than that of another.", "If desired, this assembly/apparatus can also be used to prepare 3DP articles comprising two or more incremental printed layers differing in composition.", "A discharger (discharge system) can comprise substantially any means for moving a solid material from one location to another, especially a system adapted for removing solids from a conveyor.", "A discharger can comprise a rod, bar, plate, diverter, or other fixed or articulated moving means for lifting or pushing or otherwise transferring articles so as to exit one section of an apparatus, system, or component, and optionally to enter another.", "In a first position, a discharger does not direct articles away from the build system and in a second position it does.", "3DP articles are further processed downstream from the build system.", "FIG.", "35 depicts a generalized sequence of process areas/systems (345) comprising a 3DP article collection system (346), a 3DP article drying system (347), a 3DP article dedusting system (348) and a 3DP article packaging system (349).", "Each of these systems can process one or more articles at a time.", "Although the depiction of a 3DP article collection system (346) implies gravimetric filling of a bulk container, this depiction is only symbolic, as all other collection means are contemplated and may be deployed in analogous sequence to that shown in FIG.", "35.FIG.", "36 depicts a top plan view of an exemplary multi-cavity three-dimensional printing equipment assembly (350) comprising a conveyor (351) that conducts plural build modules (355) engaged with the conveyor system along a predetermined path through build regions in one or more build stations, respectively, comprising: a) at least one powder layering system (352) that forms incremental powder layers within build modules; and b) at least one printing system (353) that deposits a liquid (binding fluid) according to a predetermined pattern to incremental powder layers within build modules.", "The build modules receive and temporarily retain powder from the powder layering system.", "The cyclic conveyor system forms a continuous loop system that repeatedly transports/cycles the build modules from the at least one powder layering system to the at least one printing system to form a 3DP bed or form one or more 3DP articles in the cavities of the build modules.", "The exemplary conveyor system comprises at least one drive (358) and plural conveyor modules (351a), thereby forming a segmented or modular conveyor system.", "A conveyor module is engaged with a corresponding build module and conducted along a predetermined pathway in the direction of Arrow A1.The equipment assembly in FIG.", "36 is depicted finishing printing of a first batch of 3DP articles, via a cavity 3DP process, and starting the 3-D printing of a second batch of 3DP articles.", "The just-completed 3DP articles from the end of a first build cycle are in build module (351a), and the beginning of the second batch starts with a printed incremental layer in build module (355L).", "Build module (355a) includes six 3DP articles, each in its respective cavity.", "In cavity 3DP, the top plan view of the 3DP articles approximates the top plan view of the respective cavities, which in this particular embodiment are depicted as square-shaped.", "As the build modules (355, 355a-355L) are conducted along the predetermined course, they pass through the article transfer system (357), which transfers build modules and completed 3DP articles or just completed 3DP articles, one or more at a time, away from the 3DP build system.", "A build module comprises a body (356a), and upper surface (356c) having plural cavities within each of which a height adjustable build platform (356b) is disposed.", "The build module (355h) is now ready to receive powder.", "The build module (355j) is depicted passing through the powder dispensing region of a powder layering system.", "The build module (355k) is depicted between the powder layering system and the printing system.", "The build module (355L), which is the first build module of the next build lap, is depicted passing through the printing region of the printing system.", "A control system, comprising at least one or more computers and one or more use interfaces (354), can be used to control and integrate (coordinate) operation of the various components and systems of the equipment assembly.", "In some embodiments, operation of each of the conveyor system, the height adjustable platforms of the build modules, the at least one powder layering system, and the at least one printing system are controlled by the control system.", "In some embodiments, operation of the bed transfer system is controlled by the control system.", "An equipment assembly can further comprise an article and/or build module transfer system (357) that transfers 3DP articles (and optionally corresponding build modules), one or more at a time, away from the 3DP build system.", "The exemplary transfer system simultaneously removes two or more 3DP articles or build modules in an article transfer region.", "In some embodiments, a three-dimensional printing equipment assembly comprises: a) a three-dimensional printing build system comprising: a conveyor system adapted to conduct plural build modules; plural build modules engaged with the conveyor system, wherein the build modules can receive and temporarily retain powder from a powder layering system, and wherein each build module comprises one or more cavities; and at least one build station comprising: 1) at least one powder layering system adapted to form incremental powder layers within build modules temporarily disposed in a powder dispensing region of the build station; and 2) at least one printing system adapted to apply a liquid according to a predetermined pattern to incremental powder layers temporarily disposed within build modules in a printing region of the build station; wherein the conveyor system repeatedly transports the build modules from the powder dispensing region of the at least one powder layering system to the printing region of the at least one printing system to form one or more 3DP articles in the build modules; b) at least one article (and/or build module) transfer system that transfers completed 3DP articles (and/or build modules), one or more at a time, away from the build region of the 3DP build system; c) at least one control system that controls operation of one or more systems of the equipment assembly; d) optionally, at least one liquid removal system; and e) optionally, at least one packaging system adapted to package one or more 3DP articles at a time.", "A build module receives and retains powder deposited therein by a powder layering system.", "In some embodiments, the build module comprises a height adjustable platform (or lower punch) disposed within a cavity in the upper surface of the build module, wherein the cavity is defined by sidewalls and edges.", "The height adjustable platform in combination with the sidewalls forms a cavity for the powder.", "The platform raises or lowers incrementally.", "Powder is placed within the cavity and onto the platform.", "FIG.", "37 depicts an exemplary build module (365) comprising a body (361), one or more cavities (362), and height adjuster (364) engaged with and adapted to raise and lower one or more height adjustable platforms (punches) (365) disposed in the respective cavities.", "A build module can be permanently or removably engaged with the conveyor system.", "Although the body and cavity of the build module are depicted having a rectangular shape, they can be shaped as needed.", "In a cavity 3DP system, the top plan view of the cavity approximates the plan view of an 3DP article to be printed in the cavity.", "The height adjuster can comprise one or more height adjusters.", "In some embodiments, the height adjuster is incrementally height adjustable thereby rendering the height adjustable platform also incrementally height adjustable.", "In some embodiments, an incrementally height adjustable component or system is raises by one or more increments before and/or after placement of a layer of powder on a build module and prior to placement of a subsequent layer of powder the build module.", "The height of an increment (thus the thickness of an incremental layer) can be controlled in different ways.", "In some embodiments, the height adjuster is computer controlled, whereby the computer controls raising or lowering of the height adjusting means by the size of an increment and/or by the number of increments.", "The size (height, vertical displacement) of an increment can vary from incremental layer to incremental layer, be the same from incremental layer to incremental layer or a combination thereof.", "In some embodiments, the size of the increment is the same for each incremental layer (build lap) of a build cycle, is different for one or more incremental layers of a build cycle, or a combination thereof.", "The size of a vertical increment can be relative to a prior initial position of the build platform or the height adjuster of the powder fill head or both.", "For example, the platform is lowered within the cavity by a first increment to a first position relative to upper surface of the build module.", "A printed incremental layer is formed on the platform at the first position during a first build lap.", "The platform is then lowered by a second increment to a second position but relative to where it was at the first position.", "Another printed incremental layer is formed on the platform while at the second position during a second build lap.", "This process is repeated until completion of a build cycle.", "The size of a vertical increment can be relative to one or more absolute positions of the platform in the cavity of a build module.", "For example, the build module can comprise plural encoders distributed vertically within or adjacent the cavity.", "The size of a first vertical increment, then, is defined by the absolute position (absolute vertical distance) of the platform with respect to a first encoder.", "When the platform is lowered by a second increment to a target second vertical position, which is determined according to or defined by the absolute vertical distance of the platform with respect to a second decoder.", "This type of absolute positioning can be exemplified as follows.", "If the target increment is 0.50 mm below the upper surface of a build module, the platform is commanded to drop 0.50 mm.", "If the next target increment is to be an additional 0.25 mm, then the platform is commanded to drop to a depth of 0.75 mm below the upper surface of the build module rather than to command it to drop by 0.25 mm relative to the initial 0.5 mm increment.", "This approach is generally superior to using relative moves (0.500, then 0.250) as any minor positioning errors will be resolved or at least not accumulate.", "The height of an increment can also be controlled by the relative vertical displacement of the lower and/or upper punch of a punch system.", "In some embodiments, the upper and lower punches (platform) are lowered the same distance in the same direction, wherein the vertical distance corresponds to the height of the increment.", "In some embodiments, the upper punch is lowered a first distance and the lower punch is lowered a second distance, wherein the first distance is greater than the second distance such that the difference in distances corresponds to the height of an increment.", "In some embodiments, the upper punch is lowered a first distance and the lower punch is lowered a second distance, wherein the first distance is greater than the second distance, and both lower and upper punch are subsequently raised such that the height of an increment corresponds to the net change in vertical distance moved by the lower punch.", "In some embodiments, one or more vertical movements may be made by the upper and lower punches, and the height of the increment corresponds to the relative vertical distance from the top surface of the solid material in the cavity to the height of the top surface of the sidewalls of the cavity.", "In some embodiments, the height (thickness) of an incremental layer is equal to the vertical distance between the top of the cavity and the top of solid material (i.e.", "prior powder layer or prior incremental layer) in the cavity.", "The height of the platform (or lower punch) within a cavity can be controlled, changed or adjusted with a servo motor or other such means.", "The exemplary powder-layering system (381) depicted in FIG.", "41 is mounted on a support (table, frame, body, 384) and comprises at least one powder fill head (381), at least one powder reservoir (387) and at least one powder feeder tube (383) driven by a powder feeder drive (384).", "It transfers powder from the powder reservoir to the powder fill head.", "The powder feeder tube can comprise a drive motor and screw-type shaft, e.g.", "an auger or shaft with spiral blades/vanes, such as found in a Schenk feeder.", "The powder-layering system supplies powder to, and optionally forms, the incremental powder layer when a build module passes through the powder dispensing region (386, also referred to as a layering region).", "In some embodiments, a powder fill head comprises a powder fill head body, at least one powder fill head hopper and at least one powder spreader.", "The hopper receives material from the powder feeder tube to form a temporary supply of powder, which is optionally agitated by powder fill head agitator, which can be a powder fill head distribution plate instead.", "In some embodiments, the hopper is replaced with a chute (not shown, or distribution plate) having a channeled interior surface that distributes powder evenly across the width of the surface and downward onto a build module.", "In some embodiments, the powder fill head further comprises at least one powder-height controller adapted to control the relative distance between the powder spreader and a surface (such as the upper surface of the build module, the height adjustable platform, or a prior powder layer) below the powder spreader.", "An optional distribution bar (or plate, not shown) can be placed between the outlet of the fill head body and the powder spreader (roller).", "The distribution bar serves to better distribute powder across a layer of powder prior to being contacted by the powder spreader, whereby an incremental powder layer is formed.", "The powder-height controller can raise or lower the powder spreader so as increase or decrease the thickness of a layer of powder placed onto the platform (lower punch) or a prior layer of powder on the platform.", "For example, if the platform (lower punch) is lowered by a first increment and the powder-height controller is raised by the same or another second increment, then the thickness of powder laid down will approximate the sum of the first and second increments.", "If the platform is lowered by a first increment and the powder-height controller is lower by a second increment, then the thickness of powder laid down will approximate the difference of the first increment minus the second increment.", "Alternatively, the powder spreader in combination with the powder-height controller can cooperate to compress a layer of powder that has been previously laid down.", "This can be accomplished by first laying down a layer of powder having a first thickness during a first build lap, lowering the powder-height controller and powder spreader and then passing the layer of powder under the lowered powder spreader thereby compressing the layer of powder.", "In some embodiments, the powder spreader is a cylindrical roller the axis of which has a radial direction of motion opposite the linear direction of motion of a build module through the powder layering system.", "For example, the surface of the cylinder has a first linear direction opposite the second direction by which an underlying build module passes under the cylinder.", "In some embodiments, the powder spreader is a cylindrical roller, bar, rod, plate or straight smooth edge.", "Powder fill heads of other construction can be used.", "The amount or rate of powder discharged from the powder fill head can be regulated with one or more controls.", "A powder discharge feedback controller can monitor the accumulation of powder at the powder spreader as the powder is being discharged from the powder fill head and spread to form an incremental powder layer.", "If the rate at which powder is released is too fast, an excessive amount of powder will accumulate at the powder spreader possibly causing it to spread the powder improperly.", "The feedback controller then sends a signal thereby causing the rate of powder discharge from the powder fill head to decrease.", "Conversely, if the feedback controller senses that the rate of powder discharge is too slow, it sends a signal thereby causing the rate of powder discharge to increase.", "The feedback controller can employ one or more visual, laser, acoustic or mechanical sensors or a combination thereof.", "Other control approaches may be used, such as gravimetric control from a source of powder supply, either alone or in conjunction with the approaches above.", "A conveyor module comprises a body, engagement means (male and/or female) and one or more build module engagement means adapted to removably or permanently engage build modules.", "In some embodiments, adjacent segments (modules) of the conveyor are pivotally engaged by means of engagement means such that the segments can pivot about an axis.", "Although engagement means can be a hinge-type joint, other engagements can be used.", "FIG.", "42 depicts a perspective view of a powder layering system (390) depositing bulk powder into the individual cavities (394) of a build module comprising plural cavities.", "Bulk powder is charged into the hopper (391) by means of a conduit (392).", "The layering system deposits powder into the cavities, but the system can optionally further comprise a powder removal system that removes excess powder from the upper surface of the build module, thereby leaving behind loose powder only in the cavity(ies) of the build module.", "FIG.", "43 depicts a top plan view of a partial build station comprising a powder fill head (397) and a print head (399) below which is a conveyor module (395) and corresponding build module (396) moving in the direction of Arrow Q1 through a powder dispensing region and a printing region, respectively.", "The fill head, which is disposed transverse to the direction of motion of the build module, which comprises plural cavities, remains transversely and longitudinally stationary (with respect to the plane defining the upper surface of the build module, even though it can move vertically toward or away from said plane) as it places an incremental layer of powder (401) into and across the width of one or more cavities.", "The fill head (397) comprises a spreader (398 depicted in dashed line) and hopper.", "The build module moves in the direction of Arrow Q1, whereby it passes through the printing region beneath the print head (399) and print module (400), which are disposed transverse to the direction of motion of the build module.", "The print head remains transversely, longitudinally and vertically stationary with respect to the plane defining the upper surface of the build module.", "The print module applies liquid onto the incremental layer of powder according to a predetermined pattern, thereby forming an incremental printed layer (402) in respective cavities.", "The exemplary print head comprises a single print module (400; depicted in dashed line) that spans the width of a cavity of the build module.", "FIG.", "38 depicts an exemplary printing system that applies liquid (binding fluid) to a powder layer in the printing region of the printing system.", "In some embodiments, the liquid is applied according to a Cartesian coordinate system or according to a polar coordinate system (radial system, cylindrical coordinate system, circular coordinate system, or spherical coordinate system).", "An exemplary printing system comprises at least one print head (372), which deposits liquid onto an incremental layer of powder in a build module, and at least one liquid feed system that conducts liquid from one or more liquid reservoirs to the at least one print head.", "In some embodiments, the printing system comprises plural print heads, plural liquid feed systems, plural reservoirs or a combination thereof.", "In some embodiments, the printing system comprises a single print head, plural liquid feed systems, and plural reservoirs.", "The print head of FIG.", "38 directs a stream of droplets of liquid into a printing region (374) through which build modules pass.", "The exemplary system comprises a frame or gantry (371) by way of which the print head (372) can translate/move in the direction of Arrow D1, which is transverse to the direction of motion of a build module during printing.", "The printing system can be mounted to a support (373).", "Translation of the print head can be performed manually or via computer controlled operation.", "In some embodiments, the print head is stationary when applying liquid onto an incremental layer of powder, meaning that as liquid is being applied to a powder layer during a print lap, the print head (in particular the print modules) does not move in a direction which is transverse, with respect to the build plane, to the direction of motion of a build module during printing, i.e.", "during the application of liquid.", "Such a means of printing is different than prior systems wherein the print head (in particular the print module(s)) moves back and forth, in a direction which is transverse to the direction of motion of a build module, during printing.", "A print head can comprise one or more print modules that deposit the liquid onto a layer of powder.", "The print head can comprise plural print modules that form corresponding printing regions.", "When a print head comprises plural print modules, the arrangement/layout of the print modules can be as needed.", "The print head (375) of FIG.", "39 comprises plural print modules (376) arranged in plural columns with each column comprising plural print modules.", "A powder can pass across the print modules in the direction of Arrow E1 such that the print direction is transverse to the horizontal shape of the print module.", "Other suitable arrangements for the print modules are depicted in FIG.", "40.The print head (379) comprises a single print module.", "The print head (380) comprises four print modules pared in groups (380a, 380b) of two offset horizontally from one another.", "The print head (378) is somewhat similar to head (380) except that the print modules (380a, 380b) are wider horizontally and offset to a greater extent horizontally than are the print modules (378a); moreover, the print modules are horizontally offset from one another.", "The print head (377) comprises two linearly and transversely offset groups (377a, 377b) of print modules.", "When viewed in the direction of Arrow E1, the adjacent edges of the two groups overlap (each group overlaps the dashed line).", "By offsetting the print modules as depicted for module (378), the apparent overall print resolution of the print head can be increased.", "The print modules can be offset in staggered, interlaced, sabered, or angled arrangements relative to the print head in order to increase overall print density/resolution.", "For example, if the print resolution of each print module is 75 dpi (drops per inch), then the apparent overall print resolution of the print head (378) can be 75 dpi, 150 dpi, 225 dpi, 300 dpi, 375 dpi, 450 dpi or even higher.", "If the print resolution of each print modules is 100 dpi, then the apparent overall print resolution of the print head (378) can be 100 dpi, 200 dpi, 300 dpi, 400 dpi or even higher.", "In some embodiments, the print resolution of the print head is the same as or greater than the print resolution of a print module comprised within the print head.", "In some embodiments, the print resolution of the print head is a multiple of the print resolution of one or more print modules comprised within the print head.", "In some embodiments, the print resolution of the print head is the less than the print resolution of a print module comprised within the print head.", "The arrangement of one or more print modules in the print head can be modified as needed to provide the desired printing result.", "The print head (405) depicted in FIG.", "44A comprises four print modules (406) arranged in both transverse and longitudinal displacement (with respect to the direction of motion of the print head).", "Together the four print modules span the width of the cavity of the build module.", "The embodiment (407) of FIG.", "44B differs from that of FIG.", "44A in that the four print modules (408) are only transversely displaced but not longitudinally displaced.", "In some embodiments, the one or more print heads is/are stationary when applying liquid onto an incremental layer, i.e.", "when printing.", "The one or more print heads can, in particular, be transversely and longitudinally stationary, with respect to the linear direction of motion of a build module (and thus an incremental layer of powder), when printing.", "Particular embodiments include those wherein: a) the printing is performed according to a Cartesian coordinate algorithm; b) the build module moves during printing in a linear direction that is perpendicular to the disposition of the print module (and one or more print heads); c) the print head and one or more print modules are stationary when printing (when applying liquid to an incremental layer of powder) and do not move in a direction that is transverse or longitudinal with respect to the direction of motion of the build module; and/or d) printing is performed according to a polar coordinate algorithm.", "The three-dimensional printing system/assembly of the invention employs Cartesian coordinate and/or polar coordinate based printing system and algorithms.", "Unlike other systems that move the print heads transversely and/or longitudinally when printing, the print heads of the invention can be (but need not be) substantially stationary during printing.", "The term “transversely” is determined in relation to the direction of motion of a build module beneath a print head and means substantially perpendicular to the direction in which a build module is conducted through a printing area.", "The term “longitudinally” is determined in relation to the direction of motion of a build module beneath a print head and means substantially parallel to the direction in which a build module is conducted through a printing area.", "Application of liquid across the width of powder layer beneath a print head is accomplished by employing one or more print modules that individually or together traverse at least 75%, 80%, at least 85%, at least 90%, at least 95%, at least 97.5% or at least 99% the width of the powder layer.", "In the present case, the “width” of the powder layer is determined along a direction transverse to the direction of motion of a build module beneath a print head, and the term “length” is determined along a direction parallel to the direction of motion of a build module beneath a print head.", "In other words, a single print head can traverse the width or plural print heads transversely adjacent to each other can traverse the width of the powder layer.", "In particular embodiments, the print head comprises plural print modules that individually do not, but together do span the width of an incremental powder layer and/or of the cavity of a build module.", "In some embodiments, one or more print modules together span at least 50%, at least 55%, at least 75%, at least 90%, at least 95%, at least 99% or all of the width of the cavity of the build module.", "In particular embodiments, the build module moves in a first direction, and the print head is stationary when liquid is being applied to the incremental powder layer.", "In particular embodiments, printing is performed primarily or solely according to a Cartesian coordinate algorithm.", "For example, the algorithm controls application of the droplets of the printing fluid relative to the linear (non-radial, straight) direction of the conveyor such that the print head applies droplets in a direction that is parallel (longitudinal) or is perpendicular (transverse) with respect to the linear direction of motion of the conveyor.", "The conveyor and corresponding build modules only move in a straight linear direction beneath the print head and build head.", "An alternate embodiment of the invention is depicted in FIG.", "44C, wherein the print head (409) comprises one or more or plural print modules that do not span the width of an incremental powder layer and/or of the cavity of a build module.", "This print head is either stationary when printing (when applying liquid to an incremental layer of powder) or moves transversely, with respect to the direction of motion of the build module, while applying liquid to the powder.", "The print modules of the print heads (377, 378, 380, 409 of FIGS.", "40 and 44C) are arranged such that the jets on multiple print heads are interleaved to increase the print density across the print bed.", "For example, individual print modules having a native print density of 100 dpi are interleaved together such that four of the print heads together provide a 400 dpi print density.", "In some embodiments, clusters of print modules, such as depicted in FIG.", "44D, are arranged so their overall span covers only part of the width of a powder layer, such that plural print heads (each containing a cluster of print modules with interleaved jets) are required to cover the full width of the powder layer.", "For example, three print heads (410), each having a cluster of print modules which together spans only 2.5″, would need to be arranged in a horizontally offset manner in order to cover the width of a powder bed or layer that is between 5 to 7.5 inches wide.", "The at least one printing system can apply liquid according to any predetermined print pattern or randomly onto an incremental layer of powder.", "The pattern can be the same from incremental layer to incremental layer or can be different for one or more incremental layers of a printed article.", "Generally, two adjacent print patterns (i.e., vertically neighboring within the same 3DP article design) will comprise at least two overlapping printed portions such that at least a portion of the printed/bound powder in one printed incremental layer will adhere (be bound) to at least a portion of the printed/bound powder of an adjacent printed incremental layer as one is formed atop the other.", "In this manner, plural stacked adjacent printed incremental layers adhere to each other thereby forming a three-dimensionally printed article comprising plural adjacent printed incremental layers of completely or partially bound powder.", "Even though a three-dimensionally printed article can include undercuts, overhangs, cavities, holes and other such features, at least part of the printed portions of adjacent printed incremental layers must adhere to one another in order to form and fill the composite volume of the article.", "The printing system employs Cartesian coordinate-based and/or polar coordinate-based printing algorithms when applying liquid to an incremental powder layer.", "The system includes a computer and associated software that comprises one or more print jobs.", "A print job includes, among other things, information on the thickness of incremental layers and the predetermined pattern to be printed on the incremental layers of a printed article.", "The print job provides layer-by-layer instructions to the print head (print module(s)) about the creation and placement of droplets of liquid onto the incremental powder layer.", "The print job is based upon the series of two-dimensional images (slices) that, when stacked, together form a predetermined three-dimensional image (object).", "Without being held bound to a particular mechanism, a target three-dimensional article is designed, such as with a CAD program.", "A virtual image of the target article is sliced virtually into plural stacked thinly-sliced images (which are referred to herein as “two-dimensional” images), wherein each two-dimensional image is actually the thickness of an incremental powder layer.", "The sum total of thicknesses of the image slices equals the total “height” of a target article.", "Each two-dimensional “image” is then converted into a subset of printing instructions, which together define a predetermined printing pattern for that image.", "All of the subsets of printing instructions are joined together to form a final set of printing instructions that are used by the computer to control printing.", "Aside from incremental layer thickness, two-dimensional shape of predetermined patterns, and shape of target article, the final set of print instructions also includes specification of or consideration of linear speed of the build module beneath the print head, rate of application of liquid to incremental powder layers, length and width of the incremental powder layer, dimensions of the cavity of a build module, incremental height adjustment of the height adjustable platform of the build module, rate of loading of powder into the powder fill head, rate of loading of powder into a build module to form an incremental layer, rate of transfer of powder from a feed reservoir to the fill head, resolution of the two dimensional image to be printed on each incremental layer, the number of applications of liquid to each incremental layer, application of one or more specific liquids to one or more specific locations of the incremental layer, starting and stopping of liquid application with respect to each build module, the number of articles to be printed, the number of build modules in the equipment assembly, the number of build modules to be printed upon, rate at which the platform of the build module moves down, timing for starting and stopping powder delivery relative to the entire build cycle, rotational speed of leveling device (roller) and other such parameters.", "An equipment assembly comprises a control system comprising one or more controllers.", "Without being held bound to a particular mechanism, a homing switch located at a fixed point of the conveyor provides a reference point as to the location of the “first” build module in a group of build modules.", "From there, a computer is able to determine the location of the rest of the build modules in that group by knowing the size of the conveyor, the spacing of the build modules and the dimensions of the build modules.", "The control system can also comprise a proximity sensor that specifies the location of one or more build modules relative to the conveyor.", "The control system comprises a synchronizer that facilitates synchronization of operation of the various components of the equipment assembly.", "By taking into consideration the track (linear) speed of the conveyor and the target thickness and width of an incremental layer, a computer is able to instruct the powder layering system to charge powder onto the build modules at a certain feed rate.", "After part of a lap or after one or two calibration laps, the powder feed rate can be continuous.", "Once a proper incremental powder layer is formed, deposition of liquid onto the incremental layer can begin.", "A proximity sensor senses the leading edge of a build module and then sends instruction to the print system.", "A computer controlling the print system takes into consideration a set of printing instructions (which can include among other things the target print resolution (density), the image(s) (pattern(s)) to be printed on the incremental layer, the target rate of liquid deposition, the number of liquids to be deposited, the dimension of the print head and print modules, track speed, the set of images (patterns) that are to be printed to form a target 3D printed article, target article porosity or density, or other such parameters) and the signal generated by a wheel encoder, for example, to provide a pulse that sets the print rate at which to consume the image files in the printing instructions and the resolution at which to print the image file(s).", "Following completion of layering and printing per the printing instructions, a build cycle is completed.", "As described herein, the powder system can comprise one or more feedback controllers that determine the proper powder feed rate into a powder feeder and into the build modules.", "Likewise, the printing system can comprise one or more feedback controllers that determine the rate at which printing fluid (liquid) is being applied and/or consumed and can therefore control the liquid application rate and can also the reloading of liquid reservoir(s).", "A liquid removal system, such as a dryer, can comprise one or more relative humidity controllers, temperature controllers and conveyor speed controllers.", "The system is therefore capable of adjusting drying time and conditions to provide printed articles containing the desired level of moisture.", "The liquid removal system may use one or more heat transfer mechanism such as conduction, convection, or radiation.", "In some embodiments, one or more components of the equipment assembly are computer controlled.", "A controller is independently selected at each occurrence from a computerized controller, electronic controller, mechanical controller or a combination thereof.", "In some embodiments, the control system comprises one or more computerized controllers, one or more computers, one or more user interfaces for one or more computers.", "In some embodiments, one or more components of the three-dimensional printing build system are computer controlled.", "In some embodiments, the conveyor system, the height adjustable platforms of the build modules, the at least one powder layering system and the at least one printing system are computer controlled.", "In some embodiments, the equipment assembly is adapted to spread layers of powder and print droplets of liquid in a predetermined pattern according to instructions provided by a computerized controller.", "In some embodiments, the predetermined pattern is based on one or more two-dimensional image files comprising pixels.", "In some embodiments, the two-dimensional image files are structured such that certain pixels indicate dispensing of droplets, and other pixels represent no dispensing of droplets.", "In some embodiments, the two-dimensional image files include different colors of pixels to indicate dispensing of different liquids, or no dispensing of liquid.", "FIGS.", "47-49, depict a flow chart for operation of an exemplary embodiment of the invention.", "The process is initiated, e.g.", "by an operator or electronic component such as a computer.", "An operator activates and checks the status of system and assembly components, which are then synchronized, after which time the system (assembly) is ready for operation.", "Printing fluid and powder are loaded into their respective systems as required of the product to be three-dimensionally printed.", "The level of printing fluid(s) and powder(s) are checked and when the required amount is present, conveyor operation is initiated.", "Moving to FIG.", "48, the powder feed rate and transport speed (conveyor speed) for the build module is applied and a query is made to determine whether or not a build module is supposed to receive powder.", "If so, the platform is lowered and a layer of powder is deposited onto the build module as it passes under the powder fill head.", "If not, the build module does not receive powder.", "A query is then made to determine whether or not the powder layer is supposed to receive a printed image.", "If so, a two-dimensional pattern is printed onto the layer as the build module passes under the print head.", "If not, the build module does not receive printing solution.", "A query is made to determine whether or not all of the build modules mounted on the conveyor have been processed, i.e.", "whether or not the build lap is completed or whether or not the build module is supposed to receive another layer of powder.", "If not, any unprocessed build module is processed.", "If all of the build modules have been processed, i.e.", "the build lap is complete, a query is made to determine whether or not a build cycle is complete.", "If not, one or more additional build laps are conducted.", "If so, the build modules are prepared for unloading of 3DP articles (and/or build modules) as described in FIG.", "49.Completed 3DP articles are unloaded and transferred to a drying system.", "After all 3DP articles have been unloaded, a query is made according to FIG.", "47 to determine whether or not additional build cycles will be conducted.", "If not, the process is terminated.", "If so, the next build cycle process is initiated.", "FIG.", "50 depicts an exemplary subroutine detailing how the platform layer increment is controlled within a build lap and a build cycle.", "In this example, the layer thickness (increment) is provided by a product definition.", "A cumulative thickness is calculated according to the number of powder layers already laid down.", "The platform (punch) is dropped to the calculated thickness and a determination is made to confirm that it is at the correct position within a predefined tolerance.", "A query is then made to determine whether or not the platform of all the build modules in a particular build lap have dropped to the correct position.", "If not, the platforms are adjusted as required.", "If so, a query is made to determine whether or not all layers of a build cycle are complete.", "If not, the process of this figure is repeated for each of the build layers as needed until the build cycle is complete.", "FIG.", "51 describes an exemplary subroutine detailing operation of the printing system.", "A build process is initiated and the necessary amount(s) of printing fluid is loaded into the reservoir(s).", "A set of image files are identified and conveyor operation is begun.", "During operation, the level of printing fluid(s) is monitored so that it can be replenished as needed.", "When a build module passes beneath a printhead, a trigger signal is generated prompting a query to determine whether or not the build module is to receive a printed image.", "If not, the trigger signal is ignored.", "If so, a print image file is received and processed such that the columns of image pixels (pixels that are aligned along the axis of movement of the build module) are assigned to specific jets of the printhead.", "In addition, rows of image pixels are sent to the printhead taking into consideration the linear speed of the conveyor and the intended print density of the image to be printed.", "The printhead then delivers printing fluid droplets, as per the printing instructions, to the powder layer on a build module.", "A query is then made to determine whether or not all build modules have been processed.", "This query can be repeated for the build lap and/or build cycle level.", "Upon completion of a build cycle, the process can be terminated.", "If needed, the printhead can be retracted and cleaned.", "FIG.", "52 depicts a flow chart of an exemplary process for designing a dosage form and determining the layer thickness thereof and image files (two-dimensional printing patterns) there for.", "The process can be conducted with or without a computer.", "A dosage form having a specified three-dimensional structure and comprising a target dose of drug is designed.", "The approximate target powder layer thickness is selected and the height of the dosage form is divided by the target incremental powder layer thickness to provide the number of powder layers required to prepare the dosage form.", "Based upon the layer and its location within the dosage form, each layer is assigned as needed an initial two-dimensional pattern, i.e.", "an image file, which ultimately results in a set of printing instructions employed by the printing system to create a corresponding printed increment layer.", "The image file assigned to each layer can be input, or it can be retrieved from an image library.", "In order to determine whether or not archived images from the image library are required, the system queries whether or not all layers have been assigned an image file as needed.", "If so, the design of the dosage form is complete and the process is terminated.", "If not, the system queries whether or not the image required for a specific layer exists in the image library.", "If so, the image file is retrieved from the library and assigned to the respective powder layer.", "The system then again queries whether or not all layers have been assigned an image file as needed and the loop of logic continues as needed until completion of design of the dosage form.", "If the image file is not present in the image library, a new image file is created, optionally stored in the image library, and assigned to the respective layer, and the loop of logic continues as needed until completion of the dosage form design.", "It should be understood that one or more layers might not require any image file at all, meaning that specific layer would not be printed during preparation of the dosage form.", "The a generalized flow chart for operation of a 3DP system comprising an in-process punch system and in-process drying system is depicted in FIG.", "53.The system determines if an (another) incremental layer should be formed.", "If not, the build operation is terminated and the 3DP article is discharged.", "If so, the system forms a powder layer in a receptacle and determines if binding fluid should be deposited (printed) onto the powder layer.", "If so, it deposits the binding fluid and continues the build operation.", "If not, it continues the build operation and determines if the layer should be dried with an in-process drying system.", "If so, it dries the layer and continues the build operation.", "If not, it continues the build operation and determines if the layer should be punched.", "If so, it punches the layer and continues the build operation.", "If not, it determines whether or not an (another) incremental layer should be formed.", "This operation loop continues until no more incremental layers are to be formed.", "If one or more layers are to be punched in-process, the generalized flow chart of FIG.", "54 can be used for overall operation of the punch system.", "Here, the system determines whether the layer(s) should be translated, compressed, marked or shaped.", "Following completion of one or more of those operations, the build operation is continued.", "A generalized flow chart for operation of the punch system during translation is depicted in FIG.", "55.The punch system receives information containing the target vertical distance that the layer(s) is(are) to be translated within a cavity.", "The lower (and optionally the upper punch) are then moved the target vertical distance to translate the layer(s) in the cavity.", "The upper punch, if it was used, is retracted vertically, and the build operation is continued.", "A generalized flow chart for operation of the punch system during compression is depicted in FIG.", "56.The punch system receives information containing the target compression thickness that one or more layer(s) within a cavity is(are) to be compressed.", "The lower and/or upper punch is(are) then moved to achieve the target thickness.", "The system then determines whether or not the layer(s) must also be vertically translated within the cavity.", "If so, the translation is conducted and operation is continued.", "If not, operation is continued and the upper punch, if it was used, is retracted vertically and the build operation is continued.", "A generalized flow chart for operation of the punch system during marking or shaping is depicted in FIG.", "57.The punch system receives information containing the target vertical drop of the upper punch and/or the target vertical lift of the lower punch.", "The lower and/or upper punch is(are) then moved to achieve the target distance(s).", "The system then determines whether or not the layer(s) must also be vertically translated within the cavity.", "If so, the translation is conducted and operation is continued.", "If not, operation is continued and the upper punch, if it was used, is retracted vertically and the build operation is continued.", "In some embodiments, the bed transfer system or article transfer system is adapted to transfer 3DP beds (3DP articles) to one or more liquid removal systems, one or more harvesting systems and/or one or more packaging systems.", "In some embodiments, the transfer system is integrated with the conveyor system, the liquid removal system or both.", "A liquid removal system is adapted to receive one or more build modules, one or more completed 3DP articles and/or one or more in-process 3DP articles and to remove liquid there from.", "A liquid removal system can be a process area through which one or more of the build modules are conducted.", "For example, the liquid removal system (61) in FIG.", "6 can remove or reduce liquid from the incremented printed layers of an in-process 3DP article.", "Alternatively, the liquid removal system can be another process area not directly associated with the three-dimensional printing build system, such as a temporary retaining or storage area wherein three-dimensionally printed beds are placed and dried under ambient conditions.", "In some embodiments, a liquid removal system is one or more dryers.", "FIG.", "45 depicts an alternate embodiment of a dryer (415) suitable as a liquid removal system.", "The dryer comprises a housing (416), within which are contained plural heating elements (417) and a conveyor system (418).", "The housing comprises an inlet (420) and an outlet (419) through which 3DP articles, and optionally their respective build modules, are conducted by way of the conveyor.", "In some embodiments, the dryer comprises one or more covers (421) for the inlet and/or outlet.", "The dryer optionally further comprises an exhaust system (423) to remove vapor and/or a heated air source (424) that provides heated air to the dryer.", "In some embodiments, the three-dimensionally printed bed comprises loose powder and one or more three-dimensionally printed articles.", "An equipment assembly of the invention can further comprise one or more harvesting systems adapted to separate loose powder from the one or more three-dimensionally printed articles.", "In some embodiments, the harvester comprises loose powder collection means and three-dimensionally printed article collection means.", "In some embodiments, the harvester comprises a vibrating and/or orbiting surface adapted to receive the three-dimensionally printed bed.", "In some embodiments, the harvester comprises one or more deagglomerators.", "In some embodiments, the equipment assembly further comprises one or more dedusters adapted to remove loose powder from articles that have been harvested.", "In some embodiments, a deduster comprises one or more air brushes.", "An deduster system comprises a frame, a receiving platform having an air-dispenser, bed transfer mechanism moveably engaged with the frame and superposing a bed transfer region, aspirator(s), deagglomerator, deduster, printed article collector, and powder collector.", "It can also comprise at least one air brush.", "An article (or build module) transfer mechanism can comprises mounts adapted to translate along tracks.", "The bed transfer mechanism also can comprise a receptacle comprising a cavity adapted to receive and temporarily retain 3DP articles.", "The receptacle can reciprocate in a vertical manner by means of reciprocator engaged with the receptacle and the body of the article transfer mechanism.", "During operation, a conveyor conducts and positions one or more articles beneath the receptacle and in an article transfer region so as to align the article(s) with the cavity.", "The receptacle then lowers onto the transport tray an amount sufficient to retain substantially all of the three-dimensionally printed bed within the cavity.", "An aspirator then aspirates the articles by way of a conduit and a perforated plate in the cavity and above the article, thereby removing a major portion of the loose powder while leaving behind one or more printed articles within the cavity of the receptacle.", "The bed transfer mechanism then slides/translates the printed articles over one or more airbrushes adapted to direct a flow of air at the printed articles in the cavity to assist in releasing additional loose powder from the printed article(s).", "A powder collector is adapted to receive loose powder and other solid material not otherwise collected by the aspirator.", "The article transfer mechanism continues to move until it superposes a deagglomerator.", "The aspirator is then turned off and the printed particles fall onto of the process tray of the deagglomerator, which is adapted to remove and collect agglomerates from the printed article(s) to provide deagglomerated printed articles.", "The article transfer mechanism then returns to its original position in preparation of loading and processing of additional articles.", "The deduster can also comprise a vibrating process tray adapted to remove and collect dust from the deagglomerated printed articles to provide dedusted printed articles.", "The finished printed articles are conducted to a printed article collector.", "The deduster and/or deagglomerator can further comprise solids collector for collecting loose powder and/or agglomerates.", "A deduster system may comprise a housing, receptacle, drawer, enclosure, one or more air jets, e.g.", "air knives, within the enclosure, inlet for the enclosure, and an outlet for the enclosure.", "A perforated build tray having one or more printed articles that have been harvested is placed in the drawer which is subsequently pushed into the enclosure by way of the inlet, thereby forming a substantially enclosed dedusting area.", "One or more air jets direct pressurized air toward the printed article(s), whereby both coarse and fine loose powder that has clung onto the printed article(s) is dislodged there from.", "The loose powder falls into the receptacle and is conducted to the outlet along with the flow of air released by the air jet(s).", "The dedusted printed article(s) is (are) are retrieved by opening of the drawer.", "The recovered loose powder collected in a container.", "Collection of the loose powder can be done manually, mechanically and/or with a vacuum system and/or air-handling system.", "The deduster system and/or the harvester system can be placed within a larger enclosure to minimize spreading of dust in a process area.", "Loose powder, agglomerates or particulates collected during the build cycle, drying, harvesting, deagglomerating and/or dedusting can be disposed or can be blended to form recovered bulk material that can be milled (optionally) and recycled back into a feed supply of virgin unprinted bulk material.", "Such a bulk material recovery system can comprise one or more vacuum systems, one or more pressurized air systems, one or more non-vacuum mechanical systems, one or more manual systems or a combination thereof for transferring bulk material from one location to another.", "In some embodiments, the cavity 3DP assembly excludes a harvester and a powder recycle system.", "Conveyor systems useful for conducting solid articles from one location to another during manufacture include, by way of example, a modular conveyor, non-modular conveyor, continuous conveyor, contiguous conveyor, conveyor belt, cam, pallet conveyor or link conveyor.", "Combinations thereof can be used.", "FIG.", "46 depicts a side elevation view of an exemplary packaging system (425) adapted to package one or more three-dimensionally printed articles (430).", "The system comprises a hopper (426) that provides three-dimensionally printed articles which are placed onto a conveyor (428).", "The articles are conducted through a packaging module (427) that places one or more articles into a package (429).", "Suitable packaging systems can employ bottles, blister packs, tubes, boxes and other such containers.", "The various components and systems of the equipment assembly will comprise parts made of durable materials such as metal, plastic, rubber or a combination thereof.", "In some embodiments, components of the equipment assembly comprise 304 or 316 stainless steel where possible.", "FIG.", "58 depicts a perspective view of a turret disc assembly (440) comprising a removable upper turret disc (or plate; 441) having plural receptacles (cavities) (442) and a lower turret disc (or plate; 443) having plural respective lower punches (height adjustable platforms, 444) that are vertically aligned with respective cavities of the upper disc.", "The upper plate is removably engaged with and can be removed from or installed onto the lower plate (Arrow R).", "The lower plate is optionally removable.", "FIG.", "59 depicts a cross-sectional perspective side elevation view of the turret disc assembly (440).", "The lower disc is engaged with the upper disc and engaged with a drive shaft (445), which rotates (spins) the entire turret assembly during operation.", "Although a drive shaft is depicted, any other means of actuating and spinning the turret assembly can be used.", "The lower disc has punches (incrementally height adjustable platforms) that raise into respective receptacles in the upper disc during operation.", "Since the upper disc and/or lower disc of the turret disc assembly can be removable, the equipment assembly can further comprise a turret disc replacement system.", "FIG.", "60 depicts a 3DP equipment assembly (450) comprising a turret disc replacement system (452), which removes and installs (Arrow S) turret discs (451).", "In some embodiments, the replacement system (452) also rotates (Arrow T) about an axis to remove and reinstall the turret disc.", "The powder can comprise one or more materials suitable for pharmaceutical or non-pharmaceutical use.", "In some embodiments, the powder comprises one or more pharmaceutical excipients, one or more pharmaceutically active agents, or a combination thereof.", "In some embodiments, the three-dimensionally printed article is a pharmaceutical dosage form, medical device, medical implant, or other such article as described.", "Exemplary types of pharmaceutical excipients that can be included in a three-dimensionally printed article include, by way of example and without limitation, chelating agent, preservative, adsorbent, acidifying agent, alkalizing agent, antifoaming agent, buffering agent, colorant, electrolyte, flavorant, polishing agent, salt, stabilizer, sweetening agent, tonicity modifier, antiadherent, binder, diluent, direct compression excipient, disintegrant, glidant, lubricant, opaquant, polishing agent, plasticizer, other pharmaceutical excipient, or a combination thereof.", "Exemplary types of non-pharmaceutical excipients that can be included in a three-dimensionally printed article include, by way of example and without limitation, ash, clay, ceramic, metal, polymer, biological material, plastic, inorganic material, salt, other such materials or a combination thereof.", "In some embodiments, the powder comprises one or more, two or more, three or more, four or more, five or more, six or more, seven or more, eight or more, nine or more, ten or more or plural components, each component being independently selected at each occurrence.", "In some embodiments, the equipment assembly comprises one or more, two or more, three or more, four or more, five or more, six or more, seven or more, eight or more, nine or more, ten or more or plural powder (or solid component) reservoirs.", "Pharmaceutically active agents generally include physiologically or pharmacologically active substances that produce a systemic or localized effect or effects in animals, cells, non-humans and humans.", "When an active agent is present, any such agent can be used.", "Exemplary classes of active agents include, by way of example and without limitation, pesticides, herbicides, insecticides, antioxidants, plant growth instigators, sterilization agents, catalysts, chemical reagents, food products, nutrients, cosmetics, vitamins, sterility inhibitors, fertility instigators, microorganisms, flavoring agents, sweeteners, cleansing agents and other such compounds for pharmaceutical, veterinary, horticultural, household, food, culinary, agricultural, cosmetic, industrial, cleaning, confectionery and flavoring applications.", "Whenever mentioned and unless otherwise specified, the term “active agent” includes all forms of the active agent including neutral, ionic, salt, basic, acidic, natural, synthetic, diastereomeric, isomeric, enantiomerically pure, racemic, hydrate, chelate, derivative, analog, optically active, optically enriched, free base, free acid, regioisomeric, amorphous, anhydrous and/or crystalline forms.", "A three-dimensionally printed dosage form can comprise one, two or more different active agents.", "Particular combinations of active agents can be provided.", "Some combinations of active agents include: 1) a first drug from a first therapeutic class and a different second drug from the same therapeutic class; 2) a first drug from a first therapeutic class and a different second drug from a different therapeutic class; 3) a first drug having a first type of biological activity and a different second drug having about the same biological activity; 4) a first drug having a first type of biological activity and a different second drug having a different second type of biological activity.", "Exemplary combinations of active agents are described herein.", "The active agent can be independently selected at each occurrence from active agents such as an antibiotic agent, antihistamine agent, decongestant, anti-inflammatory agent, antiparasitic agent, antiviral agent, local anesthetic, antifungal agent, amoebicidal agent, trichomonocidal agent, analgesic agent, anti-arthritic agent, anti-asthmatic agent, anticoagulant agent, anticonvulsant agent, antidepressant agent, antidiabetic agent, antineoplastic agent, anti-psychotic agent, neuroleptic agent, antihypertensive agent, hypnotic agent, sedative agent, anxiolytic energizer agent, antiparkinson agent, muscle relaxant agent, antimalarial agent, hormonal agent, contraceptive agent, sympathomimetic agent, hypoglycemic agent, antilipemic agent, ophthalmic agent, electrolytic agent, diagnostic agent, prokinetic agent, gastric acid secretion inhibitor agent, anti-ulcerant agent, anti-flatulent agent, anti-incontinence agent, cardiovascular agent or a combination thereof.", "A description of these and other classes of useful drugs and a listing of species within each class can be found in Martindale, The Extra Pharmacopoeia, 31ST Ed.", "(The Pharmaceutical Press, London 1996), the disclosure of which is incorporated herein by reference in its entirety.", "The above-mentioned lists should not be considered exhaustive and are merely exemplary of the many embodiments considered within the scope of the invention.", "Many other active agents can be included in the powder of the invention.", "The liquid applied to the powder can be a solution or suspension.", "The liquid can comprise an aqueous carrier, nonaqueous carrier, organic carrier or a combination thereof.", "The aqueous carrier can be water or an aqueous buffer.", "The nonaqueous carrier can be an organic solvent, low molecular weight polymer, oil, silicone, other suitable material, alcohol, ethanol, methanol, propanol, isopropanol, poly(ethylene glycol), glycol, other such materials or a combination thereof.", "The terms fluid, printing fluid, binding fluid, and liquid may be used interchangeably to refer to a liquid delivered as part of 3DP.", "In some embodiments, the equipment assembly comprises one or more, two or more, three or more, four or more or plural liquid reservoirs.", "The liquid can be colored or non-colored.", "The liquid can comprise pigment, paint, dye, tint, ink or a combination thereof.", "The liquid can comprise one or more solutes dissolved therein.", "The powder and/or liquid can comprise one or more binders.", "The exemplary embodiments herein should not be considered exhaustive, but merely illustrative of only a few of the many embodiments contemplated by the present invention.", "As used herein, the term “about” is taken to mean a value that is within ±10%, ±5% or ±1% of the indicated value.", "As used herein, “lead accuracy” of a ball screw shall mean the difference between a specified distance and the actual travel distance of the lead screw nut, as is recognized in the relevant art.", "This is expressed as an error over a specified travel distance, and helps determine the accuracy rating of the ball screw.", "“Lead accuracy V300p” shall mean the fluctuation against a travel length of 300 mm.", "The entire disclosures of all documents cited herein are hereby incorporated by reference in their entirety.", "EXAMPLE 1 The following materials and procedure are used to prepare three-dimensionally printed dosage forms that dissolve rapidly in saliva.", "A powder comprising at least one pharmaceutical carrier is loaded into the powder reservoir.", "A fluid comprising a liquid and at least one active ingredient is loaded into the fluid reservoir.", "The equipment assembly is operated, whereby plural stacked incremental layers of printed powder are sequentially formed in build modules by repeatedly passing the build modules through one or more build stations.", "Typically four to fifty incremental printed powder layers are formed and adhere to each other thereby forming a printed bed having one or more articles surrounded by or embedded in loose powder.", "The printed beds are dried in a dryer.", "The printed articles are separated from the loose powder with a harvester.", "The printed articles are then optionally dedusted with a deduster.", "The printed articles are then optionally packaged.", "The above is a detailed description of particular embodiments of the invention.", "It will be appreciated that, although specific embodiments of the invention have been described herein for purposes of illustration, various modifications may be made without departing from the spirit and scope of the invention.", "Accordingly, the invention is not limited except as by the appended claims.", "All of the embodiments disclosed and claimed herein can be made and executed without undue experimentation in light of the present disclosure." ] ]
Patent_15872573
[ [ "METHODS OF PRODUCING PLURIPOTENT STEM CELLS FROM CHONDROCYTES", "Disclosed herein are methods of producing induced pluripotent stem cells from chondrocytes, and further, methods of producing chondrocytes from said induced pluripotent stem cells.", "The invention further provides methods of regenerating cartilaginous tissue." ], [ "1.A method of generating a population of pluripotent or multipotent stem cells from a population of chondrocytes, comprising: a) directing expression of one or more of an Oct3/4 polypeptide, a Sox2 polypeptide, a Klf4 polypeptide, and a c-Myc polypeptide in a population of chondrocytes; and b) culturing the chondrocytes in the presence of pigment endothelium-derived factor (PEDF).", "2.The method of claim 1, further comprising introducing into the population of chondrocytes one or more expression vectors for directing expression of the Oct 3/4, Sox2, Klf4, and c-Myc polypeptides.", "3.The method of claim 2, wherein the one or more expression vectors are retroviral expression vectors, lentiviral expression vectors, adeno-associated viral expression vectors, or adenoviral expression vectors 4.The method of claim 3, wherein the one or more expression vectors are lentiviral expression vectors.", "5.The method of claim 2, wherein the one or more expression vectors comprise a selection marker.", "6.The method of claim 1, wherein the pluripotent or multipotent stem cells express two or more genes selected from the group consisting of Oct4, Rex-1, SSEA4, Tra1-60 and Tra1-81.7.The method of claim 1, wherein the chondrocytes are from an adult human.", "8.A method of generating a population of chondrocytes from a population of pluripotent or multipotent stem cells comprising: i) generating a population of pluripotent or multipotent stem cells according to the method of claim 1; ii) mechanically dissecting the pluripotent or multipotent stem cell colonies in order to produce cell aggregates iii) culturing the cell aggregates in a tissue culture-treated vessel until confluency in order to produce aggregate-derived cells iv) passaging the aggregate-derived cells in culture at least once in order to produce chondroprogenitors; and v) placing the chondroprogenitors into three-dimensional culture; wherein the method does not comprise formation of an embryoid body.", "9.The method of claim 8, wherein the aggregate-derived cells are passaged at least two times in order to produce chondroprogenitors.", "10.The method of claim 9, wherein the aggregate-derived cells are passaged at least three times in order to produce chondroprogenitors.", "11.The method of claim 10, wherein the aggregate-derived cells are passaged at least four times in order to produce chondroprogenitors.", "12.The method of claim 11, wherein the aggregate-derived cells are passaged at least five times in order to produce chondroprogenitors.", "13.The method of claim 12, wherein the aggregate-derived cells are passaged at least six, seven, or eight times in order to produce chondroprogenitors.", "14.The method of claim 8, wherein the chondroprogenitors are placed into three-dimensional aggregate culture in the presence of TGF-β3.15.The method of claim 8, wherein the chondroprogenitors are placed into three-dimensional aggregate culture in the presence of BMP2.16.The method of claim 8, wherein the process of producing cell aggregates does not comprise enzymatic digestion of the pluripotent or multipotent stem cells.", "17.The method of claim 8, wherein culturing the chondroprogenitors in three dimensional culture comprises culturing the cells within a three-dimensional matrix.", "18.The method of claim 17, wherein the three-dimensional matrix comprises collagen, proteoglycan, fibrin, hyaluronic acid, poly-D-lactide, poly-L-lactide, poly-DL-lactide, polyglycolic acid, polylactic acid, hydroxyapatite, calcium phosphate, atelocollagen, fibrin, alginate, agar and/or gelatin.", "19.The method of claim 18, wherein the three-dimensional matrix comprises collagen.", "20.The method of claim 19, wherein the collagen is cross-linked.", "21.The method of claim 19, wherein the collagen is solubilized.", "22.The method of claim 18, wherein the three-dimensional matrix comprises proteoglycan.", "23.The method of claim 8, wherein the tissue culture-treated vessel is plastic.", "24.The method of claim 23, wherein the tissue culture-treated vessel is polystyrene.", "25.A population of induced pluripotent stem (iPS) cells, wherein the stem cells are derived from a population of chondrocytes.", "26.The population of iPS cells of claim 25, wherein the cells were induced from chondrocytes that have been passaged twelve or fewer times after being taken from a live donor.", "27.The population of iPS cells of claim 26, wherein the cells were induced from chondrocytes that have been passaged four or fewer times after being taken from a live donor.", "28.The population of iPS cells of claim 25, wherein the population of iPS cells retain DNA hypo- and hyper-methylation profiles similar to the chondrocytes from which they are derived.", "29.The population of iPS cells of claim 25, that expresses two or more genes selected from the group consisting of Oct4, Rex-1, SSEA4, Tra1-60 and Tra1-81.30.The population of iPS cells of claim 25, wherein the population of iPS cells is generated by a method comprising directing expression of an Oct3/4 polypeptide, a Sox2 polypeptide, and a Klf4 polypeptide in a population of chondrocytes.", "31.The population of iPS cells of claim 25, wherein directing the expression of Oct 3/4, Sox2, and Klf4, comprises introducing into the chondrocytes one or more expression vectors for expression of the Oct 3/4, Sox2, and Klf4 polypeptides.", "32.The population of iPS cells of claim 31, wherein the one or more expression vectors are retroviral expression vectors, lentiviral expression vectors, adeno-associated viral expression vectors, or adenoviral expression vectors.", "33.The population of iPS cells of claim 32, wherein the one or more expression vectors is a lentiviral expression vector.", "34.The population of iPS cells of claim 25, wherein the cells are less than about 20% apoptotic.", "35.The population of iPS cells of claim 34, wherein the cells are less than about 10% apoptotic.", "36.The population of iPS cells of claim 35, wherein the cells are less than about 9% apoptotic, less than about 8% apoptotic, less than about 7% apoptotic, less than about 6% apoptotic, less than about 5% apoptotic, less than about 4% apoptotic, less than about 3% apoptotic, less than about 2% apoptotic, or less than about 1% apoptotic.", "37.A population of cells, wherein the population of cells has been produced by a process comprising: (i) generating a population of pluripotent or multipotent stem cells from a population of chondrocytes by directing expression of polypeptides in the chondrocytes, wherein the polypeptides comprise one or more of an Oct3/4 polypeptide, a Sox2 polypeptide, a Klf4 polypeptide, and a c-Myc polypeptide; (ii) mechanically dissecting the pluripotent or multipotent stem cell colonies; (iii) passaging the cells in culture at least once in order to produce chondroprogenitors; and iv) placing the chondroprogenitors into three-dimensional aggregate culture.", "38.The population of cells of claim 37, wherein the population of cells is homogeneous.", "39.The population of cells of claim 37, wherein the population pluripotent or multipotent stem cells are cultured in the presence of pigment endothelium-derived factor (PEDF) prior to step (ii).", "40.The population of cells of claim 37, wherein the cells have been passaged at least two times in order to produce chondroprogenitors.", "41.The method of claim 40, wherein the aggregate-derived cells are passaged at least three times in order to produce chondroprogenitors.", "42.The method of claim 41, wherein the aggregate-derived cells are passaged at least four times in order to produce chondroprogenitors.", "43.The method of claim 42, wherein the aggregate-derived cells are passaged at least five times in order to produce chondroprogenitors.", "44.The method of claim 43, wherein the aggregate-derived cells are passaged at least six, seven, or eight times in order to produce chondroprogenitors.", "45.A method of regenerating cartilaginous tissue, comprising transplanting a population of cells according to claim 25 or 37 to a bone or cartilage defect, wherein new tissue is produced.", "46.The method of claim 45, wherein the population of cells is transplanted into a bone or cartilage defect in a subject in need thereof.", "47.The method of claim 45, wherein the new tissue integrates with the tissue of the bone or cartilage defect.", "48.The method of claim 45, wherein the new tissue restores the surface of the cartilage or bone.", "49.The method of any of claim 45, wherein the new tissue comprises collagen type II.", "50.The method of any of claim 45, wherein the new tissue comprises superficial, intermediate, and deep zones characteristic of normal articular cartilage.", "51.The method of claim 50, wherein the superficial zone of the new tissue comprises lubricin.", "52.The method of claim 45, wherein the new tissue does not comprise teratomas, neoplastic cells, evidence of deformation, abnormal architectural features, or other inappropriate cell types.", "53.The method of any of claim 45, further comprising administering an agent or device to block vascular invasion at the site of the bone or cartilage defect.", "54.A method of treating a bone or cartilage defect, comprising transplantation of a population of cells according to claim 25 or 37 to the bone or cartilage defect.", "55.The method of claim 54, wherein new tissue is produced.", "56.The method of claim 55, wherein the new tissue integrates with the tissue of the bone or cartilage defect.", "57.The method of claim 55, wherein the new tissue restores the surface of the cartilage or bone.", "58.The method of claim 55, wherein the new tissue comprises collagen type II.", "59.The method of claim 55, wherein the new tissue comprises superficial, intermediate, and deep zones characteristic of normal articular cartilage.", "60.The method of claim 59, wherein the superficial zone of the new tissue comprises lubricin.", "61.A method of treating a cartilage-related disorder in a subject in need thereof, comprising administering a population of cells as claimed in claim 25 or 37 to a site of cartilage injury or defect.", "62.A method according to claim 61 wherein the cartilage-related disorder is articular cartilage trauma, meniscus injury, a chonodrogenesis disorder, arthritis, chondropathy, chondrosarcoma, chondromalacia, polychondritis, relapsing polychondritis, slipped epiphysis, osteochondritis dissecans, chondrodysplasia, costochondritis, osteochondroma, spondylosis, osteochondroses, Tietze syndrome, dermochondrocorneal dystrophy of Francois, epiphyseal dysplasia, carpotarsal osteochondromatosis, achondropasia, chondrocalcinosis, genochondromatosis, chondroma, achondrogenesis, echondromata, hyprochondroplasia, and Keutel syndrome.", "63.The method of claim 62, wherein the cartilage-related disorder is arthritis.", "64.The method of claim 63, wherein the arthritis is osteoarthritis.", "65.The method of claim 64, wherein the osteoarthritis occurs in the knee, finger, wrist, hip, spine, shoulder, elbow, toe, ankle, or neck of a subject.", "66.The use of a population of cells according to claim 25 or 37 in the manufacture of a medicament for treating a cartilage-related disorder.", "67.The use of claim 66, wherein the cartilage-related disorder is articular cartilage trauma, meniscus injury, a chonodrogenesis disorder, arthritis, chondropathy, chondrosarcoma, chondromalacia, polychondritis, relapsing polychondritis, slipped epiphysis, osteochondritis dissecans, chondrodysplasia, costochondritis, osteochondroma, spondylosis, osteochondroses, Tietze syndrome, dermochondrocorneal dystrophy of Francois, epiphyseal dysplasia, carpotarsal osteochondromatosis, achondropasia, chondrocalcinosis, genochondromatosis, chondroma, achondrogenesis, echondromata, hyprochondroplasia, and Keutel syndrome.", "68.The use of claim 66, wherein the cartilage-related disorder is arthritis.", "69.The use of claim 67, wherein the arthritis is osteoarthritis.", "70.The use of claim 68, wherein the osteoarthritis occurs in the knee, finger, wrist, hip, spine, shoulder, elbow, toe, ankle, or neck of a subject.", "71.A cartilage repair implant comprising a biomaterial and a population of cells according to claim 25 or 37.72.A cartilage repair implant according to claim 71, wherein the biomaterial is: collagen, polyglycolic acid (PGA), polylactic acid, alginates (for example, the calcium salt), polyethylene oxide, fibrin adhesive, polylactic acid-polyglycolic acid copolymer, proteoglycans, glycosaminoglycans, human dermis, or a combination thereof.", "73.A method of generating a population of cardiomyocytes from a population of pluripotent or multipotent stem cells comprising: i) generating a population of pluripotent or multipotent stem cells according to the method of claim 1; ii) allowing the population of pluripotent or multipotent stem cells to form embryoid bodies; iii) adding BMP4 to the culture medium; iv) adding BMP4, Activin A, and FGFb for days 1-3 after step iii); v) adding DKK and VEGF for days 3-8 after step iii); and vi) adding DKK, VEGF, and FGFb for days 8-14 after step iii).", "74.The method of claim 73, wherein on day 0, about 5 ng/ml of BMP4 is added to the culture medium.", "75.The method of claim 73, wherein on day 1, about 10 ng/ml of BMP4, about 6 ng/ml of Activin A, and about 5 ng/ml of FGFbeta are added to the culture medium 76.The method of claim 73, wherein on day 3, about 150 ng/ml of DKK and about 5 ng/ml of VEGF are added to the culture medium.", "77.The method of claim 73, wherein on day 8, about 150 ng/ml of DKK, about 10 ng/ml of VEGF and about 5 ng/ml of FGFbeta are added to the culture medium." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Arthritis and cartilage degeneration are leading causes of disability in both the aging population as well as in younger demographics that engage in increasingly intense physical activity starting at earlier ages." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>Disclosed herein, in some embodiments, is a method of generating a population of pluripotent or multipotent stem cells from a population of chondrocytes, comprising: a) directing expression of one or more of an Oct3/4 polypeptide, a Sox2 polypeptide, a Klf4 polypeptide, and a c-Myc polypeptide in a population of chondrocytes; and b) culturing the chondrocytes in the presence of pigment epithelium-derived factor (PEDF).", "In some embodiments, the method further comprises introducing into the population of chondrocytes one or more expression vectors for directing expression of the Oct 3/4, Sox2, Klf4, and c-Myc polypeptides.", "In some embodiments, the one or more expression vectors are retroviral expression vectors, lentiviral expression vectors, adeno-associated viral expression vectors, or adenoviral expression vectors.", "In some embodiments, the one or more expression vectors are lentiviral expression vectors.", "In some embodiments, the one or more expression vectors comprise a selection marker.", "In some embodiments, the pluripotent or multipotent stem cells express two or more genes selected from the group consisting of Oct4, Rex-1, SSEA4, Tra1-60 and Tra1-81.In some embodiments, the chondrocytes are from an adult human.", "Disclosed herein, in some embodiments, is a method of generating a population of chondrocytes from a population of pluripotent or multipotent stem cells comprising: i) generating a population of pluripotent or multipotent stem cells according to the methods disclosed herein; ii) mechanically dissecting the pluripotent or multipotent stem cell colonies in order to produce cell aggregates; iii) culturing the cell aggregates in a tissue culture-treated vessel until confluency in order to produce aggregate-derived cells; iv) passaging the aggregate-derived cells in culture at least once in order to produce chondroprogenitors; and v) placing the chondroprogenitors into three-dimensional culture; wherein the method does not comprise formation of an embryoid body.", "In some embodiments, the aggregate-derived cells are passaged at least two times in order to produce chondroprogenitors.", "In some embodiments, the aggregate-derived cells are passaged at least three times in order to produce chondroprogenitors.", "In some embodiments, the aggregate-derived cells are passaged at least four times in order to produce chondroprogenitors.", "In some embodiments, the aggregate-derived cells are passaged at least five times in order to produce chondroprogenitors.", "In some embodiments, the aggregate-derived cells are passaged at least six, seven, or eight times in order to produce chondroprogenitors.", "In some embodiments, the chondroprogenitors are placed into three-dimensional aggregate culture in the presence of TGF-β3.In some embodiments, the chondroprogenitors are placed into three-dimensional aggregate culture in the presence of BMP2.In some embodiments, the process of producing cell aggregates does not comprise enzymatic digestion of the pluripotent or multipotent stem cells.", "In some embodiments, culturing the chondroprogenitors in three dimensional culture comprises culturing the cells within a three-dimensional matrix.", "In some embodiments, the three-dimensional matrix comprises collagen, proteoglycan, fibrin, hyaluronic acid, poly-D-lactide, poly-L-lactide, poly-DL-lactide, polyglycolic acid, polylactic acid, hydroxyapatite, calcium phosphate, aterocollagen, fibrin, alginate, agar and/or gelatin.", "In some embodiments, the three-dimensional matrix comprises collagen.", "In some embodiments, the collagen is cross-linked.", "In some embodiments, the collagen is solubilized.", "In some embodiments, the three-dimensional matrix comprises proteoglycan.", "In some embodiments, the tissue culture-treated vessel is plastic.", "In some embodiments, the tissue culture-treated vessel is polystyrene.", "Disclosed herein, in some embodiments, is a population of induced pluripotent stem (iPS) cells, wherein the stem cells are derived from a population of chondrocytes.", "In some embodiments, the iPS cells were induced from chondrocytes that have been passaged twelve or fewer times after being taken from a live donor.", "In some embodiments, iPS cells were induced from chondrocytes that have been passaged four or fewer times after being taken from a live donor.", "In some embodiments, the population of iPS cells retain DNA hypo- and hyper-methylation profiles similar to the chondrocytes from which they are derived.", "In some embodiments, the iPS cells express two or more genes selected from the group consisting of Oct4, Rex-1, SSEA4, Tra1-60 and Tra1-81.In some embodiments, the iPS cells are generated by a method comprising directing expression of an Oct3/4 polypeptide, a Sox2 polypeptide, and a Klf4 polypeptide in a population of chondrocytes.", "In some embodiments, directing the expression of Oct 3/4, Sox2, and Klf4, comprises introducing into the chondrocytes one or more expression vectors for expression of the Oct 3/4, Sox2, and Klf4 polypeptides.", "In some embodiments, the one or more expression vectors are retroviral expression vectors, lentiviral expression vectors, adeno-associated viral expression vectors, or adenoviral expression vectors.", "In some embodiments, the one or more expression vectors is a lentiviral expression vector.", "In some embodiments, the cells are less than about 20% apoptotic.", "In some embodiments, the cells are less than about 10% apoptotic.", "In some embodiments, the cells are less than about 9% apoptotic, less than about 8% apoptotic, less than about 7% apoptotic, less than about 6% apoptotic, less than about 5% apoptotic, less than about 4% apoptotic, less than about 3% apoptotic, less than about 2% apoptotic, or less than about 1% apoptotic.", "Disclosed herein, in some embodiments, is a population of cells, wherein the population of cells has been produced by a process comprising: (i) generating a population of pluripotent or multipotent stem cells from a population of chondrocytes by directing expression of polypeptides in the chondrocytes, wherein the polypeptides comprise one or more of an Oct3/4 polypeptide, a Sox2 polypeptide, a Klf4 polypeptide, and a c-Myc polypeptide; (ii) mechanically dissecting the pluripotent or multipotent stem cell colonies in order to produce cell aggregates; (iii) passaging the cells in culture at least once in order to produce chondroprogenitors; and iv) placing the chondroprogenitors into three-dimensional aggregate culture.", "In some embodiments, the population of cells is homogeneous.", "In some embodiments, the population of pluripotent or multipotent stem cells are cultured in the presence of pigment epithelium-derived factor (PEDF) prior to step (ii).", "In some embodiments, the aggregate-derived cells have been passaged at least two times in order to produce chondroprogenitors.", "In some embodiments, the aggregate-derived cells are passaged at least three times in order to produce chondroprogenitors.", "In some embodiments, the aggregate-derived cells are passaged at least four times in order to produce chondroprogenitors.", "In some embodiments, the aggregate-derived cells are passaged at least five times in order to produce chondroprogenitors.", "In some embodiments, the aggregate-derived cells are passaged at least six, seven, or eight times in order to produce chondroprogenitors.", "Disclosed herein, in some embodiments, is a method of regenerating cartilaginous tissue, comprising transplanting a population of cell, as disclosed herein, to a bone or cartilage defect, wherein new tissue is produced.", "In some embodiments, the population of cells is transplanted into a bone or cartilage defect in a subject in need thereof.", "In some embodiments, the new tissue integrates with the tissue of the bone or cartilage defect.", "In some embodiments, the new tissue restores the surface of the cartilage or bone.", "In some embodiments, the new tissue comprises collagen type II.", "In some embodiments, the new tissue comprises superficial, intermediate, and deep zones characteristic of normal articular cartilage.", "In some embodiments, the superficial zone of the new tissue comprises lubricin.", "In some embodiments, the new tissue does not comprise teratomas, neoplastic cells, evidence of deformation, abnormal architectural features, or other inappropriate cell types.", "In some embodiments, the method further comprises administering an agent or device to block vascular invasion at the site of the bone or cartilage defect.", "Disclosed herein, in some embodiments, is a method of treating a bone or cartilage defect, comprising transplantation of a population of cells, as disclosed herein, to the bone or cartilage defect.", "In some embodiments, new tissue is produced.", "In some embodiments, the new tissue integrates with the tissue of the bone or cartilage defect.", "In some embodiments, the new tissue restores the surface of the cartilage or bone.", "In some embodiments, the new tissue comprises collagen type II.", "In some embodiments, the new tissue comprises superficial, intermediate, and deep zones characteristic of normal articular cartilage.", "In some embodiments, the superficial zone of the new tissue comprises lubricin.", "Disclosed herein, in some embodiments, is a method of treating a cartilage-related disorder in a subject in need thereof, comprising administering a population of cells as disclosed herein to a site of cartilage injury or defect.", "In some embodiments, the cartilage-related disorder is articular cartilage trauma, meniscus injury, a chonodrogenesis disorder, arthritis, chondropathy, chondrosarcoma, chondromalacia, polychondritis, relapsing polychondritis, slipped epiphysis, osteochondritis dissecans, chondrodysplasia, costochondritis, osteochondroma, spondylosis, osteochondroses, Tietze syndrome, dermochondrocorneal dystrophy of Francois, epiphyseal dysplasia, carpotarsal osteochondromatosis, achondropasia, chondrocalcinosis, genochondromatosis, chondroma, achondrogenesis, echondromata, hyprochondroplasia, and Keutel syndrome.", "In some embodiments, the cartilage-related disorder is arthritis.", "In some embodiments, the arthritis is osteoarthritis.", "In some embodiments, the osteoarthritis occurs in the knee, finger, wrist, hip, spine, shoulder, elbow, toe, ankle, or neck of a subject.", "Disclosed herein, in some embodiments, is the use of a population of cells disclosed herein in the manufacture of a medicament for treating a cartilage-related disorder.", "In some embodiments, the cartilage-related disorder is articular cartilage trauma, meniscus injury, a chonodrogenesis disorder, arthritis, chondropathy, chondrosarcoma, chondromalacia, polychondritis, relapsing polychondritis, slipped epiphysis, osteochondritis dissecans, chondrodysplasia, costochondritis, osteochondroma, spondylosis, osteochondroses, Tietze syndrome, dermochondrocorneal dystrophy of Francois, epiphyseal dysplasia, carpotarsal osteochondromatosis, achondropasia, chondrocalcinosis, genochondromatosis, chondroma, achondrogenesis, echondromata, hyprochondroplasia, and Keutel syndrome.", "In some embodiments, the cartilage-related disorder is arthritis.", "In some embodiments, the arthritis is osteoarthritis.", "In some embodiments, the osteoarthritis occurs in the knee, finger, wrist, hip, spine, shoulder, elbow, toe, ankle, or neck of a subject.", "Disclosed herein, in some embodiments, is a cartilage repair implant comprising a biomaterial and a population of cells as disclosed herein.", "In some embodiments, the biomaterial is: collagen, polyglycolic acid (PGA), polylactic acid, alginates (for example, the calcium salt), polyethylene oxide, fibrin adhesive, polylactic acid-polyglycolic acid copolymer, proteoglycans, glycosaminoglycans, human dermis, or a combination thereof.", "Disclosed herein, in some embodiments, is a method of generating a population of cardiomyocytes from a population of pluripotent or multipotent stem cells comprising: i) generating a population of pluripotent or multipotent stem cells according to the method of claim 1 ; ii) allowing the population of pluripotent or multipotent stem cells to form embryoid bodies; iii) adding BMP4 to the culture medium; iv) adding BMP4, Activin A, and FGF-β for days 1-3 after step iii); v) adding DKK and VEGF for days 3-8 after step iii); and vi) adding DKK, VEGF, and FGF-β for days 8-14 after step iii).", "In some embodiments, on day 0, about 5 ng/ml of BMP4 is added to the culture medium.", "In some embodiments, on day 1, about 10 ng/ml of BMP4, about 6 ng/ml of Activin A, and about 5 ng/ml of FGF-beta are added to the culture medium.", "In some embodiments, on day 3, about 150 ng/ml of DKK and about 5 ng/ml of VEGF are added to the culture medium.", "In some embodiments, on day 8, about 150 ng/ml of DKK, about 10 ng/ml of VEGF and about 5 ng/ml of FGF-beta are added to the culture medium." ], [ "CROSS-REFERENCE This application is a continuation of U.S. application Ser.", "No.", "14/438,581, filed on Apr.", "24, 2015, which is a U.S. National Stage entry of International Application No.", "PCT/US2013/067350, filed Oct. 29, 2013, which claims the benefit of U.S.", "Application Ser.", "No.", "61/719,901, filed Oct. 29, 2012, all of which are incorporated herein by reference in their entireties.", "BACKGROUND OF THE INVENTION Arthritis and cartilage degeneration are leading causes of disability in both the aging population as well as in younger demographics that engage in increasingly intense physical activity starting at earlier ages.", "SUMMARY OF THE INVENTION Disclosed herein, in some embodiments, is a method of generating a population of pluripotent or multipotent stem cells from a population of chondrocytes, comprising: a) directing expression of one or more of an Oct3/4 polypeptide, a Sox2 polypeptide, a Klf4 polypeptide, and a c-Myc polypeptide in a population of chondrocytes; and b) culturing the chondrocytes in the presence of pigment epithelium-derived factor (PEDF).", "In some embodiments, the method further comprises introducing into the population of chondrocytes one or more expression vectors for directing expression of the Oct 3/4, Sox2, Klf4, and c-Myc polypeptides.", "In some embodiments, the one or more expression vectors are retroviral expression vectors, lentiviral expression vectors, adeno-associated viral expression vectors, or adenoviral expression vectors.", "In some embodiments, the one or more expression vectors are lentiviral expression vectors.", "In some embodiments, the one or more expression vectors comprise a selection marker.", "In some embodiments, the pluripotent or multipotent stem cells express two or more genes selected from the group consisting of Oct4, Rex-1, SSEA4, Tra1-60 and Tra1-81.In some embodiments, the chondrocytes are from an adult human.", "Disclosed herein, in some embodiments, is a method of generating a population of chondrocytes from a population of pluripotent or multipotent stem cells comprising: i) generating a population of pluripotent or multipotent stem cells according to the methods disclosed herein; ii) mechanically dissecting the pluripotent or multipotent stem cell colonies in order to produce cell aggregates; iii) culturing the cell aggregates in a tissue culture-treated vessel until confluency in order to produce aggregate-derived cells; iv) passaging the aggregate-derived cells in culture at least once in order to produce chondroprogenitors; and v) placing the chondroprogenitors into three-dimensional culture; wherein the method does not comprise formation of an embryoid body.", "In some embodiments, the aggregate-derived cells are passaged at least two times in order to produce chondroprogenitors.", "In some embodiments, the aggregate-derived cells are passaged at least three times in order to produce chondroprogenitors.", "In some embodiments, the aggregate-derived cells are passaged at least four times in order to produce chondroprogenitors.", "In some embodiments, the aggregate-derived cells are passaged at least five times in order to produce chondroprogenitors.", "In some embodiments, the aggregate-derived cells are passaged at least six, seven, or eight times in order to produce chondroprogenitors.", "In some embodiments, the chondroprogenitors are placed into three-dimensional aggregate culture in the presence of TGF-β3.In some embodiments, the chondroprogenitors are placed into three-dimensional aggregate culture in the presence of BMP2.In some embodiments, the process of producing cell aggregates does not comprise enzymatic digestion of the pluripotent or multipotent stem cells.", "In some embodiments, culturing the chondroprogenitors in three dimensional culture comprises culturing the cells within a three-dimensional matrix.", "In some embodiments, the three-dimensional matrix comprises collagen, proteoglycan, fibrin, hyaluronic acid, poly-D-lactide, poly-L-lactide, poly-DL-lactide, polyglycolic acid, polylactic acid, hydroxyapatite, calcium phosphate, aterocollagen, fibrin, alginate, agar and/or gelatin.", "In some embodiments, the three-dimensional matrix comprises collagen.", "In some embodiments, the collagen is cross-linked.", "In some embodiments, the collagen is solubilized.", "In some embodiments, the three-dimensional matrix comprises proteoglycan.", "In some embodiments, the tissue culture-treated vessel is plastic.", "In some embodiments, the tissue culture-treated vessel is polystyrene.", "Disclosed herein, in some embodiments, is a population of induced pluripotent stem (iPS) cells, wherein the stem cells are derived from a population of chondrocytes.", "In some embodiments, the iPS cells were induced from chondrocytes that have been passaged twelve or fewer times after being taken from a live donor.", "In some embodiments, iPS cells were induced from chondrocytes that have been passaged four or fewer times after being taken from a live donor.", "In some embodiments, the population of iPS cells retain DNA hypo- and hyper-methylation profiles similar to the chondrocytes from which they are derived.", "In some embodiments, the iPS cells express two or more genes selected from the group consisting of Oct4, Rex-1, SSEA4, Tra1-60 and Tra1-81.In some embodiments, the iPS cells are generated by a method comprising directing expression of an Oct3/4 polypeptide, a Sox2 polypeptide, and a Klf4 polypeptide in a population of chondrocytes.", "In some embodiments, directing the expression of Oct 3/4, Sox2, and Klf4, comprises introducing into the chondrocytes one or more expression vectors for expression of the Oct 3/4, Sox2, and Klf4 polypeptides.", "In some embodiments, the one or more expression vectors are retroviral expression vectors, lentiviral expression vectors, adeno-associated viral expression vectors, or adenoviral expression vectors.", "In some embodiments, the one or more expression vectors is a lentiviral expression vector.", "In some embodiments, the cells are less than about 20% apoptotic.", "In some embodiments, the cells are less than about 10% apoptotic.", "In some embodiments, the cells are less than about 9% apoptotic, less than about 8% apoptotic, less than about 7% apoptotic, less than about 6% apoptotic, less than about 5% apoptotic, less than about 4% apoptotic, less than about 3% apoptotic, less than about 2% apoptotic, or less than about 1% apoptotic.", "Disclosed herein, in some embodiments, is a population of cells, wherein the population of cells has been produced by a process comprising: (i) generating a population of pluripotent or multipotent stem cells from a population of chondrocytes by directing expression of polypeptides in the chondrocytes, wherein the polypeptides comprise one or more of an Oct3/4 polypeptide, a Sox2 polypeptide, a Klf4 polypeptide, and a c-Myc polypeptide; (ii) mechanically dissecting the pluripotent or multipotent stem cell colonies in order to produce cell aggregates; (iii) passaging the cells in culture at least once in order to produce chondroprogenitors; and iv) placing the chondroprogenitors into three-dimensional aggregate culture.", "In some embodiments, the population of cells is homogeneous.", "In some embodiments, the population of pluripotent or multipotent stem cells are cultured in the presence of pigment epithelium-derived factor (PEDF) prior to step (ii).", "In some embodiments, the aggregate-derived cells have been passaged at least two times in order to produce chondroprogenitors.", "In some embodiments, the aggregate-derived cells are passaged at least three times in order to produce chondroprogenitors.", "In some embodiments, the aggregate-derived cells are passaged at least four times in order to produce chondroprogenitors.", "In some embodiments, the aggregate-derived cells are passaged at least five times in order to produce chondroprogenitors.", "In some embodiments, the aggregate-derived cells are passaged at least six, seven, or eight times in order to produce chondroprogenitors.", "Disclosed herein, in some embodiments, is a method of regenerating cartilaginous tissue, comprising transplanting a population of cell, as disclosed herein, to a bone or cartilage defect, wherein new tissue is produced.", "In some embodiments, the population of cells is transplanted into a bone or cartilage defect in a subject in need thereof.", "In some embodiments, the new tissue integrates with the tissue of the bone or cartilage defect.", "In some embodiments, the new tissue restores the surface of the cartilage or bone.", "In some embodiments, the new tissue comprises collagen type II.", "In some embodiments, the new tissue comprises superficial, intermediate, and deep zones characteristic of normal articular cartilage.", "In some embodiments, the superficial zone of the new tissue comprises lubricin.", "In some embodiments, the new tissue does not comprise teratomas, neoplastic cells, evidence of deformation, abnormal architectural features, or other inappropriate cell types.", "In some embodiments, the method further comprises administering an agent or device to block vascular invasion at the site of the bone or cartilage defect.", "Disclosed herein, in some embodiments, is a method of treating a bone or cartilage defect, comprising transplantation of a population of cells, as disclosed herein, to the bone or cartilage defect.", "In some embodiments, new tissue is produced.", "In some embodiments, the new tissue integrates with the tissue of the bone or cartilage defect.", "In some embodiments, the new tissue restores the surface of the cartilage or bone.", "In some embodiments, the new tissue comprises collagen type II.", "In some embodiments, the new tissue comprises superficial, intermediate, and deep zones characteristic of normal articular cartilage.", "In some embodiments, the superficial zone of the new tissue comprises lubricin.", "Disclosed herein, in some embodiments, is a method of treating a cartilage-related disorder in a subject in need thereof, comprising administering a population of cells as disclosed herein to a site of cartilage injury or defect.", "In some embodiments, the cartilage-related disorder is articular cartilage trauma, meniscus injury, a chonodrogenesis disorder, arthritis, chondropathy, chondrosarcoma, chondromalacia, polychondritis, relapsing polychondritis, slipped epiphysis, osteochondritis dissecans, chondrodysplasia, costochondritis, osteochondroma, spondylosis, osteochondroses, Tietze syndrome, dermochondrocorneal dystrophy of Francois, epiphyseal dysplasia, carpotarsal osteochondromatosis, achondropasia, chondrocalcinosis, genochondromatosis, chondroma, achondrogenesis, echondromata, hyprochondroplasia, and Keutel syndrome.", "In some embodiments, the cartilage-related disorder is arthritis.", "In some embodiments, the arthritis is osteoarthritis.", "In some embodiments, the osteoarthritis occurs in the knee, finger, wrist, hip, spine, shoulder, elbow, toe, ankle, or neck of a subject.", "Disclosed herein, in some embodiments, is the use of a population of cells disclosed herein in the manufacture of a medicament for treating a cartilage-related disorder.", "In some embodiments, the cartilage-related disorder is articular cartilage trauma, meniscus injury, a chonodrogenesis disorder, arthritis, chondropathy, chondrosarcoma, chondromalacia, polychondritis, relapsing polychondritis, slipped epiphysis, osteochondritis dissecans, chondrodysplasia, costochondritis, osteochondroma, spondylosis, osteochondroses, Tietze syndrome, dermochondrocorneal dystrophy of Francois, epiphyseal dysplasia, carpotarsal osteochondromatosis, achondropasia, chondrocalcinosis, genochondromatosis, chondroma, achondrogenesis, echondromata, hyprochondroplasia, and Keutel syndrome.", "In some embodiments, the cartilage-related disorder is arthritis.", "In some embodiments, the arthritis is osteoarthritis.", "In some embodiments, the osteoarthritis occurs in the knee, finger, wrist, hip, spine, shoulder, elbow, toe, ankle, or neck of a subject.", "Disclosed herein, in some embodiments, is a cartilage repair implant comprising a biomaterial and a population of cells as disclosed herein.", "In some embodiments, the biomaterial is: collagen, polyglycolic acid (PGA), polylactic acid, alginates (for example, the calcium salt), polyethylene oxide, fibrin adhesive, polylactic acid-polyglycolic acid copolymer, proteoglycans, glycosaminoglycans, human dermis, or a combination thereof.", "Disclosed herein, in some embodiments, is a method of generating a population of cardiomyocytes from a population of pluripotent or multipotent stem cells comprising: i) generating a population of pluripotent or multipotent stem cells according to the method of claim 1; ii) allowing the population of pluripotent or multipotent stem cells to form embryoid bodies; iii) adding BMP4 to the culture medium; iv) adding BMP4, Activin A, and FGF-β for days 1-3 after step iii); v) adding DKK and VEGF for days 3-8 after step iii); and vi) adding DKK, VEGF, and FGF-β for days 8-14 after step iii).", "In some embodiments, on day 0, about 5 ng/ml of BMP4 is added to the culture medium.", "In some embodiments, on day 1, about 10 ng/ml of BMP4, about 6 ng/ml of Activin A, and about 5 ng/ml of FGF-beta are added to the culture medium.", "In some embodiments, on day 3, about 150 ng/ml of DKK and about 5 ng/ml of VEGF are added to the culture medium.", "In some embodiments, on day 8, about 150 ng/ml of DKK, about 10 ng/ml of VEGF and about 5 ng/ml of FGF-beta are added to the culture medium.", "BRIEF DESCRIPTION OF THE DRAWINGS The novel features of the invention are set forth with particularity in the appended claims.", "A better understanding of the features and advantages of the present invention will be obtained by reference to the following detailed description that sets forth illustrative embodiments, in which the principles of the invention are utilized, and the accompanying drawings of which: FIG.", "1 exemplifies proliferation rate of human chondrocytes transfected with Lentismart OKSM in the presence of FGF-β (10 ng/ml) or PEDF (100 ng/ml).", "Control indicates the culture medium, (DMEM/F12 with 10% FBS).", "FIG.", "2 exemplifies iPSCs derived from human chondrocytes as expressing pluripotent stem cell markers.", "After transforming human articular chondrocytes with lentiviral expression vectors for Oct4, Sox2, Klf4, and c-Myc, two cell lines (ChniPSC2 and ChniPSC3) morphologically resembling human embryonic stem cells were expanded.", "Human embryonic stem cell lines H7 and H9 were used as positive controls Immunocytochemistry results indicated that both iPSC lines, ChniPSC2 and ChniPSC3, were positive for Oct4, Rex-1, SSEA4, Tra1-60, and Tra1-81 expression.", "The expression level of the markers and the morphology of iPSC are indistinguishable from the H7 and H9 human embryonic stem cell lines.", "FIG.", "3 exemplifies the chondrogenic potential of iPSC cell lines (ChIPSC and ChiPSC 2 derived from chondrocytes; HDFiPSC derived from human dermal fibroblasts) in pellet culture as indicated by type II collagen mRNA expression, where H9 exemplifies human embryonic stem cell line H9 becoming chondrogenic in pellet culture.", "The iPS cell lines derived from chondrocytes expressed far greater type II collagen mRNA (y axis is a log scale).", "FIG.", "4 exemplifies chondroprogenitors differentiated from both chondrocyte-derived iPSC cells lines being able to fill cartilage defects with regenerated tissue at 8 weeks after in vivo implantation in rabbit knees.", "The defects in the joint tissue became filled with tissue which stained positive for glycosaminoglycans (by Safranin O stain).", "DETAILED DESCRIPTION OF THE INVENTION Cartilage is formed in the ear, nose, trachea, joints and intervertebral discs.", "When cartilage is impaired by trauma (such as damage of articular cartilage), or by aging-related diseases (such as arthrosis deformans), inflammatory diseases (such as rheumatoid arthritis), large-sized cartilage defect after surgery of tumors, and congenital anomaly, daily life is severely impaired such that normal everyday activities such as walking become painful and debilitating.", "Disclosed herein, in certain embodiments, are methods of culturing human chondrocytes without obtaining mesenchymal stem cells from multiple bone marrow donors.", "This method may be used to provide a supply of chondrocytes for use in research, pharmaceutical development, and the therapeutic management cartilage-defect related diseases and disorders.", "Further disclosed herein, in certain embodiments, are cartilage therapy materials using the produced chondrocytes.", "Disclosed herein, in some embodiments, is a method of generating a population of pluripotent or multipotent cells from a population of chondrocytes, comprising: a) directing expression of one or more of Oct3/4, Sox2, Klf4, and c-Myc in a population of chondrocytes; and b) culturing the chondrocytes in the presence of pigment epithelium-derived factor (PEDF), to produce a population of pluripotent or multipotent cells.", "In some embodiments, the method further comprises introducing into the population of chondrocytes one or more expression vectors for directing expression of the Oct 3/4, Sox2, Klf4, and c-Myc.", "In some embodiments, the one or more expression vectors are retroviral expression vectors, lentiviral expression vectors, adeno-associated viral expression vectors, or adenoviral expression vectors.", "In some embodiments, the one or more expression vectors are lentiviral expression vectors.", "In some embodiments, the one or more expression vectors comprise a selection marker.", "In some embodiments, the pluripotent or multipotent stem cells express two or more genes selected from the group consisting of Oct4, Rex-1, SSEA4, Tra1-60 and Tra1-81.In some embodiments, the chondrocytes are from an adult human.", "Disclosed herein, in some embodiments, is a method of generating a population of chondrocytes from a population of pluripotent or multipotent stem cells comprising: i) generating a population of pluripotent or multipotent stem cells according to the methods disclosed herein; ii) mechanically dissecting the pluripotent or multipotent stem cell colonies, to produce cell aggregates; iii) culturing the cell aggregates in a tissue culture-treated vessel until confluency to produce aggregate-derived cells; iv) passaging the aggregate-derived cells in culture at least once in order to produce chondroprogenitors; and v) culturing the chondroprogenitors in a three-dimensional culture; wherein the method does not comprise formation of an embryoid body.", "In some embodiments, the aggregate-derived cells are passaged at least two times.", "In some embodiments, the aggregate-derived cells are passaged at least three times.", "In some embodiments, the aggregate-derived cells are passaged.", "In some embodiments, the aggregate-derived cells are passaged at least five times.", "In some embodiments, the aggregate-derived cells are passaged at least six, seven, or eight times.", "In some embodiments, the three-dimensional culture comprises TGF-β3.In some embodiments, the three-dimensional culture comprises BMP2.In some embodiments, the process of producing cell aggregates does not comprise enzymatic digestion of the pluripotent or multipotent stem cells.", "In some embodiments, the three dimensional culture comprises a three-dimensional matrix.", "In some embodiments, the three-dimensional matrix comprises collagen, proteoglycan, fibrin, hyaluronic acid, poly-D-lactide, poly-L-lactide, poly-DL-lactide, polyglycolic acid, polylactic acid, hydroxyapatite, calcium phosphate, aterocollagen, fibrin, alginate, agar and/or gelatin.", "In some embodiments, the three-dimensional matrix comprises collagen.", "In some embodiments, the collagen is cross-linked.", "In some embodiments, the collagen is solubilized.", "In some embodiments, the three-dimensional matrix comprises proteoglycan.", "In some embodiments, the tissue culture-treated vessel is plastic.", "In some embodiments, the tissue culture-treated vessel is polystyrene.", "Disclosed herein, in some embodiments, is a population of induced pluripotent stem (iPS) cells, wherein the iPS cells are derived from a population of chondrocytes.", "In some embodiments, the population of chondrocytes are passaged twelve or fewer times after being taken from a live donor.", "In some embodiments, the chondrocytes are passaged four or fewer times after being taken from a live donor.", "In some embodiments, the population of iPS cells have DNA hypo- and hyper-methylation profiles similar to the chondrocytes from which they are derived.", "In some embodiments, the iPS cells express two or more genes selected from the group consisting of Oct4, Rex-1, SSEA4, Tra1-60 and Tra1-81.In some embodiments, the iPS cells are generated by a method comprising directing expression of one or more of Oct3/4, Sox2, and Klf4 in a population of chondrocytes.", "In some embodiments, directing the expression of Oct 3/4, Sox2, and Klf4, comprises introducing into the chondrocytes one or more expression vectors for expression of the Oct 3/4, Sox2, and Klf4 polypeptides.", "In some embodiments, the one or more expression vectors are retroviral expression vectors, lentiviral expression vectors, adeno-associated viral expression vectors, or adenoviral expression vectors.", "In some embodiments, the one or more expression vectors is a lentiviral expression vector.", "In some embodiments, the population of iPS cells is less than about 20% apoptotic.", "In some embodiments, the cells are less than about 10% apoptotic.", "In some embodiments, the cells are less than about 9% apoptotic, less than about 8% apoptotic, less than about 7% apoptotic, less than about 6% apoptotic, less than about 5% apoptotic, less than about 4% apoptotic, less than about 3% apoptotic, less than about 2% apoptotic, or less than about 1% apoptotic.", "Disclosed herein, in some embodiments, is a population of cells produced by a process comprising: (i) generating a population of pluripotent or multipotent cells from a population of chondrocytes by directing expression of Oct3/4, Sox2, Klf4, and c-Myc to produce a population of pluripotent or multipotent cells; (ii) mechanically dissecting the pluripotent or multipotent cell colonies to produce cell aggregates; (iii) passaging the cell aggregates in culture at least once to produce chondroprogenitors; and iv) culturing chondroprogenitors in three-dimensional culture.", "In some embodiments, the population of cells is homogeneous.", "In some embodiments, the population of pluripotent or multipotent cells are cultured in the presence of pigment epithelium-derived factor (PEDF) prior to step (ii).", "In some embodiments, the aggregate-derived cells have been passaged at least two times.", "In some embodiments, the aggregate-derived cells are passaged at least three times.", "In some embodiments, the aggregate-derived cells are passaged at least four times.", "In some embodiments, the aggregate-derived cells are passaged at least five times.", "In some embodiments, the aggregate-derived cells are passaged at least six, seven, or eight times.", "Disclosed herein, in some embodiments, is a method of regenerating cartilaginous tissue, comprising transplanting a population of cells, as produced by the methods disclosed herein, to a bone or cartilage defect, wherein new cartilaginous tissue is produced.", "In some embodiments, the population of cells is transplanted into a bone or cartilage defect in a subject in need thereof.", "In some embodiments, the new cartilaginous tissue integrates with the tissue of the bone or cartilage defect.", "In some embodiments, the new cartilaginous tissue restores the surface of the cartilage or bone.", "In some embodiments, the new cartilaginous tissue comprises collagen type II.", "In some embodiments, the new cartilaginous tissue comprises superficial, intermediate, and deep zones characteristic of normal articular cartilage.", "In some embodiments, the superficial zone of the new cartilaginous tissue comprises lubricin.", "In some embodiments, the new cartilaginous tissue does not comprise teratomas, neoplastic cells, evidence of deformation, abnormal architectural features, or other inappropriate cell types.", "In some embodiments, the method further comprises administering an agent or device to block vascular invasion at the site of the bone or cartilage defect.", "Disclosed herein, in some embodiments, is a method of treating a bone or cartilage defect, comprising transplantation of a population of cells, produced by the methods disclosed herein, to the bone or cartilage defect.", "In some embodiments, new cartilaginous tissue is produced.", "In some embodiments, the new cartilaginous tissue integrates with the tissue of the bone or cartilage defect.", "In some embodiments, the new cartilaginous tissue restores the surface of the cartilage or bone.", "In some embodiments, the new cartilaginous tissue comprises collagen type II.", "In some embodiments, the new cartilaginous tissue comprises superficial, intermediate, and deep zones characteristic of normal articular cartilage.", "In some embodiments, the superficial zone of the new cartilaginous tissue comprises lubricin.", "Disclosed herein, in some embodiments, is a method of treating a cartilage-related disorder in a subject in need thereof, comprising administering a population of cells, as produced by the methods disclosed herein to a site of cartilage injury or defect.", "In some embodiments, the cartilage-related disorder is articular cartilage trauma, meniscus injury, a chonodrogenesis disorder, arthritis, chondropathy, chondrosarcoma, chondromalacia, polychondritis, relapsing polychondritis, slipped epiphysis, osteochondritis dissecans, chondrodysplasia, costochondritis, osteochondroma, spondylosis, osteochondroses, Tietze syndrome, dermochondrocorneal dystrophy of Francois, epiphyseal dysplasia, carpotarsal osteochondromatosis, achondropasia, chondrocalcinosis, genochondromatosis, chondroma, achondrogenesis, echondromata, hyprochondroplasia, and Keutel syndrome.", "In some embodiments, the cartilage-related disorder is arthritis.", "In some embodiments, the arthritis is osteoarthritis.", "In some embodiments, the osteoarthritis occurs in the knee, finger, wrist, hip, spine, shoulder, elbow, toe, ankle, or neck of a subject.", "Disclosed herein, in some embodiments, is the use of a population of cells disclosed herein for treating a cartilage-related disorder.", "In some embodiments, the cartilage-related disorder is articular cartilage trauma, meniscus injury, a chonodrogenesis disorder, arthritis, chondropathy, chondrosarcoma, chondromalacia, polychondritis, relapsing polychondritis, slipped epiphysis, osteochondritis dissecans, chondrodysplasia, costochondritis, osteochondroma, spondylosis, osteochondroses, Tietze syndrome, dermochondrocorneal dystrophy of Francois, epiphyseal dysplasia, carpotarsal osteochondromatosis, achondropasia, chondrocalcinosis, genochondromatosis, chondroma, achondrogenesis, echondromata, hyprochondroplasia, and Keutel syndrome.", "In some embodiments, the cartilage-related disorder is arthritis.", "In some embodiments, the arthritis is osteoarthritis.", "In some embodiments, the osteoarthritis occurs in the knee, finger, wrist, hip, spine, shoulder, elbow, toe, ankle, or neck of a subject.", "Disclosed herein, in some embodiments, is a cartilage repair implant comprising a biomaterial substrate and a population of cells as disclosed herein.", "In some embodiments, the biomaterial substrate is: collagen, polyglycolic acid (PGA), polylactic acid, alginates (for example, the calcium salt), polyethylene oxide, fibrin adhesive, polylactic acid-polyglycolic acid copolymer, proteoglycans, glycosaminoglycans, human dermis, or a combination thereof.", "Disclosed herein, in some embodiments, is a method of generating a population of cardiomyocytes from a population of pluripotent or multipotent cells comprising: i) generating a population of pluripotent or multipotent cells according to the methods disclosed herein; ii) allowing the population of pluripotent or multipotent cells to form embryoid bodies in a culture medium; iii) adding BMP4 to the culture medium (day 0); iv) adding BMP4, Activin A, and FGF-β for days 1-3 after step iii); v) adding DKK and VEGF for days 3-8 after step iii); and vi) adding DKK, VEGF, and FGF-β for days 8-14 after step iii).", "In some embodiments, on day 0, about 5 ng/ml of BMP4 is added to the culture medium.", "In some embodiments, on day 1, about 10 ng/ml of BMP4, about 6 ng/ml of Activin A, and about 5 ng/ml of FGF-beta are added to the culture medium.", "In some embodiments, on day 3, about 150 ng/ml of DKK and about 5 ng/ml of VEGF are added to the culture medium.", "In some embodiments, on day 8, about 150 ng/ml of DKK, about 10 ng/ml of VEGF and about 5 ng/ml of FGF-beta are added to the culture medium.", "Generating Induced Pluripotent Stem Cells from Chondrocytes Disclosed herein are methods and compositions for generating pluripotent or multipotent cells from a population of chondrocytes.", "Disclosed herein, in some embodiments, are methods of generating a population of pluripotent or multipotent cells from a population of chondrocytes, comprising: a) directing expression of Oct3/4 polypeptide, a Sox2 polypeptide, a Klf4 polypeptide, and a c-Myc polypeptide in a population of chondrocytes; and b) culturing in the presence of pigment epithelium-derived factor (PEDF).", "In some embodiments, the method further comprises transforming the population of chondrocytes with one or more expression vectors for expression of the Oct 3/4, Sox2, Klf4, and c-Myc polypeptides.", "In some embodiments, the one or more expression vectors are each independently selected form: retroviral expression vectors, lentiviral expression vectors, adeno-associated viral expression vectors, and adenoviral expression vectors.", "In some embodiments, at least one of the one or more expression vectors is a lentiviral expression vector.", "In some embodiments, at least one of the one or more expression vectors comprises a selection marker.", "In some embodiments, the pluripotent or multipotent cells express two or more genes selected from the group consisting of Oct4, Rex-1, SSEA4, Tra1-60 and Tra1-81.In some embodiments, the chondrocytes are from an adult human.", "In some embodiments, the chondrocytes are from a human children or human adolescents.", "In some embodiments, disclosed herein is a population of induced pluripotent stem cells, wherein the iPS cells are derived from a population of chondrocytes.", "In some embodiments, the iPS cells were induced from chondrocytes passaged twelve or fewer times after being taken from a live donor.", "In some embodiments, the iPS cells were induced from chondrocytes passaged 10 or fewer times after being taken from a live donor.", "In some embodiments, the iPS cells were induced from chondrocytes passaged 8 or fewer times after being taken from a live donor.", "In some embodiments, the iPS cells were induced from chondrocytes passaged 6 or fewer times after being taken from a live donor.", "In some embodiments, the iPS cells were induced from chondrocytes passaged four or fewer times after being taken from a live donor.", "In some embodiments, the iPS cells were induced from chondrocytes passaged twice or fewer times after being taken from a live donor.", "In some embodiments, the iPS cells were induced from chondrocytes passaged once after being taken from a live donor.", "In some embodiments, the iPS cells were induced from chondrocytes that have not been passaged since being taken from a live donor.", "In some embodiments, the population of stem cells retain DNA hypo- and hyper-methylation profiles similar to the chondrocytes from which they are derived.", "In some embodiments, the cells express two or more genes selected from the group consisting of Oct4, Rex-1, SSEA4, Tra1-60 and Tra1-81.In some embodiments, the population of induced pluripotent stem cells is generated by a method comprising directing expression of an Oct3/4 polypeptide, a Sox2 polypeptide, and a Klf4 polypeptide.", "In some embodiments, directing the expression of Oct 3/4, Sox2, and Klf4, comprises transforming into the chondrocytes one or more expression vectors for directing expression of Oct 3/4, Sox2, and Klf4 polypeptides.", "In some embodiments, the one or more expression vectors are each independently selected from: retroviral expression vectors, lentiviral expression vectors, adeno-associated viral expression vectors, and adenoviral expression vectors.", "In some embodiments, at least one of the one or more expression vectors is a lentiviral expression vector.", "In some embodiments, the chondrocytes are from a human subject.", "In some embodiments, the chondrocytes are from an adult human.", "In some embodiments, the chondrocytes are from a human child or a human adolescent.", "In some embodiments, the chondrocytes are derived from non-human subjects, e.g., non-human mammals.", "Examples of non-human mammals include, but are not limited to, non-human primates (e.g., apes, monkeys, gorillas), rodents (e.g., mice, rats), cows, pigs, sheep, horses, dogs, cats, or rabbits.", "In some embodiments, the methods for generating a population of pluripotent or multipotent stem cells from a population of chondrocytes further comprises directing expression of a set of polypeptide induction factors.", "Methods for directing expression of a polypeptide induction factor includes, but is not limited to, introducing expression vectors encoding polypeptide induction factors, introducing exogenous purified induction factor polypeptides into cells, or contacting cells with a non-naturally occurring reagent that induces expression of an endogenous gene encoding a polypeptide induction factor.", "In some embodiments, the cells to be induced are cultured for a period of time prior to the induction procedure.", "Alternatively, in some embodiments, the cells to be induced are used directly in the induction and selection process without a prior culture period.", "In some embodiments, different cell culture media is used at different points prior to, during, and after the induction and selection process.", "In some embodiments, the selection process includes one or more rounds of positive selection, negative selection, or both.", "In some embodiments, the set of induction factor polypeptides comprises one or more of: an Oct3/4 polypeptide, a Sox2 polypeptide, a Klf4 polypeptide, and a c-Myc polypeptide.", "In some embodiments, the set of induction factor polypeptides does not include a c-Myc polypeptide.", "In some embodiments, the amino acid sequence of an induction factor polypeptide is a non-naturally occurring amino acid sequence variant of an induction factor polypeptide that is, nevertheless, functionally or structurally homologous to an induction factor polypeptide amino acid sequence, as described herein.", "In some embodiments, the set of induction factor polypeptides includes: an Oct3/4 polypeptide, a Sox2 polypeptide, and a Klf4 polypeptide.", "In some embodiments a single induction factor polypeptide is used for induction, and is selected from Oct 3/4 or Sox2.In some embodiments, the set of induction factor polypeptides includes two induction factor polypeptides, e.g., Oct3/4 and Sox2.In some embodiments, the set of induction factor polypeptides includes three induction factor polypeptides selected from an Oct3/4 polypeptide, a Sox2 polypeptide, a Klf4 polypeptide, and a c-Myc polypeptide.", "In some embodiments, the methods disclosed herein further comprise directed expression of an additional induction factor polypeptide.", "In some embodiments, additional induction factor polypeptides include, but are not limited to Nanog, TERT, LIN28, CYP26A1, GDF3, FoxD3, Zfp42, Dnmt3b, Ecat1, and Tcl1 polypeptides.", "In some embodiments, the methods disclosed herein further comprising directing expression of the induction factor polypeptides for a period of at least about 7 days to at least about 40 days, e.g., 8 days, 9 days, 10 days, 11 days, 12 days, 13 days, 14 days, 15 days, 16 days, 17 days, 18 days, 19 days, 20 days, 21 days, 25 days, 30 days, 33 days, 37 days, 40 days, or 45 days.", "In some embodiments, the efficiency of inducing pluripotency in cells from a population of chondrocytes is from at least about 0.001% to at least about 0.1% of the total number of parental chondrocyte cells cultured initially, e.g., 0.002%, 0.0034%, 0.004%, 0.005%, 0.0065%, 0.007%, 0.008%, 0.01%, 0.04%, 0.06%, 0.08%, or 0.09%.", "At times, depending on the age of the donor, the origin of the tissue, or the culture conditions, higher efficiencies may be achieved.", "In some embodiments, directed expression of the induction factor polypeptides comprises transforming one or more mammalian expression vectors encoding the induction factor polypeptides into a population of chondrocytes.", "In some embodiments, genes encoding the induction factor polypeptides are introduced into the cells as exogenous genes.", "In some embodiments, the exogenous genes are integrated into the genome of a host cell and its progeny.", "In some embodiments, the exogenous genes persist in an episomal state in the host cell and its progeny.", "In some embodiments, the induction factor polypeptides are genetically fused in frame with a transport protein amino acid sequence, e.g., a VP22 polypeptide.", "In some embodiments, the use of vectors encoding induction factor-VP22 fusion polypeptides increases the functional efficiency of transfected expression vectors in the induction methods described herein.", "Examples of suitable mammalian expression vectors include, but are not limited to: recombinant viruses, nucleic acid vectors, such as plasmids, bacterial artificial chromosomes, yeast artificial chromosomes, human artificial chromosomes, transposon vectors, cDNA, cRNA, and PCR product expression cassettes.", "Examples of suitable promoters for driving expression of IFs include, but are not limited to, retroviral LTR elements; constitutive promoters such as, CMV, CAG, HSV1-TK, SV40, EF-1α, β-actin; PGK, and inducible promoters, such as those containing Tet-operator elements.", "In some embodiments, one or more of the mammalian expression vectors further comprises a nucleic acid sequence encoding a marker gene that facilitates identification or selection of cells that have been transfected or infected.", "Examples of marker genes include, but are not limited to, genes encoding fluorescent proteins, e.g., EGFP, DS-Red, monomeric Orange, YFP, and CFP; and antibiotic resistance genes, e.g., the neoR gene, and the blasticidin resistance gene.", "In some embodiments, the methods further comprise selecting and/or screening cells for a number of properties that characterize pluripotent stem cells (e.g., morphological characteristics, gene expression during directed expression of induction factors.", "In some embodiments, induced cells that meet these screening criteria are subcloned and expanded.", "In some embodiments, after directing expression of the induction factor polypeptides, one or more growth factors, such as pigment epithelium-derived factor (PEDF); fibroblast growth factor (FGF)-2; basic FGF (bFGF); platelet-derived growth factor (PDGF), epidermal growth factor (EGF); insulin-like growth factor (IGF); IGF II; or insulin, is included in the culture medium.", "Other growth factors that can be used to supplement cell culture media include, but are not limited to one or more: Transforming Growth Factor β-1 (TGF β-1), Activin A, Noggin, Brain-derived Neurotrophic Factor (BDNF), Nerve Growth Factor (NGF), Neurotrophin (NT)-1, NT-2, or NT-3.In some embodiments, PEDF is included in the culture medium.", "In some embodiments, PEDF prevents overgrowth of the induced cell population.", "In some embodiments the concentration of growth factor(s) is from about 4 ng/ml to about 50 ng/ml, e.g., about 2 ng/ml, 3 ng/ml, 4 ng/ml, 5 ng/ml, 6 ng/ml, 7 ng/ml, 8 ng/ml, 10 ng/ml, 12 ng/ml, 14 ng/ml, 15 ng/ml, 17 ng/ml, 20 ng/ml, 25 ng/ml, 30 ng/ml, 35 ng/ml, 40 ng/ml, 45 ng/ml, or 50 ng/ml.", "The concentration of growth factors may also be from about 4 ng/ml to about 10 ng/ml; from about 4 ng/ml to about 20 ng/ml; from about 10 ng/ml to about 30 ng/ml; from about 5 ng/ml to about 40 ng/ml; or from about 10 ng/ml to about 50 ng/ml.", "In other cases, higher concentrations of growth factors may be used, e.g., from about 50 ng/ml to about 200 ng/ml; or from about 75 ng/ml to about 150 ng/ml.", "In some embodiments, from about 50 ng/ml to about 200 ng/ml of PEDF is added to the post-induction culture medium.", "In some embodiments, about 100 ng/ml of PEDF is added to the post-induction culture medium.", "In some embodiments, morphological characteristics for identifying candidate multipotent or pluripotent cell colonies are selected from: a rounder, smaller cell size relative to surrounding cells and a high nucleus-to-cytoplasm ratio.", "In some embodiments, the size of the candidate induced cell is from about 5 μm to about 10 μm; from about 5 μm to about 15 μm; from about 5 μm to about 30 μm; from about 10 μm to about 30 μm; or from about 20 μm to about 30 μm.", "In some embodiments, a high nucleus-to-cytoplasm ratio is from about 1.5:1 to about 10:1, e.g., about 1.5:1; about 2:1; about 3:1; about 4:1; about 5:1; about 7:1; about 8:1; about 9.5:1; or about 10:1.In some embodiments the pluripotent or multipotent cell clones derived from a human or primate display a flattened morphology relative to mouse embryonic stem cells.", "In some embodiments, another morphological characteristic for identifying induced cell clones is the formation of small monolayer colonies within the space between parental cells (e.g., between chondrocytes).", "In some embodiments, the cells in which induction factor expression is directed are plated and cultured directly on tissue culture-grade plastic.", "Alternatively, cells are plated and cultured on a coated substrate, e.g., a substrate coated with fibronectin, gelatin, Matrigel™ (BD Bioscience), collagen, or laminin.", "In some cases, untreated petri-dishes may be used.", "Suitable cell culture vessels include, e.g., 35 mm, 60 mm, 100 mm, and 150 mm cell culture dishes, 6-well cell culture plates, and other size-equivalent cell culture vessels.", "In some embodiments, the cells are cultured with feeder cells.", "For example, the cells may be cultured on a layer, or carpet, of MEFs (e.g., irradiated or mitomycin-treated MEFs).", "In some embodiments, pluripotent or multipotent cells derived from chondrocytes retain epigenetic memory.", "In some embodiments, a population of pluripotent or multipotent cells derived from chondrocytes, according to the methods disclosed herein, retain DNA hypo- and hyper-methylation profiles similar to the chondrocytes from which they are derived.", "In some embodiments, DNA methylation profiles of pluripotent or multipotent cells derived from chondrocytes are different from the DNA methylation profiles of pluripotent or multipotent cells derived from fibroblasts.", "In some embodiments, the DNA methylation pattern of pluripotent or multipotent cells derived from chondrocytes overlaps more with that of chondrocytes and embryonic stem cells and less with that of pluripotent or multipotent cells derived from fibroblasts.", "In some embodiments, markers of chondrogenic precursors and chondrocytes are greater expressed in pluripotent or multipotent cells derived from chondrocytes compared to pluripotent or multipotent cells derived from other cell types.", "In some embodiments, markers of chondrogenic precursors and chondrocytes include capthesin B, chondrocyte expressed protein-68 (CEP-68), type X collagen, type II collagen, aggrecan, Collagen 9, YKL-39, YKL-40, osteonectin, Sox9, annexin A6, CD44, CD151, type IV collagen, CRTAC1, DSPG3, FoxC1, FoxC2, IBSP/Sialoprotein II, ITM2A, Matrilin-3, Matrilin-4, MIA, OCIL, Otoraplin, Sox5, and URB.", "In some embodiments, the pluripotent or multipotent stem cells derived from chondrocytes, by the methods disclosed herein, are less than 20% positive for CD73 by FACS analysis.", "In some embodiments, the pluripotent or multipotent stem cells derived from chondrocytes, by the methods disclosed herein, are less than 15% positive for CD73 by FACS analysis.", "In some embodiments, the pluripotent or multipotent stem cells derived from chondrocytes, by the methods disclosed herein, are less than 10% positive for CD73 by FACS analysis.", "In some embodiments, the pluripotent or multipotent stem cells derived from chondrocytes, by the methods disclosed herein, are less than 5% positive for CD73 by FACS analysis.", "In some embodiments, the pluripotent or multipotent stem cells derived from chondrocytes, by the methods disclosed herein, are positive for expression of endogenous Oct3/4.In some embodiments, the pluripotent or multipotent stem cells derived from chondrocytes, by the methods disclosed herein, lack immunoreactivity to vimentin.", "In some embodiments, the pluripotent or multipotent stem cells derived from chondrocytes, by the methods disclosed herein express at least one of the following markers of pluripotent stem cells: ABCG2, cripto, CD9, FoxD3, Connexin43, Connexin45, Oct4, Sox2, Nanog, hTERT, UTF-1, ZFP42, SSEA-3, SSEA-4, Tra1-60, Tra1-81.In some embodiments, other markers for pluripotent stem cells include CD133, CD24, alkaline phosphatase, AFP, BMP-4, Brachyury, CD30, TDGF-1, GATA-4, GCTM-2, Genesis, Germ cell nuclear factor, HNF-4, N-CAM, Pax6, SCF, and telomerase.", "In some embodiments, the pluripotent or multipotent stem cells derived from chondrocytes, by the methods disclosed herein, are less than about 20% apoptotic.", "In some embodiments, the cells are less than about 10% apoptotic.", "In some embodiments, the cells are less than about 9% apoptotic, less than about 8% apoptotic, less than about 7% apoptotic, less than about 6% apoptotic, less than about 5% apoptotic, less than about 4% apoptotic, less than about 3% apoptotic, less than about 2% apoptotic, or less than about 1% apoptotic.", "Methods such as flow cytometry, fluorescence spectroscopy, and Tdt-Utp nick-end labeling (TUNNEL or TUNEL) assay, are used to assess the frequency of apoptosis in a given cell culture.", "Generating Chondrocytes from Chondrocyte-Derived Induced Pluripotent Stem Cells Disclosed herein, in some embodiments, is a method of generating a population of chondrocytes from a population of pluripotent or multipotent stem cells comprising: i) generating a population of pluripotent or multipotent stem cells according to the methods disclosed herein; ii) mechanically dissecting the pluripotent or multipotent stem cell colonies in order to produce cell aggregates; iii) culturing the cell aggregates in a tissue culture-treated vessel until confluency to produce aggregate-derived cells; iv) passaging the aggregate-derived cells in culture at least once to produce chondroprogenitors; and iv) culturing the chondroprogenitors in a three-dimensional culture; wherein the method does not comprise formation of an embryoid body.", "In some embodiments, the aggregate-derived cells are passaged at least two times.", "In some embodiments, the aggregate-derived cells are passaged at least three times.", "In some embodiments, the aggregate-derived cells are passaged at least four times.", "In some embodiments, the aggregate-derived cells are passaged at least five times.", "In some embodiments, the aggregate-derived cells are passaged at least six, seven, or eight.", "In some embodiments, the three-dimensional culture comprises TGF-β3.In some embodiments, the three-dimensional culture comprises BMP2.In some embodiments, the process of producing cell aggregates does not comprise enzymatic digestion of the pluripotent or multipotent stem cells.", "In some embodiments, the three dimensional culture comprises a three-dimensional matrix.", "In some embodiments, the three-dimensional matrix comprises collagen, proteoglycan, fibrin, hyaluronic acid, poly-D-lactide, poly-L-lactide, poly-DL-lactide, polyglycolic acid, polylactic acid, hydroxyapatite, calcium phosphate, aterocollagen, fibrin, alginate, agar and/or gelatin.", "In some embodiments, the three-dimensional matrix comprises collagen.", "In some embodiments, the collagen is cross-linked.", "In some embodiments, the collagen is solubilized.", "In some embodiments, the three-dimensional matrix comprises proteoglycan.", "In some embodiments, the tissue culture-treated vessel is plastic.", "In some embodiments, the tissue culture-treated vessel is polystyrene.", "In some embodiments, the pluripotent or multipotent stem cells derived from chondrocytes, by the methods disclosed herein, are passaged at least once.", "In some embodiments, the cells are passaged at least twice.", "In some embodiments, the cells are passaged at least three times.", "In some embodiments, the cells are passaged at least four times.", "In some embodiments, the cells are passaged at least five times.", "In some embodiments, the cells are passaged at least six times.", "In some embodiments, the cells are passaged at least seven times.", "In some embodiments, the cells are passaged at least eight times.", "In some embodiments, the cells are passaged at least nine times.", "In some embodiments, the cells are passaged at least ten times.", "In some embodiments, the cells are passaged at least twelve times.", "In some embodiments, the cells are passaged at least fifteen times.", "In some embodiments, the cells are passaged at least twenty times.", "In some embodiments, the cells are passaged at least twenty five times.", "In some embodiments, the cells are passaged at least thirty times.", "In some embodiments, the cells are passaged at least thirty five times.", "In some embodiments, disclosed herein is a population of cells, wherein the population of cells has been produced by a process comprising: i) generating a population of pluripotent or multipotent cells from a population of chondrocytes by directing expression of one or more of an Oct3/4, Sox2, Klf4 and c-Myc in the chondrocytes; ii) mechanically dissecting the pluripotent or multipotent cell colonies; iii) passaging the cells in culture at least once to produce chondroprogenitors; and iv) placing the chondroprogenitors in three-dimensional culture.", "In some embodiments, the population of cells is homogeneous.", "In some embodiments, the cells are passaged at least four times in order to produce chondroprogenitors.", "Three Dimensional Culture In some embodiments, the pluripotent or multipotent cells derived from chondrocytes by the methods disclosed herein are induced in culture to form chondrogenic precursors.", "In some embodiments, the pluripotent or multipotent cells derived from chondrocytes by the methods disclosed herein are associated in a three-dimensional format, such as a cell pellet.", "In some embodiments, the pluripotent or multipotent cells derived from chondrocytes by the methods disclosed herein are associated in a monolayer.", "In some embodiments, the three dimensional format contributes to the in vitro chondrogenesis of the pluripotent or multipotent cells derived from chondrocytes by the methods disclosed herein.", "In some embodiments, the pluripotent or multipotent cells derived from chondrocytes by the methods disclosed herein are cultured condensed together, for example, as a packed or pelleted cell mass under gentle centrifugation.", "In some embodiments, the chondrocyte-derived pluripotent or multipotent cells are embedded in a matrix gel material.", "In some embodiments, the matrix gel material comprises one of more of the components: proteoglycans, GAGs, fibers and functional proteins.", "In some embodiments, the matrix gel material comprises collagen and proteoglycan.", "Collagen (e.g., Type II collagen, Type III collagen, Type IV collagen, Type V collagen, Type VI collagen, Type VIII collagen, Type IX collagen, Type X collagen, or mixtures thereof) is not particularly limited.", "In some embodiments, the matrix gel comprises Type I and Type II collagen.", "In some embodiments, Type II collagen is used.", "In some embodiments, the collagen is atelocollagen.", "In some embodiments, the collagen is low molecular weight collagen hydrolyzed with enzyme.", "In some embodiments, the collagen is human-derived collagen or collagen derived from rabbits, cattle, horses or mice.", "In some embodiments, the matrix gel material comprises at least one proteoglycan.", "In some embodiments, the proteoglycan is preferably composed of a core protein with pending glycosaminoglycan (GAG) molecules.", "Suitable GAGs are for instance hyaluronic acid, chondroitin-4-sulfate, chondroitin-6-sulphate, dermatan sulphate, heparin sulphate, heparin sulphate, and keratan sulphate.", "In some embodiments a GAG molecule is linked to the core protein via a trisaccharide linker (e.g.", "a GalGalXyl-linker).", "Exemplary proteoglycans include, but are not limited to, decorin, biglycan, versican and aggrecan.", "In some embodiments, the proteoglycans are interconnected by hyaluronic acid molecules.", "In some embodiments, multiple proteoglycans are attached to a single hyaluronic acid backbone.", "In some embodiments, the ratio of collagen to proteoglycan is in the range of about 0.3 to about 1.1 relative to about 1 of collagen in weight ratio.", "In some embodiments, the proteoglycan is in the range of about 0.5 to about 0.7 relative to about 1 of collagen.", "In some embodiments, the matrix gel material further comprises one or more functionality-providing proteins such as: glycoproteins such as laminin, entactin, tenascin fibrillin or fibronectin, osteocalcin (GIa protein), osteonectin, and sialoproteins, such as bone sialoprotein (BSP), osteopontin (OPN), dentin matrix protein-1 (DMP1), dentin sialophosphoprotein (DSPP) and matrix extracellular phosphoglycoprotein (MEPE), or any combinations thereof.", "In some embodiments, the total amount of protein is 1-90 wt %, based on the total weight of the gel matrix material.", "As culture media for the chondrocyte-derived pluripotent or multipotent cells, it is possible to use the media and additives used for the ordinary culture of the chondrocytes or the mesenchymal cells without limitation.", "In some embodiments, the culture medium is selected from: RPMI1647, RPMI1640, MEM, BME, 5A, DM120, RITC80-7, F12, L-15, MCDB104 and MCDB107.In some embodiments, the culture medium further comprises serum.", "In some embodiments, the concentration of the serum is between 1 to 20%.", "In some embodiments, the concentration of serum is in the range of 5 to 15%.", "In some embodiments, the concentration of serum is in the range of 5 to 10%.", "In some embodiments, the serum is bovine serum, fetal calf serum or horse serum.", "In some embodiments, collagen and proteoglycan are mixed in the medium at an aforementioned predetermined ratio, and are desirably used in the range of the concentration at which they can be gelled and form the three-dimensional structure.", "In some embodiments, the concentration of collagen is 0.8 to 2.4% by weight and 1.2 to 2.0% by weight, and the concentration of proteoglycan is 0.4 to 1.2% by weight and 0.6 to 1.0% by weight.", "In some embodiments, the total concentration of collagen and proteoglycan is about 1.2 to 3.6% by weight and preferably about 1.8 to 3.0% by weight.", "In some embodiments, chondrocyte-derived pluripotent or multipotent cells are cultured in the presence of chondrogenic growth factors.", "In some embodiments, chondrogenic growth factors are selected from transforming growth factor-β3 (TGF-β3), transforming growth factor-β1 (TGF-β1), insulin-like growth factor 1 (IGF-1), and basic fibroblast growth factor (bFGF).", "In some embodiments, the chondrocyte-derived iPS cells are cultured in the presence of TGF-β3.In some embodiments, the culture medium also comprises dexamethasone and high glucose.", "In some embodiments, chondrocyte-specific gene expression is increased in response to TGF-03 treatment.", "In some embodiments, the chondrocyte-specific genes are selected from collagen type 2A1 and aggrecan expression.", "In some embodiments, markers of chondrogenic precursors and chondrocytes include capthesin B, chondrocyte expressed protein-68 (CEP-68), type X collagen, type II collagen, aggrecan, Collagen 9, YKL-39, YKL-40, osteonectin, Sox9, annexin A6, CD44, CD151, type IV collagen, CRTAC1, DSPG3, FoxC1, FoxC2, IBSP/Sialoprotein II, ITM2A, Matrilin-3, Matrilin-4, MIA, OCIL, Otoraplin, Sox5, and URB.", "In some embodiments, disclosed herein is a population of cells, wherein the population of cells comprises the following characteristics: a) at least 75% of the population of cells is positive for CD73 by FACS analysis; b) at least 75% of the population of cells is positive for CD105 by FACS analysis; c) immunopositive for vimentin; and d) reduced level of Oct3/4 expression.", "In some embodiments, the population of cells is homogeneous.", "In some embodiments, the cells are less than about 20% apoptotic.", "In some embodiments, the cells are less than about 10% apoptotic.", "In some embodiments, the cells are less than about 9% apoptotic, less than about 8% apoptotic, less than about 7% apoptotic, less than about 6% apoptotic, less than about 5% apoptotic, less than about 4% apoptotic, less than about 3% apoptotic, less than about 2% apoptotic, or less than about 1% apoptotic.", "Methods such as flow cytometry, fluorescence spectroscopy, and Tdt-Utp nick-end labeling (TUNNEL or TUNEL) assay, are used to assess the frequency of apoptosis in a given cell culture.", "Generating Cardiomyocytes from Chondrocyte-Derived Induced Pluripotent Stem Cells The pluripotent or multipotent cells derived from chondrocytes by the methods disclosed herein may also be differentiated into cardiac muscle cells.", "In some embodiments, disclosed herein is method of generating a population of cardiomyocytes from a population of pluripotent or multipotent cells comprising: i) generating a population of pluripotent or multipotent cells according to the methods disclosed herein; ii) allowing the population of pluripotent or multipotent stem cells to form embryoid bodies in a culture medium; iii) adding BMP4 to the culture medium; iv) adding BMP4, Activin A, and FGF-β for days 1-3 after step iii); v) adding DKK and VEGF for days 3-8 after step iii); and vi) adding DKK, VEGF, and FGF-β for days 8-14 after step iii).", "In some embodiments, on day 0, from about 1 ng/ml to about 10 ng/ml of BMP4 is added to the culture medium.", "In some embodiments, on day 0, about 5 ng/ml of BMP4 is added to the culture medium.", "In some embodiments, on day 1, from about 5 ng/ml to about 20 ng/ml of BMP, from about 1 ng/ml to about 10 ng/ml of Activin A, and from about 1 ng/ml to about 10 ng/ml of FGF-beta are added to the culture medium.", "In some embodiments, on day 1, about 10 ng/ml of BMP4, about 6 ng/ml of Activin A, and about 5 ng/ml of FGF-beta are added to the culture medium.", "In some embodiments, on day 3, from about 50 ng/ml to about 300 ng/ml of DKK and from 1 ng/ml to about 10 ng/ml of VEGF are added to the culture medium.", "In some embodiments, on day 3, about 150 ng/ml of DKK and about 5 ng/ml of VEGF are added to the culture medium.", "In some embodiments, on day 8, from about 50 ng/ml to about 300 ng/ml of DKK, from about 1 ng/ml to about 20 ng/ml of VEGF, and from about 1 ng/ml to about 10 ng/ml of FGF-beta are added to the culture medium.", "In some embodiments, on day 8, about 150 ng/ml of DKK, about 10 ng/ml of VEGF and about 5 ng/ml of FGF-beta are added to the culture medium.", "Uses of Chondrogenic Precursors Derived from Chondrocyte-Derived Induced Pluripotent Stem Cells Disclosed herein, in certain embodiments, are methods of regenerating cartilaginous tissue.", "In some embodiments, the cartilaginous tissue is auricular cartilage, costal cartilage, articular cartilage, intervertebral cartilage, or tracheal cartilage.", "Provided herein, in some embodiments, is a method of treating a bone or cartilage defect, comprising transplanting a population of cells, as produced by the methods disclosed herein (e.g.", "a population of pluripotent or multipotent cells derived from chondrocytes and/or a population of chondrocytes or chondroprogenitors derived from a population of pluripotent or multipotent cells derived from chondrocytes), to the bone or cartilage defect.", "In some embodiments, new tissue is produced.", "In some embodiments, the new tissue integrates with the tissue of the bone or cartilage defect.", "In some embodiments, the new tissue restores the surface of the cartilage or bone.", "In some embodiments, the new tissue comprises collagen type II.", "In some embodiments, the new tissue comprises superficial, intermediate, and deep zones characteristic of normal articular cartilage.", "In some embodiments, the superficial zone of the new tissue comprises lubricin.", "Disclosed herein, in some embodiments, is a method of regenerating cartilaginous tissue, comprising transplanting a population of cells, as produced by the methods disclosed herein (e.g.", "a population of pluripotent or multipotent cells derived from chondrocytes and/or a population of chondrocytes or chondroprogenitors derived from a population of pluripotent or multipotent cells derived from chondrocytes), to a bone or cartilage defect, wherein new cartilaginous tissue is produced.", "In some embodiments, the population of cells is transplanted into a bone or cartilage defect in a subject in need thereof.", "In some embodiments, the new cartilaginous tissue integrates with the tissue of the bone or cartilage defect.", "In some embodiments, the new cartilaginous tissue restores the surface of the cartilage or bone.", "In some embodiments, the new cartilaginous tissue comprises collagen type II.", "In some embodiments, the new cartilaginous tissue comprises superficial, intermediate, and deep zones characteristic of normal articular cartilage.", "In some embodiments, the superficial zone of the new cartilaginous tissue comprises lubricin.", "In some embodiments, the new cartilaginous tissue does not comprise teratomas, neoplastic cells, evidence of deformation, abnormal architectural features, or other inappropriate cell types.", "Cartilage Therapy Material In some embodiments, the chondrocytes or chondroprogenitors obtained by methods disclosed herein are used for methods of regenerating cartilaginous tissue.", "In some embodiments, the chondrogenic precursors disclosed herein are placed directly into an area of bone or cartilage defect.", "In some embodiments, the chondrogenic precursors are placed into an area of bone or cartilage defect with supportive biomaterial.", "In some embodiments, new cartilaginous tissue products by the chondrocytes obtained by the invention integrates with the tissue of the bone or cartilage defect.", "In some embodiments, the new cartilaginous tissue restores the surface of the cartilage or bone.", "In some embodiments, the new cartilaginous tissue comprises collagen type II.", "In some embodiments, the new cartilaginous tissue comprises superficial, intermediate, and deep zones characteristic of normal articular cartilage.", "In some embodiments, the superficial zone of the new cartilaginous tissue comprises lubricin.", "In some embodiments, the new cartilaginous tissue does not comprise teratomas, neoplastic cells, evidence of deformation, abnormal architectural features, or other inappropriate cell types.", "Disclosed herein, in some embodiments, are methods of repairing or treating cartilage defects in articular joint surfaces in a subject in need thereof comprising administering to the subject a population of cells, as described herein, at the site of a cartilage defect.", "In some embodiments, the method also comprises administration to the subject at the site of the cartilage defect an agent or device to block vascular invasion.", "In some embodiments, a cell-free barrier is placed at the cartilage defect in order to keep the population of cells in place.", "Disclosed herein, in some embodiments, is a method of treating a cartilage-related disorder, comprising administration of a population of cells, as described herein (e.g.", "a population of pluripotent or multipotent cells derived from chondrocytes and/or a population of chondrocytes or chondroprogenitors derived from a population of pluripotent or multipotent cells derived from chondrocytes), to a site of cartilage injury or defect in a subject in need thereof.", "In some embodiments, the cartilage-related disorder is articular cartilage trauma, meniscus injury, a chonodrogenesis disorder, arthritis, chondropathy, chondrosarcoma, chondromalacia, polychondritis, relapsing polychondritis, slipped epiphysis, osteochondritis dissecans, chondrodysplasia, costochondritis, osteochondroma, spondylosis, osteochondroses, Tietze syndrome, dermochondrocorneal dystrophy of Francois, epiphyseal dysplasia, carpotarsal osteochondromatosis, achondropasia, chondrocalcinosis, genochondromatosis, chondroma, achondrogenesis, echondromata, hyprochondroplasia, and Keutel syndrome.", "In some embodiments, the cartilage-related disorder is arthritis.", "In some embodiments, the arthritis is osteoarthritis.", "In some embodiments, the osteoarthritis occurs in the knee, finger, wrist, hip, spine, shoulder, elbow, toe, ankle, or neck of a subject.", "Disclosed herein, in some embodiments, is a cartilage repair implant comprising a biomaterial and a population of cells as described herein (e.g.", "a population of pluripotent or multipotent cells derived from chondrocytes and/or a population of chondrocytes or chondroprogenitors derived from a population of pluripotent or multipotent cells derived from chondrocytes).", "In some embodiments, the chondrogenic precursors are frozen for storage.", "Freezing can be accomplished under varying conditions and in the presence of various agents or protective compounds.", "Thus, in some embodiments, freezing is performed in the presence of dimethyl sulfoxide (“DMSO”).", "DMSO is a well-known protective agent which is inserted into cellular membranes and enables them to be stabilized, which prevents cells from being destroyed.", "In some embodiments, freezing is performed in the absence of DMSO.", "In some embodiments, the chondrogenic precursors are integrated into a biomaterial prior to transplant.", "Examples of biomaterials into which chondrogenic precursors or their cell mass may be integrated include: collagen, polyglycolic acid (PGA), polylactic acid, alginates (for example, the calcium salt), polyethylene oxide, fibrin adhesive, polylactic acid-polyglycolic acid copolymer, proteoglycans, glycosaminoglycans, human dermis, or a combination thereof.", "In some embodiments, proteoglycans and glycosaminoglycans are sulfated.", "In some embodiments, the biomaterials is a membrane such as sheet, porous bodies such as sponges, meshes such as knits, textiles, non-woven fabrics, cotton and the like.", "In some embodiments, the biomaterial is porous material.", "In some embodiments, the biomaterial comprises collagen.", "In some embodiments, the collagen is cross-linked.", "In some embodiments, the cross-linked collagen is stably fixed to the body of the recipient by a staple or the like.", "In some embodiments, the collagen is solubilized to form a collagen solution for admixture with the chondrocytes, and the mixture gelled, if necessary, for use as a cartilage therapy material.", "In some embodiments, conventional collagen solutions are used.", "In some embodiments, an enzyme-solubilized collagen solution is used.", "In some embodiments, a cartilage therapy material is formed by integrating or overlaying a mixture of collagen solution and chondrocytes into or onto a sponge, non-woven fabric or the like.", "In some embodiments, the cartilage therapy material is administered with an agent that prevents or reduces vascularization.", "Examples of agents that prevent or reduce vascularization include, but are not limited to, tyrosine kinase inhibitors, such as inhibitors of the tyrosine kinase receptors Flt-1 (VEGFR1) and Flk-1/KDR (VEGFR2), inhibitors of epidermal-derived, fibroblast-derived, or platelet derived growth factors, MMP (matrix metalloprotease) inhibitors, integrin blockers, interferon-α, interleukin-12, pentosan polysulfate, cyclooxygenase inhibitors, including nonsteroidal anti-inflammatories (NSAEDs) like aspirin and ibuprofen as well as selective cyclooxy-genase-2 inhibitors like celecoxib and rofecoxib steroidal anti-inflammatories (such as corticosteroids, mineralocorticoids, dexamethasone, prednisone, prednisolone, methylpred, betamethasone), carboxyamidotriazole, combretastatin A-4, squalamine, 6-O-chloroacetyl-carbonyl)-fumagillol, thalidomide, angiostatin, troponin-1, angiotensin II antagonists, and antibodies to VEGF.", "In some embodiments, the cartilage therapy material forms cartilage tissue and induces cartilaginous ossification.", "Human dermis is an example of such a material which induces cartilaginous ossification.", "In some embodiments, ossification is also promoted by a growth factor which promotes bone formation, such as bone morphogenetic protein (BMP).", "Prior to transplantation of the described cartilage therapy materials, it is preferable to prepare the area that is to be treated.", "For this purpose, the defect must be prepared to ensure that the implant will take more effectively (particularly as regards its attachment), to reduce the risks of vascularization, etc.", "Generally, the defect is treated in advance (in order to eliminate all defective cartilage from the area), then it is cleaned.", "Next, various implantation techniques can be implemented, according to the material being implanted (suspension, matrix, cartilage reconstituted in vitro).", "Generally, implantation of the described cartilage therapy materials can be performed by applying various surgical techniques known to the skilled person, and which are experienced in a human clinic, notably implying a stage in which the implant is affixed during surgery, through biodegradable sutures or by the application of bioadhesives.", "Examples of bioadhesives include, notably, biological glues made of fibrin and/or thrombin, or other biocompatible materials.", "More particularly, the resorbable biocompatible film is affixed onto the area to be treated, by means of a biological or biocompatible glue.", "In a preferred variant, the film is positioned on the cartilaginous defect, then the pocket which is thus constituted is filled with cartilage therapy material.", "EXAMPLES Example 1: Transduction of Human Chondrocytes with Lenti-Smart-hOKSM to Establish iPSC Line Derivation Method: pLenti-Smart-hOKSM from InvivoGen, the Genes Oct4, Sox2, Klf4 and c-Myc 293FT-P4 cells were thawed, cultured and passed in DMEM containing 10% FBS, 4.5 g/l glucose, 50 U/ml penicillin, 50 μg/ml streptomycin, 1 mM sodium pyruvate, 4 mM L-glutamine and 0.1 mM non-essential amino acids.", "Cells were grown at 37° C. in a humidified 5% CO2 incubator.", "These cells were split every 1-2 days when they reached 70-80% confluency.", "Cells were not allowed to reach 90% confluency.", "For subculturing, cells were detached with trypsin/EDTA, and split at a ratio of 1:3-1:10.Production of Lentiviral Vectors Using HEK 293T Cells The OKSM plasmid was provided at a concentration of 1 μg/μl in water.", "188 μl of sterile water was added to a 12 μl aliquot of pLV-OSKM.", "This 200 μl solution containing the 12 μg of pLV-OSKM was used to rehydrate the LENTI-Smart™.", "LENTI-Smart™ was removed from −20° C. and pre-warmed at room temperature for 10 minutes.", "The 200 μl solution was added to the LENTI-Smart™ and mixed by gently tapping the bottom of the tube.", "The mixture was incubated at room temperature for 15 minutes.", "The total volume was brought up to 1 ml, by adding 800 μl of sterile water and mixed well by gently tapping the bottom of the tube.", "HEK 293T cells were trypsinized, and 1×107 HEK 293T cells were added to a T-75 cm2 flask in 12 ml of pre-warmed DMEM containing 10% FBS.", "The T-75 cm2 flask upright was kept upright.", "The 1 ml of resuspended LENTI-Smart™ was added gently and directly onto cells and homogenized thoroughly by pipetting up and down several times.", "The T-75 cm2 flask containing HEK 293T cells and LENTI-Smart™ was incubated horizontally at 37° C., 5% CO2.After twelve to sixteen hours, the culture medium was discarded from the HEK 293T cells and replaced with 12 ml of pre-warmed fresh medium to further incubate the HEK 293T cells at 37° C., 5% CO2.Note: As a visual control, cells were fused and multinucleated thirty-six to forty-eight hours after transfection, due to the presence of the VSV-G protein.", "This morphological change was expected and did not affect the production of lentiviral vectors.", "Lentiviral supernatant was harvested as follows: supernatants were pooled and collected, and cell debris was removed by centrifugation for 5 minutes at 2000 rpm.", "Supernatants were filtered using a 0.45 μm filter in order to remove viral capsid debris.", "The filter was made of PVDF (low protein binding), instead of nitrocellulose.", "Hour 0: Transfection Hour 12: Change medium Hour 36: 1st harvest Hour 48: 2nd harvest Hour 60: 3rd harvest Transduction Procedure Day 0: Human chondrocyte P2 cells were seeded at appropriate density in a 6-well plate (˜5×104).", "Cells were plated such that cell density was ˜25-50% confluent at the time of transduction.", "Day 1: Transduction.", "Medium was removed from the tissue culture plate by aspiration and replaced with 2-3 ml of iPSC reprogram factor lentiviral mixture, as described from above, with an additional 8 μg/ml polybrene.", "The tissue culture plate was spun in a desktop centrifuge (e.g.", "Sorvall RT6000) at 1,000×g for 60 min at room temperature to increase transduction efficiency, and the plate was incubated overnight at 37° C. Day 2: The transduction medium was replaced with 2-3 ml of fresh DMEM medium.", "Day 3-4: Medium was replaced.", "Some cell death was observed due to c-Myc induced apoptosis.", "Day 4: HS27 MEF feeder cells and gelatin-coated plates.", "(2.4×106 cells/plate) were prepared, in incomplete ES medium Day 5: Cells were trypsinized and plated out on 10 cm gelatin-coated plates, one 6 well to two 10 cm plates, and cultured with hESC media, one set with PEDF (Peprotech, 100 ng/ml) without FGFb, the other set with FGFb (16 ng/ml, R&D) only, both with 1 mM valproic acid.", "Medium was changed every day and the plates were observed under the microscope to identify ES like colonies.", "Incomplete Human iPSC serum-free medium (500 ml, filtered with 0.22 μm filter): 1.Knockout serum replacement 100 ml 20% final 2.Penicillin/Streptomycin 5 ml 100 U and 100 μg per ml final 3.L-glutamine (200 mM) 5 ml 2 mM final 4.Non-essential Amino 88Acids 5 ml 100 μM final 5.2-mercaptoethanol (55 mM) 0.9 ml 100 μM final 6.DMEM/F12 fill to 500 ml After the colonies were selected, the colonies were maintained and expanded in regular human ES medium for further experiments.", "Example 2: Differentiation of iPSC Cells into Chondroprogenitors Chondroprogenitors were differentiated from iPSC or a human embryonic stem cell (hESC) (WAO9, Wicell) by culturing in DMEM/F12 containing 10% FBS.", "Chondrogenic differentiation of chondroprogenitors were done in pellet culture by spinning down 5×105 cells to form a pellet and cultured in chondrogenic media (Lonza) containing TGFβ3 with or without BMP4.After 2 weeks, type II collagen expression in these pellets was verified with qPCR.", "A partial thickness defect (2 mm) was surgically created in trochlear surfaces of rabbit knees.", "Chondroprogenitors differentiated from chondrocyte-derived iPSC cell lines were transplanted into this defect.", "After 8 weeks, tissue was harvested, fixed with zinc-formalin, embedded in paraffin, sectioned and stained with Safranin-O/Fast Green.", "The defects in the rabbit knees became filled with Safranin O staining positive extracellular matrix (FIG.", "4).", "Example 3: Repairing Cartilage Defects in Explants from Adult Human Arthritic Joints by Transplantation Osteochondral specimens are surgically resected from the joints of adult arthritic human patients undergoing total knee replacement.", "Six-mm diameter cylindrical plugs are cored out.", "A surgical curette is used to make partial-thickness defects approximately 2 mm in size in the articular surface.", "The defects are filled with chondrogenic precursors produced from chondrocyte-derived iPS cells, which are aggregated under the following mechanical pressures: 5×105 cells centrifuged in 15-ml conical tubes at 150 g for 5 min in DMEM/F12 supplemented with 10% FBS and incubated overnight in the presence or absence of TGFß3.After 4 weeks, explants are fixed, paraffin-embedded, sectioned, and stained with Safranin O for immunohistochemical examination.", "Example 4: Repairing Cartilage Defects in Adult Human Arthritic Joints by Intraarticular Injection A patient with osteoarthritis of the knee is injected in an arthritic knee joint with cells according to the invention (e.g., a population of pluripotent or multipotent cells derived from chondrocytes and/or a population of chondrocytes or chondroprogenitors derived from a population of pluripotent or multipotent cells derived from chondrocytes) suspended in alginate.", "Maintenance injections are given as needed.", "Example 5: Repairing Cartilage Defects in Adult Human Arthritic Joints by Surgical Implantation A patient with osteoarthritis of the knee or with a cartilage and/or a bone defect is treated by surgically implanting cells according to the invention (e.g., a population of pluripotent or multipotent cells derived from chondrocytes and/or a population of chondrocytes or chondroprogenitors derived from a population of pluripotent or multipotent cells derived from chondrocytes) and matrix.", "While preferred embodiments of the present invention have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only.", "Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the invention.", "It should be understood that various alternatives to the embodiments of the invention described herein may be employed in practicing the invention.", "It is intended that the following claims define the scope of the invention and that methods and structures within the scope of these claims and their equivalents be covered thereby." ] ]
Patent_15872577
[ [ "BROADCAST SIGNAL TRANSMITTING APPARATUS, BROADCAST SIGNAL RECEIVING APPARATUS, METHOD FOR TRANSMITTING BROADCAST SIGNAL, AND METHOD FOR RECEIVING BROADCAST SIGNAL", "An apparatus for receiving a broadcast signal, includes a receiver configured to receive the broadcast signal including physical layer signaling data, signaling data, content data and service guide information, wherein the signaling data is included in a signal frame indicated by the physical layer signaling data, wherein the signaling data includes mapping information between a service and a PLP, and information supporting channel scanning and service acquisition, wherein the service guide information includes a service fragment having information about the broadcast service and a content fragment having information about content data of the broadcast service, wherein the content fragment further includes a content-level PrivateExt element having component information of the content data, wherein the component information includes information for a component in the broadcast service, and wherein the component is one of a video component, an audio component, and a closed caption component (CC)." ], [ "1.An apparatus for receiving a broadcast signal, the apparatus comprising: a receiver configured to receive the broadcast signal including physical layer signaling data, signaling data, content data and service guide information, wherein the signaling data is included in a signal frame indicated by the physical layer signaling data, wherein the signaling data includes mapping information between a service and a PLP, and information supporting channel scanning and service acquisition, wherein the service guide information includes a service fragment having information about the broadcast service and a content fragment having information about content data of the broadcast service, wherein the content fragment further includes a content-level PrivateExt element having component information of the content data, wherein the component information includes information for a component in the broadcast service, and wherein the component is one of a video component, an audio component, and a closed caption component (CC); a signaling decoder configured to decode the physical layer signaling data, wherein the mapping information and the information supporting channel scanning and service acquisition are further decoded from the signal frame based on the decoded physical layer signaling data; a decoder configured to decode the content data and the service guide information; a display screen configured to display an image representing that an application-based (App-based) service is available for the broadcast service; and a user input interface to detect a user input, wherein when the user input selecting the displayed image representing the App-based service is detected, an application for the App-based service is displayed on the display screen.", "2.The apparatus of claim 1, wherein the service fragment includes service type information indicating a type of the broadcast service, and wherein the type of the broadcast service includes a Linear Service for providing content in real time or the App-based Service based on an application.", "3.The apparatus of claim 1, wherein the component information includes a component role information indicating a role of the component and a language information representing a language in which the component is available.", "4.The apparatus of claim 3, wherein the role of the component is at least one of a three dimensional (3D) video left or right view, a 3D video depth information, a music audio and a dialog audio.", "5.A method of receiving a broadcast signal, the method comprising: receiving the broadcast signal including physical layer signaling data, signaling data, content data and service guide information, wherein the signaling data is included in a signal frame indicated by the physical layer signaling data, wherein the signaling data includes mapping information between a service and a PLP, and information supporting channel scanning and service acquisition, wherein the service guide information includes a service fragment having information about the broadcast service and a content fragment having information about content data of the broadcast service, wherein the content fragment further includes a content-level PrivateExt element having component information of the content data, wherein the component information includes information for a component in the broadcast service, and wherein the component is one of a video component, an audio component, and a closed caption component (CC); decoding the physical layer signaling data, wherein the mapping information and the information supporting channel scanning and service acquisition are further decoded from the signal frame based on the decoded physical layer signaling data; decoding the content data and the service guide information; displaying an image representing that an application-based (App-based) service is available for the broadcast service; detecting a user input selecting the displayed image representing the App-based service; and displaying an application for the App-based service on a display screen.", "6.The method of claim 5, wherein the service fragment includes service type information indicating a type of the broadcast service, and wherein the type of the broadcast service includes a Linear Service for providing content in real time or the App-based Service based on an application.", "7.The method of claim 5, wherein the component information includes a component role information indicating a role of the component and a language information representing a language in which the component is available.", "8.The method of claim 7, wherein the role of the component is at least one of a three dimensional (3D) video left or right view, a 3D video depth information, a music audio and a dialog audio." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>That is, a digital broadcast system can provide HD (high definition) images, multi-channel audio and various additional services.", "However, data transmission efficiency for transmission of large amounts of data, robustness of transmission/reception networks and network flexibility in consideration of mobile reception equipment need to be improved for digital broadcasting.", "The object of the present invention can be achieved by providing a method of transmitting a broadcast signal, including generating service guide information including access information of a broadcast service and content data, wherein the service guide information includes a service fragment indicating information about the broadcast service, encoding the generated service guide information and content data, and transmitting the encoded service guide information and content data.", "The service fragment may include service type information indicating type of the broadcast service, and the type of the broadcast service indicated by the service type information may include at least one of a linear service (Linear Service) that provides broadcast schedule information, an application based service (Appbased Service), and a companion screen service (CompanionScreen Service) using a companion device.", "The service guide information may include a component fragment indicating information about a component included in the broadcast service, and the component fragment may include at least one of information that identifies the component fragment, component type information indicating type of the component, and component role information indicating role of the component.", "The type of the component indicated by the component type information may include at least one of a continuous component (Continuous component) indicating a component represented in one continuous stream, an elementary component (Elementary component) indicating an independently encoded component, a composite component (Composite component) indicating a component that can be combined for one presentation, and a pick-one component (PickOne component) indicating a component selected for one presentation.", "The component role information may indicate that the component performs at least one role of a base layer for scalable video encoding, an enhancement layer for scalable video encoding, a left-eye image of 3D video, a right-eye image of 3D video, depth information of 3D video, music audio, dialog audio, and caption for children.", "In accordance with another aspect of the present invention, an apparatus for receiving a broadcast signal includes a receiver configured to receive service guide information including access information of a broadcast service and content data, wherein the service guide information includes a service fragment indicating information about the broadcast service, and a decoder configured to decode the received service guide information and content data.", "The service fragment may include service type information indicating type of the broadcast service, and the type of the broadcast service indicated by the service type information may include at least one of a linear service (Linear Service) that provides broadcast schedule information, an application based service (Appbased Service), and a companion screen service (CompanionScreen Service) using a companion device.", "The service guide information may include a component fragment indicating information about a component included in the broadcast service, and the component fragment may include at least one of information that identifies the component fragment, component type information indicating type of the component, and component role information indicating role of the component.", "The type of the component indicated by the component type information may include at least one of a continuous component (Continuous component) indicating a component represented in one continuous stream, an elementary component (Elementary component) indicating an independently encoded component, a composite component (Composite component) indicating a component that can be combined for one presentation, and a pick-one component (PickOne component) indicating a component selected for one presentation.", "The component role information may indicate that the component performs at least one role of a base layer for scalable video encoding, an enhancement layer for scalable video encoding, a left-eye image of 3D video, a right-eye image of 3D video, depth information of 3D video, music audio, dialog audio, and caption for children.", "In accordance with another aspect of the present invention, an apparatus for transmitting a broadcast signal includes a generator configured to generate service guide information including access information of a broadcast service and content data, wherein the service guide information includes a service fragment indicating information about the broadcast service, an encoder configured to encode the generated service guide information and content data, and a transmitter configured to transmit the encoded service guide information and content data.", "The service fragment may include service type information indicating type of the broadcast service, and the type of the broadcast service indicated by the service type information may include at least one of a linear service (Linear Service) that provides broadcast schedule information, an application based service (Appbased Service), and a companion screen service (CompanionScreen Service) using a companion device.", "In accordance with another aspect of the present invention, a method of receiving a broadcast signal includes receiving service guide information including access information of a broadcast service and content data, wherein the service guide information includes a service fragment indicating information about the broadcast service, and decoding the received service guide information and content data.", "The service fragment may include service type information indicating type of the broadcast service, and the type of the broadcast service indicated by the service type information may include at least one of a linear service (Linear Service) that provides broadcast schedule information, an application based service (Appbased Service), and a companion screen service (CompanionScreen Service) using a companion device.", "The service guide information may include a component fragment indicating information about a component included in the broadcast service, and the component fragment may include at least one of information that identifies the component fragment, component type information indicating type of the component, and component role information indicating role of the component.", "As is apparent from the above description, the embodiments of the present invention can process data according to service characteristics to control QoS (Quality of Service) for each service or service component, thereby providing various broadcast services.", "The embodiments of the present invention can achieve transmission flexibility by transmitting various broadcast services through the same radio frequency (RF) signal bandwidth.", "The embodiments of the present invention can improve data transmission efficiency and increase robustness of transmission/reception (Tx/Rx) of broadcast signals using a MIMO (Multiple Input Multiple Output) system.", "The embodiments of the present invention can provide a method and apparatus, which are configured to receive digital broadcast signals without errors even with mobile reception equipment or in an indoor environment, for transmitting and receiving broadcast signals." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This Application is a Continuation of co-pending U.S. patent application Ser.", "No.", "15/115,567 filed on Jul.", "29, 2016, which is the National Phase of PCT International Application No.", "PCT/KR2015/004171 filed on Apr.", "27, 2015, which claims the benefit under 35 U.S.C.", "§ 119(e) to U.S.", "Provisional Application Nos.", "62/003,039 filed on May 27, 2014, 62/000,515 filed on May 19, 2014, 61/991,624 filed on May 12, 2014 and 61/984,854 filed on Apr.", "27, 2014, all of which are hereby expressly incorporated by reference into the present application.", "BACKGROUND OF THE INVENTION Field of the Invention The present invention relates to an apparatus for transmitting broadcast signals, an apparatus for receiving broadcast signals, and methods for transmitting and receiving broadcast signals.", "Discussion of the Related Art As analog broadcast signal transmission comes to an end, various technologies for transmitting/receiving digital broadcast signals are being developed.", "A digital broadcast signal may include a larger amount of video/audio data than an analog broadcast signal and may further include various types of additional data in addition to the video/audio data.", "SUMMARY OF THE INVENTION That is, a digital broadcast system can provide HD (high definition) images, multi-channel audio and various additional services.", "However, data transmission efficiency for transmission of large amounts of data, robustness of transmission/reception networks and network flexibility in consideration of mobile reception equipment need to be improved for digital broadcasting.", "The object of the present invention can be achieved by providing a method of transmitting a broadcast signal, including generating service guide information including access information of a broadcast service and content data, wherein the service guide information includes a service fragment indicating information about the broadcast service, encoding the generated service guide information and content data, and transmitting the encoded service guide information and content data.", "The service fragment may include service type information indicating type of the broadcast service, and the type of the broadcast service indicated by the service type information may include at least one of a linear service (Linear Service) that provides broadcast schedule information, an application based service (Appbased Service), and a companion screen service (CompanionScreen Service) using a companion device.", "The service guide information may include a component fragment indicating information about a component included in the broadcast service, and the component fragment may include at least one of information that identifies the component fragment, component type information indicating type of the component, and component role information indicating role of the component.", "The type of the component indicated by the component type information may include at least one of a continuous component (Continuous component) indicating a component represented in one continuous stream, an elementary component (Elementary component) indicating an independently encoded component, a composite component (Composite component) indicating a component that can be combined for one presentation, and a pick-one component (PickOne component) indicating a component selected for one presentation.", "The component role information may indicate that the component performs at least one role of a base layer for scalable video encoding, an enhancement layer for scalable video encoding, a left-eye image of 3D video, a right-eye image of 3D video, depth information of 3D video, music audio, dialog audio, and caption for children.", "In accordance with another aspect of the present invention, an apparatus for receiving a broadcast signal includes a receiver configured to receive service guide information including access information of a broadcast service and content data, wherein the service guide information includes a service fragment indicating information about the broadcast service, and a decoder configured to decode the received service guide information and content data.", "The service fragment may include service type information indicating type of the broadcast service, and the type of the broadcast service indicated by the service type information may include at least one of a linear service (Linear Service) that provides broadcast schedule information, an application based service (Appbased Service), and a companion screen service (CompanionScreen Service) using a companion device.", "The service guide information may include a component fragment indicating information about a component included in the broadcast service, and the component fragment may include at least one of information that identifies the component fragment, component type information indicating type of the component, and component role information indicating role of the component.", "The type of the component indicated by the component type information may include at least one of a continuous component (Continuous component) indicating a component represented in one continuous stream, an elementary component (Elementary component) indicating an independently encoded component, a composite component (Composite component) indicating a component that can be combined for one presentation, and a pick-one component (PickOne component) indicating a component selected for one presentation.", "The component role information may indicate that the component performs at least one role of a base layer for scalable video encoding, an enhancement layer for scalable video encoding, a left-eye image of 3D video, a right-eye image of 3D video, depth information of 3D video, music audio, dialog audio, and caption for children.", "In accordance with another aspect of the present invention, an apparatus for transmitting a broadcast signal includes a generator configured to generate service guide information including access information of a broadcast service and content data, wherein the service guide information includes a service fragment indicating information about the broadcast service, an encoder configured to encode the generated service guide information and content data, and a transmitter configured to transmit the encoded service guide information and content data.", "The service fragment may include service type information indicating type of the broadcast service, and the type of the broadcast service indicated by the service type information may include at least one of a linear service (Linear Service) that provides broadcast schedule information, an application based service (Appbased Service), and a companion screen service (CompanionScreen Service) using a companion device.", "In accordance with another aspect of the present invention, a method of receiving a broadcast signal includes receiving service guide information including access information of a broadcast service and content data, wherein the service guide information includes a service fragment indicating information about the broadcast service, and decoding the received service guide information and content data.", "The service fragment may include service type information indicating type of the broadcast service, and the type of the broadcast service indicated by the service type information may include at least one of a linear service (Linear Service) that provides broadcast schedule information, an application based service (Appbased Service), and a companion screen service (CompanionScreen Service) using a companion device.", "The service guide information may include a component fragment indicating information about a component included in the broadcast service, and the component fragment may include at least one of information that identifies the component fragment, component type information indicating type of the component, and component role information indicating role of the component.", "As is apparent from the above description, the embodiments of the present invention can process data according to service characteristics to control QoS (Quality of Service) for each service or service component, thereby providing various broadcast services.", "The embodiments of the present invention can achieve transmission flexibility by transmitting various broadcast services through the same radio frequency (RF) signal bandwidth.", "The embodiments of the present invention can improve data transmission efficiency and increase robustness of transmission/reception (Tx/Rx) of broadcast signals using a MIMO (Multiple Input Multiple Output) system.", "The embodiments of the present invention can provide a method and apparatus, which are configured to receive digital broadcast signals without errors even with mobile reception equipment or in an indoor environment, for transmitting and receiving broadcast signals.", "BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the invention and together with the description serve to explain the principle of the invention.", "In the drawings: FIG.", "1 illustrates a structure of an apparatus for transmitting broadcast signals for future broadcast services according to an embodiment of the present invention.", "FIG.", "2 illustrates an input formatting block according to one embodiment of the present invention.", "FIG.", "3 illustrates an input formatting block according to another embodiment of the present invention.", "FIG.", "4 illustrates a BICM block according to an embodiment of the present invention.", "FIG.", "5 illustrates a BICM block according to another embodiment of the present invention.", "FIG.", "6 illustrates a frame building block according to one embodiment of the present invention.", "FIG.", "7 illustrates an OFDM generation block according to an embodiment of the present invention.", "FIG.", "8 illustrates a structure of an apparatus for receiving broadcast signals for future broadcast services according to an embodiment of the present invention.", "FIG.", "9 illustrates a frame structure according to an embodiment of the present invention.", "FIG.", "10 illustrates a signaling hierarchy structure of the frame according to an embodiment of the present invention.", "FIG.", "11 illustrates preamble signaling data according to an embodiment of the present invention.", "FIG.", "12 illustrates PLS1 data according to an embodiment of the present invention.", "FIG.", "13 illustrates PLS2 data according to an embodiment of the present invention.", "FIG.", "14 illustrates PLS2 data according to another embodiment of the present invention.", "FIG.", "15 illustrates a logical structure of a frame according to an embodiment of the present invention.", "FIG.", "16 illustrates PLS mapping according to an embodiment of the present invention.", "FIG.", "17 illustrates EAC mapping according to an embodiment of the present invention.", "FIG.", "18 illustrates FIC mapping according to an embodiment of the present invention.", "FIG.", "19 illustrates an FEC structure according to an embodiment of the present invention.", "FIG.", "20 illustrates a time interleaving according to an embodiment of the present invention.", "FIG.", "21 illustrates the basic operation of a twisted row-column block interleaver according to an embodiment of the present invention.", "FIG.", "22 illustrates an operation of a twisted row-column block interleaver according to another embodiment of the present invention.", "FIG.", "23 illustrates a diagonal-wise reading pattern of a twisted row-column block interleaver according to an embodiment of the present invention.", "FIG.", "24 illustrates interleaved XFECBLOCKs from each interleaving array according to an embodiment of the present invention.", "FIG.", "25 is a block diagram illustrating a main physical device and a companion physical device according to an embodiment of the present invention.", "FIG.", "26 is a block diagram illustrating a protocol stack to support a hybrid broadcast service according to an embodiment of the present invention.", "FIG.", "27 is a conceptual diagram illustrating an XML schema of a Service Type element according to an embodiment of the present invention.", "FIG.", "28 illustrates an XML schema regarding a specific service having a service type value of 14, and an exemplary display image thereof according to an embodiment of the present invention.", "FIG.", "29 illustrates an XML schema regarding a specific service having service type values 14 and 15, and an exemplary display image thereof according to an embodiment of the present invention.", "FIG.", "30 illustrates an XML schema regarding a specific service having service type values 14 and 16, and an exemplary display image thereof according to an embodiment of the present invention.", "FIG.", "31 illustrates an XML schema of a Component Fragment according to an embodiment of the present invention.", "FIG.", "32 illustrates an XML schema of a ComponentType element according to an embodiment of the present invention.", "FIG.", "33 illustrates an XML schema of a ComponentData element according to an embodiment of the present invention.", "FIG.", "34 illustrates an XML schema of a VideoComponent element and a VideoRole element according to an embodiment of the present invention.", "FIG.", "35 illustrates an XML schema of an AudioComponent element and an AudioRole element according to an embodiment of the present invention.", "FIG.", "36 illustrates an XML schema of a CCComponent element and a CCRole element according to an embodiment of the present invention.", "FIG.", "37 illustrates an XML schema of component fragments regarding a Composite Video Component including one base layer and two enhancement layers in scalable video coding according to an embodiment of the present invention.", "FIG.", "38 illustrates an XML schema of component fragments regarding a Composite Component including a 3D video left view and a 3D video right view according to an embodiment of the present invention.", "FIG.", "39 illustrates an XML schema of component fragments configured to describe a Complete Audio Component according to an embodiment of the present invention.", "FIG.", "40 illustrates an XML schema of a component element contained in a content fragment according to an embodiment of the present invention.", "FIG.", "41 illustrates an XML schema of a content fragment regarding a Linear Service including Video, Audio, and CC Components according to an embodiment of the present invention.", "FIG.", "42 illustrates an XML schema of a component element when the component element is defined in the content fragment so as to describe the association relationship among Video, Audio, and CC components.", "FIG.", "43 is a conceptual diagram illustrating an exemplary case in which AssociatedTo attributes are used to describe the association relationship among Video, Audio, and CC components.", "FIG.", "44 is a conceptual diagram illustrating an exemplary case in which associatedAudio and associatedCC attributes are used to describe the association relationship among Video, Audio, and CC components.", "FIG.", "45 is a conceptual diagram illustrating the association relationship among Video, Audio, and CC components using AssociatedTo attributes.", "FIG.", "46 is a conceptual diagram illustrating the association relationship among Video, Audio, and CC components using associatedAudio and/or associatedCC attributes.", "FIG.", "47 is a conceptual diagram illustrating the reference relationship between fragments according to an embodiment of the present invention.", "FIG.", "48 illustrates an XML schema of a Component fragment including an element indicating the reference relationship between fragments according to an embodiment of the present invention.", "FIG.", "49 illustrates an XML schema of a Schedule fragment including an element indicating the reference relationship between fragments according to an embodiment of the present invention.", "FIG.", "50 illustrates the reference relationship among Service, Content, and Component fragments according to an embodiment of the present invention.", "FIG.", "51 illustrates the reference relationship among Component fragments configured to describe a Continuous Component according to an embodiment of the present invention.", "FIG.", "52 illustrates the reference relationship between Component fragments configured to describe a component associated with AppBased Enhancement according to an embodiment of the present invention.", "FIG.", "53 illustrates functions to be used when a content fragment refers to the associated service fragment according to an embodiment of the present invention.", "FIG.", "54 is a conceptual diagram illustrating an exemplary case in which the content fragment refers to the associated service fragment using the relationship attributes according to an embodiment of the present invention.", "FIG.", "55 is a conceptual diagram illustrating the reference relationship between fragments according to another embodiment of the present invention.", "FIG.", "56 is a conceptual diagram illustrating a service fragment including not only elements indicating the reference relationship between fragments, but also a content fragment and an XML schema of the component fragment according to another embodiment of the present invention.", "FIG.", "57 is a conceptual diagram illustrating the reference relationship between Service, Content and Component fragments according to another embodiment of the present invention.", "FIG.", "58 is a conceptual diagram illustrating the reference relationship between Component fragments describing a Continuous Component according to another embodiment of the present invention.", "FIG.", "59 is a conceptual diagram illustrating the reference relationship between Component fragments describing a component associated with AppBased Enhancement according to another embodiment of the present invention.", "FIGS.", "60 and 61 illustrate the Component fragments according to an embodiment of the present invention.", "FIG.", "62 illustrates an XML schema of a Component fragment according to another embodiment of the present invention.", "FIG.", "63 illustrates an XML schema of a ComponentType element according to another embodiment of the present invention.", "FIG.", "64 illustrates an XML schema of a ComponentRole element according to an embodiment of the present invention.", "FIG.", "65 illustrates an XML schema of component fragments regarding a Composite Video Component including one base layer and two enhancement layers in scalable video coding according to another embodiment of the present invention.", "FIG.", "66 illustrates an XML schema of component fragments regarding a Composite Component including a 3D video left view and a 3D video right view according to an embodiment of the present invention.", "FIG.", "67 illustrates an XML schema of component fragments configured to describe a Complete Audio Component according to another embodiment of the present invention.", "FIG.", "68 is a structural view illustrating a Content fragment according to an embodiment of the present invention.", "FIGS.", "69, 70, 71, and 72 are structural views illustrating Component elements according to an embodiment of the present invention.", "FIG.", "73 illustrates an XML schema of a Component element according to an embodiment of the present invention.", "FIG.", "74 illustrates an XML schema of a Language element and a ComponentType element according to an embodiment of the present invention.", "FIG.", "75 illustrates an XML schema of a ComponentRole element according to an embodiment of the present invention.", "FIG.", "76 illustrates an XML schema of a DeviceCapability element and a TargetDevice element according to an embodiment of the present invention.", "FIG.", "77 illustrates an XML schema of a Component element when a Presentable Video Component (2D/HD) and a Presentable Audio Component (5.1 channels) are transmitted.", "FIG.", "78 illustrates an XML schema of a Component element when a Presentable Video component (UHD) and Presentable ENG audio component are transmitted as broadcast signals and a Presentable SPA audio component is transmitted as a broadband signal.", "FIG.", "79 illustrates an XML schema of a Component element when a Presentable Video Component (UHD/Wide Color Gamut) and a Presentable Audio Component (5.1 channels) are transmitted.", "FIG.", "80 illustrates a component element according to another embodiment of the present invention.", "FIG.", "81 illustrates a ComponentRole element according to an embodiment of the present invention.", "FIG.", "82 illustrates an XML-formatted component element according to another embodiment of the present invention.", "FIG.", "83 is a conceptual diagram illustrating a Component element according to another embodiment of the present invention.", "FIG.", "84 illustrates a PresentableCCComponent element and a PresentableAppComponent element according to another embodiment of the present invention.", "FIG.", "85 illustrates an XML-formatted component element according to another embodiment of the present invention.", "FIG.", "86 illustrates Essential Capabilities elements according to an embodiment of the present invention.", "FIG.", "87 illustrates the meaning of Capability in response to a CapabilityCode element value according to an embodiment of the present invention.", "FIG.", "88 illustrates a Capability Category dependent upon a Category attribute information value.", "FIG.", "89 is a conceptual diagram illustrating a method for providing a PPV (Pay Per View) program to each component according to an embodiment of the present invention.", "FIG.", "90 is a flowchart illustrating a method for providing media to each component of a broadcast program according to an embodiment of the present invention.", "FIG.", "91 exemplarily illustrates screen images through which media is supplied to each component of a broadcast program according to an embodiment of the present invention.", "FIG.", "92 exemplarily illustrates screen images through which the role of a video component is displayed on ESG according to an embodiment of the present invention.", "FIG.", "93 exemplarily illustrates screen images through which the role of a video component is displayed on ESG according to another embodiment of the present invention.", "FIG.", "94 exemplarily illustrates screen images through which the role of a video component is displayed on ESG according to another embodiment of the present invention.", "FIG.", "95 exemplarily illustrates screen images through which the role of an audio component is displayed on ESG according to an embodiment of the present invention.", "FIG.", "96 exemplarily illustrates screen images through which the role of an audio component is displayed on ESG according to another embodiment of the present invention.", "FIG.", "97 exemplarily illustrates screen images through which the role of an audio component is displayed on ESG according to another embodiment of the present invention.", "FIG.", "98 illustrates an exemplary case in which the role of a Closed Caption (CC) component is displayed on ESG according to an embodiment of the present invention.", "FIG.", "99 is a diagram illustrating a broadcast signal transmission method according to an embodiment of the present invention.", "FIG.", "100 is a diagram illustrating a broadcast signal reception apparatus according to an embodiment of the present invention.", "FIG.", "101 is a diagram illustrating a broadcast signal transmission apparatus according to an embodiment of the present invention.", "FIG.", "102 is a diagram illustrating a broadcast signal reception method according to an embodiment of the present invention.", "DETAILED DESCRIPTION OF THE EMBODIMENTS Reference will now be made in detail to the preferred embodiments of the present invention, examples of which are illustrated in the accompanying drawings.", "The detailed description, which will be given below with reference to the accompanying drawings, is intended to explain exemplary embodiments of the present invention, rather than to show the only embodiments that can be implemented according to the present invention.", "Although most terms of elements in this specification have been selected from general ones widely used in the art taking into consideration functions thereof in this specification, the terms may be changed depending on the intention or convention of those skilled in the art or the introduction of new technology.", "Some terms have been arbitrarily selected by the applicant and their meanings are explained in the following description as needed.", "Thus, the terms used in this specification should be construed based on the overall content of this specification together with the actual meanings of the terms rather than their simple names or meanings.", "The term “signaling” in the present invention may indicate that service information (SI) that is transmitted and received from a broadcast system, an Internet system, and/or a broadcast/Internet convergence system.", "The service information (SI) may include broadcast service information (e.g., ATSC-SI and/or DVB-SI) received from the existing broadcast systems.", "The term “broadcast signal” may conceptually include not only signals and/or data received from a terrestrial broadcast, a cable broadcast, a satellite broadcast, and/or a mobile broadcast, but also signals and/or data received from bidirectional broadcast systems such as an Internet broadcast, a broadband broadcast, a communication broadcast, a data broadcast, and/or VOD (Video On Demand).", "The term “PLP” may indicate a predetermined unit for transmitting data contained in a physical layer.", "Therefore, the term “PLP” may also be replaced with the terms ‘data unit’ or ‘data pipe’ as necessary.", "A hybrid broadcast service configured to interwork with the broadcast network and/or the Internet network may be used as a representative application to be used in a digital television (DTV) service.", "The hybrid broadcast service transmits, in real time, enhancement data related to broadcast A/V (Audio/Video) contents transmitted through the terrestrial broadcast network over the Internet, or transmits, in real time, some parts of the broadcast A/V contents over the Internet, such that users can experience a variety of contents.", "The present invention provides apparatuses and methods for transmitting and receiving broadcast signals for future broadcast services.", "Future broadcast services according to an embodiment of the present invention include a terrestrial broadcast service, a mobile broadcast service, a UHDTV service, etc.", "The present invention may process broadcast signals for the future broadcast services through non-MIMO (Multiple Input Multiple Output) or MIMO according to one embodiment.", "A non-MIMO scheme according to an embodiment of the present invention may include a MISO (Multiple Input Single Output) scheme, a SISO (Single Input Single Output) scheme, etc.", "While MISO or MIMO uses two antennas in the following for convenience of description, the present invention is applicable to systems using two or more antennas.", "The present invention may defines three physical layer (PL) profiles—base, handheld and advanced profiles—each optimized to minimize receiver complexity while attaining the performance required for a particular use case.", "The physical layer (PHY) profiles are subsets of all configurations that a corresponding receiver should implement.", "The three PHY profiles share most of the functional blocks but differ slightly in specific blocks and/or parameters.", "Additional PHY profiles can be defined in the future.", "For the system evolution, future profiles can also be multiplexed with the existing profiles in a single RF channel through a future extension frame (FEF).", "The details of each PHY profile are described below.", "1.Base Profile The base profile represents a main use case for fixed receiving devices that are usually connected to a roof-top antenna.", "The base profile also includes portable devices that could be transported to a place but belong to a relatively stationary reception category.", "Use of the base profile could be extended to handheld devices or even vehicular by some improved implementations, but those use cases are not expected for the base profile receiver operation.", "Target SNR range of reception is from approximately 10 to 20 dB, which includes the 15 dB SNR reception capability of the existing broadcast system (e.g.", "ATSC A/53).", "The receiver complexity and power consumption is not as critical as in the battery-operated handheld devices, which will use the handheld profile.", "Key system parameters for the base profile are listed in below table 1.TABLE 1 LDPC codeword length 16K, 64K bits Constellation size 4~10 bpcu (bits per channel use) Time de-interleaving memory size ≤219 data cells Pilot patterns Pilot pattern for fixed reception FFT size 16K, 32K points 2.Handheld Profile The handheld profile is designed for use in handheld and vehicular devices that operate with battery power.", "The devices can be moving with pedestrian or vehicle speed.", "The power consumption as well as the receiver complexity is very important for the implementation of the devices of the handheld profile.", "The target SNR range of the handheld profile is approximately 0 to 10 dB, but can be configured to reach below 0 dB when intended for deeper indoor reception.", "In addition to low SNR capability, resilience to the Doppler Effect caused by receiver mobility is the most important performance attribute of the handheld profile.", "Key system parameters for the handheld profile are listed in the below table 2.TABLE 2 LDPC codeword length 16K bits Constellation size 2~8 bpcu Time de-interleaving memory size ≤218 data cells Pilot patterns Pilot patterns for mobile and indoor reception FFT size 8K, 16K points 3.Advanced Profile The advanced profile provides highest channel capacity at the cost of more implementation complexity.", "This profile requires using MIMO transmission and reception, and UHDTV service is a target use case for which this profile is specifically designed.", "The increased capacity can also be used to allow an increased number of services in a given bandwidth, e.g., multiple SDTV or HDTV services.", "The target SNR range of the advanced profile is approximately 20 to 30 dB.", "MIMO transmission may initially use existing elliptically-polarized transmission equipment, with extension to full-power cross-polarized transmission in the future.", "Key system parameters for the advanced profile are listed in below table 3.TABLE 3 LDPC codeword length 16K, 64K bits Constellation size 8~12 bpcu Time de-interleaving memory size ≤219 data cells Pilot patterns Pilot pattern for fixed reception FFT size 16K, 32K points In this case, the base profile can be used as a profile for both the terrestrial broadcast service and the mobile broadcast service.", "That is, the base profile can be used to define a concept of a profile which includes the mobile profile.", "Also, the advanced profile can be divided advanced profile for a base profile with MIMO and advanced profile for a handheld profile with MIMO.", "Moreover, the three profiles can be changed according to intention of the designer.", "The following terms and definitions may apply to the present invention.", "The following terms and definitions can be changed according to design.", "auxiliary stream: sequence of cells carrying data of as yet undefined modulation and coding, which may be used for future extensions or as required by broadcasters or network operators.", "base data pipe: data pipe that carries service signaling data.", "baseband frame (or BBFRAME): set of Kbch bits which form the input to one FEC encoding process (BCH and LDPC encoding).", "cell: modulation value that is carried by one carrier of the OFDM transmission.", "coded block: LDPC-encoded block of PLS1 data or one of the LDPC-encoded blocks of PLS2 data.", "data pipe: logical channel in the physical layer that carries service data or related metadata, which may carry one or multiple service(s) or service component(s).", "data pipe unit: a basic unit for allocating data cells to a DP in a frame.", "data symbol: OFDM symbol in a frame which is not a preamble symbol (the frame signaling symbol and frame edge symbol is included in the data symbol).", "DP_ID: this 8-bit field identifies uniquely a DP within the system identified by the SYSTEM_ID.", "dummy cell: cell carrying a pseudo-random value used to fill the remaining capacity not used for PLS signaling, DPs or auxiliary streams.", "emergency alert channel: part of a frame that carries EAS information data.", "frame: physical layer time slot that starts with a preamble and ends with a frame edge symbol.", "frame repetition unit: a set of frames belonging to same or different physical layer profile including a FEF, which is repeated eight times in a super-frame.", "fast information channel: a logical channel in a frame that carries the mapping information between a service and the corresponding base DP.", "FECBLOCK: set of LDPC-encoded bits of a DP data.", "FFT size: nominal FFT size used for a particular mode, equal to the active symbol period Ts expressed in cycles of the elementary period T. frame signaling symbol: OFDM symbol with higher pilot density used at the start of a frame in certain combinations of FFT size, guard interval and scattered pilot pattern, which carries a part of the PLS data.", "frame edge symbol: OFDM symbol with higher pilot density used at the end of a frame in certain combinations of FFT size, guard interval and scattered pilot pattern.", "frame-group: the set of all the frames having the same PHY profile type in a super-frame.", "future extension frame: physical layer time slot within the super-frame that could be used for future extension, which starts with a preamble.", "Futurecast UTB system: proposed physical layer broadcasting system, of which the input is one or more MPEG2-TS or IP or general stream(s) and of which the output is an RF signal.", "input stream: A stream of data for an ensemble of services delivered to the end users by the system.", "normal data symbol: data symbol excluding the frame signaling symbol and the frame edge symbol.", "PHY profile: subset of all configurations that a corresponding receiver should implement.", "PLS: physical layer signaling data consisting of PLS1 and PLS2.PLS1: a first set of PLS data carried in the FSS symbols having a fixed size, coding and modulation, which carries basic information about the system as well as the parameters needed to decode the PLS2.NOTE: PLS1 data remains constant for the duration of a frame-group.", "PLS2: a second set of PLS data transmitted in the FSS symbol, which carries more detailed PLS data about the system and the DPs.", "PLS2 dynamic data: PLS2 data that may dynamically change frame-by-frame.", "PLS2 static data: PLS2 data that remains static for the duration of a frame-group.", "preamble signaling data: signaling data carried by the preamble symbol and used to identify the basic mode of the system.", "preamble symbol: fixed-length pilot symbol that carries basic PLS data and is located in the beginning of a frame.", "NOTE: The preamble symbol is mainly used for fast initial band scan to detect the system signal, its timing, frequency offset, and FFT-size.", "reserved for future use: not defined by the present document but may be defined in future.", "super-frame: set of eight frame repetition units.", "time interleaving block (TI block): set of cells within which time interleaving is carried out, corresponding to one use of the time interleaver memory.", "TI group: unit over which dynamic capacity allocation for a particular DP is carried out, made up of an integer, dynamically varying number of XFECBLOCKs.", "NOTE: The TI group may be mapped directly to one frame or may be mapped to multiple frames.", "It may contain one or more TI blocks.", "Type 1 DP: DP of a frame where all DPs are mapped into the frame in TDM fashion.", "Type 2 DP: DP of a frame where all DPs are mapped into the frame in FDM fashion.", "XFECBLOCK: set of Ncells cells carrying all the bits of one LDPC FECBLOCK.", "FIG.", "1 illustrates a structure of an apparatus for transmitting broadcast signals for future broadcast services according to an embodiment of the present invention.", "The apparatus for transmitting broadcast signals for future broadcast services according to an embodiment of the present invention can include an input formatting block 1000, a BICM (Bit interleaved coding & modulation) block 1010, a frame building block 1020, an OFDM (Orthogonal Frequency Division Multiplexing) generation block 1030 and a signaling generation block 1040.A description will be given of the operation of each module of the apparatus for transmitting broadcast signals.", "IP stream/packets and MPEG2-TS are the main input formats, other stream types are handled as General Streams.", "In addition to these data inputs, Management Information is input to control the scheduling and allocation of the corresponding bandwidth for each input stream.", "One or multiple TS stream(s), IP stream(s) and/or General Stream(s) inputs are simultaneously allowed.", "The input formatting block 1000 can demultiplex each input stream into one or multiple data pipe(s), to each of which an independent coding and modulation is applied.", "The data pipe (DP) is the basic unit for robustness control, thereby affecting quality-of-service (QoS).", "One or multiple service(s) or service component(s) can be carried by a single DP.", "Details of operations of the input formatting block 1000 will be described later.", "The data pipe is a logical channel in the physical layer that carries service data or related metadata, which may carry one or multiple service(s) or service component(s).", "Also, the data pipe unit: a basic unit for allocating data cells to a DP in a frame.", "In the BICM block 1010, parity data is added for error correction and the encoded bit streams are mapped to complex-value constellation symbols.", "The symbols are interleaved across a specific interleaving depth that is used for the corresponding DP.", "For the advanced profile, MIMO encoding is performed in the BICM block 1010 and the additional data path is added at the output for MIMO transmission.", "Details of operations of the BICM block 1010 will be described later.", "The Frame Building block 1020 can map the data cells of the input DPs into the OFDM symbols within a frame.", "After mapping, the frequency interleaving is used for frequency-domain diversity, especially to combat frequency-selective fading channels.", "Details of operations of the Frame Building block 1020 will be described later.", "After inserting a preamble at the beginning of each frame, the OFDM Generation block 1030 can apply conventional OFDM modulation having a cyclic prefix as guard interval.", "For antenna space diversity, a distributed MISO scheme is applied across the transmitters.", "In addition, a Peak-to-Average Power Reduction (PAPR) scheme is performed in the time domain.", "For flexible network planning, this proposal provides a set of various FFT sizes, guard interval lengths and corresponding pilot patterns.", "Details of operations of the OFDM Generation block 1030 will be described later.", "The Signaling Generation block 1040 can create physical layer signaling information used for the operation of each functional block.", "This signaling information is also transmitted so that the services of interest are properly recovered at the receiver side.", "Details of operations of the Signaling Generation block 1040 will be described later.", "FIGS.", "2, 3 and 4 illustrate the input formatting block 1000 according to embodiments of the present invention.", "A description will be given of each figure.", "FIG.", "2 illustrates an input formatting block according to one embodiment of the present invention.", "FIG.", "2 shows an input formatting module when the input signal is a single input stream.", "The input formatting block illustrated in FIG.", "2 corresponds to an embodiment of the input formatting block 1000 described with reference to FIG.", "1.The input to the physical layer may be composed of one or multiple data streams.", "Each data stream is carried by one DP.", "The mode adaptation modules slice the incoming data stream into data fields of the baseband frame (BBF).", "The system supports three types of input data streams: MPEG2-TS, Internet protocol (IP) and Generic stream (GS).", "MPEG2-TS is characterized by fixed length (188 byte) packets with the first byte being a sync-byte (0x47).", "An IP stream is composed of variable length IP datagram packets, as signaled within IP packet headers.", "The system supports both IPv4 and IPv6 for the IP stream.", "GS may be composed of variable length packets or constant length packets, signaled within encapsulation packet headers.", "(a) shows a mode adaptation block 2000 and a stream adaptation 2010 for signal DP and (b) shows a PLS generation block 2020 and a PLS scrambler 2030 for generating and processing PLS data.", "A description will be given of the operation of each block.", "The Input Stream Splitter splits the input TS, IP, GS streams into multiple service or service component (audio, video, etc.)", "streams.", "The mode adaptation module 2010 is comprised of a CRC Encoder, BB (baseband) Frame Slicer, and BB Frame Header Insertion block.", "The CRC Encoder provides three kinds of CRC encoding for error detection at the user packet (UP) level, i.e., CRC-8, CRC-16, and CRC-32.The computed CRC bytes are appended after the UP.", "CRC-8 is used for TS stream and CRC-32 for IP stream.", "If the GS stream doesn't provide the CRC encoding, the proposed CRC encoding should be applied.", "BB Frame Slicer maps the input into an internal logical-bit format.", "The first received bit is defined to be the MSB.", "The BB Frame Slicer allocates a number of input bits equal to the available data field capacity.", "To allocate a number of input bits equal to the BBF payload, the UP packet stream is sliced to fit the data field of BBF.", "BB Frame Header Insertion block can insert fixed length BBF header of 2 bytes is inserted in front of the BB Frame.", "The BBF header is composed of STUFFI (1 bit), SYNCD (13 bits), and RFU (2 bits).", "In addition to the fixed 2-Byte BBF header, BBF can have an extension field (1 or 3 bytes) at the end of the 2-byte BBF header.", "The stream adaptation 2010 is comprised of stuffing insertion block and BB scrambler.", "The stuffing insertion block can insert stuffing field into a payload of a BB frame.", "If the input data to the stream adaptation is sufficient to fill a BB-Frame, STUFFI is set to ‘0’ and the BBF has no stuffing field.", "Otherwise STUFFI is set to ‘1’ and the stuffing field is inserted immediately after the BBF header.", "The stuffing field comprises two bytes of the stuffing field header and a variable size of stuffing data.", "The BB scrambler scrambles complete BBF for energy dispersal.", "The scrambling sequence is synchronous with the BBF.", "The scrambling sequence is generated by the feed-back shift register.", "The PLS generation block 2020 can generate physical layer signaling (PLS) data.", "The PLS provides the receiver with a means to access physical layer DPs.", "The PLS data consists of PLS1 data and PLS2 data.", "The PLS1 data is a first set of PLS data carried in the FSS symbols in the frame having a fixed size, coding and modulation, which carries basic information about the system as well as the parameters needed to decode the PLS2 data.", "The PLS1 data provides basic transmission parameters including parameters required to enable the reception and decoding of the PLS2 data.", "Also, the PLS1 data remains constant for the duration of a frame-group.", "The PLS2 data is a second set of PLS data transmitted in the FSS symbol, which carries more detailed PLS data about the system and the DPs.", "The PLS2 contains parameters that provide sufficient information for the receiver to decode the desired DP.", "The PLS2 signaling further consists of two types of parameters, PLS2 Static data (PLS2-STAT data) and PLS2 dynamic data (PLS2-DYN data).", "The PLS2 Static data is PLS2 data that remains static for the duration of a frame-group and the PLS2 dynamic data is PLS2 data that may dynamically change frame-by-frame.", "Details of the PLS data will be described later.", "The PLS scrambler 2030 can scramble the generated PLS data for energy dispersal.", "The above-described blocks may be omitted or replaced by blocks having similar or identical functions.", "FIG.", "3 illustrates an input formatting block according to another embodiment of the present invention.", "The input formatting block illustrated in FIG.", "3 corresponds to an embodiment of the input formatting block 1000 described with reference to FIG.", "1.FIG.", "3 shows a mode adaptation block of the input formatting block when the input signal corresponds to multiple input streams.", "The mode adaptation block of the input formatting block for processing the multiple input streams can independently process the multiple input streams.", "Referring to FIG.", "3, the mode adaptation block for respectively processing the multiple input streams can include an input stream splitter 3000, an input stream synchronizer 3010, a compensating delay block 3020, a null packet deletion block 3030, a head compression block 3040, a CRC encoder 3050, a BB frame slicer 3060 and a BB header insertion block 3070.Description will be given of each block of the mode adaptation block.", "Operations of the CRC encoder 3050, BB frame slicer 3060 and BB header insertion block 3070 correspond to those of the CRC encoder, BB frame slicer and BB header insertion block described with reference to FIG.", "2 and thus description thereof is omitted.", "The input stream splitter 3000 can split the input TS, IP, GS streams into multiple service or service component (audio, video, etc.)", "streams.", "The input stream synchronizer 3010 may be referred as ISSY.", "The ISSY can provide suitable means to guarantee Constant Bit Rate (CBR) and constant end-to-end transmission delay for any input data format.", "The ISSY is always used for the case of multiple DPs carrying TS, and optionally used for multiple DPs carrying GS streams.", "The compensating delay block 3020 can delay the split TS packet stream following the insertion of ISSY information to allow a TS packet recombining mechanism without requiring additional memory in the receiver.", "The null packet deletion block 3030, is used only for the TS input stream case.", "Some TS input streams or split TS streams may have a large number of null-packets present in order to accommodate VBR (variable bit-rate) services in a CBR TS stream.", "In this case, in order to avoid unnecessary transmission overhead, null-packets can be identified and not transmitted.", "In the receiver, removed null-packets can be re-inserted in the exact place where they were originally by reference to a deleted null-packet (DNP) counter that is inserted in the transmission, thus guaranteeing constant bit-rate and avoiding the need for time-stamp (PCR) updating.", "The head compression block 3040 can provide packet header compression to increase transmission efficiency for TS or IP input streams.", "Because the receiver can have a priori information on certain parts of the header, this known information can be deleted in the transmitter.", "For Transport Stream, the receiver has a-priori information about the sync-byte configuration (0x47) and the packet length (188 Byte).", "If the input TS stream carries content that has only one PID, i.e., for only one service component (video, audio, etc.)", "or service sub-component (SVC base layer, SVC enhancement layer, MVC base view or MVC dependent views), TS packet header compression can be applied (optionally) to the Transport Stream.", "IP packet header compression is used optionally if the input steam is an IP stream.", "The above-described blocks may be omitted or replaced by blocks having similar or identical functions.", "FIG.", "4 illustrates a BICM block according to an embodiment of the present invention.", "The BICM block illustrated in FIG.", "4 corresponds to an embodiment of the BICM block 1010 described with reference to FIG.", "1.As described above, the apparatus for transmitting broadcast signals for future broadcast services according to an embodiment of the present invention can provide a terrestrial broadcast service, mobile broadcast service, UHDTV service, etc.", "Since QoS (quality of service) depends on characteristics of a service provided by the apparatus for transmitting broadcast signals for future broadcast services according to an embodiment of the present invention, data corresponding to respective services needs to be processed through different schemes.", "Accordingly, the a BICM block according to an embodiment of the present invention can independently process DPs input thereto by independently applying SISO, MISO and MIMO schemes to the data pipes respectively corresponding to data paths.", "Consequently, the apparatus for transmitting broadcast signals for future broadcast services according to an embodiment of the present invention can control QoS for each service or service component transmitted through each DP.", "(a) shows the BICM block shared by the base profile and the handheld profile and (b) shows the BICM block of the advanced profile.", "The BICM block shared by the base profile and the handheld profile and the BICM block of the advanced profile can include plural processing blocks for processing each DP.", "A description will be given of each processing block of the BICM block for the base profile and the handheld profile and the BICM block for the advanced profile.", "A processing block 5000 of the BICM block for the base profile and the handheld profile can include a Data FEC encoder 5010, a bit interleaver 5020, a constellation mapper 5030, an SSD (Signal Space Diversity) encoding block 5040 and a time interleaver 5050.The Data FEC encoder 5010 can perform the FEC encoding on the input BBF to generate FECBLOCK procedure using outer coding (BCH), and inner coding (LDPC).", "The outer coding (BCH) is optional coding method.", "Details of operations of the Data FEC encoder 5010 will be described later.", "The bit interleaver 5020 can interleave outputs of the Data FEC encoder 5010 to achieve optimized performance with combination of the LDPC codes and modulation scheme while providing an efficiently implementable structure.", "Details of operations of the bit interleaver 5020 will be described later.", "The constellation mapper 5030 can modulate each cell word from the bit interleaver 5020 in the base and the handheld profiles, or cell word from the Cell-word demultiplexer 5010-1 in the advanced profile using either QPSK, QAM-16, non-uniform QAM (NUQ-64, NUQ-256, NUQ-1024) or non-uniform constellation (NUC-16, NUC-64, NUC-256, NUC-1024) to give a power-normalized constellation point, el.", "This constellation mapping is applied only for DPs.", "Observe that QAM-16 and NUQs are square shaped, while NUCs have arbitrary shape.", "When each constellation is rotated by any multiple of 90 degrees, the rotated constellation exactly overlaps with its original one.", "This “rotation-sense” symmetric property makes the capacities and the average powers of the real and imaginary components equal to each other.", "Both NUQs and NUCs are defined specifically for each code rate and the particular one used is signaled by the parameter DP_MOD filed in PLS2 data.", "The time interleaver 5050 can operates at the DP level.", "The parameters of time interleaving (TI) may be set differently for each DP.", "Details of operations of the time interleaver 5050 will be described later.", "A processing block 50001 of the BICM block for the advanced profile can include the Data FEC encoder, bit interleaver, constellation mapper, and time interleaver.", "However, the processing block 5000-1 is distinguished from the processing block 5000 further includes a cell-word demultiplexer 50101 and a MIMO encoding block 50201.Also, the operations of the Data FEC encoder, bit interleaver, constellation mapper, and time interleaver in the processing block 5000-1 correspond to those of the Data FEC encoder 5010, bit interleaver 5020, constellation mapper 5030, and time interleaver 5050 described and thus description thereof is omitted.", "The cell-word demultiplexer 5010-1 is used for the DP of the advanced profile to divide the single cell-word stream into dual cell-word streams for MIMO processing.", "Details of operations of the cell-word demultiplexer 5010-1 will be described later.", "The MIMO encoding block 5020-1 can processing the output of the cell-word demultiplexer 5010-1 using MIMO encoding scheme.", "The MIMO encoding scheme was optimized for broadcasting signal transmission.", "The MIMO technology is a promising way to get a capacity increase but it depends on channel characteristics.", "Especially for broadcasting, the strong LOS component of the channel or a difference in the received signal power between two antennas caused by different signal propagation characteristics makes it difficult to get capacity gain from MIMO.", "The proposed MIMO encoding scheme overcomes this problem using a rotation-based pre-coding and phase randomization of one of the MIMO output signals.", "MIMO encoding is intended for a 2×2 MIMO system requiring at least two antennas at both the transmitter and the receiver.", "Two MIMO encoding modes are defined in this proposal; full-rate spatial multiplexing (FR-SM) and full-rate full-diversity spatial multiplexing (FRFD-SM).", "The FR-SM encoding provides capacity increase with relatively small complexity increase at the receiver side while the FRFD-SM encoding provides capacity increase and additional diversity gain with a great complexity increase at the receiver side.", "The proposed MIMO encoding scheme has no restriction on the antenna polarity configuration.", "MIMO processing is required for the advanced profile frame, which means all DPs in the advanced profile frame are processed by the MIMO encoder.", "MIMO processing is applied at DP level.", "Pairs of the Constellation Mapper outputs NUQ (e1,i and e2,i) are fed to the input of the MIMO Encoder.", "Paired MIMO Encoder output (g1,i and g2,i) is transmitted by the same carrier k and OFDM symbol 1 of their respective TX antennas.", "The above-described blocks may be omitted or replaced by blocks having similar or identical functions.", "FIG.", "5 illustrates a BICM block according to another embodiment of the present invention.", "The BICM block illustrated in FIG.", "6 corresponds to an embodiment of the BICM block 1010 described with reference to FIG.", "1.FIG.", "5 illustrates a BICM block for protection of physical layer signaling (PLS), emergency alert channel (EAC) and fast information channel (FIC).", "EAC is a part of a frame that carries EAS information data and FIC is a logical channel in a frame that carries the mapping information between a service and the corresponding base DP.", "Details of the EAC and FIC will be described later.", "Referring to FIG.", "6, the BICM block for protection of PLS, EAC and FIC can include a PLS FEC encoder 6000, a bit interleaver 6010 and a constellation mapper 6020.Also, the PLS FEC encoder 6000 can include a scrambler, BCH encoding/zero insertion block, LDPC encoding block and LDPC parity puncturing block.", "Description will be given of each block of the BICM block.", "The PLS FEC encoder 6000 can encode the scrambled PLS 1/2 data, EAC and FIC section.", "The scrambler can scramble PLS1 data and PLS2 data before BCH encoding and shortened and punctured LDPC encoding.", "The BCH encoding/zero insertion block can perform outer encoding on the scrambled PLS 1/2 data using the shortened BCH code for PLS protection and insert zero bits after the BCH encoding.", "For PLS1 data only, the output bits of the zero insertion may be permuted before LDPC encoding.", "The LDPC encoding block can encode the output of the BCH encoding/zero insertion block using LDPC code.", "To generate a complete coded block, Cldpc, parity bits, Pldpc are encoded systematically from each zero-inserted PLS information block, Ildpc and appended after it.", "Cldpc=[IldpcPldpc]=[i0,i1, .", ".", ".", ",iKldpc−1,P0,P1, .", ".", ".", ",PNldpc−Kldpc−1] [Equation 1] The LDPC code parameters for PLS1 and PLS2 are as following table 4.TABLE 4 Signaling Kldpc code Type Ksig Kbch Nbch—parity (=Nbch) Nldpc Nldpc—parity rate Qldpc PLS1 342 1020 60 1080 4320 3240 1/4 36 PLS2 <1021 >1020 2100 2160 7200 5040 3/10 56 The LDPC parity puncturing block can perform puncturing on the PLS1 data and PLS 2 data.", "When shortening is applied to the PLS1 data protection, some LDPC parity bits are punctured after LDPC encoding.", "Also, for the PLS2 data protection, the LDPC parity bits of PLS2 are punctured after LDPC encoding.", "These punctured bits are not transmitted.", "The bit interleaver 6010 can interleave the each shortened and punctured PLS1 data and PLS2 data.", "The constellation mapper 6020 can map the bit interleaved PLS1 data and PLS2 data onto constellations.", "The above-described blocks may be omitted or replaced by blocks having similar or identical functions.", "FIG.", "6 illustrates a frame building block according to one embodiment of the present invention.", "The frame building block illustrated in FIG.", "6 corresponds to an embodiment of the frame building block 1020 described with reference to FIG.", "1.Referring to FIG.", "6, the frame building block can include a delay compensation block 7000, a cell mapper 7010 and a frequency interleaver 7020.Description will be given of each block of the frame building block.", "The delay compensation block 7000 can adjust the timing between the data pipes and the corresponding PLS data to ensure that they are co-timed at the transmitter end.", "The PLS data is delayed by the same amount as data pipes are by addressing the delays of data pipes caused by the Input Formatting block and BICM block.", "The delay of the BICM block is mainly due to the time interleaver 5050.In-band signaling data carries information of the next TI group so that they are carried one frame ahead of the DPs to be signaled.", "The Delay Compensating block delays in-band signaling data accordingly.", "The cell mapper 7010 can map PLS, EAC, FIC, DPs, auxiliary streams and dummy cells into the active carriers of the OFDM symbols in the frame.", "The basic function of the cell mapper 7010 is to map data cells produced by the TIs for each of the DPs, PLS cells, and EAC/FIC cells, if any, into arrays of active OFDM cells corresponding to each of the OFDM symbols within a frame.", "Service signaling data (such as PSI (program specific information)/SI) can be separately gathered and sent by a data pipe.", "The Cell Mapper operates according to the dynamic information produced by the scheduler and the configuration of the frame structure.", "Details of the frame will be described later.", "The frequency interleaver 7020 can randomly interleave data cells received from the cell mapper 7010 to provide frequency diversity.", "Also, the frequency interleaver 7020 can operate on very OFDM symbol pair comprised of two sequential OFDM symbols using a different interleaving-seed order to get maximum interleaving gain in a single frame.", "The above-described blocks may be omitted or replaced by blocks having similar or identical functions.", "FIG.", "7 illustrates an OFDM generation block according to an embodiment of the present invention.", "The OFDM generation block illustrated in FIG.", "7 corresponds to an embodiment of the OFDM generation block 1030 described with reference to FIG.", "1.The OFDM generation block modulates the OFDM carriers by the cells produced by the Frame Building block, inserts the pilots, and produces the time domain signal for transmission.", "Also, this block subsequently inserts guard intervals, and applies PAPR (Peak-to-Average Power Radio) reduction processing to produce the final RF signal.", "Referring to FIG.", "7, the OFDM generation block can include a pilot and reserved tone insertion block 8000, a 2D-eSFN encoding block 8010, an IFFT (Inverse Fast Fourier Transform) block 8020, a PAPR reduction block 8030, a guard interval insertion block 8040, a preamble insertion block 8050, other system insertion block 8060 and a DAC block 8070.The other system insertion block 8060 can multiplex signals of a plurality of broadcast transmission/reception systems in the time domain such that data of two or more different broadcast transmission/reception systems providing broadcast services can be simultaneously transmitted in the same RF signal bandwidth.", "In this case, the two or more different broadcast transmission/reception systems refer to systems providing different broadcast services.", "The different broadcast services may refer to a terrestrial broadcast service, mobile broadcast service, etc.", "FIG.", "8 illustrates a structure of an apparatus for receiving broadcast signals for future broadcast services according to an embodiment of the present invention.", "The apparatus for receiving broadcast signals for future broadcast services according to an embodiment of the present invention can correspond to the apparatus for transmitting broadcast signals for future broadcast services, described with reference to FIG.", "1.The apparatus for receiving broadcast signals for future broadcast services according to an embodiment of the present invention can include a synchronization & demodulation module 9000, a frame parsing module 9010, a demapping & decoding module 9020, an output processor 9030 and a signaling decoding module 9040.A description will be given of operation of each module of the apparatus for receiving broadcast signals.", "The synchronization & demodulation module 9000 can receive input signals through m Rx antennas, perform signal detection and synchronization with respect to a system corresponding to the apparatus for receiving broadcast signals and carry out demodulation corresponding to a reverse procedure of the procedure performed by the apparatus for transmitting broadcast signals.", "The frame parsing module 9010 can parse input signal frames and extract data through which a service selected by a user is transmitted.", "If the apparatus for transmitting broadcast signals performs interleaving, the frame parsing module 9010 can carry out deinterleaving corresponding to a reverse procedure of interleaving.", "In this case, the positions of a signal and data that need to be extracted can be obtained by decoding data output from the signaling decoding module 9040 to restore scheduling information generated by the apparatus for transmitting broadcast signals.", "The demapping & decoding module 9020 can convert the input signals into bit domain data and then deinterleave the same as necessary.", "The demapping & decoding module 9020 can perform demapping for mapping applied for transmission efficiency and correct an error generated on a transmission channel through decoding.", "In this case, the demapping & decoding module 9020 can obtain transmission parameters necessary for demapping and decoding by decoding the data output from the signaling decoding module 9040.The output processor 9030 can perform reverse procedures of various compression/signal processing procedures which are applied by the apparatus for transmitting broadcast signals to improve transmission efficiency.", "In this case, the output processor 9030 can acquire necessary control information from data output from the signaling decoding module 9040.The output of the output processor 8300 corresponds to a signal input to the apparatus for transmitting broadcast signals and may be MPEG-TSs, IP streams (v4 or v6) and generic streams.", "The signaling decoding module 9040 can obtain PLS information from the signal demodulated by the synchronization & demodulation module 9000.As described above, the frame parsing module 9010, demapping & decoding module 9020 and output processor 9030 can execute functions thereof using the data output from the signaling decoding module 9040.FIG.", "9 illustrates a frame structure according to an embodiment of the present invention.", "FIG.", "9 shows an example configuration of the frame types and FRUs in a super-frame.", "(a) shows a super frame according to an embodiment of the present invention, (b) shows FRU (Frame Repetition Unit) according to an embodiment of the present invention, (c) shows frames of variable PHY profiles in the FRU and (d) shows a structure of a frame.", "A super-frame may be composed of eight FRUs.", "The FRU is a basic multiplexing unit for TDM of the frames, and is repeated eight times in a super-frame.", "Each frame in the FRU belongs to one of the PHY profiles, (base, handheld, advanced) or FEF.", "The maximum allowed number of the frames in the FRU is four and a given PHY profile can appear any number of times from zero times to four times in the FRU (e.g., base, base, handheld, advanced).", "PHY profile definitions can be extended using reserved values of the PHY_PROFILE in the preamble, if required.", "The FEF part is inserted at the end of the FRU, if included.", "When the FEF is included in the FRU, the minimum number of FEFs is 8 in a super-frame.", "It is not recommended that FEF parts be adjacent to each other.", "One frame is further divided into a number of OFDM symbols and a preamble.", "As shown in (d), the frame comprises a preamble, one or more frame signaling symbols (FSS), normal data symbols and a frame edge symbol (FES).", "The preamble is a special symbol that enables fast Futurecast UTB system signal detection and provides a set of basic transmission parameters for efficient transmission and reception of the signal.", "The detailed description of the preamble will be will be described later.", "The main purpose of the FSS(s) is to carry the PLS data.", "For fast synchronization and channel estimation, and hence fast decoding of PLS data, the FSS has more dense pilot pattern than the normal data symbol.", "The FES has exactly the same pilots as the FSS, which enables frequency-only interpolation within the FES and temporal interpolation, without extrapolation, for symbols immediately preceding the FES.", "FIG.", "10 illustrates a signaling hierarchy structure of the frame according to an embodiment of the present invention.", "FIG.", "10 illustrates the signaling hierarchy structure, which is split into three main parts: the preamble signaling data 11000, the PLS1 data 11010 and the PLS2 data 11020.The purpose of the preamble, which is carried by the preamble symbol in every frame, is to indicate the transmission type and basic transmission parameters of that frame.", "The PLS1 enables the receiver to access and decode the PLS2 data, which contains the parameters to access the DP of interest.", "The PLS2 is carried in every frame and split into two main parts: PLS2-STAT data and PLS2-DYN data.", "The static and dynamic portion of PLS2 data is followed by padding, if necessary.", "FIG.", "11 illustrates preamble signaling data according to an embodiment of the present invention.", "Preamble signaling data carries 21 bits of information that are needed to enable the receiver to access PLS data and trace DPs within the frame structure.", "Details of the preamble signaling data are as follows: PHY_PROFILE: This 3-bit field indicates the PHY profile type of the current frame.", "The mapping of different PHY profile types is given in below table 5.TABLE 5 Value PHY profile 000 Base profile 001 Handheld profile 010 Advanced profiled 011~110 Reserved 111 FEF FFT_SIZE: This 2 bit field indicates the FFT size of the current frame within a frame-group, as described in below table 6.TABLE 6 Value FFT size 00 8K FFT 01 16K FFT 10 32K FFT 11 Reserved GI_FRACTION: This 3 bit field indicates the guard interval fraction value in the current super-frame, as described in below table 7.TABLE 7 Value GI_FRACTION 000 ⅕ 001 1/10 010 1/20 011 1/40 100 1/80 101 1/160 110~111 Reserved EAC_FLAG: This 1 bit field indicates whether the EAC is provided in the current frame.", "If this field is set to ‘1’, emergency alert service (EAS) is provided in the current frame.", "If this field set to ‘0’, EAS is not carried in the current frame.", "This field can be switched dynamically within a super-frame.", "PILOT_MODE: This 1-bit field indicates whether the pilot mode is mobile mode or fixed mode for the current frame in the current frame-group.", "If this field is set to ‘0’, mobile pilot mode is used.", "If the field is set to ‘1’, the fixed pilot mode is used.", "PAPR_FLAG: This 1-bit field indicates whether PAPR reduction is used for the current frame in the current frame-group.", "If this field is set to value ‘1’, tone reservation is used for PAPR reduction.", "If this field is set to ‘0’, PAPR reduction is not used.", "FRU_CONFIGURE: This 3-bit field indicates the PHY profile type configurations of the frame repetition units (FRU) that are present in the current super-frame.", "All profile types conveyed in the current super-frame are identified in this field in all preambles in the current super-frame.", "The 3-bit field has a different definition for each profile, as show in below table 8.TABLE 8 Current Current Current PHY_PROFILE = PHY_PROFILE = Current PHY_PROFILE = ‘001’ ‘010’ PHY_PROFILE = ‘000’ (base) (handheld) (advanced) ‘111’ (FEF) FRU_CONFIGURE = Only base Only handheld Only advanced Only FEF 000 profile present profile present profile present present FRU_CONFIGURE = Handheld Base profile Base profile Base profile 1XX profile present present present present FRU_CONFIGURE = Advanced Advanced Handheld Handheld X1X profile profile profile profile present present present present FRU_CONFIGURE = FEF FEF FEF Advanced XX1 present present present profile present RESERVED: This 7-bit field is reserved for future use.", "FIG.", "12 illustrates PLS1 data according to an embodiment of the present invention.", "PLS1 data provides basic transmission parameters including parameters required to enable the reception and decoding of the PLS2.As above mentioned, the PLS1 data remain unchanged for the entire duration of one frame-group.", "The detailed definition of the signaling fields of the PLS1 data are as follows: PREAMBLE_DATA: This 20-bit field is a copy of the preamble signaling data excluding the EAC_FLAG.", "NUM_FRAME_FRU: This 2-bit field indicates the number of the frames per FRU.", "PAYLOAD_TYPE: This 3-bit field indicates the format of the payload data carried in the frame-group.", "PAYLOAD_TYPE is signaled as shown in table 9.TABLE 9 value Payload type 1XX TS stream is transmitted X1X IP stream is transmitted XX1 GS stream is transmitted NUM_FSS: This 2-bit field indicates the number of FSS symbols in the current frame.", "SYSTEM_VERSION: This 8-bit field indicates the version of the transmitted signal format.", "The SYSTEM_VERSION is divided into two 4-bit fields, which are a major version and a minor version.", "Major version: The MSB four bits of SYSTEM_VERSION field indicate major version information.", "A change in the major version field indicates a non-backward-compatible change.", "The default value is ‘0000’.", "For the version described in this standard, the value is set to ‘0000’.", "Minor version: The LSB four bits of SYSTEM_VERSION field indicate minor version information.", "A change in the minor version field is backward-compatible.", "CELL_ID: This is a 16-bit field which uniquely identifies a geographic cell in an ATSC network.", "An ATSC cell coverage area may consist of one or more frequencies, depending on the number of frequencies used per Futurecast UTB system.", "If the value of the CELL_ID is not known or unspecified, this field is set to ‘0’.", "NETWORK_ID: This is a 16-bit field which uniquely identifies the current ATSC network.", "SYSTEM_ID: This 16-bit field uniquely identifies the Futurecast UTB system within the ATSC network.", "The Futurecast UTB system is the terrestrial broadcast system whose input is one or more input streams (TS, IP, GS) and whose output is an RF signal.", "The Futurecast UTB system carries one or more PHY profiles and FEF, if any.", "The same Futurecast UTB system may carry different input streams and use different RF frequencies in different geographical areas, allowing local service insertion.", "The frame structure and scheduling is controlled in one place and is identical for all transmissions within a Futurecast UTB system.", "One or more Futurecast UTB systems may have the same SYSTEM_ID meaning that they all have the same physical layer structure and configuration.", "The following loop consists of FRU_PHY_PROFILE, FRU_FRAME_LENGTH, FRU_GI_FRACTION, and RESERVED which are used to indicate the FRU configuration and the length of each frame type.", "The loop size is fixed so that four PHY profiles (including a FEF) are signaled within the FRU.", "If NUM_FRAME_FRU is less than 4, the unused fields are filled with zeros.", "FRU_PHY_PROFILE: This 3-bit field indicates the PHY profile type of the (i+1)th (i is the loop index) frame of the associated FRU.", "This field uses the same signaling format as shown in the table 8.FRU_FRAME_LENGTH: This 2-bit field indicates the length of the (i+1)th frame of the associated FRU.", "Using FRU_FRAME_LENGTH together with FRU_GI_FRACTION, the exact value of the frame duration can be obtained.", "FRU_GI_FRACTION: This 3-bit field indicates the guard interval fraction value of the (i+1)th frame of the associated FRU.", "FRU_GI_FRACTION is signaled according to the table 7.RESERVED: This 4-bit field is reserved for future use.", "The following fields provide parameters for decoding the PLS2 data.", "PLS2_FEC_TYPE: This 2-bit field indicates the FEC type used by the PLS2 protection.", "The FEC type is signaled according to table 10.The details of the LDPC codes will be described later.", "TABLE 10 Content PLS2 FEC type 00 4K-1/4 and 7K-3/10 LDPC codes 01~11 Reserved PLS2_MOD: This 3-bit field indicates the modulation type used by the PLS2.The modulation type is signaled according to table 11.TABLE 11 Value PLS2_MODE 000 BPSK 001 QPSK 010 QAM-16 011 NUQ-64 100~111 Reserved PLS2_SIZE_CELL: This 15-bit field indicates Ctotal_partial_block, the size (specified as the number of QAM cells) of the collection of full coded blocks for PLS2 that is carried in the current frame-group.", "This value is constant during the entire duration of the current frame-group.", "PLS2_STAT_SIZE_BIT: This 14-bit field indicates the size, in bits, of the PLS2-STAT for the current frame-group.", "This value is constant during the entire duration of the current frame-group.", "PLS2_DYN_SIZE_BIT: This 14-bit field indicates the size, in bits, of the PLS2-DYN for the current frame-group.", "This value is constant during the entire duration of the current frame-group.", "PLS2_REP_FLAG: This 1-bit flag indicates whether the PLS2 repetition mode is used in the current frame-group.", "When this field is set to value ‘1’, the PLS2 repetition mode is activated.", "When this field is set to value ‘0’, the PLS2 repetition mode is deactivated.", "PLS2_REP_SIZE_CELL: This 15-bit field indicates Ctotal_partial_block, the size (specified as the number of QAM cells) of the collection of partial coded blocks for PLS2 carried in every frame of the current frame-group, when PLS2 repetition is used.", "If repetition is not used, the value of this field is equal to 0.This value is constant during the entire duration of the current frame-group.", "PLS2_NEXT_FEC_TYPE: This 2-bit field indicates the FEC type used for PLS2 that is carried in every frame of the next frame-group.", "The FEC type is signaled according to the table 10.PLS2_NEXT_MOD: This 3-bit field indicates the modulation type used for PLS2 that is carried in every frame of the next frame-group.", "The modulation type is signaled according to the table 11.PLS2_NEXT_REP_FLAG: This 1-bit flag indicates whether the PLS2 repetition mode is used in the next frame-group.", "When this field is set to value ‘1’, the PLS2 repetition mode is activated.", "When this field is set to value ‘0’, the PLS2 repetition mode is deactivated.", "PLS2 NEXT_REP_SIZE_CELL: This 15-bit field indicates Ctotal_full_block, The size (specified as the number of QAM cells) of the collection of full coded blocks for PLS2 that is carried in every frame of the next frame-group, when PLS2 repetition is used.", "If repetition is not used in the next frame-group, the value of this field is equal to 0.This value is constant during the entire duration of the current frame-group.", "PLS2_NEXT_REP STAT_SIZE_BIT: This 14-bit field indicates the size, in bits, of the PLS2-STAT for the next frame-group.", "This value is constant in the current frame-group.", "PLS2_NEXT_REP DYN_SIZE_BIT: This 14-bit field indicates the size, in bits, of the PLS2-DYN for the next frame-group.", "This value is constant in the current frame-group.", "PLS2_AP_MODE: This 2-bit field indicates whether additional parity is provided for PLS2 in the current frame-group.", "This value is constant during the entire duration of the current frame-group.", "The below table 12 gives the values of this field.", "When this field is set to ‘00’, additional parity is not used for the PLS2 in the current frame-group.", "TABLE 12 Value PLS2-AP mode 00 AP is not provided 01 AP1 mode 10~11 Reserved PLS2_AP_SIZE_CELL: This 15-bit field indicates the size (specified as the number of QAM cells) of the additional parity bits of the PLS2.This value is constant during the entire duration of the current frame-group.", "PLS2_NEXT_AP_MODE: This 2-bit field indicates whether additional parity is provided for PLS2 signaling in every frame of next frame-group.", "This value is constant during the entire duration of the current frame-group.", "The table 12 defines the values of this field PLS2_NEXT_AP_SIZE_CELL: This 15-bit field indicates the size (specified as the number of QAM cells) of the additional parity bits of the PLS2 in every frame of the next frame-group.", "This value is constant during the entire duration of the current frame-group.", "RESERVED: This 32-bit field is reserved for future use.", "CRC_32: A 32-bit error detection code, which is applied to the entire PLS1 signaling.", "FIG.", "13 illustrates PLS2 data according to an embodiment of the present invention.", "FIG.", "13 illustrates PLS2-STAT data of the PLS2 data.", "The PLS2-STAT data are the same within a frame-group, while the PLS2-DYN data provide information that is specific for the current frame.", "The details of fields of the PLS2-STAT data are as follows: FIC_FLAG: This 1-bit field indicates whether the FIC is used in the current frame-group.", "If this field is set to ‘1’, the FIC is provided in the current frame.", "If this field set to ‘0’, the FIC is not carried in the current frame.", "This value is constant during the entire duration of the current frame-group.", "AUX_FLAG: This 1-bit field indicates whether the auxiliary stream(s) is used in the current frame-group.", "If this field is set to ‘1’, the auxiliary stream is provided in the current frame.", "If this field set to ‘0’, the auxiliary stream is not carried in the current frame.", "This value is constant during the entire duration of current frame-group.", "NUM_DP: This 6-bit field indicates the number of DPs carried within the current frame.", "The value of this field ranges from 1 to 64, and the number of DPs is NUM_DP+1.DP_ID: This 6-bit field identifies uniquely a DP within a PHY profile.", "DP_TYPE: This 3-bit field indicates the type of the DP.", "This is signaled according to the below table 13.TABLE 13 Value DP Type 000 DP Type 1 001 DP Type 2 010~111 reserved DP_GROUP_ID: This 8-bit field identifies the DP group with which the current DP is associated.", "This can be used by a receiver to access the DPs of the service components associated with a particular service, which will have the same DP_GROUP_ID.", "BASE_DP_ID: This 6-bit field indicates the DP carrying service signaling data (such as PSI/SI) used in the Management layer.", "The DP indicated by BASE_DP_ID may be either a normal DP carrying the service signaling data along with the service data or a dedicated DP carrying only the service signaling data.", "DP_FEC_TYPE: This 2-bit field indicates the FEC type used by the associated DP.", "The FEC type is signaled according to the below table 14.TABLE 14 Value FEC_TYPE 00 16K LDPC 01 64K LDPC 10~11 Reserved DP_COD: This 4-bit field indicates the code rate used by the associated DP.", "The code rate is signaled according to the below table 15.TABLE 15 Value Code rate 0000 5/15 0001 6/15 0010 7/15 0011 8/15 0100 9/15 0101 10/15 0110 11/15 0111 12/15 1000 13/15 1001~1111 Reserved DP_MOD: This 4-bit field indicates the modulation used by the associated DP.", "The modulation is signaled according to the below table 16.TABLE 16 Value Modulation 0000 QPSK 0001 QAM-16 0010 NUQ-64 0011 NUQ-256 0100 NUQ-1024 0101 NUC-16 0110 NUC-64 0111 NUC-256 1000 NUC-1024 1001~1111 reserved DP_SSD_FLAG: This 1-bit field indicates whether the SSD mode is used in the associated DP.", "If this field is set to value ‘1’, SSD is used.", "If this field is set to value ‘0’, SSD is not used.", "The following field appears only if PHY_PROFILE is equal to ‘010’, which indicates the advanced profile: DP_MIMO: This 3-bit field indicates which type of MIMO encoding process is applied to the associated DP.", "The type of MIMO encoding process is signaled according to the table 17.TABLE 17 Value MIMO encoding 000 FR-SM 001 FRFD-SM 010~111 reserved DP_TI_TYPE: This 1-bit field indicates the type of time-interleaving.", "A value of ‘0’ indicates that one TI group corresponds to one frame and contains one or more TI-blocks.", "A value of ‘1’ indicates that one TI group is carried in more than one frame and contains only one TI-block.", "DP_TI_LENGTH: The use of this 2-bit field (the allowed values are only 1, 2, 4, 8) is determined by the values set within the DP_TI_TYPE field as follows: If the DP_TI_TYPE is set to the value ‘1’, this field indicates PI, the number of the frames to which each TI group is mapped, and there is one TI-block per TI group (NTI=1).", "The allowed PI values with 2-bit field are defined in the below table 18.If the DP_TI_TYPE is set to the value ‘0’, this field indicates the number of TI-blocks NTI per TI group, and there is one TI group per frame (PI=1).", "The allowed PI values with 2-bit field are defined in the below table 18.TABLE 18 2-bit field PI NTI 00 1 1 01 2 2 10 4 3 11 8 4 DP_FRAME_INTERVAL: This 2-bit field indicates the frame interval (HUMP) within the frame-group for the associated DP and the allowed values are 1, 2, 4, 8 (the corresponding 2-bit field is ‘00’, ‘01’, ‘10’, or ‘11’, respectively).", "For DPs that do not appear every frame of the frame-group, the value of this field is equal to the interval between successive frames.", "For example, if a DP appears on the frames 1, 5, 9, 13, etc., this field is set to ‘4’.", "For DPs that appear in every frame, this field is set to ‘1’.", "DP_TI_BYPASS: This 1-bit field determines the availability of time interleaver 5050.If time interleaving is not used for a DP, it is set to ‘1’.", "Whereas if time interleaving is used it is set to ‘0’.", "DP_FIRST_FRAME_IDX: This 5-bit field indicates the index of the first frame of the super-frame in which the current DP occurs.", "The value of DP_FIRST_FRAME_IDX ranges from 0 to 31.DP_NUM_BLOCK_MAX: This 10-bit field indicates the maximum value of DP_NUM_BLOCKS for this DP.", "The value of this field has the same range as DP_NUM_BLOCKS.", "DP_PAYLOAD_TYPE: This 2-bit field indicates the type of the payload data carried by the given DP.", "DP_PAYLOAD_TYPE is signaled according to the below table 19.TABLE 19 Value Payload Type 00 TS.", "01 IP 10 GS 11 reserved DP_INBAND_MODE: This 2-bit field indicates whether the current DP carries in-band signaling information.", "The in-band signaling type is signaled according to the below table 20.TABLE 20 Value In-band mode 00 In-band signaling is not carried.", "01 INBAND-PLS is carried only 10 INBAND-ISSY is carried only 11 INBAND-PLS and INBAND-ISSY are carried DP_PROTOCOL_TYPE: This 2-bit field indicates the protocol type of the payload carried by the given DP.", "It is signaled according to the below table 21 when input payload types are selected.", "TABLE 21 If If If DP_PAYLOAD_TYPE DP_PAYLOAD_TYPE DP_PAYLOAD_TYPE Value Is TS Is IP Is GS 00 MPEG2-TS IPv4 (Note) 01 Reserved IPv6 Reserved 10 Reserved Reserved Reserved 11 Reserved Reserved Reserved DP_CRC_MODE: This 2-bit field indicates whether CRC encoding is used in the Input Formatting block.", "The CRC mode is signaled according to the below table 22.TABLE 22 Value CRC mode 00 Not used 01 CRC-8 10 CRC-16 11 CRC-32 DNP_MODE: This 2-bit field indicates the null-packet deletion mode used by the associated DP when DP_PAYLOAD_TYPE is set to TS (‘00’).", "DNP_MODE is signaled according to the below table 23.If DP_PAYLOAD_TYPE is not TS (‘00’), DNP_MODE is set to the value ‘00’.", "TABLE 23 Value Null-packet deletion mode 00 Not used 01 DNP-NORMAL 10 DNP-OFFSET 11 reserved ISSY_MODE: This 2-bit field indicates the ISSY mode used by the associated DP when DP_PAYLOAD_TYPE is set to TS (‘00’).", "The ISSY_MODE is signaled according to the below table 24 If DP_PAYLOAD_TYPE is not TS (‘00’), ISSY_MODE is set to the value ‘00’.", "TABLE 24 Value ISSY mode 00 Not used 01 ISSY-UP 10 ISSY-BBF 11 reserved HC_MODE_TS: This 2-bit field indicates the TS header compression mode used by the associated DP when DP_PAYLOAD_TYPE is set to TS (‘00’).", "The HC_MODE_TS is signaled according to the below table 25.TABLE 25 Value Header compression mode 00 HC_MODE_TS 1 01 HC_MODE_TS 2 10 HC_MODE_TS 3 11 HC_MODE_TS 4 HC_MODE_IP: This 2-bit field indicates the IP header compression mode when DP_PAYLOAD_TYPE is set to IP (‘01’).", "The HC_MODE_IP is signaled according to the below table 26.TABLE 26 Value Header compression mode 00 No compression 01 HC_MODE_IP 1 10~11 reserved PID: This 13-bit field indicates the PID number for TS header compression when DP_PAYLOAD_TYPE is set to TS (‘00’) and HC_MODE_TS is set to ‘01’ or ‘10’.", "RESERVED: This 8-bit field is reserved for future use.", "The following field appears only if FIC_FLAG is equal to ‘1’: FIC_VERSION: This 8-bit field indicates the version number of the FIC.", "FIC_LENGTH_BYTE: This 13-bit field indicates the length, in bytes, of the FIC.", "RESERVED: This 8-bit field is reserved for future use.", "The following field appears only if AUX_FLAG is equal to ‘1’: NUM_AUX: This 4-bit field indicates the number of auxiliary streams.", "Zero means no auxiliary streams are used.", "AUX_CONFIG_RFU: This 8-bit field is reserved for future use.", "AUX_STREAM_TYPE: This 4-bit is reserved for future use for indicating the type of the current auxiliary stream.", "AUX_PRIVATE_CONFIG: This 28-bit field is reserved for future use for signaling auxiliary streams.", "FIG.", "14 illustrates PLS2 data according to another embodiment of the present invention.", "FIG.", "14 illustrates PLS2-DYN data of the PLS2 data.", "The values of the PLS2-DYN data may change during the duration of one frame-group, while the size of fields remains constant.", "The details of fields of the PLS2-DYN data are as follows: FRAME_INDEX: This 5-bit field indicates the frame index of the current frame within the super-frame.", "The index of the first frame of the super-frame is set to ‘0’.", "PLS_CHANGE_COUNTER: This 4-bit field indicates the number of super-frames ahead where the configuration will change.", "The next super-frame with changes in the configuration is indicated by the value signaled within this field.", "If this field is set to the value ‘0000’, it means that no scheduled change is foreseen: e.g., value ‘1’ indicates that there is a change in the next super-frame.", "FIC_CHANGE_COUNTER: This 4-bit field indicates the number of super-frames ahead where the configuration (i.e., the contents of the FIC) will change.", "The next super-frame with changes in the configuration is indicated by the value signaled within this field.", "If this field is set to the value ‘0000’, it means that no scheduled change is foreseen: e.g.", "value ‘0001’ indicates that there is a change in the next super-frame.", "RESERVED: This 16-bit field is reserved for future use.", "The following fields appear in the loop over NUM_DP, which describe the parameters associated with the DP carried in the current frame.", "DP_ID: This 6-bit field indicates uniquely the DP within a PHY profile.", "DP_START: This 15-bit (or 13-bit) field indicates the start position of the first of the DPs using the DPU addressing scheme.", "The DP_START field has differing length according to the PHY profile and FFT size as shown in the below table 27.TABLE 27 DP_START field size PHY profile 64K 16K Base 13 bit 15 bit Handheld — 13 bit Advanced 13 bit 15 bit DP_NUM_BLOCK: This 10-bit field indicates the number of FEC blocks in the current TI group for the current DP.", "The value of DP_NUM_BLOCK ranges from 0 to 1023.RESERVED: This 8-bit field is reserved for future use.", "The following fields indicate the FIC parameters associated with the EAC.", "EAC_FLAG: This 1-bit field indicates the existence of the EAC in the current frame.", "This bit is the same value as the EAC_FLAG in the preamble.", "EAS_WAKE_UP_VERSION_NUM: This 8-bit field indicates the version number of a wake-up indication.", "If the EAC_FLAG field is equal to ‘1’, the following 12 bits are allocated for EAC_LENGTH_BYTE field.", "If the EAC_FLAG field is equal to ‘0’, the following 12 bits are allocated for EAC_COUNTER.", "EAC_LENGTH_BYTE: This 12-bit field indicates the length, in byte, of the EAC.", "EAC_COUNTER: This 12-bit field indicates the number of the frames before the frame where the EAC arrives.", "The following field appears only if the AUX_FLAG field is equal to ‘1’: AUX_PRIVATE_DYN: This 48-bit field is reserved for future use for signaling auxiliary streams.", "The meaning of this field depends on the value of AUX_STREAM_TYPE in the configurable PLS2-STAT.", "CRC_32: A 32-bit error detection code, which is applied to the entire PLS2.FIG.", "15 illustrates a logical structure of a frame according to an embodiment of the present invention.", "As above mentioned, the PLS, EAC, FIC, DPs, auxiliary streams and dummy cells are mapped into the active carriers of the OFDM symbols in the frame.", "The PLS1 and PLS2 are first mapped into one or more FSS(s).", "After that, EAC cells, if any, are mapped immediately following the PLS field, followed next by FIC cells, if any.", "The DPs are mapped next after the PLS or EAC, FIC, if any.", "Type 1 DPs follows first, and Type 2 DPs next.", "The details of a type of the DP will be described later.", "In some case, DPs may carry some special data for EAS or service signaling data.", "The auxiliary stream or streams, if any, follow the DPs, which in turn are followed by dummy cells.", "Mapping them all together in the above mentioned order, i.e.", "PLS, EAC, FIC, DPs, auxiliary streams and dummy data cells exactly fill the cell capacity in the frame.", "FIG.", "16 illustrates PLS mapping according to an embodiment of the present invention.", "PLS cells are mapped to the active carriers of FSS(s).", "Depending on the number of cells occupied by PLS, one or more symbols are designated as FSS(s), and the number of FSS(s) NFSS is signaled by NUM_FSS in PLS1.The FSS is a special symbol for carrying PLS cells.", "Since robustness and latency are critical issues in the PLS, the FSS(s) has higher density of pilots allowing fast synchronization and frequency-only interpolation within the FSS.", "PLS cells are mapped to active carriers of the NFSS FSS(s) in a top-down manner as shown in an example in FIG.", "16.The PLS1 cells are mapped first from the first cell of the first FSS in an increasing order of the cell index.", "The PLS2 cells follow immediately after the last cell of the PLS1 and mapping continues downward until the last cell index of the first FSS.", "If the total number of required PLS cells exceeds the number of active carriers of one FSS, mapping proceeds to the next FSS and continues in exactly the same manner as the first FSS.", "After PLS mapping is completed, DPs are carried next.", "If EAC, FIC or both are present in the current frame, they are placed between PLS and “normal” DPs.", "FIG.", "17 illustrates EAC mapping according to an embodiment of the present invention.", "EAC is a dedicated channel for carrying EAS messages and links to the DPs for EAS.", "EAS support is provided but EAC itself may or may not be present in every frame.", "EAC, if any, is mapped immediately after the PLS2 cells.", "EAC is not preceded by any of the FIC, DPs, auxiliary streams or dummy cells other than the PLS cells.", "The procedure of mapping the EAC cells is exactly the same as that of the PLS.", "The EAC cells are mapped from the next cell of the PLS2 in increasing order of the cell index as shown in the example in FIG.", "17.Depending on the EAS message size, EAC cells may occupy a few symbols, as shown in FIG.", "17.EAC cells follow immediately after the last cell of the PLS2, and mapping continues downward until the last cell index of the last FSS.", "If the total number of required EAC cells exceeds the number of remaining active carriers of the last FSS mapping proceeds to the next symbol and continues in exactly the same manner as FSS(s).", "The next symbol for mapping in this case is the normal data symbol, which has more active carriers than a FSS.", "After EAC mapping is completed, the FIC is carried next, if any exists.", "If FIC is not transmitted (as signaled in the PLS2 field), DPs follow immediately after the last cell of the EAC.", "FIG.", "18 illustrates FIC mapping according to an embodiment of the present invention.", "shows an example mapping of FIC cell without EAC and (b) shows an example mapping of FIC cell with EAC.", "FIC is a dedicated channel for carrying cross-layer information to enable fast service acquisition and channel scanning.", "This information primarily includes channel binding information between DPs and the services of each broadcaster.", "For fast scan, a receiver can decode FIC and obtain information such as broadcaster ID, number of services, and BASE_DP_ID.", "For fast service acquisition, in addition to FIC, base DP can be decoded using BASE_DP_ID.", "Other than the content it carries, a base DP is encoded and mapped to a frame in exactly the same way as a normal DP.", "Therefore, no additional description is required for a base DP.", "The FIC data is generated and consumed in the Management Layer.", "The content of FIC data is as described in the Management Layer specification.", "The FIC data is optional and the use of FIC is signaled by the FIC_FLAG parameter in the static part of the PLS2.If FIC is used, FIC_FLAG is set to ‘1’ and the signaling field for FIC is defined in the static part of PLS2.Signaled in this field are FIC_VERSION, and FIC_LENGTH_BYTE.", "FIC uses the same modulation, coding and time interleaving parameters as PLS2.FIC shares the same signaling parameters such as PLS2_MOD and PLS2_FEC.", "FIC data, if any, is mapped immediately after PLS2 or EAC if any.", "FIC is not preceded by any normal DPs, auxiliary streams or dummy cells.", "The method of mapping FIC cells is exactly the same as that of EAC which is again the same as PLS.", "Without EAC after PLS, FIC cells are mapped from the next cell of the PLS2 in an increasing order of the cell index as shown in an example in (a).", "Depending on the FIC data size, FIC cells may be mapped over a few symbols, as shown in (b).", "FIC cells follow immediately after the last cell of the PLS2, and mapping continues downward until the last cell index of the last FSS.", "If the total number of required FIC cells exceeds the number of remaining active carriers of the last FSS, mapping proceeds to the next symbol and continues in exactly the same manner as FSS(s).", "The next symbol for mapping in this case is the normal data symbol which has more active carriers than a FSS.", "If EAS messages are transmitted in the current frame, EAC precedes FIC, and FIC cells are mapped from the next cell of the EAC in an increasing order of the cell index as shown in (b).", "After FIC mapping is completed, one or more DPs are mapped, followed by auxiliary streams, if any, and dummy cells.", "FIG.", "19 illustrates an FEC structure according to an embodiment of the present invention.", "FIG.", "19 illustrates an FEC structure according to an embodiment of the present invention before bit interleaving.", "As above mentioned, Data FEC encoder may perform the FEC encoding on the input BBF to generate FECBLOCK procedure using outer coding (BCH), and inner coding (LDPC).", "The illustrated FEC structure corresponds to the FECBLOCK.", "Also, the FECBLOCK and the FEC structure have same value corresponding to a length of LDPC codeword.", "The BCH encoding is applied to each BBF (Kbch bits), and then LDPC encoding is applied to BCH-encoded BBF (Kldpc bits=Nbch bits) as illustrated in FIG.", "22.The value of Nldpc is either 64800 bits (long FECBLOCK) or 16200 bits (short FECBLOCK).", "The below table 28 and table 29 show FEC encoding parameters for a long FECBLOCK and a short FECBLOCK, respectively.", "TABLE 28 BCH error LDPC correction Nbch − Rate Nldpc Kldpc Kbch capability Kbch 5/15 64800 21600 21408 12 192 6/15 25920 25728 7/15 30240 30048 8/15 34560 34368 9/15 38880 38688 10/15 43200 43008 11/15 47520 47328 12/15 51840 51648 13/15 56160 55968 TABLE 29 BCH error LDPC correction Nbch − Rate Nldpc Kldpc Kbch capability Kbch 5/15 16200 5400 5232 12 168 6/15 6480 6312 7/15 7560 7392 8/15 8640 8472 9/15 9720 9552 10/15 10800 10632 11/15 11880 11712 12/15 12960 12792 13/15 14040 13872 The details of operations of the BCH encoding and LDPC encoding are as follows: A 12-error correcting BCH code is used for outer encoding of the BBF.", "The BCH generator polynomial for short FECBLOCK and long FECBLOCK are obtained by multiplying together all polynomials.", "LDPC code is used to encode the output of the outer BCH encoding.", "To generate a completed Bldpc (FECBLOCK), Pldpc (parity bits) is encoded systematically from each Ildpc (BCH-encoded BBF), and appended to Ildpc.", "The completed Bldpc (FECBLOCK) are expressed as following equation.", "Bldpc=[IldpcPldpc]=[i0,i1, .", ".", ".", "iKldpc−1,p0,p1, .", ".", ".", ",pNldpc−Kldpc−1] [Equation2] The parameters for long FECBLOCK and short FECBLOCK are given in the above table 28 and 29, respectively.", "The detailed procedure to calculate Nldpc−Kldpc parity bits for long FECBLOCK, is as follows: 1) Initialize the parity bits, p0=p1=p2= .", ".", ".", "=pNldpc−Kldpc−1=0 [Equation3] 2) Accumulate the first information bit-i0, at parity bit addresses specified in the first row of an addresses of parity check matrix.", "The details of addresses of parity check matrix will be described later.", "For example, for rate 13/15: p983=p983⊕i0 p2815=p2815⊕i0 p4837=p4837⊕i0 p4989=p4989⊕i0 p6138=p6138⊕i0 p6458=p6458⊕i0 p6921=p6921⊕i0 p6974=p6974⊕i0 p7572=p7572⊕i0 p8260=p8260⊕i0 p8496=p8496⊕i0 [Equation 4] 3) For the next 359 information bits, is, s=1, 2, .", ".", ".", ", 359 accumulate is at parity bit addresses using following equation.", "{x+(s mod 360)×Qldpc} mod (Nldpc−Kldpc) [Equation 5] where x denotes the address of the parity bit accumulator corresponding to the first bit i0, and Qldpc is a code rate dependent constant specified in the addresses of parity check matrix.", "Continuing with the example, Qldpc=24 for rate 13/15, so for information bit i1, the following operations are performed: p1007=p1007⊕i1 p2839=p2839⊕i1 p4861=p4861⊕i1 p5013=p5013⊕i1 p6162=p6162⊕i1 p6482=p6482⊕i1 p6945=p6945⊕i1 p6998=p6998⊕i1 p7596=p7596⊕i1 p8284=p8284⊕i1 p8520=p8520⊕i1 [Equation 6] 4) For the 361st information bit i360, the addresses of the parity bit accumulators are given in the second row of the addresses of parity check matrix.", "In a similar manner the addresses of the parity bit accumulators for the following 359 information bits is, s=361, 362, .", ".", ".", ", 719 are obtained using the equation 6, where x denotes the address of the parity bit accumulator corresponding to the information bit i360, i.e., the entries in the second row of the addresses of parity check matrix.", "5) In a similar manner, for every group of 360 new information bits, a new row from addresses of parity check matrixes used to find the addresses of the parity bit accumulators.", "After all of the information bits are exhausted, the final parity bits are obtained as follows: 6) Sequentially perform the following operations starting with i=1.pi=pi⊕pi-1,i=1,2, .", ".", ".", ",Nldpc−Kldpc−1 [Equation 7] where final content of pi, i=0, 1, .", ".", ".", ", Nldpc−Kldpc−1 is equal to the parity bit pi.", "TABLE 30 Code Rate Qldpc 5/15 120 6/15 108 7/15 96 8/15 84 9/15 72 10/15 60 11/15 48 12/15 36 13/15 24 This LDPC encoding procedure for a short FECBLOCK is in accordance with the LDPC encoding procedure for the long FECBLOCK, except replacing the table 30 with table 31, and replacing the addresses of parity check matrix for the long FECBLOCK with the addresses of parity check matrix for the short FECBLOCK.", "TABLE 31 Code Rate Qldpc 5/15 30 6/15 27 7/15 24 8/15 21 9/15 18 10/15 15 11/15 12 12/15 9 13/15 6 FIG.", "20 illustrates a time interleaving according to an embodiment of the present invention.", "(a) to (c) show examples of TI mode.", "The time interleaver operates at the DP level.", "The parameters of time interleaving (TI) may be set differently for each DP.", "The following parameters, which appear in part of the PLS2-STAT data, configure the TI: DP_TI_TYPE (allowed values: 0 or 1): Represents the TI mode; ‘0’ indicates the mode with multiple TI blocks (more than one TI block) per TI group.", "In this case, one TI group is directly mapped to one frame (no inter-frame interleaving).", "‘1’ indicates the mode with only one TI block per TI group.", "In this case, the TI block may be spread over more than one frame (inter-frame interleaving).", "DP_TI_LENGTH: If DP_TI_TYPE=‘0’, this parameter is the number of TI blocks NTI per TI group.", "For DP_TI_TYPE=‘1’, this parameter is the number of frames PI spread from one TI group.", "DP_NUM_BLOCK_MAX (allowed values: 0 to 1023): Represents the maximum number of XFECBLOCKs per TI group.", "DP_FRAME_INTERVAL (allowed values: 1, 2, 4, 8): Represents the number of the frames IJUMP between two successive frames carrying the same DP of a given PHY profile.", "DP_TI_BYPASS (allowed values: 0 or 1): If time interleaving is not used for a DP, this parameter is set to ‘1’.", "It is set to ‘0’ if time interleaving is used.", "Additionally, the parameter DP_NUM_BLOCK from the PLS2-DYN data is used to represent the number of XFECBLOCKs carried by one TI group of the DP.", "When time interleaving is not used for a DP, the following TI group, time interleaving operation, and TI mode are not considered.", "However, the Delay Compensation block for the dynamic configuration information from the scheduler will still be required.", "In each DP, the XFECBLOCKs received from the SSD/MIMO encoding are grouped into TI groups.", "That is, each TI group is a set of an integer number of XFECBLOCKs and will contain a dynamically variable number of XFECBLOCKs.", "The number of XFECBLOCKs in the TI group of index n is denoted by NxBLOCK_Group(n) and is signaled as DP_NUM_BLOCK in the PLS2-DYN data.", "Note that NxBLOCK_Group(n) may vary from the minimum value of 0 to the maximum value NxBLOCK_Group_MAX (corresponding to DP_NUM_BLOCK_MAX) of which the largest value is 1023.Each TI group is either mapped directly onto one frame or spread over PI frames.", "Each TI group is also divided into more than one TI blocks(NTI), where each TI block corresponds to one usage of time interleaver memory.", "The TI blocks within the TI group may contain slightly different numbers of XFECBLOCKs.", "If the TI group is divided into multiple TI blocks, it is directly mapped to only one frame.", "There are three options for time interleaving (except the extra option of skipping the time interleaving) as shown in the below table 32.TABLE 32 Modes Descriptions Option-1 Each TI group contains one TI block and is mapped directly to one frame as shown in (a).", "This option is signaled in the PLS2-STAT by DP_TI_TYPE = ‘0’ and DP_TI_LENGTH = ‘1’(NTI = 1).", "Option-2 Each TI group contains one TI block and is mapped to more than one frame.", "(b) shows an example, where one TI group is mapped to two frames, i.e., DP_TI_LENGTH = ‘2’ (PI = 2) and DP_FRAME_INTERVAL (IJUMP = 2).", "This provides greater time diversity for low data-rate services.", "This option is signaled in the PLS2-STAT by DP_TI_TYPE = ‘1’.", "Option-3 Each TI group is divided into multiple TI blocks and is mapped directly to one frame as shown in (c).", "Each TI block may use full TI memory, so as to provide the maximum bit-rate for a DP.", "This option is signaled in the PLS2-STAT signaling by DP_TI_TYPE = ‘0’ and DP_TI_LENGTH = NTI, while PI = 1.Typically, the time interleaver will also act as a buffer for DP data prior to the process of frame building.", "This is achieved by means of two memory banks for each DP.", "The first TI-block is written to the first bank.", "The second TI-block is written to the second bank while the first bank is being read from and so on.", "The TI is a twisted row-column block interleaver.", "For the sth TI block of the nth TI group, the number of rows Nr of a TI memory is equal to the number of cells Ncells, i.e., Nr=Ncells while the number of columns Nc is equal to the number NxBLOCK_TI (ns).", "FIG.", "21 illustrates the basic operation of a twisted row-column block interleaver according to an embodiment of the present invention.", "FIG.", "21(a) shows a writing operation in the time interleaver and FIG.", "21(b) shows a reading operation in the time interleaver The first XFECBLOCK is written column-wise into the first column of the TI memory, and the second XFECBLOCK is written into the next column, and so on as shown in (a).", "Then, in the interleaving array, cells are read out diagonal-wise.", "During diagonal-wise reading from the first row (rightwards along the row beginning with the left-most column) to the last row, Nr cells are read out as shown in (b).", "In detail, assuming zn,s,i (i=0, .", ".", ".", ", NrNc) as the TI memory cell position to be read sequentially, the reading process in such an interleaving array is performed by calculating the row index Rn,s,i, the column index Cn,s,i, and the associated twisting parameter Tn,s,i as follows equation.", "GENERATE  ( R n , s , i , C n , s , i ) =  {  R n , s , i = mod  ( i , N r ) ,  T n , s , i = mod  ( S shift × R n , s , i , N c ) ,  C n , s , i = mod  ( T n , s , i + ⌊ i N r ⌋ , N c )  } [ Equation   8 ] where Sshift is a common shift value for the diagonal-wise reading process regardless of NxBLOCK_TI (n,s), and it is determined by NxBLOCK_TI_MAX given in the PLS2-STAT as follows equation.", " [ Equation   9 ] for   { N xBLOCK_TI  _MAX ′ = N xBLOCK_TI  _MAX + 1 , if   N xBLOCK_TI  _MAX  mod   2 = 0 N xBLOCK_TI  _MAX ′ = N xBLOCK_TI  _MAX , if   N xBLOCK_TI  _MAX  mod   2 = 1 ,   S shift = N xBLOCK_TI  _MAX ′ - 1 2 As a result, the cell positions to be read are calculated by a coordinate as zn,s,i=NrCn,s,i+Rn,s,i.", "FIG.", "22 illustrates an operation of a twisted row-column block interleaver according to another embodiment of the present invention.", "More specifically, FIG.", "22 illustrates the interleaving array in the TI memory for each TI group, including virtual XFECBLOCKs when NxBLOCK_TI(0,0)=3, NxRLOCK_TI (1,0)=6, NxBLOCK_TI (2,0)=5.The variable number Nxblock_TI(n,s)=Nr will be less than or equal to N′xBLOCK_TI_MAX.", "Thus, in order to achieve a single-memory deinterleaving at the receiver side, regardless of NxBLOCK_TI(n,s), the interleaving array for use in a twisted row-column block interleaver is set to the size of Nr×Nc=Ncells×N′xBLOCK_TI_MAX by inserting the virtual XFECBLOCKs into the TI memory and the reading process is accomplished as follow equation.", "[Equation10] p = 0; for i = 0; i < NcellsN′xBLOCK—TI—MAX; i = i + 1 {GENERATE (Rn,s,i, Cn,s,i); Vi = NrCn,s,j + Rn,s,j if Vi < NcellsNxBLOCK—TI(n,s) { Zn,s,p = Vi; p = p + 1; } } The number of TI groups is set to 3.The option of time interleaver is signaled in the PLS2-STAT data by DP_TI_TYPE=‘0’, DP_FRAME_INTERVAL=‘1’, and DP_TI_LENGTH=‘1’, i.e., NTI=1, IJUMP=1, and PI=1.The number of XFECBLOCKs, each of which has Ncells=30 cells, per TI group is signaled in the PLS2-DYN data by NxBLOCK_TI(0,0)=3, NxBLOCK_TI(1,0)=6, and NxBLOCK_TI(2,0)=5, respectively.", "The maximum number of XFECBLOCK is signaled in the PLS2-STAT data by NxBLOCK_Group_MAX, which leads to └NxBLOCK_Group_MAX/NTI┘=NxBLOCK_TI_MAX=6.FIG.", "23 illustrates a diagonal-wise reading pattern of a twisted row-column block interleaver according to an embodiment of the present invention.", "More specifically FIG.", "23 shows a diagonal-wise reading pattern from each interleaving array with parameters of N′xBLOCK_TI_MAX=7 and Sshift=(7−1)/2=3.Note that in the reading process shown as pseudocode above, if Vi≥NcellsNxBLOCK_TI(n,s), the value of Vi is skipped and the next calculated value of Vi is used.", "FIG.", "24 illustrates interleaved XFECBLOCKs from each interleaving array according to an embodiment of the present invention.", "FIG.", "24 illustrates the interleaved XFECBLOCKs from each interleaving array with parameters of N′xBLOCK_TI_MAX=7 and Sshift=3.FIG.", "25 is a block diagram illustrating a main physical device and a companion physical device according to an embodiment of the present invention.", "The embodiment of the present invention can provide a service guide in a terrestrial broadcast environment or a mobile broadcast environment.", "In addition, the embodiment of the present invention can provide a service guide regarding services available in the next generation hybrid broadcast environment based on interaction between a terrestrial broadcast network and the Internet.", "The embodiment of the present invention can inform users of not only various services available in the next generation hybrid broadcast system, but also constituent content of the services and/or component elements of the services.", "As a result, the user can easily confirm, select, and view the corresponding service, resulting in increased user convenience.", "The embodiment of the present invention may construct a single service, various constituent content of the service, and/or component elements of the service, and may make a cross reference to each other.", "As a result, the broadcast receiver can easily construct and provide the corresponding service, and can allow the user to easily recognize the corresponding service.", "The embodiments of the present invention can extend the reference structure for linking one service to various content and/or component elements of the service, and can allow the broadcast receiver and/or the user to reduce the amount of resources and/or consumption time needed to search for content and/or component elements of the single service.", "FIG.", "25 is a block diagram illustrating a main physical device and a companion physical device according to an embodiment of the present invention.", "The main physical device (L25010) according to an embodiment of the present invention is one of devices for interactive services, and may indicate a target device to be controlled by the companion physical device (L25020).", "The main physical device may be referred to as a main device, a main reception device, a main display, a main screen, or the like.", "The main physical device (L25010) according to one embodiment of the present invention may include a broadcast interface (L25030), a network interface (L25040), a memory unit (L25050), a control unit (L25060), a display unit (L25070), a multimedia module (L25080), a storage unit (L25090), a power-supply unit (L25100), and/or a user input interface (L25110).", "The broadcast interface (L25030) may indicate a physical device located between the broadcaster and the device, such that the broadcast interface (L25030) acting as the physical device can transmit various messages (such as the AV stream, service guide, and notification messages) and/or data.", "The broadcast interface (L25030) may receive broadcast signals, signaling information, data, etc.", "from the broadcaster.", "The network interface (L25040) may indicate a physical device located between various devices (e.g., the main physical device and the companion physical device), such that the network interface (L25040) can transmit various messages (e.g., commands, requests, actions, response messages, etc.", "), and can perform advertising and/or data transmission.", "The network interface may receive broadcast services, broadcast content, signaling information, applications, data, etc.", "from the Internet service provider.", "The memory unit (L25050) may be an optional or selective device implemented in various types of devices, and may indicate a volatile physical device capable of temporarily storing various types of data.", "The control unit (L25060) may be configured to control the entire operation of the source device and/or the sink device, and may be implemented by software or hardware.", "In this case, the source device may indicate a device configured to transmit messages and/or data.", "The sink device may indicate a device configured to receive messages and/or data.", "Therefore, the main physical device and the companion physical device according to the embodiment of the present invention may correspond to the source device or the sink device.", "The display unit (L25070) may display data received through the network interface or data stored in the storage unit on the screen.", "In this case, the display unit may be controlled by the control unit.", "The multimedia module (L25080) may reproduce various types of multimedia.", "The multimedia module may be contained in the control unit, and may be located independently of the control unit.", "The storage unit (L25090) may indicate a non-volatile physical device capable of storing various types of data therein.", "For example, the SC card may correspond to the storage unit.", "The power-supply unit (L25100) may receive the external power-supply voltage and/or the internal power-supply voltage under control of the control unit, such that the power-supply unit (L25100) can provide a power-supply voltage needed to operate other constituent elements.", "The user input interface (L25110) may indicate a device capable of receiving input signals or commands from the user.", "The companion physical device (L25020) according to the embodiment of the present invention may be one of devices needed for interactive services, and may indicate a device configured to control the main device.", "Generally, the companion physical device may directly receive input signals from the user.", "The companion physical device may be referred to as a companion device, a second device, an additional device, an auxiliary device, a companion reception device, a companion receiver, a companion display, a second screen, or the like.", "The physical device (L25020) according to the embodiment of the present invention may include a network interface, a memory unit, a control unit, a display unit, a multimedia module, a storage unit, a power-supply unit, and/or a user input interface.", "From among all the constituent elements of the companion physical device according to the embodiment, some constituent elements having the same names as those of the main device may have the same functions as those of the constituent elements of the above-mentioned main device.", "FIG.", "26 is a block diagram illustrating a protocol stack configured to support a hybrid broadcast service according to an embodiment of the present invention.", "A physical layer may receive terrestrial broadcast signals, and may properly convert (or transform) the received terrestrial broadcast signals.", "IP (Internet Protocol) Encapsulation may acquire an IP datagram using information acquired from the physical layer.", "In addition, the IP encapsulation may convert (or transform) the acquired IP datagram into a specific frame (e.g., RS Frame, GSE, etc.).", "MPEG2 TS Encapsulation may acquire the MPEG2 TS using information acquired from the physical layer.", "In addition, the MPEG2 TS Encapsulation may convert the acquired MPEG2 TS datagram into a specific frame (e.g., RS Frame, GSE, etc.).", "A Fast Information Channel (FIC) may transmit specific information (e.g., mapping information between the service ID and the frame) so as to access the service and/or content.", "Signaling may include signaling information to support a hybrid broadcast service according to an embodiment of the present invention.", "This signaling information may include signaling information to support efficient acquisition of the services and/or content.", "This signaling information may be denoted in binary and/or XML format, and may be transmitted through the terrestrial broadcast network and/or the broadband network.", "Real time A/V (Audio/Video) content and data may be represented by ISO Base Media File Format (ISOBMFF) or the like, and may be transmitted in real time through the terrestrial broadcast network and/or the broadband network.", "Non-real time content may be transmitted on the basis of IP/UDP/FLUTE.", "Real-time broadcast A/V (Audio/Video) content, data and/or signaling information may be transmitted in real time through the Internet.", "In this case, the real-time broadcast A/V (Audio/Video) content, data and/or signaling information may be transmitted by a request message.", "Alternatively, the real-time broadcast A/V (Audio/Video) content, data and/or signaling information may also be transmitted through real-time streaming.", "The embodiment of the present invention may combine data through the above-mentioned protocol stack, and may also provide various enhanced services, for example, an interactive service, a second screen service, etc.", "FIG.", "27 is a conceptual diagram illustrating an XML schema of a Service Type element according to an embodiment of the present invention.", "Prior to describing FIG.", "27, definition and structure of the service guide, the service fragment, and the ServiceType element according to the embodiment will be described as follows.", "The service guide may indicate a broadcast distribution channel over which Service Guide Delivery Descriptors carried within announcement sessions, can be delivered to the terminal.", "Service Guide may enable the service and content providers to describe the services and content they make available, or offer for subscription or purchase, as Mobile Broadcast services either over Broadcast Channel or over Interaction Channel.", "It may also enable the way to describe how to access the services.", "From the user perspective the Service Guide can be seen as an entry point to discover the currently available or scheduled services and content and to filter those based on their preferences.", "Furthermore, the Service Guide may provide the entry point to interactive services.", "The Service Guide may include data model that models the services, schedules, content, related purchase and provisioning data, access and interactivity data and so on in terms of Service Guide fragments.", "An embodiment of the invention may provide methods for initial discovery of Service Guide and the declaration of Service Guide fragments through Service Guide Delivery Descriptors that are sent over Service Guide Announcement Channel.", "An embodiment of the invention may provide delivery methods specified for Service Guide fragment delivery over Service Guide Delivery Channel, both over the Broadcast Channel as well as over the Interactive Channel.", "To manage the Service Guide data, an embodiment of the invention may provide update and management methods.", "An embodiment of the invention may provide the relevant backend interfaces for Service Guide.", "The ‘Service’ fragment may describe the content items which comprise a broadcast service, at an aggregate level.", "Depending on the type of the service, it may have interactive part(s), broadcastonly part(s), or both.", "The service fragment may include components not directly related to the content but to the functionality of the service such as purchasing or subscription information.", "In accordance with one embodiment of the present invention, as the part of the Service Guide, the ‘Service’ fragment may form a central hub referenced by the other fragments.", "Together with the associated fragments, the terminal may determine the details associated with the service at any point of time.", "These details may be summarized into a user-friendly display, for example, of what, how and when the associated content may be consumed and at what cost.", "A service may represent a bundle of content items, which forms a logical group to the end-user.", "An example would be a TV channel, composed of several TV shows.", "A ‘Service’ fragment contains the metadata describing the Mobile Broadcast service.", "ServiceType element may indicate the type of a service written in the corresponding service fragment.", "The mixed service types may be indicated by the presence of multiple instances of ServiceType.", "This element may be processed by the terminal strictly for rendering to the user for example as a textual indicator, an icon, or graphic representation for the service.", "The embodiments of the present invention provide a method for representing a service type used in a hybrid broadcast system.", "In addition, according to the embodiment, the range of ServiceType values to be shown in the hybrid broadcast system may be allocated to the ServiceTypeRangeType value.", "The values allocated to the Service Type fragment according to the embodiment are as follows.", "If the Service Type value is set to zero ‘0’, this means “Unspecified”.", "If the Service Type value is set to 1, this means that the corresponding service is Basic TV.", "If the Service Type value is set to 2, this means that the corresponding service is Basic Radio.", "If the Service Type value is set to 3, this means that the corresponding service is a Rights Issuer Service.", "If the Service Type value is set to 4, this means ‘Cachecast’.", "If the Service Type value is set to 5, this means ‘File download services’.", "If the Service Type value is set to 6, this means ‘Software management services’.", "If the Service Type value is set to 7, this means ‘Notification’.", "If the Service Type value is set to 8, this means ‘Service Guide’.", "If the Service Type value is set to 9, this means ‘Terminal Provisioning services’.", "If the Service Type value is set to 10, this means ‘Auxiliary Data’.", "If the Service Type value is set to 11, this means ‘Streaming on demand’.", "If the Service Type value is set to 12, this means ‘File download on demand’.", "If the Service Type value is set to 14, this means ‘Linear service’.", "If the Service Type value is set to 15, this means ‘AppBased service’.", "If the Service Type value is set to 16, this means ‘Companion Screen service’.", "The remaining values other than the above-mentioned values may also be used to represent other services other than the above-mentioned services.", "Referring to FIG.", "27, the ServiceType element according to the embodiment may have the value of ServiceTypeRangeType.", "ServiceTypeRangeType may include ServiceTypeLRType, ServiceTypeOtherEnablersRangeType, and/or ServiceTypeProprietaryRangeType.", "In this case, ServiceTypeLRType may have a minimum value of 0, and may have any one of 13, 14, 15, 16 or higher as a maximum value.", "FIG.", "28 illustrates an XML schema regarding a specific service having a service type value of 14, and an exemplary display image thereof according to an embodiment of the present invention.", "Referring to FIG.", "28, the Service fragment may be entitled ‘Home and Shopping’, and may have the ServiceType value of 14.(L28010).", "The ServiceType value of 14 may represent a Linear Service.", "In this case, the reception apparatus according to the embodiment can recognize that scheduling information of the service guide is contained in the screen when the selected service type is set to Linear Service (value=14).", "In addition, the embodiment of the present invention can provide the user with broadcast program schedule information by combining the corresponding service with schedule information.", "(L28020).", "In addition, if the service type is signaled in the service fragment, the receiver has only to combine the above-mentioned schedule information with the service including time information.", "Therefore, the embodiment of the present invention can improve throughput or performance of the receiver.", "FIG.", "29 illustrates an XML schema regarding a specific service having service type values 14 and 15, and an exemplary display image thereof according to an embodiment of the present invention.", "Service Fragment according to the embodiment may be entitled ‘MBC’, and may have the Service Type values 14 and 15.(L29010).", "The ServiceType value of 15 may indicate ‘AppBased service’.", "If the AppBased service type is signaled in the service fragment, the reception apparatus according to the embodiment can recognize that the AppBased Service is contained in the corresponding service.", "(L29020).", "Therefore, although the embodiment has obtained only the Service fragment, it may inform the user that the associated App can be executed through the ServiceType in L29030.As shown in FIG.", "29, since the service entitled ‘MBC’ also includes the ServiceType value 14, the effects of the present invention may also be achieved when the corresponding service is Linear Service (value=14), and associated description has already been disclosed above.", "FIG.", "30 illustrates an XML schema regarding a specific service having service type values 14 and 16, and an exemplary display image thereof according to an embodiment of the present invention.", "Referring to FIG.", "30, the Service fragment may be entitled ‘MBC Companion Screen’, and may have the ServiceType values (14, 16).", "(L30010).", "The ServiceType value 16 may indicate a Companion Screen service.", "If the Companion Screen service type is signaled in the service fragment, the reception apparatus according to the embodiment can recognize that the Companion Screen service is contained in the corresponding service.", "(L30020).", "Therefore, although the embodiment has obtained only the Service fragment, it may inform the user of the presence of services supplied from the Companion Screen.", "(L30030).", "As shown in FIG.", "30, since the MBC Companion Screen service also includes the ServiceType value 14, the effects of the present invention may also be achieved when the corresponding service is Linear Service (value=14), and associated description has already been disclosed above.", "FIG.", "31 illustrates an XML schema of a Component Fragment according to an embodiment of the present invention.", "Referring to FIG.", "31, the Component fragment according to one embodiment may describe some parts of content to be referenced by the component, or may describe some parts of the service to be referenced by the component.", "(The ‘Component’ fragment describes a component that is a part of a service or a content that the component refers to).", "The Component fragment according to the embodiment may include an ‘id’ attribute, a version attribute, a validFrom attribute, a validTo attribute, a ComponentType element, a ComponentData element, and/or a PrivateExt element.", "The ‘id’ attribute may indicate an ID of the component fragment.", "This attribute value may be globally unique.", "The version attribute may indicate version information of the component fragment.", "The validFrom attribute may indicate an initial time at which the component fragment is valid.", "The validTo attribute may denote the last time at which the component fragment is valid.", "The ComponentType element may indicate the type of content to be described by the component fragment.", "If several types are mixed, the ComponentType may indicate the type using one or more ComponentType elements.", "The ComponentData element may indicate Component Content contained in the component fragment.", "This element may indicate video, audio or CC (Closed Caption) data.", "The PrivateExt element may indicate a container for proprietary or application-specified extension.", "(The PrivateExt element may serve as a container for proprietary or application specific extensions).", "FIG.", "32 illustrates an XML schema of a ComponentType element according to an embodiment of the present invention.", "Referring to FIG.", "32, the component may indicate all ComponentType information capable of being transmitted through hybrid broadcasting.", "For this purpose, the embodiment of the present invention may indicate the range of type as an integer value.", "In accordance with the embodiment, not all the components include data (ComponentData), such that the reception apparatus can first recognize the type value of the component fragment, and then recognize information regarding component data.", "The relationship between subordinates and superiors of the components or the subordinate relationship of the respective components will hereinafter be given.", "In accordance with the embodiment, the ComponentRangeType indicating the ComponentType element type may be set to zero as a minimum value, and may be set to 13 as a maximum value.", "As shown in FIG.", "32, if the ComponentType element value is set to zero, this means ‘Unspecified’.", "If the ComponentType element value is set to 1, this means a Continuous component.", "If the ComponentType element value is set to 2, this means an Elementary component.", "If the ComponentType element value is set to 3, this means a Composite component.", "If the ComponentType element value is set to 4, this means a PickOne component.", "If the ComponentType element value is set to 5, this means a Complex component.", "If the ComponentType element value is set to 6, this means a Presentable component.", "If the ComponentType element value is set to 7, this means an NRT File.", "If the ComponentType element value is set to 8, this means an NRT Content Item.", "If the ComponentType element value is set to 9, this means an Application.", "If the ComponentType element value is set to 10, this means ‘ATSC3.0 Application’.", "If the ComponentType element value is set to 11, this means an On Demand component.", "If the ComponentType element value is set to 12, this means a Notification Stream.", "If the ComponentType element value is set to 13, this means an AppBased Enhancement.", "If the ComponentType element value is set to any one of 14 to 25, this means ‘Reserved’.", "The Continuous component may indicate a content component represented in one continuous stream.", "For example, the Continuous component may correspond to Audio, Video, or Closed Caption.", "The Elementary component may indicate a Continuous component corresponding to single encoding.", "That is, the Elementary component may indicate a Continuous component encoded by a separate encoder.", "For example, single encoding of the sound sequence, single encoding of the picture sequence, or the single closed caption track may correspond to the Elementary component.", "The Composite component may indicate a content component constructing the set of continuous components which have the same content type, represent the same scene, and can be combined to construct one presentation.", "For example, the Composite component may be implemented as music, dialogue, and sound effect, which are to be mixed to provide high-quality audio.", "In addition, a left-eye image and a right-eye image to be combined to construct a three dimensional (3D) image may also correspond to the composite component.", "The PickOne component may indicate a content component constructing the set of continuous components capable of being selected to have the same content type, display the same scene, and construct one presentation.", "For example, the set of audio components encoded by bit rates different from those of the same sound sequence, the set of video components encoded by bit rates different from those of the same picture sequence, or the set of general closed caption tracks and easy reader closed caption tracks for the same dialogue may correspond to the PickOne component.", "The Complex component may indicate the Composite component or the PickOne component.", "The Presentable component may denote the Continuous component displayed for the user.", "This component may include the Elementary component or Complex component.", "The NRT File may indicate a non-realtime transmission file.", "The NRT Content Item may indicate the set of one or more NRT files to be package-consumed by users who will purchase the set of NRT files.", "The Application may indicate the set of constituent documents of the complete enhanced or interactive service.", "The above-mentioned documents may include HTML, JavaScript, CSS, XML, and/or multimedia files.", "The Application may access other data instead of the part of the application.", "This Application may correspond to a special case of NRT Content Item.", "The ATSC3.0 Application may indicate Application based on ATSC 3.0 Application Runtime Environment Specification.", "The On Demand component may indicate a content component transmitted on demand.", "The Notification Stream may indicate a stream capable of transmitting a notification message configured to synchronize actions of the application under Linear Time Base.", "The AppBased Enhancement may include zero or more Notification Streams to transmit synchronized notification of the actions, one or more applications, zero or more different NRT Content Items used by the application, and zero or more On Demand components managed by the application.", "FIG.", "33 illustrates an XML schema of a ComponentData element according to an embodiment of the present invention.", "Referring to FIG.", "33, the embodiment of the present invention may define the ComponentData element as the schema so as to direct or guide characteristics of the actual Component Data.", "The ComponentData element according to the embodiment may represent the Component Data according to the combination or relationship between respective types, when the ComponentType element value of the above-mentioned component fragment is set to 2, 3, 4 or 6.In accordance with the embodiment, each component may have the ContentType attribute.", "The ContentType attribute may have Video, Audio, and/or CC (Closed Caption) values.", "As can be seen from the schema of FIG.", "33, the embodiment of the present invention can provide a method for describing the Component Data according to each ContentType attribute.", "That is, the ComponentData element according to the embodiment may have the VideoComponent element as a lower element, when the ContentType attribute value is denoted by ‘Video’.", "If the ContentType attribute value is denoted by ‘Audio’, the AudioComponent element may be used as a lower element.", "If the ContentType attribute value is denoted by CC, the CCComponent element may be used as a lower element.", "In addition, each Component Data may be described (or written) in the lower element.", "FIG.", "34 illustrates an XML schema of a VideoComponent element and a VideoRole element according to an embodiment of the present invention.", "The embodiment of the present invention can provide a method for describing a Video Component used in hybrid broadcasting.", "The VideoComponent element according to the embodiment may include a VideoRole element, a TargetUserProfile element, and/or a TargetDevice element as lower elements.", "(L34010).", "The VideoRole element may indicate the role of the corresponding Video Component.", "In accordance with the embodiment, the VideoRole element may have an integer value in consideration of future extensibility.", "In addition, this embodiment can provide the range of the above VideoRole element in such a manner that not only the role achieved when the Video Component is denoted by ‘presentable’, but also the other role achieved when the Video Component is denoted by ‘composite’ can be displayed.", "The TargetUserProfile element and the TargetDevice element may correspond to the common element of all the presentable components.", "These elements may indicate attributes of the target.", "If the VideoRole element according to the embodiment is denoted by 0, this means ‘Unspecified’.", "If the VideoRole element is denoted by 1, this means ‘Primary (default) video’.", "If the VideoRole element is denoted by 2, this means ‘Alternative camera view’.", "If the VideoRole element is denoted by 3, this means ‘Other alternative video component’.", "If the VideoRole element is denoted by 4, this means ‘Sign language (e.g., ASL) inset’.", "If the VideoRole element is denoted by 5, this means ‘Follow subject video’.", "If the VideoRole element is denoted by 6, this means ‘Base layer for scalable video encoding’.", "If the VideoRole element is denoted by 7, this means ‘Enhancement layer for scalable video encoding with level’.", "If the VideoRole element is denoted by 8, this means ‘3D video left view’.", "If the VideoRole element is denoted by 9, this means ‘3D video right view’.", "If the VideoRole element is denoted by 10, this means ‘3D video depth information’.", "If the VideoRole element is denoted by 11, this means ‘Part of video array, <x,y> of <n,m>.", "If the VideoRole element is denoted by 12, this means ‘FollowSubject metadata’.", "If the VideoRole element is denoted by 13˜25, this means ‘Reserved’.", "If the VideoRole element is denoted by 0˜5, this means the role of Presentable Video Component.", "If the VideoRole element is denoted by 6˜12, this means the role of Composite Video Component.", "If the VideoRole element is denoted by 13˜255, this means the role of ‘Other Video Component’.", "(L34020) FIG.", "35 illustrates an XML schema of an AudioComponent element and an AudioRole element according to an embodiment of the present invention.", "The embodiment of the present invention can provide a method for describing Audio Component used in hybrid broadcasting.", "The AudioComponent element according to the embodiment may have the associatedTo attribute and/or the NumberOfAudioChannels attribute.", "The AudioComponent element may have the AudioRole element, the TargetUserProfile element, and/or the TargetDevice element as lower elements.", "(L35010) The associatedTo attribute may indicate whether the corresponding Audio Component is associated with the Presentable Video Component.", "This attribute may have an id value of the component fragment.", "The NumberOfAudioChannels attribute may indicate the number of Audio Component channels.", "The AudioRole element may indicate the role of the corresponding Audio Component.", "In accordance with the embodiment, the AudioRole element may have an integer value in consideration of future extensibility.", "The TargetUserProfile and the TargetDevice element may correspond to the common element of all the presentable components.", "These elements may represent target attributes.", "The AudioRole element according to the embodiment may have the values of 0˜7.If the AudioRole element is set to zero ‘0’, this means ‘Unspecified’.", "If the AudioRole element is set to 1, this means ‘Complete main’.", "If the AudioRole element is set to 2, this means ‘Music’.", "If the AudioRole element is set to 3, this means ‘Dialog’.", "If the AudioRole element is set to 4, this means ‘Effects’.", "If the AudioRole element is set to 5, this means ‘Visually impaired’.", "If the AudioRole element is set to 6, this means ‘Hearing impaired’.", "If the AudioRole element is set to 7, this means ‘Commentary’.", "If the AudioRole element is set to the values of 8 to 255, this means ‘Reserved’.", "(L35020) FIG.", "36 illustrates an XML schema of a CCComponent element and a CCRole element according to an embodiment of the present invention.", "Referring to FIG.", "36, the embodiment can provide a method for describing a CC Component used in hybrid broadcasting.", "The CCComponent element according to the embodiment may have an associatedTo attribute, a CCRole element, a TargetUserProfile element, and/or a TargetDevice element as lower elements.", "(L36010) The associatedTo attribute may indicate whether the corresponding CC Component is associated with the Presentable Video Component.", "The associatedTo attribute may have an ‘id’ value of the component fragment.", "The associatedTo attribute may indicate the role of the corresponding CC Component.", "In accordance with the embodiment, the associatedTo attribute may have an integer value in consideration of the future extensibility.", "The TargetUserProfile element and the TargetDevice element may correspond to the common element of all the presentable components.", "The TargetUserProfile and TargetDevice elements may indicate target attributes.", "The CCRole element according to the embodiment may have the values of 0 to 2.If the CCRole element is set to zero (0), this means ‘unspecified’.", "If the CCRole element is set to 1, this means ‘normal’.", "If the CCRole element is set to 2, this means the easy reader.", "(L36020) FIG.", "37 illustrates an XML schema of component fragments regarding a Composite Video Component including one base layer and two enhancement layers in scalable video coding according to an embodiment of the present invention.", "In accordance with this embodiment, the component fragment (L37010) located at the top of FIG.", "37 may have the ID value “bcast://lge.com/Component/1”, and may indicate that the corresponding component is any of the Continuous and Composite components using the ComponentType element.", "The Component fragment (L37020) located to the left of FIG.", "37 may have “bcast://lge.com/Component/2” as the ID value, and may indicate that the corresponding component is any of the Continuous and Elementary components using the ComponentType element.", "In addition, the Component fragment (L37020) may indicate that the corresponding component relates to the Video component using the ComponentData element, the ContentType attribute, the VideoComponent element, and the VideoRole element, and may indicate that the corresponding element is a “Base Layer of SVC” component.", "The Component fragment (L37030) located to the right of FIG.", "37 may have “bcast://lge.com/Component/3” as the ID value, and may indicate that the corresponding component is any of the Continuous and Elementary components using the ComponentType element.", "In addition, the Component fragment (L37030) may indicate that the corresponding component relates to the Video component using the ComponentData element, the ContentType attribute, the VideoComponent element, and the VideoRole element, and may indicate that the corresponding element is an “Enhancement Layer of SVC” component.", "FIG.", "38 illustrates an XML schema of component fragments regarding a Composite Component including a 3D video left view and a 3D video right view according to an embodiment of the present invention.", "In accordance with the embodiment, the Component fragment (L38010) located to the top of FIG.", "38 may have “bcast://lge.com/Component/1” as the ID value, and may indicate that the corresponding component is any of the Continuous and Composite components using the ComponentType element.", "The Component fragment (L38020) located to the left of FIG.", "38 may have “bcast://lge.com/Component/2” as the ID value, and may indicate that the corresponding component is any of the Continuous and PickOne components using the ComponentType element.", "In addition, the Component fragment (L38020) may indicate that the corresponding component relates to the Video component using the ComponentData element, the ContentType attribute, the VideoComponent element, and the VideoRole element, and may indicate that the corresponding element is a “3D video left view” component.", "The Component fragment (L38030) located to the right of FIG.", "38 may have “bcast://lge.com/Component/3” as the ID value, and may indicate that the corresponding component is any of the Continuous and PickOne components using the ComponentType element.", "In addition, the Component fragment (L38030) may indicate that the corresponding component relates to the Video component using the ComponentData element, the ContentType attribute, the VideoComponent element, and the VideoRole element, and may indicate that the corresponding element is a “3D video right view” component.", "FIG.", "39 illustrates an XML schema of component fragments configured to describe a Complete Audio Component according to an embodiment of the present invention.", "In accordance with the embodiment, the Component fragment (L39010) located at the uppermost part of FIG.", "39 may have “bcast://lge.com/Component/1” as the ID value, and may indicate that the corresponding component is any of the Continuous and PickOne components using the ComponentType element.", "The Component fragment (L39020) located to the left side of the second column of FIG.", "39 may have “bcast://lge.com/Component/2” as the ID value, and may indicate that the corresponding component is any of the Continuous and PickOne components using the ComponentType element.", "In addition, the Component fragment (L39020) may indicate that the corresponding component relates to the Audio component using the ComponentData element, the ContentType attribute, the AudioComponent element, and the AudioRole element, and may indicate that the corresponding element is a Completely Main component.", "The Component fragment (L39030) located to the right part of the second column of FIG.", "39 may have “bcast://lge.com/Component/3” as the ID value, and may indicate that the corresponding component is any of the Continuous and Composite components using the ComponentType element.", "The Component fragment (L39040) located to the left side of the third column of FIG.", "39 may have “bcast://lge.com/Component/4” as the ID value, and may indicate that the corresponding component is any of the Continuous and PickOne components using the ComponentType element.", "In addition, the Component fragment (L39040) may indicate that the corresponding component relates to the Audio component using the ComponentData element, the ContentType attribute, the AudioComponent element, and the AudioRole element, and may indicate that the corresponding element is a Music component.", "The Component fragment (L39050) located to the right side of the third column of FIG.", "39 may have “bcast://lge.com/Component/5” as the ID value, and may indicate that the corresponding component is any of the Continuous and PickOne components using the ComponentType element.", "In addition, the Component fragment (L39050) may indicate that the corresponding component relates to the Audio component using the ComponentData element, the ContentType attribute, the AudioComponent element, and the AudioRole element, and may indicate that the corresponding element is a Dialogue component.", "FIG.", "40 illustrates an XML schema of a component element contained in a content fragment according to an embodiment of the present invention.", "Referring to FIG.", "40, the component contained in the content may be constructed as the sub-element.", "The Component element may be contained in the Content fragment.", "In this case, the sub-element may have the same meaning as the lower element.", "The Component element according to one embodiment may indicate component information contained in the content.", "The Component element type according to one embodiment may be denoted by ComponentElementType.", "The ComponentElementType may define component information contained in the content in the form of a sequence.", "Therefore, all types of components contained in the content may be written in the ComponentElementType.", "The Component element according to one embodiment may have a VideoData element, an AudioData element, and/or a CCData element as the sub-elements.", "In addition, the VideoData element may have a VideoRole element, a TargetUserProfile element, and/or a TargetDevice element as the sub-elements.", "The AudioData element may have an AudioRole element, a TargetUserProfile element, and/or a TargetDevice element as the sub-elements.", "The CCData element may have a CCRole element, a TargetUserProfile element, and/or a TargetDevice element as the sub-elements.", "Detailed description of the above-mentioned elements has already been disclosed above.", "FIG.", "41 illustrates an XML schema of a content fragment regarding a Linear Service including Video, Audio, and CC Components according to an embodiment of the present invention.", "Referring to FIG.", "41, assuming that the Component element is constructed in the content fragment according to one embodiment, the Reference rules between the plurality of Components need not be used, resulting in increased efficiency.", "Therefore, assuming that the receiver according to one embodiment receives the content fragment, it can be recognized which component is used as the constituent element of the corresponding content, and it may be possible to intuitively recognize the role of the recognized component.", "In accordance with the embodiment, the Component element may be defined in the PrivateExt element contained in the Content fragment.", "Referring to the left side of FIG.", "41 and the schema thereof, the 2D tennis broadcast content may include Video, Audio and CC components.", "The Video component may indicate a Primary (default) video.", "The Audio component may indicate a Complete main.", "The CC component may indicate a normal.", "Referring to the right side of FIG.", "41 and the schema thereof, the 3D tennis broadcast content may include 2 Video components, the Audio component, and a CC component.", "The first Video component of the 3D tennis broadcast content may indicate a 3D video left view.", "The second Video component may indicate a 3D video right view.", "The Audio component may indicate a Complete main.", "The CC component may indicate a normal.", "FIG.", "42 illustrates an XML schema of a component element when the component element is defined in the content fragment so as to describe the association relationship among Video, Audio, and CC components.", "In accordance with the embodiment, it may be necessary to define the association relationship between constituent components of the single content.", "In accordance with the embodiment, assuming that the Component element is constructed in the Content fragment, all the components (i.e., Video, Audio and/or CC components) contained in the corresponding content are described in the Content fragment, such that the association relationship between the components need not be independently described.", "FIG.", "43 is a conceptual diagram illustrating an exemplary case in which AssociatedTo attributes are used to describe the association relationship among Video, Audio, and CC components.", "In accordance with one embodiment of the present invention, the associatedTo attribute may be described as the Audio and CC component attributes so as to describe the association relationship between Presentable Video, Audio and CC Components.", "As a result, if the receiver according to one embodiment receives the Audio component, the receiver may recognize the Video component associated with the received Audio component.", "Likewise, if the receiver receives the CC component, the receiver may recognize the Video component associated with the received CC component.", "Referring to FIG.", "43, the embodiment of the present invention may define the associatedTo attribute as the attribute of the AudioComponent element located below the ComponentData element, and may define the associatedTo attribute as the attribute of the CCComponent element.", "FIG.", "44 is a conceptual diagram illustrating an exemplary case in which associatedAudio and associatedCC attributes are used to describe the association relationship among Video, Audio, and CC components.", "In order to define the association relationship between Presentable Video, Audio and CC Components, the associatedAudio and associatedCC attributes may be described (or written) as the Video component.", "As a result, if the receiver according to one embodiment receives the Video component, the receiver may recognize all the Audio and/or CC components associated with the received Video component.", "Referring to FIG.", "44, the embodiment of the present invention may define the associatedAudio and/or associatedCC attributes as the attribute of the VideoComponent element located below the ComponentData element, and may define the associatedAudio and/or associatedCC attributes as the attribute of the VideoComponent element.", "FIG.", "45 is a conceptual diagram illustrating the association relationship among Video, Audio, and CC components using AssociatedTo attributes.", "Referring to FIG.", "45, the associatedTo attribute is defined in the AudioComponent element in the Component fragment describing the Presentable Audio Component, and refers to “bcast://lge.com/Component/1”, such that the Component fragment describing the Presentable Video Component associated with the corresponding Presentable Audio Component may be signaled.", "In accordance with the embodiment, the associatedTo attribute is defined in the CCComponent element in the Component fragment describing the Presentable CC Component, and refers to “bcast://lge.com/Component/1”, such that the Component fragment describing the Presentable Video Component associated with the corresponding Presentable CC Component may be signaled.", "FIG.", "46 is a conceptual diagram illustrating the association relationship among Video, Audio, and CC components using associatedAudio and/or associatedCC attributes.", "In accordance with the embodiment, the associatedAudio attribute and the associatedCC attribute are defined in the VideoComponent element in the Component fragment describing the Presentable Video Component, and respectively refers to “bcast://lge.com/Component/2” and “bcast://lge.com/Component/3”, such that the Component fragments describing not only the Presentable Audio component associated with the corresponding Presentable Video Component but also the Presentable CC Component may be signaled.", "FIG.", "47 is a conceptual diagram illustrating the reference relationship between fragments according to an embodiment of the present invention.", "In accordance with one embodiment, the method for defining Service, Content, and Component fragments to provide the service guide of the next-generation broadcast system has been disclosed.", "The relationship between the above-mentioned fragments is defined, such that the embodiment of the present invention can provide a method for performing announcement of the service guide for use in the next generation hybrid broadcast system.", "In accordance with the embodiment, the Component fragment may refer to the Service fragment and/or the Content fragment.", "Referring to FIG.", "47, the Component fragment may refer to the Service fragment and the Content fragment.", "The Component fragment may refer to the Service fragment.", "The Schedule fragment may refer to the Service, Content, and Component fragments.", "FIG.", "48 illustrates an XML schema of a Component fragment including an element indicating the reference relationship between fragments according to an embodiment of the present invention.", "Referring to FIG.", "48, the Component fragment may refer to the ServiceReference element, the ContentReference element, and/or the ComponentReference element.", "Each of the above-mentioned elements may have the idRef attribute indicating each ID.", "The ServiceReference element may represent the Service fragment in the corresponding Component fragment, and may have the ID value of the referenced Service fragment.", "The ContentReference element may represent the Content fragment referenced by the corresponding Component fragment, and may have an ID value of the referenced Content fragment.", "The ComponentReference element may represent a higher Component fragment referenced by the corresponding Component fragment, and may have an ID value of the referenced higher Component fragment.", "In this case, the cross-reference relationship between the Component fragments or the relationship between subordinates and superiors between the Component fragments may be established according to classification of type values denoted by the above-mentioned ComponentType elements.", "FIG.", "49 illustrates an XML schema of a Schedule fragment including an element indicating the reference relationship between fragments according to an embodiment of the present invention.", "Referring to FIG.", "49, the Schedule fragment according to one embodiment may include the ServiceReference element, the ContentReference element, and/or the ComponentReference element.", "Each of the above-mentioned elements may have the idRef attribute indicating each ID.", "The ServiceReference element may represent the referenced Service fragment, and may have an ID value of the referenced Service fragment.", "As a result, the Schedule fragment may provide time information of the corresponding service.", "The ContentReference element may indicate the referenced Content fragment, and may have the ID value of the referenced Content fragment.", "As a result, the Schedule fragment may provide time information of the corresponding Content.", "The ComponentReference element may indicate the referenced Component fragment, and may have the ID value of the referenced Component fragment.", "As a result, the Schedule fragment may provide time information of the corresponding Component.", "FIG.", "50 illustrates the reference relationship among Service, Content, and Component fragments according to an embodiment of the present invention.", "Referring to FIG.", "50, the Component fragment describing the Presentable Audio Component and the Component fragment describing the Presentable CC Component may refer to the other Component fragment describing the Presentable Video Component using the associatedTo attribute.", "In addition, the Component fragment describing the Presentable Audio Component, the Component fragment describing the Presentable CC Component, and the Component fragment describing the Presentable Video Component may refer to the Content fragment using the ContentReference element.", "Here, the Content fragment may have the ID value denoted by “bcast://lge.com/Content/1”.", "The Content fragment in which the ID value is denoted by “bcast://lge.com/Content/1” may refer to the Service fragment in which the ID value is denoted by “bcast://lge.com/Service/1”, using the ServiceReference element.", "As described above, the embodiment of the present invention defines the cross-reference relationship between the fragments, and can construct the service guide model capable of being provided from the hybrid broadcast system.", "FIG.", "51 illustrates the reference relationship among Component fragments configured to describe a Continuous Component according to an embodiment of the present invention.", "The embodiment of the present invention defines the cross-reference relationship between the component fragments, and can describe the cross-reference relationship between the Continuous Components capable of being provided from the hybrid broadcast system.", "In accordance with the embodiment of the present invention, the Continuous Component may correspond to any of various components having the ComponentType values of 1˜6 (i.e., the Continuous component, the Elementary component, the Composite component, the PickOne component, the Complex component, and/or the Presentable component).", "As can be seen from FIG.", "51, the cross-reference relationship between the above-mentioned Continuous Components can be represented.", "In accordance with one embodiment of the present invention, the Component fragment (id=“bcast://lge.com/Component/4”) describing the Second Enhancement Layer may include “bcast://lge.com/Component/3” in the ComponentReference element, such that the Component fragment (id=“bcast://lge.com/Component/4”) may refer to the Component fragment (id=“bcast://lge.com/Component/3”) describing the First Enhancement Layer.", "As described above, since the Component fragment (id=“bcast://lge.com/Component/3”) describing the First Enhancement Layer includes “bcast://lge.com/Component/2” in the ComponentReference element, the Component fragment (id=“bcast://lge.com/Component/3”) may refer to the component fragment (id=“bcast://lge.com/Component/2”) describing the Base layer.", "In this way, the Component fragment (id=“bcast://lge.com/Component/2”) describing the Base Layer includes (“bcast://lge.com/Component/1”) in the ComponentReference element, such that the Component fragment (id=″bcast://lge.com/Component/2″) may refer to the Component fragment (id=“bcast://lge.com/Component/1”) describing the Composite Component.", "FIG.", "52 illustrates the reference relationship between Component fragments configured to describe a component associated with AppBased Enhancement according to an embodiment of the present invention.", "The embodiment of the present invention defines the cross-reference relationship between the component fragments, such that it can describe the cross-reference relationship between the AppBased Enhancement associated components capable of being received from the hybrid broadcast system.", "In accordance with the embodiment, the components corresponding to the ComponentType values of 7˜13, i.e., NRT File, NRT Content Item, Application, ATSC3.0 Application, On Demand component, Notification Stream and/or AppBased Enhancement, may correspond to the AppBased Enhancement associated Components.", "As can be seen from FIG.", "52, the cross-reference relationship between the above-mentioned AppBased Enhancement associated components can be described.", "In accordance with the embodiment, the component fragment (id=“bcast://lge.com/Component/3”) describing the NRT File may include “bcast://lge.com/Component/2” in the ComponentReference element, such that the component fragment (id=“bcast://lge.com/Component/3”) may refer to the component fragment (id=“bcast://lge.com/Component/2”) describing the NRT Content Item.", "The component fragment (id=“bcast://lge.com/Component/2”) describing the NRT Content Item includes “bcast://lge.com/Component/1” in the ComponentReference element, such that the component fragment (id=“bcast://lge.com/Component/2”) may refer to the component fragment (id=“bcast://lge.com/Component/1”) describing the AppBased Enhancement.", "The component fragment (id=“bcast://lge.com/Component/5”) describing the On Demand component includes “bcast://lge.com/Component/1” in the ComponentReference element, such that the component fragment (id=“bcast://lge.com/Component/5”) may refer to the component fragment (id=“bcast://lge.com/Component/1”) describing the AppBased Enhancement.", "The component fragment (id=“bcast://lge.com/Component/4”) describing the Application includes “bcast://lge.com/Component/1” in the ComponentReference element, such that the component fragment (id=“bcast://lge.com/Component/4”) may refer to the component fragment (id=“bcast://lge.com/Component/1”) describing the AppBased Enhancement.", "FIG.", "53 illustrates functions to be used when a content fragment refers to the associated service fragment according to an embodiment of the present invention.", "When describing the Service fragment to be referenced by the Content fragment, the embodiment of the present invention can provide a service guide method for describing detailed functions supported in the hybrid broadcast network.", "The Content fragment according to the embodiment may have the ServiceReference element.", "The ServiceReference element may include the idRef attribute, the weigh attribute, and/or the relationship attribute.", "The idRef attribute may indicate the ID of the reference Service fragment.", "The weigh attribute may indicate importance or significance of the Service fragment to be referred.", "When the relationship attribute refers to the Service fragment, the relationship may indicate the relationship between the Content fragment and the Service fragment.", "Further, this attribute value may be represented by an integer value for future extensibility.", "If this attribute value is set to zero ‘0’, this means ‘unspecified’.", "If this attribute value is set to 1, this means ‘ProgramOf’.", "If this attribute value is set to 2, this means ‘ContentItemOf’.", "If this attribute value is set to 3, this means ‘OnDemandComponentOf’.", "If this attribute value is set to any of the values of 4˜255, this means ‘reserved’.", "ProgramOf may indicate that the corresponding content corresponds to the referenced service program.", "ContentltemOf may indicate that the corresponding content corresponds to ContentItem of the referenced service.", "OnDemandComponentOf may indicate that the corresponding content corresponds to OnDemandComponent of the referenced service.", "FIG.", "54 is a conceptual diagram illustrating an exemplary case in which the content fragment refers to the associated service fragment using the relationship attributes according to an embodiment of the present invention.", "When the receiver according to one embodiment of the present invention refers to the Service fragment using the relationship attribute, it may be possible to recognize the relationship between both fragments.", "Therefore, although the embodiment does not analyze the scope extending to the component level using the relationship attribute, the embodiment may recognize which attribute is assigned to the content belonging to the corresponding service, and then inform the user of the recognized attribute information using the service guide.", "Referring to FIG.", "54, a total of 3 Content fragments may refer to the Service fragment having the ID value denoted by “bcast://lge.com/Service/1” using the ServiceReference element.", "The left content fragment may have the value of 1 as the relationship attribute value, such that this means the Program of the referenced service fragment.", "The intermediate content fragment has the value of 2 as the relationship attribute value, such that ContentItem of the referenced service fragment can be indicated.", "The right content fragment has the relationship attribute value of 3, such that OnDemandComponent of the referenced service fragment can be indicated.", "FIG.", "55 is a conceptual diagram illustrating the reference relationship between fragments according to another embodiment of the present invention.", "In accordance with one embodiment, the method for defining Service, Content, and Component fragments to provide the service guide of the next-generation broadcast system has been disclosed.", "The relationship between the above-mentioned fragments is defined, such that the embodiment of the present invention can provide a method for performing announcement of the service guide for use in the next generation hybrid broadcast system.", "In accordance with the embodiment, the Service fragment may refer to the Content fragment and/or the Component fragment.", "Referring to FIG.", "55, the Service t fragment may refer to the Content fragment and the Component fragment.", "The Content fragment may refer to the Component fragment.", "The Schedule fragment may refer to the Service, Content, and Component fragments.", "The embodiment may reduce the amount of resources needed to search not only for the constituent content of a specific service but also for the component element.", "FIG.", "56 is a conceptual diagram illustrating a service fragment including not only elements indicating the reference relationship between fragments, but also a content fragment and an XML schema of the component fragment according to another embodiment of the present invention.", "Referring to FIG.", "56, the cross-reference relationship may be achieved between the respective fragments of the service guide according to the embodiment.", "The service fragment according to one embodiment may include the ContentReference element and/or the ComponentReference element.", "Each of the above-mentioned elements may have the idRef attribute indicating each ID.", "(L56010) The ContentReference element may represent the Content fragment in the corresponding Component fragment, and may have the ID value of the referenced Content fragment.", "The ContentReference element may represent the Component fragment referenced by the corresponding Service fragment, and may have an ID value of the referenced Component fragment.", "The Content fragment according to the embodiment may include the ComponentReference element.", "The ComponentReference element may have the idRef attribute indicating the ID of this element.", "(L56020) The ComponentReference element may represent the Component fragment referenced by the corresponding content fragment, and may have the ID value of the referenced component fragment.", "The Component fragment according to the embodiment may include the ComponentReference element.", "This Component fragment may have the idRef attribute indicating the ID of this element.", "(L56030) The ComponentReference element may represent a lower Component fragment referenced by the corresponding Component fragment, and may have an ID value of the referenced lower Component fragment.", "In this case, the cross-reference relationship between the Component fragments or the relationship between subordinates and superiors between the Component fragments may be established according to classification of type values denoted by the above-mentioned ComponentType elements.", "The Schedule fragment according to one embodiment may include the ServiceReference element, the ContentReference element, and/or the ComponentReference element.", "Each of the above-mentioned elements may have the idRef attribute indicating each ID.", "(not shown) The ServiceReference element may represent the referenced Service fragment, and may have an ID value of the referenced Service fragment.", "As a result, the Schedule fragment may provide time information of the corresponding service.", "ContentReference element may indicate the referenced Content fragment, and may have the ID value of the referenced Content fragment.", "As a result, the Schedule fragment may provide time information of the corresponding Content.", "The ComponentReference element may indicate the referenced Component fragment, and may have the ID value of the referenced Component fragment.", "As a result, the Schedule fragment may provide time information of the corresponding Component.", "FIG.", "57 is a conceptual diagram illustrating the reference relationship between Service, Content and Component fragments according to another embodiment of the present invention.", "Referring to FIG.", "57, the Component fragment describing the Presentable Audio Component and the Component fragment describing the Presentable CC Component may refer to the other component describing the Presentable Video Component using the associatedTo attribute.", "The Service fragment in which the ID value is denoted by “bcast://lge.com/Service/1” may refer to the Content fragment in which the ID value is denoted by “bcast://lge.com/Content/1”, using the ContentReference element.", "The Service fragment in which the ID value is denoted by “bcast://lge.com/Content/1” may refer to the Content fragment in which the ID value is denoted by “bcast://lge.com/Component/1”, using the ComponentReference element.", "As described above, the embodiment of the present invention defines the cross-reference relationship between the fragments, and can construct the service guide model capable of being provided from the hybrid broadcast system.", "The embodiment of the present invention uses the reference direction ranging from the higher layer to the lower level in the same manner as in the above-mentioned method in which the Service fragment refers to the content fragment and the Content fragment refers to the component fragment, such that the embodiment shown in FIG.", "57 can greatly reduce the amount of resources to be consumed.", "FIG.", "58 is a conceptual diagram illustrating the reference relationship between Component fragments describing a Continuous Component according to another embodiment of the present invention.", "The embodiment of the present invention defines the cross-reference relationship between the component fragments, and can describe the cross-reference relationship between the Continuous Components capable of being provided from the hybrid broadcast system.", "In accordance with the embodiment of the present invention, the Continuous Component may correspond to any of various components having the ComponentType values of 1˜6 (i.e., the Continuous component, the Elementary component, the Composite component, the PickOne component, the Complex component, and/or the Presentable component).", "As can be seen from FIG.", "58, the cross-reference relationship between the above-mentioned Continuous Components can be represented.", "In accordance with one embodiment of the present invention, the Component fragment (id=“bcast://lge.com/Component/1”) describing the Composite Component may include “bcast://lge.com/Component/2” in the ComponentReference element, such that the Component fragment (id=“bcast://lge.com/Component/1”) may refer to the Component fragment (id=“bcast://lge.com/Component/2”) describing the Base Layer.", "As described above, since the Component fragment (id=“bcast://lge.com/Component/2”) describing the Base Layer includes “bcast://lge.com/Component/2” in the ComponentReference element, the Component fragment (id=“bcast://lge.com/Component/2”) may refer to the component fragment (id=″bcast://lge.com/Component/3″) describing the First Enhancement layer.", "Likewise, the Component fragment (id=“bcast://lge.com/Component/3”) describing the First Enhancement Layer includes (“bcast://lge.com/Component/4”) in the ComponentReference element, such that the Component fragment (id=″bcast://lge.com/Component/3″) may refer to the Component fragment (id=“bcast://lge.com/Component/4”) describing the Second Enhancement Layer.", "FIG.", "59 is a conceptual diagram illustrating the reference relationship between Component fragments describing a component associated with AppBased Enhancement according to another embodiment of the present invention.", "The embodiment of the present invention defines the cross-reference relationship between the component fragments, such that it can describe the cross-reference relationship between the AppBased Enhancement associated components capable of being received from the hybrid broadcast system.", "In accordance with the embodiment, the components corresponding to the ComponentType values of 7˜13, i.e., NRT File, NRT Content Item, Application, ATSC3.0 Application, On Demand component, Notification Stream and/or AppBased Enhancement, may correspond to the AppBased Enhancement associated Components.", "As can be seen from FIG.", "59, the cross-reference relationship between the above-mentioned AppBased Enhancement associated components can be described.", "In accordance with the embodiment, the Component fragment (id=“bcast://lge.com/Component/1”) describing the AppBased Enhancement may include “bcast://lge.com/Component/2”, “bcast://lge.com/Component/4”, and “bcast://lge.com/Component/5” in the ComponentReference element, such that the Component fragment (id=“bcast://lge.com/Component/1”) may refer to the component fragment (id=“bcast://lge.com/Component/2”) describing the NRT Content Item, the component fragment (id=“bcast://lge.com/Component/4”) describing the Application, and the component fragment (id=“bcast://lge.com/Component/5”) describing the OnDemand component.", "The component fragment (id=“bcast://lge.com/Component/2”) describing the NRT Content Item includes “bcast://lge.com/Component/3” in the ComponentReference element, such that the component fragment (id=“bcast://lge.com/Component/2”) may refer to the component fragment (id=“bcast://lge.com/Component/3”) describing the NRT File.", "FIGS.", "60 and 61 illustrate the Component fragments according to an embodiment of the present invention.", "It should be noted that Table of FIG.", "60 and Table of FIG.", "61 are grouped into one table such that two tables shown in FIGS.", "60 and 61 may correspond to one table.", "The component fragment according to the embodiment may include an id attribute, a version attribute, a validFrom attribute, a validTo attribute, a ServiceReference element, a ContentReference element, ComponentReference element, a ComponentType element, a ComponentRole element, a PrivateExt element, and/or a ProprietaryElements element.", "Each of the ServiceReference element, the ContentReference element, and the ComponentReference element may include the idRef attribute.", "The above-mentioned id attribute and/or the idRef attribute may include the URI format, and the above-mentioned attribute and/or elements will hereinafter be described.", "FIG.", "62 illustrates an XML schema of a Component fragment according to another embodiment of the present invention.", "Referring to FIG.", "62, the Component fragment according to one embodiment may describe some parts of content to be referenced by the component, or may describe some parts of the service to be referenced by the component.", "(The ‘Component’ fragment describes a component that is a part of a service or a content that the component refers to.)", "The Component fragment according to the embodiment may include an id attribute, a version attribute, a validFrom attribute, a validTo attribute, a ServiceReference element, a ContentReference element, a ComponentReference element, a ComponentType element, a ComponentRole element, a PrivateExt element, and/or a ProprietaryElements element.", "The ‘id’ attribute may indicate an ID of the component fragment.", "This attribute value may be globally unique.", "The version attribute may indicate version information of the component fragment.", "The validFrom attribute may indicate an initial time at which the component fragment is valid.", "The validTo attribute may denote the last time at which the component fragment is valid.", "The ServiceReference element may refer to the service fragment including the corresponding component.", "The ContentReference element may refer to the Content fragment including the corresponding component.", "The ComponentReference element may refer to the component fragment including the corresponding component.", "The ComponentType element may indicate the content type denoted by the Component fragment.", "If the types are mixed with each other, the ComponentType element may indicate the type using one or more ComponentType element.", "The ComponentRole element may indicate the role of the corresponding component.", "In accordance with the embodiment of the present invention, if the corresponding component is set to the Presentable Video, the Composite Video, the Presentable Audio, or the Presentable CC component, the ComponentRole element may include the Component Role, and a detailed description of the ComponentRole is as follows.", "The PrivateExt element may indicate a container for proprietary or application-specified extension.", "(The PrivateExt element may serve as a container for proprietary or applicationspecific extensions).", "The ProprietaryElements element may indicate proprietary or application-specific elements.", "The ProprietaryElements element may include one or more sub-elements or one or more attributes.", "FIG.", "63 illustrates an XML schema of a ComponentType element according to another embodiment of the present invention.", "Referring to FIG.", "63, the component according to the embodiment may represent all the ComponentType elements capable of being transmitted through hybrid broadcasting.", "For this purpose, the range of the type may be represented by an integer value.", "In accordance with the embodiment, not all the components include data (ComponentData), such that the reception apparatus can first recognize the type value of the component fragment, and then recognize information regarding component data.", "The relationship between subordinates and superiors of the components or the subordinate relationship of the respective components will hereinafter be given.", "In accordance with the embodiment, the ComponentRangeType indicating the ComponentType element type may be set to zero as a minimum value, and may be set to 15 as a maximum value.", "As shown in FIG.", "63, if the ComponentType element value is set to zero, this means ‘Unspecified’.", "If the ComponentType element value is set to 1, this means a Continuous component.", "If the ComponentType element value is set to 2, this means an Elementary component.", "If the ComponentType element value is set to 3, this means a Composite component.", "If the ComponentType element value is set to 4, this means a PickOne component.", "If the ComponentType element value is set to 5, this means a Complex component.", "If the ComponentType element value is set to 6, this means a Presentable Audio component.", "If the ComponentType element value is set to 7, this means a Presentable Audio component.", "If the ComponentType element value is set to 8, this means a Presentable CC component.", "If the ComponentType element value is set to 9, this means an NRT File.", "If the ComponentType element value is set to 10, this means an NRT Content Item.", "If the ComponentType element value is set to 11, this means an Application.", "If the ComponentType element value is set to 12, this means an ATSC3.0 Application.", "If the ComponentType element value is set to 13, this means an On Demand component.", "If the ComponentType element value is set to 14, this means a Notification Stream.", "If the ComponentType element value is set to 15, this means an AppBased Enhancement.", "If the ComponentType element value is set to any one of 16 to 255, this means ‘Reserved’.", "The Continuous component may indicate a content component represented in one continuous stream.", "For example, the Continuous component may correspond to Audio, Video, or Closed Caption.", "The Elementary component may indicate a Continuous component corresponding to single encoding.", "That is, the Elementary component may indicate a Continuous component encoded by a separate encoder.", "For example, single encoding of the sound sequence, single encoding of the picture sequence, or the single closed caption track may correspond to the Elementary component.", "The Composite component may indicate a content component constructing the set of continuous components which have the same content type, represent the same scene, and can be combined to construct one presentation.", "For example, the Composite component may be implemented as music, dialogue, and sound effect, which are to be mixed to provide high-quality audio.", "In addition, a left-eye image and a right-eye image to be combined to construct a three dimensional (3D) image may also correspond to the composite component.", "The PickOne component may indicate a content component constructing the set of continuous components capable of being selected to have the same content type, display the same scene, and construct one presentation.", "For example, the set of audio components encoded by bit rates different from those of the same sound sequence, the set of video components encoded by bit rates different from those of the same picture sequence, or the set of general closed caption tracks and easy reader closed caption tracks for the same dialogue may correspond to the PickOne component.", "The Complex component may indicate the Composite component or the PickOne component.", "The Presentable component may denote the Continuous component displayed for the user.", "The Presentable component may include the Elementary component or Complex component.", "The Presentable Video component may denote the Video Continuous component displayed for the user.", "The Presentable Audio component may denote the Audio Continuous component displayed for the user.", "The Presentable CC component may denote the CC Continuous component displayed for the user.", "The NRT File may indicate a non-realtime transmission file.", "The NRT Content Item may indicate the set of one or more NRT files to be package-consumed by users who will purchase the set of NRT files.", "The Application may indicate the set of constituent documents of the complete enhanced or interactive service.", "The above-mentioned documents may include HTML, JavaScript, CSS, XML, and/or multimedia files.", "The Application may access another data instead of the part of the application.", "This Application may correspond to a special case of NRT Content Item.", "The ATSC3.0 Application may indicate Application based on ATSC 3.0 Application Runtime Environment Specification.", "The On Demand component may indicate a content component transmitted on demand.", "The Notification Stream may indicate a stream capable of transmitting a notification message configured to synchronize actions of the application under Linear Time Base.", "The AppBased Enhancement may include zero or more Notification Streams to transmit synchronized notification of the actions, one or more applications, zero or more different NRT Content Items used by the application, and zero or more On Demand components managed by the application.", "FIG.", "64 illustrates an XML schema of a ComponentRole element according to an embodiment of the present invention.", "Referring to FIG.", "64, the component may indicate the role of all the components capable of being transmitted through hybrid broadcasting.", "For this purpose, the ComponentRole element may be denoted by an integer value.", "The ComponentRole element may range from 0 to 21.The Component element ranges from 0 to 21 such that it can indicate not only the role obtained when the Component element is ‘Presentable’, but also the role obtained when the Component element is ‘Composite’.", "If the ComponentRole element according to the embodiment is denoted by 0, this means ‘Unspecified’.", "If the ComponentRole element is denoted by 1, this means ‘Primary (default) video’.", "If the ComponentRole element is denoted by 2, this means ‘Alternative camera view’.", "If the ComponentRole element is denoted by 3, this means ‘Other alternative video component’.", "If the ComponentRole element is denoted by 4, this means ‘Sign language (e.g., ASL) inset’.", "If the ComponentRole element is denoted by 5, this means ‘Follow subject video’.", "If the ComponentRole element is denoted by 6, this means ‘Base layer for scalable video encoding’.", "If the ComponentRole element is denoted by 7, this means ‘Enhancement layer for scalable video encoding with level’.", "If the ComponentRole element is denoted by 8, this means ‘3D video left view’.", "If the ComponentRole element is denoted by 9, this means ‘3D video right view’.", "If the ComponentRole element is denoted by 10, this means ‘3D video depth information’.", "If the ComponentRole element is denoted by 11, this means ‘Part of video array, <x,y> of <n,m>.", "If the ComponentRole element is denoted by 12, this means ‘FollowSubject metadata’.", "If the ComponentRole element is denoted by 13, this means ‘Complete main’.", "If the ComponentRole element is denoted by 14, this means ‘Music’.", "If the ComponentRole element is denoted by 15, this means ‘Dialogue’.", "If the ComponentRole element is denoted by 16, this means ‘Effects’.", "If the ComponentRole element is denoted by 17, this means ‘Visually impaired’.", "If the ComponentRole element is denoted by 18, this means ‘Hearing impaired’.", "If the ComponentRole element is denoted by 19, this means ‘Commentary’.", "If the ComponentRole element is denoted by 20, this means ‘Normal’.", "If the ComponentRole element is denoted by 21, this means ‘Easy reader’.", "If the ComponentRole element is denoted by 22˜255, this means ‘Reserved’.", "If the ComponentRole element is denoted by 1˜5, this means the role of a presentable Video Component.", "If the ComponentRole element is denoted by 6˜12, this means the role of a Composite Video Component.", "If the ComponentRole element is denoted by 13˜19, this means the role of a presentable Audio Component.", "If the ComponentRole element is denoted by 20˜21, this means the role of a presentable CC Component.", "FIG.", "65 illustrates an XML schema of component fragments regarding a Composite Video Component including one base layer and two enhancement layers in scalable video coding according to another embodiment of the present invention.", "In accordance with the embodiment, the Component fragment (L65010) located at the top of FIG.", "65 may have the ID value “bcast://lge.com/Component/1”, may refer to the Service1 using the ServiceReference element, may refer to the Content1 using the ContentReference element, and may indicate that the corresponding component is any of the Continuous and Composite components using the ComponentType element.", "The Component fragment (L65020) located to the left of FIG.", "65 may have “bcast://lge.com/Component/2” as the ID value, may refer to the Service1 using the ServiceReference element, may refer to the Content1 using the ContentReference element, may refer to “bcast://lge.com/Component/1” using the ComponentReference element, and may indicate that the corresponding element is Continuous, Elementary, and Base Layer of SVC components using the ComponentType element.", "The Component fragment (L65030) located to the right of FIG.", "65 may have “bcast://lge.com/Component/3” as the ID value, may refer to the Service1 using the ServiceReference element, may refer to the Content1 using the ContentReference element, may refer to “bcast://lge.com/Component/1” using the ComponentReference element, and may indicate that the corresponding element is Continuous, Elementary, and Enhancement Layer of SVC components using the ComponentType element.", "FIG.", "66 illustrates an XML schema of component fragments regarding a Composite Component including a 3D video left view and a 3D video right view according to an embodiment of the present invention.", "In accordance with the embodiment, the Component fragment (L66010) located at the top of FIG.", "66 may have the ID value “bcast://lge.com/Component/1”, may refer to the Service1 using the ServiceReference element, may refer to the Content1 using the ContentReference element, and may indicate that the corresponding component is any of the Continuous and Composite components using the ComponentType element.", "The Component fragment (L66020) located to the left of FIG.", "66 may have “bcast://lge.com/Component/2” as the ID value, may refer to the Service1 using the ServiceReference element, may refer to the Content1 using the ContentReference element, may refer to “bcast://lge.com/Component/1” using the ComponentReference element, and may indicate that the corresponding element is Continuous, PickOne, and 3D video left view components using the ComponentType element.", "The Component fragment (L66030) located to the right of FIG.", "66 may have “bcast://lge.com/Component/3” as the ID value, may refer to the Service1 using the ServiceReference element, may refer to the Content1 using the ContentReference element, may refer to “bcast://lge.com/Component/1” using the ComponentReference element, and may indicate that the corresponding element is Continuous, PickOne, and 3D video right view components using the ComponentType element.", "FIG.", "67 illustrates an XML schema of component fragments configured to describe a Complete Audio Component according to another embodiment of the present invention.", "In accordance with the embodiment, the Component fragment (L67010) located at the uppermost part of FIG.", "67 may have the ID value “bcast://lge.com/Component/1”, may refer to the Service1 using the ServiceReference element, may refer to the Content1 using the ContentReference element, and may indicate that the corresponding component is any of the Continuous and PickOne components using the ComponentType element.", "The Component fragment (L67020) located to the left side of the second column of FIG.", "67 may have “bcast://lge.com/Component/2” as the ID value, may refer to the Service1 using the ServiceReference element, may refer to the Content1 using the ContentReference element, may refer to “bcast://lge.com/Component/1” using the ComponentReference element, and may indicate that the corresponding element is Continuous, PickOne, and Audio Completely Main components using the ComponentType element.", "The Component fragment (L67030) located to the right side of the second column of FIG.", "67 may have “bcast://lge.com/Component/3” as the ID value, may refer to the Service1 using the ServiceReference element, may refer to the Content1 using the ContentReference element, may refer to “bcast://lge.com/Component/1” using the ComponentReference element, and may indicate that the corresponding element is Continuous and Composite components using the ComponentType element.", "The Component fragment (L67040) located to the left side of the third column of FIG.", "67 may have “bcast://lge.com/Component/4” as the ID value, may refer to the Service1 using the ServiceReference element, may refer to the Content1 using the ContentReference element, may refer to “bcast://lge.com/Component/3” using the ComponentReference element, and may indicate that the corresponding element is Continuous, PickOne, and Audio Music components using the ComponentType element.", "The Component fragment (L67050) located to the right side of the third column of FIG.", "67 may have “bcast://lge.com/Component/5” as the ID value, may refer to the Service1 using the ServiceReference element, may refer to the Content1 using the ContentReference element, may refer to “bcast://lge.com/Component/3” using the ComponentReference element, and may indicate that the corresponding element is Continuous, PickOne, and Audio Music components using the ComponentType element.", "FIG.", "68 is a structural view illustrating a Content fragment according to an embodiment of the present invention.", "Referring to FIG.", "68, the embodiment of the present invention can provide a method for defining the component as a lower element of the Content fragment, and announcing the defined result to the device and user.", "In accordance with the embodiment of the present invention, the component fragment is constructed separately, such that it can reduce the number of unavoidable overlapping or repeated use times of the constituent elements and/or attributes.", "In addition, the embodiment can intuitively provide the user with announcement information.", "The Content fragment according to the embodiment may include the id attribute, the version attribute, the validFrom attribute, validTo attribute, the globalContentID attribute, the emergency attribute, the baseCID attribute, the ServiceReference element, the ProtectionKeyID element, the Name element, the Description element, the StartTime element, the EndTime element, the AudioLanguage element, the TextLanguage element, the Length element, the ParentalRating element, the TargetUserProfile element, the Genre element, the Extension element, the PreviewDataReference element, the Broadcast Area element, the TermsOfUse element, and/or the PrivateExt element.", "The id attribute may indicate an ID of the Content fragment.", "The version attribute may indicate version information of the component fragment.", "The validFrom attribute may indicate an initial time at which the component fragment is valid.", "The validTo attribute may denote the last time at which the component fragment is valid.", "The globalContentID attribute may indicate the ID for identifying the content describing the corresponding content fragment.", "The emergency attribute may indicate whether the content described by the corresponding content fragment is an emergency content.", "The baseCID attribute may indicate the CID information of the service or program.", "The ServiceReference element may indicate the service referenced by the corresponding content fragment.", "The ProtectionKeyID element may indicate the Key identifier needed to access the protected content.", "The Name element may indicate the name of the corresponding content fragment.", "The Description element may indicate Description of the corresponding content fragment.", "The StartTime element may indicate the start time information of the corresponding content presentation.", "The EndTime element may indicate the end time information for presentation of the corresponding content.", "The AudioLanguage element may allow the corresponding content to be used along with the audio stream.", "In this case, the AudioLanguage element may indicate language information of the used audio.", "The TextLanguage element may allow the corresponding content of be used along with the text component.", "In this case, the TextLanguage element may indicate language information of the used text.", "The Length element may represent the duration time of the corresponding A/V content.", "The ParentalRating element may represent reference information indicating whether the corresponding content is appropriate for children.", "The TargetUserProfile element may represent information regarding the target user.", "The Genre element may represent genre information of the corresponding content.", "The Extension element may represent additional information related to the corresponding content fragment.", "The PreviewDataReference element may represent the PreviewData fragment referenced by the corresponding component fragment.", "The BroadcastArea element may represent broadcast regional information including the position information for the broadcast content.", "The TermsOfUse element may represent ‘Terms of User’ related to the corresponding fragment.", "The PrivateExt element may represent a container for proprietary or application specific extensions.", "(An element serving as a container for proprietary or application-specific extensions.)", "The PrivateExt element may include the ProprietaryElements element as the sub-element.", "The ProprietaryElements element may represent the proprietary element or the application specific element.", "The ProprietaryElements element may include one or more sub-elements or one or more attributes.", "Since the PrivateExt element of the content fragment according to one embodiment is an element having an E1 level, the component element acting as the sub-element of the PrivateExt element may correspond to the E2 level.", "In this case, the component element may correspond to the above-mentioned ProprietaryElements element.", "FIGS.", "69, 70, 71, and 72 are structural views illustrating Component elements according to an embodiment of the present invention.", "It should be noted that Tables of FIGS.", "69 to 72 are grouped into one table such that four tables shown in FIGS.", "69 to 72 may correspond to one table.", "The component element according to the embodiment may correspond to the E2-level element, and can describe detailed information of the component.", "As a result, as many component elements as the number of component may be present or absent.", "Accordingly, the above-mentioned component element may have cardinality ranging from 0 to N. The Component element according to one embodiment may include the ComponentType element, the ComponentRole element, the StartTime element, the EndTime element, the Language element, the Length element, the ParentalRating element, the DeviceCapability element, and/or the TargetDevice element, as the sub-elements.", "The ComponentType element may describe the component type.", "This ComponentType element is located below the component element, such that it may correspond to the E3 level.", "The ComponentType element is an essential element indicating the type of the component element, such that the ComponentType element may be set to 1.If the ComponentType element is set to zero, this means an unspecified component.", "If the ComponentType element is set to 1, this means a Presentable Video component.", "If the ComponentType element is set to 2, this means a Presentable Audio component.", "If the ComponentType element is set to 3, this means a Presentable CC component.", "If the ComponentType element is set to 4, this means an AppBased Enhancement element.", "If the ComponentType element is set to 2, this means an AppBased Enhancement.", "If the ComponentType element is set to the values of 5 to 22, this means a Reserved for future use.", "The ComponentRole element may be used to describe the role of each component.", "The ComponentRole element is located below the component element, such that it may correspond to an E3 level.", "Since the ComponentRole element is an essential element describing the type of the component element, it has the cardinality of 1.Each component has the role according to the above-mentioned ComponentType element type, and may have the role corresponding to the ComponentRole element value.", "If the ComponentRole element is set to zero, this means an Unspecified.", "If the ComponentRole element is set to 1, this means a Primary (default) video.", "If the ComponentRole element is set to 2, this means an Alternative camera view.", "If the ComponentRole element is set to 3, this means an Alternative video component.", "If the ComponentRole element is set to 4, this means a Sign language (e.g., ASL) inset.", "If the ComponentRole element is set to 5, this means a Follow subject video.", "If the ComponentRole element is set to 6, this means a Complete main.", "If the ComponentRole element is set to 7, this means ‘Music’.", "If the ComponentRole element is set to 8, this means ‘Dialogue’.", "If the ComponentRole element is set to 9, this means ‘Effects’.", "If the ComponentRole element is set to 10, this means ‘Visually impaired’.", "If the ComponentRole element is set to 1, this means ‘Hearing impaired’.", "If the ComponentRole element is set to 12, this means ‘Commentary’.", "If the ComponentRole element is set to 13, this means ‘Normal’.", "If the ComponentRole element is set to 14, this means an Easy reader.", "If the ComponentRole element is set to 15, this means ‘App’.", "If the ComponentRole element is set to 16, this means an NRT Content Item.", "If the ComponentRole element is set to 17, this means an On Demand component.", "If the ComponentRole element is set to 18, this means a Notification Stream.", "If the ComponentRole element is set to 19, this means a StartOver.", "If the ComponentRole element is set to 20, this means a Companion Screen.", "If the ComponentRole element is set to the values of 21 to 255, this means a Reserved for future use.", "The StartTime element may represent a start time at which the display of the corresponding component starts displaying.", "The EndTime element may represent the end time of the display operation of the corresponding component.", "The Language element may represent expression language of the corresponding component.", "The Language element may have the languageSDPTag attribute as the attribute value.", "The languageSDPTag attribute may represent a value tagged to achieve consistency of languages described in the session description.", "The Length element may represent the duration time during which displaying of the corresponding component is performed.", "The ParentalRating element may represent the rating display information of the corresponding component.", "The DeviceCapability element may represent throughput or performance information of the device configured to perform rendering of the corresponding component.", "The embodiment may provide capability information of the device configured to perform rendering of the component using the DeviceCapability element.", "The DeviceCapability element having the values of 2 to 8 may represent Video Rendering Capability information of the device.", "The DeviceCapability element having the values of 9 to 15 may represent Audio Surround Sound Capability information of the device.", "The DeviceCapability element having the value of 16 may represent the Audio Surround Sound Capability.", "The DeviceCapability element having the values of 17 to 21 may represent the Input Capability information.", "If the DeviceCapability element is set to zero ‘0’, this means an Unspecified.", "If the DeviceCapability element is set to 1, this means Broadband connection.", "If the DeviceCapability element is set to 2, this means ‘SD’.", "If the DeviceCapability element is set to 3, this means ‘HD’.", "If the DeviceCapability element is set to 4, this means ‘UHD’.", "If the DeviceCapability element is set to 5, this means ‘8K’.", "If the DeviceCapability element is set to 6, this means ‘3D video’.", "If the DeviceCapability element is set to 7, this means ‘High Dynamic Range Imaging’.", "If the DeviceCapability element is set to 8, this means ‘Wide Color Gamut’.", "If the DeviceCapability element is set to 9, this means ‘2.0 channels’.", "If the DeviceCapability element is set to 10, this means ‘2.1 channels’.", "If the DeviceCapability element is set to 11, this means ‘5.1 channels’.", "If the DeviceCapability element is set to 12, this means ‘6.1 channels’.", "If the DeviceCapability element is set to 13, this means ‘7.1 channels’.", "If the DeviceCapability element is set to 14, this means ‘22.1 channels’.", "If the DeviceCapability element is set to 15, this means 3D audio.", "If the DeviceCapability element is set to 16, this means Dialog Level adjustment.", "If the DeviceCapability element is set to 17, this means a magic remote control input.", "If the DeviceCapability element is set to 18, this means a touch screen input.", "If the DeviceCapability element is set to 19, this means a mouse input.", "If the DeviceCapability element is set to 20, this means a keyboard use.", "In this case, the above-mentioned broadband connection may indicate whether broadband connection is needed to deliver the corresponding component.", "The Video Rendering Capability information may represent Resolution, 2D, 3D and/or other rendering associated information.", "The Audio Surround Sound Capability information may represent audio channel information.", "Dialog level adjustment of the Audio Mixing/Rendering Capability information may indicate whether the audio dialogue level can be adjusted.", "The Input Capability information may indicate a broadcast program manufactured according to a specific input device.", "The ‘app rendering’ information may indicate whether the app rendering is needed.", "The TargetDevice element may represent information of the target device on which the component is displayed.", "If the TargetDevice element is set to zero, this means ‘Unspecified’.", "If the TargetDevice element is set to 1, this means ‘Primary’.", "If the TargetDevice element is set to 2, this means ‘Companion’.", "If the TargetDevice element is set to 3, this means ‘Inset on Primary Screen (“PictureinPicture”)’.", "If the TargetDevice element is set to 4, this means ‘Reserved for future use’.", "FIG.", "73 illustrates an XML schema of a Component element according to an embodiment of the present invention.", "Referring to FIG.", "73, the Component element according to one embodiment of the present invention may include, as the sub-elements, the ComponentType element, the ComponentRole element, the StartTime element, the EndTime element, the Language element, the Length element, the ParentalRating element, the DeviceCapability element, and/or the TargetDevice element.", "Detailed description of the above-mentioned elements has already been disclosed.", "FIG.", "74 illustrates an XML schema of a Language element and a ComponentType element according to an embodiment of the present invention.", "The Language element according to one embodiment may represent expression language of the corresponding component.", "The Language element may have the languageSDPTag attribute as the attribute.", "The languageSDPTag attribute may represent a specific value tagged to achieve consistency of languages described in the session description.", "(L74010) The ComponentType element according to one embodiment may be an element to describe the component type.", "The ComponentType element is located below the component element, such that it may correspond to an E3 level.", "Since the ComponentType element is an essential element to describe the type of the component element, the ComponentType element may have cardinality of 2.If the ComponentType element is set to zero, this means an Unspecified.", "If the ComponentType element is set to 1, this means a Presentable Video component.", "If the ComponentType element is set to 2, this means a Presentable Audio component.", "If the ComponentType element is set to 3, this means a Presentable CC component.", "If the ComponentType element is set to 4, this means an AppBased Enhancement.", "If the ComponentType element is set to the values of 5 to 255, this means a Reserved for future use.", "FIG.", "75 illustrates an XML schema of a ComponentRole element according to an embodiment of the present invention.", "Referring to FIG.", "75, the ComponentRole element may be an element to describe the Role of the component.", "Since the ComponentRole element is located below the component element, it may correspond to an E3 level.", "Since the ComponentRole element is an essential element to describe the type of the component element, the ComponentRole element may have cardinality of 1.Each component may have the role according to the above-mentioned ComponentType element types, and may also have the role corresponding to the ComponentRole element value.", "If the ComponentRole element is set to zero, this means an unspecified.", "If the ComponentRole element is set to 1, this means a Primary (default) video.", "If the ComponentRole element is set to 2, this means an Alternative camera view.", "If the ComponentRole element is set to 3, this means other alternative video component.", "If the ComponentRole element is set to 4, this means a Sign language (e.g., ASL) inset.", "If the ComponentRole element is set to 5, this means a Follow subject video.", "If the ComponentRole element is set to 6, this means a Complete main.", "If the ComponentRole element is set to 7, this means a Music.", "If the ComponentRole element is set to 8, this means a Dialogue.", "If the ComponentRole element is set to 9, this means Effects.", "If the ComponentRole element is set to 10, this means a Visually impaired.", "If the ComponentRole element is set to 11, this means a Hearing impaired.", "If the ComponentRole element is set to 12, this means a Commentary.", "If the ComponentRole element is set to 13, this means a Normal.", "If the ComponentRole element is set to 14, this means an Easy reader.", "If the ComponentRole element is set to 15, this means ‘App’.", "If the ComponentRole element is set to 16, this means an NRT Content Item.", "If the ComponentRole element is set to 17, this means an On Demand component.", "If the ComponentRole element is set to 18, this means a Notification Stream.", "If the ComponentRole element is set to 19, this means a StartOver.", "If the ComponentRole element is set to 20, this means a Companion Screen.", "If the ComponentRole element is set to the values of 21 to 255, this means a Reserved for future use.", "FIG.", "76 illustrates an XML schema of a DeviceCapability element and a TargetDevice element according to an embodiment of the present invention.", "Referring to FIG.", "76, the DeviceCapability element may represent throughput or performance information of the device configured to perform rendering of the corresponding component.", "The embodiment may provide capability information of the device configured to perform rendering of the component using the DeviceCapability element.", "The DeviceCapability element having the values of 2 to 8 may represent Video Rendering Capability information of the device.", "The DeviceCapability element having the values of 9 to 15 may represent Audio Surround Sound Capability information of the device.", "The DeviceCapability element having the value of 16 may represent the Audio Surround Sound Capability.", "The DeviceCapability element having the values of 17 to 21 may represent the Input Capability information.", "If the DeviceCapability element is set to zero ‘0’, this means an Unspecified.", "If the DeviceCapability element is set to 1, this means Broadband connection.", "If the DeviceCapability element is set to 2, this means ‘SD’.", "If the DeviceCapability element is set to 3, this means ‘HD’.", "If the DeviceCapability element is set to 4, this means ‘UHD’.", "If the DeviceCapability element is set to 5, this means ‘8K’.", "If the DeviceCapability element is set to 6, this means ‘3D video’.", "If the DeviceCapability element is set to 7, this means ‘High Dynamic Range Imaging’.", "If the DeviceCapability element is set to 8, this means ‘Wide Color Gamut’.", "If the DeviceCapability element is set to 9, this means ‘2.0 channels’.", "If the DeviceCapability element is set to 10, this means ‘2.1 channels’.", "If the DeviceCapability element is set to 11, this means ‘5.1 channels’.", "If the DeviceCapability element is set to 12, this means ‘6.1 channels’.", "If the DeviceCapability element is set to 13, this means ‘7.1 channels’.", "If the DeviceCapability element is set to 14, this means ‘22.1 channels’.", "If the DeviceCapability element is set to 15, this means 3D audio.", "If the DeviceCapability element is set to 16, this means Dialog Level adjustment.", "If the DeviceCapability element is set to 17, this means a magic remote control input.", "If the DeviceCapability element is set to 18, this means a touch screen input.", "If the DeviceCapability element is set to 19, this means a mouse input.", "If the DeviceCapability element is set to 20, this means a keyboard use.", "In this case, the above-mentioned broadband connection may indicate whether broadband connection is needed to deliver the corresponding component.", "The Video Rendering Capability information may represent Resolution, 2D, 3D and/or other rendering associated information.", "The Audio Surround Sound Capability information may represent audio channel information.", "Dialog level adjustment of the Audio Mixing/Rendering Capability information may indicate whether the audio dialogue level can be adjusted.", "The Input Capability information may indicate a broadcast program manufactured according to a specific input device.", "The ‘app rendering’ information may indicate whether the app rendering is needed.", "(L76010) The TargetDevice element may represent information of the target device on which the component is displayed.", "If the TargetDevice element is set to zero, this means ‘Unspecified’.", "If the TargetDevice element is set to 1, this means ‘Primary’.", "If the TargetDevice element is set to 2, this means ‘Companion’.", "If the TargetDevice element is set to 3, this means ‘Inset on Primary Screen (“PictureinPicture”)’.", "If the TargetDevice element is set to 4, this means ‘Reserved for future use’.", "(L76020) FIG.", "77 illustrates an XML schema of a Component element when a Presentable Video Component (2D/HD) and a Presentable Audio Component (5.1 channels) are transmitted.", "Referring to FIG.", "77, according to one embodiment, if the Presentable Video Component (2D/HD) and presentable Audio Component (5.1 channels) are transmitted, the announcement function may use two Component elements as the sub-element of the PrivateExt element contained in the Content fragment.", "(L77010) The component element for the Presentable Video Component (2D/HD) may have the value of 1 (i.e., Video) as the ComponentType element value, may have the value of 1 (i.e., Primary Video) as the ComponentRole element value, may have the value of 3 (i.e., HD) as the DeviceCapability element value, and may have the value of 1 (i.e., Primary Device) as the TargetDevice element value.", "(L77010) The component element for the Presentable Audio Component (5.1 channels) may have the value of 2 (i.e., Audio) as the ComponentType element value, may have the value of 6 (i.e., Completely Main) as the ComponentRole element value, may have KOR (i.e., Korean) as the Language element value, may have the value of 11 (i.e., 5.1 channels) as the DeviceCapability element value, and may have the value of 1 (i.e., Primary Device) as the TargetDevice element value.", "(L77010) The receiver (Device) according to one embodiment may acquire the DeviceCapability element value, may determine whether the corresponding function can be supported, and may provide the user with the Capability information.", "As can be seen from the upper right part of FIG.", "77, a screen image displayed on the device configured to support HD and 5.1 channels is shown as shown in FIG.", "77.In this case, the embodiment of the present invention can display specific information indicating that the corresponding device can support HD and 5.1 channels on the screen.", "(L77020) Although the lower right part of FIG.", "77 can support the HD function, it should be noted that a screen image of the device not supporting 5.1 channels may also be shown in FIG.", "77 as necessary.", "In this case, according to one embodiment, when the receiver not supporting 5.1 channels obtains the Capability information, the non-supported 5.1 channels audio information may be grayed out such that the grayout-processed result may be displayed on the screen.", "(L77030) FIG.", "78 illustrates an XML schema of a Component element when a Presentable Video component (UHD) and Presentable ENG audio component are transmitted as broadcast signals and a Presentable SPA audio component is transmitted as a broadband signal.", "Referring to FIG.", "78, according to one embodiment of the present invention, if the Presentable Video component (UHD) and the Presentable ENG audio component are transmitted through broadcast, and if the Presentable SPA audio component is transmitted through broadband, the announcement function may use three Components as the sub-element of the PrivateExt element contained in the Content fragment.", "(L78010) The component element for the Presentable Video component (UHD) may have the value of 1 (i.e., Video) as the ComponentType element value, may have the value of 1 (i.e., Primary Video) as the ComponentRole element value, may have the value of 4 (i.e., UHD) as the DeviceCapability element value, and may have the value of 1 (i.e., Primary Device) as the TargetDevice element value.", "(L78010) The component element for the Presentable ENG audio component (through Broadcast) may have the value of 2 (i.e., Audio) as the ComponentType element value, may have the value of 6 (i.e., Completely Main) as the ComponentRole element value, may have ENG (English) as the Language element value, and may have the value of 1 (i.e., Primary Device) as the TargetDevice element value.", "(L78010) The component element for the Presentable SPA audio component (through Broadband) may have the value of 2 (i.e., Audio) as the ComponentType element value, may have the value of 6 (i.e., Completely Main) as the ComponentRole element value, may have SPA (Spanish) as the Language element value, and may have the value of 1 (indicating that the component is transmitted through broadcast) as the DeviceCapability element value, and may have the value of 1 (i.e., Primary Device) as the TargetDevice element value.", "(L78010) The receiver (Device) according to one embodiment obtains the DeviceCapability element value, determines whether the corresponding function can be supported, and provides the user with the Capability information.", "Assuming that the right part of FIG.", "78 does not support broadband connection, or assuming that the right part of FIG.", "78 is in a non-connection state whereas it can support broadband connection, it may be possible to display the screen displayed on the receiver (Device).", "(L78020) The receiver according to one embodiment of the present invention may recognize that the corresponding component is transmitted through broadband, when the DeviceCapability element is set to 1.In this case, the device not supporting broadband connection or the other device being in a non-connection whereas it can support broadband connection can perform grayout processing of the broadband transmission component, and can display the processed result on the screen.", "In this case, the SPA audio information is grayed out and then displayed on the screen.", "(78020) FIG.", "79 illustrates an XML schema of a Component element when a Presentable Video Component (UHD/Wide Color Gamut) and a Presentable Audio Component (5.1 channels) are transmitted.", "Referring to FIG.", "79, according to one embodiment of the present invention, when the Presentable Video Component (UHD/Wide Color Gamut) and the Presentable Audio Component (5.1 channels) are transmitted, the announcement function may use two Components as the sub-element of the PrivateExt element contained in the Content fragment.", "(L79010) The component element for the Presentable Video Component (UHD/Wide Color Gamut) may have the value of 1 (Video) as the ComponentType element value, may have the values of 4 (UHD) and 8 (WCG) as the DeviceCapability element values, and may have the value of 1 (i.e., Primary Video) as the TargetDevice element value.", "(L79010) The component element for the Presentable Audio Component (5.1 channels) may have the value of 2 (i.e., Audio) as the ComponentType element value, may have the value of 6 (i.e., Completely Main) as the ComponentRole element value, may have KOR (i.e., Korean) as the Language element value, may have the value of 11 (i.e., 5.1 channels) as the DeviceCapability element value, and may have the value of 1 (i.e., Primary Device) as the TargetDevice element value.", "(L79010) The receiver (Device) according to one embodiment may acquire the DeviceCapability element value, may determine whether the corresponding function can be supported, and may provide the user with the Capability information.", "As can be seen from the upper right part of FIG.", "79, a screen image displayed on the device configured to support UHD, WCG (Wide Color Gamut) and 5.1 channels is shown as shown in FIG.", "79.In this case, the embodiment of the present invention can display specific information indicating that the corresponding device can support UHD, WCG and 5.1 channels on the screen.", "(L79020) Although the lower right part of FIG.", "79 can support UHD and 5.1 channels, it should be noted that a screen image of the device not supporting WCG may also be shown in FIG.", "79 as necessary.", "In this case, according to one embodiment, when the receiver not supporting 5.1 channels obtains the Capability information, the non-supported WCG information may be grayed out such that the grayout-processed result may be displayed on the screen.", "(L79030) FIG.", "80 illustrates a component element according to another embodiment of the present invention.", "Referring to FIG.", "80, the component element may be a root element of the component sub-element.", "The component element may start from the E3 level.", "Since the component element describes detailed content of the component, as many elements as the number of components may be described.", "In association with some components, the component element may also be omitted as necessary.", "Therefore, the component element may have cardinality of 0 .", ".", ".", "N. The component element may include the ComponentType attribute, the ComponentRole element, the Language element, and/or the EssentialCapabilities element.", "The ComponentType field may include attribute information indicating the component type.", "That is, the ComponentType field indicates the attribute indicating the component type.", "The ComponentType field is an essential element indicating the component type, such that the ComponentType field may be set to 1.The ComponentTypinfield may identify that the component corresponds to Presentable Video, Presentable Audio, Presentable CC (closed caption) and/or Presentable App according to the value thereof.", "The message shown in FIG.", "80 may include one or more fields therein.", "Each field may include unique meaning or information.", "Type information may be allocated to each field.", "The type information may have the value of ‘E’, ‘A’, ‘E1’, ‘E2’, or ‘E[n]’.", "The E value may indicate that the corresponding field relates to the element.", "The A value may indicate that the corresponding field relates to the attribute information.", "The E1 value may indicate that the corresponding field relates to the sub element.", "The sub-element may correspond to a lower element defined in the element.", "The E2 value may represent a lower sub-element of the sub-element.", "That is, the E[n] element may represent the [n1]-th lower element.", "FIG.", "81 illustrates a ComponentRol element according to an embodiment of the present invention.", "Referring to FIG.", "81, the ComponentRole element is an element to describe the role of the component.", "The ComponentRole element is defined as a lower element of the component.", "The ComponentRole element may start from the E3 level.", "The ComponentRole element may have a String value.", "The ComponentRole element value may be designated as the arbitrary valid string value decided by a broadcast station manufacturing the Announcement Data.", "The ComponentRole element value may be an extensible string value, such that it can describe all kinds of the Capability Strings without difficulty.", "The target device (e.g., receiver) may display information available for the end user (e.g., a TV viewer) using the ComponentRole element value.", "In association with the component, the ComponentRole element may include specific information providing letter-shaped information capable of being recognized by the TV viewer.", "The ComponentRole element may represent various kinds of components.", "For example, in association with the presentable video component, the ComponentRole element may include “Primary video”, “Alternative camera view”, “Other alternative video component”, “Sign language inset”, and/or “Follow subject video”.", "The ComponentRole element may represent various kinds of components.", "For example, in association with the presentable audio component, the ComponentRole element may include “Complete main”, “Music”, “Dialogue”, “Effects”, “Visually impaired”, “Hearing impaired” and/or “Commentary”.", "The ComponentRole element may represent various kinds of components.", "For example, in association with the presentable CC component, the ComponentRole element may include “Normal” and/or “Easy reader”.", "The ComponentRole element may represent various kinds of components.", "For example, in association with the Presentable App (application) component, the ComponentRole element may include “On Demand”, “Startover”, and/or “CompanionScreen”.", "FIG.", "82 illustrates an XML-formatted component element according to another embodiment of the present invention.", "Referring to FIG.", "82, the component element according to one embodiment may perform signaling of each component when the component is composed of various kinds of media, such that a viewer-desired component or a receiver-desired component can be identified in advance in the reception end.", "In addition, the role of the component can be provided in the form of letters, such that the component desired by the viewer who consumes the corresponding information may be easily recognized or selected.", "The component element according to one embodiment may be extended and then contained in the Service Guide Content Fragment pre-defined in OMA BCAST as necessary.", "FIG.", "83 is a conceptual diagram illustrating a Component element according to another embodiment of the present invention.", "Referring to FIG.", "83, the component element is a root element of the Component Sub-element.", "The component element may start from the E2 level.", "Since the component element describes detailed content of each component, as many elements as the number of components may be described.", "In association with some components, the component element may also be omitted as necessary.", "Therefore, the component element may have cardinality of 0 .", ".", ".", "N. The component element may include the Presentable VideoComponent element, the PresentableAudioComponent element, the PresentableCCComponent element, and/or the PresentableAppComponent element.", "The PresentableVideoComponent element may be an element to describe the Presentable Video Component.", "The Presentable VideoComponent element is a lower element of the component element, and may start from the E3 level.", "The Presentable VideoComponent element may have a string value, and may describe the role of the video component.", "In association with the component, the Presentable VideoComponent element may include specific information to provide letter-shaped description capable of being recognized by the TV viewer.", "The role of the component capable of being represented by the Presentable VideoComponent element may include “Primary video”, “Alternative camera view”, “Other alternative video component”, “Sign language inset”, and/or “Follow subject video”.", "The PresentableAudioComponent element may be an element to describe the Presentable Audio Component.", "The PresentableAudioComponent element acting as a lower element of the component element may start from the E3 level.", "The PresentableAudioComponent element may have the string value, and may describe the role of the audio component.", "In association with the component, the PresentableAudioComponent element may provide specific information to provide letter-shaped description capable of being recognized by the TV viewer.", "The role of the component capable of being represented by the PresentableAudioComponent element may include “Complete main”, “Music”, “Dialog”, “Effects”, “Visually impaired”, “Hearing impaired” and/or “Commentary”.", "FIG.", "84 illustrates a PresentableCCComponent element and a PresentableAppComponent element according to another embodiment of the present invention.", "Referring to FIG.", "84, the element shown in FIG.", "84 may be contained in the above-mentioned component element shown in FIG.", "83.The PresentableCCComponent element may be an element to describe the Presentable CC Component.", "The PresentableCCComponent element acting as a lower element of the component element may start from the E3 level.", "The PresentableCCComponent element may have the string value, and may describe the role of the CC component.", "In association with the component, the PresentableCCComponent element may include specific information to provide letter-shaped description capable of being recognized by the viewer.", "The component capable of being denoted by the PresentableCCComponent element may include “Normal” and/or “Easy reader”.", "The PresentableAppComponent element may be an element to describe the Presentable App Component.", "The PresentableAppComponent element acting as a lower element of the component element may start from the E3 level.", "The PresentableAppComponent element may have the string value, and may describe the role of the App Component.", "In association with the component, the PresentableAppComponent element may include specific information to provide letter-shaped description capable of being recognized by the TV viewer.", "The component capable of being denoted by the PresentableAppComponent element may include “On Demand”, “Startover”, and/or “CompanionScreen”.", "If the component element is constructed according to the embodiment of the present invention, the number of repeated use times of the constituent elements and/or attribute values needed to construct the new component fragments can be greatly reduced, and announcement information can be effectively and intuitively provided to the End User.", "FIG.", "85 illustrates an XML-formatted component element according to another embodiment of the present invention.", "Referring to FIG.", "85, if the component element according to another embodiment of the present invention is comprised of various kinds of media, the component element may perform signaling of each component type, such that a viewer-desired component or a receiver-desired component can be identified in advance in the reception end.", "In addition, the role of the component can be provided in the form of letters, such that the component desired by the viewer who consumes the corresponding information may be easily recognized or selected.", "In addition, the role of the component may be provided in the form of letters, such that the component desired by the viewer who consumes the corresponding information can be readily recognized and selected.", "In addition, according to another embodiment of the present invention, the component element may be constructed in different ways according to component types, and may describe the role of each component using the string, resulting in acquisition of the extensibility.", "The component element according to one embodiment may also be extended in the Service Guide Content Fragment pre-defined in OMA BCAST as necessary.", "FIG.", "86 illustrates Essential Capabilities elements according to an embodiment of the present invention.", "Referring to FIG.", "86, according to one embodiment of the present invention, the component element may include the Capability item.", "The Capability item may correspond to specific information indicating the receiver throughput needed when the receiver can properly decode the corresponding component.", "The Capability item may be comprised of the combination of the Capability code and the String.", "The embodiment of the present invention may provide a method for additionally defining a new value in the Capability code and Capability category.", "Referring to FIG.", "86, the Capability item may be defined as a lower element of the component element.", "The Capability item may include the EssentialCapabilities element, the CapabilityCodes element, the CapabilityString element, and/or the Category attribute information.", "The EssentialCapabilities element may describe the capability required for the meaningful presentation of the service (Media, Broadcast Service).", "The EssentialCapabilities element may include the CapabilityCodes element and/or the CapablityString element.", "The EssentialCapabilities element may be defined as a lower element of the component element, and may start from the E3 level.", "The CapabilityCodes element may have the value regarding the code identifying the capability category.", "The CapabilityCodes element may indicate one or more capabilities.", "The Capability String element may include a string to describe the capability.", "The CapabilityString element may include information to describe the capability using letters.", "The CapabilityString element may include Category attribute information.", "The Category attribute information may indicate category of the capability described by the Capability String element.", "FIG.", "87 illustrates the meaning of Capability in response to a CapabilityCode element value according to an embodiment of the present invention.", "As shown in FIG.", "87, the CapabilityCode element may have different meanings according to different values thereof.", "In accordance with the embodiment, a new value is defined in the Download Protocols item, and the capability denoted by the corresponding value may be established to correspond to “IP via Broadband”.", "That is, data may be received through Broadband IP in the next generation broadcast system, and the received result may be added, as one capability type, to the Download Protocol corresponding to IP via Broadband.", "In accordance with the embodiment of the present invention, the CapabilityCode element may identify the Rendering Capability.", "In accordance with the CapabilityCode element value, the Rendering Capability requisite for the receiver may be signaled to use the component.", "The Rendering Capability denoted by the CapabilityCode element may indicate which video, audio, application, and/or CC can be rendered by the receiver.", "FIG.", "88 illustrates a Capability Category dependent upon a Category attribute information value.", "Referring to FIG.", "88, the value of the Category attribute information may be additionally defined in a manner that the capability is contained in the Rendering Capability category.", "For example, assuming that the Category attribute information is set to 0x06, this means that the capability is contained in the Rendering Capability category.", "FIG.", "89 is a conceptual diagram illustrating a method for providing a PPV (Pay Per View) program to each component according to an embodiment of the present invention.", "Referring to FIG.", "89, the PayPerView service per component may be provided.", "That is, according to one embodiment of the present invention, within one service or content, a specific component can be provided to the user through a pay per view.", "For example, according to the embodiment of the present invention, the component is defined in the announcement, such that the PayPerView service can be provided according to the component.", "For this purpose, attribute and/or element information regarding the component element may be described in the content and then transmitted.", "Each component may have pay-for-use information.", "The broadcast program (media, broadcast service, or broadcast content) may be provided free of charge, and the broadcast station may impose a predetermined charge to each component according to the quality and amount of additional information of each component of the broadcast program.", "For example, in order to allow the TV viewer to view the UHD video component but not the free-of-charge HD video component, the broadcast station may provide the TV viewer with the UHD video component through Pay Per View.", "Alternatively, the broadcast station may impose a predetermined charge to each audio component for stereoscopic sound of the Audio component.", "Alternatively, the broadcast station may impose a predetermined charge to a component requisite for the voting application configured to activate the voting broadcast program, such that the TV viewer who desires to participate in the voting must pay for the requisite component.", "The above-mentioned scheme is referred to as a Pay Per View scheme implemented by ESG transmitted per component.", "In order to establish the PPV function per component, the component element may include PPV related information in association with each component.", "Alternatively, the ComponentRole element may include PPV related information in association with each component role.", "PPV related information may include ID information for identifying whether PPV is applied to the component or the component role; PPV payment information; PPV cost information; authentication related information after completion of PPV payment; and/or duration information through which the corresponding component can be validly used after completion of PPV payment.", "Referring to FIG.", "89, according to the embodiment of the present invention, it can be recognized that PPV elements are present in the broadcast program through the ESG (Electronic Service Guide).", "The receiver may display the item of the PPV components through ESG.", "If the TV viewer selects a broadcast program having PPV elements, the receiver may indicate the presence of one or more PPV elements in the corresponding program, may display a User Interface (UI) for querying the TV viewer whether to view the PPV element, and may thus receive the selection command from the TV viewer.", "This embodiment illustrates an exemplary case in which not only basic images of the broadcast program but also additional images are present.", "If the TV viewer pays for the PPV Video Component corresponding to the Alternative View, the TV viewer can view the Alternative View images.", "In this case, the above-mentioned control unit may construct a broadcast program schedule using the PPV related information.", "The broadcast program schedule includes a specific mark indicating whether PPV is applied to a specific component.", "The above-mentioned display unit may display the broadcast program schedule thereon.", "The TV viewer may select the Alternative View images, and view the same at a later time as necessary.", "In this case, if a current display image stops displaying, the Alternative View images may be displayed.", "Alternatively, the Alternative View images may be displayed at a specific time desired by the TV viewer.", "Alternatively, the TV viewer may view in real time not only basic images provided from the main device but also the Alternative View images using the Companion Device.", "FIG.", "90 is a flowchart illustrating a method for providing media to each component of a broadcast program according to an embodiment of the present invention.", "Referring to FIG.", "90, the receiver may receive ESG (Electronic Service Guide) data through broadcast signals (J590010).", "The ESG data may include the above-mentioned elements, the Service fragment, the Content fragment, the Schedule fragment, and/or the Component Fragment.", "The receiver may parse the Service fragment, and may thus generate the list of broadcast stations to be displayed on the channel list (J590020).", "The receiver may parse the Content fragment, and may thus provide the list of broadcast programs per broadcast station (J590030).", "The receiver may parse the schedule fragment, and may thus generate a schedule of the broadcast programs per broadcast station (J590040).", "The receiver may receive a command for displaying a broadcast program schedule from the TV viewer or the user (J590050).", "The receiver may determine whether the role of the component contained in the broadcast service or the broadcast program is displayed on the ESG (J590060).", "If the role of the component contained in the broadcast service or the broadcast program is displayed on the ESG, the receiver may display detailed information of each program contained in the broadcast programs schedule (J590070).", "The receiver may obtain information regarding the component role from the above-mentioned component element and the sub-element thereof.", "The receiver may receive a selection command of a specific program or a reserved viewing command of the specific program from the TV viewer or the user (J590080).", "The receiver may enter (or decode) the broadcast programs elected by the TV viewer or the user (J590090).", "The receiver may display the Video, Audio, CC, and/or App Components on the display screen according to the role of each component contained in the broadcast program (J590100).", "The receiver may receive the command for selecting any one of the Video, Audio, CC, and/or App Components from the TV viewer or the user.", "In this case, assuming that the PPV policy for each component is present, the PPV program can be processed as described above.", "A specific message indicating the presence or absence of the PPV policy for each component may be displayed on the ESG.", "The TV viewer or the user may view the media displayed by the receiver (JS90100).", "In the meantime, if the role of component contained in the broadcast service or the broadcast program is not displayed on the ESG, the receiver may display time information of the program and/or the name of the program contained in the broadcast program schedule (JS90120).", "The receiver may receive a selection command of a specific program contained in the broadcast program schedule or the reserved viewing command of the specific program from the TV viewer or the user (JS90130).", "The receiver may enter (decode) the broadcast program selected by the TV viewer/user (JS90140).", "In the meantime, if the TV viewer or the user who views the broadcast program inputs a command for displaying the broadcast program schedule, the receiver may perform the procedures starting from the step JS90050.FIG.", "91 exemplarily illustrates screen images through which media is supplied to each component of a broadcast program according to an embodiment of the present invention.", "Referring to the step (L91010) shown in FIG.", "91, in association with the program (G) manufactured by the broadcast station (CNTV) displayed on the ESG, the role of each component is shown in FIG.", "91.If necessary, the role of each component may not be shown in FIG.", "91.For example, if the component role is displayed on the ESG, the ESG may indicate that the components capable of providing the ‘Alternative View’, ‘Follow Subject’ and ‘Sign Language’ elements are present in relation to the G program.", "Referring to the step (L91020), if the G program is displayed, the receiver may display not only ‘Sign language’ but also ‘follow subject video’ at the same time, or may display thumbnail images related to these components.", "In this case, ‘Sign language’ may correspond to sign language, and ‘follow subject video’ may correspond to images related to a current program.", "Referring to the step (L91030), assuming that the TV viewer or the user selects the ‘Alternative View’ function in relation to the G program, not only basic images of the current program but also the remaining images other than the basic images may be displayed.", "FIG.", "92 exemplarily illustrates screen images through which the role of a video component is displayed on ESG according to an embodiment of the present invention.", "The receiver receives a request of the broadcast program schedule from the TV viewer, and displays the requested broadcast program schedule.", "Information regarding the broadcast program located after the current time may be displayed on the broadcast program schedule.", "Specific information indicating that the component corresponding to a specific role related to a specific program may be displayed on the ESG.", "For example, the sing language content may be provided to the program (B).", "Therefore, the TV viewer who desires to view the sign language content may select a broadcast program in which the letters ‘sign language’ are displayed, may perform channel switching of the corresponding program, or may perform reserved viewing of the corresponding program.", "The receiver may provide the TV viewer with queries indicating whether to view the corresponding program when a current time reaches the start time of the reserved broadcast program, and then display the corresponding program.", "FIG.", "93 exemplarily illustrates screen images through which the role of a video component is displayed on ESG according to another embodiment of the present invention.", "Referring to FIG.", "93, the receiver may receive a request for the broadcast program schedule from the TV viewer, and may display the broadcast program schedule.", "Information regarding the broadcast program located after the current time may be displayed on the broadcast program schedule.", "Specific information indicating that the component corresponding to a specific role related to a specific program may be displayed on the ESG.", "For example, the broadcast program schedule may indicate the presence of the Alternative View element in the G program.", "If the user selects the G program, the receiver may provide the TV viewer with queries whether to view the corresponding program.", "If the receiver receives an indication command of the Alternative View element from the TV viewer, the receiver may replace the current image with those of the ‘Alternative View’ element, and then display the replaced result.", "Alternatively, the receiver transmits the ‘Alternative View’ related information to the companion device, and thus allows the companion device to display the Alternative View images.", "FIG.", "94 exemplarily illustrates screen images through which the role of a video component is displayed on ESG according to another embodiment of the present invention.", "Referring to FIG.", "94, the receiver may receive a request for the broadcast program schedule from the TV viewer, and may display the broadcast program schedule.", "Information regarding the broadcast program located after the current time may be displayed on the broadcast program schedule.", "Specific information indicating that the component corresponding to a specific role related to a specific program may be displayed on the ESG.", "For example, the broadcast program schedule may indicate the presence of the Follow Subject Video element in the program (I).", "If the user selects the I program, the receiver may provide the TV viewer with queries whether to confirm the Follow Subject Video element.", "If the receiver receives an indication command of the Follow Subject Video element from the TV viewer, the receiver may replace the current image with those of the Follow Subject Video element, and then display the replaced result.", "Alternatively, the receiver transmits the ‘Follow Subject Video’ related information to the companion device, and thus allows the companion device to display the Follow Subject Video images.", "FIG.", "95 exemplarily illustrates screen images through which the role of an audio component is displayed on ESG according to an embodiment of the present invention.", "Referring to FIG.", "95, the receiver may receive a request for the broadcast program schedule from the TV viewer, and may display the broadcast program schedule.", "Information regarding the broadcast program located after the current time may be displayed on the broadcast program schedule.", "Specific information indicating that the component corresponding to a specific role related to a specific program may be displayed on the ESG.", "For example, the broadcast program schedule may indicate the presence of the Music component element in the program (I).", "The Music component may correspond to a component configured to provide high-quality sound audio data for the corresponding program.", "As a result, the TV viewer who desires to receive high-quality sound audio data selects the I program, and can thus simultaneously consume the corresponding program and the Music component.", "FIG.", "96 exemplarily illustrates screen images through which the role of an audio component is displayed on ESG according to another embodiment of the present invention.", "Referring to FIG.", "96, the receiver may receive a request for the broadcast program schedule from the TV viewer, and may display the broadcast program schedule.", "Information regarding the broadcast program located after the current time may be displayed on the broadcast program schedule.", "Specific information indicating that the component corresponding to a specific role related to a specific program may be displayed on the ESG.", "For example, the broadcast program schedule may indicate the presence of the Dialogue component element in the G program.", "The Dialogue component may correspond to an additional component related to speech (or lines) of a specific actor or actress of the corresponding program.", "The TV viewer may select the G program providing the Dialogue component, may reproduce the dialogue of the actor or actress of the corresponding program through a separate speaker, and may consume the corresponding content.", "If the Dialogue component is separately provided, the receiver may also separately adjust the level of the Dialogue component.", "FIG.", "97 exemplarily illustrates screen images through which the role of an audio component is displayed on ESG according to another embodiment of the present invention.", "Referring to FIG.", "97, the receiver may receive a request for the broadcast program schedule from the TV viewer, and may display the broadcast program schedule.", "Information regarding the broadcast program located after the current time may be displayed on the broadcast program schedule.", "Specific information indicating that the component corresponding to a specific role related to a specific program may be displayed on the ESG.", "For example, the broadcast program schedule may indicate the presence of the Visually Impaired component element in the D program.", "The Visually Impaired component may correspond to the component configured to audibly provide visual content provided from the corresponding program.", "The Visually Impaired component may be used to provide the visually handicapped person (blind) with audible description related to the corresponding program.", "The TV viewer may select the program D configured to provide the Visually Impaired component, and thus consume the content corresponding to the Visually Impaired component.", "In this case, the receiver may reproduce the Visually Impaired component through the main device, may transmit the Visually Impaired component to the companion device, and may thus allow the companion device to reproduce the corresponding component.", "FIG.", "98 illustrates an exemplary case in which the role of a Closed Caption (CC) component is displayed on ESG according to an embodiment of the present invention.", "Referring to FIG.", "98, the receiver may receive a request for the broadcast program schedule from the TV viewer, and may display the broadcast program schedule.", "Information regarding the broadcast program located after the current time may be displayed on the broadcast program schedule.", "Specific information indicating that the component corresponding to a specific role related to a specific program may be displayed on the ESG.", "For example, the broadcast program schedule may indicate the presence of the Easy Reader component element in the D program.", "The Easy Reader component may correspond to the component configured to provide caption or subtitles of the content of the corresponding broadcast program.", "The caption or subtitles may be constructed in one or more languages.", "The TV viewer may select the D program configured to provide the Easy Reader component, and may consume the content corresponding to the Easy Reader component.", "In this case, the receiver may reproduce the Easy Reader component through the main device, and may transmit the Easy Reader component to the companion device, such that the companion device can reproduce the corresponding component.", "FIG.", "99 is a flowchart illustrating a method for receiving and processing broadcast signals according to an embodiment of the present invention.", "The broadcast signal transmission method according to an embodiment of the present invention may include generating service guide information including access information of a broadcast service and content data (SL99010), encoding the generated service guide information and content data (SL99020), and/or transmitting the encoded service guide information and content data (SL99030).", "The service guide information may include a service fragment indicating information about the broadcast service.", "In this case, the service guide information may indicate a service guide and the service fragment may indicate a Service fragment.", "According to another embodiment of the present invention, the service fragment may include service type information indicating the type of the broadcast service.", "In this case, the type of the broadcast service indicated by the service type information may include a linear service (Linear Service) that provides broadcast schedule information as well, an application based service (Appbased Service), and/or a companion screen service (CompanionScreen Service) using a companion device.", "In this case, the service type information may indicate information included in a ServiceType element.", "A detailed description thereof has been given with reference to FIGS.", "27, 28, 29, and 30.According to another embodiment of the present invention, the service guide information may include a component fragment indicating information about a component included in the broadcast service.", "The component fragment may include information that identifies the component fragment, component type information indicating the type of the component, and/or component role information indicating the role of the component.", "In this case, the component fragment may indicate a Component fragment.", "The information that identifies the component fragment may indicate information included in an id attribute.", "The component type information may indicate information included in a ComponentType element and the component role information may indicate information included in a ComponentRole element.", "A detailed description thereof has been given with reference to FIGS.", "31, 32, 60, 61, and 62.According to another embodiment of the present invention, the type of the component indicated by the component type information may include a continuous component (Continuous component) indicating a component represented in one continuous stream, an elementary component (Elementary component) indicating an independently encoded component, a composite component (Composite component) indicating a component that can be combined for one presentation, and/or a pick-one component (PickOne component) indicating a component selected for one presentation.", "A detailed description thereof has been given with reference to FIG.", "63.According to another embodiment of the present invention, the component role information may indicate that the component performs the role of a base layer for scalable video encoding, an enhancement layer for scalable video encoding, a left-eye image of 3D video, a right-eye image of 3D video, depth information of 3D video, music audio, dialog audio, and/or caption for children.", "In this case, the base layer for scalable video encoding may indicate a Base layer for scalable video encoding, the enhancement layer for scalable video encoding may indicate an Enhancement layer for scalable video encoding with level, the left-eye image of 3D video may indicate a 3D video left view, the right-eye image of 3D video may indicate a 3D video right view, the depth information of 3D video may indicate 3D video depth information, the music audio may indicate Music, the dialog audio may indicate Dialog, and the caption for children may indicate Easy reader.", "A detailed description thereof will be given with reference to FIG.", "64.FIG.", "100 is a diagram illustrating a broadcast signal reception apparatus according to an embodiment of the present invention.", "A broadcast signal reception apparatus L100030 according to an embodiment of the present invention may include a receiver L100010 and/or a decoder L100020.The receiver may receive service guide information including access information of a broadcast service and/or content data.", "The service guide information may include a service fragment indicating information about the broadcast service.", "The decoder may decode the received service guide information and/or content data.", "According to another embodiment of the present invention, the service fragment may include service type information indicating the type of the broadcast service.", "In this case, the type of the broadcast service indicated by the service type information may include a linear service (Linear Service) that provides broadcast schedule information, an application based service (Appbased Service), and/or a companion screen service (CompanionScreen Service) using a companion device.", "In this case, the service type information may indicate information included in a ServiceType element.", "A detailed description thereof has been given with reference to FIGS.", "27, 28, 29, and 30.According to another embodiment of the present invention, the service guide information may include a component fragment indicating information about a component included in the broadcast service.", "The component fragment may include information that identifies the component fragment, component type information indicating the type of the component, and/or component role information indicating the role of the component.", "In this case, the component fragment may indicate a Component fragment.", "The information that identifies the component fragment may indicate information included in an id attribute.", "The component type information may indicate information included in a ComponentType element and the component role information may indicate information included in a ComponentRole element.", "A detailed description thereof has been given with reference to FIGS.", "31, 32, 60, 61, and 62.According to another embodiment of the present invention, the type of the component indicated by the component type information may include a continuous component (Continuous component) indicating a component represented in one continuous stream, an elementary component (Elementary component) indicating an independently encoded component, a composite component (Composite component) indicating a component that can be combined for one presentation, and/or a pick-one component (PickOne component) indicating a component selected for one presentation.", "A detailed description thereof has been given with reference to FIG.", "63.According to another embodiment of the present invention, the component role information may indicate that the component performs the role of a base layer for scalable video encoding, an enhancement layer for scalable video encoding, a left-eye image of 3D video, a right-eye image of 3D video, depth information of 3D video, music audio, dialog audio, and/or caption for children.", "In this case, the base layer for scalable video encoding may indicate a Base layer for scalable video encoding, the enhancement layer for scalable video encoding may indicate an Enhancement layer for scalable video encoding with level, the left-eye image of 3D video may indicate a 3D video left view, the right-eye image of 3D video may indicate a 3D video right view, the depth information of 3D video may indicate 3D video depth information, the music audio may indicate Music, the dialog audio may indicate Dialog, and the caption for children may indicate Easy reader.", "A detailed description thereof will be given with reference to FIG.", "64.FIG.", "101 is a diagram illustrating a broadcast signal transmission apparatus according to an embodiment of the present invention.", "A broadcast signal transmission apparatus L101040 according to an embodiment of the present invention may include a generator L101010, an encoder L101020, and/or a transmitter L101030.The generator may generate service guide information including access information of a broadcast service and content data.", "The service guide information may include a service fragment indicating information about the broadcast service.", "The encoder may encode the generated service guide information and content data.", "The transmitter may transmit the encoded service guide information and content data.", "According to another embodiment of the present invention, the service fragment may include service type information indicating the type of the broadcast service.", "In this case, the type of the broadcast service indicated by the service type information may include a linear service (Linear Service) that provides broadcast schedule information, an application based service (Appbased Service), and/or a companion screen service (CompanionScreen Service) using a companion device.", "In this case, the service type information may indicate information included in a ServiceType element.", "A detailed description thereof has been given with reference to FIGS.", "27, 28, 29, and 30.FIG.", "102 is a diagram illustrating a broadcast signal reception method according to an embodiment of the present invention.", "The broadcast signal reception method according to an embodiment of the present invention may include receiving service guide information including access information of a broadcast service and content data (SL102010) and/or decoding the received service guide information and content data (SL102020).", "The service guide information may include a service fragment indicating information about the broadcast service.", "According to another embodiment of the present invention, the service fragment may include service type information indicating the type of the broadcast service.", "In this case, the type of the broadcast service indicated by the service type information may include a linear service (Linear Service) that provides broadcast schedule information, an application based service (Appbased Service), and/or a companion screen service (CompanionScreen Service) using a companion device.", "In this case, the service type information may indicate information included in a ServiceType element.", "A detailed description thereof has been given with reference to FIGS.", "27, 28, 29, and 30.According to another embodiment of the present invention, the service guide information may include a component fragment indicating information about a component included in the broadcast service.", "The component fragment may include information that identifies the component fragment, component type information indicating the type of the component, and/or component role information indicating the role of the component.", "In this case, the component fragment may indicate a Component fragment.", "The information that identifies the component fragment may indicate information included in an id attribute.", "The component type information may indicate information included in a ComponentType element and the component role information may indicate information included in a ComponentRole element.", "A detailed description thereof has been given with reference to FIGS.", "31, 32, 60, 61, and 62.The module or unit may be one or more processors designed to execute a series of execution steps stored in the memory (or the storage unit).", "Each step described in the above-mentioned embodiments may be implemented by hardware and/or processors.", "Each module, each block, and/or each unit described in the above-mentioned embodiments may be realized by hardware or processor.", "In addition, the above-mentioned methods of the present invention may be realized by codes written in recoding media configured to be read by a processor so that the codes can be read by the processor supplied from the apparatus.", "Although the description of the present invention is explained with reference to each of the accompanying drawings for clarity, it is possible to design new embodiment(s) by merging the embodiments shown in the accompanying drawings with each other.", "And, if a recording medium readable by a computer, in which programs for executing the embodiments mentioned in the foregoing description are recorded, is designed in necessity of those skilled in the art, it may belong to the scope of the appended claims and their equivalents.", "An apparatus and method according to the present invention may be non-limited by the configurations and methods of the embodiments mentioned in the foregoing description.", "And, the embodiments mentioned in the foregoing description can be configured in a manner of being selectively combined with one another entirely or in part to enable various modifications.", "In addition, a method according to the present invention can be implemented with processor-readable codes in a processor-readable recording medium provided to a network device.", "The processor-readable medium may include all kinds of recording devices capable of storing data readable by a processor.", "The processor-readable medium may include one of ROM, RAM, CD-ROM, magnetic tapes, floppy discs, optical data storage devices, and the like for example and also include such a carrier-wave type implementation as a transmission via Internet.", "Furthermore, as the processor-readable recording medium is distributed to a computer system connected via network, processor-readable codes can be saved and executed according to a distributive system.", "It will be appreciated by those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the inventions.", "Thus, it is intended that the present invention covers the modifications and variations of this invention provided they come within the scope of the appended claims and their equivalents.", "Both the product invention and the process invention are described in the specification and the description of both inventions may be supplementarily applied as needed.", "It will be appreciated by those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the inventions.", "Thus, it is intended that the present invention covers the modifications and variations of this invention provided they come within the scope of the appended claims and their equivalents.", "Both apparatus and method inventions are mentioned in this specification and descriptions of both of the apparatus and method inventions may be complementarily applicable to each other.", "Various embodiments have been described in the best mode for carrying out the invention.", "The embodiments of the present invention is available in a series of broadcast signal provision fields.", "It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the inventions.", "Thus, it is intended that the present invention covers the modifications and variations of this invention provided they come within the scope of the appended claims and their equivalents." ] ]
Patent_15872578
[ [ "METHOD AND DEVICE FOR COUPLING A MOTOR VEHICLE TO A TRAILER", "A method for coupling a motor vehicle having a trailer coupling to a coupling element of a trailer with at least partially automatic actuation of the motor vehicle based on data acquired by a surroundings sensor system, for example a surroundings sensor system of the motor vehicle is disclosed.", "A controlled change in level is carried out at an at least one axle by an air suspension system of the motor vehicle based on the acquired data.", "A control unit for carrying out the method is also disclosed." ], [ "1.A method for coupling a motor vehicle having a trailer coupling to a coupling element of a trailer with at least partially automatic actuation of the motor vehicle, the motor vehicle includes a surroundings sensor system, at least one axle, and an air suspension system, the method comprising: acquiring, from the surroundings sensor system, data; and controllably adjusting a level of the at least one axle of the motor vehicle by way of the air suspension system based on the acquired data.", "2.The method of claim 1, wherein the at least one axle includes a rear axle.", "3.The method of claim 2, wherein the at least one axle includes a front axle and adjusting a level of the at least one axle includes adjusting a level at the rear axle and adjusting a level at the front axle.", "4.The method of claim 1, further comprising: checking, using the data obtained by the surroundings sensor system, when the trailer coupling of the motor vehicle is at a level which is suitable for coupling, in comparison with the coupling element of the trailer.", "5.The method of claim 4, wherein when, in comparison with the coupling element of the trailer, the trailer coupling of the motor vehicle is not at a level which is suitable for coupling, controllably adjusting the level of the at least one axle.", "6.The method of claim 4, wherein when, in comparison with the coupling element of the trailer, the trailer coupling of the motor vehicle is at a level which is suitable for coupling, automated maneuvering takes place into a position in which the coupling element of the trailer is located above the trailer coupling of the motor vehicle.", "7.The method of claim 6, wherein after the position in which the coupling element of the trailer is located above the trailer coupling of the motor vehicle is reached, a controlled change in level takes place at the at least one axle in such a way that the trailer coupling of the motor vehicle engages into the coupling element of the trailer.", "8.The method of claim 4, further comprising: issuing a fault message to a driver of the vehicle if the check has revealed that, in comparison with the coupling element of the trailer, the trailer coupling of the motor vehicle is not located at a level which is suitable for coupling and a controlled change in level at the at least one axle such that the trailer coupling is moved to a suitable level cannot take place.", "9.The method of claim 1, further comprising: evaluating the data of the surroundings sensor system, and based on the evaluated data: automated maneuvering of the motor vehicle into an initial position in the vicinity of the trailer takes place; and checking the levels of the coupling element of the trailer and of the trailer coupling of the motor vehicle to determine if the motor vehicle is in the initial position.", "10.The method of claim 9, further comprising issuing a fault message to a driver of the vehicle if automated maneuvering into the initial position cannot take place.", "11.The method of claim 1, further comprising: inputting an input by a driver of the vehicle before acquiring data, wherein after inputting the input by the driver, the method is carried out independently of the driver or partially independently of the driver.", "12.A control unit for a motor vehicle designed to actuate at least one air suspension system of the motor vehicle, the control unit receives data of a surroundings sensor system, the control unit executes a method for coupling the motor vehicle having a trailer coupling to a coupling element of a trailer with at least partially automatic actuation of the motor vehicle, the method comprising: acquiring, from the surroundings sensor system, data; and controllably adjusting a level of at least one axle of the motor vehicle by way of the air suspension system based on the acquired data.", "13.The control unit of claim 12, wherein the at least one axle includes a rear axle.", "14.The control unit of claim 13, wherein the at least one axle includes a front axle and adjusting a level of the at least one axle includes adjusting a level at the rear axle and adjusting a level at the front axle.", "15.The control unit of claim 12, wherein the method further comprises: checking, using the data obtained by the surroundings sensor system, when the trailer coupling of the motor vehicle is at a level which is suitable for coupling, in comparison with the coupling element of the trailer.", "16.The control unit of claim 15, wherein the method further comprises when, in comparison with the coupling element of the trailer, the trailer coupling of the motor vehicle is not at a level which is suitable for coupling, controllably adjusting the level of the at least one axle.", "17.The control unit of claim 15, wherein the method further comprises when, in comparison with the coupling element of the trailer, the trailer coupling of the motor vehicle is at a level which is suitable for coupling, automated maneuvering takes place into a position in which the coupling element of the trailer is located above the trailer coupling of the motor vehicle.", "18.The control unit of claim 17, wherein after the position in which the coupling element of the trailer is located above the trailer coupling of the motor vehicle is reached, a controlled change in level takes place at the at least one axle in such a way that the trailer coupling of the motor vehicle engages into the coupling element of the trailer.", "19.The control unit of claim 15, the method further comprises issuing a fault message to a driver of the vehicle if the check has revealed that, in comparison with the coupling element of the trailer, the trailer coupling of the motor vehicle is not located at a level which is suitable for coupling and a controlled change in level at the at least one axle such that the trailer coupling is moved to a suitable level cannot take place.", "20.The control unit of claim 12, further comprising: evaluating the data of the surroundings sensor system, and based on the evaluated data: automated maneuvering of the motor vehicle into an initial position in the vicinity of the trailer takes place, and checking the levels of the coupling element of the trailer and of the trailer coupling of the motor vehicle to determine if the motor vehicle is in the initial position." ], [ "<SOH> BACKGROUND <EOH>Motor vehicles are currently increasingly equipped with a surroundings sensor system that is able to detect objects in the surroundings of the vehicle.", "The data of such surroundings sensors can be used to plan and carry out automatic maneuvers of the vehicle.", "Such methods are known, for example, from parking assistants.", "Similar to automatic parking systems, assistance systems for coupling a trailer to a vehicle are also known.", "In particular, in the dark or in bad weather, when the driver is alone, it may be difficult and uncomfortable for the driver to maneuver the vehicle properly for coupling the vehicle to the trailer hitch.", "It is often necessary to get in and out of the vehicle repeatedly, since a precisely targeted maneuver requires a certain amount of skill on the part of the driver.", "In addition, the trailer may be very difficult to handle, depending on the design and the load state.", "An assistance function which forms part of the maneuver or even the entire maneuver in a partially or fully automatic fashion reduces the probability of collisions and constitutes a large gain in comfort for the driver.", "A method for automatically coupling or docking by means of an image sensor system includes the coupling of a trailer which is detected by an object detection algorithm.", "Subsequently, an autonomous coupling maneuver can be carried out, where the necessary lock angle of the steering wheel and the speed for approaching the coupling of the trailer are calculated.", "A method is known in which a camera on-board the motor vehicle captures a towing head of a trailer as a maneuvering target and maneuvers the vehicle partially or fully automatically into a position that is suitable for coupling.", "The driver may be informed as to whether the towing head of the trailer drawbar is lower than the ball head of the trailer device, with the result that the driver can raise the trailer drawbar.", "A disadvantage is that vertical adjustments of the trailer drawbar have to be made by the driver.", "The driver must therefore, under certain circumstances, repeatedly get in and out of the vehicle, which is uncomfortable and possibly time-consuming.", "In addition, the vertical adjustment of the trailer drawbar can likewise be difficult, time-consuming or uncomfortable, depending on the design of the trailer and the load state." ], [ "<SOH> SUMMARY <EOH>The disclosure provides an improvement, or a more comfortable and/or more economical in terms of time method for partially or fully automatically coupling trailers.", "One aspect of the disclosure provides a partially or entirely automated coupling process in that level changes which are suitable for this purpose are carried out by means of an air suspension system contained in the vehicle.", "Data relating to the surroundings of the vehicle, which data is acquired by a surroundings sensor system, is evaluated in order to determine the suitable actuation.", "The evaluation of the surroundings sensor system data, combined with the actuation of the air suspension system, makes it possible to carry out the coupling process in a largely automated and as a result comfortable fashion.", "Implementations of the disclosure may include one or more of the following optional features.", "In some implementations, a change in level takes place at the rear axle.", "In some examples, a change in level additionally takes place at the front axle.", "In some implementations, a change in level of the entire vehicle and/or a pitching movement of the vehicle, takes place.", "A pitching movement is caused by the fact that a controlled change in level takes place at one axle in one direction, while the level at the other axle remains unchanged or else is changed in the opposite direction.", "Such a movement may be advantageous, since in this way the largest possible change in level of the trailer coupling of the motor vehicle is obtained with small changes to the levels of the axles, the trailer coupling usually located at the rear end of the vehicle.", "In some implementations, automated maneuvering of the motor vehicle into an initial position in the vicinity of the trailer occurs because of the evaluation of the data of the surroundings sensor system.", "The levels of the coupling element of the trailer and of the trailer coupling of the motor vehicle are checked when the motor vehicle is in this initial position.", "This has the advantage that the levels can be checked more accurately.", "The initial position may be determined in such way that the trailer coupling of the vehicle is in the direct vicinity of the coupling element of the trailer, with the result that the trailer coupling of the vehicle and the coupling element of the trailer are less far apart from one another than a predefined distance.", "In some examples, the levels of the trailer coupling of the vehicle and of the coupling element of the trailer are checked both directly after triggering the method and after the initial position is reached.", "The data obtained by the surroundings sensor system may be used to check whether, in comparison with the coupling element of the trailer, the trailer coupling of the motor vehicle is at a level that is suitable for coupling.", "A level of the trailer coupling of the motor vehicle which is suitable for coupling is understood here to be the level at which the trailer coupling fits under the coupling element of the trailer, with the result that the trailer coupling can be moved vertically under the coupling element of the trailer by maneuvering the vehicle and/or trailer.", "The level of the coupling element of the trailer may be acquired by the surroundings sensor system.", "In some implementations, the suitable level of the trailer coupling of the motor vehicle is determined in such a way that the highest point of the trailer coupling of the motor vehicle is lower, at least by a defined value, than the lowest point of the coupling element of the trailer.", "In some examples, a controlled change in level takes place at at least one axle if, in comparison with the coupling element of the trailer, the trailer coupling of the motor vehicle is not at a level which is suitable for coupling.", "Furthermore, automated maneuvering may take place into a position in which the coupling element of the trailer is located above (e.g., substantially vertically above) the trailer coupling of the motor vehicle if the check has revealed that, in comparison with the coupling element of the trailer, the trailer coupling of the motor vehicle is at a level which is suitable for coupling.", "Automated maneuvering has allows for the assistance system to position the motor vehicle very precisely based on the acquired surroundings data, with the result that the trailer coupling of the motor vehicle can come to be located very precisely under the coupling element of the trailer.", "In addition, when the maneuver is carried out manually by the driver as result of the often restricted view of the trailer coupling and coupling element and the necessary proximity of the motor vehicle to the trailer, there is an increased risk of a collision, which is reduced by carrying out the maneuver automatically.", "After the position in which the coupling element of the trailer is located above the trailer coupling of the motor vehicle is reached, a controlled change in level takes place at at least one axle in such way that the trailer coupling of the motor vehicle engages into the coupling element of the trailer.", "In some examples, the method is triggered by an input by the driver at an interface.", "The interface may be a pushbutton key.", "After the triggering by the driver, the method may be carried out independently of the driver.", "As an alternative to this, in some examples, the driver may trigger individual method steps by an input.", "In some implementations, a fault message is issued to the driver when the check as to whether the trailer coupling of the motor vehicle is located, in comparison with the coupling element of the trailer, at a level H which is suitable for coupling, has revealed that, in comparison with the coupling element of the trailer, the trailer coupling of the motor vehicle is not located at a level which is suitable for coupling and a controlled change in level at at least one axle such that the trailer coupling is moved to a suitable level H cannot take place.", "This may be the case, for example, if the technical configuration of the air suspension does not permit a suitable level to be set at the axle or axles or if the setting of the level would violate a predefined safety limiting value.", "In some implementations, safety limiting values are predefined for the vertical adjustment at the axles.", "This serves to prevent the vehicle from scraping along the ground, for example, along uneven parts of the ground, or serves to prevent a collision with uneven parts or low obstacles which can normally be traveled over (for example curb stone edges).", "Different safety limiting values are provided as a function of whether the vehicle is in a stationary state or is moving and/or what distance is to be travelled in the case of automatic maneuvering.", "Safety limiting values can additionally or alternatively be defined as a function of the information about the condition of the ground which is made available by means of the surroundings sensor system (for example divided into categories: even ground, uneven ground, obstacles present).", "Furthermore, a fault message may be issued to the driver if automated maneuvering into the next position provided by the method cannot take place.", "This may be the case, for example, if no suitable trajectory can be calculated for the automatic maneuvering, because e.g., there is not sufficient space available or obstacles have been detected between the motor vehicle and the trailer by the surroundings sensor system.", "The method may be carried out by a controller which is specially provided for this purpose or by a controller which is already present, depending on the design.", "In this context, controllers which are additionally present in the vehicle can also be actuated for individual method steps.", "In vehicles that contain a parking assistant, a position pre-definition may be transferred to the parking assistant, which maneuvers the vehicle into the predefined position.", "The disclosure also relates to a control unit in which a method according to the disclosure is carried out.", "The details of one or more implementations of the disclosure are set forth in the accompanying drawings and the description below.", "Other aspects, features, and advantages will be apparent from the description and drawings, and from the claims." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application claims the benefit of PCT Application PCT/EP2016/066523, filed Jul.", "12, 2016, which claims priority to German Application DE 10 2015 213 404.0, filed Jul.", "16, 2015.The disclosures of the above applications are incorporated herein by reference.", "TECHNICAL FIELD The disclosure relates to a method and a device for coupling a trailer to a motor vehicle.", "BACKGROUND Motor vehicles are currently increasingly equipped with a surroundings sensor system that is able to detect objects in the surroundings of the vehicle.", "The data of such surroundings sensors can be used to plan and carry out automatic maneuvers of the vehicle.", "Such methods are known, for example, from parking assistants.", "Similar to automatic parking systems, assistance systems for coupling a trailer to a vehicle are also known.", "In particular, in the dark or in bad weather, when the driver is alone, it may be difficult and uncomfortable for the driver to maneuver the vehicle properly for coupling the vehicle to the trailer hitch.", "It is often necessary to get in and out of the vehicle repeatedly, since a precisely targeted maneuver requires a certain amount of skill on the part of the driver.", "In addition, the trailer may be very difficult to handle, depending on the design and the load state.", "An assistance function which forms part of the maneuver or even the entire maneuver in a partially or fully automatic fashion reduces the probability of collisions and constitutes a large gain in comfort for the driver.", "A method for automatically coupling or docking by means of an image sensor system includes the coupling of a trailer which is detected by an object detection algorithm.", "Subsequently, an autonomous coupling maneuver can be carried out, where the necessary lock angle of the steering wheel and the speed for approaching the coupling of the trailer are calculated.", "A method is known in which a camera on-board the motor vehicle captures a towing head of a trailer as a maneuvering target and maneuvers the vehicle partially or fully automatically into a position that is suitable for coupling.", "The driver may be informed as to whether the towing head of the trailer drawbar is lower than the ball head of the trailer device, with the result that the driver can raise the trailer drawbar.", "A disadvantage is that vertical adjustments of the trailer drawbar have to be made by the driver.", "The driver must therefore, under certain circumstances, repeatedly get in and out of the vehicle, which is uncomfortable and possibly time-consuming.", "In addition, the vertical adjustment of the trailer drawbar can likewise be difficult, time-consuming or uncomfortable, depending on the design of the trailer and the load state.", "SUMMARY The disclosure provides an improvement, or a more comfortable and/or more economical in terms of time method for partially or fully automatically coupling trailers.", "One aspect of the disclosure provides a partially or entirely automated coupling process in that level changes which are suitable for this purpose are carried out by means of an air suspension system contained in the vehicle.", "Data relating to the surroundings of the vehicle, which data is acquired by a surroundings sensor system, is evaluated in order to determine the suitable actuation.", "The evaluation of the surroundings sensor system data, combined with the actuation of the air suspension system, makes it possible to carry out the coupling process in a largely automated and as a result comfortable fashion.", "Implementations of the disclosure may include one or more of the following optional features.", "In some implementations, a change in level takes place at the rear axle.", "In some examples, a change in level additionally takes place at the front axle.", "In some implementations, a change in level of the entire vehicle and/or a pitching movement of the vehicle, takes place.", "A pitching movement is caused by the fact that a controlled change in level takes place at one axle in one direction, while the level at the other axle remains unchanged or else is changed in the opposite direction.", "Such a movement may be advantageous, since in this way the largest possible change in level of the trailer coupling of the motor vehicle is obtained with small changes to the levels of the axles, the trailer coupling usually located at the rear end of the vehicle.", "In some implementations, automated maneuvering of the motor vehicle into an initial position in the vicinity of the trailer occurs because of the evaluation of the data of the surroundings sensor system.", "The levels of the coupling element of the trailer and of the trailer coupling of the motor vehicle are checked when the motor vehicle is in this initial position.", "This has the advantage that the levels can be checked more accurately.", "The initial position may be determined in such way that the trailer coupling of the vehicle is in the direct vicinity of the coupling element of the trailer, with the result that the trailer coupling of the vehicle and the coupling element of the trailer are less far apart from one another than a predefined distance.", "In some examples, the levels of the trailer coupling of the vehicle and of the coupling element of the trailer are checked both directly after triggering the method and after the initial position is reached.", "The data obtained by the surroundings sensor system may be used to check whether, in comparison with the coupling element of the trailer, the trailer coupling of the motor vehicle is at a level that is suitable for coupling.", "A level of the trailer coupling of the motor vehicle which is suitable for coupling is understood here to be the level at which the trailer coupling fits under the coupling element of the trailer, with the result that the trailer coupling can be moved vertically under the coupling element of the trailer by maneuvering the vehicle and/or trailer.", "The level of the coupling element of the trailer may be acquired by the surroundings sensor system.", "In some implementations, the suitable level of the trailer coupling of the motor vehicle is determined in such a way that the highest point of the trailer coupling of the motor vehicle is lower, at least by a defined value, than the lowest point of the coupling element of the trailer.", "In some examples, a controlled change in level takes place at at least one axle if, in comparison with the coupling element of the trailer, the trailer coupling of the motor vehicle is not at a level which is suitable for coupling.", "Furthermore, automated maneuvering may take place into a position in which the coupling element of the trailer is located above (e.g., substantially vertically above) the trailer coupling of the motor vehicle if the check has revealed that, in comparison with the coupling element of the trailer, the trailer coupling of the motor vehicle is at a level which is suitable for coupling.", "Automated maneuvering has allows for the assistance system to position the motor vehicle very precisely based on the acquired surroundings data, with the result that the trailer coupling of the motor vehicle can come to be located very precisely under the coupling element of the trailer.", "In addition, when the maneuver is carried out manually by the driver as result of the often restricted view of the trailer coupling and coupling element and the necessary proximity of the motor vehicle to the trailer, there is an increased risk of a collision, which is reduced by carrying out the maneuver automatically.", "After the position in which the coupling element of the trailer is located above the trailer coupling of the motor vehicle is reached, a controlled change in level takes place at at least one axle in such way that the trailer coupling of the motor vehicle engages into the coupling element of the trailer.", "In some examples, the method is triggered by an input by the driver at an interface.", "The interface may be a pushbutton key.", "After the triggering by the driver, the method may be carried out independently of the driver.", "As an alternative to this, in some examples, the driver may trigger individual method steps by an input.", "In some implementations, a fault message is issued to the driver when the check as to whether the trailer coupling of the motor vehicle is located, in comparison with the coupling element of the trailer, at a level H which is suitable for coupling, has revealed that, in comparison with the coupling element of the trailer, the trailer coupling of the motor vehicle is not located at a level which is suitable for coupling and a controlled change in level at at least one axle such that the trailer coupling is moved to a suitable level H cannot take place.", "This may be the case, for example, if the technical configuration of the air suspension does not permit a suitable level to be set at the axle or axles or if the setting of the level would violate a predefined safety limiting value.", "In some implementations, safety limiting values are predefined for the vertical adjustment at the axles.", "This serves to prevent the vehicle from scraping along the ground, for example, along uneven parts of the ground, or serves to prevent a collision with uneven parts or low obstacles which can normally be traveled over (for example curb stone edges).", "Different safety limiting values are provided as a function of whether the vehicle is in a stationary state or is moving and/or what distance is to be travelled in the case of automatic maneuvering.", "Safety limiting values can additionally or alternatively be defined as a function of the information about the condition of the ground which is made available by means of the surroundings sensor system (for example divided into categories: even ground, uneven ground, obstacles present).", "Furthermore, a fault message may be issued to the driver if automated maneuvering into the next position provided by the method cannot take place.", "This may be the case, for example, if no suitable trajectory can be calculated for the automatic maneuvering, because e.g., there is not sufficient space available or obstacles have been detected between the motor vehicle and the trailer by the surroundings sensor system.", "The method may be carried out by a controller which is specially provided for this purpose or by a controller which is already present, depending on the design.", "In this context, controllers which are additionally present in the vehicle can also be actuated for individual method steps.", "In vehicles that contain a parking assistant, a position pre-definition may be transferred to the parking assistant, which maneuvers the vehicle into the predefined position.", "The disclosure also relates to a control unit in which a method according to the disclosure is carried out.", "The details of one or more implementations of the disclosure are set forth in the accompanying drawings and the description below.", "Other aspects, features, and advantages will be apparent from the description and drawings, and from the claims.", "DESCRIPTION OF DRAWINGS FIG.", "1 shows a schematic illustration of individual exemplary method steps.", "FIG.", "2 shows a schematic flow chart of an exemplary method.", "Like reference symbols in the various drawings indicate like elements.", "DETAILED DESCRIPTION FIG.", "1 illustrates individual sections of an exemplary method with reference to schematic drawings of a vehicle and of a trailer.", "A motor vehicle 120 is shown together with a trailer coupling 122 and a trailer 121 with a coupling element 123.Arrows indicate movements of the motor vehicle.", "In method step 106, the motor vehicle 120 is maneuvered in an automated fashion into an initial position AP in the vicinity of the trailer 121.In method step 108, the vehicle 120 is in the initial position AP.", "The rear axle is lowered by the air suspension system (indicated by the arrow 130), with the result that the trailer coupling 122 is located at a level H above the ground.", "In this context, the level H is determined such that the highest point of the trailer coupling 122 is below the lowest point of the coupling element 123.In method step 112, the vehicle 120 is automatically maneuvered into a coupling position P, with the result that the trailer coupling 122 is located essentially vertically under the coupling element 123.In method step 113, the rear axle is raised again by the air suspension system (indicated by the arrow 140), with the result that the trailer coupling 122 engages in the coupling element 123.A method sequence of the disclosure is shown in FIG.", "2.The method for coupling a motor vehicle to a trailer starts, for example, in block 1 by an input from the driver at an interface, e.g.", "by activating a pushbutton key.", "Subsequently, a control unit automatically carries out the method.", "In this case, various control systems and actuators of the vehicle can be actuated.", "In this context, for example driver-independent interventions can be made into at least one of the following systems: Steering system, braking (individually or as the entire braking system), drive, air suspension system.", "In block 2, the surroundings are monitored by a surroundings sensor system arranged in the vehicle.", "Based on the data it is detected whether a trailer is located in the vicinity and where the trailer and the associated coupling element are located.", "In order to avoid incorrect actuations, the detected position of the coupling element of the trailer is confirmed by the driver.", "For example, this can be done by the detected trailer and the detected coupling element being displayed and marked visually.", "The driver then confirms by inputting an input that the desired target for the coupling process has been correctly detected.", "In motor vehicles with a folding-out trailer coupling, in the optional Block 3 automatic folding out of the trailer coupling of the motor vehicle may be carried out.", "In block 4, a suitable trajectory for the motor vehicle is subsequently calculated, in order to maneuver the motor vehicle in an automated fashion into an initial position AP in the vicinity of the trailer.", "In block 4 it is also checked whether there is sufficient space available for the maneuvering operation.", "If this is not the case (no in block 4), a fault message is issued to the driver in block 5.If the result of the check in block 4 is positive (yes), the vehicle maneuvers automatically into the initial position (AP) in block 6.Subsequently, in block 7, data of the surroundings sensor system are evaluated in order to determine whether the trailer coupling of the motor vehicle is located, in comparison with the coupling element of the trailer, at a level H that is suitable for coupling.", "If the result is positive (yes in block 7), the vehicle is maneuvered directly into a coupling position P (block 12).", "This is the position in which the trailer coupling of the motor vehicle is located essentially vertically under the coupling element of the trailer.", "If the check in block 7 reveals that the trailer coupling of the motor vehicle is not located, in comparison with the coupling element of the trailer, at a level H which is suitable for coupling (no in block 7), the rear axle of the motor vehicle is lowered in block 8 by the air suspension system.", "Optionally, in block 9, the front axle of the motor vehicle is additionally raised by the air suspension system, in order to lower the trailer coupling of the motor vehicle further.", "Subsequently, in block 10, it is checked again whether the trailer coupling of the motor vehicle is located, in comparison with the coupling element of the trailer, at a level H which is suitable for coupling.", "If this is still not the case (no in block 10), a fault message (block 11) is issued to the driver and the method is ended (block 16).", "The driver then has, for example, the possibility of manually changing the level of the coupling element of the trailer coupling and of re-starting or continuing the method by inputting (e.g., an input).", "If the checking of the levels of the trailer coupling of the motor vehicle and of the coupling element of the trailer in block 10 reveals that they are located at levels which are suitable for coupling (yes in block 10), the vehicle is maneuvered into the coupling position P in block 12.After the coupling position P, at which the trailer coupling of the motor vehicle is located under the coupling element of the trailer, is reached, in block 13 the rear axle is raised again by the air suspension system.", "Optionally, the front axle is lowered again in block 14.By raising the rear axle and, if appropriate, lowering the front axle, the trailer coupling of the motor vehicle engages into the coupling element of the trailer, and the trailer is coupled.", "In block 15, it is signaled to the driver that the coupling process has been successfully carried out.", "The method is ended in block 16.The driver may subsequently perform the further customary steps for concluding the coupling process, such as for example forming the electrical connection and releasing the handbrake of the trailer.", "In one preferred embodiment of the invention, these steps are also carried out partially or entirely automatically, depending on the equipment of the trailer.", "A number of implementations have been described.", "Nevertheless, it will be understood that various modifications may be made without departing from the spirit and scope of the disclosure.", "Accordingly, other implementations are within the scope of the following claims." ] ]
Patent_15872583
[ [ "SYSTEMS AND METHODS FOR COMPRESSING PLASMA", "Embodiments of systems and methods for compressing plasma are described in which plasma pressures above the breaking point of solid material can be achieved by injecting a plasma into a funnel of liquid metal in which the plasma is compressed and/or heated." ], [ "1.A liquid metal funnel system configured for compressing plasma, the liquid metal funnel system comprising: a liquid metal funnel having a passage having a first inner diameter at a first end of the passage and a second inner diameter at a second end of the passage, the second inner diameter less than the first inner diameter, the liquid metal funnel oriented such that the first end of the passage is higher than the second end of the passage; and a liquid guide extending along a longitudinal axis of the passage, the liquid guide spaced apart from an inner surface of the liquid metal funnel thereby providing an annular space between the inner surface of the liquid metal funnel and an outer surface of the liquid guide, wherein the liquid metal funnel is configured to receive a plasma from a plasma injector and to compress the plasma as the plasma moves along the annular space from the first end of the passage toward the second end of the passage.", "2.The liquid metal funnel system of claim 1, wherein a pressure of the plasma received from the plasma injector is less than a pressure of the plasma when the plasma is below the first end of the passage.", "3.The liquid metal funnel system of claim 1, wherein the plasma comprises a compact toroid.", "4.The liquid metal funnel system of claim 1, wherein the system is configured such that the liquid metal funnel comprises liquid metal that flows at least partially under gravity from the first end toward the second end.", "5.The liquid metal funnel system of claim 1, further comprising a liquid metal circulation system configured to circulate the liquid metal such that the liquid metal is capable of flowing from the first end to the second end.", "6.The liquid metal funnel system of claim 5, wherein the liquid metal circulation system comprises a confinement system and a pump system, the liquid metal funnel disposed in the confinement system, the pump system configured to pump the liquid metal from a lower end of the confinement system to an upper end of the confinement system.", "7.The liquid metal funnel system of claim 1, further comprising a liquid guide injection system configured to inject the liquid guide substantially along the axis of the passage of the liquid metal funnel.", "8.The liquid metal funnel system of claim 1, wherein the liquid guide is configured to be electrically isolated from the liquid metal funnel.", "9.The liquid metal funnel system of claim 1, wherein the passage has an inner surface, and a portion of the inner surface has a cross-section that is substantially circular, substantially oval, or substantially polygonal.", "10.The liquid metal funnel system of claim 1, wherein the passage has a portion that is substantially cylindrical." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>Embodiments of systems and methods for compressing plasma are disclosed.", "Some embodiments comprise electrically accelerating a plasma, for example, by using a plasma accelerator such as, e.g., a rail gun.", "The plasma can be accelerated into a funnel of liquid metal where the plasma is further compressed.", "The use of the liquid metal allows high plasma densities to be achieved, because, in some embodiments, the pressure attained can be higher than the breakpoint or yield strength of solid materials typically used in the apparatus itself.", "In certain embodiments, a low density and temperature spheromak or toroidal plasma is formed using a plasma gun, for example, a magnetized coaxial gun.", "The toroidal plasma is electrically accelerated, compressed and heated to a high density and temperature using a plasma accelerator (e.g., a tapered rail gun) that extends towards a liquid metal funnel.", "The liquid metal funnel in some implementations can be formed of molten metal such as, for example, molten lead-lithium (PbLi).", "In various embodiments, the toroidal plasma can be formed as a field-reversed configuration (FRC) or other compact toroid.", "In some implementations, the plasma can include a fusionable material such as, for example, isotopes of light elements (e.g., deuterium, tritium, helium-3, lithium-6, and/or lithium-7).", "The higher plasma densities and/or temperatures that are achievable in some such implementations can be sufficient for the initiation of fusion reactions.", "Some fusion reactions produce neutrons.", "Therefore, some embodiments of the system can be configured as neutron sources.", "Some embodiments of the systems and methods may provide sufficient fusion reactions for net energy production to occur (e.g., above breakeven).", "An embodiment of an apparatus for compressing plasma is disclosed.", "The apparatus comprises a plasma gun configured to generate a compact toroid of plasma, a plasma accelerator, and a liquid funnel system.", "The plasma accelerator has a first end, a second end, and a longitudinal axis between the first end and the second end.", "The plasma accelerator is configured to receive the compact toroid at the first end and to accelerate the compact toroid along the longitudinal axis toward the second end.", "The liquid funnel system comprises a liquid funnel having a substantially cylindrical passage substantially aligned with the longitudinal axis of the plasma accelerator.", "The passage has a first inner diameter at a top end of the passage and a second inner diameter at a bottom end of the passage.", "The second inner diameter can be less than the first inner diameter in some embodiments.", "The liquid funnel system is configured to receive the compact toroid from the second end of the plasma accelerator and to compress the compact toroid as the compact toroid moves along the passage from the top end toward the bottom end.", "The system can be configured such that a pressure of the compact toroid when below the top end is greater than a pressure of the compact toroid when above the top end.", "An embodiment of a liquid metal funnel system configured for compressing plasma is disclosed.", "The liquid metal funnel system comprises a liquid metal funnel having a substantially cylindrical passage having a first inner diameter at a first end of the passage and a second inner diameter at a second end of the passage.", "The second inner diameter can be less than the first inner diameter.", "The liquid metal funnel can be oriented such that the first end of the passage is higher than the second end of the passage.", "The liquid metal funnel can be configured to receive a plasma from a plasma injector and to compress the plasma as the plasma moves along the passage from the first end toward the second end.", "An embodiment of a method of compressing a plasma is disclosed.", "The method comprises generating a toroidal plasma, accelerating the toroidal plasma along a longitudinal direction, and introducing the accelerated toroidal plasma into a passage in a liquid funnel.", "The passage can have a first size at a first end of the passage and a second size at a second end of the passage.", "The second size can be smaller than the first size.", "The method can also include compressing the toroidal plasma as the toroidal plasma moves from the first end of the passage toward the second end of the passage." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a division of U.S. patent application Ser.", "No.", "15/200,919, filed Jul.", "1, 2016, entitled “SYSTEMS AND METHODS FOR COMPRESSING PLASMA,” which is a division of U.S. patent application Ser.", "No.", "13/935,281, filed Jul.", "3, 2013, entitled “SYSTEMS AND METHODS FOR COMPRESSING PLASMA,” now U.S. Pat.", "No.", "9,424,955, which is a continuation of U.S. patent application Ser.", "No.", "12/699,725, filed Feb. 3, 2010, entitled “SYSTEMS AND METHODS FOR COMPRESSING PLASMA,” now U.S. Pat.", "No.", "8,537,958, which claims the benefit under 35 U.S.C.", "§ 119(e) of U.S.", "Provisional Patent Application No.", "61/149,886, filed Feb. 4, 2009, entitled “SYSTEMS AND METHODS FOR ACCELERATING AND COMPRESSING A PLASMA;” each of the foregoing is hereby incorporated by reference herein in its entirety.", "BACKGROUND Field The present disclosure relates to embodiments of systems and methods for compressing plasma.", "In certain such embodiments, a plasma toroid is compressed using a liquid metal funnel.", "Description of the Related Art Various systems for heating and compressing plasmas to high temperatures and densities have been described.", "One approach for accomplishing plasma heating and compression by spherical focusing of a large amplitude acoustic pressure wave in a liquid medium is described in U.S. Patent Publication No.", "2006/0198486, published Sep. 7, 2006, entitled “Pressure Wave Generator and Controller for Generating a Pressure Wave in a Fusion Reactor”, which is hereby incorporated by reference herein in its entirety.", "In certain embodiments of this approach, a plurality of pistons is arranged around a substantially spherical vessel containing a liquid medium.", "A vortex or cavity is created in the liquid medium.", "The pistons are accelerated and strike the outer wall of the vessel generating an acoustic wave.", "The acoustic wave generated in the liquid medium converges and envelopes a plasma that is introduced into the vortex, thereby heating and compressing the plasma.", "A pressure wave generator of the type described in U.S. Patent Publication No.", "2006/0198486 can be employed in a Magnetized Target Fusion (MTF) reactor as described, for example, in U.S. Patent Publication No.", "2006/0198483, published Sep. 7, 2006, entitled “Magnetized Plasma Fusion Reactor,” which is hereby incorporated by reference herein in its entirety.", "In certain such implementations, a magnetized plasma is introduced into a vortex that is created in the liquid medium, such as molten lead-lithium (PbLi).", "The acoustic wave produced by the impact of pistons surrounding the spherical reactor vessel can compress the magnetized plasma to high density and temperature.", "In some embodiments of the above-described devices, compressed gas such as steam or air can be used to accelerate the pistons.", "Typically the desired piston impact velocity for plasma compression is of the order of 100 m/s, and so generally a compressed gas pressure of about 1,300 psi is used to accelerate the pistons.", "To achieve the symmetry of implosion that may be useful or desirable in some implementations, the timing of the piston firing, trajectory, and impact is precisely controlled for each piston.", "For example, for some plasma compression implementations, all the pistons preferably strike the vessel wall within about 1 μs of each other.", "In some such implementations, a servo control system can be used to measure precisely the position of each piston and control its trajectory to attain the requisite impact time.", "Whilst certain embodiments of such mechanical compression systems are attractive from, for example, a cost perspective, certain such implementations may need frequent maintenance, especially in applications where the repetition frequency of piston firing is high.", "SUMMARY Embodiments of systems and methods for compressing plasma are disclosed.", "Some embodiments comprise electrically accelerating a plasma, for example, by using a plasma accelerator such as, e.g., a rail gun.", "The plasma can be accelerated into a funnel of liquid metal where the plasma is further compressed.", "The use of the liquid metal allows high plasma densities to be achieved, because, in some embodiments, the pressure attained can be higher than the breakpoint or yield strength of solid materials typically used in the apparatus itself.", "In certain embodiments, a low density and temperature spheromak or toroidal plasma is formed using a plasma gun, for example, a magnetized coaxial gun.", "The toroidal plasma is electrically accelerated, compressed and heated to a high density and temperature using a plasma accelerator (e.g., a tapered rail gun) that extends towards a liquid metal funnel.", "The liquid metal funnel in some implementations can be formed of molten metal such as, for example, molten lead-lithium (PbLi).", "In various embodiments, the toroidal plasma can be formed as a field-reversed configuration (FRC) or other compact toroid.", "In some implementations, the plasma can include a fusionable material such as, for example, isotopes of light elements (e.g., deuterium, tritium, helium-3, lithium-6, and/or lithium-7).", "The higher plasma densities and/or temperatures that are achievable in some such implementations can be sufficient for the initiation of fusion reactions.", "Some fusion reactions produce neutrons.", "Therefore, some embodiments of the system can be configured as neutron sources.", "Some embodiments of the systems and methods may provide sufficient fusion reactions for net energy production to occur (e.g., above breakeven).", "An embodiment of an apparatus for compressing plasma is disclosed.", "The apparatus comprises a plasma gun configured to generate a compact toroid of plasma, a plasma accelerator, and a liquid funnel system.", "The plasma accelerator has a first end, a second end, and a longitudinal axis between the first end and the second end.", "The plasma accelerator is configured to receive the compact toroid at the first end and to accelerate the compact toroid along the longitudinal axis toward the second end.", "The liquid funnel system comprises a liquid funnel having a substantially cylindrical passage substantially aligned with the longitudinal axis of the plasma accelerator.", "The passage has a first inner diameter at a top end of the passage and a second inner diameter at a bottom end of the passage.", "The second inner diameter can be less than the first inner diameter in some embodiments.", "The liquid funnel system is configured to receive the compact toroid from the second end of the plasma accelerator and to compress the compact toroid as the compact toroid moves along the passage from the top end toward the bottom end.", "The system can be configured such that a pressure of the compact toroid when below the top end is greater than a pressure of the compact toroid when above the top end.", "An embodiment of a liquid metal funnel system configured for compressing plasma is disclosed.", "The liquid metal funnel system comprises a liquid metal funnel having a substantially cylindrical passage having a first inner diameter at a first end of the passage and a second inner diameter at a second end of the passage.", "The second inner diameter can be less than the first inner diameter.", "The liquid metal funnel can be oriented such that the first end of the passage is higher than the second end of the passage.", "The liquid metal funnel can be configured to receive a plasma from a plasma injector and to compress the plasma as the plasma moves along the passage from the first end toward the second end.", "An embodiment of a method of compressing a plasma is disclosed.", "The method comprises generating a toroidal plasma, accelerating the toroidal plasma along a longitudinal direction, and introducing the accelerated toroidal plasma into a passage in a liquid funnel.", "The passage can have a first size at a first end of the passage and a second size at a second end of the passage.", "The second size can be smaller than the first size.", "The method can also include compressing the toroidal plasma as the toroidal plasma moves from the first end of the passage toward the second end of the passage.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1A is a schematic cross-sectional diagram showing an embodiment of a system compressing a plasma in a tapered liquid metal funnel.", "In this embodiment, a plasma gun forms a compact toroid that is accelerated by a plasma accelerator toward the liquid metal funnel.", "FIG.", "1B is a schematic cross-sectional diagram showing another embodiment of a system for compressing a plasma in a liquid metal funnel system.", "In this embodiment, the funnel system comprises a liquid metal funnel and an axial liquid metal guide disposed substantially along a central axis of the funnel.", "In this embodiment, the plasma accelerator comprises a plasma restrictor that comprises a constriction in a propagation channel of the accelerator.", "FIG.", "1C is a schematic cross-sectional diagram showing another embodiment of a system for compressing a plasma in a liquid metal funnel system.", "In this embodiment, the plasma accelerator comprises a plasma restrictor that comprises one or more magnetic coils.", "FIG.", "1D is a perspective cutaway view of an embodiment of a system for compressing a plasma.", "The embodiment shown in FIG.", "1C is generally similar to the embodiment schematically shown in FIG.", "1B.", "FIG.", "2 is a graph indicating an example calculation of the energy of the plasma to achieve the Lawson criteria for various plasma densities and an example calculation of the magnetic pressure of a plasma at various plasma densities.", "These example calculations are based on Bohm diffusion and certain other assumptions described below.", "Note that a pressure of 1 atmosphere (atm) is about 105 Pa.", "FIG.", "3 is a schematic cross-sectional diagram showing an example of a toroidal plasma within a tapered liquid metal funnel.", "FIG.", "4 is a graph showing an example calculation of the plasma energy to achieve the Lawson criteria for various plasma densities, taking into account various power losses that can occur in an example embodiment of a plasma compression system.", "DETAILED DESCRIPTION OF EMBODIMENTS Tapered coaxial plasma spheromak accelerators have been built and studied in the past for, e.g., x-ray production, tokomak fuelling, and plasma physics research.", "However, the maximum achievable magnetic pressure has been limited by the strength of the solid materials used in the apparatus (e.g., a fracture limit, yield strength, or breakpoint of the solid materials).", "In certain embodiments of the present approach, the magnetic pressure that can be achieved has been increased significantly beyond this limit by using a tapered or funnel-shaped liquid metal tube as described in more detail below.", "With reference to the drawings, FIGS.", "1A-1D schematically illustrate several embodiments of a system 1000 that can be used to accelerate and compress a plasma.", "The embodiments shown in FIGS.", "1A-1D comprise a plasma gun 100 configured to generate a toroidal plasma (for example, a compact toroid such as, e.g., a spheromak), a plasma accelerator 110 configured to accelerate the plasma along a longitudinal axis 115 of the accelerator 110, and a liquid metal funnel system 120 into which the plasma accelerated by the accelerator 110 is introduced for further compression.", "In various embodiments, the plasma gun 100 may comprise a magnetized plasma gun that has a gun axis that is substantially aligned or coaxial with the longitudinal axis 115 of the accelerator 110.In some embodiments, the plasma gun 100 comprises a Marshall-type plasma gun.", "In various embodiments, the plasma accelerator 110 may comprise a rail gun configured to accelerate the plasma using magnetic and/or electromagnetic forces.", "In some embodiments, the plasma accelerator 110 can provide some degree of plasma compression as the plasma is accelerated along the longitudinal axis 115.For example, the rail gun can comprise one or more tapered electrodes to compress the plasma during acceleration along the longitudinal axis 115.The liquid metal funnel system 120 may comprise a liquid metal funnel, cylinder, or tube 8 having a passage substantially aligned with the longitudinal axis 115 of the accelerator 110.In some embodiments, a cross-section and/or inner diameter of the passage can change from an upper end of the funnel to a lower end of the funnel, e.g., the cross-section (and/or inner diameter) can decrease to allow the plasma to be compressed as the plasma moves below the upper end and toward the lower end.", "In certain embodiments, the plasma gun 100 and/or the plasma accelerator 110 are positioned substantially above the liquid funnel system 120.In certain embodiments, the upper end of the funnel 8 is substantially above the lower end of the funnel 8.The toroidal plasma generated by the plasma gun 100 can be a compact toroid such as, e.g., a spheromak, which is a toroidal plasma confined by its own magnetic field produced by current flowing in the conductive plasma.", "In other embodiments, the compact toroid can be a field-reversed configuration (FRC) of plasma, which may have substantially closed magnetic field lines with little or no central penetration of the field lines.", "As schematically illustrated in the embodiments shown in FIGS.", "1A-1D, gas from one or more tanks 4 is introduced into the gun by fast puff valves 3.In some implementations, the initial gas pressure is about 15 pounds per square inch (psi) (e.g., about 1.03×105 Pa).", "The gas may comprise a fusionable material.", "For example, the fusionable material may comprise one or more isotopes of light elements such as, e.g., isotopes of hydrogen (e.g., deuterium and/or tritium), isotopes of helium (e.g., helium-3), and/or isotopes of lithium (e.g., lithium-6 and/or lithium-7).", "Other fusionable materials can be used.", "Combinations of elements and isotopes can be used.", "For example, in some implementations, a 50% deuterium-50% tritium gas mixture is introduced from the tank 4 using about 100 puff valves 3.Each pulse from the valves introduces about 2 mg of gas, in one implementation.", "In other embodiments, a different number of valves can be used and/or a different mass of gas can be introduced.", "In other implementations, the percentages of deuterium and tritium, respectively, can be different from 50%-50%.", "Coils 5 induce a magnetic field in the space between an outer electrode 7 and a formation electrode 14.The coils 5 can be configured to provide a mostly radial stuffing magnetic field of about 0.8 Tesla in some implementations.", "In the embodiment schematically illustrated in FIGS.", "1A-1C, the formation electrode 14 is substantially cylindrical, and the outer electrode 7 is tapered inward toward the liquid metal funnel system 120.In the embodiments schematically illustrated in FIGS.", "1B-1D, the magnetic field is produced by 3 magnetic coils 5a, 5b, and 5c, although fewer or greater numbers of coils may be used in other embodiments.", "In some embodiments, the coil 5a comprises about 140 turns of hollow square 6 mm×6 mm copper wire.", "During operation of the system, the wire can carry a current of about 1000 Amps at a voltage of about 630 V dissipating about 630 kW.", "Coil 5b comprises about 224 turns of hollow square 6 mm×6 mm copper wire carrying a current of about 1000 Amps at a voltage of about 832 V dissipating about 830 kW.", "Coil 5c comprises about 552 turns of hollow square 6 mm×6 mm copper wire carrying a current of about 1000 Amps at a voltage of about 844 V dissipating about 840 kW.", "In some embodiments, the coils 5a, 5b, and 5c will run substantially continuously during operation of the system.", "In some embodiments, a cooling system (not shown) provides water (or another coolant), which flows in the hollow wires to cool them.", "In certain implementations of the system, it is desirable to introduce gas only between the outer electrode 7 and the formation electrode 14.In certain such implementations, the valves 3 open and close sufficiently rapidly to introduce the gas so that it is substantially confined between the electrodes 7 and 14.For example, at room temperature (e.g., about 20 C), the thermal velocity of the gas is about 900 m/s.", "If, for example, the distance between the electrodes 7 and 14 is about one meter, the gas could be injected for a duration of less than about 1 ms to provide gas for the generation of each compact toroid.", "In some implementations, Parker Series 99 valves can be used (available from Parker Hannifin, Cleveland, Ohio).", "In some embodiments, the formation electrode 14 is electrically connected to a capacitor bank 1.In some such embodiments, the capacitor bank 1 can comprise a capacitance of about 4.1 mF and the bank can be charged at a voltage of about 22 kV.", "In some cases, the capacitor bank 1 comprises about eighty 52 μF individual capacitors (e.g., General Atomics Energy Products (San Diego, Calif.), model 33677 capacitors).", "The individual capacitors can be connected in parallel.", "The capacitor bank 1 can be connected to the formation electrode 14 using a transmission line.", "In some embodiments, the total inductance of the transmission line and capacitors is about 20 nF, which advantageously provides a sufficiently fast electric discharge.", "During operation of the system 1000, when the gas introduced by the puff valves 3 achieves a suitable pressure between the electrodes 7 and 14, the capacitor bank 1 discharges in the gas, turning the gas into a plasma.", "The discharge can occur when the capacitor bank voltage exceeds the breakdown voltage of the gas (which can depend on the gas pressure).", "In some implementations, the bank 1 discharges when the gas pressure is about 10 mTorr (e.g., about 1.3 Pa).", "The discharge can occur at other gas pressures in other embodiments.", "In the embodiment shown in FIG.", "1A, a switch 2 is activated to discharge the capacitor bank 1 through the gas, generating a plasma.", "A possible advantage of embodiments using the switch 2 is that the switch can be activated so that the discharge occurs when the gas is at a desired pressure, which may allow increased flexibility during operation.", "The current rises (e.g., to about 3 MAmp in about 20 μs in some cases), and the magnetic field from this current forces the plasma in the downward direction in FIGS.", "1A-1C, toward the plasma accelerator 110.The stuffing magnetic flux from the coils 5 wraps itself around the plasma.", "The magnetic field reconnects to form closed magnetic surfaces, and the plasma forms a compact toroid.", "For example, the toroid may be a spheromak 16 having a relatively low density (e.g., about 1015 cm−3, in some cases) and temperature (e.g., about 20 eV, in some cases).", "In some implementations of the system 1000, after a relatively small delay (e.g., about 30 μs, in some cases) to allow the magnetic fields to reconnect and/or to allow turbulence, if present, to settle, the spheromak 16 is accelerated and compressed by the plasma accelerator 110 toward the liquid metal funnel system 120.For example, in the embodiments schematically illustrated in FIGS.", "1A-1D, acceleration electrodes 6 are connected to a second capacitor bank 11, which is used to provide energy to the plasma.", "In some embodiments, the capacitor bank 11 has a capacitance of about 2.6 mF and is charged at a voltage of about 88 kV.", "In some such embodiments, the capacitor bank 11 comprises about 100 pairs of 52 μF, 44 kV individual capacitors with each pair electrically connected in series, and the 100 pairs electrically connected in parallel.", "In some embodiments, the capacitors comprise General Atomics Energy Products (San Diego, Calif.), model 32283 capacitors.", "In some implementations, the capacitor bank 11 is electrically connected to the acceleration electrode 6 using a substantially disk-shaped transmission line 15 substantially surrounding the coaxial gun 100 to reduce or minimize inductance.", "The current rise-time of some embodiments is about 40 μs because of the relatively large capacitance of the bank 11.In some embodiments, a substantially disk-shaped transmission line can be used to electrically connect the capacitor bank 1 to the formation electrode 14.In some embodiments, two substantially disk-shaped transmission lines are used: a first substantially disk-shaped transmission line electrically connecting the capacitor bank 1 to the formation electrode, and a second substantially disk-shaped transmission line electrically connecting the capacitor bank 11 to the acceleration electrode 6.The plasma accelerator 110 comprises a plasma propagation channel 114 through or along which the toroidal plasma 16 is accelerated.", "For example, as schematically illustrated in FIGS.", "1A-1D, the acceleration electrode 6 can be disposed within the outer electrode 7, and the plasma propagation channel 114 comprises space between the electrodes 6 and 7.The plasma propagation channel 114 can have a cross-section (perpendicular to the longitudinal axis 115) that changes (in shape, size, width, spacing, and/or any other way) from a first end 112a to a second end 112b of the accelerator.", "For example, in the embodiments illustrated in FIGS.", "1A-1D, at least one of the electrodes 6 and 7 can be tapered from the first end 112a of the accelerator 100 (e.g., near the plasma gun 100) to the second end 112b of the accelerator 100 (e.g., near the funnel system 120).", "For example, in some embodiments, the radius of the accelerator 110 (e.g., a radius from the longitudinal axis 115 to the center of the channel 114) decreases by a factor of about 30 from the first end 112a to the second end 112b.", "In other embodiments, the radius of the accelerator 110 decreases from the first end to the second end by a factor of about 2, about 5, about 10, about 20, about 50, about 100, or some other factor.", "In various embodiments, the radius decrease of the accelerator from the first end to the second end can be in a range from about 10 to about 50, in a range from about 20 to about 40, or some other range.", "With further reference to the embodiments schematically illustrated in FIGS.", "1A-1D, the magnetic force of the plasma accelerator 110 accelerates the toroidal plasma 16 between the tapered coaxial electrodes 6 and 7 and heats and compresses the plasma to higher temperature and density, forming a compressed toroidal plasma 12.The configuration of the electrodes 6, 7 can be selected to provide a desired amount of compression as the plasma moves from the first end 112a to the second end 112b of the accelerator 110.For example, one or more factors including the tapering, shape, and/or spacing of the electrodes 6, 7 can be selected to provide a desired compression.", "In the case of some toroidal configurations of plasma (e.g., compact toroids), the compression of the plasma in some implementations of the system 1000 can be measured in terms of a radial compression of the toroid (e.g., a ratio of the radius of the toroid when in a first position in the system to the radius of the toroid when in a second position in the system).", "For example, in some embodiments, the radial compression of the plasma as the plasma moves from the first end 112a to the second end 112b of the accelerator 110 is about 30:1.The radial compression of the plasma in the accelerator 110 can be different in other embodiments such as, for example, about 2:1, about 5:1, about 10:1, about 15:1, about 20:1, about 30:1, about 50:1, about 100:1, etc.", "In various embodiments, the compression of the plasma in the accelerator 110 can be in a range from about 10:1 to about 50:1, in a range from about 20:1 to about 40:1, or in some other appropriate range.", "In some embodiments, tapering of the electrodes 6, 7 is not used in the accelerator 110, and there is substantially no compression of the plasma in the accelerator 110.In other embodiments, the plasma accelerator 110 may be configured so that the outer electrode 7 acts as the acceleration electrode.", "In other embodiments, both electrodes 6 and 7 can be used to electromagnetically accelerate the plasma from the first end to the second end.", "In other embodiments, additional electrodes can be used (e.g., to assist stabilizing the plasma and/or to inhibit tilting of the toroid in the channel 114).", "The electrodes 6, 7, and/or 14 can be formed from electrically conductive metal.", "The electrodes 6, 7, and/or 14 can be formed in one or more sections.", "For example, in some embodiments, the electrodes 6, 7, and/or 14 comprise one or more stainless steel 304 plates or sheets having a thickness of about 5 mm.", "The sections of the electrodes can be joined together by welding, fasteners (e.g., bolts), etc.", "In other embodiments, the electrodes can be formed from additional and/or different materials and/or thicknesses of material.", "In some implementations, the plasma can become sufficiently hot to at least partially vaporize some of the electrodes.", "Vaporization of the electrode may in some cases contaminate the plasma with metallic impurities that can cool down the plasma.", "Therefore, in certain implementations that utilize electrodes that can (at least partially) vaporize, one or more of the electrodes 6, 7, and 14 can be coated with a high melting point material such as, e.g., tungsten.", "The coating material can be selected so that the melting point of the coating material (e.g., tungsten) is greater than the melting point of the electrode material (e.g., stainless steel).", "For example, in some implementations, tungsten is plasma sprayed on the electrode material (e.g., stainless steel 304).", "For example, Flamespray Northwest in Seattle, Wash., provides plasma spraying services.", "In other embodiments, the high melting point material can be layered or deposited on the electrode.", "In other embodiments, the electrodes are formed from the high melting point material.", "During the current rise time, the plasma will accelerate as it moves in the plasma propagation channel 114 (e.g., the space between the acceleration electrode 6 and the outer electrode 7) toward the liquid metal funnel system 120.In some implementations, the plasma accelerates for a distance of about 20 m and then for another distance of about 20 m or so to finish discharging the capacitor bank 11.In such embodiments, the total length of the plasma accelerator 110 is about 40 m. Different lengths of the plasma accelerator are possible.", "For example, the voltage on the capacitors in the bank 11 can be increased while the capacitance of the bank 11 is reduced, thereby maintaining the energy stored in the capacitor bank 11.This can reduce the current rise time and length of the accelerator 110.Use of higher voltage in some implementations may have possible disadvantages such as being technologically challenging and expensive.", "In some embodiments, the plasma accelerator 110 comprises a plasma restrictor 23.The length of an embodiment of the accelerator 110 comprising a plasma restrictor can be less than the length of an accelerator embodiment that does not comprise a plasma restrictor.", "In the embodiment shown in FIG.", "1B, the plasma restrictor 23 is disposed near the first end 112a of the accelerator 110, for example, below the first end 112a.", "As the current to the electrodes 6 and/or 7 increases, the magnetic field of the plasma accelerator 110 is initially insufficient to force the plasma past the restrictor 23.Movement of the plasma along the propagation channel 114 is inhibited.", "The system can be configured such that as the magnetic field of the accelerator 110 increases (e.g., as the current and/or voltage supplied to the electrodes 6 and/or 7 increases), the magnetic field increases and reaches a threshold value at which the magnetic force is sufficient to force the plasma past the restrictor 23.The plasma then accelerates along the propagation channel 114.For example, the system may be configured such that at (or near) peak current the magnetic force is sufficient to push the plasma through the restrictor 23 and to start the plasma accelerating down the plasma accelerator 110.In some embodiments, the plasma restrictor 23 comprises a constriction in the plasma propagation channel 114.For example, the constriction may comprise a narrowing of the space between the acceleration electrode 6 and the outer electrode 7.In some embodiments, the constriction is provided by disposing one or more structures 23a in the plasma acceleration channel 114 (see, e.g., FIG.", "1B).", "In other embodiments, the constriction in the plasma channel 114 is provided by shaping the outer electrode 7 and/or the acceleration electrode 6 so that the channel 114 narrows at the location of the constriction.", "The location, shape, size, spacing, and/or number of constrictions (e.g., structures disposed in or along the channel 114 or narrowings of the channel 114) disposed along the propagation channel 114 can be selected to provide a desired amount of restriction against movement of the plasma along the channel 114.In some such implementations, an accelerator length of about 10 m can be used to transfer the energy from the capacitor bank 11 to the plasma using an 88 kV capacitor voltage.", "In other embodiments, the plasma restrictor 23 can be configured differently than the constriction schematically illustrated in FIG.", "1B.", "For example, FIG.", "1C schematically illustrates an embodiment in which the plasma restrictor 23 comprises one or more magnetic coils 23b disposed near the first end 112a of the accelerator 110.When a current is supplied to the one or more magnetic coils 23b, the coils 23b provide a restricting magnetic force than inhibits movement of the plasma toroid past the position of the coils until the magnetic force produced by the accelerator 110 is above a threshold.", "In some embodiments, the current to the coils 23b can be reduced (or switched off) to reduce (or substantially eliminate) the restricting magnetic field in order to permit the plasma toroid to accelerate toward the second end 112b of the accelerator 110.In some embodiments, a combination of the increase in the magnetic force provided by the accelerator 110 and the reduction of the restrictive magnetic force provided by the coils 23b permits the plasma to accelerate along the channel 114 at an appropriate time.", "In some embodiments, the magnetic field produced by the coils 23b is sufficient to inhibit acceleration of the toroidal plasma along the channel 114, even at maximum current in the accelerator 110.In such embodiments, the current to the coils 23b is reduced (or switched off) to release the toroidal plasma at a desired time.", "In some embodiments, the plasma restrictor 23 can comprise one or more constrictions 23a and one or more coils 23b After the plasma is formed, the plasma electrically contacts the outer electrode 7 and the acceleration electrode 6.This contact can short circuit the acceleration capacitor bank 11 and start current flowing through the plasma.", "As discussed above, it may be desirable in some implementations to delay the acceleration (e.g., for about 30 μs, in some cases) to allow the closed magnetic surfaces to form and/or for turbulence, if present, to settle.", "In some such implementations, a saturable inductor 17 (see, e.g., FIG.", "1B) is used to delay the voltages provided to the electrodes.", "The saturable inductor 17 can be disposed in transmission line 15.The saturable inductor 17 may comprise a saturable magnetic material.", "For example, an amorphous metal such as, e.g., METGLAS 2605Co (available from Metglas Inc., Conway, S.C.) can be used.", "To provide a delay of about 30 μs at a voltage of about 88 kV the inductor 17 can store about 88 kV multiplied by 30 μs=2.6 V·s.", "In some embodiments, the inductor 17 is substantially toroidal with a cross-section of about 0.6 m2 and a major radius of about 1 m. In some embodiments, the inductor 17 comprises Metglas wound tape with a saturation field of about 1.8 Tesla to provide an appropriate delay.", "In the embodiments schematically illustrated in FIGS.", "1A-1D, the system is configured so that at or before the point where the pressure of the plasma builds so that it could exceed the break point or strength of the material or the assembly comprising the electrodes 6 and/or 7 (or other components of the accelerator near the second end 112b), the plasma exits the accelerator 110 and enters the liquid metal funnel system 120.An advantage of some of these embodiments is that the pressure of the plasma in the accelerator is increased to a relatively large value without damaging the accelerator (e.g., due to yield failure and/or deformation of second end 112b of the accelerator 110).", "In the illustrated embodiments, the liquid metal funnel system 120 comprises a tank 10 and one or more pumps 9 configured to circulate the liquid metal to form a liquid metal funnel 8.The liquid metal flows from a top end of the funnel system 120 to a bottom end of the funnel system 120 under the influence of gravity.", "In some embodiments, the top end of the funnel system 120 is substantially above the bottom end of the funnel system 120.In some embodiments, the pumps 9 may provide a pressure to the liquid metal, which may also influence the flow of the liquid metal in the tank 10.In some implementations, the funnel 8 has a substantially cylindrical shape having a passage 125 that is substantially aligned with a longitudinal axis of the plasma accelerator 110.The cross-section of the passage 125 (perpendicular to a longitudinal axis of the passage 125) may be substantially circular, substantially oval, substantially polygonal, or any other shape.", "The cross-sectional shape (and/or size) of the passage can change from the top end to the bottom end.", "For example, the cross-sectional area at the bottom end may be less than the cross-sectional area at the top end.", "The passage 125 may have an inner surface having an inner diameter.", "The cross-section of the inner surface can be substantially circular, substantially oval, substantially polygonal (e.g., rectangular), or any suitable shape.", "The inner diameter at the bottom end can be less than the inner diameter at the top end.", "The cross-sectional shape, size, and/or the inner diameter of the passage can be configured to provide a desired amount of compression for the plasma as it moves below the top end.", "For example, in some embodiments, the inner diameter of the passage 125 at the bottom end is about a factor of 3 smaller than the inner diameter of the passage 125 at the top end.", "The ratio of the inner diameter of the passage at the top end to the inner diameter of the passage at the bottom end can be about 1.5, about 2, about 4, about 5, about 10, about 15, or greater.", "This ratio can be in a range from about 1.5 to about 5, from about 2 to about 4, or some other range.", "In some embodiments, the plasma may move from the top end to the bottom end of the passage.", "In other embodiments, the plasma pressure may become sufficiently large during movement of the plasma along the channel that the plasma may disrupt the funnel 8 before the plasma reaches the bottom end of the passage.", "In certain embodiments, the liquid material comprising the liquid funnel 8 does not substantially rotate around an axis of the passage.", "In other embodiments, the liquid material can be introduced into the tank 10 so that the liquid material rotates around the axis of the passage as the liquid material moves from the top end to the bottom end.", "Funnels in which the liquid material possesses some amount of rotation (or swirling) may provide advantages in some implementations such as, e.g., increasing stability of the inner surface of the passage.", "Because the plasma can move at a speed (e.g., about several tens of km/s, or higher, in some cases) that is higher than the speed of sound in the liquid metal (e.g., about 3 km/s, in some cases), the liquid metal does not have time to move out of the way as the plasma moves through the liquid funnel system 120 (e.g., the inertia of the liquid metal funnel at least partially confines the plasma).", "The liquid metal therefore tends to act as if it were a solid to the plasma and can act to confine the plasma in the passage 125 of the funnel 8.The plasma can experience compression (and heating) in the funnel 8 as the plasma moves from the top end of the funnel 8 to the bottom end of the funnel 8.For example, a pressure of the plasma when the plasma is below the top end of the funnel 8 can be greater than a pressure of the plasma when the plasma is above the top end of the funnel 8.FIGS.", "1A-1C schematically illustrate the compressed plasma toroid 13 in the funnel 8.The radial compression of the plasma in the passage 125 of the funnel 8 can be about 3:1 (or greater) in some implementations.", "In other implementations, the radial compression of the plasma can be about 1.5:1, about 2:1, about 4:1, about 5:1, about 7:1, about 10:1, about 15:1, or greater.", "The radial compression of the plasma in the passage 125 of the funnel 8 may be in a range from about 1.5:1 to about 5:1, from about 2:1 to about 4:1, or some other range.", "In certain implementations, a desired total radial compression of the plasma measured between the first end of the accelerator 110 and the final position of the plasma in the funnel 8 (e.g., when the plasma pressure becomes sufficiently large to disrupt the funnel) can be about 200:1, about 150; 1, about 100:1, about 90:1, about 75:1, about 50:1, about 30:1, about 20:1, about 10:1, or some other value.", "The total radial compression can be in a range from about 50:1 to about 150:1, from about 75:1 to about 125:1, about 80:1 to about 100:1, or some other range.", "In some implementations, the desired total radial compression of the plasma toroid (e.g., from the first end 112a of the accelerator 110 to the final position of the plasma in the funnel 8) can be achieved by configuring the system 1000 to have a first compression ratio in the accelerator 110 and to have a second compression ratio in the funnel 8 such that the first compression ratio multiplied by the second compression ratio equals the desired total compression ratio.", "For example, to achieve a total compression of about 90:1, the accelerator 110 can be configured to provide a first compression ratio of about 30:1 and the funnel 8 can be configured to provide a second compression ratio of about 3:1.These ratios are not limitations on the disclosed systems and methods, and continuing with this example, a total compression ratio of 90:1 can be achieved differently in different implementations of the system 1000, e.g., about 45:1 in the accelerator and about 2:1 in the funnel, about 18:1 in the accelerator and about 5:1 in the funnel, and so forth.", "In some embodiments, the first compression ratio in the accelerator 110 is selected so that a pressure of the plasma at the second end 112b of the accelerator is at or below the material strength or breakpoint of the materials or assemblies of materials at the second end 112b of the accelerator 110.In some implementations, the accelerator 110 can be configured to provide a desired first compression ratio more readily than the liquid funnel can be configured to provide a desired second compression ratio.", "In some such implementations, it may be advantageous for the accelerator 110 to provide more compression than the funnel 8 (e.g., the first compression ratio is larger than the second compression ratio).", "The liquid funnel 8 can comprise a suitable liquid metal such as, for example, molten lead-lithium (PbLi) with about 17% lithium (Li).", "Other lithium percentages can be used in other embodiments (e.g., 0%, 5%, 10%, 15%, 20%, 25%, etc.).", "Also, other liquid materials (e.g., other liquid metals, liquid metal alloys, etc.)", "can be used in other embodiments.", "For example, in other embodiments, substantially pure liquid lithium and/or enriched liquid lithium can be used.", "In some embodiments, the liquid metal comprises one or more lithium isotopes, which can absorb neutrons and produce tritium.", "In some implementations of a system in which the plasma comprises a fusionable material, the plasma can be compressed to a density and/or temperature sufficient to initiate at least some thermonuclear reactions in the fusionable material.", "The thermonuclear reactions may produce neutrons.", "Some of the neutrons may be used for neutron analysis if the system is configured, e.g., as a neutron source.", "Some of the neutrons may be absorbed by, e.g., the liquid metal funnel 8 and their energy converted to heat in the molten funnel.", "Some of this heat may be extracted to produce electrical power (e.g., via steam turbines) if the system is configured, e.g., as an energy source.", "During or after passage of the plasma through the funnel 8, the liquid metal funnel 8 generally is at least partially disturbed and/or destroyed (e.g., the liquid metal splashes outwards but is contained by a tank 10).", "The pumps 9 circulate liquid metal into the tank 10 to re-form the liquid metal funnel 8 for subsequent injections (or shots) of the plasma.", "Accordingly, embodiments of the system schematically illustrated in FIGS.", "1A-1D may be configured to act as a pulsed source of neutrons and/or energy as plasma toroids are repeatedly introduced into the liquid metal funnel 8.In some embodiments (see, e.g., FIGS.", "1B-1D), in addition to the liquid metal funnel 8, the liquid funnel system 120 comprises a substantially central or axial liquid guide 22.For example, the liquid guide 22 can be substantially aligned with the longitudinal axis 115 of the accelerator 110 and/or the axis of the passage 125.The liquid guide 22 can be configured to stabilize and/or reduce a tendency for tilting of the plasma torus in the funnel system 120.In some embodiments, the liquid guide 22 is supplied by liquid metal from a liquid metal storage tank or reservoir 18.The storage tank 18 is disposed between the acceleration electrodes 6 in some embodiments.", "In the embodiment shown in FIG.", "1B, the liquid guide 22 flows at least partially under gravity toward the bottom of the tank 10, and a pump 21 can be used to recirculate the liquid metal back into the storage tank 18 for reuse.", "In some such embodiments, it is advantageous if the liquid metal used for the funnel 8 and the liquid metal used for the liquid guide 22 comprise the same material, because of the likely mixing of the liquid metal of the guide 22 and the liquid metal of the funnel 8 in the tank 10.For example, the liquid metal for the liquid guide 22 can comprise molten PbLi.", "In some such embodiments, the plasma is compressed between the inner surface of the funnel 8 and the outer surface of the liquid guide 22, which advantageously may provide a larger amount of compression than embodiments not using a liquid guide 22.The size and/or shape of the funnel 8 and/or the liquid guide 22 can be configured to provide a desired amount of compression and/or heating for the plasma as the plasma moves below the top of the liquid metal funnel system 120.The liquid guide 22 may be physically and/or electrically isolated from the liquid funnel 8 (and/or the tank 10) in various embodiments.", "An advantage of some embodiments of the system that use a liquid guide 22 is that the liquid metal is electrically conductive and acts like a substantially central or axial electrode.", "In some such embodiments, the electrical current from the plasma accelerator 110 can continue to provide a magnetic (and/or electromagnetic) force that pushes on the plasma to provide further compression.", "Accordingly, some such embodiments can provide additional compression compared to certain embodiments not comprising the liquid guide, in which compression in the funnel 8 is provided primarily by the momentum of the plasma.", "In certain embodiments, the liquid guide 22 is electrically isolated from the outer electrode 7, to reduce the likelihood of or avoid shorting the electrical circuit.", "In certain such embodiments, the liquid guide 22 is not provided continuously into the tank 10.For example, the liquid funnel system 120 may comprise a liquid guide injection system that injects the liquid guide 22 into the passage of the funnel 8 at desired times.", "For example, the liquid guide injection system can comprise a pulse valve 20 that can be opened shortly before a plasma shot.", "The plasma shot can be fired before the lower end of the liquid metal in the liquid guide 22 contacts the bottom of the tank 10 (or contacts liquid metal at the bottom of the tank 10), because such contact is likely to complete the electrical circuit.", "After each shot, the pump 21 (e.g., an intermittent pump) recirculates some of the liquid metal in the tank 10 to the storage tank 18.In some embodiments, the pump 21 operates to refill the storage tank 18 when the acceleration electrode 6 is not at a high voltage (e.g., between shots of plasma).", "In some embodiments, a portion of the recirculation plumbing (e.g., a return pipe 31) used for recirculating the liquid metal into the tank 18 comprises an electrically insulated section 19 (see, e.g., FIGS.", "1B and 1C).", "The insulator section 19 can be oriented substantially vertically to permit drainage of residual liquid metal after refilling of the storage tank 18 to reduce the likelihood of short circuiting the acceleration electrode 6.In some embodiments, the space above the fluid in the storage tank 18 is pressurized (e.g., at a pressure of about 30 psi, in some cases) (e.g., about 2.07×105 Pa) with an inert gas such as, e.g., argon.", "The pressurized inert gas provides a downward force on the liquid in the storage tank 18 that (in combination with gravity) allows the liquid metal to be ejected at a desired speed.", "Example Magnetized Target Fusion Applications The following discussion is intended to give illustrative, non-limiting examples of certain parameters of an embodiment of a system that could be used to achieve certain plasma compression values.", "Various assumptions are discussed in the context of these examples, and various equations and example calculations are provided herein to highlight some of the factors and considerations involved in an example embodiment of a system for compressing a plasma.", "The following discussion is not intended to limit the scope of the systems and methods described herein, nor end-uses or applications of the disclosed systems.", "In other implementations of the systems and methods described herein, other equations, parameters, factors, and considerations may be applicable.", "Magnetized Target Fusion (MTF) systems typically use significant energy (e.g., about 100 MJ in some cases) to compress the plasma.", "For generating fusion energy in many systems, the well-known Lawson criteria indicates that a plasma of density n, maintained at a temperature of 10 keV, for a time t, should be selected so that nτ>1020 m−3 s for fusion heating to exceed plasma heat losses.", "However, the plasma cools down with a time τ=r2/χ where r is the smallest distance between the hot plasma core and the cold edge of the reactor, and χ is the diffusivity.", "Therefore, a larger plasma (e.g., larger r) may be beneficial but uses more energy for its formation, and generally therefore a larger and more expensive apparatus.", "The energy in the plasma is 3/2 NkTi for the ions and 3/2N kTe for the electrons, where Ti is ion temperature, Te is electron temperature and N is the number of ions or electrons.", "The number of ions and electrons is equal in the case of overall charge neutrality.", "Assuming Ti and Te are the same temperature, then the thermal energy (Eth) in the plasma is 3NkT.", "Thus, the following equations are applicable for providing estimates for example parameters in certain embodiments of the system: nτ>1020 m−3s τ=r2/χ Eth=3VnkT with N=nV, where V is plasma volume, and Emag=Eth/β where β is the ratio of plasma pressure/magnetic pressure.", "The total energy is the thermal energy Eth plus the magnetic energy Emag.", "For a torus, the volume is 2π2r2R where R is the major radius (around the torus) and r is the minor radius.", "For a compact torus R is approximately equal to r so the volume can be approximated as 2π2r3.Combining these equations it is found that the minimal energy to reach the Lawson criterion at 10 keV temperature in some system embodiments is about: E=7×1016(1+1β)χ3/2n−1/2 Joules with n in m−3 and χ in m2/s.", "The energy E decreases with increasing density and decreases with decreasing χ. Diffusion and the value of χ in these systems is a subject of much research.", "The value of diffusion in some systems is much larger than a so-called classical calculation because of complex turbulence.", "Classical estimates for the value of diffusion generally provide the best possible diffusion.", "Many experiments observe a diffusion much larger than classical, but less than the so-called Bohm diffusion where: χBohm=ρiv1/16 where ρi is the ion gyroradius and vi is the ion thermal velocity.", "Assuming Bohm diffusion (as a worst case example scenario), the minimal plasma energy to achieve the Lawson criterion for various plasma densities (e.g., at 10 keV and β=0.1 typical of certain spheromaks) can be predicted from the above equations for the above example system and is shown in the graph illustrated in FIG.", "2 (solid line with diamonds).", "The magnetic pressure of a plasma at a temperature of 10 keV, β=0.1 at various densities is also plotted on the graph shown in FIG.", "2 (solid line with squares).", "The maximum pressure that solid material can take before breaking is typically about 1×104 atm (e.g., about 1000 MPa).", "At that pressure, the example calculations shown in FIG.", "2 indicate the example system should provide about 100 MJ in the plasma to achieve break-even, and possibly a few times more than that energy for a practical gain.", "Assuming a transfer efficiency from the power source to the plasma of about 50%, the system should provide at least about 200 MJ of energy to heat the plasma to a fusion temperature.", "Embodiments of the disclosed system configured as an energy source may provide advantages.", "For example, using a liquid metal funnel can allow pressures in the plasma to be achieved that are above the breaking point of solid materials.", "Therefore, embodiments of the disclosed systems may provide increased plasma density, which advantageously reduces the energy used by the system.", "This may also reduce the cost and/or size of the system.", "In some embodiments of the present systems and methods, the plasma pressure increases as the plasma is accelerated and then compressed as the plasma moves down the accelerator 110 (e.g., along the propagation channel 114 between the coaxial tapered electrodes 6, 7).", "At or before the point along the plasma path where the plasma pressure meets and/or exceeds the strength of the confining electrode material, the plasma is directed into the liquid metal funnel system 120 in which further compression occurs.", "For example, the plasma compression can be about a factor of 30 in the accelerator and about a factor of 3 in the funnel system.", "In some embodiments, the plasma can be accelerated to a speed greater than about 100 km/s down the accelerator 110.The speed of sound in the liquid metal is generally of the order 3 km/s, so the liquid metal does not have time to move out of the way, and a high plasma pressure is maintained in the funnel 8.In some implementations, a shock wave wake may be generated in the liquid metal.", "The energy in the shock wave wake is drawn from the plasma kinetic energy; which can be a new energy loss mechanism in some such embodiments.", "FIG.", "3 is a schematic cross-sectional diagram showing an example of a toroidal plasma 30 moving within a portion of a tapered liquid metal funnel 25.Assuming a plasma speed vp and plasma length L, and a liquid metal with a sound speed of cs, the schematic diagram in FIG.", "3 shows a shock wave trailing behind the plasma.", "The thickness of the shock wave is about csL/vp.", "In a time of about L/vp (e.g., the time for the plasma to travel its own length), the volume of the compressed liquid in the funnel is about 2πRLcs·L/vp.", "Dividing the compressed volume by the time gives an estimate for the rate at which liquid metal is compressed: dV/dt=2πRLcs m3/s where R is the radius of the liquid metal funnel 25.As an example, a simple approximate formula for the equation of state for the liquid metal can be used: P=K(V0/V−1) where K is the volume compression modulus and V0 is the initial volume at zero compression.", "Accordingly, the compression work, PdV, can be integrated to calculate the energy stored in the compressed liquid metal in this example: E/V=K[ln(P/K+1)−1/(1+K/P)] J/m3 The power dissipated in the wake is given by the following formula in this example: Power=2πRLcsK[ln(P/K+1)−1/(1+K/P)] Watts In some implementation, electrical currents may be induced in the liquid metal by the magnetic field of the spheromak.", "Resistive losses in the liquid metal may reduce the energy in the magnetic field that contains the plasma, representing another possible energy loss mechanism in some cases.", "The following illustrative example is used to provide an estimate for this energy loss mechanism.", "The current I flowing in the liquid metal to support the magnetic field is: I=LB/μ0 where L is the length of the plasma, B is the magnetic field in the spheromak (or other suitable compact torus) and μ0 is the vacuum permeability.", "The thickness t of the sheet of electric current flowing in the metal is given by: t=(ητ/μ0)1/2 where η is the electrical resistivity of the metal and τ is the time during which the magnetic field is applied to the metal and where τ=L/vp The resistance is as follows: Resistance=η2πR/Lt Thus, the power dissipated Ohmically in the liquid metal is: Power=Resistance I2=2πRB2(ηLvp)1/2μ0−3/2 Watts In some implementations, there also may be power losses due to turbulent transport.", "An estimate for such power losses, using the Bohm diffusion formula, is: PowerBohm=Eth/τBohm Bremsstralung radiation losses may occur in some cases and an estimate for such losses is given by: POwerBremsstralung=1.67×10−38n2T1/2Zeff W/m3 where T is in eV and n is in m−3 and Zeff=ΣZ2nz/n where Z is the atomic number of the impurity and nz is its density.", "The Bremsstralung radiation power losses are a function of the square of the impurity atomic number Z, so having a low impurity content can be advantageous in some cases, especially for impurities with high atomic numbers.", "Continuing with this illustrative, non-limiting example calculation, dividing the energy in the plasma configuration by these various power losses gives a total plasma confinement time τ.", "Using that confinement time it is possible to calculate the minimum plasma energy to achieve a Lawson break-even condition at various densities for this example embodiment of the system.", "The energy for this embodiment is shown in the graph of FIG.", "4.Note that the energy used may be more than indicated by the example graph in FIG.", "2 in some implementations, because energy loss mechanisms particular to the above example embodiment have been taken into account.", "The graph in FIG.", "4 shows that an example estimate for the minimum plasma energy used is about 3 MJ at an example density of 1019 cm−3.Compare this to the example results shown in FIG.", "2 that indicate less than about 1 MJ at this example density.", "The plasma outer radius R is 2.4 cm in this example calculation.", "The confinement time is 10 μs in this example calculation.", "The magnetic field is 200 Tesla, and the pressure is 0.16 Mbar, in this example calculation.", "A possible value for the speed of the plasma during maximum compression is just above the speed of sound, for example, about 5 km/s.", "Based on these example values, the plasma moves only about 50 mm during the time where the plasma temperature and pressure conditions could allow fusion to occur.", "As discussed above, during and/or after the passage of the plasma, the liquid metal funnel may tend to be outwardly disrupted in some implementations of the system.", "In some such implementations, the system can be configured so that the liquid metal funnel will reform after a time Lfe/vf where Lfe is the length of the funnel and vf is the speed at which the liquid is expelled from the nozzles (that input liquid metal into the tank 10 of the funnel system 120).", "These parameters can be used to determine an example estimate for the maximum pulse repetition rate in such an embodiment.", "In this illustrative, non-limiting example, about 1 m of the liquid metal is used to absorb most of the neutrons so, for example, a 2 m long liquid metal funnel, where the plasma temperature and pressure conditions are suitable for fusion to occur in the center, would be appropriate for some embodiments.", "Assuming vf is approximately 10 m/s, the repetition rate could be about 5 Hz in this example.", "Finally if the net energy out is of the order of the energy in, the plasma will produce approximately 3 MJ at 5 Hz yielding a power output of approximately 15 MW, which is suitable for a small power plant.", "Note that these estimates provide one possible estimate for the size of a power plant producing break-even in this example, and a larger plant may provide more power but may cost more to develop and build.", "Continuing with this illustrative, non-limiting example, working from the conditions at maximum compression and assuming that some plasma guns 100 typically produce plasma densities not much in excess of about 1014 cm−3, the initial plasma formation at the first end 112a of the plasma accelerator 110 would be about 2.2 m in diameter in order to provide the final 2.4 cm radius compressed plasma with a density of about 1019 cm−3.The length of the plasma formation initially will be about 1 m, so this is about the length estimated for the formation region in this example implementation.", "Therefore, the ratio of the radial size of the compact toroid at the first end 112a of the accelerator 110 to the radial size of the compact toroid when the toroid is in the liquid metal funnel 8 is about 100 to 1 in this example.", "In other embodiments, this ratio can be different such as, for example, about 5:1, about 10:1, about 25:1, about 50:1, about 90:1, about 125:1, about 150:1, about 200:1, or some other value.", "Assuming, for example, about 33% efficiency of energy transfer between the capacitors and the plasma, about 10 MJ will be used in this example.", "Typical fast discharge foil capacitors have an energy density of about 1 J/cm3, so about 10 m3 of capacitor volume is used in this example.", "Assuming the capacitors are 1 m high and are packed on both sides of a disk-shaped transmission line 15 associated with the plasma accelerator, a disk of about 2.2 m inside diameter and 2.6 m outside diameter is used in this example.", "In some embodiments, this disk transmission line plus internal inductance of the capacitors have an inductance of about 20 nH.", "The inductance of the plasma accelerator is about 130 nH in some implementations.", "Generally, the higher the voltage in the capacitor, the faster the discharge.", "Assuming a voltage of about 88 kV, the capacitor bank can have a capacitance of about 2.6 mF.", "In such an example implementation, the system will have an LC ringing time of about 100 μs.", "In one example implementation, for reasonable energy transfer to occur, half the ringing time (e.g., about 50 μs) should be approximately equal to the time for the plasma to accelerate down the accelerator.", "The final velocity advantageously can be high enough so the kinetic energy of the plasma is high enough to compress itself in the liquid metal funnel to maximum compression.", "Equating the example energy found above to the kinetic energy: 3MJ=mv2/2 The mass of the plasma is its volume times the density and is about: m=2 milligrams Accordingly, in this example, a final speed of the plasma is about 1700 km/s.", "In order for the transit time of the plasma to equal half the ringing time, an accelerator length of about 40 m can be used in some cases.", "The length of the accelerator can be advantageously reduced by using a plasma restrictor at or near the first end 112a of the accelerator 110 (see, e.g., the constriction shown in FIG.", "1B or the magnetic coils 23b shown in FIG.", "1C).", "As the current increases, limited by the inductance, the plasma is unable to pass trough the constriction.", "In some embodiments, the system is configured such that only at or near peak current is the magnetic force strong enough to force the plasma through the constriction and rapidly accelerate the plasma.", "In some such embodiments, because the plasma starts accelerating only at (or near) peak current, an accelerator that is only about ¼ the length (e.g., about 10 m, in some cases) can be used.", "This would provide a reasonable, practical, realistic implementation of a system for compressing plasma and, in some cases, initiating fusion reactions.", "Implementations of such a system may have other uses as well.", "Other Example Embodiments and Useful Applications As discussed above, certain embodiments of the above-described systems and methods can be used to compress a plasma that comprises a fusionable material sufficiently that fusion reactions and useful neutron production can occur.", "For example, the fusionable material may comprise one or more isotopes of light elements such as, e.g., deuterium, tritium, helium-3, lithium-6, lithium-7, etc.", "Accordingly, certain embodiments of the system may be configured and operated to act as neutron generators or neutron sources.", "Neutrons so produced have a wide range of practical uses in research and industrial fields.", "For example, a neutron source can be used for neutron activation analysis (NAA) which can provide multi-element analysis of major, minor, trace, and rare elements in a variety of substances (e.g., explosives, drugs, fissile materials, poisons, etc.)", "and can be used in a variety of applications (e.g., explosive detection and identification, ecological monitoring of the environment and nuclear waste, etc.).", "Embodiments of the system configured as a neutron source can also be used for materials research (e.g., analyzing the structure, dynamics, composition, and chemical uniformity of materials), for non-destructive testing of industrial objects (e.g., via neutron radiography and/or neutron tomography), and for many other industrial and technological applications.", "For example, embodiments of the system may be used for nuclear waste remediation and generation of medical nucleotides.", "Embodiments of the above-described systems and methods for plasma heating and compression are also suited for applications in the study of high energy density plasma including, for example, applications in astrophysics and nuclear physics.", "Recent advances in energy storage (for example, supercapacitors) and high-power semiconductor switching have driven down the cost of high-power electrical components.", "Further developments in electrical pulse power systems and increasing demand for such components for a variety of applications is expected to make an electrically-driven MTF system (and/or neutron source) cost competitive with other approaches.", "In applications where cost is less of a factor (e.g., fusion space propulsion where a lower mass payload may be at a premium), embodiments of such an electrically-driven system may be already appealing compared to other possible technologies.", "In certain implementations of the systems and methods disclosed herein, achieving plasma compression based on an electrical rather than a mechanical approach (e.g., certain piston-based systems) can, in some cases, be expected to reduce system maintenance and offer other advantages.", "For example, in some such implementations, the acceleration system can be configured with fewer or no moving parts and can be of lower weight.", "In some embodiments, synchronization issues are simplified relative to certain embodiments of a piston-based system.", "While particular elements, embodiments, examples, and applications of the present disclosure have been shown and described, it will be understood, that the scope of the disclosure is not limited thereto, since modifications can be made by those skilled in the art without departing from the scope of the present disclosure, particularly in light of the foregoing teachings.", "Thus, for example, in any method or process disclosed herein, the acts or operations making up the method/process may be performed in any suitable sequence and are not necessarily limited to any particular disclosed sequence.", "Elements and components can be configured or arranged differently, combined, and/or eliminated in various embodiments.", "Reference throughout this disclosure to “some embodiments,” “an embodiment,” or the like, means that a particular feature, structure, step, process, or characteristic described in connection with the embodiment is included in at least one embodiment.", "Thus, appearances of the phrases “in some embodiments,” “in an embodiment,” or the like, throughout this disclosure are not necessarily all referring to the same embodiment and may refer to one or more of the same or different embodiments.", "Indeed, the novel methods and systems described herein may be embodied in a variety of other forms; furthermore, various omissions, additions, substitutions, equivalents, rearrangements, and changes in the form of the embodiments described herein may be made without departing from the spirit of the inventions described herein.", "Various aspects and advantages of the embodiments have been described where appropriate.", "It is to be understood that not necessarily all such aspects or advantages may be achieved in accordance with any particular embodiment.", "Thus, for example, it should be recognized that the various embodiments may be carried out in a manner that achieves or optimizes one advantage or group of advantages as taught herein without necessarily achieving other aspects or advantages as may be taught or suggested herein.", "Conditional language used herein, such as, among others, “can,” “could,” “might,” “may,” “e.g.,” and the like, unless specifically stated otherwise, or otherwise understood within the context as used, is generally intended to convey that certain embodiments include, while other embodiments do not include, certain features, elements and/or steps.", "Thus, such conditional language is not generally intended to imply that features, elements and/or steps are in any way required for one or more embodiments or that one or more embodiments necessarily include logic for deciding, with or without operator input or prompting, whether these features, elements and/or steps are included or are to be performed in any particular embodiment.", "No single feature or group of features is required for or indispensable to any particular embodiment.", "The terms “comprising,” “including,” “having,” and the like are synonymous and are used inclusively, in an open-ended fashion, and do not exclude additional elements, features, acts, operations, and so forth.", "Also, the term “or” is used in its inclusive sense (and not in its exclusive sense) so that when used, for example, to connect a list of elements, the term “or” means one, some, or all of the elements in the list.", "The example calculations, results, graphs, values, and parameters of the embodiments described herein are intended to illustrate and not to limit the disclosed embodiments.", "Other embodiments can be configured and/or operated differently than the illustrative examples described herein." ] ]
Patent_15872585
[ [ "COMPOSITIONS AND METHODS FOR THE TREATMENT OF SLEEP APNEA", "The present invention features a novel therapy for effecting weight loss which involves treating a subject with a sympathomimetic agent (e.g., phentermine or a phentermine-like drug) in combination with an anticonvulsant sulfamate derivative (e.g., topiramate) such that the subject experiences weight loss.", "The combination methods of the present invention also are effective against symptoms associated with Syndrome X.", "The invention also features pharmaceutical compositions and kits use in the practice of these navel therapies." ], [ "1.A method for treating sleep apnea in a subject comprising administering to the patient a therapeutically effective amount of a carbonic anhydrase inhibitor comprising an anticonvulsant sulfamate derivative in combination with a therapeutically effective amount of a sympathomimetic agent.", "2.The method of claim 1, wherein the sympathomimetic agent is a substituted or unsubstituted aromatic amine.", "3.The method of claim 2, wherein the sympathomimetic agent is selected from phenylethylamine, epinephrine, norepinephrine, epinine, dopamine, dobutamine, nordefrin, ethylnorepinephrine, isoproterenol, protokylol, isoctharine, metaproterenol, terbutaline, metaraminol, phenylephrine, tyramine, hydroxyampbetamine, methoxyphenamine, methoxamine, albuterol, amphetamine, methamphetamine, benzphetamine, ephedrine, phenylpropanolamine, mephentermine, phentermine, chlorphentermine, fentluramine, propylhexedrine, diethylpropion, phenmetrazine, and phendimetrazine.", "4.The method of claim 3, wherein the sympathomimetic agent is phentermine.", "5.The method of claim 1, wherein the carbonic anhydrase inhibitor is a compound having the structure of formula (I) wherein X is CH2 or O, R1, R2, R3, R4, and R5 are independently H or C1-C4 alkyl, and further herein when X is O, then R2 and R3, and/or R4 and R5, may be taken together to form a methylene dioxy linkage of the formula —O—CR6R7—O— in which R6 and R7 are independently H or C1-C3 alkyl, or may be taken together to form a cyctopentyl or cyclohexyl ring.", "6.The method of claim 5, wherein X is O, R1 is H, R2 and R3 taken together form the methylene dioxy linkage —O—CH2—O—, R4 and R5 taken together form the methylene dioxy linkage —O—CH2—O—, and the carbonic anhydrase inhibitor is topiramate.", "7.The method of claim 1, wherein the carbonic anhydrase inhibitor and the sympathomimetic agent are administered simultaneously.", "8.The method of claim 7, wherein the carbonic anhydrasc inhibitor and the sympathomimetic agent are administered in a single pharmaceutical formulation.", "9.The method of claim 8, wherein the pharmaceutical formulation comprises a controlled release dosage form.", "10.The method of claim 9, wherein the controlled release dosage form provides for immediate release of the sympathomimetic agent and delayed release of the carbonic anhydrase inhibitor.", "11.The method of claim 10, wherein the controlled release dosage form further provides for sustained release of the carbonic anhydrase inhibitor.", "12.The method of claim 1, wherein the carbonic anhydrase inhibitor is topiramate and the sympathomimetic agent is phentermine.", "13.The method of claim 12, wherein the therapeutically effective amount of topiramate is from 5 mg to 1000 mg daily and the therapeutically effective amount of phentermine is in the range of about 5 mg to 60 mg daily.", "14.The method of claim 13, wherein the therapeutically effective amount of topiramate is at most about 400 mg daily.", "15.The method of claim 12, wherein the phentermine and the topiramate are administered simultaneously.", "16.The method of claim 15, wherein the phentermine and the topiramate are administered in a single pharmaceutical formulation.", "17.The method of claim 16, wherein the pharmaceutical formulation comprises a controlled release dosage form.", "18.The method of claim 17, wherein the controlled release dosage form provides for immediate release of the phentermine and delayed release of the topiramate.", "19.The method of claim 18, wherein the controlled release dosage form further provides for sustained release of the topiramate.", "20.The method of claim 18, wherein release of topiramate is delayed by 4 hours following release of phentermine.", "21.The method of claim 19, wherein release of topiramate is delayed by 8 hours following release of phentermine.", "22.The method of claim 19, wherein release of topiramate is delayed by 12 hours following release of phentermine.", "23.The method of claim 19, wherein a physiologically effective blood level of topiramate is provided over a 4-hour period.", "24.The method of claim 19, wherein a physiologically effective blood level of topiramate is provided over an 8-hour period.", "25.The method of claim 19, wherein a physiologically effective blood level of topiramate is provided over a 12-hour period.", "26.The method of claim 14, wherein the therapeutically effective amount of topiramate is at most about 250 mg daily.", "27.The method of claim 14.wherein the therapeutically effective amount of phentermine is in the range of about 5 mg to 15 mg daily.", "28.The method of claim 26, wherein the therapeutically effective amount of phentermine is in the range of about 5 mg to about 15 mg daily." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>About 97 million adults in the United States are overweight or obese.", "The medical problems caused by overweight and obesity can be serious and often life-threatening, and include diabetes, shortness of breath, gallbladder disease, hypertension, elevated blood cholesterol levels, cancer, arthritis, other orthopedic problems, reflux esophagitis (heartburn), snoring, sleep apnea, menstrual irregularities, infertility and heart trouble.", "Moreover, obesity and overweight substantially increase the risk of morbidity from hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, gallbladder disease, osteoarthritis and endometrial, breast, prostate, and colon cancers.", "Higher body weights are also associated with increases in all-cause mortality.", "Most or all of these problems are relieved or improved by permanent significant weight loss.", "Longevity is likewise significantly increased by permanent significant weight loss.", "Weight loss treatments vary depending, at least in part, on the degree of weight loss one is attempting to achieve in a subject as well as on the severity of overweight or obesity exhibited by the subject.", "For example, treatments such as low-fat diet and/or regular exercise are often adequate in cases where a subject is only mildly overweight.", "Such treatments can be enhanced by controlled use of over-the-counter appetite suppressants including caffeine, ephedrine and phenylpropanolamine (Acutrim®, Dexatrim®).", "Moreover, prescription medications including amphetamine, diethylpropion (Tenuate®), mazindol (Mazanor®, Sanorex®), phentermine (Fastin®, Ionamin®), phenmetrazine (Preludin®), phendimetrazine (Bontrol®, Plegine®, Adipost®, Dital®, Dyrexan®, Melfiat®, Prelu-2®, Rexigen Forte®), benzphetamine (Didrel®) and fluoxetine (Prozac®) are often used in the treatment of seriously overweight and/or obese subjects or patients.", "However, such treatments, at best, result in only ˜5-10% weight loss (when accompanied with diet and exercise).", "Moreover, most of these treatments ultimately prove inadequate because they are either dangerous, ineffective or quickly lose their anorexient effect.", "At least one class of these prescription medications, the phentermines (Fastin®, Ionamin®), have been used as monotherapy in the treatment of obesity for about 30 years.", "The phentermines are members of a class of drugs known as the sympathomimetics for their ability to mimic stimulation of the central nervous system.", "The phentermines act on the hypothalamus, an appetite control center of the brain.", "Phentermine monotherapy can increase weight loss when used in combination with diet and exercise, as compared to diet and exercise alone.", "However, the drug loses effectiveness after about two weeks and, in fact, is not approved by the FDA for use beyond six weeks.", "Moreover, weight loss may not be permanent, especially after the drug is discontinued.", "Phentermine treatment is also associated with side effects including nervousness, irritability, headache, sweating, dry-mouth, nausea, and constipation.", "In general, available weight loss drugs have limited efficacy and some clinically significant side effects.", "Studies of the weight loss medications dexfenfluramine (Guy-Grand, B. et al.", "(1989) Lancet 2:1142-5), orlistat (Davidson, M. H. et al.", "(1999) JAMA 281:235-42), sibutramine (Bray, G. A. et al.", "(1999) Obes.", "Res.", "7:189-98), and phentermine (Douglas, A. et al.", "(1983) Int.", "J. Obes.", "7:591-5) have shown similar effectiveness.", "Studies for each demonstrated a weight loss of about 5% of body weight for drug compared with placebo.", "Other serious considerations limit the clinical use of these drugs.", "Dexfenfluramine was withdrawn from the market because of suspected heart valvulopathy, orlistat is limited by GI side effects, sibutramine can cause hypertension, and phentermine has limited efficacy.", "Various combination therapies that include phentermine as one of the agents have been investigated and have met with mixed success.", "The phentermines were, up until around 1997, often prescribed along with fenfluramine (Pondimin®) or dexfenfluramine (Redux®), nicknamed “fen”, as a combination therapy known as fen-phen.", "Fenfluramine is a potent releaser of serotonin from serotonergic neurons which acts on a cerebral appetite center.", "When combined with phentermine, fenfluramine had the effect of enhancing and extending the anorexient action of phentermine.", "However in 1997, the Food and Drug Administration (“FDA”) asked manufacturers to withdraw Pondimin® and Redux® due to studies which strongly suggested that the drugs cause damage to the mitral valve of the heart and pulmonary hypertension.", "More recently, it has been suggested that phentermine in combination with anti depressants is a potentially effective therapy for effecting weight loss, U.S. Pat.", "No.", "5,795,895.In particular, the anti-depressants suggested for use in this new combination therapy are members of a class of compounds known as selective serotonin reuptake inhibitors (SSRIs) which include fluoxetine (Prozac®), sertraline (Zoloft®), fluvoxamine maleate (Luvox®) and trazodone hydrochloride (Desyrel®).", "The combination therapy is also suggested to treat coexisting depression and/or obsessive-compulsive disorder.", "Phentermine has also recently been tested in combination with bupropion (Wellbutrin®) for the treatment of obesity.", "Bupropion is an antidepressant that inhibits dopamine reuptake, as compared to serotonin uptake.", "It is also used to treat Attention Deficit Disorder (ADHD), bipolar depression, chronic fatigue syndrome, cocaine addiction, nicotine addiction, and lower back pain.", "While bupropion alone had a modest effect as a weight loss agent (when prescribed to patients following a 1200 calorie per day diet), patients receiving phentermine in combination with bupropion experienced no greater weight loss than those receiving bupropion alone.", "Moreover, bupropion use has been associated with drug-induced seizures causing it to be removed from the market by the FDA for at least five years before its re-introduction in 1989.Accordingly, there exists a need for new, more effective weight loss treatments which are accompanied by fewer adverse or undesirable side effects or less serious side effects.", "In particular, there exists a need for developing medical weight loss treatments which can potentially lower major endpoints such as death and/or myocardial infarction rates by directly treating obesity rather than treating the consequences of obesity (e.g., diabetes, hypertension, hyperlipidemia), as is currently the practice." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present invention features a novel therapy for effecting weight loss which involves treating a subject with a sympathomimetic agent in combination with an anticonvulsant sulfamate derivative such that the subject experiences weight loss.", "In one aspect, the sympathomimetic agent is a compound having anorectic activity (e.g., amphetamine, methamphetamine, benzphetamine, phentermine, chlorphentermine, diethylpropran, phenmetrazine, and phendimetrazine).", "Preferably, the sympathomimetic agent is the drug phentermine (nicknamed “phen”).", "In another aspect, the anticonvulsant sulfamate derivative is the drug topiramate.", "The combination methods of the present invention also are effective against symptoms associated with Syndrome X.", "Accordingly, in another aspect the invention features methods for treating Syndrome X with a combination of a sympathomimetic agent and an anticonvulsant sulfamate derivative (e.g., phentermine and topiramate, respectively) such that at least one symptom associated with Syndrome X is affected.", "Moreover, the combination methods of the present invention have been shown to have beneficial side effects, such as ameliorating sleep apnea and lowering blood pressure, blood glucose, blood lipid, and Hgb A1C levels.", "Accordingly, in another aspect the invention features methods for treating at least one side effect associated with obesity.", "In a preferred embodiment, at least one side effect of obesity is treated with a combination of a sympathomimetic agent in combination with an anticonvulsant sulfamate derivative.", "The invention also features pharmaceutical compositions including therapeutically effective amounts of a sympathomimetic agent in combination with an anticonvulsant sulfamate derivative.", "Kits including the pharmaceutical compositions of the present invention are also featured (e.g., kits including the compositions packaged in a daily dosing regimen).", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "15/614,330, filed Jun.", "5, 2017, which is a continuation of U.S. patent application Ser.", "No.", "15/333,059, filed on Oct. 24, 2016, now abandoned, which is a continuation of U.S. patent application Ser.", "No.", "14/510,639, filed on Oct. 9, 2014, now abandoned, which is a continuation of U.S. patent application Ser.", "No.", "14/317,845, filed on Jun.", "27, 2014, now abandoned, which is a continuation of U.S. patent application Ser.", "No.", "12/683,353, filed Jan. 6, 2010, which is now U.S. Pat.", "No.", "8,802,636, issued on Aug. 12, 2014, which is a continuation of U.S. patent application Ser.", "No.", "11/385,233, filed Mar.", "20, 2006, which is now U.S. Pat.", "No.", "7,674,776, issued on Mar.", "9, 2010, which is a continuation-in-part of U.S. patent application Ser.", "No.", "10/454,368, filed Jun.", "3, 2003, which is now U.S. Pat.", "No.", "7,056,890, issued on Jun.", "6, 2006, which is a continuation-in-part of U.S. patent application Ser.", "No.", "09/593,555, filed Jun.", "14, 2000, now abandoned, which claims priority under 35 U.S.C.", "§ 119(e)(1) to provisional U.S. Patent Application Ser.", "No.", "60/139,022, filed Jun.", "14, 1999, provisional U.S. Patent Application Ser.", "No.", "60/178,563, filed Jan. 26, 2000, and provisional U.S. Patent Application Ser.", "No.", "60/181,265, filed Feb. 9, 2000.Each of the aforementioned patent applications are incorporated herein by reference in their entireties.", "BACKGROUND OF THE INVENTION About 97 million adults in the United States are overweight or obese.", "The medical problems caused by overweight and obesity can be serious and often life-threatening, and include diabetes, shortness of breath, gallbladder disease, hypertension, elevated blood cholesterol levels, cancer, arthritis, other orthopedic problems, reflux esophagitis (heartburn), snoring, sleep apnea, menstrual irregularities, infertility and heart trouble.", "Moreover, obesity and overweight substantially increase the risk of morbidity from hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, gallbladder disease, osteoarthritis and endometrial, breast, prostate, and colon cancers.", "Higher body weights are also associated with increases in all-cause mortality.", "Most or all of these problems are relieved or improved by permanent significant weight loss.", "Longevity is likewise significantly increased by permanent significant weight loss.", "Weight loss treatments vary depending, at least in part, on the degree of weight loss one is attempting to achieve in a subject as well as on the severity of overweight or obesity exhibited by the subject.", "For example, treatments such as low-fat diet and/or regular exercise are often adequate in cases where a subject is only mildly overweight.", "Such treatments can be enhanced by controlled use of over-the-counter appetite suppressants including caffeine, ephedrine and phenylpropanolamine (Acutrim®, Dexatrim®).", "Moreover, prescription medications including amphetamine, diethylpropion (Tenuate®), mazindol (Mazanor®, Sanorex®), phentermine (Fastin®, Ionamin®), phenmetrazine (Preludin®), phendimetrazine (Bontrol®, Plegine®, Adipost®, Dital®, Dyrexan®, Melfiat®, Prelu-2®, Rexigen Forte®), benzphetamine (Didrel®) and fluoxetine (Prozac®) are often used in the treatment of seriously overweight and/or obese subjects or patients.", "However, such treatments, at best, result in only ˜5-10% weight loss (when accompanied with diet and exercise).", "Moreover, most of these treatments ultimately prove inadequate because they are either dangerous, ineffective or quickly lose their anorexient effect.", "At least one class of these prescription medications, the phentermines (Fastin®, Ionamin®), have been used as monotherapy in the treatment of obesity for about 30 years.", "The phentermines are members of a class of drugs known as the sympathomimetics for their ability to mimic stimulation of the central nervous system.", "The phentermines act on the hypothalamus, an appetite control center of the brain.", "Phentermine monotherapy can increase weight loss when used in combination with diet and exercise, as compared to diet and exercise alone.", "However, the drug loses effectiveness after about two weeks and, in fact, is not approved by the FDA for use beyond six weeks.", "Moreover, weight loss may not be permanent, especially after the drug is discontinued.", "Phentermine treatment is also associated with side effects including nervousness, irritability, headache, sweating, dry-mouth, nausea, and constipation.", "In general, available weight loss drugs have limited efficacy and some clinically significant side effects.", "Studies of the weight loss medications dexfenfluramine (Guy-Grand, B. et al.", "(1989) Lancet 2:1142-5), orlistat (Davidson, M. H. et al.", "(1999) JAMA 281:235-42), sibutramine (Bray, G. A. et al.", "(1999) Obes.", "Res.", "7:189-98), and phentermine (Douglas, A. et al.", "(1983) Int.", "J. Obes.", "7:591-5) have shown similar effectiveness.", "Studies for each demonstrated a weight loss of about 5% of body weight for drug compared with placebo.", "Other serious considerations limit the clinical use of these drugs.", "Dexfenfluramine was withdrawn from the market because of suspected heart valvulopathy, orlistat is limited by GI side effects, sibutramine can cause hypertension, and phentermine has limited efficacy.", "Various combination therapies that include phentermine as one of the agents have been investigated and have met with mixed success.", "The phentermines were, up until around 1997, often prescribed along with fenfluramine (Pondimin®) or dexfenfluramine (Redux®), nicknamed “fen”, as a combination therapy known as fen-phen.", "Fenfluramine is a potent releaser of serotonin from serotonergic neurons which acts on a cerebral appetite center.", "When combined with phentermine, fenfluramine had the effect of enhancing and extending the anorexient action of phentermine.", "However in 1997, the Food and Drug Administration (“FDA”) asked manufacturers to withdraw Pondimin® and Redux® due to studies which strongly suggested that the drugs cause damage to the mitral valve of the heart and pulmonary hypertension.", "More recently, it has been suggested that phentermine in combination with anti depressants is a potentially effective therapy for effecting weight loss, U.S. Pat.", "No.", "5,795,895.In particular, the anti-depressants suggested for use in this new combination therapy are members of a class of compounds known as selective serotonin reuptake inhibitors (SSRIs) which include fluoxetine (Prozac®), sertraline (Zoloft®), fluvoxamine maleate (Luvox®) and trazodone hydrochloride (Desyrel®).", "The combination therapy is also suggested to treat coexisting depression and/or obsessive-compulsive disorder.", "Phentermine has also recently been tested in combination with bupropion (Wellbutrin®) for the treatment of obesity.", "Bupropion is an antidepressant that inhibits dopamine reuptake, as compared to serotonin uptake.", "It is also used to treat Attention Deficit Disorder (ADHD), bipolar depression, chronic fatigue syndrome, cocaine addiction, nicotine addiction, and lower back pain.", "While bupropion alone had a modest effect as a weight loss agent (when prescribed to patients following a 1200 calorie per day diet), patients receiving phentermine in combination with bupropion experienced no greater weight loss than those receiving bupropion alone.", "Moreover, bupropion use has been associated with drug-induced seizures causing it to be removed from the market by the FDA for at least five years before its re-introduction in 1989.Accordingly, there exists a need for new, more effective weight loss treatments which are accompanied by fewer adverse or undesirable side effects or less serious side effects.", "In particular, there exists a need for developing medical weight loss treatments which can potentially lower major endpoints such as death and/or myocardial infarction rates by directly treating obesity rather than treating the consequences of obesity (e.g., diabetes, hypertension, hyperlipidemia), as is currently the practice.", "SUMMARY OF THE INVENTION The present invention features a novel therapy for effecting weight loss which involves treating a subject with a sympathomimetic agent in combination with an anticonvulsant sulfamate derivative such that the subject experiences weight loss.", "In one aspect, the sympathomimetic agent is a compound having anorectic activity (e.g., amphetamine, methamphetamine, benzphetamine, phentermine, chlorphentermine, diethylpropran, phenmetrazine, and phendimetrazine).", "Preferably, the sympathomimetic agent is the drug phentermine (nicknamed “phen”).", "In another aspect, the anticonvulsant sulfamate derivative is the drug topiramate.", "The combination methods of the present invention also are effective against symptoms associated with Syndrome X.", "Accordingly, in another aspect the invention features methods for treating Syndrome X with a combination of a sympathomimetic agent and an anticonvulsant sulfamate derivative (e.g., phentermine and topiramate, respectively) such that at least one symptom associated with Syndrome X is affected.", "Moreover, the combination methods of the present invention have been shown to have beneficial side effects, such as ameliorating sleep apnea and lowering blood pressure, blood glucose, blood lipid, and Hgb A1C levels.", "Accordingly, in another aspect the invention features methods for treating at least one side effect associated with obesity.", "In a preferred embodiment, at least one side effect of obesity is treated with a combination of a sympathomimetic agent in combination with an anticonvulsant sulfamate derivative.", "The invention also features pharmaceutical compositions including therapeutically effective amounts of a sympathomimetic agent in combination with an anticonvulsant sulfamate derivative.", "Kits including the pharmaceutical compositions of the present invention are also featured (e.g., kits including the compositions packaged in a daily dosing regimen).", "DETAILED DESCRIPTION OF THE INVENTION The present invention is directed to a novel combination therapy for effecting weight loss in a subject.", "In particular, the present invention provides methods which involve treating the subject with a therapeutically effective amount of a combination of a sympathomimetic agent (e.g., phentermine or a phentermine-like compound) and an anticonvulsant sulfamate derivative (e.g., topiramate).", "The methods are particularly useful for the treatment of overweight and/or obesity, as well as in the treatment of Syndrome X.", "The phrase “therapeutically effective amount” as used herein refers to the amount of an agent, compound, drug, composition, or combination of the invention which is effective for producing some desired therapeutic effect upon administration to a subject or patient (e.g., a human subject or patient).", "The phrase “administering to a subject” or “administering to a patient” refers to the process of introducing an agent, compound, drug, composition or combination of the invention into the subject or patient's body via an art-recognized means of introduction (e.g., orally, transdermally, via injection, etc.).", "The term “sympathomimetic agent” is a term of art and refers to agents or compounds which “mimic” or alter stimulation of the sympathetic nervous system (e.g., stimulates the peripheral nervous system) of an organism (e.g., mimic the stimulation naturally effected by physical activity, psychological stress, generalized allergic reaction and other situations in which the organism is provoked).", "Preferred sympathomimetic agents for use in the present invention as well as there general clinical uses or effects are set forth in Table I.", "TABLE I Sympathomimetic Agents and Clinical Uses Thereof Main Clinical Uses Ring α Receptor β Receptor Agent name substituent(s) Rα Rβ Rγ A N P V B C CNS, 0 Phenylethylamine H H H Epinephrine 3-OH, 4-OH OH H CH3 A, P, V B, C Norepinephrine 3-OH, 4-OH OH H H P Epinine 3-OH, 4-OH H H CH3 Dopamine 3-OH, 4-OH H H H P Dobutamine 3-OH, 4-OH H H 1* C Nordefrin 3-OH, 4-OH OH CH3 H V Ethylnorepinephrine 3-OH, 4-OH OH CH2CH3 H B Isoproterenol 3-OH, 4-OH OH H CH(CH3)2 B, C Protokylol 3-OH, 4-OH OH H 2* B Isoetharine 3-OH, 4-OH OH CH2CH3 CH(CH3)2 B Metaproterenol 3-OH, 5-OH OH H CH(CH3)2 B Terbutaline 3-OH, 5-OH OH H C(CH3)3 B Metaraminol 3-OH OH CH3 H P Phenylephrine 3-OH OH H CH3 N, P Tyramine 4-OH H H H Hydroxyamphetamine 4-OH H CH3 H N, P C Methoxyphenamine 2-OCH3 H CH3 CH3 B Methoxamine 2-OCH3, 5-OCH3 OH CH3 H P Albuterol 3-CH2OH, 4-OH OH H C(CH3)3 B Amphetamine H CH3 H CNS, 0 Methamphetamine H CH3 CH3 P CNS, 0 Benzphetamine H CH3 —NHRγ is 0 replaced with 3* Ephedrine OH CH3 CH3 N, P B, C Phenylpropanolamine OH CH3 H N Mephentermine H —CHRβ— is CH3 N, P replaced with 4* Phentermine H —CHRβ— is H 0 replaced with 4* Chlorphentermine 4-Cl H —CHRβ— is H 0 replaced with 4* Fenfluramine 3-CF3 H CH3 C2H5 0 Propylhexedrine 5*: phenyl ring H CH3 CH3 N is replaced with cyclohexyl Diethylpropion 6*: The substituent at the 1 - 0 position is replaced with 6, below.", "Phenmetrazine 7*: The substituent at the 1 - 0 position is replaced with 7, below.", "Phendimetrazine 8*: The substituent at the 1 - 0 position is replaced with 8, below.", "*1: *2: *3: *4: *5: *6: *7: *8: α Activity A = Allergic reactions (includes β action) N = Nasal decongestion P = Pressor (may include β action) V = Other local vasoconstriction (e.g.", "in local anesthesia) β Activity B = Bronchodilator C = Cardiac CNS = Central nervous system 0 = Anorectic *Numbers bearing an asterisk refer to the substituents numbered in the bottom rows of the table; substituent 5 replaces the phenyl rings, and 6, 7 and 8 are attached directly to the phenyl ring, replacing the ethylamine side chain.", "†The α and β in the prototype formula refer to positions of the C atoms in the ethylamine side chain.", "In preferred embodiments, the sympathomimetic agent has anorexient properties (e.g., suppresses appetite) or is anorectic without significant toxicity to a subject or patient (e.g., a human) at therapeutically effective doses.", "In a more preferred embodiment, the sympathomimetic agent has anorexient properties (e.g., suppresses appetite) or is anorectic without loss of efficacy or without adverse or undesirable side effects to a subject or patient (e.g., a human subject or patient) at therapeutically effective doses when prescribed in combination with topiramate.", "In yet another embodiment, the sympathomimetic agent is phentermine or a phentermine-like compound.", "As defined herein, a “phentermine-like compound” is a compound structurally related to phentermine (e.g., an analog or derivative) which maintains an anorectic activity similar to that of phentermine.", "A preferred phentermine-like compound is chlorphentermine.", "In yet another embodiment, the sympathomimetic agent is amphetamine or an amphetamine-like compound.", "As used herein, an “amphetamine-like compound” is a compound structurally related to amphetamine (e.g., an analog or derivative) which maintains an anorectic effect of amphetamine.", "In yet another embodiment, the sympathomimetic agent is phenmetrazine or a phenmetrazine-like compound.", "As defined herein, a “phenmetrazine-Iike compound” is a compound structurally related to phenmetrazine (e.g., an analog or derivative) which maintains an anorectic effect of phenmetrazine.", "A preferred phenmetrazine-like compound is phendimetrazine.", "Analogs and/or derivatives of the compounds of the present invention can be tested for their ability to suppress appetite (e.g., suppress food intake) in a subject (e.g., a mammalian subject).", "In an exemplary preferred embodiment, the sympathomimetic agent is selected from the group consisting of amphetamine, methamphetamine, benzphetamine, phenylpropanolamine, phentermine, chlorphentermine, diethylpropion, phenmetrazine, and phendimetrazine (as set forth in Table I.", "In a particularly preferred embodiment, the sympathomimetic agent is phentermine.", "It is also within the scope of the present invention to utilize other sympathomimetic agents including pseudo ephedrine (a stereoisomer of ephedrine, SUDAFED®), methylphenidate (RITALIN®), tuaminoheptane, and other CNS stimulants including, for example, caffeine.", "The terms “anticonvulsant sulfamate derivative” and “anticonvulsant sulfamate derivatives” are terms of art and refer to a class of sulfamate-derived compounds that possess anticonvulsant activity and have an art-recognized use in the treatment of epilepsy.", "In particular, the anticonvulsant sulfamate derivatives are monosaccharide derivatives with sulfamate functionality.", "The anticonvulsant sulfamate derivatives for use in the present invention have one or more of the following modes of activity: modulation of voltage-dependent sodium conductance; potentiation of gamma-aminobutyric acid-evoked currents; inhibition of the kainate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) subtype of the glutamate receptor; and/or inhibition of carbonic anhydrase (e.g, a mechanism by which the anticonvulsant derivative of the present invention may decrease the sensation of taste).", "The anticonvulsant sulfamate derivatives for use in the present invention are described further in U.S. Pat.", "Nos.", "4,513,006, 5,384,327, 5,498,629, 5,753,693 and 5,753,694, as are methods of synthesizing such anticonvulsant sulfamate derivatives.", "The aforementioned patents are incorporated by reference herein in their entireties.", "In preferred embodiments, the anticonvulsant sulfamate derivative is a compound having the following formula (I): wherein: X is CH2 or O; R1 is H or alkyl; and R2, R3, R4 and R5 are independently H or lower alkyl, with the proviso that when X is O, then R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of the following formula (II): in which R6 and R7 are the same or different and are H or lower alkyl, or are joined to form a cyclopentyl or cyclohexyl ring.", "R1 in particular is hydrogen or alkyl of about 1 to 4 carbons, such as methyl, ethyl, or isopropyl.", "Alkyl includes both straight and branched chain alkyl.", "Alkyl groups R2, R3, R4, R5, R6 and R7 are about 1 to 3 carbons and include methyl, ethyl, isopropyl and n-propyl.", "A particular group of compounds of the formula (I) are those wherein X is oxygen and both R2 and R3, and R4 and R5 together are methylenedioxy groups of the formula (II), wherein R6 and R7 are both hydrogen, both alkyl, or combine to form a spiro cyclopentyl or cyclohexyl ring, in particular, where R6 and R7 are both alkyl such as methyl.", "A second group of compounds are those wherein X is CH2 and R4 and R5 are joined to form a benzene ring.", "A third group of compounds of the formula (I) are those wherein both R2 and R3 are hydrogen.", "In preferred embodiments, the anticonvulsant sulfamate derivatives have anorexient properties (e.g., suppress appetite) without significant toxicity to a subject or patient (e.g., a human) at therapeutically effective doses.", "In a more preferred embodiment, the anticonvulsant sulfamate derivatives have anorexient properties (e.g., suppress appetite) without significant adverse or undesirable side effects to a subject or patient (e.g., a human) at therapeutically effective doses when prescribed in combination with phentermine.", "In a particularly preferred embodiment the anticonvulsant sulfamate derivative is topiramate (Topamax®).", "Topiramate, also referred to in the art as 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate, has been demonstrated in clinical trials of human epilepsy to be effective as an adjunctive therapy or as monotherapy in treating simple and complex partial seizures and secondarily generalized seizures (E. Faught et al.", "(1995) Epilepsia 36(suppl 4):33; S. Sachdeo et al (1995) Epilepsia 36(suppl 4):33) and is currently marketed for the treatment of simple and complex partial seizure epilepsy with or without secondary generalized seizures.", "Dosages, Administration and Pharmaceutical Compositions: The choice of appropriate dosages for the drugs used in combination therapy according to the present invention can be determined and optimized by the skilled artisan, e.g., by observation of the patient, including the patient's overall health, the response to the combination therapy, and the like.", "Optimization, for example, may be necessary if it is determined that a patient is not exhibiting the desired therapeutic effect or conversely, if the patient is experiencing undesirable or adverse side effects that are too many in number or are of a troublesome severity.", "Preferably, a sympathomimetic drug (e.g., a drug set forth in Table I) is prescribed at a dosage routinely used by the skilled artisan (e.g., physician) to promote the desired therapeutic effect of the drug, when the drug is used as a monotherapy.", "Preferably, an anticonvulsant sulfamate derivative (e.g., a compound having formula I) is prescribed at a lower dosage than routinely used by the skilled artisan (e.g., physician) to promote the desired therapeutic effect of the drug, when the drug is used as a monotherapy (e.g., in the treatment of epilepsy).", "In a preferred embodiment, a sympathomimetic drug or anticonvulsant sulfamate derivative is prescribed at a dose of between 5-1000, preferably between 10-1500, more preferably between 20-1000 and most preferably between 25-50 mg daily.", "It is especially advantageous to formulate compositions of the invention in unit dosage form for ease of administration and uniformity of dosage.", "The term “unit dosage forms” as used herein refers to physically discrete units suited as unitary dosages for the individuals to be treated.", "That is, the compositions are formulated into discrete dosage units each containing a predetermined, “unit dosage” of an active compound calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier.", "The specifications of the novel dosage unit forms of the invention are dependent on the unique characteristics of the composition containing the anticonvulsant or sympathomimetic agent and the particular therapeutic effect to be achieved.", "Dosages can further be determined by reference to the usual dose and manner of administration of the ingredients.", "It is also within the scope of the present invention to formulate a single physically discrete dosage form having each of the active ingredients of the combination treatment (e.g., a single dosage form having an anticonvulsant agent and a sympathomimetic agent).", "The method of administration of compositions or combinations of the invention will depend, in particular, on the type of sympathomimetic agent used and the chosen anticonvulsant sulfamate derivative.", "The sympathomimetic agent and the anticonvulsant sulfamate derivative may be administered together in the same composition or simultaneously or sequentially in two separate compositions.", "Also, one or more sympathomimetic agents or one or more anticonvulsant sulfamate derivatives may be administered to a subject or patient either in the form of a therapeutic composition or in combination, e.g., in the form of one or more separate compositions administered simultaneously or sequentially.", "The schedule of administration will be dependent on the type of sympathomimetic agent(s) and anticonvulsant sulfamate derivative(s) chosen.", "For example, a sympathomimetic agent can have a stimulant effect and the degree of such stimulant effect may vary depending on the sympathomimetic agent chosen.", "Accordingly, a sympathomimetic agent having a significant stimulant effect might be administered earlier in the day than administration of a sympathomimetic agent having a lesser stimulant effect.", "Likewise, an anticonvulsant sulfamate derivative can have a sedative effect and the degree of such sedative effect may vary depending on the anticonvulsant sulfamate derivative chosen.", "Accordingly, an anticonvulsant sulfamate derivative having a significant sedative effect might be administered later in the day than administration of an anticonvulsant sulfamate derivative having a lesser sedative effect.", "Moreover, sympathomimetic agents and/or anticonvulsant agents having lesser stimulant or sedative effects, respectively, may be administered simultaneously.", "Sympathomimetic agents and/or anticonvulsant sulfamate derivatives can also be administered along with a pharmaceutically acceptable carrier.", "As used herein “pharmaceutically acceptable carrier” includes any solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents, and the like.", "The use of such media and agents for pharmaceutically active substances is well known in the art.", "Except insofar as any conventional media or agent is incompatible with the active compound, use thereof in compositions of the invention is contemplated.", "A sympathomimetic agent alone, or in combination with an anticonvulsant sulfamate derivative in the form of a composition, is preferably administered orally.", "When the composition(s) are orally administered, an inert diluent or an assimilable edible carrier may be included.", "The composition and other ingredients may also be enclosed in a hard or soft shell gelatin capsule, compressed into tablets, or incorporated directly into the individual's diet.", "For oral therapeutic administration, the composition may be incorporated with excipients and used in the form of ingestible tablets, buccal tablets, troches, capsules, elixirs, suspensions, syrups, wafers, and the like.", "The percentage of the compositions and preparations may, of course, be varied.", "The amount of active compound in such therapeutically useful compositions is such that a suitable dosage will be obtained.", "In a particularly preferred embodiment, the present invention includes pharmaceutical composition comprising a therapeutically effective amount of a sympathomimetic agent and an anticonvulsant sulfamate derivative.", "In one embodiment, the present invention includes a therapeutically-effective amount of a sympathomimetic agent and an anticonvulsant sulfamate derivative packaged in a daily dosing regimen (e.g., packaged on cards, packaged with dosing cards, packaged on blisters or blow-molded plastics, etc.).", "Such packaging promotes products and increases patient compliance with drug regimens.", "Such packaging can also reduce patient confusion.", "The present invention also features such kits further containing instructions for use.", "The tablets, troches, pills, capsules and the like may also contain a binder, an excipient, a lubricant, or a sweetening agent.", "Various other materials may be present as coatings or to otherwise modify the physical form of the dosage unit.", "For instance, tablets, pills, or capsules may be coated with shellac, sugar or both.", "Of course, any material used in preparing any dosage unit form should be pharmaceutically pure and substantially non-toxic in the amounts employed.", "A sympathomimetic agent, alone or in combination with an anticonvulsant sulfamate derivative, can also be administered in a convenient manner such as by injection (subcutaneous, intravenous, etc.", "), inhalation, transdermal application, or rectal administration.", "Depending on the route of administration, the composition containing the sympathomimetic agent and/or anticonvulsant sulfamate derivative may be coated with a material to protect the compound from the action of acids and other natural conditions which may inactivate the compounds or compositions.", "To administer the compositions, for example, transdermally or by injection, it may be necessary to coat the composition with, or co-administer the composition with, a material to prevent its inactivation.", "For example, the composition may be administered to an individual in an appropriate diluent or in an appropriate carrier such as liposomes.", "Pharmaceutically acceptable diluents include saline and aqueous buffer solutions.", "Liposomes include water-in-oil-in-water CGF emulsions as well as conventional liposomes (Strejan et al.", "(1984) J. Neuroimmunol.", "7:27).", "To administer the compositions containing the sympathomimetic agents and/or anticonvulsant sulfamate derivatives parenterally or intraperitoneally, dispersions can be prepared in glycerol, liquid polyethylene glycols, and mixtures thereof and in oils.", "Under ordinary conditions of storage and use, these preparations may contain a preservative to prevent the growth of microorganisms.", "Compositions suitable for injectable use include sterile aqueous solutions (where water soluble) or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersion.", "In all cases, the composition must be sterile and must be fluid to the extent that easy syringability exists.", "It must be stable under the conditions of manufacture and storage and must be preserved against the contaminating action of microorganisms such as bacteria and fungi.", "The carrier can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (for example, glycerol, propylene glycol, and liquid polyetheylene gloycol, and the like), suitable mixtures thereof, and vegetable oils.", "The proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersion and by the use of surfactants.", "Prevention of the action of microorganisms can be achieved by various antibacterial and antifungal agents.", "In many cases, it will be preferable to include isotonic agents, for example, sugars, polyalcohols such as mannitol and sorbitol, or sodium chloride in the composition.", "Prolonged absorption of the injectable compositions can be brought about by including in the composition an agent which delays absorption, for example, aluminum monostearate and gelatin.", "A preferred aspect of the present invention features prescribing phentermine in combination with topiramate to effect weight loss and/or to treat Syndrome X and/or a subset of symptoms thereof.", "A preferred dose for phentermine is between about 5-60 mg daily, including but not limited to doses of 8, 10, 15, 20, 25, 30, 35, 40, 45, 50 and 55 mg daily.", "A particularly preferred dose for phentermine is about 15 mg daily.", "In an exemplary embodiment, the phentermine is of an immediate release form.", "Preferably, the phentermine is taken by the patent in the morning and more preferably, is taken before breakfast.", "The phentermine is best taken in the morning because the drug is a stimulant as well as an appetite suppressant.", "When phentermine is prescribed (e.g., as part of the combination therapy described herein), physicians should be aware and may want to advise patients that the drug can be mildly habit forming.", "Phentermine can also cause increased nervousness, increased energy, irritability and, rarely, insomnia.", "Stopping phentermine may also cause tiredness lasting for up to 1-2 weeks.", "Phentermine can also raise blood pressure (e.g., during the early phases of treatment).", "A preferred dose for topiramate is between about 50-1500 mg daily.", "As discussed previously, prescription of topiramate at dosages of ≥400 mg daily results is promotion of undesirable side effects (e.g., sedation, mental clouding).", "Accordingly, in a preferred embodiment, topiramate is prescribed at a dose of about 50-400 mg daily.", "In another preferred embodiment, the dosage of topiramate is increased gradually at the outset of the therapy in order to reduce the chance of undesirable side effects associated with higher doses of the drug.", "In an exemplary embodiment, the topiramate is administered at a dose of 25 mg daily for about the first 5-7 days (e.g., 6 days) of treatment, at a dose of about 50 mg daily for the next 5-7 days (e.g., 6 days), at a dose of 100 mg daily for about the next 6-8 days (e.g., 7 days) and about 150 mg daily for the next 20-26 days.", "From this point forward, the topiramate can be administered at a dose of 150-250 mg daily, including but not limited to doses of 175, 200, and 225 mg daily.", "A particularly preferred dose for continued therapy is about 200 mg of topiramate daily.", "In another exemplary embodiment, the topiramate is of an immediate release form.", "In yet another exemplary embodiment, the topiramate is of a sustained release form.", "In a preferred embodiment, topiramate is taken later in the day than the phentermine.", "Preferably, the patient takes the topiramate just before supper or later in the evening.", "Topiramate is best given later in the day because the drug can be sedating.", "In other embodiments, the topiramate is given BID (e.g., twice daily), TID (three times daily) or QID (four time daily).", "When prescribing topiramate, physicians should be aware and may want to advise patients that the drug can cause tiredness, fatigue, dizziness, difficulty with speech or finding words, difficulty concentrating, difficulty with balance, and/or numbness or tingling in the hands or feet.", "Less common side effects are nausea, coordination problems, abdominal pain, slowed thinking nervousness, depression, breast pain, painful periods, double or blurred vision, palpitations, low white blood count and kidney stones.", "A physician should also advise patients that the drug may not be taken if the patient is also taking Diamox (acetazolamide).", "No female patient should become pregnant while taking this drug as it may cause birth defects.", "If a female patient misses a period she should immediately discontinue taking the medication and inform the physician.", "Female patients should not be treated according to the methods of the present invention if breast feeding a child.", "Patients should not drink alcohol or take sedating medications while taking topiramate since excess sedation can occur.", "Patients should also refrain from performing dangerous tasks (e.g.", "operating heavy machinery or driving) until they are comfortable with the side effects of the full dose (e.g., 200-400 mg daily).", "Patients should be advised not to increase the dosage beyond what is prescribed.", "Topiramate is not habit forming.", "Yet another embodiment of the present invention features pharmaceutical compositions (e.g., for oral administration) comprising phentermine and topiramate in a single pharmaceutical formulation.", "Such compositions may be preferred, for example, to increase patient compliance (e.g., by reducing the number of administrations necessary to achieve the desired pharmacologic effect).", "In a preferred embodiment, the pharmaceutical composition includes phentermine in an immediate release form and further includes topiramate in a controlled release formulation.", "As defined herein, an “immediate release formulation” is one which has been formulated to allow, for example, the phentermine, to act as quickly as possible.", "Preferred immediate release formulations include, but are not limited to, readily dissolvable formulations.", "As defined herein, a “controlled release formulation” includes a pharmaceutical formulation that has been adapted such that drug release rates and drug release profiles can be matched to physiological and chronotherapeutic requirements or, alternatively, has been formulated to effect release of a drug at a programmed rate.", "Preferred controlled release formulations include, but are not limited to, granules, delayed release granules, hydrogels (e.g., of synthetic or natural origin), other gelling agents (e.g., gel-forming dietary fibers), matrix-based formulations (e.g., formulations comprising a polymeric material having at least one active ingredient dispersed therethrough), granules within a matrix, polymeric mixtures, granular masses, and the like.", "In one embodiment, a controlled release formulation is a delayed release form.", "As defined herein, a “delayed release form” is formulated in such a way as to delay, for example, topiramate's action for an extended period of time.", "A delayed release form can be formulated in such a way as to delay the release of an effective dose of topiramate for 4, 8, 12, 16 or 24 hours following the release of phentermine.", "In yet another preferred embodiment, a controlled release formulation is a sustained release form.", "As defined herein, a “sustained release form” is formulated in such a way as to sustain, for example, the topiramate's action over an extended period of time.", "A sustained release form can be formulated in such a way as to provide an effective dose of topiramate (e.g., provide a physiologically effective blood level) over a 4, 8, 12,16 or 24 hour period.", "Preferred compositions include a tablet core consisting essentially of topiramate, said core being in association with a layer of phentermine.", "Preferably, the core has a delayed or sustained dissolution rate.", "In an exemplary embodiment, a tablet can comprise a first layer containing, for example, phentermine (e.g., in an immediate release formulation) and a core containing, for example, topiramate in a delayed release or sustained release formulation.", "Other exemplary embodiments can include, for example, a barrier between the first layer and core, said layer serving the purpose of limiting drug release from the surface of the core.", "Preferred barriers prevent dissolution of the core when the pharmaceutical formulation is first exposed to gastric fluid.", "For example, a barrier can comprise a disintegrant, a dissolution-retarding coating (e.g., a polymeric material, for example, an enteric polymer), or a hydrophobic coating or film, and can be selectively soluble in either the stomach or intestinal fluids.", "Such barriers permit the topiramate to leach out slowly and can cover substantially the whole surface of the core.", "The above-described pharmaceutical compositions are designed to release the two effective agents of the combination therapy of the present invention sequentially, i.e., releasing topiramate after releasing phentermine, both agents being contained in the same pharmaceutical composition.", "Preferred amounts of phentermine and topiramate are as described above with particularly preferred compositions comprising from about 5 mg to about 60 mg phentermine and from about 50 mg to 1500 mg topiramate.", "Particularly preferred compositions include at least 15 mg phentermine and at least about 50 mg, 100 mg or 200 mg topiramate.", "Pharmaceutical compositions so formulated may contain additional additives, suspending agents, diluents, binders or adjuvants, disintegrants, lubricants, glidants, stabilizers, coloring agents, flavors, etc.", "These are conventional materials which may be incorporated in conventional amounts.", "In one embodiment, a method of the present invention is carried out, practiced or performed such that weight loss in the subject or patient occurs.", "Accordingly, the methods of the present invention are particularly useful for the treatment of overweight or obese patients.", "As defined herein, “overweight” subjects or patients are between about 1 and 20 percent overweight (e.g., weighs 1-20% in excess of their ideal body weight).", "Also as defined herein, an “obese” subject or patient is greater than 20 percent overweight (e.g., weighs >20% in excess of his or her ideal body weight).", "Alternatively, the methods of the present invention are useful in the treatment of subjects or patients in need of losing weight, but who are not necessarily overweight or obese.", "For example, it may be desirable to achieve weight loss in subjects or patients having arthritis or prostheses such that the individual experiences less adverse effects resulting from bearing weight.", "The combination therapies of the present invention will generally be administered until the patient has experienced the desired weight loss, and preferably has achieved an ideal body weight.", "Alternatively, the combination therapies of the present invention can be administered until the patient has achieved a weight loss of 5-10%, 10-15%, 15-20% or 20-25% of their initial body mass (e.g., the patient's starting weight).", "The present inventor has also recognized that the combination therapy of the present invention ameliorates symptoms associated with Syndrome X.", "Syndrome X consists of a complex of medical problems that are largely associated with obesity, including, hypertension, diabetes or glucose intolerance and insulin resistance, hyperlipidemia, and often tiredness and sleepiness associated with sleep apnea.", "Patients are often treated with combinations of antihypertensives, lipid lowering agents, insulin or oral diabetic drugs, and various mechanical and surgical treatments of sleep apnea.", "However, such treatments are often costly and do not treat the underlying problem of obesity.", "Moreover, some of the treatments for diabetes, including insulin and oral diabetic agents, actually aggravate Syndrome X by increasing insulin levels, increasing appetite, and increasing weight.", "This can lead to higher blood pressure and even higher cholesterol.", "Accordingly, one aspect of the present invention features a method of treating Syndrome X using the combination therapies described herein.", "In one embodiment, the invention features a method of treating Syndrome X in a subject or patient which includes treating the subject with a therapeutically effective amount of a combination of an anticonvulsant sulfamate derivative (e.g., topiramate) and a sympathomimetic agent (e.g., phentermine or a phentermine-like compound), such that at least one symptom associated with Syndrome X is affected.", "As defined herein, “affecting a symptom” (e.g., affecting a symptom associated with Syndrome X) refers to lessening, decreasing the severity of the symptom or reversing, ameliorating, or improving the symptom (e.g., decreasing hypertension, ameliorating diabetes, reversing glucose intolerance or insulin resistance, lessening hyperlipidemia, or decreasing tiredness and sleepiness associated with sleep apnea).", "Treatment of Syndrome X according to the methods of the present invention includes affecting at least one, preferably two, more preferably three, more preferably four, five or six symptoms associated with Syndrome X.", "In a particularly preferred embodiment, all symptoms associated with Syndrome X are affected (e.g., lessened, reversed, ameliorated, etc.).", "The present inventor has also recognized that the combination therapy of the present invention ameliorates some side effects associated with obesity, as described herein.", "Accordingly, one aspect of the present invention features a method of treating at least one side effect associated with obesity using the combination therapies described herein.", "In one embodiment, the invention features a method of treating at least one obesity-related side effect in a subject or patient which includes treating the subject with a therapeutically effective amount of a combination of an anticonvulsant sulfamate derivative (e.g., topiramate) and a sympathomimetic agent (e.g., phentermine or a phentermine-like compound), such that at least one obesity-related side effect is effected.", "As defined herein, a “side effect associated with obesity” includes a symptom or disorder in a subject (e.g., a patient) which is secondary and/or results from (e.g., directly and/or indirectly results from) a medical condition for which the subject is obese and/or being treated.", "In a preferred embodiment, the subject is obese and/or is being treated for obesity.", "In another embodiment, the subject has at least one or more (e.g., two, three, four, five or more) side effect(s) selected from the group consisting of sleep apnea, high blood pressure and high blood sugar, high blood lipid, high Hgb A1C or other art-recognized side effects associated with obesity.", "Whether in the treatment of Syndrome X or in the practicing of the methods of the present invention to effect weight loss (e.g., in the treatment of overweight and/or obesity) or in treatment of side effects associated with obesity, it will be apparent to the skilled artisan (e.g., physician) that monitoring of the patient is needed to determine the effectiveness of the treatments and to potentially modify the treatments (e.g., modify the dosing, time of drug administration, sequence of drug administration, as defined herein).", "Accordingly, in certain embodiments, the patient is monitored about every 2-6, preferably every 3-5 and more preferably every 4 weeks.", "Monitoring the effective of treatment to achieve weight loss includes, but is not limited to monitoring the subject or patient's body weight (e.g., comparing the patient's initial body weight to that at a follow-up visit, for example, four weeks after the initiation of treatment).", "Additional features of the subject or patient's health can also be monitored (i.e., monitoring the patient's overall health and/or monitoring the effectiveness of treatment of an undesired side effect of obesity) including, but not limited to the patient's blood pressure, blood sugar, serum lipid levels, etc.", "Likewise, monitoring a subject or patient for treatment of Syndrome X can include monitoring of at least one, preferably more than one symptom associated with Syndrome X.", "This invention is further illustrated by the following examples which should not be construed as limiting.", "The contents of all references, patents and published patent applications cited throughout this application are hereby incorporated by reference.", "Example 1 Patients as part of the following trial were treated according to the following dosage regimen.", "Patients took phentermine at a dose of 15 mg daily throughout the weight loss program, before breakfast.", "For the first 6 days, patients took one 25 mg tablet of topiramate before supper.", "For the next 6 days, patients took two 25 mg tablets of topiramate before supper.", "For the next 7 days (days 13-19), patients took 100 mg before supper daily using 4-25 mg tablets of topiramate daily.", "For days 20-26, patients took 150 mg of topiramate daily consisting of one-half of a 200 mg tablet and two 25-mg mg tablets of topiramate.", "From that point on, unless instructed otherwise by the physician, patients continued to take one 200 mg topiramate tablet daily before supper and continued the 15 mg phentermine daily in the morning.", "Patients were advised to drink at least eight (8) full glasses of water daily to reduce the risk of kidney stones which may result from taking topiramate.", "Patients were advised that while the effect of phentermine is fairly rapid, the effect of topiramate is slower in onset.", "The weight reduction effect of topiramate will continue for as long as 18 months on the medication.", "That is, the patient can expect to continue gradual weight loss for up to 18 months on the medication.", "Of course, weight loss is maximal if the patient follows diet and/or exercise programs.", "The weight loss should exceed 15% of the patients starting weight.", "Thus, if the patient weighs about 200 pounds as of the start date, he/she might expect to lose at least 30 pounds in a period of 12-18 months.", "The following patient data has been collected.", "TABLE II Start Follow-Up Follow- Patient's Start Weight Blood Follow- Weight % Weight Up Blood Initials Age Sex (lbs) Pressure Up Date (lbs) Loss Pressure M. O.1 48 F 182 115/70 5 weeks 177 2.7% 120/80 9 weeks 176 3.3% 110/70 T. M. 37 F 190 122/84 2 weeks, 178 6.3% 110/80 5 days 6 weeks, 168 11.6% 125/80 2 days D. M. (A) 28 M 286 138/90 4 weeks 279 2.4% 128/86 P. L. 55 F 144 132/84 4 weeks 141 2.1% 138/85 9 weeks 137 4.9% 122/82 E. K. 52 F 181 130/100 5 weeks 175 3.3% 140/88 I. F. 41 F 196 95/60 6 weeks, 5 days D. M. (B)2 56 M 295 150/80 4 weeks, 297 (+0.7%) 148/82 2 days 8 weeks, 287 2.7% 140/70 2 days 1Patient M. O. was being treated with Meridia ® at the onset of the study, which continued through the first 5 weeks of the study.", "At the 5-week follow up, M. O. was switched to the phentermine/topiramate regime described above.", "2Patient D. M. (B) was being treated with phentermine alone at the onset of the study and was taking the full dose of topiramate by the fourth week of the study.", "As is apparent from the above-described data, patients not previously treated with an anorexient at the outset of the study experienced an average of about 3.5% weight loss after only 2-6 weeks (e.g., patient T.M.", "lost 6.3% body weight, patient D.M.", "(A) lost 2.4% body weight, patient P.L.", "lost 2.1% body weight and patient E.K.", "lost 3.3% body weight).", "After only 6-9 weeks of treatment, patients (not previously treated with an anorexient at the outset of the study experienced an average of about 8.3% weight loss (e.g., patient T.M.", "lost 11.6% body weight and patient P.L.", "lost 4.9% body weight).", "The patient previously on Meridia® (patient M.O.)", "lost 3.3% body weight after being enrolled in the program for 9 weeks.", "Moreover, the patient previously on phentermine (patient D.M.", "(B)) lost a total of 2.7% body weight after being enrolled in the program for about 8 weeks.", "This particular patient reported that this is the most significant weight loss he has achieved to date, the patient having previously tried other conventional therapies.", "In addition to the weight loss reported above, almost all patients enrolled in the study experienced decreased blood pressure.", "Moreover, patients involved in the study who had previously taken Redux, phen-fen, Meridia and/or other weight loss treatments report that they have not previously experienced the benefits of the combined phentermine/topiramate therapy.", "Patients report that they have no appetite, can resist food easily, can concentrate and function at work (even in attention-intensive jobs such as computer programming), have more energy and feel better.", "Patients also report experiencing fewer side effects than any previous weight loss treatments tried.", "Example 2 Extended results of the trial described in Example 1.A total of thirteen patients were treated for 1-9 months with phentermine (15 mg daily) in the morning and up to 400 mg of topiramate (median dose 200 mg), in the evening.", "[Note: Patient D.M.", "(B) discussed above is not included in this data as he was on phentermine treatment prior to treatment with the combination therapy of the present invention.]", "Topiramate dose was gradually increased from 25 mg per day in increments of 25-50 mg weekly until either desirable weight loss took place or until side effects limited dose increases.", "[Note: A fourteenth patient discontinued treatment after 3 days due to nausea.]", "All thirteen patients tolerated treatment well with minimal side effects.", "Along with taking medication, patients were instructed to walk at least 30 minutes three times per week and to follow a low fat diet.", "No patients had taken diet medication for at least 3 months prior to treatment.", "Average baseline BMI was 32.5 (range 26-48).", "Average weight loss for the thirteen patients was 11.8%.", "For seven patients who were on treatment the longest (range 5-9 months), the average weight loss was 14.4%.", "Patients reported that they had little or no appetite and that they actually felt better (Topiramate's usefulness is also being investigated as a mood stabilizer) than before therapy.", "Blood pressure, lipid, glucose, and Hgb A1C values were also favorably affected by this treatment.", "Table III sets forth patient data for the thirteen above-described patients treated with the combination therapy of the present invention.", "TABLE III Patient Data: Combination Therapy* % of Patient Weight Baseline Current Weeks on Current No.", "Loss BMI BMI Rx Status 1 7.7 38 35 10 on Rx 2 10.3 25 23 4 Finished 3 6.8 48 44 5 d/c early-dropped out 4 16.8 30 24 35 on taper 5 23.2 30 23 41 on taper 6 8 41 38 40 on Rx 7 9.7 28 25 33 on taper 8 14.4 30 26 44 on Rx 9 15.9 27 21 32 on taper 10 9 33 31 7 d/c early-will restart 11 12.9 28 24 22 Finished 12 7 29 27 5 on Rx 13 12.1 34 31 6 on Rx *data for thirteen patients Average weight loss = 11.8% (13 patients) Average weight loss ≥22 weeks on Rx = 14.4% (7 patients) Average baseline BMI = 32.4 Table IV sets forth for the average blood pressure, blood glucose, Hgb A1C and blood lipid value for the thirteen patients.", "TABLE IV BP GLUCOSE HGBA1C CHOL TRIG mmHg mg/dL %* mg/dL mg/dL Average Pre- 131.3/ 107 6.48 212 189 Treatment Value 85.9 Average On 122.6/ 102 5.05 210 172 Treatment Value 78.4 *Numbers include 1 diabetic patient whose oral hypoglycemic was reduced by 50% while on the weight loss treatment.", "One of the thirteen patients in the study also had severe sleep apnea with the usual complications of daytime sleepiness and fatigue.", "His symptoms have disappeared with the weight loss treatment.", "Of the six patients (i.e., finished or on taper) who have completed the combination therapy of the present invention, five of the six achieved a body mass index (BMI) of 24 or better.", "The average pre-treatment or baseline BMI for these six patients was 28.The final average BMI was 23.3.The average weight loss was 17%.", "Example 3 The 56-year old male patient described previously (D.M.", "(B)) who was initially taking phentermine alone and had topiramate added to his regimen had a good effect from the combination.", "He once weighed as much as 395 pounds.", "When Redux was still on the mark in the United States, he was treated with a combination of diet, exercise, Redux and phentermine.", "His lowest weight attained was 285 pounds.", "When Redux was withdrawn from the market, he remained on phentermine but gained weight back to 295-300 pounds.", "When topiramate was added to his regimen, he managed to lose 25 pounds and is currently at 271 pounds, his lowest weight since he was in his 20s.", "He, along with most of the patients treated so far, reported that the treatment with topiramate and phentermine had fewer side effects and was more effective than any previous weight loss treatment using medications that he and others had tried.", "This 56-year old man exhibited lowered blood pressure (approx.", "15 mm Hg systolic and 10 mm Hg diastolic).", "Example 4 Extended results of the trial described in Examples 1 and 2.The cumulative data from a total of seventeen patients treated with the combination weight loss treatment of the present invention are set forth in Table V. TABLE V Patient Data: Combination Therapy* % BASE- WEEKS WEIGHT LINE CURRENT ON CURRENT PATIENT LOSS BMI BMI Rx STATUS 1 7.7 38 35 33 on Rx 2 10.3 25 23 4 Finished 3 6.8 48 44 5 d/c early- dropped out 4 16.8 30 24 58 on taper 5 23.2 30 23 64 on taper 6 17.5 41 33 63 on Rx 7 9.7 28 25 56 on taper 8 18.6 30 24 67 on Rx 9 15.9 27 21 55 on taper 10 9 33 31 7 d/c early- will restart 11 12.9 28 24 22 Finished 12 7 29 27 5 d/c early- will restart 13 12.1 34 31 6 d/c early- will restart 14 22.5 46 32 16 on Rx 15 10.1 50 45 12 on Rx 16 6.4 27 24 4 Finished 17 6.3 27 25 6 on Rx *data for seventeen patients AVERAGE WEIGHT LOSS = 12.5% (17 patients) AVERAGE WEIGHT LOSS ≥22 WEEKS ON Rx = 15.3% (8 patients) AVERAGE BASELINE BMI = 33.6 The present invention provides a novel combination therapy for the treatment of obese or overweight patients that can result in weight losses of greater than 5-10%, perhaps even as great as 15-20%.", "The therapy combines phentermine or a phentermine-like drug with drug previously recognized for the treatment of epileptic seizures, known as topiramate.", "The combination therapy results in greater initial weight loss than other recognized therapies, potential greater overall weight loss and can be continued for significant periods of time with fewer and less serious side effects than other recognized weight loss treatments.", "In particular, the combination therapy far surpasses the modest anorexient effects of phentermine monotherapy and can be continued for significant periods of time without the loss of effectiveness experienced by patients being treated with phentermine alone.", "Moreover, the combination therapy has been found to ameliorate symptoms associated with Syndrome X and accordingly, has potential use in the treatment of Syndrome X. EQUIVALENTS Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein.", "Such equivalents are intended to be encompassed by the following claims." ] ]
Patent_15872591
[ [ "ANTIBODIES THAT BIND TO TL1A AND METHODS OF TREATING INFLAMMATORY OR AUTOIMMUNE DISEASE COMPRISING ADMINISTERING SUCH ANTIBODIES", "Methods and compositions for treating inflammatory or autoimmune diseases in a subject comprising blocking the interaction between DR3 and TL1A.", "In the methods of treating inflammatory or autoimmune disease, the inflammatory or autoimmune disease can be an autoimmune disease with a T cell component, including asthma, multiple sclerosis, rheumatoid arthritis, type 1 diabetes, graft versus host disease or inflammatory bowel disease." ], [ "1.A nucleic acid encoding a monoclonal antibody or antigen-binding fragment thereof that specifically binds to TL1A.", "2.The nucleic acid according to claim 1 which encodes an immunoglobulin heavy chain comprising a variable region amino acid sequence which is at least 90% identical to SEQ ID NO:34, wherein the antibody specifically binds to TL1A.", "3.The nucleic acid according to claim 1 which encodes an immunoglobulin light chain comprising a variable region amino acid sequence which is at least 90% identical to SEQ ID NO:42, wherein the antibody specifically binds to TL1A.", "4.The nucleic acid according to claim 1 which encodes an immunoglobulin heavy chain comprising a variable region amino acid sequence set forth in SEQ ID NO:34 and an immunoglobulin light chain comprising a variable region amino acid sequence set forth in SEQ ID NO:42.5.The nucleic acid according to claim 1 which encodes an scFv.", "6.The nucleic acid according to claim 1 which encodes an immunoglobulin heavy chain comprising a variable region amino acid sequence set forth in SEQ ID NO:34 and an immunoglobulin light chain comprising a variable region amino acid sequence set forth in SEQ ID NO:42.7.The nucleic acid according to claim 1, which encodes a humanized monoclonal antibody.", "8.The nucleic acid according to claim 1, which comprises the nucleic acid sequence of SEQ ID NO:33.9.The nucleic acid according to claim 1, which comprises the nucleic acid sequence of SEQ ID NO:41.10.The nucleic acid according to claim 1, which comprises the nucleic acid sequences of SEQ ID NO:33 and SEQ ID NO:41.11.The nucleic acid according to claim 1, which comprises the nucleic acid sequences of SEQ ID NO:35, SEQ ID NO:37, and SEQ ID NO:39.12.The nucleic acid according to claim 1, which comprises the nucleic acid sequences of SEQ ID NO:43, SEQ ID NO:45, and SEQ ID NO:47.13.A method of treating an inflammatory or autoimmune disease in a subject, comprising administering to the subject an effective amount of a nucleic acid according to claim 1, wherein the autoimmune disease is selected from asthma, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes, graft versus host disease, and autoimmune disease with a T cell component.", "14.The method according to claim 13, wherein the nucleic acid comprises the nucleic acid sequence of SEQ ID NO:33.15.The method according to claim 13, wherein the nucleic acid comprises the nucleic acid sequence of SEQ ID NO:41.16.The method according to claim 13, wherein the nucleic acid comprises the nucleic acid sequences of SEQ ID NO:33 and SEQ ID NO:41.17.The method according to claim 13, wherein the nucleic acid comprises the nucleic acid sequences of SEQ ID NO:35, SEQ ID NO:37, and SEQ ID NO:39.18.The method according to claim 13, wherein the nucleic acid comprises the nucleic acid sequences of SEQ ID NO:43, SEQ ID NO:45, and SEQ ID NO:47.19.A vector comprising a nucleic acid according to claim 1.20.The vector of claim 19, that is an adenovirus vector." ], [ "<SOH> BACKGROUND <EOH>DR3 (TRAMP, LARD, WSL-1, TNFRSF25) is a tumor necrosis receptor family member expressed specifically on T cells that is most similar to TNFR1.The ligand for DR3 is TL1A, a TNF family member protein reported to be expressed by endothelial cells.", "TL1A can costimulate T cell activation in vitro, but the physiological sources of TL1A and its in vivo role in peripheral T cell biology are not known.", "Interactions between numerous TNF family ligands and receptors play an important role in shaping specific features of T cell responses.", "A subfamily of TNF receptors including CD30, TNFR2, OX40, CD27, GITR, HVEM, and 4-1BB are expressed on T cells and mediate distinct aspects of costimulation in specific T cell subsets (Croft, 2003).", "For example, OX40 potentiates post-activation survival of activated CD4+ T cells (Croft), TNFR2 costimulates CD8+ T cell activation, and GITR has a unique role in regulatory T cells.", "DR3 (TNFRSF25/TRAMP/LARD/WSL-1) is a death domaincontaining TNF-family receptor that, like its closest homolog TNFR1, recruits TRADD and has the ability to activate NF-kB and MAP-Kinases or, alternatively, trigger caspase activation and programmed cell death on the cellular context.", "Unlike TNFR1, DR3 is specifically expressed in lymphocytes with the highest levels on T cells.", "However, the function of this receptor in T cell homeostasis is not well understood, particularly since the authentic ligand for this receptor, TL1A, was only recently identified.", "Initial reports suggested that TL1A was expressed exclusively on endothelial cells, and addition of exogenous TL1A was reported to costimulate IL-2 and IFN-γ production by human T cells stimulated though the TCR (Papadakis et al., 2004; Papadakis et al., 2005).", "More recently, TL1A has also been found at sites of inflammation such as in inflammatory bowel disease (Bamias et al., 2003; Bamias et al., 2006)." ], [ "<SOH> SUMMARY <EOH>In accordance with the purpose of this invention, as embodied and broadly described herein, this invention relates to compositions and methods for treating an inflammatory or autoimmune disease in a subject comprising blocking the interaction between DR3 and TL1A.", "Additional advantages of the disclosed method and compositions will be set forth in part in the description which follows, and, in part, will be understood from the description or may be learned by practice of the disclosed method and compositions.", "The advantages of the disclosed method and compositions will be realized and attained by means of the elements and combinations particularly pointed out in the appended claims.", "It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the invention as claimed." ], [ "PRIORITY DATA This application is a divisional of U.S. patent application Ser.", "No.", "14/931,149, filed Nov. 3, 2015, which is a continuation-in-part of U.S. application Ser.", "No.", "14/826,462, filed Aug. 14, 2015, now abandoned, which is a continuation of U.S. application Ser.", "No.", "14/733,695, filed Jun.", "8, 2015, now abandoned, which is a divisional of U.S. application Ser.", "No.", "13/419,203, filed Mar.", "13, 2012, now U.S. Pat.", "No.", "9,068,003, which is a continuation-in-part of U.S. application Ser.", "No.", "11/972,395, entitled “Blockade of TL1A-DR3 Interactions to Ameliorate T Cell Mediated Disease Pathology”, filed Jan. 10, 2008; which claims the benefit of U.S.", "Provisional Application No.", "60/879,668, filed Jan. 10, 2007, and also claims the benefit of U.S.", "Provisional Application No.", "61/488,671 filed May 20, 2011.The entire disclosure of each of these disclosures are hereby incorporated by reference.", "Any disclaimer that may have occurred during the prosecution of the above-referenced applications is hereby expressly rescinded, and reconsideration of all relevant art is respectfully requested.", "STATEMENT OF GOVERNMENT INTEREST The Government of the United States owns the invention(s) disclosed and claimed herein.", "SEQUENCE LISTING The Sequence Listing text file attached hereto, created Jan. 15, 2018 size 30000 bytes, and filed herewith as file name “6137NIAMS-2-C1-D1-1-C1-D1_Seq_Listing_ST25.txt” is incorporated herein by reference in its entirety.", "FIELD OF THE INVENTION The present invention relates to methods and compositions for treating disease in a subject comprising blocking the interaction between DR3 and TL1A, and compositions comprising the same.", "BACKGROUND DR3 (TRAMP, LARD, WSL-1, TNFRSF25) is a tumor necrosis receptor family member expressed specifically on T cells that is most similar to TNFR1.The ligand for DR3 is TL1A, a TNF family member protein reported to be expressed by endothelial cells.", "TL1A can costimulate T cell activation in vitro, but the physiological sources of TL1A and its in vivo role in peripheral T cell biology are not known.", "Interactions between numerous TNF family ligands and receptors play an important role in shaping specific features of T cell responses.", "A subfamily of TNF receptors including CD30, TNFR2, OX40, CD27, GITR, HVEM, and 4-1BB are expressed on T cells and mediate distinct aspects of costimulation in specific T cell subsets (Croft, 2003).", "For example, OX40 potentiates post-activation survival of activated CD4+ T cells (Croft), TNFR2 costimulates CD8+ T cell activation, and GITR has a unique role in regulatory T cells.", "DR3 (TNFRSF25/TRAMP/LARD/WSL-1) is a death domaincontaining TNF-family receptor that, like its closest homolog TNFR1, recruits TRADD and has the ability to activate NF-kB and MAP-Kinases or, alternatively, trigger caspase activation and programmed cell death on the cellular context.", "Unlike TNFR1, DR3 is specifically expressed in lymphocytes with the highest levels on T cells.", "However, the function of this receptor in T cell homeostasis is not well understood, particularly since the authentic ligand for this receptor, TL1A, was only recently identified.", "Initial reports suggested that TL1A was expressed exclusively on endothelial cells, and addition of exogenous TL1A was reported to costimulate IL-2 and IFN-γ production by human T cells stimulated though the TCR (Papadakis et al., 2004; Papadakis et al., 2005).", "More recently, TL1A has also been found at sites of inflammation such as in inflammatory bowel disease (Bamias et al., 2003; Bamias et al., 2006).", "SUMMARY In accordance with the purpose of this invention, as embodied and broadly described herein, this invention relates to compositions and methods for treating an inflammatory or autoimmune disease in a subject comprising blocking the interaction between DR3 and TL1A.", "Additional advantages of the disclosed method and compositions will be set forth in part in the description which follows, and, in part, will be understood from the description or may be learned by practice of the disclosed method and compositions.", "The advantages of the disclosed method and compositions will be realized and attained by means of the elements and combinations particularly pointed out in the appended claims.", "It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the invention as claimed.", "DESCRIPTION OF THE DRAWINGS The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate several embodiments of the disclosed method and compositions and, together with the description, serve to explain the principles of the disclosed method and compositions.", "FIGS.", "1A-1E show that TL1A mRNA expression is strongly induced in bone marrow-derived dentritic cells (DC) after various innate stimuli and is MyD88-dependent.", "FIG.", "1A shows Bone marrow-derived DCbone marrow-derived DC or CD11c+ DC were cultured and stimulated for the indicated time with or without 100 ng/ml of LPS, SEA, or STAg.", "FIG.", "1B shows TL1A mRNA expression in bone marrow-derived DC from various knock-out (KO−/−) mice in the presence or absence of 100 ng/ml of LPS for 3 h. RNA was prepared from each sample and used in quantitative PCR.", "Results indicate the amount of TL1A mRNA calculated relative to the resting cells of each population.", "FIG.", "1C shows purified T cells were cultured and stimulated with 5 μg/ml of anti-CD3/CD28 for the indicated time.", "RNA was prepared from each sample and used in quantitative PCR.", "Results indicate the amount of TL1A mRNA calculated relative to freshly purified T cells.", "FIG.", "1D shows TL1A mRNA induction in human Peripheral Blood Mononuclear Cells (PBMC) after T cell activation with anti-CD3/CD28.FIG.", "1E shows early peak in TL1A induction comes from non-T, non-B cells.", "The indicated cell types were purified from PBMC and stimulated as described.", "FIGS.", "2A-2D show that purified T cells from DR3 KO mice have reduced proliferation, activation marker expression, and altered cytokine production in DC-T co-culture.", "FIG.", "2A shows purified T cells were activated with anti-CD3 or anti-CD3/CD28 in presence or absence of 10 ng/ml rTL1A for 3 days.", "3H was added to the culture, incubated overnight, and analyzed for thymidine incorporation.", "FIG.", "2B shows purified T cells were activated with anti-CD3 or anti-CD3/CD28 in the presence or absence of 10 ng/ml rTL1A and 10 μg/ml of 3C7 antibody for 3 days.", "3H-thymidine was added to the culture, incubated overnight, and analyzed for thymidine incorporation.", "FIG.", "2C shows CFSE-labeled, purified T cells were activated with anti-CD3 or anti-CD3/CD28 in the presence or absence of 10 ng/ml rTL1A.", "Cells were analyzed by flow cytometry.", "FIG.", "2D shows supernatants from T cells activated by anti-CD3/CD28 were harvested and analyzed for the production of the indicated cytokines after 24 hours.", "FIGS.", "3A-3B show that DR3 KO T cells have reduced proliferation, activation marker expression, and altered cytokine production in DC-T co-culture.", "FIG.", "3A shows bone marrow DC were cultured with naïve OT-II or DR3 KO OTT-II T cells in the presence of indicated Ova peptide concentration for 3 days.", "3H was added to the culture, incubated overnight, and analyzed for thymidine incorporation.", "FIG.", "3B shows bone marrow DC were cultured with naïve OT-II or DR3 KO OTT-II T cells in the presence of indicated Ova peptide concentration.", "Cells were harvested after 24, 48, and 72 hours and stained for activation marker and analyzed by flow cytometry.", "Supernatants from co-culture were harvested at 24, 48, and 72 hours and tested for IL-2 production.", "FIGS.", "4A-4D show that TL1A can play a role in T cell differentiation.", "FIG.", "4A shows purified naïve T cells stimulated with anti-CD3/CD28 were cultured under Th1 (anti-IL-4+IL-12) or under Th2 (anti-IFN-γ+IL-4) conditions for 6 days.", "Cells were then restimulated with anti-CD3/CD28 for 5-6 h and stained for intracellular cytokines and analyzed by flow cytometry.", "B-sorted CD11c+ DC were cultured with OT-II or DR3-OT-II T cells in presence of Ova peptide with either SEA, STAg, or IL-12 for 6 days.", "Cells were then restimulated with PMA/ionomycin for 6 h and stained for intracellular cytokines and analyzed by flow cytometry.", "FIGS.", "5A-5D show that DR3 KO mice have reduced lung histopathology in an Ova-mediated asthma model.", "Mice were sensitized with Alum+PBS (control) or Alum+Ova.", "Mice were then challenge with PBS (control) or Ova.", "FIG.", "5A shows histology of the lungs was performed with PAS staining.", "FIG.", "5B shows histopathology of the lungs scored.", "FIG.", "5C shows RNA prepared from lungs and used in quantitative PCR.", "Results indicate the amount of cytokine mRNA calculated relative to the lungs of the control mice treated with PBS (right panel).", "Spleens of the Ova-mediated asthma model mice were harvested, and splenocytes were cultured in the absence or presence of either 10 μg/ml or 50 μg/ml Ova protein for 3 days.", "3H was added to the culture, incubated overnight, and analyzed for thymidine incorporation.", "The supernatant of the splenocytes cultured with 50 μg/ml was harvested after 3 days and analyzed for cytokines (left panel).", "FIG.", "5D shows blood of the Ova-mediated asthma model mice harvested and the serum tested for IgG1 and Ova specific IgG1 level by ELISA.", "FIGS.", "6A-6D show that DR3 KO mice have reduced EAE in a MOG-EAE model.", "FIG.", "6A shows the clinical score.", "FIG.", "6B shows spleen, non-draining, and draining lymph nodes cultured and restimulated with MOG.", "3H was added to the culture, incubated overnight, and analyzed for thymidine incorporation, or cells were restimulated for 6 h with PMA/ionomycin and stained for IL-17 and IFNγ (FIG.", "6C).", "FIG.", "6D shows cells from spinal cord were restimulated with PMA/ionomycin for 6 h and stained for IL-17 and IFNγ.", "FIGS.", "7A-7B show increased T cell activation and spontaneous inflammatory bowel disease in CD2-TL1A transgenic mice in which mouse TL1A has been placed under the control of the human CD2 T cell-specific regulatory element.", "FIG.", "7A shows increased CD44 expression in T cells isolated from three independent founder lines of CD2-TL1A transgenic mice.", "FIG.", "7B shows representative Gross (top), low power H&E section (middle), and high power H&E section (bottom) images of ileum from CD2-TL1A transgenic mice and littermate controls (WT).", "Bowel wall thickening, destruction of villi, and infiltration of inflammatory cells into the mucosa can be seen.", "FIGS.", "8A-8C show TL1A co-stimulates proliferation and cytokine production in CD4+ T Cells through DR3.FIG.", "8A shows purified CD4+ T cells from C57BL/6 or DR3 KODR3 KO mice were activated with anti-CD3 or anti-CD3 and anti-CD28 in the presence or absence of 10 ng/ml mouse rTL1A for 3 days.", "3H-thymidine was added to the culture, incubated overnight, and analyzed for thymidine incorporation.", "Error bars represent s.e.m.", "of triplicate samples.", "FIG.", "8B shows purified T cells from C57BL/6 cultured as above, but also in the presence of 10 μg/ml anti-IL-2Rα antibody or isotype control for 3 days (left panel).", "Purified T cells from IL-2−/− or IL-2+/+ were cultured as above, in the absence or presence 10 U/ml IL-2 for 3 days (middle and right panels).", "Error bars represent s.e.m.", "of triplicate samples.", "FIG.", "8C shows supernatants from CD4+ T cells activated and cultured as in FIG.", "8A, harvested at the indicated time points, with the indicated cytokines measured with cytokine bead arrays; n.d.=below limit of detection (4 pg/ml).", "FIGS.", "9A-9D show differential induction of TL1A expression in dendritic cells and T cells.", "FIG.", "9A shows bone marrow-derived DC or CD11c+ DC from wild-type C57BL/6 mice cultured and stimulated for the indicated time with or without 100 ng/ml LPS, 20 μg/ml SEA, or 10 μg/ml STAg.", "RNA was prepared from each sample and used in reverse-transcriptase quantitative PCR (RT-qPCR).", "FIG.", "9B shows bone marrow-derived DC from wild-type C57BL/6 or the indicated knock-out (KO) mice cultured and stimulated in the presence or absence of 100 ng/ml LPS for 3 hours.", "RNA was prepared from each sample and used in RT-qPCR.", "FIG.", "9C shows bone marrow-derived DC from wild-type C57BL/6 cultured and stimulated for the indicated times with or without 100 ng/ml LPS, or Ig cross-linking, and RNA prepared from each sample and used in RT-qPCR.", "FIG.", "9D shows purified T cells from wild-type C57BL/6 or DR3 KO mice cultured and stimulated with 5 μg/ml anti-CD3 and anti-CD28 for the indicated time.", "RNA was prepared from each sample and used in RT-qPCR.", "Results indicate the amount of TL1A mRNA calculated relative to the untreated cells of each population (FIG.", "9A-C), or relative to unstimulated T cells of each genotype (FIG.", "9D).", "TL1A basal mRNA levels in T cells were approximately 50-fold lower than in DC.", "Error bars represent s.e.m.", "of triplicate samples.", "FIGS.", "10A-10B show that DR3 KO T cells have reduced proliferation and altered cytokine production when cultured in the presence of dendritic cells.", "FIG.", "10A shows bone marrow DC cultured with naïve OT-II or DR3 KO OT-II CD4+ T cells in the presence of the indicated Ova peptide concentration, and in the absence (left panel) or presence (right panel) of CTLA4Ig for 3 days.", "3H-thymidine was added to the culture, incubated overnight, and analyzed for thymidine incorporation.", "FIG.", "10B shows supernatants from the above cultures harvested after 72 hours and tested for cytokine production.", "n.d.=below limit of detection (4 pg/ml).", "FIGS.", "11A-11B show that DR3 is not required for Th1, Th2, or Th17 differentiation of naïve T cells.", "FIG.", "11A shows T-depleted APC cultured with C57BL/6 or DR3 KO purified naïve CD4+ T cells in the presence of soluble anti-CD3 and anti-CD28 under Th0, Th1, Th2, or Th17 polarization conditions for 4 days.", "Cells were then restimulated with PMA and Ionomycin for 5-6 hours, stained for intracellular cytokines, and analyzed by flow cytometry.", "FIG.", "11B shows sorted CD11c+ DC cultured with OT-II or DR3 KO OT-II purified naïve CD4+ T cells in the presence of Ova peptide under Th0, Th1, or Th2 polarization conditions or in the presence of STAg for 6 days.", "Cells were then restimulated with anti-CD3 and anti-CD28 for 5-6 hours, stained for intracellular cytokines, and analyzed by flow cytometry.", "FIGS.", "12A-12F show that DR3 is required for Th2-mediated lung inflammation.", "Mice were sensitized with Alum+PBS (control) or Alum+Ova.", "Mice were then challenged with PBS (control) or Ova.", "FIG.", "12A shows examples of PAS-stained histology with airways (aw) and infiltrating cells (arrowheads).", "FIG.", "12B shows histopathology of the lungs scored (top panel) and cells in the BAL counted (bottom panel).", "FIG.", "12C shows cells extracted from the lungs and analyzed by flow cytometry (FIG.", "12D).", "RNA was prepared from lungs and used in RT-qPCR.", "Results indicate the amount of cytokine mRNA calculated relative to the lungs of control mice treated with PBS.", "P values are for unpaired t-tests on mRNA levels of the indicated cytokines between DR3 KO and control mice induced with Ova.", "FIG.", "12E shows splenocytes cultured in the presence of 50 μg/ml Ova protein or media control for 3 days.", "Supernatants were analyzed for cytokine production by cytometric bead array.", "FIG.", "12F shows serum tested for Ova-specific IgE and Ova-specific IgG1 levels by ELISA.", "P values obtained by comparing groups with an unpaired two-tailed T test are shown where significant; n.s.=not significant.", "FIGS.", "13A-13D show that DR3 KO mice have defective local T cell responses and reduced disease in EAE.", "FIG.", "13A shows DR3 KO mice and C57BL/6 control mice induced for EAE as described below and clinical scores measured daily.", "FIG.", "13B shows draining lymph nodes from the site of MOG injection harvested and cells restimulated with the indicated amounts of MOG peptide.", "T cell proliferation was assessed by 3H-thymidine incorporation after 3 days.", "FIG.", "13C shows cells harvested from spinal cords restimulated for 4 hours with anti-CD3 and anti-CD28 and analyzed by flow cytometry for T cell surface markers, and gated CD4+CD45+ cells were analyzed for intracellular cytokine production.", "FIG.", "13D shows mRNA from spinal cord or spleen from the indicated groups of mice analyzed by RT-qPCR for IL-17 and IFN-γ mRNA.", "Results are normalized to β2m or CD3-8.Error bars represent s.e.m of triplicate samples.", "FIG.", "14 shows a normal systemic response to T. gondii.", "The indicated mice were inoculated i.p.", "with an average of 20 cyst/animal.", "After 7 weeks, spleen cells were harvested, cultured with anti-CD3 and anti-CD28 or with STAg for 48 hours, and supernatants were tested for the production of the indicated cytokines.", "FIGS.", "15A-15B show T cell-specific DR3 expression in humans and mice.", "Microarray-derived gene expression data on DR3 (TNFRSF25) from SymAtlas (symatlas.gnf.org) (Su et al., 2004) are shown for a variety of cell types from mouse (FIG.", "15A) and human (FIG.", "15B) tissues.", "Data are normalized by the gcRMA algorithm.", "FIG.", "16 shows kinetics of surface marker expression after activation of DR3 KO and WT T Cells.", "Purified CD4+ T cells from C57BL/6 or DR3 KO mice were activated with 1 μg/ml anti-CD3 in the presence or absence of 10 ng/ml mouse rTL1A.", "Cells were stained for the indicated activation markers before stimulation and after 24, 48, and 72 hours and measured by flow cytometry.", "FIGS.", "17A-17C show the effects of TL1A on Naïve T Cells.", "FIG.", "17A shows purified naïve (CD62LhiCD44lo) CD4+ T cells from C57BL/6 or DR3 KO mice activated with anti-CD3 in the presence or absence of 10 ng/ml mouse rTL1A for 3 days.", "3H-thymidine was added to the culture, incubated overnight, and analyzed for thymidine incorporation.", "FIG.", "17B shows supernatants from naïve CD4+ T cells cultured as above, harvested after 3 days, and analyzed for cytokine production.", "FIG.", "17C shows spleen and lymph nodes (mLN) from C57BL/6 or DR3 KO mice analyzed for memory population by determining CD44 expression in CD4+ T cells.", "FIG.", "18 shows surface marker expression after activation of DR3 KO and WT OT-II T cells with Ova peptide-pulsed DC.", "Bone marrow-derived DC were cultured with naïve OT-II or DR3 KO OT-II CD4+ T cells in the presence of the indicated concentration of Ova peptide.", "Cells were stained for CD4 and the indicated surface expression markers after 24 and 48 hours and analyzed by flow cytometry.", "FIG.", "19 shows altered localization of T cells and macrophages in Ova-induced lung inflammation.", "Histological sections of lungs from mice of the indicated genotype, primed and challenged with Ova as described below, were subjected to immunohistochemical labeling with anti-CD3 (T cells) or anti-F4/80 (macrophage) marker antibodies and HRP-conjugated secondary antibodies.", "Airways (aw) and blood vessels (bv) are indicated.", "FIGS.", "20A-20E show characterization of functional anti-TL1A blocking antibodies.", "FIGS.", "20A-D show flow cytometric staining of cells transfected with mouse TL1A-GFP fusion protein.", "FIG.", "20A is a negative control mAb.", "FIGS.", "20B and 20C are two positive anti-TL1A clones.", "FIG.", "20D is a positive clone reacted with cells transfected with GFP alone.", "FIG.", "20E shows blockade of TL1A-induced apoptosis in the RPMI 8826 cell line.", "100 ng/ml TL1A+Cycloheximide (CHX) was added to RPMI-8826 B lymphoma cells, and cellular viability was measured 24 hours later with an MTT assay.", "Viability was normalized to 100% for medium alone.", "Anti-TL1A antiserum was used at 1:1000 dilution.", "FIGS.", "21A-21E show inflammatory bowel disease in TL1A transgenic mice.", "FIG.", "21A shows gross (top row), low (middle row), and high (bottom row) power magnification of sections of ileum from Wild-type (WT), TL1A-CD2 line R6 (R6) and TL1A CD11c line 14 (I4) transgenic mice.", "FIGS.", "21B and 21C show summaries of histopathological IBD scores of the indicated regions of CD2-TL1A and CD11c-TL1A transgenic mice.", "FIG.", "21D shows weight gain in the three weeks following weaning in the indicated groups of mice.", "FIG.", "21E shows relative levels of RNA for the indicated cytokines in ileum from CD2-TL1A transgenic mice measured with quantitative RT-PCR and normalized to an average of 1 in wild-type mice.", "FIG.", "22 shows the screening strategy for anti-TL1A antibodies using 293T cells transfected with TL1A fused with Green Fluorescent Protein (GFP).", "An example is shown from the screening of antibodies against murine TL1A (mTL1A).", "Armenian Hamsters were immunized with murine recombinant TL1A.", "Hybridomas were screened by flow cytometry with 293T cells transfected with murine TL1A.", "An example is shown for a positive clone.", "Also shown is an example staining of mTL1A by the indicated quantities of the two clones selected for further analysis is shown.", "The same strategy with 293T cells expressing human TL1A was used for screening hybridomas from mice immunized with human recombinant TL1A to select anti-human TL1A clones 1A9 and 106, which are mIgG2a kappa isotype antibodies.", "FIG.", "23 shows wild-type or TL1A transgenic (Tg) mouse T cells activated with anti-CD3/anti-CD28 for 24 hours and then stained with anti-TL1A mAb 5G4.6 to demonstrate recognition of surface TL1A by this mAb on the indicated cell types (as indicated in the legend).", "The grey shaded plots represent background levels of fluorescence using hamster Ig as a control staining reagent.", "FIG.", "24 shows the sensitivity curve for a bead-based assay for detection of human TL1A in body fluids and culture supernatants using anti-human TL1A mAb 1A9.FIG.", "25 shows anti-TL1A mAb blocking cell death mediated by mouse and human TL1A in TF-1 cells in a species-specific manner.", "TF1 erythroleukemia cells treated with murine (A) or Human (B) TL1A+Cycloheximide (CHX) in the presence of the indicated mAb are shown.", "Cell viability was measured by the Promega CellTiter-Glo® ATP reagent.", "A change in luminescence indicates cell death, a known response to TL1A+CHX in these cells.", "Reduction in the change in luminescence indicates blockade of TL1A action by the mAb.", "These mAb were also shown not to cross-react between human and mouse TL1A.", "FIG.", "26 shows prevention of TNBS colitis with anti-mouse TL1A mAb.", "Panel A) Weight loss in a cohort of mice induced to develop TNBS colitis with intra-rectal administration of trinitrobenzene sulphonic acid (TNBS) at day 0.10 mg/kg anti-TL1A mAb 5G4.6 or control hamster IgG was injected i.p on days −1 and 0.Each point represents the average weight of the cohort.", "Mice that died before the end of the experiment are indicated with arrows.", "Data is representative of two independent experiments with a minimum of 8 mice per group.", "Panel B) Representative H&E sections of the colon from mice induced to develop TNBS colitis treated with control or anti-TL1A mAb as in (A).", "The control Ab-treated mouse showed area of severe inflammation.", "Left panels are 50×, and right panels 200×, enlargements of the same sections.", "Average pathology scores of the mice in (A) at day 6 after induction of colitis are indicated.", "FIG.", "27 shows prevention of Collagen-Induced Arthritis (CIA) by anti-mouse TL1A mAb 5G4.6.Panel A. CIA was induced in DBA/1 mice by standard methods.", "Weekly intra-peritoneal injections of 20 mg/kg of either anti-TL1A mAb 5G4.6 (treatment, n=5) or hamster immunoglobulin (control, n=7) were begun at day 21 after initial immunization with collagen.", "Representative results of three independent experiments are shown.", "Clinical scores on each day were compared using an unpaired t-test, and p values for significance are shown above each time-point represented by asterisks (*=p<0.05, **=p<0.005) above each date.", "2-way ANOVA was also performed to compare the trend of the two graphs, with p values shown to the right of each experiment.", "Panel B.", "Survival analysis of the percentage of mice without arthritis on each day is compared between the anti-TL1A-treated group and the control group.", "Arthritis was defined by a combined clinical score of two or more.", "Panel C. Sera from mice from each group induced to develop CIA as in panel A were collected at indicated time points and anti-chicken collagen IgG levels were measured by ELISA.", "FIG.", "28 shows that blocking TL1A with anti-mouse TL1A mAb 5G4.6 reduces bony erosions independently of joint scores in CIA.", "Panel A) Hind paws from mice induced to develop CIA as described below were harvested and fixed in 10% formaldehyde.", "Paws were scanned by micro-CT and images reconstructed as described below.", "Examples are shown from each treatment group, with the maximum clinical scores and the erosion score obtained for that paw by two separate observers blinded to treatment groups.", "Panel B) Erosion scores obtained by two separate observers blinded to clinical scores were averaged for each sample.", "Shown here is the composite of the scores from the anti-TL1A mAb 5G4.6-treated group (n=18) and control antibody-treated group (n=20), with the p value from an unpaired t-test with Welch's correlation (*p=0.05).", "Analysis of individual regions resulted in p values of 0.078 at ankle/tarsus, 0.042 at metatarsophalangeal (MTP) joints, and 0.015 at toes.", "Panel C) Comparison of the CT scores of the paws from the two groups based on the maximum clinical scores.", "Anti-TL1A mAb treatment significantly reduced erosions independent of the clinical score.", "P<0.0001 using 2-way ANOVA (***p<0.0001).", "DETAILED DESCRIPTION The disclosed methods and compositions may be understood more readily by reference to the following detailed description of particular embodiments and the examples included therein and to the Figures and their previous and following description.", "Disclosed are materials, compositions, and components that can be used for, can be used in conjunction with, can be used in preparation for, or are products of the disclosed methods and compositions.", "These and other materials are disclosed herein, and it is understood that when combinations, subsets, interactions, groups, etc.", "of these materials are disclosed, while specific reference of each of the various individual and collective combinations and permutation of these compounds may not be explicitly disclosed, each is specifically contemplated and described herein.", "For example, if a peptide is disclosed and discussed, and a number of modifications that can be made to a number of molecules including the peptide are discussed, each and every combination and permutation of peptide and the modifications that are possible are specifically contemplated unless specifically indicated to the contrary.", "Thus, if a class of molecules A, B, and C are disclosed, as well as a class of molecules D, E, and F and an example of a combination molecule, A-D, is disclosed, then even if each is not individually recited, each is individually and collectively contemplated.", "Thus, in this example, each of the combinations A-E, A-F, B-D, B-E, B-F, C-D, C-E, and C-F are specifically contemplated and should be considered disclosed from disclosure of A, B, and C; D, E, and F; and the example combination A-D.", "Likewise, any subset or combination of these is also specifically contemplated and disclosed.", "Thus, for example, the sub-group of A-E, B-F, and C-E are specifically contemplated and should be considered disclosed from disclosure of A, B, and C; D, E, and F; and the example combination A-D.", "This concept applies to all aspects of this application including, but not limited to, steps in methods of making and using the disclosed compositions.", "Thus, if there are a variety of additional steps that can be performed, it is understood that each of these additional steps can be performed with any specific embodiment or combination of embodiments of the disclosed methods, and that each such combination is specifically contemplated and should be considered disclosed.", "The meanings of abbreviations used are as follows: “BSA” means bovine serum albumin, “ELISA” means enzyme linked immunosorbent assay, “CIH” means collagen-induced arthritis, “SF” means synovial fluid, “microCT” means microtomography, “APC” means antigen-presenting cells, “WIT” means wild-type, “KO” means knockout, “DC” means dendritic cells, “RIA” means radioimmunoassay, “RIPA” means radioimmune precipitation assays, “FRET” means fluorescence resonance energy transfer, “FRAP/FLAP” means fluorescence recovery/localization after photobleaching, “FACS” means fluorescence activated cell sorting, “RT-PCR” means real time polymerase chain reaction, “LPS” means lipopolysaccharide, “FADD” means Fas-Associated protein with Death Domain, “BALF” means bronchoalveolar lavage fluid.", "Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the method and compositions described herein.", "Such equivalents are intended to be encompassed by the following claims.", "It is understood that the disclosed methods and compositions are not limited to the particular methodology, protocols, and reagents described as these may vary.", "It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the scope of the present invention, which will be limited only by the appended claims.", "A.", "Methods of Treatment Provided is a method of treating an inflammatory or autoimmune disease in a subject comprising blocking the interaction between DR3 and TL1A.", "The interaction between DR3 and TL1A can be blocked by reducing endogenous DR3 levels, activity, or availability.", "The interaction between DR3 and TL1A can also be blocked by reducing endogenous TL1A levels, activity, or availability.", "The interaction between DR3 and TL1A can be blocked using agents that directly interfere with the interaction between the two molecules.", "For example, direct interference can be affected by an agent that binds to DR3 at its binding site for TL1A or an agent that binds to TL1A at its binding site for DR3.Typically, this binding would competitively interfere with the ability of the other molecule to bind at that site.", "Protein levels, activity, or availability can be affected by modulating, for example, the transcription, translation, translocation, ubiquitination, phosphorylation, glycosylation, or propeptide cleavage of the peptide.", "i. Functional Nucleic Acids For example, endogenous levels of TL1A can be reduced using functional nucleic acids, such as antisense, RNAi, siRNA, ribozymes, or aptamers.", "Functional nucleic acids are nucleic acid molecules that have a specific function, such as binding a target molecule or catalyzing a specific reaction.", "Functional nucleic acid molecules can be divided into the following categories, which are not meant to be limiting.", "For example, functional nucleic acids include antisense molecules, aptamers, ribozymes, triplex forming molecules, RNAi, and external guide sequences.", "The functional nucleic acid molecules can act as affectors, inhibitors, modulators, and stimulators of a specific activity possessed by a target molecule, or the functional nucleic acid molecules can possess a de novo activity independent of any other molecules.", "Functional nucleic acid molecules can interact with any macromolecule, such as DNA, RNA, polypeptides, or carbohydrate chains.", "Thus, functional nucleic acids can interact with the mRNA of TL1A or the genomic DNA of TL1A, or they can interact with the polypeptide TL1A.", "Alternatively, functional nucleic acids can interact with the mRNA of DR3 or the genomic DNA of TR,3 or they can interact with the DR3 polypeptide.", "Often, functional nucleic acids are designed to interact with other nucleic acids based on sequence homology between the target molecule and the functional nucleic acid molecule.", "In other situations, the specific recognition between the functional nucleic acid molecule and the target molecule is not based on sequence homology between the functional nucleic acid molecule and the target molecule but, rather, is based on the formation of tertiary structure that allows specific recognition to take place.", "Antisense molecules are designed to interact with a target nucleic acid molecule through either canonical or non-canonical base pairing.", "The interaction of the antisense molecule and the target molecule is designed to promote the destruction of the target molecule through, for example, RNAseH-mediated RNA-DNA hybrid degradation.", "Alternatively, the antisense molecule is designed to interrupt a processing function that normally would take place on the target molecule, such as transcription or replication.", "Antisense molecules can be designed based on the sequence of the target molecule.", "Numerous methods for optimization of antisense efficiency by finding the most accessible regions of the target molecule exist.", "Exemplary methods would be in vitro selection experiments and DNA modification studies using DMS and DEPC.", "It is preferred that antisense molecules bind the target molecule with a dissociation constant (Kd) less than or equal to 10−6, 10−8, 10−10, or 10−12.A representative sample of methods and techniques which aid in the design and use of antisense molecules can be found in U.S. Pat.", "Nos.", "5,135,917, 5,294,533, 5,627,158, 5,641,754, 5,691,317, 5,780,607, 5,786,138, 5,849,903, 5,856,103, 5,919,772, 5,955,590, 5,990,088, 5,994,320, 5,998,602, 6,005,095, 6,007,995, 6,013,522, 6,017,898, 6,018,042, 6,025,198, 6,033,910, 6,040,296, 6,046,004, 6,046,319, and 6,057,437.Aptamers are molecules that interact with a target molecule, preferably in a specific way.", "Typically, aptamers are small nucleic acids ranging from 15-50 bases in length that fold into defined secondary and tertiary structures, such as stem-loops or G-quartets.", "Aptamers can bind small molecules, such as ATP (U.S. Pat.", "No.", "5,631,146) and theophiline (U.S. Pat.", "No.", "5,580,737), as well as large molecules, such as reverse transcriptase (U.S. Pat.", "No.", "5,786,462) and thrombin (U.S. Pat.", "No.", "5,543,293).", "Aptamers can bind very tightly with Kd's from the target molecule of less than 10−12 M. It is preferred that the aptamers bind the target molecule with a Kd less than 10−6, 10−8, 10−10, or 10−12.Aptamers can bind the target molecule with a very high degree of specificity.", "For example, aptamers have been isolated that have greater than a 10,000-fold difference in binding affinities between the target molecule and another molecule that differ at only a single position on the molecule (U.S. Pat.", "No.", "5,543,293).", "It is preferred that the aptamer have a Kd with the target molecule at least 10, 100, 1000, 10,000, or 100,000 fold lower than the Kd with a background binding molecule.", "It is preferred when doing the comparison for a polypeptide, for example, that the background molecule be a different polypeptide.", "Representative examples of how to make and use aptamers to bind a variety of different target molecules can be found in U.S. Pat.", "Nos.", "5,476,766, 5,503,978, 5,631,146, 5,731,424, 5,780,228, 5,792,613, 5,795,721, 5,846,713, 5,858,660, 5,861,254, 5,864,026, 5,869,641, 5,958,691, 6,001,988, 6,011,020, 6,013,443, 6,020,130, 6,028,186, 6,030,776, and 6,051,698.The term “synthetic aptamer” means an aptamer or aptameric sequence that is not heretofore known to occur in nature and function as a biological recognition site or an aptamer conjugate.", "Ribozymes are nucleic acid molecules that are capable of catalyzing a chemical reaction, either intramolecularly or intermolecularly.", "Ribozymes are, thus, catalytic nucleic acids.", "It is preferred that the ribozymes catalyze intermolecular reactions.", "There are a number of different types of ribozymes that catalyze nuclease or nucleic acid polymerase-type reactions, which are based on ribozymes found in natural systems, such as hammerhead ribozymes, (U.S. Pat.", "Nos.", "5,334,711, 5,436,330, 5,616,466, 5,633,133, 5,646,020, 5,652,094, 5,712,384, 5,770,715, 5,856,463, 5,861,288, 5,891,683, 5,891,684, 5,985,621, 5,989,908, 5,998,193, 5,998,203; International Patent Application Nos.", "WO 9858058 by Ludwig and Sproat, WO 9858057 by Ludwig and Sproat, and WO 9718312 by Ludwig and Sproat) hairpin ribozymes (for example, U.S. Pat.", "Nos.", "5,631,115, 5,646,031, 5,683,902, 5,712,384, 5,856,188, 5,866,701, 5,869,339, and 6,022,962), and tetrahymena ribozymes (for example, U.S. Pat.", "Nos.", "5,595,873 and 5,652,107).", "There are also a number of ribozymes that are not found in natural systems, but which have been engineered to catalyze specific reactions de novo (for example, U.S. Pat.", "Nos.", "5,580,967, 5,688,670, 5,807,718, and 5,910,408).", "Preferred ribozymes cleave RNA or DNA substrates and more preferably cleave RNA substrates.", "Ribozymes typically cleave nucleic acid substrates through recognition and binding of the target substrate with subsequent cleavage.", "This recognition is often based mostly on canonical or non-canonical base pair interactions.", "This property makes ribozymes particularly good candidates for target-specific cleavage of nucleic acids, because recognition of the target substrate is based on the target substrates sequence.", "Representative examples of how to make and use ribozymes to catalyze a variety of different reactions can be found in U.S. Pat.", "Nos.", "5,646,042, 5,693,535, 5,731,295, 5,811,300, 5,837,855, 5,869,253, 5,877,021, 5,877,022, 5,972,699, 5,972,704, 5,989,906, and 6,017,756.Triplex-forming functional nucleic acid molecules are molecules that can interact with either double-stranded or single-stranded nucleic acids.", "When triplex molecules interact with a target region, a structure called a triplex is formed, in which there are three strands of DNA forming a complex dependent on both Watson-Crick and Hoogsteen base-pairing.", "Triplex molecules are preferred because they can bind target regions with high affinity and specificity.", "It is preferred that the triplex-forming molecules bind the target molecule with a Kd less than 10−6, 10−8, 10−10, or 10−12.Representative examples of how to make and use triplex-forming molecules to bind a variety of different target molecules can be found in U.S. Pat.", "Nos.", "5,176,996; 5,645,985; 5,650,316; 5,683,874; 5,693,773; 5,834,185; 5,869,246; 5,874,566 and 5,962,426.External guide sequences (EGSs) are molecules that bind a target nucleic acid molecule forming a complex, and this complex is recognized by RNase P, which cleaves the target molecule.", "EGSs can be designed to specifically target a RNA molecule of choice.", "RNAse P aids in processing transfer RNA (tRNA) within a cell.", "Bacterial RNAse P can be recruited to cleave virtually any RNA sequence by using an EGS that causes the target RNA:EGS complex to mimic the natural tRNA substrate.", "(WO 92/03566 by Yale, and Forster and Altman, Science 238:407-409 (1990)).", "Similarly, eukaryotic EGS/RNAse P-directed cleavage of RNA can be utilized to cleave desired targets within eukarotic cells.", "(Yuan et al., Proc.", "Natl.", "Acad.", "Sci.", "USA 89:8006-8010 (1992); WO 93/22434 by Yale; WO 95/24489 by Yale; Yuan and Altman, EMBO J 14:159-168 (1995), and Carrara et al., Proc.", "Natl.", "Acad.", "Sci.", "(USA) 92:2627-2631 (1995)).", "Representative examples of how to make and use EGS molecules to facilitate cleavage of a variety of different target molecules be found in U.S. Pat.", "Nos.", "5,168,053, 5,624,824, 5,683,873, 5,728,521, 5,869,248, and 5,877,162.Gene expression can also be effectively silenced in a highly specific manner through RNA interference (RNAi).", "This silencing was originally observed with the addition of double-stranded RNA (dsRNA) (Fire, A., et al.", "(1998) Nature, 391:806-11; Napoli, C., et al.", "(1990) Plant Cell 2:279-89; Hannon, G. J.", "(2002) Nature, 418:244-51).", "Once dsRNA enters a cell, it is cleaved by an RNase III-like enzyme, Dicer, into double-stranded small interfering RNAs (siRNA) 21-23 nucleotides in length that contain 2 nucleotide overhangs on the 3′ ends (Elbashir, S. M., et al.", "(2001) Genes Dev., 15:188-200; Bernstein, E., et al.", "(2001) Nature, 409:363-6; Hammond, S. M., et al.", "(2000) Nature, 404:293-6).", "In an ATP-dependent step, the siRNAs become integrated into a multi-subunit protein complex, commonly known as the RNAi-induced silencing complex (RISC), which guides the siRNAs to the target RNA sequence (Nykanen, A., et al.", "(2001) Cell, 107:309-21).", "At some point, the siRNA duplex unwinds, and it appears that the antisense strand remains bound to RISC and directs degradation of the complementary mRNA sequence by a combination of endo and exonucleases (Martinez, J., et al.", "(2002) Cell, 110:563-74).", "However, the effect of iRNA or siRNA or their use is not limited to any type of mechanism.", "Short Interfering RNA (siRNA) is a double-stranded RNA that can induce sequence-specific post-transcriptional gene silencing, thereby decreasing or even inhibiting gene expression.", "In one example, an siRNA triggers the specific degradation of homologous RNA molecules, such as mRNAs, within the region of sequence identity between both the siRNA and the target RNA.", "For example, WO 02/44321 discloses siRNAs capable of sequence-specific degradation of target mRNAs when base-paired with 3′ overhanging ends, herein incorporated by reference for the method of making these siRNAs.", "Sequence-specific gene silencing can be achieved in mammalian cells using synthetic, short double-stranded RNAs that mimic the siRNAs produced by the enzyme Dicer (Elbashir, S. M., et al.", "(2001) Nature, 411:494 498) (Ui-Tei, K., et al.", "(2000) FEBS Lett 479:79-82).", "siRNA can be chemically or in vitro-synthesized or can be the result of short double-stranded hairpin-like RNAs (shRNAs) that are processed into siRNAs inside the cell.", "Synthetic siRNAs are generally designed using algorithms and a conventional DNA/RNA synthesizer.", "Suppliers include Ambion (Austin, Tex.", "), ChemGenes (Ashland, Mass.", "), Dharmacon (Lafayette, Colo.), Glen Research (Sterling, Va.), MWB Biotech (Esbersberg, Germany), Proligo (Boulder, Colo.), and Qiagen (Vento, The Netherlands).", "siRNA can also be synthesized in vitro using kits such as Ambion's SILENCER® siRNA Construction Kit.", "In certain examples, siRNAs are directed against certain target genes, such as the TL1A gene or the DR3 gene.", "The production of siRNA from a vector is more commonly done through the transcription of short hairpin RNAs (shRNAs).", "Kits for the production of vectors comprising shRNA are available, such as, for example, Imgenex's GENESUPPRESSOR™ Construction Kits and Invitrogen's BLOCK-IT™ inducible RNAi plasmid and lentivirus vectors.", "Disclosed herein are any shRNA designed as described above based on the sequences for the herein disclosed inflammatory mediators.", "Plasmids include antisense sequences that recognize one or more of the sequences shown in SEQ ID NOS:1 and 3 or a sequence that encodes a protein listed in SEQ ID NOS: 2 and 4.For example, cDNA fragments or variants coding for a host protein involved in viral infection are PCR amplified.", "The nucleotides are amplified using Pfu DNA polymerase (Stratagene) and cloned in antisense orientation in a vector, such as a pcDNA vector (InVitrogen, Carlsbad, Calif.).", "The nucleotide sequence and orientation of the insert can be confirmed by sequencing using a Sequenase kit (Amersham Pharmacia Biotech).", "ii.", "Dominant Negative Peptides The interaction between DR3 and TL1A can also be blocked using dominant negative mutants.", "For example, dominant negative mutants can consist of a truncated cytoplasmic domain of DR3 lacking the ‘death domain’ that recruits FADD, or point mutations in this region that abrogate FADD binding.", "Dominant negative constructs such as this have successfully blocked signaling by related receptors such as Fas.", "Likewise, dominant negative mutants of TL1A can be engineered to bind wild-type subunits of the TL1A trimer, but not bind ligand, as previously described (Steed et al., 2003).", "Another strategy for dominating inhibition could employ a pre-ligand assembly domain (PLAD) as described for TNFR1 and Fas in U.S. Pat.", "No.", "7,148,061, which is hereby incorporated herein by reference in its entirety for the teaching of PLADs.", "The PLAD for DR3 can comprise as few as 38 amino acids of the N-terminus of the mature DR3 receptor polypeptide.", "A mature receptor polypeptide does not include a signal sequence.", "Thus, a polypeptide having the sequence R1-PLAD-R2 is provided.", "Examples of PLADs of DR3 include those set forth in Table 1: TABLE 1 Pre-ligand assembly domain (PLAD) SEQ ID PLADs of DR3 NO: GARAQGGTRSPRCDCAGDFHKKIGLFCCRGCPAGHYLKAPCTEPCGNSTCLVCPQDTFLA 9 GARAQGGTRSPRCDCAGDFHKKIGLFCCRGCPAGHYLKAPCTEPCGNSTC 10 GARAQGGTRSPRCDCAGDFHKKIGLFCCRGCPAGHYLKAP 11 GARAQGGTRSPRCDCAGDFHKKIGLFCCRGCPAGHYLK 12 ..........PRCDCAGDFHKKIGLFCCRGCPAGHYLKAPCTEPCGNSTCLVCPQDTFLA 13 ....................KKIGLFCCRGCPAGHYLKAPCTEPCGNSTCLVCPQDTFLA 14 ......................IGLFCCRGCPAGHYLKAPCTEPCGNSTCLVCPQDTFLA 15 Disclosed is a polypeptide comprising R1-DR3 PLAD-R2, wherein R1 and R2 are optional and, when present, can be H, acyl, NH2, an amino acid, or a peptide.", "The DR3 PLAD can comprise amino acids 43-58 of SEQ ID NO:2.Thus, the DR3 PLAD can consist of amino acids 21-80, 22-80, 23-80, 24-80, 25-80, 26-80, 27-80, 28-80, 29-80, 30-80, 31-80, 32-80, 33-80, 34-80, 35-80, 36-80, 37-80, 38-80, 39-80, 40-80, 41-80, 42-80, 43-80 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-79, 22-79, 23-79, 24-79, 25-79, 26-79, 27-79, 28-79, 29-79, 30-79, 31-79, 32-79, 33-79, 34-79, 35-79, 36-79, 37-79, 38-79, 39-79, 40-79, 41-79, 42-79, 43-79 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-78, 22-78, 23-78, 24-78, 25-78, 26-78, 27-78, 28-78, 29-78, 30-78, 31-78, 32-78, 33-78, 34-78, 35-78, 36-78, 37-78, 38-78, 39-78, 40-78, 41-78, 42-78, 43-78 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-77, 22-77, 23-77, 24-77, 25-77, 26-77, 27-77, 28-77, 29-77, 30-77, 31-77, 32-77, 33-77, 34-77, 35-77, 36-77, 37-77, 38-77, 39-77, 40-77, 41-77, 42-77, 43-77 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-76, 22-76, 23-76, 24-76, 25-76, 26-76, 27-76, 28-76, 29-76, 30-76, 31-76, 32-76, 33-76, 34-76, 35-76, 36-76, 37-76, 38-76, 39-76, 40-76, 41-76, 42-76, 43-76 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-75, 22-75, 23-75, 24-75, 25-75, 26-75, 27-75, 28-75, 29-75, 30-75, 31-75, 32-75, 33-75, 34-75, 35-75, 36-75, 37-75, 38-75, 39-75, 40-75, 41-75, 42-75, 43-75 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-74, 22-74, 23-74, 24-74, 25-74, 26-74, 27-74, 28-74, 29-74, 30-74, 31-74, 32-74, 33-74, 34-74, 35-74, 36-74, 37-74, 38-74, 39-74, 40-74, 41-74, 42-74, 43-74 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-73, 22-73, 23-73, 24-73, 25-73, 26-73, 27-73, 28-73, 29-73, 30-73, 31-73, 32-73, 33-73, 34-73, 35-73, 36-73, 37-73, 38-73, 39-73, 40-73, 41-73, 42-73, 43-73 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-72, 22-72, 23-72, 24-72, 25-72, 26-72, 27-72, 28-72, 29-72, 30-72, 31-72, 32-72, 33-72, 34-72, 35-72, 36-72, 37-72, 38-72, 39-72, 40-72, 41-72, 42-72, 43-72 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-71, 22-71, 23-71, 24-71, 25-71, 26-71, 27-71, 28-71, 29-71, 30-71, 31-71, 32-71, 33-71, 34-71, 35-71, 36-71, 37-71, 38-71, 39-71, 40-71, 41-71, 42-71, 43-71 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-70, 22-70, 23-70, 24-70, 25-70, 26-70, 27-70, 28-70, 29-70, 30-70, 31-70, 32-70, 33-70, 34-70, 35-70, 36-70, 37-70, 38-70, 39-70, 40-70, 41-70, 42-70, 43-70 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-69, 22-69, 23-69, 24-69, 25-69, 26-69, 27-69, 28-69, 29-69, 30-69, 31-69, 32-69, 33-69, 34-69, 35-69, 36-69, 37-69, 38-69, 39-69, 40-69, 41-69, 42-69, 43-69 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-68, 22-68, 23-68, 24-68, 25-68, 26-68, 27-68, 28-68, 29-68, 30-68, 31-68, 32-68, 33-68, 34-68, 35-68, 36-68, 37-68, 38-68, 39-68, 40-68, 41-68, 42-68, 43-68 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-67, 22-67, 23-67, 24-67, 25-67, 26-67, 27-67, 28-67, 29-67, 30-67, 31-67, 32-67, 33-67, 34-67, 35-67, 36-67, 37-67, 38-67, 39-67, 40-67, 41-67, 42-67, 43-67 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-66, 22-66, 23-66, 24-66, 25-66, 26-66, 27-66, 28-66, 29-66, 30-66, 31-66, 32-66, 33-66, 34-66, 35-66, 36-66, 37-66, 38-66, 39-66, 40-66, 41-66, 42-66, 43-66 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-65, 22-65, 23-65, 24-65, 25-65, 26-65, 27-65, 28-65, 29-65, 30-65, 31-65, 32-65, 33-65, 34-65, 35-65, 36-65, 37-65, 38-65, 39-65, 40-65, 41-65, 42-65, 43-65 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-64, 22-64, 23-64, 24-64, 25-64, 26-64, 27-64, 28-64, 29-64, 30-64, 31-64, 32-64, 33-64, 34-64, 35-64, 36-64, 37-64, 38-64, 39-64, 40-64, 41-64, 42-64, 43-64 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-63, 22-63, 23-63, 24-63, 25-63, 26-63, 27-63, 28-63, 29-63, 30-63, 31-63, 32-63, 33-63, 34-63, 35-63, 36-63, 37-63, 38-63, 39-63, 40-63, 41-63, 42-63, 43-63 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-62, 22-62, 23-62, 24-62, 25-62, 26-62, 27-62, 28-62, 29-62, 30-62, 31-62, 32-62, 33-62, 34-62, 35-62, 36-62, 37-62, 38-62, 39-62, 40-62, 41-62, 42-62, 43-62 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-61, 22-61, 23-61, 24-61, 25-61, 26-61, 27-61, 28-61, 29-61, 30-61, 31-61, 32-61, 33-61, 34-61, 35-61, 36-61, 37-61, 38-61, 39-61, 40-61, 41-61, 42-61, 43-61 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-60, 22-60, 23-60, 24-60, 25-60, 26-60, 27-60, 28-60, 29-60, 30-60, 31-60, 32-60, 33-60, 34-60, 35-60, 36-60, 37-60, 38-60, 39-60, 40-60, 41-60, 42-60, 43-60 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-59, 22-59, 23-59, 24-59, 25-59, 26-59, 27-59, 28-59, 29-59, 30-59, 31-59, 32-59, 33-59, 34-59, 35-59, 36-59, 37-59, 38-59, 39-59, 40-59, 41-59, 42-59, 43-59 of SEQ ID NO:2.The DR3 PLAD can consist of amino acids 21-58, 22-58, 23-58, 24-58, 25-58, 26-58, 27-58, 28-58, 29-58, 30-58, 31-58, 32-58, 33-58, 34-58, 35-58, 36-58, 37-58, 38-58, 39-58, 40-58, 41-58, 42-58, 43-58 of SEQ ID NO:2.When R1 and/or R2 is a peptide, this peptide can vary in length.", "For example, R1 and/or R2 can be 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25 or more amino acids in length.", "The PLAD-containing polypeptide can be from 35-125 amino acids in length.", "In a further aspect, the entire polypeptide comprising the isolated TNF-like PLAD can be no more than 125 amino acid residues, and can, thus, be 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124 or 125 amino acids in length.", "R1 and R2 can be sequences that do not normally flank the DR3 PLAD in a naturally occurring DR3 receptor.", "R1 and R2 can also be sequences of the DR3 receptor that normally flank the DR3 PLAD in a naturally occurring TNF receptor-like receptor, wherein the polypeptide comprising the TNF-like receptor PLAD is not the entire extracellular domain of a TNF receptor-like receptor.", "iii.", "DR3 Fusion Protein The interaction between DR3 and TL1A can also be blocked using a DR3 Fc fusion protein.", "Thus, provided is a composition comprising a DR3 Fc fusion protein.", "A fusion protein comprising or consisting of the DR3 extracellular domain (about 140-150 aa) fused to a non-Fc receptor binding mutant of human IgG1 (IgG Fc (DR3 (human)-huIg Fusion Protein)) is provided.", "The fusion protein can be expressed in eukaryotic cells and purified using protein A for use in vitro and in vivo.", "Alternatively, the cDNA encoding the fusion protein is expressed through hydrodynamic injection into the tail vein of mice.", "This technique can produce high-level expression of the DR3Fc protein during or after induction of autoimmune disease models.", "(Dagnaes-Hansen et al., 2002; Hodges and Scheule, 2003; Lecocq et al., 2003) The nucleic acids encoding a polypeptide comprising or consisting of a DR3 region can also be functionally linked to other nucleic acids to encode an immunoadhesin.", "For the purposes of the present disclosure, the term “immunoadhesin” is defined as including any polypeptide encoded by a nucleic acid, where at least a portion of a nucleic acid encoding a non-immunoglobulin molecule such as a DR3 extracellular domain is coupled to at least a portion of a nucleic acid encoding an immunoglobulin heavy chain polypeptide, IgG, for example.", "The Fc regions of IgG2, IgG3, IgM, IgA, IgE can also be utilized to construct an immunoadhesin.", "The coupling may be achieved in a manner which provides for a functional transcribing and translating of the nucleic acid segment and message derived therefrom, respectively.", "These IgG immunoadhesins can be expressed by transient or stable transfection in a variety of mammalian host cells, as well as in baculovirus-infected cells.", "Similar to antibodies, IgG immunoadhesins can be purified from the culture medium into which they are secreted by single-step protein A or protein G affinity chromatography.", "iv.", "Antibodies The interaction between DR3 and TL1A can be blocked by administration of anti-DR3 antibodies.", "To block the interaction, the anti-DR3 antibody must be antagonistic.", "Additionally, a DR3 Fc fusion protein can inhibit the interaction between DR3 and TL1A.", "The interaction between DR3 and TL1A can be blocked by administration of anti-TL1A antibodies.", "Blocking antibodies against TL1A and DR3 are generated by immunizing mice with the fully glycosylated mammalian extracellular domains of these proteins and specifically screening for blocking activity in a bioassay for TL1A-DR3 binding and signal transduction.", "Thus, provided is an anti-TL1A antibody that specifically binds surface TL1A and interferes with TL1A-induced cell death of an indicator cell line.", "For example, FIG.", "20 shows the characterization of functional anti-TL1A blocking antibodies.", "These antibodies inhibited TL1A-induced apoptosis (FIG.", "20E).", "v. Diseases In the disclosed methods of treating inflammatory or autoimmune disease, the inflammatory or autoimmune disease can be an autoimmune disease with a T cell component.", "In the disclosed methods of treating inflammatory or autoimmune disease, the inflammatory or autoimmune disease is asthma.", "The present data show that DR3 knock-out mice are resistant to an animal model of asthma, suggesting that blockade of TL1A/DR3 interactions would be effective in this model and human asthma.", "In the disclosed methods of treating inflammatory or autoimmune disease, the inflammatory or autoimmune disease can be multiple sclerosis.", "There is abundant evidence to support the role of activated T cells in MS: extravasation of activated T cells into the brain, spinal cord and CSF of MS patients, production of inflammatory cytokines such as IL-17 and interferon gamma by T cells in MS and experimental MS animal model lesions.", "DR3 is expressed on activated T cells and deficiency of DR3 impairs inflammatory cytokine production by activated T cells as shown herein.", "Therefore, blockade of DR3-TL1A interactions is expected to impair T cell cytokine production and ameliorate MS.", "In the disclosed methods of treating inflammatory or autoimmune disease, the inflammatory or autoimmune disease can be rheumatoid arthritis.", "Activated T cells can be found in the synovium of patients with rheumatoid arthritis, and agents that block T cell function are efficacious in this disease, for example, costimulatory T cell blockade by CTLA4.DR3 is expressed on activated T cells, and deficiency of DR3 impairs inflammatory cytokine production by activated T cells as shown herein.", "Therefore, blockade of DR3-TL1A interactions is expected to impair T cell cytokine production and ameliorate RA.", "In the disclosed methods of treating inflammatory or autoimmune disease, the inflammatory or autoimmune disease can be type 1 diabetes.", "Type I diabetes is caused by activated T cells which infiltrate the pancreas and destroy the islets of langerhans.", "DR3 is expressed on activated T cells, and deficiency of DR3 impairs inflammatory cytokine production by activated T cells.", "Therefore, blockade of DR3-TL1A interactions is expected to impair T cell cytokine production and ameliorate type I diabetes.", "In the disclosed methods of treating inflammatory or autoimmune disease, the inflammatory or autoimmune disease can be graft versus host disease.", "Allospecific activated T cells which express DR3 secrete cytokines and effector molecules that are critical for graft vs. host disease.", "Blockade of the TNF family members TL1A, Light, and FasL through administration of a soluble decoy receptor DcR3/TR6 that binds all three ligands did downmodulate graft vs. host disease in a mouse model (Zhang et al., 2001).", "Because deficiency of DR3 impairs inflammatory cytokine production by activated T cells, blockade of DR3/TL1A interactions by the above-disclosed methods is expected to treat or prevent graft vs. host disease.", "In some aspects of the disclosed methods of treating inflammatory or autoimmune disease, the inflammatory or autoimmune disease is inflammatory bowel disease (IBD).", "Thus, in some aspects, the inflammatory or autoimmune disease of the method is Crohn's disease.", "TL1A and DR3 have been found to be expressed in tissue samples from patients with inflammatory bowel disease and mouse models of IBD (Bamias et al., 2003; Bamias et al., 2006).", "In addition, multiple lines of transgenic mice expressing TL1A constitutively in T cells or dendritic cells develop spontaneous inflammatory bowel disease centered in the duodenum and ileum characterized histologically by destruction of villi, bowel wall thickening, and inflammatory cell infiltrates.", "Thus, blockade of DR3/TL1A interactions by the above-disclosed methods is expected to treat or prevent IBD.", "In other aspects, the inflammatory or autoimmune disease of the method is not inflammatory bowel disease (IBD).", "Thus, in some aspects, the inflammatory or autoimmune disease of the method is not Crohn's desease.", "2.Verification of Efficacy Also provided are methods for verifying the efficacy of the compositions and methods for treating inflammatory or autoimmune diseases.", "Animals can be induced to exhibit relevant characteristics of inflammatory bowel disease and colitis.", "The animal in which the colitis is produced can be any mammal and can include, but is not limited to, mouse, rat, guinea pig, hamster, rabbit, cat, dog, goat, monkey, and chimpanzee.", "The colitis can be produced in the animal by any method known in the art.", "For example, the colitis can be produced by introducing into the colon of the animal an effective amount of a hapten reagent.", "As an example, the hapten reagent can be trinitrobenzene sulfonic acid (TNBS) or oxazolone (4-ethoxymethylene-2-phenyl-2-oxazolin-5-one).", "Th1-mediated colitis can be induced in mice using TNBS.", "Acute TNBS-colitis can be induced in SJL or C57BL10 mice using a single dose of TNBS.", "Briefly, 2.5 mg of TNBS (pH 1.5-2.0; Sigma Aldrich, St Louis, Mo.)", "in 50% ethanol is administered intrarectally in a total volume of 150 μl to lightly anesthetized mice.", "To establish a chronic model of TNBS colitis, Balb/c mice are administered weekly dosages of TNBS per rectum in the following manner.", "Mice are administered 1.5 mg of TNBS (delivered in a 50% ethanol vehicle in a total volume of 150 μl) for weeks 1-2, 2.0 mg of TNBS for weeks 3-4, and 2.5 mg of TNBS for weeks 5-6.Th2-mediated colitis can be induced in mice with oxazolone.", "Briefly, mice are presensitized by painting the skin with 0.2 mL 3% oxazolone in 100% ethanol; 5 days after presensitization, mice are challenged intra-rectally with 150 μl 1% oxazolone in 50% ethanol under general anesthesia with isoflurane (Baxter, Deerfield, Ill.).", "These models can be used to test the anti-DR3 and anti-TL1A antibodies and the DR3-Fc fusion protein disclosed herein.", "3.Screening Assay Also provided herein is a method of identifying an agent that can be used to treat an inflammatory disease.", "The method can comprise providing a sample comprising DR3 and TL1A under conditions that allow the binding of DR3 and TL1A, contacting the sample with a candidate agent, detecting the level of DR3/TL1A binding, comparing the binding level to a control, a decrease in DR3/TL1A binding compared to the control identifying an agent that can be used to treat an inflammatory disease.", "The binding of DR3 to TL1A can be detected using routine methods, such as immunodetection methods, that do not disturb protein binding.", "The methods can be cell-based or cell-free assays.", "The steps of various useful immunodetection methods have been described in the scientific literature, such as, e.g., Maggio et al., Enzyme-Immunoassay, (1987) and Nakamura, et al., Enzyme Immunoassays: Heterogeneous and Homogeneous Systems, Handbook of Experimental Immunology, Vol.", "1: Immunochemistry, 27.1-27.20 (1986), each of which is incorporated herein by reference in its entirety and specifically for its teaching regarding immunodetection methods.", "Immunoassays, in their most simple and direct sense, are binding assays involving binding between antibodies and antigen.", "Many types and formats of immunoassays are known, and all are suitable for detecting the disclosed biomarkers.", "Examples of immunoassays are enzyme-linked immunosorbent assays (ELISAs), radioimmunoassays (RIA), radioimmune precipitation assays (RIPA), immunobead capture assays, Western blotting, dot blotting, gel-shift assays, flow cytometry, protein arrays, multiplexed bead arrays, magnetic capture, in vivo imaging, fluorescence resonance energy transfer (FRET), and fluorescence recovery/localization after photobleaching (FRAP/FLAP).", "The binding of DR3 to TL1A can be detected using fluorescence activated cell sorting (FACS).", "For example, disclosed are cell lines transfected with TL1A and DR3 fused to fluorescent proteins.", "These cell lines can facilitate high-throughput screens for biologically expressed and small molecule binding to TL1A and DR3 in their physiological forms.", "In general, candidate agents can be identified from large libraries of natural products or synthetic (or semi-synthetic) extracts or chemical libraries according to methods known in the art.", "Those skilled in the field of drug discovery and development will understand that the precise source of test extracts or compounds is not critical to the screening procedure(s) of the invention.", "Accordingly, virtually any number of chemical extracts or compounds can be screened using the exemplary methods described herein.", "Examples of such extracts or compounds include, but are not limited to, plant-, fungal-, prokaryotic-, or animal-based extracts, fermentation broths, and synthetic compounds, as well as modifications of existing compounds.", "Numerous methods are also available for generating random or directed synthesis (e.g., semi-synthesis or total synthesis) of any number of chemical compounds, including, but not limited to, saccharide-, lipid-, peptide-, polypeptide-, and nucleic acid-based compounds.", "Synthetic compound libraries are commercially available, e.g., from Brandon Associates (Merrimack, N.H.) and Aldrich Chemical (Milwaukee, Wis.).", "Alternatively, libraries of natural compounds in the form of bacterial, fungal, plant, and animal extracts are commercially available from a number of sources, including Biotics (Sussex, UK), Xenova (Slough, UK), Harbor Branch Oceangraphics Institute (Ft. Pierce, Fla.), and PharmaMar, U.S.A. (Cambridge, Mass.).", "In addition, natural and synthetically produced libraries are produced, if desired, according to methods known in the art, e.g., by standard extraction and fractionation methods.", "Furthermore, if desired, any library or compound is readily modified using standard chemical, physical, or biochemical methods.", "In addition, those skilled in the art of drug discovery and development readily understand that methods for dereplication (e.g., taxonomic dereplication, biological dereplication, and chemical dereplication, or any combination thereof) or the elimination of replicates or repeats of materials already known for their effect on the activity of reducing inflammation should be employed whenever possible.", "When a crude extract is found to have a desired activity, further fractionation of the positive lead extract is necessary to isolate chemical constituents responsible for the observed effect.", "Thus, the goal of the extraction, fractionation, and purification process is the careful characterization and identification of a chemical entity within the crude extract having an activity that stimulates or inhibits the binding of DR3 and TL1A.", "The same assays described herein for the detection of activities in mixtures of compounds can be used to purify the active component and to test derivatives thereof.", "Methods of fractionation and purification of such heterogenous extracts are known in the art.", "If desired, compounds shown to be useful agents for treatment are chemically modified according to methods known in the art.", "Compounds identified as being of therapeutic value may be subsequently analyzed using animal models for diseases or conditions, such as those disclosed herein.", "Candidate agents encompass numerous chemical classes, but are most often organic molecules, e.g., small organic compounds having a molecular weight of more than 100 and less than about 2,500 daltons.", "Candidate agents comprise functional groups necessary for structural interaction with proteins, particularly hydrogen bonding, and typically include at least an amine, carbonyl, hydroxyl, or carboxyl group, for example, at least two of the functional chemical groups.", "The candidate agents often comprise cyclical carbon or heterocyclic structures and/or aromatic or polyaromatic structures substituted with one or more of the above functional groups.", "Candidate agents are also found among biomolecules including peptides, saccharides, fatty acids, steroids, purines, pyrimidines, derivatives, structural analogs, or combinations thereof.", "In a further embodiment, candidate agents are peptides.", "In some embodiments, the candidate agents are proteins.", "In some aspects, the candidate agents are naturally occurring proteins or fragments of naturally occurring proteins.", "Thus, for example, cellular extracts containing proteins, or random or directed digests of proteinaceous cellular extracts, can be used.", "In this way, libraries of prokaryotic and eukaryotic proteins can be made for screening using the methods herein.", "The libraries can be bacterial, fungal, viral, vertebrate proteins, and human proteins.", "4.Administration Administration means a method of administering to a subject.", "Such methods are well known to those skilled in the art and include, but are not limited to: administration topically, parenterally, orally, intravenously, intramuscularly, subcutaneously, or by aerosol.", "Administration may be effected continuously or intermittently.", "For in vivo administration, the pharmaceutical compositions are preferably administered parenterally, i.e., intravenously, intraperitoneally, subcutaneously, intrathecally, injection to the spinal cord, intramuscularly, intraarticularly, portal vein injection, or intratumorally.", "The term “parenteral,” as used herein, refers to modes of administration, which include intravenous, intramuscular, intraperitoneal, intrasternal, subcutaneous and intraarticular injection, and infusion.", "Pharmaceutical compositions for parenteral injection comprise pharmaceutically acceptable sterile aqueous or non-aqueous solutions, dispersions, suspensions, or emulsions, as well as sterile powders for reconstitution into sterile injectable solutions or dispersions just prior to use.", "Examples of suitable aqueous and non-aqueous carriers, diluents, solvents, or vehicles include water, ethanol, polyols (such as glycerol, propylene glycol, polyethylene glycol, and the like), carboxymethylcellulose and suitable mixtures thereof, vegetable oils (such as olive oil), and injectable organic esters such as ethyl oleate.", "Proper fluidity may be maintained, for example, by the use of coating materials such as lecithin, by the maintenance of the required particle size in the case of dispersions, and by the use of surfactants.", "These compositions may also contain preservatives, wetting agents, emulsifying agents, and dispersing agents.", "Prevention of the action of microorganisms may be ensured by the inclusion of various antibacterial and antifungal agents such as paraben, chlorobutanol, phenol sorbic acid, and the like.", "It may also be desirable to include isotonic agents such as sugars, sodium chloride, and the like.", "Prolonged absorption of the injectable pharmaceutical form may be brought about by the inclusion of agents, such as aluminum monostearate and gelatin, which delay absorption.", "Injectable depot forms are made by forming microencapsule matrices of the drug in biodegradable polymers such as polylactide-polyglycolide, poly(orthoesters), and poly(anhydrides).", "Depending upon the ratio of drug to polymer and the nature of the particular polymer employed, the rate of drug release can be controlled.", "Depot injectable formulations are also prepared by entrapping the drug in liposomes or microemulsions, which are compatible with body tissues.", "The injectable formulations may be sterilized, for example, by filtration through a bacterial-retaining filter or by incorporating sterilizing agents in the form of sterile solid compositions, which can be dissolved or dispersed in sterile water or other sterile injectable media just prior to use.", "In other methods, the pharmaceutical preparations may be contacted with the target tissue by direct application of the preparation to the tissue.", "The application may be made by topical, “open”, or “closed” procedures.", "By “topical”, it is meant the direct application of the pharmaceutical preparation to a tissue exposed to the environment, such as the skin, nasopharynx, external auditory canal, eye, inhalation to the lung, genital mucosa, and the like.", "“Open” procedures are those procedures which include incising the skin of a patient and directly visualizing the underlying tissue to which the pharmaceutical preparations are applied.", "This is generally accomplished by a surgical procedure, such as a thoracotomy to access the lungs, abdominal laparotomy to access abdominal viscera, or other direct surgical approach to the target tissue.", "“Closed” procedures are invasive procedures in which the internal target tissues are not directly visualized, but accessed via inserting instruments through small wounds in the skin.", "For example, the preparations may be administered to the peritoneum by needle lavage.", "Likewise, the pharmaceutical preparations may be administered to the meninges or spinal cord by infusion during a lumbar puncture followed by appropriate positioning of the patient as commonly practiced for spinal anesthesia or metrazamide imaging of the spinal cord.", "Alternatively, the preparations may be administered through endoscopic devices.", "Topical administration includes administration to the skin, mucosa, and surfaces of the lung and eye.", "Compositions for topical administration, including those for inhalation, may be prepared as a dry powder, which may be pressurized or non-pressurized.", "In non-pressurized powder compositions, the active ingredient in finely divided form may be used in admixture with a larger-sized pharmaceutically acceptable inert carrier comprising particles having a size, for example, of up to 100 micrometers in diameter.", "For topical administration to the eye, a compound of the invention is delivered in a pharmaceutically acceptable ophthalmic vehicle, such that the compound is maintained in contact with the ocular surface for a sufficient time period to allow the compound to penetrate the corneal and internal regions of the eye, as, for example, the anterior chamber, posterior chamber, vitreous body, aqueous humor, vitreous humor, cornea, iris/cilary, lens, choroid/retina, and sclera.", "The pharmaceutically acceptable ophthalmic vehicle may, for example, be an ointment, vegetable oil, or an encapsulating material.", "Alternatively, a compound of the invention may be injected directly into the vitrious and aqueous humor.", "Compositions for rectal or vaginal administration are preferably suppositories, which may be prepared by mixing the compounds of this invention with suitable non-irritating excipients or carriers such as cocoa butter, polyethylene glycol, or a suppository wax, which are solids at room temperature but liquids at body temperature and, therefore, melt in the rectum or vaginal cavity and release the active compound.", "Dosage range to have effect on symptoms but to avoid adverse side affects; doses will vary with age, sex, condition, extent of disease.", "When used in the above or other treatments, a therapeutically effective amount of one of the compounds of the present invention may be employed in pure form or, where such forms exist, in pharmaceutically acceptable salt form and with or without a pharmaceutically acceptable excipient.", "The specific therapeutically effective dose level for any particular patient will depend upon a variety of factors including the disorder being treated and the severity of the disorder; activity of the specific compound employed; the specific composition employed; the age, body weight, general health, sex, and diet of the patient; the time of administration; the route of administration; the rate of excretion of the specific compound employed; the duration of the treatment; drugs used in combination or coincidential with the specific compound employed and like factors well known in the medical arts.", "For example, it is well within the skill of the art to start doses of the compound at levels lower than those required to achieve the desired therapeutic effect and to gradually increase the dosage until the desired effect is achieved.", "If desired, the effective daily dose may be divided into multiple doses for purposes of administration.", "Consequently, single dose compositions may contain such amounts or submultiples thereof to make up the daily dose.", "The dosage can be adjusted by the individual physician in the event of any counterindications.", "Dosage can vary, and can be administered in one or more dose administrations daily, for one or several days.", "Guidance can be found in the literature for appropriate dosages for given classes of pharmaceutical products.", "For example, guidance in selecting appropriate doses for antibodies can be found in the literature on therapeutic uses of antibodies, e.g., Handbook of Monoclonal Antibodies, Ferrone et al., eds., Noges Publications, Park Ridge, N.J., (1985) ch.", "22 and pp.", "303-357; Smith et al., Antibodies in Human Diagnosis and Therapy, Haber et al., eds., Raven Press, New York (1977) pp.", "365-389.Based on experience with other Fc fusion proteins and blocking antibodies against other TNF family members, a typical daily dosage of the FcFusion protein used range from about 0.5 to about 10 mg/kg of body weight or more per day, depending on the factors mentioned above.", "Monoclonal antibodies are given subcutaneously at about 1 to about 5 mg/kg body weight either as an IV infusion or subcutaneously.", "For example, a typical daily dosage of the disclosed composition used alone might range from about 1 μg/kg to up to 100 mg/kg of body weight or more per day, depending on the factors mentioned above.", "Following administration of a disclosed composition for treating, inhibiting, or preventing an immunopathology, the efficacy of the therapeutic can be assessed in various ways well known to the skilled practitioner.", "For instance, one of ordinary skill in the art will understand that a composition disclosed herein is efficacious in treating or inhibiting an immunopathologyin a subject by observing that the composition reduces or prevents a further increase in immunopathology.", "Immunopathologycan be measured by methods that are known in the art.", "The compositions that inhibit DR3 and TL1A interactions disclosed herein may be administered prophylactically to patients or subjects who are at risk for immunopathology or who have been newly diagnosed with immunopathology.", "The disclosed compositions and methods can also be used, for example, as tools to isolate and test new drug candidates for a variety of immunopathology-related diseases.", "i.", "Administration of Proteins The protein may be formulated for the purpose of administration topically, orally, parenterally, intranasally, intravenously, intramuscularly, subcutaneously, intraocularly, transdermally and the like.", "Doses of such therapeutic protein agents are well known to those of skill in the art and may be found in pharmaceutical compedia such as the PHYSICIANS DESK REFERENCE, Medical Economics Data Publishers; REMINGTON'S PHARMACEUTICAL SCIENCES, Mack Publishing Co.; GOODMAN & GILMAN, THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, McGraw Hill Publ., THE CHEMOTHERAPY SOURCE BOOK, Williams and Wilkens Publishers, and may, alternatively, routinely be determined using standard techniques well known to those of skill in the art, such as, for example, are described, below, at the end of this Section.", "ii.", "Administration of Antibodies Administration of the antibodies can be done as disclosed herein.", "Nucleic acid approaches for antibody delivery also exist.", "The broadly blocking anti-DR3 or TL1A antibodies and antibody fragments can also be administered to patients or subjects as a nucleic acid preparation (e.g., DNA or RNA) that encodes the antibody or antibody fragment, such that the patient's or subject's own cells take up the nucleic acid and produce and secrete the encoded antibody or antibody fragment.", "Antibodies of the invention are preferably administered to a subject in a pharmaceutically acceptable carrier.", "Suitable carriers and their formulations are described in Remington: The Science and Practice of Pharmacy (19th ed.)", "ed.", "A. R. Gennaro, Mack Publishing Company, Easton, Pa. 1995.Typically, an appropriate amount of a pharmaceutically acceptable salt is used in the formulation to render the formulation isotonic.", "Examples of the pharmaceutically acceptable carrier include, but are not limited to, saline, Ringer's solution, and dextrose solution.", "The pH of the solution is preferably from about 5 to about 8, and more preferably from about 7 to about 7.5.Further carriers include sustained release preparations such as semipermeable matrices of solid hydrophobic polymers containing the antibody, which matrices are in the form of shaped articles, e.g., films, liposomes, or microparticles.", "It will be apparent to those persons skilled in the art that certain carriers may be more preferable depending upon, for instance, the route of administration and concentration of antibody being administered.", "The antibodies can be administered to the subject, patient, or cell by injection (e.g., intravenous, intraperitoneal, subcutaneous, intramuscular) or by other methods such as infusion that ensure its delivery to the bloodstream in an effective form.", "Local or intravenous injection is preferred.", "Effective dosages and schedules for administering the antibodies may be determined empirically, and making such determinations is within the skill in the art.", "Those skilled in the art will understand that the dosage of antibodies that must be administered will vary depending on, for example, the subject that will receive the antibody, the route of administration, the particular type of antibody used, and other drugs being administered.", "Guidance in selecting appropriate doses for antibodies is found in the literature on therapeutic uses of antibodies, e.g., Handbook of Monoclonal Antibodies, Ferrone et al., eds., Noges Publications, Park Ridge, N.J., (1985) ch.", "22 and pp.", "303-357; Smith et al., Antibodies in Human Diagnosis and Therapy, Haber et al., eds., Raven Press, New York (1977) pp.", "365-389.A typical daily dosage of the antibody used alone might range from about 1 μg/kg to up to 100 mg/kg of body weight or more per day, depending on the factors mentioned above.", "iii.", "Administration of Nucleic Acids In the methods described above, which include the administration and uptake of exogenous nucleic acids into the cells of a subject (i.e., gene transduction or transfection), the disclosed nucleic acids can be in the form of naked DNA or RNA, or the nucleic acids can be in a vector for delivering the nucleic acids to the cells, whereby the antibody-encoding DNA fragment is under the transcriptional regulation of a promoter, as would be well understood by one of ordinary skill in the art.", "The vector can be a commercially available preparation, such as an adenovirus vector (Quantum Biotechnologies, Inc. (Laval, Quebec, Canada)).", "Delivery of the nucleic acid or vector to cells can be via a variety of mechanisms.", "As one example, delivery can be via a liposome, using commercially available liposome preparations such as LIPOFECTIN, LIPOFECTAMINE (GIBCO-BRL, Inc., Gaithersburg, Md.", "), SUPERFECT (Qiagen, Inc. Hilden, Germany) and TRANSFECTAM (Promega Biotec, Inc., Madison, Wis.), as well as other liposomes developed according to procedures standard in the art.", "In addition, the disclosed nucleic acid or vector can be delivered in vivo by electroporation, the technology for which is available from Genetronics, Inc. (San Diego, Calif.), as well as by means of a SONOPORATION machine (ImaRx Pharmaceutical Corp., Tucson, Ariz.).", "As one example, vector delivery can be via a viral system, such as a retroviral vector system, which can package a recombinant retroviral genome (see e.g., Pastan et al., Proc.", "Natl.", "Acad.", "Sci.", "U.S.A. 85:4486, 1988; Miller et al., Mol.", "Cell.", "Biol.", "6:2895, 1986).", "The recombinant retrovirus can then be used to infect and thereby deliver to the infected cells nucleic acid encoding a blocking antibody (or active fragment thereof).", "The exact method of introducing the altered nucleic acid into mammalian cells is, of course, not limited to the use of retroviral vectors.", "Other techniques are widely available for this procedure including the use of adenoviral vectors (Mitani et al., Hum.", "Gene Ther.", "5:941-948, 1994), adeno-associated viral (AAV) vectors (Goodman et al., Blood 84:1492-1500, 1994), lentiviral vectors (Naidini et al., Science 272:263-267, 1996), pseudotyped retroviral vectors (Agrawal et al., Exper.", "Hematol.", "24:738-747, 1996).", "Physical transduction techniques can also be used, such as liposome delivery and receptor-mediated and other endocytosis mechanisms (see, for example, Schwartzenberger et al., Blood 87:472-478, 1996).", "The disclosed compositions and methods can be used in conjunction with any of these or other commonly used gene transfer methods.", "As one example, if the antibody-encoding nucleic acid is delivered to the cells of a subject in an adenovirus vector, the dosage for administration of adenovirus to humans can range from about 107 to 109 plaque-forming units (pfu) per injection but can be as high as 1012 pfu per injection (Crystal, Hum.", "Gene Ther.", "8:985-1001, 1997; Alvarez and Curiel, Hum.", "Gene Ther.", "8:597-613, 1997).", "A subject can receive a single injection, or, if additional injections are necessary, they can be repeated at six-month intervals (or other appropriate time intervals, as determined by the skilled practitioner) for an indefinite period and/or until the efficacy of the treatment has been established.", "B. Compositions 1.Antibodies Provided is an antibody that has the binding characteristics of an antibody that binds the TL1A or DR3 polypeptide and blocks the binding of TL1A to DR3.Thus, provided is an antibody that has the binding characteristics of an antibody that binds the TL1A polypeptide comprising SEQ ID NO:4, or a fragment thereof that binds DR3.Also provided is an antibody that has the binding characteristics of an antibody that binds the extracellular domain of TL1A polypeptide.", "Thus, provided is an antibody that has the binding characteristics of an antibody that binds the TL1A polypeptide comprising amino acids 76-252 of SEQ ID NO: 4, or a fragment thereof that binds DR3.Thus, provided is an antibody that has the binding characteristics of an antibody that binds the TL1A polypeptide comprising amino acids 76-252, 77-252, 78-252, 76-252, 79-252, 80 252, 81-252, 82-252, 83-252, 84-252, 85-252, 86-252, 87-252, 88-252, 89-252, 90-252, 91-252, 92-252, 93-252, 94-252, 95-252, 96-252, 97-252, 98-252, 99-252, or 100-252 of SEQ ID NO:4.Thus, provided is an antibody that has the binding characteristics of an antibody that binds the TL1A polypeptide comprising amino acids 76-251, 77-251, 78-251, 76-251, 79-251, 80-251, 81-251, 82-251, 83-251, 84-251, 85-251, 86-251, 87-251, 88-251, 89-251, 90-251, 91-251, 92-251, 93-251, 94-251, 95-251, 96-251, 97-251, 98-251, 99-251, or 100-251 of SEQ ID NO:4.Thus, provided is an antibody that has the binding characteristics of an antibody that binds the TL1A polypeptide comprising amino acids 76-250, 77-250, 78-250, 76-250, 79-250, 80-250, 81-250, 82-250, 83-250, 84-250, 85-250, 86-250, 87-250, 88-250, 89-250, 90-250, 91-250, 92-250, 93-250, 94-250, 95-250, 96-250, 97-250, 98-250, 99-250, or 100-250 of SEQ ID NO:4.Thus, provided is an antibody that has the binding characteristics of an antibody that binds the TL1A polypeptide comprising amino acids 76-249, 77-249, 78-249, 76-249, 79-249, 80-249, 81-249, 82-249, 83-249, 84-249, 85-249, 86-249, 87-249, 88-249, 89-249, 90-249, 91-249, 92-249, 93-249, 94-249, 95-249, 96-249, 97-249, 98-249, 99-249, or 100-249 of SEQ ID NO:4.Thus, provided is an antibody that has the binding characteristics of an antibody that binds the TLIA polypeptide comprising amino acids 76-248, 77-248, 78-248, 76-248, 79-248, 80-248, 81-248, 82-248, 83-248, 84-248, 85-248, 86-248, 87-248, 88-248, 89-248, 90-248, 91-248, 92-248, 93-248, 94-248, 95-248, 96-248, 97-248, 98-248, 99-248, or 100-248 of SEQ ID NO:4.Thus, provided is an antibody that has the binding characteristics of an antibody that binds the TL1A polypeptide comprising amino acids 76-247, 77-247, 78-247, 76-247, 79-247, 80-247, 81-247, 82-247, 83-247, 84-247, 85-247, 86-247, 87-247, 88-247, 89-247, 90-247, 91-247, 92-247, 93-247, 94-247, 95-247, 96-247, 97-247, 98-247, 99-247, or 100-247 of SEQ ID NO:4.Thus, provided is an antibody that has the binding characteristics of an antibody that binds the TL1A polypeptide comprising amino acids 76-246, 77-246, 78-246, 76-246, 79-246, 80-246, 81-246, 82-246, 83-246, 84-246, 85-246, 86-246, 87-246, 88-246, 89-246, 90-246, 91-246, 92-246, 93-246, 94-246, 95-246, 96-246, 97-246, 98-246, 99-246, or 100-246 of SEQ ID NO:4.Thus, provided is an antibody that has the binding characteristics of an antibody that binds the TL1A polypeptide comprising amino acids 76-245, 77-245, 78-245, 76-245, 79-245, 80-245, 81-245, 82-245, 83-245, 84-245, 85-245, 86-245, 87-245, 88-245, 89-245, 90-245, 91-245, 92-245, 93-245, 94-245, 95-245, 96-245, 97-245, 98-245, 99-245, or 100-245 of SEQ ID NO:4.Thus, provided is an antibody that has the binding characteristics of an antibody that binds the TL1A polypeptide comprising amino acids 76-240, 77-240, 78-240, 76-240, 79-240, 80-240, 81-240, 82-240, 83-240, 84-240, 85-240, 86-240, 87-240, 88-240, 89-240, 90-240, 91-240, 92-240, 93-240, 94-240, 95-240, 96-240, 97-240, 98-240, 99-240, or 100-240 of SEQ ID NO:4.Thus, provided is an antibody that has the binding characteristics of an antibody that binds the TL1A polypeptide comprising amino acids 76-230, 77-230, 78-230, 76-230, 79-230, 80-230, 81-230, 82-230, 83-230, 84-230, 85-230, 86-230, 87-230, 88-230, 89-230, 90-230, 91-230, 92-230, 93-230, 94-230, 95-230, 96-230, 97-230, 98-230, 99-230, or 100-230 of SEQ ID NO:4.Thus, provided is an antibody that has the binding characteristics of an antibody that binds the TL1A polypeptide comprising amino acids 76-220, 77-220, 78-220, 76-220, 79-220, 80-220, 81-220, 82-220, 83-220, 84-220, 85-220, 86-220, 87-220, 88-220, 89-220, 90-220, 91-220, 92-220, 93-220, 94-220, 95-220, 96-220, 97-220, 98-220, 99-220, or 100-220 of SEQ ID NO:4.Thus, provided is an antibody that has the binding characteristics of an antibody that binds the TL1A polypeptide comprising amino acids 76-210, 77-210, 78-210, 76-210, 79-210, 80-210, 81-210, 82-210, 83-210, 84-210, 85-210, 86-210, 87-210, 88-210, 89-210, 90-210, 91-210, 92-210, 93-210, 94-210, 95-210, 96-210, 97-210, 98-210, 99-210, or 100-210 of SEQ ID NO:4.Thus, provided is an antibody that has the binding characteristics of an antibody that binds the TL1A polypeptide comprising amino acids 76-200, 77-200, 78-200, 76-200, 79-200, 80-200, 81-200, 82-200, 83-200, 84-200, 85-200, 86-200, 87-200, 88-200, 89-200, 90-200, 91-200, 92-200, 93-200, 94-200, 95-200, 96-200, 97-200, 98-200, 99-200, or 100-200 of SEQ ID NO:4.Thus, provided is an antibody that has the binding characteristics of an antibody produced by the hybridoma clones designated 1A9 and 106 that bind the human TL1A polypeptide and Hybridoma clones designated 12B12.6 and 5G4.6 that bind the murine TL1A polypeptide.", "Sequencing of the antibody produced by the hybridoma clone designated 1A9 that specifically binds to the human TL1A polypeptide identified the sequences and complementarity determining regions (CDRs) set forth in the following table: SEQ ID DNA or Amino Acid Sequence Description NO CAGATCCAGTTGGTACAGTCTGGACCTGAGCTGAAGAA Heavy Chain DNA sequence 33 GCCCGGAGAGACAGTCAAGATCTCCTGCAAGGCTTCTG GGTATACCTTCACAACCTATGGAATGAGCTGGGTGAAA CAGGCGCCAGGAAAGGGTTTAAAGTGGATGGGCTGGAT GAACACCTACTCTGGAGTGACGACTTATGCTGATGACT TCAAGGGACGGTTTGCCTTCTCTTTGGAAACGTCTGCC AGTACTGCCTATATGCAGATCGACAACCTCAAAAATGA AGACACGGCTACATATTTCTGTGCAAGAGAGGGGTATG TTTTCGACGACTACTATGCTACGGACTACTGGGGTCAA GGAACCTCAGTCACCGTCTCCTCA QIQLVQSGPELKKPGETVKISCKASGYTFTTYGMSWVK Heavy Chain Amino Acid 34 QAPGKGLKWMGWMNTYSGVTTYADDFKGRFAFSLETSA sequence STAYMQIDNLKNEDTATYFCAREGYVFDDYYATDYWGQ GTSVTVSS ACCTATGGAATGAGC Heavy Chain CDR1 DNA 35 sequence TYGMS Heavy Chain CDR1 Amino 36 Acid sequence TGGATGAACACCTACTCTGGAGTGACGACTTATGCTGA Heavy Chain CDR2 DNA 37 TGACTTCAAGGGA sequence WMNTYSGVTTYADDFKG Heavy Chain CDR2 Amino 38 Acid sequence GAGGGGTATGTTTTCGACGACTACTATGCTACGGACTA Heavy Chain CDR3 DNA 39 C sequence EGYVFDDYYATDY Heavy Chain CDR3 Amino 40 Acid sequence GATGTTTTGATGACCCAAACTCCACTCTCCCTGCCTGT Light Chain DNA sequence 41 CAGTCTTGGAGATCAAGCCTCCATCTCTTGCAGATCTA GTCAGAACATTGTACATAGTGATGGAAACACCTATTTA GAATGGTACCTGCAGAAACCAGGCCAGTCTCCAAAACT CCTGATCTACAAAGTTTCCAACCGATTTTCTGGGGTCC CAGACAGGTTCAGTGGCAGTGGATCCGGGACAGATTTC ACACTCAAGATCAGCAGAGTGGAGGCTGAGGATCTGGG AATTTATTACTGCTTTCAAGGTTCACATGTTCCGCTCA CGTTCGGTGCTGGGACCAAGCTGGAGCTGAAA DVLMTQTPLSLPVSLGDQASISCRSSQNIVHSDGNTYL Light Chain Amino Acid 42 EWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDF sequence TLKISRVEAEDLGIYYCFQGSHVPLTFGAGTKLELK AGATCTAGTCAGAACATTGTACATAGTGATGGAAACAC Light Chain CDR1 DNA 43 sequence CTATTTAGAA RSSQNIVHSDGNTYLE Light Chain CDR1 Amino 44 Acid sequence AAAGTTTCCAACCGATTTTCT Light Chain CDR2 DNA 45 sequence KVSNRFS Light Chain CDR2 Amino 46 Acid sequence TTTCAAGGTTCACATGTTCCGCTCACG Light Chain CDR3 DNA 47 sequence FQGSHVPLT Light Chain CDR3 Amino 48 Acid sequence Thus, in one aspect, this disclosure provides a monoclonal antibody or antigen-binding fragment thereof that specifically binds to TL1A and blocks the interaction between DR3 and TL1A wherein the antibody (or antibody fragment) includes an immunoglobulin heavy chain variable region amino acid sequence comprising complementarity determining region (CDR) sequences SEQ ID NO:36, SEQ ID NO:38 and SEQ ID NO:40 and an immunoglobulin light chain variable region amino acid sequence comprising the CDR sequences SEQ ID NO:44, SEQ ID NO:46 and SEQ ID NO:48.These monoclonal antibodies or antigen-binding fragments, may comprise an immunoglobulin heavy chain comprising a variable region amino acid sequence which is at least 90% identical to SEQ ID NO:34, and may be at least 95% identical to SEQ ID NO:34, and may be at least 99% identical to SEQ ID NO:34.These monoclonal antibodies or antigen-binding fragments may comprise an immunoglobulin light chain comprising a variable region amino acid sequence which is at least 90% identical to SEQ ID NO:42, and may be at least 95% identical to SEQ ID NO:42, and may be at least 99% identical to SEQ ID NO:42.These monoclonal antibodies or antigen-binding fragments may comprise an immunoglobulin heavy chain comprising the variable region amino acid sequence of SEQ ID NO:34 and an immunoglobulin light chain comprising a variable region amino acid sequence of SEQ ID NO:42.The antigen-binding fragment may be an scFv.", "The monoclonal antibody may comprise an immunoglobulin heavy chain comprising a variable region amino acid sequence of SEQ ID NO:34 and an immunoglobulin light chain comprising a variable region amino acid sequence of SEQ ID NO:42.The monoclonal antibody may be humanized.", "These antibody or antigen-binding fragments may be conjugated to a detectable label.", "These antibody or antigen-binding fragments may be conjugated to a therapeutic agent, including, for example, a cytotoxin, or a radioactive metal ion.", "This disclosure therefore provides a method of treating an inflammatory or autoimmune disease in a subject, including administering to the subject an effective amount of a monoclonal antibody, or antigen binding fragment thereof, that specifically binds to TL1A and blocks the interaction between DR3 and TL1A wherein the antibody (or antibody fragment) includes an immunoglobulin heavy chain variable region amino acid sequence comprising complementarity determining region (CDR) sequences SEQ ID NO:36, SEQ ID NO:38 and SEQ ID NO:40 and an immunoglobulin light chain variable region amino acid sequence comprising the CDR sequences SEQ ID NO:44, SEQ ID NO:46 and SEQ ID NO:48.The inflammatory or autoimmune disease may be asthma.", "The inflammatory or autoimmune disease may be multiple sclerosis.", "The inflammatory or autoimmune disease may be rheumatoid arthritis.", "The inflammatory or autoimmune disease may be selected from inflammatory bowel disease, type 1 diabetes, graft versus host disease, and autoimmune disease with a T cell component.", "In these methods, the antigen-binding fragment may be an scFv.", "In these methods, the monoclonal antibody may be humanized.", "This disclosure therefore provides an polynucleotide encoding a monoclonal antibody or antigen-binding fragment thereof that specifically binds to TL1A and blocks the interaction between DR3 and TL1A wherein the antibody (or antibody fragment) includes an immunoglobulin heavy chain variable region amino acid sequence comprising complementarity determining region (CDR) sequences SEQ ID NO:36, SEQ ID NO:38 and SEQ ID NO:40 and an immunoglobulin light chain variable region amino acid sequence comprising the CDR sequences SEQ ID NO:44, SEQ ID NO:46 and SEQ ID NO:48.The polynucleotide may encode a heavy chain variable region sequence of SEQ ID NO:34.The polynucleotide may encode the light chain variable region sequence of SEQ ID NO:42.This disclosure also provides a vector comprising a polynucleotide encoding a monoclonal antibody or antigen-binding fragment thereof that specifically binds to TL1A and blocks the interaction between DR3 and TL1A wherein the antibody (or antibody fragment) includes an immunoglobulin heavy chain variable region amino acid sequence comprising complementarity determining region (CDR) sequences SEQ ID NO:36, SEQ ID NO:38 and SEQ ID NO:40 and an immunoglobulin light chain variable region amino acid sequence comprising the CDR sequences SEQ ID NO:44, SEQ ID NO:46 and SEQ ID NO:48.This disclosure also provides pharmaceutical compositions comprising an antibody, or antigen-binding fragment thereof, that specifically binds to TL1A and blocks the interaction between DR3 and TL1A wherein the antibody (or antibody fragment) includes an immunoglobulin heavy chain variable region amino acid sequence comprising complementarity determining region (CDR) sequences SEQ ID NO:36, SEQ ID NO:38 and SEQ ID NO:40 and an immunoglobulin light chain variable region amino acid sequence comprising the CDR sequences SEQ ID NO:44, SEQ ID NO:46 and SEQ ID NO:48, together with a pharmaceutically acceptable carrier.", "Binding characteristics of an antibody include its binding specificity.", "The binding specificity can be specificity for the antigen, or it can be specificity based on the epitope recognized by the antibody.", "Since both the former and the latter are inherent characteristics of an antibody, the disclosure of the present antibodies provides definition of both epitope and antigen specificity.", "Reference to the binding specificity of a deposited monoclonal antibody is the equivalent of reference to the specific epitope on DR3 to which that antibody binds.", "The binding specificity of any individual monoclonal antibody is an inherent property of any other monoclonal antibody of the sub-genus defined by the disclosed, deposited antibody.", "Methods of identifying the binding specificity of a given antibody are well known in the art.", "Further methods of measuring avidity and other characteristics of antibody binding are well known.", "i. Antibodies Generally The term “antibodies” is used herein in a broad sense and includes both polyclonal and monoclonal antibodies.", "In addition to intact immunoglobulin molecules, also included in the term “antibodies” are fragments or polymers of those immunoglobulin molecules, and human or humanized versions of immunoglobulin molecules or fragments thereof, as long as they are chosen for their ability to interact with DR3 or TL1A, such that DR3 is inhibited from interacting with TL1A.", "Antibodies that bind the disclosed regions involved in the interaction between DR3 and TL1A are also disclosed.", "The antibodies can be tested for their desired activity using the in vitro assays described herein, or by analogous methods, after which their in vivo therapeutic and/or prophylactic activities are tested according to known clinical testing methods.", "The term “monoclonal antibody” as used herein refers to an antibody obtained from a substantially homogeneous population of antibodies, i.e., the individual antibodies within the population are identical except for possible naturally occurring mutations that may be present in a small subset of the antibody molecules.", "The monoclonal antibodies herein specifically include “chimeric” antibodies, in which a portion of the heavy and/or light chain is identical with or homologous to corresponding sequences in antibodies derived from a particular species or belonging to a particular antibody class or subclass, while the remainder of the chain(s) is identical with or homologous to corresponding sequences in antibodies derived from another species or belonging to another antibody class or subclass, as well as fragments of such antibodies, as long as they exhibit the desired antagonistic activity (See, U.S. Pat.", "No.", "4,816,567 and Morrison et al., Proc.", "Natl.", "Acad.", "Sci.", "USA, 81:6851-6855 (1984)).", "The disclosed monoclonal antibodies can be made using any procedure which produces monoclonal antibodies.", "For example, disclosed monoclonal antibodies can be prepared using hybridoma methods, such as those described by Kohler and Milstein, Nature, 256:495 (1975).", "In a hybridoma method, a mouse or other appropriate host animal is typically immunized with an immunizing agent to elicit lymphocytes that produce or are capable of producing antibodies that will specifically bind to the immunizing agent.", "Alternatively, the lymphocytes may be immunized in vitro.", "To give the best chance of producing blocking antibodies, the immunizing agents will preferably consist of fully glycosylated native proteins produced by eukaryotic cells.", "For DR3, the extracellular fragment of the human and mouse receptor expressed as an Fc Fusion protein, and cleaved from the Fc portion by a specific protease will be preferably used: Human: amino acids 1-141 of the sequences at Accession No.", "NP_683866.1 (SEQ ID NO:5).", "Mouse: amino acids 1-159 of the sequence at Accession No.", "NP_149031.2 (SEQ ID NO:6).", "For TL1A, the extracellular fragment of the human and mouse TL1A expressed as an epitope-tagged fusion protein will be preferably used: Mouse: Accession No.", "NP_005109.2 (SEQ ID NO:7).", "Human: amino acids 72-251 from the sequence at NP_796345 (SEQ ID NO:8).", "If these approaches do not produce blocking antibodies, cells expressing cell surface-localized versions of these proteins will be used to immunize mice, rats, or other species.", "Traditionally, the generation of monoclonal antibodies has depended on the availability of purified protein or peptides for use as the immunogen.", "More recently, DNA-based immunizations have shown promise as a way to elicit strong immune responses and generate monoclonal antibodies.", "In this approach, DNA-based immunization can be used, wherein DNA encoding extracellular fragments of DR3 and TL1A expressed as a fusion protein with human IgG1 or an epitope tag is injected into the host animal according to methods known in the art (e.g., Kilpatrick K E, et al.", "Gene gun delivered DNA-based immunizations mediate rapid production of murine monoclonal antibodies to the Flt-3 receptor.", "Hybridoma.", "1998 December; 17(6):569-76; Kilpatrick K E et al.", "High-affinity monoclonal antibodies to PED/PEA-15 generated using 5 microg of DNA.", "Hybridoma.", "2000 August; 19(4):297-302, which are incorporated herein by referenced in full for the methods of antibody production) and as described in the examples.", "An alternate approach to immunizations with either purified protein or DNA is to use antigen expressed in baculovirus.", "The advantages to this system include ease of generation, high levels of expression, and post-translational modifications that are highly similar to those seen in mammalian systems.", "Use of this system involves expressing the extracellular domain of TL1A or DR3 as fusion proteins with a signal sequence fragment.", "The antigen is produced by inserting a gene fragment in-frame between the signal sequence and the mature protein domain of the TL1A or DR3 nucleotide sequence.", "This results in the display of the foreign proteins on the surface of the virion.", "This method allows immunization with whole virus, eliminating the need for purification of target antigens.", "Generally, either peripheral blood lymphocytes (“PBLs”) are used in methods of producing monoclonal antibodies if cells of human origin are desired, or spleen cells or lymph node cells are used if non-human mammalian sources are desired.", "The lymphocytes are then fused with an immortalized cell line using a suitable fusing agent, such as polyethylene glycol, to form a hybridoma cell (Goding, “Monoclonal Antibodies: Principles and Practice” Academic Press, (1986) pp.", "59-103).", "Immortalized cell lines are usually transformed mammalian cells, including myeloma cells of rodent, bovine, equine, and human origin.", "Usually, rat or mouse myeloma cell lines are employed.", "The hybridoma cells may be cultured in a suitable culture medium that preferably contains one or more substances that inhibit the growth or survival of the unfused, immortalized cells.", "For example, if the parental cells lack the enzyme hypoxanthine guanine phosphoribosyl transferase (HGPRT or HPRT), the culture medium for the hybridomas typically will include hypoxanthine, aminopterin, and thymidine (“HAT medium”), which substances prevent the growth of HGPRT-deficient cells.", "Preferred immortalized cell lines are those that fuse efficiently, support stable high level expression of antibody by the selected antibody-producing cells, and are sensitive to a medium such as HAT medium.", "More preferred immortalized cell lines are murine myeloma lines, which can be obtained, for instance, from the Salk Institute Cell Distribution Center, San Diego, Calif. and the American Type Culture Collection, Rockville, Md.", "Human myeloma and mouse-human heteromyeloma cell lines also have been described for the production of human monoclonal antibodies (Kozbor, J.", "Immunol., 133:3001 (1984); Brodeur et al., “Monoclonal Antibody Production Techniques and Applications” Marcel Dekker, Inc., New York, (1987) pp.", "51-63).", "The culture medium in which the hybridoma cells are cultured can then be assayed for the presence of monoclonal antibodies directed against DR3 and/or TL1A.", "Preferably, the binding specificity of monoclonal antibodies produced by the hybridoma cells is determined by immunoprecipitation or by an in vitro binding assay, such as radioimmunoassay (RIA) or enzyme-linked immunoabsorbent assay (ELISA).", "Such techniques and assays are known in the art and are described further in the Examples below or in Harlow and Lane “Antibodies, A Laboratory Manual” Cold Spring Harbor Publications, New York, (1988).", "After the desired hybridoma cells are identified, the clones may be subcloned by limiting dilution or FACS sorting procedures and grown by standard methods.", "Suitable culture media for this purpose include, for example, Dulbecco's Modified Eagle's Medium and RPMI-1640 medium.", "Alternatively, the hybridoma cells may be grown in vivo as ascites in a mammal.", "The monoclonal antibodies secreted by the subclones may be isolated or purified from the culture medium or ascites fluid by conventional immunoglobulin purification procedures such as, for example, protein A-Sepharose, protein G, hydroxylapatite chromatography, gel electrophoresis, dialysis, or affinity chromatography.", "The monoclonal antibodies may also be made by recombinant DNA methods, such as those described in U.S. Pat.", "No.", "4,816,567 (Cabilly et al.).", "DNA encoding the disclosed monoclonal antibodies can be readily isolated and sequenced using conventional procedures (e.g., by using oligonucleotide probes that are capable of binding specifically to genes encoding the heavy and light chains of murine antibodies).", "Libraries of antibodies or active antibody fragments can also be generated and screened using phage display techniques, e.g., as described in U.S. Pat.", "No.", "5,804,440 to Burton et al.", "and U.S. Pat.", "No.", "6,096,441 to Barbas et al.", "In vitro methods are also suitable for preparing monovalent antibodies.", "Digestion of antibodies to produce fragments thereof, particularly, Fab fragments, can be accomplished using routine techniques known in the art.", "For instance, digestion can be performed using papain.", "Examples of papain digestion are described in WO 94/29348 published Dec. 22, 1994 and U.S. Pat.", "No.", "4,342,566.Papain digestion of antibodies typically produces two identical antigen binding fragments, called Fab fragments, each with a single antigen binding site and a residual Fc fragment.", "Pepsin treatment yields a fragment that has two antigen combining sites and is still capable of cross-linking antigen.", "The fragments, whether attached to other sequences or not, can also include insertions, deletions, substitutions, or other selected modifications of particular regions or specific amino acids residues, provided the activity of the antibody or antibody fragment is not significantly altered or impaired compared to the non-modified antibody or antibody fragment.", "These modifications can provide for some additional property, such as to remove/add amino acids capable of disulfide bonding, to increase its bio-longevity, to alter its secretory characteristics, etc.", "In any case, the antibody or antibody fragment must possess a bioactive property, such as specific binding to its cognate antigen.", "Functional or active regions of the antibody or antibody fragment may be identified by mutagenesis of a specific region of the protein, followed by expression and testing of the expressed polypeptide.", "Such methods are readily apparent to a skilled practitioner in the art and can include site-specific mutagenesis of the nucleic acid encoding the antibody or antibody fragment.", "(Zoller, M. J. Curr.", "Opin.", "Biotechnol.", "3:348-354, 1992).", "As used herein, the term “antibody” or “antibodies” can also refer to a human antibody and/or a humanized antibody.", "Many non-human antibodies (e.g., those derived from mice, rats, or rabbits) are naturally antigenic in humans and, thus, can give rise to undesirable immune responses when administered to humans.", "Therefore, the use of human or humanized antibodies in the methods serves to lessen the chance that an antibody administered to a human will evoke an undesirable immune response.", "ii.", "Whole Immunoglobulin As used herein, the term “antibody” encompasses, but is not limited to, whole immunoglobulin (i.e., an intact antibody) of any class.", "Native antibodies are usually heterotetrameric glycoproteins composed of two identical light (L) chains and two identical heavy (H) chains.", "Typically, each light chain is linked to a heavy chain by one covalent disulfide bond, while the number of disulfide linkages varies between the heavy chains of different immunoglobulin isotypes.", "Each heavy and light chain also has regularly spaced intrachain disulfide bridges.", "Each heavy chain has, at one end, a variable domain (V(H)) followed by a number of constant domains.", "Each light chain has a variable domain at one end (V(L)) and a constant domain at its other end; the constant domain of the light chain is aligned with the first constant domain of the heavy chain, and the light chain variable domain is aligned with the variable domain of the heavy chain.", "Particular amino acid residues are believed to form an interface between the light and heavy chain variable domains.", "The light chains of antibodies from any vertebrate species can be assigned to one of two clearly distinct types, called kappa (k) and lambda (l), based on the amino acid sequences of their constant domains.", "Depending on the amino acid sequence of the constant domain of their heavy chains, immunoglobulins can be assigned to different classes.", "There are five major classes of human immunoglobulins: IgA, IgD, IgE, IgG and IgM, and several of these may be further divided into subclasses (isotypes), e.g., IgG-1, IgG-2, IgG-3, and IgG-4; IgA-1 and IgA-2.One skilled in the art would recognize the comparable classes for mouse.", "The heavy chain constant domains that correspond to the different classes of immunoglobulins are called alpha, delta, epsilon, gamma, and mu, respectively.", "The term “variable” is used herein to describe certain portions of the variable domains that differ in sequence among antibodies and are used in the binding and specificity of each particular antibody for its particular antigen.", "However, the variability is not usually evenly distributed through the variable domains of antibodies.", "It is typically concentrated in three segments called complementarity determining regions (CDRs) or hypervariable regions both in the light chain and the heavy chain variable domains.", "The more highly conserved portions of the variable domains are called the framework (FR).", "The variable domains of native heavy and light chains each comprise four FR regions, largely adopting a b-sheet configuration, connected by three CDRs, which form loops connecting, and in some cases forming part of, the b-sheet structure.", "The CDRs in each chain are held together in close proximity by the FR regions and, with the CDRs from the other chain, contribute to the formation of the antigen binding site of antibodies (see Kabat E. A. et al., “Sequences of Proteins of Immunological Interest,” National Institutes of Health, Bethesda, Md.", "(1987)).", "The constant domains are not involved directly in binding an antibody to an antigen, but exhibit various effector functions, such as participation of the antibody in antibody-dependent cellular toxicity.", "iii.", "Antibody Fragments The term “antibody” as used herein is meant to include intact molecules as well as fragments thereof, such as, for example, Fab and F(ab′)2, which are capable of binding the epitopic determinant.", "As used herein, the term “antibody or fragments thereof” encompasses chimeric antibodies and hybrid antibodies, with dual or multiple antigen or epitope specificities, and fragments, such as F(ab′)2, Fab′, Fab, and the like, including hybrid fragments.", "Thus, fragments of the antibodies that retain the ability to bind their specific antigens are provided.", "For example, fragments of antibodies which maintain DR3 or TL1A binding activity are included within the meaning of the term “antibody or fragment thereof” Such antibodies and fragments can be made by techniques known in the art and can be screened for specificity and activity according to the methods set forth in the Examples and in general methods for producing antibodies and screening antibodies for specificity and activity (See Harlow and Lane.", "Antibodies, A Laboratory Manual.", "Cold Spring Harbor Publications, New York, (1988)).", "Also included within the meaning of “antibody or fragments thereof” are conjugates of antibody fragments and antigen binding proteins (single chain antibodies) as described, for example, in U.S. Pat.", "No.", "4,704,692, the contents of which are hereby incorporated by reference.", "An isolated immunogenically specific paratope or fragment of the antibody is also provided.", "A specific immunogenic epitope of the antibody can be isolated from the whole antibody by chemical or mechanical disruption of the molecule.", "The purified fragments thus obtained are tested to determine their immunogenicity and specificity by the methods taught herein.", "Immunoreactive paratopes of the antibody, optionally, are synthesized directly.", "An immunoreactive fragment is defined as an amino acid sequence of at least about two to five consecutive amino acids derived from the antibody amino acid sequence.", "Alternatively, unprotected peptide segments are chemically linked where the bond formed between the peptide segments as a result of the chemical ligation is an unnatural (non-peptide) bond (Schnolzer, M et al.", "Science, 256:221 (1992)).", "This technique has been used to synthesize analogs of protein domains, as well as large amounts of relatively pure proteins with full biological activity (deLisle Milton R C et al., Techniques in Protein Chemistry IV.", "Academic Press, New York, pp.", "257-267 (1992)).", "Also disclosed are fragments of antibodies which have bioactivity.", "The polypeptide fragments can be recombinant proteins obtained by cloning nucleic acids encoding the polypeptide in an expression system capable of producing the polypeptide fragments thereof, such as an adenovirus or baculovirus expression system.", "For example, one can determine the active domain of an antibody from a specific hybridoma that can cause a biological effect associated with the interaction of the antibody with TL1A or DR3.For example, amino acids found to not contribute to either the activity or the binding specificity or affinity of the antibody can be deleted without a loss in the respective activity.", "For example, in various embodiments, amino- or carboxy-terminal amino acids are sequentially removed from either the native or the modified non-immunoglobulin molecule or the immunoglobulin molecule and the respective activity assayed in one of many available assays.", "In another example, a fragment of an antibody comprises a modified antibody wherein at least one amino acid has been substituted for the naturally occurring amino acid at a specific position, and a portion of either amino-terminal or carboxy-terminal amino acids, or even an internal region of the antibody, has been replaced with a polypeptide fragment or other moiety, such as biotin, which can facilitate in the purification of the modified antibody.", "For example, a modified antibody can be fused to a maltose binding protein, through either peptide chemistry or cloning the respective nucleic acids encoding the two polypeptide fragments into an expression vector, such that the expression of the coding region results in a hybrid polypeptide.", "The hybrid polypeptide can be affinity purified by passing it over an amylose affinity column, and the modified antibody receptor can then be separated from the maltose binding region by cleaving the hybrid polypeptide with the specific protease factor Xa.", "(See, for example, New England Biolabs Product Catalog, 1996, pg.", "164.).", "Similar purification procedures are available for isolating hybrid proteins from eukaryotic cells as well.", "The fragments, whether attached to other sequences or not, include insertions, deletions, substitutions, or other selected modifications of particular regions or specific amino acid residues, provided the activity of the fragment is not significantly altered or impaired compared to the non-modified antibody or antibody fragment.", "These modifications can provide for some additional property, such as to remove or add amino acids capable of disulfide bonding, to increase its bio-longevity, to alter its secretory characteristics, etc.", "In any case, the fragment must possess a bioactive property, such as binding activity, regulation of binding at the binding domain, etc.", "Functional or active regions of the antibody may be identified by mutagenesis of a specific region of the protein, followed by expression and testing of the expressed polypeptide.", "Such methods are readily apparent to a skilled practitioner in the art and can include site-specific mutagenesis of the nucleic acid encoding the antigen.", "(Zoller M J et al.", "Nucl.", "Acids Res.", "10:6487-500 (1982).", "Techniques can also be adapted for the production of single-chain antibodies specific to an antigenic protein of the present disclosure (see e.g., U.S. Pat.", "No.", "4,946,778).", "In addition, methods can be adapted for the construction of F (ab) expression libraries (see e.g., Huse, et al., 1989 Science 246: 1275-1281) to allow rapid and effective identification of monoclonal F (ab) fragments with the desired specificity for a protein or derivatives, fragments, analogs, or homologs thereof.", "Antibody fragments that contain the idiotypes to a protein antigen may be produced by techniques known in the art including, but not limited to: (i) an F ((ab′))(2) fragment produced by pepsin digestion of an antibody molecule; (ii) an Fab fragment generated by reducing the disulfide bridges of an F ((ab′))(2) fragment; (iii) an F (ab) fragment generated by the treatment of the antibody molecule with papain and a reducing agent and (iv) F (v) fragments.", "Methods for the production of single-chain antibodies are well known to those of skill in the art.", "The skilled artisan is referred to U.S. Pat.", "No.", "5,359,046, (incorporated herein by reference) for such methods.", "A single chain antibody is created by fusing together the variable domains of the heavy and light chains using a short peptide linker, thereby reconstituting an antigen binding site on a single molecule.", "Single-chain antibody variable fragments (scFvs) in which the C-terminus of one variable domain is tethered to the N-terminus of the other variable domain via a 15- to 25-amino acid peptide or linker have been developed without significantly disrupting antigen binding or specificity of the binding (Bedzyk et al., 1990; Chaudhary et al., 1990).", "The linker is chosen to permit the heavy chain and light chain to bind together in their proper conformational orientation.", "See, for example, Huston, J. S., et al., Methods in Enzym.", "203:46-121 (1991), which is incorporated herein by reference.", "These Fvs lack the constant regions (Fc) present in the heavy and light chains of the native antibody.", "iv.", "Monovalent Antibodies In vitro methods are also suitable for preparing monovalent antibodies.", "Digestion of antibodies to produce fragments thereof, particularly, Fab fragments, can be accomplished using routine techniques known in the art.", "For instance, digestion can be performed using papain.", "Examples of papain digestion are described in WO 94/29348 published Dec. 22, 1994, U.S. Pat.", "No.", "4,342,566, and Harlow and Lane, Antibodies, A Laboratory Manual, Cold Spring Harbor Publications, New York, (1988).", "Papain digestion of antibodies typically produces two identical antigen binding fragments, called Fab fragments, each with a single antigen binding site, and a residual Fc fragment.", "Pepsin treatment yields a fragment, called the F(ab′)2 fragment, that has two antigen combining sites and is still capable of cross-linking antigen.", "The Fab fragments produced in the antibody digestion also contain the constant domains of the light chain and the first constant domain of the heavy chain.", "Fab′ fragments differ from Fab fragments by the addition of a few residues at the carboxy terminus of the heavy chain domain including one or more cysteines from the antibody hinge region.", "The F(ab′)2 fragment is a bivalent fragment comprising two Fab′ fragments linked by a disulfide bridge at the hinge region.", "Fab′-SH is the designation herein for Fab′ in which the cysteine residue(s) of the constant domains bear a free thiol group.", "Antibody fragments originally were produced as pairs of Fab′ fragments which have hinge cysteines between them.", "Other chemical couplings of antibody fragments are also known.", "v. Chimeric/Hybrid In hybrid antibodies, one heavy and light chain pair is homologous to that found in an antibody raised against one antigen recognition feature, e.g., epitope, while the other heavy and light chain pair is homologous to a pair found in an antibody raised against another epitope.", "This results in the property of multi-functional valency, i.e., ability to bind at least two different epitopes simultaneously.", "As used herein, the term “hybrid antibody” refers to an antibody wherein each chain is separately homologous with reference to a mammalian antibody chain, but the combination represents a novel assembly, so that two different antigens are recognized by the antibody.", "Such hybrids can be formed by fusion of hybridomas producing the respective component antibodies or by recombinant techniques.", "Such hybrids may, of course, also be formed using chimeric chains.", "vi.", "Anti-Idiotypic The encoded antibodies can be anti-idiotypic antibodies (antibodies that bind other antibodies) as described, for example, in U.S. Pat.", "No.", "4,699,880.Such anti-idiotypic antibodies could bind endogenous or foreign antibodies in a treated individual, thereby to ameliorate or prevent pathological conditions associated with an immune response, e.g., in the context of an autoimmune disease.", "vii.", "Conjugates or Fusions of Antibody Fragments The targeting function of the antibody can be used therapeutically by coupling the antibody or a fragment thereof with a therapeutic agent.", "Such coupling of the antibody or fragment (e.g., at least a portion of an immunoglobulin constant region (Fc)) with the therapeutic agent can be achieved by making an immunoconjugate or by making a fusion protein comprising the antibody or antibody fragment and the therapeutic agent.", "For example, provided is a DR3 Fc fusion protein, e.g., DR3 extracellular domain (150 aa) fused to mouse IgG Fc (DR3 (human)-muIg Fusion Protein).", "Also included within the meaning of “antibody or fragments thereof” are conjugates of antibody fragments and antigen binding proteins (single chain antibodies) as described, for example, in U.S. Pat.", "No.", "4,704,692, the contents of which are hereby incorporated by reference.", "An antibody (or fragment thereof) may be conjugated to a therapeutic moiety such as a cytotoxin, a therapeutic agent, or a radioactive metal ion.", "A cytotoxin or cytotoxic agent includes any agent that is detrimental to cells.", "Examples include taxol, cytochalasin B, gramicidin D, ethidium bromide, emetine, mitomycin, etoposide, tenoposide, vincristine, vinblastine, colchicin, doxorubicin, daunorubicin, dihydroxy anthracin dione, mitoxantrone, mithramycin, actinomycin D, 1-dehydrotestosterone, glucocorticoids, procaine, tetracaine, lidocaine, propranolol, and puromycin and analogs or homologs thereof.", "Therapeutic agents include, but are not limited to, antimetabolites (e.g., methotrexate, 6-mercaptopurine, 6-thioguanine, cytarabine, 5-fluorouracil decarbazine), alkylating agents (e.g., mechlorethamine, thioepa chlorambucil, melphalan, carmustine (BSNU) and lomustine (CCNU), cyclothosphamide, busulfan, dibromomannitol, streptozotocin, mitomycin C, and cis-dichlorodiamine platinum (II) (DDP) cisplatin), anthracyclines (e.g., daunorubicin (formerly daunomycin) and doxorubicin), antibiotics (e.g., dactinomycin (formerly actinomycin), bleomycin, mithramycin, and anthramycin (AMC)), and anti-mitotic agents (e.g., vincristine and vinblastine).", "The conjugates disclosed can be used for modifying a given biological response.", "The drug moiety is not to be construed as limited to classical chemical therapeutic agents.", "For example, the drug moiety may be a protein or polypeptide possessing a desired biological activity.", "Such proteins may include, for example, a toxin such as abrin, ricin A, pseudomonas exotoxin, or diphtheria toxin; a protein such as tumor necrosis factor, [agr]-interferon, [bgr]-interferon, nerve growth factor, platelet derived growth factor, tissue plasminogen activator; or, biological response modifiers such as, for example, lymphokines, interleukin-1 (“IL-1”), interleukin-2 (“IL-2”), interleukin-6 (“IL-6”), granulocyte macrophage colony stimulating factor (“GM-CSF”), granulocyte colony stimulating factor (“G-CSF”), or other growth factors.", "Techniques for conjugating such therapeutic moiety to antibodies are well known, see, e.g., Amon et al., “Monoclonal Antibodies For Immunotargeting Of Drugs In Cancer Therapy”, in Monoclonal Antibodies And Cancer Therapy, Reisfeld et al.", "(eds.", "), pp.", "243-56 (Alan R. Liss, Inc. 1985); Hellstrom et al., “Antibodies For Drug Delivery”, in Controlled Drug Delivery (2nd Ed.", "), Robinson et al.", "(eds.", "), pp.", "623-53 (Marcel Dekker, Inc. 1987); Thorpe, “Antibody Carriers Of Cytotoxic Agents In Cancer Therapy: A Review”, in Monoclonal Antibodies '84: Biological And Clinical Applications, Pinchera et al.", "(eds.", "), pp.", "475-506 (1985); “Analysis, Results, And Future Prospective Of The Therapeutic Use Of Radiolabeled Antibody In Cancer Therapy”, in Monoclonal Antibodies For Cancer Detection And Therapy, Baldwin et al.", "(eds.", "), pp.", "303-16 (Academic Press 1985), and Thorpe et al., “The Preparation And Cytotoxic Properties Of Antibody-Toxin Conjugates”, Immunol.", "Rev., 62:119-58 (1982).", "Alternatively, an antibody can be conjugated to a second antibody to form an antibody heteroconjugate as described by Segal in U.S. Pat.", "No.", "4,676,980.viii.", "Method of Making Antibodies Using Protein Chemistry One method of producing proteins comprising the antibodies is to link two or more peptides or polypeptides together by protein chemistry techniques.", "For example, peptides or polypeptides can be chemically synthesized using currently available laboratory equipment using either Fmoc (9-fluorenylmethyloxycarbonyl) or Boc (tert-butyloxycarbonoyl) chemistry.", "(Applied Biosystems, Inc., Foster City, Calif.).", "One skilled in the art can readily appreciate that a peptide or polypeptide corresponding to the antibody, for example, can be synthesized by standard chemical reactions.", "For example, a peptide or polypeptide can be synthesized and not cleaved from its synthesis resin, whereas the other fragment of an antibody can be synthesized and subsequently cleaved from the resin, thereby exposing a terminal group which is functionally blocked on the other fragment.", "By peptide condensation reactions, these two fragments can be covalently joined via a peptide bond at their carboxyl and amino termini, respectively, to form an antibody or fragment thereof (Grant G A (1992) Synthetic Peptides: A User Guide.", "W.H.", "Freeman and Co., N.Y. (1992); Bodansky M and Trost B., Ed.", "(1993) Principles of Peptide Synthesis.", "Springer-Verlag Inc., NY.", "Alternatively, the peptide or polypeptide is independently synthesized in vivo as described above.", "Once isolated, these independent peptides or polypeptides may be linked to form an antibody or fragment thereof via similar peptide condensation reactions.", "For example, enzymatic ligation of cloned or synthetic peptide segments allow relatively short peptide fragments to be joined to produce larger peptide fragments, polypeptides or whole protein domains (Abrahmsen L et al., Biochemistry, 30:4151 (1991)).", "Alternatively, native chemical ligation of synthetic peptides can be utilized to synthetically construct large peptides or polypeptides from shorter peptide fragments.", "This method consists of a two-step chemical reaction (Dawson et al.", "Synthesis of Proteins by Native Chemical Ligation.", "Science, 266:776-779 (1994)).", "The first step is the chemoselective reaction of an unprotected synthetic peptide-alpha-thioester with another unprotected peptide segment containing an amino-terminal Cys residue to give a thioester-linked intermediate as the initial covalent product.", "Without a change in the reaction conditions, this intermediate undergoes spontaneous, rapid intramolecular reaction to form a native peptide bond at the ligation site.", "Application of this native chemical ligation method to the total synthesis of a protein molecule is illustrated by the preparation of human interleukin 8 (IL-8) (Baggiolini M et al.", "(1992) FEBS Lett.", "307:97-101; Clark-Lewis I et al., J. Biol.", "Chem., 269:16075 (1994); Clark-Lewis I et al., Biochemistry, 30:3128 (1991); Rajarathnam K et al., Biochemistry 33:6623-30 (1994)).", "ix.", "Human and Humanized Transgenic animals (e.g., mice) that are capable, upon immunization, of producing a full repertoire of human antibodies in the absence of endogenous immunoglobulin production can be employed.", "For example, it has been described that the homozygous deletion of the antibody heavy chain joining region (J(H)) gene in chimeric and germ-line mutant mice results in complete inhibition of endogenous antibody production.", "Transfer of the human germ-line immunoglobulin gene array in such germ-line mutant mice will result in the production of human antibodies upon antigen challenge (see, e.g., Jakobovits et al., Proc.", "Natl.", "Acad.", "Sci.", "USA, 90:2551-255 (1993); Jakobovits et al., Nature, 362:255-258 (1993); Bruggemann et al., Year in Immuno., 7:33 (1993)).", "Human antibodies can also be produced in phage display libraries (Hoogenboom et al., J. Mol.", "Biol., 227:381 (1991); Marks et al., J. Mol.", "Biol., 222:581 (1991)).", "The techniques of Cote et al.", "and Boerner et al.", "are also available for the preparation of human monoclonal antibodies (Cole et al., Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, p. 77 (1985); Boerner et al., J.", "Immunol., 147(1):86-95 (1991)).", "Optionally, the antibodies are generated in other species and “humanized” for administration in humans.", "Humanized forms of non-human (e.g., murine) antibodies are chimeric immunoglobulins, immunoglobulin chains, or fragments thereof (such as Fv, Fab, Fab′, F(ab′)2, or other antigen-binding subsequences of antibodies), which contain minimal sequence derived from non-human immunoglobulin.", "Humanized antibodies include human immunoglobulins (recipient antibody) in which residues from a complementarity determining region (CDR) of the recipient antibody are replaced by residues from a CDR of a non-human species (donor antibody) such as mouse, rat, or rabbit having the desired specificity, affinity, and capacity.", "In some instances, Fv framework residues of the human immunoglobulin are replaced by corresponding non-human residues.", "Humanized antibodies may also comprise residues that are found neither in the recipient antibody nor in the imported CDR or framework sequences.", "In general, the humanized antibody will comprise substantially all of at least one, and typically two, variable domains, in which all or substantially all of the CDR regions correspond to those of a non-human immunoglobulin and all or substantially all of the FR regions are those of a human immunoglobulin consensus sequence.", "The humanized antibody optimally also will comprise at least a portion of an immunoglobulin constant region (Fc), typically that of a human immunoglobulin (Jones et al., Nature, 321:522-525 (1986); Riechmann et al., Nature, 332:323-327 (1988); and Presta, Curr.", "Op.", "Struct.", "Biol., 2:593-596 (1992)) Methods for humanizing non-human antibodies are well known in the art.", "Generally, a humanized antibody has one or more amino acid residues introduced into it from a source that is non-human.", "These non-human amino acid residues are often referred to as “import” residues, which are typically taken from an “import” variable domain.", "Antibody humanization techniques generally involve the use of recombinant DNA technology to manipulate the DNA sequence encoding one or more polypeptide chains of an antibody molecule.", "Humanization can be essentially performed following the method of Winter and co-workers (Jones et al., Nature, 321:522-525 (1986); Riechmann et al., Nature, 332:323-327 (1988); Verhoeyen et al., Science, 239:1534-1536 (1988)), by substituting rodent CDRs or CDR sequences for the corresponding sequences of a human antibody.", "Accordingly, a humanized form of a non-human antibody (or a fragment thereof) is a chimeric antibody or fragment (U.S. Pat.", "No.", "4,816,567), wherein substantially less than an intact human variable domain has been substituted with the corresponding sequence from a non-human species.", "In practice, humanized antibodies are typically human antibodies in which some CDR residues and, possibly, some FR residues are substituted with residues from analogous sites in rodent antibodies.", "The choice of human variable domains, both light and heavy, to be used in making the humanized antibodies is very important in order to reduce antigenicity.", "According to the “best-fit” method, the sequence of the variable domain of a rodent antibody is screened against the entire library of known human variable domain sequences.", "The human sequence which is closest to that of the rodent is then accepted as the human framework (FR) for the humanized antibody (Sims et al., J.", "Immunol., 151:2296 (1993) and Chothia et al., J. Mol.", "Biol., 196:901 (1987)).", "Another method uses a particular framework derived from the consensus sequence of all human antibodies of a particular subgroup of light or heavy chains.", "The same framework may be used for several different humanized antibodies (Carter et al., Proc.", "Natl.", "Acad.", "Sci.", "USA, 89:4285 (1992); Presta et al., J.", "Immunol., 151:2623 (1993)).", "It is further important that antibodies be humanized with retention of high affinity for the antigen and other favorable biological properties.", "To achieve this goal, according to a preferred method, humanized antibodies are prepared by a process of analysis of the parental sequences and various conceptual humanized products using three-dimensional models of the parental and humanized sequences.", "Three-dimensional immunoglobulin models are commonly available and are familiar to those skilled in the art.", "Computer programs are available which illustrate and display probable three-dimensional conformational structures of selected candidate immunoglobulin sequences.", "Inspection of these displays permits analysis of the likely role of the residues in the functioning of the candidate immunoglobulin sequence, i.e., the analysis of residues that influence the ability of the candidate immunoglobulin to bind its antigen.", "In this way, FR residues can be selected and combined from the consensus and import sequence so that the desired antibody characteristic, such as increased affinity for the target antigen(s), is achieved.", "In general, the CDR residues are directly and most substantially involved in influencing antigen binding (see, WO 94/04679, published 3 Mar.", "1994).", "Disclosed are antigen-binding polypeptide molecules that bind specifically to the TNF family cytokine TL1A.", "The polypeptides include a humanized heavy chain variable region and a humanized light chain variable region.", "For example, the polypeptides may include the framework (FR) regions of the light and heavy chain variable regions of a human antibody, while retaining substantially the antigen-binding specificity of a parental monoclonal antibody.", "The humanized heavy chain variable region and/or the humanized light chain variable region are at least about 87% humanized, at least about 90% humanized, at least about 95% humanized, at least about 98% humanized, or at least about 100% humanized, excluding the complementary-determining regions (CDRs).", "The antigen-binding polypeptide molecules may be derived from monoclonal antibody donors (e.g., mouse monoclonal antibody donors; human monoclonal antibody donors), and may include CDRs from the monoclonal antibodies (e.g., mouse monoclonal CDRs; human monoclonal CDRs).", "The polypeptides may function as antagonists for the cytokine, TL1A.", "As used herein, the term “epitope” is meant to include any determinant capable of specific interaction with the anti-DR3 or anti-TL1A antibodies disclosed.", "Epitopic determinants usually consist of chemically active surface groupings of molecules such as amino acids or sugar side chains and usually have specific three-dimensional structural characteristics, as well as specific charge characteristics.", "An “epitope tag” denotes a short peptide sequence unrelated to the function of the antibody or molecule that can be used for purification or crosslinking of the molecule with anti-epitope tag antibodies or other reagents.", "By “specifically binds” is meant that an antibody recognizes and physically interacts with its cognate antigen (e.g., a DR3 receptor polypeptide or a TL1A polypeptide) and does not significantly recognize and interact with other antigens; such an antibody may be a polyclonal antibody or a monoclonal antibody, which are generated by techniques that are well known in the art.", "The antibody can be bound to a substrate or labeled with a detectable moiety or both bound and labeled.", "The detectable moieties contemplated with the present compositions include fluorescent, enzymatic, and radioactive markers.", "2.Nucleic Acids i. Sequences There are a variety of sequences related to the protein molecules involved in the signaling pathways disclosed herein, for example DR3 and TL1A, all of which are encoded by nucleic acids or are nucleic acids.", "The sequences for the human analogs of these genes, as well as other analogs, and alleles of these genes, and splice variants and other types of variants, are available in a variety of protein and gene databases, including GENBANK® GENBANK®.", "Those sequences available at the time of filing this application at GENBANK® are herein incorporated by reference in their entireties, as well as for individual subsequences contained therein.", "GENBANK® can be accessed at ncbi.nih.gov/entrez/query.fcgi.", "Those of skill in the art understand how to resolve sequence discrepancies and differences and to adjust the compositions and methods relating to a particular sequence to other related sequences.", "Primers and/or probes can be designed for any given sequence given the information disclosed herein and known in the art.", "Nucleic acid sequences for DR3 can be accessed via GENBANK® Accession No.", "NM_001039664.1 (human) or at Accession No.", "Q93038 (human; SEQ ID NO:1) and NM_033042.3 (mouse).", "Nucleic acid sequences for TL1A can be accessed at via GENBANK® Accession No.", "NM_177371 (mouse) and Accession No.", "NM_005118.2 (human) or at Accession No.", "Q8NFE9 (SEQ ID NO:3).", "All of the information, including any nucleic acid and amino acid sequences provided for DR3 under GENBANK® Accession No.", "NM_001039664.1 (human) and NM_033042.3 (mouse), or for TL1A under GENBANK® Accession No NM_177371 (mouse) and NM_005118.2 (human), is hereby incorporated in its entirety by this reference.", "ii.", "Nucleotides and Related Molecules A nucleotide is a molecule that contains a base moiety, a sugar moiety, and a phosphate moiety.", "Nucleotides can be linked together through their phosphate moieties and sugar moieties, creating an internucleoside linkage.", "The base moiety of a nucleotide can be adenin-9-yl (A), cytosin-1-yl (C), guanin-9-yl (G), uracil-1-yl (U), and thymin-1-yl (T).", "The sugar moiety of a nucleotide is a ribose or a deoxyribose.", "The phosphate moiety of a nucleotide is pentavalent phosphate.", "A non-limiting example of a nucleotide would be 3′-AMP (3′-adenosine monophosphate) or 5′-GMP (5′-guanosine monophosphate).", "There are many varieties of these types of molecules available in the art and available herein.", "The term “nucleotide” includes nucleotides and nucleotide analogs, preferably groups of nucleotides comprising oligonucleotides, and refers to any compound containing a heterocyclic compound bound to a phosphorylated sugar by an N-glycosyl link or any monomer capable of complementary base pairing or any polymer capable of hybridizing to an oligonucleotide.", "The term “nucleotide analog” refers to molecules that can be used in place of naturally occurring bases in nucleic acid synthesis and processing, preferably enzymatic, as well as chemical synthesis and processing, particularly modified nucleotides capable of base pairing.", "A nucleotide analog is a nucleotide which contains some type of modification to one of the base, sugar, or phosphate moieties.", "Modifications to nucleotides are well known in the art and would include, for example, 5-methylcytosine (5 me C), 5-hydroxymethyl cytosine, xanthine, hypoxanthine, and 2-aminoadenine, as well as modifications at the sugar or phosphate moieties.", "This term includes, but is not limited to, modified purines and pyrimidines, minor bases, convertible nucleosides, structural analogs of purines and pyrimidines, labeled, derivatized, and modified nucleosides and nucleotides, conjugated nucleosides and nucleotides, sequence modifiers, terminus modifiers, spacer modifiers, and nucleotides with backbone modifications, including, but not limited to, ribose-modified nucleotides, phosphoramidates, phosphorothioates, phosphonamidites, methyl phosphonates, methyl phosphoramidites, methyl phosphonamidites, 5′-β-cyanoethyl phosphoramidites, methylenephosphonates, phosphorodithioates, peptide nucleic acids, achiral and neutral internucleotidic linkages and nonnucleotide bridges, such as polyethylene glycol, aromatic polyamides and lipids.", "Optionally, a nucleotide analog is a synthetic base that does not comprise adenine, guanine, cytosine, thymidine, uracil, or minor bases.", "These and other nucleotide and nucleoside derivatives, analogs, and backbone modifications are known in the art (e.g., Piccirilli J.", "A. et al.", "(1990) Nature 343:33-37; Sanghvi et al (1993) In: Nucleosides and Nucleotides as Antitumor and Antiviral Agents (Eds.", "C. K. Chu and D. C. Baker) Plenum, New York, pp.", "311-323; Goodchild J.", "(1990)); Bioconjugate Chemistry 1:165-187, Beaucage et al.", "(1993); Tetrahedron 49:1925-1963).", "Nucleotide substitutes are molecules having similar functional properties to nucleotides, but which do not contain a phosphate moiety, such as peptide nucleic acid (PNA).", "Nucleotide substitutes are molecules that will recognize nucleic acids in a Watson-Crick or Hoogsteen manner, but which are linked together through a moiety other than a phosphate moiety.", "Nucleotide substitutes are able to conform to a double helix-type structure when interacting with the appropriate target nucleic acid.", "There are many varieties of these types of molecules available in the art and available herein.", "It is also possible to link other types of molecules (conjugates) to nucleotides or nucleotide analogs to enhance, for example, cellular uptake.", "Conjugates can be chemically linked to the nucleotide or nucleotide analogs.", "Such conjugates include, but are not limited to, lipid moieties such as a cholesterol moiety.", "(Letsinger et al., Proc.", "Natl.", "Acad.", "Sci.", "USA, 1989, 86, 6553-6556).", "There are many varieties of these types of molecules available in the art and available herein.", "There are a variety of molecules disclosed herein that are nucleic acid-based, including, for example, the nucleic acids that encode, for example, TL1A and DR3, as well as any other proteins disclosed herein, as well as various functional nucleic acids.", "The disclosed nucleic acids are made up of, for example, nucleotides, nucleotide analogs, or nucleotide substitutes.", "Non-limiting examples of these and other molecules are discussed herein.", "It is understood that, for example, when a vector is expressed in a cell, the expressed mRNA will typically be made up of A, C, G, and U.", "Likewise, it is understood that if, for example, an antisense molecule is introduced into a cell or cell environment through, for example, exogenous delivery, it is advantageous that the antisense molecule be made up of nucleotide analogs that reduce the degradation of the antisense molecule in the cellular environment.", "By “isolated nucleic acid” or “purified nucleic acid” is meant DNA that is free of the genes that, in the naturally-occurring genome of the organism from which the DNA of the invention is derived, flank the gene.", "The term therefore includes, for example, a recombinant DNA which is incorporated into a vector, such as an autonomously replicating plasmid or virus; or incorporated into the genomic DNA of a prokaryote or eukaryote (e.g., a transgene); or which exists as a separate molecule (e.g., a cDNA or a genomic or cDNA fragment produced by PCR, restriction endonuclease digestion, or chemical or in vitro synthesis).", "It also includes a recombinant DNA, which is part of a hybrid gene encoding additional polypeptide sequence.", "The term “isolated nucleic acid” also refers to RNA, e.g., an mRNA molecule that is encoded by an isolated DNA molecule, or that is chemically synthesized, or that is separated or substantially free from at least some cellular components, e.g., other types of RNA molecules or polypeptide molecules.", "iii.", "Nucleotide Interactions A Watson-Crick interaction is at least one interaction with the Watson-Crick face of a nucleotide, nucleotide analog, or nucleotide substitute.", "The Watson-Crick face of a nucleotide, nucleotide analog, or nucleotide substitute includes the C2, N1, and C6 positions of a purine-based nucleotide, nucleotide analog, or nucleotide substitute and the C2, N3, C4 positions of a pyrimidine based nucleotide, nucleotide analog, or nucleotide substitute.", "A Hoogsteen interaction is the interaction that takes place on the Hoogsteen face of a nucleotide or nucleotide analog, which is exposed in the major groove of duplex DNA.", "The Hoogsteen face includes the N7 position and reactive groups (NH2 or O) at the C6 position of purine nucleotides.", "iv.", "Oligo- and Polynucleotides The term “oligonucleotide” means a naturally occurring or synthetic polymer of nucleotides, preferably a polymer comprising at least three nucleotides and more preferably a polymer capable of hybridization.", "Oligonucleotides may be single-stranded, double-stranded, partially single-stranded, or partially double-stranded ribonucleic or deoxyribonucleic acids, including selected nucleic acid sequences, heteroduplexes, chimeric and hybridized nucleotides, and oligonucleotides conjugated to one or more non-oligonucleotide molecules.", "The term “polynucleotide” is used broadly herein to mean a sequence of two or more deoxyribonucleotides or ribonucleotides that are linked together by a phosphodiester bond.", "As such, the term “polynucleotide” includes RNA and DNA, which can be a gene or a portion thereof, a cDNA, a synthetic polydeoxyribonucleic acid sequence, or the like, and can be single-stranded or double-stranded, as well as a DNA/RNA hybrid.", "Furthermore, the term “polynucleotide” as used herein includes naturally occurring nucleic acid molecules, which can be isolated from a cell, as well as synthetic molecules, which can be prepared, for example, by methods of chemical synthesis or by enzymatic methods such as by the polymerase chain reaction (PCR).", "In various embodiments, a polynucleotide of the invention can contain nucleoside or nucleotide analogs or a backbone bond other than a phosphodiester bond.", "In general, the nucleotides comprising a polynucleotide are naturally occurring deoxyribonucleotides, such as adenine, cytosine, guanine, or thymine linked to 2′-deoxyribose or ribonucleotides such as adenine, cytosine, guanine, or uracil linked to ribose.", "However, a polynucleotide also can contain nucleotide analogs, including non-naturally occurring synthetic nucleotides or modified naturally occurring nucleotides.", "Such nucleotide analogs are well known in the art and commercially available, as are polynucleotides containing such nucleotide analogs (Lin et al., Nucl.", "Acids Res.", "22:5220-5234 (1994); Jellinek et al., Biochemistry 34:11363-11372 (1995); Pagratis et al., Nature Biotechnol.", "15:68-73 (1997), each of which is incorporated herein by reference).", "The covalent bond linking the nucleotides of a polynucleotide generally is a phosphodiester bond.", "However, the covalent bond also can be any of numerous other bonds, including a thiodiester bond, a phosphorothioate bond, a peptide-like bond, or any other bond known to those in the art as useful for linking nucleotides to produce synthetic polynucleotides (see, for example, Tam et al., Nucl.", "Acids Res.", "22:977-986 (1994); Ecker and Crooke, BioTechnology 13:351360 (1995), each of which is incorporated herein by reference).", "The incorporation of non-naturally occurring nucleotide analogs or bonds linking the nucleotides or analogs can be particularly useful where the polynucleotide is to be exposed to an environment that can contain a nucleolytic activity, including, for example, a tissue culture medium or upon administration to a living subject, since the modified polynucleotides can be less susceptible to degradation.", "Functional analogs of naturally occurring polynucleotides can bind to RNA or DNA and include peptide nucleic acid (PNA) molecules.", "A fragment of a reference nucleic acid contains only contiguous nucleic acids of the reference nucleic acid and is at least one nucleotide shorter than the reference sequence.", "v. Primers and Probes Disclosed are compositions including primers and probes, which are capable of interacting with the disclosed nucleic acids, such as the DR3 or TL1A as disclosed herein.", "In certain embodiments, the primers are used to support DNA amplification reactions.", "Typically, the primers will be capable of being extended in a sequence-specific manner.", "Extension of a primer in a sequence-specific manner includes any methods wherein the sequence and/or composition of the nucleic acid molecule to which the primer is hybridized or otherwise associated directs or influences the composition or sequence of the product produced by the extension of the primer.", "Extension of the primer in a sequence-specific manner therefore includes, but is not limited to, PCR, DNA sequencing, DNA extension, DNA polymerization, RNA transcription, or reverse transcription.", "Techniques and conditions that amplify the primer in a sequence-specific manner are preferred.", "In certain embodiments, the primers are used for the DNA amplification reactions, such as PCR or direct sequencing.", "It is understood that, in certain embodiments, the primers can also be extended using non-enzymatic techniques where, for example, the nucleotides or oligonucleotides used to extend the primer are modified such that they will chemically react to extend the primer in a sequence-specific manner.", "Typically, the disclosed primers hybridize with the disclosed nucleic acids or region of the nucleic acids, or they hybridize with the complement of the nucleic acids or complement of a region of the nucleic acids.", "The size of the primers or probes for interaction with the nucleic acids in certain embodiments can be any size that supports the desired enzymatic manipulation of the primer, such as DNA amplification or the simple hybridization of the probe or primer.", "A typical primer or probe would be at least 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 125, 150, 175, 200, 225, 250, 275, 300, 325, 350, 375, 400, 425, 450, 475, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000, 1250, 1500, 1750, 2000, 2250, 2500, 2750, 3000, 3500, or 4000 nucleotides long.", "In other embodiments, a primer or probe can be less than or equal to 6, 7, 8, 9, 10, 11, 12 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 125, 150, 175, 200, 225, 250, 275, 300, 325, 350, 375, 400, 425, 450, 475, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000, 1250, 1500, 1750, 2000, 2250, 2500, 2750, 3000, 3500, or 4000 nucleotides long.", "The primers for the DR3 or TL1A gene typically will be used to produce an amplified DNA product that contains a region of the DR3 or TL1A gene or the complete gene.", "Typically, the size of the product will be such that the size can be accurately determined to within 3, 2, or 1 nucleotide(s).", "In certain embodiments, this product is at least 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 125, 150, 175, 200, 225, 250, 275, 300, 325, 350, 375, 400, 425, 450, 475, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000, 1250, 1500, 1750, 2000, 2250, 2500, 2750, 3000, 3500, or 4000 nucleotides long.", "In other embodiments, the product is less than or equal to 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 125, 150, 175, 200, 225, 250, 275, 300, 325, 350, 375, 400, 425, 450, 475, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000, 1250, 1500, 1750, 2000, 2250, 2500, 2750, 3000, 3500, or 4000 nucleotides long.", "3.Peptides i.", "Protein Variants As discussed herein, there are numerous variants of the DR3 protein and TL1A protein that are known and herein contemplated.", "In addition to the known functional strain variants, there are derivatives of the DR3 or TL1A proteins which also function in the disclosed methods and compositions.", "Protein variants and derivatives are well understood to those of skill in the art and can involve amino acid sequence modifications.", "For example, amino acid sequence modifications typically fall into one or more of three classes: substitutional, insertional, or deletional variants.", "Insertions include amino- and/or carboxyl-terminal fusions, as well as intrasequence insertions of single or multiple amino acid residues.", "Insertions ordinarily will be smaller insertions than those of amino or carboxyl terminal fusions, for example, on the order of one to four residues.", "Immunogenic fusion protein derivatives, such as those described in the examples, are made by fusing a polypeptide sufficiently large to confer immunogenicity to the target sequence by cross-linking in vitro or by recombinant cell culture transformed with DNA encoding the fusion.", "Deletions are characterized by the removal of one or more amino acid residues from the protein sequence.", "Typically, no more than about from 2 to 6 residues are deleted at any one site within the protein molecule.", "These variants ordinarily are prepared by site-specific mutagenesis of nucleotides in the DNA encoding the protein, thereby producing DNA encoding the variant and, thereafter, expressing the DNA in recombinant cell culture.", "Techniques for making substitution mutations at predetermined sites in DNA having a known sequence are well known, for example, M13 primer mutagenesis and PCR mutagenesis.", "Amino acid substitutions are typically of single residues, but can occur at a number of different locations at once; insertions usually will be on the order of about from 1 to 10 amino acid residues; and deletions will range about from 1 to 30 residues.", "Deletions or insertions preferably are made in adjacent pairs, i.e.", "a deletion of 2 residues or insertion of 2 residues.", "Substitutions, deletions, insertions, or any combination thereof may be combined to arrive at a final construct.", "The mutations must not place the sequence out of reading frame and, preferably, will not create complementary regions that could produce secondary mRNA structure.", "Substitutional variants are those in which at least one residue has been removed, and a different residue inserted in its place.", "Such substitutions generally are made in accordance with the following Tables 1 and 2 and are referred to as conservative substitutions.", "TABLE 2 Amino Acid Abbreviations Amino Acid Abbreviations Alanine Ala A alloisoleucine AIle Arginine Arg R asparagine Asn N aspartic acid Asp D Cysteine Cys C glutamic acid Glu E Glutamine Gln Q Glycine Gly G Histidine His H Isoleucine Ile I Leucine Leu L Lysine Lys K phenylalanine Phe F proline Pro P pyroglutamic acid pGlu Serine Ser S Threonine Thr T Tyrosine Tyr Y Tryptophan Trp W Valine Val V TABLE 3 Amino Acid Substitutions Exemplary Conservative Substitutions, Original Residue others are known in the art.", "Ala Ser Arg Lys; Gln Asn Gln; His Asp Glu Cys Ser Gln Asn, Lys Glu Asp Gly Pro His Asn; Gln Ile Leu; Val Leu Ile; Val Lys Arg; Gln Met Leu; Ile Phe Met; Leu; Tyr Ser Thr Thr Ser Trp Tyr Tyr Trp; Phe Val Ile; Leu Substantial changes in function or immunological identity are made by selecting substitutions that are less conservative than those in Table 3, i.e., selecting residues that differ more significantly in their effect on maintaining (a) the structure of the polypeptide backbone in the area of the substitution, for example, as a sheet or helical conformation, (b) the charge or hydrophobicity of the molecule at the target site, or (c) the bulk of the side chain.", "The substitutions which, in general, are expected to produce the greatest changes in the protein properties will be those in which (a) a hydrophilic residue, e.g.", "seryl or threonyl, is substituted for (or by) a hydrophobic residue, e.g.", "leucyl, isoleucyl, phenylalanyl, valyl or alanyl; (b) a cysteine or proline is substituted for (or by) any other residue; (c) a residue having an electropositive side chain, e.g., lysyl, arginyl, or histidyl, is substituted for (or by) an electronegative residue, e.g., glutamyl or aspartyl; (d) a residue having a bulky side chain, e.g., phenylalanine, is substituted for (or by) one not having a side chain, e.g., glycine, in this case; or (e) by increasing the number of sites for sulfation and/or glycosylation.", "For example, the replacement of one amino acid residue with another that is biologically and/or chemically similar is known to those skilled in the art as a conservative substitution.", "For example, a conservative substitution would be replacing one hydrophobic residue for another, or one polar residue for another.", "The substitutions include combinations such as, for example, Gly, Ala; Val, Ile, Leu; Asp, Glu; Asn, Gln; Ser, Thr; Lys, Arg; and Phe, Tyr.", "Such conservatively substituted variations of each explicitly disclosed sequence are included within the mosaic polypeptides provided herein.", "Substitutional or deletional mutagenesis can be employed to insert sites for N-glycosylation (Asn-X-Thr/Ser) or O-glycosylation (Ser or Thr).", "Deletions of cysteine or other labile residues also may be desirable.", "Deletions or substitutions of potential proteolysis sites, e.g.", "Arg, are accomplished, for example, by deleting one of the basic residues or substituting one by glutaminyl or histidyl residues.", "Certain post-translational derivatizations are the result of the action of recombinant host cells on the expressed polypeptide.", "Glutaminyl and asparaginyl residues are frequently post-translationally deamidated to the corresponding glutamyl and asparyl residues.", "Alternatively, these residues are deamidated under mildly acidic conditions.", "Other post-translational modifications include hydroxylation of proline and lysine, phosphorylation of hydroxyl groups of seryl or threonyl residues, methylation of the o-amino groups of lysine, arginine, and histidine side chains (T. E. Creighton, Proteins: Structure and Molecular Properties, W. H. Freeman & Co., San Francisco pp 79-86 [1983]), acetylation of the N-terminal amine and, in some instances, amidation of the C-terminal carboxyl.", "It is understood that one way to define the variants and derivatives of the disclosed proteins herein is through defining the variants and derivatives in terms of homology/identity to specific known sequences.", "For example, SEQ ID NO:2 sets forth a particular sequence of DR3, and SEQ ID NO:4 sets forth a particular sequence of TL1A protein.", "Specifically disclosed are variants of these and other proteins herein disclosed which have at least 70% or 75% or 80% or 85% or 90% or 95% homology to the stated sequence.", "Those of skill in the art readily understand how to determine the homology of two proteins.", "For example, the homology can be calculated after aligning the two sequences, so that the homology is at its highest level.", "Another way of calculating homology can be performed by published algorithms.", "Optimal alignment of sequences for comparison may be conducted by the local homology algorithm of Smith and Waterman Adv.", "Appl.", "Math.", "2: 482 (1981), by the homology alignment algorithm of Needleman and Wunsch, J. MoL Biol.", "48: 443 (1970), by the search for similarity method of Pearson and Lipman, Proc.", "Natl.", "Acad.", "Sci.", "U.S.A. 85: 2444 (1988), by computerized implementations of these algorithms (GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin Genetics Software Package, Genetics Computer Group, 575 Science Dr., Madison, Wis.), or by inspection.", "The same types of homology can be obtained for nucleic acids by, for example, the algorithms disclosed in Zuker, M. Science 244:48-52, 1989, Jaeger et al.", "Proc.", "Natl.", "Acad.", "Sci.", "USA 86:7706-7710, 1989, Jaeger et al.", "Methods Enzymol.", "183:281-306, 1989, which are herein incorporated by reference for at least material related to nucleic acid alignment.", "It is understood that the description of conservative mutations and homology can be combined together in any combination, such as embodiments that have at least 70% homology to a particular sequence, wherein the variants are conservative mutations.", "As this specification discusses various proteins and protein sequences, it is understood that the nucleic acids that can encode those protein sequences are also disclosed.", "This would include all degenerate sequences related to a specific protein sequence, i.e.", "all nucleic acids having a sequence that encodes one particular protein sequence, as well as all nucleic acids, including degenerate nucleic acids, encoding the disclosed variants and derivatives of the protein sequences.", "Thus, while each particular nucleic acid sequence may not be written out herein, it is understood that each and every sequence is, in fact, disclosed and described herein through the disclosed protein sequence.", "It is also understood that while no amino acid sequence indicates what particular DNA sequence encodes that protein within an organism, where particular variants of a disclosed protein are disclosed herein, the known nucleic acid sequence that encodes that protein is also known and herein disclosed and described.", "It is understood that there are numerous amino acid and peptide analogs which can be incorporated into the disclosed compositions.", "For example, there are numerous D amino acids or amino acids which have a different functional substituent than the amino acids shown in Table 2 and Table 3.The opposite stereoisomers of naturally occurring peptides are disclosed, as well as the stereoisomers of peptide analogs.", "These amino acids can readily be incorporated into polypeptide chains by charging tRNA molecules with the amino acid of choice and engineering genetic constructs that utilize, for example, amber codons to insert the analog amino acid into a peptide chain in a site-specific way (Thorson et al., Methods in Molec.", "Biol.", "77:43-73 (1991), Zoller, Current Opinion in Biotechnology, 3:348-354 (1992); Ibba, Biotechnology & Genetic Engineering Reviews 13:197-216 (1995), Cahill et al., TIBS, 14(10):400-403 (1989); Benner, TIB Tech, 12:158-163 (1994); Ibba and Hennecke, Bio/technology, 12:678-682 (1994), all of which are herein incorporated by reference at least for material related to amino acid analogs).", "Molecules can be produced that resemble peptides, but which are not connected via a natural peptide linkage.", "For example, linkages for amino acids or amino acid analogs can include CH2NH—, —CH2S—, —CH2—CH2—, —CH═CH— (cis and trans), —COCH2—, —CH(OH)CH2—, and —CHH2SO— (these and others can be found in Spatola, A. F. in Chemistry and Biochemistry of Amino Acids, Peptides, and Proteins, B. Weinstein, eds., Marcel Dekker, New York, p. 267 (1983); Spatola, A. F., Vega Data (March 1983), Vol.", "1, Issue 3, Peptide Backbone Modifications (general review); Morley, Trends Pharm Sci (1980) pp.", "463-468; Hudson, D. et al., Int J Pept Prot Res 14:177-185 (1979) (—CH2NH—, CH2CH2—); Spatola et al.", "Life Sci 38:1243-1249 (1986) (—CHH2—S); Hann J. Chem.", "Soc Perkin Trans.", "I 307-314 (1982) (—CH—CH—, cis and trans); Almquist et al.", "J. Med.", "Chem.", "23:1392-1398 (1980) (—COCH2—); Jennings-White et al.", "Tetrahedron Lett 23:2533 (1982) (—COCH2—); Szelke et al.", "European Appln, EP 45665 CA (1982): 97:39405 (1982) (—CH(OH)CH2—); Holladay et al.", "Tetrahedron.", "Lett 24:4401-4404 (1983) (—C(OH)CH2—); and Hruby Life Sci 31:189-199 (1982) (—CH2—S—); each of which is incorporated herein by reference.", "A particularly preferred non-peptide linkage is —CH2NH—.", "It is understood that peptide analogs can have more than one atom between the bond atoms, such as b-alanine, g-aminobutyric acid, and the like.", "Amino acid analogs and analogs and peptide analogs often have enhanced or desirable properties, such as more economical production, greater chemical stability, enhanced pharmacological properties (half-life, absorption, potency, efficacy, etc.", "), altered specificity (e.g., a broad spectrum of biological activities), reduced antigenicity, and others.", "D-amino acids can be used to generate more stable peptides, because D-amino acids are not recognized by peptidases and such.", "Systematic substitution of one or more amino acids of a consensus sequence with a D-amino acid of the same type (e.g., D-lysine in place of L-lysine) can be used to generate more stable peptides.", "Cysteine residues can be used to cyclize or attach two or more peptides together.", "This can be beneficial to constrain peptides into particular conformations.", "(Rizo and Gierasch Ann.", "Rev.", "Biochem.", "61:387 (1992), incorporated herein by reference).", "4.Sequence Similarities It is understood that, as discussed herein, the use of the terms homology and identity mean the same thing as similarity.", "Thus, for example, if the use of the word homology is used between two non-natural sequences, it is understood that this is not necessarily indicating an evolutionary relationship between these two sequences but, rather, is looking at the similarity or relatedness between their nucleic acid sequences.", "Many of the methods for determining homology between two evolutionarily related molecules are routinely applied to any two or more nucleic acids or proteins for the purpose of measuring sequence similarity, regardless of whether they are evolutionarily related or not.", "In general, it is understood that one way to define any known variants and derivatives or those that might arise, of the disclosed genes and proteins herein, is through defining the variants and derivatives in terms of homology to specific known sequences.", "This identity of particular sequences disclosed herein is also discussed elsewhere herein.", "In general, variants of genes and proteins herein disclosed typically have at least, about 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, or 99 percent homology to the stated sequence or the native sequence.", "Those of skill in the art readily understand how to determine the homology of two proteins or nucleic acids, such as genes.", "For example, the homology can be calculated after aligning the two sequences so that the homology is at its highest level.", "Another way of calculating homology can be performed by published algorithms.", "Optimal alignment of sequences for comparison may be conducted by the local homology algorithm of Smith and Waterman Adv.", "Appl.", "Math.", "2: 482 (1981), by the homology alignment algorithm of Needleman and Wunsch, J. MoL Biol.", "48: 443 (1970), by the search for similarity method of Pearson and Lipman, Proc.", "Natl.", "Acad.", "Sci.", "U.S.A. 85: 2444 (1988), by computerized implementations of these algorithms (GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin Genetics Software Package, Genetics Computer Group, 575 Science Dr., Madison, Wis.), or by inspection.", "The same types of homology can be obtained for nucleic acids by, for example, the algorithms disclosed in Zuker, M. Science 244:48-52, 1989, Jaeger et al.", "Proc.", "Natl.", "Acad.", "Sci.", "USA 86:7706-7710, 1989, Jaeger et al.", "Methods Enzymol.", "183:281-306, 1989, which are herein incorporated by reference for at least material related to nucleic acid alignment.", "It is understood that any of the methods typically can be used and that in certain instances the results of these various methods may differ, but the skilled artisan understands if identity is found with at least one of these methods, the sequences would be said to have the stated identity, and be disclosed herein.", "For example, as used herein, a sequence recited as having a particular percent homology to another sequence refers to sequences that have the recited homology as calculated by any one or more of the calculation methods described above.", "For example, a first sequence has 80 percent homology, as defined herein, to a second sequence if the first sequence is calculated to have 80 percent homology to the second sequence using the Zuker calculation method, even if the first sequence does not have 80 percent homology to the second sequence as calculated by any of the other calculation methods.", "As another example, a first sequence has 80 percent homology, as defined herein, to a second sequence if the first sequence is calculated to have 80 percent homology to the second sequence using both the Zuker calculation method and the Pearson and Lipman calculation method, even if the first sequence does not have 80 percent homology to the second sequence as calculated by the Smith and Waterman calculation method, the Needleman and Wunsch calculation method, the Jaeger calculation methods, or any of the other calculation methods.", "As yet another example, a first sequence has 80 percent homology, as defined herein, to a second sequence if the first sequence is calculated to have 80 percent homology to the second sequence using each of calculation methods (although, in practice, the different calculation methods will often result in different calculated homology percentages).", "5.Hybridization/Selective Hybridization The term hybridization typically means a sequence-driven interaction between at least two nucleic acid molecules, such as a primer or a probe and a gene.", "Sequence-driven interaction means an interaction that occurs between two nucleotides or nucleotide analogs or nucleotide derivatives in a nucleotide-specific manner.", "For example, G interacting with C or A interacting with T are sequence-driven interactions.", "Typically, sequence-driven interactions occur on the Watson-Crick face or Hoogsteen face of the nucleotide.", "The hybridization of two nucleic acids is affected by a number of conditions and parameters known to those of skill in the art.", "For example, the salt concentrations, pH, and temperature of the reaction all affect whether two nucleic acid molecules will hybridize.", "Parameters for selective hybridization between two nucleic acid molecules are well known to those of skill in the art.", "For example, in some embodiments, selective hybridization conditions can be defined as stringent hybridization conditions.", "For example, stringency of hybridization is controlled by both temperature and salt concentration of either or both of the hybridization and washing steps.", "For example, the conditions of hybridization to achieve selective hybridization may involve hybridization in high ionic strength solution (6×SSC or 6×SSPE) at a temperature that is about 12-25° C. below the Tm (the melting temperature at which half of the molecules dissociate from their hybridization partners) followed by washing at a combination of temperature and salt concentration chosen so that the washing temperature is about 5° C. to 20° C. below the Tm.", "The temperature and salt conditions are readily determined empirically in preliminary experiments in which samples of reference DNA immobilized on filters are hybridized to a labeled nucleic acid of interest and then washed under conditions of different stringencies.", "Hybridization temperatures are typically higher for DNA-RNA and RNA-RNA hybridizations.", "The conditions can be used as described above to achieve stringency or as is known in the art.", "(Sambrook et al., Molecular Cloning: A Laboratory Manual, 2nd Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., 1989; Kunkel et al.", "Methods Enzymol.", "1987:154:367, 1987, which is herein incorporated by reference for material at least related to hybridization of nucleic acids).", "A preferable stringent hybridization condition for a DNA:DNA hybridization can be at about 68° C. (in aqueous solution) in 6×SSC or 6×SSPE followed by washing at 68° C. Stringency of hybridization and washing, if desired, can be reduced accordingly as the degree of complementarity desired is decreased, and further, depending upon the G-C or A-T richness of any area wherein variability is searched for.", "Likewise, stringency of hybridization and washing, if desired, can be increased accordingly as homology desired is increased, and further, depending upon the G-C or A-T richness of any area wherein high homology is desired, all as known in the art.", "Another way to define selective hybridization is by looking at the amount (percentage) of one of the nucleic acids bound to the other nucleic acid.", "For example, in some embodiments, selective hybridization conditions would be when at least about 60, 65, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100 percent of the limiting nucleic acid is bound to the non-limiting nucleic acid.", "Typically, the non-limiting primer is in, for example, 10- or 100- or 1000-fold excess.", "This type of assay can be performed under conditions where both the limiting and non-limiting primer are, for example, 10-fold or 100-fold or 1000-fold below their kd, or where only one of the nucleic acid molecules is 10-fold or 100-fold or 1000-fold or where one or both nucleic acid molecules are above their kd.", "Another way to define selective hybridization is by looking at the percentage of primer that gets enzymatically manipulated under conditions where hybridization is required to promote the desired enzymatic manipulation.", "For example, in some embodiments, selective hybridization conditions would be when at least about 60, 65, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100 percent of the primer is enzymatically manipulated under conditions which promote the enzymatic manipulation, for example, if the enzymatic manipulation is DNA extension, then selective hybridization conditions would be when at least about 60, 65, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100 percent of the primer molecules are extended.", "Preferred conditions also include those suggested by the manufacturer or indicated in the art as being appropriate for the enzyme performing the manipulation.", "Just as with homology, it is understood that there are a variety of methods herein disclosed for determining the level of hybridization between two nucleic acid molecules.", "It is understood that these methods and conditions may provide different percentages of hybridization between two nucleic acid molecules but, unless otherwise indicated, meeting the parameters of any of the methods would be sufficient.", "For example, if 80% hybridization was required, and as long as hybridization occurs within the required parameters in any one of these methods, it is considered disclosed herein.", "It is understood that those of skill in the art understand that if a composition or method meets any one of these criteria for determining hybridization either collectively or singly, it is a composition or method that is disclosed herein.", "6.Cell Delivery Systems There are a number of compositions and methods which can be used to deliver nucleic acids to cells, either in vitro or in vivo.", "These methods and compositions can largely be broken down into two classes: viral-based delivery systems and non-viral-based delivery systems.", "For example, the nucleic acids can be delivered through a number of direct delivery systems, such as electroporation, lipofection, calcium phosphate precipitation, plasmids, viral vectors, viral nucleic acids, phage nucleic acids, phages, cosmids, or via transfer of genetic material in cells or carriers such as cationic liposomes.", "Appropriate means for transfection, including viral vectors, chemical transfectants, or physico-mechanical methods such as electroporation and direct diffusion of DNA, are described by, for example, Wolff, J.", "A., et al., Science, 247, 1465-1468, (1990); and Wolff, J.", "A.", "Nature, 352, 815-818, (1991).", "Such methods are well known in the art and readily adaptable for use with the compositions and methods described herein.", "In certain cases, the methods will be modified to specifically function with large DNA molecules.", "Further, these methods can be used to target certain diseases and cell populations by using the targeting characteristics of the carrier.", "i. Nucleic Acid-Based Delivery Systems Transfer vectors can be any nucleotide construction used to deliver genes into cells (e.g., a plasmid), or as part of a general strategy to deliver genes, e.g., as part of recombinant retrovirus or adenovirus (Ram et al.", "Cancer Res.", "53:83-88, (1993)).", "As used herein, plasmid or viral vectors are agents that transport the disclosed nucleic acids, such as DR3 or TL1A, into the cell without degradation and include a promoter yielding expression of the gene in the cells into which it is delivered.", "In some embodiments, the vectors are derived from either a virus or a retrovirus.", "Viral vectors are, for example, Adenovirus, Adeno-associated virus, Herpes virus, Vaccinia virus, Polio virus, AIDS virus, neuronal trophic virus, Sindbis, and other RNA viruses, including these viruses with the HIV backbone.", "Also preferred are any viral families which share the properties of these viruses which make them suitable for use as vectors.", "Retroviruses include Murine Maloney Leukemia virus, MMLV, and retroviruses that express the desirable properties of MMLV as a vector.", "Retroviral vectors are able to carry a larger genetic payload, i.e., a transgene or marker gene, than other viral vectors and, for this reason, are a commonly used vector.", "However, they are not as useful in non-proliferating cells.", "Adenovirus vectors are relatively stable and easy to work with, have high titers, can be delivered in aerosol formulation, and can transfect non-dividing cells.", "Pox viral vectors are large and have several sites for inserting genes; they are thermostable and can be stored at room temperature.", "A preferred embodiment is a viral vector which has been engineered so as to suppress the immune response of the host organism, elicited by the viral antigens.", "Preferred vectors of this type will carry coding regions for Interleukin 8 or 10.Viral vectors can have higher transaction (ability to introduce genes) abilities than chemical or physical methods to introduce genes into cells.", "Typically, viral vectors contain non-structural early genes, structural late genes, an RNA polymerase III transcript, inverted terminal repeats necessary for replication and encapsidation, and promoters to control the transcription and replication of the viral genome.", "When engineered as vectors, viruses typically have one or more of the early genes removed, and a gene or gene/promotor cassette is inserted into the viral genome in place of the removed viral DNA.", "Constructs of this type can carry up to about 8 kb of foreign genetic material.", "The necessary functions of the removed early genes are typically supplied by cell lines which have been engineered to express the gene products of the early genes in trans.", "a. Retroviral Vectors A retrovirus is an animal virus belonging to the virus family of Retroviridae, including any types, subfamilies, genus, or tropisms.", "Retroviral vectors, in general, are described by Verma, I. M., Retroviral vectors for gene transfer.", "In Microbiology-1985, American Society for Microbiology, pp.", "229-232, Washington, (1985), which is incorporated by reference herein.", "Examples of methods for using retroviral vectors for gene therapy are described in U.S. Pat.", "Nos.", "4,868,116 and 4,980,286; PCT applications WO 90/02806 and WO 89/07136; and Mulligan, (Science 260:926-932 (1993)), the teachings of which are incorporated herein by reference.", "A retrovirus is essentially a package which has packed into it nucleic acid cargo.", "The nucleic acid cargo carries with it a packaging signal, which ensures that the replicated daughter molecules will be efficiently packaged within the package coat.", "In addition to the package signal, there are a number of molecules which are needed in cis for the replication and packaging of the replicated virus.", "Typically, a retroviral genome contains the gag, pol, and env genes, which are involved in the making of the protein coat.", "It is the gag, pol, and env genes which are typically replaced by the foreign DNA that it is to be transferred to the target cell.", "Retrovirus vectors typically contain a packaging signal for incorporation into the package coat, a sequence which signals the start of the gag transcription unit, elements necessary for reverse transcription, including a primer binding site to bind the tRNA primer of reverse transcription, terminal repeat sequences that guide the switch of RNA strands during DNA synthesis, a purine-rich sequence 5′ to the 3′ LTR that serves as the priming site for the synthesis of the second strand of DNA synthesis, and specific sequences near the ends of the LTRs that enable the insertion of the DNA state of the retrovirus to insert into the host genome.", "The removal of the gag, pol, and env genes allows for about 8 kb of foreign sequence to be inserted into the viral genome, become reverse transcribed and, upon replication, be packaged into a new retroviral particle.", "This amount of nucleic acid is sufficient for the delivery of one to many genes depending on the size of each transcript.", "It is preferable to include either positive or negative selectable markers along with other genes in the insert.", "Since the replication machinery and packaging proteins in most retroviral vectors have been removed (gag, pol, and env), the vectors are typically generated by placing them into a packaging cell line.", "A packaging cell line is a cell line which has been transfected or transformed with a retrovirus that contains the replication and packaging machinery, but lacks any packaging signal.", "When the vector carrying the DNA of choice is transfected into these cell lines, the vector containing the gene of interest is replicated and packaged into new retroviral particles by the machinery provided in cis by the helper cell.", "The genomes for the machinery are not packaged because they lack the necessary signals.", "b. Adenoviral Vectors The construction of replication-defective adenoviruses has been described (Berkner et al., J. Virology 61:1213-1220 (1987); Massie et al., Mol.", "Cell.", "Biol.", "6:2872-2883 (1986); Haj-Ahmad et al., J. Virology 57:267-274 (1986); Davidson et al., J. Virology 61:1226-1239 (1987); Zhang “Generation and identification of recombinant adenovirus by liposome-mediated transfection and PCR analysis” BioTechniques 15:868-872 (1993)).", "The benefit of the use of these viruses as vectors is that they are limited in the extent to which they can spread to other cell types, since they can replicate within an initial infected cell, but are unable to form new infectious viral particles.", "Recombinant adenoviruses have been shown to achieve high efficiency gene transfer after direct, in vivo delivery to airway epithelium, hepatocytes, vascular endothelium, CNS parenchyma, and a number of other tissue sites (Morsy, J. Clin.", "Invest.", "92:1580-1586 (1993); Kirshenbaum, J. Clin.", "Invest.", "92:381-387 (1993); Roessler, J. Clin.", "Invest.", "92:1085-1092 (1993); Moullier, Nature Genetics 4:154-159 (1993); La Salle, Science 259:988-990 (1993); Gomez-Foix, J. Biol.", "Chem.", "267:25129-25134 (1992); Rich, Human Gene Therapy 4:461-476 (1993); Zabner, Nature Genetics 6:75-83 (1994); Guzman, Circulation Research 73:1201-1207 (1993); Bout, Human Gene Therapy 5:3-10 (1994); Zabner, Cell 75:207-216 (1993); Caillaud, Eur.", "J. Neuroscience 5:1287-1291 (1993); and Ragot, J. Gen. Virology 74:501-507 (1993)).", "Recombinant adenoviruses achieve gene transduction by binding to specific cell surface receptors, after which the virus is internalized by receptor-mediated endocytosis, in the same manner as wild-type or replication-defective adenovirus (Chardonnet and Dales, Virology 40:462-477 (1970); Brown and Burlingham, J. Virology 12:386-396 (1973); Svensson and Persson, J. Virology 55:442-449 (1985); Seth, et al., J. Virol.", "51:650-655 (1984); Seth, et al., Mol.", "Cell.", "Biol.", "4:1528-1533 (1984); Varga et al., J. Virology 65:6061-6070 (1991); Wickham et al., Cell 73:309-319 (1993)).", "A viral vector can be one based on an adenovirus which has had the E1 gene removed, and these virons are generated in a cell line such as the human 293 cell line.", "In another preferred embodiment, both the E1 and E3 genes are removed from the adenovirus genome.", "c. Adeno-Associated Viral Vectors Another type of viral vector is based on an adeno-associated virus (AAV).", "This defective parvovirus is a preferred vector because it can infect many cell types and is non-pathogenic to humans.", "AAV type vectors can transport about 4 to 5 kb, and wild-type AAV is known to stably insert into chromosome 19.Vectors which contain this site-specific integration property are preferred.", "An especially preferred embodiment of this type of vector is the P4.1 C vector produced by Avigen, San Francisco, Calif., which can contain the herpes simplex virus thymidine kinase gene, HSV-tk, and/or a marker gene, such as the gene encoding the green fluorescent protein, GFP.", "In another type of AAV virus, the AAV contains a pair of inverted terminal repeats (ITRs) which flank at least one cassette containing a promoter which directs cell-specific expression operably linked to a heterologous gene.", "Heterologous in this context refers to any nucleotide sequence or gene which is not native to the AAV or B19 parvovirus.", "Typically, the AAV and B19 coding regions have been deleted, resulting in a safe, non-cytotoxic vector.", "The AAV ITRs or modifications thereof confer infectivity and site-specific integration, but not cytotoxicity, and the promoter directs cell-specific expression.", "U.S. Pat.", "No.", "6,261,834 is herein incorporated by reference for material related to the AAV vector.", "The disclosed vectors thus provide DNA molecules which are capable of integration into a mammalian chromosome without substantial toxicity.", "The inserted genes in viral and retroviral vectors usually contain promoters and/or enhancers to help control the expression of the desired gene product.", "A promoter is generally a sequence or sequences of DNA that function when in a relatively fixed location in regard to the transcription start site.", "A promoter contains core elements required for basic interaction of RNA polymerase and transcription factors, and may contain upstream elements and response elements.", "d. Large Payload Viral Vectors Molecular genetic experiments with large human herpesviruses have provided a means whereby large heterologous DNA fragments can be cloned, propagated, and established in cells permissive for infection with herpesviruses (Sun et al., Nature genetics 8: 33-41, 1994; Cotter and Robertson, Curr Opin Mol Ther 5: 633-644, 1999).", "These large DNA viruses (herpes simplex virus (HSV) and Epstein-Ban virus (EBV)), have the potential to deliver fragments of human heterologous DNA >150 kb to specific cells.", "EBV recombinants can maintain large pieces of DNA in the infected B-cells as episomal DNA.", "Individual clones carrying human genomic inserts up to 330 kb appeared genetically stable.", "The maintenance of these episomes requires a specific EBV nuclear protein, EBNA1, constitutively expressed during infection with EBV.", "Additionally, these vectors can be used for transfection, where large amounts of protein can be generated transiently in vitro.", "Herpesvirus amplicon systems are also being used to package pieces of DNA >220 kb and to infect cells that can stably maintain DNA as episomes.", "Other useful systems include, for example, replicating and host-restricted non-replicating vaccinia virus vectors.", "Nucleic acids that are delivered to cells which are to be integrated into the host cell genome typically contain integration sequences.", "These sequences are often viral-related sequences, particularly when viral-based systems are used.", "These viral intergration systems can also be incorporated into nucleic acids which are to be delivered using a non-nucleic acid-based system of delivery, such as a liposome, so that the nucleic acid contained in the delivery system can become integrated into the host genome.", "Other general techniques for integration into the host genome include, for example, systems designed to promote homologous recombination with the host genome.", "These systems typically rely on sequence flanking the nucleic acid to be expressed that has enough homology with a target sequence within the host cell genome that recombination between the vector nucleic acid and the target nucleic acid takes place, causing the delivered nucleic acid to be integrated into the host genome.", "These systems and the methods necessary to promote homologous recombination are known to those of skill in the art.", "ii.", "Non-Nucleic Acid-Based Systems The disclosed compositions can be delivered to the target cells in a variety of ways.", "For example, the compositions can be delivered through electroporation, through lipofection, or through calcium phosphate precipitation.", "The delivery mechanism chosen will depend, in part, on the type of cell targeted, and whether the delivery is occurring, for example, in vivo or in vitro.", "Thus, the compositions can comprise, in addition to the disclosed nucleic acids, peptides or vectors, for example, lipids such as liposomes, such as cationic liposomes (e.g., DOTMA, DOPE, DC-cholesterol) or anionic liposomes.", "Liposomes can further comprise proteins to facilitate targeting a particular cell, if desired.", "Administration of a composition comprising a compound and a cationic liposome can be administered to the blood afferent to a target organ or inhaled into the respiratory tract to target cells of the respiratory tract.", "Regarding liposomes, see, e.g., Brigham et al.", "Am.", "J. Resp.", "Cell.", "Mol.", "Biol.", "1:95-100 (1989); Feigner et al.", "Proc.", "Natl.", "Acad.", "Sci USA 84:7413-7417 (1987); U.S. Pat.", "No.", "4,897,355.Furthermore, the compound can be administered as a component of a microcapsule that can be targeted to specific cell types, such as macrophages, or where the diffusion of the compound or delivery of the compound from the microcapsule is designed for a specific rate or dosage.", "In the methods described above, which include the administration and uptake of exogenous DNA into the cells of a subject (i.e., gene transduction or transfection), delivery of the compositions to cells can be via a variety of mechanisms.", "As one example, delivery can be via a liposome, using commercially available liposome preparations such as LIPOFECTIN, LIPOFECTAMINE (GIBCO-BRL, Inc., Gaithersburg, Md.", "), SUPERFECT (Qiagen, Inc. Hilden, Germany), and TRANSFECTAM (Promega Biotec, Inc., Madison, Wis.), as well as other liposomes developed according to procedures standard in the art.", "In addition, the disclosed nucleic acid or vector can be delivered in vivo by electroporation, the technology for which is available from Genetronics, Inc. (San Diego, Calif.), as well as by means of a SONOPORATION machine (ImaRx Pharmaceutical Corp., Tucson, Ariz.).", "The materials may be in solution or in suspension (for example, incorporated into microparticles, liposomes, or cells).", "These may be targeted to a particular cell type via antibodies, receptors, or receptor ligands.", "The following references are examples of the use of this technology to target specific proteins to tumor tissue, the principles of which can be applied to targeting of other cells (Senter, et al., Bioconjugate Chem., 2:447-451, (1991); Bagshawe, K. D., Br.", "J.", "Cancer, 60:275-281, (1989); Bagshawe, et al., Br.", "J.", "Cancer, 58:700-703, (1988); Senter, et al., Bioconjugate Chem., 4:3-9, (1993); Battelli, et al., Cancer Immunol.", "Immunother., 35:421-425, (1992); Pietersz and McKenzie, Immunolog.", "Reviews, 129:57-80, (1992); and Roffler, et al., Biochem.", "Pharmacol, 42:2062-2065, (1991)).", "These techniques can be used for a variety of other specific cell types.", "Vehicles such as “stealth” and other antibody-conjugated liposomes (including lipid-mediated drug targeting to colonic carcinoma), receptor-mediated targeting of DNA through cell-specific ligands, lymphocyte-directed tumor targeting, and highly specific therapeutic retroviral targeting of murine glioma cells in vivo.", "The following references are examples of the use of this technology to target specific proteins to tumor tissue (Hughes et al., Cancer Research, 49:6214-6220, (1989); and Litzinger and Huang, Biochimica et Biophysica Acta, 1104:179-187, (1992)).", "In general, receptors are involved in pathways of endocytosis, either constitutive or ligand-induced.", "These receptors cluster in clathrin-coated pits, enter the cell via clathrin-coated vesicles, pass through an acidified endosome in which the receptors are sorted, and then either recycle to the cell surface, become stored intracellularly, or are degraded in lysosomes.", "The internalization pathways serve a variety of functions, such as nutrient uptake, removal of activated proteins, clearance of macromolecules, opportunistic entry of viruses and toxins, dissociation and degradation of ligand, and receptor-level regulation.", "Many receptors follow more than one intracellular pathway, depending on the cell type, receptor concentration, type of ligand, ligand valency, and ligand concentration.", "Molecular and cellular mechanisms of receptor-mediated endocytosis has been reviewed (Brown and Greene, DNA and Cell Biology 10:6, 399-409 (1991)).", "Nucleic acids that are delivered to cells which are to be integrated into the host cell genome typically contain integration sequences.", "These sequences are often viral-related sequences, particularly when viral-based systems are used.", "These viral intergration systems can also be incorporated into nucleic acids which are to be delivered using a non-nucleic acid-based system of delivery, such as a liposome, so that the nucleic acid contained in the delivery system can become integrated into the host genome.", "Other general techniques for integration into the host genome include, for example, systems designed to promote homologous recombination with the host genome.", "These systems typically rely on sequence flanking the nucleic acid to be expressed that has enough homology with a target sequence within the host cell genome that recombination between the vector nucleic acid and the target nucleic acid takes place, causing the delivered nucleic acid to be integrated into the host genome.", "These systems and the methods necessary to promote homologous recombination are known to those of skill in the art.", "7.Expression Systems The nucleic acids that are delivered to cells typically contain expression-controlling systems.", "For example, the inserted genes in viral and retroviral systems usually contain promoters and/or enhancers to help control the expression of the desired gene product.", "A promoter is generally a sequence or sequences of DNA that function(s) when in a relatively fixed location in regard to the transcription start site.", "A promoter contains core elements required for basic interaction of RNA polymerase and transcription factors, and may contain upstream elements and response elements.", "i.", "Viral Promoters and Enhancers Preferred promoters controlling transcription from vectors in mammalian host cells may be obtained from various sources, for example, the genomes of viruses such as: polyoma, Simian Virus 40 (SV40), adenovirus, retroviruses, hepatitis-B virus and, most preferably, cytomegalovirus, or from heterologous mammalian promoters, e.g.", "beta actin promoter.", "The early and late promoters of the SV40 virus are conveniently obtained as an SV40 restriction fragment which also contains the SV40 viral origin of replication (Fiers et al., Nature, 273: 113 (1978)).", "The immediate early promoter of the human cytomegalovirus is conveniently obtained as a HindIII E restriction fragment (Greenway, P. J. et al., Gene 18: 355-360 (1982)).", "Of course, promoters from the host cell or related species also are useful herein.", "Enhancer generally refers to a sequence of DNA that functions at no fixed distance from the transcription start site and can be either 5′ (Laimins, L. et al., Proc.", "Natl.", "Acad.", "Sci.", "78: 993 (1981)) or 3′ (Lusky, M. L., et al., Mol.", "Cell Bio.", "3: 1108 (1983)) to the transcription unit.", "Furthermore, enhancers can be within an intron (Banerji, J. L. et al., Cell 33: 729 (1983)), as well as within the coding sequence itself (Osborne, T. F., et al., Mol.", "Cell Bio.", "4: 1293 (1984)).", "They are usually between 10 and 300 bp in length, and they function in cis Enhancers function to increase transcription from nearby promoters Enhancers also often contain response elements that mediate the regulation of transcription.", "Promoters can also contain response elements that mediate the regulation of transcription Enhancers often determine the regulation of expression of a gene.", "While many enhancer sequences are now known from mammalian genes (globin, elastase, albumin, α-fetoprotein, and insulin), typically, one will use an enhancer from a eukaryotic cell virus for general expression.", "Preferred examples are the SV40 enhancer on the late side of the replication origin (bp 100-270), the cytomegalovirus early promoter enhancer, the polyoma enhancer on the late side of the replication origin, and adenovirus enhancers.", "The promotor and/or enhancer may be specifically activated either by light or specific chemical events which trigger their function.", "Systems can be regulated by reagents such as tetracycline and dexamethasone.", "There are also ways to enhance viral vector gene expression by exposure to irradiation, such as gamma irradiation, or alkylating chemotherapy drugs.", "In certain embodiments, the promoter and/or enhancer region can act as a constitutive promoter and/or enhancer to maximize expression of the region of the transcription unit to be transcribed.", "In certain constructs, the promoter and/or enhancer region is active in all eukaryotic cell types, even if it is only expressed in a particular type of cell at a particular time.", "A preferred promoter of this type is the CMV promoter (650 bases).", "Other preferred promoters are SV40 promoters, cytomegalovirus (full length promoter), and retroviral vector LTR.", "It has been shown that all specific regulatory elements can be cloned and used to construct expression vectors that are selectively expressed in specific cell types, such as melanoma cells.", "The glial fibrillary acetic protein (GFAP) promoter has been used to selectively express genes in cells of glial origin.", "Expression vectors used in eukaryotic host cells (yeast, fungi, insect, plant, animal, human, or nucleated cells) may also contain sequences necessary for the termination of transcription, which may affect mRNA expression.", "These regions are transcribed as polyadenylated segments in the untranslated portion of the mRNA-encoding tissue factor protein.", "The 3′ untranslated regions also include transcription termination sites.", "It is preferred that the transcription unit also contains a polyadenylation region.", "One benefit of this region is that it increases the likelihood that the transcribed unit will be processed and transported like mRNA.", "The identification and use of polyadenylation signals in expression constructs is well established.", "It is preferred that homologous polyadenylation signals be used in the transgene constructs.", "In certain transcription units, the polyadenylation region is derived from the SV40 early polyadenylation signal and consists of about 400 bases.", "It is also preferred that the transcribed units contain other standard sequences alone or in combination with the above sequences to improve expression from, or stability of, the construct.", "ii.", "Markers The viral vectors can include nucleic acid sequence encoding a marker product.", "This marker product is used to determine if the gene has been delivered to the cell and, once delivered, is being expressed.", "Preferred marker genes are the E. coli lacZ gene, which encodes β-galactosidase, and green fluorescent protein.", "In some embodiments, the marker may be a selectable marker.", "Examples of suitable selectable markers for mammalian cells are dihydrofolate reductase (DHFR), thymidine kinase, neomycin, neomycin analog G418, hydromycin, and puromycin.", "When such selectable markers are successfully transferred into a mammalian host cell, the transformed mammalian host cell can survive if placed under selective pressure.", "There are two widely used distinct categories of selective regimes.", "The first category is based on a cell's metabolism and the use of a mutant cell line which lacks the ability to grow independent of supplemented media.", "Two examples are: CHO DHFR− cells and mouse LTK− cells.", "These cells lack the ability to grow without the addition of such nutrients as thymidine or hypoxanthine.", "Because these cells lack certain genes necessary for a complete nucleotide synthesis pathway, they cannot survive unless the missing nucleotides are provided in a supplemented media.", "An alternative to supplementing the media is to introduce an intact DHFR or TK gene into cells lacking the respective genes, thus altering their growth requirements.", "Individual cells which were not transformed with the DHFR or TK gene will not be capable of survival in non-supplemented media.", "The second category is dominant selection, which refers to a selection scheme used in any cell type and does not require the use of a mutant cell line.", "These schemes typically use a drug to arrest growth of a host cell.", "Those cells which have a novel gene would express a protein conveying drug resistance and would survive the selection.", "Examples of such dominant selection use the drugs neomycin, (Southern P. and Berg, P., J. Molec.", "Appl.", "Genet.", "1: 327 (1982)), mycophenolic acid, (Mulligan, R. C. and Berg, P. Science 209: 1422 (1980)), or hygromycin, (Sugden, B. et al., Mol.", "Cell.", "Biol.", "5: 410-413 (1985)).", "The three examples employ bacterial genes under eukaryotic control to convey resistance to the appropriate drug G418 or neomycin (geneticin), xgpt (mycophenolic acid) or hygromycin, respectively.", "Others include the neomycin analog G418 and puramycin.", "8.Internalization Sequences The provided polypeptide can further constitute a fusion protein or otherwise have additional N-terminal, C-terminal, or intermediate amino acid sequences, e.g., linkers or tags.", "“Linker”, as used herein, is an amino acid sequence or insertion that can be used to connect or separate two distinct polypeptides or polypeptide fragments, wherein the linker does not otherwise contribute to the essential function of the composition.", "A polypeptide provided herein can have an amino acid linker comprising, for example, the amino acids GLS, ALS, or LLA.", "A “tag”, as used herein, refers to a distinct amino acid sequence that can be used to detect or purify the provided polypeptide, wherein the tag does not otherwise contribute to the essential function of the composition.", "The provided polypeptide can further have deleted N-terminal, C-terminal, or intermediate amino acids that do not contribute to the essential activity of the polypeptide.", "The disclosed composition can be linked to an internalization sequence or a protein transduction domain to effectively enter the cell.", "Recent studies have identified several cell-penetrating peptides, including the TAT transactivation domain of the HIV virus, antennapedia, and transportan that can readily transport molecules and small peptides across the plasma membrane (Schwarze et al., 1999; Derossi et al., 1996; Yuan et al., 2002).", "More recently, polyarginine has shown an even greater efficiency of transporting peptides and proteins across the plasma membrane, making it an attractive tool for peptide-mediated transport (Fuchs and Raines, 2004).", "Nonaarginine (R9, SEQ ID NO:18) has been described as one of the most efficient polyarginine-based protein transduction domains, with maximal uptake of significantly greater than TAT or antennapeadia.", "Peptide-mediated cytotoxicity has also been shown to be less with polyarginine-based internalization sequences.", "R9-mediated membrane transport is facilitated through heparan sulfate proteoglycan binding and endocytic packaging.", "Once internalized, heparan is degraded by heparanases, releasing R9 which leaks into the cytoplasm (Deshayes et al., 2005).", "Studies have recently shown that derivatives of polyarginine can deliver a full length p53 protein to oral cancer cells, suppressing their growth and metastasis, defining polyarginine as a potent cell penetrating peptide (Takenobu et al., 2002).", "Thus, the provided polypeptide can comprise a cellular internalization transporter or sequence.", "The cellular internalization sequence can be any internalization sequence known or newly discovered in the art or conservative variants thereof.", "Non-limiting examples of cellular internalization transporters and sequences include Polyarginine (e.g., R9), Antennapedia sequences, TAT, HIV-Tat, Penetratin, Antp-3A (Antp mutant), Buforin II, Transportan, MAP (model amphipathic peptide), K-FGF, Ku70, Prion, pVEC, Pep-1, SynB1, Pep-7, HN-1, BGSC (Bis-Guanidinium-Spermidine-Cholesterol, and BGTC (Bis-Guanidinium-Tren-Cholesterol) (see Table 4).", "TABLE 4 Cell Internalization Transporters Name Sequence SEQ ID NO Polyarginine RRRRRRRRR SEQ ID NO: 16 Antp RQPKIWFPNRRKPWKK SEQ ID NO: 17 HIV-Tat GRKKRRQRPPQ SEQ ID NO: 18 Penetratin RQIKIWFQNRRMKWKK SEQ ID NO: 19 Antp-3A RQIAIWFQNRRMKWAA SEQ ID NO: 20 Tat RKKRRQRRR SEQ ID NO: 21 Buforin II TRSSRAGLQFPVGRVHRLLRK SEQ ID NO: 22 Transportan GWTLNSAGYLLGKINKALAALAKKIL SEQ ID NO: 23 model KLALKLALKALKAALKLA SEQ ID NO: 24 amphipathic peptide (MAP) K-FGF AAVALLPAVLLALLAP SEQ ID NO: 25 Ku70 VPMLK-PMLKE SEQ ID NO: 26 Prion MANLGYWLLALFVTMWTDVGLCKKRPKP SEQ ID NO: 27 pVEC LLIILRRRIRKQAHAHSK SEQ ID NO: 28 Pep-1 KETWWETWWTEWSQPKKKRKV SEQ ID NO: 29 SynB1 RGGRLSYSRRRFSTSTGR SEQ ID NO: 30 Pep-7 SDLWEMMMVSLACQY SEQ ID NO: 31 HN-1 TSPLNIHNGQKL SEQ ID NO: 32 BGSC (Bis- Guanidinium- Spermidine- Cholesterol) BGTC (Bis- Guanidinium- Tren- Cholesterol) Any other internalization sequences now known or later identified can be combined with a peptide of the invention.", "9.Effectors The herein provided compositions can further comprise an effector molecule.", "By “effector molecule” is meant a substance that acts upon the target cell(s) or tissue to bring about a desired effect.", "The effect can, for example, be the labeling, activating, repressing, or killing of the target cell(s) or tissue.", "Thus, the effector molecule can, for example, be a small molecule, pharmaceutical drug, toxin, fatty acid, detectable marker, conjugating tag, nanoparticle, or enzyme.", "Examples of small molecules and pharmaceutical drugs that can be conjugated to a targeting peptide are known in the art.", "The effector can be a cytotoxic small molecule or drug that kills the target cell.", "The small molecule or drug can be designed to act on any critical cellular function or pathway.", "For example, the small molecule or drug can inhibit the cell cycle, activate protein degradation, induce apoptosis, modulate kinase activity, or modify cytoskeletal proteins.", "Any known or newly discovered cytotoxic small molecule or drugs is contemplated for use with the targeting peptides.", "The effector can be a toxin that kills the targeted cell.", "Non-limiting examples of toxins include abrin, modeccin, ricin, and diphtheria toxin.", "Other known or newly discovered toxins are contemplated for use with the provided compositions.", "Fatty acids (i.e., lipids) that can be conjugated to the provided compositions include those that allow the efficient incorporation of the peptide into liposomes.", "Generally, the fatty acid is a polar lipid.", "Thus, the fatty acid can be a phospholipid.", "The provided compositions can comprise either natural or synthetic phospholipid.", "The phospholipids can be selected from phospholipids containing saturated or unsaturated mono- or disubstituted fatty acids and combinations thereof.", "These phospholipids can be dioleoylphosphatidylcholine, dioleoylphosphatidylserine, dioleoylphosphatidylethanolamine, dioleoylphosphatidylglycerol, dioleoylphosphatidic acid, palmitoyloleoylphosphatidylcholine, palmitoyloleoylphosphatidylserine, palmitoyloleoylphosphatidylethanolamine, palmitoyloleoylphophatidylglycerol, palmitoyloleoylphosphatidic acid, palmitelaidoyloleoylphosphatidylcholine, palmitelaidoyloleoylphosphatidylserine, palmitelaidoyloleoylphosphatidylethanolamine, palmitelaidoyloleoylphosphatidylglycerol, palmitelaidoyloleoylphosphatidic acid, myristoleoyloleoylphosphatidylcholine, myristoleoyloleoylphosphatidylserine, myristoleoyloleoylphosphatidylethanoamine, myristoleoyloleoylphosphatidylglycerol, myristoleoyloleoylphosphatidic acid, dilinoleoylphosphatidylcholine, dilinoleoylphosphatidylserine, dilinoleoylphosphatidylethanolamine, dilinoleoylphosphatidylglycerol, dilinoleoylphosphatidic acid, palmiticlinoleoylphosphatidylcholine, palmiticlinoleoylphosphatidylserine, palmiticlinoleoylphosphatidylethanolamine, palmiticlinoleoylphosphatidylglycerol, palmiticlinoleoylphosphatidic acid.", "These phospholipids may also be the monoacylated derivatives of phosphatidylcholine (lysophophatidylidylcholine), phosphatidylserine (lysophosphatidylserine), phosphatidylethanolamine (lysophosphatidylethanolamine), phophatidylglycerol (lysophosphatidylglycerol), and phosphatidic acid (lysophosphatidic acid).", "The monoacyl chain in these lysophosphatidyl derivatives may be palimtoyl, oleoyl, palmitoleoyl, linoleoyl myristoyl or myristoleoyl.", "The phospholipids can also be synthetic.", "Synthetic phospholipids are readily available commercially from various sources, such as AVANTI Polar Lipids (Alabaster, Ala.); Sigma Chemical Company (St. Louis, Mo.).", "These synthetic compounds may be varied and may have variations in their fatty acid side chains not found in naturally occurring phospholipids.", "The fatty acid can have unsaturated fatty acid side chains with C14, C16, C18, or C20 chains length in either or both the PS or PC.", "Synthetic phospholipids can have dioleoyl (18:1)-PS; palmitoyl (16:0)-oleoyl (18:1)-PS, dimyristoyl (14:0)-PS; dipalmitoleoyl (16:1)-PC, dipalmitoyl (16:0)-PC, dioleoyl (18:1)-PC, palmitoyl (16:0)-oleoyl (18:1)-PC, and myristoyl (14:0)-oleoyl (18:1)-PC as constituents.", "Thus, as an example, the provided compositions can comprise palmitoyl 16:0.Detectable markers include any substance that can be used to label or stain a target tissue or cell(s).", "Non-limiting examples of detectable markers include radioactive isotopes, enzymes, fluorochromes, and quantum dots (Qdot®).", "Other known or newly discovered detectable markers are contemplated for use with the provided compositions.", "The effector molecule can be a nanoparticle, such as a heat-generating nanoshell.", "As used herein, “nanoshell” is a nanoparticle having a discrete dielectric or semi-conducting core section surrounded by one or more conducting shell layers.", "U.S. Pat.", "No.", "6,530,944 is hereby incorporated by reference herein in its entirety for its teaching of the methods of making and using metal nanoshells.", "Nanoshells can be formed with a core of a dielectric or inert material, such as silicon coated with a material such as a highly conductive metal, which can be excited using radiation such as near infrared light (approximately 800 to 1300 nm).", "Upon excitation, the nanoshells emit heat.", "The resulting hyperthermia can kill the surrounding cell(s) or tissue.", "The combined diameter of the shell and core of the nanoshells ranges from the tens to the hundreds of nanometers.", "Near infrared light is advantageous for its ability to penetrate tissue.", "Other types of radiation can also be used, depending on the selection of the nanoparticle coating and targeted cells.", "Examples include x-rays, magnetic fields, electric fields, and ultrasound.", "The problems with the existing methods for hyperthermia, especially for use in cancer therapy, such as the use of heated probes, microwaves, ultrasound, lasers, perfusion, radiofrequency energy, and radiant heating are avoided, since the levels of radiation used as described herein are insufficient to induce hyperthermia, except at the surface of the nanoparticles where the energy is more effectively concentrated by the metal surface on the dielectric.", "The particles can also be used to enhance imaging, especially using infrared diffuse photon imaging methods.", "Targeting molecules can be antibodies or fragments thereof, ligands for specific receptors, or other proteins specifically binding to the surface of the cells to be targeted.", "The effector molecule can be covalently linked to the disclosed peptide.", "The effector molecule can be linked to the amino-terminal end of the disclosed peptide.", "The effector molecule can be linked to the carboxy-terminal end of the disclosed peptide.", "The effector molecule can be linked to an amino acid within the disclosed peptide.", "The herein-provided compositions can further comprise a linker connecting the effector molecule and disclosed peptide.", "The disclosed peptide can also be conjugated to a coating molecule such as bovine serum albumin (BSA) (see Tkachenko et al., (2003) J Am Chem Soc, 125, 4700-4701) that can be used to coat the Nanoshells with the peptide.", "Protein crosslinkers that can be used to crosslink the effector molecule to the disclosed peptide are known in the art and are defined based on utility and structure and include DSS (Disuccinimidylsuberate), DSP (Dithiobis(succinimidylpropionate)), DTSSP (3,3′-Dithiobis (sulfosuccinimidylpropionate)), SULFO BSOCOES (Bis[2-(sulfosuccinimdooxycarbonyloxy) ethyl]sulfone), BSOCOES (Bis[2-(succinimdooxycarbonyloxy)ethyl]sulfone), SULFO DST (Disulfosuccinimdyltartrate), DST (Disuccinimdyltartrate), SULFO EGS (Ethylene glycolbis(succinimidylsuccinate)), EGS (Ethylene glycolbis(sulfosuccinimidylsuccinate)), DPDPB (1,2-Di[3′-(2′-pyridyldithio) propionamido]butane), BSSS (Bis(sulfosuccinimdyl) suberate), SMPB (Succinimdyl-4-(p-maleimidophenyl) butyrate), SULFO SMPB (Sulfosuccinimdyl-4-(p-maleimidophenyl) butyrate), MBS (3-Maleimidobenzoyl-N-hydroxysuccinimide ester), SULFO MBS (3-Maleimidobenzoyl-N-hydroxysulfosuccinimide ester), SIAB (N-Succinimidyl(4-iodoacetyl) aminobenzoate), SULFO SIAB (N-Sulfosuccinimidyl(4-iodoacetyl)aminobenzoate), SMCC (Succinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate), SULFO SMCC (Sulfosuccinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate), NHS LC SPDP (Succinimidyl-6-[3-(2-pyridyldithio) propionamido) hexanoate), SULFO NHS LC SPDP (Sulfosuccinimidyl-6-[3-(2-pyridyldithio) propionamido) hexanoate), SPDP (N-Succinimdyl-3-(2-pyridyldithio) propionate), NHS BROMOACETATE (N-Hydroxysuccinimidylbromoacetate), NHS IODOACETATE (N-Hydroxysuccinimidyliodoacetate), MPBH (4-(N-Maleimidophenyl) butyric acid hydrazide hydrochloride), MCCH (4-(N-Maleimidomethyl) cyclohexane-1-carboxylic acid hydrazide hydrochloride), MBH (m-Maleimidobenzoic acid hydrazidehydrochloride), SULFO EMCS (N-(epsilon-Maleimidocaproyloxy) sulfosuccinimide), EMCS (N-(epsilon-Maleimidocaproyloxy) succinimide), PMPI (N-(p-Maleimidophenyl) isocyanate), KMUH (N-(kappa-Maleimidoundecanoic acid) hydrazide), LC SMCC (Succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxy(6-amidocaproate)), SULFO GMBS (N-(gamma-Maleimidobutryloxy) sulfosuccinimide ester), SMPH (Succinimidyl-6-(beta-maleimidopropionamidohexanoate)), SULFO KMUS (N-(kappa-Maleimidoundecanoyloxy)sulfosuccinimide ester), GMBS (N-(gamma-Maleimidobutyrloxy) succinimide), DMP (Dimethylpimelimidate hydrochloride), DMS (Dimethylsuberimidate hydrochloride), MHBH (Wood's Reagent) (Methyl-p-hydroxybenzimidate hydrochloride, 98%), DMA (Dimethyladipimidate hydrochloride).", "10.Computer Readable Mediums It is understood that the disclosed nucleic acids and proteins can be represented as a sequence consisting of the nucleotides of amino acids.", "There are a variety of ways to display these sequences; for example, the nucleotide guanosine can be represented by G or g. Likewise, the amino acid valine can be represented by Val or V. Those of skill in the art understand how to display and express any nucleic acid or protein sequence in any of the variety of ways that exist, each of which is considered herein disclosed.", "Specifically contemplated herein is the display of these sequences on computer readable mediums, such as commercially available floppy disks, tapes, chips, hard drives, compact disks, and video disks, or other computer readable mediums.", "Also disclosed are the binary code representations of the disclosed sequences.", "Those of skill in the art understand what computer readable mediums.", "Thus, computer readable mediums on which the nucleic acids or protein sequences are recorded, stored, or saved are disclosed herein.", "Disclosed are computer readable mediums comprising the sequences and information regarding the sequences set forth herein.", "11.Compositions Identified by Screening with Disclosed Compositions/Combinatorial Chemistry The disclosed compositions can be used as targets for any combinatorial technique to identify molecules or macromolecular molecules that interact with the disclosed compositions in a desired way.", "The DR3 and/or TL1A nucleic acids, peptides, and related molecules disclosed herein can be used as targets for the combinatorial approaches.", "Also disclosed are the compositions that are identified through combinatorial techniques or screening techniques, in which the compositions disclosed in SEQ ID NOS:1, 2, 3, or 4 or portions thereof are used as the target in a combinatorial or screening protocol.", "It is understood that when using the disclosed compositions in combinatorial techniques or screening methods, molecules, such as macromolecular molecules, will be identified that have particular desired properties such as inhibition or stimulation or the target molecule's function.", "The molecules identified and isolated when using the disclosed compositions, such as in SEQ ID NOS:1, 2, 3, or 4 or portions thereof, are also disclosed.", "Thus, the products produced using the combinatorial or screening approaches that involve the disclosed compositions, such as in SEQ ID NOS:1, 2, 3, or 4 or portions thereof, are also considered herein disclosed.", "It is understood that the disclosed methods for identifying molecules that inhibit the interactions between, for example, DR3 and TL1A can be performed using high throughput means.", "For example, putative inhibitors can be identified using Fluorescence Resonance Energy Transfer (FRET) to quickly identify interactions.", "The underlying theory of the techniques is that when two molecules are close in space, i.e., interacting at a level beyond background, a signal is produced, or a signal can be quenched.", "Then, a variety of experiments can be performed, including, for example, adding in a putative inhibitor.", "If the inhibitor competes with the interaction between the two signaling molecules, the signals will be removed from each other in space, and this will cause a decrease or an increase in the signal, depending on the type of signal used.", "This decreasing or increasing signal can be correlated to the presence or absence of the putative inhibitor.", "Any signaling means can be used.", "For example, disclosed are methods of identifying an inhibitor of the interaction between any two of the disclosed molecules comprising contacting a first molecule and a second molecule together in the presence of a putative inhibitor, wherein the first molecule or second molecule comprises a fluorescence donor, wherein the first or second molecule, typically the molecule not comprising the donor, comprises a fluorescence acceptor; and measuring Fluorescence Resonance Energy Transfer (FRET) in the presence of the putative inhibitor and the in absence of the putative inhibitor, wherein a decrease in FRET in the presence of the putative inhibitor as compared to FRET measurement in its absence indicates the putative inhibitor inhibits binding between the two molecules.", "This type of method can be performed with a cell system, as well.", "Combinatorial chemistry includes, but is not limited to, all methods for isolating small molecules or macromolecules that are capable of binding either a small molecule or another macromolecule, typically in an iterative process.", "Proteins, oligonucleotides, and sugars are examples of macromolecules.", "For example, oligonucleotide molecules with a given function, catalytic or ligand-binding, can be isolated from a complex mixture of random oligonucleotides in what has been referred to as “in vitro genetics” (Szostak, TIBS 19:89, 1992).", "One synthesizes a large pool of molecules bearing random and defined sequences and subjects that complex mixture, for example, approximately 1015 individual sequences in 100 pg of a 100 nucleotide RNA, to some selection and enrichment process.", "Through repeated cycles of affinity chromatography and PCR amplification of the molecules bound to the ligand on the column, Ellington and Szostak (1990) estimated that 1 in 1010 RNA molecules folded in such a way as to bind a small molecule dye.", "DNA molecules with such ligand-binding behavior have been isolated as well (Ellington and Szostak, 1992; Bock et al., 1992).", "Techniques aimed at similar goals exist for small organic molecules, proteins, antibodies, and other macromolecules known to those of skill in the art.", "Screening sets of molecules for a desired activity, whether based on small organic libraries, oligonucleotides, or antibodies, is broadly referred to as combinatorial chemistry.", "Combinatorial techniques are particularly suited for defining binding interactions between molecules and for isolating molecules that have a specific binding activity, often called aptamers when the macromolecules are nucleic acids.", "12.Carriers The disclosed compositions can be combined, conjugated, or coupled with or to carriers and other compositions to aid administration, delivery, or other aspects of the inhibitors and their use.", "For convenience, such composition will be referred to herein as carriers.", "Carriers can, for example, be a small molecule, pharmaceutical drug, fatty acid, detectable marker, conjugating tag, nanoparticle, or enzyme.", "The disclosed compositions can be used therapeutically in combination with a pharmaceutically acceptable carrier.", "By “pharmaceutically acceptable” is meant a material that is not biologically or otherwise undesirable, i.e., the material can be administered to a subject, along with the composition, without causing any undesirable biological effects or interacting in a deleterious manner with any of the other components of the pharmaceutical composition in which it is contained.", "The carrier would naturally be selected to minimize any degradation of the active ingredient and to minimize any adverse side effects in the subject, as would be well known to one of skill in the art.", "Suitable carriers and their formulations are described in Remington: The Science and Practice of Pharmacy (19th ed.)", "ed.", "A. R. Gennaro, Mack Publishing Company, Easton, Pa. 1995.Typically, an appropriate amount of a pharmaceutically acceptable salt is used in the formulation to render the formulation isotonic.", "Examples of the pharmaceutically acceptable carrier include, but are not limited to, saline, Ringer's solution, and dextrose solution.", "The pH of the solution is preferably from about 5 to about 8, and more preferably from about 7 to about 7.5.Further carriers include sustained release preparations such as semipermeable matrices of solid hydrophobic polymers containing the antibody, which matrices are in the form of shaped articles, e.g., films, liposomes or microparticles.", "It will be apparent to those persons skilled in the art that certain carriers may be more preferable depending upon, for instance, the route of administration and concentration of composition being administered.", "Pharmaceutical carriers are known to those skilled in the art.", "These most typically would be standard carriers for administration of drugs to humans, including solutions such as sterile water, saline, and buffered solutions at physiological pH.", "The compositions can be administered intramuscularly or subcutaneously.", "Other compounds can be administered according to standard procedures used by those skilled in the art.", "Pharmaceutical compositions can include carriers, thickeners, diluents, buffers, preservatives, surface active agents, and the like, in addition to the molecule of choice.", "Pharmaceutical compositions can also include one or more active ingredients, such as antimicrobial agents, antiinflammatory agents, anesthetics, and the like.", "Preparations for parenteral administration include sterile aqueous or non-aqueous solutions, suspensions, and emulsions.", "Examples of non-aqueous solvents are propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable organic esters such as ethyl oleate.", "Aqueous carriers include water, alcoholic/aqueous solutions, emulsions, or suspensions, including saline and buffered media.", "Parenteral vehicles include sodium chloride solution, Ringer's dextrose, dextrose and sodium chloride, lactated Ringer's, or fixed oils.", "Intravenous vehicles include fluid and nutrient replenishers, electrolyte replenishers (such as those based on Ringer's dextrose), and the like.", "Preservatives and other additives can also be present such as, for example, antimicrobials, anti-oxidants, chelating agents, and inert gases and the like.", "Formulations for topical administration can include ointments, lotions, creams, gels, drops, suppositories, sprays, liquids and powders.", "Conventional pharmaceutical carriers, aqueous, powder or oily bases, thickeners and the like may be necessary or desirable.", "Compositions for oral administration include powders or granules, suspensions or solutions in water or non-aqueous media, capsules, sachets, or tablets.", "Thickeners, flavorings, diluents, emulsifiers, dispersing aids, or binders may be desirable.", "Some of the compositions can potentially be administered as a pharmaceutically acceptable acid- or base-addition salt, formed by reaction with inorganic acids such as hydrochloric acid, hydrobromic acid, perchloric acid, nitric acid, thiocyanic acid, sulfuric acid, and phosphoric acid, and organic acids such as formic acid, acetic acid, propionic acid, glycolic acid, lactic acid, pyruvic acid, oxalic acid, malonic acid, succinic acid, maleic acid, and fumaric acid, or by reaction with an inorganic base such as sodium hydroxide, ammonium hydroxide, potassium hydroxide, and organic bases such as mono-, di-, trialkyl and aryl amines, and substituted ethanolamines.", "The materials may be in solution, suspension (for example, incorporated into microparticles, liposomes, or cells).", "These can be targeted to a particular cell type via antibodies, receptors, or receptor ligands.", "The following references are examples of the use of this technology to target specific proteins to tumor tissue (Senter, et al., Bioconjugate Chem., 2:447-451, (1991); Bagshawe, K. D., Br.", "J.", "Cancer, 60:275-281, (1989); Bagshawe, et al., Br.", "J.", "Cancer, 58:700-703, (1988); Senter, et al., Bioconjugate Chem., 4:3-9, (1993); Battelli, et al., Cancer Immunol.", "Immunother., 35:421-425, (1992); Pietersz and McKenzie, Immunolog.", "Reviews, 129:57-80, (1992); and Roffler, et al., Biochem.", "Pharmacol, 42:2062-2065, (1991)).", "Vehicles such as “stealth” and other antibody-conjugated liposomes (including lipid-mediated drug targeting to colonic carcinoma), receptor-mediated targeting of DNA through cell specific ligands, lymphocyte directed tumor targeting, and highly specific therapeutic retroviral targeting of murine glioma cells in vivo.", "The following references are examples of the use of this technology to target specific proteins to tumor tissue (Hughes et al., Cancer Research, 49:6214-6220, (1989); and Litzinger and Huang, Biochimica et Biophysica Acta, 1104:179-187, (1992)).", "In general, receptors are involved in pathways of endocytosis, either constitutive or ligand-induced.", "These receptors cluster in clathrin-coated pits, enter the cell via clathrin-coated vesicles, pass through an acidified endosome in which the receptors are sorted, and then either recycle to the cell surface, become stored intracellularly, or are degraded in lysosomes.", "The internalization pathways serve a variety of functions, such as nutrient uptake, removal of activated proteins, clearance of macromolecules, opportunistic entry of viruses and toxins, dissociation and degradation of ligand, and receptor-level regulation.", "Many receptors follow more than one intracellular pathway, depending on the cell type, receptor concentration, type of ligand, ligand valency, and ligand concentration.", "Molecular and cellular mechanisms of receptor-mediated endocytosis has been reviewed (Brown and Greene, DNA and Cell Biology 10:6, 399-409 (1991)).", "The carrier molecule can be covalently linked to the disclosed inhibitors.", "The carrier molecule can be linked to the amino-terminal end of the disclosed peptides.", "The carrier molecule can be linked to the carboxy-terminal end of the disclosed peptides.", "The carrier molecule can be linked to an amino acid within the disclosed peptides.", "The herein provided compositions can further comprise a linker connecting the carrier molecule and disclosed inhibitors.", "The disclosed inhibitors can also be conjugated to a coating molecule such as bovine serum albumin (BSA) (see Tkachenko et al., (2003) J Am Chem Soc, 125, 4700-4701) that can be used to coat microparticles, nanoparticles of nanoshells with the inhibitors.", "Protein crosslinkers that can be used to crosslink the carrier molecule to the inhibitors, such as the disclosed peptides, are known in the art and are defined based on utility and structure and include DSS (Disuccinimidylsuberate), DSP (Dithiobis(succinimidylpropionate)), DTSSP (3,3′-Dithiobis (sulfosuccinimidylpropionate)), SULFO BSOCOES (Bis[2-(sulfosuccinimdooxycarbonyloxy) ethyl]sulfone), BSOCOES (Bis[2-(succinimdooxycarbonyloxy)ethyl]sulfone), SULFO DST (Disulfosuccinimdyltartrate), DST (Disuccinimdyltartrate), SULFO EGS (Ethylene glycolbis(succinimidylsuccinate)), EGS (Ethylene glycolbis(sulfosuccinimidylsuccinate)), DPDPB (1,2-Di[3′-(2′-pyridyldithio) propionamido]butane), BSSS (Bis(sulfosuccinimdyl) suberate), SMPB (Succinimdyl-4-(p-maleimidophenyl) butyrate), SULFO SMPB (Sulfosuccinimdyl-4-(p-maleimidophenyl) butyrate), MBS (3-Maleimidobenzoyl-N-hydroxysuccinimide ester), SULFO MBS (3-Maleimidobenzoyl-N-hydroxysulfosuccinimide ester), SIAB (N-Succinimidyl(4-iodoacetyl) aminobenzoate), SULFO SIAB (N-Sulfosuccinimidyl(4-iodoacetyl)aminobenzoate), SMCC (Succinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate), SULFO SMCC (Sulfosuccinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate), NHS LC SPDP (Succinimidyl-6-[3-(2-pyridyldithio) propionamido) hexanoate), SULFO NHS LC SPDP (Sulfosuccinimidyl-6-[3-(2-pyridyldithio) propionamido) hexanoate), SPDP (N-Succinimdyl-3-(2-pyridyldithio) propionate), NHS BROMOACETATE (N-Hydroxysuccinimidylbromoacetate), NHS IODOACETATE (N-Hydroxysuccinimidyliodoacetate), MPBH (4-(N-Maleimidophenyl) butyric acid hydrazide hydrochloride), MCCH (4-(N-Maleimidomethyl) cyclohexane-1-carboxylic acid hydrazide hydrochloride), MBH (m-Maleimidobenzoic acid hydrazidehydrochloride), SULFO EMCS (N-(epsilon-Maleimidocaproyloxy) sulfosuccinimide), EMCS (N-(epsilon-Maleimidocaproyloxy) succinimide), PMPI (N-(p-Maleimidophenyl) isocyanate), KMUH (N-(kappa-Maleimidoundecanoic acid) hydrazide), LC SMCC (Succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxy(6-amidocaproate)), SULFO GMBS (N-(gamma-Maleimidobutryloxy) sulfosuccinimide ester), SMPH (Succinimidyl-6-(beta-maleimidopropionamidohexanoate)), SULFO KMUS (N-(kappa-Maleimidoundecanoyloxy)sulfosuccinimide ester), GMBS (N-(gamma-Maleimidobutyrloxy) succinimide), DMP (Dimethylpimelimidate hydrochloride), DMS (Dimethylsuberimidate hydrochloride), MHBH (Wood's Reagent) (Methyl-p-hydroxybenzimidate hydrochloride, 98%), DMA (Dimethyladipimidate hydrochloride).", "i. Nanoparticles, Microparticles, and Microbubbles The term “nanoparticle” refers to a nanoscale particle with a size that is measured in nanometers, for example, a nanoscopic particle that has at least one dimension of less than about 100 nm.", "Examples of nanoparticles include paramagnetic nanoparticles, superparamagnetic nanoparticles, metal nanoparticles, fullerene-like materials, inorganic nanotubes, dendrimers (such as with covalently attached metal chelates), nanofibers, nanohoms, nano-onions, nanorods, nanoropes, and quantum dots.", "A nanoparticle can produce a detectable signal, for example, through absorption and/or emission of photons (including radio frequency and visible photons) and plasmon resonance.", "Microspheres (or microbubbles) can also be used with the methods disclosed herein.", "Microspheres containing chromophores have been utilized in an extensive variety of applications, including photonic crystals, biological labeling, and flow visualization in microfluidic channels.", "See, for example, Y. Lin, et al., Appl.", "Phys Lett.", "2002, 81, 3134; D. Wang, et al., Chem.", "Mater.", "2003, 15, 2724; X. Gao, et al., J. Biomed.", "Opt.", "2002, 7, 532; M. Han, et al., Nature Biotechnology.", "2001, 19, 631; V. M. Pai, et al., Mag.", "& Magnetic Mater.", "1999, 194, 262, each of which is incorporated by reference in its entirety.", "Both the photostability of the chromophores and the monodispersity of the microspheres can be important.", "Nanoparticles such as, for example, silica nanoparticles, metal nanoparticles, metal oxide nanoparticles, or semiconductor nanocrystals can be incorporated into microspheres.", "The optical, magnetic, and electronic properties of the nanoparticles can allow them to be observed while associated with the microspheres and can allow the microspheres to be identified and spatially monitored.", "For example, the high photostability, good fluorescence efficiency, and wide emission tunability of colloidally synthesized semiconductor nanocrystals can make them an excellent choice of chromophore.", "Unlike organic dyes, nanocrystals that emit different colors (i.e.", "different wavelengths) can be excited simultaneously with a single light source.", "Colloidally synthesized semiconductor nanocrystals (such as, for example, core-shell CdSe/ZnS and CdS/ZnS nanocrystals) can be incorporated into microspheres.", "The microspheres can be monodisperse silica microspheres.", "The nanoparticle can be a metal nanoparticle, a metal oxide nanoparticle, or a semiconductor nanocrystal.", "The metal of the metal nanoparticle or the metal oxide nanoparticle can include titanium, zirconium, hafnium, vanadium, niobium, tantalum, chromium, molybdenum, tungsten, manganese, technetium, rhenium, iron, ruthenium, osmium, cobalt, rhodium, iridium, nickel, palladium, platinum, copper, silver, gold, zinc, cadmium, scandium, yttrium, lanthanum, a lanthanide series or actinide series element (e.g., cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, thorium, protactinium, and uranium), boron, aluminum, gallium, indium, thallium, silicon, germanium, tin, lead, antimony, bismuth, polonium, magnesium, calcium, strontium, and barium.", "In certain embodiments, the metal can be iron, ruthenium, cobalt, rhodium, nickel, palladium, platinum, silver, gold, cerium or samarium.", "The metal oxide can be an oxide of any of these materials or combination of materials.", "For example, the metal can be gold, or the metal oxide can be an iron oxide, a cobalt oxide, a zinc oxide, a cerium oxide, or a titanium oxide.", "Preparation of metal and metal oxide nanoparticles is described, for example, in U.S. Pat.", "Nos.", "5,897,945 and 6,759,199, each of which is incorporated by reference in its entirety.", "For example, the disclosed compositions can be immobilized on silica nanoparticles (SNPs).", "SNPs have been widely used for biosensing and catalytic applications owing to their favorable surface area-to-volume ratio, straightforward manufacture and the possibility of attaching fluorescent labels, magnetic nanoparticles (Yang, H. H. et al.", "2005) and semiconducting nanocrystals (Lin, Y. W., et al.", "2006).", "The nanoparticle can also be, for example, a heat-generating nanoshell.", "As used herein, “nanoshell” is a nanoparticle having a discrete dielectric or semi-conducting core section surrounded by one or more conducting shell layers.", "U.S. Pat.", "No.", "6,530,944 is hereby incorporated by reference herein in its entirety for its teaching of the methods of making and using metal nanoshells.", "Targeting molecules can be attached to the disclosed compositions and/or carriers.", "For example, the targeting molecules can be antibodies or fragments thereof, ligands for specific receptors, or other proteins specifically binding to the surface of the cells to be targeted.", "ii.", "Liposomes “Liposome”, as the term is used herein, refers to a structure comprising an outer lipid bi- or multi-layer membrane surrounding an internal aqueous space.", "Liposomes can be used to package any biologically active agent for delivery to cells.", "Materials and procedures for forming liposomes are well-known to those skilled in the art.", "Upon dispersion in an appropriate medium, a wide variety of phospholipids swell, hydrate, and form multilamellar concentric bilayer vesicles with layers of aqueous media separating the lipid bilayers.", "These systems are referred to as multilamellar liposomes or multilamellar lipid vesicles (“MLVs”) and have diameters within the range of 10 nm to 100 μm.", "These MLVs were first described by Bangham, et al., J Mol.", "Biol.", "13:238-252 (1965).", "In general, lipids or lipophilic substances are dissolved in an organic solvent.", "When the solvent is removed, such as under vacuum by rotary evaporation, the lipid residue forms a film on the wall of the container.", "An aqueous solution that typically contains electrolytes or hydrophilic biologically active materials is then added to the film.", "Large MLVs are produced upon agitation.", "When smaller MLVs are desired, the larger vesicles are subjected to sonication, sequential filtration through filters with decreasing pore size, or reduced by other forms of mechanical shearing.", "There are also techniques by which MLVs can be reduced both in size and in number of lamellae, for example, by pressurized extrusion (Barenholz, et al., FEBS Lett.", "99:210-214 (1979)).", "Liposomes can also take the form of unilammelar vesicles, which are prepared by more extensive sonication of MLVs, and consist of a single spherical lipid bilayer surrounding an aqueous solution.", "Unilamellar vesicles (“ULVs”) can be small, having diameters within the range of 20 to 200 nm, while larger ULVs can have diameters within the range of 200 nm to 2 μm.", "There are several well-known techniques for making unilamellar vesicles.", "In Papahadjopoulos, et al., Biochim et Biophys Acta 135:624-238 (1968), sonication of an aqueous dispersion of phospholipids produces small ULVs having a lipid bilayer surrounding an aqueous solution.", "Schneider, U.S. Pat.", "No.", "4,089,801 describes the formation of liposome precursors by ultrasonication, followed by the addition of an aqueous medium containing amphiphilic compounds and centrifugation to form a biomolecular lipid layer system.", "Small ULVs can also be prepared by the ethanol injection technique described by Batzri, et al., Biochim et Biophys Acta 298:1015-1019 (1973) and the ether injection technique of Deamer, et al., Biochim et Biophys Acta 443:629-634 (1976).", "These methods involve the rapid injection of an organic solution of lipids into a buffer solution, which results in the rapid formation of unilamellar liposomes.", "Another technique for making ULVs is taught by Weder, et al.", "in “Liposome Technology”, ed.", "G. Gregoriadis, CRC Press Inc., Boca Raton, Fla., Vol.", "I, Chapter 7, pg.", "79-107 (1984).", "This detergent removal method involves solubilizing the lipids and additives with detergents by agitation or sonication to produce the desired vesicles.", "Papahadjopoulos, et al., U.S. Pat.", "No.", "4,235,871, describes the preparation of large ULVs by a reverse phase evaporation technique that involves the formation of a water-in-oil emulsion of lipids in an organic solvent and the drug to be encapsulated in an aqueous buffer solution.", "The organic solvent is removed under pressure to yield a mixture which, upon agitation or dispersion in an aqueous media, is converted to large ULVs.", "Suzuki et al., U.S. Pat.", "No.", "4,016,100, describes another method of encapsulating agents in unilamellar vesicles by freezing/thawing an aqueous phospholipid dispersion of the agent and lipids.", "In addition to the MLVs and ULVs, liposomes can also be multivesicular.", "Described in Kim, et al., Biochim et Biophys Acta 728:339-348 (1983), these multivesicular liposomes are spherical and contain internal granular structures.", "The outer membrane is a lipid bilayer, and the internal region contains small compartments separated by bilayer septum.", "Still yet another type of liposomes are oligolamellar vesicles (“OLVs”), which have a large center compartment surrounded by several peripheral lipid layers.", "These vesicles, having a diameter of 2-15 μm, are described in Callo, et al., Cryobiology 22(3):251-267 (1985).", "Mezei, et al., U.S. Pat.", "Nos.", "4,485,054 and 4,761,288, also describe methods of preparing lipid vesicles.", "More recently, Hsu, U.S. Pat.", "No.", "5,653,996, describes a method of preparing liposomes utilizing aerosolization, and Yiournas, et al., U.S. Pat.", "No.", "5,013,497, describes a method for preparing liposomes utilizing a high velocity-shear mixing chamber.", "Methods are also described that use specific starting materials to produce ULVs (Wallach, et al., U.S. Pat.", "No.", "4,853,228) or OLVs (Wallach, U.S. Pat.", "Nos.", "5,474,848 and 5,628,936).", "A comprehensive review of all of the aforementioned lipid vesicles and methods for their preparation are described in “Liposome Technology”, ed.", "G. Gregoriadis, CRC Press Inc., Boca Raton, Fla., Vol.", "I, II & III (1984).", "This and the aforementioned references describing various lipid vesicles suitable for use in the invention are incorporated herein by reference.", "Fatty acids (i.e., lipids) that can be conjugated to the provided compositions include those that allow the efficient incorporation of the proprotein convertase inhibitors into liposomes.", "Generally, the fatty acid is a polar lipid.", "Thus, the fatty acid can be a phospholipid.", "The provided compositions can comprise either natural or synthetic phospholipid.", "The phospholipids can be selected from phospholipids containing saturated or unsaturated mono- or di-substituted fatty acids and combinations thereof.", "These phospholipids can be dioleoylphosphatidylcholine, dioleoylphosphatidylserine, dioleoylphosphatidylethanolamine, dioleoylphosphatidylglycerol, dioleoylphosphatidic acid, palmitoyloleoylphosphatidylcholine, palmitoyloleoylphosphatidylserine, palmitoyloleoylphosphatidylethanolamine, palmitoyloleoylphophatidylglycerol, palmitoyloleoylphosphatidic acid, palmitelaidoyloleoylphosphatidylcholine, palmitelaidoyloleoylphosphatidylserine, palmitelaidoyloleoylphosphatidylethanolamine, palmitelaidoyloleoylphosphatidylglycerol, palmitelaidoyloleoylphosphatidic acid, myristoleoyloleoylphosphatidylcholine, myristoleoyloleoylphosphatidylserine, myristoleoyloleoylphosphatidylethanoamine, myristoleoyloleoylphosphatidylglycerol, myristoleoyloleoylphosphatidic acid, dilinoleoylphosphatidylcholine, dilinoleoylphosphatidylserine, dilinoleoylphosphatidylethanolamine, dilinoleoylphosphatidylglycerol, dilinoleoylphosphatidic acid, palmiticlinoleoylphosphatidylcholine, palmiticlinoleoylphosphatidylserine, palmiticlinoleoylphosphatidylethanolamine, palmiticlinoleoylphosphatidylglycerol, palmiticlinoleoylphosphatidic acid.", "These phospholipids may also be the monoacylated derivatives of phosphatidylcholine (lysophophatidylidylcholine), phosphatidylserine (lysophosphatidylserine), phosphatidylethanolamine (lysophosphatidylethanolamine), phophatidylglycerol (lysophosphatidylglycerol), and phosphatidic acid (lysophosphatidic acid).", "The monoacyl chain in these lysophosphatidyl derivatives may be palimtoyl, oleoyl, palmitoleoyl, linoleoyl myristoyl, or myristoleoyl.", "The phospholipids can also be synthetic.", "Synthetic phospholipids are readily available commercially from various sources, such as AVANTI Polar Lipids (Alabaster, Ala.); Sigma Chemical Company (St. Louis, Mo.).", "These synthetic compounds may be varied and may have variations in their fatty acid side chains not found in naturally occurring phospholipids.", "The fatty acid can have unsaturated fatty acid side chains with C14, C16, C18, or C20 chains length in either or both the PS or PC.", "Synthetic phospholipids can have dioleoyl (18:1)-PS; palmitoyl (16:0)-oleoyl (18:1)-PS, dimyristoyl (14:0)-PS; dipalmitoleoyl (16:1)-PC, dipalmitoyl (16:0)-PC, dioleoyl (18:1)-PC, palmitoyl (16:0)-oleoyl (18:1)-PC, and myristoyl (14:0)-oleoyl (18:1)-PC as constituents.", "Thus, as an example, the provided compositions can comprise palmitoyl 16:0.iii.", "In Vivo/Ex Vivo As described above, the compositions can be administered in a pharmaceutically acceptable carrier and can be delivered to the subject's cells in vivo and/or ex vivo by a variety of mechanisms well known in the art (e.g., uptake of naked DNA, liposome fusion, intramuscular injection of DNA via a gene gun, endocytosis, and the like).", "If ex vivo methods are employed, cells or tissues can be removed and maintained outside the body according to standard protocols well known in the art.", "The compositions can be introduced into the cells via any gene transfer mechanism, such as, for example, calcium phosphate-mediated gene delivery, electroporation, microinjection, or proteoliposomes.", "The transduced cells can then be infused (e.g., in a pharmaceutically acceptable carrier) or homotopically transplanted back into the subject per standard methods for the cell or tissue type.", "Standard methods are known for transplantation or infusion of various cells into a subject.", "C. Methods of Making the Compositions The compositions disclosed herein and the compositions necessary to perform the disclosed methods can be made using any method known to those of skill in the art for that particular reagent or compound unless otherwise specifically noted.", "1.Nucleic Acid Synthesis A polynucleotide comprising naturally occurring nucleotides and phosphodiester bonds can be chemically synthesized or can be produced using recombinant DNA methods, using an appropriate polynucleotide as a template.", "In comparison, a polynucleotide comprising nucleotide analogs or covalent bonds other than phosphodiester bonds generally will be chemically synthesized, although an enzyme such as T7 polymerase can incorporate certain types of nucleotide analogs into a polynucleotide and, therefore, can be used to produce such a polynucleotide recombinantly from an appropriate template (Jellinek et al., Biochemistry 34:11363-11372 (1995)).", "For example, the nucleic acids, such as the oligonucleotides to be used as primers, can be made using standard chemical synthesis methods or can be produced using enzymatic methods or any other known method.", "Such methods can range from standard enzymatic digestion followed by nucleotide fragment isolation (see for example, Sambrook et al., Molecular Cloning: A Laboratory Manual, 2nd Edition (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989) Chapters 5, 6) to purely synthetic methods, for example, by the cyanoethyl phosphoramidite method using a Milligen or Beckman System 1Plus DNA synthesizer (for example, Model 8700 automated synthesizer of Milligen-Biosearch, Burlington, Mass.", "or ABI Model 380B).", "Synthetic methods useful for making oligonucleotides are also described by Ikuta et al., Ann.", "Rev.", "Biochem.", "53:323-356 (1984), (phosphotriester and phosphite-triester methods), and Narang et al., Methods Enzymol., 65:610-620 (1980), (phosphotriester method).", "Protein nucleic acid molecules can be made using known methods such as those described by Nielsen et al., Bioconjug.", "Chem.", "5:3-7 (1994).", "2.Peptide Synthesis One method of producing the disclosed proteins, such as SEQ ID NO:23, is to link two or more peptides or polypeptides together by protein chemistry techniques.", "For example, peptides or polypeptides can be chemically synthesized using currently available laboratory equipment using either Fmoc (9-fluorenylmethyloxycarbonyl) or Boc (tert-butyloxycarbonoyl) chemistry (Applied Biosystems, Inc., Foster City, Calif.).", "One skilled in the art can readily appreciate that a peptide or polypeptide corresponding to the disclosed proteins, for example, can be synthesized by standard chemical reactions.", "For example, a peptide or polypeptide can be synthesized and not cleaved from its synthesis resin, whereas the other fragment of a peptide or protein can be synthesized and subsequently cleaved from the resin, thereby exposing a terminal group, which is functionally blocked on the other fragment.", "By peptide condensation reactions, these two fragments can be covalently joined via a peptide bond at their carboxyl and amino termini, respectively, to form an antibody or fragment thereof.", "(Grant G A (1992) Synthetic Peptides: A User Guide.", "W.H.", "Freeman and Co., N.Y. (1992); Bodansky M and Trost B., Ed.", "(1993) Principles of Peptide Synthesis.", "Springer-Verlag Inc., NY, which is herein incorporated by reference at least for material related to peptide synthesis.", "Alternatively, the peptide or polypeptide is independently synthesized in vivo as described herein.", "Once isolated, these independent peptides or polypeptides may be linked to form a peptide or fragment thereof via similar peptide condensation reactions.", "For example, enzymatic ligation of cloned or synthetic peptide segments allows relatively short peptide fragments to be joined to produce larger peptide fragments, polypeptides, or whole protein domains (Abrahmsen L et al., Biochemistry, 30:4151 (1991)).", "Alternatively, native chemical ligation of synthetic peptides can be utilized to synthetically construct large peptides or polypeptides from shorter peptide fragments.", "This method consists of a two-step chemical reaction (Dawson et al.", "Synthesis of Proteins by Native Chemical Ligation.", "Science, 266:776-779 (1994)).", "The first step is the chemoselective reaction of an unprotected synthetic peptide-thioester with another unprotected peptide segment containing an amino-terminal Cys residue to give a thioester-linked intermediate as the initial covalent product.", "Without a change in the reaction conditions, this intermediate undergoes spontaneous, rapid intramolecular reaction to form a native peptide bond at the ligation site (Baggiolini M et al.", "(1992) FEBS Lett.", "307:97-101; Clark-Lewis I et al., J. Biol.", "Chem., 269:16075 (1994); Clark-Lewis I et al., Biochemistry, 30:3128 (1991); Rajarathnam K et al., Biochemistry 33:6623-30 (1994)).", "Alternatively, unprotected peptide segments are chemically linked where the bond formed between the peptide segments as a result of the chemical ligation is an unnatural (non-peptide) bond (Schnolzer, M et al.", "Science, 256:221 (1992)).", "This technique has been used to synthesize analogs of protein domains, as well as large amounts of relatively pure proteins with full biological activity (deLisle Milton R C et al., Techniques in Protein Chemistry IV.", "Academic Press, New York, pp.", "257-267 (1992)).", "D. Kits The materials described above, as well as other materials, can be packaged together in any suitable combination as a kit useful for performing, or aiding in the performance of, the disclosed method.", "It is useful if the kit components in a given kit are designed and adapted for use together in the disclosed method.", "For example, disclosed are kits comprising peptides or antibodies that bind DR3 or TL1A.", "E. Uses The disclosed compositions can be used in a variety of ways as research tools.", "For example, the disclosed compositions, such as an isolated polypeptide comprising SEQ ID NOs:2 or 4, can be used to study the interactions between DR3 or TL1A by, for example, acting as inhibitors of binding.", "Other uses are disclosed, apparent from the disclosure, and/or will be understood by those in the art.", "Other uses are disclosed, apparent from the disclosure, and/or will be understood by those in the art.", "F. Definitions Unless defined otherwise, all technical and scientific terms used herein have the same meanings as commonly understood by one of skill in the art to which the disclosed method and compositions belong.", "Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present method and compositions, the particularly useful methods, devices, and materials are as described.", "Publications cited herein and the material for which they are cited are hereby specifically incorporated by reference.", "Nothing herein is to be construed as an admission that the present invention is not entitled to antedate such disclosure by virtue of prior invention.", "No admission is made that any reference constitutes prior art.", "The discussion of references states what their authors assert, and applicants reserve the right to challenge the accuracy and pertinency of the cited documents.", "It must be noted that, as used herein and in the appended claims, the singular forms “a,” “an,” and “the” include plural reference unless the context clearly dictates otherwise.", "Thus, for example, reference to “a pharmaceutical carrier” includes a plurality of such pharmaceutical carriers, reference to “the pharmaceutical carrier” is a reference to one or more pharmaceutical carriers and equivalents thereof known to those skilled in the art, and so forth.", "“Optional” or “optionally” means that the subsequently described event, circumstance, or material may or may not occur or be present, and that the description includes instances where the event, circumstance, or material occurs or is present and instances where it does not occur or is not present.", "Ranges can be expressed herein as from “about” one particular value and/or to “about” another particular value.", "When such a range is expressed, another embodiment includes from the one particular value and/or to the other particular value.", "Similarly, when values are expressed as approximations, by use of the antecedent “about,” it will be understood that the particular value forms another embodiment.", "It will be further understood that the endpoints of each of the ranges are significant both in relation to the other endpoint, and independently of the other endpoint.", "It is also understood that there are a number of values disclosed herein, and that each value is also herein disclosed as “about” that particular value in addition to the value itself.", "For example, if the value “10” is disclosed, then “about 10” is also disclosed.", "It is also understood that when a value is disclosed, “less than or equal to” the value, “greater than or equal to the value” and possible ranges between values are also disclosed, as appropriately understood by the skilled artisan.", "For example, if the value “10” is disclosed, “less than or equal to 10,” as well as “greater than or equal to 10,” are also disclosed.", "It is also understood that throughout the application, data is provided in a number of different formats, and that this data represents endpoints and starting points, and ranges for any combination of the data points.", "For example, if a particular data point “10” and a particular data point “15” are disclosed, it is understood that greater than, greater than or equal to, less than, less than or equal to, and equal to 10 and 15 are considered disclosed, as well as between 10 and 15.It is also understood that each unit between two particular units is also disclosed.", "For example, if 10 and 15 are disclosed, then 11, 12, 13, and 14 are also disclosed.", "Throughout the description and claims of this specification, the word “comprise” and variations of the word, such as “comprising” and “comprises,” means “including but not limited to,” and is not intended to exclude, for example, other additives, components, integers, or steps.", "“Probes” are molecules capable of interacting with a target nucleic acid, typically in a sequence-specific manner, for example through hybridization.", "The hybridization of nucleic acids is well understood in the art and discussed herein.", "Typically, a probe can be made from any combination of nucleotides or nucleotide derivatives or analogs available in the art.", "“Primers” are a subset of probes which are capable of supporting some type of enzymatic manipulation, and which can hybridize with a target nucleic acid such that the enzymatic manipulation can occur.", "A primer can be made from any combination of nucleotides or nucleotide derivatives or analogs available in the art which do not interfere with the enzymatic manipulation.", "Typically, a primer supports extension of a polynucleotide sequence.", "“Subject” includes, but is not limited to, animals, plants, bacteria, viruses, parasites and any other organism or entity that has nucleic acid.", "The subject may be a vertebrate, more specifically a mammal (e.g., a human, horse, pig, rabbit, dog, sheep, goat, non-human primate, cow, cat, guinea pig, or rodent), a fish, a bird, a reptile, or an amphibian.", "The subject may be an invertebrate, more specifically an arthropod (e.g., insects and crustaceans).", "The term does not denote a particular age or sex.", "Thus, adult and newborn subjects, as well as fetuses, whether male or female, are intended to be covered.", "A patient refers to a subject afflicted with a disease or disorder.", "The term “patient” includes human and veterinary subjects.", "As defined herein, “sample” refers to any sample obtained from an organism.", "Examples of biological samples include body fluids and tissue specimens.", "The source of the sample may be physiological media as blood, serum, plasma, breast milk, pus, tissue scrapings, washings, urine, feces, tears, lymph, bile, cerebrospinal fluid, interstitial fluid, aqueous or vitreous humor, colostrum, sputum, amniotic fluid, saliva, anal and vaginal secretions, perspiration, semen, transudate, exudate, and synovial fluid, and tissues, such as lymph nodes, spleen or the like.", "As used herein, “blocked” can mean complete or partial inhibition of an interaction, for example, the interaction (e.g., binding) between a ligand and its receptor.", "Inhibited binding can be detected through measurement of the normal downstream effect of normal binding.", "As used herein, “treatment” or “treating” means to administer a composition to a subject with a condition, wherein the condition can be any pathologic disease, cancer, or inflammatory condition.", "The effect of the administration to the subject can be, but is not limited to, reducing the symptoms of the condition, a reduction in the severity of the condition, or the complete cessation of the condition.", "By “prevent” is meant to minimize the chance that a subject who has a predisposition for developing a disease or condition involving the interaction of TL1A with DR3 (e.g., an autoimmune disease with a T cell component) will develop the disease or condition.", "Throughout this application, various publications are referenced.", "The disclosures of these publications in their entireties are hereby incorporated by reference into this application in order to more fully describe the state of the art to which this pertains.", "The references disclosed are also individually and specifically incorporated by reference herein for the material contained in them that is discussed in the sentence in which the reference is relied upon.", "G. EXAMPLES The following examples are put forth so as to provide those of ordinary skill in the art with a complete disclosure and description of how the compounds, compositions, articles, devices, and/or methods claimed herein are made and evaluated, and are intended to be purely exemplary and are not intended to limit the disclosure.", "Efforts have been made to ensure accuracy with respect to numbers (e.g., amounts, temperature, etc.", "), but some errors and deviations should be accounted for.", "Unless indicated otherwise, parts are parts by weight, temperature is in ° C. or is at ambient temperature, and pressure is at or near atmospheric.", "Example 1 In addition to endothelial cells, TL1A is rapidly upregulated and secreted from dendritic cells after stimulation through TLR4 or TRL11 in a myd88-dependent manner, and is also inducible by activated T cells in part through CD40L-CD40 interactions.", "T cells themselves upregulate TL1A after activation with delayed kinetics.", "Exogenous and endogenous TL1A can costimulate naïve T cell proliferation and cytokine production through DR3.Cytokine production by differentiated effector cells is inefficient in DR3-deficient T cells but can be largely overcome by strong stimuli or the presence of dendritic cells.", "In vivo, DR3-deficient mice display defects in T cell-dependent immunopathology in EAE and asthma models, but systemic T cell polarization and effector function are preserved.", "DR3 thus functions as a specific potentiator of cytokine production and immunopathology in inflamed tissues and, as such, presents a target for therapy of T-cell mediated autoimmune disease Myeloid DC produce soluble TL1A rapidly following both innate immune stimuli in a TLR- and Myd88-dependent fashion, whereas T cells produce lower amounts of TL1A more slowly, and T cell-derived TL1A is not shed into the supernatant.", "It was determined that TL1A added exogenously or produced by DC, but not T cells alone, can costimulate naïve T cell proliferation and cytokine production.", "Differentiation into Th1 and Th2 effector cells is not dependent on DR3, although the efficiency of cytokine production under sub-optimal conditions is affected.", "In vivo, DR3-deficient T cells differentiate into effector cells, which can produce cytokines in the spleen and lymph nodes.", "However, DR3-deficient mice are resistant to two distinct models of T cell-dependent autoimmunity, with reduced production of effector cytokines at the site of inflammation.", "TL1A-DR3 interactions, thus, potentiate effector T cell function in target tissues, contributing to T-cell mediated immunopathology.", "a.", "Differential Induction of TL1A in T Cells and Dendritic Cells When human peripheral blood mononuclear cells (PBMC) were activated with antibodies against the T cell receptor, a rapid and dramatic upregulation of TL1A mRNA occurred, peaking at 6 hours with ˜1000-fold induction (FIG.", "1D).", "However, when T and B cells were purified from peripheral blood and activated in isolation, TL1A upregulation was much slower, peaking at 48 hours with less than 100-fold induction.", "This indicates that non-lymphocyte antigen-presenting cells may be the major source of TL1A for T cells during initial activation.", "In purified murine splenic and bone marrow-derived CD11c+ DC, TL1A mRNA was rapidly upregulated by LPS, peaking at 3 hours and returning to baseline by 12 hours (FIG.", "1A).", "To explore the stimuli that induce TL1A in more detail, the parasite-derived immunostimulatory molecules tachyzoite Antigen from Toxoplasma gondii (STAg) and Schistosoma Egg Antigen from Schistosoma mansoni (SEA) were used, which led to differential DC activation programs that prime T cells for Th1 and Th2 responses, respectively.", "Dendritic cells stimulated with STAg but not with SEA strongly upregulated TL1A mRNA with similar kinetics to LPS (FIG.", "1A, right panel).", "Even after up to 24 hours, SEA did not induce TL1A (lower panel).", "Experiments with DC from various knockout mice showed that TL1A induction was dependent on Myd88 and TIRAP, and LPS induction of TL1A was TLR4-dependent (FIG.", "1B).", "When highly purified mouse T cells were activated through the TCR, similar TL1A upregulation was observed with delayed kinetics seen in human T cells (FIG.", "1C).", "These data show that, like other TNF-family members, TL1A can be acutely upregulated in DC through TLRs and the Myd88/TIRAP-dependent signaling pathway.", "DC-derived TL1A would be available to modulate the initial phases of T cell activation, whereas T cells upregulate TL1A more slowly, where it may influence later steps in T cell expansion and differentiation.", "b. TL1A Costimulates Proliferation and Cytokine Production in CD4+ T Cells Through DR3.Exogenous TL1A has previously been shown to costimulate T cells, but whether this is dependent on DR3, and what role endogenously produced TL1A plays in mature T cell activation, has not been investigated.", "To investigate this, CD4+ T cells were purified from spleens and lymph nodes of wild-type (WT) C567Bl/6 or isogenic DR3 knockout (KO) mice and activated in the presence or absence of recombinant murine TL1A.", "Costimulation by other TNF family members has been shown to be maximal when CD28-mediated costimulation is blocked (Croft, 2003).", "Exogenously added TL1A consistently increased T cell proliferation, and this effect was more apparent in the absence of CD28-mediated costimulation (FIG.", "2A).", "With dual CD3/CD28 crosslinking, TL1A only costimulated proliferation at lower doses of anti-CD3.Importantly, DR3 KO cells were completely unresponsive to TL1A, indicating that DR3 is the major receptor that mediates costimulation by TL1A.", "Also, similar to their previously reported normal proliferation in response to ConA (Wang et al., 2001), purified T cells from WT and DR3 KO mice proliferated similarly in response to anti-CD3 with or without costimulation (FIG.", "2A).", "To determine if the increased thymidine incorporation triggered by TL1A was due to increased cell cycling versus effects on cell survival, CFSE dilution experiments were performed under similar conditions.", "In accordance with the thymidine incorporation data, exogenous TL1A significantly increased CFSE dilution, reflecting increased cell cycling, especially in the absence of CD28 signaling (FIG.", "2B).", "No changes in cell viability in response to TL1A were detected in these experiments.", "To investigate the spectrum of cytokines that can be costimulated by TL1A and the dependence of cytokine production on DR3, IL-2, interferon-γ (IFN-γ), and IL-4 production were measured in WT or DR3 KO T cells activated in the presence or absence of recombinant TL1A.", "TL1A increased IL-2 production, interferon-γ production, and IL-4 production by WT, but not DR3 KO, cells activated with or without CD28.IL-4 was the cytokine most prominently induced by TL1A, increasing by approximately 10-fold, whereas IL-2 and interferon-γ increased less than two-fold (FIG.", "2D).", "DR3-deficient T cells were unresponsive to TL1A, but had no defect in cytokine production.", "Thus, as with proliferative responses, DR3 is the major mediator of TL1A signaling, and endogenously produced T cell-derived TL1A is not necessary for cytokine production by activated T cells under these conditions.", "To determine if TL1A-driven proliferation is due to increased IL-2 production, an anti-CD25 blocking antibody was added during T cell activation in the presence or absence of TL1A.", "CD25 blockade blocked most of the increased proliferation induced by TL1A, but some IL-2-independent proliferation could still be seen, indicating that TL1A-driven costimulation is at least partly dependent on increased production of IL-2 (FIG.", "2B).", "Since purified DR3-deficient T cells did not have major defects in proliferative responses or cytokine production, the TL1A produced by T cells did not seem to be essential for these functions.", "Thus, the TL1A produced by dendritic cells during cognate DC-T cell interactions may be the more relevant source of TL1A for T cell costimulation.", "To test this, experiments with DR3 WT or KO mice crossed to the Ovalbumin (Ova)-specific TCR transgenic line OT-II were performed.", "Purified DR-3-deficient cells were co-cultured with C57Bl/6 bone marrow-derived DC and the cognate Ova peptide.", "Under these conditions, proliferation of DR3 KO cells was diminished especially in the presence of low concentration of Ova peptide (FIG.", "3A) with or without CTLA4-Ig blockade.", "Cytokine production by OT-II T cells is characteristically dependent on the dose of antigen, with higher doses favoring IFN-γ production and lower doses favoring IL-4 production.", "DR3 KO OT-II cells produced approximately 50% lower IL-2 at lower doses of Ova and lower amounts of IL-4 at all doses of Ova tested (FIG.", "3B).", "Thus, endogenous TL1A produced by dendritic cells is likely to be a physiologically important source of this costimulatory TNF family member.", "c. DR3 KO T Cells have a Reduced Th2 Differentiation when Polarized In Vitro.", "To investigate the consequences of TL1A-DR3 interactions for later steps in T cell differentiation, DR3-deficient T cells were tested for effector cytokine production in two types of T cell polarization assays.", "Purified T cells from WT or DR3 KO mice were activated with either IL-4 and anti-IFN-γ for Th2 polarization or IL-12 and anti-IL-4 for Th1 polarization.", "When purified T cells were re-stimulated after 5-6 days of activation and polarization, there were significant defects in the percentages of cells producing IFN-γ and IL-4, when T cells were re-stimulated through the TCR.", "However, the combination of PMA/ionomycin allowed normal production of these cytokines (FIG.", "4A).", "Interestingly, IL-17 production by polarized T cells polarized to this effector type by a combination of TGF beta, IL-1, IL-6, TNF, and blockade of IL-4 and IL-12 was defective in supernatants 72 hours after primary activation and after re-stimulation with CD3/CD28.Since PMA/ionomycin stimulation appeared to bypass the cytokine secretion defect, the defect in DR3 KO cells may be more in TCR-induced cytokine secretion rather than T cell differentiation itself.", "To determine whether T cell differentiation was intact in the absence of DR3, the levels of T-bet and GATA-3, the canonical transcription factors that program Th1 and Th2 T cell differentiation, respectively, were measured.", "As shown in FIG.", "4B, induction of T-bet in DR3 KO T cells polarized to differentiate into Th1 cells was normal, and GATA-3 induction under Th2 conditions was only slightly impaired.", "Thus, it appeared that DR3 is more important in cytokine production than in programming T cells for differentiation into a particular T cell subset.", "To determine if this was also the case when TL1A was provided by dendritic cells, T cells from DR3 KO×OT-II mice or OT-II controls were cultured with antigen and DC under conditions in which polarization is driven by exogenous cytokines or endogenous factors produced under the influence of the parasite-derived antigens SEA or STag.", "No defects in IFN-γ were found when DR3 KO T cells were polarized with Stag or exogenous IL-12 and anti-IL4 (FIG.", "4D).", "However, a significant defect in IL-4 production was seen in T cells activated in the presence of SEA.", "This was overcome by addition of exogenous IL-4.Unlike STAg-induced Th1 polarization that does not require T cell-derived IFN-γ, Th2 polarization by SEA is known to be dependent on T cell-derived IL-4.Thus, the defect in IL-4 production by DR3 KO T cells that was observed (FIG.", "3B) may account for the Th2 polarization defect in the absence of exogenous IL-4.d.", "DR3 KO Mice have Reduced Lung Inflammation in an Ova-Induced Asthma Model To determine whether the Th2 polarization defect in vitro was significant in an animal model of a Th2-mediated disease, how DR3 KO mice would respond in an Ova-dependent asthma model was investigated.", "Mice were sensitized with Alum and Ova protein or Alum and PBS as a control and then challenged intratracheally and intranasally with either Ova protein or PBS.", "The mice were sacrificed two days after the last challenge.", "The histology showed that the DR3 KO mice lungs had less mucin production than the WT mice, and also less peribroncheal cuffing (FIG.", "5A).", "The histopathology score for the DR3 KO lungs was also reduced compare to the WT lungs (FIG.", "5B).", "In addition, the inflammation in the DR3 KO lungs was predominantly lymphocytic in the DR3 KO versus the typical eosinophilic infiltrates in the WT lungs.", "Next, the mRNA levels of different cytokines in the lung were determined.", "DR3 KO lungs have reduced IL-13, a reflection of the mucus production, and IL-5 in the lungs compared to the WT lungs (FIG.", "5C).", "In addition, whether the Ova-specific restimulation of the spleen was affected was determined.", "Interestingly, in contrast to the cytokine mRNA level observed in the lung, there were no differences in cytokine production, suggesting a more local effect.", "In addition, there was no difference between the WT and DR3 KO mice T cell proliferation.", "The level of IgG1 present in the serum was also determined.", "There was no difference in IgG1, IgG2 sera level between WT and DR3 KO mice, especially in the Ova-specific IgG1 (FIG.", "5D) level, suggesting a more local effect of the differences in the pathology.", "The fact that the IgG1 production was elevated after the Ova challenge in the DR3 KO mice compared to PBS-treated mice indicates that the T cells were able to respond and differentiate, even if it is to a lesser extent (data from in vitro polarization).", "Thus, the decrease in local inflammation may be due to a defect in a late stage of the immune response.", "e. DR3 KO Mice are Less Susceptible to EAE.", "As the DR3 KO mice have a decrease in Th2Th2 T cell-mediated pathology in the asthma model, correlating with a decrease in in vitro Th2 differentiation, how DR3 KO mice would respond to a Th1/Th17-mediated disease was investigated.", "To this end, a MOG (myelin oligodendrocyte glycoprotein)-induced EAE mouse model was used.", "DR3 KO mice have a delayed and reduced EAE pathology compared to WT mice that develop clinical pathology about one week after MOG injection (FIG.", "6A).", "This indicates that DR3 KO mice have reduced pathology in disease models that are dependent on entirely different cytokines.", "In addition, similar to the Ova-asthma model, the MOG-restimulation of the T cells from the spleen and the lymph nodes was not impaired (FIG.", "6B).", "This again indicates that the overall effect of the DR3/TL1A defect seemed to be more local than systemic.", "Several recent reports indicate that additional subsets of effector T cells such as IL-17 producing cells are produced during immune responses.", "This population of IL-17 producing cells was thought to be responsible for the pathogenicity in Th1-mediated diseases rather than effector cells producing Th1 cytokines.", "Thus, to determine to what extent the IL-17 producing cells were present in the brain, spleen, and lymph nodes, hematopoietic cells were taken from the spinal cord and stimulated for 6 hours with PMA/ionomycin before intracellular staining for IL-17 and IFN-γ.", "Decreased IL-17 producing cells were present in the CNS from DR3 KO mice compared to WT mice.", "In addition, DR3 KO mice have twice as many T cells in the CNS as WT mice.", "However, there was no difference in the spleen or in the lymph nodes.", "Example 2 ii.", "Results a. TL1A Costimulates Proliferation and Cytokine Production in CD4+ T Cells Through DR3 Exogenous TL1A can costimulate human and mouse T cells, but whether DR3 is the sole costimulatory receptor for TL1A and what role endogenously produced TL1A plays in mature T cell activation is not known.", "To investigate this, CD4+ T cells were purified from spleens and lymph nodes of wild-type (WT) or age- and sex-matched DR3 knockout (DR3 KO) mice (Wang et al., 2001) on a C57BL/6 background and activated through the TCR in the presence or absence of recombinant murine TL1A.", "Costimulation by other TNF family members has been shown to be maximal when CD28-mediated costimulation is blocked (Croft, 2003).", "TL1A also increased T cell proliferation most dramatically in the absence of CD28-mediated costimulation (FIG.", "8A).", "When CD28-mediated costimulation was present, TL1A only costimulated proliferation at lower doses of anti-CD3 (FIG.", "8A).", "The increased thymidine incorporation was due to increased cell division and not enhanced survival, as increased CFSE dilution and no significant changes in cellular viability induced by TL1A were observed.", "Importantly, DR3 KO cells were unresponsive to TL1A, indicating that DR3 is the major receptor that mediates costimulation by TL1A (FIG.", "8A).", "However, stimulation of DR3 through endogenous T cell-derived TL1A was apparently dispensable for T cell proliferation, since there were no deficits in proliferation in cultures of purified DR3 KO T cells (FIG.", "8A).", "TL1A costimulation was largely dependent on increased IL-2 production, as TL1A-induced proliferation was greatly reduced in IL-2-deficient T cells or after the addition of an antagonistic anti-IL-2Rα antibody (FIG.", "8B).", "To investigate the spectrum of cytokines that can be costimulated by TL1A and the dependence of cytokine production on DR3, IL-2, IFN-γ and IL-4 production were measured in WT or DR3 KO T cells activated in the presence or absence of recombinant TL1A.", "TL1A increased IL-2, IFN-γ, and IL-4 production by WT but not by DR3 KO T cells, with IL-4 being most prominently induced by TL1A in the presence of CD28 costimulation (FIG.", "8C).", "DR3-deficient T cells were unresponsive to TL1A, but had no defects in cytokine production compared to wild-type T cells.", "Thus, as with proliferative responses, DR3 is required for TL1A induced costimulation, but endogenously produced T cell-derived TL1A is not necessary for cytokine production by activated T cells under these conditions.", "Upregulation of the activation markers CD25 (IL-2Rα) and CD69 was enhanced by TL1A, especially at 24 hours after activation, but no defects in activation marker expression were observed in DR3-deficient T cells compared with wild-type controls (FIG.", "16).", "TL1A has been reported to costimulate memory, but not naïve T cells (Bamias et al., 2006).", "To address this issue, CD62Lhi/CD44lo naïve CD4+ T cells were purified from WT and DR3-deficient mice and activated with or without exogenous TL1A.", "TL1A mildly enhanced proliferation with or without CD28 costimulation, and also strongly increased IL-2 and IFN-γ production in a DR3-dependent manner (FIG.", "17A, 17B), showing that DR3 can function in naïve T cells.", "Percentages of memory phenotype CD44hi CD4+ T cells were also identical in age-matched DR3 KO and control mice (FIG.", "17C), indicating that TL1A costimulation of unseparated T cells is unlikely to be due to differences in the percentages of memory and naïve cells.", "b. Dendritic Cells Produce TL1A in Response to TLR and FcγR Stimuli and can Costimulate T Cells Through DR3 The lack of proliferative or cytokine production defects in purified DR3-deficient T cells suggested that other cell types may be the physiological source of TL1A.", "TL1A has been reported to be produced by human DC and monocytes after a variety of stimuli, and DCs would be a source of TL1A produced at the appropriate time and place for T cell costimulation.", "To test this, upregulation of TL1A gene expression was measured by Reverse Transcriptase Quantitative PCR (RT-qPCR) in purified splenic CD11c+ dendritic cells and bone marrow-derived DC stimulated with a variety of agents.", "LPS and Soluble Tachyzoite Antigen from Toxoplasma gondii (STAg), stimuli that act through Toll-Like receptors (TLR's) and that can induce expression of other TNF family members, induced rapid upregulatation of TL1A, with expression peaking at up to 100-fold above baseline at 3 hours, and rapidly declining after that (FIG.", "9A).", "Interestingly, Schistosoma Egg Antigen (SEA) from Schistosoma mansoni, which triggers alternative activation of DC to program T cells for Th2 differentiation, did not appreciably induce TL1A mRNA (FIG.", "9A, left panel).", "Stimulation of dendritic cells deficient in TLR signaling components showed that LPS induction of TL1A is mediated by TLR4 in a manner dependent on MyD88 and TIRAP (FIG.", "9B).", "Immune complexes acting through low-affinity Fc receptors have recently been shown to be a potent stimulus for TL1A production (Cassatella et al., 2007; Prehn et al., 2007).", "Stimulation of murine DC with plate-bound crosslinked mouse Ig (IC) also stimulated TL1A gene expression comparably to LPS (FIG.", "9C).", "Thus like other TNF family members, TL1A can be rapidly induced in DC through TLR and immune complexes.", "To test whether T cells could serve as an autocrine source of TL1A, purified T cells were stimulated through the TCR, and TL1A mRNA levels were measured by RT-qPCR.", "TL1A mRNA was upregulated after TCR stimulation, but with delayed kinetics compared with DC.", "Interestingly, TL1A upregulation was specifically dependent on DR3 expression, as DR3-deficient T cells showed dramatically reduced TL1A induction, but normal upregulation of IL-2 mRNA after activation (FIG.", "9D).", "Taken together, these data show that T cells can produce TL1A that acts in an autocrine manner to sustain its own expression, but T cell-derived TL1A is not necessary for proliferation or cytokine production by isolated T cells.", "To study the role of TL1A-DR3 interactions in a more physiological model of T cell activation, DR3-deficient mice were backcrossed to the Ovalbumin (Ova)-specific TCR transgenic line OT-II, and cultured naïve T cells from DR3 KO OT-II and OT-II control mice with Ova peptide and wild-type bone marrow-derived DC.", "Under these conditions, proliferation of DR3 KO OT-II cells was diminished especially at low concentrations of Ova (FIG.", "10A).", "The cytokine profile of T cells stimulated with Ova peptide and DC is characteristically dependent on the dose of antigen, with higher doses favoring IFN-γ production and lower doses favoring IL-4 production (Tao et al., 1997).", "DR3 KO OT-II cells produced less IL-2 at lower doses of Ova and lower amounts of IL-4 at all doses of Ova tested.", "By contrast, production of IFN-γ was higher than controls at all doses tested (FIG.", "10B).", "Analysis of T cell activation marker expression revealed that optimal upregulation of CD25 and CD71 was also DR3 dependent at low doses of Ova peptide (FIG.", "18).", "These data indicate that during interactions between T cells and dendritic cells presenting cognate antigen, TL1A-DR3 interactions function to costimulate T cell proliferation and production of IL-2, IL-4, but not IFN-γ.", "These alterations in cytokine production and proliferation in the absence of DR3 may influence T cell polarization.", "To test this, naïve CD4+ T cells from DR3 KO or control mice were activated in the presence of dendritic cells under conditions optimized for differentiation of Th1, Th2, or Th17 effector T cells or under neutral conditions, and was cytokine production measured after restimulation (FIG.", "11).", "In the absence of exogenous polarizing stimuli, DR3 KO T cells exhibited mild skewing towards a Th1-IFN-γ secreting profile expected on the C57BL/6 background.", "In addition, appropriate cytokines polarized DR3 KO cells normally towards IL-4, IFN-γ, or IL-17 producing cells, cultures of DR3 KO OT-II, and control OT-II T cells stimulated with DC and Ova were then set up and polarized with cytokines or Soluble Tachyzoite Antigen (STAg), which in addition to IL-12, induces TL1A production.", "These conditions also resulted in normal Th1 skewing by antigen-specific DR3 KO T cells (FIG.", "11B).", "Induction of the transcription factors T-bet, GATA-3, or RORγ by appropriate differentiation stimuli was also unaffected in DR3 KO purified T cells.", "Thus, DR3 appears to be dispensable for the differentiation of naïve T cells into Th1, Th2, or Th17 effector cell subtypes.", "c. DR3 is Dispensable for Primary Systemic T Cell Responses, but Essential for Immunopathology in Animal Models of T Cell-Mediated Disease To determine the role of DR3 in T cell differentiation and effector function in the intact immune system, disease models dependent on distinct T cell subsets were studied in DR3 KO mice.", "A Th2-dependent model of lung inflammation in which mice are primed systemically with Ova and Alum was first investigated and then locally challenged with Ova (Gavett et al., 1994).", "In three independent experiments, histological analysis showed that the airways in DR3 KO mice lung had less inflammation, including mucin production and peribronchial inflammation (FIG.", "12A).", "Standardized histopathology scores and cell counts in BAL were reduced in OVA-sensitized and challenged DR3 KO mice compared with DR3 WT mice sensitized and challenged in parallel with OVA (FIG.", "12B).", "Percentages of CD3+ and CD4+ T cells, invariant Vα14 positive T cells that recognize glycosphingolipid/CD1d tetramers, and eosinophils were all significantly reduced in lung cell preparations from Ova-sensitized and challenged DR3 KO mice compared with controls (FIG.", "12C).", "Localization of CD3+ cells in lung tissue from Ova-sensitized DR3-deficient mice by immunohistochemistry revealed fewer interstitial and peribronchial T cells compared with controls, and increased perivascular localization, suggesting a migration or survival defect of T cells in the lung.", "Similar increases in perivascular infiltrates were observed for macrophages (FIG.", "19).", "Levels of mRNA for IL-5 and IL-13, which are critical for Th2-mediated lung pathology, were markedly reduced in DR3 KO Ova-sensitized lungs, while IL-10 and IFN-γ were equally produced (FIG.", "12D).", "By contrast, when DR3 KO spleen cells from these mice were restimulated with Ova, there was normal production of IL-5 and IL-13, indicating that systemic priming of Ova-specific Th2 T cells was independent of DR3 (FIG.", "12E).", "In addition, DR3 KO splenocytes proliferated normally in response to Ova.", "Systemic Th2 function as assessed by the production of Ova-specific IgG1 and Ova-specific IgE after Ova priming was also normal in DR3 KO mice (FIG.", "12F).", "Thus, in this model of Th2-mediated lung inflammation, DR3 is required for Th2 effector cells to accumulate at the site of inflammation but not for systemic differentiation of Th2 T cells.", "Decreased T cells in the lung may result in defective recruitment of eosinophils and iNKT cells to the site of inflammation as was observed in the DR3 KO lung.", "To determine whether DR3 is required for diseases mediated by other T cell subsets, Experimental Autoimmune Encephalomyelitis (EAE), a Th17- and Th1-dependent autoimmune disease, was studied in DR3 KO mice.", "In four separate experiments, DR3 KO mice exhibited delayed and dramatically reduced paralysis as measured by clinical scores (FIG.", "13A).", "Despite resistance to EAE, T cells from draining lymph nodes of MOG-primed DR3 KO mice proliferated normally in response to MOG (FIG.", "13B).", "The percentage of CD4+ T cells in the spinal cord homogenates was markedly reduced in DR3 KO mice (FIG.", "13C).", "Within the T cell gate, the percentage of IFN-γ-producing cells was also reduced by two-fold in T cells from the spinal cords of DR3 KO mice (FIG.", "13C).", "The percentage of IL-17-producing cells was normal in DR3 KO mice within this gate, but overall was still reduced due to the decreased percentage of CD4+ T cells in the spinal cord.", "To examine the absolute levels of these cytokines in the inflamed spinal cord, mRNA for IL-17 and IFN-γ was measured by RT-qPCR in spinal cord homogenates.", "Both cytokines were reduced in spinal cord preparations from MOG-primed DR3 KO mice when normalized to the housekeeping gene β2-microglobulin, with IFN-γ being the most affected.", "However, when normalized to the expression of the T cell specific gene CD3-8, IL-17 and IFN-γ mRNA expression were not reduced in DR3 KO spinal cord.", "(FIG.", "13D).", "Thus, DR3 is also critical in this model of autoimmune demyelinating disease associated with a different set of cytokines than the Ova-induced lung inflammation model, and resistance to disease in DR3 KO mice correlated with decreased numbers of effector T cells in the target organ.", "In addition to their role in autoimmune diseases, effector T cells are important in controlling infections.", "It was decided to further investigate the role of DR3 signaling in toxoplasmosis, an infection in which IFN-γ-secreting Th1 cells are necessary for mice to survive acute infection.", "After infection with T. gondii, DR3 KO as well as control mice had 100% survival for seven weeks.", "Spleen cells isolated from DR3 KO infected mice at seven weeks post-infection and stimulated with STAg produced comparable amounts of TNF-α, IFN-γ, and IL-10 compared with controls (FIG.", "14).", "These data indicate that the priming and maintenance of effector Th1 cells in response to T. gondii is not dependent on DR3.iii.", "Experimental Procedures a. Reagents and Mice LPS from E. coli was obtained from Sigma.", "Soluble Tachyzoite Ag (STAg) was prepared from sonicated Toxoplasma gondii tachyzoites, and SEA was prepared from Schistosoma mansoni eggs as previously described (Grunvald et al., 1996).", "C57BL/6 mice were obtained from Jackson Laboratories.", "DR3 KO mice, generated as previously described (Wang et al., 2001), were backcrossed to the C57BL/6 background for at least eight generations.", "DR3 KO OT-II mice were generated by crossing DR3 KO mice to OT-II TCR transgenic mice (Taconic farms).", "IL-2−/− mice were a generous gift from Pushpa Pandiyan, NIAID.", "All antibodies were purchased from BD Pharmingen unless indicated otherwise.", "CD1d/PBS57 tetramers that recognize Vα14 iNKT T cells were prepared by the NIH tetramer core facility.", "b.", "Cell Preparation and Purification Splenic dendritic cells were sorted for high expression of CD11c+ on a MoFlo FACS sorter (Dako Carpenteria, Calif.) from liberase-digested spleens.", "The purity of CD11c+ DC was at least 97%.", "T cells were purified from spleen and lymph node cell suspensions by magnetic depletion of CD11b, PanNK, B220, NK1.1, CD24, CD16/32, GR-1, I-Ab using FITC-conjugated mAb to these antigens (BD Pharmigen), and anti-FITC microbeads (Miltenyi).", "To purify CD4+ T cells, anti-CD8-FITC was added to the above antibodies.", "For naïve T cells, the CD62L+ CD44− population of CD4+-purified cells was sorted after staining with PE-Cy5 anti-CD44 and PE anti-CD62L.", "Bone marrow dendritic cells were generated by culture with RPMI/10% FCS supplemented with 10 ng/ml of murine GM-CSF (PeproTech, Rocky Hill, N.J.).", "T-depleted APC were obtained by incubating spleen cell suspensions with anti-Thy1.1 for 10 min on ice followed by incubation with low-tox-M rabbit complement (Cedarlane Laboratories) for 30 min at 37° C. Cells were washed and incubated with 25 μg/ml of mitomycin C (Sigma) for 30 min at 37° C. c. T Cell Activation and Polarization For costimulation studies, CD4+ or naïve CD4+ cells were stimulated with platebound anti-CD3 mAb (5 μg/ml or at the indicated concentration, 145-2C11; BD Pharmingen) in the presence or absence of plate-bound anti-CD28 mAb (5 μg/ml) (37.51; BD Pharmingen).", "Recombinant mouse TL1A (R&D systems) was added at 10 ng/ml.", "For studies with IL2−/− mice, purified T cells were cultured as above, but in the absence or presence of 10 U/ml of IL-2.For DC-T cell co-culture studies, 104 bone marrow-derived DC were cultured with 105 OT-II or DR3 KO OT-II naïve CD4+ T cells per well and the indicated concentration of OVA323-339 peptide, with or without 10 μg/ml of mouse CTLA4/Fc (Chimerigen).", "On day 3, culture supernatants were collected for cytokine measurement, and cells were pulsed with 1 μCi of 3H-thymidine.", "After an additional 16-20 hours, 3H-thymidine incorporation was measured with a scintillation counter.", "For polarization studies, 8×105 T-depleted APC were cultured with 2×105 naïve CD4+ T cells from C57BL/6 or DR3 KO mice.", "Th1 polarization was driven with rIL-12 (20 ng/ml) (PeproTech, Rocky Hill, N.J.), and anti-IL-4 (10 μg/ml), Th2 polarization with rIL-4 (20 ng/ml) (PeproTech, Rocky Hill, N.J.), anti-IL-12 (10 μg/ml), and anti IFN-γ (10 μg/ml), Th17 polarization with rhTGFα (5 ng/ml) (eBioscience), IL-6 (20 ng/ml) (eBioscience), anti-IL-12 (10 μg/ml), anti IFN-γ (10 μg/ml) and anti-IL-4 (10 μg/ml), Th0 polarization with anti-IL-12 (10 μg/ml), anti IFN-γ (10 μg/ml) and anti-IL-4 (10 μg/ml).", "After 4 days of culture, intracellular cytokine staining was performed as described below.", "For polarization studies with STAg, 5×104 splenic DC were cultured with 105 OT-II or DR3 KO OT-II naïve CD4+ T cells per well with 1 μM OVA323-339 peptide.", "Th1 polarization was driven with rIL-12 (10 ng/ml), Th2 polarization with rIL-4 (10 ng/ml), and STAg polarization with 5 μg/ml STAg.", "After 72-h culture, supernatants were replaced with fresh medium containing 10 U/ml rIL-2 and, after an additional 2-3 days, intracellular cytokine staining was performed as described below.", "d. Induction of Experimental Allergic Encephalomyelitis Mice were immunized subcutaneously with myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide in CFA with pertussis toxin administrated IP on days 0 and 2 to induce EAE.", "Five to eight mice were included per group and were scored.", "Clinical assessment of EAE was performed daily according to the following criteria: (0), no disease; (1), tail paralysis; (2), hind leg weakness; (3), full hind leg paralysis; (4), complete hind limb paralysis plus front limb paraparesis; (5), death.", "Cells from the CNS were isolated using the Neural Tissue Dissociation Kit from Miltenyi Biotec according to the manufacturer's recommended protocol.", "Spleen cells from MOG-sensitized animals were isolated using CD4 beads.", "The cells were restimulated in the presence of irradiated T-depleted splenocytes as APC and the indicated concentrations of MOG peptide in 96-well plates.", "On day 3, the cells were pulsed with 3H-thymidine for 6 h and then harvested and counted on a scintillation counter.", "e. Ova-Induced Lung Inflammation On days 0 and 7, mice were sensitized systemically via a 200-μl intraperitoneal (i.p.)", "injection containing either 100 μg Chicken Ova (Sigma) or PBS emulsified in an equal volume mixture with alum (Pierce Laboratories, Rockford, Ill.).", "For assessment of pulmonary inflammation, mice were challenged with 100 μg Ova or PBS/30 μl inoculum intratracheally (i.t.)", "on day 14 and intranasally (i.n.)", "on day 15.Mice were euthanized 48-72 h after the final challenge to evaluate cell infiltration, cellular inflammation in the lung, and cytokine levels in the sera and bronchoalveolar lavage fluid (BALF).", "BAL fluid was obtained by direct cannulation of the lungs with a 20-gauge intravenous catheter and lavage with 500 μl 1% fetal bovine serum (FBS) in PBS (for cytokine analysis) and with 750 μl 1% FBS in PBS (for analysis of cellular infiltration).", "Samples for cytokine analysis were stored at −80° C. Samples for cellular analysis were prepared as a cytospin (Thermo-Shandon, Pittsburgh, Pa.) for differential cellular analysis after staining with Kwik-diff (Thermo-Shandon), and a portion was used to determine total cell counts.", "Lung histology was scored by a reader with experimental conditions masked as described previously (McConchie et al., 2006) f. Toxoplasma Infection T. gondii cysts from the ME-49 strain were prepared from the brains of infected C57BL/6 mice.", "For experimental infections, mice were inoculated i.p.", "with an average of 20 cysts/animal.", "At 7 weeks post-infection, the number of cysts in the brain of individual infected animals was determined.", "Spleen cells were harvested, cultured, and stimulated with either anti-CD3 and anti-CD28 or 5 μg/ml STAg.", "Supernatants were harvested after 72 h and analyzed for cytokine production.", "g. Cytokine and Immunoglobulin Measurement Detection of IFN-γ-, IL-4-, and IL-17-producing cells was determined by intracellular cytokine staining using anti IFN-γ-APC, anti IL-4-PE, anti-IL-17-PE (BD Biosciences).", "Briefly, cells were stimulated for five hours with anti-CD3 and anti-CD28 or phorbol myristate acetate and ionomycin, with monensin added after two hours.", "Cells were fixed in 3% paraformaldehyde, permeabilized in 0.1% saponin, and analyzed on a FACS Calibur flow cytometer (Becton Dickinson).", "Cytokine production in cell culture supernatants was analyzed by Cytometric Bead Array (BD Biosciences).", "Serum immunoglobulins were measured by ELISA following the manufacturer's instructions (Bethyl Labs), and OVA-specific IgG1 and IgE were measured by IgG1- or IgE-specific ELISA using plates coated with 50 μl d OVA (100 μg/ml).", "h. TL1A Induction in Dendritic Cells and T Cells Bone marrow-derived DC, or splenic CD11c+ DC from C57BL/6 mice and the indicated knock-out mice were cultured and stimulated for the indicated time with or without 100 ng/ml LPS, 20 μg/ml SEA or 10 μg/ml STAg.", "Stimulation with Ig cross-linking was performed by coating plates with 0.5 mg/ml mouse IgG (Jackson Immunoresearch) for 1 h at 37° C., followed by 50 μg/ml sheep anti-mouse IgG (Jackson Immunoresearch) for 1 h at 37° C. Purified T cells were stimulated with 5 μg/ml anti-CD3 and anti-CD28 for the indicated time.", "i.", "Measurement of RNA by Quantitative RT-PCR Total RNA was isolated from cells using TriZOL and the Pure Link™ Micro- to midi kit (Invitrogen).", "Quantitative RT-PCR was performed using an ABI PRISM 7700 sequence detection system using SuperScript One-Step RT-PCR System (Invitrogen).", "Pre-designed Primer/probe sets were from Applied Biosystems with the exception of TL1A, which was detected with primers designed to recognize full-length TL1A (forward: CCCCGGAAAAGACTGTATGC; reverse: GGTGAGTAAACTTGCTGTGGTGAA; probe: TCGGGCCATAACAGAAGAGAGATCTGAGC).", "Probes specific for β2-microglobulin or CD3-8 were used as internal controls.", "Example 3: TL1A-Induced Inflammatory Bowel Disease To evaluate the function of TL1A, transgenic mice were generated in which TL1A is constitutively expressed on dendritic cells and T cells.", "For T cells, an improved version of the human CD2 enhancer construct (Zhumabekov, T., et al.", "1995) was used, and for dendritic cell-specific expression, a CD11c promoter construct was used (Brocker, T., et al.", "1997).", "An Influenza Hemagglutinin (HA) epitope tag was added to the N-terminus of the TL1A cDNA for identification of transgene-derived TL1A mRNA and protein.", "Transgene expression was assessed in each founder line of transgenic mice.", "For the CD2-TL1A construct, four lines (R1, R6, U8, and Z9) had similar detectable levels of TL1A expression in the spleen and lymph node T cells assayed by intracellular flow cytometry for the HA tag in T cells gated on CD3, with no HA staining detected in other immune cell subsets, and were used in subsequent analysis.", "For the CD11c-TL1A transgenic mice there was a wider range of expression.", "Transgene expression relative to endogenous TL1A ranged from 2 to over 500-fold, and founders were divided into high and low expressers based on a cutoff of 8-fold overexpression.", "Increased numbers of CD69+ T cells were present in spleen and lymph nodes from both CD2 and CD11c TL1A transgenic lines.", "Spontaneous T cell activation was more prominent in CD4 than CD8 T cell subsets.", "These results indicate that deregulation of TL1A in either T cells or DC results in spontaneous T cell activation and disruption of T cell homeostasis.", "On further inspection of transgenic mice from both CD11c-TL1A and CD2-TL1A lines, frequent bowel edema and evidence of bowel wall thickening throughout the small bowel were observed.", "Incidence of these features was virtually 100% in the four lines of CD2-TL1A transgenic mice under study and correlated with the level of transgene expression in the CD11c-TL1A lines.", "Bowel wall thickening, inflammatory infiltrates, goblet cell hyperplasia, enlargement of villi, and distortion of normal architecture can be seen (FIG.", "21).", "These changes were quantitated by an experienced observer blinded to the status of the mice according to a scoring scheme developed for TNBS colitis that encompasses inflammatory cell infiltrates, elongation and destruction of villi, crypt abscesses, and thickening of the muscularis layers (Neurath, M., et al.", "2000)(FIG.", "21).", "The terminal ileum was most prominently involved on both gross inspection and histopathology in both CD11c and CD2-TL1A transgenic mice, with the colon relatively spared (FIG.", "21B, C).", "Intestinal inflammation was associated with weight loss in these mice, again dependent on the level of transgene expression (FIG.", "21C).", "These observations establish TL1A transgenic mice as a new animal model of inflammatory bowel disease, with some features strikingly similar to human Crohn's disease, including transmural inflammation and a predilection for the terminal ileum.", "Interestingly, a number of recent reports describe increased expression of TL1A and DR3 in the lamina propria of biopsy specimens of patients with ulcerative colitis or Crohn's disease.", "Increased TL1A and DR3 expression was also noted in two other animal models of IBD, the SAMP1/YitFc and TNPΔARE strains (Bamias, G., et al.", "2003; Bamias, G., et al.", "2006).", "Taken together with the discovery that deregulated TL1A expression provokes spontaneous IBD in transgenic mice, TL1A-DR3 interactions can be important in the pathogenesis of IBD and constitute a promising therapeutic target in IBD and related inflammatory diseases with a T cell component, including Rheumatoid Arthritis.", "iv.", "Characterization of the Pathogenic Cell Types and Role of Gut Flora in TL1A-Driven IBD.", "Immunohistochemical and immunofluorescence studies are carried out on tissue sections from selected CD2-TL1A and CD11c-TL1A transgenic mice.", "Initial studies localize T cells with anti-CD3 and macrophages with F4-80 by immunostaining frozen sections of intestine from TL1A transgenic mice.", "FACS analysis is performed on intraepithelial and lamina propria lymphocyte preparations from involved areas of bowel from TL1A transgenic mice.", "αβ, γδ□ and NKT cells are enumerated along with NK cells and B cells, and activation status is examined with CD25, CD69, and CD71 surface markers.", "FoxP3+CD25+ Tregs are also enumerated in these samples to determine whether there is an attempt at immune counter-regulation through Treg, as has been seen in other models of T cell-driven immunopathology (Tang, Q., et al.", "2006).", "Although T cells are the main cell type expressing the TL1A receptor DR3, TL1A expression has been found in NKT cells, NK cells, and B cells.", "Thus, enforced TL1A can expand other immune cell subsets that could mediate IBD in these mice.", "To determine which lymphocyte subsets are required for TL1A-driven colitis, TL1A transgenic mice are crossed to various lines of knockout mice which lack different lymphocyte subpopulations.", "TL1A transgenic mice are first crossed to RAG-deficient mice to determine dependency on T, B, and NKT cells.", "If these mice lack inflammatory bowel disease, then the dependence of TL1A-driven IBD has been shown on the adaptive immune system.", "Other crosses are then performed to determine the requirement for αβ T cells (TCR alpha knockout), NKT cells (CD1d knockout), NK cells (IL-15 knockout), and B cells (IgH knockout) mice.", "If αβ□T cells are found to be required for IBD in TL1A transgenic mice, then the contribution of different T cell subsets can be examined through crossing CD2-TL1A transgenic mice to Class I or Class II MHC-deficient mice, which lack CD8 and CD4 T cells, respectively.", "If T cells are implicated, IBD could result from non-antigen-specific costimulation by TL1A or, alternatively, specific T cell reactivates (i.e.", "to gut-derived antigens) could be required for disease induction.", "To test this, TL1A mice are crossed with TCR transgenic mice bearing irrelevant specificities such as OT-II ovalbumin-specific TCR transgenic mice.", "If autoreactive or gut flora-reactive T cells are necessary for TL1A-driven IBD, then these TCR transgenes can ameliorate disease.", "v. Characterization of the Pathogenic Cytokines in TL1A-Driven IBD.", "Inflammatory bowel disease models have been found to depend on a wide variety of different cytokines (Strober, W., et al.", "2007).", "Initially, interest focused on interferon-□□ and IL-12 and, indeed, antibodies against the p40 subunit of IL-12 are effective in human inflammatory bowel disease and mouse IBD models.", "More recently, it has been discovered that p40 is a component of IL-23, an IL-12 family cytokine that has been shown to be critical in inflammatory bowel disease.", "IL-23 acts at least in part through enhancing the differentiation and/or survival of T cells producing IL-17, a cytokine that potently attracts and activates neutrophils and monocytes (Fuss, I. J., et al.", "2006; Hue, S., et al.", "2006; McKenzie, B. S., et al.", "2006).", "Experiments have been conducted to determine the predominant cytokines expressed in TL1A-induced IBD to determine which effector cell populations are critical in this disease and to better understand the effects of chronic TL1A stimulation.", "Quantitation of cytokines from RNA extracted from ileum and other regions of the intestines in TL1A transgenic mice revealed consistent elevation of IL-17 and IL-13 (FIG.", "21E).", "Interestingly, IL-22, another cytokine produced by the Th17 subset of T cells, was not detectable, and IFN-□□□□ the characteristic product of Th1 cells, was also not elevated over controls.", "Examination of T cells in the mesenteric lymph nodes revealed that IL-17-producing T cells were the most elevated over controls compared with IFN-□ and IL-4.Blocking anti-cytokine antibodies or knockout mice in genes known to be critical for development of particular T cell subset (e.g.", "IL-17, STAT4, STATE, ROR-□) can then be used to determine which of the cytokines and Th cell subsets are required for the development of TL1A-driven IBD.", "vi.", "Determination of Whether TL1A Blocks Regulatory T Cell Function or Renders T Cells Resistant to Treg.", "Whether TL1A affects the generation or function of natural Tregs is not known.", "In rheumatoid arthritis, the related cytokine TNF was shown to impair the function of FOXP3+ regulatory T cells independent of their numbers (Nadkarni, S., et al.", "2007; Valencia, X., et al.", "2006).", "FOXP3-positive Tregs are present in normal numbers in DR3 knockout mice and, interestingly, are present in increased numbers in the mesenteric lymph nodes of TL1A transgenic mice.", "To aid in the isolation of Tregs from TL1A transgenic mice, which have increased numbers of activated CD25+ T cells, selected lines of TL1A transgenic mice are crossed with FOXP3-GFP reporter mice to make sure that only FOXP3-positive Tregs are studied in these experiments.", "Tregs isolated from TL1A transgenic mice are assayed for their function, and it also is tested whether TL1A can block the suppressive function of normal Tregs through the use of CD2-TL1A transgenic responder cells (Tresp) and the addition of TL1A to Treg/Tresp cultures.", "In vivo assays of Treg function are also performed, in which Tregs are transferred with naïve CD45RB-hi cells into immunodeficient hosts (Powrie, F., et al.", "1993).", "Reciprocal experiments are carried out with either Treg or naïve T cells derived from CD2-TL1A transgenic mice to determine whether Treg function or the ability of naïve T cells to cause IBD is influenced by TL1A.", "vii.", "Requirement for TL1A-DR3 Interactions in the Development of IBD.", "It is also determined whether DR3 is required for the development of colitis in the absence of transgene-derived TL1A.", "The colitis induced by intrarectal administration of the hapten TNBS has been extensively characterized.", "It is known that colitis requires T cells, and is also dependent on TNF and IL-12p40 (Neurath, M., et al.", "2000; Neurath, M. F., et al.", "1997).", "Recent evidence has also implicated the IL-23 target cytokine IL-17 in pathogenesis of this experimental disease (Zhang, Z., et al.", "2006).", "Resistance to EAE and Ova-induced asthma indicates that DR3-deficient mice can be resistant to TNBS colitis compared with littermate controls.", "To do these experiments, DR3 KO mice are backcrossed onto the susceptible C57Bl/10 strain.", "Alternatively, while backcrossing is in progress, susceptible mice are treated with TL1A blocking antibodies prior to or after induction of TNBS colitis.", "DR3-deficient T cells are also transferred into immunodeficient hosts in the transfer model of colitis to determine if DR3 on T cells is necessary in this model of colitis.", "Example 4: Elevated TL1A in Rheumatoid Arthritis TL1A has been detected in rheumatoid synovium.", "We used novel monoclonal antibodies against human TL1A to determine the factors that induce TL1A and the specificity of elevated TL1A levels in the synovial fluid (SF) or blood for RA versus other rheumatic diseases.", "In the mouse collagen-induced arthritis (CIA) model, we blocked TL1A-DR3 interactions with neutralizing antibodies against TL1A and measured the effects of TL1A blockade on anti-collagen antibodies, clinical joint inflammation, and erosions by micro CT. TL1A was induced by Fc receptor crosslinking and, to a lesser extent, by plasma membrane TLR in human monocytes.", "Significantly higher blood and SF levels of TL1A were seen in patients with RA compared to other rheumatic diseases.", "Plasma TL1A was predictive of SF TL1A levels.", "However, SF TL1A was elevated independently of TNF and disease activity in RA patients.", "TL1A blockade was efficacious in reducing clinical joint scores in CIA and dramatically reduced bone erosions independently of effects on paw swelling.", "TL1A is important in both human and mouse autoimmune arthritis, especially in the pathogenesis of erosions.", "We disclose TL1A blockade as a potent disease-modifying treatment for RA that acts independently of TNF.", "Monocyte Cell Culture and Stimulation Elutriated monocytes from normal donors were obtained from the NIH transfusion medicine department under NIH IRB-approved clinical protocols.", "Monocytes were cultured at 1×106 cells/ml in RPMI medium with 10% FCS in a 37° C., 5% CO2 incubator.", "At specified time points, culture supernatant was collected for measurement of TL1A, and cells were harvested for qRT-PCR for measurement of TL1A mRNA.", "LPS (Ultrapure Salmonella Minnesota R595, List Biological Laboratories inc., Campbell, Calif.) was added at the indicated concentrations.", "Stimulation with immune complexes was performed as previously described.", "Quantitative RT-PCR was performed with the use of an ABI PRISM 7700 sequence detection system with qScript One-Step qRT-PCR Kit, Low ROX (Quanta BioSciences, Inc.).", "Predesigned primer/probe sets were from Applied Biosystems, and the sequences designed to detect full-length TL1A are forward: 5′-CCCCGGAAAAGACTGTATGC-3; reverse: 5′GGTGAGTAAACTTGCTGTGGTGAA 3′; probe: 5′-TCGGGCCATAACAGAAGAGAGATCTGAGC-3′).", "Each measurement was normalized to expression of β2 microglobulin (delta Ct).", "2-ΔΔCT was then used as the level of gene expression.", "Gene expression levels were normalized to the level present in un-stimulated cells.", "Human Samples Simultaneous synovial fluid and plasma samples were obtained at the Los Angeles County+University of Southern California Medical Center (IRB protocol HS-05-00270).", "Underlying causes of joint effusions were determined by the medical history, physical examination, and synovial fluid analyses.", "Treatment data was not available.", "Synovial fluids from patients with osteoarthritis, rheumatoid arthritis (RA), psoriatic arthritis, gout, and pseudogout were obtained from discarded de-identified, anonymized clinical samples obtained at the Brigham and Women's Hospital Rheumatology clinic.", "Treatment data was not available.", "Sera from systemic lupus erythematosus (SLE) patients at HSS had been previously collected for another study.", "Demographic data and SLE disease activity data (SELENA-SLEDAI) were recorded at the time of their clinical visit.", "All data were de-identified, and all patients signed an IRB-approved informed consent prior to blood drawing.", "Sjogren's disease patient serum samples were obtained from Dr. Gabor Illei at National Institute of Health (NIH) under IRB-approved protocol numbers 99-D-0070 and 84-D-0056.Serum samples from RA patients were provided by Dr. Raphaela Goldbach-Mansky at NIH under IRB-approved protocol number 00-AR-0222.Ankylosing spondylitis (AS) patient serum samples were provided by Dr. Michael Ward at NIH under IRB-approved protocol number 03-AR-0131.Measurement of TL1A by ELISA A commercially available human TL1A ELISA kit (PeproTech, cat no.", "900-K290) was used to measure TL1A in cell culture supernatants.", "For measuring human TL1A in matching plasma and synovial fluid samples, ELISA was performed as follows: 96-well, flat-bottom plates were coated with 1 μg/mL-mouse anti-human TL1A (clone 1A9) in PBS overnight at 4° C. Plates were blocked with blocking buffer (5% BSA, 0.1% Tween 20 in PBS) for 1 hour.", "25 μL of sample diluted 10-fold with 225 μL sample diluent (1% BSA, 0.1% Tween 20 in PBS) were loaded into each well, and the plates were incubated for two hours at 37° C. TL1A was detected by polyclonal biotinylated rabbit anti-human TL1A Ab followed by Steptavidin-Horseradish peroxidase (SA-HRP) 0.5 μg/mL for one hour at 37° C. TMB (3,3′,5,5′-tetramethylbenzidine) was used as the substrate.", "Reactions were stopped with 100 μL 1N sulfuric acid, and OD 450 nm was measured.", "The Standard curve was generated using recombinant human TL1A (PeproTech) diluted in standard diluent (sample diluent with added 10% pooled normal human sera).", "An independent bead-based assay system was developed using anti-human TL1A antibody (clone 1A9) conjugated onto Bio-Plex COOH beads (Bio-Rad).", "3000 anti-TL1A conjugated beads were added into each well of a 96-well filter plate (MultiScreen HTS™ by Millipore, Cat No.", "MSBVN1250), followed by 50 μL serum or synovial fluid.", "Synovial fluid was diluted two-fold using Bio-Plex Human Serum Diluent (Bio-Rad, Cat no.", "171-305000).", "Samples and standards were incubated for 30 minutes, followed by 30 minutes incubation with 25 μL 1 μg/mL biotinylated polyclonal anti-human TL1A (PeproTech, Cat no.", "500-P240Bt), and 50 μL of 1:100 diluted SA-PE (Bio-Plex Cytokine Reagent Kit, Bio-Rad, 171-304001).", "Each well was re-suspended with 125 μL of assay buffer, and cytokine levels were measured with the Bio-Plex 200 System (Bio-Rad).", "Data was analyzed using Prism (GraphPad Software, Inc.) software.", "For TNF assay, the Bio-Plex Pro Human Cytokine TNF-α set was used according to the manufacturer's instructions (Bio-Rad, Cat no.", "171-B5026M).", "Induction of Collagen-Induced Arthritis (CIA) and Administration of Blocking Reagents Male DBA/1J mice (8-10 weeks old) obtained from the Jackson Laboratory (Bar Harbor, Me.)", "were injected intradermally with 100 μg chicken collagen type II (CII) in complete Freund's adjuvant (1:1, w/v) to the tail base at day 0 and boosted with an intradermal injection of 100 μg CII in incomplete Freund's adjuvant (1:1, w/v) on day 21.The mice were then randomized at day 21 to receive either control or treatment.", "Mice in the treatment group were injected i.p.", "with 20 mg/kg hamster anti-mouse TL1A antibody (clone 5G4.6) every seven days starting on day 21.Control group mice received 20 mg/kg hamster immunoglobulin.", "Mice were euthanized at day 49.Hind legs were cut above the knees and were fixed in 10% formaldehyde.", "Animals were used under protocols approved by the NIAMS ACUC.", "Assessment of Clinical Severity of Arthritis in CIA The development of arthritis was evaluated by macroscopic scoring of each paw on a 0-4 scale previously described.", "Scoring was done by two separate investigators blinded to the randomization, and the average score of each mouse was used.", "ELISA for Measuring Anti-Chicken Collagen IgG 96-well, flat-bottom plates were coated with 100 μL, 50 μg/mL chicken collagen dissolved in 0.05M TRIS-0.2M NaCl overnight at 4° C. Plates were blocked with 200 μL blocking buffer (1% BSA in PBS) for 30 minutes at room temperature.", "50 μL of samples of 5-fold serially diluted serum from 1:100 to 1:12500 with sample diluent (1% BSA, 0.05% Tween 20 in PBS) were loaded in duplicate wells, and the plates were incubated for two hours at room temperature.", "Antibodies were detected with 5 ng/mL goat anti-mouse HRP (Pierce, cat.", "no.", "1858413) for one hour at room temperature and detected with substrate detection kit (R&D, cat.", "no.", "DY999), stopped by 50 μL 2M H2SO4, OD 450 measured.", "Micro-Computed Tomography (Micro-CT) and Assessment of Erosions Legs from CIA experiments were stored in 10% formaldehyde until they were scanned.", "Micro-CT of mouse anatomy was performed with a SkyScan 1172 Micro Xray CT scanner (MicroPhotonics, Inc. Allentown Pa., USA, SkyScan, Kontich, Belgium) with the x-ray source (focal spot size 4 micrometers, energy range 20-100 kV) biased at 44 kV/22 microamps and with a 0.5 mm aluminum filter to reduce beam hardening The images were acquired with a voxel size of 12.17 micrometers, with the camera to source distance of 220 mm and an object to source distance of 116 mm.", "450 projections were acquired with an angular resolution of 0.4 degrees through 180 degrees rotation.", "8 frames were averaged for each projection radiograph with an exposure time of 295 ms per frame.", "The scan duration was approximately 40 minutes.", "Tomographic images were reconstructed using vendor-supplied software based on the Feldkamp cone beam algorithm.", "Reconstructed images were then made into three-dimensional image using CTAn (v.1.10), then visualized using CTVol (v.2.1) (SkyScan).", "Three-dimensional images were scored on de-identified 3-D reconstructions by two separate investigators based on the scoring system described.", "Fc receptor (FcR) cross-linking and TLR ligands induce TL1A expression in human monocytes.", "In RA, FcR cross-linking by immune complexes and stimulation of TLRs by endogenous ligands may sustain inflammation by stimulating monocytes and other innate immune cells in the joint.", "Accordingly, we tested the ability of immune complexes and TLR ligands to induce expression of TL1A by human monocytes.", "Both FcR cross-linking and LPS induced TL1A at the mRNA level, with levels peaking at 18 hours and then rapidly declining, consistent with degradation of TL1A RNA governed by AU-rich elements present in the 3′ untranslated region of the TL1A mRNA.", "The peak of TL1A induction was ˜6-fold higher following FcR cross-linking than following optimal concentrations of LPS.", "At the protein level, FcR cross-linking induced higher levels of TL1A that were detectable at 18 hours, whereas LPS-induced TL1A was only detectable at 48 hours, with TL1A production approximately 10-fold lower with optimal doses of LPS than with FcR cross-linking.", "TLRs can be divided into subclasses depending on whether they activate signaling pathways linked to the adaptor protein MyD88, TRIF, or both.", "To determine which of these signaling pathways are important in induction of TL1A expression, we stimulated human monocytes with a panel of TLR ligands specific for each receptor.", "Stimulation through TLR1, 2, 4, and 6 was the most efficient at inducing TL1A; TLR 5 and 9 were intermediate; and stimulation through TLR 3, 7, and 8 had no effect on TL1A production.", "These results are consistent with MyD88-dependent rapid NF-kB upregulation being important in TL1A induction, since TLR 3, 7, and 8 poorly activate MyD88.These results are also consistent with those obtained with murine DC, in which TL1A production in response to LPS is primarily dependent on MyD88.TL1A is a Biomarker for Rheumatoid Arthritis in Synovial Fluid and Blood Given the potent ability of immune complexes to promote TL1A production in vitro, we reasoned that this cytokine may be preferentially elevated in RA, in which rheumatoid factor (RF) and other immune complexes stimulate innate immune cells.", "To that end, we measured TL1A levels in matched samples of plasma and SF from a cohort of patients with RA (39 samples from 31 patients) or other types of arthritis (37 samples from 31 patients), including psoriatic arthritis, crystal-induced arthritis, reactive arthritis, osteoarthritis, non-specific inflammatory arthritis, juvenile inflammatory arthritis, or infectious arthritis.", "The majority (27 of 39) of SF samples from RA patients had TL1A levels above 0.1 ng/mL, with a mean of 0.59 ng/mL and up to 3.25 ng/mL detected.", "By contrast, only 2 of 37 non-RA samples (one each from a patient with reactive arthritis and a patient with psoriatic arthritis) contained more than 0.1 ng/mL TL1A.", "In plasma, a smaller but still significant percentage of RA patients had elevated TL1A levels, while no samples from patients with other arthritides had detectable TL1A levels.", "Five RA and five non-RA patients contributed more than one sample to this cohort.", "In SF, TL1A levels fluctuated depending on the day of SF collection.", "In plasma, however, TL1A levels of patients with repeated measurements remained fairly constant, either highly elevated (>2 ng/mL) or below 0.1 ng/ml.", "This likely reflects the variability in inflammation between involved joints among patients subjected to repeated synovial aspirations.", "Elevated TL1A correlated more with markers such as anti-CCP that predict more severe disease and erosions than with disease activity at the time of sample collection.", "Among RA patients tested for anti-CCP antibodies, those with a positive anti-CCP (n=15) had significantly higher level of TL1A in SF (p=0.039) and a trend toward higher TL1A in plasma (p=0.129) than in those without (n=4).", "Comparing TL1A level in SF and plasma between RA patients with or without RF was not feasible because most of the patients in this cohort were sero-positive.", "Still, sero-negative patients (n=2) had mostly undetectable TL1A in both SF and plasma, suggesting that TL1A may be preferentially elevated in patients with RF.", "However, the quantitative level of RF or anti-CCP did not correlate with TL1A levels in plasma or SF.", "In addition, TL1A levels in SF or plasma did not correlate with measures of clinical severity including DAS-28 score, ESR, CRP, or tender/swollen joint counts, nor did SF TL1A levels correlate with SF WBC counts.", "There was a trend toward higher TL1A (n=9) in both SF (mean 0.68 ng/mL in erosive vs 0.55 ng/mL in non-erosive) and in plasma (mean 1.09 ng/mL in erosive vs 0.25 ng/mL in non-erosive).", "Of note, there was a linear correlation between plasma and SF TL1A levels in 39 matched RA plasma and SF samples (R2=0.52, p<0.0001), indicating that serum TL1A may be a surrogate for TL1A in the joint.", "To determine the generalizability of these findings, we measured TL1A with a bead-based fluorescent TL1A assay in SF samples from an independent cohort of patients with RA or other arthritides.", "Inter-assay variability between this assay and the one used was less than 10% for samples with values above 100 pg/ml, and this bead-based assay had the additional capability of detecting TL1A levels as low as 10 pg/ml.", "In this second cohort, SF TL1A levels were significantly higher in RA than in patients with osteoarthritis (OA), gout or pseudogout, or psoriatic arthritis (PsA), although SF TL1A levels in the other inflammatory arthritides were also significantly higher than in OA.", "Although TNF, a key pathogenic cytokine in RA, can induce TL1A expression in endothelial cells, chondrocytes, and synovial fibroblasts, SF levels of TNF and TL1A did not correlate in 17 RA samples tested.", "Thus, there appears to be a TNF-independent component to TL1A expression in SF.", "RA is not the only rheumatic disorder associated with circulating immune complexes.", "Anti-nuclear antibodies (ANA) complexed with components of chromatin are associated with SLE and Sjogren's syndrome.", "To determine whether serum TL1A levels are also elevated in these disorders, we tested sera from patients with Sjogren's syndrome and SLE over a wide range of disease activity and compared these to sera from an independent cohort of RA patients to sera from healthy volunteers.", "Serum TL1A levels were significantly elevated in patients with RA compared to normal controls, none of whom had detectable serum TL1A.", "In this cohort of RA patients, anti-TNF treatment status did not correlate with TL1A values.", "Serum TL1A levels were elevated in Sjogren's syndrome, but not to the extent seen in RA (RA versus Sjogren's, p=0.0006).", "Moreover, TL1A was undetectable in the serum of all but three SLE patients.", "Each of these 3 SLE patients had high SLEDAI levels (8-12), and two of them had arthritic flares at the time of sample collection.", "As an additional control, we measured the level of TL1A in the serum of patients with ankylosing spondylitis (AS), which is not associated with circulating immune complexes.", "Only a minority of AS serum contained TL1A at levels higher than 100 pg/ml.", "TL1A was significantly less elevated than in RA (t test of RA versus AS, p=0.0003).", "However, as in Sjogren's syndrome, TL1A was still significantly elevated in the serum of AS patients compared to healthy controls.", "There was no correlation of TL1A levels with number of affected peripheral joints, degree of spine ankylosis, anti-TNF treatment, or overall disease activity in AS.", "Taken together, these results indicate that RA is more strongly associated with increased TL1A levels than are other rheumatic diseases, and elevated serum TL1A can be considered a biomarker for seropositive RA in the setting of inflammatory arthritis.", "Blocking TL1A-DR3 interactions improves clinical outcome and bony erosions in CIA.", "Previous studies have found a beneficial effect of TL1A in murine CIA, but the effects of TL1A blockade on bony erosions have not been quantitated.", "To these ends, we administered an antagonistic anti-TL1A monoclonal antibody to DBA/1 mice at the time of boosting with antigen in CIA.", "Significant reductions in total joint scores were observed for the ensuing 28 days, particularly at earlier time-points.", "The onset of measurable clinical signs of arthritis was significantly delayed by anti-TL1A mAb.", "Interestingly, the decrease in the clinical severity in mice treated with anti-TL1A was not associated with decreases in titers of anti-collagen antibodies.", "Taken together, these data show that blocking TL1A-DR3 interactions potently reduces the clinical inflammatory signs of CIA without affecting systemic immune responses against the collagen immunogen.", "Since blocking TL1A-DR3 interactions clearly improved the clinical severity of CIA, we assessed whether these treatments also prevented bone erosions.", "We used micro-computed tomography (micro-CT) to provide a quantitative and global assessment of erosions.", "Anti-TL1A treatment dramatically reduced erosions in the hind-paws of mice induced to develop CIA.", "Quantitation of erosions in hind-paws according to a scoring system that takes account of peri-articular erosions and deformities in each joint in the hind-paws showed a significant reduction in average and maximum erosion scores in TL1A-treated mice.", "The reduction was especially pronounced in the MTP joints (*p=0.042) and in toes (*p=0.015).", "Also, generalized deformity occurred in only the control group (20%, versus 0% in the treatment group).", "Strikingly, erosions in anti-TL1A-treated mice were significantly reduced in paws with similar maximum clinical scores (2-way ANOVA p<0.0001 for treatment effect independent of maximum clinical score, p<0.0001 for treatment and p<0.0001 for maximum clinical score).", "This indicates that anti-TL1A antibody treatment not only diminished the erosions by inhibiting clinical arthritis, but also provided protection against erosions independent of inflammation as measured by the clinical joint score.", "Example 5: Sequencing of the Hybridoma Anti-Human TL1A Clone 1A9 Total RNA was extracted from frozen anti-human TL1A clone 1A9 hybridoma cells and cDNA was synthesized from the RNA.", "PCR was then performed to amplify the variable regions (heavy and light chains) of the antibody, which were then cloned into a standard cloning vector separately and sequenced.", "Total RNA was isolated from the hybridoma cells following the technical manual of TRIzol® Reagent.", "The total RNA was analyzed by agarose gel electrophoresis.", "Total RNA was reverse transcribed into cDNA using isotype-specific anti-sense primers or universal primers following the technical manual of PrimeScript™ 1st Strand cDNA Synthesis Kit.", "The antibody fragments of VH and VL were amplified according to the standard operating procedure of RACE of GenScript.", "Amplified antibody fragments were separately cloned into a standard cloning vector using standard molecular cloning procedures.", "Colony PCR screening was performed to identify clones with inserts of correct sizes.", "No less than five single colonies with inserts of correct sizes were sequenced for each antibody fragment.", "Five single colonies with correct VH and VL insert sizes were sent for sequencing.", "The VH and VL genes of five different clones were found to be nearly identical.", "The consensus sequences of the antibody produced by the hybridoma anti human TL1A clone 1A9, are: Heavy chain: DNA sequence (423 bp) (nucleotides encoding the three CDR sequences are underlined): (SEQ ID NO: 33) CAGATCCAGTTGGTACAGTCTGGACCTGAGCTGAAGAAGCCCGGAGAGAC AGTCAAGATCTCCTGCAAGGCTTCTGGGTATACCTTCACAACCTATGGAA TGAGCTGGGTGAAACAGGCGCCAGGAAAGGGTTTAAAGTGGATGGGCTGG ATGAACACCTACTCTGGAGTGACGACTTATGCTGATGACTTCAAGGGACG GTTTGCCTTCTCTTTGGAAACGTCTGCCAGTACTGCCTATATGCAGATCG ACAACCTCAAAAATGAAGACACGGCTACATATTTCTGTGCAAGAGAGGGG TATGTTTTCGACGACTACTATGCTACGGACTACTGGGGTCAAGGAACCTC AGTCACCGTCTCCTCA Heavy chain: Amino acids sequence (141 AA) (the three CDR sequences are underlined): (SEQ ID NO: 34) QIQLVQSGPELKKPGETVKISCKASGYTFTTYGMSWVKQAPGKGLKWMGW MNTYSGVTTYADDFKGRFAFSLETSASTAYMQIDNLKNEDTATYFCAREG YVFDDYYATDYWGQGTSVTVSS Light chain: DNA sequence (393 bp) (nucleotides encoding the three CDR sequences are underlined): (SEQ ID NO: 41) GATGTTTTGATGACCCAAACTCCACTCTCCCTGCCTGTCAGTCTTGGAGA TCAAGCCTCCATCTCTTGCAGATCTAGTCAGAACATTGTACATAGTGATG GAAACACCTATTTAGAATGGTACCTGCAGAAACCAGGCCAGTCTCCAAAA CTCCTGATCTACAAAGTTTCCAACCGATTTTCTGGGGTCCCAGACAGGTT CAGTGGCAGTGGATCCGGGACAGATTTCACACTCAAGATCAGCAGAGTGG AGGCTGAGGATCTGGGAATTTATTACTGCTTTCAAGGTTCACATGTTCCG CTCACGTTCGGTGCTGGGACCAAGCTGGAGCTGAAA Light chain: Amino acids sequence (131 AA) (the three CDR sequences are underlined): (SEQ ID NO: 42) DVLMTQTPLSLPVSLGDQASISCRSSQNIVHSDGNTYLEWYLQKPGQSPK WYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGIYYCFQGSHVPLT FGAGTKLELK H. 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Patent_15872592
[ [ "PROCESSES FOR PACKAGING OLIGONUCLEOTIDES INTO VIRUS-LIKE PARTICLES OF RNA BACTERIOPHAGES", "The invention provides processes for the producing compositions comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle.", "The invention further provides processes for producing nucleotide compositions comprising oligonucleotides suitable to be used in the processes mentioned before.", "The invention further provides nucleotide compositions obtainable by the processes of the invention and uses thereof.", "The invention further provides compositions comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, wherein said compositions are obtainable by the processes of the invention and wherein said compositions preferably comprises a purity of at least 98%, most preferably of at least 99%." ], [ "1-48.", "(canceled) 49.A composition obtainable by a process comprising: (a) providing coat protein of said RNA bacteriophage; (b) providing an oligonucleotide, (i) wherein said oligonucleotide at least one poly G stretch; and (ii) wherein said oligonucleotide comprise a relative peak start time of 50 to 110%; (c) generating a mixture, wherein said mixture comprises: (i) said coat protein; (ii) an agent capable of preventing the self-assembly of said coat protein; (iii) said oligonucleotide; (d) removing said agent from said mixture; and (e) allowing said coat protein to self assemble into a virus-like particle; said composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle.", "50.The composition of claim 49, wherein said RNA bacteriophage is bacteriophage Qβ, bacteriophage AP205, bacteriophage fr or bacteriophage GA, wherein preferably said RNA bacteriophage is bacteriophage Qβ.", "51.The composition of claim 49, wherein said oligonucleotide has the nucleic acid sequence “G8-8” GGGGGGGGGACGATCGTCGGGGGGGG (SEQ ID NO:6) or “G10” GGGGGGGGGG GACGATCGTC GGGGGGGGGG (SEQ ID NO:8), wherein preferably said oligonucleotide has the nucleic acid sequence “G10” GGGGGGGGGG GACGATCGTC GGGGGGGGGG (SEQ ID NO:8).", "52.The composition of claim 49, wherein the purity of said composition is at least 80%, preferably at least 90%, more preferably at least 95%, still more preferably at least 98%, and most preferably at least 99%.", "53.The composition of claim 49, wherein said oligonucleotide is not accessible to DNAse hydrolysis." ], [ "<SOH> FIELD OF THE INVENTION <EOH>The invention provides processes for the producing compositions comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle.", "The invention further provides processes for producing nucleotide compositions comprising oligonucleotides suitable to be used in the processes mentioned before.", "The invention further provides nucleotide compositions obtainable by the processes of the invention and uses thereof.", "The invention further provides compositions comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, wherein said compositions are obtainable by the processes of the invention and wherein said compositions preferably comprises a purity of at least 98%, most preferably of at least 99%." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The invention relates to a process for producing a nucleotide composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle.", "During said process said virus-like particle is formed by self assembly of coat protein of said RNA bacteriophage in the presence of an oligonucleotide.", "It has surprisingly been found that the efficiency of process can be significantly improved when the self assembly of the coat protein is performed in the presence of aggregated oligonucleotide.", "Generally, oligonucleotides comprising at least one poly G stretch are capable of aggregation.", "The aggregation state of an oligonucleotide can be characterized by the relative peak start time in size exclusion HPLC using the capsid of said RNA bacteriophage as standard.", "Oligonucleotide comprising a relative peak start time of 50 to 110%, preferably of 80 to 95%, has been found to be optimal.", "This corresponds to oligonucleotide aggregates comprising an apparent molecular weight which is in the range of the apparent molecular weight of the capsid of said RNA bacteriophage or slightly below.", "It has been found that oligonucleotide comprising the desired relative peak start time can be obtained by subjecting said oligonucleotide to an aggregation process.", "Thus, a first aspect of the invention is a process for producing a nucleotide composition comprising an oligonucleotide, wherein preferably said oligonucleotide comprises a relative peak start time of 50 to 110%, said process comprising the steps of: (a) providing an oligonucleotide in a solution II, wherein said oligonucleotide at least one poly G stretch; and wherein said solution II comprises a pH of 5 to 8; and wherein said solution II comprises a cation, wherein preferably the concentration of said cation in said solution II is at least 20 mM, wherein said cation is preferably selected from the group consisting of Na + , K + , NH 4 + , Li + , Ca 2+ , and Mg 2+ ; (b) adjusting the temperature of solution II to temperature III wherein said temperature III is 50 to 99° C.; and (c) incubating said oligonucleotide in solution II at temperature III, wherein said incubating is performed until said oligonucleotide comprises a relative peak start time of 50 to 110%; and (d) adjusting the temperature of solution II to temperature IV, wherein said temperature IV is below 50° C.; wherein said steps are preferably performed in the given order.", "The self assembly of said coat protein is most efficient when the oligonucleotide preparation comprises aggregates comprising the optimal particle size and a narrow size distribution.", "Further surprisingly it has been found that the aggregation state of the oligonucleotide can be controlled more efficiently and that oligonucleotide preparations with a more narrow size distribution are obtained, when the oligonucleotide is subjected to a disaggregation step prior to the aggregation step.", "Said process may comprise any one of the features and embodiments described herein in any combination.", "Thus, a second aspect of the invention is a process for producing a nucleotide composition comprising an oligonucleotide, wherein preferably said oligonucleotide comprises a relative peak start time of 50 to 110%, said process comprising the steps of: (a) providing an oligonucleotide in solution I, wherein said oligonucleotide at least one poly G stretch; and wherein said solution I comprises an alkaline pH; (b) disaggregating said oligonucleotide, wherein said disaggregating comprises the steps of: (i) adjusting the temperature of solution I to temperature I, wherein said temperature I is 4 to 70° C.; (ii) incubating said oligonucleotide in said solution I at said temperature I, wherein said incubating is performed until said oligonucleotide comprises a relative peak start time above 110%; and (iii) adjusting the temperature of said solution I to temperature II, wherein said temperature II is 0 to 70° C.; (c) adjusting the pH of said solution I to pH 5 to 8; and (d) aggregating said oligonucleotide, wherein said aggregating comprises the steps of: (i) providing said oligonucleotide in solution II, wherein said solution II comprises pH 5 to 8 and a cation, wherein preferably the concentration of said cation in said solution II is at least 20 mM, and wherein preferably said cation is selected from the group consisting of Na + , K + , NH 4 + , Li + , Ca 2+ , and Mg 2+ ; (ii) adjusting the temperature of solution II to temperature III, wherein said temperature III is 50 to 99° C.; (iii) incubating said oligonucleotide in solution II at temperature III, wherein said incubating is performed until said oligonucleotide comprises a relative peak start time of 50 to 110%; and (iv) adjusting the temperature of solution II to temperature IV, wherein said temperature IV is below 50° C.; wherein said steps are preferably performed in the given order.", "Said process may comprise any one of the features and embodiments described herein in any combination.", "A third aspect of the invention is a nucleotide composition comprising an oligonucleotide, wherein said nucleotide composition is obtainable by any one of the processes described above, wherein preferably said oligonucleotide comprises a relative peak start time of 50 to 110%.", "Said nucleotide composition may comprise any one of the features and embodiments described herein in any combination.", "A fourth aspect of the invention is a process for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, said process comprising the steps of: (a) providing coat protein of said RNA bacteriophage; (b) providing a nucleotide composition comprising an oligonucleotide, wherein said nucleotide composition is a nucleotide composition obtainable by any one of the processes of the first and the second aspect of the invention; (c) generating a mixture, wherein said mixture comprises: (i) said coat protein; (ii) an agent capable of preventing the self-assembly of said coat protein; (iii) said oligonucleotide; (d) removing said agent from said mixture; and (e) allowing said coat protein to self assemble into a virus-like particle.", "Said process may comprise any one of the features and embodiments described herein in any combination.", "A fifth aspect of the invention is a process for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, said process comprising the steps of: (a) providing coat protein of said RNA bacteriophage; (b) providing an oligonucleotide, (i) wherein said oligonucleotide at least one poly G stretch; and (ii) wherein said oligonucleotide comprise a relative peak start time of 50 to 110%; (c) generating a mixture, wherein said mixture comprises: (i) said coat protein; (ii) an agent capable of preventing the self-assembly of said coat protein; (iii) said oligonucleotide; (d) removing said agent from said mixture; and (e) allowing said coat protein to self assemble into a virus-like particle.", "Said process may comprise any one of the features and embodiments described herein in any combination.", "A sixth aspect of the invention is a process for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, said process comprising the steps of: (a) providing coat protein of said RNA bacteriophage; (b) providing an oligonucleotide, wherein preferably said oligonucleotide comprises a relative peak start time of 50 to 110%, said providing comprising the steps of: (i) providing an oligonucleotide in solution II, wherein said solution II comprises pH 5 to 8 and a cation, wherein preferably the concentration of said cation in said solution II is at least 20 mM, and wherein preferably said cation is selected from the group consisting of Na + , K + , NH 4 + , Li + , Ca 2+ , and Mg 2+ ; (ii) adjusting the temperature of solution II to temperature III wherein said temperature III is 50 to 99° C.; and (iii) incubating said oligonucleotide in solution II at temperature III, wherein said incubating is performed until said oligonucleotide comprises a relative peak start time of 50 to 110%; and (iv) adjusting the temperature of solution II to temperature IV, wherein said temperature IV is below 50° C.; wherein steps (i) to (iv) are preferably performed in the given order; (c) generating a mixture, wherein said mixture comprises: (i) said coat protein; (ii) an agent capable of preventing the self-assembly of said coat protein; (iii) said oligonucleotide; (d) removing said agent from said mixture; and (e) allowing said coat protein to self assemble into a virus-like particle.", "Said process may comprise any one of the features and embodiments described herein in any combination.", "A seventh aspect of the invention is a process for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, said process comprising the steps of: (a) providing coat protein of said RNA bacteriophage; (b) providing an oligonucleotide, wherein preferably said oligonucleotide comprises a relative peak start time of 50 to 110%, said providing comprising the steps of: (i) providing an oligonucleotide in solution I, wherein said oligonucleotide at least one poly G stretch; and wherein said solution I comprises an alkaline pH; (ii) disaggregating said oligonucleotide, wherein said disaggregating comprises the steps of: (1) adjusting the temperature of solution I to temperature I, wherein said temperature I is 4 to 70° C.; (2) incubating said oligonucleotide in said solution I at said temperature I, wherein said incubating is performed until said oligonucleotide comprises a relative peak start time above 110%; and (3) adjusting the temperature of said solution I to temperature II, wherein said temperature II is 0 to 70° C.; (iii) adjusting the pH of said solution I to pH 5 to 8; and (iv) aggregating said oligonucleotide, wherein said aggregating comprises the steps of: (1) providing said oligonucleotide in solution II, wherein said solution II comprises pH 5 to 8 and a cation, wherein preferably the concentration of said cation in said solution II is at least 20 mM, and wherein preferably said cation is selected from the group consisting of Na + , K + , NH 4 + , Li + , Ca 2+ , and Mg 2+ ; (2) adjusting the temperature of solution II to temperature III, wherein said temperature III is 50 to 99° C.; (3) incubating said oligonucleotide in solution II at temperature III, wherein said incubating is performed until said oligonucleotide comprises a relative peak start time of 50 to 110%; and (4) adjusting the temperature of solution II to temperature IV, wherein said temperature IV is below 50° C.; wherein steps (i) to (iv) are preferably performed in the given order; (c) generating a mixture, wherein said mixture comprises: (i) said coat protein; (ii) an agent capable of preventing the self-assembly of said coat protein; (iii) said oligonucleotide; (d) removing said agent from said mixture; and (e) allowing said coat protein to self assemble into a virus-like particle.", "Said process may comprise any one of the features and embodiments described herein in any combination.", "An eighth aspect of the invention is the use of a nucleotide composition obtainable by any one of the processes of the invention, in a process for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle.", "A ninth aspect of the invention is a composition obtainable by any one of the processes of the invention, said composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, wherein preferably said RNA bacteriophage is Qβ, and wherein further preferably said oligonucleotide is G8-8 (SEQ ID NO:6) or G10 (SEQ ID NO:8), preferably G10 (SEQ ID NO:8), and wherein still further preferably the purity of said composition is at least at least 98%, more preferably at least 99%, and most preferably at least 99.2%." ], [ "FIELD OF THE INVENTION The invention provides processes for the producing compositions comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle.", "The invention further provides processes for producing nucleotide compositions comprising oligonucleotides suitable to be used in the processes mentioned before.", "The invention further provides nucleotide compositions obtainable by the processes of the invention and uses thereof.", "The invention further provides compositions comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, wherein said compositions are obtainable by the processes of the invention and wherein said compositions preferably comprises a purity of at least 98%, most preferably of at least 99%.", "RELATED ART Virus-like particles of RNA bacteriophages packaged with oligonucleotides are potent stimulators of the immune system (WO2003/024481A2) and are widely used in modern vaccination treatments.", "Processes for producing compositions comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle have been described, for example, in WO2003/024481A2, WO2004/000351A1, WO2004/084940A1 and WO2004/007538A2.Processes which are based on the disassembly of a recombinant virus-like particle, the purification of the coat protein and the reassembly of said coat protein in the presence of nucleic acid are most commonly used.", "Efficient and scalable processes for the production of recombinant virus-like particles of RNA bacteriophages are disclosed in WO2005/117963A1.Processes for the large scale purification of endotoxin free, intact virus-like particles are disclosed in WO2007/039552A1.Processes for the preparation of coat protein from recombinantly produced virus like particles (“disassembly”) are disclosed, inter alia, in WO2003/024481A2, and in the examples section of the present application.", "The processes for the assembly of coat protein in the presence of nucleic acid (“reassembly”) disclosed in the prior are not optimized with respect to efficiency, scalability and purity of the assembled product.", "In particular, the prior art does not teach that the efficiency of the “reassembly” process, can be dramatically improved by using aggregated oligonucleotide comprising a certain particle size (herein characterized by the relative peak start time, see below).", "This application provides a “reassembly” process with dramatically enhanced efficiency leading to a packaging product of very high purity.", "Typically and preferably the “reassembly” process disclosed herein comprises a protein yield and an oligonucleotide yield of at least about 75% and results in a product (composition comprising a virus-like particle packaged with oligonucleotide) which typically and preferably is at least 99% pure.", "SUMMARY OF THE INVENTION The invention relates to a process for producing a nucleotide composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle.", "During said process said virus-like particle is formed by self assembly of coat protein of said RNA bacteriophage in the presence of an oligonucleotide.", "It has surprisingly been found that the efficiency of process can be significantly improved when the self assembly of the coat protein is performed in the presence of aggregated oligonucleotide.", "Generally, oligonucleotides comprising at least one poly G stretch are capable of aggregation.", "The aggregation state of an oligonucleotide can be characterized by the relative peak start time in size exclusion HPLC using the capsid of said RNA bacteriophage as standard.", "Oligonucleotide comprising a relative peak start time of 50 to 110%, preferably of 80 to 95%, has been found to be optimal.", "This corresponds to oligonucleotide aggregates comprising an apparent molecular weight which is in the range of the apparent molecular weight of the capsid of said RNA bacteriophage or slightly below.", "It has been found that oligonucleotide comprising the desired relative peak start time can be obtained by subjecting said oligonucleotide to an aggregation process.", "Thus, a first aspect of the invention is a process for producing a nucleotide composition comprising an oligonucleotide, wherein preferably said oligonucleotide comprises a relative peak start time of 50 to 110%, said process comprising the steps of: (a) providing an oligonucleotide in a solution II, wherein said oligonucleotide at least one poly G stretch; and wherein said solution II comprises a pH of 5 to 8; and wherein said solution II comprises a cation, wherein preferably the concentration of said cation in said solution II is at least 20 mM, wherein said cation is preferably selected from the group consisting of Na+, K+, NH4+, Li+, Ca2+, and Mg2+; (b) adjusting the temperature of solution II to temperature III wherein said temperature III is 50 to 99° C.; and (c) incubating said oligonucleotide in solution II at temperature III, wherein said incubating is performed until said oligonucleotide comprises a relative peak start time of 50 to 110%; and (d) adjusting the temperature of solution II to temperature IV, wherein said temperature IV is below 50° C.; wherein said steps are preferably performed in the given order.", "The self assembly of said coat protein is most efficient when the oligonucleotide preparation comprises aggregates comprising the optimal particle size and a narrow size distribution.", "Further surprisingly it has been found that the aggregation state of the oligonucleotide can be controlled more efficiently and that oligonucleotide preparations with a more narrow size distribution are obtained, when the oligonucleotide is subjected to a disaggregation step prior to the aggregation step.", "Said process may comprise any one of the features and embodiments described herein in any combination.", "Thus, a second aspect of the invention is a process for producing a nucleotide composition comprising an oligonucleotide, wherein preferably said oligonucleotide comprises a relative peak start time of 50 to 110%, said process comprising the steps of: (a) providing an oligonucleotide in solution I, wherein said oligonucleotide at least one poly G stretch; and wherein said solution I comprises an alkaline pH; (b) disaggregating said oligonucleotide, wherein said disaggregating comprises the steps of: (i) adjusting the temperature of solution I to temperature I, wherein said temperature I is 4 to 70° C.; (ii) incubating said oligonucleotide in said solution I at said temperature I, wherein said incubating is performed until said oligonucleotide comprises a relative peak start time above 110%; and (iii) adjusting the temperature of said solution I to temperature II, wherein said temperature II is 0 to 70° C.; (c) adjusting the pH of said solution I to pH 5 to 8; and (d) aggregating said oligonucleotide, wherein said aggregating comprises the steps of: (i) providing said oligonucleotide in solution II, wherein said solution II comprises pH 5 to 8 and a cation, wherein preferably the concentration of said cation in said solution II is at least 20 mM, and wherein preferably said cation is selected from the group consisting of Na+, K+, NH4+, Li+, Ca2+, and Mg2+; (ii) adjusting the temperature of solution II to temperature III, wherein said temperature III is 50 to 99° C.; (iii) incubating said oligonucleotide in solution II at temperature III, wherein said incubating is performed until said oligonucleotide comprises a relative peak start time of 50 to 110%; and (iv) adjusting the temperature of solution II to temperature IV, wherein said temperature IV is below 50° C.; wherein said steps are preferably performed in the given order.", "Said process may comprise any one of the features and embodiments described herein in any combination.", "A third aspect of the invention is a nucleotide composition comprising an oligonucleotide, wherein said nucleotide composition is obtainable by any one of the processes described above, wherein preferably said oligonucleotide comprises a relative peak start time of 50 to 110%.", "Said nucleotide composition may comprise any one of the features and embodiments described herein in any combination.", "A fourth aspect of the invention is a process for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, said process comprising the steps of: (a) providing coat protein of said RNA bacteriophage; (b) providing a nucleotide composition comprising an oligonucleotide, wherein said nucleotide composition is a nucleotide composition obtainable by any one of the processes of the first and the second aspect of the invention; (c) generating a mixture, wherein said mixture comprises: (i) said coat protein; (ii) an agent capable of preventing the self-assembly of said coat protein; (iii) said oligonucleotide; (d) removing said agent from said mixture; and (e) allowing said coat protein to self assemble into a virus-like particle.", "Said process may comprise any one of the features and embodiments described herein in any combination.", "A fifth aspect of the invention is a process for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, said process comprising the steps of: (a) providing coat protein of said RNA bacteriophage; (b) providing an oligonucleotide, (i) wherein said oligonucleotide at least one poly G stretch; and (ii) wherein said oligonucleotide comprise a relative peak start time of 50 to 110%; (c) generating a mixture, wherein said mixture comprises: (i) said coat protein; (ii) an agent capable of preventing the self-assembly of said coat protein; (iii) said oligonucleotide; (d) removing said agent from said mixture; and (e) allowing said coat protein to self assemble into a virus-like particle.", "Said process may comprise any one of the features and embodiments described herein in any combination.", "A sixth aspect of the invention is a process for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, said process comprising the steps of: (a) providing coat protein of said RNA bacteriophage; (b) providing an oligonucleotide, wherein preferably said oligonucleotide comprises a relative peak start time of 50 to 110%, said providing comprising the steps of: (i) providing an oligonucleotide in solution II, wherein said solution II comprises pH 5 to 8 and a cation, wherein preferably the concentration of said cation in said solution II is at least 20 mM, and wherein preferably said cation is selected from the group consisting of Na+, K+, NH4+, Li+, Ca2+, and Mg2+; (ii) adjusting the temperature of solution II to temperature III wherein said temperature III is 50 to 99° C.; and (iii) incubating said oligonucleotide in solution II at temperature III, wherein said incubating is performed until said oligonucleotide comprises a relative peak start time of 50 to 110%; and (iv) adjusting the temperature of solution II to temperature IV, wherein said temperature IV is below 50° C.; wherein steps (i) to (iv) are preferably performed in the given order; (c) generating a mixture, wherein said mixture comprises: (i) said coat protein; (ii) an agent capable of preventing the self-assembly of said coat protein; (iii) said oligonucleotide; (d) removing said agent from said mixture; and (e) allowing said coat protein to self assemble into a virus-like particle.", "Said process may comprise any one of the features and embodiments described herein in any combination.", "A seventh aspect of the invention is a process for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, said process comprising the steps of: (a) providing coat protein of said RNA bacteriophage; (b) providing an oligonucleotide, wherein preferably said oligonucleotide comprises a relative peak start time of 50 to 110%, said providing comprising the steps of: (i) providing an oligonucleotide in solution I, wherein said oligonucleotide at least one poly G stretch; and wherein said solution I comprises an alkaline pH; (ii) disaggregating said oligonucleotide, wherein said disaggregating comprises the steps of: (1) adjusting the temperature of solution I to temperature I, wherein said temperature I is 4 to 70° C.; (2) incubating said oligonucleotide in said solution I at said temperature I, wherein said incubating is performed until said oligonucleotide comprises a relative peak start time above 110%; and (3) adjusting the temperature of said solution I to temperature II, wherein said temperature II is 0 to 70° C.; (iii) adjusting the pH of said solution I to pH 5 to 8; and (iv) aggregating said oligonucleotide, wherein said aggregating comprises the steps of: (1) providing said oligonucleotide in solution II, wherein said solution II comprises pH 5 to 8 and a cation, wherein preferably the concentration of said cation in said solution II is at least 20 mM, and wherein preferably said cation is selected from the group consisting of Na+, K+, NH4+, Li+, Ca2+, and Mg2+; (2) adjusting the temperature of solution II to temperature III, wherein said temperature III is 50 to 99° C.; (3) incubating said oligonucleotide in solution II at temperature III, wherein said incubating is performed until said oligonucleotide comprises a relative peak start time of 50 to 110%; and (4) adjusting the temperature of solution II to temperature IV, wherein said temperature IV is below 50° C.; wherein steps (i) to (iv) are preferably performed in the given order; (c) generating a mixture, wherein said mixture comprises: (i) said coat protein; (ii) an agent capable of preventing the self-assembly of said coat protein; (iii) said oligonucleotide; (d) removing said agent from said mixture; and (e) allowing said coat protein to self assemble into a virus-like particle.", "Said process may comprise any one of the features and embodiments described herein in any combination.", "An eighth aspect of the invention is the use of a nucleotide composition obtainable by any one of the processes of the invention, in a process for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle.", "A ninth aspect of the invention is a composition obtainable by any one of the processes of the invention, said composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, wherein preferably said RNA bacteriophage is Qβ, and wherein further preferably said oligonucleotide is G8-8 (SEQ ID NO:6) or G10 (SEQ ID NO:8), preferably G10 (SEQ ID NO:8), and wherein still further preferably the purity of said composition is at least at least 98%, more preferably at least 99%, and most preferably at least 99.2%.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1: Size exclusion HPLC chromatogram of the Qβ capsid standard (top) and aggregated G10 (bottom).", "HPLC was performed as described in Example 4.The retention time of the standard was 8.532 min, the peak start time of aggregated G10 was 7.510 min.", "Thus, the relative peak start time of the aggregated G10 was 88% (7.510 min/8.532 min*100).", "FIG.", "2: Size exclusion HPLC chromatogram of untreated G10, aggregated oligonucleotide G10 and Qβ capsid standard.", "HPLC was performed as described in Example 4 (A) Aggregated G10 that was not subjected to a disaggregation treatment prior to aggregation showed an equivalent or higher apparent molecular weight than Qβ capsid (A, box 2).", "The relative peak start time was ca.", "75%.", "(B) Aggregated G10 which prior to aggregation was subjected to a disaggregation treatment as described in Example 1 exhibited a lower apparent molecular weight than Qβ capsid (B, box 2).", "The relative peak start time was ca.", "88%.", "FIG.", "3: CD spectra of untreated, disaggregated and aggregated G10 oligonucleotide and reassembled VLP packed with G10.Spectra were recorded using oligonucleotide concentrations of 22.5 μM and subsequently normalized.", "For normalization, ellipticities are calculated according to □=100×CD signal [mdeg]/L [cm]×c [mM].", "FIG.", "4: Characterization of purified Qβ coat protein by analytical size exclusion chromatography.", "(A) sample of purified Qβ VLP.", "The observed peak (ratio A260/A280=2) is dominated by the RNA core of the VLP, because the absorption coefficient of RNA at 260 nm is approx.", "100 fold higher than the absorption coefficient of the coat protein.", "(B) sample of the supernatant of the disassembly reaction.", "Released coat protein is indicated by the presence of the protein-like peak at approx.", "12 min.", "Furthermore several species of non-precipitated RNA molecules are present in the range 6.8 to 11 min.", "(C) sample of purified Qβ coat protein.", "Analysis was performed in PBS on column TSK G5000PWx1 (Tosoh Bioscience).", "FIG.", "5: Analytical size exclusion chromatography of (A) native Qβ VLP, (D) QβG10 VLP and the packaging components (B) oligo nucleotide G10 and (C) Qβ coat protein.", "The observed peak for QβG10 VLP (D) (ratio A260/A280=1.74) is dominated by the G10 core of the VLP, because the absorption coefficient of G10 at 260 nm is approx.", "130 fold higher than the absorption coefficient of the coat protein.", "Analysis was performed in PBS on column TSK G5000PWx1 (Tosoh Bioscience).", "FIG.", "6: Non-reducing SDS-PAGE analysis of native Qβ VLP and in vitro assembled QβG10.The position of the coat protein pentamers and hexamers is indicated ((a) molecular weight marker, (b) Qβ VLP, (c) Qβ G10).", "DETAILED DESCRIPTION OF THE INVENTION The definitions and embodiments described in the following are, unless explicitly stated otherwise, applicable to any one of the aspects, and embodiments, in particular processes, compositions, nucleotide compositions and uses of the invention.", "Unless defined otherwise, all technical and scientific terms used herein have the same meanings as commonly understood by one of ordinary skill in the art to which this invention belongs.", "“oligonucleotide”: The term oligonucleotide as used herein refers to a single stranded deoxyribonucleotide.", "A preferred oligonucleotide comprises at least one poly G stretch as defined below.", "More preferred oligonucleotides comprise 2, 3, 4, 5, 6, 7, 8, 9, or 10 of said poly G stretches.", "Very preferred oligonucleotides comprise exactly two poly G stretches, wherein preferably one of said two poly G stretches is located at the 5′ end or at the 3′ end of said oligonucleotide.", "Even more preferred oligonucleotides comprise exactly two poly G stretches, wherein one of said two poly G stretches is located at the 5′ end of said oligonucleotide and one of said two poly G stretches is located at the 3′ end of said oligonucleotide.", "Typically and preferably, an oligonucleotide as used herein consists of 6 to 1000, preferably of 10 to 1000, more preferably of 10 to 200, still more preferably of 10 to 100, still more preferably of 20 to 40, and most preferably of 30 nucleotides.", "Further preferred oligonucleotides consist of 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40 nucleotides.", "Still more preferred oligonucleotides consists of 24 to 32 nucleotides, more preferably of about 30 nucleotides.", "The term oligonucleotide also refers to molecules comprising at least one modified nucleotide, wherein preferably said modified nucleotide is selected from (a) a nucleotide analogue or (b) a nucleotide comprising a backbone modification.", "In one embodiment the oligonucleotide comprises at least one modified nucleotide selected from the group consisting of (a) peptide nucleic acid, (b) inosin, (c) tritylated bases, (d) phosphorothioates, (e) alkylphosphorothioates, (f) 5-nitroindole desoxyribofuranosyl, (g) 5-methyldesoxycytosine, and (h) 5,6-dihydro-5,6-dihydroxydesoxythymidine.", "In a further embodiment the oligonucleotide comprises or alternatively consists of phosphothioated nucleotides.", "Phosphothioated nucleotides are protected against degradation in a cell or an organism and are therefore preferred nucleotide modifications.", "Further preferred are chemically, enzymatically or metabolically modified forms of polynucleotides as typically found in nature.", "However, preferred oligonucleotides exclusively consists of unmodified nucleotides, i.e.", "of adenosine, tymidine, guanosine, and/or cytidine.", "Still further preferred oligonucleotides exclusively consists of phosphodiester bound nucleotides.", "Very preferred oligonucleotides are unmethylated CpG containing oligonucleotides comprising at least one, preferably one, two, three or four CpG motifs.", "Still more preferred oligonucleotides comprise a palindromic sequence, wherein preferably said palindromic sequence comprises least one, preferably one, two, three or four CpG motifs.", "Still more preferred oligonucleotides comprise a palindromic sequence, wherein preferably said palindromic sequence comprises, or preferably consists of the sequence GACGATCGTC (SEQ ID NO:1).", "Still more preferred oligonucleotides comprise a palindromic sequence, wherein said palindromic sequence is flanked at its 5′ end by a poly G stretch and wherein said palindromic sequence is flanked at its 3′ end by a poly G stretch, wherein preferably said palindromic sequence is GACGATCGTC (SEQ ID NO:1).", "Very preferred oligonucleotides comprise a palindromic sequence, wherein said palindromic sequence is flanked at its 5′ end by at least 3 to 10, preferably by 4 to 10 guanosine entities and wherein said palindromic sequence is flanked at its 3′ end at least 3 to 10, preferably by 4 to 10, guanosine entities, wherein preferably said palindromic sequence is GACGATCGTC (SEQ ID NO:1).", "“poly G stretch”: The term poly G stretch relates to a segment of an oligonucleotide, wherein said segment consists of at least 3 consecutive guanosine residues.", "Preferred poly G stretches consist of 3 to 25, preferably of 4 to 20, more preferably of 4 to 15 and most preferably of 4 to 10 consecutive guanosine entities.", "Further preferred poly G stretches consist of 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 consecutive guanosine entities.", "“CpG motif”: As used herein, the term “CpG motif” refers to short DNA sequence, preferably a single stranded DNA sequence, comprising a cytosine (C)—guanosine (G) dinucleotide, wherein C is unmethylated and wherein preferably said CG dinucleotide is phosphodiester bound.", "Preferably, a CpG motif comprises at least one, preferably one, two or three, additional nucleotides 5′ and/or 3′ of said CG dinucleotide, wherein further preferably said additional nucleotides do not comprise a CG dinucleotide.", "“relative peak start time”: The term “relative peak start time” is a parameter which is indicative of the aggregation state of an oligonucleotide.", "The relative peak start time of an oligonucleotide is determined by analytical size exclusion HPLC, wherein preferably said HPLC is performed essentially with, preferably exactly with the following parameters: Column: TSKgel 5000 PWXL 7.8 mm*30.0 cm (Lot: 5PWX06GNMH3304, Art: 08023, Tosoh Bioscience) Eluent: PBS (150 mM NaCl in 20 mM sodium phosphate buffer, pH 7.2) Injection volume: 40.0 μl (preferably comprising a concentration of about 20 μM to about 500 μM) Flow rate: 0.8 ml/min Gradient: Isocratic Run time: 20 min Wavelength: 215, 260 and 280 nm, data evaluation at 260 nm Column oven temp.", ": 25° C. Autosampler temp.", ": 8° C.; and wherein the capsid of said RNA bacteriophage is used as a standard.", "The relative peak start time X % of said oligonucleotide relative to the capsid of said RNA bacteriophage is calculated as follows: X %=peak start time [min] of the oligonucleotide divided by the retention time of the standard [min]×100%, wherein the peak start time of the oligonucleotide is determined as the time when the elution of the oligonucleotide becomes detectable, and wherein the retention time of the standard is determined as the time of the occurrence of the maximum peak of said standard.", "Thus, in an embodiment wherein said RNA bacteriophage is, for example, bacteriophage AP205, capsid of AP205 is used as standard in said HPLC and the relative peak start time of said oligonucleotide is calculated relative to said AP205 standard.", "Importantly, in embodiments which do not refer to an RNA bacteriophage, the relative peak start time is always determined by using the capsid of bacteriophage Qβ as standard.", "Furthermore, in case of any uncertainty regarding the choice of the appropriate standard in said HPLC, capsid of bacteriophage Qβ is used as standard and the relative peak start time is determined relative to said capsid of bacteriophage Qβ.", "Thus, in a very preferred embodiment said relative peak start time is determined by said HPLC, wherein preferably said standard is capsid of bacteriophage Qβ, and wherein further preferably said relative peak start time is determined relative to said capsid of bacteriophage Qβ.", "“packaged”: The term “packaged” as used herein refers to the state of an oligonucleotide, in relation to the virus-like particle.", "The use of the terms “oligonucleotide packaged into VLP” or “VLP packaged with oligonucleotide” is equivalent.", "The term “packaged” as used herein refers to non-covalent binding, preferably to ionic interactions, hydrophobic interactions, or hydrogen bonds.", "Very preferably, the term “packaged” as used herein refers to the enclosement, or partial enclosement, of said oligonucleotide within the VLP.", "For example, the oligonucleotide, preferably the oligonucleotide comprising a relative peak start time of 50 to 110%, can be enclosed by the VLP without the existence of an actual binding, neither covalently nor non-covalently, or with a non-covalent binding.", "Typically and preferably, a VLP packaged with oligonucleotide protects said oligonuclaotide from degradation, preferably from DNAse hydrolysis.", "Therefore, in the preferred meaning, the term “packaged” indicates that the oligonucleotide in a packaged state is not accessible to DNAse hydrolysis.", "More preferably, the term “packaged” indicates that the oligonucleotide is not accessible to DNAse hydrolysis, wherein further preferably the DNAse is DNAseI or Benzonase.", "Still more preferably, the term “packaged” indicates that the oligonucleotide is not accessible to Benzonase hydrolysis.", "The accessibility of the oligonucleotide for DNAse (e.g.", "DNaseI or Benzonase) is preferably assayed as described in Examples 11-17 of WO2003/024481A2 (see p. 111 therein).", "In a preferred meaning, a VLP is regarded as being packaged with an oligonucleotide, when after treatment with Benzonase (190 U Benzonase/mg coat protein in a buffer comprising 2 mM MgCl2, pH 7.2, 20-25° C., 18 h) at least 90%, preferably at least 95%, most preferably at least 98% of said oligonucleotide can be recovered from said VLP (e.g.", "in an ethidiumbromide stained gel).", "It is apparent for the artisan that such assays require appropriate controls and may need to be adapted to the specific combination of VLP and oligonucleotide.", "In a more preferred meaning, an oligonucleotide is regarded as being packaged into a VLP of an RNA bacteriophage, when after treatment with Benzonase (190 U Benzonase/mg coat protein in a buffer comprising 2 mM MgCl2, pH 7.2, 20-25° C., 18 h) at least 90%, preferably at least 95%, most preferably at least 98% of said oligonucleotide can be recovered from said VLP of an RNA bacteriophage.", "In a very preferred meaning, oligonucleotide G10 (SEQ ID NO:8) is regarded as being packaged into a VLP of an RNA bacteriophage, when after treatment with Benzonase (190 U Benzonase/mg coat protein in a buffer comprising 2 mM MgCl2, pH 7.2, 20-25° C., 18 h) at least 90%, preferably at least 95%, most preferably at least 98% of said G10 can be recovered from said VLP.", "In more specific meaning, oligonucleotide G10 (SEQ ID NO:8) is regarded as being packaged into a VLP of a RNA bacteriophage Qβ, AP205, GA or fr, when after treatment with Benzonase (190 U Benzonase/mg coat protein in a buffer comprising 2 mM MgCl2, pH 7.2, 20-25° C., 18 h) at least 90%, preferably at least 95%, most preferably at least 98% of said G10 can be recovered from said VLP of an RNA bacteriophage.", "In a very specific meaning, oligonucleotide G10 (SEQ ID NO:8) is regarded as being packaged into a VLP of a RNA bacteriophage Qβ, when after treatment with Benzonase (190 U Benzonase/mg coat protein in a buffer comprising 2 mM MgCl2, pH 7.2, 20-25° C., 18 h) at least 90%, preferably at least 95%, most preferably at least 98% of said unmethylated CpG-containing oligonucleotide can be recovered from said VLP of RNA bacteriophage Qβ.", "“coat protein”: As used herein, the term “coat protein” refers to the protein(s) of a RNA bacteriophage capable of being incorporated within the capsid assembly of the bacteriophage or the RNA bacteriophage.", "Thus, the term coat protein refers to the protein forming the capsid of a RNA bacteriophage or a VLP of a RNA bacteriophage.", "Typically and preferably, coat protein of RNA bacteriophages has a dimeric structure.", "“fragment of a (recombinant) coat protein”, in particular fragment of a recombinant coat protein, as used herein, is defined as a polypeptide, which is of at least 70%, preferably at least 80%, more preferably at least 90%, even more preferably at least 95% the length of the wild-type coat protein, or wild type recombinant protein, respectively and which preferably retains the capability of forming VLP.", "Preferably the fragment is obtained by at least one internal deletion, at least one truncation or at least one combination thereof.", "The term “fragment of a recombinant coat protein” or “fragment of a coat protein” shall further encompass polypeptide, which has at least 80%, preferably 90%, even more preferably 95% amino acid sequence identity with the wildtype coat protein, respectively, and which is preferably capable of assembling into a virus-like particle.", "The term “mutant coat protein” refers to a polypeptide having an amino acid sequence derived from the wild type recombinant protein, or coat protein, respectively, wherein the amino acid sequence is at least 80%, preferably at least 85%, 90%, 95%, 97%, or 99% identical to the wild type sequence and preferably retains the ability to assemble into a VLP.", "“virus-like particle (VLP)”, as used herein, refers to a non-replicative or non-infectious, preferably a non-replicative and non-infectious virus particle, or refers to a non-replicative or non-infectious, preferably a non-replicative and non-infectious structure resembling a virus particle, preferably a capsid of a virus.", "The term “non-replicative”, as used herein, refers to being incapable of replicating the genome comprised by the VLP.", "The term “non-infectious”, as used herein, refers to being incapable of entering the host cell.", "Preferably a virus-like particle in accordance with the invention is non-replicative and/or non-infectious since it lacks all or part of the viral genome or genome function.", "In one embodiment, a virus-like particle is a virus particle, in which the viral genome has been physically or chemically inactivated, removed by disassembly and reassembly, or by assembly of purified proteins into a VLP.", "Typically and more preferably a virus-like particle lacks all or part of the replicative and infectious components of the viral genome.", "A virus-like particle in accordance with the invention may contain nucleic acid distinct from their genome.", "A typical and preferred embodiment of a virus-like particle in accordance with the present invention is a viral capsid such as the viral capsid of the corresponding virus, bacteriophage, preferably RNA bacteriophage.", "The term “capsid”, refers to a macromolecular assembly composed of viral protein subunits.", "Typically, there are 60, 120, 180, 240, 300, 360 and more than 360 viral protein subunits.", "Typically and preferably, the interactions of these subunits lead to the formation of viral capsid with an inherent repetitive organization, wherein said structure typically and preferably is spherical.", "For example, the capsids of RNA bacteriophages have a spherical form of icosahedral symmetry.", "“virus-like particle of an RNA bacteriophage”: As used herein, the term “virus-like particle of a RNA bacteriophage” refers to a virus-like particle comprising, or preferably consisting essentially of or consisting of coat proteins, mutants or fragments thereof, of a RNA bacteriophage.", "In addition, virus-like particle of a RNA bacteriophage resembling the structure of a RNA bacteriophage, being non replicative and/or non-infectious, and lacking at least the gene or genes encoding for the replication machinery of the RNA bacteriophage, and typically also lacking the gene or genes encoding the protein or proteins responsible for viral attachment to or entry into the host.", "Preferred VLPs derived from RNA bacteriophages exhibit icosahedral symmetry and consist of 180 subunits.", "In the context of the invention the term virus-like particle of an RNA bacteriophage preferably relates to a macromolecular structure obtained by the self-assembly of recombinant coat protein of an RNA bacteriophage, or fragments or mutants thereof, wherein preferably said self-assembly took place in the presence of and oligonucleotide.", "“agent capable of preventing the self assembly of coat protein”: An agent capable of preventing the self assembly of coat protein is an agent which prevents the spontaneous formation of virus-like particles in said mixture.", "The artisan is able to determine the chemical nature and the appropriate concentration of said agent experimentally, e.g.", "by analyzing said mixture by size exclusion chromatography as disclosed in Example 9.An agent is capable of preventing the self assembly of coat protein, when after incubation of said mixture for at least 1 h at room temperature, preferably at 22° C., no virus-like particle is detectable by the size exclusion chromatography disclosed in Example 9.However, agent which is capable of preventing the self assembly of coat protein, does not irreversibly modify said coat protein and removing said agent from said mixture will result in the spontaneous formation of virus-like particles.", "Preferred agents capable of preventing the self assembly of coat protein comprise detergents, guanidiniumhydrochloride and urea, most preferably urea.", "Preferred detergents are sodiumdodecylsulfate, Tween 20, TritonX 100 and the like.", "Typically and preferably agents capable of preventing the self assembly of coat protein further comprise a reducing agent which keeps intermolecular disulfide bounds formed by cystein residues of said coat protein in a reduced state.", "“protein yield”: The protein yield of a process of the invention is determined as the amount of coat protein recovered as virus-like particle after the last step of said process relative to the amount of coat protein contained in said mixture, wherein preferably the amount of said coat protein is determines by Bradford protein assay.", "Typically and preferably at least 70%, preferably at least 75% of the coat protein contained in said mixture is recovered as virus-like particle after the final step of said process, wherein preferably said final step is said sterile filtrating.", "“oligonucleotide yield”: The oligonucleotide yield of a process of the invention is determined as the amount of oligonucleotide that can be recovered from said virus-like particle after the last step of said process relative to the amount of said oligonucleotide contained in said mixture, wherein preferably the amount of said oligonucleotide recovered from said virus-like particle is determined essentially or preferably exactly as disclosed in Example 9.Typically and preferably at least 70%, preferably at least 75% of the oligonucleotide contained in said mixture is recovered from said virus-like particle after the final step of said process, wherein preferably said final step is said sterile filtrating.", "“purity”: The purity of a composition of the invention comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, is determined by analytic size exclusion HPLC, wherein said HPLC is performed under conditions essentially, preferably exactly as disclosed in Example 4.The purity of said composition is determined as the percentage of the peak area of said virus-like particle contained in said composition relative to the total peak area of the same chromatogram.", "Typically and preferably the purity of a composition of the invention is at least 98%, preferably at least 99%.", "“one”, “a/an”: When the terms “one,” “a,” or “an” are used in this disclosure, they mean “at least one” or “one or more,” unless otherwise indicated.", "“about”: within the meaning of the present application the expression about shall have the meaning of +/−10%.", "For example about 100 shall mean 90 to 110.The invention provides processes for producing a nucleotide composition comprising an aggregated oligonucleotide.", "In more detail, the invention provides a process for producing a nucleotide composition comprising an oligonucleotide, wherein preferably said oligonucleotide comprises a relative peak start time of 50 to 110%, said process comprising the steps of: (a) providing an oligonucleotide in a solution II, wherein said oligonucleotide preferably comprises at its 5′ end at least 3 guanosine entities and at its 3′ end at least 3 guanosine entities; and wherein said solution II comprises a pH of 5 to 8; and wherein said solution II comprises a cation, wherein preferably the concentration of said cation in said solution II is at least 20 mM, wherein said cation is preferably selected from the group consisting of Na+, K+, NH4+, Li+, Ca2+, and Mg2+; (b) adjusting the temperature of solution II to temperature III wherein said temperature III is 50 to 99° C.; and (c) incubating said oligonucleotide in solution II at temperature III, wherein said incubating is performed until said oligonucleotide comprises a relative peak start time of 50 to 110%; and (d) adjusting the temperature of solution II to temperature IV, wherein said temperature IV is below 50° C.; wherein said steps are preferably performed in the given order.", "All embodiments described in the following are applicable to this process in any combination.", "As mentioned above, it was found that it is advantages to subject said oligonucleotide to a disaggregation step prior to said aggregation step, wherein preferably said oligonucleotide is completely disaggregated.", "Complete disaggregation of the oligonucleotide means that the apparent molecular weight of the oligonucleotide in size exclusion HPLC, preferably carried out essentially as described in Example 4, corresponds to the molecular weight which can be derived from the sequence of said oligonucleotide.", "Thus, the invention further provides a process for producing a nucleotide composition comprising an oligonucleotide, wherein preferably said oligonucleotide comprises a relative peak start time of 50 to 110%, said process comprising the steps of: (a) providing an oligonucleotide in solution I, wherein said oligonucleotide at least one poly G stretch; and wherein said solution I comprises an alkaline pH; (b) disaggregating said oligonucleotide, wherein said disaggregating comprises the steps of: (i) adjusting the temperature of solution I to temperature I, wherein said temperature I is 4 to 70° C.; (ii) incubating said oligonucleotide in said solution I at said temperature I, wherein said incubating is performed until said oligonucleotide comprises a relative peak start time above 110%; and (iii) adjusting the temperature of said solution I to temperature II, wherein said temperature II is 0 to 70° C.; (c) adjusting the pH of said solution I to pH 5 to 8; and (d) aggregating said oligonucleotide, wherein said aggregating comprises the steps of: (i) providing said oligonucleotide in solution II, wherein said solution II comprises pH 5 to 8 and a cation, wherein preferably the concentration of said cation in said solution II is at least 20 mM, and wherein preferably said cation is selected from the group consisting of Na+, K+, NH4+, Li+, Ca2+, and Mg2+; (ii) adjusting the temperature of solution II to temperature III, wherein said temperature III is 50 to 99° C.; (iii) incubating said oligonucleotide in solution II at temperature III, wherein said incubating is performed until said oligonucleotide comprises a relative peak start time of 50 to 110%; and (iv) adjusting the temperature of solution II to temperature IV, wherein said temperature IV is below 50° C.; wherein said steps are preferably performed in the given order.", "The disaggregation of untreated oligonucleotide which may comprise partially aggregated oligonucleotide occurs at alkaline pH.", "The disaggregation process can be facilitated by elevated temperature.", "Thus, in one embodiment solution I comprises a pH of 8 to 13, preferably 10 to 13, most preferably 12.Solution I may comprise any buffer or agent may comprise any buffer or agent known in the art which allows to adjust the pH between 8 and 13.In a preferred embodiment solution I comprises hydroxide, preferably a metal hydroxide, most preferably a hydroxide of an alkali metal or an earth alkaline metal, preferably a hydroxide of an alkali metal.", "In a preferred embodiment said hydroxide is potassium hydroxide or sodium hydroxide, most preferably sodium hydroxide.", "In one embodiment the concentration of said hydroxide, preferably of said sodium hydroxide, in said solution I is 10 mM to 200 mM, more preferably about 25 mM, most preferably 25 mM.", "To avoid degradation of the oligonucleotide, temperature I preferably does not exceed 90° C., temperature I does not exceed 70° C. In one embodiment temperature I is room temperature, preferably 19 to 25° C. In another embodiment temperature I is 4 to 70° C., preferably 20 to 70° C., more preferably 45 to 70° C., preferably about 50° C., and most preferably 50° C. In a preferred embodiment said incubating said oligonucleotide in said solution I at said temperature I is performed until said oligonucleotide is completely disaggregated.", "In another embodiment said incubating said oligonucleotide in said solution I at said temperature I is performed until the relative peak start time of said oligonucleotide is above 110%, preferably above 130% and most preferably above 135%.", "In a further embodiment said incubating said oligonucleotide in said solution I at said temperature I is performed for 30 to 190 min, preferably for 50 to 90 min, most preferably for 70 min.", "In a further preferred embodiment the concentration of said oligonucleotide in said solution I is 50 μM to 2 mM, preferably 50 to 500 μM, more preferably 200 to 300 μM, and most preferably 260 μM.", "The disaggregation of the oligonucleotide can be terminated by neutralizing or acidifying solution I and/or reducing the temperature.", "Thus, said process further comprises the step of adjusting the pH of said solution I to pH 8 or below, preferably to pH 5 to 8.In a preferred embodiment said adjusting of the pH is performed until said pH is 6 to 7, most preferably until said pH is about 6.In a further embodiment said adjusting of the pH of said solution I is performed by the addition of acid to said solution I.", "Any mineral or organic acid known in the art can be used for this purpose.", "In a preferred embodiment said acid is selected from the group consisting of phosphoric acid; hydrochloric acid; and organic acids, wherein said organic acids are preferably selected from formic acid, acetic acid, and citric acid.", "In a preferred embodiment said acid is a mineral acid.", "Preferably, said acid is phosphoric acid or hydrochloric acid, most preferably phosphoric acid.", "Said process further comprises adjusting the temperature of said solution I to temperature II, wherein preferably said temperature II is 0 to 70° C. and wherein preferably said temperature II is below temperature I.", "In a preferred embodiment said temperature II is 0 to 25° C., preferably 0 to 10° C., and most preferably 0 to 2° C. The process further comprises the step of aggregating said oligonucleotide.", "Aggregation of the oligonucleotide is achieved by incubating said oligonucleotide at about neutral pH in a solution comprising cations capable of supporting the formation of G-quadruplex DNA structures (cf.", "Simonsson T., Biol.", "Chem.", "382:621-628) and at a temperature above 50° C. Thus, in one embodiment said cation is selected from the group consisting of Na+, K+, Rb+, NH4+, Cs+, Li+, Sr2+, Ba2+, Ca2+, Mn2+, Co2+, Ni2+, and Mg2+.", "In a preferred embodiment said cation is selected from the group consisting of Na+, K+, NH4+, Li+, Ca2+, and Mg2+, more preferably said cation is Na+ or K+, most preferably said cation is Na+.", "In a very preferred embodiment the concentration In a preferred embodiment solution II comprising said oligonucleotide is obtained by the addition of said cation to said solution I, wherein preferably said addition is performed after said adjusting of the pH of solution I.", "In a further embodiment said solution II a mixture of any cation selected from the group consisting of Na+, K+, Rb+, NH4+, Cs+, Li+, Sr2+, Ba2+, Ca2+, Mn2+, Co2+, Ni2+, and Mg2+.", "In a further embodiment said solution II a mixture of any cation selected from the group consisting of Na+, K+, NH4+, Li+, Ca2+, and Mg2+.", "In a very preferred embodiment said mixture comprises or preferably consists of Na+ and K+.", "In a preferred embodiment said solution II comprises at least 20 mM, preferably at least 100 mM, more preferably 200 to 275 mM, and most preferably 250 mM of said cation or of said mixture of cations.", "In a very preferred embodiment said solution II comprises 250 mM of Na+ and K+, most preferably 250 mM of Na+.", "In still further preferred embodiment said solution II comprises 250 mM of sodium chloride or potassium chloride, most preferably 250 mM of sodium chloride.", "However, any sodium, potassium, ammonium, lithium, calcium or magnesium salt known in the art can be used for this purpose.", "In a further embodiment the concentration of said oligonucleotide in said solution II is 50 μM to 2 mM, preferably 100 to 300 μM most preferably 175 μM.", "In a further embodiment said process further comprises adjusting the temperature of solution II to temperature III, wherein said temperature III is 50 to 99° C., preferably 80 to 90° C., more preferably about 85° C., and most preferably 85° C. In a further embodiment said process comprises incubating said oligonucleotide in solution II at temperature III, wherein said incubating is performed until said oligonucleotide comprises a relative peak start time of 50 to 110%, preferably of 80 to 95%, more preferably of 80 to 90%, still more preferably of 83 to 90%, still more preferably of 85 to 90%, and most preferably of 88%.", "In a very preferred embodiment said oligonucleotide is G10 (SEQ ID NO:8) and said incubating is performed until said oligonucleotide comprises a relative peak start time of 50 to 110%, preferably of 80 to 95%, more preferably of 80 to 90%, still more preferably of 83 to 90%, still more preferably of 85 to 90%, and most preferably of 88%.", "The incubation time required to obtain oligonucleotide comprising the desired relative peak start time depends on the sequence and the purity of the oligonucleotide and ranges typically and preferably from about 5 min to about 30 min.", "In a preferred embodiment said oligonucleotide is G10 (SEQ ID NO:8) and said incubating of said oligonucleotide in said solution II at said temperature III is performed for 9 to 24 min.", "The aggregation process is terminated by cooling solution II below 50° C. In a preferred embodiment said process comprises adjusting the temperature of solution II to temperature IV, wherein said temperature IV is below 50° C., and wherein preferably said temperature IV is 0 to 25° C., more preferably 0 to 10° C., and most preferably 0 to 2° C. It has been found that the heating and/or cooling rates applied in the process of the invention have impact on yield and particle size distribution of the aggregated oligonucleotide obtained.", "In particular, it was found in the course of up-scaling of the process to higher batch volumes, that yield and particle size distribution can be further improved by using temperature ramps (i.e.", "heating or cooling rates) of at least 3.6° C./min.", "The artisan can achieve a defined temperature ramp by standardizing the process conditions with respect to the reaction volume, geometry and heat conductivity of the reaction vessel and the temperature difference chosen.", "In a preferred embodiment, said adjusting the temperature of solution I to temperature I, said adjusting the temperature of said solution I to temperature II, said adjusting the temperature of solution II to temperature III, and/or said adjusting the temperature of solution II to temperature IV are performed with a temperature ramp of least 3.6° C./min.", "In a further preferred embodiment, said adjusting the temperature of solution II to temperature III, is performed with a temperature ramp of least 3.6° C./min, wherein preferably said temperature ramp is about 7° C./min.", "In a further preferred embodiment, said adjusting the temperature of solution II to temperature IV is performed with a temperature ramp of least 3.6° C./min, wherein preferably said temperature ramp is about 7° C./min.", "In order to be capable of forming aggregates, said oligonucleotide comprises at least one, preferably two poly G stretches.", "In a preferred embodiment said oligonucleotide comprises at its 5′ end at least 3, preferably at least 4 guanosine entities and at its 3′ end at least 3, preferably at least 4 guanosine entities.", "In a further preferred embodiment said oligonucleotide comprises at its 5′ end at least 4 guanosine entities and at its 3′ end at least 4 guanosine entities.", "In a preferred embodiment said oligonucleotide comprises at its 5′ end at least 3 and at most 20, preferably at most 15 guanosine entities and at its 3′ end at least 3 and at most 20, preferably at most 15 guanosine entities.", "In a further preferred embodiment said oligonucleotide comprises at its 5′ end at least 3, preferably at least 4, and at most 11 guanosine entities and at its 3′ end at least 3, preferably at least 4 and at most 10 guanosine entities.", "In a further preferred embodiment said oligonucleotide is an unmethylated CpG containing oligonucleotide, preferably wherein said unmethylated CpG containing oligonucleotide comprises two poly G stretches, wherein preferably each of said poly G stretches consists of at least 4 guanosine entities, and wherein further preferably said unmethylated CpG containing oligonucleotide comprises a palindromic sequence, wherein said palindromic sequence is located between said poly G stretches.", "In a further preferred embodiment said oligonucleotide comprises at its 5′ end at least 3, preferably at least 4 guanosine entities and at its 3′ end at least 3, preferably at least 4 guanosine entities, wherein said oligonucleotide further comprises a palindromic sequence, wherein preferably said palindromic sequence is GACGATCGTC (SEQ ID NO:1).", "In a further preferred embodiment said oligonucleotide comprises a palindromic sequence, wherein preferably said palindromic sequence is GACGATCGTC (SEQ ID NO:1), and wherein said palindromic sequence is flanked at its 5′ end by at least 3, preferably at least 4, and at most 15 guanosine entities and wherein said palindromic sequence is flanked at its 3′ end by at least 3, preferably at least 4, and at most 15 guanosine entities.", "In a further preferred embodiment said oligonucleotide comprises 10 to 1000 nucleotides, preferably 10 to 200 nucleotides, more preferably 10 to 100 nucleotides, still more preferably 20 to 40 nucleotides, most preferably 30 nucleotides.", "In a very preferred embodiment said oligonucleotide comprises or preferably consists of a nucleic acid sequence selected from the group consisting of: (a) “G4-4” GGGGGACGAT CGTCGGGG (SEQ ID NO:2); (b) “G5-5” GGGGGGACGA TCGTCGGGGG (SEQ ID NO:3); (c)“G6-6” GGGGGGGACG ATCGTCGGGG GG (SEQ ID NO:4); (d) “G7-7” GGGGGGGGAC GATCGTCGGG GGGG (SEQ ID NO:5); (e)“G8-8” GGGGGGGGGA CGATCGTCGG GGGGGG (SEQ ID NO:6); (f) “G9-9” GGGGGGGGGG ACGATCGTCG GGGGGGGG (SEQ ID NO:7); (g) “G10” GGGGGGGGGG GACGATCGTC GGGGGGGGGG (SEQ ID NO:8); (h) “G11” GGGGGGGGGG GGACGATCGT CGGGGGGGGG GG (SEQ ID NO:9), wherein preferably said oligonucleotide entirely consists of phosphodiester bound nucleotides.", "In a still more preferred embodiment said oligonucleotide comprises or preferably consists of the nucleic acid sequence “G10” GGGGGGGGGGGACGATCGTCGGGGGGGGGG (SEQ ID NO:8), wherein preferably said oligonucleotide entirely consists of phosphodiester bound nucleotides.", "The invention further relates to a nucleotide composition comprising an oligonucleotide, wherein said nucleotide composition is obtainable by any one of the processes described above, implementing any one of the embodiments described above, alone or in any combination.", "In particular, the invention relates to a nucleotide composition comprising an oligonucleotide, wherein said nucleotide composition is obtainable by any one of the processes described above, wherein preferably said oligonucleotide comprises a relative peak start time of 50 to 110%, preferably of 80 to 95%, more preferably of 80 to 90%, still more preferably of 83 to 90%, still more preferably of 85 to 90%, and most preferably of 88%.", "In a preferred embodiment, said nucleotide composition comprises an oligonucleotide, wherein said oligonucleotide comprises or preferably consists of a nucleic acid sequence selected from the group consisting of: (a) “G4-4” GGGGGACGAT CGTCGGGG (SEQ ID NO:2); (b) “G5-5” GGGGGGACGA TCGTCGGGGG (SEQ ID NO:3); (c)“G6-6” GGGGGGGACG ATCGTCGGGG GG (SEQ ID NO:4); (d) “G7-7” GGGGGGGGAC GATCGTCGGG GGGG (SEQ ID NO:5); (e)“G8-8” GGGGGGGGGA CGATCGTCGG GGGGGG (SEQ ID NO:6); (f)“G9-9” GGGGGGGGGG ACGATCGTCG GGGGGGGG (SEQ ID NO:7); (g) “G10” GGGGGGGGGG GACGATCGTC GGGGGGGGGG (SEQ ID NO:8); (h) “G11” GGGGGGGGGG GGACGATCGT CGGGGGGGGG GG (SEQ ID NO:9), wherein preferably said oligonucleotide entirely consists of phosphodiester bound nucleotides.", "In a still more preferred embodiment said nucleotide composition comprises an oligonucleotide, wherein said oligonucleotide comprises or preferably consists of the nucleic acid sequence “G10” GGGGGGGGGGGACGATCGTCGGGGGGGGGG (SEQ ID NO:8), wherein preferably said oligonucleotide entirely consists of phosphodiester bound nucleotides.", "In very preferred embodiment said nucleotide composition comprises an oligonucleotide, wherein said oligonucleotide consists of the nucleic acid sequence “G10” GGGGGGGGGGGACGATCGTCGGGGGGGGGG (SEQ ID NO:8), wherein said oligonucleotide entirely consists of phosphodiester bound nucleotides, and wherein said oligonucleotide comprises a relative peak start time of 50 to 110%, preferably of 80 to 95%, more preferably of 80 to 90%, still more preferably of 83 to 90%, still more preferably of 85 to 90%, and most preferably of 88%.", "As mentioned before, the nucleotide compositions of the invention are useful in a process for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, because aggregated oligonucleotide as contained in the nucleotide compositions of the invention facilitates the self assembly of coat protein of RNA bacteriophages and, thus, the formation of virus-like particles of RNA bacteriophages, wherein said oligonucleotide is packages into said virus-like particles.", "The invention therefore further relates to a process for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, said process comprising the steps of: (a) providing coat protein of said RNA bacteriophage; (b) providing a nucleotide composition comprising an oligonucleotide, wherein said nucleotide composition is a nucleotide composition obtainable by any one of the processes of the invention; (c) generating a mixture, wherein said mixture comprises: (i) said coat protein; (ii) an agent capable of preventing the self-assembly of said coat protein; (iii) said oligonucleotide; (d) removing said agent from said mixture; and (e) allowing said coat protein to self assemble into a virus-like particle.", "Said process may comprise any one of the features and embodiments described herein in any combination.", "Oligonucleotide comprising a relative peak start time of 50 to 110% is most useful for the purpose of the invention, whereas oligonucleotide comprising a higher or lower relative peak start time may result in low yield.", "Thus, the invention further provides a process for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, said process comprising the steps of: (a) providing coat protein of said RNA bacteriophage; (b) providing an oligonucleotide, (i) wherein said oligonucleotide preferably comprises at least one poly G stretch; and (ii) wherein said oligonucleotide comprise a relative peak start time of 50 to 110%; (c) generating a mixture, wherein said mixture comprises: (i) said coat protein; (ii) an agent capable of preventing the self-assembly of said coat protein; (iii) said oligonucleotide; (d) removing said agent from said mixture; and (e) allowing said coat protein to self assemble into a virus-like particle.", "Said process may comprise any one of the features and embodiments described herein in any combination.", "The artisan is able to produce and to purify coat protein of RNA bacteriophages by purifying said coat protein from RNA bacteriophages by applying standard methods.", "However, in a preferred embodiment said coat protein is recombinantly produced, preferably by expression of said coat protein in E. coli.", "Methods for obtaining coat protein of RNA bacteriophages are disclosed in the Examples section.", "In a preferred embodiment said coat protein comprises, or alternatively essentially consists of, or alternatively consists of recombinant proteins, or fragments thereof, of a RNA bacteriophage, wherein preferably said RNA bacteriophage is selected from the group consisting of: (a) bacteriophage Qβ; (b) bacteriophage R17; (c) bacteriophage fr; (d) bacteriophage GA; (e) bacteriophage SP; (f) bacteriophage MS2; (g) bacteriophage M11; (h) bacteriophage MX1; (i) bacteriophage NL95; (j) bacteriophage f2; (k) bacteriophage PP7; and bacteriophage AP205.In a preferred embodiment said RNA bacteriophage is bacteriophage Qβ.", "Processes and methods for expressing and purifying virus-like particles of RNA bacteriophages, in particular of bacteriophage Qβ are disclosed in WO2006/125821A2 and WO2007/039552A1, which are incorporated herein by way of reference.", "Coat protein of RNA bacteriophage can be obtained by disassembly of virus-like particles, e.g.", "as described in the Examples herein.", "In a further preferred embodiment said RNA bacteriophage is bacteriophage AP205.Assembly-competent mutant forms of AP205 VLPs, including AP205 coat protein with the substitution of proline at amino acid 5 to threonine, may also be used in the practice of the invention.", "WO 2004/007538 describes, in particular in Example 1 and Example 2, how to obtain VLP comprising AP205 coat proteins, and hereby in particular their expression and purification.", "WO 2004/007538 is incorporated herein by way of reference.", "In a further preferred embodiment said RNA bacteriophage is bacteriophage fr.", "Fr coat protein in the form of recombinant VLP may be obtained as described by Pushko P et al.", "((1993) Prot Engin 6:883-891).", "In a further preferred embodiment said RNA bacteriophage is bacteriophage GA. GA VLP may be obtained by cloning GA coat protein cDNA isolated by reverse transcription from GA phage into pQb185, which is described for example in WO2004/007538.Disassembly of Fr and GA VLPs can be readily done by incubating the VLPs in 7 M urea, optionally supplemented with acetic acid at a concentration of 0.1 M. The nucleic acid is further purified from the coat protein by ion exchange chromatography, either at a pH where a significant amount of the coat protein flows through while the nucleic acid is retained, or at a pH where the coat protein is also adsorbed on the column and subsequently eluted with a salt gradient.", "In one preferred embodiment, said coat protein comprises or preferably consists of an amino acid sequence selected from the group consisting of: (a) SEQ ID NO:10 (Qβ CP); (b) a mixture of SEQ ID NO:10 and SEQ ID NO:11 (Qβ A1 protein); (c) SEQ ID NO:12 (R17 coat protein); (d) SEQ ID NO:13 (fr coat protein); (e) SEQ ID NO:14 (GA coat protein); (f) SEQ ID NO:15 (SP coat protein); (g) a mixture of SEQ ID NO:15 and SEQ ID NO:16; (h) SEQ ID NO:17 (MS2 coat protein); (i) SEQ ID NO:18 (M11 coat protein); (j) SEQ ID NO:19 (MX1 coat protein); (k) SEQ ID NO:20 (NL95 coat protein); (1) SEQ ID NO:21 (f2 coat protein); (m) SEQ ID NO:22 (PP7 coat protein); and (n) SEQ ID NO:23 (AP205 coat protein).", "In a further preferred embodiment, aid coat protein comprises or preferably consists of an amino acid sequence selected from the group consisting of: (a) SEQ ID NO:10; (b) a mixture of SEQ ID NO:11 and SEQ ID NO:11; (c) SEQ ID NO:13; (d) SEQ ID NO:14; (e) SEQ ID NO:23.In a further very preferred embodiment said coat protein aid coat protein comprises or preferably consists of an amino acid sequence selected from the group consisting of: (a) SEQ ID NO:10; and (b) a mixture of SEQ ID NO:10 and SEQ ID NO:11.Furthermore, mutant coat protein of bacteriophage Qβ wherein exposed lysine residues are replaced by arginines can be used for the present invention.", "Thus, in a further preferred embodiment said coat protein comprises, consists essentially of or alternatively consists of mutant Qβ coat proteins as disclosed WO02/056905 (cf.", "Example 18 therein).", "Further RNA bacteriophage coat proteins have also been shown to self-assemble upon expression in a bacterial host (Kastelein, R A. et al., Gene 23:245-254 (1983), Kozlovskaya, T M. et al., Dokl.", "Akad.", "Nauk SSSR 287:452-455 (1986), Adhin, M R. et al., Virology 170:238-242 (1989), Priano, C. et al., J. Mol.", "Biol.", "249:283-297 (1995)).", "In particular the biological and biochemical properties of GA (Ni, CZ., et al., Protein Sci.", "5:2485-2493 (1996), Tars, K et al., J. Mol.", "Biol.", "271:759-773(1997)) and of fr (Pushko P. et al., Prot.", "Eng.", "6:883-891 (1993), Liljas, L et al.", "J Mol.", "Biol.", "244:279-290, (1994)) have been disclosed.", "The crystal structure of several RNA bacteriophages has been determined (Golmohammadi, R. et al., Structure 4:543-554 (1996)).", "Typically and preferably, the processes disclosed herein for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle are carried out at room temperature.", "In a preferred embodiment said processes are performed at 15 to 30° C., preferably at 19 to 25° C., most preferably at 22° C. In a further preferred embodiment said generating of said mixture, said removing said agent from said mixture, and/or said allowing said coat protein to self assemble into a virus-like particle is performed at 15 to 30° C., preferably at 19 to 25° C., most preferably at 22° C. Said process comprises generating a mixture, wherein said mixture comprises: (i) said coat protein; (ii) an agent capable of preventing the self-assembly of said coat protein; (iii) said oligonucleotide.", "In a preferred embodiment the concentration of said coat protein in said mixture is 0.5 to 10 mg/ml, preferably 1 to 4 mg/ml, and most preferably 2.5 mg/ml, wherein preferably said concentration is determined in a Bradford assay.", "In a further preferred embodiment the concentration of said oligonucleotide in said mixture is 12.5 to 250 μM, more preferably 25 to 100 μM, and most preferably 62.5 μM.", "In order to obtain optimal yield of the packaging process, the molar ratio of said oligonucleotide and of said coat protein in said mixture is 0.5 to 1.2, preferably 0.6 to 0.8 and most preferably 0.7.The use of less oligonucleotide per coat protein will lead to low yield while the use of an excessive overshoot of oligonucleotide increases costs and may result in a product with low purity.", "In a very preferred embodiment the concentration of said coat protein in said mixture is 2.5 mg/ml, and the concentration of said oligonucleotide in said mixture is 62.5 μM.", "Coat proteins of viruses and in particular of RNA bacteriophages generally have a strong tendency to self assembly into a capsid structure, e.g.", "into a virus like particle.", "Though not in each case, this tendency is in many cases enhanced in the presence of nucleic acids such as RNA or DNA.", "In order to obtain optimal mixing of said coat protein and said oligonucleotide before the self assembly of said coat protein takes place, said mixture comprises an agent capable of preventing the self-assembly of said coat protein.", "Typically and preferably said agent comprises a denaturing compound.", "Numerous denaturing compounds are known in Biochemistry and include detergents, urea or guanidiniumhydrochloride.", "Preferred detergents are sodiumdodecylsulfate, Tween 20, TritonX 100 and the like.", "In a preferred embodiment said denaturing compound is urea or guanidiniumhydrochloride, wherein preferably the concentration of said denaturing compound, preferably of said urea, in said mixture is 0.25 to 7.2 M, preferably 1 M. In a very preferred embodiment said denaturing compound is urea, and the concentration of said urea in said mixture is 0.5 to 2 M, preferably 0.7 to 1.5 M, more preferably 0.8 to 1.2 M, and most preferably 1 M. In a further preferred embodiment the pH of said mixture is about neutral, preferably said pH is 6 to 8, more preferably 6.8 to 7.5, and most preferably said pH is 7.2.In a very preferred embodiment said mixture comprises a phosphate buffer, preferably a sodium phosphate buffer, wherein further preferably the final concentration of said phosphate buffer in said mixture is 2 to 100 mM, more preferably 10 to 50 mM and most preferably about 20 mM.", "In a further embodiment said mixture further comprises salt, wherein preferably said salt is a halogenide, preferably a chloride of an alkaline metal, more preferably said salt is potassium chloride or sodium chloride or a combination thereof, and most preferably said salt is sodium chloride.", "In a preferred embodiment the concentration of said salt or said combination of salts, preferably the concentration of said sodium chloride, in said mixture is 0 to 1 M, preferably 0 to 550 mM, more preferably 0 to 350 mM, still more preferably 50 to 350 mM, and most preferably 250 mM.", "The capsid and/or virus-like particles of certain RNA bacteriophages, in particular of bacteriophage Qβ, bacteriophage AP205, and bacteriophage fr, are stabilized by intermolecular disulfide bonds between the protein subunits forming said capsid or virus-like particle.", "The addition of a reducing agent to said mixture keeps said disulfide bridges in a reduced state and, thus, supports the prevention of the self assembly of said coat protein.", "In a preferred embodiment said agent therefore further comprises a reducing agent, wherein said reducing agent is preferably selected from DTT (dithioerythol), β-mecaptoetanol, TCEP and other reducing agents generally known in the art.", "In a preferred embodiment said reducing agent is DTT, wherein preferably the concentration of said DTT in said mixture is 1 to 25 mM, preferably 2.5 mM.", "In a very preferred embodiment said RNA bacteriophage is bacteriophage Qβ, bacteriophage AP205, or bacteriophage fr, and said agent further comprises a reducing agent, wherein preferably said reducing agent is DTT, and wherein further preferably the concentration of said DTT in said mixture is 1 to 25 mM, preferably 2.5 mM.", "In a further preferred embodiment said coat protein comprises cystein residues capable of forming intermolecular disulfide bonds in said virus-like particle, and said agent further comprises a reducing agent, wherein preferably said reducing agent is DTT, and wherein further preferably the concentration of said DTT in said mixture is 1 to 25 mM, preferably 2.5 mM.", "In a preferred embodiment said generating said mixture comprises adding (i) said coat protein; (ii) said agent capable of preventing the self-assembly of said coat protein; and (iii) said oligonucleotide to said mixture, wherein preferably said adding is performed in the given order, and wherein further preferably said mixture is mixed prior to said adding of said oligonucleotide.", "In a further preferred embodiment said process further comprises the step of incubating said mixture prior to said removing of said agent, wherein preferably said incubating is performed for about 50 to 70, preferably about 60 min.", "In a further preferred embodiment incubating of said mixture is performed at 15 to 30° C., more preferably at 19 to 25° C., and most preferably at 22° C. In a further preferred embodiment said incubating of said mixture comprises stirring said mixture, wherein preferably said stirring is performed at about 50 to 200 rpm, most preferably at about 100 rpm.", "In a very preferred embodiment said incubating of said mixture is performed for about 60 min, and said incubating of said mixture comprises stirring said mixture, wherein preferably said stirring is performed at about 100 rpm.", "In one embodiment said removing of said agent from said mixture is performed by a first buffer exchange with a first buffer, wherein preferably said first buffer exchange is performed by dialysis or by continuous flow filtration, preferably by continuous flow filtration.", "Said first buffer exchange is performed across a membrane comprising a molecular weight cut off which allows the retention of said coat protein and of the self assembled VLP.", "In a preferred embodiment said first buffer exchange is performed across a membrane, wherein said membrane comprises a molecular weight cut off of 1 to 50 kD, preferably of 5 to 30 kD, most preferably of 30 kD.", "In a very preferred embodiment said first buffer exchange is performed by continuous flow filtration across a membrane comprising a molecular weight cut off of 1 to 50 kD, preferably of 30 kD, wherein further preferably the volume of said first buffer is about 6 times the volume of said mixture.", "In a very preferred embodiment said membrane is Biomax-5 (PES) comprising 30 kD molecular weight cut off.", "In a very preferred embodiment said first buffer exchange is performed by continuous flow filtration across a membrane comprising a molecular weight cut off of 1 to 50 kD, preferably of 30 kD, wherein the permeate flow is adjusted to about 96 l/(m2*h).", "In a further preferred embodiment said first buffer comprises a salt, wherein preferably the salt composition of said first buffer is identical to the salt composition of said mixture.", "In a preferred embodiment said salt in said first buffer is a halogenide, preferably a chloride of an alkaline metal, more preferably said salt is potassium chloride or sodium chloride or a combination thereof, and most preferably said salt is sodium chloride.", "In a preferred embodiment the concentration of said salt or said combination of salts, preferably the concentration of said sodium chloride, in said first buffer is 0 to 1 M, preferably 0 to 550 mM, more preferably 0 to 350 mM, still more preferably 50 to 350 mM, and most preferably 250 mM.", "In a further preferred embodiment the pH of said first buffer is 6 to 8, more preferably 6.8 to 7.5, and most preferably said pH is 7.2.In a further preferred embodiment said first buffer comprises a phosphate buffer, preferably a sodium phosphate buffer, wherein further preferably the final concentration of said phosphate buffer in said first buffer is 2 to 100 mM, more preferably 10 to 50 mM and most preferably about 20 mM.", "In order to stabilize said virus-like particle formed in the self assembly reaction, said virus-like particle is preferably contacted with an oxidizing agent capable of forming intermolecular disulfide bonds in said virus-like particle.", "Thus, in a preferred embodiment said process further comprises the step of contacting said virus-like particle with an oxidizing agent, wherein preferably said oxidizing agent is selected from the group consisting of (a) hydrogen peroxide, wherein preferably the concentration of said hydrogen peroxide is 0.25-50 mM, preferably 2 mM; (b) oxygen; (c) gluthathion; (d) ascorbate; (e) Cu2+; and (f) Fe3+.", "In a very preferred embodiment said RNA bacteriophage is bacteriophage Qβ, bacteriophage AP205, or bacteriophage fr, and said process further comprises the step of contacting said virus-like particle with an oxidizing agent, wherein preferably said oxidizing agent is selected from the group consisting of (a) hydrogen peroxide, wherein preferably the concentration of said hydrogen peroxide is 0.25-50 mM, preferably 2 mM; (b) oxygen; (c) gluthathion; (d) Cu2+; and (e) Fe3+, and wherein most preferably said oxidizing agent is hydrogen peroxide, wherein further preferably the concentration of said hydrogen peroxide is 0.25-50 mM, preferably 2 mM.", "In a preferred embodiment said coat protein comprises cystein residues capable of forming intermolecular disulfide bonds in said virus-like particle, wherein preferably said coat protein is coat protein of bacteriophage Qβ, bacteriophage AP205 or bacteriophage fr, and said process further comprises the step of contacting said virus-like particle with an oxidizing agent, wherein preferably said oxidizing agent is selected from the group consisting of (a) hydrogen peroxide, wherein preferably the concentration of said hydrogen peroxide is 0.25-50 mM, preferably 2 mM; (b) oxygen; (c) gluthathion; (d) Cu2+; and (e) Fe2+, and wherein most preferably said oxidizing agent is hydrogen peroxide, wherein further preferably the concentration of said hydrogen peroxide is 0.25-50 mM, preferably 2 mM.", "In a further preferred embodiment said process further comprises the step of purifying said virus-like particle, wherein preferably said purifying comprises a second buffer exchange with a second buffer, wherein further preferably said second buffer is a pharmaceutically acceptable buffer.", "In a preferred embodiment said second buffer exchange is performed with a second buffer, wherein preferably said second buffer exchange is performed by dialysis or by continuous flow filtration, preferably by continuous flow filtration.", "Said second buffer exchange is performed across a membrane comprising a molecular weight cut off which allows the retention of said virus-like particle, and which preferably allows the permeation of said coat protein and/or of said oligonucleotide.", "Thus, in a preferred embodiment said second buffer exchange is performed across a membrane comprising a molecular weight cut off of 100 to 1000 kD, preferably of 300 kD, wherein preferably said second buffer exchange is performed by continuous flow filtration.", "In a very preferred embodiment said membrane is PLCMK-300 comprising 300 kD molecular weight cut off.", "In a further very preferred embodiment said second buffer exchange is performed by continuous flow filtration across a membrane comprising a molecular weight cut off of 100 to 1000 kD, preferably of 300 kD, wherein preferably about 10 times the volume of said mixture is exchanged, and wherein further preferably the permeate flow is adjusted to about 100 l/(m2*h).", "In a further embodiment said process comprises concentrating said virus-like particle, wherein preferably said concentrating is performed to a final concentration of said virus like particle in said composition of 1 to 5 mg protein/ml, preferably of about 2.5 mg protein/ml, wherein preferably said concentration is determined by Bradford protein assay, and wherein further preferably said virus-like particle is dissolved in said second buffer.", "In a very preferred embodiment said concentrating is performed across a membrane capable of retaining said virus-like particle, wherein preferably the molecular weight cut off of said membrane is 100 to 1000 kD, preferably about 300 kD, and wherein further preferably said concentrating is performed with a permeate flow across said membrane of less than 100 l/(h*m2), preferably about 30 l/(h*m2).", "Low flow rates during the concentration step prevent the precipitation of the product.", "In a further preferred embodiment said process further comprises the step of sterile filtrating said virus-like particle, wherein preferably said virus-like particle is contained in said second buffer, wherein further preferably said sterile filtrating is performed across a membrane filter comprising 0.1 to 0.45 μm, preferably about 0.22 μm.", "In a further preferred embodiment the processes according to the invention for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, comprise a protein yield, wherein said protein yield is at least 50%, preferably at least 60%, more preferably at least 70%, still more preferably at least 75%, and most preferably at least 80%.", "In a further preferred embodiment the processes according to the invention for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, comprise an oligonucleotide yield, wherein said oligonucleotide yield is at least 50%, preferably at least 60%, more preferably at least 70%, still more preferably at least 75%, and most preferably at least 80%.", "In a further preferred embodiment said composition comprising said virus-like particle comprises a purity of at least 80%, preferably at least 90%, more preferably at least 95%, still more preferably at least 98%, and most preferably at least 99%.", "In a further preferred embodiment the processes according to the invention for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, comprise an oligonucleotide yield, wherein said oligonucleotide yield is at least 50%, preferably at least 60%, more preferably at least 70%, still more preferably at least 75%, and most preferably at least 80%.", "In a further preferred embodiment the processes according to the invention for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, comprise a protein yield and an oligonucleotide yield, wherein said protein yield is at least 50%, preferably at least 60%, more preferably at least 70%, still more preferably at least 75%, and most preferably at least 80%.", "In a further preferred embodiment said composition comprising said virus-like particle comprises 15 to 30 μg, preferably 20 to 25 μg, and most preferably about 20 μg of said oligonucleotide per 100 μg coat protein, wherein preferably said virus-like particle is a virus like particle of bacteriophage Qβ, and wherein further preferably said oligonucleotide is G10 (SEQ ID NO:8), wherein still further preferably said composition comprising said virus-like particle comprises a purity of at least 98%, preferably of at least 99%, wherein still further preferably the quantification of said coat protein is performed by Bradford protein assay, and wherein still further preferably the quantification of said oligonucleotide is performed essentially, preferably exactly as disclosed in Example 9.The invention further relates to the use of a nucleotide composition obtainable by any one of the processes of the invention, in a process for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, wherein preferably said process comprises the steps of (a) providing coat protein of said RNA bacteriophage; (b) providing said nucleotide composition; (c) generating a mixture, wherein said mixture comprises: (i) said coat protein; (ii) an agent capable of preventing the self-assembly of said coat protein; (iii) said oligonucleotide; (d) removing said agent from said mixture; and (e) allowing said coat protein to self assemble into a virus-like particle; wherein preferably said oligonucleotide contained in said nucleotide composition comprises a relative peak start time of 50 to 110%, wherein further preferably said RNA bacteriophage is Qβ, and wherein still further preferably said oligonucleotide is G10 (SEQ ID NO:8).", "The invention further relates to the use of an oligonucleotide comprising a relative peak start time of 50 to 110% in a process for producing a composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, wherein preferably said process comprises the steps of (a) providing coat protein of said RNA bacteriophage; (b) providing said oligonucleotide, (c) generating a mixture, wherein said mixture comprises: (i) said coat protein; (ii) an agent capable of preventing the self-assembly of said coat protein; (iii) said oligonucleotide; (d) removing said agent from said mixture; and (e) allowing said coat protein to self assemble into a virus-like particle; wherein preferably said RNA bacteriophage is Qβ, and wherein further preferably said oligonucleotide is G10 (SEQ ID NO:8).", "The invention further relates to a composition obtainable by any one of the processes of the invention, said composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, wherein preferably said RNA bacteriophage is Qβ, and wherein further preferably said oligonucleotide is G10 (SEQ ID NO: 8), and wherein still further preferably the purity of said composition is at least 80%, preferably at least 90%, more preferably at least 95%, still more preferably at least 98% and most preferably at least 99%, and wherein still further preferably said composition comprising said virus-like particle comprises 15 to 30 μg, preferably 20 to 25 μg, and most preferably about 20 μg of said oligonucleotide per 100 μg coat protein.", "The invention further relates to a composition obtainable by any one of the processes of the invention, said composition comprising (i) a virus-like particle, wherein said virus-like particle is a virus-like particle of an RNA bacteriophage, and (ii) an oligonucleotide, wherein said oligonucleotide is packaged into said virus-like particle, wherein preferably said RNA bacteriophage is Qβ, and wherein further preferably said oligonucleotide is G10 (SEQ ID NO: 8), wherein still further preferably the purity of said composition is at least 80%, preferably at least 90%, more preferably at least 95%, still more preferably at least 98% and most preferably at least 99%, wherein said oligonucleotide in not accessible to DNAse hydrolysis.", "EXAMPLES Example 1 Disaggregation and Aggregation of Oligonucleotide G10 (SEQ ID NO:8) Quantification of G10: G10 was quantified by UV absorption at 260 nm corrected by the absorption at 340 nm, wherein 1 A260-340 corresponds to a concentration of 27.8 μg/ml at 1 cm path length.", "Disaggregation (10.0 ml Scale, 260 μM G10, 25 mM NaOH, 50° C., 70 min): 45.91 mg G10 were weighed into a 15 ml tube.", "The powder was dissolved in 11.0 ml purified water (c=325.3 μM; determined by spectrometry).", "8.0 ml of the oligonucleotide solution were mixed with 250 μl 1 M NaOH and 1.75 ml purified water in a 15 ml tube (260 μM G10, 25 mM NaOH).", "The mixture was disaggregated for 70 minutes at 50° C. in a water bath.", "After cooling the solution on ice, the pH was adjusted with 0.5 M HCl to pH 5.31; 540 μl 0.5 M HCl and 5 μl 1 M NaOH were added.", "Aggregation (10.0 ml Scale, 175 μM G10, 250 mM Na+, 85° C., 9-24 min): 7.1 ml disaggregated G10 solution, 2.13 ml purified water and 770 μl 3 M NaCl were mixed in a 15 ml tube (175 μM oligo, 250 mM Na+).", "The mixture was incubated for 9 minutes at 85° C. in a water bath.", "The solution was cooled down in an ice/water bath and stored on ice until use.", "Aggregated oligonucleotide solutions should be used within 3 hours after preparation.", "Example 2 Disaggregation and Aggregation of Oligonucleotides G4-4 Disaggregation: A solution of 260 μM oligonucleotide G4-4 (SEQ ID NO:2) and 25 mM NaOH in purified water was prepared.", "The solution was heated to 50° C. for 70 min and was then cooled down on ice, the pH of the solution was adjusted to a pH between 5 and 8 using 0.5 M HCl.", "Aggregation: The solution comprising the disaggregated G4-4 was diluted with purified water and 3 M NaCl to a final concentration of 230 μM G4-4 and 250 mM Na+.", "The mixture is was heated to 80° C. using a heating ramp of 6.8° C./min for several minutes (2 to 70 min).", "After the incubation the mixture was cooled down to 0-2° C. with a temperature ramp of 6.8° C./min.", "Analysis of the product by size exclusion HPLC (see Example 4) revealed that aggregated oligonucleotide was obtained.", "(relative peak start time: 88%).", "Example 3 Disaggregation and Aggregation of Oligonucleotides Disaggregation: A solution of 260 μM oligonucleotide G5-5 (SEQ ID NO:3), G6-6 (SEQ ID NO:4), G7-7 (SEQ ID NO:5), G8-8 (SEQ ID NO:6), G9-9 (SEQ ID NO:7) and G11 (SEQ ID NO:9), respectively, and 25 mM NaOH in purified water is prepared.", "The solution is heated to 50° C. for 70 min and is then cooled down on ice, the pH of the solution is adjusted to a pH between 5 and 8 using 0.5 M HCl.", "Aggregation: The solution comprising the disaggregated oligonucleotide is diluted with purified water and 3 M NaCl to a final concentration of 230 μM oligonucleotide and 250 mM Na+.", "The mixture is was heated to 80° C. using a heating ramp of 6.8° C./min for several minutes (2 to 70 min).", "After the incubation the mixture was cooled down to 0-2° C. with a temperature ramp of 6.8° C./min.", "The product of the aggregation process is analyzed by size exclusion HPLC (see Example 4).", "Example 4 Analysis of the Aggregation State of Oligonucleotide G10 by Size Exclusion HPLC The aggregation state of G10 was analyzed by analytical size exclusion HPLC using the following conditions: Column: TSKgel 5000 PWXL 7.8 mm*30.0 cm (Lot: 5PWX06GNMH3304, Art: 08023, Tosoh Bioscience) Eluent: PBS (150 mM NaCl in 20 mM sodium phosphate buffer, pH 7.2) Injection volume: 40.0 μl (preferably comprising a concentration of about 20 μM to about 500 μM) Flow rate: 0.8 ml/min Gradient: Isocratic Run time: 20 min Wavelength: 215, 260 and 280 nm, data evaluation at 260 nm Column oven temp.", ": 25° C. Autosampler temp.", ": 8° C. Capsid of bacteriophage Qβ was used as standard.", "The peak start time X % of G10 relative to Qβ capsid (relative peak start time Qβ) was calculated as follows: X %=peak start time [min] of the oligonucleotide divided by the retention time of Qβ capsid standard [min]×100%, wherein the peak start time of the oligonucleotide was determined as the time when the elution of the oligonucleotide became detectable, and wherein the retention time of the Qβ capsid standard was determined as the time of the occurrence of the maximum peak of the standard.", "An Example of an elution profile of oligonucleotide G10 and capsid of bacteriophage Qβ as standard is depicted in FIG.", "1.Based on the chromatograms depicted in FIG.", "1 a relative peak start time of 88% calculated for the aggregated oligonucleotide.", "Example 5 Comparison of the Relative Peak Start Times of Untreated, Disaggregated and Aggregated Oligonucleotide G10 The relative peak start time of disaggregated and aggregated G10 prepared essentially as described in Example 1 was determined and compared to the relative peak start time of untreated G10 as obtained from a commercial supplier.", "Disaggregated G10 showed a relative peak start time of 138% (136.9-140.3%; n=5).", "G10 preparations which have not undergone the disaggregation/aggregation treatment described in Example 1 show a relative peak start time in the same range as disaggregated G10.After disaggregation and aggregation, peak start time of G10 was found to be 88%.", "Example 6 The Impact of the Disaggregation Step Untreated oligonucleotide G10 and oligonucleotide G10 disaggregated as described in Example 1 was subjected to aggregation essentially as described in Example 1, wherein the following aggregation conditions were chosen: 175 μM G10, 250 mM Na+ (by addition of 3 M NaCl), incubation at 85° ° C. for 16 minutes, then cooling on ice.", "Both preparations were analyzed by size exclusion HPLC (see Example 4) using Qβ capsid and untreated G10 as standard.", "The resulting HPLC chromatograms are depicted in FIG.", "2.Untreated G10 contained aggregated G10 (see FIGS.", "2A and 2 B, box 1).", "Aggregated G10 which was not disaggregated prior to aggregation showed an equivalent or higher apparent molecular weight than Qβ capsid (FIG.", "2A, box 2).", "The relative peak start time was ca.", "75%.", "Aggregated G10 which was disaggregated prior to aggregation exhibited a lower apparent molecular weight than Qβ capsid (FIG.", "2B, box 2).", "The relative peak start time was ca.", "88%.", "Example 7 Analysis of the Aggregation State of Oligonucleotide G10 by Circular Dichroism CD spectra of untreated, disaggregated and aggregated G10 (prepared essentially as described in Example 1) as well as of Qβ capsid packaged with G10 (QbG10 obtained as described in Example 10) were recorded between 200 nm and 300 nm on a JASCO J-715 spectrophotometer.", "(FIG.", "3).", "The spectrum of aggregated G10 is characterized by a strong positive band (high elliptic) with a maximum at 262 nm and a trough at 240 nm.", "These signals are reported to correspond to the typical spectrum of DNA tetraplexes with a parallel orientation of strands (Lu et al., Biochemistry 31, p. 2455, 1992).", "Importantly, the shape of the CD spectrum in the region of 250 nm-300 nm does not change in spectra of VLPs reassembled in the presence of aggregated G10.Thus, G10 does not seem to undergo a conformational change upon packaging.", "The slight increase of the amplitude at 262 nm possibly reflects the selective packing of aggregated G10 into Qβ capsids resulting in a higher proportion of tetraplexes after packaging compared to aggregated G10 which still contains a fraction of non-aggregated molecules.", "In contrast, the spectrum of untreated G10 is characterized by low ellipticities without defined maxima indicating a lack of defined secondary and tertiary structure elements.", "Low CD signals are also observed for disaggregated G10 even though the occurrence of a maximum at 295 nm and a minimum at 262 nm might reflect the presence of some antiparallel tetraplex conformers (P. Balagurumoorthy et al., Nucleic Acids Research 20, p. 4061, 1992).", "Example 8 Packaging of Qβ VLPs with G10 by Disassembly/Reassembly Disassembly of Qβ VLPs: 45 mg Q□ VLP (2.5 mg/ml, as determined by Bradford analysis) in PBS (20 mM Phosphate, 150 mM NaCl, pH 7.5), was reduced with 10 mM DTT for 15 min at RT under stirring conditions.", "Then, magnesium chloride was added to 0.7 M final concentration and the incubation was continued for 15 min at RT under stirring conditions, leading to precipitation of the encapsulated host cell RNA and concomitant disintegration of the VLPs.", "The solution was centrifuged 10 min at 4000 rpm at 4° C. (Eppendorf 5810 R, in fixed angle rotor A-4-62 used in all following steps) in order to remove the precipitated RNA from the solution.", "The supernatant, containing the released, dimeric Q□ coat protein, was used for the chromatographic purification steps.", "Purification of Oβ Coat Protein by Cation Exchange Chromatography and Size Exclusion Chromatography: The supernatant of the disassembly reaction, containing dimeric coat protein, host cell proteins and residual host cell RNA, was loaded onto a SP-Sepharose FF column (xk16/20, 6 ml, Amersham Bioscience).", "The column was equilibrated with 20 mM sodium phosphate buffer pH 7 and the sample was diluted 1:15 in water to adjust a conductivity below 10 mS/cm in order to achieve proper binding of the coat protein to the column.", "The elution of the bound coat protein was accomplished by a step gradient to 20 mM sodium phosphate/500 mM sodium chloride and the protein was collected in a fraction volume of approx.", "25 ml.", "The chromatography was carried out at RT with a flow rate of 5 ml/min during all steps and the absorbance was monitored at 260 nm and 280° nm.", "In a second step, the isolated Qβ coat protein (the eluted fraction from the cation exchange column) was loaded onto a Sephacryl S-100 HR column (xk26/60, 320 ml, Amersham Bioscience) equilibrated with 20 mM sodium phosphate/250 mM sodium chloride; pH 7.2.The chromatography was carried out at RT with a flow rate of 2.5 ml/min and the absorbance was monitored at 260 nm and 280 nm.", "Fractions of 5 ml were collected.", "Characterization of Purified Qβ Coat Protein by Analytical Size Exclusion Chromatography: A sample of purified Qβ coat protein was analyzed by analytical size exclusion chromatography (FIG.", "1C) and compared to i) intact Qβ VLP (FIG.", "4A), which had been purified from E. coli lysate and which was used as source material for the purification procedure, and ii) to the supernatant of the disassembly reaction (FIG.", "4B).", "Efficient separation of RNA molecules from the coat protein is indicated by the absence of any RNA-like peak (typical ratio of A280/A260=0.5) in FIG.", "4C and the presence of a unique protein-like peak (typical ratio of A280/A260=1.7).", "Assembly of QβG10 by Diafiltration: Purified coat protein (in 20 mM sodium phosphate pH 7.2, 250 mM NaCl) was mixed with water and stock solutions of urea, NaCl, DTT and aggregated G10 oligonucleotide (prepared essentially as described in Example 1).", "The volume of the mixture was 50 ml and the final concentrations of the components were 1 mg/ml coat protein, 1.0 M urea, 250 mM NaCl, 2.5 mM DTT and 0.24 mg/ml G10.The solution was then diafiltrated at room temperature against 300 ml of 20 mM sodium phosphate 250 mM NaCl pH 7.2, using a 30 kDa cut off cartridge (Pellicon XL, Millipore) and a cross flow rate of 10 ml/min and a permeate flow rate of 2.5 ml/min.", "H2O2 was added to 7 mM final concentration and the solution incubated for 1 h at RT in order to induce the formation of disulfide bonds.", "The solution was then diafiltrated against 500 ml of 20 mM sodium phosphate 150 mM NaCl pH 7.2, using a 300 kDa cut off cartridge (Pellicon XL, Millipore) and a cross flow rate of 10 ml/min and a permeate flow rate of 2.5 ml/min, in order to remove excess of H2O2 and non-packaged G10 oligonucleotides from the assembled QβG10 product.", "Example 9 Analysis of QβG10 Packaging Product and Determination of Yield of the Packaging Process Characterization of Packaged QβG10 VLP by Analytical Size Exclusion Chromatography: A sample of packaged QβG10 VLP was analyzed by analytical size exclusion chromatography (FIG.", "5) and compared to intact Qβ VLP, which had been purified from E. coli lysate.", "Said analytical size exclusion chromatography was performed using the following parameters: Column: Bio-Sil SEC 250, 7.8×300 mm, Cat.", "No.", "125-0062 Eluent: 50 mM Sodiumphospate pH 6.5, 150 mM NaCl Gradient: Isocratic Column temperature: 25° C. Autosampler temperature: 8° C. Flow rate: 1.0 ml/min Sample concentration: 1.0 mg/ml protein Injection volume: 40 μl Evaluation wavelength: 280 nm Bandwith: 4 nm Run time: 20 min Sample preparation: The sample was diluted to 1.0 mg/ml using eluent, the sample was vortexed shortly and centrifuged at 16′000 g for 10 minutes at 4° C. The presence of correctly assembled VLP in the product was confirmed by a peak migrating at identical retention time as the peak representing native Qβ VLP.", "The observed peak for QβG10 VLP (FIG.", "5D) is dominated by the nucleic acid content of the VLP, because the absorption coefficient nucleic acids at 260 nm is more than 100-fold higher than the absorption coefficient of the coat protein.", "The ratio A260/A280 of purified QβG10 VLP was found to be 1.70 (1.65-1.76; n=5), which is characteristic for G10 (A260/A280=1.74), wherein the A260/A280 ratio of Qβ VLP was found to be 1.87 (1.85-1.90; n=10) which is characteristic for RNA.", "Characterization of Packaged QβG10 VLP by SDS-PAGE Analysis: A sample of packaged Qβ G10 was analyzed by non-reducing SDS-PAGE (FIG.", "6) and compared to intact Qβ VLP, which had been purified from E. coli lysate.", "The presence of correctly assembled VLP in the product was confirmed by the formation of bands of disulfide-linked pentameric and hexameric forms of the coat protein, similar to the intact Qβ VLPs, indicating the correct structural arrangement of the coat protein units in the in vitro assembled QβG10 VLP.", "Quantification of Packaged Oligonucleotide G10: Samples of QβG10 VLP (0.25 mg/ml in PBS) were treated by 0.1 mM TCEP (Tris(2-chloroethyl)phosphate) (15 min at RT) in order to reduce the disulfide bonds.", "NaCl was added to the reduced samples (1 M final concentration) and the mixtures were incubated for 15 min at 60° C. in order to precipitate the protein component.", "After centrifugation, the resulting supernatants were incubated for 5 min at 95° C., cooled on ice for 1 min and then the A260 value was measured.", "The concentration of oligonucleotide G10 in the supernatants was calculated according to the formula: c(G10)(mg/ml)=A260×1.12×9600/344580, where: 1.12=correction factor for the salt content in the sample 9600=molecular mass of oligonucleotide G10 344580=specific molar absorption coefficient of oligonucleotide G10.Typically, the amount of packaged oligonucleotide G10 was 0.2 mg per mg of Qβ coat protein.", "G10 Content of QβG10 VLP and Yield Calculation for the Packaging Reaction: Aggregated G10 was packaged into Qβ VLP by assembly/reassembly of the VLP as described in Example 8.953 mg G10 oligonucleotide were introduced for reassembly with 4000 mg purified Qβ dimer.", "The reaction yielded QβG10 comprising 20 μg G10 oligonucleotide per 100 μg protein (protein content determined by Bradford analysis or HPLC).", "The G10 yield of the packaging reaction was 63% at a protein yield of 75%.", "Example 10 Assembly of QβG-10 by diafiltration and Determination of Yield Purified Qβ coat protein was obtained essentially as described in Example 8.Coat protein in 20 mM sodium phosphate pH 7.2, 250 mM NaCl was mixed with water and stock solutions of urea, NaCl, DTT and aggregated G10 oligonucleotide (prepared essentially as described in Example 1; relative peak start time of disaggregated G10 was 135%, relative peak start time of aggregated G10 was 88%).", "The volume of the mixture was 1.6 L and the final concentrations of the components were 2.5 mg/ml coat protein, 1.0 M urea, 250 mM NaCl, 2.5 mM DTT and 0.6 mg/ml G10.The solution was then diafiltrated at room temperature against 9.6 L of 20 mM sodium phosphate 250 mM NaCl pH 7.2, using a 30 kDa cut off cartridge (Pellicon Mini2, 0.1 m2 filter area, Millipore) and a cross flow rate of 384 L/(h*m2) and a permeate flow rate of 96 L/(h*m2).", "H2O2 was added to 2 mM final concentration and the solution incubated for 1 h at RT in order to induce the formation of disulfide bonds.", "The solution was then diafiltrated against 16 L of 20 mM sodium phosphate 150 mM NaCl pH 7.2, using a 300 kDa cut off cartridge (Pellicon Mini 2, 0.1 m2 filter area, Millipore) and a cross flow rate of 300 l/(h*m2) and a permeate flow rate of 100 l/(h*m2), in order to remove excess of H2O2 and non-packaged G10 oligonucleotides from the assembled QβG10 product.", "The product was concentrated to 2.5 mg/ml by tangential flow filtration and filtered through a 0.22 μm filter.", "The major process steps are summarized in Table 1.TABLE 1 Summary of the process steps for assembly and purification of QβG10.Output of the Process Process Step Parameters Step Disaggregation of G10 G10 concentration: 260 μM relative peak start NaOH concentration: 25 mM time of G10: 138% Temperature: 50° C. Heating time: 70 minutes Scale: 1.1 g G10, V = 440 ml (in 10 ml Aliquots) Neutralization of the Used Acid: 0.5M H3PO4 pH 7.2 disaggregated G10 solution Reaggregation of the G10 G10 concentration: 175 μM relative peak start solution Na+ concentration: 250 mM time of G10: 88% Temperature: 85° C. Heating time: 10 minutes Scale: 1.1 g G10, V = 654 ml (in 10 ml Aliquots) Thawing of the starting Temperature: 22° C. Qbeta dimer solution material Preparation of the Dimer concentration: 2.5 mg/ml Solution for reassembly mixture.", "Urea concentration: 1M diafiltration 1 DTT concentration: 2.5 mM G10 concentration: 62.5 μM Mixing time: 60 ± 10 minutes Temperature: 22 ± 3° C. Scale: 4 g Qβ Dimer, V = 1.61 Continuous diafiltration 1 Membrane: 30 kDa MWCO The Qbeta dimer forms Area: 0.1 m2 VLPs around the G10 Diafiltration volumes: 6 (9.6 L permate collected) core material due to Buffer: NaP250 pH 7.2 removal of urea and DTT.", "Target duration: 60 minutes Temperature: 22° C. Flux: 96 l/(h*m2) V = 1.61 Oxidation with hydrogen H2O2 concentration: 2 mM Formation of disulfide peroxide Temperature: 22° C. bridges and therefore Reaction time: 60 ± 10 minutes stabilization of the VLP V = 1.61 Continuous Diafiltration 2 Membrane: 300 kDa MWCO Removal of residual Area: 0.1 m2 hydrogen peroxide and Diafiltration volumes: 10 (16 L) residual, unpackaged Buffer: pharmaceutically G10.acceptable buffer Temperature: 22 ± 3° C. Flux: 100 l/(h*m2) V = 1.61 Concentration of QbG10 Membrane: 300 kDa MWCO Concentration = 2.5 mg/ml Area: 0.1 m2 Temperature: 22 ± 3° C. Permeate Flow: <100 l/(h*m2) V = 1.21 Filtration of QbG10 0.22 μm PES membrane filter Bioburden reduction The purity of the product was analyzed by size exclusion chromatography was found to be 99.28%, i.e.", "the QbG10 peak amounted to 99.28% of the entire peak area in a chromatography run as described in Example 4.Protein yield and oligonucleotide yield were determined as described in Example 8.The protein yield across the entire process was 75%.", "The oligonucleotide yield across the entire process was 75%.", "Example 11 Impact of the Aggregation State of G10 on the Assembly Process When G10 with a relative peak start time of 139% was used in the assembly process as described in Example 8, only negligible amounts of GbG10 were formed and no VLP product could be isolated.", "Example 12 Packaging of AP205 and GA355 VLPs with G10 by Disassembly/Reassembly Disassembly: 50-100 mg of AP205 or GA355 VLPs (as determined by Bradford analysis) in buffer A (5 mM NaPO4 pH 6.8, 100 mM NaCl, 2 mM MgCl2) were incubated at 30° C. for 16 hours with RNAse A (Sigma) and Benzonase (Novagen) at 1 mg/ml and 5 U/ml, respectively.", "In the case of AP205 VLP deoxidation of the internal disulfide bridges was performed preceding the addition of RNAse A and Benzonase by addition of 20 mM DTT followed by a 30 min incubation at 37° C. After addition of 1 M NaCl precipitation of the viral coat proteins was induced by 15 min incubation at 70° C. Precipitated coat proteins were sedimented by centrifugation for 10 min, 27,000 g at 4° C. The supernatant containing RNAse A, Benzonase and degraded nucleic acids was discarded.", "Pellets were resuspended in buffer B (20 mM NaPO4 pH 7.2, 6 M urea) and incubated for 10 min at room temperature.", "Purification of Coat Proteins by Cation Exchange Chromatography: The solutions were clarified by centrifugation for 10 min, 27,000 g at 4° C. A negligible pellet was discarded.", "And the supernatant containing the disassembled coat proteins were applied on a SP Sepharose™ FF column (16/20, Amersham Biosciences) equilibrated with buffer B (20 mM NaPO4 pH 7.2, 6 M urea).", "The flow through was discarded.", "After an extensive wash with buffer B (15 CV) the column was adjusted with a linear gradient from buffer B to buffer C (20 mM NaPO4 pH 7.2, 1 M urea) with a gradient length of 37.5 CV.", "During the loading, wash and elution the absorbance at 254 nm and 280 nm was monitored.", "Coat proteins were eluted as one fraction with buffer D (20 mM NaPO4 pH 6.5, 1 M urea, 300 mM NaCl) and analyzed by LDS-PAGE followed by Coomassie staining.", "Eluted protein fractions were stored at 4° C. as “disassembled coat protein”.", "Protein concentrations were determined by Bradford analysis.", "Reassembly: Purified AP205 or GA355 coat protein was used in a five fold excess (w/w) to G10 oligonucleotide.", "The coat proteins were mixed with the G10 oligonucleotide in a reassembly buffer containing 1 M urea and 2.5 mM DTT and incubated for one hour at room temperature.", "After incubation the reassembly mix was dialyzed for 24 hours against 5 liter PBS.", "The resulting suspension was centrifuged for 10 min, 27,000 g at 4° C. A negligible sediment was discarded.", "The supernatant contained the reassembled and packaged VLPs.", "Protein concentration was determined by Bradford analysis and the reassembled and packaged VLPs were concentrated with centrifugal filter devices (Amicon Ultra 15, 10K MWCO).", "Purification of Reassembled and Packaged VLPs: Up to 25 mg total protein was loaded onto a Sepharose™ CL-4B (26/60, Amersham Biosciences) equilibrated with PBS.", "Size exclusion chromatography was performed with equilibration buffer at room temperature with a flow rate of 1.25 ml/min.", "During the elution absorbance at 254 nm and 260 nm was monitored.", "Two peaks were isolated.", "A major high molecular weight peak preceded a small peak of lower apparent molecular weight.", "The major peak revealed a apparent molecular weight consistent to purified VLPs as shown by SE-HPLC.", "Analysis of AP205 or GA355 VLPs packaged with G10 oligonucleotide is performed essentially as shown in Example 16 of WO03/024481 (p. 131 ff).", "Example 13 Packaging of FR VLPs with G10 by Disassembly/Reassembly Disassembly: 50-100 mg of FR VLPs (as determined by Bradford analysis) in buffer A (5 mM NaPO4 pH 6.8, 100 mM NaCl, 2 mM MgCl2) are incubated at 30° C. for 16 hours with RNAse A (Sigma) and Benzonase (Novagen) at 1 mg/ml and 5 U/ml, respectively.", "After addition of 1 M NaCl precipitation of the FR coat proteins is induced by a 15 min incubation at 70° C. Precipitated coat proteins are sedimented by centrifugation for 10 min, 27,000 g at 4° C. The supernatant containing RNAse A. Benzonase and degraded nucleic acids are discarded.", "The pellet is resuspended in buffer B (20 mM NaPO4 pH 7.2, 6 M urea) and incubated for 10 min at room temperature.", "Purification of FR coat proteins by cation exchange chromatography: The solution is clarified by centrifugation for 10 min, 27,000 g at 4° C. A negligible pellet is discarded and the supernatant containing the disassembled coat proteins is applied on a SP Sepharose™ FF column (16/20, Amersham Biosciences) equilibrated with buffer B.", "The flow through is discarded.", "After an extensive wash with buffer B (15 CV) the column is adjusted with a linear gradient from buffer B to buffer C (20 mM NaPO4 pH 7.2, 1 M urea) with a gradient length of 37.5 CV.", "During the loading, wash and elution the absorbance at 254 nm and 280 nm is monitored.", "FR coat proteins are eluted as one fraction with buffer D (20 mM NaPO4 pH 6.5, 1 M urea, 300 mM NaCl) and analyzed by LDS-PAGE followed by Coomassie staining.", "The eluted protein fractions is stored at 4° C. as “disassembled coat protein”.", "Protein concentration is determined by Bradford analysis.", "Reassembly: Purified FR coat protein is used in a five fold excess (w/w) to G10 oligonucleotide.", "The FR coat proteins are mixed with the G10 oligonucleotide in a reassembly buffer containing 1 M urea and 2.5 mM DTT and incubated for one hour at room temperature.", "After incubation the reassembly mix is dialyzed for 24 hours against 5 liter PBS.", "The resulting suspension is centrifuged for 10 min, 27,000 g at 4° C. A negligible sediment is discarded.", "The supernatant contains the reassembled and packaged FR VLPs.", "Protein concentration is determined by Bradford analysis and the reassembled and packaged FR VLPs are concentrated with centrifugal filter devices (Amicon Ultra 15, 10K MWCO).", "Purification of Reassembled and Packaged FR VLPs: Up to 25 mg total protein is loaded onto a Sepharose™ CL-4B (26/60, Amersham Biosciences) equilibrated with PBS.", "Size exclusion chromatography is performed with equilibration buffer at room temperature with a flow rate of 1.25 ml/min.", "During the elution absorbance at 254 nm and 260 nm is monitored.", "Two peaks are isolated.", "A major high molecular weight peak precedes a small peak of lower apparent molecular weight.", "The major peak reveals a apparent molecular weight consistent to purified FR VLPs as shown by SE-HPLC.", "Analysis of FR VLPs packaged with G10 oligonucleotide is performed essentially as shown in Example 16 of WO 03/024481 (p. 131 ff).", "Example 14 Assembly of QβG-8 by Diafiltration and Determination of Yield Purified Qβ coat protein is obtained essentially as described in Example 8.Coat protein in 20 mM sodium phosphate pH 7.2, 250 mM NaCl is mixed with water and stock solutions of urea, NaCl, DTT and aggregated G8 oligonucleotide (prepared essentially as described in Example 3; relative peak start time of disaggregated G8 is 113%, relative peak start time of aggregated G8 is 88%).", "The volume of the mixture is 1.6 L and the final concentrations of the components are 1 mg/ml coat protein, 1.0 M urea, 250 mM NaCl, 2.5 mM DTT and 0.24 mg/ml G8.The solution is then diafiltrated at room temperature against 9.6 L of 20 mM sodium phosphate 250 mM NaCl pH 7.2, using a 30 kDa cut off cartridge (Pellicon Mini2, 0.1 m2 filter area, Millipore) and a cross flow rate of 384 L/(h*m2) and a permeate flow rate of 96 L/(h*m2).", "H2O2 is added to 2 mM final concentration and the solution is incubated for 1 h at RT in order to induce the formation of disulfide bonds.", "The solution is then diafiltrated against 16 L of 20 mM sodium phosphate 150 mM NaCl pH 7.2, using a 300 kDa cut off cartridge (Pellicon Mini 2, 0.1 m2 filter area, Millipore) and a cross flow rate of 300l/(h*m2) and a permeate flow rate of 100l/(h*m2), in order to remove excess of H2O2 and non-packaged G8 oligonucleotides from the assembled QβG8 product.", "The product is concentrated to 2.5 mg/ml by tangential flow filtration and filtered through a 0.22 μm filter." ] ]
Patent_15872594
[ [ "COLOR FILTER, METHOD OF MAKING THE SAME, AND DISPLAY DEVICE INCLUDING THE SAME", "A color filter including a first region configured to emit a first light, a second region configured to emit a second light having a longer wavelength than a wavelength of the first light, a third region configured to emit a third light having a longer wavelength than the wavelength of the second light, a first layer including two or more quantum dots, and a second layer formed on at least one surface of the first layer, wherein the first layer and the second layer are disposed in at least the second region and the third region." ], [ "1.A color filter comprising: a first region configured to emit a first light; a second region configured to emit a second light having a longer wavelength than a wavelength of the first light; a third region configured to emit a third light having a longer wavelength than the wavelength of the second light; a first layer comprising a quantum dot; and a second layer disposed on at least one surface of the first layer, wherein the first region, the second region, and the third region are spaced apart from each other by a predetermined distance, wherein the first layer is disposed to correspond to at least one of the second region and the third region, and the second layer is disposed to correspond to at least one of the second region and the third region, except for the first region, and wherein the second layer has light transmittance of greater than or equal to about 80 percent with respect to the first light.", "2.The color filter of claim 1, wherein the first layer is disposed to correspond to the second region and the third region, except for the first region.", "3.The color filter of claim 1, wherein the first layer which corresponds to the second region and the first layer which corresponds to the third region are spaced apart from each other.", "4.The color filter of claim 1, wherein the quantum dot comprises a first quantum dot, and a second quantum dot which emits different light to the first quantum dot.", "5.The color filter of claim 4, wherein the first quantum dot is disposed in the first layer which corresponds to the second region, and the first quantum dot is configured to emit the second light having a longer wavelength than the wavelength of the first light by absorbing the first light.", "6.The color filter of claim 5, wherein the second light having a center wavelength in a range of 520 nm to 540 nm, and a full width half maximum in a range of 40 nm to 60 nm.", "7.The color filter of claim 4, wherein the second quantum dot is disposed in the first layer which corresponds to the third region, and the second quantum dot is configured to emit the third light having a longer wavelength than the wavelength of the first light by absorbing the first light.", "8.The color filter of claim 7, wherein the third light having a center wavelength in a range of 615 nm to 635 nm, and a full width half maximum in a range of 40 nm to 60 nm.", "9.The color filter of claim 1, wherein the first light is blue light.", "10.The color filter of claim 1, wherein a thickness of the second layer is in a range of about 10 percent to about 60 percent of a thickness of the first layer.", "11.The color filter of claim 1, wherein each of the first layer and the second layer comprises a photosensitive resin.", "12.The color filter of claim 1, wherein the first layer further comprises a light diffusing agent selected from a metal oxide particle, a metal particle, and a combination thereof.", "13.The color filter of claim 1, wherein the quantum dot comprises a Group II-VI compound, a Group III-V compound, a Group IV-VI compound, a Group IV compound, a Group II-III-VI compound, a Group I-II-IV-VI compound, or a combination thereof.", "14.The color filter of claim 1, wherein the first region comprises a transparent body.", "15.The color filter of claim 1, wherein the color filter receives the first light from a light source in a first direction, and wherein in the color filter the first layer is disposed in front of the second layer in the first direction.", "16.A display device comprising: a color filter comprising: a first region configured to emit a first light; a second region configured to emit a second light having a longer wavelength than a wavelength of the first light; a third region configured to emit a third light having a longer wavelength than the wavelength of the second light; a first layer comprising a quantum dot; and a second layer disposed on at least one surface of the first layer, wherein the first region, the second region, and the third region are spaced apart from each other by a predetermined distance, and wherein the first layer is disposed to correspond to at least one of the second region and the third region, and wherein the second layer has light transmittance of greater than or equal to about 80 percent with respect to the first light; a light source configured to emit the first light in a first direction; a first substrate disposed in front of the light source in the first direction; the color filter disposed in front of the first substrate in the first direction; and a second substrate disposed in front of the color filter in the first direction, wherein in the color filter the first layer is disposed in front of the second layer in the first direction.", "17.The display device of claim 16, wherein the quantum dot comprises a first quantum dot, and a second quantum dot which emits different light to the first quantum dot.", "18.The display device of claim 17, wherein the first quantum dot is disposed in the first layer which corresponds to the second region, and the first quantum dot is configured to emit the second light having a longer wavelength than the wavelength of the first light by absorbing the first light.", "19.The display device of claim 18, wherein the second light having a center wavelength in a range of 520 nm to 540 nm, and a full width half maximum in a range of 40 nm to 60 nm.", "20.The display device of claim 17, wherein the second quantum dot is disposed in the first layer which corresponds to the third region, and the second quantum dot is configured to emit the third light having a longer wavelength than the wavelength of the first light by absorbing the first light.", "21.The display device of claim 20, wherein the third light having a center wavelength in a range of 615 nm to 635 nm, and a full width half maximum in a range of 40 nm to 60 nm.", "22.The display device of claim 16, further comprising a first polarizing plate disposed in front of the first substrate in the first direction, and a second polarizing plate disposed in rear of the second substrate in the first direction.", "23.The display device of claim 16, wherein the display device is at least one of a liquid crystal display device, an organic light emitting diode display device, or a light emitting diode display.", "24.The display device of claim 23, wherein the display device is the liquid crystal display device, and the display device further comprises a liquid crystal layer interposed between the first substrate and the color filter or between the color filter and the second substrate." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>An exemplary embodiment provides a color filter including a first region configured to emit a first light, a second region configured to emit a second light that has a longer wavelength than a wavelength of the first light, a third region configured to emit a third light that has a longer wavelength than the wavelength of the second light, a first layer including two or more quantum dots, and a second layer disposed on at least one surface of the first layer, wherein the first layer and the second layer are disposed in at least the second region and the third region.", "The second layer may have light transmittance of greater than or equal to about 80% with respect to the first light.", "The first light may be blue light.", "A thickness of the second layer may be in a range of about 10% to about 60% of a thickness of the first layer.", "Each of the first layer and the second layer may include a photosensitive resin.", "The first layer may further include a light diffusing agent selected from a metal oxide particle, a metal particle, and a combination thereof.", "The quantum dots may include a Group II-VI compound, a Group III-V compound, a Group IV-VI compound, a Group IV compound, a Group II-III-VI compound, a Group I-II-IV-VI compound, or a combination thereof.", "The quantum dots may include a plurality of first quantum dots disposed in the second region and configured to emit the second light having a longer wavelength than the wavelength of the first light by absorbing the first light, and a plurality of second quantum dots disposed in the third region and configured to emit the third light having a longer wavelength than the wavelength of the first light and the wavelength of the second light by absorbing the first light.", "The first region is includes a transparent body.", "Another embodiment provides a method of manufacturing the color filter, the method including forming the first layer on a substrate, forming the second layer on the first layer to obtain a stacked body in which the first layer and the second layer are disposed on the substrate, pre-baking the stacked body, patterning the stacked body to obtain a patterned stacked body, and post-baking the patterned stacked body.", "The pre-baked stacked body has a first retention of about 70% to about 100%, wherein the first retention is a percentage of a light conversion rate of the post-baked stacked body with respect to a light conversion rate of the pre-baked stacked body.", "The manufacturing method of the color filter may further include aging the stacked body.", "The aged stacked body has a second retention of about 85% to about 100%, wherein the second retention is a percentage of a light conversion rate of the aged stacked body with respect to a light conversion rate of the pre-baked stacked body.", "The aged stacked body has a third retention of about 100% to about 120%, wherein the third retention is a percentage of a light conversion rage of the aged stacked body with respect to a light conversion rate of the post-baked stacked body.", "Yet another embodiment provides a display device including the color filter, the display device including a light source configured to emit the first light in a first direction, a first substrate disposed in front of the light source in the first direction, the color filter disposed in front of the first substrate in the first direction, and a second substrate disposed in front of the color filter in the first direction, wherein in the color filter the first layer is disposed in front of the second layer in the first direction.", "The display device may further include a liquid crystal layer interposed between the first substrate and the color filter or between the color filter and the second substrate.", "Accordingly, the luminous efficiency deterioration which may occur in a manufacturing process of the color filter may be minimized, and a color filter having excellent luminous efficiency may be provided.", "Further, by including the color filter in the display device, both the viewing angle and the luminous efficiency with respect to power consumption of a liquid crystal display device, may be improved." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. application Ser.", "No.", "15/206,718, filed on Jul.", "11, 2016, which claims priority to and the benefit of Korean Patent Application No.", "10-2015-0180233, filed in the Korean Intellectual Property Office on Dec. 16, 2015, and all the benefits accruing therefrom under 35 U.S.C.", "§ 119, the contents of which in their entirety are herein incorporated by reference.", "BACKGROUND 1.Field The described technology relates to a color filter, a manufacturing method thereof, and a display device including the color filter.", "2.Description of the Related Art A liquid crystal display device (LCD) implements a color by transmitting polarized light which has passed through a liquid crystal layer through an absorptive color filter.", "The LCD has a viewing angle which is narrow and luminance which is lowered due to low light transmittance of the absorptive color filter.", "However, when a photoluminescent type of color filter replaces the absorptive color filter, the viewing angle thereof may be widened and the luminance thereof may be improved.", "However, in the case of such a photoluminescent type of color filter, a luminous efficiency deterioration phenomenon has been reported.", "That is, luminous efficiency of a manufactured photoluminescent type of color filter does not reach that of an initially designed ideal photoluminescent type of color filter.", "Therefore, it is desirable to develop a technique that may minimize the luminous efficiency deterioration phenomenon in a manufacturing process of the photoluminescent type of color filter.", "The above information disclosed in this Background section is only for enhancement of understanding of the background of the described technology and therefore it may contain information that does not form the prior art that is already known in this country to a person of ordinary skill in the art.", "SUMMARY An exemplary embodiment provides a color filter including a first region configured to emit a first light, a second region configured to emit a second light that has a longer wavelength than a wavelength of the first light, a third region configured to emit a third light that has a longer wavelength than the wavelength of the second light, a first layer including two or more quantum dots, and a second layer disposed on at least one surface of the first layer, wherein the first layer and the second layer are disposed in at least the second region and the third region.", "The second layer may have light transmittance of greater than or equal to about 80% with respect to the first light.", "The first light may be blue light.", "A thickness of the second layer may be in a range of about 10% to about 60% of a thickness of the first layer.", "Each of the first layer and the second layer may include a photosensitive resin.", "The first layer may further include a light diffusing agent selected from a metal oxide particle, a metal particle, and a combination thereof.", "The quantum dots may include a Group II-VI compound, a Group III-V compound, a Group IV-VI compound, a Group IV compound, a Group II-III-VI compound, a Group I-II-IV-VI compound, or a combination thereof.", "The quantum dots may include a plurality of first quantum dots disposed in the second region and configured to emit the second light having a longer wavelength than the wavelength of the first light by absorbing the first light, and a plurality of second quantum dots disposed in the third region and configured to emit the third light having a longer wavelength than the wavelength of the first light and the wavelength of the second light by absorbing the first light.", "The first region is includes a transparent body.", "Another embodiment provides a method of manufacturing the color filter, the method including forming the first layer on a substrate, forming the second layer on the first layer to obtain a stacked body in which the first layer and the second layer are disposed on the substrate, pre-baking the stacked body, patterning the stacked body to obtain a patterned stacked body, and post-baking the patterned stacked body.", "The pre-baked stacked body has a first retention of about 70% to about 100%, wherein the first retention is a percentage of a light conversion rate of the post-baked stacked body with respect to a light conversion rate of the pre-baked stacked body.", "The manufacturing method of the color filter may further include aging the stacked body.", "The aged stacked body has a second retention of about 85% to about 100%, wherein the second retention is a percentage of a light conversion rate of the aged stacked body with respect to a light conversion rate of the pre-baked stacked body.", "The aged stacked body has a third retention of about 100% to about 120%, wherein the third retention is a percentage of a light conversion rage of the aged stacked body with respect to a light conversion rate of the post-baked stacked body.", "Yet another embodiment provides a display device including the color filter, the display device including a light source configured to emit the first light in a first direction, a first substrate disposed in front of the light source in the first direction, the color filter disposed in front of the first substrate in the first direction, and a second substrate disposed in front of the color filter in the first direction, wherein in the color filter the first layer is disposed in front of the second layer in the first direction.", "The display device may further include a liquid crystal layer interposed between the first substrate and the color filter or between the color filter and the second substrate.", "Accordingly, the luminous efficiency deterioration which may occur in a manufacturing process of the color filter may be minimized, and a color filter having excellent luminous efficiency may be provided.", "Further, by including the color filter in the display device, both the viewing angle and the luminous efficiency with respect to power consumption of a liquid crystal display device, may be improved.", "BRIEF DESCRIPTION OF THE DRAWINGS The above and other aspects, advantages and features of this disclosure will become more apparent by describing in further detail exemplary embodiments thereof with reference to the accompanying drawings, in which: FIG.", "1 is a schematic illustration showing an effect of a second layer in a color filter on ameliorating luminous efficiency deterioration according to an exemplary embodiment; FIG.", "2 is an illustration of the color filter in FIG.", "1; FIG.", "3 is a cross-sectional illustration of a display device including the color filter of FIG.", "2; and FIG.", "4 is a flowchart showing a method of manufacturing the color filter of FIG.", "2.DETAILED DESCRIPTION Hereinafter, the described technology will be described more fully with reference to the accompanying drawings, in which exemplary embodiments are shown.", "As those skilled in the art would realize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the described technology.", "In the drawings, the thicknesses of layers, films, panels, regions, etc., are exaggerated for clarity.", "Like reference numerals designate like elements throughout the specification.", "It will be understood that when an element such as a layer, film, region, or substrate is referred to as being “on” another element, it can be directly on the other element or intervening elements may also be present.", "In contrast, when an element is referred to as being “directly on” another element, there are no intervening elements present.", "The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting.", "As used herein, the singular forms “a,” “an,” and “the” are intended to include the plural forms, including “at least one,” unless the content clearly indicates otherwise.", "“At least one” is not to be construed as limiting “a” or “an.” It will be further understood that the terms “comprises” and/or “comprising,” or “includes” and/or “including” when used in this specification, specify the presence of stated features, regions, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, regions, integers, steps, operations, elements, components, and/or groups thereof.", "It will be understood that, although the terms “first,” “second,” “third,” etc.", "may be used herein to describe various elements, components, regions, layers, and/or sections, these elements, components, regions, layers, and/or sections should not be limited by these terms.", "These terms are only used to distinguish one element, component, region, layer, or section from another element, component, region, layer, or section.", "Thus, “a first element,” “component,” “region,” “layer,” or “section” discussed below could be termed a second element, component, region, layer, or section without departing from the teachings herein.", "Furthermore, relative terms, such as “lower” or “bottom” and “upper” or “top,” may be used herein to describe one element's relationship to another element as illustrated in the Figures.", "It will be understood that relative terms are intended to encompass different orientations of the device in addition to the orientation depicted in the Figures.", "For example, if the device in one of the figures is turned over, elements described as being on the “lower” side of other elements would then be oriented on “upper” sides of the other elements.", "The exemplary term “lower,” can therefore, encompasses both an orientation of “lower” and “upper,” depending on the particular orientation of the figure.", "Similarly, if the device in one of the figures is turned over, elements described as “below” or “beneath” other elements would then be oriented “above” the other elements.", "The exemplary terms “below” or “beneath” can, therefore, encompass both an orientation of above and below.", "“About” or “approximately” as used herein is inclusive of the stated value and means within an acceptable range of deviation for the particular value as determined by one of ordinary skill in the art, considering the measurement in question and the error associated with measurement of the particular quantity (i.e., the limitations of the measurement system).", "For example, “about” can mean within one or more standard deviations, or within ±30%, 20%, 10%, or 5% of the stated value.", "Unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs.", "It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and the present disclosure, and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.", "Exemplary embodiments are described herein with reference to cross section illustrations that are schematic illustrations of idealized embodiments.", "As such, variations from the shapes of the illustrations as a result, for example, of manufacturing techniques and/or tolerances, are to be expected.", "Thus, embodiments described herein should not be construed as limited to the particular shapes of regions as illustrated herein but are to include deviations in shapes that result, for example, from manufacturing.", "For example, a region illustrated or described as flat may, typically, have rough and/or nonlinear features.", "Moreover, sharp angles that are illustrated may be rounded.", "Thus, the regions illustrated in the figures are schematic in nature and their shapes are not intended to illustrate the precise shape of a region and are not intended to limit the scope of the present claims.", "Quantum dots (QD) may be applied to various display devices as a complex in which quantum dots are dispersed in a polymer host matrix.", "The quantum dots may be employed in a light emitting diode (LED) or the like as a light converting layer by being dispersed in a host matrix formed of a polymer or an inorganic material.", "In the case of the quantum dots, it is possible to uniformly adjust particle sizes and relatively freely adjust the particle sizes in colloid synthesis.", "When the particle sizes of the quantum dots are equal to or less than about 10 nanometers (nm), a quantum confinement effect indicating that an energy band gap increases as the size decreases becomes prominent, thereby increasing energy density.", "Since the quantum dots may have theoretical quantum efficiency (QY) of about 100% and may emit light at a high color purity (e.g., a full width half maximum (FWHM) of about 40 nm or less), they improve light emitting efficiency and color reproducibility.", "Accordingly, the quantum dots may be applied to diverse display devices, if they can be patterned.", "Further, among such diverse applications, they may contribute to development of a high quality photoluminescent type of LCD in the case of being employed for a color filter of the LCD.", "Hereinafter, a part of a color filter in which a first layer and a second layer are formed according to an exemplary embodiment will be schematically described, and an effect of ameliorating luminous efficiency deterioration by the schematic structure of the first layer and the second layer will be described.", "FIG.", "1 schematically illustrates the ameliorating effect of the second layer in the color filter on the luminous efficiency deterioration according to the exemplary embodiment.", "Referring to FIG.", "1, a color filter 100 is a stacked structure including a first layer 10 and a second layer 20 disposed on at least one surface of the first layer 10.The first layer 10 includes two or more quantum dots 11, and the quantum dots 11 are dispersed in the first layer 10.Since the quantum dots 11 have an isotropic radiation characteristic, the quantum dots 11 may radiate light in a radial direction when an energy state of the quantum dots is excited (e.g.", "elevated in energy) by incident light received from a light source and then returned to a ground state.", "Therefore, the first layer 10 including the quantum dots 11 may be employed as a light emitting layer.", "In FIG.", "1, a double-lined arrow represents a path of incident light, and a solid-lined arrow represents a path of radiated light.", "Since the quantum dots 11 have a discrete energy band gap caused by a quantum confinement effect, the quantum dots 11 may radiate light having a certain wavelength range by receiving the incident light.", "Accordingly, since the first layer 10 includes two or more of the quantum dots 11, the first layer 10 according to the present exemplary embodiment may display an image at higher color purity than the first layer including a different light emitting material.", "The first layer 10 may further include light diffusing agents 12.The light diffusing agents 12 may be dispersed in the first layer 10 together with the quantum dots 11.The light diffusing agents 12 may guide the incident light to the quantum dots 11 or may guide the light radiated from the quantum dots 11 outside of the first layer 10.Accordingly, luminous efficiency deterioration of the first layer 10 may be minimized.", "In FIG.", "1, a two-point chain lined arrow represents a path of light guided by the light diffusing agents 12.For example, the second layer 20 may be disposed on one surface of the first layer 10, serving as an incident surface into which the incident light is introduced as shown in FIG.", "1, but it is not limited thereto.", "Alternatively, the second layer 20 may be disposed on each of opposite surfaces of the first layer 10.The second layer 20 may be formed of an optically transparent material.", "For example, the second layer 20 may be formed of a material having excellent light transmittance for a certain wavelength range.", "For example, when the incident light illustrated in FIG.", "1 is blue light that has a wavelength range of about 500 nanometers (nm) or less, the second layer 20 may be formed of a material having excellent light transmittance for a wavelength range of about 500 nm or more.", "For example, the second layer 20 may be formed of a material having light transmittance of about 80% or more, about 85% or more, or about 90% or more, for light having the wavelength range of about 500 nm or less.", "Further, for example, the second layer 20 may be formed to have a similar refractive index to that of the first layer 10.Accordingly, a case where the incident light introduced into the second layer 20 is reflected or scattered by the second layer 20 may be minimized.", "In other words, an optical loss generated at an interface between the second layer 20 and the first layer 10 may be minimized.", "In the present exemplary embodiment, the second layer 20 is formed as a single layer on the first layer 10 as shown in FIG.", "1, but the present exemplary embodiment is not limited thereto.", "For example, the second layer 20 may be formed as a multilayer including two or more layers.", "In the present exemplary embodiment, the second layer 20 may reflect some of the radiated light, which returns toward the light source due to an isotropic radiation characteristic of the quantum dots 11, to guide it in an opposite direction to that of the second layer 20.In FIG.", "1, a one-point chain lined arrow represents a path of reflected light which is reflected by the second layer 20, and a dash lined arrow represents a path of transmitted light, which returns to the light source by being transmitted through the second layer 20.For example, when the second layer 20 is interposed between the first layer 10 and the light source as in the present exemplary embodiment, light-recycling of the radiated light may be possible by reflecting some of the radiated light, which returns toward the light source due to the isotropic radiation characteristic of the quantum dots 11, thereby allowing the light to remain in the first layer 10 by guiding it in the opposite direction to that of the second layer 20, or the like.", "As a result, the second layer 20 may serve as an optical barrier layer that compensates for the luminous efficiency of the first layer 10, e.g., the light emitting layer.", "Accordingly, it is possible to provide a color filter that may minimize luminous efficiency deterioration.", "A thickness of the second layer 20 may be in a range of about 5% to about 100%, or about 10% to about 60%, of the thickness of the first layer 10.When the second layer 20 has a thickness that is less than about 5% of the thickness of the first layer 10, the ameliorating effect of the luminous efficiency deterioration of the first layer 10 by the action of the second layer 20 may be insignificant, and when the second layer 20 has a thickness exceeding about 100% of the thickness of the first layer 10, a light loss of the incident light due to the action of the second layer 20 may be increased.", "However, the aforementioned light-recycling of the radiated light by the action of the second layer 20 may be effectively performed by forming the second layer 20 to have the thickness in the above-described range.", "Hereinafter, materials of the first layer 10 and the second layer 20 in the color filter 100 according to the present exemplary embodiment will be described.", "In the present exemplary embodiment, each of the first layer 10 and the second layer 20 may be formed of a photosensitive resin.", "Accordingly, the color filter 100 may be readily patterned by a photolithographic method.", "In the present exemplary embodiment, the photosensitive resins used to form the first layer 10 and the second layer 20 may each include a binder, a photopolymerization monomer including a carbon-carbon double bond, a photoinitiator, a solvent, and a curing agent in common.", "In the present exemplary embodiment, the binder may be a carboxylic binder including a carboxyl group (—COOH).", "For example, the binder may be a copolymer of a monomer mixture that includes a first monomer including the carboxyl group and the carbon-carbon double bond, and a second monomer including the carbon-carbon double bond and a hydrophobic moiety but not a carboxyl group.", "The quantum dots 11 are dispersed, e.g., spaced apart from each other, in the first layer 10 by the binder including a carboxyl group to form a quantum dot-polymer complex structure.", "For example, the first monomer may include a compound including a carboxylic acid, an ethylenically unsaturated group such as acrylic acid, methacrylic acid, maleic acid, itaconic acid, fumaric acid, 3-butenoic acid, vinyl acetate, vinyl benzoic acid, or the like, but it is not limited thereto.", "The first monomer may include one or more compounds.", "For example, the second monomer may include an alkenyl aromatic compound such as styrene, alpha-methyl styrene, vinyl toluene, vinyl benzyl methyl ether, or the like; an unsaturated carboxylic acid ester compound such as methyl acrylate, methyl methacrylate, ethyl acrylate, ethyl methacrylate, butyl acrylate, butyl methacrylate, benzyl acrylate, benzyl methacrylate, cyclohexyl acrylate, cyclohexyl methacrylate, phenyl acrylate, phenyl methacrylate, or the like; an unsaturated carboxylic acid amino alkyl ester compound such as 2-amino ethyl acrylate, 2-amino ethyl methacrylate, 2-dimethyl amino ethyl acrylate, N-phenylmaleimide, N-benzylmaleimide, N-alkylmaleimide, 2-dimethyl amino ethyl methacrylate, or the like; an unsaturated carboxylic acid glycidyl ester compound such as glycidyl acrylate, glycidyl methacrylate, or the like; a cyano-substituted vinyl compound such as acrylonitrile, methacrylonitrile, or the like; and an unsaturated amide compound such as acrylamide, methacrylamide, or the like, but it is not limited thereto.", "One or more compounds may be employed as the second monomer.", "The photoinitiator initiates photopolymerization between the above photopolymerization monomers.", "In the present exemplary embodiment, the photoinitiator may include a triazine-based compound, an acetophenone-based compound, a benzophenone-based compound, a thioxanthone-based compound, a benzoin-based compound, an oxime-based compound, or a combination thereof, but is not limited thereto.", "Examples of the triazine-based compound may include 2,4,6-trichloro-s-triazine, 2-phenyl-4,6-bis(trichloromethyl)-s-triazine, 2-(3′,4′-dimethoxy-styryl)-4,6-bis(trichloromethyl)-s-triazine, 2-(4′-methoxy-naphthyl)-4,6-bis(trichloromethyl)-s-triazine, 2-(p-methoxyphenyl)-4,6-bis(trichloromethyl)-s-triazine, 2-(p-tolyl)-4,6-bis(trichloromethyl)-s-triazine, 2-biphenyl-4,6-bis(trichloromethyl)-s-triazine, bis(trichloromethyl)-6-styryl-s-triazine, 2-(naphtho-1-il)-4,6-bis(trichloromethyl)-s-triazine, 2-(4-methoxy-naphtho-1-il)-4,6-bis(trichloromethyl)-s-triazine, 2,4-trichloromethyl(piperonyl)-6-triazine, or 2,4-(trichloromethyl(4′-methoxystyryl)-6-triazine, but they are not limited thereto.", "Examples of the acetophenone-based compound may include 2,2′-diethoxyacetophenone, 2,2′-dibutoxyacetophenone, 2-hydroxy-2-methylpropiophenone, p-t-butyl trichloroacetophenone, p-t-butyl dichloroacetophenone, 4-chloroacetophenone, 2,2′-dichloro-4-phenoxy acetophenone, 2-methyl-1-(4-(methylthio)phenyl)-2-morpholino propane-1-on, 2-benzyl-2-dimethylamino-1-(4-morpholinophenyl)-butan-1-on, or the like, but they are not limited thereto.", "Examples of the benzophenone-based compound may include benzophenone, benzoyl benzoic acid, benzoyl benzoic acid methyl, 4-phenyl benzophenone, hydroxy benzophenone, acrylic-benzophenone, 4,4′-bis(dimethylamino)benzophenone, 4,4′-dichlorobenzophenone, 3,3′-dimethyl-2-methoxy benzophenone, or the like, but they are not limited thereto.", "Examples of the thioxanthone-based compound may include thioxanthone, 2-methyl thioxanthone, isopropylthioxanthone, 2,4-diethyl thioxanthone, 2,4-diisopropyl thioxanthone, 2-chloro thioxanthone, or the like, but they are not limited thereto.", "Examples of the benzoin-based compound may include benzoin, benzoin methyl ether, benzoin ethyl ether, benzoin isopropyl ether, benzoin isobutyl ether, benzyl dimethyl ketal, or the like, but they are not limited thereto.", "Examples of the oxime-based compound may include 2-(o-benzoyloxime)-1-[4-(phenylthio)phenyl]-1,2-octandione or 1-(o-acetyloxime)-1-[9-ethyl-6-(2-methylbenzoyl)-9H-carbazole-3-il]ethanone, but they are not limited thereto.", "In addition to the above photoinitiator, a carbazole-based compound, a diketone-based compound, a sulfonium borate-based compound, a diazo-based compound, a biimidazole-based compound, or the like, or a combination thereof may be employed as the photoinitiator.", "In the present exemplary embodiment, a photosensitive composition may include diverse additives such as a leveling agent, a coupling agent, and the like.", "An amount of the additives is not particularly limited, and may be appropriately adjusted by a skilled person without undue experimentation to be within a range which does not adversely affect the photosensitive composition or a pattern formed therefrom.", "The leveling agent serves to prevent the formation of stains and spots in a film and to improve a leveling characteristic of the film.", "Detailed examples of the leveling agent will be described as follows, but they are not limited thereto.", "The examples of the leveling agent may include a commercial product of a fluorine-based leveling agent such as BM-1000®, BM-1100®, or the like (BM Chemie Group); MEGAFACE F 142D®, MEGAFACE F 172®, MEGAFACE F 173®, MEGAFACE F 183®, or the like (Dainippon Ink Kagaku Kogyo Co., Ltd.); FULORAD FC-135®, FULORAD FC-170C®, FULORAD FC-430®, FULORAD FC-431®, or the like (Sumitomo 3M Co., Ltd.); SURFLON S-112®, SURFLON S-113®, SURFLON S-131®, SURFLON S-141®, SURFLON S-145®, or the like (Asahi Glass Co., Ltd.); or SH-28PA®, SH-190®, SH-193®, SZ-6032®, SF-8428®, or the like (Toray Silicone Co., Ltd.).", "The leveling agent may be readily adjusted by a skilled person without undue experimentation depending on a desired property.", "The coupling agent serves to improve adhesion to the substrate, and may include a silane-based coupling agent.", "Detailed examples of the silane-based coupling agent may include vinyl trimethoxysilane, vinyl tris(2-methoxyethoxysilane), 3-glycidoxypropyltrimethoxysilane, 2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane, 3-chloropropylmethyldimethoxysilane, 3-chloropropyltrimethoxysilane, 3-methacryloxypropyltrimethoxysilane, 3-mercaptopropyltrimethoxysilane, or the like, or a combination thereof may be used.", "In the present exemplary embodiment, the amount of the solvent may be appropriately adjusted in consideration of the amounts of the aforementioned elements (the binder, the photopolymerization monomer, the photoinitiator, and the additives) and/or amounts of the quantum dots 11, and the light diffusing agents 12, which will be described later.", "Specifically, the amount of the solvent is the amount of the photosensitive resin excluding the amount of a solid component (non-volatile component), and may be appropriately adjusted in consideration of the compatibility of the solvent with other components (e.g., the binder, the photopolymerization monomer, the photoinitiator, the additives, and/or the quantum dots and light diffusing agent), compatibility of the solvent with an alkali development solution, a boiling temperature of the solvent, and the like.", "Examples of the solvent may include an ethylene glycol compound such as ethyl 3-ethoxypropionate, ethylene glycol, diethylene glycol, polyethylene glycol, or the like; a glycol ether compound such as ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, diethylene glycol monomethyl ether, ethylene glycol diethyl ether, diethylene glycol dimethyl ether, or the like; a glycol ether acetate compound such as ethylene glycol acetate, ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, or the like; a propylene glycol compound such as propylene glycol or the like; a propylene glycol ether compound such as propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, propylene monobutyl ether, propylene glycol dimethyl ether, dipropylene glycol dimethyl ether, propylene glycol diethyl ether, dipropylene glycol diethyl ether, or the like; a propylene glycol ether acetate compound such as propylene glycol monomethyl ether acetate, dipropylene glycol monoethyl ether acetate, or the like; an amide compound such as N-methylpyrrolidone, dimethylformamide, dimethylacetamide, or the like; a ketone compound such as methyl ethyl ketone (MEK), methyl isobutyl ketone (MIBK), cyclohexanone, or the like; a petroleum compound such as toluene, xylene, solvent naphtha, or the like; an ester compound such as ethyl acetate, butyl acetate, ethyl lactate, or the like; an ether compound such as diethyl ether, dipropyl ether, dibutyl ether, or the like; and a combination thereof.", "In the present exemplary embodiment, the curing agent may include a thiol-based curing agent.", "The thiol-based curing agent may be a compound including one or more thiol groups that react with the carbon-carbon double bond of the photopolymerization monomer and which reacts primarily with the photopolymerization monomer during a heat-curing process.", "In the present exemplary embodiment, the thiol-based curing agent is not particularly limited as long as it includes at least one thiol group in its molecular structure.", "In the present exemplary embodiment, examples of the thiol curing agent may include ethoxylated trimethylolpropane tris(3-mercaptopropionate), trimethylolpropane tris(3-mercaptopropionate), glycol di(3-mercaptopropionate), pentaerythritol tetra(3-mercaptopropionate), 4-mercaptomethyl-3,6-dithia-1,8-octanedithiol, pentaerythritol tetrakis(3-mercaptoacetate), trimethylol propane tris(3-mercaptoacetate), 4-t-butyl-1,2-benzenedithiol, 2-mercaptoethylsulfide, 4,4′-thiodibenzenethiol, benzenedithiol, glycol dimercaptoacetate, glycol dimercaptopropionate ethylene bis(3-mercaptopropionate), polyethylene glycol dimercaptoacetate, polyethylene glycol di(3-mercaptopropionate), or the like, or a combination thereof.", "The thiol curing agent may primarily serve to heat-cure the photosensitive resin during a pre-baking step or the like, and may also serve, for example, to prevent damage to the quantum dots inside the photosensitive resin of which the first layer is formed throughout an entire process of manufacturing the color filter.", "The photosensitive resin for forming the first layer 10 may further include the aforementioned quantum dots 11 and light diffusing agents 12 in addition to the above components.", "As a result, the first layer 10 may have a light emitting characteristic since the first layer 10 further includes the quantum dots 11, and the ameliorating effect of the first layer 10 on the luminous efficiency deterioration may be improved since the first layer 10 further includes the light diffusing agents 12.In the present exemplary embodiment, the quantum dots 11 are not particularly limited, and any known or commercially available quantum dots may be employed.", "For example, the quantum dots 11 may include a Group II-VI compound, a Group III-V compound, a Group IV-VI compound, a Group IV compound, a Group II-III-VI compound, a Group I-II-IV-VI compound, or a combination thereof, wherein each Group refers to a Group of the Periodic Table of the Elements.", "For the Group II-VI compound, a binary compound selected from CdSe, CdTe, ZnS, ZnSe, ZnTe, ZnO, HgS, HgSe, HgTe, MgSe, MgS, and a combination thereof; a ternary compound selected from CdSeS, CdSeTe, CdSTe, ZnSeS, ZnSeTe, ZnSTe, HgSeS, HgSeTe, HgSTe, CdZnS, CdZnSe, CdZnTe, CdHgS, CdHgSe, CdHgTe, HgZnS, HgZnSe, HgZnTe, MgZnSe, MgZnS, and a combination thereof; or a quaternary compound selected from HgZnTeS, CdZnSeS, CdZnSeTe, CdZnSTe, CdHgSeS, CdHgSeTe, CdHgSTe, HgZnSeS, HgZnSeTe, HgZnSTe, and a combination thereof, may be employed.", "For the Group III-V compound, a binary compound selected from GaN, GaP, GaAs, GaSb, AlN, AlP, AlAs, AlSb, InN, InP, InAs, InSb, and a combination thereof; a ternary compound selected from GaNP, GaNAs, GaNSb, GaPAs, GaPSb, AlNP, AlNAs, AlNSb, AlPAs, AlPSb, InNP, InNAs, InNSb, InPAs, InPSb, and a combination thereof; or a quaternary compound selected from GaAlNP, GaAlNAs, GaAlNSb, GaAlPAs, GaAlPSb, GaInNP, GaInNAs, GaInNSb, GaInPAs, GaInPSb, InAlNP, InAlNAs, InAlNSb, InAlPAs, InAlPSb, and a combination thereof, may be employed.", "For the Group IV-VI compound, a binary compound selected SnS, SnSe, SnTe, PbS, PbSe, PbTe, and a combination thereof; a ternary compound selected from SnSeS, SnSeTe, SnSTe, PbSeS, PbSeTe, PbSTe, SnPbS, SnPbSe, SnPbTe, and a combination thereof; or a quaternary compound selected from SnPbSSe, SnPbSeTe, SnPbSTe, and a combination thereof, may be employed.", "Examples of the Group I-III-VI compound may include CuInSe2, CuInS2, CuInGaSe, or CuInGaS, or a combination thereof, but they are not limited thereto.", "Examples of the Group I-II-IV-VI compound may include CuZnSnSe, CuZnSnS, or a combination thereof, but they are not limited thereto.", "For the Group IV compound, a unary compound selected from Si, Ge, and a combination thereof; and a binary compound selected from SiC, SiGe, and a combination thereof, may be employed.", "The binary compound, the ternary compound, or the quaternary compound may exist in a uniform concentration or in a partially different concentration in the quantum dot particles.", "In the present exemplary embodiment, the quantum dots may have a core/shell structure in which one quantum dot surrounds another quantum dot.", "An interface between a core and a shell may have a concentration gradient such that a concentration of an element in the shell decreases toward a center of the quantum dot.", "Further, the quantum dots may have a structure including a semiconductor nanocrystal core and a multi-layered shell which surrounds the semiconductor nanocrystal core.", "In this case, the multi-layered shell may have two or more layers each of which may include a single composition or an alloy, or a concentration gradient.", "Further, the quantum dots may have a structure in which a composition of the shell has a larger energy band gap than that of the core, thereby enhancing the quantum confinement effect.", "Also in the case of the multi-layered shell, the composition of an outer shell may have a larger energy band gap than that of an inner shell.", "In this case, the quantum dots may have a wavelength excitation range from an ultraviolet region to an infrared region.", "The quantum dots may have a quantum efficiency of about 10% or more, for example, about 30% or more, about 50% or more, about 60% or more, about 70% or more, or about 90% or more.", "Further, the quantum dots may have a narrow spectrum to improve color purity or color reproducibility of the display device.", "The quantum dots may have a full width at half maximum (FWHM) of a light emitting spectrum of about 45 nm, or, for example, about 40 nm or more, or about 30 nm or more.", "In this range, the color purity and the color reproducibility of the display device may be improved.", "The quantum dots 11 are spherically illustrated in FIG.", "1 for convenience of illustration, but are not limited thereto.", "The quantum dots 11 may have any general shape in the art and are not particularly limited.", "For example, the quantum dots may be a nanoparticle having a spherical shape, a pyramid shape, a multi-arm shape, or a cube shape, or may be a nanotube shape, a nanowire shape, a nanofiber shape, or a nanosheet shape.", "The quantum dots may have a diameter that is in a range of about 1 nm to about 100 nm.", "For example, in the present exemplary embodiment, the quantum dots may have a diameter that is in a range of about 1 nm to about 20 nm, for example, about 2 nm to about 15 nm, or about 3 nm to about 15 nm.", "In the case where the quantum dots have a non-spherical shape, the diameter refers to the furthest distance between two points on the quantum dots.", "The light diffusing agents 12 may minimize the luminous efficiency deterioration due to the isotropic radiation characteristic in the first layer 10, since the light diffusing agents 12 diffuse the incident light in various directions in the first layer 10 as described above.", "The light diffusing agents 12 may include inorganic oxide particles such as alumina particles, silica particles, zirconia particles, zinc oxide particles, titanium oxide particles, or metal particles such as gold particles, silver particles, copper particles, platinum particles, or a combination thereof, but they are not limited thereto.", "As such, the first layer 10 and the second layer 20 according to the present exemplary embodiment include a photosensitive material formed of the above-described photosensitive resin.", "Accordingly, a photolithographic pattern formed of a quantum dot-polymer complex can be readily formed by the photolithographic method, even when the quantum dots 11 do not include a photopolymerization functional group (e.g., the carbon-carbon double bond such as methacrylate, acrylate, or the like).", "Further, a surface treatment of the quantum dot may be omitted, and use of an organic solvent may be excluded when a development process, which will be described later, is performed.", "Hereinafter, a detailed structure of the color filter 100 according to an exemplary embodiment will be described with reference to FIG.", "2.FIG.", "2 specifically illustrates the color filter of FIG.", "1.In the present exemplary embodiment, the color filter 100 may be divided into a first region PX1 for displaying first light, a second region PX2 for displaying second light, and a third region PX3 for displaying third light.", "Each region is separated by light blocking members 403.Further, the first region PX1, the second region PX2, and the third region PX3 are regularly arranged in a predetermined form.", "For example, in a direction from a left side to a right side in FIG.", "2, an arrangement in which the first region PX1, the third region PX3, and the second region PX2 are sequentially disposed is referred to as one unit region.", "Two or more unit regions may be regularly and repeatedly arranged.", "Further, such unit regions may be repeatedly arranged in a two dimensional form, e.g., in a matrix shape.", "However, the arrangement sequence, direction, and the like of the first region PX1 to the third region PX3 may be diversely determined.", "In the present exemplary embodiment, in the color filter 100, the first region PX1 may display blue light as the first light, the second region PX2 may display green light as the second light, and the third region PX3 may display red light as the third light.", "The color filter 100 may be a “blue-light color filter” that displays blue light, green light, and red light by receiving the first light.", "As a result, the first layer 10 and the second layer 20 may not be formed in the first region PX1 that displays blue light, and may instead be formed in each of the second region PX2 and the third region PX3.The first region PX1 may be filled with transparent bodies.", "However, an operation of the color filter and a configuration depending on the operation are not limited thereto, and the color filter may display blue light, green light, and red light by receiving white light or ultraviolet light.", "In this case, the first layer 10 and the second layer 20 may be formed in each of the first region PX1 to the third region PX3.Hereinafter, the color filter 100 according to the present exemplary embodiment will be described using the “blue-light color filter” as an example for convenience of description.", "A blue filter 10b designates a transparent body that is filled in the first region PX1, a green filter 10g designates the first layer formed in the second region PX2, a green barrier layer 20g designates the second layer formed in the second region PX2, a red filter 10r designates the first layer formed in the third region PX3, and a red barrier layer 20r designates the second layer formed in the third region PX3.The first region PX1 includes the blue filter 10b.", "The blue filter 10b may be formed of the transparent body and the quantum dots are not included therein.", "The blue filter 10b thus displays the blue light that is incident light by emitting the blue light.", "The transparent bodies may fill the first region PX1 as shown in FIG.", "2, but may have various heights, sizes, or the like depending on exemplary embodiments.", "The transparent bodies may include scattering-induced particles that change a projecting direction of the blue light, while maintaining a wavelength thereof as unchanged.", "Alternatively, the transparent bodies may be omitted depending on exemplary embodiments.", "In this case, a hollow space may be formed in the first region PX1, and the hollow space may serve as the blue filter 10b.", "Meanwhile, the second layer 20 may not be formed in the first region PX1.This is because, in the case of the exemplarily described blue-light color filter, it is difficult to expect a light-recycling effect by the action of the second layer 20.However, in the case that the color filter 100 of the present exemplary embodiment is a white filter of an ultraviolet filter, the first layer 10b including the quantum dots which radiate the blue light and the second layer for minimizing the luminous efficiency deterioration of the first layer may be formed in the first region PX1 instead of the aforementioned transparent bodies.", "The second region PX2 includes the green filter 10g and the green barrier layer 20g.", "The green filter 10g includes first quantum dots 11a that radiate the green light when the energy states of the quantum dots 11a are excited by receiving blue incident light and return to the ground state.", "Since some of the radiated green light is reflected by the green barrier layer 20g, a projecting passing direction of the radiated green light is changed so that the reflected light is radiated outside the green filter 10g, and thus the reflected light displays a green color.", "Accordingly, the luminous efficiency deterioration of the green light displayed in the second region PX2 may be minimized.", "The third region PX3 includes the red filter 10r and the red barrier layer 20r.", "The red filter 10r includes second quantum dots 11b that radiate the red light when the energy states of the second quantum dots 11b are excited by receiving the blue incident light and return to the ground state.", "Since some of the radiated red light is reflected by the red barrier layer 20r, a projecting passing direction of the radiated red light is changed so that the reflected light is radiated outside the red filter 10r, and thus the reflected light displays a red color.", "Accordingly, the luminous efficiency deterioration of the red light displayed in the third region PX3 may be minimized.", "Meanwhile, the first quantum dots 11a and the second quantum dots 11b are formed of the same material, while having different sizes from each other in order to radiate lights having different wavelengths, e.g., the green light and the red light.", "For example, the first quantum dots 11a may have a smaller size (e.g.", "diameter) than those of the second quantum dots 11b in order to radiate green light of a relatively high energy.", "For example, the first quantum dots 11a may have a center wavelength of about 530±10 nm and a FWHM of about 40˜60 nm.", "In comparison, the second quantum dots 11b may have a larger size than those of the first quantum dots 11a in order to radiate red light having a relatively low energy.", "For example, the second quantum dots may have a center wavelength of about 625±10 nm and a FWHM of about 40˜60 nm.", "Meanwhile, in the present exemplary embodiment, the blue light is converted into the green light or the red light by the action of the first quantum dots 11a or the second quantum dots 11b.", "Further, the converted light is scattered by the light diffusing agents 12 and the scattering-induced particles to be externally radiated from the color filter 100.Accordingly, the light is widely externally radiated and has a uniform light gradation regardless of a position of a viewer.", "Accordingly, the color filter 100 having a wide viewing angle may be provided.", "As described above, the color filter 100 according to the exemplary embodiment may minimize the luminous efficiency deterioration of the first layer 10 that serves as the light emitting layer and the filter, by including the second layer 20 that serves as the optical barrier layer.", "Hereinafter, a display device including the color filter in FIG.", "2 will be described with reference to FIG.", "3.In an exemplary embodiment, a liquid crystal display device is described as an example of the display device including the color filter, but the range of the exemplary embodiment is not limited thereto, and the color filter may be employed in various display devices such as an organic light emitting diode display, a light emitting diode display, or the like.", "FIG.", "3 illustrates a display device including the color filter of FIG.", "2.Referring to FIG.", "3, a display device 1000 according to the present exemplary embodiment includes a light source 200, a lower display panel 300, and an upper display panel 400.The light source 200 may supply first light to the lower display panel 300 and the upper display panel 400 in a first direction D1 of FIG.", "3.The light source 200 may include an emitting body that emits the first light.", "For example, the first light emitted by the light source 200 may have a visible wavelength range, and may be light having high energy in the visible wavelength range, e.g., blue light.", "As such, the blue light, which is the first light, may be supplied to the lower display panel 300 and the upper display panel 400.However, the first light is not limited thereto, and may be any light other than the blue light in the visible wavelength range, or alternatively, may be ultraviolet light in an ultraviolet wavelength range.", "The light source 200 may include an emitting portion (not shown) that includes an emitting body and a light guiding plate that guides the emitted blue light toward the lower display panel 300.The emitting portion may be disposed at one side of the light guiding plate or may be disposed below a lower surface of the light guiding plate.", "The lower display panel 300 may include a first substrate 301 formed of transparent glass, plastic, or the like, and a wiring layer 303 formed on the first substrate 301.The wiring layer 303 may include a thin film transistor (not shown) including a gate line, a storage voltage line, a gate insulating layer, a data line, a source electrode, a drain electrode, a semiconductor, a passivation film, and the like, and the thin film transistor thereof is connected to the gate line and the data line.", "Meanwhile, a pixel electrode 304 is formed on the wiring layer 303.The gate line, the data line, the source electrode, the drain electrode, the semiconductor, and the pixel electrode may have various structures depending on exemplary embodiments.", "The gate line and the storage voltage line are electrically separated from each other, and the data line is insulated from and intersects the gate line and the storage voltage line.", "The gate electrode, the source electrode, and the drain electrode respectively serve as a control terminal, an input terminal, and an output terminal of the thin film transistor.", "The drain electrode is electrically connected to the pixel electrode 304.The pixel electrode 304 may be formed of a transparent conductive material such as indium tin oxide (ITO) or indium zinc oxide (IZO), and may control an alignment direction of liquid crystal molecules by generating an electric field.", "An alignment layer 501 is disposed on the pixel electrode 304.The alignment layer 501 is a liquid crystal alignment layer including polyamic acid, polysiloxane, polyimide, or the like, and may include at least one of generally-used materials.", "The liquid crystal molecules in a liquid crystal layer 500 may be initially aligned by the alignment layer 501.The alignment layer 501 may be variously disposed depending on exemplary embodiments.", "The alignment layer 501 may be disposed at an upper side or a lower side of the liquid crystal layer 500, or may be disposed at both of the upper side and the lower side of the liquid crystal layer 500 as shown in FIG.", "3.In some cases, the alignment layer 501 may be omitted.", "The liquid crystal layer 500 is formed between the lower display panel 300 and the upper display panel 400.The thickness of the liquid crystal layer 500 may be in a range of, e.g., about 5 to 6 μm.", "The types of the liquid crystal molecules in the liquid crystal layer 500 and an operation of the liquid crystal layer 500 may vary depending on exemplary embodiments.", "Specifically, the liquid crystal layer 500 may be interposed between the first substrate 301 and the color filter 100 as shown in FIG.", "3, or may be interposed between a second substrate 401 and the color filter 100, depending on the operation thereof.", "A first polarizing plate 302 is attached on a rear surface of the first substrate 301.The first polarizing plate 302 may include a polarizing element (not shown) and a passivation layer (not shown), and the passivation layer may include tri-acetyl-cellulose (TAC).", "Alternatively, the first polarizing plate 302 may be interposed between the first substrate 301 and the wiring layer 303 or may be disposed at another position in the lower display panel 300.A common electrode 404 is disposed on the liquid crystal layer 500.The common electrode 404 may be formed of the transparent conductive material such as indium tin oxide (ITO) or indium zinc oxide (IZO), and may control the alignment direction of the liquid crystal molecules by generating the electric field.", "However, the common electrode 404 may be disposed variously depending on exemplary embodiments, or may be disposed in the lower display panel 300.The upper display panel 400 may include the second substrate 401 formed of transparent glass, plastic, or the like, and a second polarizing plate 402 disposed thereon.", "The second polarizing plate 402 may include the polarizing element and the passivation layer, and the passivation layer may include tri-acetyl-cellulose (TAC).", "In the present exemplary embodiment, the second polarizing plate 402 is disposed on the second substrate 401, but may be disposed at another position in the upper display panel 400, for example, on the common electrode 404 or under the second substrate 401.In some cases, the second polarizing plate 402 may be omitted.", "The aforementioned color filter 100 is disposed under the second substrate 401, and the color filter 100 is divided into the first region PX1, the second region PX2, and the third region PX3 by the light blocking members 403 as described above.", "The light blocking members 403 may be formed of a light blocking material including, e.g., metal particles of chromium (Cr), silver (Ag), molybdenum (Mo), nickel (Ni), titanium (Ti), tantalum (Ta), or the like, an oxide of the metal particles, or a combination thereof.", "The light blocking members 403 prevent light leakage from the display device 1000 and improve the contrast thereof.", "The light blocking members 403 are disposed under the second substrate 401, and are spaced apart from each other by a predetermined distance therebetween as shown in FIG.", "3.In the present exemplary embodiment, since the color filter 100 is thoroughly divided into each region by the light blocking members 403, the light introduced into one region is prevented from intruding into another region, thereby preventing color mixture between the red, green, and blue lights displayed by the display device 1000.Meanwhile, the color filter 100 is disposed in front of the first substrate 301.Specifically, the first substrate 301, the color filter 100, and the second substrate 401 are sequentially disposed in front of the light source in the first direction D1 that is a supply direction of the first light.", "In the present exemplary embodiment, the color filter 100 may be disposed in the upper display panel 400, but it is not limited thereto.", "For example, the color filter 100 may be disposed in the lower display panel 300 depending upon an operation type of the display device 1000.Herein, based on the first direction D1, the first layer 10 (e.g.", "10b, 10g, 10r) is disposed in front of the second layer 20 (e.g.", "20g, 20r) in the color filter 100.In other words, as shown in FIG.", "3, the color filter 100 has a structure in which the first light is introduced into the green filter 10g or the red filter 10r, which are the first layer, through the green barrier layer 20g or the red barrier layer 20r, which are the second layer.", "As such, it is possible to provide the display device 1000 which can minimize the luminous efficiency deterioration of the first layer 10 caused by the isotropic radiation characteristic of the quantum dots by adjusting a disposition direction of the color filter 100 such that the first light is introduced into the first layer 10 through the second layer 20.Meanwhile, in a manufacturing process of the color filter 100 formed of the photosensitive material, the deterioration of the luminous efficiency of the quantum dots has been reported to occur in each of the photolithographic processes such as exposure, development, baking, and the like.", "However, in the case of the color filter 100 of the aforementioned exemplary embodiment, it is possible to manufacture a color filter capable of minimizing luminous efficiency deterioration in the photolithographic processes by forming a stacked body in which the second layer 20 that serves as the optical barrier layer is disposed on the first layer 10 that serves as a filter layer in the photolithographic processes.", "Hereinafter, a method of manufacturing a color filter that minimizes luminous efficiency deterioration in a manufacturing process according to an exemplary embodiment will be described.", "FIG.", "4 is a flowchart showing the manufacturing method of the color filter of FIG.", "2.Referring to FIG.", "4, the manufacturing method of the color filter according to the exemplary embodiment includes forming a light emitting layer (e.g.", "first layer) on a substrate (S01), forming a barrier layer (e.g.", "second layer) on the first layer to obtain a stacked body in which the first layer and the second layer are stacked on the substrate (S02), pre-baking the stacked body (S03), exposing and developing (e.g.", "patterning) the stacked body to obtain the patterned stacked body (S04), post-baking the patterned stacked body (S05), and aging the stacked body (S06).", "First, preliminary preparation includes preparing the substrate in which a light blocking member is formed, preparing a photosensitive resin for forming the first layer, and preparing a photosensitive resin for forming the second layer.", "In the preparing of the substrate in which the light blocking member is formed, light blocking members are disposed on the substrate formed of glass, plastic, or the like, and are spaced apart from each other at a predetermined distance therebetween.", "The light blocking member is formed of materials including metal particles of chromium (Cr), silver (Ag), molybdenum (Mo), nickel (Ni), titanium (Ti), tantalum (Ta), or the like, oxides of the metal particles, or combinations thereof.", "Separate spaces formed by the light blocking members serve as a first region to a third region.", "In the preparing of the photosensitive resin for forming the first layer, a quantum dot-binder dispersed solution is prepared by mixing a binder and a chloroform dispersed solution of quantum dots (red or green) including a hydrophobic organic ligand at surfaces thereof.", "Herein, the quantum dots are uniformly dispersed in the quantum dot-binder dispersed solution.", "Then, the photosensitive resin for forming the first layer is manufactured by mixing the prepared quantum dot-binder dispersed solution, a photopolymerization monomer, a photoinitiator, a light diffusing agent, a solvent, additives, and the like.", "The photosensitive resin for forming the second layer is manufactured by mixing a photopolymerization monomer, a photoinitiator, a sensitizer, a light diffusing agent, a solvent, additives, and the like.", "In step S01, the forming of the first layer, the photosensitive resin for forming the first layer is spin-coated onto the substrate on which the light blocking member is formed.", "An amount of the region filled with the photosensitive resin for forming the first layer may vary depending on the operation of the display device, and the first region to the third region may be partially filled therewith.", "In step S02, the forming of the second layer, the photosensitive resin for forming the second layer is spin-coated on the first layer.", "Accordingly, a stacked body including a double layer on the substrate, in which the first layer and the second layer are sequentially stacked, may be obtained.", "In the pre-baking (S03), moisture existing in the first layer and the second layer is removed by pre-baking (PRB) the obtained stacked body.", "Specific conditions of the pre-baking such as temperature, time, atmosphere, and the like are already known and may be appropriately adjusted.", "In some cases, the pre-baking may be omitted.", "Through the pre-baking, a dispersed state of the quantum dots and the light diffusing agent in the stacked body from which the moisture is removed may be changed.", "In the exposing and developing (S04), the stacked body after being completely pre-baked is exposed to light having a predetermined wavelength using a mask including a predetermined pattern.", "The wavelength and intensity of the employed light may be adjusted in consideration of type and content of the photoinitiator and the quantum dots.", "Then, the exposed portions of the stacked body are developed using an organic solvent, an alkali solution, or the like.", "Following complete exposure and development of the exposed portions of the stacked body, the unexposed portion of the stacked body is dissolved, and the patterned stacked body in which the first layer and the second layer are stacked in a desired region may be obtained.", "However, the luminous efficiency of the first layer is slightly deteriorated in comparison with the luminous efficiency of the first layer prior to the exposure and development, because a dispersed state of the quantum dots or the light diffusing agent in the first layer may be altered during the exposure and development, or alternatively, loss of the quantum dots or the light diffusing agent may occur during the exposure and development process.", "In the post-baking (S05), the patterned stacked body may be post-baked (POB) to improve crack resistance and solvent resistance.", "The post-baking may be conducted at a temperature of, e.g., about 150° C. to about 230° C. for a predetermined time, e.g., about 10 min or more, or about 20 min or more.", "As the post-baking is performed, physical and chemical characteristics of the first layer may be improved.", "However, the loss of the quantum dots and the light diffusing agent in the first layer may occur since heat is continuously applied thereto, so the luminous efficiency of the first layer may be slightly deteriorated.", "In the aging (S06), the stacked body after being post-baked is continuously exposed to light having a weak intensity and a predetermined wavelength in order to stabilize an optical property of the stacked body.", "The specific conditions of the aging such as wavelength, intensity, exposure time, and the like may be appropriately adjusted.", "In some cases, the aging step may be omitted.", "The aging serves to improve the optical property of the stacked body, so the luminous efficiency of the first layer is slightly improved by the aging.", "When the steps of S01 (the forming of the first layer) to S06 (the aging) are referred to as a unit process, the unit process may be repeatedly performed until all of the first region to the third region are filled by using a step which determines whether all of the first region to the third region of the aforementioned color filter are filled or not (S07).", "If all of the first region to the third region have been filled, the unit processes have been completed.", "If not all of the first region to the third region have been filled, the unit process is repeated.", "However, in the present exemplary embodiment, a number of repeats of the unit process may vary depending on the kinds of the color filter and the operation of the display device.", "For example, in the case that the color filter 100 illustrated in FIG.", "2 is manufactured, since the first region PX1 thereof is filled with the transparent body, one of the second region PX2 and the third region PX3 may be formed, and then the other region may be formed by repeating the unit process a single time.", "The color filter manufactured by the above-described steps may minimize the luminous efficiency deterioration during the processes.", "This is because all of the processes are performed after forming the second layer 20, which serves as a passivation layer on the first layer 10 that serves as a light emitting layer, thereby physically and chemically protecting the first layer 10 from heat during the pre-baking or the post-baking steps, and from the solvent in the exposing and developing steps, or the like.", "Hereinafter, specific examples of the described technology will be disclosed.", "However, the following examples are merely to exemplarily describe the described technology, so the range of the described technology is not limited thereto.", "EXAMPLES Example 1 [1] Preparing Quantum Dot-Binder Dispersed Solution A quantum dot-binder dispersed solution is prepared by mixing chloroform in a dispersed solution including about 50 grams (g) of green quantum dots including oleic acid as a hydrophobic organic ligand at surfaces thereof, and about 100 g of a solution of a binder (propylene glycol monomethyl ether acetate, PGMEA at a concentration of about 30 weight percent (wt %)).", "[2] Preparing Photosensitive Composition for Forming First Layer A photosensitive composition for forming a first layer is prepared by mixing the quantum dot-binder dispersed solution prepared in step [1], about 100 g of hexaacrylate as a photopolymerization monomer, about 1 g of an oxime ester compound as a photoinitiator, about 30 g of TiO2 as a light diffusing agent, about 10 g of pentaerythritol tetra(3-mercaptopropionate) as a curing agent, and about 300 g of PGMEA as a solvent.", "[3] Preparing Photosensitive Composition for Forming Second Layer The photosensitive composition for forming a second layer is prepared by mixing about 100 g of hexaacrylate as a photopolymerization monomer, about 1 g of an oxime ester compound as a photoinitiator, about 10 g of pentaerythritol tetra(3-mercaptopropionate) as a curing agent, and about 300 g of PGMEA as a solvent.", "[4] Manufacturing Color Filter The photosensitive composition for forming the first layer prepared in step [2] is spin-coated on a glass substrate, and then the photosensitive composition for forming the second layer prepared in step [3] is spin-coated on the first layer.", "Accordingly, a stacked film is obtained, in which the substrate, the first layer, and the second layer are sequentially stacked.", "The obtained stacked film is pre-baked at about 100° C. The pre-baked stacked film is exposed to light (wavelength: about 365 nm and intensity: about 100 mW) for about 1 second (s), using a mask having a predetermined pattern, and then is developed using a potassium hydroxide aqueous solution (concentration: about 0.043%) for about 50 s to obtain a pattern thereon.", "The stacked film on which the pattern is formed is post-baked three times, i.e., first, second, and third post-baking, at about 180° C. at about 30 min time intervals.", "The stacked film after the third post-baking is aged by exposing it to light (wavelength: about 450 nm, intensity: about 10 miliwatts (mW)) for 24 hours (h).", "At a time point at which each step is completed, a blue light conversion rate and a blue light absorption rate of the stacked film are measured, and the measured results are listed in Table 1.In this example, the blue light conversion rate designates an amount of light converted to green light with respect to the amount of light radiated to a stack, and the blue light absorption rate designates an amount of light remaining at the first layer or the second layer without returning toward a light source with respect to the amount of light radiated to the stacked body.", "The blue light conversion rate and the blue light absorption rate are represented by an amount of light measured by a photometer (manufactured by Minolta Inc.) for a period of about 1 min.", "Example 2 By executing identical steps [1] to [3] of Example 1, a photosensitive composition for forming a first layer and a photosensitive composition for forming a second layer are formed, and then the photosensitive composition for forming the first layer manufactured in the same manner as described in step [2] of Example 1 is spin-coated on a glass substrate, and the photosensitive composition for forming the second layer manufactured as described in step [3] of Example 1 is spin-coated on the first layer.", "Accordingly, a stacked film is obtained, in which the substrate, the first layer, and the second layer are sequentially stacked.", "The obtained stacked film is pre-baked at about 100° C. The pre-baked stacked film is exposed to light (wavelength: about 365 nm and intensity: about 100 mW) for about 1 s using a mask having a predetermined pattern, and then is developed using a potassium hydroxide aqueous solution (concentration: about 0.043%) for about 50 s to obtain a pattern thereon.", "Then, omitting the post-baking step, the stacked film on which the pattern is formed is directly aged by exposing it to light (wavelength: about 450 nm, intensity: about 10 mW) for 24 h. After each of the above steps is completed, the blue light conversion rate and the blue light absorption rate of the film are measured, and the measured results are listed in Table 2.Comparative Example By executing identical steps as described in steps [1] and [2] of Example 1, a photosensitive composition for forming a first layer is prepared, and then the photosensitive composition for forming the first layer prepared as described in step [2] of Example 1 is spin-coated on a glass substrate.", "Accordingly, a monolayer film is obtained, in which the first layer as a monolayer is stacked on the substrate.", "The obtained monolayer film is pre-baked, patterned (i.e.", "exposed and developed), and first, second, and third post-baked under identical conditions to those described in Example 1.Then, the blue light conversion rate and the blue light absorption rate of the monolayer film are measured after each step is completed, and the measured results are listed in Table 1.Table 1 is as follows.", "TABLE 1 Comparative Example 1 Example Pre-baking (PRB) Blue light 30 29 conversion rate (%) Blue light 82 74 absorption rate (%) Exposure and Blue light 28 26 development conversion rate (%) (EXP & DEV) Blue light 81 74 absorption rate (%) First post-baking Blue light 24 19 (POB1) conversion rate (%) Blue light 82 75 absorption rate (%) Second post-baking Blue light 21 17 (POB2) conversion rate (%) Blue light 83 75 absorption rate (%) Third post-baking Blue light 22 15 POB3 conversion rate (%) Blue light 83 76 absorption rate (%) Aging (AGN) Blue light 26 ND conversion rate (%) Blue light 82 absorption rate (%) POB1/PRB 80 65 POB2/PRB 70 58 POB3/PRB 73 51 AGN/PRB 86 ND In Table 1, in the case of the monolayer film of the Comparative Example, an additional process such as further forming a passivation layer or the like is needed to perform the aging step, so the aging is not performed in the comparative example.", "Accordingly, items related to the aging in the comparative example are listed as ND (“No Data”).", "Further, in Table 1, the post-baking step in which a light conversion rate is most severely deteriorated, is performed continuously three times instead of repeatedly performing the pre-baking, the exposing and developing, the post-baking, and the aging.", "As such, it is possible to simulate a thermal environment that may be applied to a filter firstly formed on the substrate when a filter is formed in each of the first region to the third region.", "Referring to Table 1, in the case of the pre-baking as an initial step, blue light conversion rates are the same in Example 1 and the Comparative Example, but the blue light absorption rate of Example 1 are about an 8% higher value than that of the Comparative Example.", "This means that, in the case of the Comparative Example, the luminous efficiency is deteriorated by evaporating the moisture or the like in the first layer, which is the monolayer, in the pre-baking step.", "The blue light conversion rates of Example 1 and the Comparative Example are deteriorated by a chemical environment where the exposure and the development are performed, but the blue light conversion rate of Example 1 shows slower deterioration than that of the Comparative Example.", "The blue light conversion rate of the Comparative Example is gradually decreased by about 7%, about 2%, and about 1% in the first to third post-baking steps, respectively.", "In total, the Comparative Example generally shows a total luminous efficiency deterioration of about 10%.", "In contrast, the blue light conversion rate of Example 1 is decreased by about 4% in the first post-baking step and about 3% in the second post-baking step, but is increased by about 1% in the third post-baking step.", "In total, Example 1 generally shows a total luminous efficiency deterioration of about 6%.", "Based on the results of Table 1, when the light conversion rate of the stacked body being post-baked with respect to that of the stacked body being pre-baked is referred to as first retention, it can be seen that the first retention of Example 1 may be in a range of about 70% to about 100%.", "In contrast, in the case of being formed as the monolayer in the Comparative Example, it can be seen that the first retention may be a maximum of about 65% or less.", "Therefore, it can be seen that the stacked structure of Example 1, in which the second layer is further disposed on the first layer, may effectively prevent the luminous efficiency deterioration caused by heat.", "Meanwhile, in the case of Example 1, an optical characteristic of the first layer may be improved by the aging.", "Accordingly, it can be seen that the luminous efficiency after the aging step is increased by about 4% in comparison with that after the third post-baking step.", "Further, when the light conversion rate of the aged stacked body with respect to that of the pre-baked stacked body is referred to as second retention, it can be seen that the second retention of Example 1 may be in a range of about 85% to about 100%.", "In contrast, in the case of being formed as the monolayer in the Comparative Example, the additional step for forming the passivation layer or the like after the post-baking step is required to perform the aging, and a total number of steps is increased, which may be undesirable in consideration of manufacturing efficiency.", "Table 2 is as follows.", "TABLE 2 Example 2 Pre-baking (PRB) Blue light 31 conversion rate (%) Blue light 78 absorption rate (%) Exposure and Blue light 31 development conversion rate (%) (EXP & DEV) Blue light 78 absorption rate (%) Aging (AGN) Blue light 36 conversion rate (%) Blue light 78 absorption rate (%) AGN/PRB 86 Referring to Table 2, for Example 2, in which the stacked body is subjected to the aging step after the patterning step without being subjected to the post-baking step, an excellent blue light conversion rate is shown.", "For example, when the light conversion rate of the aged stacked body with respect to that of the post-baked stacked body is referred to as third retention, the third retention may be in a range of about 100% to about 120%.", "Therefore, it can be seen that the luminous efficiency of Example 2 may be improved similarly to that of Example 1 even though the aging step is directly performed without the post-baking step.", "As described above, the luminous efficiency deterioration during the manufacturing process may be minimized when the color filter according to the exemplary embodiment is manufactured by performing the photolithographic patterning process after forming the stacked body including the second layer which serves as the optical barrier layer disposed on the first layer which serves as the light emitting layer.", "Moreover, the display device including the color filter as well as the color filter may be expected to show an improvement in luminous efficiency of the first layer due to the light-recycling caused by the second layer.", "Consequently, according to the exemplary embodiment, it is possible to provide a color filter and a display device including the color filter that may minimize the luminous efficiency deterioration which occurs during the manufacturing process and maintain the excellent luminous efficiency after the manufacturing process.", "While this disclosure has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims." ] ]
Patent_15872595
[ [ "VIEWING SUGGESTIONS BASED ON CLOSED-CAPTIONED CONTENT FROM MULTIPLE TUNERS", "Described are systems, methods and computer program products for suggesting television programs to a user by, for example, analyzing closed caption or subtitle content of unwatched or unrecorded video content to determine if the video content is of interest to the user.", "The user may indicate one or more keywords for use in the analysis and the analysis may scan the text of the closed caption or subtitle content to identify matches to the keywords.", "Beside user input keywords, the keywords may also be determined through analysis of video content watched or recorded by the user to determine frequently encountered words.", "These frequently encountered words may automatically be used in matching the text of the closed caption or subtitle content.", "The users may also or alternatively select particular words of the frequently encountered words to use for matching." ], [ "1.A television receiver, comprising: one or more processors; a plurality of tuners communicatively coupled with the one or more processors; an audio-video output interface communicatively coupled with the one or more processors; and a non-transitory computer readable storage medium communicatively coupled with and readable by the one or more processors and having stored therein processor-readable instructions that, when executed by the one or more processors, cause the one or more processors to perform operations including: receiving input corresponding to determination of one or more user-designated keywords; receiving first program content using an active tuner of the plurality of tuners; outputting the first program content using the audio-video output interface for display on a display device; receiving second program content using an inactive tuner of the plurality of tuners; obtaining text data corresponding to an audio portion of the second program content; determining that a first keyword of the one or more user-designated keywords appears in the text data; and generating a first interface for output by the audio-video output interface for display on the display device in real-time upon determining that the first keyword appears in the text data, wherein the first interface includes a notification identifying a match of the first keyword.", "2.The television receiver of claim 1, wherein the inactive tuner corresponds to a tuner of the plurality of tuners that is not being actively used to output live program content for display on the display device or to record program content according to a recording schedule or timer.", "3.The television receiver of claim 1, wherein obtaining the text data includes one or more of: decoding a closed caption portion of the second program content to generate the text data, decoding a subtitle portion of the second program content to generate the text data, retrieving the text data from a network location, processing the audio portion of the second program content using a speech-to-text algorithm to generate the text data, or rendering embedded closed captions or subtitles of the second program content and generating the text data by performing character recognition on the embedded closed captions or subtitles.", "4.The television receiver of claim 1, wherein the input corresponds to user entry of the one or more user-designated keywords or to user selection of one or more user-designated keywords from a word list.", "5.The television receiver of claim 1, wherein the operations further comprise: automatically determining one or more additional keywords without user input; determining that a second keyword of the one or more additional keywords appears in the text data; and generating a second interface for output by the audio-video output interface for display on the display device in real-time upon determining that the second keyword appears in the text data, wherein the second interface identifies the second keyword and the second program content.", "6.The television receiver of claim 5, wherein automatically determining the one or more additional keywords without user input includes: monitoring recorded or watched text data corresponding to audio portions of at least one of program content recorded by the television receiver and program content output by the audio-video output interface for immediate display on the display device; evaluating the recorded or watched text data to rank words appearing in the watched or recorded text data by frequency; and adding one or more words appearing in the recorded or watched text data having rankings greater than a threshold ranking to a word list corresponding to the one or more additional keywords.", "7.The television receiver of claim 1, wherein the first interface requests selection of a command, wherein the command corresponds to at least one of: record the second program content, immediately output the second program content for display on the display device, or ignore the second program content.", "8.The television receiver of claim 1, wherein the first interface corresponds to a notification overlaid on a graphical user interface, an electronic programming guide, or other program content being output by the audio-video output interface for display on the display device.", "9.The television receiver of claim 1, further comprising: receiving second program content using a second inactive tuner of the plurality of tuners; obtaining second text data corresponding to audio of the second program content; determining that a second keyword of the one or more user-designated keywords appears in the second text data; and generating a second interface for output by the audio-video output interface for display on the display device in real-time upon determining that the second keyword appears in the second text data, wherein the second interface identifies the second keyword and the second program content.", "10.A method, comprising: receiving, by a television receiver, input corresponding to determination of one or more user-designated keywords; receiving, by the television receiver, first program content using an active tuner of the television receiver; outputting, by the television receiver, the first program content for display by a display device; receiving, by the television receiver, second program content using an inactive tuner of the television receiver; obtaining, by the television receiver, text data corresponding to an audio portion of the second program content; determining, by the television receiver, that a first keyword of the one or more user-designated keywords appears in the text data; and generating, by the television receiver, a first interface for display on the display device in real-time upon determining that the first keyword appears in the text data, wherein the first interface includes a notification identifying a match of the first keyword.", "11.The method of claim 10, wherein obtaining the text data includes one or more of: decoding a closed caption portion of the second program content to generate the text data, decoding a subtitle portion of the second program content to generate the text data, retrieving the text data from a network location, processing the audio portion of the second program content using a speech-to-text algorithm to generate the text data, or rendering embedded closed captions or subtitles of the second program content and generating the text data by performing character recognition on the embedded closed captions or subtitles.", "12.The method of claim 10, further comprising automatically determining one or more additional keywords without user input; determining that a second keyword of the one or more additional keywords appears in the text data; and generating a second interface for display on the display device in real-time upon determining that the second keyword appears in the text data, wherein the second interface identifies the second keyword and the second program content.", "13.The method of claim 12, wherein automatically determining the one or more additional keywords without user input includes: monitoring recorded or watched text data corresponding to audio portions of at least one of program content recorded by the television receiver and program content output by the television receiver for immediate display on the display device; evaluating the recorded or watched text data to rank words appearing in the watched or recorded text data by frequency; and adding one or more words appearing in the recorded or watched text data having rankings greater than a threshold ranking to a word list corresponding to the one or more additional keywords.", "14.The method of claim 10, wherein the first interface requests selection of a command, wherein the command corresponds to at least one of: record the second program content, immediately output the second program content for display on the display device, or ignore the second program content.", "15.The method of claim 10, further comprising: receiving, by the television receiver, second program content using a second inactive tuner of the television receiver; obtaining, by the television receiver, second text data corresponding to audio of the second program content; determining, by the television receiver, that a second keyword of the one or more user-designated keywords appears in the second text data; and generating, by the television receiver, a second interface for display on the display device in real-time upon determining that the second keyword appears in the second text data, wherein the second interface identifies the second keyword and the second program content.", "16.A non-transitory computer readable storage medium comprising instructions that, when executed by one or more processors, cause the one or more processors to perform operations including: receiving input corresponding to determination of one or more user-designated keywords; receiving first program content using an active tuner; outputting the first program content for display by a display device; receiving second program content using an inactive tuner; obtaining text data corresponding to an audio portion of the second program content; determining that a first keyword of the one or more user-designated keywords appears in the text data; and generating a first interface for display on the display device in real-time upon determining that the first keyword appears in the text data, wherein the first interface includes a notification identifying a match of the first keyword.", "17.The non-transitory computer readable storage medium of claim 16, wherein obtaining the text data includes one or more of: decoding a closed caption portion of the second program content to generate the text data, decoding a subtitle portion of the second program content to generate the text data, retrieving the text data from a network location, processing the audio portion of the second program content using a speech-to-text algorithm to generate the text data, or rendering embedded closed captions or subtitles of the second program content and generating the text data by performing character recognition on the embedded closed captions or subtitles.", "18.The non-transitory computer readable storage medium of claim 16, wherein the operations further include: automatically determining one or more additional keywords without user input; determining that a second keyword of the one or more additional keywords appears in the text data; and generating a second interface for display on the display device in real-time upon determining that the second keyword appears in the text data, wherein the second interface identifies the second keyword and the second program content.", "19.The non-transitory computer readable storage medium of claim 18, wherein automatically determining the one or more additional keywords without user input includes: monitoring recorded or watched text data corresponding to audio portions of at least one of program content being instantly recorded and program content output for immediate display on the display device; evaluating the recorded or watched text data to rank words appearing in the watched or recorded text data by frequency; and adding one or more words appearing in the recorded or watched text data having rankings greater than a threshold ranking to a word list corresponding to the one or more additional keywords.", "20.The non-transitory computer readable storage medium of claim 16, wherein the operations further include: receiving second program content using a second inactive tuner; obtaining second text data corresponding to audio of the second program content; determining that a second keyword of the one or more user-designated keywords appears in the second text data; and generating a second interface for display on the display device in real-time upon determining that the second keyword appears in the second text data, wherein the second interface identifies the second keyword and the second program content." ], [ "<SOH> BACKGROUND <EOH>Television receivers may automatically suggest and record new programs based on the similarity of the new programs to other programs previously recorded by the user.", "However, the suggested programs may not always be of interest to the user, so alternative suggestion techniques may warrant further exploration." ], [ "<SOH> SUMMARY <EOH>Described herein are systems, methods, and computer program products for providing suggested programming to a user based on closed caption or subtitle data from channels not being watched or recorded by a user.", "The systems, methods and computer program products may use the closed caption or subtitle data from the unwatched channels as a more comprehensive data source than just a program title or synopsis to provide better program suggestions to the user in real-time as the programs are broadcast on the unwatched channels.", "Advantageously, the disclosed systems, methods, and products permit new ways to utilize unused tuners and simultaneously allow users to have program content that may be of interest identified for them.", "As an example, a brief synopsis of a program available in a program guide may not actually describe any of the specific information depicted in the program, such as occurs for most news broadcasts or other programming.", "A user may have interest in seeing a news report on a particular subject, but the synopsis may only indicate that the news program is describing news of the day without a description of any of the specific news reports.", "Using the present invention, a user may be alerted when a subject of interest is depicted and the user may command their television receiver to display or record the news program so that the program can be immediately watched or watched at a later time.", "In a first aspect, methods are provided herein, such as methods for generating suggested programming for a user or viewer.", "An example method of this aspect comprises receiving, such as by a television receiver, video content using an inactive tuner of the television receiver; obtaining text data corresponding to an audio portion of the video content; evaluating or analyzing the text data to identify frequencies of words appearing in the text data; receiving input corresponding to determination of one or more user-designated keywords; storing the one or more user-designated keywords to a word list, such as a word list that includes at least a first keyword; determining, that the first keyword appears in the text data with a first frequency greater than a first threshold frequency; and generating a first interface for display on a display device in real-time upon determining that the first frequency is greater than the first threshold frequency, wherein the first interface includes a notification identifying a match of the first keyword.", "Optionally, the television receiver includes a plurality of tuners.", "It will be appreciated that the terms “inactive tuner,” “idle tuner,” and “unused tuner” may correspond to tuners of a television receiver that are unused for conventional display or recording purposes.", "For example, the inactive tuner may correspond to a tuner of the television receiver that is not being actively used to display live video content on the display device.", "As another example, the inactive tuner may correspond to a tuner of the television receiver that is not being actively used to record video content according to a recording schedule or timer.", "In this way, television receivers including a plurality of tuners may have any number of inactive tuners used for a non-conventional purpose in suggesting programming potentially of interest to a user or viewer.", "Various sources of the text data are contemplated.", "For example, obtaining the text data optionally includes decoding a closed caption portion of the video content to generate the text data.", "Alternatively or additionally, obtaining the text data includes decoding a subtitle portion of the video content to generate the text data.", "Optionally, obtaining the text data includes retrieving the text data from a network location, such as a location on an Internet server.", "Other techniques for obtaining the text data are contemplated.", "For example, obtaining the text data optionally includes processing the audio portion of the video content using a speech-to-text algorithm to generate the text data.", "Optionally, obtaining the text data includes rendering the video content with embedded closed captions or subtitles and generating the text data by performing character recognition on the embedded closed captions or subtitles.", "It will be appreciated that certain methods for generating the text data may be computationally prohibitive for some systems, but these techniques may be viable for specially constructed television receivers, such as with processors specially configured for speech-to-text or optical character recognition, as well as television receivers exhibiting suitable processing resources.", "Optionally, the frequency of words in the text data are determined in order to allow for programming including repeated use of the same words to be identified as such.", "Such analysis allows for more flexible suggestion algorithms to be employed, such as algorithms in which the frequency of words in the text data are used to better identify program suggestions.", "Optionally, evaluating or analyzing the text data includes generating a database including one or more words in the text data and tracking appearances of the one or more words in the text data using the database.", "Optionally, each word is assigned a unique identifier to simplify the database, processing of the text data, and/or matching words in the text data to a keyword.", "Optionally, common words, such as pronouns, conjunctions, prepositions, articles, etc., may be removed or excluded from the analysis in order not to obscure the subject of the programming.", "Optionally, the list of removed or excluded words is user selectable or editable.", "The keywords used for matching may be user determined or suggested for the user.", "For example, the input may optionally correspond to user entry of one or more user-designated keywords.", "Optionally, the input corresponds to selection of one or more user-designated keywords from a word list.", "The word list may be user selectable or editable.", "Optionally, the keywords used for matching may be automatically determined.", "For example, programs watched or recorded by the user may have their text data scanned and analyzed to determine commonly used words and some of these words, such as the most common words, may be automatically added to the word list or may be suggested to the user for adding to the word list.", "Optionally, a method of this aspect comprises or further comprises automatically adding one or more keywords to the word list without user input.", "Alternatively or additionally, a method of this aspect comprises or further comprises generating the word list by monitoring recorded or watched text data corresponding to audio portions of at least one of video content recorded by the television receiver and video content output by the television receiver for immediate display on the display device; evaluating the recorded or watched text data to rank words appearing in the watched or recorded text data by frequency; and adding one or more words appearing in the recorded or watched text data having rankings greater than a threshold ranking to the word list.", "Optionally, common words, such as pronouns, conjunctions, prepositions, articles, etc., may be removed from the analysis or When words appearing in the text data match words in the word list, it may be desirable to ensure that the matched word appears in the text data multiple times before suggesting the programming to a user or viewer.", "This may eliminate or reduce false positive detections or suggested programming that is not of interest to the user.", "Optionally, the first threshold frequency is user selectable.", "For example, the first threshold frequency may correspond to a specific number of appearances or occurrences of keywords in the text data.", "Optionally, the first threshold frequency may correspond to 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 occurrences of a match of words in the text data to keywords in the word list.", "Optionally, the first threshold frequency corresponds to a specific number of appearances or occurrences of keywords in the text data within a specific amount of time, such as N or more occurrences within 10 seconds, N or more occurrences within 30 seconds, N or more occurrences within 60 seconds, N or more occurrences within 5 minutes, or N or more occurrences within 15 minutes, where N represents a threshold number, such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, etc.", "It may also or alternatively be useful to detect matches of more than one word in order to eliminate or reduce false positive detections or suggested programming that is not of interest to the user.", "For example, it may be useful to match words in the text data to 1, 2, 3, 4, or 5 keywords in the word list.", "For example, the word list may optionally include a second keyword and methods of this aspect may comprise or further comprise determining that the second keyword appears in the text data with a second frequency greater than a second threshold frequency.", "Optionally, generating the first interface includes generating the first interface in real-time upon determining that both the first frequency is greater than the first threshold frequency and the second frequency is greater than the second threshold frequency.", "Optionally, the first interface includes a notification identifying a match of the first keyword, the second keyword, or both the first keyword and the second keyword.", "Various algorithms may be used to determine that the first keyword appears in the text data with the first frequency greater than the first threshold frequency.", "For example, determining that the first keyword appears in the text data with the first frequency greater than the first threshold frequency may include comparing words appearing in the text data having frequencies greater than the first threshold frequency with the first keyword to determine the match.", "Alternatively or additionally, determining that the first keyword appears in the text data with the first frequency greater than the first threshold frequency includes searching a database including one or more words in the text data using the first keyword to identify a number or frequency of appearances of the first keyword in the text data; and determining that the number or frequency of appearances of the first keyword in the text data is greater than the first threshold frequency.", "An interactive interface may optionally be generated upon detection of a suitable match between a keyword and words in text data.", "The interactive interface may, for example, correspond to an element of a graphical user interface, an element of an electronic programming guide, or an overlay element provided on top of or alternative to video content being output for display on a display device.", "Optionally, the first interface requests selection of a command.", "Useful commands include, but are not limited to, at least one of a command to record the video content, a command to immediately display the video content, or a command to ignore the video content.", "Optionally, a method of this aspect may comprise or further comprise receiving user input corresponding to determination of a command to record the video content, immediately display the video content, or ignore the video content.", "Optionally, the first interface corresponds to a notification overlayed on a graphical user interface, an electronic programming guide, or other video content being output for display on the display device.", "It will be appreciated that multiple tuners of a television receiver may be used for generating suggested programming in accordance with various aspects of the invention disclosed herein.", "Each tuner may optionally be utilized in identical or similar ways as described above, such as for generating suggested programming, displaying live broadcast content in real-time or with a small delay (such as a delay of between 0 and 30 seconds), or recording broadcast content.", "For example, a method of this aspect may comprise or further comprise receiving second video content using a second tuner of the television receiver; and outputting an output signal corresponding to the second video content for displaying the second video content on a display device.", "Alternatively or additionally, a method of this aspect may comprise or further comprise receiving second video content using a second tuner of the television receiver; and recording the second video content to a local storage medium.", "Alternatively or additionally, a method of this aspect may comprise or further comprise receiving second video content using a second inactive tuner of the television receiver; obtaining second text data corresponding to audio of the second video content; evaluating the second text data to identify second frequencies of words appearing in the second text data; determining that a second keyword appears in the second text data with a second frequency greater than a second threshold frequency; and generating a second user interactive interface for display on a display device in real-time upon determining that the second frequency is greater than the second threshold frequency, such as a second user interactive interface that indicates a second match of the second keyword.", "Optionally, the program suggestion aspects described herein may be activated or deactivated by a user, as desired.", "It will be appreciated that the program suggestion aspects may be referred to herein as a “scanning service,” since the text data of the video content may be scanned in real-time to identify word matches for use in suggesting programming or content to a user or viewer.", "For example, a method of this aspect may comprise or further comprise generating an additional interface that includes an item for activating a scanning service using one or more inactive tuners of the television receiver; and receiving input corresponding to selection of the item for activating the scanning service.", "Alternatively or additionally, a method of this aspect may comprise or further comprise generating an additional interface that includes an item for deactivating a scanning service using one or more inactive tuners of the television receiver; receiving input corresponding to selection of the item for deactivating the scanning service; and stopping the scanning service.", "Optionally, stopping includes one or more of stopping receiving the video content using the inactive tuner of the television receiver; stopping obtaining text data corresponding to the audio portion of the video content; stopping evaluating the text data to identify frequencies of words appearing in the text data; and stopping determining that the first keyword appears in the text data with the first frequency greater than the first threshold frequency.", "In another aspect, systems are provided.", "System of various embodiments provided herein may perform any of the above methods.", "For example, a system of this aspect may comprise one or more processors; a plurality of tuners communicatively coupled with the one or more processors; an audio-video output interface communicatively coupled with the one or more processors; and a non-transitory computer readable storage medium communicatively coupled with and readable by the one or more processors and having stored therein processor-readable instructions that, when executed by the one or more processors, cause the one or more processors to perform operations including: receiving video content using an inactive tuner of the plurality of tuners; obtaining text data corresponding to an audio portion of the video content; evaluating the text data to identify frequencies of words appearing in the text data; receiving input corresponding to determination of one or more user-designated keywords; storing the one or more user-designated keywords to a word list, such as a word list that includes at least a first keyword; determining that the first keyword appears in the text data with a first frequency greater than a first threshold frequency; and generating a first interface for output by the audio-video output interface for displaying on a display device in real-time upon determining that the first frequency is greater than the first threshold frequency, such as a first interface that includes a notification identifying a match of the first keyword.", "Optionally, the inactive tuner corresponds to a tuner of the plurality of tuners that is not being actively used to display live video content on the display device.", "Optionally, the inactive tuner corresponds to a tuner of the television receiver that is not being actively used to record video content according to a recording schedule or timer.", "Optionally, obtaining the text data includes decoding a closed caption portion of the video content to generate the text data.", "Optionally, obtaining the text data includes decoding a subtitle portion of the video content to generate the text data.", "Optionally, obtaining the text data includes retrieving the text data from a network location, such as an Internet server.", "Optionally, obtaining the text data includes processing the audio portion of the video content using a speech-to-text algorithm to generate the text data.", "Optionally, obtaining the text data includes rendering the video content with embedded closed captions or subtitles and generating the text data by performing character recognition on the embedded closed captions or subtitles.", "Optionally, evaluating includes generating a database including one or more words in the text data and tracking appearances of the one or more words in the text data using the database.", "Optionally, the input corresponds to user entry of one or more user-designated keywords.", "Optionally, the input corresponds to selection of one or more user-designated keywords from a word list.", "Optionally, one or more keywords are added to the word list automatically and without user input.", "Optionally, the operations include or further include generating the word list.", "For example, generating the word list optionally includes monitoring recorded or watched text data corresponding to audio portions of at least one of video content recorded by the television receiver and video content output by the television receiver for immediate display on the display device; evaluating the recorded or watched text data to rank words appearing in the watched or recorded text data by frequency; and adding one or more words appearing in the recorded or watched text data having rankings greater than a threshold ranking to the word list.", "Optionally, the first threshold frequency is user selectable.", "Optionally, the word list includes a second keyword.", "Optionally, the operations include or further include determining that the second keyword appears in the text data with a second frequency greater than a second threshold frequency, and generating the first interface includes generating the first interface in real-time upon determining that both the first frequency is greater than the first threshold frequency and the second frequency is greater than the second threshold frequency, such that the first interface includes the notification identifying a match of the first keyword, the second keyword, or both the first keyword and the second keyword.", "Optionally, the first threshold frequency corresponds to a specific number of appearances, as described above with reference to the disclosed methods.", "Optionally, the first threshold frequency corresponds to a specific number of appearances within a specific amount of time, as described above with reference to the disclosed methods.", "Optionally, determining that the first keyword appears in the text data with the first frequency greater than the first threshold frequency includes comparing words appearing in the text data having frequencies greater than the first threshold frequency with the first keyword to determine the match.", "Optionally, determining that the first keyword appears in the text data with the first frequency greater than the first threshold frequency includes searching a database including one or more words in the text data using the first keyword to identify a number or frequency of appearances of the first keyword in the text data; and determining that the number or frequency of appearances of the first keyword in the text data is greater than the first threshold frequency.", "Optionally, the first interface requests selection of a command, wherein the command corresponds to at least one of record the video content, immediately display the video content, or ignore the video content.", "Optionally, the operations include or further include receiving user input corresponding to determination of a command to record the video content, immediately display the video content, or ignore the video content.", "Optionally, the notification is overlayed on a graphical user interface, an electronic programming guide, or other video content being output for display on the display device.", "Optionally, the operations include or further include receiving second video content using a second tuner of the television receiver; and outputting an output signal corresponding to the second video content for displaying the second video content on a display device.", "Optionally, the operations include or further include receiving second video content using a second tuner of the television receiver; and recording the second video content to a local storage medium.", "Optionally, the operations include or further include receiving second video content using a second inactive tuner of the television receiver; obtaining second text data corresponding to audio of the second video content; evaluating the second text data to identify second frequencies of words appearing in the second text data; determining that a second keyword appears in the second text data with a second frequency greater than a second threshold frequency; and generating a second user interactive interface for display on a display device in real-time upon determining that the second frequency is greater than the second threshold frequency, such as a second user interactive interface that indicates a second match of the second keyword.", "Optionally, the operations include or further include generating a second interface that includes an item for activating a scanning service using one or more inactive tuners of the television receiver; and receiving, by the television receiver, input corresponding to selection of the item for activating the scanning service.", "Optionally, the operations include or further include generating, by the television receiver, a second interface that includes an item for deactivating a scanning service using one or more inactive tuners of the television receiver; receiving, by the television receiver, input corresponding to selection of the item for deactivating the scanning service; and stopping, by the television receiver, the scanning service.", "Optionally, stopping includes one or more of stopping receiving the video content using the inactive tuner of the television receiver; stopping obtaining text data corresponding to the audio portion of the video content; stopping evaluating the text data to identify frequencies of words appearing in the text data; and stopping determining that the first keyword appears in the text data with the first frequency greater than the first threshold frequency.", "It will again be appreciated that the systems of this aspect may optionally perform any of the methods described above.", "For example, the instructions stored on the non-transitory computer readable medium, when executed by the one or more processors, may cause the one or more processors to perform any of the methods described above.", "In another aspect, computer program products are provided.", "In some embodiments, a computer program product of this aspect may correspond to a computer program, stored on a non-transitory computer readable storage medium.", "The computer program may correspond to processor executable instructions for performing any of the methods described above.", "The computer program may be suitable for loading on and or execution by a system, such as a television receiver.", "A non-transitory computer readable storage medium of this aspect may comprise instructions that, when executed by one or more processors, cause the one or more processors to perform operations including: receiving video content using an inactive tuner of a television receiver; obtaining text data corresponding to an audio portion of the video content; evaluating the text data to identify frequencies of words appearing in the text data; receiving input corresponding to determination of one or more user-designated keywords; storing the one or more user-designated keywords to a word list, such as a word list that includes at least a first keyword; determining that the first keyword appears in the text data with a first frequency greater than a first threshold frequency; and generating a first interface for display on a display device in real-time upon determining that the first frequency is greater than the first threshold frequency, such as a first interface that includes a notification identifying a match of the first keyword.", "Optionally, the television receiver includes a plurality of tuners, and the inactive tuner corresponds to one of the plurality of tuners.", "Optionally, the inactive tuner corresponds to a tuner of the television receiver that is not being actively used to display live video content on the display device.", "Optionally, the inactive tuner corresponds to a tuner of the television receiver that is not being actively used to record video content according to a recording schedule or timer.", "Optionally, obtaining the text data includes decoding a closed caption portion of the video content to generate the text data.", "Optionally, obtaining the text data includes decoding a subtitle portion of the video content to generate the text data.", "Optionally, obtaining the text data includes retrieving the text data from a network location.", "Optionally, obtaining the text data includes processing the audio portion of the video content using a speech-to-text algorithm to generate the text data.", "Optionally, obtaining the text data includes rendering the video content with embedded closed captions or subtitles and generating the text data by performing character recognition on the embedded closed captions or subtitles.", "Optionally, evaluating includes generating a database including one or more words in the text data and tracking appearances of the one or more words in the text data using the database.", "Optionally, the input corresponds to user entry of one or more user-designated keywords.", "Optionally, the input corresponds to selection of one or more user-designated keywords from a word list.", "Optionally, one or more keywords are automatically added to the word list without user input.", "Optionally, the operations include or further include generating the word list.", "Optionally, generating the word list includes monitoring recorded or watched text data corresponding to audio portions of at least one of video content recorded by the television receiver and video content output by the television receiver for immediate display on the display device; evaluating the recorded or watched text data to rank words appearing in the watched or recorded text data by frequency; and adding one or more words appearing in the recorded or watched text data having rankings greater than a threshold ranking to the word list.", "Optionally, the first threshold frequency is user selectable.", "Optionally, the word list includes a second keyword.", "Optionally, the operations include or further include determining that the second keyword appears in the text data with a second frequency greater than a second threshold frequency.", "Optionally, generating the first interface includes generating the first interface in real-time upon determining that both the first frequency is greater than the first threshold frequency and the second frequency is greater than the second threshold frequency, such as where the first interface includes the notification identifying a match of the first keyword, the second keyword, or both the first keyword and the second keyword.", "Optionally, the first threshold frequency corresponds to a specific number of appearances, such as described above with reference to the disclosed methods.", "Optionally, the first threshold frequency corresponds to a specific number of appearances within a specific amount of time, such as described above with reference to the disclosed methods.", "Optionally, determining that the first keyword appears in the text data with the first frequency greater than the first threshold frequency includes comparing words appearing in the text data having frequencies greater than the first threshold frequency with the first keyword to determine the match.", "Optionally, determining that the first keyword appears in the text data with the first frequency greater than the first threshold frequency includes searching a database including one or more words in the text data using the first keyword to identify a number or frequency of appearances of the first keyword in the text data; and determining that the number or frequency of appearances of the first keyword in the text data is greater than the first threshold frequency.", "Optionally, the first interface requests selection of a command, such as a command that corresponds to at least one of record the video content, immediately display the video content, or ignore the video content.", "Optionally, the operations include or further include: receiving user input corresponding to determination of a command to record the video content, immediately display the video content, or ignore the video content.", "Optionally, the notification is overlayed on a graphical user interface, an electronic programming guide, or other video content being output for display on the display device.", "Optionally, the operations include or further include receiving second video content using a second tuner of the television receiver; and outputting an output signal corresponding to the second video content for displaying the second video content on a display device.", "Optionally, the operations include or further include receiving second video content using a second tuner of the television receiver; and recording the second video content to a local storage medium.", "Optionally, the operations include or further include receiving second video content using a second inactive tuner of the television receiver; obtaining second text data corresponding to audio of the second video content; evaluating the second text data to identify second frequencies of words appearing in the second text data; determining that a second keyword appears in the second text data with a second frequency greater than a second threshold frequency; and generating a second user interactive interface for display on a display device in real-time upon determining that the second frequency is greater than the second threshold frequency, such as a second user interactive interface that indicates a second match of the second keyword.", "Optionally, the operations include or further include generating a second interface that includes an item for activating a scanning service using one or more inactive tuners of the television receiver; and receiving input corresponding to selection of the item for activating the scanning service.", "Optionally, the operations include or further include generating a second interface that includes an item for deactivating a scanning service using one or more inactive tuners of the television receiver; receiving input corresponding to selection of the item for deactivating the scanning service; and stopping the scanning service.", "Optionally, stopping includes one or more of stopping receiving the video content using the inactive tuner of the television receiver; stopping obtaining text data corresponding to the audio portion of the video content; stopping evaluating the text data to identify frequencies of words appearing in the text data; and stopping determining that the first keyword appears in the text data with the first frequency greater than the first threshold frequency.", "Without wishing to be bound by any particular theory, there can be discussion herein of beliefs or understandings of underlying principles relating to the invention.", "It is recognized that regardless of the ultimate correctness of any mechanistic explanation or hypothesis, an embodiment of the invention can nonetheless be operative and useful." ], [ "CROSS-REFERENCES TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "15/408,060, filed on Jan. 17, 2017, which claims the benefit of and priority to U.S.", "Provisional Patent Application No.", "62/440,621, filed on Dec. 30, 2016.These applications are hereby incorporated by reference in their entireties for all purposes.", "FIELD This application relates generally to suggesting television programs to viewers.", "More specifically, the application provides techniques for determining suggested programs using closed caption or subtitle information BACKGROUND Television receivers may automatically suggest and record new programs based on the similarity of the new programs to other programs previously recorded by the user.", "However, the suggested programs may not always be of interest to the user, so alternative suggestion techniques may warrant further exploration.", "SUMMARY Described herein are systems, methods, and computer program products for providing suggested programming to a user based on closed caption or subtitle data from channels not being watched or recorded by a user.", "The systems, methods and computer program products may use the closed caption or subtitle data from the unwatched channels as a more comprehensive data source than just a program title or synopsis to provide better program suggestions to the user in real-time as the programs are broadcast on the unwatched channels.", "Advantageously, the disclosed systems, methods, and products permit new ways to utilize unused tuners and simultaneously allow users to have program content that may be of interest identified for them.", "As an example, a brief synopsis of a program available in a program guide may not actually describe any of the specific information depicted in the program, such as occurs for most news broadcasts or other programming.", "A user may have interest in seeing a news report on a particular subject, but the synopsis may only indicate that the news program is describing news of the day without a description of any of the specific news reports.", "Using the present invention, a user may be alerted when a subject of interest is depicted and the user may command their television receiver to display or record the news program so that the program can be immediately watched or watched at a later time.", "In a first aspect, methods are provided herein, such as methods for generating suggested programming for a user or viewer.", "An example method of this aspect comprises receiving, such as by a television receiver, video content using an inactive tuner of the television receiver; obtaining text data corresponding to an audio portion of the video content; evaluating or analyzing the text data to identify frequencies of words appearing in the text data; receiving input corresponding to determination of one or more user-designated keywords; storing the one or more user-designated keywords to a word list, such as a word list that includes at least a first keyword; determining, that the first keyword appears in the text data with a first frequency greater than a first threshold frequency; and generating a first interface for display on a display device in real-time upon determining that the first frequency is greater than the first threshold frequency, wherein the first interface includes a notification identifying a match of the first keyword.", "Optionally, the television receiver includes a plurality of tuners.", "It will be appreciated that the terms “inactive tuner,” “idle tuner,” and “unused tuner” may correspond to tuners of a television receiver that are unused for conventional display or recording purposes.", "For example, the inactive tuner may correspond to a tuner of the television receiver that is not being actively used to display live video content on the display device.", "As another example, the inactive tuner may correspond to a tuner of the television receiver that is not being actively used to record video content according to a recording schedule or timer.", "In this way, television receivers including a plurality of tuners may have any number of inactive tuners used for a non-conventional purpose in suggesting programming potentially of interest to a user or viewer.", "Various sources of the text data are contemplated.", "For example, obtaining the text data optionally includes decoding a closed caption portion of the video content to generate the text data.", "Alternatively or additionally, obtaining the text data includes decoding a subtitle portion of the video content to generate the text data.", "Optionally, obtaining the text data includes retrieving the text data from a network location, such as a location on an Internet server.", "Other techniques for obtaining the text data are contemplated.", "For example, obtaining the text data optionally includes processing the audio portion of the video content using a speech-to-text algorithm to generate the text data.", "Optionally, obtaining the text data includes rendering the video content with embedded closed captions or subtitles and generating the text data by performing character recognition on the embedded closed captions or subtitles.", "It will be appreciated that certain methods for generating the text data may be computationally prohibitive for some systems, but these techniques may be viable for specially constructed television receivers, such as with processors specially configured for speech-to-text or optical character recognition, as well as television receivers exhibiting suitable processing resources.", "Optionally, the frequency of words in the text data are determined in order to allow for programming including repeated use of the same words to be identified as such.", "Such analysis allows for more flexible suggestion algorithms to be employed, such as algorithms in which the frequency of words in the text data are used to better identify program suggestions.", "Optionally, evaluating or analyzing the text data includes generating a database including one or more words in the text data and tracking appearances of the one or more words in the text data using the database.", "Optionally, each word is assigned a unique identifier to simplify the database, processing of the text data, and/or matching words in the text data to a keyword.", "Optionally, common words, such as pronouns, conjunctions, prepositions, articles, etc., may be removed or excluded from the analysis in order not to obscure the subject of the programming.", "Optionally, the list of removed or excluded words is user selectable or editable.", "The keywords used for matching may be user determined or suggested for the user.", "For example, the input may optionally correspond to user entry of one or more user-designated keywords.", "Optionally, the input corresponds to selection of one or more user-designated keywords from a word list.", "The word list may be user selectable or editable.", "Optionally, the keywords used for matching may be automatically determined.", "For example, programs watched or recorded by the user may have their text data scanned and analyzed to determine commonly used words and some of these words, such as the most common words, may be automatically added to the word list or may be suggested to the user for adding to the word list.", "Optionally, a method of this aspect comprises or further comprises automatically adding one or more keywords to the word list without user input.", "Alternatively or additionally, a method of this aspect comprises or further comprises generating the word list by monitoring recorded or watched text data corresponding to audio portions of at least one of video content recorded by the television receiver and video content output by the television receiver for immediate display on the display device; evaluating the recorded or watched text data to rank words appearing in the watched or recorded text data by frequency; and adding one or more words appearing in the recorded or watched text data having rankings greater than a threshold ranking to the word list.", "Optionally, common words, such as pronouns, conjunctions, prepositions, articles, etc., may be removed from the analysis or When words appearing in the text data match words in the word list, it may be desirable to ensure that the matched word appears in the text data multiple times before suggesting the programming to a user or viewer.", "This may eliminate or reduce false positive detections or suggested programming that is not of interest to the user.", "Optionally, the first threshold frequency is user selectable.", "For example, the first threshold frequency may correspond to a specific number of appearances or occurrences of keywords in the text data.", "Optionally, the first threshold frequency may correspond to 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 occurrences of a match of words in the text data to keywords in the word list.", "Optionally, the first threshold frequency corresponds to a specific number of appearances or occurrences of keywords in the text data within a specific amount of time, such as N or more occurrences within 10 seconds, N or more occurrences within 30 seconds, N or more occurrences within 60 seconds, N or more occurrences within 5 minutes, or N or more occurrences within 15 minutes, where N represents a threshold number, such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, etc.", "It may also or alternatively be useful to detect matches of more than one word in order to eliminate or reduce false positive detections or suggested programming that is not of interest to the user.", "For example, it may be useful to match words in the text data to 1, 2, 3, 4, or 5 keywords in the word list.", "For example, the word list may optionally include a second keyword and methods of this aspect may comprise or further comprise determining that the second keyword appears in the text data with a second frequency greater than a second threshold frequency.", "Optionally, generating the first interface includes generating the first interface in real-time upon determining that both the first frequency is greater than the first threshold frequency and the second frequency is greater than the second threshold frequency.", "Optionally, the first interface includes a notification identifying a match of the first keyword, the second keyword, or both the first keyword and the second keyword.", "Various algorithms may be used to determine that the first keyword appears in the text data with the first frequency greater than the first threshold frequency.", "For example, determining that the first keyword appears in the text data with the first frequency greater than the first threshold frequency may include comparing words appearing in the text data having frequencies greater than the first threshold frequency with the first keyword to determine the match.", "Alternatively or additionally, determining that the first keyword appears in the text data with the first frequency greater than the first threshold frequency includes searching a database including one or more words in the text data using the first keyword to identify a number or frequency of appearances of the first keyword in the text data; and determining that the number or frequency of appearances of the first keyword in the text data is greater than the first threshold frequency.", "An interactive interface may optionally be generated upon detection of a suitable match between a keyword and words in text data.", "The interactive interface may, for example, correspond to an element of a graphical user interface, an element of an electronic programming guide, or an overlay element provided on top of or alternative to video content being output for display on a display device.", "Optionally, the first interface requests selection of a command.", "Useful commands include, but are not limited to, at least one of a command to record the video content, a command to immediately display the video content, or a command to ignore the video content.", "Optionally, a method of this aspect may comprise or further comprise receiving user input corresponding to determination of a command to record the video content, immediately display the video content, or ignore the video content.", "Optionally, the first interface corresponds to a notification overlayed on a graphical user interface, an electronic programming guide, or other video content being output for display on the display device.", "It will be appreciated that multiple tuners of a television receiver may be used for generating suggested programming in accordance with various aspects of the invention disclosed herein.", "Each tuner may optionally be utilized in identical or similar ways as described above, such as for generating suggested programming, displaying live broadcast content in real-time or with a small delay (such as a delay of between 0 and 30 seconds), or recording broadcast content.", "For example, a method of this aspect may comprise or further comprise receiving second video content using a second tuner of the television receiver; and outputting an output signal corresponding to the second video content for displaying the second video content on a display device.", "Alternatively or additionally, a method of this aspect may comprise or further comprise receiving second video content using a second tuner of the television receiver; and recording the second video content to a local storage medium.", "Alternatively or additionally, a method of this aspect may comprise or further comprise receiving second video content using a second inactive tuner of the television receiver; obtaining second text data corresponding to audio of the second video content; evaluating the second text data to identify second frequencies of words appearing in the second text data; determining that a second keyword appears in the second text data with a second frequency greater than a second threshold frequency; and generating a second user interactive interface for display on a display device in real-time upon determining that the second frequency is greater than the second threshold frequency, such as a second user interactive interface that indicates a second match of the second keyword.", "Optionally, the program suggestion aspects described herein may be activated or deactivated by a user, as desired.", "It will be appreciated that the program suggestion aspects may be referred to herein as a “scanning service,” since the text data of the video content may be scanned in real-time to identify word matches for use in suggesting programming or content to a user or viewer.", "For example, a method of this aspect may comprise or further comprise generating an additional interface that includes an item for activating a scanning service using one or more inactive tuners of the television receiver; and receiving input corresponding to selection of the item for activating the scanning service.", "Alternatively or additionally, a method of this aspect may comprise or further comprise generating an additional interface that includes an item for deactivating a scanning service using one or more inactive tuners of the television receiver; receiving input corresponding to selection of the item for deactivating the scanning service; and stopping the scanning service.", "Optionally, stopping includes one or more of stopping receiving the video content using the inactive tuner of the television receiver; stopping obtaining text data corresponding to the audio portion of the video content; stopping evaluating the text data to identify frequencies of words appearing in the text data; and stopping determining that the first keyword appears in the text data with the first frequency greater than the first threshold frequency.", "In another aspect, systems are provided.", "System of various embodiments provided herein may perform any of the above methods.", "For example, a system of this aspect may comprise one or more processors; a plurality of tuners communicatively coupled with the one or more processors; an audio-video output interface communicatively coupled with the one or more processors; and a non-transitory computer readable storage medium communicatively coupled with and readable by the one or more processors and having stored therein processor-readable instructions that, when executed by the one or more processors, cause the one or more processors to perform operations including: receiving video content using an inactive tuner of the plurality of tuners; obtaining text data corresponding to an audio portion of the video content; evaluating the text data to identify frequencies of words appearing in the text data; receiving input corresponding to determination of one or more user-designated keywords; storing the one or more user-designated keywords to a word list, such as a word list that includes at least a first keyword; determining that the first keyword appears in the text data with a first frequency greater than a first threshold frequency; and generating a first interface for output by the audio-video output interface for displaying on a display device in real-time upon determining that the first frequency is greater than the first threshold frequency, such as a first interface that includes a notification identifying a match of the first keyword.", "Optionally, the inactive tuner corresponds to a tuner of the plurality of tuners that is not being actively used to display live video content on the display device.", "Optionally, the inactive tuner corresponds to a tuner of the television receiver that is not being actively used to record video content according to a recording schedule or timer.", "Optionally, obtaining the text data includes decoding a closed caption portion of the video content to generate the text data.", "Optionally, obtaining the text data includes decoding a subtitle portion of the video content to generate the text data.", "Optionally, obtaining the text data includes retrieving the text data from a network location, such as an Internet server.", "Optionally, obtaining the text data includes processing the audio portion of the video content using a speech-to-text algorithm to generate the text data.", "Optionally, obtaining the text data includes rendering the video content with embedded closed captions or subtitles and generating the text data by performing character recognition on the embedded closed captions or subtitles.", "Optionally, evaluating includes generating a database including one or more words in the text data and tracking appearances of the one or more words in the text data using the database.", "Optionally, the input corresponds to user entry of one or more user-designated keywords.", "Optionally, the input corresponds to selection of one or more user-designated keywords from a word list.", "Optionally, one or more keywords are added to the word list automatically and without user input.", "Optionally, the operations include or further include generating the word list.", "For example, generating the word list optionally includes monitoring recorded or watched text data corresponding to audio portions of at least one of video content recorded by the television receiver and video content output by the television receiver for immediate display on the display device; evaluating the recorded or watched text data to rank words appearing in the watched or recorded text data by frequency; and adding one or more words appearing in the recorded or watched text data having rankings greater than a threshold ranking to the word list.", "Optionally, the first threshold frequency is user selectable.", "Optionally, the word list includes a second keyword.", "Optionally, the operations include or further include determining that the second keyword appears in the text data with a second frequency greater than a second threshold frequency, and generating the first interface includes generating the first interface in real-time upon determining that both the first frequency is greater than the first threshold frequency and the second frequency is greater than the second threshold frequency, such that the first interface includes the notification identifying a match of the first keyword, the second keyword, or both the first keyword and the second keyword.", "Optionally, the first threshold frequency corresponds to a specific number of appearances, as described above with reference to the disclosed methods.", "Optionally, the first threshold frequency corresponds to a specific number of appearances within a specific amount of time, as described above with reference to the disclosed methods.", "Optionally, determining that the first keyword appears in the text data with the first frequency greater than the first threshold frequency includes comparing words appearing in the text data having frequencies greater than the first threshold frequency with the first keyword to determine the match.", "Optionally, determining that the first keyword appears in the text data with the first frequency greater than the first threshold frequency includes searching a database including one or more words in the text data using the first keyword to identify a number or frequency of appearances of the first keyword in the text data; and determining that the number or frequency of appearances of the first keyword in the text data is greater than the first threshold frequency.", "Optionally, the first interface requests selection of a command, wherein the command corresponds to at least one of record the video content, immediately display the video content, or ignore the video content.", "Optionally, the operations include or further include receiving user input corresponding to determination of a command to record the video content, immediately display the video content, or ignore the video content.", "Optionally, the notification is overlayed on a graphical user interface, an electronic programming guide, or other video content being output for display on the display device.", "Optionally, the operations include or further include receiving second video content using a second tuner of the television receiver; and outputting an output signal corresponding to the second video content for displaying the second video content on a display device.", "Optionally, the operations include or further include receiving second video content using a second tuner of the television receiver; and recording the second video content to a local storage medium.", "Optionally, the operations include or further include receiving second video content using a second inactive tuner of the television receiver; obtaining second text data corresponding to audio of the second video content; evaluating the second text data to identify second frequencies of words appearing in the second text data; determining that a second keyword appears in the second text data with a second frequency greater than a second threshold frequency; and generating a second user interactive interface for display on a display device in real-time upon determining that the second frequency is greater than the second threshold frequency, such as a second user interactive interface that indicates a second match of the second keyword.", "Optionally, the operations include or further include generating a second interface that includes an item for activating a scanning service using one or more inactive tuners of the television receiver; and receiving, by the television receiver, input corresponding to selection of the item for activating the scanning service.", "Optionally, the operations include or further include generating, by the television receiver, a second interface that includes an item for deactivating a scanning service using one or more inactive tuners of the television receiver; receiving, by the television receiver, input corresponding to selection of the item for deactivating the scanning service; and stopping, by the television receiver, the scanning service.", "Optionally, stopping includes one or more of stopping receiving the video content using the inactive tuner of the television receiver; stopping obtaining text data corresponding to the audio portion of the video content; stopping evaluating the text data to identify frequencies of words appearing in the text data; and stopping determining that the first keyword appears in the text data with the first frequency greater than the first threshold frequency.", "It will again be appreciated that the systems of this aspect may optionally perform any of the methods described above.", "For example, the instructions stored on the non-transitory computer readable medium, when executed by the one or more processors, may cause the one or more processors to perform any of the methods described above.", "In another aspect, computer program products are provided.", "In some embodiments, a computer program product of this aspect may correspond to a computer program, stored on a non-transitory computer readable storage medium.", "The computer program may correspond to processor executable instructions for performing any of the methods described above.", "The computer program may be suitable for loading on and or execution by a system, such as a television receiver.", "A non-transitory computer readable storage medium of this aspect may comprise instructions that, when executed by one or more processors, cause the one or more processors to perform operations including: receiving video content using an inactive tuner of a television receiver; obtaining text data corresponding to an audio portion of the video content; evaluating the text data to identify frequencies of words appearing in the text data; receiving input corresponding to determination of one or more user-designated keywords; storing the one or more user-designated keywords to a word list, such as a word list that includes at least a first keyword; determining that the first keyword appears in the text data with a first frequency greater than a first threshold frequency; and generating a first interface for display on a display device in real-time upon determining that the first frequency is greater than the first threshold frequency, such as a first interface that includes a notification identifying a match of the first keyword.", "Optionally, the television receiver includes a plurality of tuners, and the inactive tuner corresponds to one of the plurality of tuners.", "Optionally, the inactive tuner corresponds to a tuner of the television receiver that is not being actively used to display live video content on the display device.", "Optionally, the inactive tuner corresponds to a tuner of the television receiver that is not being actively used to record video content according to a recording schedule or timer.", "Optionally, obtaining the text data includes decoding a closed caption portion of the video content to generate the text data.", "Optionally, obtaining the text data includes decoding a subtitle portion of the video content to generate the text data.", "Optionally, obtaining the text data includes retrieving the text data from a network location.", "Optionally, obtaining the text data includes processing the audio portion of the video content using a speech-to-text algorithm to generate the text data.", "Optionally, obtaining the text data includes rendering the video content with embedded closed captions or subtitles and generating the text data by performing character recognition on the embedded closed captions or subtitles.", "Optionally, evaluating includes generating a database including one or more words in the text data and tracking appearances of the one or more words in the text data using the database.", "Optionally, the input corresponds to user entry of one or more user-designated keywords.", "Optionally, the input corresponds to selection of one or more user-designated keywords from a word list.", "Optionally, one or more keywords are automatically added to the word list without user input.", "Optionally, the operations include or further include generating the word list.", "Optionally, generating the word list includes monitoring recorded or watched text data corresponding to audio portions of at least one of video content recorded by the television receiver and video content output by the television receiver for immediate display on the display device; evaluating the recorded or watched text data to rank words appearing in the watched or recorded text data by frequency; and adding one or more words appearing in the recorded or watched text data having rankings greater than a threshold ranking to the word list.", "Optionally, the first threshold frequency is user selectable.", "Optionally, the word list includes a second keyword.", "Optionally, the operations include or further include determining that the second keyword appears in the text data with a second frequency greater than a second threshold frequency.", "Optionally, generating the first interface includes generating the first interface in real-time upon determining that both the first frequency is greater than the first threshold frequency and the second frequency is greater than the second threshold frequency, such as where the first interface includes the notification identifying a match of the first keyword, the second keyword, or both the first keyword and the second keyword.", "Optionally, the first threshold frequency corresponds to a specific number of appearances, such as described above with reference to the disclosed methods.", "Optionally, the first threshold frequency corresponds to a specific number of appearances within a specific amount of time, such as described above with reference to the disclosed methods.", "Optionally, determining that the first keyword appears in the text data with the first frequency greater than the first threshold frequency includes comparing words appearing in the text data having frequencies greater than the first threshold frequency with the first keyword to determine the match.", "Optionally, determining that the first keyword appears in the text data with the first frequency greater than the first threshold frequency includes searching a database including one or more words in the text data using the first keyword to identify a number or frequency of appearances of the first keyword in the text data; and determining that the number or frequency of appearances of the first keyword in the text data is greater than the first threshold frequency.", "Optionally, the first interface requests selection of a command, such as a command that corresponds to at least one of record the video content, immediately display the video content, or ignore the video content.", "Optionally, the operations include or further include: receiving user input corresponding to determination of a command to record the video content, immediately display the video content, or ignore the video content.", "Optionally, the notification is overlayed on a graphical user interface, an electronic programming guide, or other video content being output for display on the display device.", "Optionally, the operations include or further include receiving second video content using a second tuner of the television receiver; and outputting an output signal corresponding to the second video content for displaying the second video content on a display device.", "Optionally, the operations include or further include receiving second video content using a second tuner of the television receiver; and recording the second video content to a local storage medium.", "Optionally, the operations include or further include receiving second video content using a second inactive tuner of the television receiver; obtaining second text data corresponding to audio of the second video content; evaluating the second text data to identify second frequencies of words appearing in the second text data; determining that a second keyword appears in the second text data with a second frequency greater than a second threshold frequency; and generating a second user interactive interface for display on a display device in real-time upon determining that the second frequency is greater than the second threshold frequency, such as a second user interactive interface that indicates a second match of the second keyword.", "Optionally, the operations include or further include generating a second interface that includes an item for activating a scanning service using one or more inactive tuners of the television receiver; and receiving input corresponding to selection of the item for activating the scanning service.", "Optionally, the operations include or further include generating a second interface that includes an item for deactivating a scanning service using one or more inactive tuners of the television receiver; receiving input corresponding to selection of the item for deactivating the scanning service; and stopping the scanning service.", "Optionally, stopping includes one or more of stopping receiving the video content using the inactive tuner of the television receiver; stopping obtaining text data corresponding to the audio portion of the video content; stopping evaluating the text data to identify frequencies of words appearing in the text data; and stopping determining that the first keyword appears in the text data with the first frequency greater than the first threshold frequency.", "Without wishing to be bound by any particular theory, there can be discussion herein of beliefs or understandings of underlying principles relating to the invention.", "It is recognized that regardless of the ultimate correctness of any mechanistic explanation or hypothesis, an embodiment of the invention can nonetheless be operative and useful.", "BRIEF DESCRIPTION OF THE DRAWINGS A further understanding of the nature and advantages of various embodiments, examples, and aspects may be realized by reference to the following figures.", "In the appended figures, similar components or features may have the same reference label.", "Further, various components of the same type may be distinguished by following the reference label by a dash and a second label that distinguishes among the similar components.", "If only the first reference label is used in the specification, the description is applicable to any one of the similar components having the same first reference label irrespective of the second reference label.", "FIG.", "1 provides an overview of an example method for generating programming suggestions.", "FIG.", "2 illustrates an example of a satellite television distribution system.", "FIG.", "3 provides an overview of an example method for generating a word list.", "FIG.", "4 provides an overview of the generation of an example word list.", "FIG.", "5 provides an overview of an example method for generating programming suggestions.", "FIG.", "6 provides an overview of analysis of text data for matches.", "FIG.", "7A and FIG.", "7B provide example receiver interfaces.", "FIG.", "8 provides an overview of analysis of text data for matches.", "FIG.", "9 provides a block diagram illustration of a receiver incorporating program suggestion features.", "FIG.", "10 provides a schematic illustration of aspects of a receiver incorporating a program suggestion module.", "FIG.", "11 provides a block diagram of an example computing device.", "DETAILED DESCRIPTION In embodiments, the present invention provides systems, methods, and computer program products for suggesting television programs to a user by, for example, analyzing closed caption or subtitle content of unwatched or unrecorded video content to determine if the video content is of interest to the user.", "The user may indicate one or more keywords for use in the analysis and the analysis may scan the text of the closed caption or subtitle content to identify matches to the keywords.", "Beside user input keywords, the keywords may also be determined through analysis of video content watched or recorded by the user to determine frequently encountered words.", "These frequently encountered words may automatically be used in matching the text of the closed caption or subtitle content.", "The users may also or alternatively select particular words of the frequently encountered words to use for matching.", "In addition to providing better program recommendations for users, embodiments described herein also allow users to fine tune the suggestion algorithm to allow for even higher quality suggestions.", "For example, the user may indicate a threshold number of match occurrences for a particular keyword.", "As another example, the user may indicate that multiple keywords must match before a notification is generated.", "In this way, the user may be able to optimize the suggestions made to the user to eliminate or reduce suggestions of programs that are not of interest to the user.", "FIG.", "1 provides an overview of an example method 100 for providing program recommendations to a user.", "At block 105, video content is received at an inactive tuner.", "For example, one or more broadcast programs may be received at an inactive tuner, which may correspond to a transponder stream containing the one or more broadcast programs.", "The inactive tuners may correspond to unused tuners of a television receiver, such as tuners that are standing by idle, awaiting instructions for obtaining live video content for immediate display to a display device or for obtaining live video content and storing or recording the video content to a storage device for later playback to a display device.", "It will be appreciated that a television receiver may include many tuners, such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, etc., and, at any one time, one or more of these tuners may not be actively used for viewing or recording video content and therefore remain available for other uses.", "Advantageously, these unused, inactive, or idle tuners may find a use according to the present disclosure, such as for making program recommendations to the user, by allowing for monitoring of text data included with the video content, such as in a closed caption or subtitle portion of the video content for unwatched and/or unrecorded channels in the background while the television receiver may optionally be displaying live content or recording content using active tuners.", "At block 110, text data corresponding to the video content is obtained.", "The text data may be directly obtained from a closed caption or subtitle portion of the video content.", "It will be appreciated that the terms “closed caption” and “subtitle” are used interchangeably herein to refer to any of the various worldwide standards used for providing textual captions for audio portions of a video program.", "For example, various subtitle and/or closed caption streams may be integrated into video content of various formats.", "As one specific example, a closed caption feed may be integrated into an MPEG-2 stream according to the Consumer Electronics Association (CEA) 708 standard.", "As another example, a closed caption feed may be integrated into an analog NTSC transmission according to the Electronic Industries Alliance (EIA) 608 standard.", "Other implementations, such as teletext, may similarly be used.", "These closed caption streams may be suitably decoded using standard techniques to provide a feed of text data as the closed caption stream is received.", "It will be appreciated that the closed caption for the original language (e.g., English) or a secondary or translated language (e.g., Spanish), may be used for the analysis and program suggestion techniques disclosed herein.", "At block 115, the text data is analyzed or evaluated to identify word frequencies.", "Optionally, one or more words in the text data are removed or are otherwise not counted during the analysis or evaluation of word frequencies.", "For example, prepositions, pronouns, articles, etc., may be removed or ignored to simplify the word frequency analysis and determination of useful words for identification of program suggestions.", "Other words may be removed or ignored as dictated by the user.", "As one example of the analysis of the text data for identification of frequencies of remaining words in the text data, each word may be subjected to a comparison to determine whether the word has been encountered previously and a count related to the word incremented each time the word is encountered.", "Such analysis may include creation of a database including entries for each word and/or an identifier associated with each word and a count associated with each word.", "At block 120, one or more user-designated keywords may be received.", "The user-designated keywords may be user input or selected to correspond to words associated with user interests.", "At block 122, one or more keywords may be automatically or dynamically determined, such as without user input.", "For example, programs displayed or recorded may undergo a similar analysis as occurs at block 115 to identify a frequency of words in the displayed or recorded programs and one or more of the most frequent words may be automatically added to the word list.", "Optionally, the user may select one or more of the words from the displayed or recorded programs to add to the word list.", "At block 125, the keywords are stored to a word list, which may correspond to a database, text file, or other suitable storage type for keeping track of keywords relating to programs of interest to the user.", "It will be appreciated that the user may also manually edit and add words to or eliminate words from the word list, such as by using a graphical user interface of a television receiver and providing suitable input, such as text entry, item selection and deletion.", "Optionally, language tools may be made available, such as a dictionary or thesaurus, to allow a user to expand, correct, or update a word list, such as to include synonyms, correct spelling mistakes, etc.", "Optionally, synonyms, plurals, singulars, etc., may be automatically added to and stored to the word list, and this option may be user activated or deactivated.", "At block 130, it is determined that one or more keywords from the word list appear in the text data.", "This may occur by comparing each word in the text data with the keywords in the word list to track the number of occurrences of various keywords in the text data.", "Optionally, use of a database containing the word list may facilitate and expedite the determination.", "For example, a database containing the keywords may be queried using each word in the text data.", "If the text data is analyzed to determine the frequency of the words in the text data, the determination may use those words having a frequency greater than a threshold frequency to identify matches.", "This latter option may conserve computing resources and/or expedite the determination by not analyzing words having a number of occurrences in the text data less than the threshold.", "At block 135, a notification of the keyword match is generated.", "The notification may be by any of various mechanisms, such as generating an interface for output by a display, generating an overlay on a video or electronic program guide, displaying an indicator or icon on an interface, or transmitting a message to a user device, such as by email or text message or an application notification.", "The notification may indicate one or more of the keyword or keywords that match, the number of occurrences of the keyword or keywords, the channel the match was identified on, the program the match was identified in, a time the match was identified, the occurrence threshold (if any).", "The notification may also include a query for user instructions, such as a request to watch or display the video content the match was identified in, to record the video content the match was identified in, or to ignore the video content the match was identified in.", "Optionally, the query may allow or request that a user flag or otherwise store details about the video content the match was identified in, such as program name, broadcast time, broadcast channel, etc., which may facilitate the user keeping track of programs that may be related to various keywords, or facilitate the user watching or recording the video content at a later broadcast time.", "At block 140, a command may be identified corresponding to an action for a television receiver to take in response to detecting a keyword match.", "Example commands include a command to watch the video content, to record the video content, or to ignore the video content.", "Optionally, a command to flag the video content, as described above, may be identified.", "The command may correspond to user input received by a television receiver, such as by way of a remote control or other user input device Referring now to FIG.", "2, an example media content distribution system 200 is shown in which aspects of the present disclosure may be implemented.", "For brevity, the system 200 is depicted in a simplified and conceptual form, and may generally include more or fewer systems, devices, networks, and/or other components as desired.", "Further, number and type of features or elements incorporated within the system 200 may or may not be implementation-specific, and at least some of the aspects of the system 200 may be similar to a cable television distribution system, an IPTV (Internet Protocol Television) content distribution system, and/or any other type of media or content distribution system.", "Although the depicted system 200 identifies a satellite based content distribution system, the invention may be implemented and/or used with any type of television or video distribution system, such as cable, terrestrial/over the air, IPTV, over-the-top, on demand, subscription-based, network-based, etc.", "Optionally, the depicted system 200 may be used with a digital video recorder (DVR) system, where content received from a television or video distribution system is recorded for later playback.", "The example system 200 may include a service provider 202, a satellite uplink 204, a plurality of orbiting (e.g., geosynchronous) satellites 206a, 206b, 206c, a satellite dish 208, a primary television receiver 210, a plurality of secondary television receivers 212a, 212b, and a plurality of televisions 214a, 214b, 214c, 214d.", "The system 200 may also include at least one network 220 that establishes a bi-directional communication path for data transfer between and among any of the primary television receiver 210, secondary television receivers 212a-b, and televisions 214a-d. Optionally, one or more of television receiver 210 and secondary television receivers 212a-b may be directly or indirectly connected or wired to satellite dish 208 for receiving broadcast content.", "In some embodiments, the network 220 may further establish a bi-directional communication path for data transfer between the primary television receiver 210 and the service provider 202.The network 220 is intended to represent any number of terrestrial and/or non-terrestrial network features or elements.", "For example, the network 220 may incorporate or exhibit any number of features or elements of various wireless and/or hardwired packet-based communication networks such as, for example, a WAN (Wide Area Network) network, a HAN (Home Area Network) network, a LAN (Local Area Network) network, a WLAN (Wireless Local Area Network) network, the Internet, a cellular communications network, and/or any other type of communication network(s) configured such that data may be transferred between and among respective elements of the example system 200.The primary television receiver 210, and the secondary television receivers 212a-b, as described throughout may generally be any type of television receiver, such as a set top box or TV dongle, for example.", "In another example, the primary television receiver 210, and the secondary television receivers 212a-b, may exhibit functionality integrated as part of or into a television, monitor, a digital video recorder (DVR), a computing device, such as a tablet computing device, or any other computing system or device, as well as variations thereof.", "Optionally, the primary television receiver 210, and the secondary television receivers 212a-b, may exhibit functionality integrated as part of or into a software application, which may be particularly useful in IPTV or over-the-top systems, where the physical infrastructure of the service provider uplink, downlink, and satellites are not required and all video programming may be transmitted from service provider 202 to the primary television receiver 210 and/or the secondary television receivers 212a-b via network 220.It will be appreciated that the primary television receiver 210 and the network 220, together with the secondary television receivers 212a-b, and televisions 214a-d may form at least a portion of a particular home computing network, and may each be respectively configured so as to enable communications in accordance with any particular communication protocol(s) and/or standard(s) including, for example, TCP/IP (Transmission Control Protocol/Internet Protocol), DLNA/DTCP-IP (Digital Living Network Alliance/Digital Transmission Copy Protection over Internet Protocol), HDMI/HDCP (High-Definition Multimedia Interface/High-Bandwidth Digital Content Protection), etc.", "In practice, the satellites 206a-c may be configured to receive uplink signals 222a, 222b from the satellite uplink 204.In this example, the uplink signals 222a-b may contain one or more transponder streams of particular data or content, such as content streams, like particular television channels, broadcast content, video content, or other data feeds, that is supplied by the service provider 202.For example, each of the respective uplink signals 222a-b may contain various media content such a plurality of encoded HD (High Definition) television channels, various SD (Standard Definition) television channels, video content, audio programming, on-demand programming, programming information, advertisements, and/or any other content in the form of at least one transponder stream, and in accordance with an allotted carrier frequency and bandwidth.", "In this example, different media content may be carried using different ones of the satellites 206a-c. Further, different media content may be carried using different transponders of a particular satellite (e.g., satellite 206a); thus, such media content may be transmitted at different frequencies and/or different frequency ranges.", "For example, a first and second television channel may be carried on a first carrier frequency over a first transponder of satellite 206a, and a third, fourth, and fifth television channel may be carried on second carrier frequency over a first transponder of satellite 206b, or, the third, fourth, and fifth television channel may be carried on a second carrier frequency over a second transponder of satellite 206a, etc.", "The satellites 206a-c may further be configured to relay the uplink signals 222a-b to the satellite dish 208 as downlink signals 224a, 224b.", "Similar to the uplink signals 222a-b, each of the downlink signals 224a-b may contain one or more transponder streams of particular data or content, such as various encoded and/or at least partially electronically scrambled television channels, advertisements, video content, on-demand programming, etc., in accordance with an allotted carrier frequency and bandwidth.", "The downlink signals 224a-b, however, may not necessarily contain the same or similar content as a corresponding one of the uplink signals 222a-b.", "For example, the uplink signal 222a may include a first transponder stream containing at least a first group or grouping of television channels, and the downlink signal 224a may include a second transponder stream containing at least a second, different group or grouping of television channels.", "In other examples, the first and second group of television channels may have one or more television channels in common.", "In sum, there may be varying degrees of correlation between the uplink signals 222a-b and the downlink signals 224a-b, both in terms of content and underlying characteristics.", "Continuing with the example implementation scenario, the satellite dish 208 may be provided for use to receive one or more content streams, for example live, prerecorded or on-demand television programming or other video content, such as on a subscription basis, provided by the service provider 202, satellite uplink 204, and/or satellites 206a-c. For example, the satellite dish 208 may be configured to receive particular transponder streams, or downlink signals 224a-b, from one or more of the satellites 206a-c. Based on the characteristics of the primary television receiver 210 and/or satellite dish 208, however, it may only be possible to capture transponder streams from a limited number of transponders concurrently.", "For example, a tuner of the primary television receiver 210 may only be able to tune to a single transponder stream from a transponder of a single satellite, such as satellite 206a, at a time.", "In certain embodiments, however, a tuner of primary television receiver 210 may be able to simultaneously receive multiple transponder streams.", "Additionally, the primary television receiver 210, which is communicatively coupled to the satellite dish 208, may subsequently select a content stream via a tuner, decode, and relay particular transponder streams to the television 214c or 214d for display thereon.", "For example, the satellite dish 208 and the primary television receiver 210 may, respectively, be configured to receive, decode, and relay at least one premium high definition (HD) formatted television channel to one or both of televisions 214c-d.", "Programming or content associated with the HD channel may generally be presented “live,” or from a recording as previously stored on, by, or at the primary television receiver 210.In this example, the HD channel may be output to the televisions 214c-d in accordance with the HDMI/HDCP content protection technologies.", "Other embodiments are possible.", "For example, in some embodiments, the HD channel may be output to the televisions 214c-d in accordance with the MoCA® (Multimedia over Coax Alliance) home entertainment networking standard.", "Still other embodiments are possible.", "Further, the primary television receiver 210 may select, via one or more tuners, decode, and relay particular transponder streams to one or both of the secondary television receivers 212a-b, which may in turn relay particular transponder streams to a corresponding one of the television 214a and the television 214a for display thereon.", "For example, the satellite dish 208 and the primary television receiver 210 may, respectively, be configured to receive, decode, and relay at least one television channel to the television 214a by way of the secondary television receiver 212a.", "Similar to the above-example, the television channel may generally be presented “live,” or from a recording as previously stored on the primary television receiver 210, and may be output to the television 214a by way of the secondary television receiver 212a in accordance with a particular content protection technology and/or networking standard.", "Other embodiments are possible.", "In various embodiments, input commands may be received by primary television receiver 210 or secondary television receivers 212a-b, such as for selection of programming for display on televisions 214a-d.", "Input commands may be received from one or more input devices connected to network 220 or one or more input devices directly or wirelessly connected to primary television receiver 210 or secondary television receivers 212a-b.", "For example, an input device may exemplified as a remote control, a keyboard, a mouse, a smartphone, a touchpad, etc.", "FIG.", "3 provides an overview of an example method 300 for generating a word list.", "In FIG.", "3, at block 305, Tuner #1 is tuned to channel #100 for immediate display on a display device.", "Channel #100 may correspond to a channel being watched by a user.", "In some embodiments, it may be assumed that if a channel is manually tuned to a particular program or channel, that program or channel may be of interest to the user and so may be used for automatically populating a word list.", "It will be appreciated that the frequency of words in a program of interest may be useful to track, as words that appear more frequently in a program may indicate a subject or content of the program.", "At block 310, a buffer is populated with the text data from a closed caption stream associated with the watched channel or program.", "The buffer may be contained in a memory, such as a random access memory, for use in analysis.", "Alternatively or additionally, the buffer may be stored to a storage medium, such as a non-transitory computer readable storage medium.", "At block 315, a next word in the buffer is analyzed.", "In this way, each word in the text data can be analyzed sequentially as the word is received.", "Optionally, words can be analyzed in groups of 2 or more than 2, such as to better analyze compound words, hyphenated words, or otherwise related words.", "At block 320, a word undergoing analysis is subjected to a determination of whether the word appears in a remove list.", "As described above, a remove list may include words of relative unimportance, such as articles, conjunctions, prepositions, pronouns, and other user defined words.", "The determination may include a comparison of the word with each word in the remove list.", "Alternatively or additionally, the determination may correspond to querying a database including the words in the remove list to determine whether the word undergoing analysis appears in the remove list.", "If the word undergoing analysis appears in the remove list, the word may be ignored, at block 325, and the process returns to block 315 for continued processing of additional words in the text data from the closed caption buffer.", "If the word undergoing analysis does not appear in the remove list, the word may undergo additional analysis at block 330.At block 330, the word is subjected to a determination of whether the word already appears in the word list.", "The determination may include a comparison of the word with each word already in the word list.", "Alternatively or additionally, the determination may correspond to querying a database including the words in the word list to determine whether the word undergoing analysis appears in the word list already.", "If the word already appears in the word list, the count associated with the word is simply incremented at block 335.If the word undergoing analysis does not appear in the word list already, it is added to the word list at block 340 and a count associated with the word is incremented at block 335.After the count is incremented at block 335, the process returns to block 315 for continued processing of additional words in the text data from the closed caption buffer.", "An example of the processing of text data from a closed caption stream is illustrated in FIG.", "4.Element 400 identifies text data used to populate a closed caption buffer.", "Each word in the closed caption buffer is processed in turn at block 405 to remove words from the remove list, identified at element 410.The remaining words are processed in turn at block 415 to identify a count or frequency of the words.", "The resultant word list is shown at element 420, and indicates that the most common word from the text data is “Siemian,” which appears three times.", "FIG.", "5 provides an overview of an example method 500 for analyzing text data using an inactive tuner.", "In FIG.", "5, at block 505, Tuner #2 is tuned to channel #200 for determining whether to suggest the program broadcast on this channel to the user.", "Channel #200 may correspond to a channel or program that is not being watched or recorded.", "At block 510, a buffer is populated with the text data from a closed caption stream associated with the channel or program.", "The buffer may be contained in a memory, such as a random access memory, for use in analysis.", "Alternatively or additionally, the buffer may be stored to a storage medium, such as a non-transitory computer readable storage medium.", "At block 515, a next word in the buffer is analyzed.", "In this way, each word in the text data can be analyzed sequentially as the word is received.", "Optionally, words can be analyzed in groups of 2 or more than 2, such as to better analyze compound words, hyphenated words, or otherwise related words.", "At block 520, a word undergoing analysis is subjected to a determination of whether the word appears in a remove list.", "The determination may include a comparison of the word with each word in the remove list.", "Alternatively or additionally, the determination may correspond to querying a database including the words in the remove list to determine whether the word undergoing analysis appears in the remove list.", "If the word undergoing analysis appears in the remove list, the word may be ignored, at block 525, and the process returns to block 515 for continued processing of additional words in the text data from the closed caption buffer.", "If the word undergoing analysis does not appear in the remove list, the word may undergo additional analysis at block 530.At block 530, the word is subjected to a determination of whether the word appears in the word list and thus matches a keyword.", "The determination may include a comparison of the word with each word in the word list.", "Alternatively or additionally, the determination may correspond to querying a database including the words in the word list to determine whether the word undergoing analysis appears in the word list.", "If the word undergoing analysis does not appear in the word list, the word may be ignored, at block 525, and the process returns to block 515 for continued processing of additional words in the text data from the closed caption buffer.", "If the word already appears in the word list, the word may undergo additional analysis at block 550.At block 535, the word is subjected to a determination of whether the word already appears in a match list.", "The determination may include a comparison of the word with each word already in the match list.", "Alternatively or additionally, the determination may correspond to querying a database including the words in the match list to determine whether the word undergoing analysis appears in the match list already.", "If the word already appears in the match list, the match count associated with the word is incremented at block 540.If the word undergoing analysis does not appear in the match list already, it is added to the match list at block 545 and a match count associated with the word is incremented at block 540.After the count is incremented at block 540, the process continues to block 550 for continued processing.", "At 550, the match count is analyzed to determine whether it is greater than, or greater than or equal to, the threshold frequency.", "If the match count is less than the threshold frequency, the process returns to block 515 for continued processing of additional words in the text data from the closed caption buffer.", "If the match count is greater than, or equal to, the threshold frequency, the process proceeds to block 555, where a popup is displayed on an interface, such as a graphical interface of a television receiver.", "The popup may provide a notification of the match or the match count exceeding the threshold, and may indicate a suggested program that the user may find of interest.", "The popup may query the user for input at 560, such as to request instructions whether to watch the channel or program, to record the channel or program, or to ignore the channel or program.", "If input is detected corresponding to a command to watch the channel or program, the channel or program is output for display at 565.If input is detected corresponding to a command to record the channel or program, the channel or program is recorded to storage at 570.If input is detected corresponding to a command to ignore the channel or program, the tuner may be tuned to the next unwatched channel at 575 and the process returns to block 510 for continued processing of additional words in the text data from the closed caption buffer.", "Alternatively or additionally, the query may request instructions regarding the match and the ignore command may cause only the match to be ignored so that the process returns to block 515 for continued processing of additional words in the text data from the closed caption buffer, such as to allow other matches to be found.", "An example of the processing of text data from a closed caption stream for matches with keyword in a word list is illustrated in FIG.", "6.Element 600 identifies text data used to populate a closed caption buffer.", "Each word in the closed caption buffer is processed in turn at block 605 to remove words from the remove list, identified at element 610.The remaining words are processed in turn at block 615 to identify matches with keywords in the word list, shown at 620.The resultant match list is shown at element 625, and indicates that the word from the text data “Siemian” matches three times, and is thus greater than the threshold match count, identified at 630 as two.", "FIG.", "7A shows an example receiver interface, which corresponds to a video content of a basketball game being displayed on a television 700.FIG.", "7B shows an example receiver interface where a popup 705 is displayed, such as upon detecting the match of the word “Siemian” indicated in FIG.", "6.The popup 705 includes a query for input for the user to select from among options, such as options to record, watch, or ignore the program detected as matching the keyword on channel #200.A user selectable default may be established to select a particular action when no instructions are received within a particular time.", "The particular time may also be user selectable.", "In FIG.", "7B, the “Ignore” option is identified as the default, and a countdown timer is optionally shown on the option, indicating that if no action is taken within 10 seconds, the ignore option may be selected.", "Another example of the processing of text data from a closed caption stream for matches with keyword in a word list is illustrated in FIG.", "8.Element 800 identifies text data used to populate a closed caption buffer.", "Each word in the closed caption buffer is processed in turn at block 805 to remove words from the remove list, identified at element 810.The remaining words are processed in turn at block 815 to identify matches with keywords in the word list, shown at 820 and compare match counts with the threshold value 830.The resultant match list is shown at element 825, and indicates that none of the keywords in the word list match the text data, so the match list is empty.", "FIG.", "9 illustrates an embodiment of a receiver 900 that makes use of a closed caption suggestion module.", "Embodiments of receiver 900 may include set top boxes (STBs), television receivers, and over-the-top receivers.", "As previously noted, in addition to being in the form of a STB, a receiver may be incorporated as part of another device, such as a television or other form of display device, such as a computer, smartphone, tablet, or other handheld portable electronic device.", "For example, a television may have an integrated receiver (which does not involve an external STB being coupled with the television).", "Receiver 900 may represent any one or more of receivers 210 and 212a-212b of FIG.", "2 and may be in the form of a STB that communicates with a display device such as a television.", "Receiver 900 may be incorporated as part of a television, such as televisions 214a-214d of FIG.", "2 or television 700 of FIGS.", "7A-7B, etc.", "Receiver 900 may include: processors 910 (which may include control processor 910-1, tuning management processor 910-2, and possibly additional processors), tuners 915, network interface 920, non-transitory computer-readable storage medium 925, electronic programming guide (EPG) database 930, networking information table (NIT) 940, digital video recorder (DVR) database 945 (which may include provider-managed television programming storage and/or user-defined television programming), on-demand programming 927, closed caption (CC) suggestion module 932, commercial database 946, user interface 950, decryption device 960, decoder module 933, interface 935, and/or descrambling engine 965.In various embodiments of receiver 900, fewer or greater numbers of components may be present.", "It should be understood that the various components of receiver 900 may be implemented using hardware, firmware, software, and/or some combination thereof.", "Functionality of components may be combined; for example, functions of descrambling engine 965 may be performed by tuning management processor 910-2.Further, functionality of components may be spread among additional components; for example, PID filters 955 may be handled by separate hardware from program map table 957.Receiver 900 may be in data communication with accessibility system 951, such as by way of network interface 920.Processors 910 may include those configured to perform processes such as tuning to a particular channel, accessing and displaying EPG information from EPG database 930, and/or receiving and processing input from a user.", "For example, processors 910 may include one or more processors dedicated to decoding video signals from a particular format, such as MPEG, for output and display on a television and for performing decryption, if required.", "It should be understood that the functions performed by various modules of FIG.", "9 may be performed using one or more processors.", "As such, for example, functions of descrambling engine 965 may be performed by control processor 910-1.Control processor 910-1 may communicate with tuning management processor 910-2.Control processor 910-1 may control the recording of television channels based on timers stored in DVR database 945.Control processor 910-1 may also provide commands to tuning management processor 910-2 when recording of a television channel is to cease.", "In addition to providing commands relating to the recording of television channels, control processor 910-1 may provide commands to tuning management processor 910-2 that indicate television channels to be output to decoder module 933 for output to a display device.", "Control processor 910-1 may also communicate with network interface 920 and user interface 950.Control processor 910-1 may handle incoming data from network interface 920, including network transport streams received from over-the-top service providers.", "Control processor 910-1 may handle incoming data from network interface 920, including network transport streams received from user interface 950, which may include user input received by way of one or more human interface devices.", "Additionally, control processor 910-1 may be configured to output data via network interface 920.Control processor 910 may also be configured to perform image and audio analysis, such as to identify contextual aspects present in an audio or video stream, for example facial recognition or voice recognition.", "Tuners 915 may include one or more tuners used to tune to transponders that include broadcasts of one or more television channels that may be received from a satellite or cable system, for example.", "In the illustrated embodiment of receiver 900, three tuners are present (tuner 915-1, tuner 915-2, and tuner 915-3).", "In other embodiments, two or more than three tuners may be present, such as four, six, eight, or sixteen tuners.", "Each tuner contained in tuners 915 may be capable of receiving and processing a single transponder stream from a satellite transponder at a given time, for example.", "As such, a single tuner may tune to a single transponder stream at a given time.", "If tuners 915 include multiple tuners, one tuner may be used to tune to a television channel on a first transponder stream for display using a television, while another tuner may be used to tune to a television channel on a second transponder for recording and viewing at some other time.", "If multiple television channels transmitted on the same transponder stream are desired, a single tuner of tuners 915 may be used to receive the signal containing the multiple television channels for presentation and/or recording.", "Tuners 915 may receive commands from tuning management processor 910-2.Such commands may instruct tuners 915 which frequencies are to be used for tuning.", "Network interface 920 may be used to communicate via an alternate communication channel with a television service provider, if such communication channel is available.", "The primary communication channel may be via satellite (which may be unidirectional to receiver 900) and the alternate communication channel (which may be bidirectional) may be via a network, such as the Internet.", "Referring back to FIG.", "2, receiver 210 may be able to communicate with television service provider system 202 via a network 220, such as the Internet.", "This communication may be bidirectional: data may be transmitted from receiver 210 to television service provider system 202 and from television service provider system 202 to receiver 210.Referring back to FIG.", "9, network interface 920 may be configured to communicate via one or more networks, such as the Internet, to communicate with television service provider system 202 of FIG.", "2.Other information may be transmitted and/or received via network interface 920.For example, commands, data, user input, etc.", "may be transmitted to control processor 910-1.For example, user input data received at a computer system or smartphone may be transmitted to receiver 900 by way of network interface 920.Storage medium 925 may represent one or more non-transitory computer-readable storage mediums.", "Storage medium 925 may include memory and/or a hard drive.", "Storage medium 925 may be used to store information received from one or more satellites and/or information received via network interface 920.Storage medium 925 may store information related to EPG database 930, CC suggestion module 932 and related preferences, other non-video/audio data 931, DVR database 945, commercial database 946, and/or on-demand programming 927.Recorded television programs may be stored using storage medium 925 as part of DVR database 945.Storage medium 925 may be partitioned or otherwise divided (such as into folders) such that predefined amounts of storage medium 925 are devoted to storage of television programs recorded due to user-defined timers and stored television programs recorded due to provider-defined timers.", "EPG database 930 may store information related to television channels and the timing of programs appearing on such television channels.", "EPG database 930 may be stored using storage medium 925, which may be a hard drive.", "Information from EPG database 930 may be used to inform users of what television channels or programs are popular and/or provide recommendations to the user.", "Information from EPG database 930 may provide the user with a visual interface displayed by a television that allows a user to browse and select television channels and/or television programs for viewing and/or recording.", "Information used to populate EPG database 930 may be received via network interface 920 and/or via satellites, such as satellite 130 of FIG.", "1 via tuners 915.For instance, updates to EPG database 930 may be received periodically via satellite.", "EPG database 930 may serve as an interface for a user to control DVR functions of receiver 900, and/or to enable viewing and/or recording of multiple television channels simultaneously.", "CC suggestion module 932 may implement various functionality into receiver 900 related to the suggestion services and methods described above.", "For example, CC suggestion module 932, may receive text data from decoder module 933, corresponding to decoded closed caption or subtitle streams included in transponder streams received by tuners 915.Further CC suggestion module 932 may perform analysis of the text data to generate keywords and word lists and to compare text data for matches with keywords in a word list.", "Additionally, CC suggestion module 932 may generate or facilitate the generation of interface elements included in a user interface generated by receiver 900 to allow population or changing keywords in a word list, or to display a match of one or more keywords or to request user input.", "For example, accessibility module 932 may directly generate interface elements display on a display device using the output interface 935.The network information table (NIT) 940 may store information used by receiver 900 to access various television channels.", "NIT 940 may be stored locally by a processor, such as tuning management processor 910-2 and/or by storage medium 925.Information used to populate NIT 940 may be received via satellite (or cable) through tuners 915, may be received via network interface 920, such as from the television service provider.", "As such, information present in NIT 940 may be periodically updated.", "In some embodiments, NIT 940 may be locally-stored by receiver 900 using storage medium 925.Generally, NIT 940 may store information about a service provider network, such as a satellite-based service provider network.", "Information that may be present in NIT 940 may include: television channel numbers, satellite identifiers (which may be used to ensure different satellites are tuned to for reception of desired television channels), frequency identifiers, transponder identifiers for various television channels, antenna identifiers (which may be used to ensure different antennas are tuned to for reception of desired television channels), radio frequency identifiers, and/or subchannel identifiers for various television channels.", "In some embodiments, NIT 940 may contain additional data or additional tables may be stored by the receiver.", "For example, while specific audio PIDs and video PIDs may not be present in NIT 940, a channel identifier may be present within NIT 940 which may be used to look up the audio PIDs and video PIDs in another table, such as a program map table (PMT).", "In some embodiments, a PID associated with the data for the PMT is indicated in a separate table, program association table (PAT), which is not illustrated in FIG.", "9.A PAT may be stored by the receiver in a similar manner to the NIT.", "For example, a PMT may store information on audio PIDs, and/or video PIDs.", "A PMT stores data on ECM (entitlement control message) PIDs for television channels that are transmitted on a transponder stream, transport stream, or digital broadcast.", "If, for a first television channel, multiple television channels are to be tuned to, NIT 940 and/or PMT 957 may indicate a second television channel that is to be tuned to when a first channel is tuned to; this may allow for switching to output of the second television channel for different commercials, for example.", "A table, such as the NIT, PAT, or PMT may store indications of PIDs that are related to supplemental audio content for individual channels or other forms of content.", "For instance, each television channel may be associated with a different supplemental audio PID.", "If supplemental audio content is to be transmitted for a given television channel, packets containing the supplemental audio are transmitted to the receiver having its associated supplemental audio content PID.", "This PID could be distinct from any of the audio programs of the television programming (e.g., the first audio program, second audio program (SAP), actual descriptive audio).", "In some embodiments, supplemental audio content is transmitted using the same transponder stream as the television channel or content to which the supplemental audio content corresponds.", "In some embodiments, a single supplemental audio PID is used to identify supplemental audio for multiple television channels, such as all the television channels on a given transponder.", "A second identifier present within the supplemental audio data may be used to distinguish for which television channel the supplemental audio data corresponds.", "PIDs may also be used to identify textual information, such as closed caption or secondary language caption information.", "Based on information in the NIT, it may be possible to determine the proper satellite and transponder to which to tune for a particular television channel, or to determine the proper antenna and frequency to which to tune to for a particular television channel.", "In some embodiments, the NIT may list a particular frequency to which to tune for a particular television channel.", "Once tuned to the proper satellite/transponder/antenna/frequency, the PMT PID may be used to retrieve a program map table that indicates the PIDs for audio and video streams of television channels transmitted by that transponder.", "While a large portion of storage space of storage medium 925 may be devoted to storage of television programming, a portion may be devoted to storage of non-audio/video data, such as EPG database 930 and other non-video/audio data 931.This “other” data may permit receiver 900 to function properly.", "In some embodiments, at least ten gigabytes are allocated to such other data.", "For example, if NIT 940 is stored by storage medium 925, it may be part of other non-video/audio data 931.Decoder module 933 may serve to convert encoded video and audio into a format suitable for output to a display device.", "For instance, decoder module 933 may receive MPEG video and audio from storage medium 925, network interface 920, or descrambling engine 965 to be output to a television.", "MPEG video and audio from storage medium 924 may have been recorded to DVR database 945 as part of a previously-recorded television program.", "Decoder module 933 may convert the MPEG video and audio into a format appropriate to be displayed by a television or other form of display device and audio into a format appropriate to be output from speakers, respectively.", "Decoder module 933 may have the ability to convert a finite number of television channel streams received from storage medium 925, network interface 920 or descrambling engine 965 simultaneously.", "For instance, each of decoders 934 within decoder module 933 may be able to only decode a single television channel at a time.", "While a television channel is being decoded by a decoder of decoders 934, the television channel is not necessarily output to a display device via television interface 935.For instance, a television channel may be decoded but not output to allow for seamless or near-seamless switching to the television channel when output is desired.", "For example, if a second television channel is to be output for presentation during commercial breaks on a first television channel, the second television channel and the first television channel may each be continuously decoded by different decoders of decoder module 933 to allow for fast switching between the channels.", "Without a television channel being continuously decoded, fast switching may be difficult due at least in part to the format in which the channel is encoded.", "For instance, for MPEG encoding, it may be necessary to first decode an I-frame before certain subsequent (or earlier) received frames may be properly decoded.", "The output of the decoder, which is provided to television interface 935, may be controlled by control processor 910-1 or some other processor.", "While decoder module 933 is illustrated as having three decoders 934 (decoder 934-1, decoder 934-2, and decoder 934-3), in other embodiments, a greater or fewer number of decoders may be present in receiver 900.As described above, text data included in a television channel may be decoded by decoder module 933 and passed to CC suggestion module 933 for implementation of the inventive aspects described herein.", "Television interface 935 may serve to output a signal to a television (or another form of display device) in a proper format for display of video and playback of audio.", "As such, television interface 935 may output one or more television channels, stored television programming from storage medium 925 (e.g., television programs from DVR database 945, television programs from on-demand programming 927 and/or information from EPG database 930) to a television for presentation.", "Digital Video Recorder (DVR) functionality may permit a television channel to be recorded for a period of time.", "DVR functionality of receiver 900 may be managed by control processor 910-1.Control processor 910-1 may coordinate the television channel, start time, and stop time of when recording of a television channel is to occur.", "DVR database 945 may store information related to the recording of television channels.", "DVR database 945 may store timers that are used by control processor 910-1 to determine when a television channel should be tuned to and its programs recorded to DVR database 945 of storage medium 925.In some embodiments, a limited amount of storage medium 925 may be devoted to DVR database 945.Timers may be set by the television service provider and/or one or more users of receiver 900.DVR database 945 may also be used to record recordings of service provider-defined television channels.", "For each day, an array of files may be created.", "For example, based on provider-defined timers, a file may be created for each recorded television channel for a day.", "For example, if four television channels are recorded from 6-10 PM on a given day, four files may be created (one for each television channel).", "Within each file, one or more television programs may be present.", "The service provider may define the television channels, the dates, and the time periods for which the television channels are recorded for the provider-defined timers.", "The provider-defined timers may be transmitted to receiver 900 via the television provider's network.", "For example, referring to satellite television distribution system 100 of FIG.", "1, in a satellite-based television service provider system, data necessary to create the provider-defined timers at receiver 150 may be received via satellite.", "It will be appreciated that accessibility systems described herein may be configured to receive and or identify provider-defined timers as interface elements, such as interface elements having a particular focus, and may generate accessible interface elements corresponding to accessible alternative versions of the provider-defined timers.", "As an example of DVR functionality of receiver 900 being used to record based on provider-defined timers, a television service provider may configure receiver 900 to record television programming on multiple, predefined television channels for a predefined period of time, on predefined dates.", "For instance, a television service provider may configure receiver 900 such that television programming may be recorded from 7 to 10 PM on NBC, ABC, CBS, and FOX on each weeknight and from 6 to 10 PM on each weekend night on the same channels.", "These channels may be transmitted as part of a single transponder stream such that only a single tuner needs to be used to receive the television channels.", "Packets for such television channels may be interspersed and may be received and recorded to a file.", "If a television program is selected for recording by a user and is also specified for recording by the television service provider, the user selection may serve as an indication to save the television program for an extended time (beyond the time which the predefined recording would otherwise be saved).", "Television programming recorded based on provider-defined timers may be stored to a portion of storage medium 925 for provider-managed television programming storage.", "On-demand programming 927 may represent additional television programming stored by storage medium 925.On-demand programming 927 may include television programming that was not recorded to storage medium 925 via a timer (either user- or provider-defined).", "Rather, on-demand programming is programming provided to the receiver directly for storage by the receiver and for later presentation to one or more users.", "On-demand programming 927 may not be user-selected.", "As such, the television programming stored to on-demand programming storage 927 may be the same for each receiver of a television service provider.", "User interface 950 may include a remote control (physically separate from receiver 900) and/or one or more buttons on receiver 900 that allow a user to interact with receiver 900.User interface 950 may be used to select a television channel for viewing, view information from EPG database 930, and/or program a timer stored to DVR database 945, wherein the timer is used to control the DVR functionality of control processor 910-1.User interface 950 may also be used to transmit commands to receiver 900.Referring back to tuners 915, television channels received via satellite (or cable) may contain at least some scrambled data.", "Packets of audio and video may be scrambled to prevent unauthorized users (e.g., nonsubscribers) from receiving television programming without paying the television service provider.", "When a tuner of tuners 915 is receiving data from a particular transponder of a satellite, the transponder stream may be a series of data packets corresponding to multiple television channels.", "Each data packet may contain a packet identifier (PID), which, in combination with NIT 940 and/or PMT 957, may be determined to be associated with a particular television channel.", "Particular data packets, referred to as entitlement control messages (ECMs), may be periodically transmitted.", "ECMs may be associated with another PID and may be encrypted; receiver 900 may use decryption device 960 to decrypt ECMs.", "Decryption of an ECM may only be possible if the user has authorization to access the particular television channel associated with the ECM.", "When an ECM is determined to correspond to a television channel being stored and/or displayed, the ECM may be provided to decryption device 960 for decryption.", "Decryption device 960 may be a removable or non-removable smart card.", "When decryption device 960 receives an encrypted ECM, decryption device 960 may decrypt the ECM to obtain some number of control words.", "In some embodiments, from each ECM received by decryption device 960, two control words are obtained.", "In some embodiments, when decryption device 960 receives an ECM, it compares the ECM to the previously received ECM.", "If the two ECMs match, the second ECM is not decrypted because the same control words would be obtained.", "In other embodiments, each ECM received by decryption device 960 is decrypted; however, if a second ECM matches a first ECM, the outputted control words will match; thus, effectively, the second ECM does not affect the control words output by decryption device 960.Decryption device 960 may be permanently part of receiver 900 or may be configured to be inserted and removed from receiver 900.In some embodiments, control processor 910-1, tuning management processor 910-2, or other hardware may be able to determine that a received ECM has not changed from the previous iteration, and therefore not provide the repeated ECM to the smart card, since the same control word(s) will be obtained.", "Tuning management processor 910-2 may be in communication with tuners 915 and control processor 910-1.Tuning management processor 910-2 may be configured to receive commands from control processor 910-1.Such commands may indicate when to start/stop recording a television channel and/or when to start/stop causing a television channel to be output to a television.", "Tuning management processor 910-2 may control tuners 915.From tuners 915, tuning management processor 910-2 may receive transponder streams of packetized data.", "From network interface 920, tuning management processor 910-2 may receive network transport stream of packetized data.", "As previously detailed, some or all of these packets may include a PID that identifies the content of the packet.", "Tuning management processor 910-2 may be configured to create one or more PID filters 955 that sort packets received from tuners 915 and/or network interface 920 based on the PIDs.", "When a tuner is initially tuned to a particular frequency (e.g., to a particular transponder of a satellite), a PID filter may be created based on the PMT data.", "The PID created, based on the PMT data packets, may be known because it is stored as part of NIT 940 or another table, such as a program association table (PAT).", "From the PMT data packets, PMT may be constructed by tuning management processor 910-2.PID filters 955 may be configured to filter data packets based on PIDs.", "In some embodiments, PID filters 955 are created and executed by tuning management processor 910-2.For each television channel to be output for presentation or recorded, a separate PID filter may be configured.", "In other embodiments, separate hardware may be used to create and execute such PID filters.", "Depending on a television channel selected for recording/viewing, a PID filter may be created to filter: (1) the video packets associated with the television channel; (2) the audio packets associated with the television channel; and (3), if enabled, supplemental audio content for use in conjunction with interactive content.", "PMT 957 may store the particular assignments of PIDs for individual television channels.", "For example, if a transponder data stream includes multiple television channels, data packets corresponding to a television channel that is not desired to be stored or displayed by the user may be ignored by PID filters 955 and not routed to descrambling engine 965, decryption device 960 or control processor 910-1.As such, only data packets corresponding to the one or more television channels desired to be stored and/or displayed may be filtered and passed to either descrambling engine 965 or decryption device 960; other data packets may be ignored.", "For each television channel, a stream of video packets, a stream of audio packets (one or both of the audio programs), a stream of supplemental audio content, and/or a stream of ECM packets may be present, each stream identified by a PID.", "In some embodiments, a common ECM stream may be used for multiple television channels.", "Additional data packets corresponding to other information, such as updates to NIT 940, may be appropriately routed by PID filters 955.At a given time, one or multiple PID filters may be executed by tuning management processor 910-2.Descrambling engine 965 may use the control words output by decryption device 960 in order to descramble video and/or audio corresponding to television channels for storage and/or presentation.", "Video and/or audio data contained in the transponder data stream received by tuners 915 may be scrambled.", "Video and/or audio data may be descrambled by descrambling engine 965 using a particular control word.", "Which control word output by decryption device 960 to be used for successful descrambling may be indicated by a scramble control identifier present within the data packet containing the scrambled video or audio.", "Descrambled video and/or audio may be output by descrambling engine 965 to storage medium 925 for storage (in DVR database 945) and/or to decoder module 933 for output to a television or other presentation equipment via television interface 935.For simplicity, receiver 900 of FIG.", "9 has been reduced to a block diagram; commonly known parts, such as a power supply, have been omitted.", "Further, some routing between the various modules of receiver 900 has been illustrated.", "Such illustrations are for exemplary purposes only.", "The state of two modules not being directly or indirectly connected does not indicate the modules cannot communicate.", "Rather, connections between modules of the receiver 900 are intended only to indicate possible common data routing.", "It should be understood that the modules of receiver 900 may be combined into a fewer number of modules or divided into a greater number of modules.", "FIG.", "10 depicts an example television display environment 1000.Display environment 1000 includes a receiver 1005 that generates a user interface for output by television 1010.Receiver 1005 includes CC suggestion module 1015, which may provide data related to accessibility interface elements to accessibility system 1020 for output.", "In FIG.", "10, television 1010 displays a window 1025 that includes video, such as video corresponding to a television channel received from a cable, satellite, or over-the air broadcast system.", "Television 1010 also displays an electronic program guide (EPG) 1030, which corresponds to channel information, timing of programs, and the like, for television programs and channels that may be displayed by receiver 1005 and television 1010.As illustrated, the EPG 1030 identifies a first channel “2009,” which may correspond, for example, to a first television channel, and a second channel “2010,” which may correspond, for example, to a second television channel.", "Items in the EPG 1030 may be selectable using a user interface that may make use of a remote control or other input device to interact with EPG 1030.As illustrated, indicator 1035 may highlight, as an example program, the World Series for immediate display on television 1010, such as in window 1025.Other features may also be implemented using the interface displayed, such as selection of recording one or more television channels or programs for storage to a DVR database.", "The display interface may also include an item 1040 to access CC suggestion module set-up interface 1050, which may allow for selection of a command for the receiver to configure the CC suggestion module 1015, for example.", "As an example, selection of the command to configure the CC suggestion module 1015, may generate a “pop-up” window or other interface that allows for interaction and control over configuration or information aspects relating to CC suggestion module 1015.In the CC suggestion module configuration interface 1050 that is generated, options 1055 may be selected, activated, changed, or displayed, for example.", "Useful options 1055 may include, but are not limited to, activation, deactivation, and/or configuration of a match threshold, such as to allow for more or fewer matches to be required before a suggestion is presented to a user, activation, deactivation, or configuration of popup settings, such as to facilitate default popup options, such as default option selection and default option timing and popup location and/or size on screen, activation, deactivation, or configuration of word lists, such as to facilitate keyword input entry and editing of word lists, activation, deactivation, or configuration of a language, including a primary language and/or a secondary language, when available.", "It will be appreciated that selection of a particular language may allow the CC suggestion module to make use of primary closed captions and/or secondary language closed captions to expand the potential suggestions made to a user.", "Also included in accessibility module configuration interface 1050 may be an informational item 1060 that may provide for selection of a particular user, loading of preferences, storing of preferences.", "Accessibility module configuration interface 1050 may also include an option 1065 for activating or deactivating the CC suggestion module 1015, such as to add/or remove interface features of receiver 1005 that relate to CC suggestion module 1015.CC suggestion module configuration interface 1050 may also include an option 1070 for adding, removing, or editing users associated with CC suggestion module 1015.Receiver 1006 may be in data communication with receiver 1005, such as by way of a network connection, and CC suggestion module 1015 of receiver 1006 may forward detected matches to receiver 1005 for suggestion to a user.", "A computing device as illustrated in FIG.", "11 may be incorporated as part of the previously described computerized devices, such as a television service provider system, a television receiver, a television, a set-top box, etc.", "FIG.", "11 provides a schematic illustration of one embodiment of a computing device 1100 that may perform various steps of the methods provided by various embodiments.", "It should be noted that FIG.", "11 is meant only to provide a generalized illustration of various components, any or all of which may be utilized as appropriate.", "FIG.", "11, therefore, broadly illustrates how individual system elements may be implemented in a relatively separated or relatively more integrated manner.", "The computing device 1100 is shown comprising hardware elements that may be electrically coupled via a bus 1105 (or may otherwise be in communication).", "The hardware elements may include one or more processors 1110, including without limitation one or more general-purpose processors and/or one or more special-purpose processors (such as digital signal processing chips, graphics acceleration processors, video decoders, and/or the like); one or more input devices 1115, which may include without limitation a mouse, a touchscreen, keyboard, remote control, voice input, and/or the like; and one or more output devices 1120, which may include without limitation a display device, a printer, speaker, etc.", "The computing device 1100 may further include (and/or be in communication with) one or more non-transitory storage devices 1125, which may comprise, without limitation, local and/or network accessible storage, and/or may include, without limitation, a disk drive, a drive array, an optical storage device, a solid-state storage device, such as a solid state drive (“SSD”), random access memory (“RAM”), and/or a read-only memory (“ROM”), which may be programmable, flash-updateable and/or the like.", "Such storage devices may be configured to implement any appropriate data stores, including without limitation, various file systems, database structures, and/or the like.", "The computing device 1100 might also include a communications subsystem 1130, which may include without limitation a modem, a network card (wireless or wired), an infrared communication device, a wireless communication device, and/or a chipset (such as a Bluetooth™ device, BLE, an 802.11 device, an 802.15.4 device, a WiFi device, a WiMax device, cellular communication device, etc.", "), a G.hn device, and/or the like.", "The communications subsystem 1130 may permit data to be exchanged with a network (such as the network described below, to name one example), other computer systems, and/or any other devices described herein.", "In many embodiments, the computing device 1100 will further comprise a working memory 1135, which may include a RAM or ROM device, as described above.", "The computing device 1100 also may comprise software elements, shown as being currently located within the working memory 1135, including an operating system 1140, device drivers, executable libraries, and/or other code, such as one or more application programs 1145, which may comprise computer programs provided by various embodiments, and/or may be designed to implement methods, and/or configure systems, provided by other embodiments, as described herein.", "Merely by way of example, one or more procedures described with respect to the method(s) discussed above might be implemented as code and/or instructions executable by a computer (and/or a processor within a computer); in an aspect, then, such code and/or instructions may be used to configure and/or adapt a general purpose computer (or other device) to perform one or more operations in accordance with the described methods.", "A set of these instructions and/or code might be stored on a non-transitory computer-readable storage medium, such as the non-transitory storage device(s) 1125 described above.", "In some cases, the storage medium might be incorporated within a computer system, such as computing device 1100.In other embodiments, the storage medium might be separate from a computer system (e.g., a removable medium, such as a compact disc, or a cloud- or network-based storage system), and/or provided in an installation package, such that the storage medium may be used to program, configure, and/or adapt a general purpose computer with the instructions/code stored thereon.", "These instructions might take the form of executable code, which is executable by the computing device 1100 and/or might take the form of source and/or installable code, which, upon compilation and/or installation on the computing device 1100 (e.g., using any of a variety of generally available compilers, installation programs, compression/decompression utilities, etc.", "), then takes the form of executable code.", "It will be apparent to those skilled in the art that substantial variations may be made in accordance with specific requirements.", "For example, customized hardware might also be used, and/or particular elements might be implemented in hardware, software (including portable software, such as applets, etc.", "), or both.", "Further, connection to other computing devices such as network input/output devices may be employed.", "As mentioned above, in one aspect, some embodiments may employ a computing device (such as the computing device 1100) to perform methods in accordance with various embodiments of the invention.", "According to a set of embodiments, some or all of the procedures of such methods are performed by the computing device 1100 in response to processor 1110 executing one or more sequences of one or more instructions (which might be incorporated into the operating system 1140 and/or other code, such as an application program 1145) contained in the working memory 1135.Such instructions may be read into the working memory 1135 from another computer-readable medium, such as one or more of the non-transitory storage device(s) 1125.Merely by way of example, execution of the sequences of instructions contained in the working memory 1135 might cause the processor(s) 1110 to perform one or more procedures of the methods described herein.", "The terms “machine-readable medium,” “computer-readable storage medium” and “computer-readable medium,” as used herein, refer to any medium that participates in providing data that causes a machine to operate in a specific fashion.", "These mediums may be non-transitory.", "In an embodiment implemented using the computing device 1100, various computer-readable media might be involved in providing instructions/code to processor(s) 1110 for execution and/or might be used to store and/or carry such instructions/code.", "In many implementations, a computer-readable medium is a physical and/or tangible storage medium.", "Such a medium may take the form of a non-volatile media or volatile media.", "Non-volatile media include, for example, optical and/or magnetic disks, such as the non-transitory storage device(s) 1125.Volatile media include, without limitation, dynamic memory, such as the working memory 1135.Common forms of physical and/or tangible computer-readable media include, for example, a floppy disk, a flexible disk, hard disk, magnetic tape, or any other magnetic medium, a CD-ROM, any other optical medium, any other physical medium with patterns of marks, a RAM, a PROM, EPROM, a FLASH-EPROM, any other memory chip or cartridge, or any other medium from which a computer may read instructions and/or code.", "Network-based and cloud-based storage systems may also be useful forms of computer-readable media.", "Various forms of computer-readable media may be involved in carrying one or more sequences of one or more instructions to the processor(s) 1110 for execution.", "Merely by way of example, the instructions may initially be carried on a magnetic disk and/or optical disc of a remote computer.", "A remote computer might load the instructions into its dynamic memory and send the instructions as signals over a transmission medium to be received and/or executed by the computing device 1100.The communications subsystem 1130 (and/or components thereof) generally will receive signals, and the bus 1105 then might carry the signals (and/or the data, instructions, etc.", "carried by the signals) to the working memory 1135, from which the processor(s) 1110 retrieves and executes the instructions.", "The instructions received by the working memory 1135 may optionally be stored on a non-transitory storage device 1125 either before or after execution by the processor(s) 1110.It should further be understood that the components of computing device 1100 may be distributed across a network.", "For example, some processing may be performed in one location using a first processor while other processing may be performed by another processor remote from the first processor.", "Other components of computing device 1100 may be similarly distributed.", "As such, computing device 1100 may be interpreted as a distributed computing system that performs processing in multiple locations.", "In some instances, computing device 1100 may be interpreted as a single computing device, such as a distinct laptop, desktop computer, or the like, depending on the context.", "The methods, systems, and devices discussed above are examples.", "Various configurations may omit, substitute, or add various method steps or procedures, or system components as appropriate.", "For instance, in alternative configurations, the methods may be performed in an order different from that described, and/or various stages or steps or modules may be added, omitted, and/or combined.", "Also, features described with respect to certain configurations may be combined in various other configurations.", "Different aspects and elements of the configurations may be combined in a similar manner.", "Also, technology evolves and, thus, many of the elements are examples and do not limit the scope of the disclosure or claims.", "Specific details are given in the description to provide a thorough understanding of example configurations (including implementations).", "However, configurations may be practiced without these specific details.", "For example, well-known circuits, processes, algorithms, structures, and techniques have been shown without unnecessary detail in order to avoid obscuring the configurations.", "This description provides example configurations only, and does not limit the scope, applicability, or configurations of the claims.", "Rather, the preceding description of the configurations will provide those of skill with an enabling description for implementing described techniques.", "Various changes may be made in the function and arrangement of elements without departing from the spirit or scope of the disclosure.", "Also, configurations may be described as a process which is depicted as a flow diagram or block diagram.", "Although each may describe the operations as a sequential process, many of the operations may be performed in parallel or concurrently.", "In addition, the order of the operations may be rearranged.", "A process may have additional steps not included in the figure.", "Furthermore, examples of the methods may be implemented by hardware, software, firmware, middleware, microcode, hardware description languages, or any combination thereof.", "When implemented in software, firmware, middleware, or microcode, the program code or code segments to perform the necessary tasks may be stored in a non-transitory computer-readable medium such as a storage medium.", "Processors may perform the described tasks.", "Furthermore, the examples described herein may be implemented as logical operations in a computing device in a networked computing system environment.", "The logical operations may be implemented as: (i) a sequence of computer implemented instructions, steps, or program modules running on a computing device; and (ii) interconnected logic or hardware modules running within a computing device.", "Although the subject matter has been described in language specific to structural features and/or methodological acts, it is to be understood that the subject matter defined in the appended claims is not necessarily limited to the specific features or acts described above.", "Rather, the specific features and acts described above are disclosed as example forms of implementing the claims." ] ]
Patent_15872597
[ [ "IMPLANT COMPONENTS AND METHODS", "Systems, devices, and methods are provided for orthopedic implants.", "The implants may include a base member, such as an acetabular shell or an augment, that is configured to couple with an augment, flange cup, mounting member, or any other suitable orthopedic attachment.", "Mounting members include, for example, flanges, blades, hooks, and plates.", "In some embodiments, the orthopedic attachments may be adjustably positionable about the base member or other attachments, thereby providing modularity for assembling and implanting the device, and various securing and/or locking mechanisms may be used between the components of the implant." ], [ "1.-20.", "(canceled) 21.An orthopedic device, comprising: an acetabular implant configured to be attached to a patient's bone at a surgical site; and at least one mounting member coupled to the acetabular implant and configured to be anchored to the patient's bone at the surgical site, the mounting member including: a first portion; a second portion; and a bendable region structured such that the at least one mounting member is bendable in situ after implantation of the acetabular implant and the mounting member at the surgical site wherein the first portion is bent relative to the second portion.", "22.The orthopedic device of claim 21, wherein the acetabular implant comprises an acetabular cup; and wherein the mounting member extends from an outer surface of the acetabular cup.", "23.The orthopedic device of claim 21, wherein the acetabular implant comprises an acetabular cup and an acetabular augment; wherein the mounting member extends from an outer surface of the acetabular augment; and wherein the acetabular augment is attached to an outer surface of the acetabular cup.", "24.The orthopedic device of claim 21, wherein the mounting member comprises a flange, hook or plate.", "25.The orthopedic device of claim 21, wherein the mounting member comprises an acetabular augment and a flange or plate extending from the acetabular augment; and wherein the acetabular augment is attached to an outer surface of the acetabular implant.", "26.The orthopedic device of claim 21, wherein the bendable region comprises an area of reduced strength to facilitate bending of the first portion relative to the second portion.", "27.The orthopedic device of claim 21, wherein the bendable region comprises an area of reduced cross-sectional profile to facilitate bending of the first portion relative to the second portion.", "28.The orthopedic device of claim 27, wherein the area of reduced cross-sectional profile is defined by at least one void extending into an outer surface of the mounting member.", "29.The orthopedic device of claim 28, wherein the at least one void comprises a notch, groove, indent, cross-hatch or cutout extending into the outer surface of the mounting member.", "30.The orthopedic device of claim 28, wherein the mounting member includes an upper surface, a lower surface positionable in contact with the patient's bone, and a side surface extending between the upper surface and the lower surface; and wherein the at least one void extends across the side surface of the mounting member to provide the area of reduced cross-sectional profile.", "31.The orthopedic device of claim 28, wherein the mounting member includes an upper surface and a lower surface positionable in contact with the patient's bone; and wherein the at least one void extends across at least one of the upper or lower surface of the mounting member to provide the area of reduced cross-sectional profile.", "32.The orthopedic device of claim 28, wherein the mounting member includes an upper surface and a lower surface positionable in contact with the patient's bone; and wherein the at least one void comprises a notch or groove extending across at least one of the upper or lower surface of the mounting member to provide the area of reduced cross-sectional profile; and wherein the at least one void further comprises cross-hatching extending across the at least one of the upper or lower surface of the mounting member.", "33.The orthopedic device of claim 28, wherein the mounting member includes an upper surface and a lower surface positionable in contact with the patient's bone; and wherein at least one of the upper or lower surface of the mounting member is cross-hatched to provide the area of reduced cross-sectional profile.", "34.The orthopedic device of claim 28, wherein the at least one void comprises a notch, groove extending into the outer surface of the mounting member, the notch or groove having a semi-circular shape or V-shape.", "35.The orthopedic device of claim 28, wherein the mounting member defines at least one opening extending therethrough and having an internal geometry sized to receive a fastener for anchoring within the patient's bone to secure the mounting member to the patient's bone; and wherein the at least one void is structured to facilitate bending of the first portion relative to the second portion without disturbing or changing the internal geometry of the at least one opening.", "36.The orthopedic device of claim 21, wherein the mounting member defines at least one opening extending therethrough and having an internal geometry sized to receive a fastener for anchoring within the patient's bone to secure the mounting member to the patient's bone; and wherein the bendable region is structured to facilitate bending of the first portion relative to the second portion without disturbing or changing the internal geometry of the at least one opening.", "37.The orthopedic device of claim 36, wherein the mounting member defines a plurality of the at least one opening extending therethrough; and wherein the bendable region is positioned between an adjacent pair of the plurality of openings.", "38.The orthopedic device of claim 21, wherein the mounting member includes a porous outer surface positionable in contact with the patient's bone to facilitate bone in-growth into the porous outer surface.", "39.The orthopedic device of claim 38, wherein the mounting member includes a plurality of porous areas positionable in contact with the patient's bone to facilitate bone in-growth into the porous out surface; and wherein adjacent ones of the plurality of porous areas are separated by a corresponding one of the bendable region.", "40.An orthopedic device, comprising: an acetabular cup configured to be attached to a patient's bone at a surgical site; and an acetabular flange coupled to the acetabular cup and configured to be anchored to the patient's bone at the surgical site, the acetabular flange including: a first portion; a second portion; and a bendable region comprising an area of reduced cross-sectional profile to facilitate in situ bending of the first portion relative to the second portion after implantation of the acetabular cup and the acetabular flange at the surgical site, wherein the area of reduced cross-sectional profile is defined by at least one notch or groove extending into an outer surface of the acetabular flange.", "41.The orthopedic device of claim 40, wherein the acetabular flange includes an upper surface, a lower surface positionable in contact with the patient's bone, and a side surface extending between the upper surface and the lower surface; and wherein the at least one notch or groove extends across the side surface of the acetabular flange to provide the area of reduced cross-sectional profile.", "42.The orthopedic device of claim 40, wherein the acetabular flange includes an upper surface and a lower surface positionable in contact with the patient's bone; and wherein the at least one notch or groove extends across at least one of the upper or lower surface of the acetabular flange to provide the area of reduced cross-sectional profile.", "43.The orthopedic device of claim 40, wherein the acetabular flange defines at least one opening extending therethrough and having an internal geometry sized to receive a fastener for anchoring within the patient's bone to secure the acetabular flange to the patient's bone; and wherein the area of reduced cross-sectional profile is structured to facilitate bending of the first portion relative to the second portion without disturbing or changing the internal geometry of the at least one opening.", "44.A method of implanting the orthopedic device of claim 21, the method comprising: inserting the acetabular implant to the surgical site and attaching the acetabular implant to the patient's bone; after the inserting, bending the bendable region of the at least one mounting member in situ at the surgical site wherein the first portion is bent relative to the second portion; and after the bending, anchoring the at least one mounting member to the patient's bone.", "45.The method of claim 44, wherein the anchoring comprises inserting one or fasteners through one or more corresponding openings extending through the at least one mounting member; wherein the bendable region of the at least one mounting member is positioned between an adjacent pair of the one or more openings; and wherein the bending of the bendable region does not disturb or change an internal geometry of the openings." ], [ "<SOH> BACKGROUND <EOH>Joints often undergo degenerative changes due to a variety of reasons.", "When joint degeneration becomes advanced or irreversible, it may become necessary to replace the natural joint with a prosthetic joint.", "Artificial implants, including hip joints, shoulder joints, and knee joints are widely used in orthopedic surgery.", "Specifically, hip joint prostheses are common.", "The human hip joint acts mechanically as a ball and socket joint, wherein the ball-shaped head of the femur is positioned within the socket-shaped acetabulum of the pelvis.", "Various degenerative diseases and injuries may require replacement of all or a portion of a hip using synthetic materials, typically metals, ceramics, or plastics.", "More particularly, natural hips often undergo degenerative changes, requiring replacement of the hip joint with a prosthetic joint.", "Often, the hip is replaced with two bearing surfaces between the femoral head and the acetabulum.", "The first bearing surface is typically a prosthesis shell or acetabular cup, which may be formed of metal, ceramic material, or as otherwise desired.", "A liner (conventionally formed of polyethylene material such as ultra high molecular weight polyethylene, a ceramic material, or in some cases, even a metal liner) is then fit tightly within the shell to provide an inner bearing surface that receives and cooperates with an artificial femoral head in an articulating relationship to track and accommodate the relative movement between the femur and the acetabulum.", "The cup (or a cup and liner assembly) is typically fixed either by placing screws through apertures in the cup or by securing the cup with cement.", "In some cases, only a liner is cemented in a patient due to poor bone stock.", "In other cases, a cup having a porous surface may be press fit into the reamed acetabular surface.", "It may become necessary to conduct a second or subsequent surgery in order to replace a prosthetic joint with a (often larger) replacement joint.", "Such surgeries often become necessary due to further degeneration of bone or advancement of a degenerative disease, requiring removal of further bone and replacement of the removed, diseased bone with a larger or enhanced prosthetic joint, often referred to as a revision prosthesis.", "For example, bone is often lost around the rim of the acetabulum, and this may provide less rim coverage to securely place a press-fit cup.", "Such surgeries may thus be referred to as revision surgeries.", "In acetabular revision surgery, an acetabular prosthesis generally includes additional mounting elements, such as augments, flanges, hooks, plates, or any other attachment or mounting points or members that provide additional support and/or stability for the replacement prosthesis once positioned.", "These additional mounting or attachment members are often required due to bone degeneration, bone loss, or bone defects in the affected area (in this instance, the hip joint).", "Various types of these mounting members (which term is intended to include but not be limited to flanges, blades, plates and/or hooks) may be provided in conjunction with a prosthesis system in order to help the surgeon achieve optimal fixation, non-limiting examples of which include iliac flanges (providing securement and fixation in and against the ilium region of the pelvis), ischial blades (providing securement and fixation in and against the ischium), and obturator hooks (providing securement and inferior fixation by engaging the obturator foramen).", "Although there have been attempts to provide such mounting attachments with modularity, the solutions to date have generally fallen short of providing true modularity.", "Instead, they typically provide a few discrete positions at which the mounting members may be positioned, without providing the surgeon a fuller range of decision options.", "Additionally, in some primary surgeries and more often in revision surgeries, the acetabulum may have a bone defect or void that the surgeon must fill with bone grafts before inserting a new shell.", "This can be time consuming and expensive, and may subject the patient to additional health risks.", "Some techniques use an augment in connection with the acetabular shell, which can be coupled to or otherwise attached to the outer surface of the shell.", "With current augments, the surgeon can attach the augment to the bone and then implant the cup.", "However, many acetabular shells rely on bone screws to achieve proper fixation and the augment often gets in the way of a screw.", "In short, surgeons need the freedom to place screws in the best location, but this compromises their ability to use augments.", "With current systems, it also takes an increased amount of time surgical time to trial the component orientation and then try to find good bone fixation for the cup.", "The surgeon will often have to free-hand the amount of bone removed while estimating the size of augment needed.", "In the cases where bone is often deficient, surgeons are hesitant to take away any more bone than necessary.", "Various additional features and improved features intended for use and application with various types of joint implants are also described herein, such as improved bone screws, improved coatings, and various augment removal and insertion options." ], [ "<SOH> SUMMARY <EOH>Disclosed herein are systems, devices, and methods for providing modular orthopedic implants.", "The implants may include a base member, such as an acetabular shell or an augment, that is configured to couple with an augment, flange cup, mounting member, any other suitable orthopedic attachment, or any combinations thereof.", "Mounting members include, for example, flanges, blades, hooks, and plates.", "In some embodiments, the orthopedic attachments may be adjustably positionable about the base member or other attachments thereby providing modularity for assembling and implanting the device.", "Various securing and/or locking mechanisms may be used between the components of the implant.", "In certain embodiments, the orthopedic attachments are removably coupled to the base member or other components.", "In certain embodiments, the orthopedic attachments are integrally provided on the base member or other components, yet may still be adjustably positionable thereabout.", "In some embodiments, expandable augments, base members, or other bone filling devices are provided.", "In some embodiments, surface features are provided that create friction and allow for surrounding bone ingrowth at the interface of the implants and a patient's bone.", "Systems, devices, and methods described herein provide implants having attachment mechanisms that provide a plurality of positioning options for the orthopedic attachments.", "In certain embodiments, an orthopedic device includes an implant structured to fit with and stabilize a patient's orthopedic joint, the implant having a plurality of attachment sites, and a mounting member having a first end that anchors to the patient's bone or soft tissue and a second end that mates with the implant at each of the plurality of attachment sites.", "The plurality of attachment sites can include portions of a crossbar extending about an acetabular shell.", "Alternatively or additionally, the attachment sites can include a groove extending along a rim of the implant.", "In some embodiments, attached mounting members may include conventional holes, locking holes, or slots.", "The sites may be threaded, unthreaded, or partially threaded, and may be fixed or polyaxial.", "In some embodiments, attachment sites may include variable low-profile holes that allow for locking at a variety of angles.", "In some embodiments, a porous surface is disposed on a portion of the mounting member.", "In some embodiments, the mounting member is a flange that is adjustably positionable about the circumference of an acetabular implant.", "For example, the flange (or any other suitable mounting member) can pivot in a plane that is perpendicular to the circumference of an acetabular shell.", "The flange can include a split eye-let and/or a hook that joins a rail or groove on the implant.", "The flange can also include a key that removably inserts within a complementary rim on an acetabular shell.", "In certain embodiments, the flange is a flexible strap, or the flange may include a frangible portion that allows the flange to bend or break.", "In certain embodiments, the implant includes an annular recessed slot with an overhanging lip, where the mounting member includes a distal portion that fits within the annular recessed slot.", "The implant can be an augment that mounts to a surgical shell or cage, and the implant can fit within one of a shoulder, hip, or ankle joint.", "In certain embodiments, the mounting member includes a plurality of flanges, at least one flange being adjustably positionable with respect to more than one of the attachment sites.", "In certain embodiments, a method of installing an orthopedic implant within a patient includes the steps of inserting the implant into the patient, selecting a site along the inserted implant to receive a first mounting member, attaching the first mounting member to the selected site, and anchoring the first mounting member to the patient.", "The selected site may be chosen from a plurality of attachment sites that are angularly spaced about the implant.", "The method may further include the step of applying a porous surface to a portion of the first mounting member.", "In some embodiments, the inserting step may include the step of mounting an acetabular shell or cage within the patient's acetabulum.", "In some embodiments, the implant may be an acetabular augment, and the inserting step may include the step of mounting the acetabular augment to an acetabular shell.", "The method may further include the step of detaching a detachable portion of the first mounting member after attaching the first mounting member to the selected site.", "In some embodiments, the anchoring step includes the step of anchoring the first mounting member to a first entry point within the selected site.", "The method may further include the step of cementing the implant into the patient's acetabulum prior to attaching the first mounting member to the selected site.", "The method may further include the step of adjustably positioning the mounting member about the circumference of the implant and along the selected site.", "In some embodiments, the mounting member may include a flange, hook, or plate.", "In certain embodiments, mounting members or augments shown and described in the figures contained herein may comprise tacks, spikes, coatings, or textured surfaces so as to improve initial fixation.", "The geographic locations of tacks, spikes, coatings, or textured surface structures may be strategically placed on select portions of a mounting member or implant so as to evenly load the mounting member or implant assembly and obtain the best biologic response initially, and over an extended period of time.", "Systems, devices, and methods described herein provide implants that can include a flange cup.", "In certain embodiments, an acetabular implant system includes an acetabular shell, a cup member that fits positionably within the acetabular shell, and at least one mounting member coupled to the cup member, where the at least one mounting member has a first portion that is attachable to a patient's bone to thereby anchor to the patient's bone.", "The mounting member may include a flange that is adjustably positionable about the cup member and has a first end with an attachment portion that anchors to the patient's bone.", "In some embodiments, the cup member includes a distal tapered end that locks to an attachment site within the acetabular shell.", "In some embodiments, the attachment site within the acetabular shell is further configured to receive a liner.", "In some embodiments, the system includes a liner disposed within the cup member.", "The cup member may be configured as a band or as a full cup such that the liner is fully supported within the cup member.", "The at least one mounting member may include a flange, hook, or plate, and the at least one mounting member may be removably attached to the cup member.", "Alternatively, the at least one mounting member is integrally provided on the cup member.", "In certain embodiments, a method of forming a surgical implant includes inserting an implant within a patient's acetabulum, providing a cup member, having at least one mounting member, within the inserted implant, aligning the cup member with the implant so that the at least one mounting member aligns with a patient bone site, and attaching the at least one mounting member to the patient's bone.", "The method may also include adjustably positioning the at least one mounting member about the cup member, wherein the at least one mounting member has a first end with an attachment portion that anchors to the patient's bone, locking a distal tapered end of the cup member to an attachment site within the implant, and disposing a liner within the attachment site.", "In some embodiments, the method may further include disposing a liner within the cup member, where the cup member is provided as band or a full cup such that the liner is fully supported within the cup member.", "The at least one mounting member may include a flange, hook, or plate, and the method may further include removably attaching the at least one mounting member to the cup member.", "Alternatively, the at least one mounting member may be integrally provided on the cup member.", "Systems, devices, and methods described herein provide implants having augments configured to attach to acetabular shells or cages, mounting members, or other augments with or without cement and configured to allow fine positional adjustments for best bone fit, coverage, and stability.", "In certain embodiments, an orthopedic implant includes an acetabular implant having a track that includes a plurality of slots and an exterior surface, an augment having a protrusion that moves within the plurality of slots, the augment having a first cam surface that forms an interface with the exterior surface, where the protrusion has an adjustable fastener that, upon adjusting, fixes the augment with respect to the implant to impede further movement.", "In some embodiment, the augment may rotate about the exterior surface.", "The adjustable fastener may be a tightening screw that extends through a through-hole in the augment and, upon tightening, expands the protrusion (which may be flared outwardly) and thereby tightens the augment within the track.", "In some embodiments, the tightening screw has a head that fits within a slot and faces an interior portion of the implant, where the slot has an interior opening that aligns with the head, and where the interior opening receives a tightening rod to tighten the screw.", "In some embodiments, the track includes a dovetail joint that receives the protrusion.", "In some embodiments, the track includes a straight portion and a curved portion.", "For example, the track can include two straight slots and a curved portion.", "In some embodiments, the track includes a J-shaped slot with a wall of the implant.", "The protrusion may be part of an intermediate locking member that is integral to the augment.", "In some embodiments, the first cam surface of the augment includes at least one trough that receives cement to bind the augment to the shell.", "In some embodiments, the augment includes a plurality of projections that form a gap and may further include a flange attached to the augment.", "In certain embodiments, a method of preparing an orthopedic implant includes the steps of providing an implant having a curved external surface and an opening in the surface, the opening having at least two portions that join at a common region but are separated by an angle of less than 180°, providing an augment having a first surface that interfaces with the curved external surface, coupling the augment and implant by an intermediate locking member, and tightening the intermediate locking member.", "In some embodiments, the method may further include the step of securing the augment to the implant by disposing cement within a trough located on the first surface.", "In some embodiments, the method may further include the step of rotating the augment with respect to the implant about the curved external surface prior to tightening the intermediate locking member, and moving the intermediate locking member within the opening prior to tightening.", "In some embodiments, the method may further include the steps of applying a fastener to the implant, so that the fastener extends outwardly from the external surface, and positioning the augment about the external surface so that the extended fastener fits between two protrusions of the augment, where the intermediate locking member is tightened with respect to the augment by a screw.", "Systems, devices, and methods described herein provide implants that create friction and allow for surrounding bone ingrowth at the interface of the implants and a patient's bone.", "In certain embodiments, an implantable orthopedic device includes an implant that has a surface that contacts a patient's joint and has a plurality of protrusions connected to the surface that rise above the surface.", "The implant may also include pores dispersed throughout the surface at the bone interface.", "The protrusions located at the surface of the implant may be blunt, or may be any other suitable shape and configuration.", "The protrusions may extend from the surface to any suitable height, such as heights between about 50 μm and about 2000 μm, heights between about 100 μm and 1100 μm, or heights between about 200 μm and 400 μm.", "The protrusions may be spaced on the surface of the implant in any suitable concentration or density.", "The desired protrusion density may also be patient-specific, and may be determined based on the density of a native bone into which a component is implanted.", "An implant may have a large number of protrusion features on its surface, and one or more of these individual features may fall outside of a desired size or spacing without affecting the overall efficacy of the surface.", "In certain embodiments, an implant includes internal or external strengthening features.", "A porous implant may include internal or external strengthening ribs to provide support to surrounding porous structures.", "A porous implant may also be coupled with a flange that has a first end for attaching the flange to the implant and a second end for attaching the flange to surrounding bone structure.", "The porous implant may also include a reticulated surface coating.", "In certain embodiments, an implantable orthopedic device is created by providing a mold having a negative impression of a porous beaded surface and providing an implant substrate to be coated.", "Particles are interposed between the implant substrate and the mold, and a pressure or elevated temperature may be applied to the mold, implant substrate, and particles.", "The implant substrate provided may be solid or may be porous, and the particles interposed between the implant substrate and the mold may be symmetric or asymmetric.", "In certain embodiments, an implantable orthopedic device is created by creating a three-dimensional model simulating an outer surface profile of a porous beaded implant and creating a three-dimensional model of an implant substrate volume.", "The model simulating an outer surface profile of a porous beaded implant is applied to the model of an implant substrate volume to create a pre-form volume, and an algorithm is applied to fill the pre-form volume with a desired reticulated structure to create a porous implant model.", "An implant is formed using the porous implant model.", "In certain embodiments, an implantable orthopedic device is created by providing a mold of an implant having an inner surface mimicking a negative image of an outer surface profile geometry of a porous beaded surface and providing a plurality of particles that are placed into the mold.", "Pressure or elevated temperature is applied to the mold and particles.", "The particles placed into the mold may be symmetric or asymmetric.", "In certain embodiments, an implantable orthopedic device is created by providing a mold of an implant having an inner surface mimicking a negative image of an outer surface profile geometry of a porous beaded surface and loading one or more foaming agents into the mold.", "A porous foam component is created in the general shape or size of the implant that has an outer surface geometry mimicking an outer surface profile geometry of a porous beaded surface.", "The porous foam component is removed from the mold, and a binding agent is applied to the porous foam component.", "A plurality of symmetric or asymmetric particles are applied to the porous foam component having the binding agent and the porous foam component, binding agent, and particles are subjected to an elevated temperature to sinter the particles together and burn out the foam component to form an implant having a roughened porous texture with an outer surface profile geometry mimicking a clinically-proven porous beaded structure.", "The porous foam component may be polymeric, and may be a polyurethane component.", "Systems, devices, and methods described herein provide implants that can be expanded or adjusted to fill bone voids in a patient's anatomy surrounding the implant.", "In certain embodiments, an orthopedic implant includes an acetabular implant with first and second portions that are separated along a side of the implant by a slit and an expansion member disposed between the first and second portions and adjustable by a tightening tool to displace the two portions relative to each other.", "The implant may also include a hinge that joins the first and second portions along a side of the implant.", "The first and second portions of an implant may comprise a solid portion, and the volume of the implant not including the solid portion may be porous.", "Any number of portions may be provided in the implant, and the implant may have any number of intersecting perpendicular slits for dividing the portions.", "The implant may be a flange connected to an acetabular shell, or may be an acetabular shell or cage.", "The implant may include a screw that passes through the implant to connect the implant to a patient's acetabulum.", "In certain embodiments, an expansion member used in an expandable or adjustable implant may be a shaped memory plug or a screw.", "The expansion member may be an augment with a curved side and a connection site that attaches to an acetabular shell.", "In certain embodiments, an orthopedic device is implanted in a patient's joint by installing an acetabular shell or cage within the joint and placing an augment between the shell and the patient's bone.", "Two portions of the augment are expanded until a first portion abuts the patient's bone and a second bone abuts the acetabular shell or cage, and the augment is anchored to the bone.", "The portions of the augment may be expanded using a tightening tool coupled to an expansion member disposed between the portions of the augment to displace the portions relative to each other.", "The expansion member used may be a shaped memory plug, a screw, or a wedge, and the tightening tool may include a torque-limiting device.", "The two portions of the augment may be expanded along a hinge that joins the portions.", "The portions of the augment may be biased towards one another.", "A screw may be passed through the shell to connect the shell to the patient's acetabulum.", "A porous surface may be applied to a portion of the augment.", "The augment may be removed via slits or flexible hinge portions provided on the augment.", "Systems, devices, and methods described herein provide implants having a plurality of projections and optional fixation elements.", "In certain embodiments, an orthopedic augment includes a base member to which at least two projections are coupled, the at least two projections having a gap therebetween, and a fixation element provided on one or more of the at least two projections.", "The fixation element may be a cement trough.", "In certain embodiments, the base member is shaped to couple with an implant.", "For example, a first surface of the base member that contacts the implant may be substantially arcuate.", "The at least two projections may be disposed in substantially the same direction.", "The length of the at least two projections may be substantially the same, or the length of one of the at least two projections may be different than the respective length of another of the at least two projections.", "In some embodiments, the base member includes one or more fixation elements such as screw holes configured to receive a fastener.", "In some embodiments, the base member includes a connection element configured to receive a driver handle for placing the orthopedic augment into a patient's joint.", "In some embodiments, the base member includes timing marks configured to align with corresponding timing marks on an implant.", "In some embodiments, the augment may further include flanges, blades, plates, or hooks attached thereto.", "In certain embodiments, a method of implanting an orthopedic device in a patient's joint may include placing an implant within the patient's joint, the implant secured to the joint via a fixation device, preparing a space in the patient's bone proximate the implant and the fixation device, providing an augment that includes at least two projections having a gap therebetween, and inserting the augment into the prepared space by positioning the augment around the fixation member such that the fixation member extends through the gap between the at least two projections of the augment.", "The method may further include forming a cement trough on one or more of the at least two projections, and setting the augment by pouring cement into the cement trough.", "In some embodiments, the method includes setting the augment using screws.", "The preparing may include rasping or reaming the patient's bone with a broach.", "The broach may have approximately the same cross-sectional profile as the augment.", "In some embodiments, the amount of bone removed may be limited by using a depth stop disposed on the broach.", "The inserting may include attaching the augment to a driver handle for positioning the augment into the prepared space.", "The method may further include aligning timing marks disposed on the augment with timing marks disposed on the implant.", "In some embodiments, the augment further comprises flanges, blades, plates, or hooks attached thereto.", "In some embodiments, the placing includes mounting an acetabular shell or cage within the patient's acetabulum.", "Systems, devices, and methods described herein provide modular orthopedic implants.", "In certain embodiments, an orthopedic device includes an implant having a plurality of attachment sites and a track that includes a plurality of slots, a mounting member having a first end that anchors to a patient's bone or soft tissue and a second end that mates with the implant at each of the plurality of attachment sites, and an augment having a protrusion that translates within the plurality of slots, the augment having a first cam surface that forms an interface with an exterior surface of the implant and rotates about that exterior surface.", "In some embodiments, the mounting member may be a flange, hook, or plate that may be adjustably positionable about the circumference of an acetabular implant.", "The flange, hook, or plate may pivot in a plane that is perpendicular to the circumference of an acetabular shell.", "In some embodiments, the mounting member is an acetabular augment that includes a base member to which at least two projections are coupled, the at least two projections having a gap therebetween.", "A cement trough may be provided on one or more of the at least two projections.", "In some embodiments, the orthopedic device further includes a cup member disposed within the implant, the cup member having one or more mounting members that are attachable to a patient's bone to thereby anchor to the patient's bone.", "The cup member may be a flange cup having one or more flanges attached thereto, and there may be a liner disposed within the cup member.", "In some embodiments, the protrusion has an adjustable fastener that, upon adjusting, fixes the augment with respect to the implant to impede further translation and rotation.", "In some embodiments, a porous surface is disposed on at least one of the implant, mounting member, and augment.", "The porous surface may include a plurality of protrusions that connect to the porous surface and rise above the porous surface and a plurality of pores dispersed within the porous surface.", "In some embodiments, the augment or the implant (or both) includes a first portion and a second portion, the first and second portions being separated along a first side of the augment by a slit, and an expansion member disposed between the first and second portions, the expansion member being adjustable by a tightening tool to displace the two portions relative to each other.", "In certain embodiments, an orthopedic implant includes an implant having a plurality of attachment means and a track that includes positioning means, a mounting member having a first end that anchors to a patient's bone or soft tissue and a second end that mates with the implant at each of the plurality of attachment means; and an augment having a protrusion that translates within the positioning means, the augment having a first cam surface that forms an interface with an exterior surface of the implant and rotates about that exterior surface.", "In some embodiments, the mounting member may be a flange, hook, or plate that may be adjustably positionable about the circumference of an acetabular implant.", "In some embodiments, the mounting member is an acetabular augment that includes a base member to which at least two projections are coupled, the at least two projections having a gap therebetween." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application claims the benefit of U.S.", "Provisional Patent Application No.", "61/352,705, filed Jun.", "8, 2010, U.S.", "Provisional Application No.", "61/352,722, filed Jun.", "8, 2010, U.S.", "Provisional Application No.", "61/422,903, filed Dec. 14, 2010, and U.S.", "Provisional Application No.", "61/466,817, filed Mar.", "23, 2011, which are hereby incorporated by reference herein in their entireties.", "BACKGROUND Joints often undergo degenerative changes due to a variety of reasons.", "When joint degeneration becomes advanced or irreversible, it may become necessary to replace the natural joint with a prosthetic joint.", "Artificial implants, including hip joints, shoulder joints, and knee joints are widely used in orthopedic surgery.", "Specifically, hip joint prostheses are common.", "The human hip joint acts mechanically as a ball and socket joint, wherein the ball-shaped head of the femur is positioned within the socket-shaped acetabulum of the pelvis.", "Various degenerative diseases and injuries may require replacement of all or a portion of a hip using synthetic materials, typically metals, ceramics, or plastics.", "More particularly, natural hips often undergo degenerative changes, requiring replacement of the hip joint with a prosthetic joint.", "Often, the hip is replaced with two bearing surfaces between the femoral head and the acetabulum.", "The first bearing surface is typically a prosthesis shell or acetabular cup, which may be formed of metal, ceramic material, or as otherwise desired.", "A liner (conventionally formed of polyethylene material such as ultra high molecular weight polyethylene, a ceramic material, or in some cases, even a metal liner) is then fit tightly within the shell to provide an inner bearing surface that receives and cooperates with an artificial femoral head in an articulating relationship to track and accommodate the relative movement between the femur and the acetabulum.", "The cup (or a cup and liner assembly) is typically fixed either by placing screws through apertures in the cup or by securing the cup with cement.", "In some cases, only a liner is cemented in a patient due to poor bone stock.", "In other cases, a cup having a porous surface may be press fit into the reamed acetabular surface.", "It may become necessary to conduct a second or subsequent surgery in order to replace a prosthetic joint with a (often larger) replacement joint.", "Such surgeries often become necessary due to further degeneration of bone or advancement of a degenerative disease, requiring removal of further bone and replacement of the removed, diseased bone with a larger or enhanced prosthetic joint, often referred to as a revision prosthesis.", "For example, bone is often lost around the rim of the acetabulum, and this may provide less rim coverage to securely place a press-fit cup.", "Such surgeries may thus be referred to as revision surgeries.", "In acetabular revision surgery, an acetabular prosthesis generally includes additional mounting elements, such as augments, flanges, hooks, plates, or any other attachment or mounting points or members that provide additional support and/or stability for the replacement prosthesis once positioned.", "These additional mounting or attachment members are often required due to bone degeneration, bone loss, or bone defects in the affected area (in this instance, the hip joint).", "Various types of these mounting members (which term is intended to include but not be limited to flanges, blades, plates and/or hooks) may be provided in conjunction with a prosthesis system in order to help the surgeon achieve optimal fixation, non-limiting examples of which include iliac flanges (providing securement and fixation in and against the ilium region of the pelvis), ischial blades (providing securement and fixation in and against the ischium), and obturator hooks (providing securement and inferior fixation by engaging the obturator foramen).", "Although there have been attempts to provide such mounting attachments with modularity, the solutions to date have generally fallen short of providing true modularity.", "Instead, they typically provide a few discrete positions at which the mounting members may be positioned, without providing the surgeon a fuller range of decision options.", "Additionally, in some primary surgeries and more often in revision surgeries, the acetabulum may have a bone defect or void that the surgeon must fill with bone grafts before inserting a new shell.", "This can be time consuming and expensive, and may subject the patient to additional health risks.", "Some techniques use an augment in connection with the acetabular shell, which can be coupled to or otherwise attached to the outer surface of the shell.", "With current augments, the surgeon can attach the augment to the bone and then implant the cup.", "However, many acetabular shells rely on bone screws to achieve proper fixation and the augment often gets in the way of a screw.", "In short, surgeons need the freedom to place screws in the best location, but this compromises their ability to use augments.", "With current systems, it also takes an increased amount of time surgical time to trial the component orientation and then try to find good bone fixation for the cup.", "The surgeon will often have to free-hand the amount of bone removed while estimating the size of augment needed.", "In the cases where bone is often deficient, surgeons are hesitant to take away any more bone than necessary.", "Various additional features and improved features intended for use and application with various types of joint implants are also described herein, such as improved bone screws, improved coatings, and various augment removal and insertion options.", "SUMMARY Disclosed herein are systems, devices, and methods for providing modular orthopedic implants.", "The implants may include a base member, such as an acetabular shell or an augment, that is configured to couple with an augment, flange cup, mounting member, any other suitable orthopedic attachment, or any combinations thereof.", "Mounting members include, for example, flanges, blades, hooks, and plates.", "In some embodiments, the orthopedic attachments may be adjustably positionable about the base member or other attachments thereby providing modularity for assembling and implanting the device.", "Various securing and/or locking mechanisms may be used between the components of the implant.", "In certain embodiments, the orthopedic attachments are removably coupled to the base member or other components.", "In certain embodiments, the orthopedic attachments are integrally provided on the base member or other components, yet may still be adjustably positionable thereabout.", "In some embodiments, expandable augments, base members, or other bone filling devices are provided.", "In some embodiments, surface features are provided that create friction and allow for surrounding bone ingrowth at the interface of the implants and a patient's bone.", "Systems, devices, and methods described herein provide implants having attachment mechanisms that provide a plurality of positioning options for the orthopedic attachments.", "In certain embodiments, an orthopedic device includes an implant structured to fit with and stabilize a patient's orthopedic joint, the implant having a plurality of attachment sites, and a mounting member having a first end that anchors to the patient's bone or soft tissue and a second end that mates with the implant at each of the plurality of attachment sites.", "The plurality of attachment sites can include portions of a crossbar extending about an acetabular shell.", "Alternatively or additionally, the attachment sites can include a groove extending along a rim of the implant.", "In some embodiments, attached mounting members may include conventional holes, locking holes, or slots.", "The sites may be threaded, unthreaded, or partially threaded, and may be fixed or polyaxial.", "In some embodiments, attachment sites may include variable low-profile holes that allow for locking at a variety of angles.", "In some embodiments, a porous surface is disposed on a portion of the mounting member.", "In some embodiments, the mounting member is a flange that is adjustably positionable about the circumference of an acetabular implant.", "For example, the flange (or any other suitable mounting member) can pivot in a plane that is perpendicular to the circumference of an acetabular shell.", "The flange can include a split eye-let and/or a hook that joins a rail or groove on the implant.", "The flange can also include a key that removably inserts within a complementary rim on an acetabular shell.", "In certain embodiments, the flange is a flexible strap, or the flange may include a frangible portion that allows the flange to bend or break.", "In certain embodiments, the implant includes an annular recessed slot with an overhanging lip, where the mounting member includes a distal portion that fits within the annular recessed slot.", "The implant can be an augment that mounts to a surgical shell or cage, and the implant can fit within one of a shoulder, hip, or ankle joint.", "In certain embodiments, the mounting member includes a plurality of flanges, at least one flange being adjustably positionable with respect to more than one of the attachment sites.", "In certain embodiments, a method of installing an orthopedic implant within a patient includes the steps of inserting the implant into the patient, selecting a site along the inserted implant to receive a first mounting member, attaching the first mounting member to the selected site, and anchoring the first mounting member to the patient.", "The selected site may be chosen from a plurality of attachment sites that are angularly spaced about the implant.", "The method may further include the step of applying a porous surface to a portion of the first mounting member.", "In some embodiments, the inserting step may include the step of mounting an acetabular shell or cage within the patient's acetabulum.", "In some embodiments, the implant may be an acetabular augment, and the inserting step may include the step of mounting the acetabular augment to an acetabular shell.", "The method may further include the step of detaching a detachable portion of the first mounting member after attaching the first mounting member to the selected site.", "In some embodiments, the anchoring step includes the step of anchoring the first mounting member to a first entry point within the selected site.", "The method may further include the step of cementing the implant into the patient's acetabulum prior to attaching the first mounting member to the selected site.", "The method may further include the step of adjustably positioning the mounting member about the circumference of the implant and along the selected site.", "In some embodiments, the mounting member may include a flange, hook, or plate.", "In certain embodiments, mounting members or augments shown and described in the figures contained herein may comprise tacks, spikes, coatings, or textured surfaces so as to improve initial fixation.", "The geographic locations of tacks, spikes, coatings, or textured surface structures may be strategically placed on select portions of a mounting member or implant so as to evenly load the mounting member or implant assembly and obtain the best biologic response initially, and over an extended period of time.", "Systems, devices, and methods described herein provide implants that can include a flange cup.", "In certain embodiments, an acetabular implant system includes an acetabular shell, a cup member that fits positionably within the acetabular shell, and at least one mounting member coupled to the cup member, where the at least one mounting member has a first portion that is attachable to a patient's bone to thereby anchor to the patient's bone.", "The mounting member may include a flange that is adjustably positionable about the cup member and has a first end with an attachment portion that anchors to the patient's bone.", "In some embodiments, the cup member includes a distal tapered end that locks to an attachment site within the acetabular shell.", "In some embodiments, the attachment site within the acetabular shell is further configured to receive a liner.", "In some embodiments, the system includes a liner disposed within the cup member.", "The cup member may be configured as a band or as a full cup such that the liner is fully supported within the cup member.", "The at least one mounting member may include a flange, hook, or plate, and the at least one mounting member may be removably attached to the cup member.", "Alternatively, the at least one mounting member is integrally provided on the cup member.", "In certain embodiments, a method of forming a surgical implant includes inserting an implant within a patient's acetabulum, providing a cup member, having at least one mounting member, within the inserted implant, aligning the cup member with the implant so that the at least one mounting member aligns with a patient bone site, and attaching the at least one mounting member to the patient's bone.", "The method may also include adjustably positioning the at least one mounting member about the cup member, wherein the at least one mounting member has a first end with an attachment portion that anchors to the patient's bone, locking a distal tapered end of the cup member to an attachment site within the implant, and disposing a liner within the attachment site.", "In some embodiments, the method may further include disposing a liner within the cup member, where the cup member is provided as band or a full cup such that the liner is fully supported within the cup member.", "The at least one mounting member may include a flange, hook, or plate, and the method may further include removably attaching the at least one mounting member to the cup member.", "Alternatively, the at least one mounting member may be integrally provided on the cup member.", "Systems, devices, and methods described herein provide implants having augments configured to attach to acetabular shells or cages, mounting members, or other augments with or without cement and configured to allow fine positional adjustments for best bone fit, coverage, and stability.", "In certain embodiments, an orthopedic implant includes an acetabular implant having a track that includes a plurality of slots and an exterior surface, an augment having a protrusion that moves within the plurality of slots, the augment having a first cam surface that forms an interface with the exterior surface, where the protrusion has an adjustable fastener that, upon adjusting, fixes the augment with respect to the implant to impede further movement.", "In some embodiment, the augment may rotate about the exterior surface.", "The adjustable fastener may be a tightening screw that extends through a through-hole in the augment and, upon tightening, expands the protrusion (which may be flared outwardly) and thereby tightens the augment within the track.", "In some embodiments, the tightening screw has a head that fits within a slot and faces an interior portion of the implant, where the slot has an interior opening that aligns with the head, and where the interior opening receives a tightening rod to tighten the screw.", "In some embodiments, the track includes a dovetail joint that receives the protrusion.", "In some embodiments, the track includes a straight portion and a curved portion.", "For example, the track can include two straight slots and a curved portion.", "In some embodiments, the track includes a J-shaped slot with a wall of the implant.", "The protrusion may be part of an intermediate locking member that is integral to the augment.", "In some embodiments, the first cam surface of the augment includes at least one trough that receives cement to bind the augment to the shell.", "In some embodiments, the augment includes a plurality of projections that form a gap and may further include a flange attached to the augment.", "In certain embodiments, a method of preparing an orthopedic implant includes the steps of providing an implant having a curved external surface and an opening in the surface, the opening having at least two portions that join at a common region but are separated by an angle of less than 180°, providing an augment having a first surface that interfaces with the curved external surface, coupling the augment and implant by an intermediate locking member, and tightening the intermediate locking member.", "In some embodiments, the method may further include the step of securing the augment to the implant by disposing cement within a trough located on the first surface.", "In some embodiments, the method may further include the step of rotating the augment with respect to the implant about the curved external surface prior to tightening the intermediate locking member, and moving the intermediate locking member within the opening prior to tightening.", "In some embodiments, the method may further include the steps of applying a fastener to the implant, so that the fastener extends outwardly from the external surface, and positioning the augment about the external surface so that the extended fastener fits between two protrusions of the augment, where the intermediate locking member is tightened with respect to the augment by a screw.", "Systems, devices, and methods described herein provide implants that create friction and allow for surrounding bone ingrowth at the interface of the implants and a patient's bone.", "In certain embodiments, an implantable orthopedic device includes an implant that has a surface that contacts a patient's joint and has a plurality of protrusions connected to the surface that rise above the surface.", "The implant may also include pores dispersed throughout the surface at the bone interface.", "The protrusions located at the surface of the implant may be blunt, or may be any other suitable shape and configuration.", "The protrusions may extend from the surface to any suitable height, such as heights between about 50 μm and about 2000 μm, heights between about 100 μm and 1100 μm, or heights between about 200 μm and 400 μm.", "The protrusions may be spaced on the surface of the implant in any suitable concentration or density.", "The desired protrusion density may also be patient-specific, and may be determined based on the density of a native bone into which a component is implanted.", "An implant may have a large number of protrusion features on its surface, and one or more of these individual features may fall outside of a desired size or spacing without affecting the overall efficacy of the surface.", "In certain embodiments, an implant includes internal or external strengthening features.", "A porous implant may include internal or external strengthening ribs to provide support to surrounding porous structures.", "A porous implant may also be coupled with a flange that has a first end for attaching the flange to the implant and a second end for attaching the flange to surrounding bone structure.", "The porous implant may also include a reticulated surface coating.", "In certain embodiments, an implantable orthopedic device is created by providing a mold having a negative impression of a porous beaded surface and providing an implant substrate to be coated.", "Particles are interposed between the implant substrate and the mold, and a pressure or elevated temperature may be applied to the mold, implant substrate, and particles.", "The implant substrate provided may be solid or may be porous, and the particles interposed between the implant substrate and the mold may be symmetric or asymmetric.", "In certain embodiments, an implantable orthopedic device is created by creating a three-dimensional model simulating an outer surface profile of a porous beaded implant and creating a three-dimensional model of an implant substrate volume.", "The model simulating an outer surface profile of a porous beaded implant is applied to the model of an implant substrate volume to create a pre-form volume, and an algorithm is applied to fill the pre-form volume with a desired reticulated structure to create a porous implant model.", "An implant is formed using the porous implant model.", "In certain embodiments, an implantable orthopedic device is created by providing a mold of an implant having an inner surface mimicking a negative image of an outer surface profile geometry of a porous beaded surface and providing a plurality of particles that are placed into the mold.", "Pressure or elevated temperature is applied to the mold and particles.", "The particles placed into the mold may be symmetric or asymmetric.", "In certain embodiments, an implantable orthopedic device is created by providing a mold of an implant having an inner surface mimicking a negative image of an outer surface profile geometry of a porous beaded surface and loading one or more foaming agents into the mold.", "A porous foam component is created in the general shape or size of the implant that has an outer surface geometry mimicking an outer surface profile geometry of a porous beaded surface.", "The porous foam component is removed from the mold, and a binding agent is applied to the porous foam component.", "A plurality of symmetric or asymmetric particles are applied to the porous foam component having the binding agent and the porous foam component, binding agent, and particles are subjected to an elevated temperature to sinter the particles together and burn out the foam component to form an implant having a roughened porous texture with an outer surface profile geometry mimicking a clinically-proven porous beaded structure.", "The porous foam component may be polymeric, and may be a polyurethane component.", "Systems, devices, and methods described herein provide implants that can be expanded or adjusted to fill bone voids in a patient's anatomy surrounding the implant.", "In certain embodiments, an orthopedic implant includes an acetabular implant with first and second portions that are separated along a side of the implant by a slit and an expansion member disposed between the first and second portions and adjustable by a tightening tool to displace the two portions relative to each other.", "The implant may also include a hinge that joins the first and second portions along a side of the implant.", "The first and second portions of an implant may comprise a solid portion, and the volume of the implant not including the solid portion may be porous.", "Any number of portions may be provided in the implant, and the implant may have any number of intersecting perpendicular slits for dividing the portions.", "The implant may be a flange connected to an acetabular shell, or may be an acetabular shell or cage.", "The implant may include a screw that passes through the implant to connect the implant to a patient's acetabulum.", "In certain embodiments, an expansion member used in an expandable or adjustable implant may be a shaped memory plug or a screw.", "The expansion member may be an augment with a curved side and a connection site that attaches to an acetabular shell.", "In certain embodiments, an orthopedic device is implanted in a patient's joint by installing an acetabular shell or cage within the joint and placing an augment between the shell and the patient's bone.", "Two portions of the augment are expanded until a first portion abuts the patient's bone and a second bone abuts the acetabular shell or cage, and the augment is anchored to the bone.", "The portions of the augment may be expanded using a tightening tool coupled to an expansion member disposed between the portions of the augment to displace the portions relative to each other.", "The expansion member used may be a shaped memory plug, a screw, or a wedge, and the tightening tool may include a torque-limiting device.", "The two portions of the augment may be expanded along a hinge that joins the portions.", "The portions of the augment may be biased towards one another.", "A screw may be passed through the shell to connect the shell to the patient's acetabulum.", "A porous surface may be applied to a portion of the augment.", "The augment may be removed via slits or flexible hinge portions provided on the augment.", "Systems, devices, and methods described herein provide implants having a plurality of projections and optional fixation elements.", "In certain embodiments, an orthopedic augment includes a base member to which at least two projections are coupled, the at least two projections having a gap therebetween, and a fixation element provided on one or more of the at least two projections.", "The fixation element may be a cement trough.", "In certain embodiments, the base member is shaped to couple with an implant.", "For example, a first surface of the base member that contacts the implant may be substantially arcuate.", "The at least two projections may be disposed in substantially the same direction.", "The length of the at least two projections may be substantially the same, or the length of one of the at least two projections may be different than the respective length of another of the at least two projections.", "In some embodiments, the base member includes one or more fixation elements such as screw holes configured to receive a fastener.", "In some embodiments, the base member includes a connection element configured to receive a driver handle for placing the orthopedic augment into a patient's joint.", "In some embodiments, the base member includes timing marks configured to align with corresponding timing marks on an implant.", "In some embodiments, the augment may further include flanges, blades, plates, or hooks attached thereto.", "In certain embodiments, a method of implanting an orthopedic device in a patient's joint may include placing an implant within the patient's joint, the implant secured to the joint via a fixation device, preparing a space in the patient's bone proximate the implant and the fixation device, providing an augment that includes at least two projections having a gap therebetween, and inserting the augment into the prepared space by positioning the augment around the fixation member such that the fixation member extends through the gap between the at least two projections of the augment.", "The method may further include forming a cement trough on one or more of the at least two projections, and setting the augment by pouring cement into the cement trough.", "In some embodiments, the method includes setting the augment using screws.", "The preparing may include rasping or reaming the patient's bone with a broach.", "The broach may have approximately the same cross-sectional profile as the augment.", "In some embodiments, the amount of bone removed may be limited by using a depth stop disposed on the broach.", "The inserting may include attaching the augment to a driver handle for positioning the augment into the prepared space.", "The method may further include aligning timing marks disposed on the augment with timing marks disposed on the implant.", "In some embodiments, the augment further comprises flanges, blades, plates, or hooks attached thereto.", "In some embodiments, the placing includes mounting an acetabular shell or cage within the patient's acetabulum.", "Systems, devices, and methods described herein provide modular orthopedic implants.", "In certain embodiments, an orthopedic device includes an implant having a plurality of attachment sites and a track that includes a plurality of slots, a mounting member having a first end that anchors to a patient's bone or soft tissue and a second end that mates with the implant at each of the plurality of attachment sites, and an augment having a protrusion that translates within the plurality of slots, the augment having a first cam surface that forms an interface with an exterior surface of the implant and rotates about that exterior surface.", "In some embodiments, the mounting member may be a flange, hook, or plate that may be adjustably positionable about the circumference of an acetabular implant.", "The flange, hook, or plate may pivot in a plane that is perpendicular to the circumference of an acetabular shell.", "In some embodiments, the mounting member is an acetabular augment that includes a base member to which at least two projections are coupled, the at least two projections having a gap therebetween.", "A cement trough may be provided on one or more of the at least two projections.", "In some embodiments, the orthopedic device further includes a cup member disposed within the implant, the cup member having one or more mounting members that are attachable to a patient's bone to thereby anchor to the patient's bone.", "The cup member may be a flange cup having one or more flanges attached thereto, and there may be a liner disposed within the cup member.", "In some embodiments, the protrusion has an adjustable fastener that, upon adjusting, fixes the augment with respect to the implant to impede further translation and rotation.", "In some embodiments, a porous surface is disposed on at least one of the implant, mounting member, and augment.", "The porous surface may include a plurality of protrusions that connect to the porous surface and rise above the porous surface and a plurality of pores dispersed within the porous surface.", "In some embodiments, the augment or the implant (or both) includes a first portion and a second portion, the first and second portions being separated along a first side of the augment by a slit, and an expansion member disposed between the first and second portions, the expansion member being adjustable by a tightening tool to displace the two portions relative to each other.", "In certain embodiments, an orthopedic implant includes an implant having a plurality of attachment means and a track that includes positioning means, a mounting member having a first end that anchors to a patient's bone or soft tissue and a second end that mates with the implant at each of the plurality of attachment means; and an augment having a protrusion that translates within the positioning means, the augment having a first cam surface that forms an interface with an exterior surface of the implant and rotates about that exterior surface.", "In some embodiments, the mounting member may be a flange, hook, or plate that may be adjustably positionable about the circumference of an acetabular implant.", "In some embodiments, the mounting member is an acetabular augment that includes a base member to which at least two projections are coupled, the at least two projections having a gap therebetween.", "BRIEF DESCRIPTION OF THE DRAWINGS The foregoing and other objects and advantages will be apparent upon consideration of the following detailed description, taken in conjunction with the accompanying drawings, in which like reference characters refer to like parts throughout, and in which: FIGS.", "1-4 show various perspectives of an illustrative rim augment or mounting member; FIGS.", "5 and 6 schematically show the use of an illustrative pivot joint to add a mounting member to an acetabular shell; FIG.", "7 shows an illustrative mounting member having a hook that receives a crossbar; FIG.", "8 shows an illustrative mounting member having a split opening that receives a crossbar; FIG.", "9 shows an illustrative T-slot into which a correspondingly-shaped receiving portion may be disposed; FIG.", "10 shows a plurality of illustrative entry portions that may be provided around an acetabular shell; FIGS.", "11-13 show an illustrative augment having one or more mounting members; FIGS.", "14-19 show one or more illustrative porous pieces or surfaces provided on bendable mounting members such as bendable flanges or plates; FIG.", "20 shows an illustrative mounting member having peripheral notches or inlets; FIG.", "21 shows an illustrative mounting member having cross-hatches or removed material from the surface; FIGS.", "22 and 23 show illustrative mounting members having various reduced surface area portions; FIG.", "24 shows an illustrative mounting member having one or more porous areas that are spaced out on the member; FIG.", "25 shows a mounting member having an illustrative orthopedic mesh; FIG.", "26 shows an illustrative mesh portion placed on an outer portion of a shell; FIG.", "27 shows an illustrative mesh that includes a plurality of trim lines that may be cut to separate the mounting members attached thereto; FIG.", "28 shows illustrative separated mounting members from the mesh of FIG.", "27 placed into a patient's hip region; FIGS.", "29 and 30 show an illustrative honeycomb design that may be provided on a mounting member or augment; FIG.", "31 shows a side elevation view of an illustrative cup member; FIG.", "32 shows a top plan view of the illustrative cup member of FIG.", "31; FIG.", "33 shows an exploded view of an illustrative cup member and acetabular shell with an optional liner therebetween; FIG.", "34 shows a perspective view of an illustrative cup member and acetabular shell; FIG.", "35 shows a side elevation view of an illustrative band cup member; FIG.", "36 shows an illustrative augment configured to attach to acetabular shells or cages, mounting members, or other augments; FIGS.", "37 and 38 show an illustrative acetabular shell or cage that includes a track; FIG.", "39 shows an illustrative augment that includes a through hole; FIG.", "40 shows an illustrative fastener having an expanding portion configured to be inserted through a track on an acetabular shell and into an augment; FIGS.", "41 and 42 show illustrative augments configured to secure to an acetabular shell or cage, mounting member, or other augment prior to insertion into a prepared bone void; FIG.", "43 shows an augment having an illustrative intermediate adapter member; FIG.", "44 shows an illustrative insertion opening in a shell adapted to receive features of the intermediate adapter system of FIG.", "43; FIG.", "45 shows an illustrative expansion member inserted into an intermediate adapter member to secure the adapter in a desired location; FIGS.", "46 and 47 show examples of a prior mounting member or augment adapted for securement to a shell; FIGS.", "48-50 show an illustrative mounting member or augment provided with an opening having multiple fixed directional threaded screw holes; FIG.", "51 shows an illustrative mounting member or augment having an expandable or deformable spherical ball member; FIG.", "52 shows an illustrative mounting member or augment having a rotatable inner cylinder insert member; FIG.", "53 shows an illustrative mounting member or augment similar to FIG.", "52 that is configured for use with a polyaxial fastener; FIG.", "54 shows an illustrative mounting member and an illustrative augment member provided with a dovetail feature; FIGS.", "55 and 56 show an illustrative dovetail feature configured to receive a fastener; FIGS.", "57 and 58 show an illustrative chock distally-connected to a surgical cable and positioned within a portion of an augment; FIGS.", "59 and 60 show an illustrative chock having an angled or inclined surface configured to receive an expansion member; FIG.", "61 shows an illustrative cable tensioning device provided on a mounting member or augment; FIGS.", "62-64 show an illustrative mounting member or augment that may be attached to an acetabular shell, cage or other augment using a separate expandable chock member and an intermediate connecting member; FIG.", "65 shows an illustrative expanding element that may be provided in an aperture of a mounting member or augment; FIG.", "66 shows an illustrative ferrule on a cable that may be positioned against an augment; FIGS.", "67 and 68 show illustrative geometries for a receiving portion of a shell, cage, or augment; FIG.", "69 shows illustrative indicia for indicating a positional relationship between the mounting member or augment and the implant to which it is to be attached; FIG.", "70 shows illustrative spikes that may be provided on mounting members or augments for improving fixation; FIG.", "71 shows an illustrative bi-lobe cup or shell; FIG.", "72 shows two augments attached together via an illustrative fastening device; FIG.", "73 shows an illustrative augment with integral spikes; FIG.", "74 shows an illustrative augment with built-in securement features; FIG.", "75-77 show various illustrative augments or porous coating portions having one or more cross-sectional areas of reduced material; FIG.", "78 shows an illustrative rotary tool; FIGS.", "79-82 shows various connection devices for securing a mounting member or an augment to an acetabular shell or cage; FIGS.", "83-85 show illustrative augments provided with an elongated undercut groove configured to receive a cam locking pin; FIG.", "86-89 show illustrative cleats provided proximate to a rim of an acetabular shell or cage, mounting member, or augment; FIG.", "90 shows illustrative cleat portions configured for securing soft tissues; FIGS.", "91 and 92 show an illustrative augment attached peripherally to an acetabular shell or cage via a recess; FIGS.", "93 and 94 show an illustrative mounting member attached peripherally to an acetabular shell or cage via a recess; FIG.", "95 shows an acetabular shell or cage having an illustrative annular protrusion; FIG.", "96 shows a first view of an illustrative implant component; FIG.", "97 shows a second view of an illustrative implant component; FIG.", "98 shows an illustrative implant coating volume having a spherical bead surface profile; FIG.", "99 shows an illustrative unit cell having a porous structure; FIG.", "100 shows a cross-section of an illustrative coating volume with a spherical bead profile and a porous structure; FIG.", "101 shows a first illustrative SEM image of a porous surface; FIG.", "102 shows a second illustrative SEM image of a porous surface; FIGS.", "103-107 show illustrative expandable/adjustable augments; FIG.", "108 shows an illustrative expansion member; FIGS.", "109-113 show illustrative expandable/adjustable augments; FIG.", "114 shows an illustrative expandable/adjustable augment with multiple expansion screws; FIG.", "115 shows an illustrative expandable/adjustable implant shell; FIGS.", "116 and 117 show a front perspective view and a back view, respectively, of an illustrative augment; FIG.", "118 shows a top plan view of an augment illustratively installed on an acetabular shell; FIGS.", "119-122 illustrate exemplary methods for installing an augment into a patient's joint; FIG.", "123 shows a front perspective view of an illustrative augment having three projections; FIG.", "124 shows a top plan view of an augment having an illustrative flange; FIG.", "125 shows a partial cross-section elevation view of an illustrative augment with a flange installed in an acetabulum; FIGS.", "126 and 127 show an illustrative augment and flange combination; FIGS.", "128 and 129 show an illustrative posterior wall augment and mounting member combination; FIGS.", "130 and 131 show an acetabular shell or cage with an illustrative concentric frustoconical tapered inner surface; FIGS.", "132-134 show an illustrative deep profile acetabular augment; FIGS.", "135-140 show an illustrative superolateral augment or flange member; FIGS.", "141-143 show an augment or mounting member incorporating variable locking angle screw geometry; FIGS.", "144-148 show various examples of screws that may be used with augments or mounting members; FIG.", "149 shows an illustrative screw having a rounded, tapered, or spherical head; FIGS.", "150-155 show an augment or mounting member incorporating variable locking angle screw geometry; FIG.", "156 shows an illustrative screw head including a polymer that is deformed by an engagement structure provided on an augment or mounting member; FIG.", "157 shows an illustrative porous outer layer applied to a solid substrate; FIG.", "158 shows an illustrative solid insert pressed into a porous mounting member or augment; FIG.", "159 shows an illustrative augment shaped in the form of an “L”; FIGS.", "160 and 161 schematically illustrate the difference in bone density and strength between normal bone (FIG.", "160) and osteoporoic bone (FIG.", "161); FIG.", "162 shows a conventional cancellous bone screw; FIG.", "163 shows an illustrative bone screw having a proximal outer straight thread portion and a distal tapering thread portion; FIG.", "164 shows an illustrative bone screw having a larger outer crest thread diameter than the bone screw of FIG.", "162; FIG.", "165 shows an illustrative bone screw having a fully tapered thread; FIG.", "166 shown an illustrative augment having recess portions alongside a split portion; FIG.", "167 shows an illustrative augment having a slot that is shaped to correspond to an appropriate removal tool; FIGS.", "168-170 show illustrative crescent blades or two-sided blades that can rotate into a slot to affect removal of an augment; FIG.", "171 shows an illustrative augment for use with a blade removal tool; FIGS.", "172 and 173 show an illustrative removal tool that may include a collapsible blade; FIGS.", "174 and 175 show illustrative augments predesigned for removal; FIG.", "176 shows an illustrative contact-reducing augment; FIG.", "177 shows an illustrative augment having one or more coated portions; FIGS.", "178 and 179 show illustrative anchor screws adapted for securement of an implant to surrounding bone; FIGS.", "180 and 181 show an illustrative anchor screw screwed into place and a smaller screw that may be inserted into a cannulated portion of the anchor screw; FIGS.", "182 and 183 show an illustrative anchor screw configured to be used to secure a graft material; FIG.", "184 shows an illustrative fastener that includes a porous shaft; FIGS.", "185-187 show various illustrative augments in the shape of an acetabular cup and provided with a number of openings disposed circumferentially around the augment; FIGS.", "188-190 show illustrative triangular-shaped inserts that may be positioned in the openings of the augments of FIGS.", "185-187; FIG.", "191-193 show illustrative curved inserts that may be positioned in the openings of the augments of FIGS.", "185-187; FIGS.", "194 and 195 show an illustrative insert having a spike extending therefrom; FIGS.", "196 and 197 show an illustrative insert having screw threads extending from a surface thereof; FIG.", "198 shows an illustrative insert having a back portion provided with a mounting feature onto which supplemental augments or mounting members may be mounted; FIG.", "199 shows an illustrative supplemental augment having a complementary track to the mounting feature provided in FIG.", "198; FIG.", "200 shows an illustrative taper lock; FIG.", "201 shows an illustrative ledge that may be provided around at least a portion of an opening on the outer wall of an augment; FIG.", "202 shows an illustrative mounting member having openings for correspondingly-shaped inserts; FIG.", "203 shows illustrative inserts having lattice structures provided thereon; FIGS.", "204 and 205 show an illustrative supplemental augment coupled to an augment; FIG.", "206 shows an illustrative shell having a track that is undercut so as to form a dovetail joint with an augment; FIG.", "207 shows an illustrative augment including a channel shaped to receive a connecting member; FIG.", "208 shows an illustrative connecting member; FIG.", "209 shows an illustrative augment that spans a pelvic defect; and FIG.", "210 shows an illustrative secondary augment for use with a primary augment.", "DETAILED DESCRIPTION To provide an overall understanding of the systems, devices, and methods described herein, certain illustrative embodiments will be described.", "Although the embodiments and features described herein are specifically described for use in connection with acetabular systems, it will be understood that all the components, connection mechanisms, adjustable systems, fixation methods, manufacturing methods, coatings, and other features outlined below may be combined with one another in any suitable manner and may be adapted and applied to medical devices and implants to be used in other surgical procedures, including, but not limited to: spine arthroplasty, cranio-maxillofacial surgical procedures, knee arthroplasty, shoulder arthroplasty, as well as foot, ankle, hand, and other extremity procedures.", "Various implants and other devices described herein in their various embodiments may be used in conjunction with any appropriate reinforcement material, non-limiting examples of which include bone cement, appropriate polymers, resorbable polyurethane, and/or any materials provided by PolyNovo Biomaterials Limited, or any suitable combinations thereof.", "Further non-limiting examples of potential materials that may be used are described in the following references: U.S. Patent Application Publication No.", "2006/0051394, entitled “Biodegradable Polyurethane and Polyurethane Ureas,” U.S. Patent Application Publication No.", "2005/0197422, entitled “Biocompatible Polymer Compositions for Dual or Multi Staged Curing,” U.S. Patent Application Publication No.", "2005/0238683, entitled “Biodegradable Polyurethane/Urea Compositions,” U.S. Patent Application Publication No.", "2007/0225387, entitled “Polymer Compositions for Dual or Multi Staged Curing,” U.S. Patent Application Publication No.", "2009/0324675, entitled “Biocompatible Polymer Compositions,” U.S. Patent Application Publication No.", "2009/0175921, entitled “Chain Extenders,” and U.S. Patent Application Publication No.", "2009/0099600, entitled “High Modulus Polyurethane and Polyurethane/Urea Compositions.” Each of the prior references is incorporated by reference herein in its entirety.", "FIGS.", "1-4 show some embodiments where a rim augment or a mounting member may be configured for a left hip.", "Rim mounting member 202 may be press-fit onto an outer diameter 203 of an acetabular cup 204 (e.g., acetabular shell, cup, cage, or augment).", "The rim mounting member 202 has at least one curved or spherical inner surface 205 that matches a contour profile 207 of an outer surface of the acetabular cup 204 to which the mounting member 202 is attached.", "In some embodiments, more than one opposing curved or spherical surfaces may be provided on the inner surface 205 of the rim mounting member 202, each curved or spherical surface comprising a similar radius of curvature.", "The size, shape, and profile of these one or more curved or spherical surfaces correspond to the outer diameter and outer surface profile of the acetabular cup 204.By providing two curved or spherical surfaces, for example, the rim mounting member 202 may be configured for universal use and, therefore, may be flipped or inverted in order to allow its use with a left to a right acetabular cup.", "In other words, the rim mounting member 202 may be inverted when used in conjunction with a contralateral hip.", "It may further be provided in any suitable number of available sizes in order to fit multiple cup sizes (e.g., acetabular cups having outer diameter sizes ranging between approximately 30 mm and 90 mm).", "One or more flanges or other mounting members, or any combinations thereof, may be provided on mounting member 202.In the particular embodiment shown, three mounting members 208 are shown, which extend radially from the rim of the acetabular cup 204.The mounting members 208 are configured to be bent, cut, or otherwise shaped as needed in order to conform to the pelvis of a particular patient's anatomy.", "Alternatively or additionally, one or more of the mounting members 208 may be oriented at predetermined radial locations circumferentially around the rim of the acetabular cup to correspond with, engage, or otherwise accommodate the ilium, ischium, superior ramus, or any other suitable patient anatomy.", "It should further be understood that any of the alternate and adjustable mounting and securement mechanisms described herein may also be used with these embodiments.", "The described rim mounting members are of particular use in acetabulums having defects and damage along the acetabular rim.", "The holes of the mounting members 208 may be threaded, unthreaded, or partially threaded, and may be fixed or polyaxial.", "In some embodiments, attachment sites may include variable low-profile holes that allow for locking at a variety of angles.", "FIGS.", "5-8 schematically illustrate the use of a pivot joint 210 to add a mounting member (such as a flange, plate, or any other attachment or mounting member) to an acetabular shell, cup member, or augment according to some embodiments.", "For example, as shown in FIG.", "5, a crossbar 212 may be provided in one or more recesses 214 on an upper shell surface of proximal rim portion 216 of the acetabular shell 218 and aligned generally parallel to a tangent of the shell 218 adjacent its rim.", "The one or more recesses 214 may comprise, for instance, a V-shaped slot, although any other suitably-shaped slot may be used.", "A plurality of attachment sites may be provided, with each being spaced angularly about the rim or other portion of the implant.", "This allows a plurality of positioning options for mounting members and gives the surgeon more flexibility to position the attachments along the implant for ease of anchoring.", "The acetabular shell 218 includes a ridge 230 on inner surface 228 that mates with a correspondingly-shaped ridge of a liner, for example, although any other suitable mounting member or augment may have a similarly-shaped ridge for mating with ridge 230.In some embodiments, the ridge 230 may be provided alternatively, or additionally, on outer surface 226.A mounting member 220 has a first end 221 that anchors to the patient's bone or soft tissue and a second end or receiving portion 223 that mates with the implant, such as acetabular shell 218, at each of the plurality of attachment sites provided along, for example, the crossbar 212.The second end or receiving portion 223 of mounting member 220 may have a hook or a split opening that receives the crossbar 212.For example, mounting member 220′ of FIG.", "7 includes a hook 222, and mounting member 220″ of FIG.", "8 includes a split opening 224, which may also be referred to as a split eyelet.", "The mounting members shown in FIGS.", "6-8 may be moved independently of the shell positioning.", "One of the advantages provided by this design is that the flanges and other mounting members are completely modular and do not have to be positioned in the same discrete place or in only one of a few pre-determined locations, but can instead be positioned anywhere around the rim of the shell and can pivot in a plane that is perpendicular to the plane defined by the circumference of the shell.", "FIGS.", "9 and 10 illustrate some embodiments where one or more mounting members and/or augments translate or ride, or otherwise move, in a circumferentially-extending T-slot, dovetail slot, tongued groove, or undercut groove provided in an outer shell surface 244 proximate to the rim.", "The mounting members or augments may be configured with a receiving portion that may enter a portion of the shell 246 and slide within the circumferentially-extending T-slot, dovetail slot, tongued groove, or undercut groove.", "For example, FIG.", "9 shows a T-slot 240 on an outer surface 244 of shell 246 into which a correspondingly-shaped receiving portion may be disposed.", "The mounting members or augments can revolve around the shell to the proper angular position around the rim and then be locked, retained, or otherwise secured in position.", "For example, the receiving portions may include a locking member or an expanding member that locks or expands, respectively, when the mounting member or augment is place in a particular location along the shell to thereby secure the mounting member or augment into position.", "A plurality of attachment sites may be provided, with each being spaced angularly about the rim or other portion of the implant.", "This allows a plurality of positioning options, as opposed to the discrete few options typically provided, for example, where the mounting member or augment must be positioned at the discrete location where attached.", "Similar to the acetabular shell 218 of FIG.", "5, shell 246 may also include a ridge 248 on inner surface 242 that mates with a correspondingly-shaped ridge of a liner, for example, although any other suitable mounting member or augment may have a similarly-shaped ridge for mating with ridge 248.In some embodiments, the ridge 248 may be provided alternatively, or additionally, on outer surface 244.One or more entry points may be provided within the T-slot, dovetail slot, tongued groove, undercut groove, or other attachment site to allow quick insertion, placement, access, or removal of the flanges, plates, or augments with respect to the shell.", "Particularly, multiple entry portions may be configured to allow one or more mounting members or augments to be engaged with the shell and positioned angularly around the shell even after the shell has been impacted into a prepared acetabulum and portions of the shell proximate to the rim are obstructed by bone, grafts, or cement.", "For example, as shown in FIG.", "10, a plurality of entry portions 254 may be provided around shell 258.A mounting member 250 that includes a receiving portion 252 shaped as a key may be engaged with a reciprocally-shaped groove 256 at one of entry portions 254.The mounting member 250 may engage with the shell by placing mounting member 250 into one of the grooves 256 at an entry point 254 and then positioned angularly around the shell therefrom to one of a plurality of attachment sites.", "Furthermore, mounting member 250 may be inserted into a first entry point 254, rotated about the shell 258 to a second entry point 254, and then removed.", "In the embodiments shown in FIGS.", "11-13, one or more mounting members 262 (shown as flanges, but not limited thereto) are added to an acetabular augment 260.The mounting members 262 may be permanently fixed or detachable, and may be adjustably positionable about augment 260 as described above.", "Mounting members 262 may have frangible portions 264 between screw holes 266 or other structures for receiving fasteners.", "The frangible portions 264 may be provided, for example, as reduced cross-sections that allow bending or breaking or cutting of the mounting members 262 without disturbing the internal geometries of the screw holes 266.In certain embodiments, the frangible portions 264 may be prestressed or otherwise pretreated to make the frangible portions 264 weaker than other areas of the mounting members 262.Screw holes 266 may be smooth or provided with threads or other protrusions to be used with locking head screws or polyaxial screws.", "The screw holes 266 may be conventional holes, locking holes, or slots.", "The holes may be threaded, unthreaded, or partially threaded, and may be fixed or polyaxial.", "In some embodiments, screw holes 266 may include variable low-profile holes that allow for locking at a variety of angles.", "The augment 260 and mounting members 262 may be implanted proximate a patient's acetabulum.", "For example, as shown in FIGS.", "12 and 13, augment 260 having mounting members 262 is implanted into an area having a posterior column defect region 268.As shown in the embodiments depicted in FIGS.", "14-19, one or more porous pieces or surfaces may be provided on bendable mounting members such as bendable flanges or plates, or any of the other mounting members.", "In some instances, solid or rigid augments may replace bendable mounting members.", "The mounting members may be modular, attachable, or integrally-provided on an acetabular implant structure such as an acetabular shell.", "As shown in FIG.", "14, a mounting member 280 includes a porous coating 282 about a periphery while top portion 284 is substantially smooth and flat.", "Mounting member 280 also includes a plurality of fastening through-holes 286 for receiving screws or other fastening members.", "Through-holes 286 may include conventional holes, locking holes, or slots.", "The holes may be threaded, unthreaded, or partially threaded, and may be fixed or polyaxial.", "In some embodiments, through-holes 286 may include variable low-profile holes that allow for locking at a variety of angles.", "Exemplary bending motion of flanges is shown with respect to FIGS.", "15 and 16.A mounting member such as flange 290 has a first portion 291 and a second portion 292 and is flat.", "Flange 294 may be bent in a first direction about bending axis 295 such that a second portion 298 is bent relative to a first portion 296.Because in some instances there may be a chance that porous structures integrally provided on mounting members (such as porous coating 282 of FIG.", "14) may fracture, delaminate, or separate from the mounting members during or after bending, porous pieces may be provided separate from and/or spaced between securement devices such as screw holes, as shown in FIG.", "17 and FIG.", "19.In FIG.", "17, a separate porous in-growth pad 306 is provided, which can be secured to a bendable mounting member 300 via screw 304, so that the bendable mounting member 300 may still be bent, while also featuring the desired in-growth advantages of the porous in-growth pads 306, without being subject to delamination or decoupling upon bending.", "This allows bending of the mounting members without stressing the struts of each porous piece.", "The porous piece may be positioned before or after bending.", "Screws 302 may be provided for securing the mounting member 300 to a patient's bone or soft tissue, an acetabular shell, augment, or other mounting member.", "In lieu of screw holes, or in addition to screw holes, in some embodiments spikes, tacks, or other appropriate fasteners may be utilized.", "J-slots may be provided in the porous pieces or the mounting members to allow adjustability of the position of the porous piece relative to the augment or mounting member in both rotation and translation.", "For example, FIG.", "18 shows a mounting member 270 having a plurality of screw holes 272 and J-slots 274.Screws or any appropriate fixation members may be used to rigidly fix the porous pieces to the augment or mounting member, or other members such as shape memory or deformable pegs (e.g., rivet structure) may be used to rigidly fix the porous pieces to the augment or mounting member.", "In some instances, members fixing the porous pieces to the augment or mounting member may be configured to allow the porous pieces to move during bending of the mounting members.", "As shown in FIG.", "19, a mounting member 310 includes a first portion 312 that is bent in a first direction about bending axis 320 relative to a second portion 314.The first portion 312 and second portion 314 of mounting member 310 each include J-slots 316 to allow adjustability of the position of the porous pieces 318 attached thereto relative to mounting member 310.FIGS.", "20-24 show various embodiments of adjustable and/or flexible mounting members.", "Stiff mounting members, such as stiff plates or flanges, or any other suitable stiff members that may be used to extend from a surgical implant for securing it into place, may be difficult to bend or position.", "It may thus be desirable in some instances to provide mounting members that are configured to bend or otherwise adjust.", "FIG.", "20 shows a mounting member 340 having peripheral notches or inlets 342 cut into the profile of the mounting member 340.In some embodiments, these features allow mounting member 340 to be flexed, bent, shaped, or otherwise contoured to bone or around other devices.", "In the embodiment shown, the notches 342 are Z-shaped, but it will be understood that any appropriate shape, such a J-slots, C-slots, V-slots, any other appropriate shapes, or any combinations thereof, may be used.", "FIG.", "21 shows a mounting member 350 having cross-hatches or removed material 352 from the surface, thereby reducing the cross-sectional surface area of the member.", "These features may make it easier for mounting member 350 to flex, bend, shape, or contour.", "FIGS.", "22 and 23 show further embodiments of mounting members that may have various reduced surface area portions, such as notches, indents, removed material, cut outs, or other portions of reduced surface area, or any combinations thereof.", "For example, mounting member 360 includes notches 362 and cross-hatches or removed material 364.These reduced surface area portions may have any appropriate profile or cross-sectional shape, examples of which may be circular, curved, triangular, irregularly-shaped or any other appropriate option.", "The reduced surface area portions may help enhance the flexibility or bendability of the member.", "FIG.", "24 shows a mounting member 370 having one or more porous areas 372 that are spaced out on the member 370.In certain embodiments, the mounting member 370 may be bent or otherwise configured as desired, without being limited by the porous areas, as discussed above in connection with FIGS.", "14-19.For example, mounting member 370 may be bent about region 374 or 376 without introducing bending stresses to the porous areas 372 or substantially limiting the bending stresses on porous areas 372.Mounting member 370 may have any of the above-discussed reduced surface area portions, or mounting member 370 may be provided as a typical, traditional mounting member.", "In the embodiments shown in FIGS.", "25-28, one or more mounting members and/or augments may be integrally provided with orthopedic mesh to define one or more mesh mounts or void fillers.", "FIG.", "25 shows a mounting member 380 having an orthopedic mesh 382.In FIG.", "26, the orthopedic mesh portion 382 may be placed on an outer portion 384 of the shell 386 between bone, and a cement mantle can fill between the mesh 382.The cement mantle rigidly connects the mounting member 380 (or, in some embodiments, an augment) to the shell 386 via the surgical mesh 382.Rapid manufacturing techniques may be used to simultaneously create the mounting members or augments integrally with the orthopedic mesh portion.", "The mesh 382 may be honeycomb, diamond, or other weave pattern, or any combination thereof, and may come in multiple thicknesses.", "Mesh portion 382 may be oversized, customized for an individual patient, and/or standardized and trimmed by the surgeon to fit a particular patient's needs.", "Fasteners of all types may be inserted through one or more cells of the mesh 382, as well as through the one or more mounting members or augments to further secure the implant to bony anatomy.", "For example, as shown in FIG.", "25, a first screw 388 may be inserted through cell 390, and a second screw 394 may be inserted through one of the plurality of screw holes 392 of mounting member 380.Screw holes 392 may include conventional holes, locking holes, or slots.", "The holes may be threaded, unthreaded, or partially threaded, and may be fixed or polyaxial.", "In some embodiments, screw holes 392 may include variable low-profile holes that allow for locking at a variety of angles.", "Soft tissues may be reattached using the porosities of the mesh 382 as suture anchors, or simply as a bioscaffold.", "If desired, preformed trim lines may be provided by forming predetermined frangible portions in various areas of the mesh, in order to help configuration of the device for a particular patient.", "For example, as shown in FIG.", "27, mesh 400 includes a plurality of trim lines 402 that may be cut to separate the mounting members attached thereto, such as mounting members 404.The separated mounting members 404 and the mesh 400 may then be placed into a patient's hip region 406 as shown in FIG.", "28.FIGS.", "29 and 30 illustrate some embodiments of a honeycomb design that may be provided on a mounting member or augment in order to control cement mantle thickness and spacing between said mounting member or augment and an adjacent acetabular shell, augment, bone, or other implant.", "For example, mounting member 410 of FIG.", "29 includes honeycomb portion 412 provided on an attachment surface portion 414 of the mounting member 410.The honeycomb feature 412 may be provided as any desired geometric shape.", "The mounting member 410 (or, in some embodiments, the augment) may comprise one or more securing holes 416 for receiving a surgical fastener 418 such as a polyaxial screw, cancellous screw, peg, or other securing device.", "The securing holes 416 may include conventional holes, locking holes, or slots.", "The holes may be threaded, unthreaded, or partially threaded, and may be fixed or polyaxial.", "In some embodiments, securing holes 416 may include variable low-profile holes that allow for locking at a variety of angles.", "The attachment portion 414 of the mounting member 410 may extend generally perpendicularly from another portion 415 of the mounting member 410, and may comprise one or more concave curved surfaces 417 configured to abut an outer portion 422 of an acetabular shell 420, or one or more convex surfaces (not shown) configured to abut an inner portion of a prepared acetabulum.", "In the embodiments shown in FIGS.", "86-89, cleats may be provided proximate to a rim of an acetabular shell, cage, mounting member, or augment.", "For example, in some embodiments, one or more cleats 780 and 781 may extend or project from a superior aspect of a rim portion 782 of an acetabular shell 784 as shown.", "Cleats 780 and 781 may be used to secure soft tissues to the acetabular shell 784 or may serve as a means to attach secondary augments or any type of mounting member 786 to the acetabular shell 784.In the particular instance shown in FIGS.", "88 and 89, a “quarter-turn” fastener connector arrangement is utilized.", "The quarter-turn fastener arrangement may comprise, for instance, a generally T-shaped male member 790 located on one or more regions of an acetabular shell, cage, or augment, and one or more complementary female members 792 located on more secondary augments or mounting members.", "The one or more secondary augments or mounting members engage the one or more male members 790 on the acetabular shell, cage, or augment in one degree of rotation, and then are rotated by a specified or variable number of degrees (e.g., 90 degrees) to lock the one or more secondary augments or mounting members to the one or more male members 790.Of course, one of ordinary skill in the art would appreciate that the male and female members could be reversed to provide the same function.", "It should also be understood that other locking mechanisms may be used.", "FIG.", "90 further depicts one or more cleat portions 794 located at various portions of an acetabular shell or cage 796 (or, in some embodiments, an augment) configured for securing soft tissues.", "The one or more cleat portions 794 can be arranged in any particular fashion around the acetabular shell 796; however, it is preferred that the cleats 794 extend proximally from a rim portion or otherwise away from the acetabular shell 796 in order to provide clearance from liner-mating surfaces, cement mantle surfaces, bone contacting surfaces, and bony anatomy, for example.", "Cleat portions 794 may comprise suturing holes, roughened surfaces, clamps, hooks, or biologic coatings, or any other appropriate protrusions, or combinations thereof, to encourage fixation of the soft tissues to the implant (e.g., acetabular shell 796).", "For example, as shown in the inset of FIG.", "55, sutures may be wrapped around cleat portion 794 and then secured to surrounding soft tissues.", "FIGS.", "91-95 illustrate embodiments wherein a mounting member 802 or an augment 804 may be attached peripherally to an acetabular shell or cage 806 via a recess 800 provided proximate a rim portion 808 of the acetabular shell or cage 806.The recess 800 is sized to accept a protruding insertion portion 810 of the mounting member 802 or a protruding insertion portion 812 of the augment 804, and the recess 800 may extend annularly circumferentially around the rim portion 808 to allow orbital placement of the mounting member 802 or augment 804 around a periphery of the shell or cage 806.The mounting member 802 or augment 804 may be inserted into the acetabular shell or cage 806 before or after shell/cage impaction or cementing into a prepared acetabulum.", "One or more screw holes in the mounting member (e.g., screw holes 814) or augment (e.g., screw holes 816) rigidly secure the mounting member 802 or augment 804 to the bone and prevent orbital movement of the mounting member 802 or augment 804 around the shell or cage 806.Screw holes 814 and 816 may include conventional holes, locking holes, or slots.", "The holes may be threaded, unthreaded, or partially threaded, and may be fixed or polyaxial.", "In some embodiments, screw holes 814 and 816 may include variable low-profile holes that allow for locking at a variety of angles.", "Once the mounting member 802 or augment 804 is positioned, the cantilever force pushes the rim 808 of the shell or cage 806 toward bone.", "The protruding insertion portion of the mounting member (e.g., portion 810) or augment (e.g., portion 812) provides a hold-down force to the shell or cage 806 after a screw is inserted through the mounting member 802 or augment 804 and into surrounding pelvic bone.", "FIGS.", "91 and 92 show an augment 804 being positioned with respect to an acetabular shell or cage 806.FIGS.", "93 and 94 illustrate a mounting member 802 being positioned with respect to an acetabular shell or cage 806.The mounting member 802 is shown as having multiple securing holes 814 for use with fasteners.", "Securing holes 814 may be smooth, tapered, or threaded and may be used with any appropriate fastener, including but not limited to polyaxial screws.", "The securing holes 814 through the mounting member 802 (or securing holes 816 through the augment 804) may be positioned at any appropriate angle, as shown, such as parallel to the member, oblique through the member, or otherwise as desired.", "While not shown, a honeycomb feature may be placed on outer portions of the mounting member 802 or augment 804 to provide spacing for a cement mantle between the mounting member 802 or augment 804 and surrounding bone.", "Moreover, porous structures, textured surfaces, biologic coatings, or orthopedic meshes may be integrally provided on, or incorporated between outer surfaces of the mounting members 802 or augments 804 and surrounding bone.", "In the embodiments of FIGS.", "93 and 94, a recess 800 in the shell or cage 806 is defined by a proximally-extending lip 818 such that the mounting member 802 will sit on bone surrounding the acetabulum.", "In this way, the mounting members 802 will not interfere with the press-fit area between the shell 806 and prepared acetabulum adjacent the acetabular rim 808.Moreover, because the connection is configured to allow mounting members 802 to sit on surrounding bone, the surrounding bone does not need to be countersunk or otherwise prepared to receive mounting members 802.FIG.", "95 depicts an acetabular shell or cage 820 comprising an annular protrusion 822 along a rim portion 824 of the acetabular shell 820.The annular protrusion 822 may extend partially around (as shown) or entirely around the circumference of the acetabular shell 820, or one or more protrusions may be provided in any fashion around the acetabular shell 820.The annular protrusion 822 may comprise an annular lip 826 defining an annular undercut groove 828 running circumferentially around the acetabular shell 820 proximate the rim portion 824.The annular protrusion 822 may comprise one or more openings 830 for receiving sutures (e.g., for soft tissue or capsule re-attachment) or fasteners 832 such as set screws for contacting and frictionally engaging surfaces (e.g., divots) provided on protruding insertion portions 834 and 836 of mounting members 840 or augments 838 alike.", "Fasteners 832 may be inserted into openings 830 located circumferentially laterally of the insertion portions 834 and 836 to serve as stops for preventing or limiting rotational movement of the attached mounting members 840 or augments 838.The mounting members 840 or augments 838 may be secured down to surrounding bone after being inserted into the annular undercut groove 828 via long bone screws, thereby providing a hold-down force to the acetabular shell or cage 820.The hold-down forces provided may complement the press fit, threaded fit, or cemented fixation between the acetabular shell or cage and surrounding prepared acetabular bone.", "In the instance shown, shell 820 is provided as a “hooded” shell similar to a cage, and may act as a buttress for a cemented or pressed-in liner to support various liner inclinations in varying degrees of acetabular or pelvic degradation, although it will be understood that these features may be provided on any other type of shell or cage.", "FIGS.", "31-34 show a cup member 120 intended for insertion into an acetabular cup 140 (also referred to as an “acetabular shell,” “shell,” “cage,” or “cup”), and in some embodiments, between the acetabular cup 140 and a liner 160 that may be disposed within the cup member 120.The cup member 120 is provided with various mounting members (also referred to as “attachment members”), such as flanges, blades, hooks, or plates, where each respective mounting member may be removably or integrally provided on the cup member.", "As shown in FIG.", "31, for example, cup member 120 includes blade 102, hook 104, and flange 106.The mounting members such as blade 102, hook 104, and flange 106, may be adjustably positionable about the cup member (e.g., about the perimeter of the cup member or about any other suitable location on the cup member).", "For example, a removable mounting member may be attached to the cup member and then, while still attached, positioned from a first location to a second location along the cup member.", "Alternatively, the removable mounting member may be removed and then repositioned.", "As another example, an integral mounting member (e.g., a mounting member that is not removable) may nonetheless be adjustably positionable about the cup member.", "In some embodiments, an integral mounting member may be rigidly fixed in a first location and may not be adjustably positionable about the cup member.", "The portion of the mounting members that is not attached to the cup member may be used to attach or anchor to a patient's bone.", "For example, as shown in FIG.", "31, flange 106 includes a portion 108 attached to the cup member 120 and an attachment portion 110 that is attachable to a patient's bone to thereby anchor to the patient's bone.", "Attachment portion 110 includes a plurality of screw holes 111 for anchoring flange 106 to the patient's bone, although it will be understood that any suitable attachment mechanism may be used.", "For example, hook 104 includes a curved end 105 to thereby hook onto a patient's bone.", "Screw holes 111 may include conventional holes, locking holes, or slots.", "The holes may be threaded, unthreaded, or partially threaded, and may be fixed or polyaxial.", "In some embodiments, screw holes 111 may include variable low-profile holes that allow for locking at a variety of angles.", "Other suitable attachment mechanisms may include bone cement, shape-memory polymer fixation members, expanding screws, any other suitable mechanism for attaching a mounting member to a patient's bone or soft tissue, or any combinations thereof.", "FIGS.", "31-34 depict some embodiments of a cup member 120 suitable for receiving a polymer, ceramic, or metal liner 160, the cup member 120 having mounting members that extend radially therefrom.", "The cup member 120 may be placed into an acetabular shell 140, and the mounting members such as blade 102, hook 104, and flange 106 may be disposed around the rim 142 of the shell 140 when the cup member 120 is inserted into and substantially fully seated in the shell 140.As shown in FIG.", "31, in some embodiments, the outer portion 116 of the cup member 120 may have a conical taper 112 for frictional locking engagement with a complementary conical taper 114 in an acetabular shell 140.The taper 114 of acetabular shell may be contoured to receive the specific type of conical taper 112 of the cup member 120.In some embodiments, multiple cup members may be available, and each may have a profile similar to conical taper 112 such that they can be interchangeably placed into acetabular shell 140.The complementary conical taper 114 in the acetabular shell 140 may also be used to accept a ceramic liner 162 having a conical taper similar to that of the cup member 120, providing various options during surgery.", "The ceramic liner 162 may be utilized to allow a cup member 120 to be used with an acetabular shell 140 even when taper 112 of the cup member does not match the taper 114 of the acetabular shell.", "For example, the inner surface of ceramic liner 162 may be shaped to engage the taper 112 of the cup member 120 while the exterior surface of ceramic liner 162 has a different shape to engage the taper 114 of the acetabular shell 140.Mounting members may be provided as one or more flanges, blades, hooks, or plates which may be rigid or bendable, and which may have any other appropriate features described herein.", "In certain embodiments, as shown in FIG.", "33, a polyethylene or ceramic liner 160 is placed within the cup member 120 (which may also be referred to as a “flange cup”) to line the inside of the cup member 120.The cup member 120 may comprise integral flanges that rest superiorly of the interior surface that accepts the liner.", "Alternatively, if metal on metal articulation is desired, a metal liner that incorporates integrally-formed flanges may be used.", "However, it will be understood that the modular options described herein may also be used.", "The cup member may contain internal scallops suitable for use with current polyethylene liners such that it may be used with the system, for example, disclosed in the '705 patent application.", "When the described cup members 120 are used, the liners 160 may need to be provided slightly smaller than those typically provided within an acetabular shell that does not have a cup member therein in order to provide clearance between the liner and the cup for a taper lock.", "Alternatively or additionally, smaller femoral heads may be used.", "In some embodiments, it may be desirable for a liner to sit in and be fully supported by a cup member such that the liner is not suspended.", "In some instances, suspended liners can creep or deform.", "As shown in FIG.", "33, the cup member 120 is provided as a full cup rather than just a band with adjustable mounting members so that it can fully support a liner if used.", "However, in other embodiments, the cup member does not necessarily have to be a full cup, and may not necessarily even have a cup shape.", "For example, as shown in FIG.", "35, a cup member 180 is provided as a band cup having mounting members 182.A liner 164 may be placed within the band cup member 180 such that a portion 168 of the liner 164 is suspended below the band cup.", "In some embodiments, an advantage provided by the cup member is that the mounting or attachment members are provided on the separate cup member and not on the acetabular shell.", "This allows the acetabular shell to be positioned independently of the cup member, providing a greater range of modularity and adjustment options.", "Another advantage provided by the cup member may be seen during revision surgeries.", "Rather than having to remove the acetabular shell during revision surgery, a surgeon may remove the liner from within the acetabular shell, insert a cup member having one or more mounting members into the acetabular shell, and then insert a new liner into the cup member.", "The embodiments shown in FIGS.", "36-50 provide augments that may be configured to attach to acetabular shells or cages, mounting members, or other augments without cement, and are also configured to allow fine positional adjustments for best bone fit, coverage, and stability.", "It will be understood that the features and components described in connection with the augments of FIGS.", "36-50 may also be applied to mounting members, such as hooks, flanges blades, or any other suitable mounting members, that may be configured to attach to acetabular shells or cages, augments, or other mounting members.", "FIG.", "36 illustrates certain embodiments wherein an augment 450 may be placed on a periphery of a hemispherical acetabular shell, cage, or other augment.", "As shown in FIGS.", "37 and 38, a shell or cage 460 may comprise a track 462 that is undercut so as to form a dovetail joint 461 with a mounting member or an augment.", "The track 462 may be provided as a J-shaped slot (as shown), T-shaped slot, H-shaped slot, or any other shape involving combinations of straight and/or curved segments.", "The track 462 preferably includes at least two portions or slots, at least one of which can receive a complementary connector or protrusion from the augment or mounting member.", "As shown in FIG.", "37, for example, the first portion or slot 464 and second portion or slot 466 join about common region 468 but are separated out at distal ends 465 and 467 by angle θ, which is less than 180° in the example.", "The at least two portions thereby permit the augment or mounting member to be adjustably positioned along the surface of the shell, cage, or other augment by sliding the augment (and its connector) along the track and securing it at the desired location.", "For example, the augment could be secured in one of the at least two portions (such as slot 464), or the other of the at least two portions (such as slot 466), or in between.", "The mounting member or augment may have a protrusion that is flared outwardly, and may be generally frustoconical, bulbous, or otherwise forms a portion of a male portion of a dovetail joint.", "For example, as shown in FIG.", "36, augment 450 includes protrusion 452 that is flared outwardly.", "The flared protrusion 452 may be expandable when used with a central mandrel or expanding fastener.", "Additionally or alternatively, it may be made from a deformable material and/or may be provided as a bifurcated member having one or more leg portions to facilitate expansion of the protrusion.", "The outer peripheral surface portions 453 of the protrusion 452 may be rounded (e.g., a frustoconical shape), and the augment 450 (or, in some embodiments, mounting member) may not only be translated within and along the track 462 on the shell 460, but also rotated within the track 462 on the shell 460.A fastener 456 such as a screw, setscrew, mandrel, shank, rivet, or any other fastener having a low profile head which is accessible from the inside dome portion of the shell or cage 460 (or another augment) is configured to engage an inner bore or opening 458 located in the flared protrusion 452, thereby expanding the protrusion 452.The term “expansion member” is used herein to refer to any appropriate member, including but not limited to the fasteners listed above, that can be used to engage and/or otherwise expand another feature.", "One example of an expansion member that may be used in connection with this embodiment comprises a setscrew/mandrel/fastener that has a tapered outer portion or a surface having an outer diameter that is greater than the receiving portion of the protrusion, such that when the expansion member is threaded into the protrusion, the protrusion expands.", "The expansion of the flared protrusion causes the protrusion to frictionally engage the track in the shell/cage/augment, thereby forming a locked dovetail connection which secures the mounting member or augment to the shell.", "Once the expansion member is completely tightened, the mounting member or augment is locked to the shell/cage/augment in both translation and rotation with a strong dovetail locking joint.", "For example, augment 450 can be attached to the track 462 by the protrusion 452.Before tightening the protrusion 452, the augment 450 can be rotated with respect to the shell 460, such that the augment interior surface 454 and the shell exterior surface 469 remain generally interfaced while the augment 450 rotates about the shell 460 like a cam, until the augment 450 is in the desired position.", "The protrusion 452 is then tightened to secure the augment 450 in that position.", "One advantage of such a mechanism is that the assembly of the shell/cage/augment and the mounting member or augment may be loosely assembled, then placed into a bone void such as an irregularly shaped bone void.", "Once generally positioned, the assembly components may be adjusted with respect to each other to best fit an existing or prepared bone void.", "The assembly components may then be tightened together such that the assembly closely approximates the size, shape, and orientation of the existing or prepared bone void.", "While the particular embodiment shown in FIG.", "36 illustrates an expansion member 456 seated in a “blind” interior opening or bore 458 in augment 450, an augment may alternatively or additionally comprise a through hole such as through hole 478 of augment 470 in FIG.", "39, configured to receive an expansion or tightening member 476, for example a long bone screw, long fastener, or other long expansion member (such a tightening configuration will be referred to throughout as a “long bone screw,” but it will be understood that any appropriate fastener that can secure two components together, while also potentially gain purchase into bone is considered appropriate for use in connection with the described embodiment).", "The tightening member 476 may be configured to gain purchase in the augment 470 and/or surrounding bone as illustrated in FIG.", "39.The opening 487 in the flared protrusion 472 that receives the bone screw 476 may generally continue through the augment 470 and out a hole 479 in a side of the augment 470 opposite the protrusion 472.In such embodiments, the bone screw 476 enters the augment 470 through an opening in the track 462 on the inside surface 463 of the shell/cage 460 (or, in some embodiments, another augment), and protrudes through the entire augment 470, including the flared protrusion 472 which, during insertion of the bone screw 476, will expand into the undercut track 461 on the shell/cage 460.Essentially, the bone screw 476 locks the augment 470 to the shell/cage 460 and secures the entire assembly to surrounding bone, thereby stabilizing the assembly with respect to hip anatomy.", "In this sense, not only does the bone screw 476 serve to rigidly secure the augment 470 to the shell/cage 460 before necessarily securing purchase of the bone screw 476 into surrounding bone, the bone screw 476 further provides secondary fixation of the assembly to surrounding bone by then subsequently securing purchase with surrounding bone.", "The embodiment shown in FIG.", "39 allows a surgeon to lock the augment 470 to a second component from an inside portion (e.g., an inside portion 463 of a shell 460), after the loose assembly is placed into the prepared bone void.", "In other words, the augment 470 may be loosely coupled to the shell 460 or other second component in the patient's bone void, and a fastener is used to secure the augment to the second component (not shown, but which may be the shell, cage, or a second augment) and to the patient's bone.", "The head is arranged within the slot of track 462 so that it is aligned with the interior opening 478 of the augment 470 and extends radially within the shell 460.The surgeon can then insert a tightening rod through the interior opening 478, from inside the shell 460, to access and tighten the screw 476.FIG.", "40 illustrates some embodiments related to those shown in FIG.", "39.A bone screw 681 or other fastener having both an expanding portion 694 and a bone engaging portion is inserted through an undercut recess, groove, or track 682 provided on an acetabular shell or cage 680 (or, in some embodiments, provided on an augment).", "The bone screw 681 or other fastener may be inserted from an accessible inside portion 683 of said shell/cage 680.The bone screw 681 or other fastener protrudes into and through an opening 684 within an adjacent augment 686 (or, in some embodiments, a mounting member) having a male connection member 688.The male connection member 688 may be generally cylindrical or flared (e.g., frustoconical) and is configured to be inserted into and move within (translate, rotate, etc.)", "the undercut recess, groove, or track 682.In use, as the bone screw 681 begins to make purchase with bone, the expanding portion 694 of the bone screw 681 engages a complementary expanding portion 692 of the augment 686 adjacent the male connection member 688, thereby expanding a portion of the male connection member 688 inside the undercut recess, groove, or track 682 and locking the augment 686 to the shell/cage 680 (or other augment).", "In some embodiments, one or more of the expanding portions of the bone screw and mounting member or augment may not be threaded.", "For example, the expanding portion 694 of the bone screw 681 may be threaded, and the expanding portion 692 of augment 686 may be a smooth tapered recess.", "Alternatively, the expanding portion 694 of the bone screw 681 may be a smooth tapered surface that seats within and wedges against a smooth tapered expanding portion bore 684 in the augment 686.The taper angle of the bone screw 681 expanding portion 694 may differ from the taper angle of the expanding portion bore 684.Furthermore, the expanding portion 694 of the bone screw 681 may be an enlarged threaded section that engages with a smooth undersized bore 684 in expanding portion 692 of the augment 686.In further embodiments, as shown in FIGS.", "41 and 42, it may be desirable to secure a mounting member or augment to an acetabular shell or cage, or other augment or mounting member prior to insertion into a prepared acetabular bone void.", "In such instances, the expansion member used to expand the protrusion may be made relatively shorter, so as to be partially or completely encased by the mounting member or augment.", "For example, expansion member 486 of augment 480 and expansion member 496 of augment 490 may be relatively shorter than bone screw 476 of augment 470.The insertion direction of the expansion member may be reversed with respect to the aforementioned embodiments, and move in a securing direction which is towards the acetabular shell/cage or other augment.", "In this way, the mounting member or augment may be attached to the shell/cage or other augment in a predetermined configuration, prior to insertion of the assembly into the prepared bone cavity.", "The embodiment shown in FIG.", "41 allows a surgeon to lock the augment 480 to the shell 460 prior to insertion into the prepared bone void, outside of the body cavity.", "The attachment prior to insertion may be a tight securement or a loose coupling.", "If a loose coupling is desired, such that complete securement can be completed once the assembly has been fully positioned, an opening 499 on an upper surface 494 of the augment 490, as shown in FIG.", "42 allows tightening once the completed assembly is positioned in the bone cavity.", "In other words, this embodiment allows a surgeon to lock the augment 490 to the shell 460 from an outside portion on exterior surface 469 of the shell 460, after the loose assembly is placed into the prepared bone void.", "In use, the surgeon may place a frustoconical or otherwise flared protrusion of the mounting member or augment into an insertion clearance opening in the shell/cage or other augment, and then may move the augment within a track extending from and connected to the opening (as shown in FIG.", "43) to a desired rotational angle and/or location along the track.", "The surgeon may rotate, translate, or otherwise position or move the mounting member or augment as desired within the track.", "When the augment is positioned and located in a desired spatial orientation relative to the shell/cage or other augment, the expansion member can be inserted into and through the augment, and tightened within a threaded bore located in the protrusion.", "It will be appreciated by one having ordinary skill in the art that, while not shown, the expansion member may be internally threaded and engageable with a male thread located within an opening in the protrusion.", "It will also be appreciated that, while not shown, the expansion member may only threadingly engage the bulk body of the mounting member or augment and may have a distal wedge portion provided thereon which engages a smooth tapered opening in the protrusion.", "In this embodiment, when the expansion member moves toward the protrusion in threaded engagement with the bulk body of the mounting member or augment, its distal wedge portion wedges open the flared projection via inclined surfaces without actually “threadably” engaging in inner surface of the protrusion.", "It should also be noted that the use of other fasteners such as the rivet-type, or any other suitable fastener, or combinations thereof, is envisioned.", "When the expansion member is tightened or otherwise adjusted, the arms of the bifurcated protrusion expand and move away from each other, and therefore, the outer flared portions of the protrusion engage the undercut walls of the track provided on the shell/cage/augment.", "For example, when expansion member 456 of FIG.", "36 is tightened or otherwise adjusted, the arms of protrusion 452 may expand and engage the undercut walls 461 of the track 462 provided on shell 460 of FIG.", "37.The arms of protrusions 472, 482, and 492 may similarly be expanded when an expansion member is tightened or otherwise adjusted.", "Friction between the walls of the track and the expanded bifurcated protrusion maintain the mounting member or augment in fixed relationship relative to the shell/cage/augment, and the assembly may be inserted into the prepared bony site.", "As shown in FIG.", "43 and for potential use in connection with or interchangeably with the embodiments shown in FIGS.", "79-82, an intermediate adapter member may be used to secure a mounting member or augment to an acetabular shell, cage, or other augment.", "For example, adapter 502 comprises a portion that is received in an opening (e.g., tapered hole or undercut track) in the shell/cage/augment, and sits flush or recessed with respect to an inner surface of the shell/cage/augment, so as to not protrude into the inside portion of the shell/cage/augment where a liner might be seated.", "The adapter 502 may have an expanding tapered or flared head 504 (e.g., frustoconical) that protrudes outwardly from the shell and engages an undercut slot, blind or through-slot, or a tapered aperture in the mounting member or augment.", "For example, adapter 502 includes an expanding tapered or flared head 504 that engages undercut slot 508 of augment 500.The adapter 502 may be entirely or partially cannulated and may be non-threaded, threaded partially, or threaded all the way through its length.", "The expanding tapered or flared head 504 of the adapter 502 may be made bifurcated so as to have two or more arm portions 505 and 506 that are configured to move away from each other to expand the head 504 and create a locking interference between the expanding head 504 and the undercut slot or tapered aperture 508.A small expansion member 510, a long bone screw (not shown), or any other suitable fastening member may be threadably received in the adapter 502 such that when the expansion member 510, long bone screw, or other fastening member threads into the bifurcated head portion 504, the arms 505 and 506 of the head portion 504 expand and frictionally engage the walls of the slot or aperture 508 to lock augment 500 to the shell/cage 600 or other augment.", "A mounting member may similarly locked to an acetabular shell or cage 600 or an augment.", "The head 512 of the expansion member 510, long bone screw, or other fastening member may lie flush with, or slightly recessed from the inside (e.g., concave) surfaces of the shell/cage/augment, so that a liner may be properly seated.", "FIG.", "44 shows an insertion opening 516 in a shell 518 adapted to receive features of the adapter system of FIG.", "43 according to some embodiments.", "FIG.", "45 shows a side cross-sectional view of an adapter 520 in place within the shell 518 and an augment 522, used to secure the two components to one another.", "As shown, the adapter 520 may have a frustoconical head 524, and specifically, may have a head 524 that is bifurcated and expandable.", "The head 524 of the adapter 520 may be received in an augment 522 or any other first component (e.g., a mounting member) that is desired to be coupled or otherwise secured to a second component (e.g., an acetabular shell or cage).", "The augment 522 may have a J-slot (e.g., as shown in more detail in FIG.", "43), a dovetail configuration, or may have any other appropriate shape, such as an undercut design, or any other appropriate track-type slot or groove.", "This feature may extend to the upper edge of augment 522 or first component (e.g., as shown in FIG.", "43 where slot 508 extends to upper surface 514 of augment 500) or it may be positioned in the side wall only of the augment 522 or first component (e.g., as shown in FIG.", "37 where track 462 is provided through surfaces 463 and 469 of shell 460).", "In use, the adapter head 524 slides into or is otherwise positioned in the slot/track/undercut.", "The adapter tail end 526 may extend slightly from the augment 522 or first component and extend toward and slightly into an insertion opening in the shell 518 or second component.", "As discussed above and shown clearly in FIG.", "45, it is preferable that the adapter tail 526 not extend completely into the internal cavity of the shell 518 or second component so that a liner 528 may be used without having the liner 528 directly abut or otherwise contact the adapter 520.Once positioned, an expansion member 530 is inserted into the adapter 520 to cause the bifurcated head 524 to expand and lock, plug, or otherwise securely lodge the adapter 520 in the desired location.", "FIGS.", "46 and 47 illustrate an example of a prior mounting member or augment 531 adapted for securement to a shell 533 as disclosed in U.S. Patent Application Publication No.", "2007/0093133, entitled “Fixing Assembly,” which is incorporated by reference herein in its entirety.", "FIGS.", "48-50 illustrate various embodiments of an improvement of the devices shown in FIGS.", "46 and 47.A mounting member or augment may be provided with an opening having multiple fixed directional threaded screw holes.", "For example, mounting member or augment 540 of FIG.", "48 includes an opening 542 having a plurality of fixed directional threaded screw holes 544.In the specific embodiments shown, there are three fixed directional threaded screw holes (e.g., screw holes 544), but it will be understood that more or fewer holes may be provided.", "The holes may be fixed in various orientations in space with respect to each other.", "The holes may be spaced apart from each other as shown by holes 546 in FIG.", "50.The holes may intersect radially as shown by holes 544 in FIG.", "48.The holes may be positioned linearly as shown by holes 548 in FIG.", "49.In use, a protrusion member that extends from a mounting member or augment is received in rotating engagement by a round blind undercut recess on an acetabular shell, cage, or augment as shown in FIG.", "46.Alternatively, the protrusion member may be received in an undercut track (e.g., as shown in FIGS.", "37 and 38) provided on an acetabular shell, cage, or augment.", "As shown, the projection may be bi-forked in configuration to facilitate its expansion when one or more screws or other fastening members are inserted through one or more of the threaded screw holes in the mounting member or augment.", "The protrusion on the mounting member or augment is generally configured to expand upon partial screw insertion and is also generally configured to secure and lock the mounting member or augment to the shell/cage/augment in a desired relative spatial orientation, regardless of whether or not the screw secures purchase within the bone.", "FIG.", "51 illustrates a mounting member or augment 550 according to certain embodiments that may be used for coupling to an acetabular shell, cage, or other augment having a round blind undercut on the shell, one example of which is shown in FIG.", "46.Alternatively, as previously mentioned, the protrusion member 552 may be received in an undercut track (e.g., as shown in FIGS.", "37 and 38) provided on an acetabular shell, cage, or augment.", "As shown in FIG.", "51, an expandable or deformable spherical ball member 554 is adapted to be positioned within, located inside, or otherwise captured within an opening 558 in a split or bifurcated mounting member or augment 550 and captured therewithin.", "The ball member 554 may be undersized so as to expand when an expansion member (e.g., screw 556) or other fastener is inserted therein.", "Alternatively, the ball member 554 may be formed of a deformable material to allow the ball 554 to expand upon insertion of an expansion member (e.g., screw 556) or other fastener.", "Moreover, the ball member 554 may be split to facilitate expansion of the ball member 554.The ball member 554 is generally captured within, secured to, or otherwise operable with the mounting member or augment 550 so as to form a ball joint.", "The ball member 554 may have a deformable smooth bore which is ultimately deformed to be threaded by the screw fastener during insertion.", "Alternatively, the ball member 554 may comprise a threaded bore which is slightly undersized in inner diameter with respect to the inserted screw.", "Alternatively, the bore in the ball member 554 may be smooth and the ball member 554 expanded when engaged by an expansion member or other fastener.", "In some instances, as shown, a screw 556 or other fastener may be provisionally positioned adjacent an aperture of the cannulated ball member 554, and then oriented to a desired spatial location and angulation with respect to a patient's anatomy for insertion into adjacent pelvic or other bone.", "The expansion member (e.g., screw 556), long bone screw, or other fastener may be used as a lever to move the ball 554 at any angle relative to the mounting member or augment 550 and then inserted to secure bone purchase.", "When the screw or fastener 556 passes through the aperture in the ball 554, the ball 554 spreads open or deforms via the aforementioned undersized, deformable, or expandable means.", "In this instance, the ball 554 expands, and in turn, also further expands the mounting member or augment 550, which may be bifurcated, one example of which is described above.", "When the mounting member or augment 550 is expanded, the protrusion member 552, shown here as a generally flared and bifurcated frustoconical projection, expands within and may lock into a round, blind undercut recess or undercut groove in the shell/cage/augment in the desired angular spatial orientation.", "The mounting member or augment 550 is generally configured to allow fixing of itself to the shell/cage/other augment regardless of whether or not the screw 556 secures purchase within the bone.", "Moreover, the ball member 554 captured within the mounting member or augment 550 also allows the screw 556 to be inserted in any orientation relative to both the mounting member or augment 550 and the shell/cage/other augment.", "In some embodiments, such as those shown in FIGS.", "52 and 53, an optional rotatable inner cylinder insert member may be used.", "The cylinder may be split along its length and may have one or more threaded bores extending along its length at one or more various angles, offsets, and eccentricities for engagement with a long bone screw or other fastener.", "For example, as shown in FIG.", "52, a single bore 566 may be provided in a cylindrical insert 564, the bore 566 having a smooth outer bearing surface 568 that is angled and offset.", "The insert 564 shown is captured within the mounting member or augment 564 by a knurl, step, flange, or lip 567 so as to be rotatable with respect to the mounting member or augment 560, but not axially displaceable from the mounting member or augment 560.When the screw or fastener 569 is inserted into the bore 566, the insert 564 expands, and in turn, expands a projection member 562 on the mounting member or augment 560 or alternatively or additionally expands the entire mounting member or augment 560.The projection member 562 may expand within the round blind undercut on the shell, cage, or other augment shown in FIG.", "46, or alternatively may expand within an undercut groove within said shell, cage, or other augment as shown in FIGS.", "37 and 38.FIG.", "53 depicts a mounting member or augment 570 that is similar to the embodiment shown in FIG.", "52, but instead, is configured for use with a polyaxial screw or fastener 576 having a smooth rounded head 577.In this exemplary embodiment, the inner cylindrical insert 574 is not split, but is instead provided as a larger diameter, externally-threaded body configured to be received in a smaller diameter threaded bore 571 in the mounting member or augment 570.The inside of the cylindrical insert 574 has one or more “hourglass”-shaped bores 578, for instance, those that can be used with polyaxial screw heads having rounded or spherical screw heads.", "Various examples of polyaxial locking systems and methods are shown and described in U.S. Patent Application Publication No.", "2002/0147499, entitled “Locking Systems for Implants,” U.S. Patent Application Publication No.", "2008/0300637, entitled “Systems and Methods for Using Polyaxial Plates,” and U.S.", "Provisional Patent Application No.", "61/178,633, entitled “Polyaxial Fastener Systems and Methods,” all of which are intended for potential use in connection with the described systems and are incorporated by reference herein in their entireties.", "The bore 578 may comprise portions engageable with threads of the polyaxial screw 576, or may contain deformable tabs in regions proximate the head 577 for use with threaded heads.", "The angle of the screw or fastener 576 can be varied within the bore 578 of the cylindrical insert 574.Regardless of whether or not the polyaxial screw 576 is inserted into the bore 578, the mounting member or augment 570 is positively secured and locked to the shell/cage/augment in a desired spatial orientation and angulation due to the expansion of the projection member 572 or the mounting member or augment 570 as a whole.", "This occurs, for example, after inserting and threadably engaging the cylindrical insert 574 with an undersized threaded recess (e.g., bore 571) provided in the mounting member or augment 570.FIGS.", "54-70 show certain embodiments for attaching mounting members or augments to an acetabular shell, acetabular cage, or other augment.", "Disclosed is an apparatus and method for attaching the acetabular mounting members or augments to shells, cages, and other augments with an amount of adjustability.", "A kit of different augments may be provided for use with the same acetabular shell, cage, or augment.", "Relative spatial adjustments between the mounting member or augment position and the shell/cage/augment may be made with multiple degrees of freedom.", "The mounting members and/or augments may be attached and subsequently permanently and irremovably secured and locked to the shell/cage/augment prior to or after its insertion into a prepared acetabulum and/or surrounding bone voids.", "In certain embodiments shown in FIG.", "54, a mounting member 580 or augment member 582 is provided with a dovetail feature 581 and 583 (that may be male or female), respectively, to connect it to an acetabular shell or cage 584 (or, in some embodiments another augment) having the other complementary mating female or male dovetail feature 586.In the embodiment shown, the complementary feature 586 on the shell 584 is a J-shaped track or J-slot, but it will be understood that any mating features or configurations may be used.", "In the specific embodiment described, the dovetail feature 586 is configured to allow the mounting member 580 or augment member 582 to rotate and/or translate with respect to the shell 584 in a semi-locked state.", "The semi-locked state generally allows some independence of movement between the two pieces, which can be desirable to allow a surgeon to toggle between relative positions or otherwise continue to position and adjust the members.", "Such a semi-locked or loose connection can be particularly useful for revision surgeries.", "The mounting member 580 or augment member 582 may be provided in a number of various shapes, sizes, textures, and configurations configured to fill bone defects and voids of varying degrees and locations with respect to a patient's anatomy.", "For instance, an implant may comprise a flange member that does not necessarily serve to fill a bone void/defect, but is instead configured to couple with a bone surface.", "Dovetail features according to FIGS.", "54-70 generally mate by providing a flared male member (e.g., member 581 or 583) that is configured to slidingly engage one or more complementary female members such as one or more separated or intersecting undercut grooves or recesses (e.g., member 586).", "The undercut grooves or recesses may be provided on either component or vise versa, without limitation.", "A third member, for example an expansion member (e.g., setscrew, fastener, rivet, wedge, pin, cam, long bone screw, or any other fastener), may further be provided and used to securely lock the two pieces together to form a locked assembly.", "In some instances, the third member will engage one or more portions of the dovetail features to cause the male member to expand in the female member.", "In other instances, for example, as shown in FIGS.", "55 and 56, a fastener such as a setscrew may be inserted through a male portion 588 of the dovetail features to move the male member 588 away from a blind portion of the female member 589, thereby spreading the two pieces such that tapered surfaces of the dovetail features frictionally engage each other.", "FIGS.", "57-61 illustrate some embodiments wherein one or more locking chocks are distally-connected to a surgical cable and are configured to be received and/or captured within a portion of a mounting member or augment.", "For example, FIGS.", "57 and 58 show a locking chock 590 distally-connected to a surgical cable 592 and positioned within a portion of augment 594.The cable 592 may be introduced through a through-bore in a mounting member or augment (e.g., bore 596 of augment 594) and tightened via a clamping device.", "The chock 590 is shaped to complement a tapered hole or an undercut groove or recess provided in an acetabular shell, cage, or other augment (e.g., undercut recess or groove 602 of FIG.", "59).", "When the surgical cable 592 is tightened around the mounting member or augment adjacent bone or to any other plating structures, the chock 592 is pulled toward the undercut surfaces of the tapered hole undercut groove/recess and is expanded by an expansion member 598, for example, by a ball crimped to a distal portion of the surgical cable or any of the other expansion members described herein.", "The chock 590 may engage the undercut groove or recess.", "As shown in FIGS.", "59 and 60, an internal portion of a chock 604 may have an angled or inclined surface 600, which is adapted to receive an expansion member 606.In use, the chock rides along the cable and once positioning is desired, the wings of the chock may be forced apart for securement.", "For example, wings 595 and 597 of chock 590 shown in FIG.", "58 may be forced apart for securement.", "When the cable is tightened, this can (a) pull the augment towards the shell/cage/other augment and (b) pull the ball or other expansion member at the end of the cable inside the chock so that the wings will expand and the chock will be secured in place.", "For example, when cable 601 of FIG.", "59 is pulled in the direction of arrow 608, this can pull expansion member 606 inside the chock 604 so that the wings 605 and 607 of chock 604 expand, thereby securing the chock 604 in place.", "Alternatively, while not shown, the chocks may be separate pieces attached to the surgical cable at different portions and provided with inclined surfaces that ride together to facilitate expansion and frictional engagement with the tapered hole or undercut groove/recess.", "The one or more locking chocks may be oblong for easy insertion into the undercut groove or recess.", "Once the cable is pulled tight, it may be used as cerclage cable or K-wire and tightened around bone or other anatomical structures, keeping the mounting member or augment attached to the shell, cage, or other augment.", "Alternatively, as shown in FIG.", "61, the cable 610 may be tensioned using a cable tensioning device provided on the mounting member or augment 614.For instance, as shown, a tensioning screw member 612 may threadingly engage a female thread 616 located in the mounting member or augment 614.As the tensioning screw member 612 is turned, the cable 610 is pulled into tension, thereby moving an expansion member (e.g., a crimped ball) against inner inclined surfaces located on the one or more locking chocks such as inclined surface 600 of chock 604.When the expansion member (e.g., expansion member 606) reaches a point of interference with the one or more locking chocks, the tensioning screw member may be turned further to spread the chocks apart and lock the mounting member or augment to the shell, cage, or other augment via a tightened dovetail joint.", "FIGS.", "62-64 illustrate some embodiments wherein a mounting member or augment 628 may be attached to an acetabular shell, cage, or other augment 629 using a separate expandable chock member 620 and an intermediate connecting member 622.The intermediate connecting member 622 serves to temporarily loosely couple the mounting member or augment 628 to the shell/cage/augment 629, and also serves to expand the separate chock member 620 and lock the two components together.", "In some embodiments, it is preferred that the separate expandable chock member 620 is provided as a generally frustoconical portion or a male portion of a dovetail connection.", "The separate expandable chock member 620 may be inserted into and captured within an undercut recess, groove, or track (e.g., undercut recess, groove, or track 624) in an acetabular shell, cage, or other augment 629.In some embodiments, the separate expandable chock member 620 is movably captured and may be positioned at various locations and orientations within said undercut recess, groove, or track.", "The mounting member or augment 628 is then placed adjacent to the shell/cage/other augment 629, and the intermediate connecting member 622 inserted through an aperture, opening, or recess 626 in the mounting member or augment 628 to engage an undersized or tapered female thread 627 in the separate expandable chock member 620.The mounting member or augment 628 may be moved to a desired position relative to the shell/cage/augment 629 by virtue of the loose connection and undercut recess, groove, or track, and then locked in a desired relative spatial orientation by engaging the intermediate connecting member.", "In the embodiment shown, the intermediate member 622 is provided as a headed bolt that threadingly engages the separate expandable chock member 620 to expand the separate expandable chock member 620.When the separate expandable chock member 620 is fully expanded, a frictional dovetail locking connection is achieved, which locks the mounting member or augment 628 to the shell/cage/other augment 629 in the desired relative spatial orientation.", "FIG.", "65 illustrates an alternative embodiment to FIGS.", "62-64, which is similar to the embodiment shown in FIGS.", "41 and 42.A small expanding element 630 is provided within an aperture, opening, or recess 632 in a mounting member or augment 634 configured to be loosely attached and locked to an acetabular shell, cage, or other augment 636.The mounting member or augment 634 includes a male portion of a dovetail.", "The male portion of a dovetail may be formed by a deformable or expandable protrusion 638 which may be bifurcated and/or initially flared outwardly in an un-deformed/unstressed state.", "Alternatively, while not shown, in some embodiments, the expandable protrusion 638 may be provided as a generally cylindrical member which can be first introduced into an undercut recess, groove, or track, and then expanded within said undercut recess, groove, or track by the expanding element in order to provide a locking function between the mounting member or augment and the shell/cage/augment.", "As shown in FIG.", "65, the expanding element 630 may be provided as a small tapered setscrew which engages a complementary tapered or otherwise undersized thread 640 inside the male portion of a dovetail.", "A flexible driver 642 may be used to access the small expanding element 630.Upon torsional engagement with the expanding element 630, a dovetail locking connection is formed, thereby securing the mounting member or augment 634 to the acetabular shell, cage, or other augment 638 in a desired configuration and relative spatial orientation.", "FIG.", "66 shows an alternate and additional feature relating to the cable and chock embodiments of FIGS.", "57-65.FIG.", "66 shows a ferrule 700 on a cable 702 that may be positioned against an augment 704.A tensioning tool 706 may be used to hold the cable 702 tight and the ferrule 700 can be crimped onto the cable 702.When the cable 702 is pulled tight, the chock (e.g., chock 590 of FIG.", "57) engages the dovetail slot and the tension pushes the chock towards or into the augment 704, held in place by the ferrule 700.FIG.", "67 shows one potential geometry for a receiving portion 650 (such as an undercut recess, groove, or track) in a shell, cage, or augment according to some embodiments.", "In this example, the receiving portion is a double J-slot formed by slots 652, 654, and 656.FIG.", "68 shows a further optional geometry, where J-slots are provided in opposing directions formed by slots 662, 664, and 667.As shown in FIGS.", "68 and 69, any of the mounting members or augments shown and described herein may comprise tick marks or other indicia for indicating a positional relationship between itself and the implant to which it is to be attached.", "For example, an augment 670 may comprise a plurality of peripheral markings 672 or central markings (not shown) for alignment with markings 661 provided in an acetabular shell or cage 660 (or, in some embodiments, another augment).", "In use, a surgeon may loosely insert the mounting member or augment (e.g., augment 670) and the shell/cage/augment (e.g., shell 660) into a patient's bone void, prior to assembling the two.", "The surgeon may then position both components and possibly other components to determine the best relative spatial orientation to best fill a volume of the void.", "The surgeon may then observe, compare, and note the relative positions of the markings or indicia between the bodies, thereby receiving repeatable and reproducible information about the desired spatial orientation.", "The surgeon may then remove both bodies from the surgical environment, realign them in the desired spatial orientations (facilitated by the markings or indicia), and then cement or otherwise secure the two bodies together in said desired spatial orientation.", "Subsequently, the assembled implant may be introduced into the void and the surgery completed in a normal fashion.", "Moreover, as shown in FIG.", "70, mounting members or augments shown and described in the figures contained herein may comprise tacks, spikes, coatings, or textured surfaces 674 so as to improve initial fixation.", "The geographic locations of said tack, spike, coatings, or textured surface structures 674 may be strategically placed on select portions so as to evenly load the implant assembly and obtain the best biologic response initially, and over an extended period of time.", "FIG.", "71 shows a bi-lobe cup or shell 710, which is a shell 710 having a lobe 712 extending therefrom.", "Typical bi-lobe shells are made of solid material, but this embodiment shows a bi-lobe shell 710 having a lobe 712 of porous material.", "The lobe 712 may have some solid portions for receiving screws other fastening members.", "As shown, additional augment members 714 may be attached to the lobe 712 of porous material or to the solid shell 710.Areas of the porous lobe 712 may be provided with areas of solid, non-porous material having apertures or other structures for receiving and locking to screws, such as polyaxial bone screws.", "Moreover, the porous lobe 712 may comprise holes 716 extending through fully porous sections for insertion of bone screws.", "FIG.", "72 shows two augments 720 and 722 attached together via a fastening device 724 such as a screw or a shape-memory polymer peg according to some embodiments.", "It will be understood that although augments are shown, the securement mechanisms described herein may also be used with any type of mounting member, shell, or cage as well.", "In some embodiments, a peg of shape memory material may extend from one or more augments and into a prepared hole in bony anatomy.", "The shape memory peg may then be activated (via thermal changes or an applied electric current) and expanded within the prepared hole to fix an augment or mounting member to the patient's bone.", "Non-limiting examples of further features for such shape memory plugs are that they may comprise outer textured surfaces, may be porous, and may comprise barbs, flutes, ridges, grooves, spines, any other suitable features, or combinations thereof.", "FIG.", "73 shows an augment 726 with integral spikes 728 according to some embodiments.", "The spikes 728 may allow the augment 726 to be positioned initially in bone, without the augment 726 having to be first secured to a shell, cage, mounting member, or other augment or without the use of bone cement.", "The augment 726 may be positioned and then impacted or otherwise pressed into a bone void to achieve instant fixation.", "FIG.", "74 shows other embodiments of an augment 730 having built-in securement features.", "Embodiments of this augment may have one or more integral spikes, barbs, screws, or other fasteners pre-positioned therein.", "For example, augment 730 includes integral fastener 732 which may be a spike having barbs 734.When the augment 730 is positioned as desired, the surgeon may screw, impact or tack the augment 730 in place, causing the integral fastener 732 to extend and secure bone purchase.", "One advantage of this embodiment is that is can prevent the surgeon from having to locate and insert separate fasteners.", "In some embodiments, there is provided a breakable or frangible connector 736 that is sheared once the fastener 732 has been impacted, twisted, or otherwise activated by a force or moment.", "A further advantage of the described embodiments is that the augment 730 is a one-piece component that can be positioned without additional fasteners or other components attached thereto, simplifying some aspects of insertion.", "Moreover, the surgeon may desire to place the augment 730 first, and then quickly secure it to the other implant portions to be used.", "Integral fasteners which are not utilized may be removed by a pulling out force, and breaking the connector.", "Fasteners such as integral fastener 732 may be configured to connect the augment to bone or to other implant devices such as other augments, acetabular shells, acetabular cages, and/or bone plates.", "FIGS.", "75-77 illustrate various augments or porous coating portions comprising one or more cross-sectional areas 740, 742, and 744 of reduced material which are “designed” for easy drilling, shaping, and screw insertion.", "In some embodiments, a bulk porous structure is provided with waffle patterns of recesses defined therein.", "The recesses may be externally provided, internally provided, or combinations thereof.", "External recesses may be created using rapid manufacturing, wire EDM, milling, or other processes.", "Internal recesses may be created using rapid manufacturing (e.g., selective laser sintering with an EOS machine or EBM process using an Arcam machine), cross-drilling processes, any other suitable processes, or any combinations thereof.", "The areas of reduced cross-section 740, 742, and 744 make it easier for a surgeon to drill through the augments or porous coating portions, orient screws, and burr, mill, cut, break, bend, or otherwise shape with a rotary tool 746 such as the one shown in FIG.", "78.Other modification tools such as reciprocating saws or oscillating saws may be utilized to shape the augments or porous coating portions.", "Recesses may extend in various patterns in two-dimensional or three-dimensional space, and may vary in width, depth, aperture, thickness, density, and length.", "FIGS.", "79-82 illustrate some embodiments of a connection device for securing a mounting member or an augment to an acetabular shell or acetabular cage.", "Certain embodiments of the connection device comprise an intermediate locking member 750 that may be placed between an acetabular shell or cage and a mounting member or augment, the intermediate locking member 750 configured to provide initial loose and adjustable attachment of the mounting member or augment to the acetabular shell or cage.", "After or before impaction, the mounting member or augment position relative to the shell or cage may be adjusted and then fixed with respect to the shell or cage by engaging a portion of the intermediate locking member 750.After the intermediate locking member 750 is engaged to lock the adjacent components together against relative movement, a liner may be inserted into the shell or cage.", "The intermediate locking member 750 may either be a separate portion or integral to one of the shell, cage, mounting member or augment.", "Portions of the intermediate locking member 750 may be low profile and configured to be received in and locked within an acetabular shell (e.g., via a threaded, smooth, or tapered screw hole).", "In the embodiment shown, the intermediate locking member 750 is provided within an acetabular shell as disclosed in the '705 application.", "Intermediate locking member 750 may comprise, as shown, a cam locking pin 752 and a locking head screw 754.The mounting member or augment may comprise an undercut recess 759 which has an opening of any appropriate shape, such as oblong, scalloped, triangular, dovetail, or any other option.", "A distal end 756 of the cam locking pin 752 has a complementary shape (oblong, scalloped, triangular, dovetail, or any other appropriate complementary shape) and is flared or tapered radially outwardly to engage one or more undercut surfaces forming the undercut recess 759.As shown in FIGS.", "80 and 81, a proximal end 757 of the cam locking pin 752 may have a shaft 758 with engageable threads axially-disposed therein.", "A locking head screw (shown for example, as locking head screw 754 of FIG.", "82) is configured to engage the threads on the shaft 758 of the cam locking pin 752.The threads of the locking head screw may be female or male, and the threads of the cam locking pin 752 may be the other of male or female.", "Locking screws prevent the cam locking pin 752 from backing out once properly positioned.", "During use, the cam locking pin 752 is positioned within a receiving groove or recess and rotated to lock the cam locking pin 752 in place.", "The complementary shapes of the distal end 756 of cam locking pin 752 and a receiving groove or recess allow the cam locking pin 752 to be inserted into the groove or recess in a first orientation and then rotated to a second orientation in which it cannot be removed from the groove or recess.", "The shaft portion 758 of the cam locking pin 752 may be provided with one or more flats on the outside (e.g., a hexagonal outer cross section for the shaft) to allow turning of the cam.", "Alternatively, a cruciform recess or hexagonal recess or other driving structure may be provided on the cam locking pin 752.In some embodiments, the female thread in the cam locking pin 752 may be substituted for threads on the outside of the shaft 758 of the cam locking pin 752 which engage a partially cannulated locking screw having an internally-threaded aperture extending axially through the shaft of the locking screw.", "In such latter embodiments, outer portions of the locking screw may be smooth.", "The head 755 of the locking head screw 752 may alternatively be rounded for polyaxial movement (exemplary polyaxial locking options are provided in more detail below) within the hole in the acetabular shell or cage.", "It will be understood by those of ordinary skill in the art that the connection shown in the figures may also be used to connect augments or mounting members together, without limitation.", "FIGS.", "83-85 illustrate some embodiments wherein a mounting member or augment, for example, as disclosed in FIGS.", "79-82, is provided with an elongated undercut groove which is configured to receive a cam locking pin.", "The elongated undercut groove allows the mounting member or augment to be radially adjusted in space and locked in an orbital position around a corresponding acetabular shell or cage.", "In some embodiments, portions of the mounting member or augment proximate the elongated groove may be made solid, rather than porous for strength, and outer regions of the mounting member or augment may be smooth, textured, coated (e.g., hydroxyapatite), porous, or combinations thereof in order to encourage biologic fixation and ingrowth in select regions.", "FIG.", "84 illustrates a cross-sectional view of an augment 764 and a cam locking pin 752 being inserted into an elongated undercut groove 768 of the augment 764 in an insertion position.", "The cam locking pin 752 is positioned into the groove 768 by rotating the cam locking pin 752 along its axis such that the insert width 762 of the distal end 756 of the cam locking pin 752 (as shown in FIGS.", "79-81) fits through the insert width 770 of the elongated undercut groove 768.FIG.", "85 illustrates a cross-sectional view of the augment 764 with the cam locking pin 752 locked into the elongated undercut groove 768 of the augment 764 in a locking position.", "In the locking position, the cam locking pin 752 may generally be rotated along its axis between 50 and 130 degrees, preferably around 90 degrees (i.e., a “quarter-turn”).", "The locking width 760 prevents the distal end 756 of the cam locking pin 752 from fitting through the insert width 770 of the elongated undercut groove 768.In some embodiments, cam locking pin 752 may be symmetrical and may have a flared end (e.g., distal end 756) comprising a generally frustoconical surface, and the undercut groove 768 in the augment 764 (or, in some embodiments, an undercut groove in a mounting member) may have one or more enlarged openings to receive the flared end of the cam locking pin 752.In such alternative embodiments, a locking screw (e.g., locking head screw 754 of FIG.", "82) may threadingly engage the cam locking pin 752 to apply a tensile force to the cam locking pin 752 against another implant such as a mounting member, augment, shell, or cage.", "In the embodiments shown in FIGS.", "86-89, cleats may be provided proximate to a rim of an acetabular shell, cage, mounting member, or augment.", "For example, in some embodiments, one or more cleats 780 and 781 may extend or project from a superior aspect of a rim portion 782 of an acetabular shell 784 as shown.", "Cleats 780 and 781 may be used to secure soft tissues to the acetabular shell 784 or may serve as a means to attach secondary augments or any type of mounting member 786 to the acetabular shell 784.In the particular instance shown in FIGS.", "88 and 89, a “quarter-turn” fastener connector arrangement is utilized.", "The quarter-turn fastener arrangement may comprise, for instance, a generally T-shaped male member 790 located on one or more regions of an acetabular shell, cage, or augment, and one or more complementary female members 792 located on more secondary augments or mounting members.", "The one or more secondary augments or mounting members engage the one or more male members 790 on the acetabular shell, cage, or augment in one degree of rotation, and then are rotated by a specified or variable number of degrees (e.g., 90 degrees) to lock the one or more secondary augments or mounting members to the one or more male members 790.Of course, one of ordinary skill in the art would appreciate that the male and female members could be reversed to provide the same function.", "It should also be understood that other locking mechanisms may be used.", "FIG.", "90 further depicts one or more cleat portions 794 located at various portions of an acetabular shell or cage 796 (or, in some embodiments, an augment) configured for securing soft tissues.", "The one or more cleat portions 794 can be arranged in any particular fashion around the acetabular shell 796; however, it is preferred that the cleats 794 extend proximally from a rim portion or otherwise away from the acetabular shell 796 in order to provide clearance from liner-mating surfaces, cement mantle surfaces, bone contacting surfaces, and bony anatomy, for example.", "Cleat portions 794 may comprise suturing holes, roughened surfaces, clamps, hooks, or biologic coatings, or any other appropriate protrusions, or combinations thereof, to encourage fixation of the soft tissues to the implant (e.g., acetabular shell 796).", "For example, as shown in the inset of FIG.", "55, sutures may be wrapped around cleat portion 794 and then secured to surrounding soft tissues.", "FIGS.", "91-95 illustrate embodiments wherein a mounting member 802 or an augment 804 may be attached peripherally to an acetabular shell or cage 806 via a recess 800 provided proximate a rim portion 808 of the acetabular shell or cage 806.The recess 800 is sized to accept a protruding insertion portion 810 of the mounting member 802 or a protruding insertion portion 812 of the augment 804, and the recess 800 may extend annularly circumferentially around the rim portion 808 to allow orbital placement of the mounting member 802 or augment 804 around a periphery of the shell or cage 806.The mounting member 802 or augment 804 may be inserted into the acetabular shell or cage 806 before or after shell/cage impaction or cementing into a prepared acetabulum.", "One or more screw holes in the mounting member (e.g., screw holes 814) or augment (e.g., screw holes 816) rigidly secure the mounting member 802 or augment 804 to the bone and prevent orbital movement of the mounting member 802 or augment 804 around the shell or cage 806.Screw holes 814 and 816 may include conventional holes, locking holes, or slots.", "The holes may be threaded, unthreaded, or partially threaded, and may be fixed or polyaxial.", "In some embodiments, screw holes 814 and 816 may include variable low-profile holes that allow for locking at a variety of angles.", "Once the mounting member 802 or augment 804 is positioned, the cantilever force pushes the rim 808 of the shell or cage 806 toward bone.", "The protruding insertion portion of the mounting member (e.g., portion 810) or augment (e.g., portion 812) provides a hold-down force to the shell or cage 806 after a screw is inserted through the mounting member 802 or augment 804 and into surrounding pelvic bone.", "FIGS.", "91 and 92 show an augment 804 being positioned with respect to an acetabular shell or cage 806.FIGS.", "93 and 94 illustrate a mounting member 802 being positioned with respect to an acetabular shell or cage 806.The mounting member 802 is shown as having multiple securing holes 814 for use with fasteners.", "Securing holes 814 may be smooth, tapered, or threaded and may be used with any appropriate fastener, including but not limited to polyaxial screws.", "The securing holes 814 through the mounting member 802 (or securing holes 816 through the augment 804) may be positioned at any appropriate angle, as shown, such as parallel to the member, oblique through the member, or otherwise as desired.", "While not shown, a honeycomb feature may be placed on outer portions of the mounting member 802 or augment 804 to provide spacing for a cement mantle between the mounting member 802 or augment 804 and surrounding bone.", "Moreover, porous structures, textured surfaces, biologic coatings, or orthopedic meshes may be integrally provided on, or incorporated between outer surfaces of the mounting members 802 or augments 804 and surrounding bone.", "In the embodiments of FIGS.", "93 and 94, a recess 800 in the shell or cage 806 is defined by a proximally-extending lip 818 such that the mounting member 802 will sit on bone surrounding the acetabulum.", "In this way, the mounting members 802 will not interfere with the press-fit area between the shell 806 and prepared acetabulum adjacent the acetabular rim 808.Moreover, because the connection is configured to allow mounting members 802 to sit on surrounding bone, the surrounding bone does not need to be countersunk or otherwise prepared to receive mounting members 802.FIG.", "95 depicts an acetabular shell or cage 820 comprising an annular protrusion 822 along a rim portion 824 of the acetabular shell 820.The annular protrusion 822 may extend partially around (as shown) or entirely around the circumference of the acetabular shell 820, or one or more protrusions may be provided in any fashion around the acetabular shell 820.The annular protrusion 822 may comprise an annular lip 826 defining an annular undercut groove 828 running circumferentially around the acetabular shell 820 proximate the rim portion 824.The annular protrusion 822 may comprise one or more openings 830 for receiving sutures (e.g., for soft tissue or capsule re-attachment) or fasteners 832 such as set screws for contacting and frictionally engaging surfaces (e.g., divots) provided on protruding insertion portions 834 and 836 of mounting members 840 or augments 838 alike.", "Fasteners 832 may be inserted into openings 830 located circumferentially laterally of the insertion portions 834 and 836 to serve as stops for preventing or limiting rotational movement of the attached mounting members 840 or augments 838.The mounting members 840 or augments 838 may be secured down to surrounding bone after being inserted into the annular undercut groove 828 via long bone screws, thereby providing a hold-down force to the acetabular shell or cage 820.The hold-down forces provided may complement the press fit, threaded fit, or cemented fixation between the acetabular shell or cage and surrounding prepared acetabular bone.", "In the instance shown, shell 820 is provided as a “hooded” shell similar to a cage, and may act as a buttress for a cemented or pressed-in liner to support various liner inclinations in varying degrees of acetabular or pelvic degradation, although it will be understood that these features may be provided on any other type of shell or cage.", "In the embodiments shown in FIGS.", "25-28, one or more mounting members and/or augments may be integrally provided with orthopedic mesh to define one or more mesh mounts or void fillers.", "FIG.", "25 shows a mounting member 380 having an orthopedic mesh 382.In FIG.", "26, the orthopedic mesh portion 382 may be placed on an outer portion 384 of the shell 386 between bone, and a cement mantle can fill between the mesh 382.The cement mantle rigidly connects the mounting member 380 (or, in some embodiments, an augment) to the shell 386 via the surgical mesh 382.Rapid manufacturing techniques may be used to simultaneously create the mounting members or augments integrally with the orthopedic mesh portion.", "The mesh 382 may be honeycomb, diamond, or other weave pattern, or any combination thereof, and may come in multiple thicknesses.", "Mesh portion 382 may be oversized, customized for an individual patient, and/or standardized and trimmed by the surgeon to fit a particular patient's needs.", "Fasteners of all types may be inserted through one or more cells of the mesh 382, as well as through the one or more mounting members or augments to further secure the implant to bony anatomy.", "For example, as shown in FIG.", "25, a first screw 388 may be inserted through cell 390, and a second screw 394 may be inserted through one of the plurality of screw holes 392 of mounting member 380.Screw holes 392 may include conventional holes, locking holes, or slots.", "The holes may be threaded, unthreaded, or partially threaded, and may be fixed or polyaxial.", "In some embodiments, screw holes 392 may include variable low-profile holes that allow for locking at a variety of angles.", "Soft tissues may be reattached using the porosities of the mesh 382 as suture anchors, or simply as a bioscaffold.", "If desired, preformed trim lines may be provided by forming predetermined frangible portions in various areas of the mesh, in order to help configuration of the device for a particular patient.", "For example, as shown in FIG.", "27, mesh 400 includes a plurality of trim lines 402 that may be cut to separate the mounting members attached thereto, such as mounting members 404.The separated mounting members 404 and the mesh 400 may then be placed into a patient's hip region 406 as shown in FIG.", "28.FIGS.", "29 and 30 illustrate some embodiments of a honeycomb design that may be provided on a mounting member or augment in order to control cement mantle thickness and spacing between said mounting member or augment and an adjacent acetabular shell, augment, bone, or other implant.", "For example, mounting member 410 of FIG.", "29 includes honeycomb portion 412 provided on an attachment surface portion 414 of the mounting member 410.The honeycomb feature 412 may be provided as any desired geometric shape.", "The mounting member 410 (or, in some embodiments, the augment) may comprise one or more securing holes 416 for receiving a surgical fastener 418 such as a polyaxial screw, cancellous screw, peg, or other securing device.", "The securing holes 416 may include conventional holes, locking holes, or slots.", "The holes may be threaded, unthreaded, or partially threaded, and may be fixed or polyaxial.", "In some embodiments, securing holes 416 may include variable low-profile holes that allow for locking at a variety of angles.", "The attachment portion 414 of the mounting member 410 may extend generally perpendicularly from another portion 415 of the mounting member 410, and may comprise one or more concave curved surfaces 417 configured to abut an outer portion 422 of an acetabular shell 420, or one or more convex surfaces (not shown) configured to abut an inner portion of a prepared acetabulum.", "Referring now to FIGS.", "96-102, certain embodiments provide components having porous beaded coatings and methods for their manufacture.", "Because implants and natural bone usually have different degrees of flexibility, uneven stress distributions may occur.", "Consequently, when an implant is loaded, there is generally some relative movement at the interface between the bone (more compliant) and the implant (more rigid).", "Many implants thus employ an intermediate material such as bone cement to reduce the amount of relative movement; however, cementless implants may rely on relative roughness to achieve the same goals.", "Historically, small spherical beads, bundles of thin wires, and thermal-sprayed metal have been used to produce the friction necessary to reduce the amount of relative movement.", "Optionally, screws and/or press-fit features may improve the fixation of implant to bone.", "Such technologies are generally accepted by the orthopedic surgeon community.", "However, the geometric nature of these coatings limits the location and size of their porosity.", "Newer technologies, such as those that employ asymmetric beads or metallic foams have improved the location and size of porosity, but they are difficult to manufacture with favorable surface textures.", "Remedies have included placing hatch lines into the surface of an already porous coating (e.g., via machining) Other porous surfaces have been manufactured having sharp protrusions at a microscopic level.", "These protrusions can cause problems when there is even a small amount of relative movement between the bone and implant.", "The sharper protrusions can dig into the bone and create bone particles or can break off from the implant and create wear particles at the implant-bone interface.", "In addition to loosening the attachment between the implant and bone, these loose particles can cause harmful complications.", "The shortcomings of previous porous surfaces are addressed by providing an implant having a surface that is textured with numerous blunt protrusions on a macroscopic level and has a porous structure on a microscopic level.", "The blunt protrusions create friction that reduces the amount of relative movement between an implanted component and surrounding bone.", "The porosity allows the surrounding bone to grow into the implant, and the lack of relative movement between implant and bone facilitates this ingrowth.", "A consideration in designing and creating a porous implant having blunt protrusions is the size and density of the protrusions.", "The protrusions create an area on which the bone initially contacts an implant.", "If the protrusions are too large or spaced too far apart, the majority of the implant's surface area between the protrusions will be too far from the bone for the bone to grow into the implant, and the bone may be unable to create a solid interface with the implant.", "In contrast, if the protrusions are too small or located too close together, their effect will be minimal and an implant may encounter the same problems as prior implants with smoother surfaces or surfaces composed of many concentrated sharp protrusions.", "An ideal surface contains protrusions that are large enough to create the needed friction between the bone and implant and still small enough to still allow for a high degree of bone ingrowth into the porous surface.", "The protrusions may be any suitable height, and preferably are between about 50 μm and about 2000 μm.", "For certain applications, it may be preferable to limit the protrusion heights to between 200 μm and 400 μm to achieve the desired level of friction and ingrowth with surrounding bone.", "Protrusions on a surface of an implantable component may be any suitable shape or profile desired for a general or specific application of the component.", "In certain embodiments, each surface protrusion may be a bump shaped as a portion of a sphere above the surface of the implant.", "Protrusions may also be shaped like wires or any other suitable features, including features common to cementless implants.", "FIGS.", "96 and 97 show some embodiments of an improved acetabular implant 1500 which may be a whole augment, a portion of an augment, a flange, a plate, other mounting member, a shell, or a cage.", "The improved acetabular implant 1500 mimics the bumpy outer surface geometries and profiles of clinically-successful porous beads, with the roughness and porosity of a desired ingrowth interface.", "The surface of implant 1500 is textured by blunt protrusions 1502, which are shaped substantially as hemispherical bumps on the surface of implant 1500.The protrusions 1502 are sized and spaced to create desirable friction that reduces movement of the implant 1500 relative to surrounding bone while allowing the surrounding bone to grow substantially into the porous protrusions 1502 and porous surface area 1504 between the protrusions.", "In addition to the protrusion heights discussed above, the spacing and density of protrusions 1502 affect the amount of friction and bone ingrowth created.", "Any suitable density of protrusions 1502 may be used for an implant, and the protrusions preferably occupy between about 10% and about 60% of the surface.", "The protrusions may be concentrated to a density of between about 0.25 beads/mm2 and about 6 beads/mm2.Improved acetabular implants, such as the implant 1500 of FIGS.", "96 and 97, may be formed by any suitable approach, and may be formed using one of the following four methods.", "A first method includes the steps of: 1) providing a mold having a negative impression of a porous beaded surface, 2) providing an implant substrate, which may be solid or porous, to be coated, 3) interposing small asymmetric particles between the implant substrate and said mold, and 4) applying a pressure and/or an elevated temperature to the mold, implant substrate, and small asymmetric particles to create a “green-state” implant (i.e., ready for full sintering) or a final implant (sintered), the implant having a roughened porous coating with an outer surface geometries and profiles mimicking a clinically-proven porous beaded structure with the roughness and porosity of a desired trabecular structure.", "A second method includes the steps of: 1) creating a 3D model simulating an outer surface profile of a porous beaded implant, 2) creating a model of an implant substrate volume, 3) applying the 3D model simulating an outer surface profile of a porous beaded implant to the 3D model of the implant substrate volume to create a bumpy pre-form volume, 4) applying an algorithm to fill the bumpy pre-form volume with a desired interconnected porous or otherwise reticulated structure to create a porous implant model, and 5) creating an implant having a roughened porous texture with an outer surface profile geometry mimicking a clinically-proven porous beaded structure using the implant model in a rapid-manufacturing process.", "A third method includes the steps of: 1) providing a mold of an implant having an inner surface mimicking a negative image of an outer surface profile geometry of a porous beaded surface, 2) providing a plurality of small asymmetric particles, 3) placing the plurality of small asymmetric particles into the mold, and 4) applying a pressure and/or an elevated temperature to the mold and/or small asymmetric particles to create a “green-state” implant (i.e., ready for full sintering) or a final implant (sintered), the implant having a roughened porous texture with an outer surface profile geometry mimicking a clinically-proven porous beaded structure.", "A fourth method includes the creation of a beaded surface on a foam component during the precursor step of making a metallic foam, the method comprising the steps of: 1) providing a mold of an implant having an inner surface mimicking a negative image of an outer surface profile geometry of a porous beaded surface, 2) loading one or more foaming agents into the mold, 3) creating a porous foam component (e.g., polymeric, polyurethane) in the general shape and/or size of said implant, which has an outer surface geometry mimicking an outer surface profile geometry of a porous beaded surface, 4) removing the porous foam component from the mold, 5) applying a binder or binding agent to the porous foam component, 6) applying a plurality of small symmetric or asymmetric particles (or a combination thereof) to the porous foam component having a binder or binding agent thereon, 7) subjecting the porous foam component having binder or binding agent and particles thereon to an elevated temperature to sinter the particles together and/or burn out the foam component to form a “green-state” implant (i.e., ready for full sintering) or a final implant (sintered), the implant having a roughened porous texture with an outer surface profile geometry mimicking a clinically-proven porous beaded structure.", "Implant has a bumpy outer surface profile and geometries mimicking a clinically-proven porous-beaded structure.", "The substrate forming at least an outer portion of the implant may be a bulk porous, reticulated structure resembling a trabecular structure.", "One or more core portions or outer surface portions of the implant may be solid (e.g., a portion of the implant may be configured for articulation with another implant component).", "The implant may also include one or more solid internal portions.", "For example, implant 1500 shown in FIG.", "96 may include a solid structural portion on the interior of the implant.", "The structural portion may be a single solid area or multiple solid areas on the interior of implant 1500 that provide a series of structural ribs to add support to the implant.", "The solid internal structure may have any suitable shape and configuration, such as a structural lattice similar to rebar in concrete.", "Illustrative but non-limiting examples areas where the internal structure may be desired include areas around screw holes, the equator region of an augment, or any other suitable area.", "In some embodiments, a polymer foam could be melted or burned to have the shape of beads—or the foam could be polymerized on a bead-shaped subsurface resulting in the end-product having a bead-shaped surface.", "In addition to solid internal components, implant 1500 may be coupled with external flanges or other mounting members to provide additional support to the implant.", "For example, implant 1500 may be implanted along with a flange that is attached to the implant at a first end of the flange and attached to a patient's bone at a second end, for example, with a bone screw secured into a through-hole in the flange.", "Implant 1500 may also include external solid reinforcements, similar to common strut and brace structures, to provide support to porous sections of the implant.", "For rapid-manufacturing technologies, the bead surface geometries and profile could be created virtually and subtracted out from a bulk porous entity or virtual beads could be created and combined with a porous entity.", "It is the general intent, in some, but not necessarily all, embodiments that the end-product be homogenous.", "Alternate embodiments of implants may include surface profiles that mimic metallic wire bundles or the peaks and valleys of a thermal sprayed coating.", "Once a virtual model of the desired geometry is created using modeling software, an implant component having the desired surface profile can be created using any suitable rapid manufacturing techniques.", "For example, the porous implant can be created using 3D printing technology that uses powdered metal to “print” the modeled implant.", "In such an approach, a foam may be created having a surface profile that includes protrusions, such as protrusions 1502 in FIGS.", "96 and 97, and the profiled foam may then be filled in with powdered metal to create a porous microstructure with the profiled surface.", "A foam that does not contain the protrusions may also be used to create the porous microstructure with powdered metal, and the desired surface profile with protrusions can then be stamped into the surface of the porous metal implant.", "Advantages of implants manufactured this way are that they contain integral porosity with the initially bone-engaging surface profile of clinically-proven porous beads.", "In other words, the same features providing the traction needed between bone and implant are the same features providing a surface for bone to grow into and around for a rigid and enduring fixation surface.", "As non-limiting examples, Tables A and B show some examples of potentially suitable bead density (spacing), and diameter.", "TABLE A Chart of number of beads in selected area and average and standard deviation of bead diameter of 50 beads on a shell used with the Birmingham Hip ® Resurfacing system available from Smith & Nephew, Inc. in at least 3 fields of view (SEM, Jeol, Japan) Beads in 6.4 × 4.8 mm area Bead Diamter (mm) 11 Average D 1.24 20 Std D 0.12 20 TABLE B Percent solid for typical beaded product for bone ingrowth.", "Product Company Implant Type Percent Solid CoCr ROUGHCOAT Smith and Profix ® Femoral 46.3% (2-layer) Nephew CoCr Porocoat DePuy LCS ® Knee 46.5% (3-layer) Femoral CoCr Porocoat DePuy AML ® Stem 50.2% (3-layer) Ti ROUGHCOAT Smith and Synergy ™ Stem 51.9% (2-layer) Nephew Wherein, “percent solid” is a 2D measurement of bead density produced by typical metallographic techniques based on the test method disclosed in ASTM F1854, entitled “Standard Test Method for Stereological Evaluation of Porous Coatings on Medical Implants,” which is incorporated by reference herein in its entirety.", "FIG.", "98 shows a coating volume 1510 having spherical bead volumes 1512 placed therein, such that the spherical bead volumes 1512 protrude from the coating volume 1510 to form a second coating volume mimicking a spherical bead profile.", "Alternatively, solid spherical beads may be combined into a porous coating.", "To create the coating volume 1510, two software models can be created and then merged to form the final model of the porous volume with the profiled protrusion surface.", "A first model of a macroscopic structure of the volume, including the plurality of bead volumes 1512, can be created in modeling software, and may look substantially the same as the volume shown in FIG.", "98.A second software model can be created to produce the porous microscopic structure desired for a macroscopic volume, such as the volume shown in FIG.", "98.FIG.", "99 shows a unit cell 1520 of an exemplary porous reticulated structure, which may configured to fill the coating volume mimicking a spherical bead profile.", "The unit cell 1520 is made up of a complex structure of struts 1512.The arrangement of struts 1512 creates voids 1514 within unit cell 1520, thus making the desired porous microstructure.", "The size and arrangement of struts 1512 can be varied to control the number and size of voids 1514.By controlling the size and arrangement of the struts 1512, a desired amount and profile of the porous structure is achieved.", "FIG.", "100 shows a cross section of a coating volume 1530, which may correspond to coating volume 1510 of FIG.", "98, mimicking a spherical bead profile after the volume has been replaced with a reticulated structure (e.g., via a repeating unit cell such as unit cell 1520 in FIG.", "99 in CAS software, or using any of the 4 methods described above).", "The finished coating volume 1530 exhibits both the profiled macrostructure and porous microstructure.", "The dotted lines in FIG.", "100 outline the surface profile of coating volume 1530 and shows the protrusions that create a bumpy surface that produces friction with bone when implanted.", "The microstructure of coating volume 1530, made up of a combination of solid structure 1532 and voids 1534, creates a porous implant into which surrounding bone can grow to fill in voids 1534 and create a solid mating of implant and bone.", "FIG.", "101 shows an SEM image 1540 taken at 25× magnification of the surface of a part made by the disclosed method.", "Surface topography is not apparent with this view.", "FIG.", "102 is an SEM image taken 1550 at 50× magnification of the structure made with the disclosed method.", "The structures shown in FIGS.", "101 and 102 exhibit the porous microstructure discussed above with respect to coating volumes 1510 and 1530, and can be created by merging a solid macrostructure with a porous microstructure model, such as the unit cell 1520 in FIG.", "99.As a further non-limiting example, the following chart shows some additional exemplary parameters that have proven to be useful for various embodiments.", "In the chart below, MVIL refers to Mean Void Intercept Length, which is another way of characterizing the average pore size, particularly in structures where the pore shapes and sizes are not uniform.", "On generally known definition of MVIL is “measurement grid lines are oriented parallel to the substrate interface.", "The number of times the lines intercept voids is used with the volume percent void to calculate the mean void intercept length.” Electron beam Direct metal laser Landon melting sintering (SLS) Structure (EBM) Eurocoating EOS (FIG.", "99) Avg.", "Strut Thickness (μm) — 275-450 275-400 (360) (340) Avg.", "Pore Size: MVIL 300-920 * 450-690 — (565) (560) Average Pore Pore 900-1300 * 1310 ± 280 1970 ± 40 Size: (μm) Window — 370 ± 100 830 ± 150 Not 670-1340 600 ± 100 — Specified * (fine, medium, and coarse structures) It is generally desirable to provide between about 60-85% porosity.", "Pore sizes may generally range between about 50-1000 microns.", "In the above example, the smallest pore size provided was about 300 microns, and the smallest window was about 595 microns across at its largest diameter.", "It will be understood that this example is intended to be non-limiting and provided for illustrative purposes only.", "The systems, methods, and devices described herein to create implants having both a profiled macrostructure and a porous microstructure can allow a medical professional to utilize customizable, patient-specific implants.", "A customized implant can be efficiently created using the rapid manufacturing techniques discussed herein by merging two or more models of an implant and then printing the modeled component.", "This could allow a medical professional, such as an orthopedic surgeon, to order an implant specific to a single patient, including modeling the size and shape of the implant to fit defects or other unique features of the patient's anatomy.", "This process can also be automated by taking bone scans of the patient's anatomy or using other available medical imaging and modeling techniques to automatically create a 3D model to use for rapid manufacturing.", "The ability to customize an individual implant also allows a medical professional to adjust the detailed macrostructure and microstructure of the implant to fit the needs of a particular application.", "For example, an orthopedic surgeon can adjust the macrostructure of the implant by selecting the shape, height, density, or other characteristics of protrusions on the surface of the implant.", "The surgeon can also customize the number and size of voids within the implant to achieve a desired porosity for the implant.", "In some embodiments, the surgeon may also select the configuration of the macrostructure of the implant.", "For implants that include internal solid portions for strength and structure, the surgeon can customize the size and location of the internal solid portions to provide the structure in certain non-uniform areas of the implant where increased strength is needed.", "Illustrative but non-limiting examples areas where increased strength may be desired include areas around screw holes, the equator region of an augment, connection sites of augments, augment areas that are thinner than others, or any other suitable area.", "The surface profile of the implant can also be non-uniform if different areas of the implant require different levels of friction or surface area for a bone interface.", "A surgeon may want a higher concentration of surface protrusions in certain areas of the implant, such as areas that experience higher levels of stress, and a lower concentration of protrusions, or no protrusions at all, in other areas.", "Porous implants described herein allow for an implant to provide good contact surface area and friction regardless of the quality of bone into which an implant is implanted.", "For example, patients who have soft spongy bone may need features that are longer, and a lower number of those features.", "Patients with hard dense bone may require features that are shorter, but a higher number of those features to create the same fixation in the bone.", "The specific requirements of a patient's anatomy and bone quality can be accommodated by the individualized design options provided by the porous implants described herein.", "Referring now to FIGS.", "103-115, there are some instances during hip arthroplasty when an expandable augment or expandable shell implant may be desired.", "Initial fixation during hip arthroplasty is important, but the shapes of conventional augments may not be ideal and conventional bone preparation for receiving shaped augments and shells may not be precise.", "For example, hand-reaming is typically used to prepare an affected area of bone and create a shaped void for receiving an augment or shell.", "Although surgeons try not to remove more bone than necessary, in some instances, the surgeon may unintentionally create a slightly larger opening or an oblong void that does not precisely fit the shape of outer surfaces of an augment or shell to be implanted.", "Moreover, poor bone quality may affect the press fit and/or total interference between bone and an augment or shell even if the bone is well-shaped to fit external geometries of the augment or shell.", "Cement, allograft, and bone pastes have been used in the past to fill in the gaps between augments, bone, and implants.", "However, FIGS.", "103-115 show several embodiments of augments, shells, and/or mounting members that may be expanded to compensate for poor bone quality or non-precise bone preparation (e.g., over-reaming).", "The augments, shells, and/or mounting members are preferably manufactured by a rapid manufacturing method (e.g., stereolithography, 3D-printing, selective laser sintering (SLS), electron beam welding (EBM), etc.).", "The augments, shells, and/or mounting members may also be machined or casted from a bulk material and then plasma-sprayed or otherwise coated with a surface texture or porous ingrowth structure.", "They may have a generally porous outside for contact with bone, and may have one or more non-porous external or internal surfaces and volumes for attaching to implants or improving strength and flexibility of the augments, shells, and/or mounting members.", "The expandable augments, mounting members, or other implants, including shells and cages, have at least first and second portions that are connected, for example, by a soft or adjustable hinge portion or by a wire fixation or other suitable means, and the connections allow for separation of the portions.", "The separation is controlled by actuating an expansion member disposed between the at least two portions.", "As shown in FIGS.", "103-107, an expansion member 1602, non-limiting examples of which may include a wedge, fastener, mandrel, screw, or other component, is inserted into an augment in order to expand the augment once it is placed inside or adjacent to a prepared bone cavity.", "The expansion member 1602 is actuatable, for example, by a surgical tightening rod or driver.", "A torque wrench can be utilized to ensure that the augment, shell, or mounting member has a proper interference or “press-fit” with surrounding bone, without fracturing the bone.", "Alternatively, as shown in the expansion member 1630 in FIG.", "108, an expansion member itself may comprise torque-limiting means such as a frangible driver portion 1632 with a calibrated circumferential notch or groove 1634 that is designed to shear off after a specified torque is reached.", "By controlling the amount of torque applied to an expansion member, a proper press fit and interference with surrounding bone is achieved.", "As shown in augments 1600, 1610, and 1620 in FIGS.", "103-107, the outer geometries, shape, or size of an augment may be initially biased inwardly or undersized, and then expanded with an expansion member, which may alternatively comprise or be provided by a shape memory polymer or wedging action from a setscrew.", "For example, two portions 1604 and 1606 of augment 1600 in FIG.", "103 are initially biased toward each other but are displaced away from each other upon actuation of the expansion member 1602.An augment, shell, or mounting member may have one or more flexible hinge portions, such as hinge area 1608 of augment 1600 to create a fulcrum for two or more other augment, shell, or mounting member portions to move in relation with each other.", "The geometrics or portions of the augment, shell, or mounting member may also or alternatively be connected by a wire, screw, staple, threaded expansion rod or other structure, which holds the portions together but still allows them to expand under actuation of the expansion member.", "Additionally or alternatively, the augment or mounting member may have one or more slit portions, such as slit 1609 of augment 1600, to allow for even radial expansion.", "In certain embodiments, there may be a slit portion, a cruciform, or any other appropriately shaped cut or division in the augment, shell, or mounting member positioned a set desired distance or a set angle from one another so that the augment, shell, or mounting member portions expand evenly when one or more expansion members are positioned.", "In FIGS.", "104 and 105, an augment is provided that has two augment portions 1612 and 1614 separated by a slit 1616 and hinged together by a flexible hinge portion 1618.It will be understood that additional or fewer augment portions may be provided, and that the portions may also be provided on one or more mounting members and that the following description would be related thereto.", "The flexible hinge portion 1618 allows the augment portions 1612 and 1614 to move away from each other upon insertion of an expansion member 1602, which is shown as an expansion screw, but may be any other type of expansion member, such as a wedge, a plug, a bone screw, a set screw, a member having a smooth bore with a taper, a shape memory plug, or any other component, which, in turn, expands the entire augment.", "While not shown, one or more additional slits and/or flexible hinge portions may be added to allow a more uniform radial expansion.", "The augment 1610 shown in FIGS.", "104 and 105 may include one or more porous portions to facilitate bone ingrowth into the augment.", "For example, each of augment portions 1612 and 1614 may be porous.", "All of augment 1610 may be porous for bone ingrowth, or some portions of augment 1610 may be porous and some may be solid to provide strength to augment 1610.It may be desirable to provide a solid core in augment 1610 surrounded by porous outer portions to provide needed strength at the interface between augment 1610 and expansion member 1602 while still providing porous portions 1612 and 1614 for bone in growth.", "For example, the inner core of augment 1610 outlined by the dotted line in FIGS.", "104 and 105 may be solid to provide needed strength around expansion member 1602 while augment portions 1612 and 1614 may be porous for ingrowth.", "FIGS.", "106 and 107 show an expandable augment 1620 that may be implanted and expanded similar to augments 1600 and 1610 discussed above in FIGS.", "103-105.In particular, Augment 1620 includes two portions 1622 and 1624 that move radially outward when expansion member 1602 is inserted into augment 1620.Augment 1620 may be made of a solid material with surface treatment, a porous material, or may be a combination of solid and porous sections to provide both strength and bone ingrowth for the augment.", "The dotted line in FIGS.", "106 and 107 may separate a solid core of augment 1620 that surrounds the threaded hole for expansion member 1602 from a porous peripheral portion of the augment, as discussed above with respect to FIGS.", "104 and 105.The solid and porous portions may be located and separated within the augment in any suitable geometry, as shown in the different solid and porous geometries in augment 1610 of FIGS.", "104 and 105 and augment 1620 of FIGS.", "106 and 107.During replacement or revision surgery, a surgeon may use any of the augments shown in FIGS.", "103-107 to fill bone voids surrounding an implant.", "Depending on the anatomy of a certain patient and the surgical procedure, the augment may be placed into a bone void either before or after an implant shell is inserted.", "The augment may also be attached to the shell before implantation, before expansion begins, or after the augment is expanded to its final size.", "The surgeon positions the augment within the bone void in a contracted state such that there is space in the bone void that is not initially filled by the augment.", "The surgeon then activates an expanding component of the augment, for example, by turning a set screw with a surgical tool, to cause two or more portions of the augment to expand.", "The surgeon expands the augment until the augment fills substantially the entire bone void and abuts both the implanted shell and the patient's bone.", "The augment is then fixed in place, either by mechanical fasteners such as screws or by allowing surrounding bone to grow into ingrowth surfaces on the augment.", "Because the augments, shells or mounting members shown and disclosed in FIGS.", "103-115 are slowly expanded in-situ within the prepared bone void, impaction forces are avoided, but bone interference and press-fit is still achieved.", "Moreover, the risks of bone fracture, sitting too proud from a bone surface, and too much bone interference/press-fit (all generally being associated with impaction techniques) are mitigated or eliminated.", "It should be noted that one advantage of the devices shown in FIGS.", "103-115 is that augments, shells, or mounting members may be more easily removed during revision surgeries due to the slits and flexible hinge portions provided thereon.", "For example, in a revision hip surgery, a surgeon may first remove the expansion member and then simply impact the augment, shell, or mounting member radially-inwardly from a side portion to fold the augment or mounting member, urging the augment or mounting member portions towards each other and away from outer areas of bone ingrowth.", "In another example, the one or more slits generally “compartmentalize” the augment, shell, or mounting member into several smaller outer ingrowth surface areas.", "Therefore, each augment, shell, or mounting member portion may be removed individually from well-fixed bone with greater ease than for a well-fixed non-adjustable/expandable implant that may have an entire outer solid surface that is well-fixed with bone ingrowth.", "Lastly, slits may facilitate the entry of a saw blade, osteotome, or other cutting tool (e.g., a Midas Rex® pneumatic tool by Medtronic) for removing the augment, shell, or mounting member from well-fixed bone.", "The threaded openings provided in the augment, shell, or mounting member may be engaged by a threaded distal end of a slap hammer tool for removal from well-fixed bone in a manner similar to that used for hip stem removal during revision total hip arthroplasty (THA).", "FIG.", "109 shows an expandable/adjustable augment 1640 related to the embodiments described above and shown in FIGS.", "103-108.The augment 1640 may have any outer peripheral shape to accommodate various bone voids and defects.", "While the entire augment 1640 may be solid and simply surface textured to improve bone ingrowth properties, volume portions of the expandable/adjustable augment 1640 may be fully porous.", "In FIG.", "109, the augment 1640 comprises at least two fully-porous volume portions 1642 and 1644 separated by a solid portion 1646.The fully-porous volume portions 1642 and 1644 are movable with respect to each other.", "The solid portion 1646 may extend all the way to an outer periphery of the augment 1640 proximate a hinge region 1648 as shown in order to better distribute stresses and maintain the integrity of the struts and nodes of the ingrowth structures contained within the fully-porous volume portions 1642 and 1644.This design may help reduce cracks and fatigue failure.", "As shown in dotted lines in FIG.", "109, the expandable/adjustable augments disclosed herein may comprise additional intersecting slits to separate portions of the augment into multiple portions, such as thirds, quarters, or any other appropriate division.", "An expansion member 1650, which may be any of the above-described expansion members such as a screw, wedge, or plug, may be inserted into the augment 1640 to expand the augment 1640 in at least one direction, such as in a radial direction or a width.", "A receiving portion 1652 may be provided on the expandable/adjustable augment 1640 which receives the expansion member 1650, and is generally complementary to the shape of the expansion member 1650.For example while it may not be shown, either the expansion member 1650 or the receiving portion 1652 may be tapered, undersized, oversized, threaded, shim or wedge-shaped, threaded, smooth, symmetrical, non-symmetrical, conical, cylindrical, concentric, eccentric, and may be provided with various cross-sectional geometries, non-limiting examples of which are shown in FIGS.", "110 and 111.In some non-limiting examples, the expansion member 1650 may comprise a screw, a quarter-turn fastener, a shape-memory plug, a wedge, or a settable or injectable material such as an injectable polyurethane, or packed graft material.", "FIGS.", "110 and 111 show non-limiting examples of a wedge expansion member for use with expandable/adjustable augments and mounting members disclosed herein.", "FIG.", "110 shows a locking wedge 1690, and FIG.", "111 shows a locking pin 1692 with a removal head 1694, which, when inserted into a recess of an expandable/adjustable augment or mounting member, may keep the augment or mounting member in a desired expanded state.", "The wedge expansion member shown in either FIG.", "110 or 111 may be inserted at different depths within the expandable/adjustable augment to expand or contract the expandable/adjustable augment or flange to different diameters or peripheral shapes.", "FIG.", "112 shows an expandable/adjustable augment 1660 that is similar to the ones shown in FIGS.", "103-109, incorporating a tapered plug expansion member 1662.The tapered plug expansion member 1662 may have an inclined or otherwise tapered outer surface that wedges against a complementary inclined or otherwise tapered inner surface provided within the body of the expandable/adjustable augment 1660.FIG.", "113 shows an expandable augment 1670 similar to the one shown in FIG.", "112, wherein expansion of the augment 1670 is controlled by the turning of one or more positioning screws 1672.An upper plate member 1674 having an expansion member 1676 provided thereon is placed on top of an expandable augment portion.", "As the positioning screws 1672 are introduced and tightened, the upper plate member 1674 moves closer to the augment 1670, and the expansion member 1676 moves into a receiving portion 1678 located adjacent an expandable region in the augment 1670 to bulge the augment 1670 radially-outwardly.", "FIG.", "114 illustrates an expandable/adjustable augment 1680 similar to the ones shown in FIGS.", "103-113, wherein expansion of the augment 1680 is controlled by the turning of multiple expansion screws 1682.The augment 1680 may be configured to expand by different amounts in different regions of the augment 1680.A plurality of slots 1684 may split the augment 1680 into several portions that are moveable relative to each other.", "The expandable/adjustable augment 1680 may be used to secure a press fit around its entire perimeter even if a surgeon wobbles a reamer, or if the bone void is prepared with a slightly different shape and/or size than the undeformed expandable/adjustable augment 1680.FIG.", "115 shows an expandable/adjustable implant shell 1700 that provides an implant having an adjustable size to allow for precise fit to a reamed bone void, similar to the expandable and adjustable augments discussed with respect to FIGS.", "103-114.The shell 1700 has a threaded hole 1704 that receives an expansion member 1702.Expansion member 1702 may be a mandrel, screw, wedge, plug, or any other suitable expanding component.", "Depending on the expansion member used, threaded hole 1704 may be replaced by a non-threaded hole and may have any shape or contour needed to receive expansion member 1702 and cause the shell 1700 to expand.", "The shell 1700 has slits 1706 cut into shell 1700 to allow for flexibility needed to expand the shell.", "The slits 1706 create multiple segments 1708 around the shell that can be forced outward for expansion.", "Any number of slits 1706 and segments 1708 may be used to provide the desired amount of flexibility and expansion.", "As expansion member 1702 is placed into the shell 1700, for example, by a surgeon manually screwing expansion member 1702 into threaded hole 1704, the shell 1700 expands as segments 1708 are forced radially outwards, increasing the profile of the shell 1700 and allowing the shell 1700 to fill surrounding bone voids.", "Expandable and adjustable augments may also be used to facilitate removal of the augments in revision surgeries.", "Implant shells occasionally require revision surgery due to wear of the implant or changes in a patient's anatomy, and revision surgeries to improve the implants may involve removing augments as well as implanted shells.", "An expanding augment that is used to fill a patient's bone void can make the removal process easier by allowing a surgeon to reverse the expansion and return the augment to its contracted state for quick removal.", "A modified expandable augment that provides for convenient removal is shown in FIG.", "166.FIG.", "166 shows an augment 1240 that may be provided with recess portions 1242, which, in this embodiment, are shown alongside a split portion 1244, but which can be provided anywhere on the augment 1240, or even on augments not having a split portion.", "Recess portions 1242 are configured to receive a clamp or other instrument 1246.Recess portions 1242 may be curved or otherwise shaped to correspond to the instrument to be used.", "For removal of the augment 1240, arms 1248 of the instrument 1246 may be inserted into recess portions 1242 in order to securely grasp the augment 1240, squeeze the augment 1240, and pull the augment 1240 from bone.", "The mechanical advantage of the clamp 1246 causes the augment 1240 to squeeze or shut slightly or otherwise flex inwardly, particularly in split augment embodiments, so that the augment 1240 may be removed, even if well fixed in bone.", "The split augment 1240 shown may move from a first position, shown as the outer boundary 1250 in solid lines, to a second compressed position, shown in dotted lines 1252 in a direction shown by inward arrows 1254.This compression allows removal of the augment 1240 in a relatively easier and more efficient manner than chipping away at the augment 1240 or cutting the augment 1240 out in separate portions with a blade.", "Recess portions 1242 and instrument 1246 may also be used to initially position or introduce the augment 1240 into a bone void.", "Once positioned, an expansion member, such as any of the expansion members shown and described herein, may be used to expand and lock the augment 1240 into place.", "Although not shown, it may be desirable to insert plugs or any other appropriate recess portion cover to prevent bone ingrowth therein.", "Alternatively, bone graft material or injectable polymers or any other filler material may be inserted into recess portions, particularly if recess portions are to be used solely for insertion and are not envisioned for use in subsequent removal.", "FIGS.", "116 and 117 are a front perspective view and a back view, respectively, of an augment according to certain embodiments.", "In FIGS.", "116 and 117, augment 910 is in the shape of a staple and is provided with a number of projections and optional fixation elements.", "For example, augment 910 includes two projections 920 extending from a base portion or member 970, although it is possible that the augment 910 may have three or more projections that extend from a base member as described below.", "As shown, the projections 920 may be disposed in substantially the same direction from the augment 910 defined by the respective axis of each projection, with a gap 925 between the two projections 920.In certain embodiments the projections 920 may be angled or otherwise offset such that the projections 920 are not disposed in the same direction from the augment 910; however, there may still preferably be a gap disposed between the two projections 920.Furthermore, although the length of the projections 920 is shown as being substantially the same, it will be understood that the length of one of the projections 920 may be different than the respective length of the other projection.", "The base member 970, or the projections 920, or both, may have a surface that is substantially arcuate, for example, in order to complement an outer curved surface of an acetabular shell or other implant.", "Optional fixation elements include screw holes 930 and cement troughs 960.The fixation elements fix the augment 910 in place when implanted.", "Each fixation element may connect the augment 910 to a patient's bone, an acetabular shell, or both.", "The augment 910 may also include a connection element 940 on base member 970, for example, at the center top of the augment 910.In certain embodiments, connection element 940 is a threaded opening that may be attached to the end of a driver handle (e.g., driver handle 1060 of FIG.", "122) for assisting with the implantation of the augment 910.However, the connection element 940 may be a tapered connection, a quick-connect, or any other type of fitting.", "The augment 910 may further include timing marks 950 to allow the augment 910 to be properly placed within the hip bone.", "Installation of the augment 910 is described in further detail below.", "FIG.", "118 is a top view of an augment installed on an acetabular shell.", "Augment 860 may be similar to augment 910.As shown, augment 860 is positioned next to acetabular shell 862 such that timing marks 864 disposed on the augment 860 are aligned with timing marks 866 disposed on the acetabular shell 862.The base member of augment 860 has an arcuate surface that contacts the complementary curved outer surface of the acetabular shell 862.As described above, an augment such as augment 860 may be fixed to the acetabular shell 862, a patient's bone, or both, via optional fixation elements such as screw holes and cement troughs.", "FIGS.", "119-122 illustrate exemplary methods for installing an augment 910 into a patient's joint according to certain embodiments.", "FIG.", "119 is a cross-sectional elevation drawing of an acetabulum 990 and an acetabular shell 1010.The acetabulum 990 would have been prepared to receive the shell 1010 by reaming, rasping or the like.", "Bone screws 1020 or other appropriate fixation devices have also been installed to secure shell 1010.Also shown is bone deficient area 1000.This area 1000 is a void space extending from the outer wall of the acetabular shell 1010 to the acetabulum 990.In FIG.", "120, the acetabulum 990 is prepared for the augment 910 by use of broach 1030.The broach 1030 can be of any kind useful for rasping or reaming bone.", "For use with the augments described herein, the broach 1030 is typically provided with a depth stop 1040.Depth stop 1040 prevents the broach 1030 from removing too much bone by catching, for example, on the rim of acetabular shell 1010.The broach 1030 may have roughly the same cross-sectional profile and overall shape as the augment 910 and is typically sized to allow the augment 910 to be wedge-fitted into bone deficient area 1000.The broach 1030 may also have a slot provided therein to allow the broach 1030 to slide on either side of the installed screw 1020 to clear away bone on both sides of the screw 1020.In FIG.", "121, the acetabulum 990 has been prepared for the augment 910.Bone deficient area 1000 has been replaced with prepared space 1050 between the acetabulum 990 and the acetabular shell 1010, the prepared space including screw 1020.The next step in the procedure is illustrated in FIG.", "122.The augment 910 is attached to driver handle 1060 and inserted into prepared space 1050.During insertion, the surgeon matches the timing marks 950 on the top of the augment 910 to timing marks (e.g., timing marks 886) on the acetabular shell 1010 to ensure that bone screw 1020 is avoided.", "The augment 910 is inserted into the prepared space by positioning the augment around the screw 1020 (or any other fixation member) such that the screw 1020 extends through the gap 925 between projections 920 of augment 910.Once the augment 910 has been pushed into place by hand, it may be tapped into its final position with a hammer.", "If the surgeon desires, the surgeon may then fix the augment 910 even further by using augment screws placed into screw holes 930 and then into the patient's bone.", "Alternatively or additionally, the surgeon can pour bone cement down the troughs 960 illustrated in FIG.", "116.The cement may bind the augment 910 to the acetabular shell 1010, the patient's bone, or both.", "In some embodiments, the augment 910 is held in place solely by a friction fit.", "In some embodiments, fixation devices like bone screws or cement may be used to secure augment 910 in place, for example, via screw holes 930 or cement troughs 960, respectively.", "Any kind of bone screw or cement familiar to one of ordinary skill in the art may be used.", "FIG.", "123 shows a front perspective view of an augment having three projections extending from a top or base member according to certain embodiments.", "For example, augment 910′ may be similar to augment 910 of FIG.", "116, but augment 910′ includes three projections 920′ extending from the top member 970′.", "It will be understood that in certain embodiments an augment may include more than three projections.", "In some embodiments, the augments described above may be provided with flanges, blades, plates, hooks, any other suitable mounting members, or any combinations thereof.", "For example, FIG.", "124 shows a top plan view of an augment 1080 with flange 1090.Flange 1090 may provide additional support for the augment 1080 on the outside of the acetabulum (e.g., acetabulum 1092 of FIG.", "125).", "FIG.", "125 illustrates a partial cross-section elevation view of an augment 1080 installed in acetabulum 1092 with flange 1090 having bone screw 1094 provided therethrough.", "The augments described herein may be made of a number of materials, including Titanium, Cobalt-Chromium, Zirconium oxide, any other biocompatible materials or alloys that have the appropriate strength, resistance to wear, etc., or any combinations thereof.", "The augments may also be made fully porous or partially porous to allow for greater bone in-growth, for example, and the augments may be coated with hydroxyapatite or any other bone-promoting agents or combinations thereof.", "The embodiments described preferably above allow a surgeon to implant the acetabular shell or cup first and gain desired screw fixation and then prepare the bone minimally to fit a desired augment.", "This enables the surgeon to get the desired fixation for the acetabular shell without compromising the surgeon's ability to use an augment.", "An additional advantage is that the surgeon removes no more bone than is necessary.", "FIGS.", "126 and 127 illustrate an augment and flange combination 1100 for attachment to an acetabular cup (also referred to as an “acetabular shell,” “shell,” “cage,” or “cup”) or other partially-spherical augment.", "Combination 1100 includes augment 1102 and flange 1104 coupled to acetabular cup 1106.It will be understood that in place of, or in addition to, flange 1104, other mounting members may be used, including but not limited to various blades, hooks, plates, any other suitable mounting member, or any combinations thereof.", "In some embodiments, the augment and flange combination 1100 may be configured to provide up to approximately 45° of circumferential coverage around acetabular shell 1106.The augment and flange combination 1100 may be provided in multiple sizes to fit multiple cup sizes, for example, cup outer diameter sizes ranging between approximately 30 mm to approximately 90 mm.", "The augment and flange combination 1100 generally utilizes a modular plate member (e.g., flange 1104) which is configured to be fixed to the acetabulum.", "The flange 1104 may be bent, shaped, or otherwise contoured to the anatomy of the patient, and may be adapted to be cut or otherwise provided in various lengths to allow an end user to select from a long or short plate member.", "The augment and flange combination 1100 may be positioned in a superior position (as shown in the FIGS.", "126 and 127).", "In such instances, it is likely that a longer plate member may be used.", "The augment and flange combination 1100 may offer anterior coverage (as shown), or, while not shown, may be positioned inferiorly to provide posterior coverage.", "In the latter instance, a shorter plate member may be desirable.", "FIGS.", "128 and 129 show some embodiments of a posterior wall augment and mounting member combination 1110.Combination 1110 includes augment 1112 and mounting member 1114 coupled to one another and to acetabular shell 1116.A kit of posterior wall augments and mounting members may be provided in multiple sizes, shapes, and lengths to accommodate different patients and to fit multiple cup sizes, wherein the cup may be an acetabular shell, cage, or other augment.", "The multiple cup sizes may be, for example, cups having outer diameters ranging from approximately 30 mm to approximately 90 mm.", "In some embodiments, the posterior wall mounting members or augments may be configured to provide approximately 45° of circumferential coverage circumferentially about an acetabular shell, cage, or other augment.", "In some instances, the mounting member or augment may be universally used on either right and left hips.", "FIGS.", "130 and 131 illustrate some embodiments where an acetabular shell or cage 1120 (or, in some embodiments, an augment) has a concentric frustoconical tapered inner surface 1122 configured to taper lock with a complementary frustoconical tapered outer surface of a band 1124.The band 1124 is pressed onto or otherwise provided on a separate liner 1126 adjacent a rim portion of the liner 1126.The liner 1126 may be metallic, polymeric, or ceramic.", "The liner 1126 has a central axis 1128 which is angled with respect to the axis 1130 of both the acetabular shell/cage 1120 and the frustoconical tapered outer surface of the band 1124 (e.g., the liner axis 1128 is not parallel or co-linear with the shell/cage axis 1130).", "The liner and band assembly 1132 may be placed at any angular orientation with respect to the acetabular shell/cage 1120 before engaging the tapered outer surface of the band 1124 with the frustoconical tapered inner surface 1122 of the shell/cage 1120.By allowing some degree of angularity between the liner axis 1128 and the axis 1130 of the shell/cage 1120, a surgeon can independently compensate for inadequate “cup angle” after the shell/cage 1120 is already secured to bone for best coverage, void fill, and fixation.", "In other words, the devices shown in FIGS.", "130 and 131 allow a surgeon to decouple two surgical steps, without making a compromise between optimal fit/coverage, and liner angle/joint stability/range-of-motion.", "With hard-on-hard bearings, fluid film lubrication is important to preserving the wear benefits of the bearing couple.", "Any deformation of the acetabular shell 1120 and liner 1126 due to the geometry of the patient's pelvic bones may cause the effective clearance to be reduced, which can disrupt fluid film lubrication.", "Alternatively, the band 1124 may be “integrally-provided” with the liner 1126 as a single unitary machined piece instead of pressed on as a separate member.", "In some embodiments, the frustoconical tapered outer surface provided to the liner 1126 may not be orthogonal to the equatorial face or rim surface of the liner 1126 (e.g., a “lipped liner” may be provided, wherein the lip is skewed with respect to the taper lock).", "In some alternative embodiments, the mating tapered surfaces may allow insertion of the liner 1126 in either a coaxially-aligned relationship with respect to the shell/cage 1120 (or, in some embodiments, an augment), or in a non-coaxially-aligned relationship.", "Changing the amount of mating taper surface area between the frustoconically-tapered outer surface and the frustoconically-tapered inner surface at different circumferential locations around a periphery of the connection may actually cause a non-uniform taper lock.", "In other words, the frustoconically-tapered outer surface may only contact the frustoconically-tapered inner surface band at a few discrete points, and may help reduce deformation of the liner by counteracting rim impingement forces on the shell/cage/augment from surrounding acetabular bone.", "FIGS.", "132-134 show a deep profile acetabular augment 1136 according to some embodiments, which fills in deep defects without offsetting the center of the joint.", "In other words, the deep profile acetabular augment 1136 can convert an existing standard cup implant to a cup implant having an increased offset.", "The deep profile acetabular augment 1136 is configured to attach to an acetabular shell, cage, or other augment via a fastener such as a bolt or screw.", "As shown in FIG.", "134, for example, deep profile acetabular augment 1136 is attached to an acetabular shell 1138.In the particular embodiment shown, the fastener is a screw 1140 which is inserted through a screw hole located in the acetabular shell 1138 (e.g., an R3™ acetabular shell by Smith & Nephew, Inc.), adjacent to the apex of the shell 1138.The screw 1140 passes through the shell 1138 and connects the acetabular shell 1138 to the deep profile augment 1136.The deep profile augment 1136 may come in multiple depths/thicknesses/offsets.", "For example, the augment 1136 may increase the depth of an acetabular shell, cage, or other augment by approximately 1 mm to about 20 mm without limitation.", "The deep profile acetabular augment 1136 shown in the figures represents a +8 mm depth.", "Internal geometries (e.g., internal diameter or radius) of the deep profile acetabular augment 1136 may range to accommodate the outer geometries (e.g., outer diameter or radius) of multiple acetabular shell sizes.", "For instance, a kit of deep profile acetabular augments may be provided, the kit comprising a set of deep profile acetabular augments for each acetabular shell size, each set of deep profile acetabular augments comprising multiple depths, thicknesses, or offsets.", "Such deep profile acetabular augments may be particularly advantageous for use with protrusion acetabulums or acetabulums having Paprosky type IIC acetabular defects.", "FIGS.", "135-140 show a superolateral augment or flange member.", "As shown, the superolateral augment/flange member 1142 may be fully symmetrical, thus allowing it to be universally used in both left and right hips.", "The superolateral augment/flange member 1142 may come in multiple depths, for instance, approximately 0.01 mm to approximately 40 mm (shown in FIGS.", "135-140 as a +20 mm depth) and multiple sizes to fit multiple cup sizes, for instance, cup outer diameters ranging between approximately 30 mm and 90 mm.", "The augment/flange member 1142 may be provided with one or more widened or tapered holes 1144 that do not restrict screw angulation or placement.", "In this manner, polyaxial screws may be used, and the surgeon may insert the screws into a patient's bone at a desired angulation to obtain bone purchase in select areas.", "The augment/flange member 1142 may be of particular use for acetabulums with Paprosky type IIIA acetabular defects.", "The superolateral augment/flange member 1142 may be configured to allow screws such as screw 1146 to pass from the inside of a 3-hole or multi-hole cup 1148 through a cup wall, and subsequently through a wall of the superolateral augment/flange member 1142 to engage the acetabulum and surrounding bone, while maintaining or enabling full screw angulation.", "Alternatively, the superolateral augment/flange member 1142 may be configured to be initially directly attached to acetabular bone by one or more screws.", "In this instance, a no-hole cup may then be cemented over the augment/flange member 1142 (in-situ) at an inner surface of the augment/flange member 1142 that faces away from bone.", "Such embodiments configured for use with a no-hole cup may be desirable, because no-hole cups provide an uninterrupted barrier between the liner and cup and help prevent articulation wear debris from reaching the backside of the liner (i.e., between the cup and liner).", "In either of the embodiments described above, benefits are realized when compared to prior designs.", "For example, some currently-available designs need to be cemented and do not allow screws originating from the inner cup diameter to engage the augment before engaging the acetabulum.", "Moreover, other currently-available augments do not allow for full screw angulation.", "FIGS.", "141-159 show an acetabular mounting member or augment comprising a polyaxial screw hole.", "As shown, the mounting member or augment 1150 may comprise a solid substrate 1152 adjacent an aperture 1154 having an engagement structure 1156, which may be machined, for complementarily engaging a polyaxial screw head 1158.The polyaxial screw head 1158 may be rounded or threaded, and the engagement structure 1156 may comprise smooth rounded surfaces, threads, partial threads, tabs, or deformable structures that are complementary to the polyaxial screw.", "Various examples of polyaxial locking systems and methods are shown and described in U.S. Patent Application Publication No.", "2002/0147499, entitled “Locking Systems for Implants,” U.S. Patent Application Publication No.", "2008/0300637, entitled “Systems and Methods for Using Polyaxial Plates,” and U.S.", "Provisional Patent Application No.", "61/178,633, entitled “Polyaxial Fastener Systems and Methods,” all of which are intended for potential use in connection with the systems described herein and are incorporated by reference herein in their entireties.", "Any of the screws or fixation members used in connection with any of the embodiments described herein may be locking screws, polyaxial screws, or screws that are generic in nature.", "They may have a threaded head as shown in FIGS.", "141, 143, and 147, or may, alternatively, comprise a rounded, tapered, or spherical head 1160 that mates and forms a locking connection with a tapered recess or aperture 1162 as shown in FIG.", "149.In some embodiments, polyaxial screws may be utilized.", "FIGS.", "144-148 show some non-limiting examples of screws 1164-1168 that may be used with the augments and/or mounting members described herein, including but not limited to 2.7 mm cortex screws, 5.0 mm partially-threaded osteopenia screws, 5.0 mm osteopenia screws, fully-threaded 3.5 mm locking screws, and 3.5 mm cortex screws, respectively.", "FIGS.", "141-143 and 150-155 illustrate various embodiments of an augment or mounting member 1150 incorporating a variable locking angle screw geometry.", "One specific embodiment of a variable locking angle screw geometry is provided by the Peri-Lock™ system, but it will be understood that various embodiments described herein may be used with any appropriate variable locking angle fixation systems.", "FIG.", "151 shows some embodiments similar to those shown in FIG.", "150, wherein an augment and a mounting member is attached or positioned proximate an acetabular shell, cage, or other augment.", "For example, augment 1350 is positioned proximate shell 1358 and comprises a mounting structure 1352 thereon for accepting an optional fracture reduction plate 1354.The fracture reduction plate 1354 may come in various configurations and may be adapted to be shaped, bent, or cut to fit an area of pelvic bone surrounding the acetabulum.", "The fracture reduction plate 1354 may comprise screw holes 1356 and/or other mounting structures such as spikes protruding therefrom for instant securing to the bone.", "Screw holes 1356 are variable low-profile holes that allow for locking at a variety of angles, but may also be threaded, unthreaded, or partially threaded, and may be fixed or polyaxial.", "The spikes may comprise barbed structures to increase pull-out strength and/or temporarily position and secure the fracture reduction plate to the bone while bone screws are subsequently introduced.", "One or more outer portions of the augment 1350 may have recesses for introducing a cutting member to facilitate removal of the augment 1350 using any of the methods described above.", "In some embodiments, screws or fixation members used in connection with any of the embodiments described herein may comprise fully or partially polymeric heads.", "In some embodiments, the polymeric heads may be comprised of PEEK material, which deforms when inserted into screw holes having engagement features such as tabs, projections, partial threads, full threads, tapers, splines, ridges, steps, or any other mechanical locking structures or combinations thereof provided in the screw holes.", "Portions of the screws, such as heads or shank portions, or the entire screw itself may comprise a polymer, for example, a bioresorbable polymer material or a shape-memory polymer material.", "One example of such material is provided by PolyNovo Biomaterials Limited.", "FIG.", "156 shows a portion of a screw head 1170 according to some embodiments that comprises a polymer that is deformed by an engagement structure 1172 provided on an augment or mounting member.", "Additionally or alternatively, screws or fixation members used in connection with any of the embodiments described herein may be cannulated or otherwise provided with one or more holes, apertures, recesses, grooves, or channels adapted for injecting a material therein.", "For example, the screws or fixation members may be configured for placement of a reinforcement cement or polymer, such as for example, injectable polyurethane, within the screw and to surrounding adjacent areas of bone.", "See, for example, U.S. Pat.", "No.", "7,338,493, U.S. Patent Application Publication No.", "2009/0157078, and International Patent Publication No.", "WO/2010040573, all of which are incorporated by reference herein in their entireties.", "Many different locking configurations may be used between screws or fixation members and the augments and mounting members described herein.", "Non-limiting examples of potential locking mechanism connections are shown and described in U.S. Patent Application Publication No.", "2002/0147499 and U.S. patent application Ser.", "No.", "12/069,331, all of which are incorporated by reference herein in their entireties.", "See also, FIGS.", "141-156.As shown in FIG.", "157, in some embodiments, a porous outer layer 1180 comprising symmetric particles, asymmetric particles, beads, hydroxyapatite, plasma-sprayed chemically-etched surface textures, combinations thereof, or the like is applied to the solid substrate 1182.This porous outer layer 1180 is intended to allow bone ingrowth in order to help achieve better fixation of the component.", "A solid substrate 1182 beneath the porous coating provides relatively better strength to the engagement structure 1184 than if the engagement structure 1184 was formed directly in a porous substrate or the porous outer layer 1180.FIG.", "157 shows a crescent-shaped augment 1186 with large windows.", "FIG.", "158 shows a solid insert 1190 pressed into a fully-porous mounting member or augment 1192 according to some embodiments.", "The insert 1190 comprises an engagement structure 1194 that cooperates and forms a locking engagement with a polyaxial screw head 1196.In some embodiments, the insert such as insert 1190 may be integrally formed with a porous structure (e.g., porous structure 1192) using a rapid manufacturing process, for example, selective laser sintering.", "In some embodiments, the insert may be formed as a separate component that is pressed into the body of the augment or mounting member.", "In such cases, the insert may be formed of a material that is dissimilar with the body of the mounting member or augment.", "For example, the insert may comprise a soft material, such as for example, UHMWPE, PEEK, any other suitable polymer, or combinations thereof, which is configured to deform and lock with a threaded screw head to prevent screw “back-out.” FIG.", "159 schematically illustrates an augment 1200 shaped in the form of an “L” according to some embodiments.", "FIGS.", "163-165 illustrate various bone screws or other attachment mechanisms or fasteners that may be used to secure the various embodiments described herein.", "As background, FIGS.", "160 and 161 schematically demonstrates the difference in bone density and strength between normal bone (FIG.", "160) and osteoporotic bone (FIG.", "161), which may be present in the acetabular or pelvic bone of a patient undergoing revision hip surgery.", "FIG.", "162 schematically illustrates a conventional 6.5 mm cancellous bone screw 1202 having an inner root thread diameter 1204 and an outer crest thread diameter 1206 of 6.5 mm.", "FIGS.", "163-165 show several embodiments of improved cancellous bone screws 1210-1212 that may be used with the various mounting members or augments described herein and shown in the drawings, and which are optimally-configured for use in revision surgeries, particular acetabular and pelvic reconstruction.", "FIG.", "163 schematically illustrates an improved cancellous bone screw 1210 comprising a proximal outer straight thread portion 1214 and a distal tapering thread portion 1216 with a transition region 1218 therebetween.", "The proximal outer straight thread portion 1214 comprises an outer crest thread diameter 1215 between approximately 6.5 mm and 10 mm, for instance, 8.5 mm.", "The thread then tapers down to 6.5 mm as the thread approaches the distal tip 1220 of the screw.", "FIG.", "164 schematically illustrates an improved cancellous bone screw 1211, according to some embodiments having a similar inner root thread diameter as prior cancellous bone screws (e.g., inner root thread diameter 1204) and an outer crest thread diameter 1222 that is between approximately 6.5 mm and 10 mm, for instance, 8.5 mm.", "The larger outer diameter 1222 secures better purchase in osteoporotic bone.", "Moreover, in revision hip surgery, previous screw holes may create large bone voids which may reduce the pullout or holding strength of conventional 6.5 mm cancellous bone screws.", "FIG.", "165 schematically illustrates an improved cancellous bone screw 1212, according to some embodiments, comprising a fully tapered thread 1224 that reduces in diameter as the thread approaches a distal tip 1226 of the screw.", "Proximally, the thread has an outer crest thread diameter 1228 between approximately 6.5 mm and 10 mm, for instance, 8.5 mm.", "The thread tapers distally to a lesser outer crest thread diameter 1230, for instance, 7.5 mm.", "The taper angle may vary and may be non-linear, however, in certain embodiments, it is preferable that the outer crest thread diameter remains greater than 6.5 mm.", "FIGS.", "166-175 show various embodiments of augments that provide features to improve removal of an augment that has been previously positioned in a patient's bone.", "For example, during revision surgery, a surgeon may need to remove an augment positioned during an earlier surgery, which can be particularly difficult in instances where there is bone-ingrowth in, around, and/or through the augment.", "Surrounding bone ingrowth can render augments difficult to remove in subsequent surgeries; thus, providing augments with one or more removal features can be beneficial.", "FIG.", "166 shows an augment 1240 that may be provided with recess portions 1242, which, in this embodiment, are shown alongside a split portion 1244, but which can be provided anywhere on the augment 1240, or even on augments not having a split portion.", "Recess portions 1242 are configured to receive a clamp or other instrument 1246.Recess portions 1242 may be curved or otherwise shaped to correspond to the instrument to be used.", "For removal of the augment 1240, arms 1248 of the instrument 1246 may be inserted into recess portions 1242 in order to securely grasp the augment 1240, squeeze the augment 1240, and pull the augment 1240 from bone.", "The mechanical advantage of the clamp 1246 causes the augment 1240 to squeeze or shut slightly or otherwise flex inwardly, particularly in split augment embodiments, so that the augment 1240 may be removed, even if well fixed in bone.", "The split augment 1240 shown may move from a first position, shown as the outer boundary 1250 in solid lines, to a second compressed position, shown in dotted lines 1252 in a direction shown by inward arrows 1254.This compression allows removal of the augment 1240 in a relatively easier and more efficient manner than chipping away at the augment 1240 or cutting the augment 1240 out in separate portions with a blade.", "Recess portions 1242 and instrument 1246 may also be used to initially position or introduce the augment 1240 into a bone void.", "Once positioned, an expansion member, such as any of the expansion members shown and described herein, may be used to expand and lock the augment 1240 into place.", "Although not shown, it may be desirable to insert plugs or any other appropriate recess portion cover to prevent bone ingrowth therein.", "Alternatively, bone graft material or injectable polymers or any other filler material may be inserted into recess portions, particularly if recess portions are to be used solely for insertion and are not envisioned for use in subsequent removal.", "FIGS.", "167-170 show alternate augment removal options.", "In FIG.", "167, the augment 1260 is shown as provided with a slot 1262 that is shaped to correspond to an appropriate removal tool.", "In this embodiment, the slot 1262 is built into the augment 1260 which can be used with a burr tool 1264.The burr removal tool 1264 is shown having a fixed stop 1266 that corresponds to the curvature or contour of the augment 1260.The augment 1260 of this embodiment provides surface area for bone ingrowth, but also provides room for a removal tool, which can be used to mill out areas of the augment 1260 that are well fixed into bone.", "FIGS.", "168-170 show some embodiments that may be used with a crescent blade or a two-sided blade that can rotate in the slot in order to affect removal.", "The blade is inserted into an augment and then turned or rotated, which allows the blade cut away adjacent ingrown bone and/or to securely “grab” the augment for removal.", "FIG.", "171 shows an augment 1270 for use with a blade removal tool 1272.The opening or slot 1274 of the augment 1270 of this embodiment is shaped to correspond to removal tool 1272.The removal tool 1272 may be inserted completely into and through the augment 1270 such that it extends out the other end of the augment 1270.Alternatively, the removal tool 1272 may be inserted into an opening that also has a quarter-shaped or other shaped turn configured inside the opening that allows the removal tool to be inserted, rotated inside the opening, for example 15° or 20°, and then removed to pull the augment out.", "FIGS.", "172 and 173 show a removal tool 1276 that may comprise a collapsible blade.", "FIG.", "174 shows certain embodiments of an augment pre-designed for removal.", "The augment is provided with one or more removal features comprising recesses, channels, or grooves on the outside of the augment.", "For example, augment 1280 includes channels 1282 on the outside of the augment 1280.It will be understood that removal features may also be positioned in and through the augment as desired.", "The removal features shown allow a blade, scalpel, or other removal instrument to be positioned alongside the augment 1280 or otherwise in the one or more removal portions.", "The removal tool (e.g., tool 1284) may be used to pull or lever the augment 1280 out of its initial position.", "In some embodiments, the removal features may be provided with any type of bone ingrowth prevention surface, in order to prevent bone ingrowth in those particular areas such that they can more easily accept a removal tool.", "FIG.", "175 shows certain embodiments of an augment pre-designed for removal.", "The augment is configured to receive a removable pivot member 1290.In some embodiments, the removable pivot member 1290 has a threaded shank and a convex or ball-shaped head 1292 that acts as a pivot point for a removal instrument 1294.When the removable pivot member 1290 is inserted into an opening 1296 in the augment 1298, the ball-shaped head 1292 provides a fulcrum or pivot point for removal instrument 1294, which, in some embodiments, is configured with a concave receiving portion 1295.In use, concave receiving portion 1295 articulates against convex head 1292, providing a removal force.", "The surgeon may move the instrument 1294 around the augment 1298, using a can opener-type action, in order to lever the augment 1298 out of the bone.", "FIG.", "176 shows a contact-reducing augment according to some embodiments.", "In some surgeries, it may be desirable to limit the amount of contact that metal has with bone, for example, if a patient has metal sensitivity or allergy.", "The T-shaped augment 1300 shown in FIG.", "176 provides a reduced number of contact points with a patient's natural bone.", "The augment 1300 may be secured to a shell/cage or other augment disposed in acetabulum 1302 in any way, including those currently known as well as those described herein.", "However, this augment 1300 has open spaces between bone-contacting points.", "Once positioned, open spaces may be filled with bone graft material, such as allograft, bone paste, putty, or cements, with polyurethane graft materials, such as an injectable material, or any other specific material or combination thereof that the particular surgeon uses to pack bone voids.", "Filler materials may include, for example, calcium phosphate and/or bone morphogenic proteins (BMPs).", "One benefit provided by this design is that it provides a support to keep a shell/cup/augment in place or otherwise stable at points within the bone void without providing full contact with metal along the entire bone void.", "The embodiment shown is a T-shaped augment 1300, but it will be understood that any appropriate augment having one or more contact points but providing a reduced contact surface in general should be considered within the scope of the embodiment.", "For example, a “jacks”-shaped augment having a plurality of offshoots from a central region may be utilized.", "FIG.", "177 shows an augment having one or more coated portions 1312 according to some embodiments.", "The augment 1310 may be fully coated or may have only strips or patches or select areas that are coated.", "This embodiment may be useful for patients having a metal allergy or reaction or any other time a surgeon wishes to fill a space with a material other than with completely metal augment.", "The coating 1312 may be overmolded polyurethane, hydroxyapatite, any other appropriate coating, or any combination thereof.", "FIGS.", "178 and 179 illustrate some embodiments of anchor screws adapted for securing an augment, mounting member, or acetabular shell or cage to surrounding bone.", "The screw 1314 has a flared head 1316 which is adapted for being received in a complementary undercut groove or recess in an augment, mounting member, or acetabular shell or cage.", "The anchor screw 1314 may be placed into the bone prior, and then connected to the augment, mounting member, or acetabular shell or cage in-situ, or the anchor screw 1314 may be loosely attached to the augment, mounting member, or acetabular shell or cage, and the augment/mounting member/shell/anchor screw assembly simultaneously inserted into the bone as one unit.", "The tip 1318 of the anchor screw 1314 may be sharp and self-starting/tapping/drilling.", "In some embodiments, as shown, the anchor screw 1314 may be tapered along one or more portions of its length.", "Large diameter threads may be employed to engage more bone and to prevent the anchor screw from stripping or pulling out.", "In some embodiments, one or more portions of the thread pattern, for example in some embodiments, regions proximal to the head, may be finer than other thread portions as desired to better engage cortical bone portions.", "The screw anchor 1314 may be formed of a solid or porous material, such that it provides stability when it is anchored in place, and also provides long-term fixation because bone will be encouraged to grow into any portions of porous material.", "Moreover, by making one or more portions of the anchor screw 1314 porous, the modulus of elasticity may be more closely matched with surrounding bone as compared to a solid material, and the anchor screw 1314 may provide better initial fixation and overall stability of an adjoining or integral augment, for example.", "In some embodiments, the anchoring screw 1314 may be provided as an integral portion of an augment.", "In other words, a larger augment body may form a portion of the head or shank of the anchor screw.", "The anchor screw may also be configured for reconnecting soft tissues to bone.", "as shown in FIG.", "181.FIG.", "179 illustrates an alternative embodiment of an anchor screw 1321 comprising a split tip 1320, which is configured to deform radially-outwardly to resist pull-out and/or prevent stripping out of the bone.", "FIGS.", "180 and 181 schematically illustrate that once an anchor screw 1326 is screwed into place, another smaller nail or screw 1322 may then be inserted in a cannulated portion of the anchor screw 1326.The use of the smaller nail 1322 can be two fold, for example, to (1) split open the end of the anchor screw 1326 and/or (2) help secure soft tissues (e.g., soft tissue 1324).", "In certain embodiments, an anchor screw may generally resemble a drywall anchor screw.", "FIGS.", "182 and 183 illustrate certain embodiments of an anchor screw 1330 that is configured to be used to secure a graft material, such as bone graft, allograft, or resorbable mesh, to a bone defect.", "FIG.", "184 shows a fastener 1342 that provides a porous shaft 1340 according to some embodiments.", "The porous shaft 1340 may encourage bone ingrowth into the fastener 1342.The fastener itself may serve as a porous augment or it may be used to secure any of the embodiments described herein.", "FIGS.", "185-187 show certain embodiments of augments in the shape of an acetabular cup (also referred to as an “acetabular shell,” “shell,” “cage,” or “cup”) provided with a number of openings disposed circumferentially around the augment.", "For example, augment 1400 has openings 1402, augment 1404 has openings 1406, and augment 1408 has opening 1410.Any number of openings may be provided in the augment, and the openings may be of any shape or size.", "The embodiments of FIGS.", "185 and 186 include multiple openings 1402 and 1406, while embodiments according to FIG.", "187 may have a single opening 1410, which as shown is relatively larger than openings 1402 and 1406.The openings receive complementary-shaped inserts which serve to secure the augment in the acetabulum.", "The openings and inserts may be of any complementary shape (e.g., circular, rectilinear, semi-hemispherical, wedge-shaped, etc.)", "and are not limited to those shapes shown in the Figures.", "FIGS.", "188-198 illustrate various embodiments of inserts that may be positioned in the openings of the augments of FIGS.", "185-187.FIGS.", "188-190 and FIGS.", "191-193 illustrate embodiments of triangular-shaped inserts 1412-1414 and curved inserts 1420-1422, respectively, provided with screw holes to receive screws.", "Any number of screw holes may be provided on inserts and such holes may be provided in any location on the insert to have any trajectory.", "In FIGS.", "188 and 193, three screw holes 1415 are provided on insert 1412 and three screw holes 1425 are provided on insert 1422.In FIG.", "192, two screw holes 1424 are provided on insert 1421.In FIGS.", "189-191 a single screw hole is provided (e.g., screw hole 1416, 1417, and 1423), which can be, but does not have to be, located asymmetrically on the insert as shown in FIGS.", "189 and 191.The screw holes may be smooth, tapered, or threaded and may extend through the insert at any appropriate angle.", "In FIGS.", "194 and 195, a spike 1428 extends from the insert 1430.Alternatively or additionally, as shown in FIGS.", "196 and 197, various types of screw threads 1432 may be formed integrally with, or be otherwise fixed to, an insert 1434 and extend from a surface thereof.", "Surfaces of the inserts may be grooved or etched to increase the surface area for cement fixation (e.g., as illustrated by surface 1436 of FIG.", "194) or may be porous to facilitate bone ingrowth (e.g., as illustrated by surface 1419 FIG.", "190).", "FIG.", "198 shows the back of an insert 1438 provided with a mounting feature 1439 onto which supplemental augments or mounting members (e.g., flanges, blades, hooks, plates, etc.)", "may be mounted according to some embodiments.", "The mounting feature 1439 of insert 1438 may be provided, for example, as a male dovetail or other shape and the supplemental augment may have a complementary track.", "For example, as shown in FIG.", "199, supplemental augment 1440 has complementary track 1442.The male mounting feature 1439 of insert 1438 is positioned in the track 1442 and the supplemental augment 1440 positioned relative to the insert 1438 by translating the male mounting feature 1439 of the insert 1438 in the track 1442.In some embodiments, a supplemental augment may be provided with an opening (rather than a track) that corresponds to the shape of the mounting feature extending from the insert, such as mounting feature 1439.The supplemental augment may be mounted on the insert by inserting the mounting feature of the insert into the opening on the supplemental augment and retained thereon such as via taper lock or other mechanical retention methods.", "In use, an appropriate insert (which is selected in part to suit the anomalies and defects of a particular anatomy) is positioned and retained in an opening such as one of openings 1402, 1406, and 1410 of FIGS.", "185-187, and the augment/insert assembly is positioned in the acetabulum.", "In some embodiments, an insert and an opening may form a taper lock (e.g., as illustrated by taper lock 1444 of FIG.", "200) or friction fit to lock the insert in the opening.", "In some embodiments, as shown in FIG.", "201, for example, a ledge 1446 may be provided around at least a portion of an opening 1448 on the outer wall of the augment 1450 so as to extend partially into the opening 1448.An insert 1447 is positioned in the opening 1448 and the ledge 1446 prevents the insert 1447 from passing through the opening 1448 and retains the insert 1447 within the opening 1448.Inserts need not be provided in every opening of the augment but rather may be strategically placed during surgery.", "If the inserts of FIGS.", "188-193 are used, screws are positioned in the screw hole(s) of the insert and engage surrounding bone to secure the augment in place.", "The screws can be any appropriate fastener, including but not limited to polyaxial screws.", "If the inserts of FIGS.", "194-197 are used, the spike (e.g., spike 1428) or screws (e.g., screw 1432) penetrate bone to secure the augment in place.", "The augment itself may include at least one screw hole (e.g., center hole 1401 in FIG.", "185) through which a screw may extend to further secure the augment in place.", "Cement may be provided over or within the augment to fill the openings of the augment not provided with an insert for fixation of the augment to backside bone voids, and a shell or liner may be cemented into the augment in a desired orientation.", "The features describe above may be applied to augments other than cup-shaped augments, as well as mounting members such as bone plates.", "For example, as shown in FIG.", "202, in addition to or in lieu of traditional screw holes, openings 1454 and 1456 may be provided in a bone plate 1452 and correspondingly-shaped inserts (such as those shown in FIG.", "188-197) positioned in the plate 1452 to secure the plate 1452 to bone, as described above.", "FIG.", "203 illustrates some embodiments of inserts that may be provided in the openings of the augments of, for example, FIGS.", "185-187.Lattice structure is provided on the inserts (e.g., lattice structure 1460 of insert 1462).", "The inserts may have different amounts and configurations of lattice structure (e.g., some lattices may be large, small, deep, shallow, offset, etc.).", "The inserts may include a port (e.g., port 1464 of insert 1462) that extends through the insert.", "In use, the insert is secured in the augment (as discussed above), and the augment positioned so that the lattice structure of the insert extends into a bone void such as bone void 1466.A bone cement, injectable polymer (e.g., polyurethane) or bio-resorbable material is injected into the bone void and around the lattice structure via the port in the insert.", "For example, an injector 1465 may be used to deposit an injectable curing material 1467, which may be one of the materials listed above, into lattice structure 1460 through port 1464 of insert 1462.The lattice structure serves to reinforce the injected material after curing/setting.", "In FIGS.", "204 and 205, a supplemental augment 1470 (shown in isolation in FIG.", "205) is coupled to an augment 1472 (referred to here as the “primary augment” to avoid confusion) such as shown in FIGS.", "185-187.A tongue 1471 extends from the supplemental augment 1470 and is of complementary shape to the opening in the primary augment 1472.The tongue 1471 is inserted into the opening of the primary augment 1472 to orient the supplemental augment 1470 properly relative to, and to retain the supplemental augment 1470 on, the primary augment 1472.In one possible use, the primary augment 1472 with attached supplemental augment 1470 is positioned adjacent a bone void in the acetabulum such that the flange 1473 of the supplemental augment 1470 extends adjacent healthy bone.", "Screws or other fixation means may be inserted through the flange 1473 to attach the primary 1472 and supplemental 1470 augment to bone and thereby retain the primary augment 1472 in position within the acetabulum.", "In some embodiments, a portion of the supplemental augment 1470 that spans the bone void may be shaped to fill at least a portion of the void.", "FIGS.", "206-208 relate to augments that may be configured to attach to shells or cages with or without cement, and are also configured to allow fine positional adjustments for best bone fit, coverage, and stability.", "The augment can be placed on a periphery of a hemispherical acetabular shell, cage, or augment (a shell 1474 is illustrated).", "As shown in FIG.", "206, the shell 1480 may include a track 1482 that is undercut so as to form a dovetail joint 1481 with the augment.", "The track 1482 may be provided as a J-shaped slot (as shown), T-shaped slot, H-shaped slot, or any other shape involving combinations of straight and/or curved segments.", "The track 1482 preferably includes at least two portions or slots, at least one of which can receive a complementary connecting member from the augment.", "As shown in FIG.", "206, for example, the first portion or slot 1484 and second portion or slot 1486 join about common region 1488 but are separated out at distal ends 1485 and 1487 by angle θ, which is less than 180° in the example.", "The at least two portions thereby permit the augment to be adjustably positioned along the surface of the shell 1480 by sliding the augment (and its connector) along the track and securing it at the desired location.", "For example, the augment could be secured in one of the at least two portions (such as slot 1484), or the other of the at least two portions (such as slot 1486), or in between.", "As shown in FIG.", "207, the augment 1474 may include a channel 1475 that is shaped to receive a connecting member.", "In the illustrated embodiment of FIG.", "208, the connecting member 1476 is a “V” button but connecting members having other shapes are contemplated.", "One side of the V button 1476 is positioned in the channel 1475 of the augment 1474, and the other side of the V button 1476 engages the track 1482 on the shell 1480 to thereby couple the augment 1474 to the shell 1480 and allow for variable positioning of the augment 1474 relative to the shell 1480.While the augment 1474 may be mechanically retained to the shell 1480 in this way, it also may be cemented to the shell 1480.To facilitate such retention, surfaces of the augment 1474 and/or shell 1480 may be textured to facilitate adherence of the cement on the augment 1474 and/or shell 1480.FIG.", "209 shows a “7-graft” type augment 1477 that spans a pelvic defect that enables screw fixation into the posterior portion of the pelvis.", "The augment includes an upraised portion 1478 for positioning adjacent a portion of the shell 1489 and an elongate portion 1479 for spanning a bone void or other pelvic defect 1490 and affixing to the sidewall of the pelvis into healthy bone (such as via screws) to thereby retain the shell in the acetabulum.", "The upraised portion 1478 can be affixed directly to the shell 1489 (such as via mechanical fixation methods such as screws) or can be cemented or otherwise adhered to the shell 1489.FIG.", "210 illustrates a secondary augment 1490 for use with a primary augment.", "In use, the secondary augment 1490 is attached or coupled to the primary augment so as to extend off the primary augment.", "Bone surrounding the primary augment (such as the ischium) is prepared to received the secondary augment 1490, for example, at locations 1494 or 1496.In some embodiments, the ischium is reamed and the secondary augment 1490 is seated in the reamed out bone.", "In this way, the secondary augment 1490 helps to anchor the primary augment in the proper position within the acetabulum.", "The secondary augment 1490 is illustrated as conical in shape but can be of any shape suitable to accomplish its intended purpose.", "The secondary augment 1490 can be chemically (such as via adhesive) or mechanically (such as via screws) attached to the primary augment in any way, including those described herein.", "By way only of example, inserts (such as, but not limited to, those illustrated in FIGS.", "194-198) may be positioned in the primary augment or shell (as described above) and the secondary augment 1490 may attach to the mounting structure provided on those inserts to thereby couple the secondary augment 1490 to the primary augment.", "Again, however, any coupling method is contemplated.", "In some embodiments, the secondary augment 1490 includes a wing 1492 to impart more stability to the primary/secondary augment construct.", "The foregoing is merely illustrative of the principles of the disclosure, and the systems, devices, and methods can be practiced by other than the described embodiments, which are presented for purposes of illustration and not of limitation.", "It is to be understood that the systems, devices, and methods disclosed herein, while shown for use in acetabular systems, may be applied to medical devices to be used in other surgical procedures including, but not limited to, spine arthroplasty, cranio-maxillofacial surgical procedures, knee arthroplasty, shoulder arthroplasty, as well as foot, ankle, hand, and extremities procedures.", "Variations and modifications will occur to those of skill in the art after reviewing this disclosure.", "The disclosed features may be implemented, in any combination and subcombinations (including multiple dependent combinations and subcombinations), with one or more other features described herein.", "The various features described or illustrated above, including any components thereof, may be combined or integrated in other systems.", "Moreover, certain features may be omitted or not implemented.", "Examples of changes, substitutions, and alterations are ascertainable by one skilled in the art and could be made without departing from the scope of the information disclosed herein.", "All references cited herein are incorporated by reference in their entirety and made part of this application." ] ]
Patent_15872599
[ [ "PORTED CATHETER ADAPTER WITH INTEGRATED SEPTUM ACTUATOR RETENTION", "A ported catheter adapter and septum actuator having various features to prevent displacement and dislodging of the septum actuator when accessing the patient's vasculature via the inserted infusion device.", "In particular, the systems and methods of the present invention provide an intravenous infusion device incorporating a septum actuator with a retention tab that interacts with a retention ring that is incorporated into the valve of a side port.", "This interaction retains the septum actuator within the lumen of the catheter adapter, thereby allowing for subsequent access to the patient's vasculature." ], [ "1.A ported catheter assembly, comprising: a catheter adapter having a proximal end, a distal end and a lumen extending therebetween, the catheter adapter further comprising a side port forming a pathway through a sidewall of the catheter adapter and in communication with the lumen; a blood control septum disposed within the lumen and dividing the lumen into a proximal chamber and a distal chamber; a septum actuator having an outer diameter and disposed within the proximal chamber and having a base, a tip and a body extending therebetween; an actuator retention tab having an outer diameter and positioned on an outer surface of the body; and a valve disposed within the lumen and forming a seal between the lumen and the pathway of the side port, the valve having a retention ring comprising an inner diameter that is greater than the outer diameter of the septum actuator and less than the outer diameter of the actuator retention tab, wherein the retention ring is positioned between the side port and the blood control septum, wherein the actuator retention tab is positioned on the outer surface of the body distally to the retention ring and at a position between the retention ring and the blood control septum such that rigidity is provided to a portion of the valve between the side port and the blood control septum and a proximal end of the valve collapses in response to fluid being injected into the side port.", "2.The assembly of claim 1, wherein the valve comprises a flexible tube having an outer diameter that is approximately the same size as an inner diameter of the lumen, whereby the valve is retained within the lumen by an interference fit.", "3.The assembly of claim 1, wherein the proximal end of the catheter adapter further comprises an opening through which a separate device may be inserted to contact the base of the septum actuator and advance the tip of the septum actuator through a slit of the blood control septum.", "4.The assembly of claim 1, wherein the retention ring is a first retention ring, wherein the valve further comprises a second retention ring, wherein the wherein the base comprises an outer diameter that is greater than the inner diameter of the second retention ring.", "5.The assembly of claim 4, wherein the second retention ring further comprises a plurality of vents.", "6.The assembly of claim 4, wherein when the base contacts the second retention ring, the tip of the septum actuator is advanced through a slit of the septum and the interface between the base and the second retention ring prevents the tip of the septum actuator from further advancement through the slit.", "7.The assembly of claim 4, wherein the second retention ring is disposed at a proximal end of the valve.", "8.The assembly of claim 1, further comprising an antimicrobial coating applied to the actuator retention tab, wherein the actuator retention tab is positioned within a fluid pathway through the lumen of the catheter adapter.", "9.The assembly of claim 8, wherein the antimicrobial coating comprises an antimicrobial agent selected from the group consisting of chlorhexidine diacetate, chlorhexidine gluconate, alexidine, silver sulfadiazine, silver acetate, silver citrate hydrate, cetrimide, cetyl pyridium chloride, benzalkonium chloride, o-phthalaldehyde, and silver element.", "10.The assembly of claim 8, wherein the antimicrobial coating comprising an eluting antimicrobial coating whereby the eluting antimicrobial coating provides a zone of inhibition within a fluid within the lumen of the catheter adapter.", "11.The assembly of claim 1, wherein the tip is positioned proximate to the blood control septum and the base is positioned proximate to the proximal end of the catheter adapter.", "12.A ported catheter assembly, comprising: a catheter adapter having a proximal end, a distal end, and a lumen extending therebetween, the catheter adapter further comprising a side port forming a pathway through a sidewall of the catheter adapter and in communication with the lumen; a blood control septum disposed within the lumen and dividing the lumen into a proximal chamber and a distal chamber; a septum actuator having an outer diameter and disposed within the proximal chamber and having a base, a tip and a body extending therebetween, the actuator having a vent forming a fluid pathway through a sidewall of the septum actuator; an actuator retention tab having an outer diameter and positioned on an outer surface of the body; and a valve disposed within the lumen and forming a seal between the lumen and the pathway of the side port, the valve having a first retention ring comprising an inner diameter that is greater than the outer diameter of the septum actuator and less than the outer diameter of the actuator retention tab, the valve having a second retention ring being disposed at a proximal end of the valve.", "13.The assembly of claim 12, wherein the base comprises an outer diameter that is greater than an inner diameter of the second retention ring.", "14.The assembly of claim 13, wherein when the base contacts the second retention ring, the tip of the septum actuator is advanced through a slit of the septum and the interface between the base and the second retention ring prevents the tip of the septum actuator from further advancement through the slit.", "15.The assembly of claim 12, wherein the valve comprises a flexible tube having an outer diameter that is approximately the same size as an inner diameter of the lumen, whereby the valve is retained within the lumen by an interference fit.", "16.The assembly of claim 12, wherein the proximal end of the catheter adapter further comprises an opening through which a separate device may be inserted to contact the base of the septum actuator and advance the tip of the septum actuator through a slit of the blood control septum.", "17.The assembly of claim 12, wherein the second retention ring further comprises a plurality of vents.", "18.The assembly of claim 12, further comprising an antimicrobial coating applied to the actuator retention tab, wherein the actuator retention tab is positioned within a fluid pathway through the lumen of the catheter adapter.", "19.The assembly of claim 18, wherein the antimicrobial coating comprises an antimicrobial agent selected from the group consisting of chlorhexidine diacetate, chlorhexidine gluconate, alexidine, silver sulfadiazine, silver acetate, silver citrate hydrate, cetrimide, cetyl pyridium chloride, benzalkonium chloride, o-phthalaldehyde, and silver element.", "20.The assembly of claim 18, wherein the antimicrobial coating comprising an eluting antimicrobial coating whereby the eluting antimicrobial coating provides a zone of inhibition within a fluid within the lumen of the catheter adapter." ], [ "<SOH> BACKGROUND <EOH>Intravenous infusion systems are commonly used to access the vasculature of a patient as part of an infusion therapy procedure.", "An intravenous infusion system generally includes a fluid reservoir of IV bag that is connected to the patient via an intravenous catheter.", "The catheter is commonly coupled to a catheter adapter having a Luer-lock connector, or other connector-type for coupling the catheter adapter to a syringe, a section of intravenous tubing, or some other external Luer device.", "Fluid from the IV bag flows into the patient via the catheter adapter and the intravenous catheter.", "In some instances, the catheter adapter further includes a blood control septum that is positioned within a fluid pathway running though the catheter adapter.", "The blood control septum is provided to allow selective flow of fluid through the fluid pathway.", "For example, the blood control septum may include a slit that may be bypassed when an external Luer device is coupled to the catheter adapter and directly engaging the septum.", "Upon removing the external Luer device, the slit is closed to prevent blood from leaking out of the catheter adapter.", "In some instances, the catheter adapter further includes a septum actuator that is contacted by the external or secondary infusion device, such as a Luer device, and advanced through the slit of the septum.", "The septum actuator is generally advanced through the septum to provide a temporary pathway through the septum.", "Upon removal of the secondary infusion device, the resilient nature of the septum backs the septum actuator out of the septum slit.", "In some instances, the septum actuator is accidentally dislodged and displaced from the proximal opening of the catheter adapter, thereby preventing subsequent advancement through the septum.", "In this instance, the infusion device must be removed from the patient and replaced with a new device.", "Not only does this create an inconvenience for the care provider, this also results in increased risk of infection and trauma to the patient as a second catheterization is now required.", "Thus, while systems and methods currently exist to bypass a blood control septum as part of an infusion procedure, challenges still remain.", "Accordingly, it would be an improvement in the art to augment or replace current techniques with the system and methods discussed herein." ], [ "<SOH> BRIEF SUMMARY OF THE INVENTION <EOH>The present invention has been developed in response to problems and needs in the art that have not yet been fully resolved by currently available systems and methods.", "Thus, these systems and methods are developed to provide a ported catheter adapter and septum actuator having various features to prevent displacement and dislodging of the septum actuator when accessing the patient's vasculature via the inserted infusion device.", "Thus, the systems and methods of the present invention provide an intravenous infusion device incorporating a septum actuator with a retention tab that interacts with a retention ring that is incorporated into the valve of a side port.", "This interaction retains the septum actuator within the lumen of the catheter adapter, thereby allowing for subsequent access to the patient's vasculature.", "In some implementations, a ported catheter assembly is provided comprising a catheter adapter having a proximal end, a distal end and a lumen extending therebetween, the catheter adapter further comprising a side port forming a pathway through a sidewall of the catheter adapter and in communication with the lumen.", "The catheter assembly further comprises a blood control septum disposed within the lumen and dividing the lumen into a proximal chamber and a distal chamber.", "In some instances, the device further includes a septum actuator having an outer diameter and disposed within the proximal chamber and having a base, a tip and a body extending therebetween.", "The tip is positioned proximate to the blood control septum and the base is positioned proximate to the proximal end of the catheter adapter.", "The catheter assembly further comprises an actuator retention tab having an outer diameter and being positioned on an outer surface of the septum actuator body.", "The device further comprises a valve disposed within the lumen and forming a seal between the lumen and the pathway of the side port.", "In some instances, the valve includes a retention ring comprising an inner diameter that is greater than the outer diameter of the septum actuator and less than the outer diameter of the actuator retention tab, wherein the actuator retention tab is positioned on the outer surface of the septum actuator body between the blood control septum and the actuator retention ring.", "The valve of the side port generally comprises a flexible tube having an outer diameter that is approximately the same size as an inner diameter of the lumen, whereby the valve is retained within the lumen by an interference fit.", "The proximal end of the catheter adapter further comprises and opening through which a separate device may be inserted to contact the base of the septum actuator and advance the tip of the septum actuator through a slit of the blood control septum.", "In some instances, the base comprises an outer diameter that is greater than the inner diameter of the actuator retention ring.", "As such, the base is prevented from passing through the actuator retention ring.", "In other instances, the actuator retention ring further comprises a plurality of vents, each vent having a surface area that is selected to prevent or permit passage or air and/or fluid.", "In some implementations, the retention tab is spaced from the base of the septum actuator at a distance such that when the base contacts the retention ring the tip of the septum actuator is advanced through the slit of the septum, and the interface between the base and the actuator ring prevents the tip of the septum from further advancement through the slit.", "In other embodiments, the actuator retention ring is spaced from the base at a first distance, such that when the base contacts the retention ring, the tip of the septum actuator is advance through the septum slit and the interface between the base and the actuator retention ring prevents the tip of the septum actuator from further advancement through the slit.", "In some instances, the first distance is approximately equal to a second distance between a distal most surface of the tip of the septum actuator and a distal most surface of the blood control septum when the actuator retention tab is in contact with the actuator retention ring.", "In some implementations, an antimicrobial coating is applied to one or more surfaces of the infusion therapy device.", "In one instance, an antimicrobial coating is applied to the septum actuator retention tab, wherein the septum actuator retention tab is positioned within a fluid pathway through the lumen of the catheter adapter.", "The antimicrobial coating further includes an antimicrobial agent that is compatible for use in an infusion therapy device.", "Non-limiting examples of suitable antimicrobial agents include chlorhexidine diacetate, chlorhexidine gluconate, alexidine, silver sulfadiazine, silver acetate, silver citrate hydrate, cetrimide, cetyl pyridium chloride, benzalkonium chloride, o-phthalaldehyde, and silver element.", "In some instances, the antimicrobial coating comprises an eluting antimicrobial coating matrix whereby the eluting antimicrobial coating provides a zone of inhibition within a fluid within the lumen of the catheter adapter.", "Some implementations of the present invention further include an actuator retention tab device comprising an inner surface configured to receive an outer surface of a septum actuator and be fixedly attached thereto; an outer surface positioned opposite the inner surface and in communication with a fluid pathway of a lumen of the catheter adapter, the outer surface having an outer diameter that is greater than an inner diameter of an actuator retention ring of the catheter adapter, whereby the actuator retention tab is prevented from passing through the actuator retention ring.", "In some instances, the outer surface of the actuator retention tab is further coated with an antimicrobial coating.", "These and other features and advantages of the present invention may be incorporated into certain embodiments of the invention and will become more fully apparent from the following description and appended claims, or may be learned by the practice of the invention as set forth hereinafter.", "The present invention does not require that all the advantageous features and all the advantages described herein be incorporated into every embodiment of the invention." ], [ "RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "14/597,032, filed Jan. 14, 2015, and entitled PORTED CATHETER ADAPTER WITH INTEGRATED SEPTUM ACTUATOR RETENTION, which claims priority to U.S.", "Provisional Patent Application Ser.", "No.", "61/929,686, filed Jan. 21, 2014, and entitled PORTED CATHETER ADAPTER WITH INTEGRATED SEPTUM ACTUATOR RETENTION, which are incorporated herein in their entirety.", "BACKGROUND Intravenous infusion systems are commonly used to access the vasculature of a patient as part of an infusion therapy procedure.", "An intravenous infusion system generally includes a fluid reservoir of IV bag that is connected to the patient via an intravenous catheter.", "The catheter is commonly coupled to a catheter adapter having a Luer-lock connector, or other connector-type for coupling the catheter adapter to a syringe, a section of intravenous tubing, or some other external Luer device.", "Fluid from the IV bag flows into the patient via the catheter adapter and the intravenous catheter.", "In some instances, the catheter adapter further includes a blood control septum that is positioned within a fluid pathway running though the catheter adapter.", "The blood control septum is provided to allow selective flow of fluid through the fluid pathway.", "For example, the blood control septum may include a slit that may be bypassed when an external Luer device is coupled to the catheter adapter and directly engaging the septum.", "Upon removing the external Luer device, the slit is closed to prevent blood from leaking out of the catheter adapter.", "In some instances, the catheter adapter further includes a septum actuator that is contacted by the external or secondary infusion device, such as a Luer device, and advanced through the slit of the septum.", "The septum actuator is generally advanced through the septum to provide a temporary pathway through the septum.", "Upon removal of the secondary infusion device, the resilient nature of the septum backs the septum actuator out of the septum slit.", "In some instances, the septum actuator is accidentally dislodged and displaced from the proximal opening of the catheter adapter, thereby preventing subsequent advancement through the septum.", "In this instance, the infusion device must be removed from the patient and replaced with a new device.", "Not only does this create an inconvenience for the care provider, this also results in increased risk of infection and trauma to the patient as a second catheterization is now required.", "Thus, while systems and methods currently exist to bypass a blood control septum as part of an infusion procedure, challenges still remain.", "Accordingly, it would be an improvement in the art to augment or replace current techniques with the system and methods discussed herein.", "BRIEF SUMMARY OF THE INVENTION The present invention has been developed in response to problems and needs in the art that have not yet been fully resolved by currently available systems and methods.", "Thus, these systems and methods are developed to provide a ported catheter adapter and septum actuator having various features to prevent displacement and dislodging of the septum actuator when accessing the patient's vasculature via the inserted infusion device.", "Thus, the systems and methods of the present invention provide an intravenous infusion device incorporating a septum actuator with a retention tab that interacts with a retention ring that is incorporated into the valve of a side port.", "This interaction retains the septum actuator within the lumen of the catheter adapter, thereby allowing for subsequent access to the patient's vasculature.", "In some implementations, a ported catheter assembly is provided comprising a catheter adapter having a proximal end, a distal end and a lumen extending therebetween, the catheter adapter further comprising a side port forming a pathway through a sidewall of the catheter adapter and in communication with the lumen.", "The catheter assembly further comprises a blood control septum disposed within the lumen and dividing the lumen into a proximal chamber and a distal chamber.", "In some instances, the device further includes a septum actuator having an outer diameter and disposed within the proximal chamber and having a base, a tip and a body extending therebetween.", "The tip is positioned proximate to the blood control septum and the base is positioned proximate to the proximal end of the catheter adapter.", "The catheter assembly further comprises an actuator retention tab having an outer diameter and being positioned on an outer surface of the septum actuator body.", "The device further comprises a valve disposed within the lumen and forming a seal between the lumen and the pathway of the side port.", "In some instances, the valve includes a retention ring comprising an inner diameter that is greater than the outer diameter of the septum actuator and less than the outer diameter of the actuator retention tab, wherein the actuator retention tab is positioned on the outer surface of the septum actuator body between the blood control septum and the actuator retention ring.", "The valve of the side port generally comprises a flexible tube having an outer diameter that is approximately the same size as an inner diameter of the lumen, whereby the valve is retained within the lumen by an interference fit.", "The proximal end of the catheter adapter further comprises and opening through which a separate device may be inserted to contact the base of the septum actuator and advance the tip of the septum actuator through a slit of the blood control septum.", "In some instances, the base comprises an outer diameter that is greater than the inner diameter of the actuator retention ring.", "As such, the base is prevented from passing through the actuator retention ring.", "In other instances, the actuator retention ring further comprises a plurality of vents, each vent having a surface area that is selected to prevent or permit passage or air and/or fluid.", "In some implementations, the retention tab is spaced from the base of the septum actuator at a distance such that when the base contacts the retention ring the tip of the septum actuator is advanced through the slit of the septum, and the interface between the base and the actuator ring prevents the tip of the septum from further advancement through the slit.", "In other embodiments, the actuator retention ring is spaced from the base at a first distance, such that when the base contacts the retention ring, the tip of the septum actuator is advance through the septum slit and the interface between the base and the actuator retention ring prevents the tip of the septum actuator from further advancement through the slit.", "In some instances, the first distance is approximately equal to a second distance between a distal most surface of the tip of the septum actuator and a distal most surface of the blood control septum when the actuator retention tab is in contact with the actuator retention ring.", "In some implementations, an antimicrobial coating is applied to one or more surfaces of the infusion therapy device.", "In one instance, an antimicrobial coating is applied to the septum actuator retention tab, wherein the septum actuator retention tab is positioned within a fluid pathway through the lumen of the catheter adapter.", "The antimicrobial coating further includes an antimicrobial agent that is compatible for use in an infusion therapy device.", "Non-limiting examples of suitable antimicrobial agents include chlorhexidine diacetate, chlorhexidine gluconate, alexidine, silver sulfadiazine, silver acetate, silver citrate hydrate, cetrimide, cetyl pyridium chloride, benzalkonium chloride, o-phthalaldehyde, and silver element.", "In some instances, the antimicrobial coating comprises an eluting antimicrobial coating matrix whereby the eluting antimicrobial coating provides a zone of inhibition within a fluid within the lumen of the catheter adapter.", "Some implementations of the present invention further include an actuator retention tab device comprising an inner surface configured to receive an outer surface of a septum actuator and be fixedly attached thereto; an outer surface positioned opposite the inner surface and in communication with a fluid pathway of a lumen of the catheter adapter, the outer surface having an outer diameter that is greater than an inner diameter of an actuator retention ring of the catheter adapter, whereby the actuator retention tab is prevented from passing through the actuator retention ring.", "In some instances, the outer surface of the actuator retention tab is further coated with an antimicrobial coating.", "These and other features and advantages of the present invention may be incorporated into certain embodiments of the invention and will become more fully apparent from the following description and appended claims, or may be learned by the practice of the invention as set forth hereinafter.", "The present invention does not require that all the advantageous features and all the advantages described herein be incorporated into every embodiment of the invention.", "BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS In order that the manner in which the above-recited and other features and advantages of the invention are obtained will be readily understood, a more particular description of the invention briefly described above will be rendered by reference to specific embodiments thereof that are illustrated in the appended drawings.", "These drawings depict only typical embodiments of the invention and are not therefore to be considered to limit the scope of the invention.", "FIG.", "1 is a perspective view of a ported infusion therapy device in accordance with a representative embodiment of the present invention.", "FIG.", "2 is a cross-section, side view of a ported catheter adapter having a retention ring, a septum actuator, and an actuator retention tab, and being shown prior to activation in accordance with a representative embodiment of the present invention.", "FIG.", "3 is a cross-section, side view of a ported catheter adapter having a retention ring, a septum actuator, and an actuator retention tab, and being shown following activation in accordance with a representative embodiment of the present invention.", "FIG.", "4A is a cross-section rear view of a ported catheter adapter showing a cross-section of the retention ring in accordance with a representative embodiment of the present invention.", "FIG.", "4B is a cross-section rear view of a ported catheter adapter showing a cross-section of a vented retention ring in accordance with a representative embodiment of the present invention.", "FIG.", "5 is a cross-section side view of a ported catheter adapter having a proximally positioned actuator retention ring and undergoing injection of a fluid via the catheter port in accordance with a representative embodiment of the present invention.", "FIG.", "6 is a cross-section side view of a ported catheter having a distally positioned actuator retention ring in accordance with a representative embodiment of the present invention.", "FIG.", "7 is a cross-section side view of a ported catheter having a distally positioned actuator retention ring and undergoing injection of a fluid via the catheter port in accordance with a representative embodiment of the present invention.", "DETAILED DESCRIPTION OF THE INVENTION The presently preferred embodiments of the present invention can be understood by reference to the drawings, wherein like reference numbers indicate identical or functionally similar elements.", "It will be readily understood that the components of the present invention, as generally described and illustrated in the figures herein, could be arranged and designed in a wide variety of different configurations.", "Thus, the following more detailed description, as represented in the figures, is not intended to limit the scope of the invention as claimed, but is merely representative of presently preferred embodiments of the invention.", "Moreover, the Figures may show simplified or partial views, and the dimensions of elements in the Figures may be exaggerated or otherwise not in proportion for clarity.", "In addition, the singular forms “a,” “an,” and “the” include plural referents unless the context clearly dictates otherwise.", "Thus, for example, reference to a terminal includes reference to one or more terminals.", "In addition, where reference is made to a list of elements (e.g., elements a, b, c), such reference is intended to include any one of the listed elements by itself, any combination of less than all of the listed elements, and/or a combination of all of the listed elements.", "The term “substantially” means that the recited characteristic, parameter, or value need not be achieved exactly, but that deviations or variations, including for example, tolerances, measurement error, measurement accuracy limitations and other factors known to those of skill in the art, may occur in amounts that do not preclude the effect the characteristic was intended to provide.", "As used herein, the term “proximal”, “top”, “up” or “upwardly” refers to a location on the device that is closest to the clinician using the device and farthest from the patient in connection with whom the device is used when the device is used in its normal operation.", "Conversely, the term “distal”, “bottom”, “down” or “downwardly” refers to a location on the device that is farthest from the clinician using the device and closest to the patient in connection with whom the device is used when the device is used in its normal operation.", "As used herein, the term “in” or “inwardly” refers to a location with respect to the device that, during normal use, is toward the inside of the device.", "Conversely, as used herein, the term “out” or “outwardly” refers to a location with respect to the device that, during normal use, is toward the outside of the device.", "Referring now to FIG.", "1, a ported infusion therapy device 10 is shown.", "Device 10 generally comprises various features and elements to enable subcutaneous or intravenous infusion of a fluid or medicament into a patient.", "In some instances, device 10 further comprises feature to enable removal of a fluid from a patient, such as blood.", "Device 10 generally comprises a ported catheter adapter 20 having a proximal end 22, a distal end 24 and a lumen 26 extending therebetween.", "In some instances, catheter adapter 20 further comprises a side port 30 forming a pathway through a sidewall of catheter adapter 20 and in communication with lumen 26.A valve 40 (shown in FIGS.", "2-7) is placed within lumen 26 so as to provide a defeatable barrier between side port 30 and lumen 26.Valve 40 generally comprises a resilient, flexible material that is easily deformed when fluid is introduced to port 30 via a syringe or other compatible device.", "For example, in some instances valve 40 comprises silicone, polyisoprene, or a similar polymer material.", "Upon deformation of valve 40, fluid from the syringe is permitted to bypass the deformed valve and flow into lumen 26.As the fluid pressure decreases, the resilient nature of the valve's material causes valve 40 to restore its original shape, thereby once again blocking the fluid pathway.", "Device 10 further comprises a catheter 12 that is coupled to distal end 24 and which is configured for insertion into a patient.", "In some instances, catheter 12 comprises a rigid plastic or metallic material having a sharpened distal end that can pierce the patient's skin and gain access to the vasculature or subcutaneous tissues of the patient.", "In other instance, catheter 12 comprises a flexible material having an inner diameter through which an introducer needle 16 is inserted.", "Introducer needle 16 comprises a rigid metallic material having a sharpened distal end that extends through catheter 12 and is exposed beyond the tip 14 of catheter 12.The introducer needle is capable of piercing the skin to provide access to the vasculature or subcutaneous tissues of the patient.", "Once access is obtained, tip 14 of catheter 12 is inserted through the newly formed opening and into the desired location within the patient.", "Introducer needle 16 is then withdrawn from device 10, and catheter 12 is left disposed within the patient.", "Proximal end 22 further comprises an opening 28 for receiving a secondary infusion therapy device 50, such as a syringe or intravenous fluid line.", "In some instances, proximal end 22 comprises a set of threads configured to threadedly receive the secondary device 50 in a secure manner.", "Opening 28 may further comprise a tapered opening to receive secondary device 50 via an interference or friction fit.", "Proximal end 22 and opening 28 may alternatively comprises various surfaces and other features to enable coupling to a needle hub, a diagnostic device, and other suitable infusion therapy equipment.", "Referring now to FIG.", "2, a cross-section side view of a ported catheter adapter 20 is shown.", "Catheter adapter 20 further comprises a blood control septum 60 that is disposed within lumen 26 towards distal end 24, thereby dividing lumen 26 into proximal 70 and distal 80 fluid chambers.", "Septum 60 may comprise and shape or structure that is compatible with the teachings of the instant invention.", "In some instances, septum 60 comprises a cylindrical structure having a proximal opening 62 and a distal membrane 64 comprising a slit 66.Slit 66 provides a fluid-tight seal, thereby preventing fluid from bypassing septum 60.Septum 60 further comprises a flexible, resilient material that may be selectively deformed to open slit 66 to permit passage of fluids.", "For example, in some embodiments increased fluid pressure within proximal fluid chamber 70 will result in septum 60 being temporarily deformed, thereby permitting fluid within proximal chamber 70 to bypass septum 60 through slit 66 and flow into distal fluid chamber 80.In some instances, valve 40 is positioned within lumen 26 at a positioned between opening 28 and blood control septum 60.Valve 40 may be secured within lumen 26 by any compatible means.", "For example, in some embodiments valve 40 is secured within lumen 26 via an adhesive.", "In other embodiments, valve 40 is secured within lumen 26 via an interference fit.", "Further, in some instances valve 40 is inserted into an annular groove formed on the inner surface of lumen 26.Valve 40 is placed within lumen 26 so as to overlap and form a seal between lumen 26 and the pathway of side port 30.Valve 40 comprises a proximal opening 42, a distal opening 44, and a pathway 46 extending therebetween.", "In some instances, proximal opening 42 comprises a reduced diameter.", "In other embodiments, catheter adapter 20 further comprises a septum actuator 90 that is slidably disposed within proximal fluid chamber 70.Septum actuator 90 comprises a base 92, a tip 94, and a body 96 extending therebetween.", "Septum actuator 90 further comprises a hollow interior through which a fluid may pass.", "In some instances, septum actuator 90 further comprises one or more fluid vents forming a fluid pathway through a sidewall of septum actuator 90 and in communication with lumen 26, thereby providing diverse flow patterns for a fluid passing through lumen 26 and septum actuator 90.Base 92 is generally positioned proximate to opening 28 of catheter adapter 20, thereby being accessible to a secondary infusion therapy device 50.Tip 94 is positioned proximate to septum 60, and in some embodiments is inserted within proximal opening 62 and in direct proximity to membrane 64 and slit 66.Tip 94 is advanced through slit 66 as base 92 is pushed in distal direction 100 by a secondary infusion therapy device 50 that is inserted through opening 28, as shown in FIG.", "3.Upon removal of secondary device 50, the resilient nature of septum 60 causes membrane 64 to restore its original formation, thereby backing tip 94 out of slit 66, and sliding septum actuator 90 in proximal direction 102, thereby restoring the fluid-tight seal of slit 66.With continued reference to FIGS.", "2 and 3, septum actuator 90 further comprises an actuator retention tab 98.In some instances, retention tab 98 comprises an annular protrusion on the outer surface of body 96.In other embodiments, retention tab 98 comprises an annular ring that is fitted onto the outer surface of body 96.Further still, in some embodiments retention tab 98 comprises one or more protrusions having an effective diameter smaller than pathway 46 and larger than proximal opening 42.Thus, retention tab 98 may comprise various structural configurations.", "Retention tab 98 is located on body 96 so as to be positioned within pathway 46 of valve 40.Retention tab 98 comprises an outer diameter that is greater than the outer diameter of body 96 and less than an inner diameter of pathway 46, thereby permitting retention tab 98 to slide freely within pathway 46 of valve 40.Further, the outer diameter of retention tab 98 is greater than a minimum diameter of proximal opening 42.As such, proximal opening 42 comprises a retention ring 48 that prevents retention tab 98 from bypassing proximal opening 42 in proximal direction 102.Thus, retention tab 98 and retention ring 48 prevent removal of septum actuator 90 through opening 28 of catheter adapter 20.In some embodiments, retention tab 98 is positioned on septum actuator body 96 at a distance from base 92, such that base 92 contacts a proximal surface of retention ring 48 when tip 94 is advanced through slit 66 to a desired depth.", "For example, in some instances it may be desirable to prevent over-insertion of tip 94 through slit 66.Over-insertion may be understood to describe a penetration depth of tip 94 into slit 66 where septum 60 is incapable of backing tip 94 out of slit 66 when secondary infusion device 50 is removed from opening 28.Over-insertion of tip 94 into slit 66 may thus prevent slit 66 from reforming a fluid-tight seal.", "Accordingly, in some embodiments, contact between base 92 and a proximal surface of retention ring 48 prevents additional advancement of tip 94 in distal direction 100, thereby preventing over-insertion.", "Similarly, retention tab 98 is positioned on septum actuator body 96 at a distance from base 92, such that tip 94 of septum actuator 90 is permitted to penetrate slit 66 of septum 60 to a minimum insertion depth.", "Minimum insertion depth may be understood to describe a penetration depth of tip 94 into slit 66 where the surface area of the opening provided in slit 66 is greater than or equal to the surface area of the opening of tip 94.As such, the minimum insertion depth through slit 66 provides an opening or fluid pathway through septum 60 that does not impede or interfere with the flow of fluid passing through septum actuator 90.Thus, the position of retention ring 98 relative to the positions of base 92 and tip 94 ensure proper insertion depth of tip 94 through slit 66 of septum 60.Referring now to FIGS.", "4A and 4B, retention ring 48 of valve 40 generally comprises an inner diameter that is greater than the outer diameter of septum actuator 90.As such, septum actuator 90 may freely slide proximally and distally though retention ring 48.In some instances, retention ring 48 comprises a continuous annular surface that approximates the outer surface of septum actuator 90.A small gap 47 is provided between septum actuator 90 and valve 40, thereby permitting free unhindered movement of septum actuator 90 through retention ring 48, as shown in FIG.", "4A.", "In some instances, gap 47 limits the rate at which fluid and/or air is able to bypass retention ring 48.For example, in some instances gap 47 comprises a surface area sufficient to permit passage of air and fluid at a desire flow rate.", "In other embodiments, gap 47 comprises a surface area sufficient to permit passage of air, yet prevent passage of a fluid.", "Further, in at least one embodiment gap 47 comprises a surface area sufficient to prevent passage of air and fluid.", "Thus, gap 47 may be configured to control oe prevent flashback of blood and other fluid through catheter adapter 20.In other embodiments, retention ring 48 comprises a plurality of vents 49 arranged in an annular pattern around proximal opening 42.Vents 49 may comprise any surface area as may be desired to affect the flow of fluid and/or air through catheter adapter 20.For example, in some embodiments vents 49 each comprise a surface area sufficient to permit passage of fluid and air at a desired rate.", "In other embodiments, vents 49 comprise a surface area sufficient to permit passage of air at a desired rate, yet prevent passage of a fluid.", "Further still, in some embodiments vents 49 comprise a surface area that prevents passage of air and fluid.", "In some instances, plurality of vents 49 reduces the stiffness or rigidity of valve 40.As such, valve 40 may more easily be deformed when fluid is injected into side port 30.Thus, in some instances the number and size of vents 49 is selected to achieve a desired stiffness or rigidity for valve 40.Referring now to FIG.", "5, a cross-section side view of a ported catheter device 10 undergoing injection of a fluid 110 is shown.", "Valve 40 generally comprises a flexible polymer tube that may be readily deformed by a fluid 110 that is injected into side port 30 via a secondary infusion device 50.In some instances, retention ring 48 and retention tab 98 are positioned between proximal opening 28 and side port 30.As such, the distal end or opening 48 of valve 40 is deformed and partially collapses as fluid 110 is injected into side port 30.Fluid 110 passes between the outer surface of valve 40 and the inner surface of lumen 26 in distal direction 100 toward blood control septum 60.In some instances, fluid 110 passes between the outer surface of valve 40 and the inner surface of lumen 26 in a proximal direction towards retention ring 48.In some instances, pressure buildup in proximal fluid chamber due to fluid 110 causes slit 66 of septum 60 to partially open, thereby permitting fluid 110 to bypass septum 60 and flow into distal fluid chamber 80.In other instances, fluid 110 remains within proximal fluid chamber 70 until septum actuator 90 is advanced through slit 66to provide a pathway through septum 60.In other embodiments, retention ring 48 is positioned proximate to the middle of valve 40 and at a position that is between side port 30 and blood control valve 60, as shown in FIG.", "6.Retention tab 98 is positioned distally to retention ring 48 and at a position that is between retention ring 48 and blood control valve 60.Proximal opening 42 remains positioned on the proximal end of valve 40 and at a position that is between side port 30 and proximal opening 28.Thus, the distance between base 92 and proximal opening 42 prevents over-insertion, while ensuring a minimum insertion depth of tip 94 through slit 66, as discussed above.", "The distal positions of retention ring 48 and retention tab 98 provide rigidity to the portion of valve 40 located between side port 30 and septum 60.As such, the proximal end or opening 42 of valve 40 is deformed and partially collapses as fluid 110 is injected into side port 30, as shown in FIG.", "7.Fluid 110 passes between the outer surface of valve 40 and inner surface of lumen 26 in proximal direction 102 towards proximal opening 28.Upon removal of secondary infusion device 50 from side port 30, the resilient nature of valve 40 restores the fluid tight seal between valve 40 and side port 30, thereby preventing fluid 110 from exiting catheter adapter 20 via side port 30.For this configuration, fluid 110 is generally injected via side port 30 when a secondary infusion device 50 is coupled to proximal opening 28.Thus, fluid 110 may flow through a vent 91 of septum actuator 90, or through proximal opening 42 and into distal fluid chamber 80 via an opening provided through septum 60 by septum actuator 90.Some embodiments of the present invention further comprise an antimicrobial agent that is applied to one or more surfaces of the infusion therapy device 10 as an antimicrobial coating.", "The antimicrobial agent may comprise any material or combination of materials that are compatible for use on an intravenous device.", "Non-limiting examples of suitable antimicrobial agents include chlorhexidine diacetate, chlorhexidine gluconate, alexidine, silver sulfadiazine, silver acetate, silver citrate hydrate, cetrimide, cetyl pyridium chloride, benzalkonium chloride, o-phthalaldehyde, and silver element.", "The antimicrobial agent is applied to one or more surfaces of the infusion therapy device 10 in a coating matrix that permits the antimicrobial agent to be eluted from the matrix when exposed to a fluid within the catheter adapter.", "Thus, the eluted antimicrobial agent provides a zone of inhibition around the coating surface or component of the infusion therapy device 10.For example, in some instances the retaining tab 98 is coated with an antimicrobial coating matrix comprising an antimicrobial agent that is capable of eluting out of the coating matrix when the coating matrix is exposed to a fluid.", "Thus, the antimicrobial agent provides a zone of inhibition around the retention tab.", "Further, the antimicrobial agent provides antimicrobial properties to the fluid that bypasses the retention tab as it moves through the catheter adapter.", "Thus, the antimicrobial coating matrix may provide a zone of inhibition to the fluid and other surfaces of the infusion therapy device 10 that are downstream from the coated component.", "One having skill in the art will appreciate that the coating matrix and eluting antimicrobial agent may be applied to one or more surfaces of the infusion therapy device 10.For example, in some embodiments one or more of the following components or surfaces of the infusion therapy device 10 is coated with a coating matrix comprising an eluting antimicrobial agent: lumen 26, retention tab 98, septum actuator 90, blood control septum 60, proximal fluid chamber 70, distal fluid chamber 80, valve 40, and side port 30.In other embodiments, a surface or component of infusion therapy device 10 that is positioned in a fluid pathway of the device is coated with an antimicrobial coating and agent, as described herein.", "Some embodiments of the present invention further comprise one or more methods for manufacturing a ported catheter assembly according to the teachings of the instant invention.", "For example, in at least one embodiment a method of manufacturing is provided comprising the following steps: 1) providing a catheter adapter having a proximal end, a distal end and a lumen extending therebetween; 2) placing a side port on a sidewall of the catheter adapter and forming a pathway through the sidewall of the catheter adapter and in communication with the lumen: 3) disposing a blood control septum within the lumen and dividing the lumen into a proximal chamber and a distal chamber; 4) disposing a septum actuator within the proximal chamber of the lumen, the septum actuator having a base, a tip and a body extending therebetween, the tip being positioned proximate to the blood control septum and the base being positioned proximate to the proximal end of the catheter adapter, the septum actuator further comprising an outer diameter; 5) positioning an actuator retention tab on an outer surface of the body, the actuator retention tab having an outer diameter; and 6) disposing a valve within the lumen and forming a seal between the lumen and the pathway of the side port, the valve having a retention ring comprising an inner diameter that is greater than the outer diameter of the septum actuator and less than the outer diameter of the actuator retention tab, wherein the actuator retention tab is positioned on the outer surface of the body between the blood control septum and the actuator retention ring.", "The method may further comprise a step for applying an antimicrobial coating to at least one of the lumen 26 of the catheter adapter 20, the valve 40, the septum actuator 90 and the retention clip 98 wherein the antimicrobial coating comprises an eluting antimicrobial coating whereby the eluting antimicrobial coating provides a zone of inhibition within a fluid within the lumen of the catheter adapter.", "In some instances, a further step is provided for providing a plurality of vents within the actuator retention ring.", "The ported catheter may alternatively be assembled by first inserting the valve into the lumen, and then inserting the actuator, wherein the retention tabs of the actuator snap past the retention ring of the valve.", "The valve material is resilient and therefore easily deforms to allow the actuator retention tabs to pass, thereafter resuming its original conformation.", "The present invention may be embodied in other specific forms without departing from its structures, methods, or other essential characteristics as broadly described herein and claimed hereinafter.", "The described embodiments are to be considered in all respects only as illustrative, and not restrictive.", "The scope of the invention is, therefore, indicated by the appended claims, rather than by the foregoing description.", "All changes that come within the meaning and range of equivalency of the claims are to be embraced within their scope." ] ]
Patent_15872602
[ [ "METHODS AND APPARATUS FOR DISTRIBUTED GAMING OVER A MOBILE DEVICE", "Some embodiments of the invention provide a method and system for detecting unusual performance in a game.", "The game has a participant.", "The method calculates for the participant, a performance metric.", "The method compares the performance metric to a threshold value.", "Based on the comparison, the method optionally connects to a server.", "In some embodiments, the connection is for uploading a set of data from the participant to the server.", "The server, of some embodiments, broadcasts to the participant.", "The broadcast is a one-way transmission.", "In some embodiments, the broadcast includes a distribution based on a set of sample participants.", "In these embodiments, the set of sample participants comprises a representative sample of all the participants in the game.", "The threshold value, of some embodiments, is based on the broadcast and in some embodiments, the broadcast includes a histogram.", "The connecting occurs, in some embodiments, when the performance metric exceeds the threshold value.", "The connection, for some embodiments, includes a two-way connection.", "In some embodiments, the method also tracks for the participant, a participant improvement factor.", "The participant improvement factor is based on an average performance level for the participant.", "The method stores the participant improvement factor.", "The threshold value, in some of these embodiments, is based on the participant improvement factor.", "The method of some embodiments tracks for the game, a game improvement factor.", "The game improvement factor is based on an average performance level for several participants in the game.", "The method stores the game improvement factor.", "The threshold value, in some of these embodiments, is based on the game improvement factor.", "In some embodiments, the method examines the uploaded data for particular characteristics.", "In some embodiments, the particular characteristics indicate the likelihood of cheating activity." ], [ "1.A method of detecting unusual performance in a game, the game having a plurality of persons who participate in the game, each on a client device, the method comprising: selecting a sampling group of persons participating in the game, the sampling group comprising a subset of all persons participating in the game; receiving responses to game elements of the game from client devices of the sampling group to the server; sending from a server to each client device participating in the game, a threshold value determined from the responses received from the sampling group; calculating for each person participating in the game a performance metric; comparing the performance metric to the threshold value thereby forming a comparison; and based on the comparison, for each person participating in the game not in the sampling group, optionally forming a connection to the server for uploading a set of data from the person's client device to the server.", "2.", "(canceled) 3.The method of claim 1, further comprising determining a distribution of results from the responses received from the sampling group, wherein the distribution of results are displayed utilizing a format including one or more of a histogram, percentile and numerical ranking.", "4.", "(canceled) 5.", "(canceled) 6.The method of claim 3, wherein the threshold value is based on the distribution.", "7.The method of claim 1, wherein the connection to the server for persons not in the sampling group is only formed when the performance metric exceeds the threshold value.", "8.The method of claim 1, wherein the connection to the server for persons not in the sampling group comprises a two-way connection.", "9.The method of claim 1, further comprising: tracking at the client device for the person a participant improvement factor, wherein the participant improvement factor is based on an average performance level for the person; and storing the participant improvement factor; wherein the threshold value is based on the participant improvement factor.", "10.The method of claim 1, further comprising: tracking at the server, for the game a game improvement factor, wherein the game improvement factor is based on an average performance level for the sampling group; and storing the game improvement factor; wherein the threshold value is based on the game improvement factor.", "11.The method of claim 1, wherein the server logs activity for the person.", "12.The method of claim 1, further comprising examining the uploaded set of data for a set of particular characteristics.", "13.The method of claim 12, wherein the particular characteristics comprise: an indication that a client device used by the person to upload the data has been accessed abnormally; or an indication that the uploaded data has been altered; or performance data of the person that shows substantial unusual improvement over a history of performance for the participant person; or performance data of the person that shows unusual improvement over a history of performance for a particular set of games, wherein the game is in the particular set of games.", "14.The method of claim 1, wherein the connection is formed over a mobile device network.", "15-22.", "(canceled) 23.A method of detecting unusual performance in a game, the game having a plurality of persons who participate in the game, each on a client device, the method comprising: receiving via the client device a set of data comprising game elements and a threshold value for the game; selecting a sampling group of persons participating in the game, the sampling group comprising a subset of all persons participating in the game; receiving responses to the game elements from the client devices of the sampling group; utilizing the responses received from the sampling group at a server during the game to determine the threshold value for the game; and based on the threshold value for the game, optionally establishing a two-way connection with the server and one or more client devices outside of the sampling group.", "24.", "(canceled) 25.The method of claim 23, wherein establishing the two-way connection further comprises switching the one-way connection to the two-way connection.", "26.The method of claim 25, wherein the switching is performed for a single mobile device.", "27.The method of claim 23, wherein the two-way connection is formed over a mobile device network.", "28.The method of claim 23, wherein the set of data comprises one or more of a histogram, percentile and numerical ranking.", "29.The method of claim 23, further comprising examining the mobile device.", "30.The method of claim 29, wherein examining the mobile device further comprises: determining whether the mobile device has been accessed abnormally, or determining whether data stored by the mobile device has been altered; or determining whether the performance metric comprises an anomaly, wherein the anomaly indicates a likelihood of an unfair game.", "31-37.", "(canceled) 38.A server for conducting a game for a plurality of persons who participate in the game, each on a client device, and for detecting unusual performance in the game among the persons participating in the game by sending game elements and a threshold value, wherein the threshold value is determined based on responses received from a subset of client devices to each client device participating in the game and forming a connection between the server and the subset of the client devices to receive responses to the game elements from the subset of client devices, determining from the received responses the threshold value, and based on the threshold value, optionally receiving from the client devices of persons not in the subset, a set of data.", "39.The server of claim 38, wherein the set of data comprises one or more of a histogram, percentile and numerical ranking.", "40.The server of claim 38, wherein the set of data is only received from the client devices of persons not in the subset when a performance metric of the person participating on the client device exceeds the threshold value.", "41.The method of claim 1 wherein the game comprises a web-connected game.", "42.The method of claim 23 wherein the game comprises a web-connected game.", "43.The method of claim 38 wherein the game comprises a web-connected game.", "44.The method of claim 1, further comprising sending an acknowledgment by the server to the responses which is received by the client device in less than 500 milliseconds.", "45.The method of claim 1, wherein the set of data comprises a percentile standing based on score.", "46.The method of claim 23, wherein the set of data comprises a percentile standing based on score.", "47.The server of claim 38, wherein the set of data comprises a percentile standing based on score.", "48.The method of claim 1 wherein the game is based on a live event.", "49.The method of claim 48 wherein the live event is viewed in person by a person physically attending a location corresponding to the live event.", "50.The method of claim 48 wherein information related to the live event is received from a physical location corresponding to the live event.", "51.The method of claim 1 further comprising implementing one or more lockouts to prevent input.", "52.The method of claim 51 wherein the one or more lockouts occur immediately before competitors in the contests of skill or chance are able to see relevant live game action unfold.", "53.The method of claim 51 wherein the one or more lockouts occur immediately before a scoring chance in the one or more events.", "54.The method of claim 51 wherein the one or more lockouts involve an in-progress play, not during a stoppage, and preventing submitting the response before a critical element of the in-progress play unfolds.", "55.The method of claim 51 wherein the one or more lockouts apply for a limited amount of time.", "56.The method of claim 51 wherein the one or more lockouts apply for an action lasting a limited amount of time.", "57.The method of claim 23 wherein the game is based on a live event.", "58.The method of claim 57 wherein the live event is viewed in person by a person physically attending a location corresponding to the live event.", "59.The method of claim 57 wherein information related to the live event is received from a physical location corresponding to the live event.", "60.The method of claim 23 further comprising implementing one or more lockouts to prevent input.", "61.The method of claim 60 wherein the one or more lockouts occur immediately before competitors in the contests of skill or chance are able to see relevant live game action unfold.", "62.The method of claim 60 wherein the one or more lockouts occur immediately before a scoring chance in the one or more events.", "63.The method of claim 60 wherein the one or more lockouts involve an in-progress play, not during a stoppage, and preventing submitting the response before a critical element of the in-progress play unfolds.", "64.The method of claim 60 wherein the one or more lockouts apply for a limited amount of time.", "65.The method of claim 60 wherein the one or more lockouts apply for an action lasting a limited amount of time.", "66.The server of claim 38 wherein the game is based on a live event.", "67.The server of claim 66 wherein the live event is viewed in person by a person physically attending a location corresponding to the live event.", "68.The server of claim 66 wherein information related to the live event is received from a physical location corresponding to the live event.", "69.The server of claim 38 wherein the server implements one or more lockouts to prevent input.", "70.The server of claim 69 wherein the one or more lockouts occur immediately before competitors in the contests of skill or chance are able to see relevant live game action unfold.", "71.The server of claim 69 wherein the one or more lockouts occur immediately before a scoring chance in the one or more events.", "72.The server of claim 69 wherein the one or more lockouts involve an in-progress play, not during a stoppage, and preventing submitting the response before a critical element of the in-progress play unfolds.", "73.The server of claim 69 wherein the one or more lockouts apply for a limited amount of time.", "74.The server of claim 69 wherein the one or more lockouts apply for an action lasting a limited amount of time." ], [ "<SOH> BACKGROUND <EOH>Participants of distributed gaming have experienced areas of expansion in recent years.", "These participants are enabled to play new games and play existing games in novel ways.", "For example, games today are often played by several participants simultaneously over remote networks.", "Distributed gaming already takes a variety of forms including Internet and/or online games, as well as simple participation events, such as audience polling.", "Existing distributed games already pose issues in game management and control.", "However, several of the complex issues with distributed games have only become more difficult with the expansion into new areas and ways of gaming.", "One issue involves communication with the participants.", "Another issue is the ability to scale for large numbers of participants.", "These two issues make the fundamental task of keeping all the participants updated, into a significant challenge.", "One approach to address these issues is one-way broadcast updating.", "However, this broadcast or multicast approach presents significant security challenges.", "Games of skill and chance have an intrinsic excitement and entertainment value.", "Any game is greatly enhanced by a participant's ability to know how their performance compares in relation to other participants and/or to historical performance for the game throughout the contest.", "However, competition will naturally create incentives to enhance performance in a manner outside the rules of the game, i.e., to cheat.", "Some games provide a lucrative prize based on performance, which creates even greater incentives to break the rules of the game.", "Network based games over the Internet, television, radio, or other complex technology utilizing a one-way multicast or broadcast system create more complicated issues in detection and prevention of cheating.", "Unlike a server controlled contest, there are a variety of ways unobserved competitive participants are able to unfairly manipulate a game that has such a broadcast architecture." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>A system and method are provided for updating game participants.", "The method selects a subset of sampling participants from the set of all participants of a game.", "In some embodiments, the selection occurs prior to the start of the game.", "The method of some embodiments establishes a two-way connection between a server and each of the sampling participants.", "For some embodiments, the two-way connection is realtime.", "The method continuously maintains the two-way connection throughout the game.", "During each discrete game period, for example, each play of a football game, the method receives from a sampling participant, data for the sampling participant's current game period performance.", "Based on the received data, the method determines the performance for the game period and broadcasts this information to a participant.", "In some embodiments, the participant is a non-sampling participant.", "A non-sampling participant is a participant who was not selected for the set of sampling participants.", "In some embodiments, the non-sampling participant determines a standing relative to the other participants in the game event.", "Some embodiments display the determined standing.", "Some embodiments calculate a statistically accurate histogram from the sampling data to represent all the participants.", "In these embodiments, the participant's score is compared to the histogram to determine the standing.", "Some embodiments of the invention provide a method and system for detecting unusual performance in a game.", "The game has a participant.", "The method calculates for the participant, a performance metric.", "The method compares the performance metric to a threshold value.", "Based on the comparison, if an unusually high score or other anomaly is detected, the method optionally connects the participant to a server.", "In some embodiments, the connection is for uploading a set of data from the participant to the server.", "The server, of some embodiments, broadcasts to the participant.", "The broadcast is a one-way transmission.", "In some embodiments, the broadcast includes a distribution based on a set of sample participants.", "In these embodiments, the set of sample participants comprises a representative sample of all the participants in the game.", "The threshold value, of some embodiments, is based on the broadcast and in some embodiments, the broadcast includes a histogram.", "The connecting occurs, in some embodiments, when the performance metric exceeds the threshold value.", "The connection, for some embodiments, includes a two-way connection.", "In some embodiments, the method also tracks for the participant, a participant improvement factor.", "The participant improvement factor is based on an average performance level for the participant.", "The method stores the participant improvement factor.", "In some embodiments, the server stores the participant improvement factor, while in other embodiments, the participant's mobile device stores the improvement factor.", "The threshold value, in some of these embodiments, is based on the participant improvement factor.", "The method of some embodiments tracks for the game, a game improvement factor.", "The game improvement factor is based on an average performance level for several participants in the game.", "The method stores the game improvement factor.", "The threshold value, in some of these embodiments, is based on the game improvement factor.", "In some embodiments, the method examines the uploaded data for particular characteristics.", "In some embodiments, the particular characteristics indicate the likelihood of cheating activity." ], [ "RELATED APPLICATIONS This patent application claims priority under 35 U.S.C.", "§ 119(e) of the co-pending, co-owned U.S.", "Provisional Patent Application No.", "60/588,273, filed Jul.", "14, 2004, entitled “A METHODOLOGY FOR PROVIDING ALL CONTESTANTS IN GAMES OF SKILL PLAYABLE ON CELL PHONES WITH THEIR CURRENT STANDING WHILE RECEIVING GAME CONTROL INFORMATION ONE-WAY VIA A ‘BROADCAST’ TRANSMISSION,” which is hereby incorporated by reference.", "This patent application claims priority under 35 U.S.C.", "§ 119(e) of the co-pending, co-owned U.S.", "Provisional Patent Application No.", "60/583,739, filed Jun.", "28, 2004, entitled “A METHODOLOGY FOR DETECTING CHEATING DURING A REAL TIME CONTEST OF SKILL UTILIZING A CELL PHONE IN CONNECTION WITH A LIVE TELEVISION PROGRAM,” which is hereby incorporated by reference.", "This patent application is concurrently filed with U.S. patent application Ser.", "No.", "_______, entitled METHODS AND APPARATUS FOR DISTRIBUTED GAMING OVER A MOBILE DEVICE, which is hereby incorporated by reference.", "FIELD OF THE INVENTION The present invention relates to the field of distributed gaming.", "More particularly, the present invention relates to the field of distributed gaming utilizing a mobile device.", "BACKGROUND Participants of distributed gaming have experienced areas of expansion in recent years.", "These participants are enabled to play new games and play existing games in novel ways.", "For example, games today are often played by several participants simultaneously over remote networks.", "Distributed gaming already takes a variety of forms including Internet and/or online games, as well as simple participation events, such as audience polling.", "Existing distributed games already pose issues in game management and control.", "However, several of the complex issues with distributed games have only become more difficult with the expansion into new areas and ways of gaming.", "One issue involves communication with the participants.", "Another issue is the ability to scale for large numbers of participants.", "These two issues make the fundamental task of keeping all the participants updated, into a significant challenge.", "One approach to address these issues is one-way broadcast updating.", "However, this broadcast or multicast approach presents significant security challenges.", "Games of skill and chance have an intrinsic excitement and entertainment value.", "Any game is greatly enhanced by a participant's ability to know how their performance compares in relation to other participants and/or to historical performance for the game throughout the contest.", "However, competition will naturally create incentives to enhance performance in a manner outside the rules of the game, i.e., to cheat.", "Some games provide a lucrative prize based on performance, which creates even greater incentives to break the rules of the game.", "Network based games over the Internet, television, radio, or other complex technology utilizing a one-way multicast or broadcast system create more complicated issues in detection and prevention of cheating.", "Unlike a server controlled contest, there are a variety of ways unobserved competitive participants are able to unfairly manipulate a game that has such a broadcast architecture.", "The State of the Art There have been various attempts to address some of the issues raised above.", "Some of these attempts are mentioned below.", "U.S. Pat.", "No.", "5,013,038, filed Dec. 8, 1989, and U.S. Pat.", "No.", "5,120,076, filed Apr.", "25, 1991, both to Luxemberg, et al., (the Luxemberg patents) are directed to reducing the number of telephone calls to the game server only after the conclusion of a game.", "The Luxemberg '076 patent in particular, directs all but a sampling of players to delay sending their scores to the central server in a multicast request after the conclusion of the game.", "The central server compiles the results of the sampling and broadcasts the sampling results to all the participants of the game.", "Each participant then determines the participant's own chance of winning based on the sampling results taken at the conclusion of the game.", "Only those participants whose performance is high enough in comparison to the sampling results are released to send their results to the server for scoring.", "Thus, in the Luxemberg '076 patent, the number of messages over a landline telephone call to the game server is reduced to the number of participants in the sample.", "The game server determines the winners at the conclusion of the contest based on the uploaded scores from only the participants who have a chance of winning and who have thus uploaded their scores to the server.", "The Luxemberg patents ('038 and '076) also provide for the collection of market information surveys after conclusion of the game.", "However, the Luxemberg patents suffer from lack of real-time capability as participants must wait for each of the sample participants to dial-in their results over telephone lines.", "The Luxemberg patents also suffer from the inability to specifically select and connect with a statistical sample.", "U.S. Pat.", "No.", "5,083,800, filed Jun.", "7, 1990, to Lockton describes using a one-way FM subcarrier (SCA) channel to broadcast from the server to game participants, while the game participants upload through telephone lines.", "U.S. Pat.", "No.", "5,479,492, filed Dec. 1, 1993, to Hofstee, et al., describes voting in response to a television or radio broadcast by using a ballot box attached to a telephone line that introduces a time delay.", "U.S. Pat.", "No.", "5,643,088, filed May 31, 1995, to Vaughn, et al., describes interleaved interactive advertising in the broadcasts.", "U.S. Pat.", "No.", "5,813,913, filed May 30, 1995, to Berner, et al.", "(Berner) describes a system where players are grouped according to skill level for competition and comparison within a particular skill level.", "In Berner, the central computer system sends a lockout signal at the conclusion of each game where only players of the particular skill level update their performance through telephone lines.", "However, none of these attempts provide for real time updating, to large numbers of participants, information regarding the standings of a game, particularly over new types of networks.", "One such network that shows promise is a network for mobile devices such as a cellular network.", "Moreover, none of the prior techniques address the issues particular to mobile device gaming such as the unfair manipulation of technology.", "SUMMARY OF THE INVENTION A system and method are provided for updating game participants.", "The method selects a subset of sampling participants from the set of all participants of a game.", "In some embodiments, the selection occurs prior to the start of the game.", "The method of some embodiments establishes a two-way connection between a server and each of the sampling participants.", "For some embodiments, the two-way connection is realtime.", "The method continuously maintains the two-way connection throughout the game.", "During each discrete game period, for example, each play of a football game, the method receives from a sampling participant, data for the sampling participant's current game period performance.", "Based on the received data, the method determines the performance for the game period and broadcasts this information to a participant.", "In some embodiments, the participant is a non-sampling participant.", "A non-sampling participant is a participant who was not selected for the set of sampling participants.", "In some embodiments, the non-sampling participant determines a standing relative to the other participants in the game event.", "Some embodiments display the determined standing.", "Some embodiments calculate a statistically accurate histogram from the sampling data to represent all the participants.", "In these embodiments, the participant's score is compared to the histogram to determine the standing.", "Some embodiments of the invention provide a method and system for detecting unusual performance in a game.", "The game has a participant.", "The method calculates for the participant, a performance metric.", "The method compares the performance metric to a threshold value.", "Based on the comparison, if an unusually high score or other anomaly is detected, the method optionally connects the participant to a server.", "In some embodiments, the connection is for uploading a set of data from the participant to the server.", "The server, of some embodiments, broadcasts to the participant.", "The broadcast is a one-way transmission.", "In some embodiments, the broadcast includes a distribution based on a set of sample participants.", "In these embodiments, the set of sample participants comprises a representative sample of all the participants in the game.", "The threshold value, of some embodiments, is based on the broadcast and in some embodiments, the broadcast includes a histogram.", "The connecting occurs, in some embodiments, when the performance metric exceeds the threshold value.", "The connection, for some embodiments, includes a two-way connection.", "In some embodiments, the method also tracks for the participant, a participant improvement factor.", "The participant improvement factor is based on an average performance level for the participant.", "The method stores the participant improvement factor.", "In some embodiments, the server stores the participant improvement factor, while in other embodiments, the participant's mobile device stores the improvement factor.", "The threshold value, in some of these embodiments, is based on the participant improvement factor.", "The method of some embodiments tracks for the game, a game improvement factor.", "The game improvement factor is based on an average performance level for several participants in the game.", "The method stores the game improvement factor.", "The threshold value, in some of these embodiments, is based on the game improvement factor.", "In some embodiments, the method examines the uploaded data for particular characteristics.", "In some embodiments, the particular characteristics indicate the likelihood of cheating activity.", "BRIEF DESCRIPTION OF THE DRAWINGS The novel features of the invention are set forth in the appended claims.", "However, for purpose of explanation, several embodiments of the invention are set forth in the following figures.", "FIG.", "1 illustrates a mixed topology for a network game.", "FIG.", "2 illustrates a process flow for getting a schedule of events on a mobile device for a network game.", "FIG.", "3 illustrates a process flow for play in conjunction with a synchronized live event on a mobile device in a network game.", "FIG.", "4 illustrates a process flow for a server sending a list of schedule of events for a network game.", "FIG.", "5 illustrates a process flow for a server setting up a network game.", "FIG.", "6 illustrates a process flow for a server officiating a network game.", "FIG.", "7 illustrates the system implemented by some embodiments.", "DETAILED DESCRIPTION OF THE INVENTION In the following description, numerous details are set forth for purpose of explanation.", "However, one of ordinary skill in the art will realize that the invention may be practiced without the use of these specific details.", "In other instances, well-known structures and devices are shown in block diagram form in order not to obscure the description of the invention with unnecessary detail.", "Section I below describes notification of participants of their performance.", "Section II describes the detection of unusual activity for a participant that could constitute cheating.", "Section III describes the network cluster system implemented by some embodiments, and Section IV describes some advantages of the invention.", "With the proliferation of mobile devices, a growing number of mobile device users are able to participate in a distributed online or network game.", "These games might be associated with various popular live and/or televised events.", "Participants of the game typically answer questions utilizing a mobile device as a live contestant at a game show (e.g., Wheel of Fortune®, Jeopardy®, etc.).", "Participants are also able to make simple predictions regarding the outcome of events and even play-by-play decisions for sporting events such as football, baseball, racing, or any of a number of other sporting events.", "The expansion to include participants utilizing mobile devices increases the number of participants in these network games almost limitlessly.", "For instance, the Super Bowl live audience numbers in the tens of thousands of spectators, while the television audience may number in excess of 100,000,000 viewers.", "Many of these viewers have access to an assortment of mobile devices, e.g., most commonly in the form of the ubiquitous cellular telephone.", "For high bandwidth connections, games are typically controlled through a full time (two-way) connection to a game server that can routinely supply information to the participants of the game.", "As is known in the art, two-way network connections provide comparatively reliable and secure service.", "However, forming a two-way connection between the high potential number of participants of a real-time game (e.g., associated with a broadcast event) and a central host server creates challenges because of the low latency demands of such a game played in realtime.", "Moreover, two-way networks pose scalability issues and become impractical for massive numbers of participants and for games over low bandwidth connections such as some mobile networks.", "Two-way communication generates a variable cost for each additional competing participant.", "Ultimately, the implementation of such a two-way system could be prohibitively expensive because of the vast communication demands of continuously updating potentially millions of contestants of the status of their ongoing, changing, and fast paced predictions.", "This burden on the game server is significant because many games require acknowledgment by the server of the continuously changing predictions, which must be displayed on the mobile device in less than 500 milliseconds.", "The same problem also exists in non-television broadcast based games played over mobile devices that require a common start time for all competitors and where there are a large number of potential competitors.", "I.", "Providing Participants with Current Standing while Receiving Game Control Information Via One-Way Broadcast.", "A system and method are provided for updating participants in a game.", "In some embodiments, the method selects a set of sampling participants from the set of all participants of a game.", "In some of these embodiments, the selection occurs prior to the start of the game.", "The method of some embodiments establishes a two-way connection between a server and each of the sampling participants.", "The method continuously maintains the two-way connection throughout the game.", "After each discrete game period, the method receives from a sampling participant, data for the sampling participant's game period performance.", "Based on the received data, the method determines the performance for the game period and broadcasts this information to a participant.", "Some embodiments base the data on a statistically projectable random sample that is representative of all the participants in the game.", "In some embodiments, the broadcast recipient is a non-sampling participant.", "A non-sampling participant is a participant who was not selected for the set of sampling participants.", "In some embodiments, the non-sampling participant, utilizing the projectable data, determines a standing relative to the other participants for the game period.", "As mentioned above, the most cost effective means of controlling a large-scale network game is to use a broadcast server topology to one-way multicast the same information to all participants simultaneously.", "Thus, some embodiments of the invention provide for a mobile device (e.g., cellular phone, PDA, etc.)", "as the receiver in a broadcast receiver topology.", "However, many current mobile devices are capable of operation in both one-way and two-way modes.", "These modes include small message service (SMS), instant messaging (IM) or Internet Relay Chat (IRC), email, voice and/or other data modes over a number of protocols such as transport control protocol (TCP) or universal datagram protocol (UDP).", "Thus, the network game topology of some embodiments may include a mixture of one-way receivers and two-way clients to realize the benefits of both the one-way broadcast and two-way client/server architectures.", "FIG.", "1 illustrates such a mixed topology 100.As shown in FIG.", "1, a server 105 simultaneously broadcasts to several receivers 110-125 that are configured for one-way mode reception, while sending and receiving messages with a two-way mode client 130, through a network 140.In some embodiments, the network 140 includes a cellular network.", "Current mobile device technology allows the use of each mobile device connected to the network 140 to store locally certain game information such as a cumulative score.", "Particularly for the broadcast receivers 110-125, this relieves some burden on the server in storing and managing this data, and on the network 140 in relaying the data.", "As mentioned above, one advantage of the one-way architecture is reducing network and/or server latency by the distribution of data for processing and/or storage at the receiver.", "To implement such a topology, some embodiments employ a setup process that will be described by reference to FIG.", "2.A.", "Participant'S Mobile Device Setup FIG.", "2 illustrates a mobile device setup process 200 for getting a schedule of events on a mobile device for a network game.", "As shown in this figure, the mobile device set up process 200 begins at step 205, where a game participant selects a game application by using the participant's mobile device.", "Then the process 200 transitions to step 210, where the mobile device requests a list of game events associated with the selected game from a server, such as the server 100 represented in FIG.", "1.In some embodiments, the server 100 is a single computer, while in other embodiments the server 100 takes the form of any number of computers in any number of configurations, such as a server farm or cluster.", "Regardless of the configuration, the server typically hosts and officiates the game for these embodiments.", "The server of some embodiments will be described in further detail by reference to FIGS.", "4, 5, and 6.As shown in FIG.", "2, after requesting a list of events at step 210, the mobile device receives a list of game events and displays the list to the participant at step 215.At step 220, the participant selects a game event in which to compete, and sends the selection to the server.", "Typically, the server configures the game event for the requesting mobile device.", "The server configuration of some embodiments includes a determination of whether the mobile device should set up a one-way or two-way connection with the server.", "The configuration process by the server of some embodiments will be described in further detail by reference to FIG.", "5.When the server has configured the game event, the requesting mobile device receives a configuration message from the server at step 225 and the process transitions to step 230.At step 230, the mobile device of some embodiments determines whether the configuration message from the server indicated that the mobile device should set up for one-way broadcast mode.", "If the message at step 225 indicates that the mobile device should operate in broadcast mode, the process 200 transitions to step 235 where the mobile device is configured to receive one-way broadcast transmissions from the server, and then the process 200 concludes.", "Otherwise, the process 200 transitions to step 240 where the mobile device sets up a two-way client/server connection with the server for the selected game event, and the mobile device setup process 200 concludes.", "B.", "Participant's Mobile Device Operation Once the participant has selected the game and the mobile device has prepared the connection with the server.", "The participant may play the game over the mobile device.", "FIG.", "3 illustrates a mobile device operation process 300 for play in conjunction with a synchronized live event.", "The mobile device operation process 300 begins at step 305 where the process 300 determines whether the game is over.", "If the game is over, then the process 300 concludes.", "If the game is not over, then the process 300 transitions to step 310 where the participant makes a prediction regarding some facet of the game being played.", "The participant makes the prediction by using the mobile device that was set up to play the game in accordance with the set up process 200 described above in relation to FIG.", "2.As shown in FIG.", "3, after the participant makes a prediction, the mobile device operation process 300 transitions to step 315 when the mobile device receives a lockout message from the server.", "At step 315, upon receiving the lockout message, the mobile device displays the participant's current prediction, if any, to the participant.", "In some embodiments, at the conclusion of each game period or scoring event, for example a football play or a baseball pitch, the server sends “lock out” signals prohibiting predictions or answers to the questions via a one-way broadcast transmission before the correct answers or facts are revealed.", "The participant's mobile device in these embodiments determines whether the participant's predictions or answers were: (1) entered prior to the receipt of the time stamped lock out message and (2) correct or incorrect.", "In some embodiments, the mobile device computes locally a cumulative score based on whether the participant was correct, as opposed to performing these calculations for each participant on a central server.", "Such a system has the ability to scale to accommodate a potentially large number of participants from a huge audience.", "The lockout message and whether a game is over will be described later by reference to FIG.", "6.After the mobile device receives a lockout message at step 315, the process 300 transitions to step 320 where the mobile device receives the correct answer from the server, compares the received answer to the participant's prediction, and displays the comparison to the participant.", "Then, at step 325, the mobile device receives a set of sampling results from the server.", "Prior to the commencement of the game, the server of some embodiments selects a statistically significant random sample of participants who have registered their intention to play the game.", "The server instructs these sampling participants' mobile devices to establish with the server a two-way connection to be maintained for the duration of the contest or game.", "Some embodiments establish the two-way connection transparently, which occurs with or without the participant's knowledge.", "The server of some embodiments monitors the period-by-period scores of this statistically significant set of sampling participants.", "In some embodiments, the sampling results contain a distribution of the performance of the sampling participants for the last period of the game that was tabulated.", "Some of these embodiments employ a histogram format to represent the sampling results.", "After each discrete period in the contest, the server of some embodiments broadcasts some of the information collected from the sampling participants as well as the correct answers or predictions for each game period.", "In some of these embodiments, the game application software residing in the mobile device will compare the participant's current score to the sampling results.", "For example, a participant who won the maximum number of points possible on their last prediction might be informed they had moved up from the 72nd percentile to the 89th percentile at that point in the game.", "Some embodiments further provide a visual display of the current percentile standing for the participant based upon the comparison of the participant's score to the representative sample.", "For some of these embodiments, the sampling results include a histogram or another graphical representation of the sampling results.", "Generation and transmission of the sampling results will be further described below by reference to FIG.", "6.When the mobile device receives the sampling results at step 325, the process 300 transitions to step 330 where the mobile device compares the participant's performance to the sampling results and displays the comparison to the participant.", "Then, the process 300 transitions to step 335 where the mobile device tabulates and stores the participant's performance for the game.", "This tabulation and storage may include a ranking system.", "Once the mobile device determines the participant's performance, the process 300 transitions to step 340 where the process 300 determines whether the participant has achieved a high degree of performance.", "For some embodiments, a high degree of performance indicates a greater likelihood that the participant will have high enough score(s) to win.", "In these embodiments, the method uploads the participant's performance to the server for comparison against the uploaded results of the other high performers.", "Thus, these embodiments monitor only the subset of high scorers, based on the particular game parameters, to determine the winner(s).", "If the participant has not achieved notable performance, the process 300 concludes.", "Otherwise if the participant has performed well, the process 300 of some embodiments transitions to step 345, where the process 300 determines whether the participant has exceeded one or more performance factors.", "If the participant has not exceeded the performance factor(s) then the process 300 transitions to step 355 where the mobile device uploads the participant's performance information to the server, and the process 300 concludes.", "Otherwise, the participant exceeds the performance factor and the process 300 transitions to step 350 where the mobile device switches to a two-way client/server mode.", "Then the mobile device uploads the participant's performance information to the server at step 355 and the process concludes.", "Some embodiments use the performance determination at step 340 to check whether the participant's performance is high enough to warrant transmission to the server.", "In these embodiments, high performance may indicate whether the participant is likely to win.", "Some embodiments use the performance factor of step 345 in FIG.", "3 to determine whether the participant exhibits unusual performance or activity that might constitute cheating.", "This topic will be further discussed in Section II.", "The description above regarding setup and operation of a mobile device has alluded at various times to interaction with a server.", "The server of some embodiments will now be described in further detail by reference to FIGS.", "4, 5, and 6.C.", "Server Setup As mentioned above, the mixed network topology 100 illustrated in FIG.", "1 employs a server 105 to operate and officiate a game that is provided to a set of heterogeneous mobile devices.", "As discussed above in relation to FIG.", "2, the games begin by a participant selecting a game event through a mobile device, and by the mobile device requesting a list of hosted game events.", "FIG.", "4 illustrates a server hosting process 400 for a server sending a list of schedule of events for a network game.", "As shown in FIG.", "4, the hosting process 400 begins at step 405 where the server receives from a mobile device, a request for a list of events associated with a game.", "Then the process 400 transitions to step 410 where the server looks up events associated with the game in a master list of games and events.", "For instance, for the game of “football” the master list of games and events might include the “Super Bowl” as an event.", "This master list is maintained by some embodiments on a data storage.", "At step 415, the server returns the list of events to the requesting mobile device and waits for the mobile device to make a selection.", "At step 420, the server receives from the requesting mobile device a selection for a game event and then the hosting process 400 concludes.", "Once the server of some embodiments receives the selection of a game event from a requesting mobile device, the server performs certain setup operations for the requested game event.", "In some embodiments, the server logs the mobile device and/or the participant operating the mobile device to one or more data storages maintained by the server.", "The server of some embodiments may request the identification explicitly, while the mobile device of other embodiments will transmit the identification separately, or in conjunction with another message to the server regardless of a specific identification request.", "FIG.", "5 illustrates a process 500 for a server setting up a network game.", "The server setup process 500 begins at step 505 when the server receives identification from the mobile device.", "As mentioned, this identification can represent a participant and/or the participant's mobile device.", "At step, 510 the server uses the received identifier to look up the performance history associated to the received identifier.", "The server of some embodiments may use a data storage for the lookup.", "Then, the process 500 transitions to step 515, where the process 500 determines based on the participant's performance history, whether the participant is likely to win.", "The determination of some embodiments may be an approximation of performance for the selected game event, particularly if little or no performance history has been logged to the data storages for the particular participant.", "If at step 515, the participant is likely to win, then the server setup process 500 transitions to step 530 where the server sends a message to set the mobile device in a two-way client/server communications mode.", "In the two-way mode, the server monitors closely the participant's performance for the game event.", "In these embodiments, the server is constantly updated with only the most relevant data from a subset of participants who are likely to win.", "Otherwise, if at step 515, the participant is not likely to win, then the process 500 transitions to step 520, where the process 500 determines whether there is a proper statistical sampling of scores.", "In some embodiments, the server setup process 500 determines whether the number of two-way (real-time) connections to the server is statistically significant, i.e., is sufficient to provide a reasonably reliable representation of the population of all participants in the game event.", "If at step 520, there is not a proper statistical sampling (e.g., there are not enough two-way connections for statistical significance) then the process 500 transitions to step 530 where the server sends a message to set the mobile device in two-way client/server mode (thus, increasing the number of two-way connections toward statistical significance), and the process 500 concludes.", "Otherwise, the process 500 transitions to step 525 where the server sends a message to set the mobile device in one-way mode to receive broadcasts from the server, and the server setup process 500 concludes.", "As mentioned above, some embodiments pre-select a set of sampling participants for two-way connections at the start of each game.", "D. Server Operation Once the server has set up and sent the mobile device configuration messages for the selected game, the server will then typically conduct and officiate the game.", "FIG.", "6 illustrates a process 600 for a server officiating a network game.", "As shown in this Figure, the server operation process 600 begins at step 605 where the server transmits parameters and other information regarding the game to any mobile devices that have selected participation for the game period.", "For the mixed topology 100 illustrated in FIG.", "1, mobile devices configured for one-way mode will typically receive the game information through broadcast messages from the server, while mobile devices configured for two-way mode will send and receive in a manner that is typical of client/server connections.", "The transmissions and/or broadcasts will continue at step 605 until the conclusion of the game period as determined by the particular game parameters.", "Then the process 600 transitions to step 610 where the server generates and sends a lockout message to notify the participating or subscribed mobile devices that the game period has concluded.", "In some embodiments, the lockout message includes a timestamp.", "After the lockout message, the server generates and sends the correct result for the recently concluded game period at step 15.Then the process 600 transitions to step 620 where the server compiles the available performance data from the two-way client/server mode participants.", "As mentioned above, in some embodiments the two-way mode participants form a representative sample of all participants competing during the particular game period.", "The server operation process 600 of some embodiments generates a graphical representation of the results obtained from the representative sample of participants.", "Some of these embodiments use a histogram format to illustrate the sampling results.", "Once the server operation process 600 compiles the sampling results at step 620, the process 600 transitions to step 625 where the server sends the sampling results to the participants of the game period.", "In particular, the server typically broadcasts the sampling results to the one-way mode participants.", "After broadcasting the sampling results, the process 600 transitions to step 630 where the server receives uploaded results from the high performing one-way mode participants.", "As described above in relation to FIG.", "3, in some embodiments the high performing one-way mode participants determined their status as high performers based on the sampling results received from the server, and only those participants who were likely to win the game event or period upload their results to the server.", "As shown in FIG.", "6, after step 630, the server operation process 600 transitions to step 635 where the process 600 may perform a number of functions.", "For instance, the process 600 of some embodiments determines and/or notifies one or more winners of the current game event or period.", "The process 600 of some embodiments also makes determinations or calculations as to the categories and criteria for winners of the game event and/or period.", "Thus, for each discrete period a participant's score may increment or decrement by the appropriate number of points depending on the game rules.", "Some embodiments calculate a total and/or cumulative score for the particular participant.", "The details of the discrete period and the scoring typically encompasses the underlying facets of the game's subject matter such as, for example, the answer to a televised Jeopardy® question, or the results of a prediction of what play will be called by the quarterback in a televised football game.", "When the server operation process 600 completes the various tasks at step 630, the process 600 transitions to step 640 where the process 600 determines whether the game, the event, and/or the period are over, based on a set of criteria specific to the selected game.", "If the game is not over, then the server operation process 600 returns to step 605, otherwise the process 600 concludes.", "As one of ordinary skill will recognize, the officiating server during an online network game does not monitor a majority of the participants, particularly the one-way broadcast participants.", "In a network environment of heterogeneous mobile devices, this creates opportunities for participants to unfairly modify and report their performance.", "Next, Section II describes the additional measures that some embodiments provide to address these concerns.", "II.", "Detecting Cheating for a Game Played over a Mobile Device As mentioned above, games broadcast to mobile devices pose specific challenges as to data validation and overall game integrity.", "For example, a participant using a mobile device in an online or network game is able to (1) access the mobile device client to probe the microprocessor, and/or the RAM to modify the local data at the client device; (2) “spoof” or emulate another mobile client device or; (3) apply other techniques to enter predictions after the answers are known.", "Thus, a crafty participant is able to create game scores that are not legitimately achieved out of view of the officiating secure server and submit the unfairly achieved performance for scoring against un-enhanced legitimate competitors.", "To cope with this issue, some embodiments provide a method and system for detecting unusual performance in a game.", "The game has a participant.", "In some embodiments, the game is a game of skill, which, as with most games of skill, performance improves with repetitive play, until a participant reaches their general level of skill.", "The method calculates for the participant an average performance level.", "Based on the average performance level, the method tracks for the participant, a participant improvement factor and stores the participant improvement factor.", "The method compares the participant improvement factor to a threshold value.", "As mentioned above, some embodiments make this comparison at step 345, of the process flow 300 illustrated in FIG.", "3.Some embodiments additionally track a game improvement factor (e.g., at step 635 in FIG.", "6).", "In some of these embodiments the game improvement factor includes the average change in performance over time for all participants of the game.", "In some embodiments, any participant whose current game performance is exceeding either the overall game improvement factor, and/or the individual's participant improvement factor, or who is achieving a score at the very highest level of the current online players, will trigger the establishment of a two-way connection with the server for closer two-way monitoring of the participant's activity during the remainder of the game.", "Additionally, participants who approach a level of performance sufficient to win a significant prize, tournament points, or other reward, are also selected by some embodiments for a two-way server connection at various times during their participation of a network game.", "The two-way connection employs the transport control protocol (TCP) in some embodiments, while other embodiments might employ another suitable protocol.", "The server of some embodiments is a “game session server” provided by AirPlay Network, Inc.", "The system implementation of some embodiments will be described further in Section III.", "Once a two-way connection is triggered, the server of some embodiments records data for the ongoing game play of the triggering participant and performs a variety of tests.", "The tests of some embodiments include the recording of each entry by the participant, and examining the time stamp, user input, and other data being received from the participant's mobile device.", "Some embodiments use the recorded data to identify anomalies in the participant's activities.", "The anomalies might include (1) abnormal improvement in results relative to other participants, (2) abnormal improvement in performance based on prior performance for the particular participant, (3) signs that the application software has been altered, (4) anomalies in the utilization of the game control interface, and/or (5) indications through encryption and additional non-obvious data that the final score upload has been altered.", "Some embodiments, when detecting an anomaly, require future game play by the participant suspected of unfair activity to be conducted on a two-way basis with the server for close monitoring.", "For instance, during the game play of these embodiments, every play prediction is stored inside the mobile device and is sent periodically to the game server.", "Moreover, some embodiments store in a database each participant's relative performance for each game in which the participant competes.", "In some embodiments, the participant's relative performance is stored in the form of a percentile standing.", "Some embodiments calculate and store the average performance level and the average incremental improvement in the percentile standing for each participant.", "As participants improve over time with practice and experience, some embodiments continually calculate an average improvement factor for both the game in general, as well as for a specific participant.", "For instance, the average improvement in percentile standing of a specific participant for a particular game might be two percentile points, while the average improvement for a group of participants at a particular skill level game-wide, might be three percentile points.", "Thus, the threshold value used by some embodiments to gauge a participant's performance may vary for each participant, and for each game, and may also vary over time.", "The threshold values of these embodiments are adjusted based on one or more of these or other factors (e.g., the participant and game factors, over time).", "Moreover, some embodiments employ multiple checks against one or more of the threshold values.", "For instance, the participant's improvement may not be that notable based on the participant's history but is unusual for the particular game played.", "In some embodiments, information regarding the average improvement in percentile standing for a participant and/or for the group of participants within a particular skill level for the game is stored to the participant's mobile device by using software that has been loaded into the participant's mobile device memory and/or that has been downloaded with an applications program.", "These embodiments continuously compare each participant's current percentile standing to the stored information that includes the improvement factors previously described.", "For some embodiments, information is updated in realtime.", "This includes updating the sampling distribution representing the game-wide performance through the (realtime) two-way connections, as well as updating the broadcast participants utilizing the one-way connections.", "Also previously mentioned, during play of the game, performance or scoring information may be represented in some embodiments by a histogram format, which may be displayed at various times on the participant's mobile device.", "The histogram of these embodiments may contain the performance of a random sample of selected participants who are continually connected to the server.", "In some embodiments, the mobile device might generate the histogram, while for other embodiments, the histogram is broadcast to all participants by the server.", "The point values to win for each game being played is different and depends upon the following, among other things: the game; the difficulty of the game; and the performance of the players playing the game.", "Thus, the histogram is used to track the scores of a sampling of the players and communicate those scores to all of the players during the game.", "Each mobile device will then be able to determine how the corresponding player is performing in the current game relative to the other players.", "III.", "System As previously mentioned, the server 105 illustrated in FIG.", "1 is implemented in some embodiments by using a more complex system that includes multiple servers and/or multiple server clusters.", "To further illustrate this scalability feature, the server of some embodiments is depicted in FIG.", "7 as a cluster or several clusters of server computers.", "Accordingly, FIG.", "7 illustrates a system 705 implemented by some embodiments that includes a communication layer 710, a master layer 715, data storages 720, and administration tools 725.Further shown in FIG.", "7, one or more mobile devices 110-130 connect to the system 705 through a network 140.As previously mentioned, the network 140 in some embodiments includes a mobile device network such as a cellular network, which employs a variety of communications protocols to transmit data both one-way and two-way between the mobile devices 110-130 and the system 705.In some embodiments, initial messages received by the system 705 are handled by the communication layer 710.In these embodiments, the communication layer 710 might include dedicated servers to handle the communication needs of a large scale hosted network game.", "For instance, the communication layer 710 of some embodiments includes a Connection Cluster, a Game Session Cluster, a Score Cluster, a Broadcast Cluster, and a Web Cluster, all provided by AirPlay Network, Inc.", "In these embodiments, the task of sending and receiving data in the processes of, for example, setting up a game, providing an event list, providing game parameters during a game, and updating scores, is divided among the separate servers and/or clusters.", "Also shown in FIG.", "7, the communications layer 715 is coupled to a master layer 720.In some embodiments, the master layer 720 includes operational support for hosting and officiating the network games.", "In these embodiments, this hosted support might include server applications and functions for scheduling, registration, scoring, and validation.", "The master layer 720 often operates on massive amounts of data, thus each function in these embodiments is typically delegated to a dedicated collection of servers and/or clusters (e.g., a Schedule Cluster, a Registration Cluster, and a Scoring/Validation Cluster, also provided in some embodiments by Airplay Network, Inc.).", "The master layer 720 is further coupled to a set of data storages 720 to enable, for example, look ups into scheduling data such as a master schedule of games and events, user data such as participant and/or mobile device profiles and history, as well as prize data, results, metrics, and reporting data.", "Also shown in FIG.", "7, the data storages 720 and the master layer 715 of some embodiments are coupled to a set of administration tools 725 that allow, for example, data entry and management such as scheduling and customer service functions.", "In these embodiments, the administration tools include user interfaces, terminals, and other appropriate administration means.", "IV.", "Advantages In the embodiments described above, each participant among potentially millions of participants may receive data on a one-way basis that indicates a highly accurate approximation of the participant's percentile standing after each event in real-time throughout the game.", "Some embodiments of the invention enable the server providing game control to utilize a one-way broadcast transmission for all but a small fraction of the participants, which significantly reduces the number of servers required to conduct a massive real time game.", "These embodiments also reduce the communications traffic on the cellular networks.", "These communications and infrastructure costs of operating the game could otherwise be insurmountable.", "In addition to the benefit of providing current standings to all participants, the present invention also dramatically reduces the number of scoring calls both during and at the conclusion of an event, which represents a significant improvement over the art.", "The present invention establishes and maintains an ongoing two-way connection with a sample of participants throughout the game.", "The present invention monitors this sample and makes the information available game-wide in real-time.", "Therefore, the present invention does not require additional time to collect, process, and rebroadcast to the game participants instructions to later establish a two-way connection and upload scores for verification and ranking.", "Further, the present invention permits an almost immediate data collection, verification, and notification process, from only the most relevant group of participants in a game.", "Moreover, the present invention addresses issues of integrity that are critical to a large-scale network game, which particularly may involve a number of mobile devices.", "A sponsor of such a large or network game offering may charge for the service and award prizes to winners.", "As mentioned above, the participation for such events can number potentially in the tens of millions of simultaneous subscribers, particularly by using the multicast mobile or cellular network configuration of some embodiments.", "However, such a game will draw little market response if the sponsor cannot maintain the integrity of the game.", "Issues of cheating may be addressed by employing two-way connections to closely monitor participants, but this quickly becomes impractical for large numbers of participants.", "Also, in some games based on rapidly unfolding events, such as a live telecast of a sporting event, the latency inherent in controlling a client utilizing a two-way connection (e.g., a cellular telephone) to a secure server makes keeping up with the telecast problematic.", "Some embodiments of the present invention incur the high overhead of two-way monitoring for only the set of participants who have a higher risk of cheating and/or have a high risk of winning.", "Such a system dramatically improves the economics of staging the network game and the quality of service for all the subscribed participants.", "While the invention has been described with reference to numerous specific details, one of ordinary skill in the art will recognize that the invention can be embodied in other specific forms without departing from the spirit of the invention.", "Thus, one of ordinary skill in the art will understand that the invention is not to be limited by the foregoing illustrative details, but rather is to be defined by the appended claims." ] ]
Patent_15872608
[ [ "TREATMENT INSTRUMENT", "A treatment instrument includes a first treatment portion including a first member with a first contact surface and a second member with a second contact surface; a movement mechanism to switch between a closed position where the first and second contact surfaces are close to each other and an open position where the first and second contact surfaces are separated each other; and a second treatment portion juxtaposed to the first treatment portion.", "A distal end of the second treatment portion is located at a distal side in the longitudinal axis than a distal end of the first treatment portion on the closed position." ], [ "1.A treatment instrument comprising: a sheath which defines a longitudinal axis with a distal end and a proximal end; a first treatment portion which includes a first member including a first contact surface coming into contact with a living tissue and a second member including a second contact surface facing the first contact surface and coming into contact with the living tissue at a position closer to a proximal side than the first contact surface along the longitudinal axis and which is configured to coagulate the living tissue by applying energy to the living tissue sandwiched between the first contact surface and the second contact surface; a movement mechanism which is configured to move at least one of the first member and the second member along the longitudinal axis and to switch between a closed position where the first contact surface is close to the second contact surface and an open position where the first contact surface is separate from the second contact surface; and a second treatment portion which is fixed to the sheath and juxtaposed to the first treatment portion, wherein a distal end of the second treatment portion is located at a position closer to a distal side along the longitudinal axis than a distal end of the first treatment portion when the first contact surface and the second contact surface are located at the closed position, and the distal end of the second treatment portion is located at the same position as the position of the distal end of the first treatment portion or located closer to the proximal side than the distal end of the first treatment portion when the first contact surface and the second contact surface are located at the open position.", "2.", "(canceled) 3.The treatment instrument of claim 1, wherein the second treatment portion is configured to incise or peel the living tissue by applying energy to the living tissue.", "4.The treatment instrument of claim 1, wherein the movement mechanism includes: a slider which is coupled to the second member and which is movable along the longitudinal axis of the sheath; and an energizing member having one end coupled to the first member and the other end coupled to one of the slider and the second member.", "5.The treatment instrument of claim 4, wherein the energizing member is configured to move the first member and the second member together.", "6.The treatment instrument of claim 5, wherein: the first member includes an engagement portion whose position is defined relative to the sheath when the slider moves from the proximal side to the distal side along the longitudinal axis, and the slider is configured to make the second contact surface of the second member approach the first contact surface of the first member as the slider moves from the proximal side to the distal side along the longitudinal axis against an energizing force of the energizing member while the first member engages with the sheath via the engagement portion.", "7.The treatment instrument of claim 1, wherein the first member of the first treatment portion includes a channel in which the second treatment portion is arranged." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> BRIEF SUMMARY OF THE INVENTION <EOH>According to one aspect of the present invention, a treatment instrument includes: a sheath which defines a longitudinal axis with a distal end and a proximal end; a first treatment portion which includes a first member including a first contact surface coming into contact with a living tissue and a second member including a second contact surface facing the first contact surface and coming into contact with the living tissue at a position closer to a proximal side than the first contact surface along the longitudinal axis and which is configured to coagulate the living tissue by applying energy to the living tissue sandwiched between the first contact surface and the second contact surface; a movement mechanism which is configured to move at least one of the first member and the second member along the longitudinal axis and to switch between a closed position where the first contact surface is close to the second contact surface and an open position where the first contact surface is separate from the second contact surface; and a second treatment portion which is juxtaposed to the first treatment portion, wherein a distal end of the second treatment portion is located at a position closer to a distal side along the longitudinal axis than a distal end of the first treatment portion when the first contact surface and the second contact surface are located at the closed position, and the distal end of the second treatment portion is located at the same position as the position of the distal end of the first treatment portion or located closer to the proximal side than the distal end of the first treatment portion when the first contact surface and the second contact surface are located at the open position.", "Advantages of the invention will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.", "Advantages of the invention may be realized and obtained by means of the instrumentalities and combinations particularly pointed out hereinafter." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a Continuation Application of PCT Application No.", "PCT/JP2016/065050, filed May 20, 2016 and based upon and claiming the benefit of priority from prior Japanese Patent Application No.", "2015-142363, filed Jul.", "16, 2015, the entire contents of all of which are incorporated herein by reference.", "BACKGROUND OF THE INVENTION 1.Field of the Invention This invention relates a treatment instrument.", "2.Description of the Related Art For example, Jpn.", "Pat.", "Appln.", "KOKAI Publication No.", "2001-61848 discloses a treatment instrument which is able to coagulate a living tissue while sandwiching it between a fixed electrode on the distal side and a movable electrode which slides toward the fixed electrode along the longitudinal axis direction.", "When, for example, there is a living tissue to be treated in a body cavity or the like, the tissue is treated after the insertion of an endoscope and a treatment instrument through different trocars.", "BRIEF SUMMARY OF THE INVENTION According to one aspect of the present invention, a treatment instrument includes: a sheath which defines a longitudinal axis with a distal end and a proximal end; a first treatment portion which includes a first member including a first contact surface coming into contact with a living tissue and a second member including a second contact surface facing the first contact surface and coming into contact with the living tissue at a position closer to a proximal side than the first contact surface along the longitudinal axis and which is configured to coagulate the living tissue by applying energy to the living tissue sandwiched between the first contact surface and the second contact surface; a movement mechanism which is configured to move at least one of the first member and the second member along the longitudinal axis and to switch between a closed position where the first contact surface is close to the second contact surface and an open position where the first contact surface is separate from the second contact surface; and a second treatment portion which is juxtaposed to the first treatment portion, wherein a distal end of the second treatment portion is located at a position closer to a distal side along the longitudinal axis than a distal end of the first treatment portion when the first contact surface and the second contact surface are located at the closed position, and the distal end of the second treatment portion is located at the same position as the position of the distal end of the first treatment portion or located closer to the proximal side than the distal end of the first treatment portion when the first contact surface and the second contact surface are located at the open position.", "Advantages of the invention will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.", "Advantages of the invention may be realized and obtained by means of the instrumentalities and combinations particularly pointed out hereinafter.", "BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWING The accompanying drawings, which are incorporated in and constitute apart of the specification, illustrate embodiments of the invention, and together with the general description given above and the detailed description of the embodiments given below, serve to explain the principles of the invention.", "FIG.", "1A is a schematic view showing a treatment system according to the first embodiment while a first treatment portion is closed and a distal end of a second treatment portion is made to protrude relative to the first treatment portion toward a distal side along a longitudinal axis.", "FIG.", "1B is a schematic view showing a treatment instrument according to the first embodiment while the first treatment portion is open and the distal end of the second treatment portion is arranged on a proximal side along the longitudinal axis relative to a first contact surface of the first treatment portion.", "FIG.", "2A is a schematic view showing a treatment system according to the first modification of the first embodiment while the first treatment portion is closed and the distal end of the second treatment portion is made to protrude relative to the first treatment portion toward the distal side along the longitudinal axis.", "FIG.", "2B is a schematic view showing the treatment instrument according to the first modification of the first embodiment while the first treatment portion is open and the distal end of the second treatment portion is arranged at almost the same position along the longitudinal axis as that of the first contact surface of the first treatment portion along the longitudinal axis.", "FIG.", "3A is a schematic view showing the treatment instrument according to the second modification of the first embodiment while the first treatment portion is closed and the distal end of the second treatment portion is made to protrude relative to the first treatment portion toward the distal side along the longitudinal axis.", "FIG.", "3B is a schematic view showing the treatment instrument according to the second modification of the first embodiment when seen from the direction of an arrow 3B in FIG.", "3A.", "FIG.", "4A is a schematic view showing a treatment instrument according to a second embodiment while a first treatment portion is appropriately open and a distal end of a second treatment portion is made to protrude relative to the first treatment portion toward a distal side along the longitudinal axis.", "FIG.", "4B is a schematic view showing a treatment instrument according to the second embodiment while the first treatment portion is open and the distal end of the second treatment portion is arranged at almost the same position along the longitudinal axis as that of a first contact surface of the first treatment portion along the longitudinal axis.", "FIG.", "4C is a schematic view showing the treatment instrument according to the second embodiment while the first treatment portion is closed and the distal end of the second treatment portion is arranged at almost the same position along the longitudinal axis as that of the first contact surface of the first treatment portion along the longitudinal axis.", "FIG.", "5A is a schematic view showing a state in which the movement mechanism of a treatment instrument according to a third embodiment is operated to switch a first treatment portion in a treatment region to a closed position, and a second treatment portion is pulled into the first treatment portion.", "FIG.", "5B is a schematic view showing a state in which the movement mechanism of the treatment instrument according to the third embodiment is operated to switch the first treatment portion in the treatment region to an open position, and the second treatment portion is pulled into the first treatment portion.", "FIG.", "5C is a schematic view showing a state in which the movement mechanism of the treatment instrument according to the third embodiment is operated to switch the first treatment portion in the treatment region to the closed position, and the second treatment portion is made to protrude relative to the distal end of the first treatment portion.", "DETAILED DESCRIPTION OF THE INVENTION Hereinafter, embodiments of this invention will be described with reference to the drawings.", "The first embodiment will be described with reference to FIGS.", "1A and 1B.", "As shown in FIG.", "1A, a treatment system (treatment instrument unit) 10 according to this embodiment includes a treatment instrument 12 and a controller 14.In this case, a foot switch 16 is connected to the controller 14.A hand switch (not shown) can be provided on the treatment instrument 12 together with or instead of the foot switch 16.A patient plate P is also connected to the controller 14.As shown in FIGS.", "1A and 1B, the treatment instrument 12 includes a tubular sheath 22, a treatment region 24 protruding from a distal end 22a of the sheath 22, and a movement mechanism 26.A longitudinal axis L is defined by the distal end 22a and a proximal end 22b of the sheath 22.The sheath 22 has electrical insulation properties.", "The treatment region 24 includes a first treatment portion 32 and a second treatment portion 34.Referring to FIGS.", "1A to 2B, a distal portion of the second treatment portion 34 has a straight shape but is not specifically limited.", "It is possible to use the second treatment portion 34 having a distal portion formed into an appropriate shape such as a hook-like shape or spatula-like shape.", "In this embodiment, the first treatment portion 32 can perform bipolar treatment.", "The first treatment portion 32 includes a first member 42 and a second member 44.The first member 42 and the second member 44 each are preferably formed from a metal material having electrical conductivity.", "Note that the first member 42 and the second member 44 may be formed from the same material or different materials.", "Both the first member 42 and the second member 44 are electrically connected to the controller 14.In this embodiment, the first member 42 includes a shaft 42a extending, for example, parallel to the longitudinal axis L and an activation portion 42b obtained by bending the distal end of the shaft 42a in a direction crossing the longitudinal axis L. The activation portion 42b is bent in, for example, an almost L shape.", "Referring to FIGS.", "1A to 2B, the angle of the activation portion 42b relative to the shaft 42a is 90°.", "However, the activation portion 42b may be bent at an appropriate angle other than 90°.", "Obviously, the portion between portions 54 and 58 (to be described later), i.e., the boundary portion between the shaft 42a and the activation portion 42b, is preferably formed into a curved surface by, for example, being chamfered.", "Likewise, obviously, the boundary portion between surfaces 52 and 56 is preferably formed into a curved surface by, for example, being chamfered.", "Like the shaft 42a of the first member 42, the second member 44 extends, for example, parallel to the longitudinal axis L and is formed into, for example, a columnar rod.", "The activation portion 42b of the first member 42 includes a first contact surface 52 which treats a living tissue while being in contact with the living tissue.", "The activation portion 42b of the first member 42 protrudes relative to the distal end 22a of the sheath 22.The first contact surface 52 is directed toward the distal end 22a of the sheath 22.That is, the first contact surface 52 is directed toward the proximal side along the longitudinal axis L. The second member 44 includes a second contact surface 62 which is located at a proximal side along the longitudinal axis L than the first contact surface 52, which is directed toward the first contact surface 52, and which treats a living tissue, together with the first contact surface 52, while being in contact with the living tissue.", "The second contact surface 62 is directed toward the distal side along the longitudinal axis L. The first contact surface 52 is preferably parallel to the second contact surface 62.Obviously, the first contact surface 52 and the second contact surface 62 need not always be directed along the longitudinal axis L, and normal lines to the first contact surface 52 and the second contact surface 62 are preferably formed into slopes shifted from the longitudinal axis L. In this embodiment, the first contact surface 52 and the second contact surface 62 each are used as a high-frequency electrode.", "The first contact surface 52 and the second contact surface 62 of the first treatment portion 32 can perform bipolar treatment that can coagulate a living tissue by, for example, sealing the living tissue sandwiched between the first contact surface 52 and the second contact surface 62 by applying energy to the sandwiched living tissue.", "When the living tissue is a blood vessel, the sandwiched blood vessel is sealed by bipolar treatment.", "The first member 42 includes the electrical insulating portion 54 which prevents treatment on a living tissue when energy is applied while being in contact with the living tissue.", "The electrical insulating portion 54 is formed from, for example, an insulating coating.", "The electrical insulating portion 54 preferably has heat resistance.", "The electrical insulating portion 54 is formed on the surface reverse to the first contact surface 52.That is, the electrical insulating portion 54 is located on the distal end surface of the first member 42 and directed toward the distal side along the longitudinal axis L. The portion 56, of the shaft 42a of the first member 42, which is located near the boundary with the activation portion 42b and also near the distal end of the second member 44 may be formed as an electrode like the first contact surface 52 or may be formed as an electrical insulating portion.", "The electrical insulating portion 58 is formed on the reverse surface (far face) of the portion 56.The electrical insulating portions 54 and 58 are preferably formed seamlessly and continuously.", "The electrical insulating portion 58 is formed from, for example, an insulating coating.", "In addition to the electrical insulating portion 54, the electrical insulating portion 58 of first member 42 prevents treatment on a living tissue when the above energy is applied while being in contact with the living tissue.", "The side surfaces between the first contact surface 52 and the electrical insulating portion 54, the side surfaces between the portion 56 and the electrical insulating portion 58, and a far end 42c of the activation portion 42b of the first member 42 relative to the shaft 42a elongated along the longitudinal axis L are preferably formed as electrical insulating portions 59.Note that the far end 42c forms an opening inlet in which a living tissue is arranged between the far end 42c and the second contact surface 62 of the second member 44.The second member 44 includes an electrical insulating portion 64 which prevents treatment on a living tissue when energy is applied while being in contact with the living tissue.", "The electrical insulating portion 64 is formed on a portion other than the second contact surface 62.More specifically, an insulating coating is applied to the outer circumferential surface of the portion, of the second member 44, which is located around the longitudinal axis.", "For this reason, the sliding surface between the first member 42 and the second member 44 is electrically insulated.", "Note that the electrical insulating portion 64 preferably has heat resistance.", "The first member 42 shown in FIGS.", "1A and 1B is fixed to the sheath 22.The second member 44 can move along the longitudinal axis L relative to the sheath 22.The movement mechanism 26 can move the second member 44 within a predetermined range along the longitudinal axis L. As the movement mechanism 26, an appropriate mechanism can be used.", "For example, the movement mechanism 26 as a linear motor can be used to move the second member 44 within a predetermined range along the longitudinal axis L relative to the sheath 22.Briefly described below is an example of the movement mechanism 26 with which the user manually moves the second member 44 along the longitudinal axis L relative to the sheath 22.The sheath 22 is provided with a slot 72 which is formed longer along the longitudinal axis L than in the circumferential direction of the longitudinal axis L and defines a movement range in which the second member 44 is moved along the longitudinal axis L. The slot 72 is provided with a slide lever (slider) 74 as an operation member.", "The slide lever 74 can move between the distal end and proximal end of the slot 72 along the longitudinal axis L. The slide lever 74 has electrical insulation properties.", "The slide lever 74 is coupled to the second member 44.That is, for example, the movement mechanism 26 includes the slot 72 formed in the sheath 22 and the slide lever 74 coupled to the second member 44.When the user moves the slide lever 74 toward the distal side of the sheath 22 along the longitudinal axis L, the movement mechanism 26 can bring the slide lever 74 into contact with the distal end of the slot 72.When the user moves the slide lever 74 toward the proximal side of the sheath 22 along the longitudinal axis L, the movement mechanism 26 can bring the slide lever 74 into contact with the proximal end of the slot 72.In this manner, the slot 72 can define the movable range of the slide lever 74.When the user brings the slide lever 74 into contact with the distal end of the slot 72 of the sheath 22 along the longitudinal axis L, the first contact surface 52 of the first member 42 separates from the second contact surface 62 of the second member 44.This sets the open position where the first contact surface 52 of the first member 42 is separate from the second contact surface 62 of the second member 44.When the user brings the slide lever 74 into contact with the proximal end of the slot 72 of the sheath 22 along the longitudinal axis L, the first contact surface 52 of the first member 42 approaches the second contact surface 62 of the second member 44.This sets the closed position where the first contact surface 52 of the first member 42 is close to the second contact surface 62 of the second member 44.At this time, the first contact surface 52 is not in contact with the second contact surface 62, and a slight gap is formed between them.", "Operating the slide lever 74 can adjust the opening amount by adjusting the distance between the first contact surface 52 and the second contact surface 62.That is, the movement mechanism 26 moves the first member 42 along the longitudinal axis L to switch between the closed position where the first contact surface 52 is close to the second contact surface 62 and the open position where the first contact surface 52 is separate from the second contact surface 62.The second treatment portion 34 is formed into a rod-like shape thinner than the second member 44.FIGS.", "1A to 2B show the second treatment portion 34 extending straight along the longitudinal axis L. As described above, however, the second treatment portion 34 can have any appropriate shape.", "The second treatment portion 34 is used as, for example, a high-frequency electrode.", "The second treatment portion 34 can perform bipolar treatment to incise and peel a living tissue between the second treatment portion 34 and the patient plate P attached to the patient by applying energy to the living tissue in contact with the second treatment portion 34.The second treatment portion 34 is juxtaposed to the first treatment portion 32.When the first treatment portion 32 is switched to the closed position, the second treatment portion 34 is located at the distal side along the longitudinal axis L than the electrical insulating portion 54 of the distal end surface of the first treatment portion 32.When the first contact surface 52 and the second contact surface 62 are located at the closed position, the second treatment portion 34 is located at the distal side along the longitudinal axis L than the first treatment portion 32, and the second treatment portion 34 can incise or peel the living tissue by applying energy to the living tissue.", "When the first treatment portion 32 is switched to the open position, the second treatment portion 34 is located at the same position as that of the distal end of the first treatment portion 32 or located at the proximal side than the distal end of the first treatment portion 32.When the first treatment portion 32 is switched to the open position, the second treatment portion 34 is located at the same position as that of the first contact surface 52 of the first treatment portion 32 along the longitudinal axis L or located at the proximal side than the first contact surface 52 of the first treatment portion 32.Note that the first treatment portion 32 and the second treatment portion 34 are not electrically connected to each other and are electrically insulated.", "The first treatment portion 32 and the second treatment portion 34 are electrically insulated also by an insulating coating or the like.", "In this embodiment, the controller 14 can perform control to perform bipolar treatment using the first treatment portion 32 by outputting energy to the first treatment portion 32 in accordance with, for example, an instruction from the foot switch 16, and can also perform control to cause the second treatment portion 34 to perform monopolar treatment using the second treatment portion 34 by outputting energy to the second treatment portion 34.The foot switch 16 of the treatment system 10 according to this embodiment includes a first switch 16a and a second switch 16b.", "The first switch 16a outputs, in accordance with a pressing operation, an instruction to output energy from the controller 14 when the first treatment portion 32 performs bipolar treatment.", "The second switch 16b outputs an instruction to output energy when the second treatment portion 34 performs monopolar treatment.", "The effects of the treatment system 10 according to this embodiment will be briefly described next.", "For example, the treatment instrument 12 is used together with an endoscope (not shown) via a trocar.", "The user attaches the patient plate P to an appropriate location on a patient.", "The user appropriately holds the treatment instrument 12 and causes the treatment region 24 to face a membrane tissue or layered tissue in the body while checking an observation image of the endoscope.", "The second treatment portion 34 of the treatment region 24 has a thin shape, and hence can maintain approachability to the membrane tissue or the layered tissue in the body.", "As shown in FIG.", "1A, the first treatment portion 32 is set at the closed position, and the distal end 34a of the second treatment portion 34 is made to protrude toward the distal side along the longitudinal axis L relative to the distal end of the first treatment portion 32.The user presses the second switch 16b to cause the second treatment portion 34 of the treatment region 24 to perform monopolar treatment on the living tissue.", "The second treatment portion 34 incises a living tissue as a treatment target or peels tissue layers which is in contact with the second treatment portion 34, by applying monopolar high-frequency energy to the living tissue and recovers a high-frequency current via the patient plate P attached to the patient.", "Note that the user presses the second switch 16b only when actually performing treatment such as incision, and normally keeps the second switch 16b unpressed.", "The first treatment portion 32 and the second treatment portion 34 are electrically insulated.", "For this reason, in monopolar treatment using the second treatment portion 34, no current flows in the first treatment portion 32.When the electrical insulating portions 54, 58, and 59 of the first treatment portion 32 come into contact with a living tissue at an appropriate position, no current flows in the living tissue in contact with the portions.", "This prevents a high-frequency current from accidentally flowing from the electrical insulating portions 54, 58, and 59 of the first treatment portion 32 to the living tissue.", "That is, this prevents the treatment region 24 from performing unintended treatment.", "When repeatedly incising a filmy living tissue or peels tissue layers, a blood vessel is sometimes exposed.", "In this case, the second treatment portion 34 seals the blood vessel, that is, coagulates the blood vessel, to prevent bleeding from the blood vessel.", "More specifically, the user operates the slide lever 74 along the slot 72 to switch the first contact surface 52 of the first member 42 and the second contact surface 62 of the second member 44 to the open position, as shown in FIG.", "1B.", "The distal end of the first treatment portion 32 is protruded from the distal end 34a of the second treatment portion 34.More specifically, the first contact surface 52 of the first treatment portion 32 is protruded from the distal end 34a of the second treatment portion 34.This makes it difficult for the distal end 34a of the second treatment portion 34 to obstruct, for example, the operation of bringing the blood vessel into contact with the first contact surface 52 of the first member 42.In this state, the blood vessel is arranged between the first contact surface 52 of the first member 42 of the first treatment portion 32 and the second contact surface 62 of the second treatment portion 34.As shown in FIG.", "1A, the user moves the slide lever 74 to switch the first contact surface 52 of the first member 42 and the second contact surface 62 of the second member 44 to the closed position.", "At this time, the blood vessel comes into contact with both the first contact surface 52 of the first member 42 and the second contact surface 62 of the second member 44.The first contact surface 52 is not electrically connected to the second contact surface 62.In this state, the user presses the first switch 16a to cause the first treatment portion 32 to perform bipolar treatment on a living tissue as a treatment target such as a blood vessel.", "The blood vessel (living tissue) as a treatment target which is in contact with both the first contact surface 52 of the first member 42 of the first treatment portion 32 and the second contact surface 62 of the second member 44 is coagulated by Joule heat on applying high-frequency energy to the blood vessel.", "This prevents bleeding from the coagulated portion.", "When incising the blood vessel, the user switches the first treatment portion 32 to the open position to release the blood vessel and then switches the portion to the closed position.", "The coagulated portion of the blood vessel is incised by the second treatment portion 34.At this time, the user is only required to move the treatment region 24 and need not interchange the treatment instrument 12 itself by, for example, removing it from the trocar.", "Note that when the user switches the first treatment portion 32 from the open position to the closed position or from the closed position to the open position, the first member 42 and the second member 44 only move back and forth relatively.", "This leads to a simple structure, which is less likely to degrade visibility when a blood vessel or the like is arranged between the first contact surface 52 of the first member 42 and the second contact surface 62 of the second member 44.Subsequently, as the user performs monopolar treatment such as incision using the second treatment portion 34, the user performs bipolar treatment using the first treatment portion 32 if, for example, the blood vessel is exposed.", "If necessary, the user performs monopolar treatment using the second treatment portion 34 to, for example, incise the blood vessel sealed by bipolar treatment, thus finishing the desired treatment.", "As described above, the treatment instrument 12 according to this embodiment has the following effects.", "When the first contact surface 52 and the second contact surface 62 are located at the closed position, the distal end 34a of the second treatment portion 34 is located closer to the distal side along the longitudinal axis L than the distal end of the first treatment portion 32.This enables the second treatment portion 34 to perform treatment such as incision or peeling, as needed, with respect to a living tissue as a treatment target while the first treatment portion 32 is located at the closed position.", "When the first contact surface 52 and the second contact surface 62 are located at the open position, the distal end 34a of the second treatment portion 34 is located at the same position as that of the distal end of the first treatment portion 32 or located closer to the proximal side than the distal end of the first treatment portion 32.Even if, for example, a blood vessel is exposed, when the first treatment portion 32 is switched to the open position, the distal end of the first treatment portion 32, specifically, the first contact surface 52 is able to be arranged closer to the distal side than the distal end 34a of the second treatment portion 34.Thus, it is easy to bring the blood vessel into contact with the first contact surface 52.When the blood vessel is arranged on the first contact surface 52, it is easy to bring the blood vessel into contact with both the first contact surface 52 and the second contact surface 62 while being less likely to be influenced by the presence of the second treatment portion 34.When the first treatment portion 32 is located at the closed position, the distal end 34a of the second treatment portion 34 is located closer to the distal side along the longitudinal axis L than the distal end of the first treatment portion 32; however, when the first treatment portion 32 is switched to the open position, a part of the first treatment portion 32 is located closer to the distal side along the longitudinal axis L than the distal end 34a of the second treatment portion 34.Therefore, using the treatment instrument 12 according to this embodiment makes it easy for the user to perform treatment such as sealing a living tissue such as a blood vessel, as needed, using the first treatment portion 32.After the blood vessel is sealed, the user can proceed with treatment such as incising or peeling a living tissue as a treatment target using the second treatment portion 34 while maintaining a state in which the treatment region 24 is located close to the living tissue as the treatment target.", "The user can therefore proceed with treatment on a living tissue as a treatment target using one treatment instrument 12 while maintaining a state in which the treatment region 24 is located close to the living tissue without interchanging the treatment instrument.", "This can shorten the treatment time and greatly improve the treatment efficiency of a living tissue as a treatment target by using the treatment instrument 12.When, for example, using the treatment instrument 12 together with an endoscope, there is no need to interchange the treatment instrument 12.This makes it possible to always keep the treatment region 24 close a treatment target while arranging the treatment region 24 within the observation field of view of the endoscope.", "For this reason, once the user set the treatment region 24 within the field of view of the endoscope, it is not necessary to arrange the treatment region 24 within the field of view of the endoscope again.", "That is, once the user makes the treatment region 24 face a living tissue as a treatment target, he/she can proceed with treatment while the treatment region 24 is arranged within the field of view of the endoscope.", "Note that the treatment system 10 according to this embodiment has been described by exemplifying the case of performing monopolar treatment using the second treatment portion 34.The second treatment portion 34 is formed thinner than the first treatment portion 32.For this reason, the second treatment portion 34 can perform more elaborate treatment than the first treatment portion 32.The second treatment portion 34 can proceed with treatment on a living tissue without requiring the application of any energy from the controller 14, for example, separating an exposed blood vessel from the living tissue by hooking the blood vessel.", "The first contact surface 52 of the first member 42 can also be suitably used as a first heater (not shown) instead of a high-frequency electrode.", "The second contact surface 62 of the second member 44 can also be suitably used as a second heater (not shown) instead of a high-frequency electrode.", "When the first contact surface 52 and the second contact surface 62 are not used as high-frequency electrodes in this manner, the first contact surface 52 and the second contact surface 62 may come into contact with each other.", "Note that the first and second heaters each are preferably formed into a plate-like shape which can raise temperature to about several hundred degrees Celsius in several sec.", "The treatment instrument 12 described here can be used in the same manner as the treatment instrument 12 described in the first embodiment.", "Using the first and second heaters allows the first treatment portion 32 to perform treatment of coagulating a living tissue or sealing a blood vessel.", "In addition, using the first and second heaters can incise the living tissue as well as coagulating it, depending on an energy amount setting.", "In this manner, energy used for treatment using the treatment instrument 12 is not limited to high-frequency energy, and thermal energy can be used as needed.", "Note that the treatment instrument 12 may include at least one of the first and second heaters.", "The first contact surface 52 of the first treatment portion 32 may be formed as an electrode, while the first heater may be embedded in the first contact surface 52.The second contact surface 62 of the first treatment portion 32 may be formed as an electrode, while the second heater may be embedded in the second contact surface 62.That is, the first contact surface 52 and the second contact surface 62 of the first treatment portion 32 are used both as high-frequency electrodes and heaters.", "In this case, the first contact surface 52 and the second contact surface 62 are inhibited from coming into contact with each other.", "A living tissue such as a blood vessel can be coagulated or incised by thermal energy from the heaters while the living tissue is coagulated by high-frequency energy.", "For example, it takes much time to seal a relatively thick blood vessel or the like using high-frequency energy.", "However, using both high-frequency energy and thermal energy from the heaters can improve the treatment performance and shorten the time required for sealing the blood vessel.", "In addition, heat transfer from the heaters can be used with respect to the second treatment portion 34 instead of performing monopolar high-frequency energy treatment.", "Using heat transfer can also perform treatment similar to that using high-frequency energy, for example, incision of a living tissue or peeling of tissue layers.", "The first modification of the first embodiment will be described next with reference to FIGS.", "2A and 2B.", "As shown in FIGS.", "2A and 2B, the second member 44 is fixed to the distal end of the sheath 22.The second member 44 includes first and second through holes 44a and 44b.", "The first and second through holes 44a and 44b are preferably provided with insulating coatings.", "The shaft 42a of the first member 42 extends through the first through hole 44a.", "The second treatment portion 34 extends through the second through hole 44b.", "The first member 42 of the first treatment portion 32 is electrically insulated from the second member 44 of the first treatment portion 32.The second treatment portion 34 is electrically insulated from the second member 44 of the first treatment portion 32.A first switch 18a and a second switch 18b are provided on the outer circumferential surface of the sheath 22.When, for example, the first switch 18a is pressed by the user, the controller 14 outputs an instruction to output energy to perform bipolar treatment using the first treatment portion 32.In addition, when, for example, the second switch 18b is pressed by the user, the controller 14 outputs an instruction to output energy to perform monopolar treatment using the second treatment portion 34.Obviously, in addition to operating the switches 18a and 18b on the outer circumferential surface of the sheath, operating the foot switch 16 can also perform energy output control.", "The treatment instrument 12 according to this modification can be used in the same manner as the treatment instrument 12 described in the first embodiment, and hence a description of effects will be omitted.", "The second modification of the first embodiment will be described next with reference to FIGS.", "3A and 3B.", "As shown in FIG.", "3A, the second member 44 is fixed to the distal end of the sheath 22.The second member 44 has a through hole 44a.", "The through hole 44a is preferably provided with an insulating coating.", "The shaft 42a of the first member 42 of the first treatment portion 32 extends through the through hole 44a.", "As shown in FIG.", "3B, a channel (concave surface) 43 is formed in the shaft 42a of the first member 42 of the first treatment portion 32.The channel 43 is formed into an almost U-shape when seen in a cross-section perpendicular to the longitudinal axis L. The channel 43 extends from the distal end to the proximal end of the shaft 42a.", "The channel 43 is preferably provided with an insulating coating.", "The channel 43 is provided with the second treatment portion 34.The first member 42 of the first treatment portion 32 is electrically insulated from the second member 44 of the first treatment portion 32.The second treatment portion 34 is electrically insulated from the first member 42 and the second member 44 of the first treatment portion 32.The treatment instrument 12 according to this modification can be used in the same manner as the treatment instrument 12 described in the first embodiment, and hence a description of effects will be omitted.", "Although the channel 43 has been described as having a U shape, it is obvious that the channel 43 can be formed into a tubular channel.", "In addition, when, for example, the distal portion of the second treatment portion 34 has a hook shape, the distal end of the channel 43, i.e., the distal end surface of the first member 42 of the first treatment portion 32 preferably has a slot having a shape which can accommodate the distal portion of the second treatment portion 34.The second embodiment will be described next with reference to FIGS.", "4A to 4C.", "This embodiment is a modification of the first embodiment including each modification.", "When possible, the same reference numerals as those in the first embodiment denote the same members or members having the same functions as in the second embodiment, and a detailed description of them will be omitted.", "As shown in FIGS.", "4A to 4C, a slide lever 74 is not fixed to a first member 42 of a first treatment portion 32 but is fixed to a second member 44.As shown in FIG.", "4A, the first member 42 and the second member 44 of the first treatment portion 32 are coupled to each other through an energizing member 46.The portion of the second member 44 which is coupled to the energizing member 46 preferably has electrical insulation properties.", "For this reason, the first member 42 and the second member 44 are electrically insulated from each other.", "Note that the energizing member 46 itself is preferably formed from a material having electrical insulation properties.", "As the energizing member 46, for example, a compression spring such as a compression coil spring is preferably used.", "For this reason, the energizing member 46 separates a first contact surface 52 of the first member 42 from a second contact surface 62 of the second member 44 of the first treatment portion 32.The effects of a treatment instrument 12 according to this embodiment will be described next.", "As shown in FIG.", "4A, the slide lever 74 is arranged at the proximal end of the slot 72.In this case, an engagement portion 48 of the first member 42 is located at the proximal side along a longitudinal axis L than the distal end 22a of the sheath 22.In this case, the distal end 34a of the second treatment portion 34 protrudes toward the distal side along the longitudinal axis L relative to the distal end of the first treatment portion 32.For example, the second treatment portion 34 can perform monopolar treatment such as incising a living tissue or peeling tissue layers.", "If, for example, a blood vessel is exposed due to treatment using the second treatment portion 34, the user moves the slide lever 74 from the proximal end to the distal end of the slot 72, as shown in FIG.", "4B.", "The second contact surface 62 of the second member 44 moves toward the distal side along the longitudinal axis L. At this time, the energizing force of the energizing member 46 moves the first member 42 toward the distal side along the longitudinal axis L in conjunction with the second member 44.That is, the energizing member 46 can move the first member 42 and the second member 44 together.", "The energizing member 46 then keeps the first contact surface 52 of the first member 42 of the first treatment portion 32 separated from the second contact surface 62 of the second member 44.When the user moves the slide lever 74 from the proximal end to the distal end of the slot 72, the engagement portion 48 of the first member 42 engages with the distal end 22a of the sheath 22.At this time, the first contact surface 52 of the first member 42 is located at almost the same position as that of the distal end 34a of the second treatment portion 34 or located at the distal side than the distal end 34a of the second treatment portion 34.In this state, for example, a blood vessel is brought into contact with the first contact surface 52.When the user further moves the slide lever 74 from the proximal end to the distal end of the slot 72, the first member 42 engages with the sheath 22 via the engagement portion 48 and is restricted from moving toward the distal side along the longitudinal axis L. The operating force applied to the slide lever 74 by the user moves the second member 44 toward the distal side along the longitudinal axis L against the energizing force of the energizing member 46.As shown in FIG.", "4C, when the user moves the slide lever 74 toward the distal end of the slot 72, the second contact surface 62 of the second member 44 approaches the first contact surface 52 of the first member 42 against the energizing force of the energizing member 46 while the position of the first member 42 relative to the distal end 22a of the sheath 22 is maintained.", "The slide lever 74 allows the second contact surface 62 of the second member 44 to approach the first contact surface 52 of the first member 42 as the first member 42 moves from the proximal side to the distal side along the longitudinal axis L against the energizing force of the energizing member 46 while engaging with the sheath 22 via the engagement portion 48.That is, the movement mechanism 26 according to this embodiment moves the second member 44 along the longitudinal axis L and can switch between the closed position where the first contact surface 52 is close to the second contact surface 62 and the open position where the first contact surface 52 is separate from the second contact surface 62.This allows the first treatment portion 32 to perform bipolar treatment on a blood vessel.", "The first treatment portion 32 can therefore seal a blood vessel or the like.", "In this manner, when the user operates only the single slide lever 74, both of the first member 42 and the second member 44 can move relative to the sheath 22.The second member 44 can be made to approach the first member 42 by operating the slide lever 74 in accordance with the intention of the user from a state in which the first member 42 engages with the distal end 22a of the sheath 22.For this reason, only moving the slide lever 74 relative to the sheath 22 can move the second member 44 along the longitudinal axis L and perform appropriate treatment using the first treatment portion 32 while the first member 42 is positioned.", "This embodiment has exemplified the case in which one end of the energizing member 46 is coupled to the first member 42, and the other end is coupled to the second member 44.Even if, however, one end of the energizing member 46 is coupled to the first member 42 and the other end is coupled to the slide lever (slider) 74, the first member 42 and the second member 44 can be moved in the same manner as described above.", "The third embodiment will be described with reference to FIGS.", "5A to 5C.", "This embodiment is a modification of the first and second embodiments.", "When possible, the same reference numerals as those in the first and embodiments denote the same members or members having the same functions as in the third embodiment, and a detailed description of them will be omitted.", "The first embodiment has exemplified the case in which the first contact surface 52 of the first member 42 can be located at the same position as that of the distal end 34a of the second treatment portion 34 or located closer to the distal side than the distal end 34a of the second treatment portion 34 by moving the first member 42 of the first treatment portion 32 relative to the distal end 22a of the sheath 22 along the longitudinal axis L. The second embodiment has exemplified the case in which the first contact surface 52 of the first member 42 can be located at the same position as that of the distal end 34a of the second treatment portion 34 or located closer to the distal side than the distal end 34a of the second treatment portion 34 by moving the first member 42 and the second member 44 of the first treatment portion 32 relative to the distal end 22a of the sheath 22 along the longitudinal axis L. As shown in FIGS.", "5A to 5C, the second treatment portion 34 may be made movable relative to the distal end 22a of the sheath 22 along the longitudinal axis L. That is, the amount of protrusion of the distal end 34a of the second treatment portion 34 relative to the distal end 22a of the sheath 22 may be made adjustable.", "This also makes it possible to locate the first contact surface 52 of the first member 42 of the first treatment portion 32 at the same position as that of the distal end 34a of the second treatment portion 34 or at a position closer to the distal side than the distal end 34a of the second treatment portion 34.The first member 42 of the first treatment portion 32 includes a channel 92 formed parallel to the longitudinal axis L and having an insulated inner circumferential surface.", "In this case, the channel 92 is formed in the surface reverse to a portion 56.A movement mechanism 26 includes the slot 72, the first slide lever 74a, and a second slide lever 74b.", "The slot 72 is commonly used for the first slide lever 74a and the second slide lever 74b.", "The first slide lever 74a is arranged closer to the distal side in the slot 72 along the longitudinal axis L than the second slide lever 74b.", "The first slide lever 74a is coupled to the second treatment portion 34.The second slide lever 74b is coupled to the shaft 42a of the first member 42 of the first treatment portion 32.When no treatment is to be performed, the first slide lever 74a and the second slide lever 74b are located closest to the proximal side in the slot 72, as shown in FIG.", "5A.", "That is, the first treatment portion 32 is switched to the closed position, and the second treatment portion 34 is located closer to the proximal side than the distal end of the activation portion 42b of the first member 42 of the first treatment portion 32.When the first treatment portion 32 seals a blood vessel or the like, the first slide lever 74a and the second slide lever 74b are located closest to the distal side in the slot 72, as shown in FIG.", "5B.", "That is, the first treatment portion 32 is switched to the open position, and the second treatment portion 34 is located closer to the proximal side than the distal end of the activation portion 42b of the first member 42 of the first treatment portion 32.When the second treatment portion 34 incises a membrane or peels a living tissue, the first slide lever 74a is located closest to the distal side in the slot 72, and the second slide lever 74b is located closest to the proximal side, as shown in FIG.", "5C.", "That is, the first treatment portion 32 is switched to the closed position, and the second treatment portion 34 is made to protrude relative to the distal end of the activation portion 42b of the first member 42 of the first treatment portion 32.This allows the second treatment portion 34 to protrude to the distal side along the longitudinal axis L relative to the first member 42 of the first treatment portion 32.While the user performs treatment using the treatment instrument 12 when the treatment region 24 is arranged at an appropriate position, the user moves the first and second slide levers 74a and 74b of the movement mechanism 26 to the state shown in FIG.", "5A or the state shown in FIG.", "5C.", "The user then moves the first and second slide levers 74a and 74b to the state shown in FIG.", "5C, and makes the second treatment portion 34 protrude relative to the distal end of the activation portion 42b of the first member 42 of the first treatment portion 32.In this state, for example, the user presses the second switch 16b of the foot switch 16 to perform monopolar treatment on a living tissue using the second treatment portion 34 of the treatment region 24.The second treatment portion 34 incises a living tissue such as a membrane or peels tissue layers which is in contact with the second treatment portion 34.If, for example, a blood vessel is exposed, the user moves the first and second slide levers 74a and 74b to the state shown in FIG.", "5B to switch the first treatment portion 32 to the open position and pull the second treatment portion 34 into the channel 92 relative to the first treatment portion 32.In this state, the blood vessel is arranged between the first contact surface 52 of the first member 42 of the first treatment portion 32 and the second contact surface 62 of the second treatment portion 34.When the user moves the first and second slide levers 74a and 74b to the state shown in FIG.", "5A or 5C to switch the first treatment portion 32 to the closed position, the blood vessel is brought into contact with both the first contact surface 52 of the first member 42 and the second contact surface 62 of the second member 44.In this state, for example, the user presses the first switch 16a of the foot switch 16 to perform bipolar treatment on a living tissue as a treatment target such as a blood vessel using the first treatment portion 32, thus sealing the blood vessel.", "As described above, when, for example, the first treatment portion 32 performs treatment, the second treatment portion 34 can be accommodated in the first treatment portion 32, as shown in FIGS.", "5A and 5B.", "This can prevent the second treatment portion 34 from becoming an obstruction.", "Additional advantages and modifications will readily occur to those skilled in the art.", "Therefore, the invention in its broader aspects is not limited to the specific details and representative embodiments shown and described herein.", "Accordingly, various modifications may be made without departing from the spirit or scope of the general inventive concept as defined by the appended claims and their equivalents." ] ]
Patent_15872613
[ [ "FIXATION SLEEVE EQUIPPED LEADLESS PULSE GENERATOR", "A leadless pulse generator is disclosed herein.", "The leadless pulse generator has a body, a helical anchor, an electrode, and a sleeve.", "The body includes a distal end and a proximal end opposite the distal end.", "The helical anchor distally extends from the distal end.", "The electrode is at the distal end.", "The sleeve distally extends from the distal end and has a proximal face and a distal face opposite the proximal face.", "The proximal face is adjacent the body.", "The sleeve coaxially extends about the helical anchor and further has a biased state wherein the distal face is near a distal tip of the helical anchor.", "The sleeve is configured to compress such that the distal face displaces proximally towards the proximal face upon the distal face being forced against the cardiac tissue in the course of the helical anchor screwing into the cardiac tissue." ], [ "1.A method of manufacturing a leadless pulse generator, the method comprising: positioning a distal electrode of the leadless pulse generator within a hollow interior of a compressible fixation sleeve including at least a radiopaque portion; and coupling the compressible fixation sleeve to the housing of the leadless pulse generator by coupling an anchor mount to the housing such that a portion of the compressible fixation sleeve is sandwiched between the anchor mount and a portion of the housing.", "2.The method of claim 1, wherein the portion of the compressible fixation sleeve comprises an inner annular ring.", "3.The method of claim 1, wherein the housing comprises a distal protrusion that boarders the distal electrode and is also positioned in the hollow inferior.", "4.The method of claim 3, wherein the distal protrusion mechanically couples with the anchor mount when the anchor mount is coupled to the housing.", "5.The method of claim 4, wherein the distal protrusion and the anchor mount threadably engage with each other in the course of being mechanically coupled with each other." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Leadless pulse generators have a helical anchor at a distal end of the leadless pulse generator.", "The helical anchor is used to secure the leadless pulse generator to cardiac tissue in such a manner that an electrode of the leadless pulse generator is maintained in appropriate tissue contact for cardiac pacing and sensing.", "Since the helical anchor is fixed relative to the rest of the leadless pulse generator, the leadless pulse generator is rotated as a whole relative to the cardiac tissue to cause the helical anchor to screw into the cardiac tissue and thereby fix the leadless pulse generator to the cardiac tissue.", "Implanters make use of a chevron or other shaped radiopaque marker within the body of the device for visual feedback under fluoroscopy when rotating the leadless pulse generator to screw the helical anchor into the cardiac tissue.", "A prescribed number of turns (e.g.", "1¼ turns) of the leadless pulse generator is recommended for desirable helical anchor fixation in the cardiac tissue.", "However, verifying that the prescribed number of turns has actually resulted in actual turns of the helical anchor screwing into the cardiac tissue can be a challenge.", "This challenge results from the fact that the leadless pulse generator may be rotated for the prescribed number of turns without the helical anchor fully engaging the cardiac tissue for the entirety of the prescribed number of turns, and the radiopaque marker viewed via fluoroscopy only conveys to the implanter that rotation of the leadless pulse generator is occurring, not that the helical anchor is properly screwing into cardiac tissue.", "Consequently, there is a need in the art for an improved leadless pulse generator configuration and related methods of manufacture and use." ], [ "<SOH> BRIEF SUMMARY OF THE INVENTION <EOH>A leadless pulse generator for administering therapy to cardiac tissue is disclosed herein.", "In one embodiment, the leadless pulse generator includes a body, a helical anchor, an electrode, and a sleeve.", "The body includes a distal end and a proximal end opposite the distal end.", "The helical anchor distally extends from the distal end.", "The electrode is at the distal end.", "The sleeve distally extends from the distal end and includes a proximal face and a distal face opposite the proximal face.", "The proximal face is adjacent the body.", "The sleeve coaxially extends about the helical anchor and further includes a biased state wherein the distal face is near a distal tip of the helical anchor.", "The sleeve is configured to compress such that the distal face displaces proximally towards the proximal face upon the distal face being forced against the cardiac tissue in the course of the helical anchor screwing into the cardiac tissue.", "The sleeve may be radiopaque or include a radiopaque portion or component.", "In one embodiment, the leadless pulse generator further includes an anchor mount operably coupled to the distal end and supporting the helical anchor.", "A portion of the sleeve is sandwiched between the anchor mount and the distal end.", "The portion of the sleeve may be a radially inward extending annular ring.", "The electrode may be exposed at a center of the anchor mount, and the anchor mount may be threadably, interference or press fit, swaged, welded, or otherwise operably coupled to the distal end.", "In one embodiment, the sleeve includes a proximal section extending distally from the proximal face and a distal section extending proximally from the distal face.", "The sleeve is configured such that, in the course of the helical anchor screwing into the cardiac tissue and the distal face being forced against the cardiac tissue, the distal section folds proximally and the distal face increases in diameter.", "In one embodiment, when the sleeve is in the biased state, the distal section includes a conical outer shape and the proximal section includes a cylindrical outer shape.", "The conical outer shape distally increases in diameter, The distal face may change from facing distally to facing radially outward when the distal face displaces proximally towards the proximal face.", "In one embodiment, the distal section includes a series of longitudinally extending gaps and longitudinally extending members.", "The members distally terminate as part of the distal face.", "The gaps and members are arranged in a uniformly spaced alternating fashion about a circumference of the distal section.", "The members may be wider than the gaps, or the gaps may be wider than the members.", "The members may change from projecting distally to projecting radially outward when the distal face displaces proximally towards the proximal face.", "In one embodiment, the sleeve includes a proximal cylindrical section extending distally from the proximal face and a distal bellows section extending proximally from the distal face.", "The distal bellows section includes first and second radially outward projecting circumferentially extending ridges and a radially inward projecting circumferentially extending valley located between the first and second ridges.", "The sleeve is configured such that, in the course of the helical anchor screwing into the cardiac tissue and the distal face being forced against the cardiac tissue, the first ridge moves proximally towards the second ridge and the valley decreases in dimension distal-proximal.", "A method of manufacturing a leadless pulse generator is also disclosed herein.", "In one embodiment, the method includes: positioning a distal electrode of the leadless pulse generator within a hollow interior of a compressible fixation sleeve including at least a radiopaque portion; and coupling the compressible fixation sleeve to the housing of the leadless pulse generator by coupling an anchor mount to the housing such that a portion of the compressible fixation sleeve is sandwiched between the anchor mount and a portion of the housing.", "The sandwiched portion of the compressible fixation sleeve may be in the form of an inner annular ring.", "The housing may include a distal protrusion that boarders the distal electrode and is also positioned in the hollow interior.", "The distal protrusion may mechanically couple with the anchor mount when the anchor mount is coupled to the housing.", "For example, the distal protrusion and the anchor mount may threadably engage with each other in the course of being mechanically coupled with each other.", "While multiple embodiments are disclosed, still other embodiments of the present disclosure will become apparent to those skilled in the art from the following detailed description, which shows and describes illustrative embodiments of the disclosure.", "As will be realized, the invention is capable of modifications in various aspects, all without departing from the spirit and scope of the present disclosure.", "Accordingly, the drawings and detailed description are to be regarded as illustrative in nature and not restrictive." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This is a division of U.S. patent application Ser.", "No.", "14/884,619, filed Oct. 15, 2015.FIELD OF THE INVENTION Aspects of the present invention relate to medical apparatus and methods.", "More specifically, the present disclosure relates to leadless pulse generators equipped with fixation sleeves.", "The present disclosure also relates to methods of manufacturing and using such leadless pulse generators.", "BACKGROUND OF THE INVENTION Leadless pulse generators have a helical anchor at a distal end of the leadless pulse generator.", "The helical anchor is used to secure the leadless pulse generator to cardiac tissue in such a manner that an electrode of the leadless pulse generator is maintained in appropriate tissue contact for cardiac pacing and sensing.", "Since the helical anchor is fixed relative to the rest of the leadless pulse generator, the leadless pulse generator is rotated as a whole relative to the cardiac tissue to cause the helical anchor to screw into the cardiac tissue and thereby fix the leadless pulse generator to the cardiac tissue.", "Implanters make use of a chevron or other shaped radiopaque marker within the body of the device for visual feedback under fluoroscopy when rotating the leadless pulse generator to screw the helical anchor into the cardiac tissue.", "A prescribed number of turns (e.g.", "1¼ turns) of the leadless pulse generator is recommended for desirable helical anchor fixation in the cardiac tissue.", "However, verifying that the prescribed number of turns has actually resulted in actual turns of the helical anchor screwing into the cardiac tissue can be a challenge.", "This challenge results from the fact that the leadless pulse generator may be rotated for the prescribed number of turns without the helical anchor fully engaging the cardiac tissue for the entirety of the prescribed number of turns, and the radiopaque marker viewed via fluoroscopy only conveys to the implanter that rotation of the leadless pulse generator is occurring, not that the helical anchor is properly screwing into cardiac tissue.", "Consequently, there is a need in the art for an improved leadless pulse generator configuration and related methods of manufacture and use.", "BRIEF SUMMARY OF THE INVENTION A leadless pulse generator for administering therapy to cardiac tissue is disclosed herein.", "In one embodiment, the leadless pulse generator includes a body, a helical anchor, an electrode, and a sleeve.", "The body includes a distal end and a proximal end opposite the distal end.", "The helical anchor distally extends from the distal end.", "The electrode is at the distal end.", "The sleeve distally extends from the distal end and includes a proximal face and a distal face opposite the proximal face.", "The proximal face is adjacent the body.", "The sleeve coaxially extends about the helical anchor and further includes a biased state wherein the distal face is near a distal tip of the helical anchor.", "The sleeve is configured to compress such that the distal face displaces proximally towards the proximal face upon the distal face being forced against the cardiac tissue in the course of the helical anchor screwing into the cardiac tissue.", "The sleeve may be radiopaque or include a radiopaque portion or component.", "In one embodiment, the leadless pulse generator further includes an anchor mount operably coupled to the distal end and supporting the helical anchor.", "A portion of the sleeve is sandwiched between the anchor mount and the distal end.", "The portion of the sleeve may be a radially inward extending annular ring.", "The electrode may be exposed at a center of the anchor mount, and the anchor mount may be threadably, interference or press fit, swaged, welded, or otherwise operably coupled to the distal end.", "In one embodiment, the sleeve includes a proximal section extending distally from the proximal face and a distal section extending proximally from the distal face.", "The sleeve is configured such that, in the course of the helical anchor screwing into the cardiac tissue and the distal face being forced against the cardiac tissue, the distal section folds proximally and the distal face increases in diameter.", "In one embodiment, when the sleeve is in the biased state, the distal section includes a conical outer shape and the proximal section includes a cylindrical outer shape.", "The conical outer shape distally increases in diameter, The distal face may change from facing distally to facing radially outward when the distal face displaces proximally towards the proximal face.", "In one embodiment, the distal section includes a series of longitudinally extending gaps and longitudinally extending members.", "The members distally terminate as part of the distal face.", "The gaps and members are arranged in a uniformly spaced alternating fashion about a circumference of the distal section.", "The members may be wider than the gaps, or the gaps may be wider than the members.", "The members may change from projecting distally to projecting radially outward when the distal face displaces proximally towards the proximal face.", "In one embodiment, the sleeve includes a proximal cylindrical section extending distally from the proximal face and a distal bellows section extending proximally from the distal face.", "The distal bellows section includes first and second radially outward projecting circumferentially extending ridges and a radially inward projecting circumferentially extending valley located between the first and second ridges.", "The sleeve is configured such that, in the course of the helical anchor screwing into the cardiac tissue and the distal face being forced against the cardiac tissue, the first ridge moves proximally towards the second ridge and the valley decreases in dimension distal-proximal.", "A method of manufacturing a leadless pulse generator is also disclosed herein.", "In one embodiment, the method includes: positioning a distal electrode of the leadless pulse generator within a hollow interior of a compressible fixation sleeve including at least a radiopaque portion; and coupling the compressible fixation sleeve to the housing of the leadless pulse generator by coupling an anchor mount to the housing such that a portion of the compressible fixation sleeve is sandwiched between the anchor mount and a portion of the housing.", "The sandwiched portion of the compressible fixation sleeve may be in the form of an inner annular ring.", "The housing may include a distal protrusion that boarders the distal electrode and is also positioned in the hollow interior.", "The distal protrusion may mechanically couple with the anchor mount when the anchor mount is coupled to the housing.", "For example, the distal protrusion and the anchor mount may threadably engage with each other in the course of being mechanically coupled with each other.", "While multiple embodiments are disclosed, still other embodiments of the present disclosure will become apparent to those skilled in the art from the following detailed description, which shows and describes illustrative embodiments of the disclosure.", "As will be realized, the invention is capable of modifications in various aspects, all without departing from the spirit and scope of the present disclosure.", "Accordingly, the drawings and detailed description are to be regarded as illustrative in nature and not restrictive.", "BRIEF DESCRIPTION OF THE DRAWINGS The description will be more fully understood with reference to the following figures, which are presented as various embodiments of the disclosure and should not be construed as a complete recitation of the scope of the disclosure, wherein: FIG.", "1 is a diagrammatic depiction of a leadless electrotherapy system electrically coupled to a patient heart as viewed from an anterior side of the patient heart.", "FIG.", "2A is a side view of a leadless pulse generator that is generally representative of any of the leadless pulse generators depicted in FIG.", "1.FIG.", "2B is a distal end view of the leadless pulse generator of FIG.", "2A.", "FIG.", "2C is a side view of the leadless pulse generator as it appears via fluoroscopy and depicting a chevron-shaped rotation direction indicator that is part of the leadless pulse generator.", "FIG.", "3 is a side view of the leadless pulse generator of FIGS.", "2-A-2C, except illustrating the leadless pulse generator as being equipped with a compressible radiopaque (or at least partially radiopaque) fixation sleeve.", "FIG.", "4A is an enlarged side view of the compressible fixation sleeve employed with the leadless pulse generator of FIG.", "3.FIG.", "4B is an end view of the compressible fixation sleeve of FIG.", "4A.", "FIGS.", "5 and 6 are both the same view of the leadless pulse generator depicted in FIG.", "3, except showing the progressive assembly of the sleeve onto the distal end of the leadless pulse generator.", "FIGS.", "7A and 7B are, respectively, a side elevation and a cross-sectional elevation of a bellows radiopaque (or at least partially radiopaque) compressible fixation sleeve in a non-compressed state about an anchor mount and its anchor.", "FIGS.", "7C and 7D are, respectively, a side elevation and a cross-sectional elevation of the bellows radiopaque (or at least partially radiopaque) compressible fixation sleeve in a compressed state about the anchor mount and its anchor.", "FIG.", "8A is a side elevation of a tubular radiopaque (or at least partially radiopaque) compressible fixation sleeve in a non-compressed state about an anchor mount and its anchor.", "FIG.", "8B is the same view as FIG.", "8A, except showing the tubular sleeve in a compressed state about the anchor mount and its anchor.", "FIG.", "9A is a side elevation of a slit tubular radiopaque (or at least partially radiopaque) compressible fixation sleeve in a non-compressed state about an anchor mount and its anchor.", "FIG.", "9B is the same view as FIG.", "9A, except showing the slit tubular sleeve in a compressed state about the anchor mount and its anchor.", "FIG.", "10A is a side elevation of a tined tubular radiopaque (or at least partially radiopaque) compressible fixation sleeve in a non-compressed state about an anchor mount and its anchor.", "FIG.", "10B is the same view as FIG.", "10A, except showing the tined tubular sleeve in a compressed state about the anchor mount and its anchor.", "DETAILED DESCRIPTION The present disclosure is directed to a leadless pulse generator 120 including a compressible fixation sleeve 130 supported on a distal end of the leadless pulse generator 120, the sleeve 130 coaxially extending about a helical anchor 66 distally projecting from the distal end of the leadless pulse generator.", "At least a portion of the sleeve 130 is radiopaque.", "The sleeve 130 is configured to bias distally such that the wall structure of the sleeve circumferentially extends about the anchor 66 to protect the anchor from engagement with cardiovascular tissue in the course of tracking to an implantation site in a patient's heart.", "The sleeve 130 is configured to proximally compress as a distal face 134 of the sleeve 130 abuts against cardiac tissue into which the anchor 66 is being screwed, the distal displacement of the distal face 134 relative to the distal tip of the anchor 66 and/or the proximal face 132 of the sleeve 130 providing information to an implanter via fluoroscopy as to whether or not the anchor 66 is actually screwing into the cardiac tissue of the implant site.", "In addition to providing an indication of anchoring of the anchor 66 into cardiac tissue and protecting against inadvertent tissue damage from the anchor while implanting, relocating or retrieving the leadless pulse generator, the sleeve 130 also provides other benefits.", "Examples of such other benefits include providing resistance against over-rotation of the leadless pulse generator during implant, and a wider contact surface to reduce contact pressure and mitigate tissue damage.", "Also, the sleeve 130 can form a seal against the endocardium to reduce the possibility of effusion through a potential microperforation created by the anchor 66 extending through the thin myocardium.", "Finally, the compressible sleeve 130 can act to prevent anti-rotation of an implanted leadless pulse generator 120.Before beginning a discussion regarding the details of the fixation sleeves 130 disclosed herein, a general discussion will first be given regarding electrotherapy systems employing leadless pulse generators 120.a.", "Electrotherapy System Employing Leadless Pulse Generator FIG.", "1 is a diagrammatic depiction of a leadless electrotherapy system 100 electrically coupled to a patient heart 15 as viewed from an anterior side of the patient heart.", "The leadless electrotherapy system 100 employs one or more leadless pulse generators 120 (e.g., leadless pacemaker, leadless implantable cardioverter defibrillator (leadless-ICD), or etc.).", "As discussed in greater detail below, each leadless pulse generator 120 is substantially enclosed in a hermetic housing suitable for placement on or attachment to the inside or outside of a cardiac chamber.", "The leadless pulse generator can have two or more electrodes located within, on, or near the housing, for delivering pacing pulses to muscle of the cardiac chamber and optionally for sensing electrical activity from the muscle, and for bidirectional communication with at least one other device within or outside the body.", "The housing can contain a primary battery to provide power for pacing, sensing, and communication, for example bidirectional communication.", "The housing can optionally contain circuits for sensing cardiac activity from the electrodes.", "The housing contains circuits for receiving information from at least one other device via the electrodes and contains circuits for generating pacing pulses for delivery via the electrodes.", "The housing can optionally contain circuits for transmitting information to at least one other device via the electrodes and can optionally contain circuits for monitoring device health.", "The housing contains circuits for controlling these operations in a predetermined manner.", "In alternative embodiments, the housing may contain circuits for receiving and/or transmitting information via other communication means including, for example, Bluetooth, etc.", "In some embodiments, a leadless pulse generator 120 can be adapted for implantation into tissue in the human body.", "In a particular embodiment, a leadless cardiac pacemaker can be adapted for implantation adjacent to heart tissue on the inside or outside wall of a cardiac chamber, using two or more electrodes located on or within the housing of the pacemaker.", "for pacing the cardiac chamber upon receiving a triggering signal from at least one other device within the body.", "Self-contained or leadless pulse generators are typically fixed to an intracardiac implant site by an actively engaging mechanism such as a screw or helical member that screws into the myocardium.", "Examples of such leadless pulse generators are described in the following publications, the disclosures of which are incorporated by reference in their respective entireties herein: (1) U.S. Pat.", "No.", "8,457,742; (2) U.S.", "Published Application 2007/0088396A1; (3) U.S.", "Published Application 2007/0088397A1; (4) U.S. Pat.", "No.", "8,352,025; (5) U.S. Pat.", "No.", "7,937,148; (6) U.S. Pat.", "No.", "7,945,333; (7) U.S. Pat.", "No.", "8,010.209; and (8) Int'l Publication No.", "WO07047681A2.To begin a more detailed discussion of the features of a leadless pulse generator, reference is made to FIGS.", "2A and 2B, which are, respectively, a side view and a distal end view of a leadless pulse generator 120 as manufactured by St. Jude Medical, Inc. as its NANOSTIM™ leadless pacemaker.", "As can be understood from FIGS.", "2A and 2B, the leadless pulse generator 120 can include a hermetic housing 102 with a proximal electrode 104 at a proximal end of the leadless pulse generator and a distal electrode 112 at a distal end of the leadless pulse generator.", "As shown in FIGS.", "2A and 2B, the distal electrode 112 can be in the form of a distal tip electrode 112.In other embodiments, the distal electrode 112 can be in the form of a distal ring electrode.", "In some embodiments, the distal electrode 112 can be integrated within a helical fixation anchor 66 solely or combined with a distal tip or ring electrode.", "The distal electrode 112 and the helical anchor 66 are supported on the housing 102.The proximal electrode 104 can be disposed on the housing 102 in the form of a ring electrode 104.The helical fixation anchor 66 can be in the form of a helically wound wire or other structure capable of screwing into tissue for attaching the housing to tissue, such as heart tissue.", "The helical fixation anchor 66 can be electrically inert in that it does not act as an electrode.", "Alternatively, the anchor 66 can be electrically active wherein the anchor 66 is yet another electrode or acts as an extension of, or part of, the distal electrode 112.The housing can also include an electronics compartment 110 within the housing that contains the electronic components necessary for operation of the pulse generator.", "The hermetic housing 102 can be adapted to be implanted on or in a human heart, and can be cylindrically shaped, rectangular, spherical, or any other appropriate shape, for example.", "The housing 102 can include a conductive, biocompatible, inert, and anodically safe material such as titanium, 316L stainless steel, or other similar materials.", "The housing can further include an insulator disposed on the conductive material to separate electrodes 104 and 112.The insulator can be an insulative coating on a portion of the housing between the electrodes, and can include materials such as silicone, polyurethane, parylene, or another biocompatible and biostable electrical insulator commonly used for implantable medical devices.", "In one embodiment, a single insulator is disposed along the portion of the housing between electrodes 104 and 112.In some embodiments, the housing itself can include an insulator instead of a conductor, such as an alumina ceramic or other similar materials, and the electrodes can be disposed upon the housing.", "In one embodiment, the leadless pulse generator 120 can include a header assembly to isolate electrode 104 from electrode 112.The header assembly can be made from tecothane or another biocompatible plastic, and can contain a ceramic to metal feedthrough, a glass to metal feedthrough, or other appropriate feedthrough insulator as known in the art.", "The electrodes 104 and 112 can include pace/sense electrodes, or return electrodes.", "A low-polarization coating can be applied to the electrodes, such as platinum, platinum-iridium, iridium, iridium-oxide, titanium-nitride, carbon, or other materials commonly used to reduce polarization effects, for example.", "In FIG.", "2A, electrode 112 can be a pace/sense electrode and electrode 104 can be a return electrode.", "The electrode 104 can be a portion of the conductive housing 102 that does not include an insulator.", "As can be understood from FIG.", "2A, the leadless pulse generator 120 can also include a delivery/recovery structure 122 at the extreme proximal end of the leadless pulse generator with which a delivery device (e.g., delivery catheter) can interface in the implantation or removal of the leadless pulse generator.", "As illustrated in FIGS.", "2A and 2B, the leadless pulse generator 120 can include an anchor mount 131 that is threadably, interference or press fit, swaged, welded, or otherwise secured to the distal end of the housing 102 and extends about the distal electrode 112, which distally protrudes from a distal end of the anchor mount 131.The helical anchor 112 is affixed via mechanical means such as welding, press-fit, or other means to the anchor mount 131 such that the anchor mount being threadably or otherwise secured to the housing 102 results in the anchor 112 being secured to the housing.", "As can be understood from FIG.", "2C, which is a side view of the leadless pulse generator as it appears via fluoroscopy, the leadless pulse generator 120 can include a chevron-shaped rotation direction indicator 124 supported on, or within, the leadless pulse generator.", "The chevron 124 is radiopaque, and implanters can use the chevron shaped radiopaque marker 124 for visual feedback under fluoroscopy when rotating the leadless pulse generator to screw the helical anchor into the cardiac tissue.", "Several techniques and structures can be used for attaching the housing 102 to the interior or exterior wall of the heart as depicted in FIG.", "1.The leadless pulse generator can be delivered endocardially or epicardially through a guiding catheter.", "A torqueable catheter can be used to rotate the housing and force the helical fixation anchor 66 into heart tissue, thus affixing the fixation anchor (and also the distal electrode in FIG.", "2A) into contact with stimulatable tissue, as illustrated in FIG.", "1.Electrode 104 can serve as an indifferent electrode for sensing and pacing.", "The fixation anchor may be coated partially or in full for electrical insulation, and a steroid-eluting matrix may be included on or near the device to minimize fibrotic reaction, as is known in conventional pacing electrode-leads.", "The helical fixation anchor 66 may be fixed or extendable/retractable relative to the distal end of the leadless pulse generator 120.b.", "Compressible Radiopaque Fixation Sleeve Distally Extending from Leadless Pulse Generator Housing and Circumferentially Extending About Helical Fixation Anchor FIG.", "3 is a side view of the leadless pulse generator 120 of FIGS.", "2-A-2C, except illustrating the leadless pulse generator as being equipped with a compressible radiopaque (or at least partially radiopaque) fixation sleeve 130 that extends distally from the housing 102 or another portion of the leadless pulse generator 120 and circumferentially extends about the helical fixation anchor 66 of the leadless pulse generator.", "The sleeve 130 extends to the distal end of the helical anchor 66.During anchor fixation to the endocardium at implant, the fixation sleeve is intended to compress axially from its biased distally projecting state and optionally expand radially while the helical anchor 66 within the fixation sleeve 130 screws into cardiac tissue.", "The fixation sleeve 130 is advantageous for a number of reasons.", "First, the sleeve 130 protects cardiac tissue and traversed vasculature from potential trauma as may be caused by interaction with the helical anchor 66 during implant, explant and re-positioning.", "Second, the fixation sleeve 130 can act as an indicator of tissue engagement.", "Once the leadless pulse generator 120 begins to rotate and the anchor tip engages tissue, the fixation sleeve 130 will be compressed as the anchor/tissue engagement increases.", "Implanters will be able to visually compare the distal edge of the radiopaque fixation sleeve 130 with the helical anchor position and/or the distal end of the pacing electrode 112.Once the radiopaque fixation sleeve 130 is compressed sufficiently such that the distal edge of the sleeve is aligned with the pacing electrode 112, the implanter can be confident that the fixation is fully engaged and the electrode 112 is in contact with the tissue.", "Third and as discussed in detail below, optional anti-rotation features of the fixation sleeve 130 can prevent anchor dislodgement once the fixation sleeve is compressed.", "Since fixation sleeve compression also results in radial expansion, tine features at the end of the expanded fixation sleeve 130 can help resist anti-rotation of the leadless pulse generator 120 once helical anchor fixation is achieved.", "Fourth, if the helical anchor 66 inadvertently pierces transmurally through a very thin region of the atrial or ventricular wall, the fixation sleeve 130 may act as an effective barrier to the effusion of blood out of the heart and into the pericardial space through that micro-perforation.", "Finally, the fixation sleeve 130 can be used as a guard against over-rotation and tissue damage.", "Sleeve bonding at the base of the fixation sleeve 130, as well as radial expansion of the fixation sleeve, can act as a stop against over-rotation of the leadless pulse generator 120 and its potential resulting tissue damage.", "As the fixation sleeve 130 compresses, the surface area against the tissue will grow, thereby decreasing the contact pressure through increased contact surface area.", "Additional surface area contact will reduce the likelihood of tissue damage as compared to leadless pulse generators not equipped with the fixation sleeve.", "As can be understood from FIGS.", "4A and 4B, which are, respectively, enlarged side and end views of the fixation sleeve 130 employed with the leadless pulse generator 120 of FIG.", "3, the sleeve 130 includes a proximal face 132 and a distal face 134 opposite the proximal face.", "An exterior proximal cylindrical section 136 extends distally from the proximal face to an exterior transition 138 to an exterior distal conical section 140 that extends distally from the exterior transition 138 to the distal face 134, which has a diameter that is greater than a diameter of the proximal face 132.Thus, the exterior distal conical section 140 provides the sleeve 130 with a distally flared exterior as compared to the cylindrical exterior of the exterior proximal section 136.The sleeve 130 includes a hollow interior 142 which is defined by a series of internal surfaces including an internal proximally expanding conical section 144 distally extending from the proximal face 132 to an inner annular ring 146.An interior intermediate cylindrical section 148 extends distally from the annular ring 146 to an interior transition 150.An interior distally expanding conical section 152 extends distally from the interior transition 150 to the distal face 134.The annular ring 146 includes a proximal surface 154, a cylindrical inner surface 156 and a distal surface 158.The proximal and distal surfaces 154, 158 extend radially inward from the adjacent internal surfaces of the wall structure of the sleeve 130.The conical arrangements of the sleeve 130 depicted in FIGS.", "4A and 4B work together to facilitate the sleeve folding back on itself as the helical anchor 66 screws increasingly deeper into cardiac tissue abutting against the distal face 134 of the sleeve 130.While the embodiment depicted in FIGS.", "4A and 4B is described as having an exterior distal conical section 140 and an interior distal conical section 152, in other embodiments, these two distal conical sections 140, 152 may be simply cylindrical such that the two distal sections 140, 152 simply extend from their immediately adjacent proximal sections, the sleeve thereby having and overall cylindrical inner and outer shape over its entirety distal the annular ring 146.In one embodiment, the sleeve 130 is made of a low-durometer medical grade polymeric material such as a liquid silicone rubber (LSR) elastomer urethane, expanded polytetrafluoroethylene (EPTFE), or most any biocompatible soft thermoplastic, biocompatibie textile, or biocompatible woven composite, wherein any of the aforementioned materials form the sleeve 130 and a radiopaque additive such as platinum, platinum-iridium alloy, tantalum, tungsten, TiO2, BaSO4, or etc.", "is added throughout the sleeve.", "Alternatively, in one embodiment, the radiopaque additive could be restricted to a subsection of the sleeve such as the distal section 140 or extreme distal edge of the sleeve 130.In one embodiment, the sleeve may have a radiopaque marker in the form of a ring, beads or ring segments extending along a distal circumference or extreme distal circumferential edge of the sleeve 130.In such an embodiment, the radiopaque ring, beads or ring segments may be inserts molded into the sleeve, the inserts being in the form of a radiopaque material such as platinum, platinum-iridium alloy, tantalum, tungsten, TiO2, BaSO4, or etc.", "To discuss the assembly of the sleeve 130 onto the distal end of the leadless pulse generator 120, reference is made to FIGS.", "5 and 6, which are both the same view of the leadless pulse generator 120 depicted in FIG.", "3, except showing the progressive assembly of the sleeve onto the distal end of the leadless pulse generator.", "As shown in FIG.", "5, the anchor mount 131 and helical anchor 66 are absent from the distal end of the leadless pulse generator 120, revealing a threaded distal protrusion 160 of the housing 102, the protrusion 160 extending circumferentially about the distal electrode 112.To begin the assembly, the sleeve 130 is coaxially aligned with the longitudinal axis of the leadless pulse generator with the proximal face 132 of the sheath 130 facing the distal end of the leadless pulse generator 130 and the distal face 134 of the sheath 130 facing away from the leadless pulse generator.", "As shown in FIG.", "6 and with reference to FIGS.", "4A, 4B and 5, the sleeve 130 is then seated against the distal end of the leadless pulse generator 120 such that the threaded distal protrusion 160 and electrode 112 extend through the hollow interior 142 of the sleeve 130, the proximal conical surface 144 of the sleeve matingly abutting against a complementary conical surface of the distal end of the housing 102, the proximal surface 154 of the inner annular ring 148 of the sleeve abutting against a distal face of the distal end of the housing 102, and the cylindrical inner surface 156 of the annular ring 146 of the sleeve 130 making circumferential surface contact with an outer cylindrical surface of the threaded distal protrusion 160 of the housing 102.As depicted in FIG.", "3 and with reference to FIGS.", "4A-6, the sleeve 130 is then secured in place by the anchor mount 131 being threaded or otherwise secured on the distal protrusion 160 of the housing 102 such that the inner annular ring 146 is sandwiched between a proximal end of the anchor mount and the distal end of the housing 102.In some embodiments, the compressible radiopaque (or at least partially radiopaque) fixation sleeve 130 will have configurations different than that depicted in FIGS.", "3-6, but will still employ an inner annular ring 146 that is sandwiched between the anchor mount 131 and the housing 102 for securing the sleeve 130 to the housing 102.For example and as discussed in detail below, the sleeve 130 may have a bellows configuration (see FIGS.", "7A-7D), a tubular configuration (see FIGS.", "8A and 8B), a slit tubular configuration (see FIGS.", "9A and 9B), and a tine configuration (see FIGS.", "10A and 10B).", "Each of the configurations will now be discussed in turn.", "FIGS.", "7A-7D illustrate the bellows sleeve 130, wherein FIGS.", "7A and 7B are, respectively, a side elevation and a cross-sectional elevation of the bellows radiopaque (or at least partially radiopaque) compressible fixation sleeve in a non-compressed state (i.e., its biased state) about an anchor mount 131 and its anchor 66, and FIGS.", "7C and 7D are, respectively, the same views, except showing the bellows sleeve 130 in a compressed state about the anchor mount 131 and its anchor 66.As can be understood from FIGS.", "7A and 7B, the sidewall of the bellows sleeve 130 extends in a serpentine fashion between the proximal face 132 and the distal face 134 of the sleeve 130.The wall structure of the sleeve 130 includes a cylindrical section 170 extending distally from the proximal face 132 to the proximal boundary of a bellows structure 171 of the sleeve 130.Although not illustrated in FIGS.", "7A-7D, in one embodiment, the inner annular ring 146 discussed above with respect to FIGS.", "4A and 4B may be similarly locate in the cylindrical section 170 of the bellows sleeve 130 depicted in FIGS.", "7A-7D for purposes of securing the bellows sleeve 130 to the housing 102 of the leadless pulse generator in a manner as discussed with respect to FIGS.", "3-6 above.", "Referring to FIGS.", "7A and 7B and continuing proximal to distal along the bellows structure 171 from the cylindrical section 170, the bellows structure 171 proximally begins with a first arcuate radially outward projecting and circumferentially extending ridge 172.The first ridge 172 transitions into an arcuate radially inward projecting and circumferentially extending valley 174.The valley 174 transitions into a second arcuate radially outward projecting and circumferentially extending ridge 176 that transitions into a distal ringed terminus 178 of the sleeve 130, the distal edge of the distal ringed terminus 178 of the sleeve 130 forming the distal face 134 of the sleeve 130.The distal ringed terminus 178 may have a circular cross-section, In one embodiment, the distal ringed terminus 178 may be made of a radiopaque pliable polymer material or be a radiopaque ring imbedded in the pliable polymer material forming the rest of the sleeve 130 When the bellows sleeve 130 is compressed from the non-compressed state of FIGS.", "7A and 7B to the compressed state of FIGS.", "7C and 7D, the bellows structure 171 compresses proximal-distal, its first and second ridges 172, 176 abutting together on account of the valley 174 having collapsed radially inward and proximal-distal.", "Thus, while the helical anchor 66 is hidden within the circumferential confines of the bellows sleeve 130 when the sleeve 130 is in the non-compressed state depicted in FIGS.", "7A and 7B, a distal region of the helical anchor 66 is exposed when the sleeve 130 is in the compressed state depicted in FIGS.", "7C and 7D on account of the distal face 134 having been compressed proximally closer to the proximal face 132.FIGS.", "8A and 8B illustrate the tubular sleeve 130, wherein FIG.", "8A is a side elevation of a tubular radiopaque (or at least partially radiopaque) compressible fixation sleeve in a non-compressed state (i.e., its biased state) about an anchor mount 131 and its anchor 66, and FIG.", "8B is the same view, except showing the tubular sleeve 130 in a compressed state about the anchor mount 131 and its anchor 66.As can be understood from FIG.", "8A, the sidewall of the tubular sleeve 130 extends in a generally tubular or cylindrical fashion moving distally from the proximal face 132 until the wall structure of the sleeve radially flairs outward in a generally conical fashion a distal third of the sleeve 130 distally ending at the distal face 134 of the sleeve 130.Thus, the wall structure of the sleeve 130 includes a proximal cylindrical section 170 extending distally from the proximal face 132 to the proximal boundary of a distal conical section 140 of the sleeve 130.The distal conical section 140 distally transitions into a distal ringed terminus 178 of the sleeve 130.The distal edge of the distal ringed terminus 178 of the sleeve 130 forms the distal face 134 of the sleeve 130.The distal ringed terminus 178 may have a circular cross-section.", "Although not illustrated in FIGS.", "8A and 8B, in one embodiment, the inner annular ring 146 discussed above with respect to FIGS.", "4A and 4B may be similarly locate in the cylindrical section 170 of the tubular sleeve 130 depicted in FIGS.", "8A and 8B for purposes of securing the tubular sleeve 130 to the housing 102 of the leadless pulse generator in a manner as discussed with respect to FIGS.", "3-6 above.", "When the tubular sleeve 130 is compressed from the non-compressed state of FIG.", "8A to the compressed state of FIG.", "8B, the distal conical section 140 proximally folds back on itself and radially outwardly expands in diameter.", "Thus, while the helical anchor 66 is hidden within the circumferential confines of the tubular sleeve 130 when the sleeve 130 is in the non-compressed state depicted in FIG.", "8A, a distal region of the helical anchor 66 is exposed when the sleeve 130 is in the compressed state depicted in FIG.", "8B on account of the distal face 134 having been compressed proximally closer to the proximal face 132.As can be understood from a comparison of FIGS.", "8A and 8B, the sleeve 130 is configured such that, in the course of the helical anchor 66 screwing into the cardiac tissue and the distal face 134 being forced against the cardiac tissue, thereby transitioning the sleeve 130 from its biased state (FIG.", "8A) to its deflected state (FIG.", "8B), the distal section 140 folds proximally and the distal face 134 increases in diameter.", "Also, the distal face 134 changes from facing distally to facing radially outward when the distal face 134 displaces proximally towards the proximal face 132.FIGS.", "9A and 9B illustrate the slit tubular sleeve 130, wherein FIG.", "9A is a side elevation of a slit tubular radiopaque (or at least partially radiopaque) compressible fixation sleeve in a non-compressed state (i.e., its biased state) about an anchor mount 131 and its anchor 66, and FIG.", "9B is the same view, except showing the slit tubular sleeve 130 in a compressed state about the anchor mount 131 and its anchor 66.As can be understood from a comparison of the tubular embodiment depicted in FIGS.", "8A and 8B to the slit tubular embodiment of FIGS.", "9A and 9B, the two embodiments are substantially similar, except the distal conical region 140 of the slit tubular embodiment of FIGS.", "9A and 9B includes a series of relatively narrow gaps 200 defined in the distal conical section 140 of the slit tubular embodiment of FIGS.", "9A and 9B.", "Specifically, the distal conical section 140 of the slit tubular embodiment of FIGS.", "9A and 9B includes a series of longitudinally extending slits or slots 200 extending the length of the distal conical section 140, and these slits 200 are evenly distributed about the circumference of the distal conical section 140.The slits 200 may be rectangular shaped or any other shape.", "The slits 200 define a series of longitudinally extending readily pliable members 202 that are evenly distributed about the circumference of the distal conical section 140.The members 202 may be rectangular shaped or any other shape.", "Although not illustrated in FIGS.", "9A and 9B, in one embodiment, the inner annular ring 146 discussed above with respect to FIGS.", "4A and 4B may be similarly locate in the cylindrical section 170 of the slit tubular sleeve 130 depicted in FIGS.", "9A and 9B for purposes of securing the slit tubular sleeve 130 to the housing 102 of the leadless pulse generator in a manner as discussed with respect to FIGS.", "3-6 above.", "When the slit tubular sleeve 130 is compressed from the non-compressed state of FIG.", "9A to the compressed state of FIG.", "9B, the members 202 of the distal conical section 140 proximally fold back on themselves and radially outwardly splay in an increased diameter.", "Thus, while the helical anchor 66 is hidden within the circumferential confines of the slit tubular sleeve 130 when the sleeve 130 is in the non-compressed state depicted in FIG.", "9A, a distal region of the helical anchor 66 is exposed when the sleeve 130 is in the compressed state depicted in FIG.", "9B on account of the distal face 134 having been compressed proximally closer to the proximal face 132.As can be understood from a comparison of FIGS.", "9A and 9B, the sleeve 130 is configured such that, in the course of the helical anchor 66 screwing into the cardiac tissue and the distal face 134 being forced against the cardiac tissue, thereby transitioning the sleeve 130 from its biased state (FIG.", "9A) to its deflected state (FIG.", "9B), the distal section 140 folds proximally and the distal face 134 increases in diameter.", "Also, the distal face 134 changes from facing distally to facing radially outward when the distal face 134 displaces proximally towards the proximal face 132, Further, the members 202 change from projecting distally to projecting radially outward when the distal face 134 displaces proximally towards the proximal face 132.As can be understood from a comparison of the slit tubular embodiment depicted in FIGS.", "9A and 9B to the tined tubular embodiment of FIGS.", "10A and 10B, the two embodiments are substantially similar, except the slit tubular embodiment of FIGS.", "9A and 9B includes a series of relatively narrow gaps 200 and a series of relatively wide members 202 while the tined tubular embodiment includes a series of relatively wide gaps 200 and a series of relatively narrow pliable members 202 that may be considered pliable fines 202.Specifically, the distal conical section 140 of the tined tubular embodiment of FIGS.", "10A and 10B includes a series of longitudinally extending slits or slots 200 extending the length of the distal conical section 140, and these slits 200 are evenly distributed about the circumference of the distal conical section 140.The slits 200 may be rectangular shaped or any other shape.", "The slits 200 define a series of longitudinally extending readily pliable members or tines 202 that are evenly distributed about the circumference of the distal conical section 140.The members 202 may be rectangular shaped or any other shape.", "Although not illustrated in FIGS.", "10A and 10B, in one embodiment, the inner annular ring 146 discussed above with respect to FIGS.", "4A and 4B may be similarly locate in the cylindrical section 170 of the tined tubular sleeve 130 depicted in FIGS.", "10A and 10B for purposes of securing the tined tubular sleeve 130 to the housing 102 of the leadless pulse generator in a manner as discussed with respect to FIGS.", "3-6 above.", "When the tined tubular sleeve 130 is compressed from the non-compressed state (i.e., its biased state) of FIG.", "10A to the compressed state of FIG.", "10B, the members or tines 202 of the distal conical section 140 proximally fold back on themselves and radially outwardly splay in an increased diameter.", "Thus, while the helical anchor 66 is hidden within the circumferential confines of the tined tubular sleeve 130 when the sleeve 130 is in the non-compressed state depicted in FIG.", "10A, a distal region of the helical anchor 66 is exposed when the sleeve 130 is in the compressed state depicted in FIG.", "10B on account of the distal face 134 having been compressed proximally closer to the proximal face 132.As can be understood from a comparison of FIGS.", "10A and 10B, the sleeve 130 is configured such that, in the course of the helical anchor 66 screwing into the cardiac tissue and the distal face 134 being forced against the cardiac tissue, thereby transitioning the sleeve 130 from its biased state (FIG.", "10A) to its deflected state (FIG.", "10B), the distal section 140 folds proximally and the distal face 134 increases in diameter.", "Also, the distal face 134 changes from facing distally to facing radially outward when the distal face 134 displaces proximally towards the proximal face 132.Further, the members 202 change from projecting distally to projecting radially outward when the distal face 134 displaces proximally towards the proximal face 132.The following discussion pertains to a delivery method for implanting a leadless pulse generator 120 equipped with a fixation sleeve 130 such as any of those disclosed herein.", "The method begins with the leadless pulse generator 120 being tracked via delivery tools (e.g., a delivery catheter, etc.)", "through the patient vasculature to an implantation site in the patient's heart.", "Upon the distal end of the leadless pulse generator being placed against the implantation site, gentle forward pressure is applied on the delivery catheter until noticing a slight movement of the delivery catheter proximal to the leadless pulse generator and synchronous to the heartbeat.", "The curve of the catheter down to the inferior vena cave is visualized via fluoroscopy.", "The implant site and the distal region of the delivery tool(s), plus the leadless pulse generator 120 and its fixation sleeve 130, are visualized via fluoroscopy while the leadless pulse generator 120 is caused to rotate clockwise as the radiopaque marker 124 of the leadless pulse generator is observed, its turns being counted for the appropriate number of turns to cause the helical anchor 66 to screw fully into the cardiac tissue.", "Simultaneously, the distal face 134 of the radiopaque fixation sleeve 130 and the helical anchor 66 are observed via fluoroscopy, including the positional relationship of the distal face 134 of the sleeve 130 relative to the anchor 66.While visualizing the radiopaque fixation sleeve during the rotation of the leadless pulse generator 120, if the distal tip electrode 112 remains proximal to the distal face 134 of the fixation sleeve 130, the implanter can safely continue rotating the leadless pulse generator until alignment is observed.", "Once the helical anchor 66 is adequately imbedded in the cardiac tissue, as can be understood from the relationship of the distal face 134 of the fixation sleeve 130 relative to the distal tip electrode 112 and/or the helical anchor 66, the implanter can uncouple the leadless pulse generator 120 from the delivery tool(s) with confidence that the leadless pulse generator 120 is securely anchored to the engaged cardiac tissue.", "As noted above, the fixation sleeve equipped leadless pulse generator 120 disclosed herein is advantageous for a number of reasons.", "First, the protective sleeve 130 prevents helical anchor engagement or deformation due to inadvertent snagging of cardiac tissue.", "Second, the compressible sleeve 130 allows fluoroscopic evaluation of distance between cardiac tissue and the distal end electrode 112, thereby conveying information to the implanter regarding whether or not the anchor 66 is properly screwing into cardiac tissue and to what extent.", "Third, the compressible sleeve 130 provides resistance against over-rotation of the leadless pulse generator during implant.", "Fourth, the compressible sleeve 130 provides additional contact surface area to reduce contact pressure and mitigate tissue damage.", "Fifth, the compressible sleeve forms a seal against the endocardium to reduce the possibility of effusion through any potential microperforation created by the helical anchor 66 extending through the thin myocardium.", "Finally, the compressible sleeve 130 with tines or other radially splaying members 202 can act to prevent anti-rotation of an implanted leadless pulse generator 120.The foregoing merely illustrates the principles of the invention.", "Various modifications and alterations to the described embodiments will be apparent to those skilled in the art in view of the teachings herein.", "It will thus be appreciated that those skilled in the art will be able to devise numerous systems, arrangements and methods which, although not explicitly shown or described herein, embody the principles of the invention and are thus within the spirit and scope of the present invention.", "From the above description and drawings, it will be understood by those of ordinary skill in the art that the particular embodiments shown and described are for purposes of illustrations only and are not intended to limit the scope of the present invention.", "References to details of particular embodiments are not intended to limit the scope of the invention." ] ]
Patent_15872616
[ [ "LOOFAH", "A loofah includes an inner core and an outer portion.", "The inner core includes a natural material.", "The outer portion includes a natural material.", "A water absorbency of the inner core is less than a water absorbency of the outer portion." ], [ "1.A loofah, comprising: an inner core including a natural material; and an outer portion including scoured cotton, a water absorbency of the inner core being less than a water absorbency of the outer portion.", "2.The loofah of claim 1, wherein the inner core includes hydro entangled or needled cotton.", "3.The loofah of claim 1, wherein the inner core includes cotton with at least half of its natural oils.", "4.The loofah of claim 1, wherein the inner core includes unbleached cotton.", "5.The loofah of claim 4, wherein the outer portion includes bleached cotton.", "6.The loofah of claim 1, wherein the outer portion includes hydro entangled or needled cotton.", "7.The loofah of claim 1, wherein the outer portion includes bleached cotton.", "8.A loofah, comprising: a first layer, a majority of a material of the first outer layer being scoured cotton; a second layer, a majority of a material of the second outer layer being scoured cotton; and an inner layer disposed between the first layer and the second layer, a majority of a material of the inner layer being a natural material, wherein a water absorbency of the material of the inner layer is less than a water absorbency of the material of the first outer layer, and the water absorbency of the material of the inner layer is less than a water absorbency of the material of the second outer layer.", "9.The loofah of claim 8, wherein the inner layer includes cotton that has at least half of its natural oils.", "10.The loofah of claim 8, wherein the material of the first layer is hydrophilic.", "11.The loofah of claim 8, wherein the material of the inner layer is hydrophobic.", "12.The loofah of claim 8, wherein the material of the inner layer includes unbleached cotton.", "13.The loofah of claim 8, wherein the material of the first layer includes bleached cotton.", "14.The loofah of claim 8, wherein the material of the second layer includes bleached cotton.", "15.The loofah of claim 8, wherein the inner layer includes a stiffening agent.", "16.The loofah of claim 8, further comprising a plurality of beads adhered to the first layer.", "17.The loofah of claim 16, wherein the beads include a puffing agent.", "18.The loofah of claim 8, wherein the material of the first layer is entangled with the material of the second layer.", "19.The loofah of claim 8, wherein the loofah does not include an adhesive.", "20.The loofah of claim 8, wherein the material of the inner layer is exposed at an outer surface of the loofah." ], [ "<SOH> BACKGROUND <EOH>Generally speaking, a loofah is a handheld device used to stimulate and exfoliate human skin, which may be usually used in a shower or bath and may usually be moistened with water and possibly soaps or lotions.", "A loofa is preferably thick enough to have a feeling of body in the hand, especially when wet.", "When wet, it preferably maintains its structural integrity.", "A loofah may be made from materials such as plastics or the body of a type of cucumber intended for repetitive, frequent use.", "A loofah may become soiled with contaminants such as skin dirt, body oils and makeup, after few uses.", "The warm water environment where loofahs are commonly used encourages the growth of molds after a few uses.", "The cost of available full size loofahs ranges from about $5 to $20 each, which leads to a high cost per use if the loofah is discarded due to the above issues.", "Surveys have found that a loofah is used less than five times on average before being discarded.", "In a commercial environment, such as a hotel or spa where a single use is necessary, available loofahs are very expensive on a per use basis.", "A product that allows for uses at a low cost per use would be desirable." ], [ "<SOH> BRIEF SUMMARY <EOH>The present disclosure generally relates to a cotton loofah and, in particular, a cotton exfoliating loofah.", "In an example, a loofah includes an inner core and an outer portion.", "The inner core includes a natural material.", "The outer portion includes a natural material.", "A water absorbency of the inner core is less than a water absorbency of the outer portion.", "In another example, a loofah includes a first outer layer, a second outer layer, and an inner layer.", "A majority of a material of the first outer layer is cotton.", "A majority of a material of the second outer layer is cotton.", "The inner layer is disposed between the first outer layer and the second outer layer.", "A majority of a material of the inner layer is cotton.", "A water absorbency of the material of the inner layer is less than a water absorbency of the material of the first outer layer.", "The water absorbency of the material of the inner layer is less than a water absorbency of the material of the second outer layer.", "In still another example, a method of manufacturing a loofah includes: providing a first sheet of non-woven cotton; depositing unbleached cotton onto the first sheet of non-woven cotton; providing a second sheet of non-woven cotton at a side of the unbleached cotton distal to the first sheet of non-woven cotton; and entangling the first sheet of non-woven cotton, the unbleached cotton, and the second sheet of non-woven cotton." ], [ "CROSS-REFERENCE TO RELATED APPLICATION This application is a continuation application of application Ser.", "No.", "15/369,634 filed on Dec. 5, 2016, which claims priority to U.S.", "Provisional Application No.", "62/262,797, filed on Dec. 3, 2015, the disclosure of which is incorporated herein by its entirety.", "BACKGROUND Generally speaking, a loofah is a handheld device used to stimulate and exfoliate human skin, which may be usually used in a shower or bath and may usually be moistened with water and possibly soaps or lotions.", "A loofa is preferably thick enough to have a feeling of body in the hand, especially when wet.", "When wet, it preferably maintains its structural integrity.", "A loofah may be made from materials such as plastics or the body of a type of cucumber intended for repetitive, frequent use.", "A loofah may become soiled with contaminants such as skin dirt, body oils and makeup, after few uses.", "The warm water environment where loofahs are commonly used encourages the growth of molds after a few uses.", "The cost of available full size loofahs ranges from about $5 to $20 each, which leads to a high cost per use if the loofah is discarded due to the above issues.", "Surveys have found that a loofah is used less than five times on average before being discarded.", "In a commercial environment, such as a hotel or spa where a single use is necessary, available loofahs are very expensive on a per use basis.", "A product that allows for uses at a low cost per use would be desirable.", "BRIEF SUMMARY The present disclosure generally relates to a cotton loofah and, in particular, a cotton exfoliating loofah.", "In an example, a loofah includes an inner core and an outer portion.", "The inner core includes a natural material.", "The outer portion includes a natural material.", "A water absorbency of the inner core is less than a water absorbency of the outer portion.", "In another example, a loofah includes a first outer layer, a second outer layer, and an inner layer.", "A majority of a material of the first outer layer is cotton.", "A majority of a material of the second outer layer is cotton.", "The inner layer is disposed between the first outer layer and the second outer layer.", "A majority of a material of the inner layer is cotton.", "A water absorbency of the material of the inner layer is less than a water absorbency of the material of the first outer layer.", "The water absorbency of the material of the inner layer is less than a water absorbency of the material of the second outer layer.", "In still another example, a method of manufacturing a loofah includes: providing a first sheet of non-woven cotton; depositing unbleached cotton onto the first sheet of non-woven cotton; providing a second sheet of non-woven cotton at a side of the unbleached cotton distal to the first sheet of non-woven cotton; and entangling the first sheet of non-woven cotton, the unbleached cotton, and the second sheet of non-woven cotton.", "BRIEF DESCRIPTION OF THE DRAWINGS Reference is now made to the following descriptions taken in conjunction with the accompanying drawings.", "FIG.", "1 is a perspective view of an exemplary loofah.", "FIG.", "2 is a side view of an exemplary loofah.", "FIG.", "3 is a cross-sectional view of an exemplary loofah.", "FIG.", "4 is a schematic diagram of a manufacturing process of an exemplary loofah.", "DETAILED DESCRIPTION Various embodiments of a loofah are described according to the present disclosure.", "It is to be understood, however, that the following explanation is merely exemplary in describing the devices and methods of the present disclosure.", "Accordingly, several modifications, changes, and substitutions are contemplated.", "For example, although the present disclosure mainly describes a cotton loofah, the disclosed principals may be applied to other personal wipe products.", "Other materials, both natural and processed, may also be used.", "Known natural loofah products are derived from vegetable gourds of the cucumber family.", "E. Bottone, Loofah Sponges are Reservoirs and Vehicles in the Transmission of Potentially Pathogenic Bacterial Species to the Human Skin, Journal of Clinical Microbiology, February 1994, p. 469.The hydration of dry loofah sponges even with sterile distilled water liberates bacteria embedded in the fibrous matrix of the loofah sponge.", "Bottone at 471.Bottone found a number of harmful bacteria in the natural loofah sponge promoted by the manufacturing process of the loofah sponges, which as soaked in water for several days to move the gourd skin and seeds.", "Id.", "The present inventor has discovered that cotton, when prepared according to the present disclosure, can be used to create a loofah type product with a good feel and performance that does not suffer from the bacteriological deficiencies described above that arise from the fibrous matrix of a vegetable gourd.", "Also, when the disclosed loofah type product is used as a single use product, the opportunity to incubate bacteria is limited or avoided.", "FIG.", "1 is a perspective view of an exemplary cotton loofah.", "FIG.", "2 is a side view of an exemplary cotton loofah.", "FIG.", "3 is a cross-sectional view of an exemplary cotton loofah.", "Referring to FIGS.", "1-3, the exemplary cotton loofah 10 includes a first outer layer 12, an intermediate layer 14 and a second outer layer 16.Each of the layers 12, 14 and 16 are preferably 100% cotton or a mostly cotton process.", "The use of 100% or mostly cotton for the exterior and interior of a personal wipe is preferable.", "Today's consumer of beauty care products is sensitive to the life cycle of products.", "They wish to know that the product comes from a renewable source, and the “harvesting” of this source is “kind” to the environment.", "The processing of cotton product used in the loofah 10 may be minimal and not requiring or adding harmful ingredients to the cotton.", "The product looks and “feels” natural and luxurious, and simply and effectively works for their use.", "The disposal of a cotton based product may also be environmentally “friendly” in the consumer's eyes.", "It will be appreciated that while this discussion s provided in the context of a loofah type product, the disclosure is not limited to a loofah.", "For example, there are other applications where a disposable high quality alternative personal wipe is desirable.", "For example, in the removal of a treatment mask such as a clay mask, a cloth may typically be used as a disposable wipe has not previously had the hand feel, size, robustness, surface abrasion (ability to grab and hold the mask chemistry).", "The cloth then must be laundered or discarded.", "The removal of makeup is made easier with the disclosed cotton product compared to more flimsy light wipes while also being more economical than cloths/towels that are high cost and/or need to be laundered.", "The use of 100% or mostly cotton for the exterior and interior of a personal wipe is highly desirable.", "Today's consumer of beauty care products is sensitive to the life cycle of products.", "They wish to know that the product comes from a renewable source, and the “harvesting” of this source is “kind” to the environment.", "The processing of this product is minimal and does not add harmful ingredients.", "The product looks and “feels” natural and luxurious, and simply and effectively works for their use.", "The disposal needs to be environmentally “friendly” in their eyes.", "There is a need for a product that allows for uses at a low cost per use.", "This is particularly advantageous in applications where a single or minimal number of uses are expected.", "Preferably, the loofah holds moisture and maintains integrity when wet.", "As an example, a 100% or mostly cotton product may be made using a needling or hydro entangled process that preferably has a total weight between 5 to 10 oz/sy.", "The first outer layer 12 and the second outer layer 16 (e.g., outer exfoliating layer(s)) may be made of grade of cotton that is cleaned, scoured (for example, using a solution containing sodium hydroxide), and in some cases may also be bleached.", "After scouring, the cotton fiber is absorbent and cleaned.", "The degree of absorbency of the cotton fiber may vary after it has been processed (e.g., cleaned, scoured or bleached).", "That it has some absorbency means that it is a hydrophilic-type material.", "Cotton, particularly processed cotton, has a natural affinity for oil making it particularly advantageous when provided as an outer surface of a personal wipe such as the cotton loofah 10 as it may be very effective as a skin oil blotter.", "The scoured cotton may then be manufactured into a non-woven material, for example by hydroentanglement.", "The first layer 12 and 16 may be provided as non-woven sheet material that is thin and lightweight, for example, 1 oz/sy respectively.", "It will be appreciated that the cotton fibers of the first outer layer 12 and the second outer layer 16 are not required to be pre-manufactured in a non-woven material and may also be provided in a bulk form.", "The intermediate layer 14 is preferably less absorptive than the first outer layer 12 and the second outer layer 16.The bleaching and cleaning process described above with respect to the first outer layer 12 and the second outer layer 16 removes the natural oils of the cotton.", "An example of the material (which may be referred to as a core material) for the intermediate layer 14 is unbleached, or unprocessed, or raw cotton.", "A core material (e.g., cotton) that has not had its natural oils removed has a coating of natural waxes that protect it from rain, which ultimately makes it a hydrophobic-type product (water repellent).", "This means raw cotton is usually unsuitable for use in many consumer products that require absorbency, a trait that is considered critical in most cotton applications.", "Raw cotton absorbs less water than had the natural oils been removed.", "For example, the core material may be hydrophobic (e.g., would not adsorb water).", "Raw cotton has the additional advantage that it is less expensive than processed cotton, making the loofah 10 more economical.", "The core material may be provided as bulk, hydroentangled or needled cotton, may have a weight of 3 to 6 oz/sy, and may be made from a grade of cotton that has not had its natural oils removed.", "The inventor has discovered that raw cotton, which had generally been considered undesirable for a personal wipe product, works particularly well for the inner portion of loofah type product.", "This may allow the assembled cotton loofah 10 to have an absorbent surface (for example, to hold cleaners or absorb materials being removed from a face like makeup or a mask) yet not absorb large amounts of water.", "This may provide a product that does not “ball up” when soaked with water.", "An exemplary additional advantage is that unprocessed cotton is lower in cost as well as more “natural.” Thus, the assembled cotton loofah 10 may be much less expensive to produce as well as having a lower environmental impact though the reduced use of caustic chemicals.", "The savings in cost by using raw cotton for the intermediate layer 14 is significant as, preferably, 50-75% of the cotton by weight in the loofah 10 is the core material.", "The cost to the consumer for the assembled cotton loofah 10 may be a small fraction of the cost of available alternatives.", "The first outer layer 12, the intermediate layer 14 and the second outer layer 16 of the loofah 10 may be coupled together by a needling or hydro entangling process, which may provide an efficient method of incorporating the exfoliating layers(s) (e.g., the first outer layer 12 and the second outer layer 16 discussed in more detail below) with the core cotton product (e.g., the intermediate layer 14) while not requiring adhesives or bonding agents.", "The combination of bonding the exfoliating layer(s) while needling or hydro entangling the core cotton product may also provide significant economy.", "In an embodiment, the material of the intermediate layer 14 may be treated with a binder agent, which may stiffen the intermediate layer.", "An example of a stiffening binder agent is Dur-O-Set® C-310 Emulsion made by Celanese Corporation.", "It is a water-based polyvinyl acetate emulsion that imparts rigidity and stiffness.", "Another example of a stiffening binder agent is Resyn®1601 Emulsion made by Celanese Corporation.", "It is a water-based polyvinyl acetate emulsion stabilized with polyvinyl alcohol that will also impart rigidity and stiffness.", "The inventor has discovered that stiffening the intermediate layer 14 is particularly advantageous for a loofah-type product as it may approximate the stiffer feel of the natural gourd type loofah or the synthetic material loofah while retaining the softer cotton touch on the skin of the consumer.", "The binder may also increase the hydrophobic properties of the core material.", "This combination of an overall stiffer loofah 10 while retaining a softer outer surface provides an experience that the inventor has determined to be more preferred by the consumer.", "In an embodiment, one or two surfaces of the loofah 10 may have an outer surface that includes exfoliating materials or exfoliating properties.", "For example, the first outer layer 12 and/or the second outer layer 16 may include a textured cotton material provided by applying a patterned coating to the sheet.", "The patterned coating may include the beads 20 adhered to the outer surface of the first outer layer 12 and/or the second outer layer 16.Each bead 20 is formed to have a three dimensional geometry that extends outwardly from the surface of the outer layer.", "The beads may improve the abrasive qualities of the loofah 10.This may offer advantages such as improved scrubbing performance of the loofah.", "As will be discussed further below, the beads may be made of materials that are not as water soluble as the first outer layer 12 and the second outer layer 16.Thus, the performance of the loofah while wet may be further improved.", "It will be appreciated that the term “bead” is not limiting and refers to a variety of different protrusions.", "The beads 20 may also include materials including abrasive particles and/or acrylic resin(s).", "An example of an exfoliating agent is abrasive particles included in the coating that can provide a selectively abrasive surface.", "The specific type, size, and density of abrasive particles within the coating can be varied to suit the application at hand.", "In a preferred example, each bead 20 includes a puffing agent.", "The composition that forms the bead 20 may also include an appropriate binding agent such as an acrylic emulsion that enhances the adherence of the composition, including the puffing agent, to the cotton wipe sheet 12.When a puffing agent is exposed to an elevated temperature (e.g., elevated over ambient) it expands (for example, by releasing a gas) to at least in part create the three dimensional shapes of the beads 20.With reference to the cross-section of FIG.", "3, the puffing agent leads to an air space 22 in an interior portion of the beads 20.While an exfoliating product is desirable, if the beads 20 are too abrasive, the consumer may have a less desirable experience.", "The inventor has determined that the use of a puffing agent in the beads 20 is particularly advantageous as it leads to a more favorable feel to the loofah 10, which, as discussed above, may include a binder to stiffen the intermediate layer 14, the inventor has determined that.", "In a second example, the beads 20 include a thermoplastic material.", "Examples of acceptable thermoplastic plastics include, but are not limited to, one or more of polypropylene (“PP”), polyethylene (“PE”), acrylonitrile butadiene styrene (“ABS”), polyamide (“PA”; also referred to as “Nylon”), polyethylene terephthalate (“PET”), polyvinyl chloride (“PVC”) or copolymers thereof.", "It will be appreciated that the outer surfaces of the first outer layer 12 and the second outer layer 16 may be provided with two different levels of abrasion, for example, by using different abrasive additives in the beads 20 or by differences in the geometry of the beads 20.The degree of abrasion of the outer surfaces of the first outer layer 12 and the second outer layer 16 may be identified by including different colors of the surfaces.", "For example, the beads 20 may be colored or the first outer layer 12 and/or the second outer layer 16 may be died and/or include a printed surface.", "Different levels of abrasion may be useful for facial vs body use.", "In some embodiments (with or without the beads 20), a coating may be applied to the first outer layer 12 and/or the second outer layer 16 that may include one or more of a cleaning agent, a medicinal agent, an exfoliating agent, and a soap material such as a dry soaping agent to provide additional cleaning ability without the need for additional soaps.", "The dry soaping agent is particularly advantageous in the loofah 10 used in a single use context Referring to FIG.", "4, a method of manufacturing a cotton loofah, such as the loofah 10 described above, will be described.", "A manufacturing process 100 includes a roll 112 of nonwoven cotton sheet, which may already include the puffed beads 20 or the puffed beads 20 may be applied thereto.", "The roll 112 of nonwoven cotton becomes the first outer layer 12 of the loofah 10.The core material, for example raw cotton, may be provided by a bale 114.The bale 114 of core material may be opened and fluffed by the machine 120 and then deposited onto the non-woven sheet material of the first outer layer 12.The core material becomes the intermediate layer 14 of the loofah 10.The opened and fluffed material may have a binder applied by the machine 122 before it is deposited on the first outer layer 12.The binder may also be sprayed onto the intermediate layer 14 after it is deposited onto the first outer layer 12.A second roll 116 of nonwoven cotton becomes the second outer layer 16 of the loofah 10.The roll 116 of nonwoven cotton may already include the puffed beads 20 or the puffed beads 20 may be applied thereto.", "It will be appreciated that while two rolls of nonwoven cotton have been depicted, a single two ply roll may be used or as yet another alternative, a wide roll may be cut and the cut portions provided in the place of the two rolls of nonwoven cotton.", "The first outer layer 112, the intermediate layer 114, and the second outer layer 116 may be provided to the needling/hydroentangling machine 124 to adhere the layers together.", "The machine 124 may pull fibers of the first outer layer 112 into the second outer layer 116 and vice versa.", "Bonding the exfoliating layer(s) as part of the needling or hydro entangling process may provide an efficient method of incorporating the exfoliating layers(s) with the cotton product while not requiring adhesives or bonding agents.", "As noted above, the combination of bonding the exfoliating layer(s) while needling or hydro entangling the cotton product may also provide significant economy.", "This method may also provide a way to insure the “purity” of the final product by limiting the ingredients.", "The combined first outer layer 112, intermediate layer 114, and second outer layer 116 may then be provided to a cutter and stacker 126 to provide the finished loofah 10.As an additional advantage of not requiring glues or adhesives and that all the layers of the loofah 10 may be provided from cotton, further processing steps such as providing a stiches edge are not required.", "Thus, the intermediate layer 114 may remain exposed at the edges of the loofah 10.In an embodiment, the loofah 10 is provided as a four sided product, such as a square or rectangle.", "Preferably, the loofah 10 is about the size of a hand having sides in the range of 4-6″.", "A four sided product having sides in the range of 4-6″ can be quickly manufactured using wide format machines making the manufacture of the loofah 10 fast and efficient.", "While other shapes such as round and oval may be used, a four sided shape can be quickly cut and stacked with little waste.", "This may also increase the economy of the finished loofah 10.While various embodiments in accordance with the disclosed principles have been described above, it should be understood that they have been presented by way of example only, and are not limiting.", "For example, the present disclosure is not limited to cotton products and is also applicable to other materials such as rayon, bamboo fiber, tree fiber, grass fiber and synthetic analogs of the same.", "Regenerated cotton products may also be used for some or all of the layers of the disclosed loofah.", "These alternative materials, including rayon and bamboo fiber, can each be prepared to have different water absorbencies for inner core material as compared to an outer material according the principals of the present disclosure.", "It will also be appreciated that the layers of the loofah may include synthetic materials blended with cotton or may also be fully synthetic.", "For example, the core may include other less or non-absorptive materials such as synthetic materials like polyester, polypropylene, polyethylene or combinations thereof.", "As another example, the outer layers may include a blend (e.g., 10%) polyester, polyethylene, or combinations thereof for lower cost.", "Thus, the breadth and scope of the invention(s) should not be limited by any of the above-described exemplary embodiments, but should be defined only in accordance with the claims and their equivalents issuing from this disclosure.", "Furthermore, the above advantages and features are provided in described embodiments, but shall not limit the application of such issued claims to processes and structures accomplishing any or all of the above advantages." ] ]
Patent_15872618
[ [ "APPARATUS AND METHOD FOR SECURE PROVISIONING OF A COMMUNICATION DEVICE", "A system that incorporates the subject disclosure may perform, for example, obtaining programming data via an over-the-air programming message for use by a communication device, wherein the over-the-air programming message is obtained from, and encrypted by an over-the-air programming server.", "The over-the-air programming message is decrypted utilizing a first keyset obtained by a secure device processor processing the first keyset obtained from a remote management server via transmission by the over-the-air programming server, to generate a first-key decrypted over-the-air programming message.", "The decrypted over-the-air programming message is provided to a secure element to enable the secure element to further decrypt the first-key decrypted over-the-air programming message utilizing a second keyset, wherein the secure device processor does not have access to the second keyset.", "Other embodiments are disclosed." ], [ "1.A method comprising: obtaining, by a secure processing device of a communication device, an over-the-air programming message that includes programming data, wherein the programming data is for use by the communication device, wherein the secure processing device includes a processor, and wherein the over-the-air programming message is obtained from an over-the-air programming server; decrypting, by the secure processing device, the over-the-air programming message utilizing a first keyset obtained by the secure processing device to generate a first-keyset decrypted over-the-air programming message, wherein the first keyset is obtained from a remote management server via transmission by the over-the-air programming server; and providing, by the secure processing device, the first-keyset decrypted over-the-air programming message to a secure element, wherein the providing of the first-keyset decrypted over-the-air programming message to the secure element enables the secure element to further decrypt the first-keyset decrypted over-the-air programming message utilizing a second keyset, and wherein the secure processing device does not have access to the second keyset.", "2.The method of claim 1, further comprising: determining, by the secure processing device, a schedule for providing messages to the secure element of the communication device, wherein the secure processing device is separate from the secure element and in communication with the secure element.", "3.The method of claim 1, wherein the over-the-air programming message originates from a service provisioning system, wherein the over-the-air programming server does not have access to the second keyset, and wherein the service provisioning system has access to the second keyset.", "4.The method of claim 3, comprising: determining, by the secure processing device, that a response has been generated by the secure element and is associated with the over-the-air programming message; and providing, by the secure processing device, the response to the over-the-air programming server for transmission to the service provisioning system, wherein the response is encrypted by the secure element utilizing the second keyset, and wherein the response is configured for decryption by the service provisioning system utilizing the second keyset.", "5.The method of claim 1, further comprising: monitoring, by the secure processing device, for a response provided by the secure element; determining, by the secure processing device, that the response is associated with the over-the-air programming message; encrypting, by the secure processing device, the response utilizing the first keyset to generate an encrypted response; and providing, by the secure processing device, the encrypted response to the over-the-air programming server to enable the over-the-air programming server to decrypt the encrypted response for transmission to a service provisioning system.", "6.The method of claim 5, further comprising: authenticating, by the secure processing device, with the secure element utilizing a third keyset; and obtaining, by the secure processing device, the first keyset from the secure element, wherein the first keyset is generated by the secure element from a static key that is provided by the remote management server to the secure element and to the over-the-air programming server.", "7.The method of claim 6, wherein the providing of the static key to the secure element by the remote management server is based on another over-the-air programming message that utilizes short message service transport protocol.", "8.The method of claim 1, comprising: providing, by the secure processing device, a request to the secure element for the first keyset responsive to a determination that the over-the-air programming message has been encrypted; and obtaining, by the secure processing device, the first keyset from the secure element.", "9.The method of claim 1, comprising retransmitting, by the secure processing device, the first-keyset decrypted over-the-air programming message to the secure element.", "10.A method comprising: generating, by a processing system of a server, a first keyset from a static key obtained from a remote management server via a secure element of a communication device, wherein the processing system includes a processor, and wherein the secure element generates a first keyset from the static key to enable the secure element to provide the first keyset to a secure device processor of the communication device; encrypting, by the processing system of the server, an over-the-air programming message utilizing the first keyset to generate an encrypted over-the-air programming message, wherein the over-the-air programming message includes programming data for use by the communication device; and providing, by the processing system of the server, the encrypted over-the-air programming message to the secure device processor of the communication device to enable the secure device processor to decrypt the encrypted over-the-air programming message utilizing the first keyset, wherein the providing of the encrypted over-the-air programming message further enables the secure device processor to provide the programming data to the secure element of the communication device for provisioning of the communication device, wherein the secure device processor is separate from the secure element and in communication with the secure element, wherein the providing of the programming data to the secure element enables the secure element to further decrypt the programming data utilizing a second keyset, and wherein the secure device processor does not have access to the second keyset.", "11.The method of claim 10, comprising obtaining, by the processing system of the server, the over-the-air programming message from a service provisioning system, wherein the over-the-air programming message is encrypted by the service provisioning system utilizing a second keyset.", "12.The method of claim 10, wherein the providing of the encrypted over-the-air programming message to the secure device processor utilizes a hypertext transfer protocol.", "13.The method of claim 10, wherein the secure device processor provide the programming data to the secure element of the communication device according to a schedule for provisioning of the communication device.", "14.The method of claim 13, wherein the schedule is determined by the secure device processor.", "15.The method of claim 10, comprising: obtaining, by the processing system of the server, the over-the-air programming message from a service provisioning system; obtaining, by the processing system, a request from the service provisioning system to provide the over-the-air programming message to a second communication device; determining, by the processing system of the server, that the second communication device is not registered with the server; and providing, by the processing system of the server, a notice to the service provisioning system indicating that a second secure device processor of the second communication device is not registered with the server.", "16.The method of claim 10, comprising: obtaining, by the processing system of the server, a response to the over-the-air programming message; decrypting, by the processing system of the server, the response utilizing the first keyset to generate a first-keyset decrypted response; and providing, by the processing system of the server, the first-keyset decrypted response to a service provisioning system that originated the over-the-air programming message.", "17.A communication device comprising: a secure element having a secure element memory with first executable instructions, wherein the secure element, responsive to executing the first executable instructions, performs first operations comprising: providing a first keyset to a secure device processor; and performing an additional decryption of a first-keyset decrypted over-the-air programming message obtained from the secure device processor, utilizing a second keyset, wherein the secure device processor does not have access to the second keyset; and the secure device processor having a secure device processor memory with second executable instructions, wherein the secure device processor, responsive to executing the second executable instructions, performs second operations comprising: decrypting an over-the-air programming message utilizing the first keyset to generate the first-keyset decrypted over-the-air programming message, wherein the over-the-air programming message includes programming data for provisioning the communication device, wherein the secure device processor is separate from the secure element and in communication with the secure element; and a device processor that facilitates wireless communications of the communication device, wherein the device processor is separate from the secure device processor and the secure element.", "18.The communication device of claim 17, wherein the first operations further comprise: obtaining a static key via a remote management server, wherein the remote management server provides the static key to an over-the-air programming server that provides the over-the-air programming message to the secure device processor; and generating the first keyset from the static key.", "19.The communication device of claim 17, wherein the secure element comprises a universal integrated circuit card, and wherein the over-the-air programming message utilizes a hypertext transfer protocol.", "20.The communication device of claim 17, wherein the first operations further comprise: generating a secure message for transmission; encrypting the secure message utilizing the second keyset to generate an encrypted secure message; and providing the encrypted secure message to the secure device processor for transmission to a destination device via an intermediate server to enable the destination device to decrypt the encrypted secure message utilizing the second keyset, wherein the encrypted secure message is further encrypted by the secure device processor utilizing the first keyset to obtain a twice encrypted secure message, and wherein the twice encrypted secure message is further decrypted by the intermediate server utilizing the first keyset prior to delivery to the intermediate server." ], [ "<SOH> BACKGROUND <EOH>Electronic devices are being utilized with more frequency to conduct various types of transactions and exchanges of information.", "The electronic devices can be provisioned with programming data, including an initial provisioning and subsequent provisioning(s).", "The provisioning can sometimes include receiving the programming data from a remote source." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>Reference will now be made to the accompanying drawings, which are not necessarily drawn to scale, and wherein: FIG.", "1 depicts an illustrative embodiment of a system that enables use of a UICC and a secure device processor as part of a secure services platform for a securely provisioning a communication device; FIG.", "2 depicts an illustrative embodiment of a system including the communication device of FIG.", "1 implementing authentication and management functions, as well as provisioning functions; FIGS.", "3A-3B depict an illustrative embodiment of a system that can be used for securely providing over-the-air programming of a communication device; FIGS.", "4A-4B depict an illustrative embodiment of a system that can be used for provisioning devices that are engaged in securely providing over-the-air programming of a communication device; FIGS.", "5A-5B depict an illustrative embodiment of a system that can be used for providing secure over-the-air programming of a communication device; FIG.", "6 depicts an illustrative embodiment of a method used in portions of the systems described in FIGS.", "1-5B ; FIG.", "7 depicts an illustrative embodiment of a communication system that provides media services including secure communication of over-the-air programming for a communication device; FIG.", "8 depicts an illustrative embodiment of a communication device that can securely communicate messages and responses related to over-the-air programming; and FIG.", "9 is a diagrammatic representation of a machine in the form of a computer system within which a set of instructions, when executed, may cause the machine to perform any one or more of the methods described herein.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a Continuation of and claims priority to U.S. patent application Ser.", "No.", "15/056,441, filed on Feb. 29, 2016, which is a Continuation of and claims priority to U.S. patent application Ser.", "No.", "14/070,458 filed Nov. 1, 2013, issued as U.S. Pat.", "No.", "9,313,660.The contents of each of the foregoing is/are hereby incorporated by reference into this application as if set forth herein in full.", "FIELD OF THE DISCLOSURE The subject disclosure relates to an apparatus and method for secure provisioning of a communication device.", "BACKGROUND Electronic devices are being utilized with more frequency to conduct various types of transactions and exchanges of information.", "The electronic devices can be provisioned with programming data, including an initial provisioning and subsequent provisioning(s).", "The provisioning can sometimes include receiving the programming data from a remote source.", "BRIEF DESCRIPTION OF THE DRAWINGS Reference will now be made to the accompanying drawings, which are not necessarily drawn to scale, and wherein: FIG.", "1 depicts an illustrative embodiment of a system that enables use of a UICC and a secure device processor as part of a secure services platform for a securely provisioning a communication device; FIG.", "2 depicts an illustrative embodiment of a system including the communication device of FIG.", "1 implementing authentication and management functions, as well as provisioning functions; FIGS.", "3A-3B depict an illustrative embodiment of a system that can be used for securely providing over-the-air programming of a communication device; FIGS.", "4A-4B depict an illustrative embodiment of a system that can be used for provisioning devices that are engaged in securely providing over-the-air programming of a communication device; FIGS.", "5A-5B depict an illustrative embodiment of a system that can be used for providing secure over-the-air programming of a communication device; FIG.", "6 depicts an illustrative embodiment of a method used in portions of the systems described in FIGS.", "1-5B; FIG.", "7 depicts an illustrative embodiment of a communication system that provides media services including secure communication of over-the-air programming for a communication device; FIG.", "8 depicts an illustrative embodiment of a communication device that can securely communicate messages and responses related to over-the-air programming; and FIG.", "9 is a diagrammatic representation of a machine in the form of a computer system within which a set of instructions, when executed, may cause the machine to perform any one or more of the methods described herein.", "DETAILED DESCRIPTION The subject disclosure describes, among other things, illustrative embodiments in which provisioning can be performed for a communication device, such as via Over-The-Air programming (OTA) messages securely delivered to a communication device(s).", "The secure delivery can be performed utilizing authentication and/or encryption based on various keysets that are provided to various combinations of devices and/or components.", "In one embodiment, device-based traffic management for Internet Protocol (IP)-based (e.g., Hypertext Transfer Protocol (HTTP)) can be performed.", "In one embodiment, security mechanisms for HTTP-based OTA can be provided.", "In one embodiment, network and/or device functionality may be managed remotely.", "In one embodiment, support for multiple HTTP-based OTA servers can be provided for securely provisioning one or more communication devices via OTA messaging.", "In one embodiment, a device-based proxy can be utilized to provide traffic management for HTTP-based OTA messages.", "In one embodiment, a device-based proxy and a secure element (e.g., a Universal Integrated Circuit Card (UICC)) can be utilized to provide security for HTTP-based OTA messages, such as through authentication and/or encryption.", "In one embodiment, a Secure Device Processor (SDP) can be utilized as the device-based proxy.", "In one embodiment, remote management of the device and/or network components can be performed.", "In one embodiment, an administrative agent key function is provided that may be located in the UICC.", "In one embodiment, an administrative agent function is loaded into an SDP of a communication device, such as a mobile smart phone.", "In one embodiment, a remote management function can be provided in a remote management server in order to manage (in whole or in part) the administrative agent function, the administrative agent key function, and/or the transport keys that are distributed, such as to the SDP and/or OTA server(s).", "In one or more embodiments, the secure element (e.g., executing the administrative agent key function), the secure device processor (e.g., executing the administrative agent function) and/or the device processor can be separate but in communication with each other.", "The secure element (e.g., UICC) can be a highly secure computing platform for storing secrets such as encryption keys and authentication credentials, and can host and execute applets.", "The SDP can be a processor that is logically and/or physically separate from the device processor (and/or the secure element), and can offer more security than the device processor, but not as much security as the secure element.", "Examples of an SDP include a Trusted Execution Environment (TEE) and an embedded Secure Element (eSE).", "In one or more embodiments, the administrative agent function of the SDP in conjunction with the OTA server can provide a secure means for delivering messages and response associated with OTA, including various programming data, to the secure element to enable the secure element to utilize the programming data (e.g., executing software updates, adjusting configuration settings or parameters and so forth).", "Other embodiments are included in the subject disclosure.", "One embodiment of the subject disclosure is a method including registering, by an administrative agent function operating in a secure device processor of a mobile communication device, an internet protocol address with an over-the-air programming server, where the internet protocol address is associated with the administrative agent function.", "The method can include receiving, from the over-the-air programming server by the administrative agent function, an over-the-air programming message that includes programming data for use by the mobile communication device, where the over-the-air programming message is encrypted by the over-the-air programming server, and where the over-the-air programming message utilizes a hypertext transfer protocol.", "The method can include decrypting, by the administrative agent function, the over-the-air programming message utilizing a first keyset to generate a decrypted over-the-air programming message.", "The method can include determining, by the administrative agent function, a schedule for providing messages to a secure element of the mobile communication device, where the secure device processor is separate from the secure element and in communication with the secure element.", "The method can include providing, by the administrative agent function, the decrypted over-the-air programming message to the secure element according to the schedule.", "One embodiment of the subject disclosure is a method that includes receiving, by a server including a processor, a registration request including an internet protocol address, where the registration request is received from a secure device processor of a mobile communication device.", "The method can include encrypting, by the server, an over-the-air programming message utilizing a first keyset to generate an encrypted over-the-air programming message, where the over-the-air programming message includes programming data for use by the mobile communication device.", "The method can include providing, by the server, the encrypted over-the-air programming message to the secure device processor to enable the secure device processor to decrypt the encrypted over-the-air programming message utilizing the first keyset, where the providing of the encrypted over-the-air programming message further enables the secure device processor to provide the programming data to a secure element of the mobile communication device for provisioning of the mobile communication device, and wherein the secure device processor is separate from the secure element and in communication with the secure element.", "One embodiment of the subject disclosure is a method that includes receiving, by a secure element of a mobile communication device, a request for a first keyset, where the request is received from a secure device processor of the mobile communication device, and where the secure element is separate from the secure device processor and in communication with the secure device processor.", "The method can include providing, by the secure element, the first keyset to the secure device processor to enable the secure device processor to decrypt an over-the-air programming message to generate a decrypted over-the-air programming message, where the over-the-air programming message includes programming data for provisioning the mobile communication device.", "The method can include receiving, by the secure element from the secure device processor, the decrypted over-the-air programming message.", "The method can include performing, by the secure element, an additional decryption of the decrypted over-the-air message utilizing a second keyset, where the secure device processor does not have access to the second keyset.", "In accordance with an embodiment of the disclosure, FIG.", "1 depicts a system 100 that includes a communication device 102 connected to or otherwise in communication with a network 122 and provided with a secure services platform 110 enabling authentication of other communication devices, encrypted communication with those devices, and/or secure communications related to OTA messages.", "Device 102 can be loaded with an administrative agent function (e.g., loaded into a secure device processor 106) and/or an administrative agent key function (e.g., loaded into a secure element 108) to enable or otherwise facilitate processing of messages and responses related to OTA, including messaging with a service provisioning system via one or more OTA servers.", "It will be appreciated that the communication device 102 may be any device, including a user device, which has a secure element and a secure device processor.", "The term “user,” in this example, refers to a human user of the communication device.", "However, in other embodiments, the user can be a machine that exchanges data with the communication device 102 after being authenticated to the communication device.", "Communication device 102 can include a device processor 104, the SDP 106 and the secure element 108 (e.g., which can include a UICC).", "The secure element 108 can be various types of smart cards including a Subscriber Identification Module (SIM) card or other types of secure element.", "The secure element 108 can be a secure computing platform and can offer a high level of security for storing encryption keys, authentication credentials, and the like.", "The secure element 108 may be removable from the device.", "In other embodiments, the secure element 108 may be embedded in the device and not removable.", "In other embodiments, the secure element 108 can be placed on a memory card or an embedded chip.", "The SDP 106 can be logically and/or physically separate from the device processor 104, and can be connected to both the device processor and the secure element 108.In this embodiment, the SDP 106 can offer a higher level of security than the device processor 104, and can store and execute secure applications.", "The SDP 106 can, for example, run applications in a trusted execution environment.", "The secure element 108 and SDP 106 together can form a secure services platform 110 resident on the device 102.In this embodiment, secure element 108, SDP 106 and device processor 104 can each have a security level associated therewith, and the security level associated with the SDP 106 can be intermediate between that of the secure element 108 and that of the device processor 104.The SDP 106 and secure element 108 can use mutual authentication, as described in more detail below.", "The secure element 108 and SDP 106 can communicate with a remote management (function) server 120, located remotely from device 102.The Remote Management Server (RMS) 120 can be a platform for provisioning and/or managing applications in the secure element 108 and SDP 106.The RMS 120 can also manage data (such as keys, credentials, and so forth) that are used by the applications.", "Examples of remote management servers are described in U.S. patent application Ser.", "No.", "13/679,479 filed on Nov. 16, 2012 and U.S. patent application Ser.", "No.", "13/680,680 filed on Nov. 19, 2012, the disclosures of both of which are hereby incorporated by reference.", "In this embodiment, user device 102 can be a wireless communication device connected to a cellular network 122.Network 122 can also be other types of networks operating according to various communication protocols, such as a WiFi network.", "In other embodiments, device 102 can be connected to other devices via a wired connection through a computer.", "In still other embodiments, user devices can communicate with each other using Bluetooth, infrared communications (IRDa) and/or near field communications (NFC).", "A communication session between user devices, wherein information is transferred between the users, can be effected by a wide variety of arrangements.", "A secure application server (SAS) can be used in some embodiments to establish a secure communication session between devices.", "However, in some embodiments a secure application server may not be used where the communication session is established in a peer-to-peer manner, such as in Bluetooth, IRDa or NFC.", "System 100 enables components of the secure services platform 110 (e.g., an administrative agent function of the SDP 106) to perform operations including one or more of registering an Internet Protocol (IP) address with the OTA server 150 where the IP address is associated with the administrative agent function; receiving, from the OTA server, an OTA message that includes programming data for use by the mobile communication device where the OTA message is encrypted by the OTA server and where the OTA message utilizes a hypertext transfer protocol; decrypting the OTA message utilizing a first keyset (e.g., a transport keyset) to generate a decrypted OTA message; determining a schedule for providing messages to a secure element of the mobile communication device where the SDP is separate from the secure element and in communication with the secure element; and providing the decrypted OTA message to the secure element according to the schedule.", "System 100 enables components of the secure services platform 110 (e.g., the secure element 108) to perform operations including one or more of receiving a request for a first keyset (e.g., a transport keyset) where the request is received from an SDP of the mobile communication device and where the secure element is separate from the SDP and in communication with the SDP; providing the first keyset to the SDP to enable the SDP to decrypt an OTA message to generate a decrypted OTA message where the OTA message includes programming data for provisioning the mobile communication device; receiving the decrypted OTA message; and performing an additional decryption of the decrypted OTA message utilizing a second keyset where the SDP does not have access to the second keyset.", "In one embodiment, the secure element can receive a static key from the remote management server 120, where the remote management server provides the static key to the OTA 150 server that transmitted the OTA message to the SDP; and can generate the first keyset from the static key.", "In one embodiment, the secure element can include a UICC, wherein the OTA message utilizes HTTP, and where the receiving of the decrypted OTA message is according to a schedule generated by the SDP.", "In one embodiment, the secure element can generate a response to the OTA message; can encrypt the response utilizing the second keyset (e.g., application keyset) to generate an encrypted response; and can provide the encrypted response to the SDP for transmission to a service provisioning system 175 that originated the OTA message to enable the service provisioning system to decrypt the encrypted response utilizing the second keyset.", "In one embodiment, the OTA server 150 can receive a registration request including an internet protocol address, where the registration request is received from SDP 106 of a mobile communication device.", "The OTA server 150 can encrypt an OTA message utilizing a first keyset to generate an encrypted OTA message, where the OTA message includes programming data for use by the mobile communication device.", "The OTA server 150 can provide the encrypted OTA message to the SDP 106 to enable the SDP to decrypt the encrypted OTA message utilizing the first keyset, where the providing of the encrypted OTA message further enables the SDP to provide the programming data to a secure element (e.g., UICC 108) of the mobile communication device for provisioning of the mobile communication device, and where the SDP is separate from the secure element and in communication with the secure element.", "In one embodiment, the OTA server 150 can receive the OTA message from the service provisioning system 175, where the OTA message is encrypted by the service provisioning system 175 utilizing a second keyset (e.g., application keyset), where the second keyset is accessible to the secure element and the service provisioning system, and where the second keyset is not accessible to the server and the secure device processor.", "In one embodiment, the providing of the encrypted OTA message to the SDP utilizes HTTP.", "In one embodiment, the OTA server 150 can receive a static key from the remote management server 120, where the remote management server provides the static key to the secure element to enable the secure element to generate, or otherwise derive, a key of the first keyset from the static key and to enable the secure element to provide the first keyset to the SDP.", "In one embodiment, the OTA server can generate another key of the first keyset from the static key.", "In one embodiment, the first keyset can be provided to the OTA server 150 and to the mobile communication device by the remote management server 120.In one embodiment, the OTA server 150 can receive the OTA message from the service provisioning system 175; can receive a request from the service provisioning system to provide the OTA message to another mobile communication device; can determine that another secure device processor of the other mobile communication device is not registered with the OTA server; and can provide a notice to the service provisioning system indicating that the other secure device processor is not registered with the server.", "In one embodiment, the OTA server 150 can receive a response to the OTA message; can decrypt the response utilizing the first keyset to generate a decrypted response; and can provide the decrypted response to the service provisioning system 175 that originated the OTA message.", "In one embodiment, the OTA server 150 can store the message for transmission later.", "In another embodiment, the OTA server 150 can retransmit the message, if necessary.", "FIG.", "2 is a schematic illustration 200 showing details of a secure services platform 110, according to an embodiment of the disclosure, which can be used with the communication device 102 of FIG.", "1.The secure element 108 can contain an authentication management function 202 and a real-time encryption key generator 204.The authentication management function 202 can provide authentication services for the device.", "For example, the authentication management function 202 can support mutual authentication of devices, support a mutual authentication of the device, such as with the RMS 120 of FIG.", "1.As shown in FIG.", "2, the authentication management function 202 can include a user authentication service 212 for authenticating the user to the device and a network authentication service 214 for authenticating the device to network equipment.", "The real-time encryption key generator 204 can supply encryption keys to a real-time encryption engine 206 which is located in the SDP 106.The real-time encryption engine 206 can encrypt and decrypt user information transmitted to or from a bearer path 216 that terminates at another device (e.g., another user device), and may encrypt and decrypt information transmitted on a signaling path 218 to the network.", "In another embodiment, the encryption engine can be loaded on a second secure element, separate from the secure element 108.The RMS 120 can perform a remote provisioning and management function 210 to load applications, content and/or other information (e.g., various keysets) into the secure element 108 and/or SDP 106.In this embodiment, the RMS 120 can provision the authentication management function 202 and real-time encryption key generator 204 on the secure element 108, and can provision the real-time encryption engine 206 on the SDP 106.This can be done securely by the use of one or more remote management keysets.", "In one embodiment, before the secure services platform 110 can be used for communication, the SDP 106 can be authenticated by the secure element 108.In one embodiment, this can be done using a UICC-SDP keyset.", "The UICC-SDP keyset may be provisioned remotely by the RMS 120 or locally by an authorized user.", "In this embodiment, after the secure element 108 and SDP 106 are mutually authenticated using the UICC-SDP keyset, they can communicate via a signaling path 208 within the secure services platform 110.The UICC-SDP keyset may be used for secure communication during initial loading and provisioning.", "However, the keys being utilized may be different.", "In one embodiment, the path between the secure element 108 and the SDP 106 can go through the device processor 104 rather than directly between the secure element and the SDP.", "In this embodiment of FIG.", "2, the secure services platform 110 enables processing messages and responses related to OTA.", "These messages can be authenticated and/or encrypted utilizing various keysets that are exclusive to various devices or components so that the end points of the communication (e.g., the secure element and the service provisioning system) securely receive the programming data and/or the response related to the programming data.", "Various keysets can be distributed between pairs of devices or components, such as providing an SDP keyset to both of the administrative agent key function (of the secure element 108) and the administrative agent function (of the SDP 106), providing a transport keyset to both of the OTA server and the administrative agent function, and/or providing an application keyset to both the service provisioning system and the secure element.", "In one embodiment, the provisioning of one or more of these keysets can be performed by the remote management server, such as through use of remote management keysets.", "Referring to FIGS.", "3A-B, a system 300 is depicted which illustrates a secure process for providing messages and responses related to OTA.", "System 300 can include managing HTTP-based OTA traffic from multiple sources to the secure element (e.g., UICC).", "In one embodiment, HTTP-based OTA messages can be sent from a service provisioning system to the secure element via a network-based OTA server and a device-based administrative agent function (e.g., operating in the secure device processor).", "The OTA server can prepare the message for OTA transport and may provide additional security, such as in the form of authentication and/or encryption.", "The administrative agent function, which can be located in or otherwise operated by the SDP, can receive HTTP-based OTA messages from one or more OTA servers, and can manage the delivery of the messages to the secure element, such as the UICC.", "The administrative agent function can also support additional security measures that were performed by the OTA server.", "In one embodiment, the OTA server can perform transmitting and receiving messages to/from one or more service provisioning systems; transmitting and receiving messages to/from the UICC via the administrative agent function; and/or authenticating the administrative agent function and encrypting the OTA message.", "In one embodiment, the SDP can contain or otherwise execute the administrative agent function.", "The SDP can be a processor that is logically and/or physically separate from the device processor and/or the secure element, and can offer more hardened security than the device processor, but not as much security as the UICC.", "The administrative agent function can perform one or more of transmitting and receiving messages to/from one or more OTA servers; providing transport security between itself and an OTA server; encrypting and decrypting messages using one or more transport keys; transmitting and receiving messages to/from the secure element; and managing the communication path to the secure element such as message queuing, scheduling (e.g., scheduling packets for transmission), response correlation (e.g., tracking and correlating responses for each transmission) and/or reliable delivery via retransmission.", "The SDP can also register an IP address (e.g., the IP address associated with the administrative agent function) with the OTA server.", "In one embodiment, the secure element (e.g., the UICC) may contain or otherwise execute an administrative agent key function that can provide transport key(s), which are derived from a static key(s), to the administrative agent function.", "The secure element can perform security operations that were initiated by the service provisioning system, such as decryption based on application keysets.", "In one embodiment, multiple OTA servers can communicate with a single administrative agent function.", "In one embodiment, the transport key can be preloaded into the UICC (and/or the OTA server) or the transport key can be generated, or otherwise derived, from a static key (which in some embodiments can be derived from a master key).", "In one embodiment, the remote management server can manage the applications on both the secure element and the SDP.", "For example, the remote management server can manage the download of static keys (for deriving the transport keys) and/or transport keys, as well as the status of existing transport keys.", "These transport keys may exist in either or both of the administrative agent key function and the administrative agent function.", "The remote management server can also provide a static key (for generating a transport key) and/or transport keys to other devices, such as the OTA server.", "These operations can be done securely by the use of one or more remote management keysets.", "These keysets can be used to mutually authenticate the secure element and SDP with the remote management server and/or to enable encryption between them.", "In one embodiment, the remote management server may use existing Short Message Service (SMS)-based OTA messaging to manage the secure element, including the administrative agent key function.", "In one embodiment, the remote management server can be the source of the static key and/or may store the static key.", "In one embodiment, the remote management server can provide the static key to the secure element and to the OTA server.", "In one embodiment, the secure element and the OTA server can use the static key to generate or otherwise derive the transport key.", "In another embodiment, the remote management server can provide a static keyset to the secure element and the OTA server.", "In one embodiment, the static keyset can be a master key or can be a static key that is derived from the master key.", "In one example, both the secure element and the OTA server can use the static key to derive the transport keys of the transport keyset.", "In one embodiment, the remote management server may store the static keyset.", "In another embodiment, a static key (e.g., derived from a master key by the remote management server) may be sent to the UICC and the OTA server, such as by the remote management server.", "The static key can be used to derive dynamic transport keys.", "In one embodiment, the UICC and the OTA server can be provided with the first keyset (e.g., transport keys), such as by the remote management server.", "Referring to FIGS.", "4A-B, system 400 is depicted which illustrates loading or otherwise provisioning the end user device(s) with the applications that are utilized by the secure services platform for performing the secure OTA messaging process.", "In one embodiment, there can be a plurality of applications to be loaded or otherwise provisioned, such as the administrative agent function and the administrative agent key function.", "For example, if the applications have not been loaded at the factory, then at 1a the remote management server can download the administrative agent function to the SDP and the administrative agent key function to the secure element.", "In one embodiment, remote management keysets can be used to securely transmit information from the remote management server to the UE(s).", "This process can utilize mutual authentication and/or encryption.", "In one embodiment, the remote management server may use SMS-based OTA to manage the secure element, including the download of the administrative agent key function.", "At 1b, the administrative agent function and the administrative agent key function can mutually authenticate with each other, such as through utilizing an SDP keyset.", "The administrative agent function can verify that it is able to communicate with the administrative agent key function.", "At 1c, the remote management server can download one or more transport keys to the administrative agent key function and/or directly to the administrative agent function.", "This can be performed using a remote management keyset.", "As described above, the remote management server may use SMS-based OTA to manage the secure element, which may include the loading of the transport keys.", "In one embodiment, the remote management server may download the static key (which can be a master key or can be derived from a master key), or one or more transport keys to the administrative agent key function and/or directly to the administrative agent function.", "The static key can be used for deriving, by the remote management server, a key of the transport keys.", "At 1d, the remote management server can provide the transport key to one or more OTA servers.", "In one embodiment, the remote management server may download a static key (which can be a master key), or one or more transport keys to the OTA server.", "The static key can be used for deriving, by the OTA server, a key of the transport keys.", "At 1e, the administrative agent function can register its IP address with one or more OTA servers.", "This process can include mutual authentication and/or encryption using the transport keys.", "Referring to FIGS.", "5A-B, system 500 is depicted which illustrates a process for securely communicating messages and responses related to OTA.", "The process is based on the OTA server forwarding an OTA message from a service provisioning system to the administrative agent function for transmission to the secure element.", "At 2a, a service provisioning system can prepare a message to be sent to the secure element.", "This message can be HTTP-based and may be encrypted using an application keyset.", "At 2b, the OTA server can receive the OTA message and can prepare to transmit the OTA message to the administrative agent function via HTTP.", "The OTA server may use a suitable transport key to authenticate the administrative agent function and encrypt the message.", "In one embodiment, if the administrative agent function has not registered with the OTA server, the OTA server can provide a suitable response back to the service provisioning system.", "In one embodiment, if the administrative agent function is not registered with the OTA server then the OTA server can store the OTA message for transmission at a later time, such as when the administrative agent function becomes registered.", "In one embodiment, periodic monitoring for registration can be performed.", "At 2c, the administrative agent function can receive the message and can check to see if it is encrypted and authenticated with a transport key.", "If not, the administrative agent function can act upon the message as described in Step 2f.", "If so, the administrative agent function can determine whether or not it has the proper key to decrypt the message and can authenticate the OTA server.", "If it does then it can decrypt the message using its own transport key, can authenticate the OTA server, and can act upon the message as described in Step 2f.", "At 2d, if the message is encrypted with a transport key and the administrative agent function does not have a corresponding transport key to decrypt it, the administrative agent function can ask the administrative agent key function to provide one.", "To do this, the administrative agent function can generate a request and can transmit the request to the administrative agent key function which can respond with a suitable transport key.", "In one embodiment, the key provided by the administrative agent key function can be derived from a static key stored by or otherwise accessible to the administrative agent key function.", "At 2e, the administrative agent function can decrypt the message using either its own transport key or one provided by the administrative agent key function.", "The administrative agent function can then authenticate the OTA server.", "At 2f, the administrative agent function can schedule the message for transmission to a UICC terminating entity (such as through generating a messaging schedule).", "Once the message is ready for transmission, the administrative agent function can schedule it for transmission, can transmit it at the scheduled time, can track the response from the secure element, and can retransmit if necessary.", "At 2g, the UICC terminating entity can receive the message and can perform actions based on the content of the message, such as software update configuration setting adjustments, and so forth.", "If the message is encrypted with an application key, the UICC terminating entity can decrypt the message using its own application key.", "The UICC terminating entity may also respond to the message.", "At 2i, if a response is provided, then the response will travel back to the administrative agent function.", "The administrative agent function can correlate or otherwise map the response to the initial OTA message, encrypt the response with a transport key if desired, and transmit the response to the OTA server.", "At 2j, the OTA server can receive the response to the initial OTA message.", "In one embodiment, the OTA server can perform decryption utilizing the first keyset (e.g., a transport key).", "At 2k, the OTA server can transmit the response back to the service provisioning system.", "In one embodiment, the service provisioning system can perform decryption utilizing another keyset (e.g., an application key).", "FIG.", "6 depicts an illustrative embodiment of a method for providing secure over-the-air programming of a communication device.", "All or a portion of the steps of method 600 can be performed by various devices, including end user devices such as device 102 including secure services platform 110.More or less than the steps described in method 600 can be performed in one or more exemplary embodiments, and the order of steps can be rearranged.", "Method 600 can begin at 602 where a registration between a secure device processor (e.g., an administrative agent function) of a mobile communication device and an OTA server occurs.", "The registration can include the administrative agent function providing an internet protocol address to the OTA server, wherein the internet protocol address is associated with the administrative agent function.", "At 604, the administrative agent function can receive, from the OTA server, an OTA message.", "The OTA message can include programming data for use by the mobile communication device (e.g., usable by the secure element).", "In one embodiment, the OTA message can be encrypted by the OTA server.", "In another embodiment, the OTA message can utilize HTTP, although other transport protocols can also be used, such as SMS-based messaging.", "The programming data of the OTA message can be of various types including software updates, configuration settings, and/or other information that is utilized by the mobile communication device.", "The programming data can be over-the-air service provisioning (OTASP), over-the-air provisioning (OTAP) and/or over-the-air parameter administration (OTAPA).", "At 606, the administrative agent function can detect an encryption of the OTA message and can decrypt it utilizing a first keyset (e.g., a transport keyset) to generate a decrypted OTA message.", "In one embodiment at 608, the administrative agent function can determine whether it has possession of the first keyset (e.g., stored in a memory of the secure device processor) and, if not, the administrative agent function can provide a keyset request to the secure element.", "In response to the request, the secure element (e.g., an administrative agent key function operating in a UICC) can provide the requested keyset (e.g., the transport keyset) to the administrative agent function.", "In one embodiment, the communication between the administrative agent function of the secure device processor and the administrative agent key function of the secure element can be based on a mutual authentication that utilizes SDP keyset provided to both the secure element and the secure device processor by the remote management server utilizing remote management keyset.", "At 610, the administrative agent function can determine or otherwise generate a schedule for providing messages to the secure element of the mobile communication device.", "In this embodiment, the secure device processor is separate from the secure element and in communication with the secure element, as described in FIGS.", "1 and 2.At 612, the administrative agent function can provide the decrypted OTA message to the secure element according to the schedule to enable the secure element (e.g., a UICC terminating entity operating in the secure element) to utilize the programming data of the OTA message, such as for provisioning of the mobile communication device (e.g., software updates, configuration setting adjustments, and so forth).", "In one embodiment, the secure element can comprise a UICC.", "In one embodiment, the method 600 can further include one or more of monitoring, by the administrative agent function, for a response provided by the secure element; determining, by the administrative agent function, that the response is associated with the OTA message; encrypting, by the administrative agent function, the response utilizing the first keyset to generate an encrypted response; and providing, by the administrative agent function, the encrypted response to the OTA server to enable the OTA server to decrypt the encrypted response for transmission, such as to a service provisioning system that originated or is otherwise associated with the OTA message.", "In one embodiment, the providing of the decrypted OTA message to the secure element enables the secure element to further decrypt the decrypted OTA message utilizing a second keyset (e.g., an application keyset).", "In one embodiment, the application keyset can be stored by or otherwise accessible to the secure element and the service provisioning system.", "In another embodiment, the application keyset may not be accessible to the secure device processor.", "In another embodiment, the application keyset may not be accessible to the OTA server.", "In one embodiment, method 600 can include authenticating, by the administrative agent function, with the secure element utilizing a third keyset (e.g., an SDP keyset).", "In one embodiment, the first keyset can be generated or otherwise derived by the secure element (e.g., the administrative agent key function) from a static key that is provided by a remote management server to the secure element and to the OTA server.", "In another embodiment, the providing of the static key to the secure element by the remote management server can be based on another OTA message that utilizes SMS transport protocol (e.g., SMPP).", "In one embodiment the static key can be a master key or can be derived from a master key.", "In one embodiment, method 600 can include receiving, by the administrative agent function, the first keyset (e.g., transport keyset) from a remote management server, where the remote management server provides the first keyset to the OTA server, and where the receiving of the first keyset by the administrative agent function is performed utilizing a remote management keyset.", "In one embodiment, the administrative agent function can be downloaded to the secure device processor utilizing the remote management keyset.", "In one embodiment, the administrative agent key function can be downloaded to the secure element utilizing the remote management keyset.", "In one embodiment, the OTA message can originate from a service provisioning system, where the providing of the decrypted OTA message to the secure element enables the secure element to further decrypt the decrypted OTA message utilizing a second keyset (e.g., application keyset), where the administrative agent function and the OTA server do not have access to the second keyset, and wherein the service provisioning system has access to the second keyset.", "In one embodiment, the method 600 can include one or more of determining, by the administrative agent function, that a response has been generated by the secure element and is associated with the OTA message; and providing, by the administrative agent function, the response to the OTA server for transmission to the service provisioning system.", "In one embodiment, the response can be encrypted by the secure element utilizing the second keyset (e.g., application keyset), where the response is configured for decryption by the service provisioning system utilizing the second keyset.", "In one embodiment, method 600 can include providing, by the administrative agent function, a request to the secure element for the first keyset responsive to a determination that the OTA message has been encrypted; and receiving, by the administrative agent function, the first keyset from the secure element.", "In another embodiment, the static key can be provided to the secure element (e.g., the administrative agent key function) and the OTA server for deriving of the transport keys, respectively, of the transport keyset.", "In one embodiment, method 600 can include retransmitting, by the administrative agent function, the decrypted OTA message to the secure element.", "FIG.", "7 depicts an illustrative embodiment of a communication system 700 for delivering media content.", "The communication system 700 can represent an Internet Protocol Television (IPTV) media system.", "Communication system 700 can be overlaid or operably coupled with systems 100, 200 of FIGS.", "1 and 2 as another representative embodiment of communication system 700.In one or more embodiments, system 700 enables utilizing both the secure element and SDP together to provide a secure platform for delivering messages and responses related to OTA.", "System 700 can enable registering an IP address with an OTA server; receiving, from the OTA server, an OTA message that includes programming data for use by the mobile communication device, where the OTA message is encrypted by the OTA server and utilizes HTTP; decrypting the OTA message utilizing a first keyset to generate a decrypted OTA message; determining a schedule for providing messages to a secure element of the mobile communication device; and providing the decrypted OTA message to the secure element according to the schedule.", "In one or more embodiments, system 700 enables authentication and/or encryption to be performed between various devices (or components of a single device) based on keysets distributed between pairs of devices or components, such as providing an SDP keyset to both of the secure element and the SDP, providing a transport keyset to both of the SDP and the OTA server, and/or providing an application keyset to both the secure element and the service provisioning system.", "The distribution of these keysets can be exclusive between the pairs of devices or components or can be non-exclusive.", "The IPTV media system can include a super head-end office (SHO) 710 with at least one super headend office server (SHS) 711 which receives media content from satellite and/or terrestrial communication systems.", "In the present context, media content can represent, for example, audio content, moving image content such as 2D or 3D videos, video games, virtual reality content, still image content, and combinations thereof.", "The SHS server 711 can forward packets associated with the media content to one or more video head-end servers (VHS) 714 via a network of video head-end offices (VHO) 712 according to a multicast communication protocol.", "The VHS 714 can distribute multimedia broadcast content via an access network 718 to commercial and/or residential buildings 702 housing a gateway 704 (such as a residential or commercial gateway).", "The access network 718 can represent a group of digital subscriber line access multiplexers (DSLAMs) located in a central office or a service area interface that provide broadband services over fiber optical links or copper twisted pairs 719 to buildings 702.The gateway 704 can use communication technology to distribute broadcast signals to media processors 706 such as Set-Top Boxes (STBs) which in turn present broadcast channels to media devices 708 such as computers or television sets managed in some instances by a media controller 707 (such as an infrared or RF remote controller).", "The gateway 704, the media processors 706, and media devices 708 can utilize tethered communication technologies (such as coaxial, powerline or phone line wiring) or can operate over a wireless access protocol such as Wireless Fidelity (WiFi), Bluetooth, Zigbee, or other present or next generation local or personal area wireless network technologies.", "By way of these interfaces, unicast communications can also be invoked between the media processors 706 and subsystems of the IPTV media system for services such as video-on-demand (VoD), browsing an electronic programming guide (EPG), or other infrastructure services.", "A satellite broadcast television system 729 can be used in the media system of FIG.", "7.The satellite broadcast television system can be overlaid, operably coupled with, or replace the IPTV system as another representative embodiment of communication system 700.In this embodiment, signals transmitted by a satellite 715 that include media content can be received by a satellite dish receiver 731 coupled to the building 702.Modulated signals received by the satellite dish receiver 731 can be transferred to the media processors 706 for demodulating, decoding, encoding, and/or distributing broadcast channels to the media devices 708.The media processors 706 can be equipped with a broadband port to an Internet Service Provider (ISP) network 732 to enable interactive services such as VoD and EPG as described above.", "In yet another embodiment, an analog or digital cable broadcast distribution system such as cable TV system 733 can be overlaid, operably coupled with, or replace the IPTV system and/or the satellite TV system as another representative embodiment of communication system 700.In this embodiment, the cable TV system 733 can also provide Internet, telephony, and interactive media services.", "The subject disclosure can apply to other present or next generation over-the-air and/or landline media content services system.", "Some of the network elements of the IPTV media system can be coupled to one or more computing devices 730, a portion of which can operate as a web server for providing web portal services over the ISP network 732 to wireline media devices 708 or wireless communication devices 716.Communication system 700 can also provide for computing devices 730 to function as a remote management server, an OTA server and/or a service provisioning system (herein referred to as server 730).", "The server 730 can use computing and communication technology to perform function 762, which can include among other things, provisioning various devices or components, such as through use of remote management keysets.", "The provisioning can be of applications, such as the administrative agent function and/or the administrative agent key function, and/or can be of keysets, such as transport keysets.", "Function 762 can include one or more of receiving a registration request including an IP address, where the registration request is received from a secure device processor of a mobile communication device; encrypting an OTA message utilizing a first keyset to generate an encrypted OTA message, where the OTA message includes programming data for use by the mobile communication device; and providing the encrypted OTA message to the secure device processor to enable the secure device processor to decrypt the encrypted OTA message utilizing the first keyset.", "In one embodiment, the providing of the encrypted OTA message can further enable the secure device processor to provide the programming data to a secure element of the mobile communication device for provisioning of the mobile communication device.", "In another embodiment, the secure device processor can be separate from the secure element and in communication with the secure element.", "Function 766 can include functions being performed at the secure element 108 including one or more of receiving a request for a first keyset, where the request is received from a secure device processor of the mobile communication device, and where the secure element is separate from the secure device processor and in communication with the secure device processor; providing the first keyset to the secure device processor to enable the secure device processor to decrypt an OTA message to generate a decrypted OTA message where the OTA message includes programming data for provisioning the mobile communication device; receiving, from the secure device processor, the decrypted OTA message; and performing an additional decryption of the decrypted OTA message utilizing a second keyset.", "In one embodiment, the secure device processor does not have access to the second keyset.", "Function 766 can also include functions being performed at the SDP 106 such as one or more of registering an IP address with an OTA server, where the IP address is associated with the administrative agent function; receiving, from the OTA server, an OTA message that includes programming data for use by the mobile communication device, where the OTA message is encrypted by the OTA server, where the OTA message utilizes HTTP; decrypting the OTA message utilizing a first keyset (e.g., transport keyset) to generate a decrypted OTA message; determining a schedule for providing messages to a secure element of the mobile communication device where the secure device processor is separate from the secure element and in communication with the secure element; and providing the decrypted OTA message to the secure element according to the schedule.", "Multiple forms of media services can be offered to media devices over landline technologies such as those described above.", "Additionally, media services can be offered to media devices by way of a wireless access base station 717 operating according to common wireless access protocols such as Global System for Mobile or GSM, Code Division Multiple Access or CDMA, Time Division Multiple Access or TDMA, Universal Mobile Telecommunications or UMTS, World interoperability for Microwave or WiMAX, Software Defined Radio or SDR, Long Term Evolution or LTE, and so on.", "Other present and next generation wide area wireless access network technologies can be used in one or more embodiments of the subject disclosure.", "FIG.", "8 depicts an illustrative embodiment of a communication device 800.Communication device 800 can serve in whole or in part as an illustrative embodiment of the devices depicted in FIGS.", "1-5 and 7.For instance, device 800 can include a secure element (e.g., executing an administrative agent key function) and a secure device processor (executing an administrative agent function) in the secure services platform 110 which perform the functions described in the exemplary embodiments herein.", "In one or more embodiments, the secure element of device 800 can perform operations including generating transport keys from a static key and providing the transport key to the SDP so that the SDP can authenticate, encrypt and/or decrypt in conjunction to messages/responses of the OTA server.", "The secure element can also decrypt OTA messages originated from the service provisioning system; generate and encrypt responses to the OTA message that are to be transmitted (by the SDP) to the service provisioning system; and/or utilize programming data included in the OTA message (e.g., updating software, adjusting device settings, and so forth).", "In other embodiments, static keys can be selectively distributed to enable deriving the transport keyset.", "In one or more embodiments, the SDP (e.g., the administrative agent function) of device 800 can perform operations including authenticate, encrypt and/or decrypt in conjunction to messages/responses of the OTA server; request transport keys from the secure element; schedule transmissions of OTA messages to the secure element; and/or retransmit OTA messages to the secure element.", "To enable these features, communication device 800 can comprise a wireline and/or wireless transceiver 802 (herein transceiver 802), a user interface (UI) 804, a power supply 814, a location receiver 816, a motion sensor 818, an orientation sensor 820, and a controller 806 for managing operations thereof.", "The transceiver 802 can support short-range or long-range wireless access technologies such as Bluetooth, ZigBee, WiFi, DECT, or cellular communication technologies, just to mention a few.", "Cellular technologies can include, for example, CDMA-1X, UMTS/HSDPA, GSM/GPRS, TDMA/EDGE, EV/DO, WiMAX, SDR, LTE, NFC, as well as other next generation wireless communication technologies as they arise.", "The transceiver 802 can also be adapted to support circuit-switched wireline access technologies (such as PSTN), packet-switched wireline access technologies (such as TCP/IP, VoIP, etc.", "), and combinations thereof.", "The UI 804 can include a depressible or touch-sensitive keypad 808 with a navigation mechanism such as a roller ball, a joystick, a mouse, or a navigation disk for manipulating operations of the communication device 800.The keypad 808 can be an integral part of a housing assembly of the communication device 800 or an independent device operably coupled thereto by a tethered wireline interface (such as a USB cable) or a wireless interface supporting for example Bluetooth.", "The keypad 808 can represent a numeric keypad commonly used by phones, and/or a QWERTY keypad with alphanumeric keys.", "The UI 804 can further include a display 810 such as monochrome or color LCD (Liquid Crystal Display), OLED (Organic Light Emitting Diode) or other suitable display technology for conveying images to an end user of the communication device 800.In an embodiment where the display 810 is touch-sensitive, a portion or all of the keypad 808 can be presented by way of the display 810 with navigation features.", "The display 810 can use touch screen technology to also serve as a user interface for detecting user input.", "As a touch screen display, the communication device 800 can be adapted to present a user interface with graphical user interface (GUI) elements that can be selected by a user with a touch of a finger.", "The touch screen display 810 can be equipped with capacitive, resistive or other forms of sensing technology to detect how much surface area of a user's finger has been placed on a portion of the touch screen display.", "This sensing information can be used to control the manipulation of the GUI elements or other functions of the user interface.", "The display 810 can be an integral part of the housing assembly of the communication device 800 or an independent device communicatively coupled thereto by a tethered wireline interface (such as a cable) or a wireless interface.", "The UI 804 can also include an audio system 812 that utilizes audio technology for conveying low volume audio (such as audio heard in proximity of a human ear) and high volume audio (such as speakerphone for hands free operation).", "The audio system 812 can further include a microphone for receiving audible signals of an end user.", "The audio system 812 can also be used for voice recognition applications.", "The UI 804 can further include an image sensor 813 such as a charged coupled device (CCD) camera for capturing still or moving images.", "The power supply 814 can utilize common power management technologies such as replaceable and rechargeable batteries, supply regulation technologies, and/or charging system technologies for supplying energy to the components of the communication device 800 to facilitate long-range or short-range portable applications.", "Alternatively, or in combination, the charging system can utilize external power sources such as DC power supplied over a physical interface such as a USB port or other suitable tethering technologies.", "The location receiver 816 can utilize location technology such as a global positioning system (GPS) receiver capable of assisted GPS for identifying a location of the communication device 800 based on signals generated by a constellation of GPS satellites, which can be used for facilitating location services such as navigation.", "The motion sensor 818 can utilize motion sensing technology such as an accelerometer, a gyroscope, or other suitable motion sensing technology to detect motion of the communication device 800 in three-dimensional space.", "The orientation sensor 820 can utilize orientation sensing technology such as a magnetometer to detect the orientation of the communication device 800 (north, south, west, and east, as well as combined orientations in degrees, minutes, or other suitable orientation metrics).", "The communication device 800 can use the transceiver 802 to also determine a proximity to a cellular, WiFi, Bluetooth, or other wireless access points by sensing techniques such as utilizing a received signal strength indicator (RSSI) and/or signal time of arrival (TOA) or time of flight (TOF) measurements.", "The controller 806 can utilize computing technologies such as a microprocessor, a digital signal processor (DSP), programmable gate arrays, application specific integrated circuits, and/or a video processor with associated storage memory such as Flash, ROM, RAM, SRAM, DRAM or other storage technologies for executing computer instructions, controlling, and processing data supplied by the aforementioned components of the communication device 800.Other components not shown in FIG.", "8 can be used in one or more embodiments of the subject disclosure.", "For instance, the communication device 800 can include a reset button (not shown).", "The reset button can be used to reset the controller 806 of the communication device 800.In yet another embodiment, the communication device 800 can also include a factory default setting button positioned, for example, below a small hole in a housing assembly of the communication device 800 to force the communication device 800 to re-establish factory settings.", "In this embodiment, a user can use a protruding object such as a pen or paper clip tip to reach into the hole and depress the default setting button.", "In one embodiment, the communication device 800 can also include a slot for adding or removing the UICC.", "The communication device 800 as described herein can operate with more or less of the circuit components shown in FIG.", "8.These variant embodiments can be used in one or more embodiments of the subject disclosure.", "The communication device 800 can be adapted to perform the functions of the media processor 706, the media devices 708, the portable communication devices 716 and/or the server 730 of FIG.", "7.It will be appreciated that the communication device 800 can also represent other devices that can operate in communication system 700 of FIG.", "7, such as a gaming console and a media player.", "The communication device 800 shown in FIG.", "8 or portions thereof can serve as a representation of one or more of the devices of FIGS.", "1-5 and 7 including end user devices, customer premises equipment, remote management servers, OTA servers and/or service provisioning system.", "In one or more embodiments, the OTA server 150 and/or the service provisioning system can be operated by, or otherwise affiliated with, a third party entity that is different from and/or independent of the service provider operating the RMS 120.In addition, the controller 806 can perform the functions 762 and/or 766.Upon reviewing the aforementioned embodiments, it would be evident to an artisan with ordinary skill in the art that said embodiments can be modified, reduced, or enhanced without departing from the scope of the claims described below.", "For example, in the event that a secure element and/or SDP is determined to be inaccessible (such as via an HTTP message) from the OTA server, an alert can be generated to implement techniques for delivering of the OTA message as described in the U.S. Patent Application entitled “Apparatus and Method for Secure Over The Air Programming of a Communication Device” with Docket No.", "2013-1003_7785-1043, Application Ser.", "No., 14/069,908, issued as U.S. Pat.", "No.", "9,240,989, the disclosure of which is hereby incorporated by reference.", "For instance, the alert can be transmitted to the mobile device to indicate that OTA programming data is available.", "In another embodiment, the alert can cause a network interworking function or another network element to determine if there are other alternate delivery techniques available for the secure element.", "In one embodiment, encryption can be applied by the service provisioning system to the OTA message or by the secure element to the response based on various encryption techniques including elliptical curve cryptography, Advance Encryption Standard (AES), and so forth.", "Other encryption techniques can be utilized, including symmetrical and/or asymmetrical cryptographic methods.", "In another embodiment, the mobile communication device can communicate with the service provisioning system (or another device) via the administrative agent function to transfer various information (e.g., in a secure message), which may or may not be related to the OTA message.", "This information can be provided with the various security procedures described above with respect to one or more of the exemplary embodiments, including encrypting with application keyset (e.g., done at the secure element), encrypting with transport keyset (e.g., done at an application agent function of the mobile communication device), and/or authentication between various devices and/or components (e.g., authentication between the secure element and the administrative agent function, authentication between the OTA server and the administrative agent function, and so forth).", "As an example, the secure element can generate a secure message for transmission; encrypt the secure message utilizing the second keyset (e.g., application keyset) to generate an encrypted secure message; and provide the encrypted secure message to the secure device processor for transmission to a destination device via an intermediate server (e.g., OTA server) to enable the destination device to decrypt the encrypted secure message utilizing the second keyset, where the encrypted secure message is further encrypted by the secure device processor utilizing the first keyset (e.g., transport keyset), and where the encrypted secure message is further decrypted by the intermediate server utilizing the first keyset prior to delivery to the intermediate server.", "In one embodiment, the OTA server can re-encrypt a message that the OTA server received from a device before transmitting to another device.", "In one embodiment, the OTA server can be an OTA server function, the remote management server can be a remote management server function, and both the OTA server function and the remote management server function can operate from a single device or from a group of devices (where each device of the group executes both functions).", "In another embodiment, the OTA server and the remote management server are separate devices.", "In one embodiment, each transport key of the transport keyset can be static or dynamic Other embodiments can be used in the subject disclosure.", "It should be understood that devices described in the exemplary embodiments can be in communication with each other via various wireless and/or wired methodologies.", "The methodologies can be links that are described as coupled, connected and so forth, which can include unidirectional and/or bidirectional communication over wireless paths and/or wired paths that utilize one or more of various protocols or methodologies, where the coupling and/or connection can be direct (e.g., no intervening processing device) and/or indirect (e.g., an intermediary processing device such as a router).", "FIG.", "9 depicts an exemplary diagrammatic representation of a machine in the form of a computer system 900 within which a set of instructions, when executed, may cause the machine to perform any one or more of the methods described above.", "One or more instances of the machine can operate, for example, as the remote management server, the service provisioning system, the OTA server, the secure services platform (e.g., the secure element and/or the administrative agent function of the SDP), the device processor, and so forth.", "In some embodiments, the machine may be connected (e.g., using a network 926) to other machines.", "In a networked deployment, the machine may operate in the capacity of a server or a client user machine in server-client user network environment, or as a peer machine in a peer-to-peer (or distributed) network environment.", "The machine may comprise a server computer, a client user computer, a personal computer (PC), a tablet PC, a smart phone, a laptop computer, a desktop computer, a control system, a network router, switch or bridge, or any machine capable of executing a set of instructions (sequential or otherwise) that specify actions to be taken by that machine.", "It will be understood that a communication device of the subject disclosure includes broadly any electronic device that provides voice, video or data communication.", "Further, while a single machine is illustrated, the term “machine” shall also be taken to include any collection of machines that individually or jointly execute a set (or multiple sets) of instructions to perform any one or more of the methods discussed herein.", "The computer system 900 may include a processor (or controller) 902 (e.g., a central processing unit (CPU)), a graphics processing unit (GPU, or both), a main memory 904 and a static memory 906, which communicate with each other via a bus 908.The computer system 900 may further include a display unit 910 (e.g., a liquid crystal display (LCD), a flat panel, or a solid state display).", "The computer system 900 may include an input device 912 (e.g., a keyboard), a cursor control device 914 (e.g., a mouse), a disk drive unit 916, a signal generation device 918 (e.g., a speaker or remote control) and a network interface device 920.In distributed environments, the embodiments described in the subject disclosure can be adapted to utilize multiple display units 910 controlled by two or more computer systems 900.In this configuration, presentations described by the subject disclosure may in part be shown in a first of the display units 910, while the remaining portion is presented in a second of the display units 910.The disk drive unit 916 may include a tangible computer-readable storage medium 922 on which is stored one or more sets of instructions (e.g., software 924) embodying any one or more of the methods or functions described herein, including those methods illustrated above.", "The instructions 924 may also reside, completely or at least partially, within the main memory 904, the static memory 906, and/or within the processor 902 during execution thereof by the computer system 900.The main memory 904 and the processor 902 also may constitute tangible computer-readable storage media.", "Dedicated hardware implementations including, but not limited to, application specific integrated circuits, programmable logic arrays and other hardware devices that can likewise be constructed to implement the methods described herein.", "Application specific integrated circuits and programmable logic array can use downloadable instructions for executing state machines and/or circuit configurations to implement embodiments of the subject disclosure.", "Applications that may include the apparatus and systems of various embodiments broadly include a variety of electronic and computer systems.", "Some embodiments implement functions in two or more specific interconnected hardware modules or devices with related control and data signals communicated between and through the modules, or as portions of an application-specific integrated circuit.", "Thus, the example system is applicable to software, firmware, and hardware implementations.", "In accordance with various embodiments of the subject disclosure, the operations or methods described herein are intended for operation as software programs or instructions running on or executed by a computer processor or other computing device, and which may include other forms of instructions manifested as a state machine implemented with logic components in an application specific integrated circuit or field programmable gate array.", "Furthermore, software implementations (e.g., software programs, instructions, etc.)", "including, but not limited to, distributed processing or component/object distributed processing, parallel processing, or virtual machine processing can also be constructed to implement the methods described herein.", "It is further noted that a computing device such as a processor, a controller, a state machine or other suitable device for executing instructions to perform operations or methods may perform such operations directly or indirectly by way of one or more intermediate devices directed by the computing device.", "While the tangible computer-readable storage medium 922 is shown in an example embodiment to be a single medium, the term “tangible computer-readable storage medium” should be taken to include a single medium or multiple media (e.g., a centralized or distributed database, and/or associated caches and servers) that store the one or more sets of instructions.", "The term “tangible computer-readable storage medium” shall also be taken to include any non-transitory medium that is capable of storing or encoding a set of instructions for execution by the machine and that cause the machine to perform any one or more of the methods of the subject disclosure.", "The term “non-transitory” as in a non-transitory computer-readable storage includes without limitation memories, drives, devices and anything tangible but not a signal per se.", "The term “separate” can include a component or device that is logically and/or physically separate from another component or device, which can include components/devices that operate independently of each other while being in communication with each other.", "In one or more embodiments, devices can be separate in that they do not share any common component (although such separate devices can be in communication with each other such as via an electrode coupling.", "In one or more embodiments, devices can be separate in that they each have one or more components that are not shared between each other but have one or more components that may be shared with each other.", "The term “tangible computer-readable storage medium” shall accordingly be taken to include, but not be limited to: solid-state memories such as a memory card or other package that houses one or more read-only (non-volatile) memories, random access memories, or other re-writable (volatile) memories, a magneto-optical or optical medium such as a disk or tape, or other tangible media which can be used to store information.", "Accordingly, the disclosure is considered to include any one or more of a tangible computer-readable storage medium, as listed herein and including art-recognized equivalents and successor media, in which the software implementations herein are stored.", "Although the present specification describes components and functions implemented in the embodiments with reference to particular standards and protocols, the disclosure is not limited to such standards and protocols.", "Each of the standards for Internet and other packet switched network transmission (e.g., TCP/IP, UDP/IP, HTML, HTTP, NFC) represent examples of the state of the art.", "Such standards are from time-to-time superseded by faster or more efficient equivalents having essentially the same functions.", "Wireless standards for device detection (e.g., RFID), short-range communications (e.g., Bluetooth, WiFi, Zigbee, NFC), and long-range communications (e.g., WiMAX, GSM, CDMA, LTE) can be used by computer system 900.The illustrations of embodiments described herein are intended to provide a general understanding of the structure of various embodiments, and they are not intended to serve as a complete description of all the elements and features of apparatus and systems that might make use of the structures described herein.", "Many other embodiments will be apparent to those of skill in the art upon reviewing the above description.", "The exemplary embodiments can include combinations of features and/or steps from multiple embodiments.", "Other embodiments may be utilized and derived therefrom, such that structural and logical substitutions and changes may be made without departing from the scope of this disclosure.", "Figures are also merely representational and may not be drawn to scale.", "Certain proportions thereof may be exaggerated, while others may be minimized Accordingly, the specification and drawings are to be regarded in an illustrative rather than a restrictive sense.", "Although specific embodiments have been illustrated and described herein, it should be appreciated that any arrangement calculated to achieve the same purpose may be substituted for the specific embodiments shown.", "This disclosure is intended to cover any and all adaptations or variations of various embodiments.", "Combinations of the above embodiments, and other embodiments not specifically described herein, can be used in the subject disclosure.", "In one or more embodiments, features that are positively recited can also be excluded from the embodiment with or without replacement by another component or step.", "The steps or functions described with respect to the exemplary processes or methods can be performed in any order.", "The steps or functions described with respect to the exemplary processes or methods can be performed alone or in combination with other steps or functions (from other embodiments or from other steps that have not been described).", "Less than all of the steps or functions described with respect to the exemplary processes or methods can also be performed in one or more of the exemplary embodiments.", "Further, the use of numerical terms to describe a device, component, step or function, such as first, second, third, and so forth, is not intended to describe an order or function unless expressly stated so.", "The use of the terms first, second, third and so forth, is generally to distinguish between devices, components, steps or functions unless expressly stated otherwise.", "Additionally, one or more devices or components described with respect to the exemplary embodiments can facilitate one or more functions, where the facilitating (e.g., facilitating access or facilitating establishing a connection) can include less than every step needed to perform the function or can include all of the steps needed to perform the function.", "The Abstract of the Disclosure is provided with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.", "In addition, in the foregoing Detailed Description, it can be seen that various features are grouped together in a single embodiment for the purpose of streamlining the disclosure.", "This method of disclosure is not to be interpreted as reflecting an intention that the claimed embodiments require more features than are expressly recited in each claim.", "Rather, as the following claims reflect, inventive subject matter lies in less than all features of a single disclosed embodiment.", "Thus the following claims are hereby incorporated into the Detailed Description, with each claim standing on its own as a separately claimed subject matter." ] ]
Patent_15872622
[ [ "RADIO FREQUENCY LEAKAGE DETECTION IN A CABLE PLANT", "Embodiments provided describe detections of RF leakage test signal emanating from cable plant.", "In one embodiment a single mobile receive antenna, connected to a complex demodulator mobile receiver, receives a stabilized test signal radiating from the cable plant.", "The test signal may be a known continuous wave (CW) carrier or other deterministic signal.", "The received test signal varies in phase as a function of a position of the mobile receive antenna relative to the location of a leakage antenna.", "The phase variance forms a Doppler shift as the test antenna moves relative to the leakage antenna.", "The receiver generates multiple in-phase (I) and quadrature (Q) test signal samples over a SPA (synthetic phased array) distance as the test antenna's travels, and the samples are inserted into a Fourier transform.", "The result of the transform is instantaneous Doppler frequency shift, from which a bearing angle can be computed." ], [ "1.A system for locating one or more leakage antennas radiating a leakage signal from a cable plant, comprising: a first mobile test antenna connected to a mobile receiver producing I and Q samples as the mobile test antenna moves a synthetic phased array (SPA) distance; a Fourier transformer module for converting a first set of I and Q samples into a first set of Doppler frequency components associated with a first test antenna location and a second set of I and Q samples into a second set of Doppler frequency components associated with a second antenna; a conversion module configured to convert the first set of Doppler frequency components into first bearing angle associated with the first test antenna location and the second set of Doppler frequency components into second bearing angle associated with the second antenna location; wherein the location of the one or more leakage antennas is determined as the locations where said first bearing angle from the first test antenna location intersect said second bearing angle from the second test antenna location.", "2.A system according to claim 1, further comprising a second mobile test antenna connected to second mobile receiver that produces a third set of I and Q samples which is processed to resolves left-right location ambiguity.", "3.A system according to claim 1, further comprising a second mobile test antenna and a switch connecting said first mobile test antenna and said second mobile test antenna to said receiver, the receiver alternately connecting the first mobile test antenna and the second mobile test antenna to the receiver.", "4.A system according to claim 1, further comprising changing test signal frequencies to determine the severity of the one or more leakage antennas.", "5.A system for detecting one or more leakage antennas that receive a first transmitted test signal, comprising: a mobile transmit antenna connected to the first transmitted test signal transmitter for transmitting the first transmitted test signal; a stationary receiver and processing unit connected to the one or more leakage antennas for receiving and processing mobile transmit antenna generated signals and producing a first and second set of I and Q samples as a result of said processing; a location processing unit for determining the location of a first test antenna location and a second test antenna location; and a Fourier transformer processing unit for converting the first set of I and Q samples into a first set of Doppler frequency components associated with the first test antenna location and converting the second set of I and Q samples into a second set of Doppler frequency components associated with the second test antenna location; and a bearing angle processing unit configured to convert of first set of Doppler frequency components into first bearing angle associated with the first test antenna location and the second set of Doppler frequency components into a second bearing angle associated with the second test antenna location; wherein the location of the leakage antenna is determined as the locations where said first bearing angles from first test antenna location intersect said second bearing angles from second test antenna location.", "6.A system according to claim 5, further comprising a second mobile transmit antenna which transmits a second transmitted test signal which is received at the one or more leakage antennas and stationary receiver and is processed by the processing unit to resolves left-right location ambiguity.", "7.A system according to claim 5, further comprising a data storage unit for recording leakage data.", "8.A system according to claim 7, wherein leakage data is automatically recorded when mobile transmit antenna is in a region with the first or second transmitted test signal, and data gathering is suspended when said mobile transmit antenna is outside the region with the first or second transmitted test signal.", "9.A system according to claim 1, further comprising a GPS data logger for associating latitude and longitude data with the one or more leakage antennas." ], [ "<SOH> BACKGROUND <EOH>Cable system operators use Radio Frequency (RF) signals transmitted over coaxial cables to provide television and data services to customers.", "Normally these RF signals do not cause interference when in compliance with Federal Communication Commission (FCC) rules that limit interference.", "However, in some cases the RF signals can leak.", "Cable signal leaks occur when the RF signals transmitted within the cable system are not contained within the cable plant.", "Cable signal leaks may be caused by loose connectors, damaged cables, unshielded housings, or unterminated cables.", "A cable plant uses many of the same frequencies to transmit programming as licensed to over-the-air broadcasters.", "Cable operators are considered by the FCC to be secondary users of these frequencies, so they are precluded from interfering with licensed users who are the primary users of these frequencies.", "Cable signal leakage can interfere with the over-the-air services that are using the same frequencies as the cable plant near the vicinity of an RF leak.", "This can interfere with ham radio operators, cellular radio, emergency responders, and aircraft navigation systems.", "When interference from the cable plant occurs, it can hamper or endanger others.", "The FCC has set maximum individual signal leakage levels for cable systems.", "The FCC is stricter with signal leakage levels for cable systems that interfere with aeronautical and/or navigation communications.", "Therefore, the FCC requires cable operators to have a periodic, on-going program to inspect, locate, and repair RF leaks in their cable plants.", "However, locating RF leaks in a cable plant can be difficult and time consuming, due to the complexity and size of a typical cable plant.", "Cable system operator use Radio Frequency (RF) signals transmitted over coaxial cables to provide television and data services to customers.", "Normally these RF signals do not cause interference when the shielding integrity is good, but sometime damage occurs.", "Damage may be caused by corrosion, animal chews, craft error, or mechanical stress.", "When there is damage to cable shielding, cable signals may leak out causing interference with wireless services.", "Many of the RF frequencies used inside the coaxial cable are the same frequencies used for a variety of wireless communication services, such as aviation signals, Ham radio signals, broadcast signals and wireless LTE (long term evolution) 2-way communications.", "Additionally, when there is shield damage allowing signal egress, it may be accompanied by signal ingress, where cable services are negatively affected by wireless signals or electrical noise.", "The FCC has published leakage limits for field strength.", "One limitation with legacy leakage detection equipment is that when a distance between the leakage signal's source and a receiving antenna is not known, it is not possible to calculate if the field strength exceeds FCC limits at a test distance, which may be at 3 meters or 30 meters.", "Thus, there is a need to know measurement distance to calculate if a detected leak exceeds FCC limits." ], [ "<SOH> SUMMARY <EOH>Embodiments described herein provide for the detection of RF leaks in a coaxial cable of a cable plant utilizing various analytical techniques that are applied to the RF signals emitted from the RF leaks.", "These analytical techniques provide information about an RF leak that reduces the amount of effort and time that may be required to locate the RF leak in the cable plant.", "One embodiment comprises a mobile device that is configured to detect RF leaks emanating from a coaxial cable of a cable plant.", "The mobile device includes an antenna that is configured to receive an RF signal from an RF leak in the coaxial cable.", "The mobile device further includes a quadrature demodulator that is configured to demodulate the RF signal to generate In-phase and Quadrature (IQ) data, and a controller.", "The controller is configured to determine changes in a phase angle of the RF signal based on the IQ data generated as the mobile device is in motion.", "The controller is further configured to identify that the mobile device is travelling toward the RF leak responsive to determining that the phase angle is advancing, and to identify that the mobile device is travelling away from the RF leak responsive to determining that the phase angle is retarding.", "Another embodiment comprises a method for detecting RF leaks emanating from a coaxial cable of a cable plant.", "The method comprises receiving, by an antenna of a mobile device, an RF signal from an RF leak in the coaxial cable.", "The method further comprises demodulating the RF signal to generate IQ data, and determining changes in a phase angle of the RF signal based on the IQ data generated as the mobile device is in motion.", "The method further comprises identifying that the mobile device is travelling towards the RF leak responsive to determining that the phase angle is advancing, and identifying that the mobile device is travelling away from the RF leak responsive to determining that the phase angle is retarding.", "Another embodiment is a non-transitory computer readable medium embodying programmed instructions which, when executed by a processor of a mobile device, detects RF leaks emanating from a coaxial cable of a cable plant.", "The instructions direct the processor to receive, by an antenna of the mobile device, an RF signal from an RF leak in the coaxial cable.", "The instructions further direct the processor to demodulate the RF signal to generate IQ data, and to determine changes in a phase angle of the RF signal based on the IQ data generated as the mobile device is in motion.", "The instructions further direct the processor to identify that the mobile device is traveling towards the RF leak responsive to determining that the phase angle is advancing.", "The instructions further direct the processor to identify that the mobile device is traveling away from the RF leak responsive to determining that the phase angle is retarding.", "The above summary provides a basic understanding of some aspects of the specification.", "This summary is not an extensive overview of the specification.", "It is intended to neither identify key or critical elements of the specification nor delineate any scope particular embodiments of the specification, or any scope of the claims.", "Its sole purpose is to present some concepts of the specification in a simplified form as a prelude to the more detailed description that is presented later.", "Embodiments described herein provide for the detection of RF leaks in coaxial network utilizing various analytical techniques that are applied to RF signals emitted from the RF leaks, or probing RF signals applied to the coaxial network to discover shielding defects.", "These analytical techniques provide information about shielding defects that reduce the amount on time and effort that may be required to locate and repair the shielding defect.", "In one embodiment a mobile test antenna receives a leakage test signal radiated from a leakage antenna created by a shield break in the cable plant.", "The antenna is connected to a mobile receiver with a complex demodulator producing in-phase (I) and quadrature (Q) samples periodically.", "I-Q samples, which contain information about the magnitude and phase of one or more leakage antennas, are inserted into a Fourier transform, which produce Doppler frequency components for each leakage antenna.", "The Doppler frequency components may each be processed with an arc cosine function to reveal bearing angles to each leakage antenna, as well as strength of the leakage signal.", "After the mobile antenna moves a distance, the intersection of another bearing angle with the first bearing angle reveals the position of the leaks.", "In another embodiment another embodiment a second mobile test antenna is used to resolve whether the leak is on the left or right side of the drive path.", "In another embodiment, a mobile transmit antenna, connected to a mobile test signal transmitter, transmits a leakage signal which is received by a leakage antenna and relayed over cable line to a stationary receiver.", "The position of the mobile transmit antenna during the test may be sent wirelessly to a stationary receiver, so the latitude and longitude of the leakage antennas can be determined.", "In another embodiment a second mobile transmitting antenna is used to resolve left-right ambiguity.", "In another embodiment a single antenna with a position reporting capability is moved by a technician, and I-Q field strength is recorded along with position as the antenna is moved.", "The result is a spatial map of electromagnetic field in a space that is analyzed for the leakage source." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS The present application is a continuation of U.S. application Ser.", "No.", "15/276,263 (filed Sep. 26, 2016) entitled “RADIO FREQUENCY LEAKAGE DETECTION IN A CABLE PLANT,” which application is a continuation in part of U.S. application Ser.", "No.", "14/812,916 (filed Jul.", "29, 2015) entitled “RADIO FREQUENCY LEAKAGE DETECTION IN A CABLE PLANT,” which application claims priority to, and thus the benefit of, an earlier filing date from, U.S.", "Provisional Patent Application No.", "62/030,345 (filed Jul.", "29, 2014) entitled “LOCATING/IDENTIFYING CABLE PLANT ISSUES”, U.S.", "Provisional Patent Application No.", "62/054,529 (filed Sep. 24, 2014) entitled “VARIOUS COMMUNICATION SYSTEMS AND METHODS”, and U.S.", "Provisional Patent Application No.", "62/146,848 (filed on Apr.", "13, 2015) entitled “SIGNAL LEAKAGE DETECTION USING SYNTHETIC PHASED ARRAYS”, all of which are hereby incorporated by reference.", "FIELD This disclosure relates to the field of Radio Frequency (RF) signal detection, and in particular, to detecting RF leaks from a cable plant of a cable system operator.", "BACKGROUND Cable system operators use Radio Frequency (RF) signals transmitted over coaxial cables to provide television and data services to customers.", "Normally these RF signals do not cause interference when in compliance with Federal Communication Commission (FCC) rules that limit interference.", "However, in some cases the RF signals can leak.", "Cable signal leaks occur when the RF signals transmitted within the cable system are not contained within the cable plant.", "Cable signal leaks may be caused by loose connectors, damaged cables, unshielded housings, or unterminated cables.", "A cable plant uses many of the same frequencies to transmit programming as licensed to over-the-air broadcasters.", "Cable operators are considered by the FCC to be secondary users of these frequencies, so they are precluded from interfering with licensed users who are the primary users of these frequencies.", "Cable signal leakage can interfere with the over-the-air services that are using the same frequencies as the cable plant near the vicinity of an RF leak.", "This can interfere with ham radio operators, cellular radio, emergency responders, and aircraft navigation systems.", "When interference from the cable plant occurs, it can hamper or endanger others.", "The FCC has set maximum individual signal leakage levels for cable systems.", "The FCC is stricter with signal leakage levels for cable systems that interfere with aeronautical and/or navigation communications.", "Therefore, the FCC requires cable operators to have a periodic, on-going program to inspect, locate, and repair RF leaks in their cable plants.", "However, locating RF leaks in a cable plant can be difficult and time consuming, due to the complexity and size of a typical cable plant.", "Cable system operator use Radio Frequency (RF) signals transmitted over coaxial cables to provide television and data services to customers.", "Normally these RF signals do not cause interference when the shielding integrity is good, but sometime damage occurs.", "Damage may be caused by corrosion, animal chews, craft error, or mechanical stress.", "When there is damage to cable shielding, cable signals may leak out causing interference with wireless services.", "Many of the RF frequencies used inside the coaxial cable are the same frequencies used for a variety of wireless communication services, such as aviation signals, Ham radio signals, broadcast signals and wireless LTE (long term evolution) 2-way communications.", "Additionally, when there is shield damage allowing signal egress, it may be accompanied by signal ingress, where cable services are negatively affected by wireless signals or electrical noise.", "The FCC has published leakage limits for field strength.", "One limitation with legacy leakage detection equipment is that when a distance between the leakage signal's source and a receiving antenna is not known, it is not possible to calculate if the field strength exceeds FCC limits at a test distance, which may be at 3 meters or 30 meters.", "Thus, there is a need to know measurement distance to calculate if a detected leak exceeds FCC limits.", "SUMMARY Embodiments described herein provide for the detection of RF leaks in a coaxial cable of a cable plant utilizing various analytical techniques that are applied to the RF signals emitted from the RF leaks.", "These analytical techniques provide information about an RF leak that reduces the amount of effort and time that may be required to locate the RF leak in the cable plant.", "One embodiment comprises a mobile device that is configured to detect RF leaks emanating from a coaxial cable of a cable plant.", "The mobile device includes an antenna that is configured to receive an RF signal from an RF leak in the coaxial cable.", "The mobile device further includes a quadrature demodulator that is configured to demodulate the RF signal to generate In-phase and Quadrature (IQ) data, and a controller.", "The controller is configured to determine changes in a phase angle of the RF signal based on the IQ data generated as the mobile device is in motion.", "The controller is further configured to identify that the mobile device is travelling toward the RF leak responsive to determining that the phase angle is advancing, and to identify that the mobile device is travelling away from the RF leak responsive to determining that the phase angle is retarding.", "Another embodiment comprises a method for detecting RF leaks emanating from a coaxial cable of a cable plant.", "The method comprises receiving, by an antenna of a mobile device, an RF signal from an RF leak in the coaxial cable.", "The method further comprises demodulating the RF signal to generate IQ data, and determining changes in a phase angle of the RF signal based on the IQ data generated as the mobile device is in motion.", "The method further comprises identifying that the mobile device is travelling towards the RF leak responsive to determining that the phase angle is advancing, and identifying that the mobile device is travelling away from the RF leak responsive to determining that the phase angle is retarding.", "Another embodiment is a non-transitory computer readable medium embodying programmed instructions which, when executed by a processor of a mobile device, detects RF leaks emanating from a coaxial cable of a cable plant.", "The instructions direct the processor to receive, by an antenna of the mobile device, an RF signal from an RF leak in the coaxial cable.", "The instructions further direct the processor to demodulate the RF signal to generate IQ data, and to determine changes in a phase angle of the RF signal based on the IQ data generated as the mobile device is in motion.", "The instructions further direct the processor to identify that the mobile device is traveling towards the RF leak responsive to determining that the phase angle is advancing.", "The instructions further direct the processor to identify that the mobile device is traveling away from the RF leak responsive to determining that the phase angle is retarding.", "The above summary provides a basic understanding of some aspects of the specification.", "This summary is not an extensive overview of the specification.", "It is intended to neither identify key or critical elements of the specification nor delineate any scope particular embodiments of the specification, or any scope of the claims.", "Its sole purpose is to present some concepts of the specification in a simplified form as a prelude to the more detailed description that is presented later.", "Embodiments described herein provide for the detection of RF leaks in coaxial network utilizing various analytical techniques that are applied to RF signals emitted from the RF leaks, or probing RF signals applied to the coaxial network to discover shielding defects.", "These analytical techniques provide information about shielding defects that reduce the amount on time and effort that may be required to locate and repair the shielding defect.", "In one embodiment a mobile test antenna receives a leakage test signal radiated from a leakage antenna created by a shield break in the cable plant.", "The antenna is connected to a mobile receiver with a complex demodulator producing in-phase (I) and quadrature (Q) samples periodically.", "I-Q samples, which contain information about the magnitude and phase of one or more leakage antennas, are inserted into a Fourier transform, which produce Doppler frequency components for each leakage antenna.", "The Doppler frequency components may each be processed with an arc cosine function to reveal bearing angles to each leakage antenna, as well as strength of the leakage signal.", "After the mobile antenna moves a distance, the intersection of another bearing angle with the first bearing angle reveals the position of the leaks.", "In another embodiment another embodiment a second mobile test antenna is used to resolve whether the leak is on the left or right side of the drive path.", "In another embodiment, a mobile transmit antenna, connected to a mobile test signal transmitter, transmits a leakage signal which is received by a leakage antenna and relayed over cable line to a stationary receiver.", "The position of the mobile transmit antenna during the test may be sent wirelessly to a stationary receiver, so the latitude and longitude of the leakage antennas can be determined.", "In another embodiment a second mobile transmitting antenna is used to resolve left-right ambiguity.", "In another embodiment a single antenna with a position reporting capability is moved by a technician, and I-Q field strength is recorded along with position as the antenna is moved.", "The result is a spatial map of electromagnetic field in a space that is analyzed for the leakage source.", "DESCRIPTION OF THE DRAWINGS Some embodiments are now described, by way of example only, and with reference to the accompanying drawings.", "The same reference number represents the same element or the same type of element on all drawings.", "FIG.", "1 is a block diagram of a mobile device that detects RF leaks emanating from a coaxial cable of a cable plant in an exemplary embodiment.", "FIG.", "2 is flow chart of a method for detecting RF leaks emanating from a coaxial cable of a cable plant in an exemplary embodiment.", "FIG.", "3 is a flow chart of another method for detecting an RF leak emanating from a coaxial cable plant in an exemplary embodiment.", "FIG.", "4 illustrates a first spatial cone along an x-axis in an exemplary embodiment.", "FIG.", "5 is a flow chart of a method of determining a bearing to an RF leak emanating from a coaxial cable of a cable plant in an exemplary embodiment.", "FIG.", "6 illustrates a second spatial cone along a y-axis in an exemplary embodiment.", "FIG.", "7 illustrates two possible bearings to an RF leak in an exemplary embodiment.", "FIG.", "8 illustrates a third spatial cone along a z-axis in an exemplary embodiment.", "FIG.", "9 illustrates the mobile device of FIG.", "1 in another exemplary embodiment.", "FIG.", "10 is a flow chart of another method for determining a bearing to an RF leak emanating from a coaxial cable of a cable plant in an exemplary embodiment.", "FIG.", "11 is a flow chart of a method for determining if multiple RF leaks exist in a coaxial cable of a cable plant in an exemplary embodiment.", "FIG.", "12 is a block diagram of the mobile device of FIG.", "1 in another exemplary embodiment.", "FIG.", "13 is a flow chart of another method for detecting RF leaks emanating from a coaxial cable of a cable plant in an exemplary embodiment.", "FIG.", "14 is a block diagram of the mobile device of FIG.", "1 in another exemplary embodiment.", "FIG.", "15 illustrates spatial cones that are not located at the origin in an exemplary embodiment.", "FIG.", "16 is a block diagram of an exemplary computing system in which a computer readable medium provides instructions for performing the methods described herein.", "FIG.", "17 illustratively represents a system utilizing a single receive antenna for locating leakage antennas, in an embodiment.", "FIG.", "18 illustratively represents a system utilizing a two transmit antennas for locating leakage antennas, in an embodiment.", "FIG.", "19 is a diagram showing two Doppler frequency vs. distance plots to determine if leak is on the left or right, in an embodiment.", "FIG.", "20 illustratively represents moving an antenna in a space to determine from the mapped electromagnetic field in that space where leakage antennas are located, in an embodiment.", "DESCRIPTION The figures and the following description illustrate specific exemplary embodiments.", "It will thus be appreciated that those skilled in the art will be able to devise various arrangements that, although not explicitly described or shown herein, embody the principles of the embodiments and are included within the scope of the embodiments.", "Furthermore, any examples described herein are intended to aid in understanding the principles of the embodiments, and are to be construed as being without limitation to such specifically recited examples and conditions.", "As a result, the inventive concept(s) is not limited to the specific embodiments or examples described below, but by the claims and their equivalents.", "FIG.", "1 is a block diagram of a mobile device 100 that detects RF leaks emanating from a coaxial cable of a cable plant in an exemplary embodiment.", "For purposes of discussion, a coaxial cable 102 is illustrated in FIG.", "1 that is part of a cable plant.", "Coaxial cable 102 includes an inner conductor (not shown) that is surrounded by a tubular insulation layer (not shown).", "The tubular insulation layer is surrounded by a tubular outer shield (not shown).", "In this embodiment, coaxial cable 102 is utilized by a cable operator to distribute television and/or data services to customers.", "Cable operators typically transmit using some of the same frequencies over coaxial cables (e.g., coaxial cable 102) that are licensed for over-the-air broadcasts.", "For instance, a cable plant may utilize frequencies of up to about 1 gigahertz (GHz), which may interfere (if there are RF leaks) with any number of critical radio services in the US, such as local fire departments (154.28 MHz), local and state search and rescue (155.160 MHz), National Guard (163.4875 MHz), the US Air Force (311.00 MHz), and many others.", "To prevent the cable plant from interfering with licensed spectrum, the FCC requires that cable operators routinely inspect their cable plants to determine if any RF leaks are present.", "For purposes of discussion, coaxial cable 102 in FIG.", "1 is illustrated with an RF leak 104 that is detectable by mobile device 100.RF leak 104 may be caused by damage to coaxial cable 102.Some examples of the types of damage that may occur at coaxial cable 102 include broken tubular outer shields, loose connectors, damaged RF gaskets on housings, etc.", "In this embodiment RF leak 104 generates an RF signal 110, which corresponds with an RF test signal 106 that is transmitted along coaxial cable 102.RF test signal 106 may be a Continuous Wave (CW) test signal in some embodiments.", "For instance, RF test signal 106 may be an 800 megahertz (MHz) CW signal that is injected along coaxial cable 102 to allow mobile device 100 to detect RF leak 104.However, 800 MHz is just one possible frequency that may be transmitted along coaxial cable 102, with other options being any frequency that may be supported by the bandwidth of coaxial cable 102.In some embodiments, RF test signal 106 may include pilot signals that are used for automatic gain and slope control of data signals transmitted by coaxial cable 102.RF test signal 106 may also include data signals utilized by a cable plant to provide television and/or data services to customers in some embodiments.", "In this embodiment, mobile device 100 includes an antenna 108 that is capable of receiving RF signal 110 that is generated by RF leak 104.Antenna 108 includes any electrical device that is able to convert RF signal 110 into an electrical current and/or voltage.", "Mobile device 100 also includes a quadrature demodulator (QD) 112, that generates IQ data 114.Quadrature demodulation is sometimes referred to as IQ demodulation, or complex demodulation.", "QD 112 demodulates RF signal 110, and generates both an in-phase component (I) and a quadrature component (Q) of RF signal 110 relative to a frequency source (not shown) used for demodulation.", "For instance, if RF test signal 106 is a 800 MHz CW test signal, then the QD 112 may utilize an 800 MHz frequency source to demodulate RF signal 110 and generate IQ data 114, which would represent changes in the phase and magnitude of RF signal 110.QD 112 in this embodiment includes any electronic device that is able to demodulate RF signal 110, and to generate both an in-phase and a quadrature component for RF signal 110.IQ data 114 is proved to a controller 116, which is able to analyze IQ data 114 to enable mobile device 100 to detect information about RF leak 104.For instance, controller 116 may be able to analyze IQ data 114 to identify whether mobile device 110 is moving toward or away from RF leak 104, may be able to analyze IQ data 114 to determine a bearing and/or a location of RF leak 104, may be able to analyze IQ data 114 to identify frequency shifts in RF signal 110 etc.", "To do so, controller 116 may utilize any electronic device that is capable of performing such functionality.", "While the specific hardware implementation of controller 116 is subject to design choices, one particular embodiment may include one or more processors 118 coupled with a memory 120.Processor 118 includes any electronic device that is able to perform functions.", "Processor 118 may include one or more Central Processing Units (CPU), microprocessors, Digital Signal Processors (DSPs), Application-specific Integrated Circuits (ASICs), etc.", "Some examples of processors include Intel® Core™ processors, ARM® processors, etc.", "Memory 120 includes any electronic device that is able to store data.", "For instance, memory 120 may store IQ data 114 during processing.", "Memory 120 may include one or more volatile or non-volatile Dynamic Random Access Memory (DRAM) devices, FLASH devices, volatile or non-volatile Static RAM devices, hard drives, Solid State Disks (SSDs), etc.", "Some examples of non-volatile DRAM and SRAM include battery-backed DRAM and battery-backed SRAM.", "Mobile device 100 in some embodiments includes a display 122, which allows a user (not shown in FIG.", "1) to interact visually with mobile device 100.Display 122 includes any electronic device that is capable of displaying information to a user.", "One example of display 122 includes a Liquid Crystal Display (LCD), which may include a touch interface that allows the user to control mobile device 100.Consider that a user is in the field with mobile device 100, and is attempting to locate RF leak 104 in coaxial cable 102.RF test signal 106 is transmitted along coaxial cable 102 during the testing process.", "RF test signal 106 may be introduced at a downstream portion of the cable plant relative to coaxial cable 102, may include pilot or training signals utilized by the cable plant, and/or may include data signals provided by the cable plant to customers.", "FIG.", "2 is flow chart of a method 200 for detecting RF leaks emanating from a coaxial cable of a cable plant in an exemplary embodiment.", "Method 200 will be discussed with respect to mobile device 100, although method 200 may be performed by other systems, not shown.", "The steps of the flow charts described herein may include other steps that are not shown.", "Also, the steps of the flow charts described herein may be performed in an alternate order.", "Mobile device 100 begins the testing phase of coaxial cable 102 by receiving RF signal 110 at antenna 108 (see step 202 of FIG.", "2).", "To do so, a user may carry mobile device 100 proximate to coaxial cable 102, a user may be driving nearby coaxial cable 102 with mobile device 100 in a vehicle, etc.", "The RF signal 110 is demodulated by QD 112 to generate IQ data 114, which is provided to processor 118 of controller 116.In some embodiments, RF test signal 106 may comprise a CW test signal at a known frequency.", "In this case, QD 112 may use a reference source at the known frequency to demodulate RF signal 110, with IQ data 114 representing the in-phase (I) and quadrature (Q) differences between RF signal 110 and the source.", "In other embodiments, RF test signal 106 may comprise a broadband test signal having a pre-determined pattern.", "For instance, RF test signal 106 may comprise pre-defined Orthogonal Frequency Division Multiplexed (OFDM) test patterns, such as pilot subcarriers used in Data Over Cable Service Interface Specification (DOSCIS®) used by a customer's cable modem to adapt to changing channel conditions.", "Processor 118 analyzes IQ data 114, and determines changes in a phase angle of RF signal 110 generated as mobile device 100 is in motion (see step 206).", "For instance, processor 118 may monitor changes in the phase angle as the user carries mobile device 100 along coaxial cable 102.Changes to the phase angle result from mobile device 100 moving with respect to RF leak 104.For instance, if RF test signal 106 is an 800 MHz CW signal, then a wavelength of RF signal 110 generated by RF leak 104 is about 37.5 centimeters (cm).", "As mobile device 100 is moved closer to RF leak 104, the phase angle of RF signal 110 advances.", "For example, if mobile device 100 is moved 10 cm directly towards RF leak 104, then processor 118 would be able to determine that the phase angle of RF signal 110 advances by about (10/37.5)*360 degrees, or about 96 degrees.", "In like manner, if mobile device 100 is moved 10 cm directly away from RF leak 104, then processor 118 would be able to determine that the phase angle of RF signal 110 is retarding by about 96 degrees.", "However, it is not necessary that mobile device 100 be traveling directly toward or away from RF leak 104 in order to identify changes in the phase angle of RF signal 110.If processor 118 determines that the phase angle of RF signal 110 is retarding, then processor 118 will identify that mobile device 100 is traveling away from RF leak 104 (see step 208).", "For instance, processor 118 may indicate such on display 122 in some embodiments.", "If processor 118 determines that the phase angle of RF signal 110 is advancing, then processor 118 will identify that mobile device 100 is traveling towards RF leak 104 (see step 210).", "For instance, processor 118 may indicate such on display 122 in some embodiments.", "Accurately identifying small changes in the phase angle of RF signal 110 may depend upon a number of factors, including the stability of the frequency of RF test signal 106, the stability of the source frequency used by QD 112 to demodulate RF signal 110, etc.", "Therefore, mobile device 100 may include a highly stable frequency source.", "For instance, mobile device 100 may include a Rubidium-based frequency standard and/or an oscillator locked to a Global Positioning System (GPS) signal, which may be used by QD 112 to demodulate RF signal 110.FIG.", "3 is a flow chart of another method 300 of detecting an RF leak emanating from a coaxial cable plant in an exemplary embodiment.", "Method 300 will be discussed with respect to mobile device 100, although method 300 may be performed by other systems, not shown.", "In this embodiment, information about RF leak 104 can be determined by determining phase changes in RF signal 110 when mobile device 100 changes locations and constraining possible bearings to RF leak 104 based on a relationship between changes in the phase angle and the distance between the locations.", "Consider that mobile device 100 is located at a first location, which for purposes of discussion is the origin (0,0) of an x-y coordinate system.", "Starting at the origin, if mobile device 100 is moved along the x-axis a small incremental amount Δx, then an angle θ1 can be computed which will describe a first spatial cone along the x-axis in 3-dimensions.", "An apex angle of the first spatial cone will be twice θ1, and will be at the origin.", "θ1 is calculated based on a relationship between the actual phase change of RF signal 110 between (0,0) and (0+Δx, 0), and the phase change that would be expected if mobile device 100 was moved directly towards RF leak 104.Processor 118 analyzes IQ data 114 generated at a first location (0,0) to determine a first phase angle of RF signal 110 based on IQ data 114 generated at the first location (see step 302 of FIG.", "3).", "Mobile device 100 is moved to a second location (0+Δx, 0), and processor 118 determines a second phase angle of RF signal 110 based on IQ data 114 generated at the second location (see step 304).", "The distance between the origin (0,0) and (0+Δx, 0) can be determined by mobile device 100 (e.g., utilizing an accelerometer, GPS signals, etc.", "), and used to calculate an expected phase shift in RF signal 110 that would occur if RF leak 104 were located along the x-axis.", "For instance, if RF test signal 106 is an 800 MHz CW test signal, then the wavelength would be 37.5 cm.", "Therefore, one would expect that if mobile device 100 was moved 37.5 cm along the x-axis, that a phase rotation between the first phase determined at (0,0) and the second phase determined at (0+Δx, 0) would be 360 degrees.", "If the phase difference between (0,0) and (0+Δx, 0) were instead only 270 degrees, then θ1 is related to 270/360.In particular, θ1 may be calculated as the Arc cosine of (270/360), which is 41.4 degrees.", "The apex angle of the first spatial cone is therefore 2 θ1, or 82.8 degrees, which is calculated based on the phase difference and the distance between the first location and the second location (see step 306).", "A first spatial cone 402 is illustrated in FIG.", "4, which is located at (0,0) and lies along the x-axis.", "The apex angle for first spatial cone 402 is 2 θ1, and RF leak 104 lies along a surface generated by first spatial cone 402.Fist spatial cone 402 therefore confines possible locations of RF leak 104 to its surface.", "Similar calculation can be performed along the y-axis to generate a second spatial cone and the z-axis to generate a third spatial cone that further constrains the possible locations of RF leak 104.FIG.", "5 is a flow chart of a method 500 of determining a bearing to an RF leak emanating from a coaxial cable of a cable plant in an exemplary embodiment.", "Method 500 will be discussed with respect to mobile device 100, although method 500 may be performed by other systems, not shown.", "Starting at the origin (0,0), if mobile device 100 is moved along the vertical y-axis a small incremental amount Δy, then an angle θ2 can be computed which will describe a second spatial cone along the y-axis in 3-dimensions.", "An apex angle of the second spatial cone will be twice θ2, and will be at the origin.", "θ2 is calculated based on a relationship between the actual phase change of RF signal 110 between (0,0) and (0, 0+Δy), and the phase change that would be expected if mobile device 100 was moved directly towards RF leak 104.In this embodiment, the y-axis is orthogonal to the x-axis, and the second spatial cone further constrains possible locations of RF leak 104 along a surface of the second spatial cone.", "Mobile device 100 is moved to a third location (0, 0+Δy), and processor 118 determines a third phase angle of RF signal 110 based on of IQ data 114 at the third location (see step 502).", "The distance between the origin (0,0) and (0, 0+Δy) can be determined by mobile device 100, and used to calculate an expected phase shift in RF signal 110 that would occur if RF leak 104 were located along the y-axis.", "For instance, if RF test signal 106 is an 800 MHz CW test signal, then the wavelength would be 37.5 cm.", "Therefore, one would expect that if mobile device 100 was moved 37.5 cm along the y-axis, that a phase rotation between the first phase determined at (0,0) and the second phase determined at (0, 0+Δy) would be 360 degrees.", "If the phase difference between (0,0) and (0, 0+Δy) were instead only 200 degrees, then θ2 is related to 200/360.In particular, θ2 may be calculated as the Arc cosine of (200/360), which is 56.3 degrees.", "The apex angle of the second spatial cone is therefore 2 θ2, or 102.6 degrees, which is calculated based on the phase difference and the distance between the first location and the third location (see step 504).", "A second spatial cone 602 is illustrated in FIG.", "6.The apex angle for second spatial cone 602 is 2 θ2.Using the apex angles calculated for first spatial cone 402 and second spatial cone 602, processor 118 is able to determine bearings to RF leak 104 that are based on the intersection between first spatial cone 402 and second spatial cone 602, which occurs along lines 604-605 in FIG.", "6.A bearing to RF leak 104 will lie on one of lines 604-605.Processor 118 may indicate bearings to RF leak 104 on display 122 in some embodiments.", "If the elevation along a z-axis of RF leak 104 is known, then the elevation may be used to determine which lines 604-605 are the correct bearing.", "If the elevation along the z-axis of RF leak 104 is not known, then which of lines 604-605 is the correct bearing to RF leak 104 can be calculated using similar techniques as described above for the x-axis and y-axis spatial cones along the z-axis.", "Consider that mobile device 100 is located at the first location, which is the origin (0,0,0) of an x-y-z coordinate system illustrated in FIG.", "7.FIG.", "7 illustrates two possible bearings to an RF leak in an exemplary embodiment.", "First spatial cone 402 and second spatial cone 602 have been removed for clarity, leaving behind lines 604-605 that represent possible bearings to RF leak 104.Starting at the origin, if mobile device 100 is moved along the z-axis a small incremental amount Δz, then an angle θ3 can be computed which will describe a third spatial cone along the z-axis in 3-dimensions.", "An apex angle of the third spatial cone will be twice θ3, and will be at the origin.", "θ3 is calculated based on a relationship between the actual phase change of RF signal 110 between (0,0,0) and (0,0,0+Δz), and the phase change that would be expected if mobile device 100 was moved directly towards RF leak 104.In this embodiment, the z-axis is orthogonal to both the x-axis and the y-axis, and the third spatial cone further constrains possible locations of RF leak 104 along a surface of the third spatial cone.", "Mobile device 100 is moved to a third location (0,0,0+Δz), and processor 118 determines a fourth phase angle of RF signal 110 based on IQ data 114 at the third location (see step 506 of FIG.", "5).", "The distance between the origin (0,0,0) and (0,0,0+Δz) can be determined by mobile device 100, and used to calculate an expected phase shift in RF signal 110 that would occur if RF leak 104 were located along the z-axis.", "For instance, if RF test signal 106 is an 800 MHz CW test signal, then the wavelength would be 37.5 cm.", "Therefore, one would expect that if mobile device 100 was moved 37.5 cm along the x-axis, that a phase rotation between the first phase determined at (0,0,0) and the fourth phase determined at (0,0,0+Δz) would be 360 degrees.", "If the phase difference between (0,0,0) and (0,0,0+Δz) were instead only 250 degrees, then θ3 is related to 250/360.In particular, θ3 may be calculated as the Arc cosine of (250/360), which is 46 degrees.", "The apex angle of the third spatial cone is therefore 2 θ3, or 92 degrees, which is calculated based on the phase difference and the distance between the first location and the fourth location (see step 508).", "A third spatial cone 802 is illustrated in FIG.", "8, which is located at (0,0,0) and lies along the z-axis.", "The apex angle for third spatial cone 802 is 2 θ3, and processor 118 determines line 604 is a bearing of RF leak 104 based on an intersection 804 between first spatial cone 402, second spatial cone 602, and third spatial cone 802 (see step 510).", "Processor 118 may indicate the bearing on display 122 of mobile device 100 in some embodiments.", "FIG.", "9 illustrates mobile device 100 in another exemplary embodiment.", "In this embodiment, mobile device 100 includes a member 902 that is configured to rotate about an axis 904.In this embodiment, antenna 108 is mounted to member 902 at a radius 906 from axis 904, and rotates about axis 904 as member 902 rotates.", "As antenna 108 rotates in the direction indicated in the arrow in FIG.", "9, a phase angle 908 of RF signal 110 advances and retards.", "FIG.", "10 is a flow chart of another method 1000 for determining a bearing to an RF leak emanating from a coaxial cable of a cable plant in another exemplary embodiment.", "Processor 118 determines a maximum rate of change (e.g., the first derivative) of phase angle 908 that is generated as antenna 108 rotates about axis 904 (see step 1002 of FIG.", "10).", "A bearing angle θb of RF leak 104 can be determined by processor 118 based on a position of antenna 108 at the maximum rate of change as member 902 rotates (see step 1004).", "A tangent from the direction of rotation at point B, where the slope of phase 908 is at a maximum, can be determined from θb.", "Tangent point A will be 180 degrees opposed.", "A bearing from mobile device 100 to RF leak 104 may be indicated on display 122 by processor 118 in some embodiments.", "In Another embodiment, mobile device 100 performs an Inverse Fast Fourier Transform (IFFT) on IQ data 114 to generate IFFT data, and attempts to determine if multiple RF leaks are present in coaxial cable 102.FIG.", "11 is a flow chart of a method 1100 for determining if multiple RF leaks exist in a coaxial cable of a cable plant in an exemplary embodiment.", "In this embodiment, RF test signal 106 is a wideband RF signal.", "Some other examples of RF test signal 106 include chirps, sin(x)/x waveforms, pseudo-noise sequences, and Zadoff-Chu sequences.", "During operation, processor 118 performs an IFFT on samples of IQ data 114 to generate IFFT data (see step 1102).", "Processor 118 determines if at least two RF sources are indicated in the IFFT data (see step 1104).", "If only one RF source is indicated, then method 1100 ends.", "If at least two RF sources are indicated, then processor 118 determines if a phase of each of the RF sources corresponds as mobile device 100 changes locations (see step 1106).", "Even if two RF sources are identified in the IFFT data, one RF source may be a reflection of another RF source.", "If the phases correspond, then processor determines that only one RF leak exists in coaxial cable 102 (see step 1108).", "However, if the phases do not correspond, then processor 118 determines that at least two RF leaks exist in coaxial cable 102 (see step 1110).", "In some embodiments, RF test signal 106 may DOCSIS® pilot signals that are typically transmitted by coaxial cable 102 while providing television and/or data services to customers.", "The pilot signals do not carry data, and are utilized to characterize the RF channel in coaxial cable 102.In another embodiment, mobile device 100 captures a full set of pilot subcarrier signals at the subcarrier frequencies of the pilot signals, and combines the pilot signals into an OFDM frame.", "Processor 118 is then able to perform an IFFT on IQ data 114 for the OFDM frame, which generates one or more impulse responses.", "If the impulses are the result of two or more RF leaks in coaxial cable 102, or the leaks have multipath issues, then the delays of the different impulses will vary from each other as mobile device 100 changes locations.", "If the delay changes of the individual impulses are tracked as the antenna is moved, each leak can be individually identified and a spatial cone may be created for each leak.", "FIG.", "12 is a block diagram of mobile device 100 in another exemplary embodiment.", "In this embodiment, mobile device 100 is able to process IQ data 114 while mobile device 100 is in motion, and determine changes in a frequency 1202 of RF signal 110.For instance, mobile device 100 may be placed in a vehicle, and driven along a road that is proximate to coaxial cable 102.Changes in frequency 1202 provide information to mobile device 100 regarding whether mobile device 100 is traveling toward RF leak 104 or away from RF leak 104.In this embodiment, RF test signal 106 is a test signal at a known frequency.", "FIG.", "13 is a flow chart of another method 1300 for detecting RF leaks emanating from a coaxial cable of a cable plant in an exemplary embodiment.", "Processor 118 determines changes in frequency 1202 of RF signal 110 as mobile device 100 is in motion (see step 1302).", "If frequency 1202 of RF signal 110 is higher than the known frequency of RF test signal 106, then processor 118 identifies that that mobile device 100 is traveling towards RF leak 104 (see step 1304).", "If frequency 1202 of RF signal 110 is lower than the predetermined frequency of RF test signal 106, then processor 118 identifies that mobile device 100 is traveling away from RF leak 104 (see step 1306).", "A distance 1212 between mobile device 100 and RF leak 104 may be estimated in some embodiments based on the rate at which frequency 1202 transitions.", "For example, using a slope of frequency 1202 in transition region 1204.The slope may be higher as distance 1212 decreases.", "In another embodiment, mobile device 100 is capable identifying a bearing towards RF leak 104 based on a transition region 1204 of frequency 1302 of RF signal 110.As mobile device 100 transitions from travelling toward RF leak 104 to travelling away from RF leak 104, frequency 1204 of RF signal 110 changes from being higher than the known frequency of RF test signal 106 to being lower than the known frequency of RF test signal 106.Transition region 1204 can be analyzed by processor 118 to identify a bearing towards RF leak 104.In this case, a zero crossing point 1206 allows processor 118 to identify a bearing 1208 to RF leak 104 that may be orthogonal to a direction of travel 1210 of mobile device.", "Using multiple bearings as mobile device 100 travels in different directions, an intersection of the multiple bearings indicates to mobile device 100 a location of RF leak 104.FIG.", "14 is a block diagram of mobile device 100 in another exemplary embodiment.", "In this embodiment, mobile device 100 is able to identify a location of RF leak 104 by analyzing an absolute delay between the transmission of RF test signal 106 and the reception of RF signal 110 by mobile device.", "As antenna 108 of mobile device 100 is brought closer to RF leak 104, a phase angle 1402 of RF signal 110 decreases to a minimum value at point 1404, which indicates that antenna 108 of mobile device 100 is proximate to RF leak 104.In another embodiment, mobile device 100 is capable of detecting information about RF leaks utilizing multiple spatial cones that are not located at the origin, which is illustrated in FIG.", "15.In this embodiment, spatial cone 1502 is located along the y-axis, and spatial cone 1504 is located along the x-axis.", "However, spatial cone 1504 is not located at the origin (0,0) in this embodiment.", "Rather, spatial cone 1504 is located some distance (d) along the x-axis from the origin, which places a location of RF leak 104 somewhere on a circle that is created when spatial cone 1502 intersects spatial cone 1504.In this embodiment, θ4 and θ5 are different angles.", "As discussed previously, an accurate source clock onboard mobile device 100 may be utilized in order to accurately identify subtle changes in the phase angle and/or the frequency of RF signal 110.One of the challenges in leakage detection is the use of a very stable reference signal source.", "This may be provided by using a Rubidium-based or Cesium-based frequency standard, which are commercially available.", "Another approach is the use a GPS-referenced clock.", "These challenges may be mitigated by transmitting an RF test signal with a built-in reference.", "One option includes the use of two CW RF test signals separated by a fixed frequency, such as 10 MHz.", "Other options include the use of modulation, such as Amplitude Modulation (AM) or Binary Phase Shift Keying (BPSK), or downstream DOCSIS® 3.1 signals which can have a bandwidth nearing 200 MHz.", "At mobile device 100, the RF signals could be demodulated to derive the clock, which would be used to as a reference for mobile device 100.If two tones were used, they could be mixed together to produce a lower stable reference.", "The current Ettus B200 Software Defined Radio (SDR) receiver uses a 10 MHz reference.", "The recovered symbol clock or difference frequency can be used to lock-up a phased lock loop (PLL) generating a stable 10 MHz.", "Using RF test signals with a built-in reference works even when there is Doppler shift, because the frequency of the modulation is not strongly affected by Doppler.", "Instead, the center frequency will be affected.", "Ideally you want the modulated signal, or two CW RF test signals, to be close enough in frequency to have very similar transmission path characteristics.", "One possible range for the recovered clock is 0.1-200 MHz.", "After recovering a stable clock, either or both tones can be demodulated into IQ data samples.", "The stable clock may also be derived from a data signal, such as a DOCSIS 3.1 OFDM® downstream signal.", "A problem arises when there is more than one signal source, or one signal source is reflecting and producing multipath.", "In this RF environment the trajectory of the IQ plot is no longer circular, but appears to move randomly, sometimes temporarily passing through the origin at a location where all received signals cancel due to vector phase addition or subtraction.", "The presence of multiple sources and be detected by measuring and saving IQ values at uniform distances while the antenna is traveling in a straight line.", "Mobile device 100 may perform Fourier transform such as a Discrete Fourier Transform (DFT) or a FFT on saved IQ data 114 to generate transformed data, which may reveal if multiple RF leaks or reflections are present.", "Ideally the samples are evenly spaced and the numbers of samples is 2 raised to an integer power, and all sample locations taken while antenna 108 is traveling in a straight line.", "Optionally the set of samples may be windowed to reduce a characteristic called leakage.", "After windowing the data set is transformed using a DFT.", "The data are analyzed and more data is gathered.", "If, for example a 64 point Fourier transform is being performed, a smoother display can be obtained by replacing some of the older samples with newer samples.", "Use of a windowing technique before performing a Fourier transform reduces leakage and produces clearer peaks in the transform.", "This test method may be viewed as a type of synthetic phased array.", "Utilizing the various analytical techniques described, locating and mitigating RF leaks in coaxial cables of a cable plant can be performed more quickly and efficiently.", "This allows the cable operator of the cable plant to unsure that the RF leakage levels enforced by the FCC are in compliance.", "Any of the various elements shown in the figures or described herein may be implemented as hardware, software, firmware, or some combination of these.", "For example, an element may be implemented as dedicated hardware.", "Dedicated hardware elements may be referred to as “processors”, “controllers”, or some similar terminology.", "When provided by a processor, the functions may be provided by a single dedicated processor, by a single shared processor, or by a plurality of individual processors, some of which may be shared.", "Moreover, explicit use of the term “processor” or “controller” should not be construed to refer exclusively to hardware capable of executing software, and may implicitly include, without limitation, digital signal processor (DSP) hardware, a network processor, application specific integrated circuit (ASIC) or other circuitry, field programmable gate array (FPGA), read only memory (ROM) for storing software, random access memory (RAM), non-volatile storage, logic, or some other physical hardware component or module.", "Also, an element may be implemented as instructions executable by a processor or a computer to perform the functions of the element.", "Some examples of instructions are software, program code, and firmware.", "The instructions are operational when executed by the processor to direct the processor to perform the functions of the element.", "The instructions may be stored on storage devices that are readable by the processor.", "Some examples of the storage devices are digital or solid-state memories, magnetic storage media such as a magnetic disks and magnetic tapes, hard drives, or optically readable digital data storage media.", "In one embodiment, the invention is implemented in software, which includes but is not limited to firmware, resident software, microcode, etc.", "FIG.", "16 illustrates a computing system 1600 in which a computer readable medium 1606 may provide instructions for performing any of the methods disclosed herein.", "Furthermore, the invention can take the form of a computer program product accessible from the computer readable medium 1606 providing program code for use by or in connection with a computer or any instruction execution system.", "For the purposes of this description, the computer readable medium 1606 can be any apparatus that can tangibly store the program for use by or in connection with the instruction execution system, apparatus, or device, including the computer system 1600.The medium 1606 can be any tangible electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system (or apparatus or device).", "Examples of a computer readable medium 1606 include a semiconductor or solid state memory, magnetic tape, a removable computer diskette, a random access memory (RAM), a read-only memory (ROM), a rigid magnetic disk and an optical disk.", "Some examples of optical disks include compact disk-read only memory (CD-ROM), compact disk-read/write (CD-R/W) and DVD.", "The computing system 1600, suitable for storing and/or executing program code, can include one or more processors 1602 coupled directly or indirectly to memory 1608 through a system bus 1610.The memory 1608 can include local memory employed during actual execution of the program code, bulk storage, and cache memories which provide temporary storage of at least some program code in order to reduce the number of times code is retrieved from bulk storage during execution.", "Input/output or I/O devices 1604 (including but not limited to keyboards, displays, pointing devices, etc.)", "can be coupled to the system either directly or through intervening I/O controllers.", "Network adapters may also be coupled to the system to enable the computing system 1600 to become coupled to other data processing systems, such as through host systems interfaces 1612, or remote printers or storage devices through intervening private or public networks.", "Modems, cable modem and Ethernet cards are just a few of the currently available types of network adapters.", "FIG.", "17 is a diagram 1700 illustratively representing a cable 1704 within a cable plant that has damage to the cable's shield, which causes it to act as a stationary leakage antenna 1710.Such damage is common in cable plants and may be caused by, for example, corrosion, stress fractures, animal chews, technician error, and construction vehicle error.", "The cable 1704 transports a leakage test signal 1702, and example of which is a stable continuous wave (CW) carrier or other deterministic signal, such as a DOCSIS 3.1 signal with pilots.", "The leakage test signal radiates to a mobile test antenna 1706 which is connected to a complex demodulator mobile receiver 1708, at a first antenna location 1716.The complex demodulator 1708 produces an in-phase (I) and quadrature (Q) signal sample for each of ‘N’ incremental steps 1711 over a synthetic phased array (SPA) distance 1712 as the receive antenna 1706 moves.", "In one example, incremental steps 1711 are separated by 15 cm and the number of incremental steps ‘N’ is an integer value such as 8 (as shown in FIG.", "17) or 128, or may be, for example, 2 raised to some integer exponent.", "The samples are each processed by a well-known discrete inverse Fourier transform, the output of which is a set of Doppler frequencies.", "In one embodiment, the mobile receive antenna 1706 were moving directly towards a leakage antenna 1710 at a velocity of 40 meter/sec and the CW test signal frequency is 900 MHz.", "The test signal's wavelength is readily computed as 3E8 meters per second (speed of light) divided by 900E6 Hz=0.333 meters.", "The Doppler frequency can then be computed as 40/0.333 or 120 Hz.", "However, if the Doppler frequency is a lower value, such as 80 Hz (at the 40 meter/sec antenna velocity), the mobile receive antenna 1706 is not moving directly towards the leakage antenna 1710, but moving at an angle to the leakage antenna 1710.A bearing angle 1714 (or bearing angle 1720) may be calculated as Acos(80/120)=48.19 degrees.", "Test antenna 1706 them moves to a second antenna location 1718 separated by a distance 1722 at which point second set of I-Q samples is generated.", "The second set of I-Q samples is then processed by a Fourier transform and, as described above for the first set of I-Q samples, a second bearing angle 1720 is produced using known methods.", "The intersection point of bearing angle 1714 from antenna location 1716 and bearing angle 1720 from antenna location 1722 shows the location of the leakage antenna 1710.In practice, many bearing angles can be computed from many antenna locations, increasing the accuracy of the determination of the location of leakage source 1710 by averaging.", "Likewise a larger value of ‘N’ produces improved bearing angle resolution.", "In one embodiment, mobile receiver 1708 is a software defined radio (SDR) such as Ettus Model B210 connected to a computing device, such as a portable computer, Raspberry Pi, O-Droid computing device, or similar device.", "In an embodiment, mobile receive antenna 1706 is an L-com monopole with omnidirectional antenna pattern, or similar.", "To achieve the necessary stability of both the leakage test signal 1702 and mobile receiver 1708 a Rubidium test standard may be employed.", "For example a Frequency Electronics Model 5680A may be used in both stationary and mobile locations.", "Alternately a GPS (global positioning system) disciplined oscillator, such as offered by Trimble Navigation, may be employed for the stable frequency references.", "One complication can occur when mobile receive antenna 1706 travels in a straight line such that ambiguity is created regrading which side of the road a leakage signal is on, that is, the intersections of bearing angles 1714, 1720 produced by the Acos function create a real location and a false location of leakage signal 1710.The bearing angle is actually half of the apex angle of a solid three dimensional cone, where the apex of the cone is antenna location 1716 or antenna location 1718.A three dimensional cone will intersect the ground along two lines, and the false line needs to be eliminated.", "If the path of the test antenna wavers, such as when a vehicle carrying the equipment turns or changes lanes, the intersection points will converge in the correct direction and diverge in the false direction.", "In another embodiment (similar to that shown in the transmit embodiment of FIG.", "18), a second mobile receive antenna (not shown but similar to the second mobile receive antenna 1806B in FIG.", "18) is locate proximate to the first mobile receive antenna 1706 and connected to another second mobile receiver.", "The mobile receive antenna may be placed alongside mobile receive antenna 1706 at, for example, a separation distance of 1-1.5 meters.", "The relative phase shifts between the mobile receivers 1708 and the second mobile receiver reveals the direction of a leakage source.", "That is, the leakage source will be on the side that experiences a higher Doppler frequency as the leakage antenna 1710 is passed.", "In another embodiment, two antennas are connected to a switch, such as an electronic double pole switch, that multiplexes or alternatively connects the two antennas to a single receiver, such that only a single receive is required thereby reducing cost of implementation.", "In a single receiver embodiment, a computer that receives data from the SDR (discussed above) may control the switch between the two antennas.", "By either adding additional antenna feed cable to one antenna or modifying antennas positions such that one is slightly forward of the other, the measurement points can be made at the same horizontal location as shown in FIG.", "17.This could be done for cost reduction, power reduction, or weight reduction such as may be beneficial in an airborne, terrestrial, or cable “walking” drone implementation.", "Usable with a GPS configured system, although not illustrated, is a GPS data logger receiver for recording antenna position as measurements are made such that data point may be geographically located.", "One example of such a PGS data logger received is a Columbus model V-800.From the GPS data the latitude, longitude values of leakage antennas, such as leakage antenna 1710 is located and recorded.", "It is also useful to record the strength of the leakage signal as well as the drive path that the mobile receive antenna 1706 took, date, and time.", "It should be noted that the use of a CW carrier test signal with a SPA provides for extreme sensitivity due to the narrow receiver noise bandwidth, and the processing gain and directional properties of the SPA.", "The embodiment described in FIG.", "17 may be utilized in multiple ways.", "It can be carried by a human or placed on a cart, where an accelerometer may cooperate with the system to provide uniform I-Q samples.", "The present system and method may also be mounted on a vehicle, examples of which include by are not limited to a cable service vehicle, a taxi, or a delivery vehicle.", "Likewise the embodiment can be flown by a manned aircraft or drone.", "When aerial, geometry considerations vary relative to ground testing.", "For example, when driving the 3-D cone intersects with the ground along a “V” shape.", "However, when flying the ground (containing the leakage antenna) intersects slices the 3-D cone along a hyperbola, assuming level flight.", "So geometric leakage calculations are made in three dimensions or four dimensions when time is included.", "Testing can be automatic, where a driver of a vehicle is not aware test data is being gathered.", "In this mode the collected leakage data can be uploaded over a wireless link, for example, when the vehicle is parked near a wireless data receiving unit.", "The data obtained by leakage detection can be manually or automatically placed into a data base and processed.", "By way of example, processing may focus on proactive network maintenance, troubleshooting interference with wireless services, or tracking new leaks or leaks that vary with time and weather.", "Research has indicated that cable leakage severity depends on a frequency of a test signal.", "Thus it is valuable to test at different frequencies.", "This can be done by changing the frequency of the test signal periodically.", "The antenna 1706 can be changed out for a new frequency antenna or a multiband antenna can be used.", "Alternately, an antenna may be used at a non-specified frequency and a correction factor can be applied to the recorded data.", "FIG.", "18 shows environment 1800 with the antenna system similar to that of FIG.", "17 configured on a truck.", "The antenna reciprocity theorem states that the transmit and receive properties of associated antennas are identical.", "Hence, it is also possible to transmit from one or more moving antennas and receive at the leakage antenna.", "In the embodiment of FIG.", "18, a mobile transmit antenna 1806 is mounted on a vehicle 1814, traveling down a road 1822, and emitting a test signal 1802.The test signal 1802 is received by a receive leakage antenna 1810 created by a shield break 1824.Test signal 1802, which may be a CW carrier, is generated by a moving test signal transmitter 1818.The received test signal is received at leakage antenna 1820 and propagates through cable line 1804 to a stationary receiver 1826.The stationary receiver 1826 may be at a fiber node, a hub site, a headend, in a home, or placed in the system for the present testing procedure.", "As mobile test antenna 1806 drives past leakage antenna 1810 Doppler shift information is collected at stationary receiver 1826, similar to the moving receiver embodiment, discussed above.", "One complexity in the transmit system is determining the exact travel path and timing of the mobile transmit antenna 1806 relative to the reception of the leakage test signal by the stationary receiver 1826.A position transmitting antenna 1812 may optionally be configured with vehicle 1814 such that it travels with moving transmit antennas 1806, 1806B.", "Antenna 1812 functions to send a position carrier 1816 with the latitude, longitude, and velocity of the vehicle 1814 to a position receiver, not shown.", "In another embodiment leakage antenna 1810 also receives the position carrier 1816.If nearby frequency band to the test signal's frequency is utilized for the position carrier 1816, a common single antenna may be used for both test signal 1802 and position carrier 1816 by combining the transmitted signals before connecting them to the common single antenna.", "Note that the present transmit system, which utilizes a single test signal 1802 from a single mobile transmit antenna 1806, has a similar left-right ambiguity problem as the embodiment discussed in FIG.", "17.This problem can be similarly resolved by locating a second mobile transmit antenna 1806B on vehicle 1814 proximate to antenna 1806.Test signal 1802 can be switched between transmitting antennas 206 and 206B rapidly by switch 220.The stationary receiver would synchronously switch output streams, recovering interleaved I-Q samples from both antennas at different times.", "FIG.", "19 is plot diagram 1900 that illustrates two Doppler shift vs. distance plots.", "It will be understood that the distance axis of plot diagram 1900 may be adapted to time if velocity is uniform over a given span.", "FIG.", "19 is discussed in relationship to FIG.", "18 and should be read as such.", "A first plot 1902 is produced from mobile transmitting antenna 1806 when it is at a first closer distance from shield break 1824.A second plot 1904 is produced from mobile transmitting antenna 1806B when it is at a second farther distance from shield break 1824.In an embodiment, a switch may be utilized to change between transmit antennas 1806, 1806B every 15 cm such that the SPA distances for each antenna 112 overlap.", "The antenna closer to leakage antenna 1810 (antenna 1806 in FIG.", "18) has an increased Doppler frequency change relative to the antenna farther away (antenna 1806B in FIG.", "18) due to faster rotation of phase.", "This feature makes it possible to eliminate the false leak image.", "Note that when the antenna's bearing angles are 90 degrees the plots will cross.", "In an embodiment, the present system and method may provide additional information to stationary receiver 1826 to instruct it as to which antenna's signal is currently being received.", "For example antenna 1806 may be configured to transmit slightly longer than antenna 1806B by varying the duty cycle of switch 212 from 50-50 to 55-45.The distance point of plot 1900 where the Doppler frequency goes through zero (hereinafter, zero point 1906) represents where the shield break is at right angles to the travel path of the antennas 1806, 1806B.", "Note that when the leakage antenna is far away from the antenna, the Doppler frequency approaches +F 1908 or −F 1910, which can be calculated from the wavelength and antenna velocity.", "Note that test signals travel at almost the speed of light, but the antenna velocity is much, much lower.", "The antenna velocity is used for Doppler frequency calculations.", "If a test antenna is driving at 40 meters per second, and the antenna acquires I-Q data point every 15 cm then the capture rate is one sample every 3.75 ms.", "Assuming a leak antenna, such as leakage antenna 1810, is 100 meters away from the mobile antenna, such as antenna 1806, 1806B, then the signal transit time between then is approximately 0.000333 ms, which can be considered virtually instantaneous.", "If it is desired to have a constant distance between synthetic phased array elements, such as 15 cm, sampling rates can be sped up as antenna velocity increases.", "Testing can even be done semi-statically if desired.", "That is, an I-Q measurement is made, the antenna is moved 15 cm and another I-Q measurement is made, which continues until enough samples are captured to perform a Fourier transform and make a SPA.", "FIG.", "20 is a diagram 2000 that illustrates a hand holdable antenna 2004 with one or more accelerometers 2006 in a base 2007, and a receiver/computing/display device 2008.The embodiment of FIG.", "20 is primarily intended for indoor leakage antenna location, as may be utilized inside a home or apartment building, although it also functional outdoors.", "As a technician (not shown) moves antenna 2004, received signal values are sent to receiver 2008 and accelerometer voltage samples, from accelerometer(s) 2006 are simultaneously sent to receiver 2008 over cable 2010.The three X, Y, and Z axes 2012 of antenna 2004 are located by computation elements within receiver 2008 utilizing the accelerometer data and received data.", "As the technician traces a circle with the antenna horizontally in an X-Z plane, the I-Q field strength values are recorded, along with the position of the antenna.", "This process may be repeated in the X-Y plane and in the Y-Z planes, forming a three dimensional (3-D) field strength map.", "From the field strength map the direction to the leakage antenna(s) may be determined.", "Indoor locations are frequently more difficult to analyze than outdoor applications because the leakage signal suffers multipath distortion, as well as diffraction.", "Another motion pattern that the technician can use for antenna 2004 is a straight line in each of the X, Y, and Z axes.", "Processing can be done as discussed in the parent (allowed) application.", "Yet another motion pattern that the technician can use is a zig-zag pattern where a two dimensional plane of (relatively) evenly-spaced samples are captured.", "Samples are captured while antenna is moved left-to-right while holding the forward position steady.", "Next, the antenna is advanced and moved right-to-left to get another set of samples.", "This is repeated until a test area is covered.", "This set of samples may be transformed with a 2-dimension IFFT to reveal the direction to a leakage signal.", "Likewise this technique can be used in 3-dimensions.", "While a computer-controlled actuator can give more accurate sample spacing relative to a human moving the antenna, the errors produced by a human moving the antenna can be reduced by interpolation.", "The hardware and software utilized in the embodiment of FIG.", "20 are similar to that described above for the many other embodiments.", "Changes may be made in the above methods and systems without departing from the scope hereof.", "It should thus be noted that the matter contained in the above description or shown in the accompanying drawings should be interpreted as illustrative and not in a limiting sense.", "The following claims are intended to cover all generic and specific features described herein, as well as all statements of the scope of the present method and system, which, as a matter of language, might be said to fall there between." ] ]
Patent_15872623
[ [ "Noise distribution shaping for signals, particularly spread spectrum signals like CDMA signals, with improved robustness", "Noise distribution shaping for signals, particularly for the application in receivers for CDMA signals.", "An embodiment provides a method for noise distribution shaping for signals comprising the acts of generating a blanking control signal by comparing a received signal comprising transitions with at least one blanking threshold, determining transitions of the received signal and zones around the determined transitions, and generating a transitions control signal comprising the determined transitions and zones, adapting the at least one blanking threshold or the received signal according to an offset value depending on the amplitude of the received signal and on the transitions control signal, and modifying the noise distribution of the received signal by applying blanking of the received signal under control of the blanking control signal." ], [ "1.A method for noise distribution shaping for signals comprising the acts of generating a blanking control signal by comparing a received signal comprising transitions with at least one blanking threshold, determining transitions of the received signal and zones around the determined transitions, and generating a transitions control signal comprising the determined transitions and zones, adapting the at least one blanking threshold or the received signal according to an offset value depending on the amplitude of the received signal and on the transitions control signal, and modifying the noise distribution of the received signal by applying blanking of the received signal under control of the blanking control signal.", "2.The method of claim 1, wherein the transitions are determined by at least one tracking loop for tracking the received signal.", "3.The method of claim 1, wherein the durations of the zones around the determined transitions are set to a constant value.", "4.The method of claim 3, wherein the constant value is selected depending on the accuracy of a tracking loop for tracking the received signal.", "5.The method of claim 1, wherein the durations of the zones around the determined transitions are adapted during the entire process of the noise distribution shaping.", "6.The method of claim 1, wherein the generating of the blanking control signal comprises setting the at least one blanking threshold within the zones around the determined transitions to a predefined value, which is selected such that the adapting of the at least one blanking threshold is interrupted within the zones, or interrupting the adapting of the received signal within the zones around the determined transitions.", "7.The method of claim 1, wherein transitions of the received signal and zones around the determined transitions are only determined for consecutive signal states of different polarity.", "8.A device for noise distribution shaping for signals comprising means for generating a blanking control signal by comparing a received signal comprising transitions with at least one blanking threshold, means for generating a transitions control signal depending on determined transitions of the received signal and zones around the determined transitions, means for adapting the at least one blanking threshold or the received signal according to an offset value depending on the amplitude of the received signal and on the transitions control signal, and means for modifying the noise distribution of the received signal by applying blanking of the received signal under control of the blanking control signal.", "9.The device of claim 8, wherein the means for generating a transitions control signal are configured to set the durations of the zones around the determined transitions to a constant value.", "10.The device of claim 9, wherein the means for generating a transitions control signal are configured to select the constant value of the zones durations depending on the accuracy of a tracking loop for tracking the received signal.", "11.The device of claim 8, wherein the means for generating a transitions control signal are configured to adapt the durations of the zones around the determined transitions during noise distribution shaping.", "12.The device of claim 8, wherein the means for generating a blanking control signal are configured to set the at least one blanking threshold within the zones around the determined transitions to a predefined value, which is selected such that the adapting of the at least one blanking threshold is interrupted within the zones, or to interrupt the adapting of the received signal within the zones around determined transitions.", "13.The device of claim 8, wherein the means for generating a transitions control signal are configured to only determine transitions of the received signal and zones around the determined transitions for consecutive signal states of different polarity.", "14.The device of claim 8, wherein the received signal is a CDMA signal, specifically a BSPK or BOC modulated binary signal, and the means for adapting are configured to calculate the offset value by multiplying the square root of the estimated power Pest with a scaling factor being +1 or −1 depending on the chip values of the CDMA signal.", "15.A GNSS receiver circuitry comprising an analog to digital converter for generating samples of received CDMA signals, a plurality of noise distribution shapers for modifying the noise distribution of the sampled CDMA signals according to claim 8, and a GNSS signal processor for processing the sampled CDMA signals output by the noise distribution shapers and for outputting chip values of the processed CDMA signals." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Interferences on radio signals such as CDMA (Code Division Multiple Access) signals emitted by satellites of a GNSS (Global Navigation Satellite System) particularly occur in impulse noise environments such as in the neighborhood of vehicle ignition systems, power lines, heavy current switches or microwave ovens.", "The interferences occurring in these environments are usually emitted in bursts and, thus, cannot be modelled as Gaussian.", "In order to reduce the effects of pulsed interferences on the reception of a radio signal, a (noise) blanker can be applied in a signal receiver.", "The blanker sets received signal samples to zero when they contain high power pulsed interferences.", "The typical blanker uses two fixed thresholds BTH+and BTH−, which are symmetrical to zero (|BTH+|=|BTH−|).", "If a received signal sample contains interferences and exceeds a threshold, the sample is set to zero by the blanker.", "Typical receivers for CDMA signals are equipped with such a blanker.", "In the absence of interference, which may be for some signals receivers a frequent situation, the blanker still operates and sets the portions of a received signal to zero, which are affected by large thermal noise samples (usually modelled as Gaussian).", "However, this may lead to an undesired reduction of the Signal-to-Noise and Interference Ratio (SNIR).", "U.S. Pat.", "No.", "7,260,163 B2 describes a noise blanker for application with a FM signal receiver of a radio as installed in a vehicle.", "In order to reduce the effect of ignition noise on a received FM signal, a noise controller is provided, which uses an all-pole prediction algorithm to replace a noise-corrupted signal segment.", "The all-pole prediction algorithm takes a sample of a previously demodulated signal and models a new demodulated signal segment using the all-pole prediction algorithm The algorithm uses a least means squared (LMS) algorithm to minimize error between the received original signal and the predicted signal.", "European patent application no.", "14290171.9, which is incorporated herein by reference and is considered as comprised in the state of the art according to Article 54(3) of the European Patent Convention, describes to offset either blanking thresholds or a received signal by an offset value.", "The main advantage of this blanking approach is seen in the suppression of the degradation of the SNIR of a received CDMA signal when there are no pulsed interferences and even an improvement of the SNIR.", "This blanking concept is also described in the publication “GNSS Receiver Performance Augmentation With a Smart Adaptive Noise Blanker in Pulse-Free Environment,” Mathieu Cattenoz, Francis Soualle, “7th ESA Workshop on Satellite Navigation Technologies (NAVITEC),” 3-5 Dec. 2014 at the European Space Research and Technology Centre (ESTEC) in Noordwijk, The Netherlands." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>It is an object of the present invention to further develop the blanking approach described in the European patent application no.", "14290171.9, particularly to improve its application in multipath environments or with high dynamic or with high noisy environment.", "In the above referenced European patent application no.", "14290171.9, it is proposed to offset the positive and negative blanking thresholds with respect to the sign and amplitude of the tracked chips of a received signal, particularly a CDMA signal of for example a GNSS.", "Particularly, it is proposed to apply a positive (resp.", "negative) offset during the full duration of the positive (resp.", "negative) “chip.” This may improve the SNIR provided that the delay of the received signal is nearly perfectly synchronized.", "The present invention is based on the finding that the blanking thresholds are synchronized to a received signal chip stream (whose amplitude is typically smaller than the standard deviation of the noise) only in an ideal situation, and that in reality a receiver of the signal does not know precisely when the exact chip transition occurs, but can only estimate it with tracking loops.", "A chip transition is the transition between two consecutive chips regardless of the polarity of the consecutive chips.", "As a consequence, in a real scenario the exact position of the chip transition will be known with the accuracy of the tracking loops.", "Such loops will consequently help triggering the positive or negative offset of both thresholds.", "Thus, the present invention proposes to determine zones or regions around chip transitions, where the use of a dedicated offset is applied differently than in the zones out-of-the chip transitions.", "For example, it may be provided that in the determined zones, no offset is applied so that the zones are a kind of “dead zones” where the nominal blanking thresholds are not offset.", "The size of a zone or region without offset could depend on the dynamic foreseen for the application type (which typically may differ for pedestrian or airborne users, for the example of a GNSS) but also the tracking accuracy.", "By introducing such zones around chip transitions, the invention based on the blanking approach described in the European patent application no.", "14290171.9 becomes more robust in case of synchronization errors caused by noise, dynamic or multipath.", "The present invention is based on the blanking approach described in the European patent application no.", "14290171.9, which comprises offsetting either blanking thresholds or a received signal by an offset value.", "In particular, this offset value can depend on the amplitude of the received signal.", "For example, the amplitude of the received signal can be calculated based on the estimated power, Pest, of the received signal and its sign.", "Herein it is generally assumed that the amplitude of the signal can have a positive or a negative value.", "The offset value can be for example calculated by multiplying the square root of the estimated power with a predefined scaling factor α which can be positive or negative: α×sqrt(Pest).", "It has been found by the inventors that in case of CDMA signals, a scaling factor +1 or −1—so that the offset value is ±sqrt(Pest).—depending on the chip value, has advantageous effects.", "This invention may be advantageously applied to signals with dominant noise content, such as CDMA coded signals, for example GNSS signals.", "The invention can be applied to signals before or after down-conversion into a baseband, for example after down-conversion and analog-to-digital conversion or directly after an analog-to-digital conversion before a down-conversion into a baseband.", "The invention can be applied to any kind of signal containing a significant proportion of noise.", "Generally, an offsetting can be performed with the signal amplitude.", "In the special case of a CDMA signal, this offsetting can correspond to the chip amplitude±sqrt(Pest) with a scaling factor α=±1.The most important aspect is that the noise is dominant, i.e., has much larger power than the received signal power P, and therefore to its estimate Pest.", "In case of received CDMA signals, at least one blanking threshold may be adapted depending on the estimated received power and the binary chip value of the received CDMA signals.", "The binary chip value of a CDMA signal is known by a CDMA signal receiver a priori since the spreading sequence used to code the CDMA signal is constituted of a sequence of chips, which has to be known by a receiver for decoding and despreading the CDMA signal.", "In the following, and in the particular case of a CDMA signal, the estimated chip amplitude is ±sqrt(Pest) while the binary chip value is ±1.The adaption of the at least one blanking threshold depending on the binary chip values of received CDMA signals modifies the noise distribution of the output of a blanker of a CDMA signal receiver.", "Instead of adapting blanking thresholds, the samples of the CDMA signals may be adapted, for example offset; then, the adapted CDMA samples may be compared with fixed blanking thresholds, and the noise distribution of the sampled CDMA signals may be modified by applying blanking An offsetting of the samples of CDMA signals may be performed by a value depending on the estimated chip amplitude of the CDMA signals.", "For example, the binary chip value scaled by the estimated amplitude of a received CDMA signal may be added or subtracted from samples of the received CDMA signal.", "Those samples are then fed to the blanker with non-offset thresholds.", "After the blanking operation, the offsetting of the samples of the CDMA signal can be removed.", "Analytical and simulation work conducted for this invention has shown that this modification cannot only reduce the SNIR degradations caused by the blanking, but can even improve the SNIR by an optimized shaping of the noise distribution of a received CDMA signal.", "Generally speaking, the invention extends from the concept of two blanking thresholds BTH+, BTH− with opposite values, as described above, to a set of N blanking thresholds BTH{i,k,n} which “cuts” regions of the distribution of samples of a received signal, and particularly a CDMA signal, at the input of a blanker to improve again the SNIR.", "Here, i is the index of the channel processing the ith signal source among I sources, k is a time index and n is a threshold index, among N thresholds.", "Indeed, in case of CDMA signals, for each tracked CDMA signal a different chip sequence also called replica is used and therefore a different threshold should be applied to each time instant.", "The different blanking thresholds BTH{i,k,n} do not have to be pairwise symmetrical with respect to zero for each signal i and time instant k, and their value can depend, for example in case of CDMA signal on the chip amplitude.", "For example, a set of scaling factors α{i,k,n}, which are functions of the received signal, time and threshold index, can be multiplied with the estimated power of the ith signal, so that the blanking thresholds, BTH{i,k,n} are offset of pre-defined blanking thresholds values with α{i,k,n}×sqrt(Pest,i,k) as offset.", "In this former equation Pest depends on the received signal i and also of the time instant k. Alternatively, it is also possible to consider a set of offset values applied to the received signal while keeping the blanking thresholds fixed.", "The set of offset values could depend on the signal i being tracked and on the time k. In that alternative implementation, the signal amplitude is offset by an offset value, while the blanking thresholds are kept fixed.", "The offset signal is fed to the blanker with non-offset thresholds.", "After blanking operation, the offset applied to the blanked signal can be removed.", "The main advantage of the invention is the reduction of the degradation of the SNIR of a received CDMA signal when there are no pulsed interferences, and even an improvement of the robustness in case of synchronization errors caused for example by noise, dynamic or multipath.", "It should be noted that the present invention can be applied to any kind of signals, particularly spread spectrum coded signal such as CDMA signals, particularly to BPSK (Binary Phase Shift Keying)- and BOC (Binary Offset Carrier)-modulated CDMA signals used by GNSS such as (NAVSTAR-) GPS (Global Positioning System) or the European GNSS Galileo.", "For BOC signals each chip with a single “plateau” (in case of for example a BPSK-modulated signal) is replaced by several smaller plateaus [+1, −1].", "The present invention, which is presented for the transition of a for example BPSK-modulated signal single plateau, would apply to the transitions of the sub-plateaus of a BOC-modulated signal, or any other signal comprising transitions, like for example chirp radar signals, or continuous wave signals.", "In case of spread spectrum coded signals, the signal transitions are transitions between consecutive chips of a sequence of chips used for coding the signal.", "In the context of the present invention, a signal transition is generally understood as a transition between signal states in a time frame, like the transitions between bits, chips or the like of a sequence of bits or chips.", "Thus, signal transition can also occur between two consecutive signal states, particularly bits or chips, of the same polarity, not even of different polarity.", "An embodiment of the present invention relates to a method for noise distribution shaping for signals comprising the acts of generating a blanking control signal by comparing a received signal comprising a sequence of with at least one blanking threshold, determining transitions of the received signal and zones around the determined transitions, and generating a transitions control signal comprising the determined transitions and zones, adapting the at least one blanking threshold or the received signal according to an offset value depending on the amplitude of the received signal and on the transitions control signal, and modifying the noise distribution of the received signal by applying blanking of the received signal under control of the blanking control signal.", "The transitions may be determined by at least one tracking loop for tracking the received signal, for example a DLL (Delay Locked Loop) and/or a PLL (Phase Locked Loop).", "The durations of the zones around the determined transitions may be set to a constant value.", "This means that the time between the start and the end of the zones is constant.", "For example, the constant value may be defined depending on the a priori accuracy of a tracking loop for tracking the received signal.", "Particularly, the constant value may be defined so to over bound the maximum expected error of a tracking loop, which is determined by the tracking accuracy.", "Alternatively, the durations of the zones around the determined transitions may be adapted during noise distribution shaping.", "This means that the zones durations may be variable and adapted to the accuracy of a tracking loop, preferably in real-time.", "The generating of the blanking control signal may comprise setting the at least one blanking threshold within the zones around the determined transitions to a predefined value, which is selected such that the adapting of the at least one blanking threshold is interrupted within the zones.", "In other words, the adaptation of the blanking thresholds is “paused” within the zones, particularly the at least one blanking threshold is not offset within the zones.", "Alternatively, the generating of the blanking control signal may comprise interrupting the adapting of the received signal (samples) within the zones around the determined transitions so that the samples of the received signal are not offset within the zones, and are still fed to the at least one blanking threshold having a predefined value.", "Here, the adaptation of the received spread spectrum signal “samples” is “paused” within the zones.", "Alternatively to determining transitions of the received signal for every signal state regardless of the polarities, it is possible to determine transitions of the received signal and zones around the determined transitions only for consecutive signal states of different polarity.", "Thus, for consecutive signal states (chips in case of a spread spectrum coded signal) of the same polarity no zone would be determined and, consequently, the adaptation of the at least one blanking threshold would have not to be “paused” or interrupted during a transition between such signal states.", "In other words, the adaptation of the at least blanking threshold would only be paused or interrupted during transitions between consecutive signal states of different polarity.", "The amplitude of the received signal can be calculated based on the estimated power Pest of the received signal and the offset value can be calculated from the calculated amplitude of the received signal, particularly by multiplying the square root of the estimated power Pest with a predefined scaling factor α.", "Particularly, the predefined scaling factor α can be positive or negative, constant or time dependent, or the sign of the predefined scaling factor α can change over time as function of the received signal.", "The act of adapting of the at least one blanking threshold or adapting the received signal, respectively, according to an offset value depending on the amplitude of the received signal may comprise offsetting at least one predefined blanking threshold or the received signal, respectively, with the scaled estimated amplitude of the received signal.", "For example, the amplitude scaled by a coefficient, may be added or subtracted from the at least one blanking threshold without modifying the received signal or may be added or subtracted from the amplitude of the received signal without modifying the blanking threshold.", "The act of modifying the noise distribution of the received signal by applying blanking under control of the blanking control signal may comprise setting a sample of the received signal to a predefined value depending on the blanking control signal.", "Particularly, samples of the received signal, which exceed the blanking thresholds, may be set to 0.A set of blanking thresholds may be used, wherein the set comprises at least one blanking threshold for each one of a plurality of received signals.", "This allows using different blanking thresholds for different received signals.", "The received signal may be a CDMA signal, and the offset value may be calculated by multiplying the square root of the estimated power Pest with a scaling factor being +1 or −1 depending on the chip values of the CDMA signal.", "The adapting of the received signal depending on the amplitude of the received signal may be performed in the digital domain after an analog to digital conversion of the samples of the received signal.", "A further embodiment of the invention relates to a computer program, which implements the method for noise distribution shaping for signals according to the invention and as described herein and enabling noise distribution shaping for signals according to the invention when executed by a computer.", "Such a computer program could be used by a computer equipped with a receiver comprising an antenna for receiving different signals, for example CDMA signals from satellites of a GNSS, enabling the computer to improve the SNIR of the received signals by applying the inventive noise blanking method.", "According to a further embodiment of the invention, a record carrier storing a computer program according to the invention may be provided, for example a CD-ROM, a DVD, a memory card, a diskette, or a similar data carrier suitable to store the computer program for electronic access.", "A yet further embodiment of the invention relates to device for noise distribution shaping for signals comprising means for generating a blanking control signal by comparing a received signal comprising transitions with at least one blanking threshold, means for generating a transitions control signal depending on determined transitions of the received signal and zones around the determined transitions, means for adapting the at least one blanking threshold or the received signal according to an offset value depending on the amplitude of the received signal and on the transitions control signal, and means for modifying the noise distribution of the received signal by applying blanking of the received signal under control of the blanking control signal.", "The means for generating transitions control signal may be configured to set the durations of zones around the determined transitions to a constant value.", "The means for generating a transitions control signal may be configured to select the constant value of the zones durations depending on the accuracy of a tracking loop for tracking the received signal.", "Alternatively, the means for generating transitions control signal may be configured to adapt the durations of the zones around the determined transitions during noise distribution shaping.", "The means for generating a blanking control signal may be configured to set the at least one blanking threshold within the zones around the determined transitions to a predefined value, which is selected such that the adapting of the at least one blanking threshold is interrupted within the zones.", "In other words, the adaptation of the blanking thresholds is “paused” within the zones, or the at least one blanking threshold is not offset within the zones.", "Alternatively, means for generating a blanking control signal may be configured to interrupt the adapting of the received signal (samples) within the zones around the determined transitions so that the samples of the received signal are not offset within the zones, and are still fed to the at least one blanking threshold having a predefined value.", "Here, the means for generating a blanking control signal “pause” the adaptation of the received spread spectrum signal within the zones.", "The means for adapting may be further configured to calculate the amplitude of the received signal based on the estimated received power Pest of the received signal and to calculate the offset value from the calculated amplitude of the received signal, particularly by multiplying the square root of the estimated power Pest with a predefined scaling factor α.", "Particularly, the predefined scaling factor α can be positive or negative, constant or time dependent, or the sign of the predefined scaling factor α can change over time as function of the received signal.", "The means for generating a blanking control signal may comprise a comparator circuit with a first input for receiving signal samples and at least one second input for receiving the at least one blanking threshold.", "The means for adapting the at least one blanking threshold or adapting the received signal, respectively, according to an offset value which depends on the amplitude of the received signal may comprise means for offsetting the at least one predefined blanking threshold or the received signal, respectively, with the scaled amplitude of the received signal.", "The means for modifying the noise distribution of the received signal by applying blanking of the received signal under control of the blanking control signal may comprise means for setting a sample of the received signal to a predefined value depending on the blanking control signal.", "Particularly, samples of the received signal, which exceed the blanking thresholds, may be set to 0.The device may be configured to use a set of blanking thresholds, wherein the set comprises at least one blanking threshold for each one of a plurality of received signals.", "The means for generating a transitions control signal may be configured to only determine transitions of the received signal and zones around the determined transitions for consecutive signal states of different polarity.", "The received signal may be a CDMA signal, and the means for adapting may be configured to calculate the offset value by multiplying the square root of the estimated power Pest with a scaling factor being +1 or −1 depending on the chip values of the CDMA signal.", "A yet further embodiment of the invention relates to a GNSS receiver circuitry comprising an analog to digital converter for generating samples of received CDMA signals, a plurality of noise distribution shapers for modifying the noise distribution of the sampled CDMA signals according to the invention and as described herein, and a GNSS signal processor for processing the sampled CDMA signals output by the noise distribution shapers and for outputting chip values of the processed CDMA signals.", "These and other aspects of the invention will be apparent from and elucidated with reference to the embodiments described hereinafter.", "The invention will be described in more detail hereinafter with reference to exemplary embodiments.", "However, the invention is not limited to these exemplary embodiments." ], [ "CROSS-REFERENCES TO RELATED APPLICATIONS This application is a continuation of International Application PCT/EP2016/066151 filed Jul.", "7, 2016, designating the United States and published on Jan. 26, 2017 as WO 2017/012887.This application also claims the benefit of the European patent application No.", "15002130.1 filed on Jul.", "17, 2015.The entire disclosures of the above are incorporated herein by way of reference.", "TECHNICAL FIELD The invention relates to noise distribution shaping for signals, particularly for the application in receivers for CDMA signals.", "BACKGROUND OF THE INVENTION Interferences on radio signals such as CDMA (Code Division Multiple Access) signals emitted by satellites of a GNSS (Global Navigation Satellite System) particularly occur in impulse noise environments such as in the neighborhood of vehicle ignition systems, power lines, heavy current switches or microwave ovens.", "The interferences occurring in these environments are usually emitted in bursts and, thus, cannot be modelled as Gaussian.", "In order to reduce the effects of pulsed interferences on the reception of a radio signal, a (noise) blanker can be applied in a signal receiver.", "The blanker sets received signal samples to zero when they contain high power pulsed interferences.", "The typical blanker uses two fixed thresholds BTH+and BTH−, which are symmetrical to zero (|BTH+|=|BTH−|).", "If a received signal sample contains interferences and exceeds a threshold, the sample is set to zero by the blanker.", "Typical receivers for CDMA signals are equipped with such a blanker.", "In the absence of interference, which may be for some signals receivers a frequent situation, the blanker still operates and sets the portions of a received signal to zero, which are affected by large thermal noise samples (usually modelled as Gaussian).", "However, this may lead to an undesired reduction of the Signal-to-Noise and Interference Ratio (SNIR).", "U.S. Pat.", "No.", "7,260,163 B2 describes a noise blanker for application with a FM signal receiver of a radio as installed in a vehicle.", "In order to reduce the effect of ignition noise on a received FM signal, a noise controller is provided, which uses an all-pole prediction algorithm to replace a noise-corrupted signal segment.", "The all-pole prediction algorithm takes a sample of a previously demodulated signal and models a new demodulated signal segment using the all-pole prediction algorithm The algorithm uses a least means squared (LMS) algorithm to minimize error between the received original signal and the predicted signal.", "European patent application no.", "14290171.9, which is incorporated herein by reference and is considered as comprised in the state of the art according to Article 54(3) of the European Patent Convention, describes to offset either blanking thresholds or a received signal by an offset value.", "The main advantage of this blanking approach is seen in the suppression of the degradation of the SNIR of a received CDMA signal when there are no pulsed interferences and even an improvement of the SNIR.", "This blanking concept is also described in the publication “GNSS Receiver Performance Augmentation With a Smart Adaptive Noise Blanker in Pulse-Free Environment,” Mathieu Cattenoz, Francis Soualle, “7th ESA Workshop on Satellite Navigation Technologies (NAVITEC),” 3-5 Dec. 2014 at the European Space Research and Technology Centre (ESTEC) in Noordwijk, The Netherlands.", "SUMMARY OF THE INVENTION It is an object of the present invention to further develop the blanking approach described in the European patent application no.", "14290171.9, particularly to improve its application in multipath environments or with high dynamic or with high noisy environment.", "In the above referenced European patent application no.", "14290171.9, it is proposed to offset the positive and negative blanking thresholds with respect to the sign and amplitude of the tracked chips of a received signal, particularly a CDMA signal of for example a GNSS.", "Particularly, it is proposed to apply a positive (resp.", "negative) offset during the full duration of the positive (resp.", "negative) “chip.” This may improve the SNIR provided that the delay of the received signal is nearly perfectly synchronized.", "The present invention is based on the finding that the blanking thresholds are synchronized to a received signal chip stream (whose amplitude is typically smaller than the standard deviation of the noise) only in an ideal situation, and that in reality a receiver of the signal does not know precisely when the exact chip transition occurs, but can only estimate it with tracking loops.", "A chip transition is the transition between two consecutive chips regardless of the polarity of the consecutive chips.", "As a consequence, in a real scenario the exact position of the chip transition will be known with the accuracy of the tracking loops.", "Such loops will consequently help triggering the positive or negative offset of both thresholds.", "Thus, the present invention proposes to determine zones or regions around chip transitions, where the use of a dedicated offset is applied differently than in the zones out-of-the chip transitions.", "For example, it may be provided that in the determined zones, no offset is applied so that the zones are a kind of “dead zones” where the nominal blanking thresholds are not offset.", "The size of a zone or region without offset could depend on the dynamic foreseen for the application type (which typically may differ for pedestrian or airborne users, for the example of a GNSS) but also the tracking accuracy.", "By introducing such zones around chip transitions, the invention based on the blanking approach described in the European patent application no.", "14290171.9 becomes more robust in case of synchronization errors caused by noise, dynamic or multipath.", "The present invention is based on the blanking approach described in the European patent application no.", "14290171.9, which comprises offsetting either blanking thresholds or a received signal by an offset value.", "In particular, this offset value can depend on the amplitude of the received signal.", "For example, the amplitude of the received signal can be calculated based on the estimated power, Pest, of the received signal and its sign.", "Herein it is generally assumed that the amplitude of the signal can have a positive or a negative value.", "The offset value can be for example calculated by multiplying the square root of the estimated power with a predefined scaling factor α which can be positive or negative: α×sqrt(Pest).", "It has been found by the inventors that in case of CDMA signals, a scaling factor +1 or −1—so that the offset value is ±sqrt(Pest).—depending on the chip value, has advantageous effects.", "This invention may be advantageously applied to signals with dominant noise content, such as CDMA coded signals, for example GNSS signals.", "The invention can be applied to signals before or after down-conversion into a baseband, for example after down-conversion and analog-to-digital conversion or directly after an analog-to-digital conversion before a down-conversion into a baseband.", "The invention can be applied to any kind of signal containing a significant proportion of noise.", "Generally, an offsetting can be performed with the signal amplitude.", "In the special case of a CDMA signal, this offsetting can correspond to the chip amplitude±sqrt(Pest) with a scaling factor α=±1.The most important aspect is that the noise is dominant, i.e., has much larger power than the received signal power P, and therefore to its estimate Pest.", "In case of received CDMA signals, at least one blanking threshold may be adapted depending on the estimated received power and the binary chip value of the received CDMA signals.", "The binary chip value of a CDMA signal is known by a CDMA signal receiver a priori since the spreading sequence used to code the CDMA signal is constituted of a sequence of chips, which has to be known by a receiver for decoding and despreading the CDMA signal.", "In the following, and in the particular case of a CDMA signal, the estimated chip amplitude is ±sqrt(Pest) while the binary chip value is ±1.The adaption of the at least one blanking threshold depending on the binary chip values of received CDMA signals modifies the noise distribution of the output of a blanker of a CDMA signal receiver.", "Instead of adapting blanking thresholds, the samples of the CDMA signals may be adapted, for example offset; then, the adapted CDMA samples may be compared with fixed blanking thresholds, and the noise distribution of the sampled CDMA signals may be modified by applying blanking An offsetting of the samples of CDMA signals may be performed by a value depending on the estimated chip amplitude of the CDMA signals.", "For example, the binary chip value scaled by the estimated amplitude of a received CDMA signal may be added or subtracted from samples of the received CDMA signal.", "Those samples are then fed to the blanker with non-offset thresholds.", "After the blanking operation, the offsetting of the samples of the CDMA signal can be removed.", "Analytical and simulation work conducted for this invention has shown that this modification cannot only reduce the SNIR degradations caused by the blanking, but can even improve the SNIR by an optimized shaping of the noise distribution of a received CDMA signal.", "Generally speaking, the invention extends from the concept of two blanking thresholds BTH+, BTH− with opposite values, as described above, to a set of N blanking thresholds BTH{i,k,n} which “cuts” regions of the distribution of samples of a received signal, and particularly a CDMA signal, at the input of a blanker to improve again the SNIR.", "Here, i is the index of the channel processing the ith signal source among I sources, k is a time index and n is a threshold index, among N thresholds.", "Indeed, in case of CDMA signals, for each tracked CDMA signal a different chip sequence also called replica is used and therefore a different threshold should be applied to each time instant.", "The different blanking thresholds BTH{i,k,n} do not have to be pairwise symmetrical with respect to zero for each signal i and time instant k, and their value can depend, for example in case of CDMA signal on the chip amplitude.", "For example, a set of scaling factors α{i,k,n}, which are functions of the received signal, time and threshold index, can be multiplied with the estimated power of the ith signal, so that the blanking thresholds, BTH{i,k,n} are offset of pre-defined blanking thresholds values with α{i,k,n}×sqrt(Pest,i,k) as offset.", "In this former equation Pest depends on the received signal i and also of the time instant k. Alternatively, it is also possible to consider a set of offset values applied to the received signal while keeping the blanking thresholds fixed.", "The set of offset values could depend on the signal i being tracked and on the time k. In that alternative implementation, the signal amplitude is offset by an offset value, while the blanking thresholds are kept fixed.", "The offset signal is fed to the blanker with non-offset thresholds.", "After blanking operation, the offset applied to the blanked signal can be removed.", "The main advantage of the invention is the reduction of the degradation of the SNIR of a received CDMA signal when there are no pulsed interferences, and even an improvement of the robustness in case of synchronization errors caused for example by noise, dynamic or multipath.", "It should be noted that the present invention can be applied to any kind of signals, particularly spread spectrum coded signal such as CDMA signals, particularly to BPSK (Binary Phase Shift Keying)- and BOC (Binary Offset Carrier)-modulated CDMA signals used by GNSS such as (NAVSTAR-) GPS (Global Positioning System) or the European GNSS Galileo.", "For BOC signals each chip with a single “plateau” (in case of for example a BPSK-modulated signal) is replaced by several smaller plateaus [+1, −1].", "The present invention, which is presented for the transition of a for example BPSK-modulated signal single plateau, would apply to the transitions of the sub-plateaus of a BOC-modulated signal, or any other signal comprising transitions, like for example chirp radar signals, or continuous wave signals.", "In case of spread spectrum coded signals, the signal transitions are transitions between consecutive chips of a sequence of chips used for coding the signal.", "In the context of the present invention, a signal transition is generally understood as a transition between signal states in a time frame, like the transitions between bits, chips or the like of a sequence of bits or chips.", "Thus, signal transition can also occur between two consecutive signal states, particularly bits or chips, of the same polarity, not even of different polarity.", "An embodiment of the present invention relates to a method for noise distribution shaping for signals comprising the acts of generating a blanking control signal by comparing a received signal comprising a sequence of with at least one blanking threshold, determining transitions of the received signal and zones around the determined transitions, and generating a transitions control signal comprising the determined transitions and zones, adapting the at least one blanking threshold or the received signal according to an offset value depending on the amplitude of the received signal and on the transitions control signal, and modifying the noise distribution of the received signal by applying blanking of the received signal under control of the blanking control signal.", "The transitions may be determined by at least one tracking loop for tracking the received signal, for example a DLL (Delay Locked Loop) and/or a PLL (Phase Locked Loop).", "The durations of the zones around the determined transitions may be set to a constant value.", "This means that the time between the start and the end of the zones is constant.", "For example, the constant value may be defined depending on the a priori accuracy of a tracking loop for tracking the received signal.", "Particularly, the constant value may be defined so to over bound the maximum expected error of a tracking loop, which is determined by the tracking accuracy.", "Alternatively, the durations of the zones around the determined transitions may be adapted during noise distribution shaping.", "This means that the zones durations may be variable and adapted to the accuracy of a tracking loop, preferably in real-time.", "The generating of the blanking control signal may comprise setting the at least one blanking threshold within the zones around the determined transitions to a predefined value, which is selected such that the adapting of the at least one blanking threshold is interrupted within the zones.", "In other words, the adaptation of the blanking thresholds is “paused” within the zones, particularly the at least one blanking threshold is not offset within the zones.", "Alternatively, the generating of the blanking control signal may comprise interrupting the adapting of the received signal (samples) within the zones around the determined transitions so that the samples of the received signal are not offset within the zones, and are still fed to the at least one blanking threshold having a predefined value.", "Here, the adaptation of the received spread spectrum signal “samples” is “paused” within the zones.", "Alternatively to determining transitions of the received signal for every signal state regardless of the polarities, it is possible to determine transitions of the received signal and zones around the determined transitions only for consecutive signal states of different polarity.", "Thus, for consecutive signal states (chips in case of a spread spectrum coded signal) of the same polarity no zone would be determined and, consequently, the adaptation of the at least one blanking threshold would have not to be “paused” or interrupted during a transition between such signal states.", "In other words, the adaptation of the at least blanking threshold would only be paused or interrupted during transitions between consecutive signal states of different polarity.", "The amplitude of the received signal can be calculated based on the estimated power Pest of the received signal and the offset value can be calculated from the calculated amplitude of the received signal, particularly by multiplying the square root of the estimated power Pest with a predefined scaling factor α.", "Particularly, the predefined scaling factor α can be positive or negative, constant or time dependent, or the sign of the predefined scaling factor α can change over time as function of the received signal.", "The act of adapting of the at least one blanking threshold or adapting the received signal, respectively, according to an offset value depending on the amplitude of the received signal may comprise offsetting at least one predefined blanking threshold or the received signal, respectively, with the scaled estimated amplitude of the received signal.", "For example, the amplitude scaled by a coefficient, may be added or subtracted from the at least one blanking threshold without modifying the received signal or may be added or subtracted from the amplitude of the received signal without modifying the blanking threshold.", "The act of modifying the noise distribution of the received signal by applying blanking under control of the blanking control signal may comprise setting a sample of the received signal to a predefined value depending on the blanking control signal.", "Particularly, samples of the received signal, which exceed the blanking thresholds, may be set to 0.A set of blanking thresholds may be used, wherein the set comprises at least one blanking threshold for each one of a plurality of received signals.", "This allows using different blanking thresholds for different received signals.", "The received signal may be a CDMA signal, and the offset value may be calculated by multiplying the square root of the estimated power Pest with a scaling factor being +1 or −1 depending on the chip values of the CDMA signal.", "The adapting of the received signal depending on the amplitude of the received signal may be performed in the digital domain after an analog to digital conversion of the samples of the received signal.", "A further embodiment of the invention relates to a computer program, which implements the method for noise distribution shaping for signals according to the invention and as described herein and enabling noise distribution shaping for signals according to the invention when executed by a computer.", "Such a computer program could be used by a computer equipped with a receiver comprising an antenna for receiving different signals, for example CDMA signals from satellites of a GNSS, enabling the computer to improve the SNIR of the received signals by applying the inventive noise blanking method.", "According to a further embodiment of the invention, a record carrier storing a computer program according to the invention may be provided, for example a CD-ROM, a DVD, a memory card, a diskette, or a similar data carrier suitable to store the computer program for electronic access.", "A yet further embodiment of the invention relates to device for noise distribution shaping for signals comprising means for generating a blanking control signal by comparing a received signal comprising transitions with at least one blanking threshold, means for generating a transitions control signal depending on determined transitions of the received signal and zones around the determined transitions, means for adapting the at least one blanking threshold or the received signal according to an offset value depending on the amplitude of the received signal and on the transitions control signal, and means for modifying the noise distribution of the received signal by applying blanking of the received signal under control of the blanking control signal.", "The means for generating transitions control signal may be configured to set the durations of zones around the determined transitions to a constant value.", "The means for generating a transitions control signal may be configured to select the constant value of the zones durations depending on the accuracy of a tracking loop for tracking the received signal.", "Alternatively, the means for generating transitions control signal may be configured to adapt the durations of the zones around the determined transitions during noise distribution shaping.", "The means for generating a blanking control signal may be configured to set the at least one blanking threshold within the zones around the determined transitions to a predefined value, which is selected such that the adapting of the at least one blanking threshold is interrupted within the zones.", "In other words, the adaptation of the blanking thresholds is “paused” within the zones, or the at least one blanking threshold is not offset within the zones.", "Alternatively, means for generating a blanking control signal may be configured to interrupt the adapting of the received signal (samples) within the zones around the determined transitions so that the samples of the received signal are not offset within the zones, and are still fed to the at least one blanking threshold having a predefined value.", "Here, the means for generating a blanking control signal “pause” the adaptation of the received spread spectrum signal within the zones.", "The means for adapting may be further configured to calculate the amplitude of the received signal based on the estimated received power Pest of the received signal and to calculate the offset value from the calculated amplitude of the received signal, particularly by multiplying the square root of the estimated power Pest with a predefined scaling factor α.", "Particularly, the predefined scaling factor α can be positive or negative, constant or time dependent, or the sign of the predefined scaling factor α can change over time as function of the received signal.", "The means for generating a blanking control signal may comprise a comparator circuit with a first input for receiving signal samples and at least one second input for receiving the at least one blanking threshold.", "The means for adapting the at least one blanking threshold or adapting the received signal, respectively, according to an offset value which depends on the amplitude of the received signal may comprise means for offsetting the at least one predefined blanking threshold or the received signal, respectively, with the scaled amplitude of the received signal.", "The means for modifying the noise distribution of the received signal by applying blanking of the received signal under control of the blanking control signal may comprise means for setting a sample of the received signal to a predefined value depending on the blanking control signal.", "Particularly, samples of the received signal, which exceed the blanking thresholds, may be set to 0.The device may be configured to use a set of blanking thresholds, wherein the set comprises at least one blanking threshold for each one of a plurality of received signals.", "The means for generating a transitions control signal may be configured to only determine transitions of the received signal and zones around the determined transitions for consecutive signal states of different polarity.", "The received signal may be a CDMA signal, and the means for adapting may be configured to calculate the offset value by multiplying the square root of the estimated power Pest with a scaling factor being +1 or −1 depending on the chip values of the CDMA signal.", "A yet further embodiment of the invention relates to a GNSS receiver circuitry comprising an analog to digital converter for generating samples of received CDMA signals, a plurality of noise distribution shapers for modifying the noise distribution of the sampled CDMA signals according to the invention and as described herein, and a GNSS signal processor for processing the sampled CDMA signals output by the noise distribution shapers and for outputting chip values of the processed CDMA signals.", "These and other aspects of the invention will be apparent from and elucidated with reference to the embodiments described hereinafter.", "The invention will be described in more detail hereinafter with reference to exemplary embodiments.", "However, the invention is not limited to these exemplary embodiments.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 shows a diagram of a chip stream for a received and a replica signal, when the tracking error is non-zero; FIG.", "2 shows a diagram of the chip stream for the received signal from FIG.", "1 with the chip transitions between consecutive chips; FIG.", "3 shows the diagram of FIG.", "1 with an additional multipath signal which will superimpose onto the received signal; FIG.", "4 shows the diagram of FIG.", "1 with a modified blanking threshold, which is “paused” within zones around each chip transition according to the invention; FIG.", "5 shows the diagram of FIG.", "1 with a modified blanking threshold, which is “paused” within zones around the chip transitions between consecutive chips of different polarity according to the invention; FIG.", "6 shows an embodiment of a GNSS receiver circuitry with a noise distribution shaper according to the invention; and FIG.", "7 shows a flow chart of an embodiment of a noise distribution shaping method for CDMA signals according to the invention.", "DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS In the following, functionally similar or identical elements may have the same reference numerals.", "Absolute values are shown below by way of example only and should not be construed as limiting the invention.", "Even if the following description of the invention is applied to CDMA signals of a GNSS, it should be noted that the invention can generally be applied to any kind of signal comprising transitions and is, therefore, not restricted to CDMA signals.", "The blanking disclosed in the before mentioned European patent application no.", "14290171.9 applies blanking thresholds BTH+ and BTH− with the following values: BTH+=α×(sqrt(Pest))×c(t)+B0 BTH−=α×(sqrt(Pest))×c(t)−B0 Where c(t) equals +1 or −1 according to the chip polarity, α is a scaling factor for example 1, Pest is the estimated power, B0 the blanking threshold without offset (as for a conventional receiver).", "B0 can be set for example to 0.5×σnoise where σnoise represents the standard deviation for the thermal noise.", "Both thresholds are synchronized to the received GNSS signal chip stream (whose amplitude is typically smaller than the standard deviation of the noise), which represents an ideal situation.", "In reality, a GNSS receiver does not know when the exact chip transition occurs, but can only estimate it thanks to tracking loops (DLL, possibly aided with a PLL).", "Such loops will consequently allow determining the positive or negative offset of both thresholds, according to the estimated polarity of the spreading sequence.", "As a consequence, in a real scenario the exact position of the chip transition will be known with the accuracy of the tracking loops.", "Now, at a low Carrier-to-Noise Spectral Density Ratio (C/N0) the corresponding tracking loop performance will consequently influence the setting of the thresholds.", "Furthermore, in case of high dynamic, the delay locked loop (and possibly the phase locked loop) might not react quickly enough and, as a consequence, the offset “transition” might be delayed with respect to the actual/true chip transition of the received signal.", "As a consequence, some of the decisions to blank or not some of the samples might not be optimal around those chip transitions.", "Finally, in presence of multipath and especially strong static multipath, the “delayed multipath” signal will also delay the chip transition, which might also degrade the optimal setting of the thresholds offset if the loops are sensitive to the corresponding additional multipath signal.", "FIG.", "1 represents the chip stream for the received signal 100 and the replica signal 102, when the tracking error is non-zero.", "The two blanking thresholds BTH+ and BTH− are also represented in dashed lines and are synchronized to the replica signal 102.The tracking error is caused either by thermal noise, or by the dynamic or both dynamic and thermal noise.", "FIG.", "2 shows only the chip stream for the received signal 100 with the transitions between consecutive chips (chip transitions).", "As it can be seen, a chip transition occurs also between consecutive chips 112 and 114 of the same polarity.", "FIG.", "3 additionally represents a multipath signal 104 which will superimpose onto the received signal 100 (but not onto the replica).", "All of the reasons motivated the inventors to introduce a zone around the chip transition where no offset, or even no blanking (to do that one solution comprises raising the blanking threshold to a very large value) shall be applied.", "FIGS.", "4 and 5 represents the modified blanking thresholds, by introducing a zone where no blanking is applied.", "The width of this zone is 2×Δ.", "Hence during the period 2×Δ around the chip transition, no offsetting of the blanking thresholds is used.", "It has to be highlighted that the de-activation of the threshold offsetting can also apply at the chip transitions even if the consecutive chip values are identical (same polarity) or not.", "Alternatively, it is also possible to de-active the threshold offsetting around the chip transition only when the polarity of consecutive chips is opposite.", "The width 2×Δ can be adapted during receiver operation.", "For example, if the receiver contains any multipath detection function, which can monitor the multipath environment and confirm the absence of multipath, the 2×Δ could be set very low or even suppressed (no offset de-activation).", "Similarly, if the receiver works at an higher (C/N0) or in absence of dynamic during a given period of time, again the 2×Δ could be set very low or even suppressed.", "Consequently, the width 2×Δ can be for example adapted by the tracking loops.", "Of course, it can also be set constant as a configuration parameter of the receiver and particularly the adaptive blanker.", "In FIG.", "4, each chip transition comprises a zone 106, within the offsetting of the blanking threshold is “paused” or interrupted, also within the zone around the chip transition between two consecutive chips with the same polarity.", "However, it is also possible to not “pause” or interrupt the offsetting of the blanking threshold between two consecutive chips of the same polarity, as shown in the diagram of FIG.", "5.FIG.", "6 shows a block diagram of a GNSS receiver circuitry 10 comprising a noise distribution shaper according to the invention.", "The shown circuitry 10 comprises a RF front end circuitry 14 for filtering and down converting CDMA signals received from GNSS signals into a baseband for further processing, an ADC (Analog to Digital Converter) 16 for sampling the down converted CDMA signals (an AGC (Automatic Gain Control) (not shown) can be placed between the RF front end circuitry 14 and the ADC 16) and converting the analog samples of the CDMA signals into digital values, a noise distribution shaper 18 according to the invention for shaping the noise distribution of the digitized CDMA signal samples of one of the plurality of the received CDMA signals, and a GNSS signal processor 26 for correlating the received CDMA signals with spreading sequences or chip values used to encode the CDMA signals and processing the CDMA signals for determining and outputting positioning data 28.It should be noted that the noise distribution shaping can also be applied directly in RF, and is therefore not restricted to the baseband as described before.", "In the following, the implementation of the noise distribution shaper 18 is described in detail.", "The digitized CDMA samples output by the ADC 16 are input to a blanker 20 and an input of a comparator circuit 22.The comparator circuit 22 further receives a first adaptive blanking threshold BTH−(i) and a second adaptive blanking threshold BTH+(i), which are both output from a blanking threshold generator 24.The adaptive blanking thresholds BTH−(i) and BTH+(i) are assigned to one signal (index i) of the plurality of the I received CDMA signals.", "In other words, each received CDMA signal usually has its own dedicated adaptive blanking thresholds.", "Also, less or more than two adaptive blanking thresholds may be provided.", "Furthermore, for each chip value taken at instant k, the blanking thresholds BTH−(i) and BTH+(i) will be modified according to this binary chip value.", "Now the time dependency is considered implicitly in the example to ease readability.", "The blanking threshold generator 24 receives from the GNSS signal processor 26 the chip values, which are used by the processor to decode and despread the received CDMA signals.", "For example, if the processor 26 is able to decode four (I=4) CDMA signals among the plurality of received CDMA signals, it outputs the four chip values corresponding to the spreading sequences assigned to the four received CDMA signals and used to decode them by the processor 26.It should be noted that in such case four different adaptive blanking threshold generators 24 are required since each block will be adapted to the chip value of each sequence (in FIG.", "6, only one generator block 24 is shown).", "The blanking threshold generator 24 receives a chip transitions control signal, which is generated by a chip transitions control signal generator 17.The generator 17 receives from the GNSS signal processor 26 a signal indicating the estimated transitions of chips and a tracking error of the real GNSS signal.", "The GNSS signal processor 26 can estimate the chip transitions with a tracking loop, preferably a DLL as it may be used in the signal processor to track the received GNSS signal.", "In addition to the DLL, a PLL may be used, which can also be applied to estimate the chip transitions.", "From the signal indicating estimated transitions of chips in a received GNSS signal and the tracking error of an applied tracking loop, the generator 17 generates and outputs the chip transitions control signal containing the zone duration 2×Δ around each estimated chip transition to the threshold generator 24, wherein the width of the zone can vary depending on the dynamic foreseen of the application type, for example it can differ for pedestrian and airborne users.", "Furthermore, in case two consecutive chips have the same polarity (‘+|+’ or ‘−|−’), the width of the duration of zone around the chip transition can be set to 0, meaning that the offset of the blanking threshold is still applicable for such transitions with identical chip polarity or equivalently that the de-activation of the offset is cancelled.", "The blanking threshold generator 24 generates with the received chip values the first adaptive blanking threshold BTH−(i) and the second adaptive blanking threshold BTH+(i).", "The blanking thresholds BTH+(i) and BTH−(i) may be generated by offsetting predefined blanking thresholds BTHpre+ and BTHpre− with the scaled amplitude of the respective CDMA signal i.", "The amplitude of the offsets applied to the predefined blanking thresholds BTHpre+ and BTHpre− are calculated from the estimated power (Pest) of the received signal based on the samples provided by the Analog-to-Digital Converter (ADC), from block 16, multiplied with a scaling factor also function of the binary chip value.", "Two scaling factors α+ and α− are respectively deduced for the positive and negative chip value.", "The predefined blanking thresholds BTHpre+ and BTHpre− may be for example selected depending on the environment of operation of the GNSS receiver and particularly be configured depending on the occurrence of pulsed interferences such as generated by vehicle ignition systems, power lines, heavy current switches or microwave ovens.", "For example, in an environment with strong pulsed interferences, such as in the neighborhood of vehicle ignition systems or power lines, the predefined blanking thresholds may be set with a higher value than in environments with weaker pulsed interferences.", "For the selection of predefined blanking thresholds suitable for a certain environment, the strength and frequency of occurrence of pulsed interferences in the received CDMA signals may be determined, and depending thereon suitable predefined blanking thresholds may be determined.", "The offsetting of the predefined blanking thresholds BTHpre+ and BTHpre− may comprise adding the estimated received power Pest multiplied with a positive scaling factor α+ for positive chip value, or adding the estimated received power Pest multiplied with a scaling negative factor α− for negative chip value: Hence for positive chip values the adapted blanking thresholds are given by: BTH−(i)=BTHpre−+α+(i)(sqrt(Pest)) BTH+(i)=BTHpre++α+(i)(sqrt(Pest)) And for negative chip values the adapted blanking thresholds are given by: BTH−(i)=BTHpre−+α−(i)(sqrt(Pest)) BTH+(i)=BTHpre++α−(i)(sqrt(Pest)) The offsetting of the predefined blanking thresholds BTHpre+ and BTHpre− is further controlled by the chip transitions control signal received from the chip transitions control signal generator 17.During the zone of duration 2×Δ around each estimated chip transition as indicated by the chip transitions control signal, the blanking threshold generator 24 sets the adaptive blanking thresholds BTH+(i) and BTH−(i) to β×BTHpre+ and β×BTHpre−, where β is a scaling factor.", "By doing this the blanking threshold is applied without offset.", "Hence during the zone duration 2×Δ the blanking thresholds are given by: BTH−(i)=β×BTHpre− and BTH+(i)=β×BTHpre+ for both positive and negative chip values An alternatively scheme for the zone around the chip transition could be: For positive chip values the blanking thresholds are given by: BTH−(i)=−LVAL BTH+(i)=+LVAL And for negative chip values the blanking thresholds are given by: BTH−(i)=−LVAL BTH+(i)=+LVAL LVAL is a large value, which is selected such that the amplitudes of CDMA samples of CDMA signal i do not exceed LVAL.", "By doing this the blanking is deactivated during the zone around the chip transition.", "Alternatively to considering the chip transitions control signal supplied to the threshold generator 24, the chip transitions control signal may also be directly supplied to the comparator circuit 22, as outlined in FIG.", "6 by the dashed arrow from block 17 to block 22.Then the supply of chip transition supplied from block 17 to block 24 would not be necessary.", "Then, the comparator circuit 22 directly processes the chip transitions control signal when generating a blanking control signal NBCTRL(i) as described in the following.", "The adaptive blanking thresholds BTH+(i) and BTH−(i) are sent to second inputs of the comparator circuit 22, which receives on its first input the digitized CDMA samples from the ADC 16.The comparator circuit 22 compares the amplitudes (algebraic values) of the digitized CDMA samples with the adaptive blanking thresholds BTH+(i) and BTH−(i) and generates depending on the comparison the blanking control signal NBCTRL(i), which controls the blanker 20.The comparator circuit 22 may generate the blanking control signal NBCTRL(i) for example as follows: amplitudes of CDMA samples of CDMA signal i>BTH+(i)→NBCTRL(i)=+1 amplitudes of CDMA samples of CDMA signal i<BTH−(i)→NBCTRL(i)=−1 amplitudes of CDMA samples of CDMA signal i<BTH+(i) and >BTH−(i)→NBCTRL(i)=0 The blanker 20 sets the samples of the CDMA signals received at its input to a predefined value such as zero as long as the noise blanking control signal NBCTRL(i) is +1 or −1, and passes the received digitized CDMA signals from its input to its output if the blanking control signal NBCTRL(i) is 0.During an indicated chip transition (for example by means of the chip transitions control signal from the generator 17 or immediately via the adaptive blanking thresholds BTH+(i) and BTH−(i) from the threshold generator 24 if the comparator 22 does not receive the chip transitions control signal), the comparator circuit 22 outputs a blanking control signal NBCTRL(i), which is either 0 without any blanking (which is equivalent to setting the adaptive blanking thresholds BTH+(i) and BTH−(i) to a very large value) or +1/−1 with blanking (in the case of the offsetting of the blanking thresholds BTH+(i) and BTH−(i) is not applied, and those thresholds equals BTH−(i)=β×BTHpre− and BTH+(i)=β×BTHpre+).", "The above example is given for two blanking thresholds BTH+ and BTH− (N=2).", "In the following, a brief example for the case of a larger N=4 for a CDMA signal i is given (hereby BTH(n, i) means blanking threshold n for CDMA signal i): CDMA signal i<BTH(1,i)→NBCTRL(i)=+1.BTH(1,i)<CDMA signal i<BTH(2,i)→NBCTRL(i)=0.BTH(2,i)<CDMA signal i<BTH(3,i)→NBCTRL(i)=+1.CDMA signal i>BTH(4,i)→NBCTRL(i)=+1.Again the proposed control low for the NBCTRL(i) based on a comparison with the 4 thresholds is just one example.", "The blanking control signal for the blanking thresholds BTH(n, i) is adapted for the ith tracked CDMA signal among I signals.", "As a consequence, as many blanking blocks as there are tracked signals (I) are required.", "Alternatively, a single control block fed with the different chip values for the I CDMA signals can be provided.", "However, this single control block must then be able to handle the blanking thresholds BTH(n, i) for the ith CDMA signal, for example by applying multiplexing inside the block.", "FIG.", "7 shows a flowchart of a method for noise distribution shaping for I CDMA signals according to the invention, which can be implemented as a computer program to be executed by a processor.", "The term “steps” used in the following description does not mean that the steps are performed in a certain sequence, since the single steps can also be performed in parallel.", "Thus, “steps” must be understood as “acts performed by the method.” The method receives in step S0 digitized CDMA signal samples of the ith CDMA signal from the ADC 16.In step S11, the method receives chip transitions and a tracking error of the ith CDMA signal and generates a chip transitions control signal.", "In step S12, the chip values of the ith CDMA signal are provided, which are known a priori and stored in a memory.", "In step S13 the ith CDMA signal from the ADC 16 is provided in order to estimate the power of the ith received signal.", "The scaled estimated chip amplitudes are then used in step S14 to offset predefined blanking thresholds BTHpre(i) to generate a set of blanking thresholds BTH+(i) and BTH−(i) for each CDMA signal.", "The offsetting in step S14 can be performed depending on the chip transitions control signal provided through step S11: during each estimated chip transition, a zone with a duration 2×Δ is defined around each estimated chip transition and, during each zone, the blanking thresholds BTH+(i) and BTH−(i) for each CDMA signal i are set to a predefined value, which is selected such that the adapting of the at least one blanking threshold is interrupted within the zones, while “out of the chip transition zones” the blanking thresholds BTH(i) for each CDMA signal are offset with the scaled estimated amplitude.", "With the set of blanking thresholds BTH(i) and the received digitized CDMA signal samples, the method generates in step S10 a blanking control signal for each CDMA signal i, for example by a comparison as described above.", "Alternatively, the offsetting in step S14 can be performed without considering the chip transitions control signal (in fact, the chip transitions control signal generated in step S11 must not be provided to step S14) and the chip transitions control signal can be directly provided through step S11 to step S10 (dashed arrow from step S11 to step S10 in FIG.", "7).", "Then, the chip transitions control signal is used for the generation of the blanking control signal, namely for interrupting or pausing the adapting of the received spread spectrum coded signal within the zones around the determined chip transitions as described above.", "In step S16, the noise distribution of the received samples of the ith CDMA signal is shaped by a blanking process controlled by the ith blanking control signal generated in step S10.The CDMA signal samples with shaped noise distribution are finally output to the GNSS signal processor 26 for further processing.", "Simulations performed by the inventors have shown that by introducing the corresponding zones around the chip transitions for the blanker, the improvement in (C/N0) is reduced with respect to the case with blanking thresholds permanently offset but still much better than the case without adaptive blanking thresholds.", "Despite this reduction in absolute (C/N0) improvement, the corresponding receiver will gain in robustness for low (C/N0), high dynamic and strong multipath environments.", "The present invention constitutes an extension of the blanking approach disclosed in the European patent application no.", "14290171.9.It extends the range of applicability, especially for typical environment with multipath or for receiver having large dynamic.", "The present invention allows reducing the degradation of the SNIR of a received signal, particularly a CMDA signal, when there are no pulsed interferences, by offsetting the blanking thresholds or the signal depending on the amplitude of the signal, for example with the scaled amplitude (the amplitude can be positive or negative according to the chip value) of a received CDMA signal, and by comparing the amplitude (algebraic value) of samples of the received signal to the blanking thresholds.", "The present invention can be used for receivers for navigation and communication applications.", "In general, the invention is of interest for all terrestrial or space based applications in telecommunication, or more generally for all kinds of signal transmissions where the signal is buried in high-level noise.", "While at least one exemplary embodiment of the present invention(s) is disclosed herein, it should be understood that modifications, substitutions and alternatives may be apparent to one of ordinary skill in the art and can be made without departing from the scope of this disclosure.", "This disclosure is intended to cover any adaptations or variations of the exemplary embodiment(s).", "In addition, in this disclosure, the terms “comprise” or “comprising” do not exclude other elements or steps, the terms “a” or “one” do not exclude a plural number, and the term “or” means either or both.", "Furthermore, characteristics or steps which have been described may also be used in combination with other characteristics or steps and in any order unless the disclosure or context suggests otherwise.", "This disclosure hereby incorporates by reference the complete disclosure of any patent or application from which it claims benefit or priority.", "REFERENCE NUMERALS AND ACRONYMS 10 GNSS receiver circuitry 12 antenna 14 RF front end circuitry 16 ADC 17 chip transitions control signal generator 18 noise distribution shaper 20 blanker 22 comparator circuit 24 blanking threshold generator 26 GNSS signal processor 28 GNSS output data 100 received GNSS signal 102 replica GNSS signal 104 multipath signal 106 zones around chip transitions for “pausing” or interrupting of the offset of the blanking threshold 108-114 consecutive chips ADC Analog to Digital Converter BTH Blanking Threshold CDMA Code Division Multiple Access C/N0 Carrier-to-Noise Spectral Density Ratio GNSS Global Navigation Satellite System DLL Delay Locked Loop NBCTRL Noise Blanking Control PLL Phase Locked Loop RF Radio Frequency SNIR Signal-to-Noise and Interference Ratio" ] ]
Patent_15872628
[ [ "POSITION DETECTING DEVICE", "The invention allows size reduction of a sensor of a position detecting device of a capacitive system, which detects a position indicated by an indicator.", "The sensor has plural electrode conductors that are disposed adjacent to each other and are configured to receive a signal from the indicator on a first surface of a substrate having the first surface and a second surface opposed to each other.", "The position detecting device includes a signal processing circuit including a differential amplifier circuit that calculates a difference between signals from at least two of the plural electrode conductors.", "Plural connecting lines are formed on the second surface of the substrate.", "The plural connecting lines each have one end connected to one of the plural electrode conductors disposed on the first surface by a through-hole or a via formed through the substrate, and the other end connected to a line-concentrated part." ], [ "1.A device for detecting a position of an object in a detection area, comprising: a panel providing a horizontal surface; an electrode layer arranged underneath the panel and formed of a plurality of block-shaped conductor patterns laid within the detection area; a wiring layer arranged underneath the electrode layer and formed of a plurality of routing lines extending respectively from the plurality of block-shaped conductor patterns within the detection area toward a collection area outside the detection area; vias that respectively connect the plurality of block-shaped conductor patterns within the detection area to the plurality of routing lines in a direction perpendicular to the horizontal surface; and circuitry which is coupled to the collection area and which, in operation, detects the position of the object in the detection area based on electric charges respectively induced in the plurality of block-shaped conductor patterns.", "2.The device of claim 1, wherein each of the vias is positioned within an area of each of the plurality of block-shaped conductor patterns.", "3.The device of claim 1, wherein the routing lines extend in a direction perpendicular to a peripheral edge of the detection area.", "4.The device of claim 3, wherein the routing lines are grouped into bundles.", "5.The device of claim 1, wherein the object is an active pen configured to transmit electric signals, and the plurality of block-shaped conductor patterns laid in the electrode layer constitute a shield for the routing lines arranged in the wiring layer underneath the electrode layer.", "6.The device of claim 1, wherein first sub-sets of conductor patterns including the plurality of block-shaped conductor patterns are connected along a first direction to form a first set of elongated electrodes each extending in the first direction, and the routing lines extend in a second direction different from the first direction.", "7.The device of claim 6, wherein second sub-sets of conductor patterns are connected along the second direction, via connectors in the wiring layer underneath the electrode layer, to form a second set of elongated electrodes each extending in the second direction.", "8.The device of claim 1, comprising a display, wherein the panel is arranged underneath the display.", "9.A device for detecting a position of a position indicator based on an electric signal transmitted from the position indicator, the device comprising: a panel providing a surface; first electrodes connected along a first direction within the panel; second electrodes connected along a second direction different from the first direction within the panel; circuitry which is coupled to the first and second electrodes and which, in operation, detects the position of the position indicator based on a distribution of reception levels of the electric signal transmitted from the position indicator at defined ones of the first and second electrodes; and floating electrodes that are arranged among the first and second electrodes and are not electrically connected to any of the first and second electrodes.", "10.The device of claim 9, wherein the floating electrodes smooth out a change in the reception levels of the electric signal transmitted from the position indicator detected at the defined ones of the first and second electrodes.", "11.The device of claim 10, wherein the floating electrode suppresses the reception level at the electrode closest to the position indicator to thereby decrease a difference in the reception levels at the electrode closest to the position indicator and the electrode second-closest to the position indicator.", "12.The device of claim 10, wherein the floating electrode increases the reception level at the electrode that is second-closest to the position indicator.", "13.The device of claim 10, wherein the floating electrode is positioned within an area defined by an outer periphery of the first electrode.", "14.The device of claim 10, wherein the floating electrode is positioned between the first electrode and the second electrode that are adjacent to each other." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> BRIEF SUMMARY <EOH>It is desirable to provide a position detecting device of a capacitive system that can solve the above-described problems.", "To solve the above-described problems, one aspect of the invention provides a position detecting device of a capacitive system that detects a position indicated by an indicator according to a signal transmitted from the indicator.", "The position detecting device includes a substrate having a first surface and a second surface opposed to the first surface, a plurality of electrode conductors that are disposed adjacent to each other on the first surface of the substrate and configured to receive the signal transmitted from the indicator, and a signal processing circuit including a differential amplifier circuit configured to calculate a difference between at least two electrode conductors selected from the plurality of electrode conductors.", "The signal processing circuit detects the position indicated by the indicator from an output of the differential amplifier circuit.", "The position detecting device further includes a plurality of connecting lines that are disposed close to each other on the second surface of the substrate.", "Each of the connecting lines has one end connected to a respective one of the plurality of electrode conductors disposed on the first surface by a through-hole or a via, and a line-concentrated part that is connected to the other end of the respective one of the plurality of connecting lines and that serves as a connection terminal with the signal processing circuit.", "Furthermore, connecting parts, which are provided to electrically connect conductor patterns via through-holes formed in the substrate to thereby form an electrode conductor among the plurality of electrode conductors, are arranged so as to extend along a direction that is not orthogonal to the connecting lines (e.g., the connecting parts extend in parallel with the connecting lines).", "In the aspect of the invention having the above-described configuration, the plural electrode conductors are formed adjacent to each other on the first surface of the substrate.", "In addition, the connecting lines for connecting the plural electrode conductors to the signal processing circuit are disposed close to each other on the second surface of the substrate that is opposite to the first surface of the substrate in which the plural electrode conductors are formed.", "Therefore, the connecting lines are electrostatically shielded by the plural electrode conductors, and reception of a transmitted signal from the indicator, such as an indicating pen, by the connecting lines is prevented or alleviated.", "Furthermore, the connecting lines are disposed close to each other.", "Moreover, the connecting parts for electrically connecting the conductor patterns via the through-holes formed in the substrate to thereby form an electrode conductor among the plural electrode conductors are so formed as to extend along a direction that is not orthogonal to the connecting lines.", "Thus, the connecting lines are disposed close to each other even at the part where the above-described connecting parts exist.", "Accordingly, even when noise is superimposed on the connecting lines, the noise is in a similar state in the plural connecting lines.", "Thus, the noise superimposed on the connecting lines is removed by performing a difference calculation on signals from the plural electrode conductors in the differential amplifier circuit of the signal processing circuit.", "For the above reasons, according to the above-described aspect of the invention, in a position detecting device of a capacitive system, the position indicated by the indicator can be correctly detected when the connecting lines are provided on the second surface of the substrate that is opposite to the first surface of the substrate on which the plural electrode conductors are formed.", "In one preferred mode of the position detecting device of the above-described aspect of the invention, each of the plurality of electrode conductors are formed to extend along a first direction and are arranged close to each other in a second direction that intersects the first direction.", "Furthermore, the plural connecting lines are formed to extend along the second direction.", "According to the preferred mode, the plural connecting lines for the plural electrode conductors, which are connected by the through-holes, are formed to extend along the second direction that intersects the first direction, along which the plural electrode conductors extend.", "In the case of forming the connecting lines along the first direction, which is the extension direction of the plural electrode conductors, the connecting lines need to be formed across the whole surface in the second direction, which is the arrangement direction of the plural electrode conductors.", "However, in the preferred mode, the forming direction of the connecting lines is in the second direction that intersects the first direction, along which the plural electrode conductors extend.", "Therefore, in the preferred mode, the positions of the through-holes can be made close to each other in the second direction in the plural electrode conductors.", "Therefore, it is easy to form the connecting lines close to each other in parallel.", "As a result, according to the above-described preferred mode, for a position detecting device of a capacitive system, the position indicated by the indicator can be correctly detected with alleviation of noise when the connecting lines are provided opposed to the plural electrode conductors on the second surface on the opposite side to the first surface of the substrate on which the plural electrode conductors are formed, in the position detecting sensor.", "According to the invention, in the position detecting device of the capacitive system, the connecting lines can be provided on the second surface of the substrate that is opposite to the first surface of the substrate on which the plural electrode conductors are formed, while ensuring of correct detection of the position indicated by the indicator.", "As such, the connecting lines formed on the second surface of the substrate do not need to be led around to the peripheral part of the substrate.", "This can eliminate an interconnect area in which the connecting lines are led around and correspondingly reduce the size of the substrate, which can prevent the lowering of convenience and design property." ], [ "BACKGROUND Technical Field This invention relates to a position detecting device of a capacitive system that detects a position indicated by a position indicator by receiving a signal from the position indicator.", "Description of the Related Art Tablet information terminals equipped with touch panels are commonly used.", "For example, the electrostatic induction system disclosed in Patent Document 1 (Japanese Patent Laid-Open No.", "Hei 08-179871) is widely used.", "In Patent Document 1, plural electrode conductors are disposed vertically and horizontally on a substrate surface of a position detecting sensor.", "The intersections formed by these electrode conductors are sequentially selected and the signal intensity is obtained.", "Based on the signal distribution, a position indicated by, for example, a position indicator, such as a pen type position indicator (hereinafter, referred to as an indicating pen), is obtained.", "In Patent Document 1, the indicating pen internally includes an oscillator circuit.", "An oscillation signal with a predetermined frequency from the oscillator circuit is applied to the plural electrode conductors of the position detecting sensor.", "Furthermore, in the position detecting device, the position indicated by the indicating pen on the input surface of the position detecting sensor is detected from the signal intensity (signal level) of an induced signal obtained from each of the electrode conductors disposed vertically and horizontally.", "The above-described device is frequently used in combination with a display device, such as a liquid crystal display (LCD).", "In this case, noise generated by the display device gets mixed in with the signal such that the position of the indicator cannot be correctly obtained or an incorrect position is detected.", "This results in erroneous operation in some cases.", "As such, denoising is an important issue for a position detecting device of an electrostatic induction system.", "A differential amplifier circuit is often used in related arts for denoising.", "Specifically, two electrode lines disposed along the same direction are simultaneously selected.", "One of the electrodes is connected to the positive-side input of the differential amplifier circuit and the other electrode is connected to the negative-side input of the differential amplifier circuit.", "Therefore, the noise component is canceled and only a signal difference generated by the indicator, such as an indicating pen, is detected.", "Examples of this method include techniques described in Patent Document 2 (Japanese Patent Laid-Open No.", "Hei 5-6153) and Patent Document 3 (Japanese Patent Laid-Open No.", "Hei 10-20992).", "For a position detecting sensor of the related arts, the above-described plural electrode conductors are provided by forming conductor patterns as shown in FIG.", "11 on a substrate 1 composed of, for example, resin.", "Specifically, in FIG.", "11, formed on the substrate 1 with, for example, a rectangular shape are plural first electrode conductors (hereinafter, referred to as Y-electrode conductors) Y1, Y2, .", ".", ".", ", Ym (m is an integer equal to or larger than two) extending along a horizontal direction (X-axis direction), and plural second electrode conductors (hereinafter, referred to as X-electrode conductors) X1, X2, .", ".", ".", ", Xn (n is an integer equal to or larger than two) extending along a direction intersecting the horizontal direction, specifically a vertical direction (Y-axis direction) orthogonal to the horizontal direction.", "In this case, an area in which the intersections of the plural Y-electrode conductors Y1 to Ym and the plural X-electrode conductors X1 to Xn are formed (area surrounded by a dotted line 2s in FIG.", "11) serves as a detection area 2 for an indicator.", "Furthermore, as shown in FIG.", "11, the substrate 1 includes, as projecting parts, a Y-electrode terminal 3 and an X-electrode terminal 4 forming connection terminals with an external signal processing circuit.", "In the Y-electrode terminal 3, conductor patterns extended from each of the plural Y-electrode conductors Y1 to Ym are concentrated by being routed along the periphery of the substrate 1.Similarly, in the X-electrode terminal 4, conductor patterns extended from each of the plural X-electrode conductors X1 to Xn are concentrated by being routed along the periphery of the substrate 1.As described above, in the related-art position detecting sensor, lead conductor patterns formed by being extended from the respective electrode conductors need to be routed around along the periphery of the substrate 1 to thereby concentrate the plural Y-electrode conductors Y1 to Ym and the plural X-electrode conductors X1 to Xn in the Y-electrode terminal 3 and the X-electrode terminal 4, respectively.", "Thus, an interconnect area 5 (indicated by the hatched lines in FIG.", "11) for the lead conductor patterns (connecting lines), surrounded by the dotted line 5s, needs to be provided in FIG.", "11.Accordingly, the related arts have a problem that the substrate 1 is larger than the detection area 2 for the indicator because of the existence of the interconnect area 5.This results in lower convenience and design property.", "In related arts, in the case of a position detecting device of an electromagnetic induction system in which X-direction and Y-direction loop coils are formed in a position detecting sensor and used, an attempt to eliminate the interconnect area 5 of the connecting lines is made by forming the connecting lines on the back surface side (side on which the loop coils are not formed) of the substrate by using through-holes.", "This is allowed because, in the case of the electromagnetic induction system, components that receive a signal from an indicating pen are the loop coils and it is difficult for the connecting lines to receive the signal from the indicating pen.", "However, in the case of a position detecting sensor of a capacitive system, the connecting lines also receive the signal from the indicating pen.", "Therefore, there is a problem that it is difficult to detect the position of the indicator if the connecting lines are formed on the back surface side (side on which the X-electrode conductors and Y-electrode conductors are not formed) of the substrate by simply using through-holes.", "For a position detecting sensor of a capacitive system, a differential amplifier circuit, which performs differential amplification of received signals from two electrode conductors on which similar noise is superimposed, is used to remove noise that is generated in the sensor from the received signals obtained from the electrode conductors.", "It is preferable that the distance between the two electrode conductors, each connected to a respective one of the non-inverting input terminal and the inverting input terminal of the differential amplifier circuit, are as short as possible.", "If there is a large distance between the two electrode conductors the similarity of noise is lost and the effect of the enhancement in the noise resistance obtained by the differential amplification cannot be achieved.", "The circuit scale also becomes large.", "BRIEF SUMMARY It is desirable to provide a position detecting device of a capacitive system that can solve the above-described problems.", "To solve the above-described problems, one aspect of the invention provides a position detecting device of a capacitive system that detects a position indicated by an indicator according to a signal transmitted from the indicator.", "The position detecting device includes a substrate having a first surface and a second surface opposed to the first surface, a plurality of electrode conductors that are disposed adjacent to each other on the first surface of the substrate and configured to receive the signal transmitted from the indicator, and a signal processing circuit including a differential amplifier circuit configured to calculate a difference between at least two electrode conductors selected from the plurality of electrode conductors.", "The signal processing circuit detects the position indicated by the indicator from an output of the differential amplifier circuit.", "The position detecting device further includes a plurality of connecting lines that are disposed close to each other on the second surface of the substrate.", "Each of the connecting lines has one end connected to a respective one of the plurality of electrode conductors disposed on the first surface by a through-hole or a via, and a line-concentrated part that is connected to the other end of the respective one of the plurality of connecting lines and that serves as a connection terminal with the signal processing circuit.", "Furthermore, connecting parts, which are provided to electrically connect conductor patterns via through-holes formed in the substrate to thereby form an electrode conductor among the plurality of electrode conductors, are arranged so as to extend along a direction that is not orthogonal to the connecting lines (e.g., the connecting parts extend in parallel with the connecting lines).", "In the aspect of the invention having the above-described configuration, the plural electrode conductors are formed adjacent to each other on the first surface of the substrate.", "In addition, the connecting lines for connecting the plural electrode conductors to the signal processing circuit are disposed close to each other on the second surface of the substrate that is opposite to the first surface of the substrate in which the plural electrode conductors are formed.", "Therefore, the connecting lines are electrostatically shielded by the plural electrode conductors, and reception of a transmitted signal from the indicator, such as an indicating pen, by the connecting lines is prevented or alleviated.", "Furthermore, the connecting lines are disposed close to each other.", "Moreover, the connecting parts for electrically connecting the conductor patterns via the through-holes formed in the substrate to thereby form an electrode conductor among the plural electrode conductors are so formed as to extend along a direction that is not orthogonal to the connecting lines.", "Thus, the connecting lines are disposed close to each other even at the part where the above-described connecting parts exist.", "Accordingly, even when noise is superimposed on the connecting lines, the noise is in a similar state in the plural connecting lines.", "Thus, the noise superimposed on the connecting lines is removed by performing a difference calculation on signals from the plural electrode conductors in the differential amplifier circuit of the signal processing circuit.", "For the above reasons, according to the above-described aspect of the invention, in a position detecting device of a capacitive system, the position indicated by the indicator can be correctly detected when the connecting lines are provided on the second surface of the substrate that is opposite to the first surface of the substrate on which the plural electrode conductors are formed.", "In one preferred mode of the position detecting device of the above-described aspect of the invention, each of the plurality of electrode conductors are formed to extend along a first direction and are arranged close to each other in a second direction that intersects the first direction.", "Furthermore, the plural connecting lines are formed to extend along the second direction.", "According to the preferred mode, the plural connecting lines for the plural electrode conductors, which are connected by the through-holes, are formed to extend along the second direction that intersects the first direction, along which the plural electrode conductors extend.", "In the case of forming the connecting lines along the first direction, which is the extension direction of the plural electrode conductors, the connecting lines need to be formed across the whole surface in the second direction, which is the arrangement direction of the plural electrode conductors.", "However, in the preferred mode, the forming direction of the connecting lines is in the second direction that intersects the first direction, along which the plural electrode conductors extend.", "Therefore, in the preferred mode, the positions of the through-holes can be made close to each other in the second direction in the plural electrode conductors.", "Therefore, it is easy to form the connecting lines close to each other in parallel.", "As a result, according to the above-described preferred mode, for a position detecting device of a capacitive system, the position indicated by the indicator can be correctly detected with alleviation of noise when the connecting lines are provided opposed to the plural electrode conductors on the second surface on the opposite side to the first surface of the substrate on which the plural electrode conductors are formed, in the position detecting sensor.", "According to the invention, in the position detecting device of the capacitive system, the connecting lines can be provided on the second surface of the substrate that is opposite to the first surface of the substrate on which the plural electrode conductors are formed, while ensuring of correct detection of the position indicated by the indicator.", "As such, the connecting lines formed on the second surface of the substrate do not need to be led around to the peripheral part of the substrate.", "This can eliminate an interconnect area in which the connecting lines are led around and correspondingly reduce the size of the substrate, which can prevent the lowering of convenience and design property.", "BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS FIG.", "1 is a diagram for explaining an overall outline of position detecting devices according to embodiments of the invention; FIG.", "2 is a diagram of one example of a sensor used for a position detecting device according to a first embodiment of the invention, as viewed from the front surface side of a substrate; FIG.", "3 is a diagram of one example of the sensor used for the position detecting device according to the first embodiment of the invention, as viewed from the back surface side of the substrate; FIG.", "4 is a partial enlarged view of one example of the sensor used for the position detecting device according to the first embodiment of the invention, as viewed from the front surface side of the substrate; FIG.", "5 is a partial enlarged view of one example of a sensor used for a position detecting device according to a second embodiment of the invention, as viewed from the front surface side of a substrate; FIG.", "6 is a diagram for explaining the shape of the substrate of one example of the sensor used for the position detecting device according to the second embodiment of the invention; FIGS.", "7A and 7B are diagrams for explaining one example of a sensor used for a position detecting device according to a third embodiment of the invention; FIGS.", "8A to 8D are diagrams for explaining another example of a conductor pattern of the sensor used for the position detecting devices according to the embodiments of the invention; FIGS.", "9A to 9D are diagrams for explaining another example of the conductor pattern of the sensor used for the position detecting devices according to the embodiments of the invention; FIGS.", "10A to 10D are diagrams for explaining another example of the conductor pattern of the sensor used for the position detecting devices according to the embodiments of the invention; and FIG.", "11 is a diagram for explaining a position detecting device of a related art.", "DETAILED DESCRIPTION First Embodiment FIG.", "1 is a diagram showing a schematic configuration of a position detecting device according to a first embodiment of the invention.", "In FIG.", "1, the position detecting device has a position detecting sensor 10 (hereinafter, abbreviated as the sensor for simplification) and a signal processing circuit 20 for detecting a position indicated by an indicating pen 40 based on a signal received by the sensor 10.The sensor 10 includes a first electrode conductor group 12 and a second electrode conductor group 13 on a substrate 11 composed of, for example, resin.", "In this example, the substrate 11 is a flat plate having a rectangular shape and has a front surface 11a as a first surface and a back surface 11b (see FIG.", "3) as a second surface opposed to each other.", "The first electrode conductor group 12 is obtained by juxtaposing plural first electrode conductors 12Y1, 12Y, .", ".", ".", ", 12Ym, extending along the horizontal direction (X-axis direction) and separated by predetermined intervals such that they are not electrically connected to each other.", "The second electrode conductor group 13 is obtained by juxtaposing plural second electrode conductors 13X1, 13X2, .", ".", ".", ", 13Xn, extending along a direction that intersects the first electrode conductors 12Y1 to 12Ym (the vertical direction (Y-axis direction) orthogonal to the first electrode conductors 12Y1 to 12Ym in this example) and separated by predetermined intervals.", "The first electrode conductors 12Y1 to 12Ym and the second electrode conductors 13X1 to 13Xn are both formed on the front surface 11a of the substrate 11.In the first embodiment, as will be described later, all of the first electrode conductors 12Y1 to 12Ym, including the intersecting parts (see 32Y in FIG.", "4) with the second electrode conductors 13X1 to 13Xn, are formed on the front surface 11a of the substrate 11.On the other hand, for the second electrode conductors 13X1 to 13Xn, the intersecting parts (see 34X in FIG.", "4) with the first electrode conductors 12Y1 to 12Ym are electrically connected, via through holes, on the side of the back surface 11b of the substrate 11.Furthermore, in the first embodiment, projecting parts 14A and 15A, which form a line-concentrated part 14 for the second electrode conductor group 13 and a line-concentrated part 15 for the first electrode conductor group 12, respectively, are formed on one end side of the rectangular substrate 11 in the Y-axis direction.", "The projecting parts 14A and 15A, at which the line-concentrated parts 14 and 15 are formed, serve as connectors for connecting to the signal processing circuit 20.The line-concentrated part 14 for the second electrode conductor group 13 is provided on the side of the front surface 11a of the substrate 11 and the line-concentrated part 15 for the first electrode conductor group 12 is provided on the back surface side of the substrate 11.Furthermore, the line-concentrated part 15 for the first electrode conductor group 12 is electrically connected to each of the first electrode conductors 12Y1 to 12Ym via the through-holes.", "As described above, the position detecting device of the first embodiment forms a position detecting device of a capacitive system that includes the sensor in which the first electrode conductor group 12 and the second electrode conductor group 13 are so disposed that the extension direction of the first electrode conductor group 12 is orthogonal to the extension direction of the second electrode conductor group 13.Furthermore, the position detecting device detects a position indicated by the indicating pen 40 based on change in the capacitance at the intersections of the first electrode conductors 12Y1 to 12Ym and the second electrode conductors 13X1 to 13Xn.", "The indicating pen 40 internally includes an oscillator circuit 41.The oscillator circuit 41 is a circuit for generating a signal with a frequency of, for example, 1.8 MHz.", "The indicating pen 40 transmits the signal generated by the oscillator circuit 41 from a pen tip part 42 externally.", "The sensor 10 receives the signals transmitted from the indicating pen 40 by the first electrode conductor group 12 and the second electrode conductor group 13.Then, the signals received by the first electrode conductor group 12 and the second electrode conductor group 13 are each supplied to the signal processing circuit 20.The signal processing circuit 20 is a circuit for executing predetermined signal processing on the signal received by the sensor 10.The signal processing circuit 20 includes selecting circuits 21 and 22, differential amplifier circuits 23 and 24, and a control circuit 25.The signals received by the sensor 10 are inputted in to the control circuit 25 via the selecting circuits 21 and 22 and the differential amplifier circuits 23 and 24 in the signal processing circuit 20.The control circuit 25 checks the level of the received signals at the respective electrode conductors 12Y1 to 12Ym of the first electrode conductor group 12 and the respective electrode conductors 13X1 to 13Xn of the second electrode conductor group 13, and detects that the indicating pen 40 exists over an electrode conductor where the level of the 1.8-MHz signal is a high level.", "Each of the first electrode conductors 12Y1 to 12Ym is connected to the selecting circuit 22 via the line-concentrated part 15.Similarly, each of the second electrode conductors 13X1 to 13Xn is connected to the selecting circuit 21 via the line-concentrated part 14.The selecting circuit 21 and the selecting circuit 22 are connected to the differential amplifier circuits 23 and 24, respectively.", "The selecting circuit 21 includes, for example, a microprocessor.", "The selecting circuit 21 selects an electrode conductor to be connected to the positive-side input terminal (non-inverting input terminal) of the differential amplifier circuit 23 and an electrode conductor to be connected to the negative-side input terminal (inverting input terminal) of the differential amplifier circuit 23 among the second electrode conductors 13X1 to 13Xn in response to selection control from the control circuit 25.Similarly, the selecting circuit 22 selects an electrode conductor to be connected to the positive-side input terminal of the differential amplifier circuit 24 and an electrode conductor to be connected to the negative-side input terminal of the differential amplifier circuit 24 among the first electrode conductors 12Y1 to 12Ym in response to selection control from the control circuit 25.The differential amplifier circuit 23 and the differential amplifier circuit 24 each perform a difference calculation between an input signal to the positive-side input terminal and an input signal to the negative-side input terminal.", "The differential amplifier circuit 23 and the differential amplifier circuit 24 then output, to the control circuit 25, output signals according to the intensity of signals received by the first electrode conductors 12Y1 to 12Ym and the second electrode conductors 13X1 to 13Xn, respectively, with noise entering the first electrode conductors 12Y1 to 12Ym and the second electrode conductors 13X1 to 13Xn being cancelled.", "In this embodiment, although not shown in FIG.", "1, the output signals of the differential amplifier circuit 23 and the differential amplifier circuit 24 are converted to a digital signal by an analog digital converter (ADC) to be supplied to the control circuit 25.The control circuit 25 detects the position coordinate of the X-axis direction of a position indicated by the indicating pen 40 on the sensor 10 from the intensity of the output signal of the differential amplifier circuit 23 and the second electrode conductors selected by the selecting circuit 21 among the second electrode conductors 13X1 to 13Xn.", "Furthermore, the control circuit 25 detects the position coordinate of the Y-axis direction of a position indicated by the indicating pen 40 on the sensor 10 from the intensity of the output signal of the differential amplifier circuit 24 and the first electrode conductors selected by the selecting circuit 22 among the first electrode conductors 12Y1 to 12Ym.", "In this manner, the control circuit 25 detects the coordinates of the position indicated by the indicating pen 40.A position indicated by the indicating pen 40 may be roughly detected by all of the electrode conductors of the sensor 10 such that, by the selecting circuit 21 and the selecting circuit 22, plural electrode conductors are connected to each of the positive-side input terminals and the negative-side input terminals of the differential amplifier circuit 23 and the differential amplifier circuit 24.In this embodiment, after the rough position of the indicating pen 40 is detected, detailed detection of the position indicated by the indicating pen 40 is carried out by plural first electrode conductors and second electrode conductors near the detected position.", "In the detailed detection of the indicated position, the selecting circuit 21 and the selecting circuit 22 are controlled by the control circuit 25 to select one each electrode conductor to be connected to the positive-side input terminals and the negative-side input terminals of the differential amplifier circuit 23 and the differential amplifier circuit 24.", "[Configuration Example of Sensor 10] Next, the configuration of the conductor patterns including the first electrode conductor group 12, the second electrode conductor group 13, and the line-concentrated parts 14 and 15 formed in the sensor 10 will be described with reference to FIGS.", "2 to 4.FIG.", "2 shows a detailed configuration example of the conductor patterns on the side of the front surface 11a of the substrate 11 of the sensor 10.FIG.", "3 shows a detailed configuration example of the conductor patterns on the side of the back surface 11b of the substrate 11 of the sensor 10.FIG.", "4 shows an enlarged view of part of the sensor 10 as viewed from the side of the front surface 11a of the substrate 11.As shown in FIG.", "2, on the front surface 11a of the substrate 11, plural conductor patterns (or conductor shapes) 31, each having, for example, a diamond shape or a square shape, are formed.", "The conductor patterns 31 are formed such that the direction of one of its two diagonals is parallel to the extension direction of the first electrode conductors 12Y1 to 12Ym (i.e., the X-axis direction).", "Similarly, the conductor patterns 31 are formed such that the direction of the other diagonal is parallel to the extension direction of the second electrode conductors 13X1 to 13Xn (i.e., the Y-axis direction).", "The conductor patterns 31 formed in this manner are closely arranged in the vertical direction, the horizontal direction, and oblique directions on the front surface 11a of the substrate 11.A slight gap g is formed between the conductor patterns 31 that are adjacent to each other.", "The gap g is formed between the conductor patterns 31 adjacent to each other in the oblique direction and has a distance d (see FIG.", "4) to ensure adjacent conductor patterns 31 are insulated from each other in the oblique direction.", "As shown in FIG.", "2, the plural conductor patterns 31 in each row lined along the X-axis direction are formed such that one of the diagonals thereof is disposed on one straight line along the X-axis direction.", "In addition, the conductor patterns 31 in each column lined along the Y-axis direction are formed such that the other of the diagonals thereof is disposed on one straight line along the Y-axis direction.", "By forming the plural conductor patterns 31 in this manner, plural rows of the plural conductor patterns 31, each lined on one straight line along the X-axis direction, are juxtaposed in the Y-axis direction on the front surface 11a of the substrate 11.As shown in FIG.", "2, first connecting parts 32Y (see FIG.", "4) are formed between respective two conductor patterns of the plural conductor patterns 31 and are lined in a straight line toward the left end in the X-axis direction from a conductor pattern formed at the right end among the plural conductor patterns 31, on each row lined on a straight line along the X-axis direction.", "The first connecting parts 32Y electrically connect the conductor patterns 31 adjacent in the X-axis direction to each other, and extend along the X-axis direction on the front surface 11a of the substrate 11.The conductor patterns 31 adjacent in the X-axis direction are electrically connected to each other by the first connecting parts 32Y to form the first electrode conductors 12Y1 to 12Ym shown in FIG.", "1.Hereinafter, the conductor patterns 31 configuring the first electrode conductors 12Y1 to 12Ym will be referred to as the conductor patterns 31Y.", "The conductor patterns 31Y and the first connecting parts 32Y are monolithically formed as printed patterns.", "For the plural conductor patterns 31 other than the plural conductor patterns 31Y configuring the first electrode conductors 12Y1 to 12Ym (hereinafter, referred to as the conductor patterns 31X), the conductor patterns 31X, which are in a straight line along the Y-axis direction, are electrically connected to each other, as described below, to form the second electrode conductors 13X1 to 13Xn.", "As shown in FIGS.", "3 and 4, plural through-holes 33X are formed in the substrate 11.The through-holes 33X are provided to overlap with the conductor patterns 31X and to electrically connect (via second connecting parts 34X to be described later) the conductor patterns 31X adjacent in the Y-axis direction to each other.", "One through-hole is made for each of the conductor patterns 31X disposed at both ends of the substrate 11 in the Y-axis direction and two through-holes are made for each of the other conductor patterns 31X.", "The through-holes 33X are arranged to form a line along the Y-axis direction.", "Plural such lines (or columns) of the plural through-holes 33X are juxtaposed in the X-axis direction.", "The side of the through-hole 33X on the front surface 11a is electrically connected to the conductor pattern 31X on which this through-hole 33X overlaps.", "Furthermore, as shown in FIGS.", "3 and 4, on the side of the back surface 11b of the substrate 11, plural second connecting parts 34X that electrically connect the conductor patterns 31X adjacent in the Y-axis direction to each other are provided.", "The second connecting parts 34X are formed to extend along the Y-axis direction and electrically connect two through-holes 33X that are close to each other among the through-holes 33X overlapping with two conductor patterns 31X adjacent to each other.", "In this manner, the conductor patterns 31X adjacent in the Y-axis direction are electrically connected to each other by the plural through-holes 33X and the plural second connecting parts 34X and form the second electrode conductors 13X1 to 13Xn extending along the Y-axis direction (see FIGS.", "2 and 3).", "Moreover, as shown in FIG.", "2, plural connecting lines 35X1 to 35Xn are formed on the front surface 11a of the substrate 11.One end of each of the plural connecting lines 35X1 to 35Xn is electrically connected to the conductor pattern 31X formed at the lower end in the Y-axis direction among the conductor patterns 31X configuring a corresponding one of the second electrode conductors 13X1 to 13Xn, and the other end is formed to be led to the line-concentrated part 14 formed at the projecting part 14A of the substrate 11.The plural connecting lines 35X1 to 35Xn are formed in an interconnect area 36 provided on the lower end side of the substrate 11 in the Y-axis direction and are formed to be routed along the periphery of the substrate 11 and led to the line-concentrated part 14.On the other hand, as described below in reference to FIG.", "3, connecting lines 38Y1 to 38Ym for the first electrode conductors 12Y1 to 12Ym are densely formed on the side of the back surface 11b of the substrate 11 by being disposed in parallel and close to each other in an area opposed to the conductor patterns 31 (31Y and 31X) closely arranged on the front surface 11a of the substrate 11.Specifically, as shown in FIGS.", "3 and 4, through-holes 37Y are formed in the substrate 11 in such a manner that each through-hole 37Y overlaps with one conductor pattern 31Y among the plural conductor patterns 31Y configuring a respective one of the first electrode conductors 12Y1 to 12Ym.", "The through-holes 37Y connect the connecting lines 38Y1 to 38Ym to the corresponding first electrode conductors 12Y1 to 12Ym, respectively.", "The side of the through-hole 37Y on the front surface 11a of the substrate 11 is electrically connected to the conductor pattern 31Y on which this through-hole 37Y overlaps.", "Furthermore, one end of each of the connecting lines 38Y1 to 38Ym is electrically connected to the through-hole 37Y formed for the conductor pattern 31Y configuring a corresponding one of the first electrode conductors 12Y1 to 12Ym.", "Because the second connecting parts 34X of the second electrode conductors 13X1 to 13Xn are provided on the back surface 11b of the substrate 11, the through-holes 37Y overlapping with the conductor patterns 31Y adjacent in the Y-axis direction are slightly offset from the second connecting parts 34X and from each other in the X-axis direction.", "The purpose of this is to shorten the lengths of the connecting lines 38Y1 to 38Ym while preventing them from overlapping with the second connecting parts 34X.", "As shown in FIG.", "3, one end of each of the connecting lines 38Y1 to 38Ym is electrically connected via the through-hole 37Y to the conductor pattern 31Y configuring a corresponding one of the first electrode conductors 12Y1 to 12Ym.", "Each of the connecting lines 38Y1 to 38Ym is formed to linearly extend along the Y-axis direction at least in the area opposed to the conductor patterns 31.The other end of each of the connecting lines 38Y1 to 38Ym is formed to be led to the line-concentrated part 15 of the projecting part 15A provided at the lower end of the substrate 11 in the Y-axis direction.", "By setting the extension direction of the second connecting parts 34X parallel to the extension direction of the connecting lines 38Y1 to 38Ym in this manner, the connecting lines 38Y1 to 38Ym can be formed close to the second connecting parts 34X.", "Therefore, the distance between two electrode conductors connected to the non-inverting input terminal and the inverting input terminal of the differential amplifier circuit 23 can be shortened and enhancement in the noise resistance obtained by the differential amplification can be achieved.", "Moreover, because the distances among the connecting lines 38Y1 to 38m can be set shorter, the lowering of the density of the connecting lines 38Y1 to 38m can be minimized.", "The connecting lines 35X1 to 35Xn for the second electrode conductors 13X1 to 13Xn are formed in the interconnect area 36 on the side of the front surface 11a of the substrate 11.Therefore, according to this embodiment, the interconnect area of the connecting lines can be smaller than in the related arts.", "Thus, the size of the substrate can be reduced, which can prevent the lowering of convenience and design property.", "Furthermore, because the connecting lines 35X1 to 35Xn for the second electrode conductors 13X1 to 13Xn are formed in the interconnect area, a detection result of a position indicated by the indicating pen can be obtained with the same accuracy as that in the related arts regarding received signals from the second electrode conductors 13X1 to 13Xn.", "The connecting lines 38Y1 to 38Ym for the first electrode conductors 12Y1 to 12Ym are formed on the side of the back surface 11b of the substrate 11 to overlap with the conductor patterns 31 (31X and 31Y), which form the first electrode conductor group 12 and the second electrode conductor group 13 on the side of the front surface 11a of the substrate 11.Therefore, the influence of a jump of a transmitted signal from the indicating pen 40 to the connecting lines 38Y1 to 38m is an issue.", "However, the connecting lines 38Y1 to 38m are electrostatically shielded by the plural conductor patterns 31 (31X and 31Y) provided on the front surface 11a of the substrate 11, and reception of a transmitted signal from the indicating pen 40 by the connecting lines 38Y1 to 38m is prevented or alleviated.", "Furthermore, the connecting lines 38Y1 to 38m are disposed close to each other.", "Therefore, even when a signal or noise is superimposed on these connecting lines 38Y1 to 38Ym, the signal or noise is superimposed on connecting lines adjacent to each other in a similar manner.", "This allows the signal or noise superimposed on the connecting lines 38Y1 to 38Ym to be removed by performing a difference calculation on signals from plural electrode conductors in the differential amplifier circuit of the signal processing circuit.", "Furthermore, the connecting lines 38Y1 to 38Ym for the first electrode conductors 12Y1 to 12Ym are formed on the side of the back surface 11b of the substrate 11 and extend along the Y-axis direction intersecting (orthogonal to) the X-axis direction, along which the first electrode conductors 12Y1 to 12Ym extend.", "Thus, it is easy to form the connecting lines 38Y1 to 38Ym in parallel and close to each other on the side of the back surface 11b of the substrate 11.Moreover, for the second electrode conductors 13X1 to 13Xn, whose extension direction is the direction along which the connecting lines 38Y1 to 38Ym extend, the conductor patterns 31X are connected to each other by the second connecting parts 34X along the Y-axis direction via through-holes on the side of the back surface 11b of the substrate 11.Thus, the connecting lines 38Y1 to 38Ym are parallel to the second connecting parts 34X.", "Therefore, even when the connecting lines 38Y1 to 38Ym straddle the second connecting parts 34X, the distance between the connecting lines 38Y1 to 38Ym straddling the second connecting parts 34X can be short and the lowering of the density of the connecting lines 38Y1 to 38Ym can be suppressed to a minimum.", "Second Embodiment A second embodiment is a modification example of the first embodiment.", "A sensor 10B in the second embodiment is different from the sensor 10 in the first embodiment in the following points.", "Specifically, the respective conductor patterns 31X configuring the second electrode conductors 13X1 to 13Xn formed on the front surface 11a of the substrate 11 of the sensor 10B of the second embodiment are connected to each other on the front surface Ila of the substrate 11.Furthermore, the respective conductor patterns 31Y configuring the first electrode conductors 12Y1 to 12Ym are connected to each other on the side of the back surface 11b of the substrate 11.FIG.", "5 is a diagram for explaining a configuration example of the major part of the sensor 10B of a position detecting device of the second embodiment.", "In FIG.", "5, the same part as that in the first embodiment is given the same reference symbol.", "This FIG.", "5 corresponds to FIG.", "4 for the above-described first embodiment and shows an enlarged view of part of the sensor 10B as viewed from the side of the front surface 11a of the substrate 11 of the sensor 10B.", "FIG.", "6 shows the positions of projecting parts 14B and 15B for line-concentrated parts provided in the substrate 11 of the sensor 10B in the case of the second embodiment.", "In the second embodiment, third connecting parts 32X, which electrically connect the adjacent conductor patterns 31 to each other, are formed between respective two of the plural conductor patterns 31 that are lined on a straight line.", "Multiple such lines are formed and arranged from the upper end toward the lower end in the Y-axis direction, as viewed from the side of the front surface 11a of the substrate 11, among the plural conductor patterns 31 on each column lined on a straight line along the Y-axis direction.", "The third connecting parts 32X are formed to extend along the Y-axis direction on the front surface 11a of the substrate 11.The conductor patterns 31X adjacent in the Y-axis direction are electrically connected to each other by the third connecting parts 32X, so that the second electrode conductors 13X, to 13Xn shown in FIG.", "1 (in FIG.", "5, 13Xj, 13Xj+1, and 13Xj+2 are shown) are each formed.", "The conductor patterns 31X and the third connecting parts 32X are monolithically formed as printed patterns.", "The plural conductor patterns 31Y, other than the plural conductor patterns 31X configuring the second electrode conductors 13X1 to 13Xn, included in a straight line along the X-axis direction are electrically connected to each other as described below to form each of the first electrode conductors 12Y1 to 12Ym (in FIGS.", "5, 12Yi, 12Yi+1, and 12Yi+2).", "Specifically, as shown in FIG.", "5, through-holes 33Y are formed in the substrate 11.The through-holes 33Y overlap with the plural conductor patterns 31Y and electrically connect the conductor patterns 31Y adjacent in the X-axis direction to each other (via fourth connecting parts 34Y to be described later).", "In regards to the through-holes 33Y, as shown in FIG.", "5, one through-hole is made for each of the conductor patterns 31Y that are disposed at both ends of the substrate 11 in the X-axis direction and two through-holes are made for each of the other conductor patterns 31Y.", "The through-holes 33Y are formed to make a line along the X-axis direction, and plural rows of the plural through-holes 33Y, each arranged on a line, are juxtaposed in the Y-axis direction.", "The side of the through-hole 33Y on the front surface 11a of the substrate 11 is electrically connected to the conductor pattern 31Y, on which this through-hole 33Y overlaps.", "As shown in FIG.", "5, on the back surface of the substrate 11, fourth connecting parts 34Y for electrically connecting the conductor patterns 31Y adjacent in the X-axis direction to each other are formed.", "The fourth connecting part 34Y is formed to extend along the X-axis direction and electrically connect two through-holes 33Y close to each other among the through-holes 33Y overlapping with two conductor patterns 31Y adjacent to each other.", "The conductor patterns 31Y adjacent in the X-axis direction are electrically connected to each other by the plural through-holes 33Y and the plural fourth connecting parts 34Y to form the first electrode conductors 12Y1 to 12Ym extending along the X-axis direction (see 12Yi, 12Yi+1, and 12Yi+2 in FIG.", "5).", "As shown in FIG.", "6, on the left end side of the substrate 11, as viewed from the front surface side, the projecting parts 14B and 15B for line-concentrated parts 14′ and 15′ are formed similar to the first embodiment.", "Although not shown in FIG.", "6, on the front surface of the substrate 11, plural connecting lines are formed to be led from the conductor patterns 31Y at the left end among the conductor patterns 31Y configuring the first electrode conductors 12Y1 to 12Ym to the line-concentrated part 14′ formed at the projecting part 14B of the substrate 11.These plural connecting lines are formed in an interconnect area 36B provided on the front surface of the substrate 11 and on the left end side in the X-axis direction.", "On the other hand, as shown in FIG.", "5, connecting lines 38X for the second electrode conductors 13X1 to 13Xn are densely formed on the back surface side of the substrate 11 by being disposed in parallel and close to each other in an area opposed to the conductor patterns 31 (31Y and 31X) closely arranged on the front surface 11a of the substrate 11, similar to the first embodiment.", "Specifically, as shown in FIG.", "5, through-holes 37X for connecting the plural connecting lines 38X to the corresponding second electrode conductors 13X1 to 13Xn are formed in the substrate 11 such that each through-hole 37X overlaps with one conductor pattern 31X among the plural conductor patterns 31X configuring a respective one of the second electrode conductors 13X1 to 13Xn.", "The side of the through-hole 37X on the front surface side of the substrate 11 is electrically connected to the conductor pattern 31X on which the through-hole 37X overlaps.", "One end of each of the plural connecting lines 38X corresponding to the second electrode conductors 13X1 to 13Xn is electrically connected to the through-hole 37X formed for the conductor pattern 31X configuring a corresponding one of the second electrode conductors 13X1 to 13Xn.", "Furthermore, as shown in FIG.", "5, each of the connecting lines 38X is formed to linearly extend along the X-axis direction on the back surface side of the substrate 11.The other ends of the connecting lines 38X are formed to be each led to the line-concentrated part 15′ of the projecting part 15B provided at the left end of the substrate 11 in the X-axis direction.", "The through-holes 37X of the conductor patterns 31X are formed such that the parts linearly extending along the X-axis direction for the plural connecting lines 38X are disposed in parallel and close to each other.", "Also in the second embodiment, because the fourth connecting parts 34Y are provided on the back surface of the substrate 11, the through-holes 37X overlapping with the conductor patterns 31X adjacent in the X-axis direction are slightly offset from the fourth connection parts 34Y and from each other in the Y-axis direction.", "The purpose of this is to shorten the lengths of the connecting lines 38X while preventing them from overlapping with the fourth connecting parts 34Y.", "One end of each of the connecting lines 38X is electrically connected to a corresponding one of the second electrode conductors 13X1 to 13Xn via the through-hole 37X.", "Each connecting line 38X is formed to linearly extend along the X-axis direction at least in the area opposed to the conductor patterns 31.The other end of each of the connecting lines 38X is formed to be led to the line-concentrated part 15′ of the projecting part 15B provided at the left end of the substrate 11 in the X-axis direction.", "In this case, whereas the extension direction of the second electrode conductors 13X1 to 13Xn is the Y-axis direction, the extension direction of each of the plural connecting lines 38X is the X-axis direction.", "This allows the parts linearly extending along the X-axis direction in the connecting lines 38X to be disposed in parallel and close to each other.", "As above, in the second embodiment, the connecting lines 38X can be formed close to the fourth connecting parts 34Y because the extension direction of the fourth connecting parts 34Y is parallel to the extension direction of the connecting lines 38X.", "Therefore, the distance between two electrode conductors connected to the non-inverting input terminal and the inverting input terminal of the differential amplifier circuit 23 can be shortened and enhancement in the noise resistance obtained by the differential amplification can be achieved.", "Moreover, because the distances among the connecting lines 38X can be set shorter, the lowering of the density of the connecting lines 38X can be minimized.", "Furthermore, in the second embodiment, only the connecting of the conductor patterns 31 (31Y and 31X) regarding the first electrode conductors 12Y1 to 12Ym and the second electrode conductors 13X1 to 13Xn, and the lead-out direction of the connecting lines are different from the first embodiment as described above.", "The same operation and effect as those of the above-described first embodiment are achieved.", "Third Embodiment In the above-described first and second embodiments, the cases in which the connecting lines of either one of the first electrode conductors 12Y1 to 12Ym and the second electrode conductors 13X1 to 13Xn are formed on the back surface of the substrate 11 are exemplified.", "However, the connecting lines of both the first electrode conductors 12Y1 to 12Ym and the second electrode conductors 13X1 to 13Xn may be formed on the back surface of the substrate 11 and be made opposed to the conductor patterns 31 (31Y and 31X) configuring the first electrode conductors 12Y1 to 12Ym and the second electrode conductors 13X1 to 13Xn.", "A third embodiment is an example of this case.", "FIGS.", "7A and 7B are diagrams for explaining an outline of a sensor 10D of the third embodiment.", "As shown in FIG.", "7A, the sensor 10D in the third embodiment includes a first substrate 11D and a second substrate 11E, and has a structure obtained by attaching the first substrate 11D and the second substrate 11E to each other.", "In the first substrate 11D, instead of the through-holes 37X in the second embodiment, vias 37XD that penetrate both the first and second substrates 11D and 11E when the first and second substrates 11D and 11E are attached to each other are formed.", "Furthermore, in the first substrate 11D, similar to the through-holes 33Y in the second embodiment, vias 33YB for electrically connecting the conductor patterns 31Y adjacent in the X-axis direction to each other (via the fourth connecting parts 34Y) on a back surface 11Db of the first substrate 11D are formed.", "The vias 37XD and the vias 33YB are formed at the same positions where the through-holes 37X and 33Y in the second embodiment are formed.", "As shown in FIG.", "7B, plural third connecting parts 32X extended along the Y-axis direction are provided on a front surface 11Da of the first substrate 11D.", "The conductor patterns 31X adjacent in the Y-axis direction are connected to each other by the third connecting parts 32X to form each of the second electrode conductors 13X1 to 13Xn (in FIG.", "7B, 13Xj, 13Xj+1, and 13Xj+2 are shown).", "Furthermore, plural fourth connecting parts 34Y extended along the X-axis direction are formed on the back surface 11Db of the first substrate 11D.", "The fourth connecting part 34Y is formed between the conductor patterns 31Y adjacent in the X-axis direction.", "Both ends of the fourth connecting part 34Y are electrically connected to the vias 33YB each formed for a respective one of the conductor patterns 31Y adjacent in the X-axis direction.", "In this manner, the conductor patterns 31Y formed adjacent in the X-axis direction are electrically connected through the vias 33YB and the fourth connecting parts 34Y to form each of the first electrode conductors 12Y1 to 12Ym (see 12Yi, 12Yi+1, and 12Yi+2 in FIG.", "7B).", "In the second substrate 11E, the vias 37XD and plural connecting lines 38XD (on a back surface 11Eb of the second substrate 11E, as described later) and 38YD (on a front surface 11Ea of the second substrate 11E, as described later) are formed.", "As shown in FIG.", "7A, a front surface 11Ea of this second substrate 11E is attached to the back surface 11Db of the first substrate 11D.", "The fourth connecting parts 34Y are provided between the front surface 11Ea of the second substrate 11E and the back surface 11Db of the first substrate 11D.", "As shown in FIG.", "7B, one end of each of the plural connecting lines 38XD is connected to a respective one of the conductor patterns 31X arranged in the X-axis direction among the conductor patterns 31X configuring the second electrode conductors 13X1 to 13Xn by the vias 37XD made between the front surface 11Da of the first substrate 11D and the back surface 11Eb of the second substrate 11E.", "As shown in FIG.", "7B, the plural connecting lines 38XD extend along the X-axis direction and are densely formed in parallel and close to each other.", "The plural connecting lines 38XD are provided on the back surface 11Eb of the second substrate 11E.", "Thus, the density thereof can be set high because other conductor lines that should be avoided do not exist.", "Furthermore, as shown in FIG.", "7B, one end of each of the plural connecting lines 38YD is connected to a respective one of the conductor patterns 31Y arranged in the Y-axis direction among the conductor patterns 31Y configuring the first electrode conductors 12Y1 to 12Ymby vias 37YD penetrating the first substrate 11D.", "The connecting lines 38YD extend between the back surface 11Db of the first substrate 11D and the front surface 11Ea of the second substrate 11E.", "In this case, the plural connecting lines 38YD extend along the X-axis direction in parallel with each other as shown in FIG.", "7B.", "The plural connecting lines 38YD are provided on the back surface 11Db of the first substrate 11D.", "[Modification Examples of Shape of Conductor Pattern 31] FIRST EXAMPLE In the above-described embodiments, the cases in which the conductor patterns 31 (31X and 31Y) are formed into a diamond shape, particularly a square shape, are exemplified.", "However, the shape of the conductor patterns 31 (31X and 31Y) may be any shape as long as the first electrode conductors 12Y1 to 12Ym are the same as the second electrode conductors 13X1 to 13Xn in the detection sensitivity of the indicator and the shape allows the whole of the front surface 11a of the substrate 11 to be covered as much as possible.", "FIGS.", "8A to 8D are diagrams showing a first example of another shape of the conductor pattern 31.In the first example, only the shape of the sensor is different from the sensor 10 in the above-described first embodiment.", "Specifically, as shown in FIG.", "8A, a conductor pattern 311 of the first example is obtained by transforming the conductor pattern 31 having the square shape in the above-described embodiments into a shape having four protruding parts 311a, 311b, 311c, and 311d.", "The other configurations are the same as that of the first embodiment and therefore detailed description thereof is omitted.", "The first electrode conductors 12Y1 to 12Ym (12Yi, 12Yi+1, and 12Yi+2 are shown in FIG.", "8B) and the second electrode conductors 13X1 to 13Xn (13Xj, 13Xj+1, and 13Xj+2 are shown in FIG.", "8B) in the first example are composed of plural conductor patterns 311Y (see FIG.", "8D) and conductor patterns 311X (see FIG.", "8C), respectively.", "Furthermore, as shown in FIG.", "8B, the conductor patterns 311Y configuring each of the first electrode conductors 12Y1 to 12Ym arranged along the X-axis direction and the conductor patterns 311X configuring each of the second electrode conductors 13X1 to 13Xn arranged along the Y-axis direction are configured to partially enter each other's conductor pattern areas and are interlaced with each other by using each other's protruding parts 311a, 311b, 311c, and 311d.", "In the case of the conductor patterns 311 (311Y and 311X) shown in the first example, the adjacent conductor patterns 311 (311Y and 311X) partially enter each other's conductor pattern areas and are interlaced with each other as shown in FIG.", "8B.", "Therefore, the second highest signal level increases at the electrode conductor that receives a signal from an indicating pen, which can enhance the detection sensitivity of the indicating pen.", "Accordingly, as shown in FIG.", "8B, forming pitches Py and Px of the first electrode conductors 12Y1 to 12Ym and the second electrode conductors 13X1 to 13Xn, respectively, can be set larger than related arts, so that the number of multiplexers to switch the first electrode conductors 12Y1 to 12Ym and the second electrode conductors 13X1 to 13Xn can be reduced.", "SECOND EXAMPLE FIGS.", "9A to 9D show a second example of a modification of the conductor pattern 31.The second example is an example of the conductor pattern obtained by transforming the conductor pattern of the first example.", "The same part as that in the first example is given the same symbol.", "As shown in FIG.", "9A, in a conductor pattern 312 of the second example, a square part 312e that is electrically non-connected (in a floating state) is formed at the center part having the protruding parts 311a, 311b, 311c, and 311d.", "The other configurations are the same as that of the conductor pattern 311 shown in the first example.", "The first electrode conductors 12Y1 to 12Ym (12Yi, 12Yi+1, and 12Yi+2 are shown in FIG.", "9B) and the second electrode conductors 13X1 to 13Xn (13Xj, 13Xj+1, and 13Xj+2 are shown in FIG.", "9B) in the second example are composed of plural conductor patterns 312Y (see FIG.", "9D) and conductor patterns 312X (see FIG.", "9C), respectively.", "Furthermore, similar to the first electrode conductors 12Y1 to 12Ym and the second electrode conductors 13X1 to 13Xn in the first example, the conductor patterns 312Y configuring each of the first electrode conductors 12Y1 to 12Ym arranged along the X-axis direction and the conductor patterns 312X configuring each of the second electrode conductors 13X1 to 13Xn arranged along the Y-axis direction are configured to partially enter each other's conductor pattern areas and are interlaced with each other by using each other's protruding parts 311a, 311b, 311c, and 311d.", "According to the second example, the square part 312e formed in the electrically floating state does not contribute to reception of a transmitted signal from an indicating pen.", "Therefore, the second highest signal level further increases at the electrode conductor that receives a signal from the indicating pen 40 (see FIG.", "1), which can further enhance the detection sensitivity.", "THIRD EXAMPLE FIGS.", "10A to 10D show a third example of a modification of the conductor pattern 31.The third example is an example of the conductor pattern obtained by transforming the conductor pattern of the second example.", "The same part as that in the second example is given the same symbol.", "As shown in FIG.", "10A, in a conductor pattern 313 of the third example, an area 313f in which the conductor pattern does not exist is formed at the part corresponding to the square part 312e in the conductor pattern 312 of the second example.", "Furthermore, beside the protruding part 311a of the conductor pattern 313, a square part 313g corresponding to the area 313f is formed to protrude toward the adjacent conductor pattern 313.The square part 313g is formed in the area 313f formed in the adjacent conductor pattern 313 in an electrically floating state with respect to the adjacent conductor pattern 313.The other configurations are the same as that of the second example.", "According to the third example, because the square part 313g is formed to enter the adjacent conductor pattern 313, the detection sensitivity of the indicating pen can be enhanced similar to the conductor patterns 311 and 312 in the first and second examples, respectively.", "Other Embodiments or Modification Examples The above embodiments are described by exemplifying the cases of application thereof to a sensor of a system to detect a position indicated by the indicating pen 40 based on change in the capacitance at the intersections of the first electrode conductors extending along the X-axis direction and the second electrode conductors extending along the Y-axis direction.", "However, it is also possible to apply the invention to a sensor in which electrode conductors are arranged along only one of the X-axis direction and the Y-axis direction.", "By forming the conductor patterns to configure the first electrode conductors and the second electrode conductors by a transparent electrode conductor, such as indium tin oxide (ITO), the sensor of the position detecting device of the invention can be superimposed on a display device such as a liquid crystal display.", "It is obvious that the conductor patterns to configure the first electrode conductors and the second electrode conductors do not need to be formed by a transparent conductor if the sensor is not superimposed on a display device, such as a liquid crystal display.", "It is to be noted that the embodiment of the present disclosure is not limited to the foregoing embodiments, and that various changes can be made without departing from the spirit of the present disclosure." ] ]
Patent_15872632
[ [ "SYSTEMS AND APPARATUS FOR GAIT MODULATION AND METHODS OF USE", "An apparatus includes a frame, a sensor, and an electric stimulator.", "The frame is removably couplable to a portion of a limb.", "The sensor is configured to produce a first signal associated with a gait characteristic at a first time, and a second signal associated with the gait characteristic at a second time, after the first time.", "The electric stimulator is removably coupled to the frame and is in electrical communication with an electrode assembly and the sensor to receive the first signal substantially at the first time and the second signal substantially at the second time.", "Based in part on the gait characteristic at the first time, the electric stimulator sends a third signal to the electrode assembly to provide an electric stimulation to a portion of a neuromuscular system of the limb substantially during a time period defined between the first time and the second time." ], [ "1.A method, comprising: receiving, at an electric stimulator and from a sensor, the sensor being one of a tilt sensor, an accelerometer, or a gyroscope, a first signal associated with a gait characteristic; calculating one or more system parameters based at least in part on the first signal associated with the gait characteristic; sending a signal, based at least in part on the one or more system parameters, from the electric stimulator to an electrode assembly to cause the electrode assembly to provide an electric stimulation to a portion of a neuromuscular system of a limb; receiving, at the electric stimulator and from the sensor, a second signal associated with the gait characteristic; and terminating the electric stimulation of the portion of the neuromuscular system of the limb based on the receiving of the second signal associated with the gait characteristic.", "2.The method of claim 1, wherein the sensor is at least partially integrated with the electric stimulator.", "3.The method of claim 1, wherein the electric stimulator is in wireless electrical communication with a control device, the calculating one or more system parameters includes calculating one or more system parameters defined by the control device.", "4.The method of claim 1, wherein the receiving of the first signal associated with the gait characteristic is via a wireless communication mode; and the receiving of the second signal associated with the gait characteristic is via the wireless communication mode.", "5.The method of claim 1, wherein the sending the signal from the electric stimulator to the electrode assembly to cause the electrode assembly to provide an electric stimulation to a portion of a neuromuscular system of a limb is associated with a heel-off event during ambulatory motion of the limb; and the terminating the electric stimulation of the portion of a neuromuscular system of the limb is associated with a heel-on event during the ambulatory motion of the limb.", "6.The method of claim 1, wherein the receiving the first signal associated with the gait characteristic is at a first time; the receiving the second signal associated with the gait characteristic is at a second time, after the first time; and the sending the signal to the electrode assembly to cause the electrode assembly to provide the electric stimulation to the portion of the neuromuscular system of the limb includes providing the electric stimulation during a time period defined between the first time and the second time.", "7.A method of using an electric stimulator having a sensor and an electrode assembly in electrical communication with a portion of a neuromuscular system of a limb, the method comprising: receiving, at the electric stimulator, a first signal, the first signal sent from a control device via a first communication channel, the first communication channel associated with a wireless communication over a network, the first signal associated with a system parameter; sending, from the electric stimulator and via the first communication channel, a second signal, the second signal sent to the control device and being associated with a confirmation of the system parameter; receiving, at the electric stimulator a third signal, the third signal sent from the sensor via a second communication channel different from the first communication channel, the third signal associated with a gait characteristic; and sending, from the electric stimulator and to the electrode assembly, a fourth signal, the fourth signal operable to cause the electrode assembly to provide an electric stimulation to the portion of the neuromuscular system of the limb based at least in part on the system parameter and the gait characteristic.", "8.The method of claim 7, wherein the control device is at least one of a personal computer, laptop, tablet, smart phone, personal digital assistant, or console.", "9.The method of claim 7, further comprising: receiving, at the electric stimulator, a fifth signal, the fifth signal sent from the sensor via the second communication channel and being associated with the gait characteristic; and terminating the electric stimulation of the portion of the neuromuscular system of the limb based at least in part on the receiving, at the electric stimulator, the fifth signal.", "10.The method of claim 7, wherein the gait characteristic is a first gait characteristic and the sensor is a first sensor, the first sensor at least partially integrated with the electric stimulator, the method further comprising: receiving, at the electric stimulator a fifth signal, the fifth signal sent from a second sensor via a third communication channel, different from the first communication channel and the second communication channel, the second sensor being physically distinct from the electric stimulator, the third communication channel associated with a wireless communication mode, the fifth signal associated with a second gait characteristic; and the sending the fourth signal to the electrode assembly to cause the electrode assembly to provide an electric stimulation to the portion of the neuromuscular system of the limb is based at least in part on the system parameter and the first gait characteristic and the second gait characteristic.", "11.The method of claim 7, wherein the electric stimulator is a first electric stimulator and the portion of the neuromuscular system of the limb is a first portion of the neuromuscular system of the limb, the method further comprising: sending, from the first electric stimulator, a fifth signal via a third communication channel, different from the first communication channel and the second communication channel, the fifth signal being sent to a second electric stimulator including an electrode assembly in electrical communication with a second portion of the neuromuscular system of the limb, the fifth signal operable to cause the electrode assembly of the second electric stimulator to provide an electric stimulation to the second portion of the neuromuscular system of the limb based at least in part on the system parameter and the gait characteristic." ], [ "<SOH> BACKGROUND <EOH>The embodiments described herein relate generally to gait modulation systems, and more particularly, to a functional electrical stimulation (FES) orthosis for gait modulation and methods of using the same.", "It is known that pathologies of the neuromuscular system due to disease or trauma to the central nervous system, such as for example, stroke, spinal cord injury, head injury, cerebral palsy, and multiple sclerosis can impede limb function of the arms or legs (or portions thereof).", "Gait, the biomechanical description of walking, can suffer static and dynamic parameter variations due to neuromuscular impairments, which cause non-symmetrical walking, reduced walking speed, and reduced walking stability.", "For example, drop foot describes a gait attributable to weak or uncoordinated activation of the ankle dorsiflexors due to disease or trauma to the central nervous system.", "Patients suffering from drop foot tend to drag the foot during the swing phase of walking and usually try to compensate for this dragging by hiking the corresponding hip or swinging the corresponding leg in a circular motion.", "These patients tend to have reduced stability, are prone to frequent falls, and their walking movements are unaesthetic and energy consuming.", "Limb muscles, however, can generally be activated with functional electrical stimulation (FES).", "In FES, precisely timed bursts of short electrical pulses (e.g., from a neuroprosthetic, an FES orthosis, and/or the like) are applied to motor nerves to generate muscle contraction, which can be applied to enhancing limb function.", "Although neuroprosthetic systems are known, some such systems suffer from drawbacks that prevent the systems from being widely used by potential patients.", "For example, in instances in which stroke or brain injury results in problems with arm movement or gait, such problems are often accompanied by hand impairment on the same side of the body as the problematic limb.", "Thus, donning an FES orthosis is often carried out using solely the contra-lateral, unaffected hand.", "Moreover, the posture of the plegic limb is often problematic, especially in cases where spasticity results in reduced voluntary movements and/or limited passive range of motion of the limb joints.", "Consequently, objective biomechanical problems exist in donning some known orthotic devices as well as locating the electrodes in exact positions onto the limb, which is essential for activating the desired movement pattern.", "As such, some known neuroprosthetic devices fail to enable facile, quick, and accurate donning of the device by an impaired patient using a single hand, and particularly, when the least effected hand is shaky or otherwise unstable.", "FES devices typically utilize a stimulator unit to create and control the electrical pulses being applied to motor nerves that is physically separate from the FES orthosis.", "The external stimulator unit, which is connected to the FES orthosis by several electrical wires, is located on the body of the user and/or is otherwise worn by the user.", "These devices can be inconvenient for the user.", "Specifically, the wiring, which is usually arranged to run along the leg under the clothing to connect the device components, can be difficult to operate, cumbersome and uncomfortable.", "In other instances, an FES orthosis can be a self-contained device.", "For example, some known orthoses can include a stimulator unit coupled to a narrow band that is made of a thermoplastic material, which is molded to the limb anatomy of an individual user by heating and softening the thermoplastic material and subsequently fitting the band to the contour of the underlying limb segment.", "Thus, the shape and size of the device and the electrode positioning is custom-fitted to the leg of one user and individualized for the user.", "This procedure is carried out by a medical professional trained, for example, to accurately identify the stimulation points that cause contraction of the muscles, positioning and locking the electrodes thereto.", "Activation of the leg muscles by electrical stimulation typically includes transferring high stimulation currents through one or more electrodes to the skin surface of the patient, which activates skin sensory receptors in addition to underlying excitable motor nerve and muscle tissue.", "As a result, the intensity of sensory activation often depends on the intensity of the current density passing through the skin surface.", "The level of muscle activation, therefore, is often limited to the patient's individual tolerance to activation of such skin pain sensors.", "Thus, the stimulation parameters of the device are adjusted for each patient, which can be time consuming and often includes attaching the orthosis to a control device via wires.", "Therefore, a need exists for improved systems and apparatus for a neuroprosthetic system that can be easily and accurately donned on the limb by patient and that includes a stimulation unit that can be remotely controlled and/or adjusted." ], [ "<SOH> SUMMARY <EOH>Systems and apparatus for gait modulation and methods of use are described herein.", "In some embodiments, an apparatus includes a frame assembly, a sensor, and an electric stimulator.", "The frame is configured to be removably coupled to a portion of a limb such that the portion of the limb is substantially enveloped by the frame.", "The sensor is operably coupled to the frame and is configured to produce a first signal associated with a gait characteristic at a first time, and a second signal associated with the gait characteristic at a second time, after the first time.", "The first time and the second time define a time period therebetween.", "The electric stimulator is removably coupled to the frame and is in electrical communication with the sensor and an electrode assembly.", "The electrode assembly is in electrical communication with a portion of a neuromuscular system of the limb when the frame is coupled thereto and is configured to receive the first signal from the sensor substantially at the first time and the second signal from the sensor substantially at the second time.", "Based at least in part on the gait characteristic at the first time, the electric stimulator is configured to send a third signal to the electrode assembly substantially at the first time operable to cause the electrode assembly to provide an electric stimulation to the portion of the neuromuscular system of the limb substantially during the time period." ], [ "CROSS-REFERENCE TO RELATED PATENT APPLICATION This application is a continuation of U.S. patent application Ser.", "No.", "14/223,340, filed on Mar.", "24, 2014, entitled “Systems and Apparatus for Gait Modulation and Methods of Use,” the disclosure of which is incorporated herein by reference in its entirety.", "BACKGROUND The embodiments described herein relate generally to gait modulation systems, and more particularly, to a functional electrical stimulation (FES) orthosis for gait modulation and methods of using the same.", "It is known that pathologies of the neuromuscular system due to disease or trauma to the central nervous system, such as for example, stroke, spinal cord injury, head injury, cerebral palsy, and multiple sclerosis can impede limb function of the arms or legs (or portions thereof).", "Gait, the biomechanical description of walking, can suffer static and dynamic parameter variations due to neuromuscular impairments, which cause non-symmetrical walking, reduced walking speed, and reduced walking stability.", "For example, drop foot describes a gait attributable to weak or uncoordinated activation of the ankle dorsiflexors due to disease or trauma to the central nervous system.", "Patients suffering from drop foot tend to drag the foot during the swing phase of walking and usually try to compensate for this dragging by hiking the corresponding hip or swinging the corresponding leg in a circular motion.", "These patients tend to have reduced stability, are prone to frequent falls, and their walking movements are unaesthetic and energy consuming.", "Limb muscles, however, can generally be activated with functional electrical stimulation (FES).", "In FES, precisely timed bursts of short electrical pulses (e.g., from a neuroprosthetic, an FES orthosis, and/or the like) are applied to motor nerves to generate muscle contraction, which can be applied to enhancing limb function.", "Although neuroprosthetic systems are known, some such systems suffer from drawbacks that prevent the systems from being widely used by potential patients.", "For example, in instances in which stroke or brain injury results in problems with arm movement or gait, such problems are often accompanied by hand impairment on the same side of the body as the problematic limb.", "Thus, donning an FES orthosis is often carried out using solely the contra-lateral, unaffected hand.", "Moreover, the posture of the plegic limb is often problematic, especially in cases where spasticity results in reduced voluntary movements and/or limited passive range of motion of the limb joints.", "Consequently, objective biomechanical problems exist in donning some known orthotic devices as well as locating the electrodes in exact positions onto the limb, which is essential for activating the desired movement pattern.", "As such, some known neuroprosthetic devices fail to enable facile, quick, and accurate donning of the device by an impaired patient using a single hand, and particularly, when the least effected hand is shaky or otherwise unstable.", "FES devices typically utilize a stimulator unit to create and control the electrical pulses being applied to motor nerves that is physically separate from the FES orthosis.", "The external stimulator unit, which is connected to the FES orthosis by several electrical wires, is located on the body of the user and/or is otherwise worn by the user.", "These devices can be inconvenient for the user.", "Specifically, the wiring, which is usually arranged to run along the leg under the clothing to connect the device components, can be difficult to operate, cumbersome and uncomfortable.", "In other instances, an FES orthosis can be a self-contained device.", "For example, some known orthoses can include a stimulator unit coupled to a narrow band that is made of a thermoplastic material, which is molded to the limb anatomy of an individual user by heating and softening the thermoplastic material and subsequently fitting the band to the contour of the underlying limb segment.", "Thus, the shape and size of the device and the electrode positioning is custom-fitted to the leg of one user and individualized for the user.", "This procedure is carried out by a medical professional trained, for example, to accurately identify the stimulation points that cause contraction of the muscles, positioning and locking the electrodes thereto.", "Activation of the leg muscles by electrical stimulation typically includes transferring high stimulation currents through one or more electrodes to the skin surface of the patient, which activates skin sensory receptors in addition to underlying excitable motor nerve and muscle tissue.", "As a result, the intensity of sensory activation often depends on the intensity of the current density passing through the skin surface.", "The level of muscle activation, therefore, is often limited to the patient's individual tolerance to activation of such skin pain sensors.", "Thus, the stimulation parameters of the device are adjusted for each patient, which can be time consuming and often includes attaching the orthosis to a control device via wires.", "Therefore, a need exists for improved systems and apparatus for a neuroprosthetic system that can be easily and accurately donned on the limb by patient and that includes a stimulation unit that can be remotely controlled and/or adjusted.", "SUMMARY Systems and apparatus for gait modulation and methods of use are described herein.", "In some embodiments, an apparatus includes a frame assembly, a sensor, and an electric stimulator.", "The frame is configured to be removably coupled to a portion of a limb such that the portion of the limb is substantially enveloped by the frame.", "The sensor is operably coupled to the frame and is configured to produce a first signal associated with a gait characteristic at a first time, and a second signal associated with the gait characteristic at a second time, after the first time.", "The first time and the second time define a time period therebetween.", "The electric stimulator is removably coupled to the frame and is in electrical communication with the sensor and an electrode assembly.", "The electrode assembly is in electrical communication with a portion of a neuromuscular system of the limb when the frame is coupled thereto and is configured to receive the first signal from the sensor substantially at the first time and the second signal from the sensor substantially at the second time.", "Based at least in part on the gait characteristic at the first time, the electric stimulator is configured to send a third signal to the electrode assembly substantially at the first time operable to cause the electrode assembly to provide an electric stimulation to the portion of the neuromuscular system of the limb substantially during the time period.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a schematic illustration of a system for gait modulation according to an embodiment.", "FIG.", "2 is a perspective view of a functional electrical stimulation (FES) orthosis for gait modulation according to an embodiment.", "FIG.", "3 is a perspective view of a portion of the FES orthosis of FIG.", "2 illustrating coupling an electric stimulator to a frame.", "FIG.", "4 illustrates a portion of a patient donning the FES orthosis of FIG.", "2 on an impaired leg.", "FIG.", "5 is a schematic side view of a portion of the FES orthosis of FIG.", "2 illustrating an electrical connection between the electric stimulator of FIG.", "3 and an electrode assembly.", "FIG.", "6 is a rear perspective view of the FES orthosis of FIG.", "2 illustrating the electrode assembly of FIG.", "5 coupled to an inner surface of the frame of FIGS.", "3-5.FIG.", "7 is a schematic block diagram illustrating an electrical system of the FES orthosis of FIG.", "2.FIG.", "8 illustrates the FES orthosis of FIG.", "2 included in a system for gait modulation.", "FIG.", "9 is a flowchart illustrating a method of using an FES orthosis for gait modulation according to an embodiment.", "FIG.", "10 is a flowchart illustrating a method of using an FES system for gait modulation according to an embodiment.", "DETAILED DESCRIPTION The embodiments and methods described herein relate to an improved functional electrical stimulation (FES) orthosis for users suffering from gait problems such as drop foot.", "The orthosis can easily be donned on the leg, even by patients suffering from impairments that might otherwise hinder the donning of the orthosis.", "In some embodiments, an apparatus includes a frame assembly, a sensor, and an electric stimulator.", "The frame is configured to be removably coupled to a portion of a limb such that the portion of the limb is substantially enveloped by the frame.", "The sensor is operably coupled to the frame and is configured to produce at least a first signal associated with a gait characteristic at a first time, and a second signal associated with the gait characteristic at a second time, after the first time.", "The first time and the second time define a time period therebetween.", "The electric stimulator is removably coupled to the frame and is in electrical communication with the sensor and an electrode assembly.", "The electrode assembly is in electrical communication with a portion of a neuromuscular system of the limb when the frame is coupled thereto and is configured to receive the first signal from the sensor substantially at the first time and the second signal from the sensor substantially at the second time.", "Based at least in part on the gait characteristic at the first time, the electric stimulator is configured to send a third signal to the electrode assembly substantially at the first time operable to cause the electrode assembly to provide an electric stimulation to the portion of the neuromuscular system of the limb substantially during the time period.", "In some embodiments, a method includes receiving, at an electric stimulator and from a sensor, a first signal associated with a gait characteristic.", "Based at least in part on the first signal associated with the gait characteristic, one or more system parameters is calculated.", "A signal is sent, based at least in part on the one or more system parameters, from the electric stimulator to an electrode assembly to cause the electrode assembly to provide an electric stimulation to a portion of a neuromuscular system of a limb.", "A second signal associated with the gait characteristic is received at the electric stimulator from the sensor.", "The method includes terminating the electric stimulation of the portion of the neuromuscular system of the limb based on receiving the second signal associated with the gait characteristic.", "In some embodiments, a method of using an electric stimulator having a sensor and an electrode assembly in electrical communication with a portion of a neuromuscular system of a limb includes receiving, at the electric stimulator, a first signal that is sent from a control device via a first communication channel associated with a wireless communication over a network.", "The first signal is associated with a system parameter.", "A second signal is sent from the electric stimulator to the control device via the first communication channel.", "The second signal is associated with a confirmation of the system parameter.", "The electric stimulator receives a third signal that is sent from the sensor via a second communication channel, different from the first communication channel.", "The third signal is associated with a gait characteristic.", "The method includes sending, from the electric stimulator to the electrode assembly, a fourth signal.", "The fourth signal is operable to cause the electrode assembly to provide an electric stimulation to the portion of the neuromuscular system of the limb based at least in part on the system parameter and the gait characteristic.", "As used in this specification and the appended claims, the singular forms “a,” “an” and “the” include plural referents unless the context clearly dictates otherwise.", "Thus, for example, the term “a member” is intended to mean a single member or a combination of members, “a material” is intended to mean one or more materials, or a combination thereof.", "As used herein, the term “limb segment” refers to at least a portion of a mammalian appendage.", "For example, the embodiments described herein can be coupled to and/or otherwise placed in contact with a limb segment that can include a portion of the upper and/or lower arm, or a portion of the upper and/or lower leg of a human body.", "As used herein, the terms “envelop,” “enveloping,” and/or the like, with regard to a limb segment and an article or device coupled thereto, refer to an article or device that substantially surrounds and/or covers at least one half the circumference of a limb segment when coupled thereto.", "For example, if when coupled to a limb segment, an article or device substantially circumscribes a portion of the limb segment, the article or device can be said to envelop the portion of the limb segment.", "As used herein, the terms “FES orthosis,” “orthosis,” “neuroprosthetic,” “FES device,” “device,” and/or the like can be used interchangeably and refer generally to a medical apparatus that is selectively placed in contact with a portion of a patient.", "As described herein, such devices can include one or more electrodes that can transmit a flow of electrical current to a portion of a neuromuscular system associated with the portion of the patient, thereby providing functional electrical stimulation to, for example, an impaired limb.", "As used herein, the terms “reversible,” “reversibly,” and/or the like when used to described a process and/or procedure generally refer to a non-destructive process or procedure that can be subsequently undone by a similar yet substantially opposed, inverse, and/or opposite non-destructive process or procedure.", "When used herein with respect to attachment and/or detachment of an element or assembly, a reversible attachment refers to a non-destructive, repeatable attachment and/or detachment of the element or assembly.", "As used herein, the term “set” can refer to multiple features or a singular feature with multiple parts.", "For example, when referring to a set of walls, the set of walls can be considered as one wall with multiple portions, or the set of walls can be considered as multiple, distinct walls.", "Thus, a monolithically constructed item can include a set of walls.", "Such a set of walls may include multiple portions that are either continuous or discontinuous from each other.", "A set of walls can also be fabricated from multiple items that are produced separately and are later joined together (e.g., via a weld, an adhesive, or any suitable method).", "As used herein, the terms “about” and “approximately” generally mean plus or minus 10% of the value stated, unless the context clearly expresses otherwise.", "For example, about 0.5 would include 0.45 and 0.55, about 10 would include 9 to 11, about 1000 would include 900 to 1100.In some instances, such as when assessing a gait phase of a stimulation parameter and/or the like, the terms about and approximately can generally mean greater than plus or minus 10% of the value stated.", "As used herein, the terms “communication channel,” “communication mode,” and/or “modality” can be used interchangeably and refer generally to one or more modes of communication using, for example, one or more electronic devices.", "Such modes of communication can be associated with a specific format (e.g., a data unit format) that, in some instances, can be unique to that mode of communication (e.g., a different protocol, a different data unit structure or arrangement, etc.).", "For example, a cellular telephone (e.g., a smart phone) can send a communication to another electronic device such as an electric stimulator via a modality and/or via a network that is associated with the cellular telephone (e.g., a short message service (SMS) modality, a multimedia message service (MMS) modality, a Bluetooth® modality, a wireless fidelity (WiFi®) modality, etc.).", "Thus, when referring to a channel and/or modality, the channel and/or modality includes, defines, and/or otherwise is associated with a data unit format suitable for transmission of data via that communication mode.", "As used herein, the term “module” refers to any assembly and/or set of operatively-coupled electrical components that can include, for example, a memory, a processor, electrical traces, optical connectors, software (executing in hardware), and/or the like.", "For example, a module executed in the processor can be any combination of hardware-based modules (e.g., a field-programmable gate array (FPGA), an application specific integrated circuit (ASIC), a digital signal processor (DSP)) and/or software-based modules (e.g., a module of computer code stored in memory and/or executed at the processor) capable of performing one or more specific functions associated with that module.", "FIG.", "1 is a schematic illustration of a system 100 used for gait modulation according to an embodiment.", "For example, in some instances, the system 100 can be used by a human patient who has one or more impaired limbs as a result of injury and/or disease (e.g., stroke, spinal cord injury, head injury, cerebral palsy, multiple sclerosis, etc.).", "More specifically, the system 100 includes a functional electrical stimulation (FES) orthosis 105 (also referred to herein as “orthosis” and/or “device”) that is placed in physical and electrical contact with a limb 10 of the patient such as, for example, a lower limb segment of an impaired leg.", "As such, the patient and/or a health care professional (e.g., doctor, nurse, technician, physician, physical therapist, etc.)", "can engage the system 100 in such a manner as to cause the orthosis 105 to selectively provide electrical stimulation to a portion of a neuromuscular system of the limb 10, which can, in turn, facilitate gait of the patient who might otherwise experience, for example, drop foot or the like, as described in further detail herein.", "The orthosis 105 includes a frame 110, an electrode assembly 120, one or more sensors 130, and an electrical stimulator 140.In some embodiments, at least a portion of the orthosis 105 can be substantially similar in form and function as those described in U.S. Pat.", "No.", "7,899,556 entitled, “Gait Modulation System and Method,” filed Apr.", "27, 2006 (referred to henceforth as the “'556 patent”), U.S. Pat.", "No.", "8,209,036 entitled, “Gait Modulation System and Method,” filed Nov. 12, 2006 (referred to henceforth as the “'036 patent”), and U.S. patent application Ser.", "No.", "13/532,597 entitled, “Gait Modulation System and Method,” filed Jun.", "25, 2012 (referred to henceforth as the “'597 application”), the disclosures of which are incorporated herein by reference in their entireties.", "At least a portion of the frame 110 can be formed from a semi-rigid material such as, for example, a relatively thin metal, a thermoplastic, a polymer, and/or the like, which can enable the frame 110 to provide structural support for the orthosis 105.The frame 110 can have any suitable shape and/or size that can be, for example, associated with a segment of the limb 10 (e.g., a lower segment of a patient's leg).", "Moreover, at least a portion of the frame 110 can be transitioned between a first configuration and a second configuration to couple the frame 110 to the limb 10.For example, in some embodiments, the frame 110 can include a coupling portion or the like that can be transitioned between a first (e.g., open) configuration and a second (e.g., closed) configuration to at least temporarily couple the frame 110 to the limb 10.Expanding further, when the orthosis 105 is coupled to the limb 10, the frame 110 can be configured to substantially envelop and/or circumscribe the limb 10.In some embodiments, the coupling portion can be one or more straps, clips, ratchets, and/or the like that can allow for facile placement and coupling to the frame 110 to the limb 10, as described in further detail herein.", "The electrode assembly 120 of the orthosis 105 is coupled to an inner surface of the frame 110.As such, when the frame 110 is coupled to the limb 10 (e.g., transitioned from its first configuration to its second configuration), at least a portion of the electrode assembly 120 is placed in contact with a surface of the limb 10, as described in further detail herein.", "The electrode assembly 120 can be any suitable arrangement of hardware and/or software.", "For example, in some embodiments, the electrode assembly 120 can include one or more electrodes that are each electrically coupled to a wire, electrical trace, and/or the like that are operable in electrically coupling the one or more electrodes to the electric stimulator 140.In some embodiments, at least a portion of the electrode assembly 120 can be disposed within a portion of the frame 110.For example, in such embodiments, the electrode assembly can include a set of wires that are substantially enclosed by a portion of the frame 110.The wires can include end portions that each include a connector or the like that can, for example, be electrically coupled to the electric stimulator 140 at a first end portion and that can, for example, be electrically coupled to the electrodes at a second end portion.", "In some embodiments, the electrode assembly 120 can be substantially similar in form and function as those described in the '556 patent, the '036 patent, and/or the '597 application.", "The sensor 130 of the orthosis 105 can be any suitable sensor device or can include a combination of sensor devices.", "For example, in some embodiments, the sensor 130 can include a tilt sensor, an accelerometer, a gyroscope, a pressure sensor, a speedometer, and/or the like.", "In this manner, when the system 100 is used for gait modulation of a patient with an impaired limb (i.e., leg), the sensor 130 can be configured to sense and/or otherwise detect a characteristic associated with, for example, a gait event such as position of the sensor 130 relative to the orthosis 105, position of the limb 10 relative to a reference plane or the like, angular position of the limb 10 relative to a reference plane or the like, velocity, rate of change in velocity (i.e., acceleration), tilt of the patient's foot, pressure (e.g., when the foot and/or shoe contacts a surface upon which the patient is walking), etc.", "In some embodiments, the sensor 130 can be included in and/or integrated with the frame 110, the electrode assembly 120, and/or the electric stimulator 140.In other embodiments, the sensor 130 can be physically distinct from the orthosis 105 and in electrical communication with the electric stimulator 140 via a wireless communication channel.", "For example, in some embodiments, the electric stimulator 140 can be coupled to the frame 110, which in turn, is coupled to a first segment of the limb (e.g., adjacent to the knee of the patient's leg) and the sensor 130 can be coupled to and/or otherwise can be associated with a second segment of the limb 10 (e.g., adjacent to the foot and/or ankle of the patient's impaired leg).", "In some embodiments, the sensor 130 can be coupled and/or otherwise can be associated with a segment of the contralateral leg (e.g., adjacent to the foot and/or ankle of the patient's leg not donning the electric stimulator 140).", "In some embodiments, the system 100 can include multiple distinct sensors 130.For example, in some embodiments, the system 100 can include a first sensor that is integrated with the electric stimulator 140 and a second sensor that is physically distinct from, yet in electrical communication with, the electric stimulator 140 (e.g., disposed within and/or coupled to a shoe of the patient).", "In such embodiments, the electrical stimulator 140 can be configured to receive signals from and/or send signals to the first sensor via a first communication channel, associated with a wired signal transmission (e.g., signals transmitted along a wire or signal trace), and a second communication channel, associated with a wireless signal transmission (e.g., WiFi®, Bluetooth®, etc.", "), as described in further detail herein.", "The electric stimulator 140 of the orthosis 105 can be any suitable functional electrical stimulation device having any combination of hardware and software.", "For example, the electric stimulator 140 can be an electronic device that can include one or more electrical circuits operable in providing a flow of electrical current to at least a portion of the neuromuscular system of the limb 10.The electric stimulator 140 of the orthosis 105 is removably coupled to the frame 110.For example, in some embodiments, the frame 110 can form a cradle and/or the like that can be configured to at least temporarily retain the electrical stimulator 140 therein, as described below with respect to specific embodiments.", "Moreover, the electric stimulator 140 is configured to be placed in electrical communication with the electrode assembly 120 and the sensor 130.In some embodiments, the electrode assembly 120 and/or the sensor 130 can be included in (e.g., integrated with) the electric stimulator 140.In other embodiments, the electrode assembly 120 and the sensor 130 can be operably coupled to the electric stimulator 140 via any suitable wiring, connector, interface, and/or structure.", "For example, in some embodiments, the frame 110 can include a connector and/or the like configured to place the electric stimulator 140 in electrical communication with, for example, the electrode assembly 120 and/or the sensor 130.In some embodiments, the electric stimulator 140 can receive and/or send signals to a set of external and/or implanted electrical devices via any suitable communication mode.", "For example, in some embodiments, the electric stimulator 140 can include two, three, four, five, six, or more communication and/or electrical channels that can be operable in sending and/or receiving signals to and/or from, respectively, the electrode assembly 120, the sensor 130, and/or any other suitable electronic device operably coupled thereto.", "In some embodiments, at least a portion of the communication and/or electrical channels can be associated with sending and/or receiving signal via a wireless communication modality (e.g., a modality, format, and/or the like associated with WiFi®, Bluetooth®, near field communication (NFC), cellular communication such as, short message service (SMS) or multimedia message service (MMS), and/or the like), as described in further detail herein.", "As described above, in some instances, the system 100 can be used for gait modulation of patients with an impaired limb.", "More specifically, the system 100 can be used to enhance the limb function of a patient experiencing drop foot.", "In such instances, the patient can manipulate the orthosis 105 in such a manner as to couple the orthosis 105 to the impaired limb.", "For example, the patient can position the orthosis 105 adjacent to the knee of an impaired leg and can transition the frame 110 from a first configuration to a second configuration (as described above) to removably couple the orthosis 105 to the leg.", "The placement of the orthosis 105 can be such that a set of electrodes included in the electrode assembly 120 are disposed in a location relative to the leg that is associated and/or corresponds to a desired portion of the neuromuscular system of the leg.", "More specifically, to enhance the leg function of a patient experiencing drop foot during gait, the orthosis 105 can be positioned relative to the leg to place the electrodes in electric communication with the peroneal nerve and/or the tibial nerve.", "Thus, the electrodes can transmit functional electrical stimulation to the peroneal nerve, which can result in dorsiflexion of the foot, and/or the tibial nerve, which can result in plantarflexion of the foot, thereby enhancing the function of the impaired leg to mitigate the effects of drop foot, as described in further detail herein.", "With the frame 110 retained in the desired position relative to the impaired leg, the patient can begin walking.", "During walking, the sensor 130 can be configured to sense and/or detect a set of characteristics (such as those described above) associated with a gait event and can send a signal associated with the characteristic to the electric stimulator 140.For example, in some embodiments, the gait event can be associated with a “heel-off” event (i.e., the point during gait at which the heel is lifted off the surface upon which the patient is walking).", "The sensor 130 can send the signal to the electric stimulator 140 via any suitable communication channel.", "For example, if the sensor 130 is collocated with at least a portion of the electric stimulator 140 and/or the frame 110, the sensor 130 can send the signal via a communication channel associated with a wired signal transmission.", "If, however, the sensor 130 is physically distinct from the other portions of the orthosis 105, the sensor can send the signal via a communication channel associated with a wireless signal transmission, such as those described above.", "In some embodiments, the electric stimulator 140 can receive a signal from multiple sensors 130 that can be configured to sense and/or detect a characteristic associated with a gait event at different segments along the leg of the patient.", "Upon receiving the signal from the sensor 130, the electric stimulator 140 can be configured to transmit an electrical current resulting from a relatively high voltage (e.g., generated by a power supply or the like included in the electric stimulator 140) along an electric circuit that is electrically coupled to the electrode assembly 120.Thus, the current resulting from the relatively high voltage (also referred to herein as “high current”) is transmitted to the electrodes of the electrode assembly 120, which in turn, provide FES to the peroneal nerve, thereby resulting in dorsiflexion and/or plantarflexion of the foot substantially at the time of the heel-off event (e.g., a very short time after the sensor 130 detects the heel-off event consistent with a rate of electrical signal and/or electrical current transmission such as, 0.10 seconds, 0.05 seconds, 0.01 seconds, 0.001 seconds, 0.0001 seconds, or less).", "As a result, the foot of the patient flexes toward the leg, enhancing a portion of the patient's gait.", "In some instances, the sensor 130 can sense and/or detect a characteristic associated with a second gait event such as, for example, a “heel-on” event (i.e., the point during gait at which the heel is placed in contact with the surface of upon which the patient is walking).", "As described above, the sensor 130 can send a signal associated with the characteristic to the electric stimulator 140 and, upon receipt, the electric stimulator 140 can terminate the flow of the relatively high current to the electrodes in electrical contact with the peroneal nerve.", "In some instances and in a substantially concurrent process, the electric stimulator 140 can generate a relatively high current along an electric circuit that is electrically coupled to one or more electrodes in electrical communication with the tibial nerve.", "Thus, the electrodes can provide FES to the tibial nerve resulting in plantarflexion of the foot substantially at the time of the heel-on event (as described above).", "In this manner, the termination of the FES to the peroneal nerve relaxes the portion of the neuromuscular system resulting in a relaxation of the dorsiflexion, while substantially concurrently, the FES provided to the tibial nerve results in plantarflexion of the foot.", "As such, the foot flexes away from the leg, enhancing a portion of the patient's gait.", "In some embodiments, the electric stimulator 140 can include, for example, a memory or the like that can be configured to store information at least partially defining a set parameters associated with the FES.", "For example, in some embodiments, the electrical stimulator 140 can be configured to store information associated with a voltage and/or current level associated with the FES, a sensitivity associated with the sensor 130, a repository of actions to perform based on information received from the sensor 130, and/or any other suitable information and/or logic.", "Thus, the electric stimulator 140 can be configured to provide FES to the impaired leg with a set of characteristics that can be uniquely associated with the patient.", "In some instances, the patient and/or a health care professional can manipulate the electric stimulator 140 to change one or more parameters and/or characteristics associated with the FES provided to the impaired leg.", "As shown in FIG.", "1, in some embodiments, the electric stimulator 140 can be in communication with a control device 160.The control device 160 can be any suitable electronic device that can provide an interface for a user (e.g., the patient and/or a health care professional) to manipulate one or more characteristics and/or parameters associated with the FES.", "For example, in some embodiments, the control device 160 can be, for example, a personal computer (PC), a personal digital assistant (PDA), a smart phone, a laptop, a tablet PC, a server device, a workstation, and/or the like.", "The electronic device can include at least a memory (e.g., a random access memory (RAM), a memory buffer, a hard drive, a read-only memory (ROM), an erasable programmable read-only memory (EPROM), and/or the like); a processor (e.g., a general purpose processor, a central processing unit (CPU), an accelerated processing unit (APU), and Application Specific Integrated Circuit (ASIC), and/or the like); a network interface (e.g., a network interface card and/or the like that can include at least an Ethernet port and/or a wireless radio (e.g., a WiFi® radio, a Bluetooth® radio, etc.", ")); and an output device (e.g., a display such as a cathode ray tube (CRT) monitor, a liquid crystal display (LCD) monitor, a light emitting diode (LED) monitor, and/or the like, a Universal Serial Bus (USB) drive, an ANT+ compatible device or application, and/or any other suitable output device).", "In this manner, the control device 160 can be in communication with the electric stimulator 140 via the network interface and the processor can be configured to run or execute a set of instructions or code stored in the memory associated with using, for example, a PC application, a mobile application, an interne web browser, a cellular and/or wireless communication (via a network), and/or the like to communicate with and/or otherwise control at least a portion of the electric stimulator 140, as described herein with respect to specific embodiments.", "FIGS.", "2-8 are illustrations of a system 200 used, for example, in gait modulation according to an embodiment.", "For example, in some instances, the system 200 can be used by a human patient who has one or more impaired limbs as a result of injury and/or disease (e.g., stroke, spinal cord injury, head injury, cerebral palsy, multiple sclerosis, etc.).", "More specifically, the system 200 includes a functional electrical stimulation (FES) orthosis 205 (also referred to herein as “orthosis” and/or “device”) that is placed in physical and electrical contact with, for example, a lower limb segment of an impaired leg 20 (see e.g., FIG.", "4).", "In some embodiments, at least a portion of the orthosis 205 can be substantially similar in form and/or function to those described in the '556 patent, the '036 patent, and the '597 application incorporated by reference in their entireties above.", "As such, the patient and/or a health care professional (e.g., doctor, nurse, technician, physician, physical therapist, etc.)", "can engage the system 200 in such a manner as to cause the orthosis 205 to selectively provide functional electrical stimulation to a portion of a neuromuscular system of the leg 20, which can, in turn, facilitate gait of the patient who might otherwise experience, for example, drop foot or the like, as described in further detail herein.", "As shown in FIGS.", "2-7, the orthosis 205 includes a frame 210, an electrode assembly 220, and an electrical stimulator 240.Although not shown in FIGS.", "2-7, the orthosis 205 can also include and/or otherwise be operably coupled to one or more sensors 230, as shown and described herein with reference to FIGS.", "7 and 8.The frame 210 of the orthosis 205 can have any suitable shape and/or size that can be, for example, associated with a segment of the leg 20 and includes at least a portion that can be transitioned between a first configuration and a second configuration to couple the frame 210 to the leg 20.In some embodiments, the frame 210 can have a shape and size that are associated with a portion of the lower leg (e.g., between the knee and the foot of the lower leg).", "As such, an upper portion of the frame 210 can form an ergonomic contour that can, for example, substantially correspond with a shape of an inferior border of a patella 21 of a knee of the leg 20 (see e.g., FIG.", "4).", "Moreover, the frame 210 can define an ergonomic cross-sectional shape taken about a plane that is normal to a longitudinal axis of the frame 210 (e.g., substantially coaxial with an axis defined by the segment of the leg 20) that corresponds to and/or otherwise is associated with a shape of a tibial crest 22 of the lower leg (see e.g., FIG.", "4).", "In some embodiments, the frame 210 can be substantially similar in form and/or function as those described in the '556 patent, the '036 patent, and/or the '597 patent.", "As shown in FIGS.", "2-5, the frame 210 includes an inner structure 211, a cradle 212, a coupling portion 214, and a cover 216.At least a portion of the inner structure 211 can be formed from a semi-rigid material such as, for example, a relatively thin metal, a thermoplastic, a polymer, and/or the like.", "In this manner, the inner structure 211 can be sufficiently rigid to provide structural support for the orthosis 205, while being sufficiently flexible to allow the limb about which the inner structure 211 is disposed to increase or decrease during, for example, muscle flexion or muscle relaxation, respectively.", "As shown in FIG.", "3, the inner structure 211 can be substantially C-shaped such as to allow the inner structure 211 to expand and contract in response to the expansion and contraction of the leg 20, respectively.", "Moreover, the arrangement of the inner structure 211 can be such that when the size of the leg 20 is reduced (e.g., after expansion due to muscle flexion), the rigidity of the inner structure 211 can be sufficient to transition the inner structure 211 to a size and shape associated with the reduced size of the leg 20.Similarly stated, the inner structure 211 be biased such that when an external force expands the inner structure 211 to an expanded size is removed, the inner structure 211 returns to an unexpanded size, smaller than the expanded size.", "Thus, this arrangement enables the frame 210 to substantially envelop the portion of the leg 20, and serves to effectively disperse a pressure and/or strain that would otherwise be exerted on the portion of the leg 20, thereby retaining the natural profile and geometry of the leg 20 tissue and/or muscles when coupled thereto.", "In some embodiments, the inner structure 210 can be substantially similar in form and/or function as a central frame described in the '556 patent, the '036 patent, and/or the '597 patent.", "The cradle 212 of the frame 210 extends from the inner structure 211 to define a recess within which the electric stimulator 240 can be disposed.", "Similarly stated, the cradle 212 includes and/or is otherwise formed by a relatively thin set of walls extending from an outer surface of the inner structure 211 that have a size and a shape that are associated with the electric stimulator 240.The cradle 212 can include any suitable surface finish, protrusion, detent, etc.", "that can act to at least temporarily retain the electric stimulator 240 within the walls forming the cradle 212.For example, in some embodiments, the cradle 212 can form and/or define a set of detents that can matingly receive a set of corresponding protrusions extending from an outer surface of the electric stimulator 240 when therein (or vice versa).", "In other embodiments, an inner surface of the cradle 212 can have a finish and/or can be formed from a material with a relatively high coefficient of friction.", "Thus, when the electric stimulator 240 is disposed within the cradle 212 an outer surface of the electric stimulator 240 and an inner surface of the cradle 212 can form and/or define a friction fit that can at least temporarily retain the electric stimulator 240 in the cradle 212.As shown in FIGS.", "3 and 4, the cradle 212 includes and/or forms a connector 213 that can be electrically coupled to a corresponding connector (not shown in FIGS.", "2-8) of the electric stimulator 240.Moreover, the connector 213 is electrically coupled to a connector 222 of the electrode assembly 220 (described in further detail herein).", "Therefore, when the electric stimulator 240 is positioned within the cradle 212, the connector 213 can place the electric stimulator 240 in electrical communication with the electrode assembly 220, as described in further detail herein.", "Although described above as electrically connecting the electric stimulator 240 to the electrode assembly 220, in some embodiments, the connector 213 can be configured to electrically connect any number of electrical devices (e.g., one or more sensors and/or the like) to the electric stimulator 240 and/or the electrode assembly 220.The coupling portion 214 of the frame 210 can be transitioned between a first (e.g., open) configuration and a second (e.g., closed) configuration to reversibly couple the frame 210 to the leg 20.Said another way, the frame 210 can be positioned about a portion of the leg 20 and the coupling portion 214 can be transitioned to the second configuration to removably couple (i.e., at least temporarily couple) the frame 210 to the leg 20, as shown in FIG.", "4.The coupling portion 214 includes substantially parallel, modular straps (e.g., elastic straps, inelastic straps, and/or straps including one or more elastic portions and one or more inelastic portions) connecting between the frame 210 and a handle 215.The arrangement of the coupling portion 214 is such that during donning, the straps wrap circumferentially around the limb segment (e.g., the leg 20), to securely couple the orthosis 205 to the limb segment.", "In some embodiments, the handle 215 can form and/or provide a structure that can facilitate the engagement of the coupling portion 214.For example, in some embodiments, the handle can facilitate the engagement and/or manipulation of the coupling portion 214 by a patient who may have impairment in one or both hands.", "The cover 216 of the frame 210 can be configured to substantially enclose the inner structure 211 and includes an (see e.g., FIGS.", "2 and 6).", "The cover 216 can be formed from any suitable material and/or combination of materials.", "For example, in some embodiments, the cover 216 can be formed from a relatively flexible and/or soft material that can elastically deform when exposed to an external force.", "In some embodiments, the cover 216 can be, for example, over-molded about the inner structure 211.In other embodiments, the cover 216 can be removably disposed about the inner structure 211.In this manner, the cover 216 can enhance the ergonomics (e.g., comfort) of the frame 210 by forming a relatively flexible and/or soft layer that is placed in contact with the patient.", "As shown in FIGS.", "5 and 6, the cover 216 includes one or more couplers 217 that can engage a portion of the electrode assembly 220.The couplers 217 can be any suitable shape, size, or configuration.", "For example, in some embodiments, the couplers 217 can form a button, a snap, a detent, a protrusion, one half of a hook-and-loop coupler (i.e., Velcro®), and/or the like.", "As such, the couplers 217 can each be matingly placed in contact with a corresponding portion of a different electrode 221 included in the electrode assembly 220 to at least temporarily retain the electrodes 221 in a substantially fixed position relative to the frame 210.In some embodiments, the position of the couplers 217, and hence the electrodes 221 coupled thereto, can be associated with a target portion of the neuromuscular system of the leg 20 such as, for example, the peroneal nerve and/or the tibial nerve.", "Thus, when the electric stimulator 240 is disposed in the cradle 212 of the frame 210, the connector 213 of the inner structure 211 and the connector 222 of the electrode assembly 220 (described above) electrically couple the electric stimulator 240 to the electrodes 221 such that a relatively high current can flow from the electric stimulator 240 and through the electrodes 221 to provide functional electrical stimulation to the portion of the neuromuscular system of the leg 20, as described in further detail herein.", "Although the electrodes 221 are particularly shown and described with reference to FIGS.", "5 and 6, in other embodiments, the electrodes 221 can be any suitable configuration.", "For example, in some embodiments, the orthosis 205 can include one, two, three, four, five, six, or more electrodes disposed at different positions along the inner surface of the cover 216.Moreover, while the inner surface of the cover 216 is shown as including discrete couplers 217, in other embodiments, any number of electrodes 221 can be coupled directly to the inner surface and retained in a substantially fixed position relative to the frame 210.In some embodiments, the electrodes 221 and/or the electrode assembly 220 can be substantially similar in form and function as those described in the '556 patent, the '036 patent, and/or the '597 patent.", "The sensor 230 (see e.g., FIG.", "7) of the orthosis 205 can be any suitable sensor device or can include a combination of sensor devices.", "For example, in some embodiments, the sensor 230 can include a tilt sensor, an accelerometer, a gyroscope, a pressure sensor, a speedometer, and/or the like.", "In this manner, when the system 200 is used for gait modulation of a patient with the impaired leg 20, the sensor 230 can be configured to sense and/or otherwise detect a characteristic associated with, for example, a gait event such as position of the sensor 230 relative to the orthosis 205, position of the leg 20 relative to a reference plane or the like, angular position of the leg 20 relative to a reference plane or the like, velocity, rate of change in velocity (i.e., acceleration), tilt of the patient's foot, pressure (e.g., when the foot and/or shoe contacts a surface upon which the patient is walking), etc.", "As described above, in some embodiments, the sensor 230 can be included in and/or integrated with the frame 210, the electrode assembly 220, and/or the electric stimulator 240.In other embodiments, the sensor 230 can be physically distinct from the orthosis 205 and in electrical communication with the electric stimulator 240 via a wireless communication channel.", "For example, in some embodiments, the electric stimulator 240 can be coupled to the frame 210, which in turn, is coupled to a first segment of the leg 20 (e.g., adjacent to the knee of the patient as shown in FIG.", "4) and the sensor 230 can be coupled to and/or otherwise can be associated with a second segment of the leg 20 (e.g., adjacent to the foot and/or ankle of the patient's impaired leg).", "By way of example, the sensor 230 can be at least temporarily coupled the patient's shoe worn on the foot of the impaired leg 20 (see e.g., FIG.", "8).", "In some embodiments, the sensor 230 can be coupled and/or otherwise can be associated with a segment of the contralateral leg (e.g., adjacent to the foot and/or ankle of the patient's leg not donning the electric stimulator 240).", "In some embodiments, the system 200 can include multiple distinct sensors 230.For example, in some embodiments, the system 200 can include a first sensor that is integrated with the electric stimulator 240 and a second sensor that is physically distinct from, yet in electrical communication with, the electric stimulator 240 (e.g., disposed within and/or coupled to a shoe of the patient).", "In such embodiments, the electrical stimulator 240 can be configured to receive signals from and/or send signals to the first sensor via a first communication channel, associated with a wired signal transmission (e.g., signals transmitted along a wire or signal trace), and a second communication channel, associated with a wireless signal transmission (e.g., WiFi®, Bluetooth®, etc.", "), as described in further detail herein.", "In some embodiments, the sensor 230 can be substantially similar in form and/or function as those described in U.S. Pat.", "Ser.", "No.", "7,632,239 entitled, “Sensor Device for Gait Enhancement,” filed Oct. 23, 2006, U.S. Pat.", "Ser.", "No.", "8,382,688 entitled, “Sensor Device for Gait Enhancement,” filed Dec. 4, 2009, and U.S. Patent Application Publication No.", "2009/0069865 entitled, “Functional Electrical Stimulation Systems,” filed May 1, 2007, the disclosures of which are incorporated herein by reference in their entireties.", "The electric stimulator 240 can be any suitable electronic device configured to generate a flow of a relatively high current.", "As described above, the electric stimulator 240 can be positioned within the cradle 212 of the frame 210 to at least temporarily couple the electric stimulator 240 thereto.", "As shown in FIG.", "7, the electric stimulator 240 includes a battery 242 and a power supply 243 that are in electrical communication with a high voltage circuit 244, a digital circuit 245, and a stimulation circuit 249.The battery 242 can be any suitable battery and/or other source of electrical power.", "For example, in some embodiments, the battery 242 can be a relatively low profile rechargeable battery (e.g., a coin battery or the like).", "Similarly, the power supply 243 can be any suitable power supply, converter, conditioner, inverter, capacitor, and/or the like.", "The power supply 243 can be electrically coupled to the battery 242 via any suitable circuit and/or interface.", "In this manner, the power supply 243 can receive a flow of electrical current from the battery 242 and convert, amplify, condition, and/or otherwise change one or more attributes associated with the electrical current received from the battery 242.For example, in some embodiments, the power supply 243 can be configured to increase a voltage associated with at least a portion of the electrical current received from the battery 242.In some embodiments, the power supply 243 can receive electrical current from the battery 242 and can, for example, increase and/or convert a voltage of a first portion of the electrical current by a first amount (e.g., to a first voltage), and increase and/or convert a voltage of a second portion of the electrical current by a second amount (e.g., to a second voltage), less than the first amount.", "In such embodiments, the power supply 243 can include a first electrical circuit (not shown in FIG.", "7) that is associated with the first voltage (i.e., the higher voltage) and that is electrically coupled to the high voltage circuit 244.Similarly, the power supply 243 can include a second electrical circuit (not shown in FIG.", "7) that is associated with the second voltage (i.e., the lower voltage) and that is electrically coupled to the digital circuit 246.Thus, the power supply 243 can receive a flow of current from the battery 242 and can convert the flow of current into a first portion having a relatively high voltage suitable for the high voltage circuit and a second portion having a relatively low voltage suitable for the digital circuit.", "The high voltage circuit 244 can include any suitable electrical component.", "For example, although not shown in FIG.", "7, the high voltage circuit 244 can include a capacitor, resistor, logic gate, wire, electrical trace, and/or the like.", "The high voltage circuit 244 is in electrical communication with the stimulation circuit 245 and is configured to provide a flow of electrical current having the relatively high voltage (described above) thereto.", "The digital circuit 245 can be any suitable electrical circuit including any suitable electrical component.", "For example, as shown in FIG.", "7, the digital circuit 245 includes at least a memory 246, a processor 247, and a communication device 248 that are each electrically coupled via, for example, a set of wires, signal traces, and/or the like (not shown in FIG.", "7).", "Although not shown in FIG.", "7, the digital circuit 245 can also include one or more sensors 230 that can be in electrical communication with the memory 246, the processor 247, and/or the communication device 248 via the set of wires, signal traces, and/or the like.", "Moreover, the components of the digital circuit 245 can be in electrically coupled to the power supply 243 via one or more wires, signal traces, and/or the like.", "The memory 246 can be, for example, a random access memory (RAM), a memory buffer, a hard drive, a read-only memory (ROM), an erasable programmable read-only memory (EPROM), and/or the like.", "In some embodiments, the memory 246 can be configured to store, for example, one or more modules that can include instructions to cause the processor 247 to perform one or more processes, functions, and/or the like.", "For example, in some embodiments, the memory 246 can store instructions and/or code representing one or more parameters associated with providing FES to a patient, as described in further detail herein.", "The processor 247 of the digital circuit 245 can be any suitable processing device configured to run and/or execute a set of instructions or code such as, for example, a general purpose processor (GPU), a central processing unit (CPU), an accelerated processing unit (APU), an application specific integrated circuit (ASIC), a front end processor, a field programmable gate array (FPGA), and/or the like.", "As such, the memory 246 can store instructions to cause the processor 247 to execute modules, processes, and/or functions associated with providing FES to the patient.", "In this manner, based on the instructions stored by the memory 246, the processor 247 can change, modify, update, and/or otherwise control one or more parameters associated with FES.", "For example, in some instances, the memory 246 can include instructions to cause the processor 247 to perform one or more functions, processes, and/or modules based on receiving a signal from the sensor 230 (e.g., in communication with the digital circuit 245, as described in further detail herein).", "In some such instances, the functions, processes, and/or modules can be operable in providing and/or terminating a flow of relatively high current to the electrode assembly 220, as described in further detail herein.", "The communication device 248 of the digital circuit 245 can be any suitable device that can communicate with one or more electrical components and/or with one or more networks.", "For example, the communication device 248 can include one or more wired and/or wireless interfaces, such as, for example, Ethernet interfaces, optical carrier (OC) interfaces, and/or asynchronous transfer mode (ATM) interfaces.", "In some embodiments, the communication device 248 can be, for example, a network interface card and/or the like that can include at least an Ethernet port and/or a wireless radio (e.g., a WiFi® radio, a Bluetooth® radio, cellular network radio (e.g., global system for mobile communications (GSM), personal communications service (PCS), digital advanced mobile phone service (D-AMPS), etc.).", "In this manner, the communication device 248 can be configured to place the orthosis 205 in electrical communication (e.g., via a wired or wireless connection) with any suitable external device such as, for example, a control device, a sensor, a second orthosis (similar to or different from the orthosis 205), and/or the like via one or more networks.", "Such a network can be, for example, a local area network (LAN), a wide area network (WAN), a metropolitan area network (MAN), a worldwide interoperability for microwave access network (WiMAX), a telephone network, an intranet, the Internet, an optical fiber (or fiber optic)-based network, a virtual network, a cellular network (e.g., GSM, PCS, D-AMPS, etc.", "), and/or any other suitable network.", "By way of example, in some embodiments, the communication device 248 can be configured to receive signals from and/or send signals to the sensor 230 coupled to the shoe worn on the foot of the impaired leg 20 via Bluetooth® (see e.g., FIG.", "8).", "As shown in FIG.", "7, the stimulation circuit 249 is in electrical communication with the high voltage circuit 244 and the digital circuit 245.The stimulation circuit 249 can include any suitable electrical component.", "For example, although not shown in FIG.", "7, the stimulation circuit 249 can include a capacitor, a resistor, a logic gate, a wire, an electrical trace, and/or the like.", "Moreover, the stimulation circuit 249 is electrically coupled to the electrode assembly 220.In this manner, the stimulator circuit 249 can receive a flow of relatively high current and can transmit the relatively high current to the electrodes 221 to, for example, provide FES to the leg 20.In some embodiments, the digital circuit 245 can be configured to send a signal to the stimulation circuit 249 that can, for example, control the output of the stimulation circuit 249.For example, the stimulation circuit 249 can include a component, processor, logic gate, and/or the like that can operable in switch the stimulation circuit 249 between a first configuration and a second configuration based on receiving or not receiving a signal from the digital circuit 245.By way of example, the first configuration can be associated with an open circuit or the like in which upon receiving the flow of current (i.e., the relatively high current) from the high voltage circuit 244, the stimulation circuit 249 does not transfer, transmit, and/or otherwise provide a flow of relatively high current to the electrode assembly 220.Conversely, the stimulation circuit 249 can receive a signal (e.g., a relatively low voltage electrical current signal) from the digital circuit 245 that can be operable in switching the stimulation circuit to its second configuration, which can be associated with a closed circuit or the like.", "Thus, when in the second configuration and upon receiving the flow of current from the high voltage circuit 244, the closed stimulation circuit 249 can transmit, transfer, and/or otherwise provide a flow of relatively high current to the electrode assembly 220.As such, the electrode assembly 220 can provide FES (via the electrodes 221) to a portion of the neuromuscular system of the leg 20.As described above, in some instances, the system 200 can be used for gait modulation of the patient having the impaired leg 20.More specifically, the system 200 can be used to enhance the leg 20 function of the patient experiencing drop foot.", "In such instances, the patient can manipulate the orthosis 205 in such a manner as to couple the orthosis 205 to the impaired leg 20.For example, the patient can position the orthosis 205 adjacent to the patella 21 of the impaired leg 20 and can transition the coupling portion 214 of the frame 210 from its first configuration to its second configuration to removably couple the orthosis 205 to the leg 20, as described above with reference to FIG.", "4.The placement of the orthosis 205 can be such that the electrodes 221 included in the electrode assembly 220 are disposed in a location relative to the leg 20 that is associated with and/or corresponds to the peroneal nerve and/or the tibial nerve.", "Thus, the electrodes 221 can transmit functional electrical stimulation to the peroneal nerve, which can result in dorsiflexion of the foot, and/or the tibial nerve, which can result in plantarflexion of the foot, thereby enhancing the function of the impaired leg 20 to mitigate the effects of lower leg weakness, lower leg paralysis, and/or drop foot With the frame 210 retained in the desired position relative to the impaired leg 20 via the inner structure 211 and the coupling portion 214, the patient can begin walking.", "During walking, the sensor 230 can be configured to sense and/or detect a set of characteristics (such as those described above) associated with a gait event and can send a signal associated with the characteristic to the electric stimulator 240.For example, in some embodiments, the sensor 230 can be coupled to and/or disposed in a shoe worn on the foot of the impaired leg 20 and can be configured to sense and/or detect a gait event associated with a “heel-off” event based at least in part on a change in pressure.", "The sensor 230 can then send the signal to the electric stimulator 240 via, for example, a protected wireless communication channel.", "In other embodiments, the sensor 230 can be collocated with at least a portion of the electric stimulator 240 and/or the frame 210.As such, the sensor 230 can be configured to sense and/or detect the “heel-off” event based at least in part on an acceleration, tilt, relative position, and/or movement of the sensor 230.In this manner, the sensor 230 can send a signal via a communication channel associated with a wired signal transmission to the electric stimulator 240.In still other embodiments, the electric stimulator 240 can receive a signal from multiple sensors 230 that can be configured to sense and/or detect a characteristic associated with a gait event at different segments along the leg of the patient.", "For example, the electric stimulator 240 can receive a signal from a collocated sensor 230 via a first communication channel associated with a wired signal transmission and can receive a signal from a physically distinct sensor 230 via a second communication channel associated with a wireless signal transmission such as, for example, Bluetooth®.", "In this manner, the communication device 248 of the electric stimulator 240 can receive the signal from the sensor 230 and can forward the signal and/or otherwise send a signal representing the received signal to the processor 247.Upon receipt, the processor 248 can determine, reference, and/or calculate one or more system parameters based at least in part on information stored in the memory 246 and the signal sent from the sensor 230.In some instances, the processor 247 can perform one or more processes, functions, modules and/or the like that can, for example, cause the power supply 243 to generate and transmit a relatively high current along the high voltage circuit 244 to the stimulation circuit 249.In addition and substantially in a parallel process, the processor 247 can send a relatively low voltage electrical current signal to the stimulation circuit 249 that can, for example, place the stimulation circuit 249 in a closed state or the like.", "Thus, the relatively high current is transmitted to the electrodes 221 of the electrode assembly 220, which in turn provides FES to the peroneal nerve, thereby resulting in dorsiflexion of the foot substantially at the time of the heel-off event (e.g., a very short time after the sensor 230 detects the heel-off event as described above).", "As a result, the foot of the patient flexes toward the leg, enhancing a portion of the patient's gait.", "In some instances, the sensor 230 can sense and/or detect a characteristic associated with a second gait event such as, for example, a “heel-on” event (i.e., the point during gait at which the heel is placed in contact with the surface of upon which the patient is walking).", "As described above, the sensor 230 can send a signal associated with the characteristic to the electric stimulator 240 and, upon receipt, the processor 247 can send a signal to the power supply 243 to terminate the flow of the relatively high current to the high voltage circuit 244.In addition and in a substantially parallel process, the processor 247 can send a relatively low voltage electrical current signal to the stimulation circuit 249 that can, for example, place the stimulation circuit 249 in an open circuit state or the like.", "Thus, current is no longer transferred to the electrodes 221 in electrical contact with the peroneal nerve, thereby allowing the associated muscles to relax, which in turn results in the foot moving in a direction away from the leg.", "In this manner, the FES provided to the peroneal nerve can facilitate the gait of the patient.", "In other instances, the processor 247 need not send a signal to the power supply 243 to terminate the flow of relatively high current to the high voltage circuit 244.For example, in such instances, the stimulation circuit 249 can define multiple electrical circuits between the stimulation circuit 249 and different portions of the electrode assembly 240.In this manner, the processor 247 can send a signal to the stimulation circuit 249 that can be operable in opening the electrical circuit associated with the peroneal nerve, thereby terminating the FES provided thereto, and can be operable in closing a different electrical circuit associated with, for example, the tibial nerve.", "Thus, the relatively high current can flow along the now closed electric circuit that is electrically coupled to one or more electrodes 221 in electrical communication with the tibial nerve.", "As such, the electrodes 221 can provide FES to the tibial nerve resulting in plantarflexion of the foot substantially at the time of the heel-on event (as described above).", "More specifically, the termination of the FES to the peroneal nerve relaxes the portion of the neuromuscular system resulting in a relaxation of the dorsiflexion, while substantially concurrently, the FES provided to the tibial nerve results in plantarflexion of the foot.", "As a result, the foot flexes away from the leg, enhancing the patient's gait.", "In some embodiments, the memory 246 of the digital circuit 245 can store information at least partially defining a set parameters associated with the FES.", "For example, in some embodiments, the memory 246 can store information associated with a voltage and/or current level associated with the FES, a sensitivity associated with the sensor 230, a repository of actions to perform based on information received from the sensor 230, a skin sensitivity of the patient, and/or any other suitable information and/or logic.", "Thus, the electric stimulator 240 can be configured to provide FES to the impaired leg 20 with a set of characteristics that can be uniquely associated with the patient.", "In some instances, the patient and/or a health care professional can manipulate the electric stimulator 240 to change one or more parameters and/or characteristics associated with the FES provided to the impaired leg 20.For example, although not shown in FIGS.", "2-8, in some embodiments, the electric stimulator 240 can include an output device such as, for example, a display.", "In some instances, the display can, for example, provide a user interface for the patient and/or the health care professional to monitor, modify, and/or otherwise control the electric stimulator 240.Although the electric stimulator 240 is described above as providing FES to, for example, a first portion of the neuromuscular system of the patient, and upon receiving a signal from the sensor 230, terminating the FES to the first portion of the neuromuscular system and providing FES to, for example, a second portion of the neuromuscular system, in other embodiments, the electric stimulator 240 can be configured to provide FES to the first portion and the second portion of the neuromuscular system in substantially concurrent and/or complementary processes.", "Moreover, the processor 247 can be configured to perform and/or execute one or more processes, functions, and/or modules associated with selectively modulating a flow of electrical current to one or more portions of the neuromuscular system.", "For example, in some embodiments, the electric stimulator 240 can be configured to provide FES to a portion of the peroneal nerve, which can result in dorsiflexion of the foot on an impaired leg.", "Based at least in part on a signal received from the sensor 230, the processor 247 can perform one or more processes and/or functions that can, for example, reduce a voltage of the FES that is provided to the portion of the peroneal nerve, thereby reducing dorsiflexion of the foot.", "In a substantially parallel and/or concurrent process, the processor 247 can execute one or more functions that can close a circuit (e.g., within the stimulation circuit 249) or the like to provide FES to a second portion of the neuromuscular system (e.g., a second portion of the peroneal nerve and/or a portion of the tibial nerve) that can result in plantarflexion of the foot.", "In some instances, a voltage associated with the FES provided to cause plantarflexion can be increased in a substantially concurrent and/or inversely proportional process as the decrease in the voltage of the FES provided to cause dorsiflexion.", "In this manner, the processor 247 of the electric stimulator 240 can be configured to direct, divert, steer, and/or otherwise control a flow of current through, for example, the stimulation circuit 249 to selectively provide at least a portion of the flow of current to the electrode assembly 220.In some embodiments, the electrode assembly 220 can include one or more electrodes in electrical communication with a portion of the neuromuscular system that is associated with eversion or inversion of the foot.", "In such embodiments, a sensor (e.g., the sensor 230) can sense and/or determine a characteristic associated with eversion or inversion of the foot of an impaired leg and can send a signal associated with the characteristic to the electric stimulator 240.In this manner, the processor 247 can be configured to perform or execute one or more functions, processes, modules, and/or the like that is associated with directing, diverting, and/or otherwise controlling a flow of current through the stimulation circuit 249 such that a desired amount of FES is provided to the portion of the neuromuscular system controlling eversion and inversion (e.g., superficial portions of the peroneal nerve and/or the like).", "In some embodiments, the electrode assembly 220 can include a set of electrodes, with each electrode being in electrical communication with a different portion of the neuromuscular system.", "Moreover, the electrode assembly 220 can be electrically coupled to the electric stimulator 240 such that each electrode is in electrical connection with a different electric communication channel of the electric stimulator 240.In this manner, the set of electrodes can define and/or bound an area of stimulation to be applied to, for example, an impaired limb.", "As described above, the processor 247 can be configured to execute a set of instructions (e.g., stored in the memory 246) associated with increasing or decreasing a voltage provided to each electrode in a substantially concurrent process based at least in part on a signal received from the sensor 230 (or multiple sensors).", "Thus, the electric stimulator 240 can direct, steer, divert, and/or otherwise control (i.e., increase or decrease) a voltage provided to the set of electrodes to continuously control (e.g., during gait) an amount of dorsiflexion, plantarflexion, eversion, inversion, and/or the like to, for example, increase a stability of the impaired limb and/or the patient during gait.", "As shown in FIG.", "8, in some embodiments, the electric stimulator 240 can be in communication with one or more control devices 260 and 260′.", "The control device 260 can be any suitable electronic device that can provide an interface for a user (e.g., the patient and/or a health care professional) to manipulate one or more characteristics and/or parameters associated with the FES.", "For example, in some embodiments, the control device 260 can be, for example, a smart phone or the like that can be manipulated to run and/or execute a set of instructions associated with controlling the electric stimulator 240.Similarly, the control device 260′ can be a personal computer (PC), a laptop, a tablet PC, a server device, a workstation, and/or the like that can be manipulated to run and/or execute a set of instructions associated with controlling the electric stimulator 240.In some instances, the control device 260 can be in communication with the electric stimulator 240 via the communication device 248.Although shown in FIG.", "8 as being in communication with one or more control devices, in other embodiments, the electric stimulator 240 can include any suitable hardware and/or software that can, for example, enable to the electric stimulator to function as a control device.", "For example, in some embodiments, the electric stimulator 240 can include a user interface and/or the like that can be manipulated by a user to control at least a portion of the electric stimulator 240.In some instances, the electric stimulator 240 can be configured to communication with any number of electronic devices.", "For example, in some embodiments, the electric stimulator 240 can be in electrical communication with the control devices 260 and 260′, a physically distinct sensor 230, and an electric stimulator 240′ of a second orthosis 205′.", "In such embodiments, the electric stimulator 240 and/or the communication device 248 can be configured to communicate with the electronic devices via, for example, unique communication channels.", "Thus, the control devices 260 and 260′, the physically distinct sensor 230, and the orthosis 205 and 205′ can collectively provide FES to a patient that can, for example, enhance the patient's gait or the like.", "More specifically, in some embodiments, the orthosis 205′ can be configured to be disposed, for example, about the thigh of the patient donning the orthosis 205 (i.e., the thigh of the impaired leg).", "The electrodes (not shown) of the orthosis 205′ can be, for example, in electrical communication with one or more portions of the neuromuscular system associated with, for example, the hamstring and/or the quadriceps.", "In some embodiments, the orthosis 205′ can be substantially similar to or the same as the devices described in U.S. patent application Ser.", "No.", "13/022149 entitled, “Adjustable Orthosis for Electrical Stimulation of a Limb,” filed Feb. 7, 2011, the disclosure of which is incorporated herein by reference in its entirety.", "Thus, the electric stimulator 240 can be configured to communicate with the electric stimulator 240′ to provide FES to substantially the entirety of an impaired limb of the patient.", "Moreover, in some embodiments, the electronic stimulator 240′ can be substantially similar to or the same as the electric stimulator 240 and as such, can be in direct electric communication with the sensor 230′ (e.g., via a wired or wireless connection).", "In other words, the sensor 230′ can be configured to send a signal associated with a gait event to the electric stimulator 240 of the orthosis 205 and the electric stimulator 240′ of the orthosis 205.In some embodiments, the electric stimulator 240 can be in electrical communication with, for example, an electric stimulator 240″ of an orthosis 205″ disposed about a portion of a contralateral leg, as shown in FIG.", "8.For example, in some instances, a patient can have a physical impairment of both legs (either equally impaired or one leg having a greater level of impairment).", "In such instances, the patient can don the orthosis 205 on a first leg (as described above) and can don the orthosis 205″ on a second leg (i.e., the contralateral leg).", "Thus, the electric stimulator 240 of the orthosis 205 and the electric stimulator 240″ of the orthosis 205″ can be configured to communicate with each other, with the sensor 230′, the control devices 260 and/or 260′, and/or the electric stimulator 240′ orthosis 205′.", "Although not shown in FIG.", "8, in some embodiments, the electric stimulator 240 can be in electrical communication with an FES orthosis in electrical communication with any suitable portion of the neuromuscular system of the patient.", "For example, in some embodiments, the electric stimulator 240 of the orthosis 205 can be in electrical communication with an electric stimulator of an orthosis disposed about a portion of an impaired arm and/or the like.", "FIG.", "9 is a flowchart illustrating a method 1000 of using an FES orthosis for gait modulation according to an embodiment.", "The FES orthosis can be any suitable neuroprosthetic and/or the like such as the orthosis 100 and/or 200 described herein.", "As such, the orthosis can include a frame, an electrode assembly, a sensor, and an electric stimulator, and can be coupled to and/or disposed about an impaired leg of a patient to provide FES thereto.", "The method 1000 includes receiving, at the electric stimulator and from the sensor, a first signal associated with a gait characteristic, at 1001.For example, in some embodiments, the electric stimulator can be substantially similar in form and function as the electric stimulator 240 described above with reference to FIG.", "7.Similarly, the sensor can be substantially similar in form and function as the sensor 230 described above with reference to FIG.", "7.In this manner, the sensor can include one or more sensing devices such as, for example, a tilt sensor, pressure sensor, accelerometer, gyroscope, etc.", "that can sense and/or detect the gait characteristic.", "In some embodiments, the gait characteristic can be associated with, for example, a “heel-off” event or the like of the impaired leg (e.g., a decrease in pressure as a result of the heel being lifted away from a surface upon which the patient is walking and/or any other suitable characteristic).", "As such, the sensor can sense and/or detect the gait characteristic and can send the first signal to the electric stimulator.", "As described above, in some embodiments, the sensor can be integrated with the electric stimulator and as such, the first signal can be sent via a communication channel associated with a wired signal transmission (e.g., along a wire and/or a signal trace).", "In other embodiments, the sensor can be physically distinct from the electric stimulator, and as such, the first signal can be sent via a communication channel associated with a wireless signal transmission (e.g., WiFi®, Bluetooth®, etc.).", "Upon receipt, one or more system parameters are calculated based at least in part on the first signal associated with the gait characteristic, at 1002.For example, in some embodiments, the electric stimulator can include at least a memory and a processor.", "The memory can store instructions to cause the processor to perform and/or execute one or more functions, processes, modules, and/or the like associated with calculating the one or more system parameters.", "As such, the processor can receive the first signal from the sensor and can calculate and/or otherwise determine the one or more system parameters associated with that gait characteristic.", "By way of example, in some embodiments, the memory can include and/or can store a repository that includes a list of gait characteristics and a list of processes and/or functions to be executed by the processor that are associated therewith.", "In such embodiments, the processor can, for example, query the repository to determine the one or more system parameters associated with the first signal received from the sensor.", "In other embodiments, the electric stimulator can be in communication with a control device or the like (e.g., via a wired or wireless connection) that can include and/or store the repository.", "For example, in some embodiments, the control device can be substantially similar to the control device 260 described above with reference to FIG.", "8.Based at least in part on the one or more system parameters, a signal is sent from the electric stimulator to the electrode assembly to cause the electrode assembly to provide an electric stimulation to a portion of the neuromuscular system of the limb, at 1003.For example, in some embodiments, the FES orthosis can be disposed about and/or can at least partially envelop a portion of the impaired leg to substantially align and/or otherwise place one or more electrodes in electrical communication with, for example, the peroneal nerve of the impaired leg.", "Thus, electric stimulation is provided to a set of muscles associated with the portion of the neuromuscular system of the impaired leg, resulting in dorsiflexion of the foot of the impaired leg (i.e., a pivoting of the foot substantially about the ankle towards the leg).", "The method 1000 includes receiving, at the electric stimulator and from the sensor, a second signal associated with the gait characteristic, at 1004.For example, in some embodiments, the gait characteristic can be associated with a “heel-on” event or the like of the impaired leg (e.g., an increase in pressure as a result of the heel being placed in contact with the surface and/or any other suitable characteristic).", "As such, the sensor can sense and/or detect the gait characteristic and can send the second signal to the electric stimulator.", "Based on receiving the second signal associated with the gait characteristic, the electric stimulation of the portion of the neuromuscular system of the limb is terminated, at 1005.For example, in some embodiments, the electric stimulator can be configured to open an electrical circuit between a power supply (e.g., that generates the electric current for stimulation) and the electrode assembly.", "In other embodiments, the electric stimulator can transition the power supply or the like from an “on” state, in which electrical current is transmitted to the electrode assembly, to an “off” state or the like (e.g., sleep, hibernate, standby, etc.", "), in which electrical current is not transmitted to the electrode assembly.", "In still other embodiments, the electric stimulator can modulate an amount of stimulation (e.g., a voltage of the current provided to the electrode assembly) from a first amount resulting in, for example, the dorsiflexion of the limb to a second amount resulting in a substantially relaxing of the portion of the neuromuscular system.", "Said another way, the electric stimulator can modulate stimulation such that an intensity of the stimulation provided to the portion of the neuromuscular system of the limb is reduced (i.e., the electric stimulator does not substantially terminate the stimulation but reduces the amount of stimulation to a minimal setting and/or the like).", "As a result, the electric stimulation applied to, for example, the peroneal nerve is terminated and/or modulated, thereby allowing the set of muscles associated therewith to relax.", "Thus, the foot of the impaired leg can pivot about the ankle away from the leg (i.e., plantarflexion).", "In this manner, the FES orthosis can provide functional electrical stimulation that can enhance the function of the impaired leg to facilitate gait.", "Although the method 1000 described above includes the electric stimulator receiving a first signal and a second signal from the sensor, in some instances, the sensor can be configured to send any number of signals to the electric stimulator that can be, for example, associated with adjusting one or more parameters of the electric stimulation provided to the neuromuscular system of the limb.", "By way of example, in some instances, the sensor can send the signal to the electric stimulator (i.e., at 1003) and can be configured to sense and/or otherwise detect an amount of the dorsiflexion and/or inversion or eversion of the foot in response to the electric stimulation and based on the sensed and/or detected characteristic, can send one or more signals to the electric stimulator (i.e., prior to the signal sent at 1004) associated with adjusting one or more parameters of the electric stimulation (e.g., a voltage provided to one or more portions of the electrode assembly and/or the like).", "Although the method 1000 described above includes the electric stimulator terminating and/or modulating the electric stimulation based on receiving the second signal from the sensor, in some instances, the electric stimulator can terminate and/or modulate the electric stimulation based on any set of signals, parameters, history, and/or the like.", "For example, in some instances, the electric stimulator can receive the second signal from the sensor and can compare data included in and/or represented by the second signal with historical data such as, for example, a previous gait event and/or the like.", "As such, the electric stimulator can be configured to adjust, terminate, and/or modulate the electric stimulation provided to the portion of the neuromuscular based at least in part on the second signal and/or any other data associated with a gait event, characteristic, and/or parameter.", "FIG.", "10 is a flowchart illustrating a method 1100 of using an FES orthosis for gait modulation according to an embodiment.", "The FES orthosis can be any suitable neuroprosthetic and/or the like such as the orthosis 100 and/or 200 described herein.", "As such, the orthosis can include a frame, an electrode assembly, a sensor, and an electric stimulator, and can be coupled to and/or disposed about an impaired leg of a patient to provide FES thereto.", "The method 1100 includes receiving, at the electric stimulator and from a control device, a first signal that is associated with a system parameter via a first communication channel, at 1101.The control device can be any suitable device such as, for example, the control devices 160, 260, and/or 260′ described herein.", "The first communication channel can be associated with a wireless communication over a network.", "For example, the electric stimulator can include a communication device such as the communication device 248 in FIG.", "7, which can communicate with one or more electronic devices.", "The network and the communication channel can be any suitable network and communication channel, respectively, such as those described herein.", "By way of example, in some embodiments, the network can be a personal area network (PAN) and the communication channel can be associated with Bluetooth®.", "In some embodiments, the system parameter can be associated with, for example, an initialization of the FES orthosis.", "For example, in some embodiments, the patient can be receiving FES therapy for the first time and as such, system parameters and/or settings of the FES orthosis may not be appropriately defined for the patient.", "As such, a health care provider can manipulate the control device (e.g., a smart phone, a PC, a tablet, etc.)", "to define an initial set of system characteristics and/or a second of calibration parameters for the FES orthosis that are uniquely established for the patient.", "In some instances, with the first communication channel being associated with a wireless communication over a network, a health care professional can manipulate the control device to define the system parameter substantially remotely (e.g., at a location physically distinct from the FES orthosis).", "By way of example, the health care professional can be at a medical facility and can manipulate the control device to define the system parameter and can send the first signal via, for example, a LAN and the Internet to the FES orthosis worn by a patient that is at his or her home (or any other location other than the medical facility).", "Upon receipt of the first signal, a second signal that is associated with a confirmation of the system parameter is sent from the electric stimulator to the control device, at 1102.In some embodiments, the second signal can be sent in a similar manner as described with reference to the first signal.", "The electric stimulator receives a third signal that is from the sensor via a second communication channel, different from the first communication channel, at 1103.The sensor can be substantially similar in form and function as the sensor 230 described above with reference to FIG.", "7.In this manner, the sensor can include one or more sensing devices such as, for example, a tilt sensor, pressure sensor, accelerometer, gyroscope, etc.", "that can sense and/or detect the gait characteristic.", "In some embodiments, the gait characteristic can be associated with, for example, a “heel-off” event or the like of the impaired leg (e.g., a decrease in pressure as a result of the heel being lifted away from a surface upon which the patient is walking and/or any other suitable characteristic).", "In other embodiments, the gait characteristic can be associated with any suitable gait event.", "Based at least in part on the system parameter and the gait characteristic, a fourth signal is sent, from the electric stimulator to the electrode assembly, to cause the electrode assembly to provide an electric stimulation to a portion of a neuromuscular system of the limb (e.g., the impaired leg), at 1104.For example, in some embodiments, the FES orthosis can be disposed about and/or can at least partially envelop a portion of the impaired leg to substantially align and/or otherwise place one or more electrodes included in the electrode assembly in electrical communication with, for example, the peroneal nerve of the impaired leg.", "Thus, electric stimulation is provided to a set of muscles associated with the portion of the neuromuscular system of the impaired leg, resulting in dorsiflexion of the foot of the impaired leg (i.e., a pivoting of the foot substantially about the ankle towards the leg).", "Thus, the FES orthosis can be used to enhance limb function of the impaired leg to mitigate the effects of, for example, lower leg paralysis such as drop foot or the like.", "Although the embodiments and methods have been described above as providing functional electrical stimulation to an impaired leg of a patient experiencing, for example, drop foot, in other embodiments, the embodiments and methods can be used to enhance the function of any suitable limb or other portion of the body.", "By way of example, in some embodiments, an FES orthosis can include a frame, an electrode assembly, a sensor, and an electric stimulator and can be adapted to enhance the function of a patients hand or the like.", "In some instances, the sensor of such FES orthosis can be configured to sense and/or detect one or more characteristics associated with the function of the hand and can send a signal to the electric stimulator (in a similar manner as described above) that is associated with the one or more characteristics.", "As such, the electric stimulator can generate an electrical current that can be transmitted through one or more electrodes included in the electrode assembly, thereby providing FES to one or more nerves associated with the function of the hand.", "While the embodiments and methods have been described above as including an electrode assembly that is physically coupled to an FES orthosis and that is disposed adjacent to an external surface of the body of a patient, in other embodiments, an FES orthosis can include and/or can otherwise be coupled to an electrode assembly that can be at least partially disposed within a portion of the body of the patient.", "For example, in some embodiments, an FES orthosis can be operably coupled to an electrode assembly that includes electrodes disposed within the body of a patient.", "In some embodiments, at least a portion of the electrode assembly can be disposed within the body in such a manner that the electrodes are disposed adjacent to and/or in electrical communication with, for example, the peroneal nerve, the tibial nerve, and/or any other suitable portion of a neuromuscular system of the patient.", "In some embodiments, the electrode assembly can include one or more external connectors configured to place the electrodes disposed within the body in electrical communication with an electric device that is disposed externally of the body.", "In other embodiments, the electrode assembly need not include such connectors and can transmit a flow of electrical current via, for example, inductive coupling and/or the like.", "Although the embodiments and methods have been described above as including a sensor that can be integrate into an FES orthosis and/or that can be coupled to a structure substantially outside of the body (e.g., a shoe, the orthosis, etc.", "), in other embodiments, an FES orthosis can include and/or can otherwise be in communication with one or more sensors disposed within the body of a patient.", "For example, in some embodiments, a relatively small sensor can be subcutaneously implanted into a portion of the patient's foot, ankle, lower leg, upper leg, and/or any other suitable portion of the body.", "While various embodiments have been described above, it should be understood that they have been presented by way of example only, and not limitation.", "Where schematics and/or embodiments described above indicate certain components arranged in certain orientations or positions, the arrangement of components may be modified.", "While the embodiments have been particularly shown and described, it will be understood that various changes in form and details may be made.", "Although various embodiments have been described as having particular features and/or combinations of components, other embodiments are possible having a combination of any features and/or components from any of embodiments as discussed above.", "Where methods and/or events described above indicate certain events and/or procedures occurring in certain order, the ordering of certain events and/or procedures may be modified.", "Additionally, certain of the events may be performed concurrently in a parallel process when possible, as well as performed sequentially as described above.", "Some embodiments described herein relate to a computer storage product with a non-transitory computer-readable medium (also can be referred to as a non-transitory processor-readable medium) having instructions or computer code thereon for performing various computer-implemented operations.", "The computer-readable medium (or processor-readable medium) is non-transitory in the sense that it does not include transitory propagating signals per se (e.g., a propagating electromagnetic wave carrying information on a transmission medium such as space or a cable).", "The media and computer code (also can be referred to as code) may be those designed and constructed for the specific purpose or purposes.", "Examples of non-transitory computer-readable media include, but are not limited to, magnetic storage media such as hard disks, floppy disks, and magnetic tape; optical storage media such as Compact Disc/Digital Video Discs (CD/DVDs), Compact Disc-Read Only Memories (CD-ROMs), and holographic devices; magneto-optical storage media such as optical disks; carrier wave signal processing modules; and hardware devices that are specially configured to store and execute program code, such as Application-Specific Integrated Circuits (ASICs), Programmable Logic Devices (PLDs), Read-Only Memory (ROM) and Random-Access Memory (RAM) devices.", "Other embodiments described herein relate to a computer program product, which can include, for example, the instructions and/or computer code discussed herein.", "Some embodiments and/or methods described herein can be performed by software (executed on hardware), hardware, or a combination thereof.", "Hardware modules may include, for example, a general-purpose processor, a field programmable gate array (FPGA), and/or an application specific integrated circuit (ASIC).", "Software modules (executed on hardware) can be expressed in a variety of software languages (e.g., computer code), including C, C++, Java™, Ruby, Visual Basic™, and/or other object-oriented, procedural, or other programming language and development tools.", "Examples of computer code include, but are not limited to, micro-code or micro-instructions, machine instructions, such as produced by a compiler, code used to produce a web service, and files containing higher-level instructions that are executed by a computer using an interpreter.", "Additional examples of computer code include, but are not limited to, control signals, encrypted code, and compressed code." ] ]
Patent_15872634
[ [ "MOLDED FLUID FLOW STRUCTURE", "A fluid flow structure may include a fluid dispensing micro device comprising a tapered fluid port to feed fluid to the micro device, and a monolithic molding comprising a tapered channel defined in the molding through which fluid may flow directly into the micro device.", "The channel may be fluidically coupled to the fluid port.", "The micro device is embedded in the molding.", "The micro device is a printhead die having a thickness less than or equal to 650 μm.", "The channel is wider than the fluid port." ], [ "1.A fluid flow structure, comprising: a fluid dispensing micro device comprising a tapered fluid port to feed fluid to the micro device; and a monolithic molding comprising a tapered channel defined in the molding through which fluid may flow directly into the micro device, the channel being fluidically coupled to the fluid port, wherein the micro device is embedded in the molding, wherein the micro device is a printhead die having a thickness less than or equal to 650 μm, and wherein the channel is wider than the fluid port.", "2.The fluid flow structure of claim 1, wherein the channel is molded into the molding.", "3.The fluid flow structure of claim 1, wherein the channel comprises an open channel exposed to an external surface of the micro device.", "4.The fluid flow structure of claim 1, wherein the micro device comprises an electronic device that comprises an electrical terminal, and the structure comprises a conductor connected to the terminal and embedded in the molding.", "5.The fluid flow structure of claim 4, wherein the micro device comprises a printhead die sliver that comprises a fluid manifold connected directly to the fluid port.", "6.The fluid flow structure of claim 5, wherein multiple printhead die slivers are provided, and the monolithic body is molded around the multiple printhead die slivers, the body comprising a tapered channel molded therein through which fluid may flow directly to the slivers.", "7.The fluid flow structure of claim 6, wherein the channel comprises multiple channels through each of which fluid may flow directly to one or more of the slivers.", "8.The fluid flow structure of claim 6, wherein each printhead die sliver comprises a fluid manifold connected directly to a plurality of fluid ports.", "9.The fluid flow structure of claim 8, wherein each printhead die silver comprises a silicon substrate in which the fluid manifold is formed.", "10.A system, comprising: a source of fluid; a fluid dispensing micro device comprising a tapered fluid port to feed fluid to the micro device; and a monolithic molding comprising a tapered channel defined in the molding through which fluid may flow directly into the micro device, the channel being fluidically coupled to the fluid port; and a fluid mover to move fluid from the fluid source to the channel in the fluid flow structure, wherein the micro device is embedded in the molding, wherein the micro device is a printhead die having a thickness less than or equal to 650 μm, and wherein the channel is wider than the fluid port.", "11.The system of claim 10, wherein: the source of fluid comprises a supply of printing fluid; and the fluid mover includes a device to regulate the flow of printing fluid from the supply to the printhead die.", "12.The system of claim 10, wherein the channel is molded into the molding.", "13.The system of claim 10, wherein the channel comprises an open channel exposed to an external surface of the micro device.", "14.The system of claim 10, wherein the micro device comprises an electronic device that comprises an electrical terminal, and the structure comprises a conductor connected to the terminal and embedded in the molding.", "15.The system of claim 14, wherein the micro device comprises a printhead die sliver that comprises a fluid manifold connected directly to the fluid port.", "16.The system of claim 15, wherein multiple printhead die slivers are provided, and the monolithic body is molded around the multiple printhead die slivers, the body comprising a tapered channel molded therein through which fluid may flow directly to the slivers.", "17.The system of claim 16, wherein the channel comprises multiple channels through each of which fluid may flow directly to one or more of the slivers.", "18.system of claim 16, wherein each printhead die sliver comprises a fluid manifold connected directly to a plurality of fluid ports.", "19.The system of claim 18, wherein each printhead die silver comprises a silicon substrate in which the fluid manifold is formed.", "20.The system of claim 10, wherein the micro device comprising: a substrate; an orifice plate coupled to the second side of the substrate; a manifold fluidically coupled to the fluid port; a number of fluid ejection chambers fluidically coupled to the manifold; and a number of orifices defined in the orifice plate and fluidically coupled to the fluid ejection chambers through which fluid is ejected from the micro device." ], [ "<SOH> BACKGROUND <EOH>Each printhead die in an inkjet pen or print bar includes tiny channels that carry ink to the ejection chambers.", "Ink is distributed from the ink supply to the die channels through passages in a structure that supports the printhead die(s) on the pen or print bar.", "It may be desirable to shrink the size of each printhead die, for example to reduce the cost of the die and, accordingly, to reduce the cost of the pen or print bar.", "The use of smaller dies, however, can require changes to the larger structures that support the dies, including the passages that distribute ink to the dies." ], [ "RELATED DOCUMENTS The present application is a continuation and claims the benefit under 35 U.S.C.", "§ 120, of U.S. application Ser.", "No.", "14/769,994, filed Aug. 24, 2015, which claims benefit under 35 U.S.C.", "§ 371 and is the National Stage Entry of International Application No.", "PCT/US2013/028207, filed Feb. 28, 2013.These applications are herein incorporated by reference in their entireties.", "BACKGROUND Each printhead die in an inkjet pen or print bar includes tiny channels that carry ink to the ejection chambers.", "Ink is distributed from the ink supply to the die channels through passages in a structure that supports the printhead die(s) on the pen or print bar.", "It may be desirable to shrink the size of each printhead die, for example to reduce the cost of the die and, accordingly, to reduce the cost of the pen or print bar.", "The use of smaller dies, however, can require changes to the larger structures that support the dies, including the passages that distribute ink to the dies.", "DRAWINGS Each pair of FIGS.", "1/2, 3/4, 5/6, and 7/8 illustrate one example of a new molded fluid flow structure in which a micro device is embedded in a molding with a fluid flow path directly to the device.", "FIG.", "9 is a block diagram illustrating a fluid flow system implementing a new fluid flow structure such as one of the examples shown in FIGS.", "1-8.FIG.", "10 is a block diagram illustrating an inkjet printer implementing one example of a new fluid flow structure for the printheads in a substrate wide print bar.", "FIGS.", "11-16 illustrate an inkjet print bar implementing one example of a new fluid flow structure for a printhead die, such as might be used in the printer of FIG.", "10.FIGS.", "17-21 are section views illustrating one example of a process for making a new printhead die fluid flow structure.", "FIG.", "22 is a flow diagram of the process shown in FIGS.", "17-21.FIGS.", "23-27 are perspective views illustrating one example of a wafer level process for making a new inkjet print bar such as the print bar shown in FIGS.", "11-16.FIG.", "28 is a detail from FIG.", "23.FIGS.", "29-31 illustrate other examples of a new fluid flow structure for a printhead die.", "The same part numbers designate the same or similar parts throughout the figures.", "The figures are not necessarily to scale.", "The relative size of some parts is exaggerated to more clearly illustrate the example shown.", "DESCRIPTION Inkjet printers that utilize a substrate wide print bar assembly have been developed to help increase printing speeds and reduce printing costs.", "Conventional substrate wide print bar assemblies include multiple parts that carry printing fluid from the printing fluid supplies to the small printhead dies from which the printing fluid is ejected on to the paper or other print substrate.", "While reducing the size and spacing of the printhead dies continues to be important for reducing cost, channeling printing fluid from the larger supply components to ever smaller, more tightly spaced dies requires complex flow structures and fabrication processes that can actually increase cost.", "A new fluid flow structure has been developed to enable the use of smaller printhead dies and more compact die circuitry to help reduce cost in substrate wide inkjet printers.", "A print bar implementing one example of the new structure includes multiple printhead dies molded into an elongated, monolithic body of moldable material.", "Printing fluid channels molded into the body carry printing fluid directly to printing fluid flow passages in each die.", "The molding in effect grows the size of each die for making external fluid connections and for attaching the dies to other structures, thus enabling the use of smaller dies.", "The printhead dies and printing fluid channels can be molded at the wafer level to form a new, composite printhead wafer with built-in printing fluid channels, eliminating the need to form the printing fluid channels in a silicon substrate and enabling the use of thinner dies.", "The new fluid flow structure is not limited to print bars or other types of printhead structures for inkjet printing, but may be implemented in other devices and for other fluid flow applications.", "Thus, in one example, the new structure includes a micro device embedded in a molding having a channel or other path for fluid to flow directly into or onto the device.", "The micro device, for example, could be an electronic device, a mechanical device, or a microelectromechanical system (MEMS) device.", "The fluid flow, for example, could be a cooling fluid flow into or onto the micro device or fluid flow into a printhead die or other fluid dispensing micro device.", "These and other examples shown in the figures and described below illustrate but do not limit the invention, which is defined in the Claims following this Description.", "As used in this document, a “micro device” means a device having one or more exterior dimensions less than or equal to 30 mm; “thin” means a thickness less than or equal to 650 μm; a “sliver” means a thin micro device having a ratio of length to width (L/W) of at least three; a “printhead” and a “printhead die” mean that part of an inkjet printer or other inkjet type dispenser that dispenses fluid from one or more openings.", "A printhead includes one or more printhead dies, “Printhead” and “printhead die” are not limited to printing with ink and other printing fluids but also include inkjet type dispensing of other fluids and/or for uses other than printing.", "FIGS.", "1 and 2 are elevation and plan section views, respectively, illustrating one example a new fluid flow structure 10.Referring to FIGS.", "1 and 2, structure 10 includes a micro device 12 molded into in a monolithic body 14 of plastic or other moldable material.", "A molded body 14 is also referred to herein as a molding 14.Micro device 12, for example, could be an electronic device, a mechanical device, or a microelectromechanical system (MEMS) device.", "A channel or other suitable fluid flow path 16 is molded into body 14 in contact with micro device 12 so that fluid in channel 16 can flow directly into or onto device 12 (or both).", "In this example, channel 16 is connected to fluid flow passages 18 in micro device 12 and exposed to exterior surface 20 of micro device 12.In another example, shown in FIGS.", "3 and 4, flow path 16 in molding 14 allows air or other fluid to flow along an exterior surface 20 of micro device 12, for instance to cool device 12.Also, in this example, signal traces or other conductors 22 connected to device 12 at electrical terminals 24 are molded into molding 14.In another example, shown in FIGS.", "5 and 6, micro device 12 is molded into body 14 with an exposed surface 26 opposite channel 16.In another example, shown in FIGS.", "7 and 8, micro devices 12A and 12B are molded into body 14 with fluid flow channels 16A and 16B.", "In this example, flow channels 16A contact the edges of outboard devices 12A while flow channel 16B contacts the bottom of inboard device 12B.", "FIG.", "9 is a block diagram illustrating a system 28 implementing a new fluid flow structure 10 such as one of the flow structures 10 shown in FIGS.", "1-8.Referring to FIG.", "9, system 28 includes a fluid source 30 operatively connected to a fluid mover 32 configured to move fluid to flow path 16 in structure 10.A fluid source 30 might include, for example, the atmosphere as a source of air to cool an electronic micro device 12 or a printing fluid supply for a printhead micro device 12.Fluid mover 32 represents a pump, a fan, gravity or any other suitable mechanism for moving fluid from source 30 to flow structure 10.FIG.", "10 is a block diagram illustrating an inkjet printer 34 implementing one example of a new fluid flow structure 10 in a substrate wide print bar 36.Referring to FIG.", "10, printer 34 includes print bar 36 spanning the width of a print substrate 38, flow regulators 40 associated with print bar 36, a substrate transport mechanism 42, ink or other printing fluid supplies 44, and a printer controller 46.Controller 46 represents the programming, processor(s) and associated memories, and the electronic circuitry and components needed to control the operative elements of a printer 10.Print bar 36 includes an arrangement of printheads 37 for dispensing printing fluid on to a sheet or continuous web of paper or other print substrate 38.As described in detail below, each printhead 37 includes one or more printhead dies in a molding with channels 16 to feed printing fluid directly to the die(s).", "Each printhead die receives printing fluid through a flow path from supplies 44 into and through flow regulators 40 and channels 16 in print bar 36.FIGS.", "11-16 illustrate an inkjet print bar 36 implementing one example of a new fluid flow structure 10, such as might be used in printer 34 shown in FIG.", "10.Referring first to the plan view of FIG.", "11, printheads 37 are embedded in an elongated, monolithic molding 14 and arranged generally end to end in rows 48 in a staggered configuration in which the printheads in each row overlap another printhead in that row.", "Although four rows 48 of staggered printheads 37 are shown, for printing four different colors for example, other suitable configurations are possible.", "FIG.", "12 is a section view taken along the line 12-12 in FIG.", "11.FIGS.", "13-15 are detail views from FIG.", "12, and FIG.", "16 is a plan view diagram showing the layout of some of the features of printhead die flow structure 10 in FIGS.", "12-14.Referring now to FIGS.", "11-15, in the example shown, each printhead 37 includes a pair of printhead dies 12 each with two rows of ejection chambers 50 and corresponding orifices 52 through which printing fluid is ejected from chambers 50.Each channel 16 in molding 14 supplies printing fluid to one printhead die 12.Other suitable configurations for printhead 37 are possible, For example, more or fewer printhead dies 12 may be used with more or fewer ejection chambers 50 and channels 16.", "(Although print bar 36 and printheads 37 face up in FIGS.", "12-15, print bar 36 and printheads 37 usually face down when installed in a printer, as depicted in the block diagram of FIG.", "10.)", "Printing fluid flows into each ejection chamber 50 from a manifold 54 extending lengthwise along each die 12 between the two rows of ejection chambers 50.Printing fluid feeds into manifold 54 through multiple ports 56 that are connected to a printing fluid supply channel 16 at die surface 20.Printing fluid supply channel 16 is substantially wider than printing fluid ports 56, as shown, to carry printing fluid from larger, loosely spaced passages in the flow regulator or other parts that carry printing fluid into print bar 36 to the smaller, tightly spaced printing fluid ports 56 in printhead die 12.Thus, printing fluid supply channels 16 can help reduce or even eliminate the need for a discrete “fan-out” and other fluid routing structures necessary in some conventional printheads.", "In addition, exposing a substantial area of printhead die surface 20 directly to channel 16, as shown, allows printing fluid in channel 16 to help cool die 12 during printing.", "The idealized representation of a printhead die 12 in FIGS.", "11-15 depicts three layers 58, 60, 62 for convenience only to clearly show ejection chambers 50, orifices 52, manifold 54, and ports 56.An actual inkjet printhead die 12 is a typically complex integrated circuit (IC) structure formed on a silicon substrate 58 with layers and elements not shown in FIGS.", "11-15.For example, a thermal ejector element or a piezoelectric ejector element formed on substrate 58 at each ejection chamber 50 is actuated to eject drops or streams of ink or other printing fluid from orifices 52.A molded flow structure 10 enables the use of long, narrow and very thin printhead dies 12.For example, it has been shown that a 100 μm thick printhead die 12 that is about 26 mm long and 500 μm wide can be molded into a 500 μm thick body 14 to replace a conventional 500 μm thick silicon printhead die.", "Not only is it cheaper and easier to mold channels 16 into body 14 compared to forming the feed channels in a silicon substrate, but it is also cheaper and easier to form printing fluid ports 56 in a thinner die 12.For example, ports 56 in a 100 μm thick printhead die 12 may be formed by dry etching and other suitable micromachining techniques not practical for thicker substrates.", "Micromachining a high density array of straight or slightly tapered through ports 56 in a thin silicon, glass or other substrate 58 rather than forming conventional slots leaves a stronger substrate while still providing adequate printing fluid flow.", "Tapered ports 56 help move air bubbles away from manifold 54 and ejection chambers 50 formed, for example, in a monolithic or multi-layered orifice plate 60/62 applied to substrate 58.It is expected that current die handling equipment and micro device molding tools and techniques can be adapted to mold dies 12 as thin as 50 μm, with a length/width ratio up to 150, and to mold channels 16 as narrow as 30 μm.", "And, the molding 14 provides an effective but inexpensive structure in which multiple rows of such die slivers can be supported in a single, monolithic body.", "FIGS.", "17-21 illustrate one example process for making a new printhead fluid flow structure 10.FIG.", "22 is a flow diagram of the process illustrated in FIGS.", "17-21.Referring first to FIG.", "17, a flex circuit 64 with conductive traces 22 and protective layer 66 is laminated on to a carrier 68 with a thermal release tape 70, or otherwise applied to carrier 68 (step 102 in FIG.", "22).", "As shown in FIGS.", "18 and 19, printhead die 12 is placed orifice side down in opening 72 on carrier 68 (step 104 in FIG.", "22) and conductor 22 is bonded to an electrical terminal 24 on die 12 (step 106 in FIG.", "22).", "In FIG.", "20, a molding tool 74 forms channel 16 in a molding 14 around printhead die 12 (step 108 in FIG.", "22).", "A tapered channel 16 may be desirable in some applications to facilitate the release of molding tool 74 or to increase fan-out (or both).", "After molding, printhead flow structure 10 is released from carrier 68 (step 110 in FIG.", "22) to form the completed part shown in FIG.", "21 in which conductor 22 is covered by layer 66 and surrounded by molding 14.In a transfer molding process such as that shown in FIG.", "20, channels 16 are molded into body 14.In other fabrication processes, it may be desirable to form channels 16 after molding body 14 around printhead die 12.While the molding of a single printhead die 12 and channel 16 is shown in FIGS.", "17-21, multiple printhead dies and printing fluid channels can be molded simultaneously at the wafer level.", "FIGS.", "23-28 illustrate one example wafer level process for making print bars 36.Referring to FIG.", "23, printheads 37 are placed on a glass or other suitable carrier wafer 68 in a pattern of multiple print bars.", "(Although a “wafer” is sometimes used to denote a round substrate while a “panel” is used to denote a rectangular substrate, a “wafer” as used in this document includes any shape substrate.)", "Printheads 37 usually will be placed on to carrier 68 after first applying or forming a pattern of conductors 22 and die openings 72 as described above with reference to FIG.", "17 and step 102 in FIG.", "22.In the example shown in FIG.", "23, five sets of dies 78 each having four rows of printheads 37 are laid out on carrier wafer 66 to form five print bars.", "A substrate wide print bar for printing on Letter or A4 size substrates with four rows of printheads 37, for example, is about 230 mm long and 16 mm wide.", "Thus, five die sets 78 may be laid out on a single 270 mm×90 mm carrier wafer 66 as shown in FIG.", "23.Again, in the example shown, an array of conductors 22 extend to bond pads 23 near the edge of each row of printheads 37.Conductors 22 and bond pads 23 are more clearly visible in the detail of FIG.", "28.", "(Conductive signal traces to individual ejection chambers or groups of ejection chambers, such as conductors 22 in FIG.", "21, are omitted to not obscure other structural features.)", "FIG.", "24 is a close-up section view of one set of four rows of printheads 37 taken along the line 24-24 in FIG.", "23.Cross hatching is omitted for clarity.", "FIGS.", "23 and 24 show the in-process wafer structure after the completion of steps 102-112 in FIG.", "23.FIG.", "25 shows the section of FIG.", "24 after molding step 114 in FIG.", "23 in which body 14 with channels 16 is molded around printhead dies 12.Individual print bar strips 78 are separated in FIG.", "26 and released from carrier 68 in FIG.", "27 to form five individual print bars 36 (step 116 in FIG.", "23).", "While any suitable molding technology may be used, testing suggests that wafer level molding tools and techniques currently used for semiconductor device packaging may be adapted cost effectively to the fabrication of printhead die fluid flow structures 10 such as those shown in FIGS.", "21 and 27.A stiffer molding 14 may be used where a rigid (or at least less flexible) print bar 36 is desired to hold printhead dies 12.A less stiff molding 14 may be used where a flexible print bar 36 is desired, for example where another support structure holds the print bar rigidly in a single plane or where a non-planar print bar configuration is desired.", "Also, although it is expected that molded body 14 usually will be molded as a monolithic part, body 14 could be molded as more than one part.", "FIGS.", "29-31 illustrate other examples of a new fluid flow structure 10 for a printhead die 12.In these examples, channels 16 are molded in body 14 along each side of printhead die 12, for example using a transfer molding process such as that described above with reference to FIGS.", "17-21.Printing fluid flows from channels 16 through ports 56 laterally into each ejection chamber 50 directly from channels 16.In the example of FIG.", "30, orifice plate 62 is applied after molding body 14 to close channels 16.In the example of FIG.", "31, a cover 80 is formed over orifice plate 62 to close channels 16.Although a discrete cover 80 partially defining channels 16 is shown, an integrated cover 80 molded into body 14 could also be used.", "As noted at the beginning of this Description, the examples shown in the figures and described above illustrate but do not limit the invention.", "Other examples are possible.", "Therefore, the foregoing description should not be construed to limit the scope of the invention, which is defined in the following claims." ] ]
Patent_15872635
[ [ "METHODS, SYSTEMS, AND DEVICES FOR CONTROL OF SURGICAL TOOLS IN A ROBOTIC SURGICAL SYSTEM", "Techniques for a surgical system are provided that allow controlling a force applied by an electromechanical surgical tool coupled to an electromechanical surgical arm.", "A force limiter can be associated with at least one of the surgical arm and the tool and is used to limit the force applied by jaws of the tool to tissue when the tissue is engaged therebetween or when the tissue is otherwise manipulated.", "The force can be limited to a maximum force value, which can be preselected, and it can be adjustable based on user input or automatically.", "Also are provided techniques for a surgical system that allow controlling a stiffness of an electromechanical passive arm coupled to a fixture and having an active arm mounted thereon.", "The stiffness is adjusted, either manually or automatically, by adjusting a friction at a joint of the arm based on an angle at the arm's joint." ], [ "1.A surgical system, comprising: a passive arm having a first end configured to be coupled to a fixture and a second end, the passive arm having first and second passive arm segments extending between the first and second ends, and the passive arm having a joint between the first and second passive arm segments, the second end being configured to move toward and away from the fixture such that an angle between the first and second arm segments increases as a distance between the second end and the fixture increases; and an active arm coupled to the second end of the passive arm and configured to have a surgical instrument coupled to a distal end thereof, wherein the joint connecting first and second passive arm segments has a stiffness that is controlled based on the angle between the first and second arm segments of the passive arm.", "2.The surgical system of claim 1, wherein the stiffness is configured to decrease as the angle between the first and second arm segments of the passive arm increases.", "3.The surgical system of claim 1, wherein the stiffness of the joint is automatically adjustable based on the angle.", "4.The surgical system of claim 1, wherein the stiffness of the joint is selectively controllable based on user input.", "5.The surgical system of claim 1, wherein the stiffness of the joint is automatically adjustable via a software-based controller.", "6.The surgical system of claim 1, wherein the joint has an angle measurement sensor coupled thereto and configured to measure the angle.", "7.The surgical system of claim 3, wherein the joint has a force sensor coupled thereto and configured to sense a force applied to the passive arm.", "8.The surgical system of claim 1, wherein the joint includes a clutch mechanism.", "9.The surgical system of claim 1, wherein the system is configured to: in response to detecting that a force is being applied to the joint to position the passive arm and thereby change the angle between the first and second passive arm segments, reduce a resistance of the joint to allow the passive arm to be repositioned to an other position; and after the passive arm is repositioned, and in response to detecting that the force is no longer being applied to the joint, increase the resistance of the joint to cause the joint to remain in the other position.", "10.The surgical system of claim 9, wherein the resistance of the joint is increased to cause the joint to remain in the other position such that the passive arm is precluded from being moved without a further force applied thereto.", "11.The surgical system of claim 1, wherein the stiffness of the joint is controlled proportionally to the angle between the first and second passive arm segments.", "12.The surgical system of claim 1, wherein the system is configured to: in response to detecting that a force is being applied to the joint to position the passive arm and thereby change the angle between the first and second passive arm segments, increase a stiffness as the angle increases from about 0 degrees to about 90 degrees and decrease the stiffness as the angle further increases to become greater than 90 degrees.", "13.The surgical system of claim 1, wherein the stiffness is controlled such that the second end is configured to move toward and away from the fixture irrespective of a load applied to the passive arm.", "14.The surgical system of claim 1, wherein, at a locked configuration, the stiffness of the joint is greater than a gravitational force and a load applied to the passive arm.", "15.A method of operating a surgical system, the method comprising: positioning an electromechanical surgical arm comprising a passive arm and an active arm coupled to the passive arm, the active arm having a surgical instrument coupled to a distal end thereof, and the passive arm having first and second arm segments and a joint connecting the first and second arm segments, wherein the first arm segment has a first end coupled to a fixture and a second end coupled to the active arm; and changing a position of the passive arm by moving the second arm segment such that an angle between the first and second arm segments increases as a distance between the second end and the fixture increases, and such that a stiffness of the joint is controlled based on the angle.", "16.The method of claim 15, wherein the stiffness of the joint is configured to decrease as the angle between the first and second arm segments increases.", "17.The method of claim 15, wherein the stiffness of the joint is automatically adjusted based on the angle.", "18.The method of claim 15, wherein the stiffness of the joint is selectively adjusted based on user input.", "19.The method of claim 15, wherein the stiffness of the joint is automatically adjustable via a software-based controller.", "20.The method of claim 15, further comprising receiving sensor data from a force sensor associated with the joint thereto and configured to sense a force applied to the passive arm, wherein the surgical system is configured to adjust the stiffness of the joint at least partially based on the received sensor data." ], [ "<SOH> BACKGROUND <EOH>Minimally invasive surgical (MIS) instruments are often preferred over traditional open surgical devices due to the reduced post-operative recovery time and minimal scarring.", "Laparoscopic surgery is one type of MIS procedure in which one or more small incisions are formed in the abdomen and a trocar is inserted through the incision to form a pathway that provides access to the abdominal cavity.", "The trocar is used to introduce various instruments and tools into the abdominal cavity, as well as to provide insufflation to elevate the abdominal wall above the organs.", "The instruments and tools can be used to engage and/or treat tissue in a number of ways to achieve a diagnostic or therapeutic effect.", "Endoscopic surgery is another type of MIS procedure in which elongate flexible shafts are introduced into the body through a natural orifice.", "Various robotic systems have been developed to assist in MIS procedures.", "Robotic systems can allow for more intuitive hand movements by maintaining both natural eye-hand axis.", "Robotic systems can also allow for more degrees of freedom in movement by including a “wrist” joint on the instrument, creating a more natural hand-like articulation.", "One drawback with robotic systems, however, is the loss of direct human contact with the tissue.", "It can be very difficult and expensive to give true force feedback to the surgeon.", "Another drawback is that robotic systems traditionally only allow the surgeon to control movement of up to two surgical instruments, with any other surgical instruments having to be manually controlled by other medical personnel.", "It can be difficult for the surgeon and other medical personnel to communicate and synchronize activities of the separately controlled instruments during performance of a surgical procedure.", "Accordingly, there remains a need for improved methods, systems, and devices for control of surgical tools in a robotic surgical system." ], [ "<SOH> SUMMARY <EOH>In one aspect, a surgical system is provided that in some embodiments includes an electromechanical arm configured for movement in multiple axes, an electromechanical tool mounted on the electromechanical arm, and a force limiter associated with at least one of the electromechanical arm and the electromechanical tool and configured to limit a force applied by at least one of the electromechanical arm and the electromechanical tool to cause movement of the electromechanical tool, the force being limited to a threshold force value.", "The threshold force value can be selected in a number of ways and it can be any suitable value.", "For example, the threshold force value can be selected based on a user input.", "For another example, the threshold force value can be selected automatically.", "The threshold force value can be a maximum force value.", "The maximum force value can be adjustable via a user input system.", "As another example, the maximum force value can be adjustable via a force limiter associated with the electromechanical tool.", "The force limiter can vary in a number of ways.", "For example, the force limiter can be or can include at least one mechanical component.", "The at least one mechanical component can be a slip clutch associated with the electromechanical tool.", "The force limiter can further include a force limiter adjustment mechanism.", "The at least one mechanical component can include a slip clutch coupled to first and second jaws of the electromechanical tool, and the force limiter adjustment mechanism can include at least one shim or at least one bellow disposed between the first and second jaws.", "In some embodiments, the force limiter can include at least one motor, and wherein current controlling torque of the at least one motor is used to control and limit the force applied by the electromechanical arm.", "In other aspects, a method of operating a surgical system is provided that in some embodiments includes positioning an electromechanical arm of the surgical system in proximity to a patient's body, and manipulating an electromechanical tool mounted on the electromechanical arm to perform a surgical function, wherein a force applied by at least one of the electromechanical arm and the electromechanical tool to cause movement of the electromechanical tool is limited to a maximum force by a force limiter associated with at least one of the electromechanical arm and the electromechanical tool.", "The method can vary in a number of ways.", "For example, the method can include receiving an input indicating a value of the maximum force.", "The input can vary in a number of ways a user input received via a user interface of a computing device.", "In other aspects, a surgical system is provided that in some embodiments includes a passive arm having a first end configured to be coupled to a fixture and a second end, the passive arm having a joint between the first and second ends connecting first and second passive arm segments, the second end being configured to move toward and away from the fixture such that an angle between the first and second arm segments increases as a distance between the second end and the fixture increases, and an active arm coupled to the second end of the passive arm.", "The joint has a stiffness that is configured to proportionally decrease as the angle increases.", "The surgical system can vary in a number of ways.", "For example, the stiffness of the joint can be automatically adjusted based on the angle.", "In at least some embodiments, the stiffness of the joint can be selectively controllable based on user input.", "In at least some embodiments, the stiffness of the joint can be automatically adjustable via a software-based controller.", "The joint can also vary in a number of ways.", "For example, the joint can have an angle measurement sensor coupled thereto and configured to measure the angle.", "Additionally or alternatively, the joint can have a force sensor coupled thereto and configured to sense a force applied to the passive arm.", "In at least some embodiments, the joint can include a clutch mechanism.", "In some embodiments, the system is configured to in response to detecting that a force is being applied to the joint to position the passive arm and thereby change the angle between the first and second arm segments, reduce a resistance of the joint to allow the passive arm to be repositioned to an other position; and after the passive arm is repositioned, and in response to detecting that the force is no longer being applied to the joint, increase the resistance of the joint to cause the joint to remain in the other position.", "In further aspects, a method of operating a surgical system is provided that in some embodiments includes positioning an electromechanical surgical arm comprising a passive arm and an active arm coupled to the passive arm, the passive arm having first and second arm segments and a joint connecting the arm segments in proximity to a patient's body, wherein the first arm segment has a first end coupled to a fixture and a second end coupled to the active arm.", "The method further includes changing a position of the passive arm by moving the second arm segment such that an angle between the first and second arm segments increases as a distance between the second end and the fixture increases, and such that a stiffness of the joint proportionally decreases as the angle increases.", "Non-transitory computer program products (i.e., physically embodied computer program products) are also provided that store instructions, which when executed by one or more processors of one or more computer systems, causes at least one processor to perform operations herein.", "Similarly, computer systems are also provided that can include one or more processors and one or more memories coupled to the one or more processors.", "Each of the one or more memories can temporarily or permanently store instructions that cause at least one processor to perform one or more of the operations described herein.", "In addition, methods can be implemented by one or more processors either within a single computer system or distributed among two or more computer systems.", "Such computer systems can be connected and can exchange data and/or commands or other instructions or the like via one or more connections, including but not limited to a connection over a network (e.g., the Internet, a wireless wide area network, a local area network, a wide area network, a wired network, etc.", "), via a direct connection between one or more of the multiple computer systems, etc." ], [ "CROSS REFERENCE The present application is a continuation of U.S. patent application Ser.", "No.", "14/959,262 filed Dec. 4, 2015 and entitled “Methods, Systems, and Devices for Control of Surgical Tools in a Robotic Surgical System,” which is hereby incorporated by reference in its entirety herein.", "FIELD The present disclosure relates generally to methods, systems, and devices for control of surgical tools in a robotic surgical system.", "BACKGROUND Minimally invasive surgical (MIS) instruments are often preferred over traditional open surgical devices due to the reduced post-operative recovery time and minimal scarring.", "Laparoscopic surgery is one type of MIS procedure in which one or more small incisions are formed in the abdomen and a trocar is inserted through the incision to form a pathway that provides access to the abdominal cavity.", "The trocar is used to introduce various instruments and tools into the abdominal cavity, as well as to provide insufflation to elevate the abdominal wall above the organs.", "The instruments and tools can be used to engage and/or treat tissue in a number of ways to achieve a diagnostic or therapeutic effect.", "Endoscopic surgery is another type of MIS procedure in which elongate flexible shafts are introduced into the body through a natural orifice.", "Various robotic systems have been developed to assist in MIS procedures.", "Robotic systems can allow for more intuitive hand movements by maintaining both natural eye-hand axis.", "Robotic systems can also allow for more degrees of freedom in movement by including a “wrist” joint on the instrument, creating a more natural hand-like articulation.", "One drawback with robotic systems, however, is the loss of direct human contact with the tissue.", "It can be very difficult and expensive to give true force feedback to the surgeon.", "Another drawback is that robotic systems traditionally only allow the surgeon to control movement of up to two surgical instruments, with any other surgical instruments having to be manually controlled by other medical personnel.", "It can be difficult for the surgeon and other medical personnel to communicate and synchronize activities of the separately controlled instruments during performance of a surgical procedure.", "Accordingly, there remains a need for improved methods, systems, and devices for control of surgical tools in a robotic surgical system.", "SUMMARY In one aspect, a surgical system is provided that in some embodiments includes an electromechanical arm configured for movement in multiple axes, an electromechanical tool mounted on the electromechanical arm, and a force limiter associated with at least one of the electromechanical arm and the electromechanical tool and configured to limit a force applied by at least one of the electromechanical arm and the electromechanical tool to cause movement of the electromechanical tool, the force being limited to a threshold force value.", "The threshold force value can be selected in a number of ways and it can be any suitable value.", "For example, the threshold force value can be selected based on a user input.", "For another example, the threshold force value can be selected automatically.", "The threshold force value can be a maximum force value.", "The maximum force value can be adjustable via a user input system.", "As another example, the maximum force value can be adjustable via a force limiter associated with the electromechanical tool.", "The force limiter can vary in a number of ways.", "For example, the force limiter can be or can include at least one mechanical component.", "The at least one mechanical component can be a slip clutch associated with the electromechanical tool.", "The force limiter can further include a force limiter adjustment mechanism.", "The at least one mechanical component can include a slip clutch coupled to first and second jaws of the electromechanical tool, and the force limiter adjustment mechanism can include at least one shim or at least one bellow disposed between the first and second jaws.", "In some embodiments, the force limiter can include at least one motor, and wherein current controlling torque of the at least one motor is used to control and limit the force applied by the electromechanical arm.", "In other aspects, a method of operating a surgical system is provided that in some embodiments includes positioning an electromechanical arm of the surgical system in proximity to a patient's body, and manipulating an electromechanical tool mounted on the electromechanical arm to perform a surgical function, wherein a force applied by at least one of the electromechanical arm and the electromechanical tool to cause movement of the electromechanical tool is limited to a maximum force by a force limiter associated with at least one of the electromechanical arm and the electromechanical tool.", "The method can vary in a number of ways.", "For example, the method can include receiving an input indicating a value of the maximum force.", "The input can vary in a number of ways a user input received via a user interface of a computing device.", "In other aspects, a surgical system is provided that in some embodiments includes a passive arm having a first end configured to be coupled to a fixture and a second end, the passive arm having a joint between the first and second ends connecting first and second passive arm segments, the second end being configured to move toward and away from the fixture such that an angle between the first and second arm segments increases as a distance between the second end and the fixture increases, and an active arm coupled to the second end of the passive arm.", "The joint has a stiffness that is configured to proportionally decrease as the angle increases.", "The surgical system can vary in a number of ways.", "For example, the stiffness of the joint can be automatically adjusted based on the angle.", "In at least some embodiments, the stiffness of the joint can be selectively controllable based on user input.", "In at least some embodiments, the stiffness of the joint can be automatically adjustable via a software-based controller.", "The joint can also vary in a number of ways.", "For example, the joint can have an angle measurement sensor coupled thereto and configured to measure the angle.", "Additionally or alternatively, the joint can have a force sensor coupled thereto and configured to sense a force applied to the passive arm.", "In at least some embodiments, the joint can include a clutch mechanism.", "In some embodiments, the system is configured to in response to detecting that a force is being applied to the joint to position the passive arm and thereby change the angle between the first and second arm segments, reduce a resistance of the joint to allow the passive arm to be repositioned to an other position; and after the passive arm is repositioned, and in response to detecting that the force is no longer being applied to the joint, increase the resistance of the joint to cause the joint to remain in the other position.", "In further aspects, a method of operating a surgical system is provided that in some embodiments includes positioning an electromechanical surgical arm comprising a passive arm and an active arm coupled to the passive arm, the passive arm having first and second arm segments and a joint connecting the arm segments in proximity to a patient's body, wherein the first arm segment has a first end coupled to a fixture and a second end coupled to the active arm.", "The method further includes changing a position of the passive arm by moving the second arm segment such that an angle between the first and second arm segments increases as a distance between the second end and the fixture increases, and such that a stiffness of the joint proportionally decreases as the angle increases.", "Non-transitory computer program products (i.e., physically embodied computer program products) are also provided that store instructions, which when executed by one or more processors of one or more computer systems, causes at least one processor to perform operations herein.", "Similarly, computer systems are also provided that can include one or more processors and one or more memories coupled to the one or more processors.", "Each of the one or more memories can temporarily or permanently store instructions that cause at least one processor to perform one or more of the operations described herein.", "In addition, methods can be implemented by one or more processors either within a single computer system or distributed among two or more computer systems.", "Such computer systems can be connected and can exchange data and/or commands or other instructions or the like via one or more connections, including but not limited to a connection over a network (e.g., the Internet, a wireless wide area network, a local area network, a wide area network, a wired network, etc.", "), via a direct connection between one or more of the multiple computer systems, etc.", "BRIEF DESCRIPTION OF DRAWINGS This disclosure will be more fully understood from the following detailed description taken in conjunction with the accompanying drawings, in which: FIG.", "1 is a graphical representation of terminology associated with six degrees of freedom; FIG.", "2 is a schematic view of one embodiment of a computer system; FIG.", "3 is a schematic view of one embodiment of a robotic surgical system configured to be operated by a user and to be used during performance of a surgical procedure on a patient; FIG.", "4 is a perspective view of one embodiment of an arm of a robotic surgical system, the arm being mounted to a surgical table; FIG.", "5 is a perspective view of an active portion of the arm of FIG.", "4; FIG.", "6 is a perspective view of one embodiment of a robotic surgical system; FIG.", "7 is a schematic view of one embodiment of the robotic surgical system of FIG.", "6 in use during performance of a surgical procedure on a patient; FIG.", "8 is a perspective view of the robotic surgical system of FIG.", "7 in use during performance of the surgical procedure on a patient; FIG.", "9 is a schematic and perspective view of another embodiment of a robotic surgical system; FIG.", "10 is a perspective view of one embodiment of a master tool in a field generated by a transmitter of the robotic surgical system of FIG.", "9; FIG.", "11 is a perspective view of one embodiment of an electromechanical tool of a surgical instrument; FIG.", "12A is a cross-sectional view of a portion of the electromechanical tool of FIG.", "11 which can have a force limiter associated therewith; FIG.", "12B is a cross-sectional view of a portion of the electromechanical tool of FIG.", "11 which can have a force limiter associated therewith, additionally showing a spring; FIG.", "13A is a cross-sectional view of one embodiment of a portion of an electromechanical tool having a force limiter associated therewith; FIG.", "13B is an enlarged cross-sectional view of the portion of the electromechanical tool of FIG.", "13A, illustrating the force limiter; FIG.", "14 is an enlarged cross-sectional view of another embodiment of a portion of an electromechanical tool having a force limiter associated therewith; FIG.", "15 is a perspective cross-sectional view of one embodiment of a portion of an electromechanical tool having a force limiter in the form of spacer shims associated therewith; FIG.", "16 is a perspective cross-sectional view of one embodiment of a portion of an electromechanical tool having a force limiter in the form of bellows associated therewith; FIG.", "17 is a schematic diagram illustrating a force limiter implemented in software; FIG.", "18 is a flowchart illustrating an example of a process of selecting a threshold force value for a force limiter of a tool of a surgical instrument in accordance with some embodiments; FIG.", "19 is a perspective view of a robotic surgical system in which a stiffness of an electromechanical passive arm is controlled in accordance with some embodiments; FIG.", "20 is a schematic diagram of a clutch; FIG.", "21 is a perspective view of a robotic surgical system in which a stiffness of a passive arm is controlled in accordance with some embodiments; FIG.", "22 is a flowchart illustrating an example of a process of setting or adjusting a stiffness of a passive arm; FIG.", "23 is a perspective view of one embodiment of a portion of an electromechanical arm of a surgical system which has a force limiter associated therewith; and FIG.", "24 is a perspective view of the force limiter associated with the electromechanical arm of FIG.", "23.DETAILED DESCRIPTION Certain exemplary embodiments will now be described to provide an overall understanding of the principles of the structure, function, manufacture, and use of the devices and methods disclosed herein.", "One or more examples of these embodiments are illustrated in the accompanying drawings.", "Those skilled in the art will understand that the devices and methods specifically described herein and illustrated in the accompanying drawings are non-limiting exemplary embodiments and that the scope of the present invention is defined solely by the claims.", "The features illustrated or described in connection with one exemplary embodiment may be combined with the features of other embodiments.", "Such modifications and variations are intended to be included within the scope of the present disclosure.", "Further, in the present disclosure, like-named components of the embodiments generally have similar features, and thus within a particular embodiment each feature of each like-named component is not necessarily fully elaborated upon.", "Additionally, to the extent that linear or circular dimensions are used in the description of the disclosed systems, devices, and methods, such dimensions are not intended to limit the types of shapes that can be used in conjunction with such systems, devices, and methods.", "A person skilled in the art will recognize that an equivalent to such linear and circular dimensions can easily be determined for any geometric shape.", "Sizes and shapes of the systems and devices, and the components thereof, can depend at least on the anatomy of the subject in which the systems and devices will be used, the size and shape of components with which the systems and devices will be used, and the methods and procedures in which the systems and devices will be used.", "The present disclosure provides techniques for limiting a force applied by one or both of an electromechanical arm and an electromechanical tool coupled thereto of a robotic surgical system.", "The force is limited to avoid unintentional trauma to tissue as it is manipulated by the tool.", "Conventional surgical instruments having a tool, such as a tissue grasper, stapler, or other tissue-manipulating tool coupled thereto, allow only a manual control over a strength with which the tool engages the tissue.", "Thus, if a less experienced surgeon is using an instrument, the tissue can be pulled and/or squeezed too hard, which can cause its damage and can break a suture being used.", "Accordingly, force limiting techniques are provided that allow control over the force applied by the tool and/or arm.", "The force limiting techniques can be implemented using various force limiters, which can be or can include force limiting mechanisms and/or software-based force limiters.", "The present disclosure also provides techniques for controlling stiffness of an electromechanical arm of a robotic surgical system.", "The electromechanical arm can be a passive arm mounted on an operating table or other platform and having an active arm coupled thereto.", "The passive arm needs to be positioned in a desired manner with respect to a patient laid on the operating table, to thereby properly position the active arm which has a surgical tool suitable for performing the surgical procedure coupled thereto.", "The passive arm's position may need to be changed during the surgery.", "However, the weight of the passive arm, as well as the weight of components mounted thereon, can complicate adjustment of the arm's position.", "Also, a precision of the positioning can be affected by the properties of the arm's joints.", "The described techniques provide a way to facilitate positioning of the arm, by controlling a friction of the arm's joint(s) to thereby control arm's stiffness.", "The arm's stiffness can be controlled such that, when a user moves the arm, the friction at the arm's joint changes accordingly, to thus facilitate user's manipulation of the arm.", "Terminology There are a number of ways in which to describe the movement of a surgical system, as well as its position and orientation in space.", "One particularly convenient convention is to characterize a system in terms of its degrees of freedom.", "The degrees of freedom of a system are the number of independent variables that uniquely identify its pose or configuration.", "The set of Cartesian degrees of freedom is usually represented by the three translational or position variables, e.g., surge, heave, sway, and by the three rotational or orientation variables, e.g., Euler angles or roll, pitch, yaw, that describe the position and orientation of a component of a surgical system with respect to a given reference Cartesian frame.", "As used herein, and as illustrated in FIG.", "1, the term “surge” refers to forward and backward movement, the term “heave” refers to movement up and down, and the term “sway” refers to movement left and right.", "With regard to the rotational terms, “roll” refers to tilting side to side, “pitch” refers to tilting forward and backward, and “yaw” refers to turning left and right.", "In a more general sense, each of the translation terms refers to movement along one of the three axes in a Cartesian frame, and each of the rotational terms refers to rotation about one of the three axes in a Cartesian frame.", "Although the number of degrees of freedom is at most six, a condition in which all the translational and orientational variables are independently controlled, the number of joint degrees of freedom is generally the result of design choices that involve considerations of the complexity of the mechanism and the task specifications.", "For non-redundant kinematic chains, the number of independently controlled joints is equal to the degree of mobility for an end effector.", "For redundant kinematic chains, the end effector will have an equal number of degrees of freedom in Cartesian space that will correspond to a combination of translational and rotational motions.", "Accordingly, the number of degrees of freedom can be more than, equal to, or less than six.", "With regard to characterizing the position of various components of the surgical system and the mechanical frame, the terms “forward” and “rearward” may be used.", "In general, the term “forward” refers to an end of the surgical system that is closest to the distal end of the input tool, and when in use in a surgical procedure, to the end disposed within a patient's body.", "The term “rearward” refers to an end of the surgical system farthest from the distal end of the input tool, and when in use, generally to the end farther from the patient.", "The terminology used herein is not intended to limit the invention.", "For example, spatially relative terms, e.g., “superior,” “inferior,” “beneath,” “below,” “lower,” “above,” “upper,” “rearward,” “forward,” etc., may be used to describe one element's or feature's relationship to another element or feature as illustrated in the figures.", "These spatially relative terms are intended to encompass different positions and orientations of the device in use or operation in addition to the position and orientation shown in the figures.", "For example, if the device in the figures is turned over, elements described as “inferior to” or “below” other elements or features would then be “superior to” or “above” the other elements or features.", "Likewise, descriptions of movement along and around various axes includes various special device positions and orientations.", "As will be appreciated by those skilled in the art, specification of the presence of stated features, steps, operations, elements, and/or components does not preclude the presence or addition of one or more other features, steps, operations, elements, components, and/or groups described herein.", "In addition, components described as coupled may be directly coupled, or they may be indirectly coupled via one or more intermediate components.", "There are several general aspects that apply to the various descriptions below.", "For example, at least one surgical end effector is shown and described in various figures.", "An end effector is the part of a minimally invasive or invasive surgical instrument or assembly that performs a specific surgical function, e.g., forceps/graspers, needle drivers, scissors, electrocautery hooks, staplers, clip appliers/removers, suction tools, irrigation tools, etc.", "Any end effector can be utilized with the surgical system described herein.", "Further, in exemplary embodiments, an end effector can be configured to be manipulated by a user input tool.", "The input tool can be any tool that allows successful manipulation of the end effector, whether it be a tool similar in shape and style to the end effector, such as an input tool of scissors similar to end effector scissors, or a tool that is different in shape and style to the end effector, such as an input tool of a glove dissimilar to end effector graspers, and such as input tool of a joystick dissimilar to end effector graspers.", "In some embodiments, the input tool can be a larger scaled version of the end effector to facilitate ease of use.", "Such a larger scale input tool can have finger loops or grips of a size suitable for a user to hold.", "However, the end effector and the input tool can have any relative size.", "A slave tool, e.g., a surgical instrument, of the surgical system can be positioned inside a patient's body cavity through an access point in a tissue surface for minimally invasive surgical procedures.", "Typically, cannulas such as trocars are used to provide a pathway through a tissue surface and/or to prevent a surgical instrument or guide tube from rubbing on patient tissue.", "Cannulas can be used for both incisions and natural orifices.", "Some surgical procedures require insufflation, and the cannula can include one or more seals to prevent excess insufflation gas leakage past the instrument or guide tube.", "In some embodiments, the cannula can have a housing coupled thereto with two or more sealed ports for receiving various types of instruments besides the slave assembly.", "As will be appreciated by a person skilled in the art, any of the surgical system components disclosed herein can have a functional seal disposed thereon, therein, and/or therearound to prevent and/or reduce insufflation leakage while any portion of the surgical system is disposed through a surgical access port, such as a cannula.", "The surgical system can also be used in open surgical procedures.", "As used herein, a surgical access point is a point at which the slave tool enters a body cavity through a tissue surface, whether through a cannula in a minimally invasive procedure or through an incision in an open procedure.", "Computer Systems The systems, devices, and methods disclosed herein can be implemented using one or more computer systems, which may also be referred to herein as digital data processing systems and programmable systems.", "One or more aspects or features of the subject matter described herein can be realized in digital electronic circuitry, integrated circuitry, specially designed application specific integrated circuits (ASICs), field programmable gate arrays (FPGAs) computer hardware, firmware, software, and/or combinations thereof.", "These various aspects or features can include implementation in one or more computer programs that are executable and/or interpretable on a programmable system including at least one programmable processor, which can be special or general purpose, coupled to receive data and instructions from, and to transmit data and instructions to, a storage system, at least one input device, and at least one output device.", "The programmable system or computer system may include clients and servers.", "A client and server are generally remote from each other and typically interact through a communication network.", "The relationship of client and server arises by virtue of computer programs running on the respective computers and having a client-server relationship to each other.", "The computer programs, which can also be referred to as programs, software, software applications, applications, components, or code, include machine instructions for a programmable processor, and can be implemented in a high-level procedural language, an object-oriented programming language, a functional programming language, a logical programming language, and/or in assembly/machine language.", "As used herein, the term “machine-readable medium” refers to any computer program product, apparatus and/or device, such as for example magnetic discs, optical disks, memory, and Programmable Logic Devices (PLDs), used to provide machine instructions and/or data to a programmable processor, including a machine-readable medium that receives machine instructions as a machine-readable signal.", "The term “machine-readable signal” refers to any signal used to provide machine instructions and/or data to a programmable processor.", "The machine-readable medium can store such machine instructions non-transitorily, such as for example as would a non-transient solid-state memory or a magnetic hard drive or any equivalent storage medium.", "The machine-readable medium can alternatively or additionally store such machine instructions in a transient manner, such as for example as would a processor cache or other random access memory associated with one or more physical processor cores.", "To provide for interaction with a user, one or more aspects or features of the subject matter described herein can be implemented on a computer having a display device, such as for example a cathode ray tube (CRT) or a liquid crystal display (LCD) or a light emitting diode (LED) monitor for displaying information to the user and a keyboard and a pointing device, e.g., a mouse, a trackball, etc., by which the user may provide input to the computer.", "Other kinds of devices can be used to provide for interaction with a user as well.", "For example, feedback provided to the user can be any form of sensory feedback, such as for example visual feedback, auditory feedback, or tactile feedback; and input from the user may be received in any form, including, but not limited to, acoustic, speech, or tactile input.", "Other possible input devices include, but are not limited to, touch screens or other touch-sensitive devices such as single or multi-point resistive or capacitive trackpads, voice recognition hardware and software, optical scanners, optical pointers, digital image capture devices and associated interpretation software, and the like.", "FIG.", "2 illustrates one exemplary embodiment of a computer system 100.As shown, the computer system 100 can include one or more processors 102 which can control the operation of the computer system 100.“Processors” are also referred to herein as “controllers.” The processor(s) 102 can include any type of microprocessor or central processing unit (CPU), including programmable general-purpose or special-purpose microprocessors and/or any one of a variety of proprietary or commercially available single or multi-processor systems.", "The computer system 100 can also include one or more memories 104, which can provide temporary storage for code to be executed by the processor(s) 102 or for data acquired from one or more users, storage devices, and/or databases.", "The memory 104 can include read-only memory (ROM), flash memory, one or more varieties of random access memory (RAM) (e.g., static RAM (SRAM), dynamic RAM (DRAM), or synchronous DRAM (SDRAM)), and/or a combination of memory technologies.", "The various elements of the computer system 100 can be coupled to a bus system 112.The illustrated bus system 112 is an abstraction that represents any one or more separate physical busses, communication lines/interfaces, and/or multi-drop or point-to-point connections, connected by appropriate bridges, adapters, and/or controllers.", "The computer system 100 can also include one or more network interface(s) 106, one or more input/output (IO) interface(s) 108, and one or more storage device(s) 110.The network interface(s) 106 can enable the computer system 100 to communicate with remote devices, e.g., other computer systems, over a network, and can be, for non-limiting example, remote desktop connection interfaces, Ethernet adapters, and/or other local area network (LAN) adapters.", "The IO interface(s) 108 can include one or more interface components to connect the computer system 100 with other electronic equipment.", "For non-limiting example, the IO interface(s) 108 can include high speed data ports, such as universal serial bus (USB) ports, 1394 ports, Wi-Fi, Bluetooth, etc.", "Additionally, the computer system 100 can be accessible to a human user, and thus the IO interface(s) 108 can include displays, speakers, keyboards, pointing devices, and/or various other video, audio, or alphanumeric interfaces.", "The storage device(s) 110 can include any conventional medium for storing data in a non-volatile and/or non-transient manner.", "The storage device(s) 110 can thus hold data and/or instructions in a persistent state, i.e., the value is retained despite interruption of power to the computer system 100.The storage device(s) 110 can include one or more hard disk drives, flash drives, USB drives, optical drives, various media cards, diskettes, compact discs, and/or any combination thereof and can be directly connected to the computer system 100 or remotely connected thereto, such as over a network.", "In an exemplary embodiment, the storage device(s) can include a tangible or non-transitory computer readable medium configured to store data, e.g., a hard disk drive, a flash drive, a USB drive, an optical drive, a media card, a diskette, a compact disc, etc.", "The elements illustrated in FIG.", "2 can be some or all of the elements of a single physical machine.", "In addition, not all of the illustrated elements need to be located on or in the same physical machine.", "Exemplary computer systems include conventional desktop computers, workstations, minicomputers, laptop computers, tablet computers, personal digital assistants (PDAs), mobile phones, and the like.", "The computer system 100 can include a web browser for retrieving web pages or other markup language streams, presenting those pages and/or streams (visually, aurally, or otherwise), executing scripts, controls and other code on those pages/streams, accepting user input with respect to those pages/streams (e.g., for purposes of completing input fields), issuing HyperText Transfer Protocol (HTTP) requests with respect to those pages/streams or otherwise (e.g., for submitting to a server information from the completed input fields), and so forth.", "The web pages or other markup language can be in HyperText Markup Language (HTML) or other conventional forms, including embedded Extensible Markup Language (XML), scripts, controls, and so forth.", "The computer system 100 can also include a web server for generating and/or delivering the web pages to client computer systems.", "In an exemplary embodiment, the computer system 100 can be provided as a single unit, e.g., as a single server, as a single tower, contained within a single housing, etc.", "The single unit can be modular such that various aspects thereof can be swapped in and out as needed for, e.g., upgrade, replacement, maintenance, etc., without interrupting functionality of any other aspects of the system.", "The single unit can thus also be scalable with the ability to be added to as additional modules and/or additional functionality of existing modules are desired and/or improved upon.", "A computer system can also include any of a variety of other software and/or hardware components, including by way of non-limiting example, operating systems and database management systems.", "Although an exemplary computer system is depicted and described herein, it will be appreciated that this is for sake of generality and convenience.", "In other embodiments, the computer system may differ in architecture and operation from that shown and described here.", "Robotic Surgical Systems The systems, devices, and methods disclosed herein can be implemented using a robotic surgical system.", "Various embodiments of robotic surgical systems are described in further detail in U.S. Pat.", "No.", "8,831,782 filed Jul.", "15, 2013 entitled “Patient-Side Surgeon Interface For A Teleoperated Surgical Instrument,” Intl.", "Pat.", "Pub.", "No.", "WO2014151621 filed Mar.", "13, 2014 entitled “Hyperdexterous Surgical System,” Intl.", "Pat.", "Pub.", "No.", "WO2014151952 filed Mar.", "13, 2014 entitled “Compact Robotic Wrist,” and U.S. Pat.", "Pub.", "No.", "2012/0158013 filed Dec. 17, 2010 entitled “Surgical System And Methods For Mimicked Motion,” which are hereby incorporated by reference in their entireties.", "As will be appreciated by a person skilled in the art, electronic communication between various components of a robotic surgical system can be wired or wireless.", "A person skilled in the art will also appreciate that all electronic communication in the system can be wired, all electronic communication in the system can be wireless, or some portions of the system can be in wired communication and other portions of the system can be in wireless communication.", "FIG.", "3 illustrates an embodiment of a robotic surgical system 200 configured to be used by a user 202 (e.g., a surgeon, a surgical assistant, etc.)", "during performance of a surgical procedure on a patient 204.As in this illustrated embodiment, the robotic surgical system 200 can include a controller 206, motors 208, and a movement mechanism 210.The controller 206 can be configured to receive an input from the user 202 requesting movement, relative to the patient 204, of a surgical instrument coupled to the movement mechanism 210.The controller 206 can be configured to cause the motors 208 to drive movement of the movement mechanism 210, thereby causing the movement of the surgical instrument requested by the user 202.Although the illustrated robotic surgical system 200 includes a plurality of motors 208, a robotic surgical system can include a single motor.", "Similarly, although the illustrated robotic surgical system 200 includes a single controller 206 and a single movement mechanism 210, a robotic surgical system can include a plurality of controllers and/or a plurality of movement mechanisms.", "In an exemplary embodiment, the movement mechanism 210 can include an arm.", "The arm can be configured to move so as to cause movement of a surgical instrument coupled thereto in any one or more of the three translational directions (surge, heave, and sway) and in any one or more of the three rotational directions (roll, pitch, and yaw) in response to control by the controller 206.In an exemplary embodiment, the arm can be configured to provide a plurality of degrees of freedom.", "More than six degrees of freedom can be provided in a variety of ways, as mentioned above and as will be appreciated by a person skilled in the art.", "In general, the arm can include a mechanical member configured to move in response to an input to the system 200 from the user 202.The user's input can be configured to cause the controller 206 to transmit an electronic signal to the motors 208 that causes the motors 208 to provide a force (e.g., torque) to the arm, thereby causing movement of the arm.", "The arm can include a plurality of members jointed together, which can facilitate movement of the arm in a plurality of degrees of freedom via bending, twisting, etc.", "at various ones of the joints.", "The arm can include an electromechanical arm.", "The electromechanical arm can include one or more mechanical members configured to move in response to an electronic input.", "Examples of mechanical members that can form the arm include elongate shafts, coupling mechanisms (e.g., clips, magnets, snap fit mechanisms, shaped members configured to seat an instrument therein by interference fir or press fit, clamps, protrusions configured to be seated in corresponding depressions formed in a surgical instrument, depressions configured to receive therein corresponding protrusions extending from a surgical instrument, etc.)", "configured to removably and replaceably couple a surgical instrument to the arm, and joints (e.g., hinges, gimbals, etc.).", "FIGS.", "4 and 5 illustrate an embodiment of an arm 300 in the form of an electromechanical arm.", "The arm 300 is mounted to a surgical table 302 using a frame 304 in the illustrated embodiment of FIG.", "4, but the arm 300 can be mounted to any of a variety of stationary items, a wall, a table, a cart, the ceiling, etc., in any of variety of ways to help stabilize the arm 300 for use during a surgical procedure.", "The arm 300 can include an active portion 300a configured to be actively controlled, e.g., configured to move in response to electronic input, and a passive portion 300b configured to be passively controlled, e.g., configured to move in response to hand or other manual movement thereof.", "The passive portion 300b can lack motors or other electrical features, while the active portion 300a can include motors and other electrical features, such as associated with the joints, to facilitate electronic control thereof In at least some embodiments, an arm can lack a passive portion so as to be configured to be entirely actively controlled.", "While the active and passive portions 300a, 300b are sometimes referred to herein as components of a single arm, a person skilled in the art will appreciate that the active portion 300a and the passive portion 300b can be separate arms that are matable to each other.", "The arm 300 can, as in this illustrated embodiment, include a plurality of mechanical members 306, a plurality of joints 308, and a coupling mechanism 310.Adjacent ones of the mechanical members 306 can be attached together at one of joints 308.In this illustrated embodiment, the active portion 300a of the arm 300 includes five mechanical members 306 and four joints 308, the passive portion 300b of the arm 300 includes two mechanical members 306 and three joints 308, and the arm 300 includes another joint 308 between the active and passive portions 300a, 300b, but arms can have any number of mechanical members and associated joints in its active and passive portions.", "As shown in FIG.", "5, the arm 300, e.g., the active portion 300a thereof, can be configured to removably and replaceably couple to a surgical instrument 312 via the coupling mechanism 310.A distal end 314 of the instrument 312 can be configured to be advanced into a body of a patient, e.g., through an incision, through a natural orifice, etc.", "The instrument's distal end 314 can thus include a working end of the instrument 312 configured to facilitate performance of the surgical procedure within the patient.", "The instrument's distal end 314 can include an end effector, e.g., forceps/graspers, needle drivers, scissors, electrocautery hooks, staplers, clip appliers/removers, suction tools, irrigation tools, etc.", "As in this illustrated embodiment, the instrument 312 can be advanced into a patient's body through a cannula 316 (e.g., a trocar, an introducer tube, etc.).", "The coupling mechanism 310 is shown in FIG.", "5 coupled to the cannula 316, which has the surgical instrument 312 advanced therethrough.", "Aspects of the arm 300 and the frame 304 are further described in previously mentioned Intl.", "Pat.", "Pub.", "No.", "WO2014151621 filed Mar.", "13, 2014 entitled “Hyperdexterous Surgical System” and Intl.", "Pat.", "Pub.", "No.", "WO2014151952 filed Mar.", "13, 2014 entitled “Compact Robotic Wrist.” FIG.", "6 illustrates another embodiment of an arm 400 in the form of an electromechanical arm.", "The arm 400 can generally be configured and used similar to the arm 300 of FIGS.", "4 and 5.The arm 400 can include a plurality of mechanical members 402, a plurality of joints between adjacent ones of the mechanical members 402, and a coupling mechanism 404 configured to removably and replaceably couple to a surgical instrument I.", "The arm 400 includes five mechanical members 402 and four joints in this illustrated embodiment, but as mentioned above, arms can have any number of mechanical members and associated joints.", "As shown in FIGS.", "6 and 7, the arm 400 can be included in a robotic surgical system 406 configured to facilitate performance of a surgical procedure on a patient P. FIG.", "8 shows an example of the system 406 in use.", "As in this illustrated embodiment, the system 406 can include a user interface sub-system 408 that can include at least one display 410 configured to display information thereon to a user U, at least one user input device 412 configured to receive a user input thereto to control movement of the arm 400, a visualization system 414 that can include at least one display 416 configured to display thereon image(s) of a surgical procedure being performed using the system 406, a freely movable user input device 418 (shown as pinchers in this illustrated embodiment) configured to receive a user input thereto to control movement of the arm 400 and configured to be freely moved around by the user U (e.g., handheld and moved around any space in or near an operating room, etc.", "), an additional arms 422 that can be configured and used similar to the arm 400, and a control system 426 configured to facilitate control of the arms 400, 422 by translating user inputs to the user input devices 412, 418, e.g., manual movement of a user input device, movement indicated by touch on a touch screen, etc., to one or both of the arms 400, 422 as appropriate.", "The system 406 in this illustrated embodiment includes two arms 400, 422, but it can include another number of arms, e.g., three, four, etc.", "The at least one display 410 of the user interface sub-system 408 can be configured as a user input device, e.g., as a touchscreen configured to receive user touch input thereon.", "The user interface sub-system 408 can be in the same room as the patient P, or it can be in a different room.", "The control system 426 can, as in this illustrated embodiment, include at least one computer 428, one or more cables 430, and at least one power supply 432.The computer 428 can include at least one processor (not shown).", "As mentioned above, some embodiments of control systems can be at least partially wireless, in which case at least some of the cables 430 need not be present.", "The robotic surgical system 406 can include at least one foot pedal 434 coupled to the computer 428 via one of the cables 430, which can allow the foot pedal 434 to serve as a user input device.", "The robotic surgical system 406 can include a frame 424 for each of the arms 400, 422.The frames 424 in this illustrated embodiment are each mounted to a surgical table 426, but as mentioned above, frames can be mounted elsewhere.", "The frame 424 in this illustrated embodiment includes a vertical extension movably coupled to a rail mounted to the table 426.The vertical extension can be configured to move along the rail, thereby facilitating positioning of the arms 400, 422 relative to the patient P. One or more manually operated surgical instruments 420, e.g., instruments not under the control of the robotic surgical system 406, can be used to perform the surgical procedure being performed on the patient P. Aspects of the robotic surgical system 406 are further described in previously mentioned Intl.", "Pat.", "Pub.", "No.", "WO2014151621 filed Mar.", "13, 2014 entitled “Hyperdexterous Surgical System.” FIG.", "9 illustrates another embodiment of a robotic surgical system 500.As in this illustrated embodiment, the robotic surgical system 500 can include a display 502 and a control system 504 configured to be in electronic communication with the display 502.The display 502 and the control system 504 are in wired electronic communication in this illustrated embodiment, but the electronic communication can be wireless.", "The control system 504 can include a computer system including a display controller 506 configured to facilitate the display of images on the display 502, such as images of tissue 508 visualized by an endoscope 510 coupled to the control system 504.The display 502 can be coupled to handles 512a, 512b configured to facilitate manual movement of the display 502, a hand-tracking transmitter 514 configured to generate a field (e.g., an electromagnetic field, an optical field (e.g., light beams), etc.", "), a surgeon's viewer 516 (e.g., glasses, etc.)", "configured to facilitate three-dimensional (3-D) viewing of 3-D images shown on the display 502, and a boom 518 configured to mount the display 502 to a stable surface (e.g., a wall, a table, etc.).", "The display 502 can be configured to show two-dimensional (2-D) and/or 3-D images.", "Movement of a user-controlled master tool 520, an embodiment of which is illustrated in FIG.", "10, in the field generated by the transmitter 514 can be configured to provide sensed spatial position and orientation information in a 3-D coordinate system.", "The master tool 520 can be configured to transmit the spatial position and orientation information to the control system 504, such as by cables 522a, 522b.", "The control system 504, e.g., a processor thereof, can be configured to receive the transmitted spatial position and orientation information and, in response thereto, cause a slave tool 524 to move in accordance with the user's movement of the master tool 520.The robotic surgical system 500 can thus allow control of the slave tool 524 via the master tool 520.The master tool 520 in this illustrated embodiment includes first and second master tool grips 520a, 520b that each include a plurality of levers 526, a plurality of finger loops 528, a palm rest 530, and a mode control button 532, but the master tool 520 can have a variety of other configurations, as will be appreciated by a person skilled in the art.", "The robotic surgical system 500 can include any number of master tools and any number of slave tools each configured to be controlled by the master tool(s).", "One or more manually operated surgical instruments 534 can be used to manipulate the tissue 508 in addition to the slave tool 524 that can manipulate the tissue 508.FIG.", "9 illustrates first, second, third, and fourth coordinate systems C1, C2, C3, C4 representing local coordinates that specify the respective position and orientation of the portion of the system 500 with which they are associated.", "The first coordinate system C1 is associated with the manually operated surgical instrument 534.The second coordinate system C2 is associated with the slave tool 524.The third coordinate system C3 is associated with a user (not shown) visualizing the display 502, and hence also with the master tool 520 configured to be manipulated by the user.", "The fourth coordinate system C4 is associated with the control system 506, and hence also with images that the control system 506 causes to be displayed on the display 502.In general, the control system 506 can be configured to map and translate the third coordinate system C3 into the second coordinate system C2, e.g., map and translate movement of the master tool 520 to movement of the slave tool 524.The control system 506 can be configured to always orient the display 502 so that the first, second, and third coordinate systems C1, C2, C3 are aligned to the third coordinate system C3.For example, if the user is holding the master tool 520, e.g., one of the first and second master tool grips 520a, 520b, in one of his/her hands and moves that hand to his/her right, thereby moving the held master tool 520 to the right, the control system 506 can be configured to correspondingly cause a working end of the slave tool 524 to move to the right.", "This movement can be accomplished by the control system 506 causing an arm to which the slave tool 524 is coupled, similar to the arms discussed herein, to move.", "This movement of the slave tool 523 can “correct” for pivoting of a trocar (not shown) through which the slave tool 524 may be inserted to access the tissue 508.Aspects of the robotic surgical system 500 are further described in previously mentioned U.S. Pat.", "No.", "8,831,782 filed Jul.", "15, 2013 entitled “Patient-Side Surgeon Interface For A Teleoperated Surgical Instrument.” Some robotic surgical systems have tools or end effectors (e.g., jaws, tissue graspers, etc.)", "that are capable of applying forces of a high magnitude (e.g., compressive and tensile forces) to affected tissue or to an instrument or device affecting tissue.", "Because the robotic surgical systems are typically configured such that no feedback is generated for a surgeon to assess the amount of force applied to tissue, surgeons typically manually control the force applied to tissue based on their experience.", "Thus, when a less experienced person performs a surgery, or when a surgeon misjudges the applied force, unintended tissue trauma can be caused as a result of excessive force being applied to the tissue.", "Another undesired consequence of the lack of control over the applied forces is the potential for suture to be damaged or broken when a tool and/or an arm is used to pull the tissue with an excessive force.", "The lack of control over the applied forces can thus compromise the efficiency and/or outcome of the surgery.", "Accordingly, some embodiments provide a force limiting technique to control and limit a force applied to tissue by a surgical tool or end effector.", "The applied force can be controlled such that it cannot exceed a predetermined threshold force.", "Such a threshold force can be the maximum force value that a surgical tool (e.g., jaws or other tissue grasping tips) can apply to tissue before deflecting or otherwise becoming unable to apply a greater force.", "Once the maximum force value is established, the surgical tool can be used with little or no risk of damaging tissue as a result of the application of excessive force.", "As explained below, such force limiting techniques can be implemented in one or more mechanical components.", "Additionally or alternatively, the techniques can be implemented as one or more software components, or as a combination of hardware and software.", "A force limiter can be associated with at least one of an electromechanical arm and an electromechanical surgical tool or end effector mounted to the arm.", "The force limiter can be configured such that, during movement or use of at least one of the electromechanical arm and the electromechanical surgical tool, the force applied as a result of such movement or use is limited to a threshold force value.", "When the force is limited in a mechanical way, a maximum force value can be set up based on a user input received by a force limiting adjustment component.", "When software component(s) are used to control the force, user input can be received via a suitable input device, such as a user interface of system 408 shown in FIG.", "6 above, or via another device.", "Regardless of the way in which the maximum force value is established, it can have various values.", "For example, novice users can set a lower value, whereas more experienced users can use larger maximum force values.", "The force limiter can be implemented such as a user can establish a maximum force value based on various factors, such as a type of procedure, a type of tissue, a type of suture, previously used maximum force values (which can be logged in a suitable storage device), and other relevant factors.", "A force limiting mechanism can be disposed at a number of different locations on a surgical instrument.", "For example, it can be disposed on one or more electromechanical arms and/or on one or more electromechanical surgical tools.", "The force limiter can have a number of different configurations.", "In some embodiments, it can be implemented as a slip clutch.", "FIG.", "11 illustrates an example of an end effector end or an electromechanical surgical tool 600 configured to perform a surgical function and which can include a force limiter in accordance with the described techniques.", "The tool 600 can be mounted on a distal end of a shaft 604 of a surgical instrument of a surgical system, such as a robotic surgical system (not shown).", "The surgical instrument can be removably and replaceably coupled to an electromechanical arm, such as an active arm or a passive arm of a robotic surgical system.", "The electromechanical arm can be configured for movement in multiple axes.", "As discussed above, the electromechanical arm can be coupled to a fixture which can be any suitable support member or other component.", "In this example, the tool 600 can be an end effector in the form of a grasper mechanism including a pair of jaws 606A, 606B.", "The tool 600 can be implemented, for example, similar to a tool of a robotic surgical system described in U.S. Pat.", "Pub.", "No.", "2015/0150635 filed Sep. 25, 2014, entitled “Compact Robotic Wrist,” which is hereby incorporated by reference in its entirety.", "It should be appreciated, however, that the tool can be or can include other types of end effectors, as the described techniques are not limited to any specific type(s) of an end effector.", "As shown in FIG.", "11, a proximal end 600p of the tool 600 can have a yoke 608 coupled to the shaft 604.The yoke 608 is movably coupled to a second yoke 610 having brackets 610A, 610B via an extended axle (not shown) that extends along an axis 612.The axle can be removable or integrally formed with the second yoke 610 or the yoke 608.Additionally or alternatively, any other element can be used to movably couple the yokes 608, 610 to one another.", "The tool 600 further includes drive pulleys 614A, 614B, 616A, 616B coupled to the extended axle and arranged along the axis 612 of the extended axle.", "The pulleys 614A, 614B, 616A, 616B are arranged so as to form a first set of pulleys 614B, 616B and a second set of pulleys 614A, 616A.", "The first set of pulleys 614B, 616B are on one side of the second yoke 610, and the second set of pulleys 614A, 616A are on the other side of the second yoke 610.As shown in FIG.", "11, the pulleys 614A, 614B are outer pulleys and the pulleys 616A, 616B are inner pulleys, with reference to the orientation of the pulleys as shown in FIG.", "11.It should be appreciated that a set of pulleys can include any suitable number of pulleys, including one, two, or more than two (e.g., three, four, five, six, etc.)", "pulleys.", "As further shown in FIG.", "11, the brackets 610A, 610B of the second yoke 610 are coupled to a third set of pulleys 618A, 618B that are arranged along an axis 620 extending through the brackets 610A, 610B.", "The tool 600 can be actuated to move one of both of the jaws 606A, 606B in a variety of ways around the axis 620.For example, the jaws 606A, 606B may open and close relative to each other.", "The jaws 606A, 606B can also rotate together as a pair to provide a yaw motion and/or a pitch motion of the tool 600.The surgical system can include various cables appropriately configured to enable motion of the jaws 606A, 606B.", "As shown in FIG.", "11 and further shown in FIG.", "12A, illustrating a portion of the tool 600 in cross-section along the axis 620, each of the pulleys 618A, 618B can be configured as a disk or gear having a bore or a groove that has a respective cable of the cables 619A, 619B extending therethrough.", "In the example illustrated, the cables 619A, 619B extend through the pulleys 618A, 618B such that the cables 619A, 619B are prevented from slipping or sliding relative to the pulleys 618A, 618B via beads 621A, 621B (or other components) coupled to or integrally formed with the ends of the cables 619A, 619B.", "A person skilled in the art will appreciate that the cables 619A, 619B can be coupled to the pulleys 618A, 618B in a number of different ways.", "As shown in FIG.", "12A, the second yoke 610 can include an extended axle or pin 622 that extends along the axis 620.The pin 622 can be removably coupled with the second yoke 610 or it can be monolithically and/or integrally formed therewith.", "As shown in FIGS.", "11, 12A, and 12B, the jaws 606A, 606B of the tool 600 can be coupled to the second yoke 610 via the third set of pulleys 618A, 618B, such that the jaws 606A, 606B can rotate about the axis 620.The pin 622 extends along the axis 620 and can allow rotation of the jaws 606A, 606B and the pulleys 618A, 618B along the axis 620 that coincides with the axis of the pin 622.The pin 622 can be coupled to the brackets 610A, 610B in a number of ways (e.g., laser welded into the brackets, swaged, riveted, screwed into place, etc.).", "FIG.", "12A illustrates a portion of the tool 600 that can have a force limiter associated therewith.", "The force limiter in the form of a slip clutch can be formed by the virtue of the configuration of the components of the tool 600 shown in FIG.", "12A.", "Thus, in use, as the jaws 606A, 606B close to engage tissue therebetween, the pulleys 618A, 618B move the jaws 606A, 606B through friction, until a certain magnitude of friction is reached, beyond which the pulleys 618A, 618B slip with respect to the jaws 606A, 606B, respectively, thereby creating a slip clutch force limiter.", "In this example, the threshold (e.g., maximum allowed) level of friction corresponds to a maximum compressive force applied by the jaws.", "In other words, when a predetermined value of friction is achieved, continued rotation of the pulleys 618A, 618B fails to advance the jaws 606A, 606B further towards each other.", "FIG.", "12B additionally illustrates that the portion of the tool 600 shown in FIG.", "12A can include springs 630 (e.g., wave springs or other resilient component(s)) disposed between a bracket of the brackets 610A, 610B and at least one of the drive pulleys 618A, 618B.", "Although two springs 630 are shown in FIG.", "12B, it should be appreciated that only one of the springs can be present.", "The spring(s) 630 can be configured to force the pulleys 618A, 618B against the jaws 606A, 606B so that the respective teeth of the jaws and the pulleys are operatively engaged.", "As the jaws 606A, 606B close, the pulleys 618A, 618B move the jaws 606A, 606B through friction, until a certain level of friction is reached, beyond which the spring force is overcome and the pulleys 618A, 618B slip with respect to the jaws 606A, 606B, respectively.", "FIGS.", "13A, 13B, and 14 illustrate other examples of force limiters associated with an electromechanical tool.", "In these examples, a jaw and a pulley's disk or gear are engageable via a ratchet-tooth-type mechanism such that the jaw and the gear move together until a certain threshold amount of force is reached, at which point they “slip” with respect to each other and become disengaged from each other.", "FIGS.", "13A and 13B illustrate a portion of an electromechanical tool 640 that is similar to electromechanical tool 600 in FIGS.", "11 and 12A.", "Thus, like tool 600, the tool 640 includes jaws 646A, 646B, drive pulleys 648A, 648B, and brackets 650A, 650B of a yoke 650, all of which are movably held together via a pin 652.As shown in FIG.", "13A, and in more detail in FIG.", "13B illustrating a portion of FIG.", "13A, the jaws 646A, 646B have teeth 654 on a side thereof facing the pulleys 648A, 648B, and the teeth 654 can be configured to engage with corresponding teeth 656 formed on a side of the pulleys 648A, 648B facing the 646A, 646B.", "The teeth 654, 656 form a ratchet mechanism similar to the slip clutch in FIG.", "12B.", "The ratchet mechanism can control a slippage of the jaws 646A, 646B with respect to one another.", "Because of the way the teeth 654, 656 are configured to engage with each other, such ratchet mechanism can be advantageous in surgical environments where fluids (e.g., blood and other fluids) can affect a friction between the jaws 646A, 646B and between the jaws 646A, 646B and the pulleys 648A, 648B in various ways.", "Specifically, the configuration of the teeth 654, 656 can enable limiting the force applied by the jaws 646A, 646B in a more controlled and accurate manner.", "The jaws and pulleys of an electromechanical tool can frictionally engage so as to form a force limiter having a number of different configurations.", "In the example of FIGS.", "13A and 13B, the teeth 654, 656 are configured as sharp-angled teeth.", "FIG.", "14 illustrates another example of a tool where a force limiter is associated with the jaws and where teeth have a more curved configuration.", "Specifically, as shown in FIG.", "14, illustrating a portion of the tool, a jaw 660 and a pulley 662 are engageable via respective teeth 664, 666 that have a wavy curved surface.", "Other jaw and pulley of the electromechanical tool can be configured to engage in the same or similar manner.", "As mentioned above, teeth formed on surfaces of the jaws and pulleys facing each other can have various configurations, including sharp, curved, angled in any manner, and any other types of teeth forming regular or irregular patterns.", "Furthermore, the surface features formed on surfaces of the jaws and pulleys facing each other can be other than teeth.", "As a further variation, the surface features can be formed on opposing slip plates or other components disposed between a jaw and pulley, rather than on the surfaces of the jaw and the pulley.", "Furthermore, although not shown in FIGS.", "13A, 13B, and 14, the tools shown in these figures, as well as any other tools having a force limiter, can have a spring (e.g., wave spring or other spring such as, e.g., springs 630 shown in FIG.", "12B) or other mechanism(s) configured to compress the components of the tool together.", "FIG.", "15 illustrates a further example of a force limiter including one or more spacer shims or slip plates 684A, 684B disposed between jaws of an end effector of an electromechanical tool.", "An electromechanical tool 670 of the type shown in FIG.", "15 can be similar to electromechanical tool 600 in FIGS.", "11 and 12A.", "Thus, like tool 600, the tool 670 includes jaws 676A, 676B, drive pulleys 678A, 678B, brackets 680A, 680B of a yoke 680, and a pin 682.As shown in FIG.", "15, the tool 670 can have the spacer shims in the form of slip plates 684A, 684B disposed between the jaws 676A, 676B in a way such that they do not interfere with operation of the jaws 676A, 676B.", "Although not shown in FIG.", "15, the jaws 676A, 676B can be angled toward one another.", "The slip plates 684A, 684B can be configured to have opposed complementary ramped surfaces.", "The relative position of the slip plates 684A, 684B is adjustable so as to increase or decrease the threshold force.", "In the example shown in FIG.", "15, movement of the slip plates towards one another increases the threshold force, while movement of the slip plates away from one another decreases the threshold force.", "The slip plates 684A, 684B can be moved and adjusted via a motor, a solenoid, a mechanical controller, a robotic controller, manually, or in any other manner or via a combination of different ways.", "For example, in at least some embodiments, the slip plates 684A, 684B can be adjusted manually or automatically via a screw or other mechanism (not shown).", "The slip plates 684A, 684B can have various configurations.", "In the example of FIG.", "15, the slip plates 684A, 684B are configured as inclined plates, with the plate 684A being inclined toward the distal-most end of the jaws and the plate 684B being inclined in the opposite direction.", "It should be appreciated that the inner surfaces of the jaws 676A, 676B can be angled toward each other or configured in other manner such that the slip plates 684A, 684B do not interfere with operation of the jaws 676A, 676B as they move to engage tissue and/or for other purposes.", "As discussed above, a spring or other component can optionally be positioned between the bracket and pulley.", "FIG.", "16 illustrates an example of an electromechanical tool 800 that has a force limiter in the form of a bellows 812 disposed between jaws of the tool's end effector.", "The electromechanical tool 800, which can be similar to electromechanical tool 600 (FIGS.", "11 and 12A), includes jaws 806A, 806B, drive pulleys 808A, 808B, brackets 810A, 810B of a yoke 810, and a pin (not shown).", "FIG.", "16 also illustrates cables 809A, 809B extending through the drive pulleys 808A, 808B.", "The bellows 812 disposed between the jaws 806A, 806B is configured to controllably deform (e.g., expand or contract) so as to increase or decrease a friction force between the jaws 806A, 806B and the pulleys 808A, 808B.", "The bellows 812 can be operated, for example, by fluid the flow of which in or out of the bellows is controlled by a valve 813 and via a conduit 814.The bellows 812 thus expands or contracts to thereby increase or decrease the frictional force between the jaws and the pulleys.", "As discussed above, the tool 800 can optionally have a spring or other component disposed between the bracket and the pulley.", "The force limiter in accordance with the described techniques can be implemented in a number of ways.", "In some embodiments, for example, it can be implemented via software, e.g., the form of what is referred to as a software clutch.", "Such a software clutch can generally be formed by components that automatically control force applied by one or more cables driving an end effector of an electromechanical tool.", "An example of such an embodiment of a force limiter 820 is shown in FIG.", "17 illustrating a cable 822 that can be operated by applying a desired amount of tension thereto to thereby operate an end effector of an electromechanical tool (not shown).", "A person skilled in the art will understand that two or more cables can be used to operate the end effector, and that only one cable 822 is shown in FIG.", "17 by way of example only.", "The force limiter 820 can include a motor 824 that is driven by a drive voltage 826.The motor torque is proportional to current applied thereto and the force of the cable 822 is proportional to the motor torque.", "A current meter 828 can be used to control the current such that limiting the current causes a force applied by the cable 822 (via tensioning thereof) to be limited.", "In this way, the end effector driven via the cable 822 is controlled to apply a force to tissue that does not exceed a certain threshold value.", "Software-based force-limiting control techniques can be applied to various components that are used to operate jaws or other end effectors of an electromechanical surgical tool.", "For example, the force limiter can be in the form of a pseudo-clutch having magnets.", "The magnets can be incorporated into suitable locations on opposed surfaces of the jaws (e.g., jaws 606A, 606B of tool 6000 in FIG.", "11).", "The magnitude of the threshold force can be controlled by controlling the amount of current through the coil.", "The examples described above in connection with FIGS.", "11, 12A, 12B, 13A, 13B, and 14-17 illustrate a force limiter associated with an electromechanical surgical tool.", "In some embodiments, as mentioned above, force limiters of the type described above can be adapted to use with an electromechanical arm to limit the force that is applied as a result of moving the electromechanical arm.", "Thus, components of the arm that move with respect to each other when the arm is operated can be controlled to interact with a frictional force created therebetween that is limited to a certain threshold value.", "Regardless of the particular implementation of a force limiter, it can be configured to control application of a force by an electromechanical arm or by an electromechanical surgical tool such that the force does not exceed a threshold force value.", "The threshold force value can be established in a number of different ways.", "In some embodiments, the threshold force value can be established based on a user input which can be received in various ways.", "For example, the user input can be received with respect to one or more mechanical components of a force limiter, by adjusting settings and/or position of the component(s).", "The force limiter can include or can be associated with a specific force limiter adjustment mechanism that can be configured to receive input with respect to setting and/or adjusting the threshold force value.", "For another example, the user input can be received via a user interface, such as a user interface of system 408 shown in FIG.", "6.The user interface can be configured to receive a user input in a suitable format, and one or more parameters relating to the threshold force value can be generated and transmitted to the force limiter.", "Regardless of the specific way in which it is implemented, the threshold force value can be preselected prior to operation of the surgical system.", "Furthermore, in some cases, the threshold force value can be adjusted as the surgical instrument is being operated, or at a time period when the instrument is not in use.", "The threshold force value can be selected from a certain number of discrete and/or continuous values.", "In some embodiments, the threshold force value can be set in response to receiving user input indicating a selection of a certain mode, such as a tissue type mode, a surgical experience mode, etc.", "FIG.", "18 is a flowchart illustrating an example of a process 900 of selecting a threshold force value for a force limiter of a tool of a surgical instrument in accordance with some embodiments.", "The process 900 can be implemented by a suitable controller, which can be, for example, a computing device that can be communicatively coupled to a display configured to render a user interface.", "The computing device can be configured to receive user input with respect to selection of threshold force values via the user interface.", "Furthermore, in some embodiments, a threshold force value can be selected via one or more control features (e.g., knobs, switches, and other features) associated with the force limiter.", "Such control features can be coupled to the force limiter directly or via other components, and they can be disposed at various locations with respect to the force limiter.", "After the selection process starts at block 902 in a suitable manner (e.g., when an operation of the surgical instrument is initiated), it can be determined, at decision block 904, whether a force limiting mode is selected.", "This can be done in a number of ways.", "For example, the user interface can present a respective representation (e.g., graphical, textual, voice-based, etc.)", "and a suitable user input can be received with respect to this representation.", "When it is determined that the force limiting mode is not selected, the process 900 branches to block 906 where a maximum allowed force value for a tool can be set as the threshold force value.", "As further shown in FIG.", "18, when it is determined, at decision block 904, that the force limiting mode is selected, the process 900 can proceed to decision block 908 where it is determined whether a request to set up a certain force limiting mode is received.", "When the force limiting mode is not selected (e.g., no input with respect to selection of a mode is received), the process 900 can return to block 904.However, when the force limiting mode is selected, next, at block 910, an input can be acquired indicating a selection of a force limiting mode.", "The force limiting mode can be selected from a number of different modes.", "For example, one or more modes can correspond to a threshold force value suitable for certain tissue type(s) to be manipulated by the tool, or to a strength of a suture to be used.", "Additionally or alternatively, one or more modes can correspond to a threshold force value suitable for a certain level of experience of a surgeon.", "As another example, a “free selection” mode can be used in which a user input can be received indicating a setting of a threshold force to any desirable and appropriate value.", "Also, a mode can be selected from a set of preselected settings for a maximum force value, such as, for example, “high,” “medium,” and “low.” The set of preselected settings can include any suitable numbers of settings.", "Any other modes can be used additionally or alternatively.", "The modes can be presented to a user in a manner that allows establishing a force limiting threshold in a more intuitive manner, such that a selection of a particular numerical value is not required.", "A desired mode can instead be selected and a force value associated with the selected mode can be then used for a force limiter.", "After the input with respect to a selected mode is received at block 910 and the force limiting mode is thereby selected, the process 900 proceeds to block 912 where force limiting parameters can be set based on the selected force limiting mode.", "In this way, the force limiter is limited to a maximum force value.", "The process 900 can then end at block 913.It should be appreciated, however, that, in some embodiments, a threshold force value can be adjusted during operation of a surgical instrument.", "Further, a person skilled in the art will understand that the process 900 is shown by way of example only, as a threshold force value can be selected and adjusted in various other ways.", "As mentioned above, a force limiter in accordance with the described techniques can have a number of different variations.", "The maximum force that the force limiter allows a tool or an arm associated therewith to apply can be adjusted.", "Furthermore, in some embodiments, a surgical instrument having a force limiter can be preset to a maximum force value that is not changeable by a surgeon.", "In such embodiments, multiple surgical instruments can be used, each having a certain maximum force value preset for its force limiter.", "In some embodiments, one or more sensors of suitable type(s) can be associated with a force limiter.", "For example, a pressure sensor can be incorporated into surfaces of surgical tool's jaw that interact with one another to implement the force limiter.", "The force sensor can be associated with jaws of a working end of a surgical instrument, for example, if the instrument is to be used in environments where liquids (e.g., blood or other fluids) can interfere with proper functioning of the force limiter.", "For example, one or more force sensors can be used to monitor a force applied by the tool, and to provide feedback about the measured force which can be different from a force perceived by the force limiter, due to the additional friction created by the fluids.", "In this way, precision of operation of the force limiter in bloody fields can be improved.", "A robotic surgical system can include one or more electromechanical passive arms coupled to an operating table or other platform and an electromechanical active arm coupled to the passive arm(s).", "The passive arm is used for rough positioning of the active arm; and, once generally positioned, the active arm, which has a surgical tool coupled distally thereto, can be more finely positioned to perform a surgery using the surgical tool.", "Positioning and repositioning of the passive arm can be challenging, particularly during a surgical procedure when it has other components mounted thereto, and when timely and precise adjustment of the surgical system can determine the outcome of the surgery.", "To properly support the active arm, the passive arm needs to act as a sufficiently rigid mounting structure such that unintended perturbations or positional drift and sag in the system do not impact the required performance of the active arm and the surgical system in general.", "The passive arm also needs to be able to withstand the weight of the entire arm prior to and during a surgical procedure, so as to allow a user to easily position the passive and active arms without feeling the burden of the arms' weight.", "In other words, the passive arm should not be overly limp or expressively rigid, which will make it difficult to set and adjust its position.", "Accordingly, the described system provides a way to control and adjust a stiffness of the passive arm.", "Specifically, the surgical system can be configured such that the passive arm's stiffness can be changeable during different stages of a surgical procedure.", "The passive arm can have two or more segments coupled via joints, and a friction (e.g., resistance of the joint(s) to rotation) of one, some, or all of the joints can be automatically adjusted based upon the degree of cantilever or extension of the passive arm.", "In this way, when the passive arm is being positioned, a change in an angle at the arm's joint is detected, and the friction of the joint is adjusted based on that angle.", "The adjustable magnitude of the friction force can be set based on the type of the passive arm, its weight and weight of components mounted thereon, and any other factors.", "A joint of the passive arm can be associated with one or more components allowing its friction and thus the stiffness of the arm to be controlled.", "For example, the joint can be associated with a clutch mechanism or other component such as a mechanical brake, a fluidic brake, software-based friction control component(s), or any other suitable components.", "The passive arm joints can include mechanical springs or other similar components to provide joint's rotational stiffness that varies in proportion to an angular position of the joint that depends of a degree of extension of the passive arm.", "The stiffness of the passive arm's joint arm can be controlled in a number of different ways.", "For example, the joint's stiffness can be selectively controllable by a user by manipulating one or more components on the arm, via mechanical linkages and/or adjustments made based on user input.", "Additionally or alternatively, the stiffness of the passive arm's joint can be controlled using software-based control, e.g., using an electronic feedback to the robotic system controller.", "The joint can include various components that can control its friction, which affects a force required to move the arm.", "The components associated with the joint can be, for example, a mechanical brake, a fluidic brake, a clutch mechanism, or any other components.", "The one or more components can be controlled such that the friction of the joint can be automatically or manually adjusted proportional to an angle at the joint.", "The adjustment can be performed separately for each joint of the arm, for more than one joint, or for all joints of the arms that allow motion in one or more degrees of freedom.", "In some embodiments, the mechanical stiffness can be controlled and adjusted using a clutch mechanism similar to mechanisms described in connection with FIGS.", "11, 12A, 12B, 13A, 13B, 14, 15, 16, and 17.For example, a clutch mechanism in the form of slip plates, or a mechanism having any other suitable configuration, can be used.", "In some embodiments, additionally or alternatively, motors (e.g., motors 208 in FIG.", "3) associated with the joints and operating to cause movement of the arm can be used to establish a torque limit and thus control a stiffness of the joints, as it is perceived by the user.", "A torque applied by the motor is controlled through the control of current supplied to the motor.", "Further, in some embodiments, a gear train system or other similar system can be used to control the torque applied by the motor.", "In some embodiments, one or more of joints of an electrochemical arm (e.g., joints 308 of arm 300 shown in FIGS.", "4 and 5 above) also include a force sensor (not shown in FIGS.", "4 and 5).", "When there is an attempt to move the arm at a joint, for example, when a user begins moving the arm and thus applies a force to the arm in a certain direction, this attempt is detected by the force sensor disposed at that joint.", "In response, a motor driving the arm is caused to move the arm in the direction of the force applied by the user until the force is no longer applied to the arm (e.g., when the user stops moving the arm).", "One or more of any suitable force sensors can be disposed at a joint.", "In some embodiments, data from sensors disposed at each joint of an arm is acquired, and a three-dimensional force applied to all of the joints of the arm is determined based on this sensed data.", "In this way, motors configured to drive the entire arm can be controlled to move the arm in a concerted manner, such that an appropriate amount of force is applied to the arm to move it in a desired manner.", "FIG.", "19 illustrates an example of a robotic surgical system 1000 including an electromechanical passive arm 1002 having a first end 1002a coupled to a fixture 1003 of the surgical system 1000, and a second end 1002b coupled to an electromechanical arm 1004 which can be an active arm.", "The passive and active arms 1002, 1004 can be modular such that they are reversibly coupled to one another and can be separated by a user, or they can be permanently attached to one another.", "In addition, it should be appreciated that one passive arm and one active arm are shown by way of example only, as the surgical system can include more than one passive arm and/or more than one active arm.", "The passive arm 1002, which can have multiple degrees of freedom, can be used for gross or rough positioning of the active arm 1004.After it is positioned as desired, the passive arm 1002 can be locked at that position, which can be done manually (e.g., by manipulating a locking mechanism of the arm) or automatically, as described in more detail below.", "During a surgical procedure, the passive arm 1002 can be repositioned.", "The active arm 1004 includes motors such that it can be dynamically moved to perform a surgery.", "The fixture 1003 can be any suitable support member or other component, suitable examples of which are well known to those skilled in the art.", "The arm 1004 can have a surgical instrument 1005 mounted on a distal end thereof.", "As shown in FIG.", "19, the electromechanical arm 1002 can have a joint 1006 between the first and second ends 1002a, 1002b.", "The joint 1006 connects first and second passive arm segments 1008, 1010.In this example, the second passive arm segment 1010 can move with respect to the fixture at the joint 1006.Thus, the second end 1002b of the passive arm 1002 is configured to move toward and away from the fixture 1003 such that an angle between the first and second arm segments 1008, 1010 increases as a distance between the second end 1002b and the fixture 1003 increases.", "The first passive arm segment 1010 can be fixed at a certain angle with respect to the fixture 1003 and the joint 1006.As shown in FIG.", "19, the joint 1006 between the first and second passive arm segments 1008, 1010 is in the form of a rounded joint.", "However, it should be appreciated that the joint 1006 can have various configurations.", "The joint 1006 can have a sensor 1012 associated therewith that is not shown separately in FIG.", "19.The sensor 1012 can be an angle measurement sensor configured to sense an angle between the first and second passive arm segments 1008, 1010.The sensor 1012 can have any suitable configuration, and it can be in the form of any suitable angle measurement sensor, such as, for example, an optical encoder, magnetic encoder, a strain gage to measure the flexure of a suitable component (e.g., a metal strip) positioned so that it flexes depending on a measured value of an angle, or any other angle measurement sensor.", "The joint 1006 associated with the sensor 1012 can house any number of clutch systems having any suitable configuration.", "A controller of the robotic surgical system can control the use of data acquired by one or more sensors, such as the sensor 1012, by the clutch system(s) of the surgical system.", "A conceptual example of a clutch is shown in FIG.", "20.Regardless of their specific type, the one or more clutches are used to impart an appropriate amount of resistance to motion of the arm 1002 at the joint 1006.Thus, the clutch is controlled such that, depending on the angle between the first and second passive arm segments 1008, 1010 (e.g., as measured by the sensor 1012), a corresponding amount of clutch resistance affects the motion of the arm 1002.In this way, when the second passive arm segment 1010 is moved, the segment 1010 can be facilitated to move in a desired manner while unintentional movements of the arm and its associated components due to its weight are prevented.", "The surgical system 1000 can include any other suitable sensors used to detect that the passive arm 1002 is being moved and/or to measure an angle between the first and second segments of the passive arm 1002.In the example illustrated, the surgical system 1000 further includes a gravity sensor 1014, as schematically shown in FIG.", "19.The gravity sensor 1014 can be disposed at a joint 1016 connecting the passive arm 1002 and the active arm 1004, or in other locations on the passive arm 100.The gravity sensor 1014 can sense an angle at the joint 1016 between the first and second segments of the passive arm 1002 by determining a direction of a gravitational force experienced by the second passive arm segment 1010 relative to the first passive arm segment 1008.Furthermore, additionally or alternatively, the surgical system 1000 can include more than one gravity sensor for determining angles between arms and their segments and/or orientations of the arms and the segments.", "For example, in some implementations, a first gravity sensor can be disposed on the first passive arm segment 1008 and a second gravity sensor can be disposed on the second passive arm segment 1010.Data acquired by the first and second gravity sensors can be used to determine a direction of gravity relative to each of the passive arm segments 1008, 1010 and thus an angle between the passive arm segments 1008, 1010, as well as the orientation of each of the arm segments 1008, 1010 relative to gravity.", "Although not shown in FIG.", "19, it should be appreciated that sensor(s) similar to the sensors 1012, 1014, or sensor(s) of any other type, can be included in the system 1000 and used to determine an angle between the passive arm 1002 and the active arm 1004.Data acquired by such sensors can be used to determine a distance to which the active arm 1004 is extended (or cantilevered) which is, in turn, used to determine how much frictional resistance the clutches or other friction controlling mechanism(s) should supply.", "In some embodiments, in addition to or instead of clutches, the surgical system can include motors that are controlled to prevent unintended motion of j oints of an arm.", "In such embodiments, a torque of the motor can be determined, and the acquired information can be correlated to an expected torque that is anticipated based on an angle of the arm.", "Thus, when a user tries to reposition the arm by moving it at a joint, the increased force on that joint is sensed and recognized as a reposition command.", "The motor(s) can then cause the force that the user needs to apply to reposition the arm to be reduced.", "In this way, the motors facilitate the user's operation of the arm while helping to ensure that the arm can be moved in a desired manner, without excessive effort on the user's part.", "As mentioned above, one or more clutches associated with joints of an arm can have a number of different configurations.", "FIG.", "20 illustrates an example a friction clutch 1020 that can be associated with a joint.", "The clutch 1020 can include clutch disks 1022, 1024 coupled to respective shafts 1023, 1025.For example, referring back to FIG.", "19, if the clutch is disposed at the joint 1006, the shaft 1023 can be coupled to the arm segment 1008 whereas the shaft 1025 can be coupled to the arm segment 1010.As shown in FIG.", "20, a surface 1022a of the disk 1022 faces a surface 1024a of the disk 1024 such that when the surfaces 1022a, 1024a are in contact and move with respect to one another a friction is created therebetween.", "The clutch disks 1022, 1024 are brought closer together by applying force thereto when rotational friction and resistance to movement at the joint are increased, based on an angle at the joint.", "In the described techniques, the friction of the joint is adjusted based on an angle at the joint.", "FIG.", "21 illustrates a robotic surgical system 1040 including an operating room table 1042 that can have a patient 1044 positioned thereon, a passive electromechanical arm 1046 and an active electromechanical arm 1048.The active arm 1048 has a surgical tool 1049 coupled thereto that is configured to perform an operating procedure on the patient 1044.The passive arm 1046 has first and second passive arm segments 1046A, 1046B that are movably coupled to one another by a mechanical joint 1050.The first and second passive arm segments 1046A, 1046B are disposed at an angular orientation with respect to one another, thus forming an angle alpha (α), as shown in FIG.", "21.When the surgical system 1040 is not in use, the passive arm 1046 can be stowed at the operating table 1042, e.g., alongside bed rails 1043 of the operating table 1042.At that time, the first and second passive arm segments 1046A, 1046B are folded against one another, and the angle α is therefore small (e.g., less than 5 degrees).", "To prepare the surgical system 1040 for the surgery, the passive arm 1046 is unfolded and is positioned such that it hovers over the patient 1044 in a bridge-like manner.", "As a result, the second passive arm segment 1046B is moved away from the first passive arm segment 1046A (and therefore away from the rail 1043 or other fixture to which the arm segment 1046A is coupled), and the angle α increases.", "The load (rotational moment) that the passive arm 1046 exerts on the joint is proportional to the angle α.", "Thus, a stiffness of the joint 1050, which depends on friction created therein, corresponds to the angle α.", "The passive arm 1046 is therefore configured to be gravity-balanced and self-supporting.", "In other words, the passive arm has appropriate and adjustable amount of resistance built therein such that it can be moved in a desired manner, independent of a load applied thereto (e.g., by the active arm and/or other components attached thereto).", "Thus, the passive arm 1046 is configured to have a sufficient stiffness of the joint 1050, such that the passive arm 1046 can be easily adjusted under the load caused by its own weight and the weight of the active arm 1048 and/or other components coupled thereto.", "As indicated above, the angle α determines the stiffness of a joint of a passive arm (e.g., the joint 1050 in FIG.", "21) as determined by a friction at the joint.", "The joint stiffness is adjustable depending on an angle at the joint to counteract gravity-induced loads on the arm at that angle.", "As shown in FIG.", "21, the passive arm 1046 has load applied thereto by the active arm 1048 and the surgical tool 1049.The angle α can be proportional to the joint's stiffness, or it can vary in other ways depending on the joint's stiffness.", "The dependency of the joint's stiffness on the angle α can be linear or non-linear.", "When the angle α increases from 0° to 90°, the passive arm is positioned more horizontally (and the passive arm is therefore closer to the fixture at the operating table to which it is coupled).", "As the angle α increases up to about 90°, the joint's stiffness also increases.", "Once the angle α reaches 90° and may increase further, the passive arm is positioned more upright and thus requires less resistance at its joint.", "Thus, as the angle α becomes larger than 90°, the joint's stiffness decreases.", "Referring back to FIG.", "21, different magnitudes of friction of the joint 1050 can be required depending on a deployment configuration (e.g., an angle at the joint 1050) of the passive arm 1046 and at different phases of the robotic surgery.", "Accordingly, the passive arm 1046 can be configured such that a friction of the joint 1050 is adjustable and a stiffness of the passive arm 1046 is controllable by a user (e.g., a surgeon) operating the passive arm 1046.Additionally or alternatively, the friction of the joint 1050 can be controlled via a software-based control, e.g., via feedback signals provided to a robotic controller (e.g., controller 206 in FIG.", "3 or any other controller).", "As another option, the friction of the joint 1050 can be controlled automatically by utilizing one or more components associated with the joint 1050, such as, for example, a clutch mechanism as described above, or any other mechanism (e.g., a mechanical brake, a fluidic brake, etc.).", "In use, unless it is being adjusted, the passive arm is typically locked at a desired position.", "The passive arm can be locked manually, by using a locking mechanism associated with the arm.", "Additionally or alternatively, in some implementations, the passive arm is “locked” when its stiffness is sufficiency high to preclude its movement without a further force applied thereto.", "For example, after a user (e.g., a surgeon) moves the passive arm to position it, the system determines that the arm is no longer being moved, and its stiffness can be increased accordingly.", "This can also occur when the passive arm is locked via a suitable locking mechanism—e.g., when the arm is locked, the stiffness of component(s) controlling a friction of the arm's joint can be set to a “locked” value.", "Accordingly, the stiffness of the “locked” passive arm is greater than the stiffness that is desirable during arm positioning.", "Thus, regardless of the specific way in which the passive arm is “locked,” its stiffness is in an increased condition when it is stationary.", "In this way, a desired position of the passive arm, and therefore positon of components mounted thereon, can be properly maintained.", "However, when the passive arm needs to be positioned again, its stiffness will decrease, to allow the positioning of the arm to be completed in a desired manner.", "The passive arm therefore can operate in different “modes”—a static (“locked”) mode and a dynamic (positioning) mode.", "FIG.", "22 illustrates a process 1060 of setting or adjusting a stiffness of a passive arm (e.g., passive arm 1046 in FIG.", "21, or any other arm) depending on whether the arm is being positioned.", "The process 1060 can be performed by a suitable controller (e.g., controller 206 in FIG.", "3), or by any other component(s).", "For example, the process 1060 can be performed by one or more processors of a computing system (e.g., processor 102 of computer system 100 in FIG.", "2).", "Furthermore, the process 1060 can be performed by one or more mechanical components, and/or by a combination of components of various types.", "As shown, the process 1060 can start at block 1062 at any suitable time, for example as the passive arm is being moved.", "If it is determined, at decision block 1064, that the arm is being positioned, the process 1060 goes to block 1066 where a stiffness of the arm is set based on the arm's joint angle, referred to as “the angle α.” Next, the process 1060 can return to block 1064 to monitor whether the arm is continued to be positioned or whether a desired position is established and the arm therefore need to be “locked” at that position.", "As further shown in FIG.", "22, if it is determined, at decision block 1064, that the arm is not being positioned, the process 1060 proceeds to block 1068 where a stiffness of the arm is set (increased) such that the arm is “locked” and prevented from inadvertent movement.", "At the locked position, the arm can have a stiffness that is greater than the gravitational force and active loads applied thereto.", "As shown in FIG.", "22, the process 1060 can then end, at block 1070.However, it should be appreciated that the process 1060 can be performed continuously, such that, from block 1070, it can return to block 1064 to continue monitoring whether the arm is being positioned, as schematically shown in FIG.", "22.As mentioned above, various mechanisms can be used to a control the friction of a passive arm's joint, and the mechanisms are not limed to clutches.", "FIGS.", "23 and 24 illustrate an additional example of a mechanism that can be used to control and adjust a stiffness of an electromechanical arm 1080, such as a passive arm.", "The arm 1080 can include first and second segments 1080A, 1080B configured to move with respect to one another at a joint 1082 connecting them, along an axis 1083 extending through the joint 1082 as shown in FIG.", "23.A mechanism 1084 is disposed between the first and second arm segments 1080A, 1080B.", "In this example, the mechanism 1084, shown in FIG.", "24 at a cross-section along the axis 1083, is in the form of a spring-loaded, friction-based mechanism.", "As shown in FIG.", "24, surfaces of the portions of the segments 1080A, 1080B facing each other at the joint 1082 (as also shown in FIG.", "23) include surface features 1086a, 1086b, such as ratchet teeth, configured to engage with each other.", "However, the ratchet teeth are shown by way of example only, as the surface features can be similar to features of force-limiting mechanisms descried above and shown in FIGS.", "11, 12A, 12B, 13A, 13B, 14, 15, 16, and 17, or they can be any other surface features configured to releasably engage with each other.", "A screw 1088 having a shaft 1090 and heads 1092A, 1092B can be used to hold the first and second arm segments 1080A, 1080B such that the shaft 1090 extends through connecting bores formed through the segments 1080A, 1080B, and the heads 1092A, 1092B prevent the shaft 1090 from coming out of the bores.", "One or both of the heads 1092A, 1092B can be removably coupled to the shaft 1090.As shown in FIG.", "24, the mechanism 1084 can include a spring 1094, a portion of which is shown.", "The spring 1094 is configured to apply force to bring the segments 1080A, 1080B together at the joint 1082.One or both of the heads 1092A, 1092B can be configured to couple with an adjustment tool (e.g., a wrench or other tool) configured to tighten the spring 1094 to a desired degree of compression.", "The tighter the spring 1094 is clamped down, the higher the stiffness of the arm with respect to motion.", "It should be appreciated that the spring can be adjusted in a variety of other ways.", "For example, in other implementations, the spring can be tightened via a solenoid or any other component(s) that can apply a force to the spring.", "In such implementations, the amount of stiffness associated with the arm's segments can be automatically adjusted by the robotic surgical system controlling the resistance to arm motion.", "The adjustment can also be done based on user input.", "As an example, a solenoid-based control mechanism can be configured to be manually adjusted, for example, via an electrical dial, slider, or any other feature(s) that a user (e.g., the surgeon or surgical staff) can adjust based on user's preferences.", "In some embodiments, in addition to components described above, various other components can be used to control stiffness of a passive arm.", "For example, adjustable viscosity fluidic brakes (e.g., brakes based on magneto-rheological fluids) can be used.", "The arm stiffness can be adjusted by mechanically repositioning a magnetic field.", "For example, the friction of a joint of a passive arm can be adjustable using a fluidic break configured to position a magnetic field around the joint.", "Furthermore, although the techniques for controlling an electromechanical arm's stiffness are described in connection with a passive arm stiffness control, it should be appreciated that a stiffness in an electromechanical active arm can also be controlled as described above or using similar techniques and components.", "The devices disclosed herein can be designed to be disposed of after a single use, or they can be designed to be used multiple times.", "In either case, however, the device can be reconditioned for reuse after at least one use.", "Reconditioning can include any combination of the steps of disassembly of the device, followed by cleaning or replacement of particular pieces, and subsequent reassembly.", "In particular, the device can be disassembled, and any number of the particular pieces or parts of the device can be selectively replaced or removed in any combination.", "Upon cleaning and/or replacement of particular parts, the device can be reassembled for subsequent use either at a reconditioning facility, or by a surgical team immediately prior to a surgical procedure.", "Those skilled in the art will appreciate that reconditioning of a device can utilize a variety of techniques for disassembly, cleaning/replacement, and reassembly.", "Use of such techniques, and the resulting reconditioned device, are all within the scope of the present application.", "Preferably, the devices and components described herein will be processed before use.", "First, a new or used instrument is obtained and if necessary cleaned.", "The instrument can then be sterilized.", "In one sterilization technique, the instrument is placed in a closed and sealed container, such as a plastic or TYVEK bag.", "The container and instrument are then placed in a field of radiation that can penetrate the container, such as gamma radiation, x-rays, or high-energy electrons.", "The radiation kills bacteria on the instrument and in the container.", "The sterilized instrument can then be stored in the sterile container.", "The sealed container keeps the instrument sterile until it is opened in the medical facility.", "It is preferred that device is sterilized.", "This can be done by any number of ways known to those skilled in the art including beta or gamma radiation, ethylene oxide, steam, and a liquid bath (e.g., cold soak).", "An exemplary embodiment of sterilizing a device including internal circuitry is described in more detail in U.S. Pat.", "Pub.", "No.", "2009/0202387 filed Feb. 8, 2008 and entitled “System And Method Of Sterilizing An Implantable Medical Device.” It is preferred that device, if implanted, is hermetically sealed.", "This can be done by any number of ways known to those skilled in the art.", "One skilled in the art will appreciate further features and advantages of the described techniques based on the above-described embodiments.", "Accordingly, the present disclosure is not to be limited by what has been particularly shown and described, except as indicated by the appended claims.", "All publications and references cited herein are expressly incorporated herein by reference in their entirety." ] ]
Patent_15872637
[ [ "CAVITY AND QUANTUM COMPUTER", "According to one embodiment, a cavity with a cavity mode which is coupled to physical systems includes a spherical mirror and a plane mirror.", "The spherical mirror is provided at a birefringent crystal including the physical systems.", "The plane mirror is provided at the birefringent crystal opposite to the spherical mirror.", "The birefringent crystal has a first refractive index to light polarized in a first direction parallel to a polarization direction of the cavity mode on an optical axis of the cavity and a second refractive index to light polarized in a second direction parallel to the optical axis, the second refractive index being different from the first refractive index.", "A cavity length of the cavity and a mode waist radius of the cavity mode satisfy a specific condition." ], [ "1.A quantum computer comprising: a cavity including a solid medium including physical systems, the cavity having a cavity mode which resonates with the physical systems; a light source unit which irradiates the physical systems with operation light having a polarization direction crossing a wavefront of the cavity mode when the physical systems are coupled by the cavity mode; and a detector which detects a photon from the physical systems or from the cavity mode.", "2.The quantum computer according to claim 1, wherein the solid medium includes a first part where the physical systems are arranged and a second part different from the first part, the first part being smaller than the second part in a thickness in a traveling direction of the operation light.", "3.The quantum computer according to claim 1, further comprising: a first anti-reflective coating applied to a first surface of the solid medium on which the operation light is incident; a second anti-reflective coating applied to a second surface of the solid medium through which the operation light exits; and an optical trap or a light absorber arranged opposite to the second anti-reflective coating.", "4.The quantum computer according to claim 2, further comprising: a first anti-reflective coating applied to a first surface of the solid medium on which the operation light is incident; a second anti-reflective coating applied to a second surface of the solid medium through which the operation light exits; and an optical trap or a light absorber arranged opposite to the second anti-reflective coating.", "5.The quantum computer according to claim 1, wherein the physical systems are used as qubits.", "6.The quantum computer according to claim 1, wherein the photon is a photon lost from the physical systems or from the cavity mode.", "7.A quantum computer comprising: a cavity including a solid medium including a first part where physical systems are arranged and a second part different from the first part, the cavity having a cavity mode which resonates with the physical systems, the first part being smaller than the second part in a thickness in a traveling direction of operation light to manipulate the physical systems; a light source unit which irradiates the physical systems with the operation light when the physical systems are coupled by the cavity mode; and a detector which detects a photon from the physical systems or from the cavity mode.", "8.The quantum computer according to claim 7, further comprising: a first anti-reflective coating applied to a first surface of the solid medium on which the operation light is incident; a second anti-reflective coating applied to a second surface of the solid medium through which the operation light exits; and an optical trap or a light absorber arranged opposite to the second anti-reflective coating.", "9.The quantum computer according to claim 7, wherein the physical systems are used as qubits.", "10.The quantum computer according to claim 7, wherein the photon is a photon lost from the physical systems or from the cavity mode.", "11.A quantum computer comprising: a cavity including a solid medium including physical systems, the cavity having a cavity mode which resonates with the physical systems, the cavity further including a first anti-reflective coating applied to a first surface of the solid medium on which operation light to manipulate the physical systems is incident, a second anti-reflective coating applied to a second surface of the solid medium through which the operation light exits; an optical trap or a light absorber arranged opposite to the second anti-reflective coating; a light source unit which irradiates the physical systems with the operation light when the physical systems are coupled by the cavity mode; and a detector which detects a photon from the physical systems or from the cavity mode.", "12.The quantum computer according to claim 11, wherein the physical systems are used as qubits.", "13.The quantum computer according to claim 11, wherein the photon is a photon lost from the physical systems or from the cavity mode.", "14.A quantum calculation method comprising: providing a cavity including a solid medium including physical systems, the cavity having a cavity mode which resonates with the physical systems; irradiating the physical systems with operation light having a polarization direction crossing a wavefront of the cavity mode when the physical systems are coupled by the cavity mode; and detecting a photon from the physical systems or from the cavity mode.", "15.The quantum calculation method according to claim 14, wherein the solid medium includes a first part where the physical systems are arranged and a second part different from the first part, the first part being smaller than the second part in a thickness in a traveling direction of the operation light.", "16.The quantum calculation method according to claim 14, wherein a first anti-reflective coating is applied to a first surface of the solid medium on which the operation light is incident, and a second anti-reflective coating is applied to a second surface of the solid medium through which the operation light exits, and wherein the method further comprises providing an optical trap or a light absorber arranged opposite to the second anti-reflective coating.", "17.The quantum calculation method according to claim 15, wherein a first anti-reflective coating is applied to a first surface of the solid medium on which the operation light is incident, and a second anti-reflective coating is applied to a second surface of the solid medium through which the operation light exits, and wherein the method further comprises providing an optical trap or a light absorber arranged opposite to the second anti-reflective coating.", "18.A quantum calculation method comprising: providing a cavity including a solid medium including a first part where physical systems are arranged and a second part different from the first part, the cavity having a cavity mode which resonates with the physical systems, the first part being smaller than the second part in a thickness in a traveling direction of operation light to manipulate the physical systems; irradiating the physical systems with the operation light while the physical systems are coupled by the cavity mode; and detecting a photon from the physical systems or from the cavity mode.", "19.The quantum calculation method according to claim 18, wherein a first anti-reflective coating is applied to a first surface of the solid medium on which the operation light is incident, and a second anti-reflective coating is applied to a second surface of the solid medium through which the operation light exits, and wherein the method further comprises providing an optical trap or a light absorber arranged opposite to the second anti-reflective coating.", "20.A quantum calculation method comprising: providing a cavity including a solid medium including physical systems, the cavity having a cavity mode which resonates with the physical systems, a first anti-reflective coating being applied to a first surface of the solid medium on which operation light to manipulate the physical systems is incident, a second anti-reflective coating applied to a second surface of the solid medium through which the operation light exits; providing an optical trap or a light absorber arranged opposite to the second anti-reflective coating; irradiating the physical systems with the operation light when the physical systems are coupled by the cavity mode; and detecting a photon from the physical systems or from the cavity mode." ], [ "<SOH> BACKGROUND <EOH>In recent years, much effort has been made to research quantum computers based on coupling between a cavity and physical systems arranged in the cavity.", "In such a quantum computer, the physical systems which couple to a common cavity mode of the cavity are used as qubits (quantum bits).", "The quantum computer executes calculation by resonating the qubits with the common cavity mode to generate an interaction between the qubits, and in that state, optically manipulating the qubits.", "For the quantum computer, there has been a demand to increase the success probability of optical manipulation of the qubits referred to as quantum gate operation." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>FIG.", "1 is a sectional view depicting a cavity according to a first embodiment.", "FIG.", "2 is a perspective view depicting the cavity according to the first embodiment.", "FIG.", "3 is a diagram depicting an indicatrix.", "FIG.", "4 is a diagram illustrating the range of design parameters for the cavity according to the first embodiment.", "FIG.", "5 is a diagram illustrating the range of design parameters for the cavity according to the first embodiment.", "FIG.", "6 is a block diagram illustrating a quantum computer according to Example 2.FIGS.", "7A and 7B are a top view and a front view, respectively, depicting an example of a cavity according to a second embodiment.", "FIGS.", "8A and 8B are a top view and a front view, respectively, depicting another example of the cavity according to the second embodiment.", "FIGS.", "9A and 9B are a top view and a front view, respectively, depicting yet another example of the cavity according to the second embodiment.", "FIG.", "10 is a top view depicting another example of the cavity according to the second embodiment.", "FIGS.", "11A and 11B are a top view and a front view, respectively, depicting still another example of the cavity according to the second embodiment.", "FIGS.", "12A and 12B are a top view and a front view, respectively, illustrating a relation between a polarization direction of operation light and a wavefront of a cavity mode according to the second embodiment.", "FIGS.", "13A and 13B are a top view and a front view, respectively, illustrating the relation between the polarization direction of the operation light and the wavefront of the cavity mode according to the second embodiment.", "FIG.", "14 is a diagram illustrating a directional dependency of scattered light intensity.", "FIGS.", "15A and 15B are diagrams illustrating the orientations of crystal axes of a solid medium in a cavity according to Example 3.FIG.", "16 is a diagram illustrating the size of a mode generated in the solid medium depicted in FIGS.", "15A and 15B .", "FIG.", "17 is a diagram depicting a quantum computer according to a comparative example related to Example 3.FIG.", "18 is a perspective view depicting a cavity according to Example 3.FIG.", "19 is a diagram depicting a quantum computer according to Example 3.detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. application Ser.", "No.", "15/442,939, filed Feb. 27, 2017 which is based upon and claims the benefit of priority from Japanese Patent Application No.", "2016-130860, filed on Jun.", "30, 2016, the entire contents of which are incorporated herein by reference.", "FIELD Embodiments described herein relate generally to a cavity which couples to physical systems and a quantum computer using the cavity.", "BACKGROUND In recent years, much effort has been made to research quantum computers based on coupling between a cavity and physical systems arranged in the cavity.", "In such a quantum computer, the physical systems which couple to a common cavity mode of the cavity are used as qubits (quantum bits).", "The quantum computer executes calculation by resonating the qubits with the common cavity mode to generate an interaction between the qubits, and in that state, optically manipulating the qubits.", "For the quantum computer, there has been a demand to increase the success probability of optical manipulation of the qubits referred to as quantum gate operation.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a sectional view depicting a cavity according to a first embodiment.", "FIG.", "2 is a perspective view depicting the cavity according to the first embodiment.", "FIG.", "3 is a diagram depicting an indicatrix.", "FIG.", "4 is a diagram illustrating the range of design parameters for the cavity according to the first embodiment.", "FIG.", "5 is a diagram illustrating the range of design parameters for the cavity according to the first embodiment.", "FIG.", "6 is a block diagram illustrating a quantum computer according to Example 2.FIGS.", "7A and 7B are a top view and a front view, respectively, depicting an example of a cavity according to a second embodiment.", "FIGS.", "8A and 8B are a top view and a front view, respectively, depicting another example of the cavity according to the second embodiment.", "FIGS.", "9A and 9B are a top view and a front view, respectively, depicting yet another example of the cavity according to the second embodiment.", "FIG.", "10 is a top view depicting another example of the cavity according to the second embodiment.", "FIGS.", "11A and 11B are a top view and a front view, respectively, depicting still another example of the cavity according to the second embodiment.", "FIGS.", "12A and 12B are a top view and a front view, respectively, illustrating a relation between a polarization direction of operation light and a wavefront of a cavity mode according to the second embodiment.", "FIGS.", "13A and 13B are a top view and a front view, respectively, illustrating the relation between the polarization direction of the operation light and the wavefront of the cavity mode according to the second embodiment.", "FIG.", "14 is a diagram illustrating a directional dependency of scattered light intensity.", "FIGS.", "15A and 15B are diagrams illustrating the orientations of crystal axes of a solid medium in a cavity according to Example 3.FIG.", "16 is a diagram illustrating the size of a mode generated in the solid medium depicted in FIGS.", "15A and 15B.", "FIG.", "17 is a diagram depicting a quantum computer according to a comparative example related to Example 3.FIG.", "18 is a perspective view depicting a cavity according to Example 3.FIG.", "19 is a diagram depicting a quantum computer according to Example 3.DETAILED DESCRIPTION According to one embodiment, a cavity with a cavity mode which is coupled to physical systems includes a spherical mirror and a plane mirror.", "The spherical mirror is provided at a birefringent crystal including the physical systems.", "The plane mirror is provided at the birefringent crystal and is opposed to the spherical mirror.", "The birefringent crystal has a first refractive index to light polarized in a first direction parallel to a polarization direction of the cavity mode on an optical axis of the cavity and a second refractive index to light polarized in a second direction parallel to the optical axis, the second refractive index being different from the first refractive index.", "A following expression is satisfied: l1−<l<l<l1+ where l1−and l1+satisfy l 1 - 3 - ( 3  l R 5 l 0 2 + l R 2 - 3  l R 2 )  l 1 - - 3  l R 4  A 2  ω 2 = 0   and  l 1 + 3 - ( 3  l R 5 l 0 2 + l R 2 - 3  l R 2 )  l 1 + - 3  l R 4  A 2  ω 2 = 0 in which lRω2πn2/λ and l0=lRL/A, is a cavity length of the cavity, ω is a mode waist radius of the cavity mode, L is a total loss per one reciprocation in the cavity, A is a loss per one reciprocation in the cavity not dependent on the cavity length, nz is the second refractive index, and λ is a wavelength of light in the cavity mode.", "Hereinafter, embodiments will be described with reference to the drawings.", "In the following embodiments, like elements will be denoted by like reference symbols, and duplicate descriptions will basically be omitted.", "First Embodiment A quantum computer is known which includes a monolithic cavity including mirrors oppositely attached to a birefringent crystal.", "The quantum computer utilizes coupling between the cavity and physical systems arranged in the birefringent crystal.", "For such a cavity, efficient coupling between a cavity mode and the physical systems is desired.", "This can be achieved by reducing a cavity loss and a cavity relaxation rate (the rate at which energy of the cavity mode is lost per unit time).", "The cavity loss includes a loss resulting from coupling between modes (hereinafter referred to as a mode coupling loss).", "In the present embodiment, a technique for reducing the mode coupling loss will be described.", "When the quantum computer includes a cavity with efficient coupling between the cavity mode and the physical systems, it is possible to increase the success probability of quantum gate operation such as a quantum gate based on adiabatic passage.", "FIG.", "1 and FIG.", "2 are a sectional view and a perspective view, respectively, schematically depicting a cavity 10 according to a first embodiment.", "The cavity 10 is a monolithic Fabry-Perot cavity including a spherical mirror 12 attached to a surface 14 of birefringent crystal 11 and a plane mirror 13 attached to a surface 15 of the birefringent crystal 11 opposite to the spherical mirror 12, as depicted in FIG.", "1 and FIG.", "2.A radius of curvature of the spherical mirror 12 is represented as R in FIG.", "2.The birefringent crystal 11 includes therein physical systems (for example, atoms or ions) which couple to a common cavity mode of the cavity 10.In the present embodiment, a z-axis direction is defined as a direction parallel to an optical axis of the cavity 10, and x-axis direction is defined as a polarization direction of the common cavity mode, the polarization direction being on the optical axis of the cavity 10.The polarization direction refers to the direction of an electric field vector of light.", "In the birefringent crystal 11, a refractive index nX to light polarized in the x-axis direction (i.e., light with an electric light field parallel to the x-axis direction) is different from a refractive index nZ to light polarized in the z-axis direction.", "In the cavity 10, a mode waist is formed on the plane mirror 13.The mode waist refers to an area where the cavity mode has the smallest spot size.", "The present embodiment provides conditions for the cavity (cavity length and mode waist radius) under which a mode coupling loss occurring in the cavity 10 can be suppressed.", "First, the mode coupling loss in the birefringent crystal is formulated.", "The formulation includes (1) obtaining the refractive index of the birefringent crystal with respect to a wave number vector, (2) obtaining an electric field distribution of the cavity mode, (3) obtaining the spot size of the cavity mode and the radius of curvature of a wavefront of the cavity mode, and (4) obtaining a spatial distribution of the refractive index of the birefringent crystal and obtaining a mode coupling constant for a cavity length and a mode waist radius and a performance index of a computing element.", "Subsequently, based on the mode coupling loss formulated in accordance with the above-described procedure, (5) a condition is obtained under which the mode coupling loss is suppressed to enable high computing element performance to be achieved, (1) Refractive-Index Distribution (Wave Number Distribution) In the birefringent crystal, the refractive index varies depending on the polarization direction and thus on a wave number vector.", "Thus, the refractive index with respect to any wave number vector is formulated.", "An indicatrix 30 in a coordinate system illustrated in FIG.", "3 is expressed as follows.", "x 2 n x 2 + y 2 n y 2 + z 2 n z 2 = 1 When the wave number vector is represented as {right arrow over (k)}=(kx, ky, kz)t the refractive index is represented by the major diameter and minor diameter of a sectional ellipse cut out from the indicatrix at a plane perpendicular to the wave number vector.", "The sectional ellipse is expressed as follows based on polar coordinate indication.", "{right arrow over (A)}(Φ)=(nx cos θcos Φ,nycos θsin Φ,nz sin θ) In the expression, θ is a function dependent on φ.", "When the plane perpendicular to the wave number vector is represented as {right arrow over (S)}(s, y, z), the following expression holds true because {right arrow over (k)}·{right arrow over (S)}=0.kxx+kyy+kzz=0 The sectional ellipse {right arrow over (A)} lies on the plane {right arrow over (S)}, and thus the following expression holds true.", "kxnxθcos Φ+kynycos θsin Φ+kznzsin θ=0 From this expression/ the following expression in which θ is expressed by a function of Φ is obtained.", "tan   θ = - k x  n x  cos   ϕ + k y  n y  sin   ϕ k z  n z A distance r from the origin of the sectional ellipse is expressed as follows using θ. r ( k → , ϕ ) = ( n x  n z  k z  cos   ϕ ) 2 + ( n y  n z  k z  sin   ϕ ) 2 + n b 2  ( k x  n x  cos   ϕ + k y  n y  sin   ϕ ) 2 ( k x  n x  cos   ϕ + k y  n y  sin   ϕ ) 2 + ( k z  n z ) 2 When Φ where r takes the maximum value is designated as Φ1 and Φ where r takes the minimum value is designated as Φ2, an intrinsic refractive index is represented as nj({right arrow over (k)})=r({right arrow over (k)},Φj) (j=1, 2).", "The wave number (the magnitude of the wave number vector) corresponding to each intrinsic refractive index is represented as k j = 2  π λ  n j  ( k → ) , where λ denotes the wavelength of light in the cavity mode.", "The wave number also satisfies kj=√{square root over (kx2+ky2+kz2)}, and thus, deletion of kx or ky allows the wave number kj to be expressed as a function of ky or kx and kz.", "When Φ1 and Φ2 are approximated as Φ1=π/2 and Φ2=0, the intrinsic refractive index is expressed as follows.", "n 1  ( k x , k z ) = n x  { 1 + 1 2  ( 1 - n x 2 n z 2 )  k x 2 k z 2 } n 2  ( k y , k z ) = n y  { 1 + 1 2  ( 1 - n y 2 n z 2 )  k y 2 k z 2 } (2) Formulation of Electric Field Distribution of the Cavity Mode Using the formulated relation between the refractive index and the wave number, an electric field distribution of the cavity mode is expressed by the following integral (Fresnel-Kirchhoff's diffraction integral).", "{right arrow over (E)}j(x, y, z)=∫∫dkxdky{right arrow over (A)}j(kx, ky)exp [ikxx+iky+i√{square root over (kj2(kx, ky)−kx2−ky2z)}]E0(kx, ky) In this expression, E0(kx, ky) represents an electric field distribution in a wave number vector space at the position of the mode waist (z=0), and E 0  ( k x , k y ) ≡ exp [ - k x 2  ω x 2 + k y 2  ω y 2 4 ] .", "{right arrow over (A)}j(kxky) represents a vector representing a minor axis direction or a major axis direction of the sectional ellipse, and corresponds to the polarization direction of an electric field.", "To perform the integration, a coefficient of z in an exponent part is expanded, to a second order of kx and ky.", "Such, approximation is appropriate because the direction of the wave number vector near the optical axis of the cavity mode is similar to the z-axis direction and because kx and ky are small compared to the wave number.", "The electric field distribution of the cavity mode expanded to the second order of kx and ky is as follows.", "E j →  ( x , y , z ) = ∫  ∫  dk x  dk y  A j →  exp [ ik x  x + ik y  y + i  ( B j + C j  k x 2 + D j  k y 2 )  z - k x 2  ω x 2 + k y 2  ω y 2 4 ]  B 1 = 2  π λ  n x , B 2 = 2  π λ  n y , C 1 = - λ   n x 4  π   n x 2 , C 2 = - λ 4  π   n y ,   D 1 = - λ 4  π   n x , D 2 = - λ   n y 4  π   n z 2 The electric field distribution of the cavity mode is obtained as follows using an integral formula ∫ exp  ( - α   x 2 - β   x )  dx = π α  exp ( β 4  α ) · E j →  ( x , y , z ) = π   A 1 ( ω x 2 + i   λ π  n x n z 2  z )  ( ω y 2 + i  λ π   n y  z )  exp [ - x 2 ( ω x 2 4 + i  λ 4  π  n x n z 2  z ) - y 2 ( ω y 2 4 + i  λ 4  π   n y  z ) - i  2  π λ  n x  z ] (3) Formulation of the Spot Size and the Radius of Curvature, of the Wavefront Based on the electric field distribution of the cavity mode, the spot size of the mode and the radius of curvature at each point on the z axis (optical axis) are obtained.", "The following express relations between X2 terms and y2 terms in a mode j and spot sizes and ωjx and ωjy and the radii of curvature of the wavefront Rjx and Rjy.", "Real part of x2 in the mode j = - x 2 ω jx 2  ( z ) Real part of y2 in the mode j = - y 2 ω jy 2  ( z ) Imaginary part of x2 in the mode j = - π   n x  x 2 λ   R jx 2  ( z ) Imaginary part of y2 in the mode j = - π   n y  y 2 λ   R jy 2  ( z ) Therefore, the spot sizes and the radii of curvature of the wavefront are expressed as follows.", "ω 1  x 2  ( z ) = ω x 2 [ 1 + ( n x 2  z n z 2  z 1  y ) 2 ] R 1  x  ( z ) = n x 2 n z 2  z [ 1 + ( n z 2  z 1  x n x 2  z ) 2 ] ω 1  y 2  ( z ) = ω y 2 [ 1 + ( z z 1  y ) 2 ] R 1  y  ( z ) = z [ 1 + ( z 1  y z ) 2 ] ω 2  x 2  ( z ) = ω x 2 [ 1 + ( z z 2  x ) 2 ] R 2  x  ( z ) = z [ 1 + ( z 2  x z ) 2 ] ω 2  y 2  ( z ) = ω y 2 [ 1 + ( n y 2  z n z 2  z 2  y ) 2 ] R 2  y  ( z ) = n y 2 n z 2  z [ 1 + ( n z 2  z 2  y n y 2  z ) 2 ] In the expressions, z jx = π λ  n j  ω jx 2   and   z jy = π λ  n j  ω jy 2 are Rayleigh lengths.", "ωjx is the waist size in the mode j in the x-axis direction, and ωjy is the waist size in the mode j in the y-axis direction.", "(4) Refractive Index Distribution (Spatial Distribution), the Performance Indices of the Mode Coupling Constant and the Computing Element A cavity formed of a birefringent medium involves a refractive index distribution formed in the medium in accordance with its cavity mode.", "The presence of such a refractive index distribution causes spatial modes (transverse modes) of polarized light beams to be coupled together.", "Thus, a coupling constant and a mode coupling loss are obtained for a case where a fundamental mode couples to an infinite number of higher modes.", "The performance index of a quantum computing element based on such a cavity is formulated.", "The coupling constant of mode coupling is proportional to a value resulting from integration, over the entire space, of the product of a refractive index distribution nj(x, y, z) and an electric field intensity E (x, y, z).", "At this time, since an infinite number of higher modes are assumed to be present which couples to the fundamental mode, an effective coupling constant representing the sum of all the higher modes coupled together is not dependent on the type or number of the higher modes coupled together.", "The refractive index, distributions in the x- and y-axis distributions are expressed by the same function with different widths for each z due to the properties of Gaussian beams.", "Therefore, determination of a refractive index distribution nsi(z) on the spot size for each z allows the coupling constant to be determined as follows.", "gi(ωxl)∝∫∫∫ δni(z, y, z)E(x, y, z)dxdydx δ ∫0lδnsi(z)dz In the expression, ni(x, y, z)=ni+δni(x, y, z) and nsi(z)=ni+δnsi(z), and l is a cavity length.", "A loss resulting from the mode coupling of polarization modes is considered to be proportional to the coupling constant (L1 ∝g1, L2∝g2).", "The spatial distribution of the refractive index at each position can be obtained from ky/kz and kx/kz of the wave number vector.", "The inclination of a tangent of a curve connecting the spot sizes for each z in a plane with x=0 is designated as ky/kz on the spot size for each z.", "The inclination of a tangent to a curve connecting the spot sizes for each z in a plane with y=0 is designated as kx/kz n the spot size for each z.", "These values are obtained by differentiating ω1x(z), etc.", "with respect to z.", "Based on ky/kz and kx/kz thus obtained, the spatial distribution of the refractive index on the spot can be obtained as follows.", "n x + δ   n s   1  ( z ) = n x + 1 2  n x ( 1 - n x 2 n z 2 )  z 2 z 2 + n z 2 n x 2  z 1  x 2  ω x 2  n x 2 z 1  x 2  n z 2 n y + δ   n s   2  ( z ) = n y + 1 2  n y ( 1 - n y 2 n z 2 )  z 2 z 2 + z 2  y 2  ω y 2 z 2  y 2 Such a refractive index distribution leads to coupling of modes.", "The relevant coupling constant is obtained as follows.", "g 1  ( ω x , l ) ∝ 1 2  n x ( 1 - n x 2 n z 2 ) [ l - n z n x  z 1  x  arctan ( l   n x z 1  x  n z ) ]  ( ω x  n x 2 z 1  x  n z 2 ) 2 g 2  ( ω y , l ) ∝ 1 2  n y ( 1 - n y 2 n z 2 ) [ l - z 2  y  arctan ( l z 2  y ) ]  ( ω y z 2  y ) 2 Now, when the sum of the loss per cavity length other than the mode coupling loss and the transmissivity of the mirrors is represented as f(l), the loss to the cavity per cavity length is expressed as follows.", "L 1  ( ω x , l ) = L 0  [ l - n z n x  z 1  x  arctan  ( ln x z 1  x  n z ) ]  ( ω x z 1  x ) 2 + f  ( l )   L 2  ( ω y , l ) = L 0  [ l - z 2  y  arctan  ( l z 2  y ) ]  ( ω y z 2  y ) 2 + f  ( l ) In the expression, L0 is a coefficient incorporating all proportionality coefficients for the mode coupling.", "Cavity relaxation rates κ1κ2 for the respective polarization modes are expressed as follows.", "κ 1  ( ω x , l ) = cL 1  ( ω x , l ) 2   π   n x  l = c 2   π   n x  l  { L 0  [ l - n z n x  z 1  x  arctan  ( ln x z 1  x  n z ) ]  ( ω x z 1  x ) 2 + f  ( l ) } κ 2  ( ω x , l ) = cL 2  ( ω y , l ) 2   π   n y  l = c 2   π   n y  l  { L 0  [ l - z 2  y  arctan  ( l z 2  y ) ]  ( ω y z 2  y ) 2 + f  ( l ) } A performance index nai determining the performance of the cavity as a element can be expressed as follows.", "nai≡κiγ/g2∝κi(ωx, l)ω2 A smaller value of the performance index is indicative of higher performance of the computing element.", "The performance index nai is expressed as follows using κ1κ2.n a   1 = c 1  z 1  x l  { L 0  [ l - n z n x  z 1  x  arctan  ( ln x z 1  x  n z ) ]  ( ω x z 1  x ) 2 + f  ( l ) } n a   2 = c 2  z 2  y l  { L 0  [ l - z 2  y  arctan  ( l z 2  y ) ]  ( ω y z 2  y ) 2 + f  ( l ) } In the expressions, ci is a constant incorporating all of the coefficients of γ and g with respect to ω2, coefficients of κi, etc.", "(5) Conditions for Suppressing the Loss and Achieving High Computing Element Performance Based on the expression of the performance index nai for the cavity thus obtained, conditions are examined under which the loss can be suppressed to enable the performance of the cavity as a computing element to be enhanced.", "First, a condition is examined under which the optimal computing element performance is achieved when the loss other than the mode coupling loss does not depend on the cavity length (f((l)=AL0), where A represents a loss per one reciprocation in the cavity not dependent on the cavity length.", "In this case, nai is expressed as follows.", "n a   1 = c 1  z 1  x l  { L 0  [ l - n z n x  z 1  x  arctan  ( ln x z 1  x  n z ) ]  ( ω x z 1  x ) 2 + AL 0 } n a   2 = c 2  z 2  y l  { L 0  [ l - z 2  y  arctan  ( l z 2  y ) ]  ( ω y z 2  y ) 2 + AL 0 } These expressions are differentiated to allow the optimal cavity length l to be expressed as follows.", "lA L = ω 2  π   n z λ In the expression, L is the total loss per one reciprocation in the cavity.", "This optimal structure corresponds to a minimum in a graph illustrated in FIG.", "4.The cavity length at which the performance index nai takes the minimum is represented as l0.In this optimal structure, the loss resulting from the mode coupling is suppressed to allow the performance index nai to take the minimum.", "The effect of the inter-mode coupling is assumed to be significant, making the performance index nai double the minimum.", "Then, when the minimum of nai is represented as nai min, a cavity length l1 which nai=2nai min satisfies the following relation.", "l 1 3 = ( 3  l R 5 l 0 2 + l R 2 - 3  l R 2 )  l 1 - 3  l R 4  A 2   ω 2 = 0 When two of the solutions satisfying this formula are assumed to be l1+, l1−(l1+>l1−), then in a structure that suppresses the loss resulting from the inter-mode coupling, the cavity length l may satisfy the following relation.", "l1−<l<l1+ As is apparent from FIG.", "4, when the cavity length ranges from the half of the optimal cavity length l0 to the double of the optimal cavity length (0.510≤1≤210), the performance index nai varies insignificantly, that is, the loss resulting from the inter-mode coupling, is effectively suppressed.", "Therefore, the cavity may be designed so as to satisfy 0.510≤1≤210.A condition is also examined under which the optimal computing element performance is achieved when the loss other than the mode coupling loss is proportional to the cavity length (f(l)=BlL0), where B represents a loss per one reciprocation in the cavity proportional to the cavity length.", "In this case, nai is expressed as follows.", "n a   1 = c 1  z 1  x l  { L 0  [ l - n z n x  z 1  x  arctan  ( ln x z 1  x  n z ) ]  ( ω x z 1  x ) 2 + BlL 0 } n a   2 = c 2  z 2  y l  { L 0  [ l - z 2  y  arctan  ( l z 2  y ) ]  ( ω y z 2  y ) 2 + BlL 0 } The expressions are differentiated to allow the cavity length to be expressed as follows.", "Bl L = arctan  ( l l R ) - ll R l R 2 + l 2 In the expression, represents a Rayleigh length, lR=ω2πnx/λ.", "This optimal structure corresponds to the minimum of the graph in FIG.", "5.The optimal Rayleigh length is represented as lRO.", "In this optimal structure, the loss resulting from the mode coupling is suppressed to allow nai to take the minimum.", "The effect of the inter-mode coupling is assumed to be significant to make nai double the minimum.", "When the minimum of nai is represented as nai min, the Rayleigh length lR1 at which nai=2na min satisfies the following relation.", "l R   1 = l R   0 + δ δ = - ( l 2 + l R   0 2 )  ( 2 + Bl R   0 ) ± ( l 2 + l R   0 2 ) 2  ( 2 + Bl R   0 ) 2 - 4  l R   0  l  [ B [ l 2 + l R   0 2 ) + l R   0 ] 2  [ B  ( l 2 + l R   0 2 ) + l R   0 ] Therefore, in the structure that suppresses the loss resulting from the inter-mode coupling, the Rayleigh length lR may satisfy the following relation.", "l R   0 - ( l 2 + l R   0 2 )  ( 2 + Bl R   0 ) - ( l 2 + l R   0 2 ) 2  ( 2 + Bl R   0 ) 2 - 4  l R   0  l  [ B [ l 2 + l R   0 2 ) + l R   0 ] 2  [ B  ( l 2 + l R   0 2 ) + l R   0 ] < I R < l R   0 - ( l 2 + l R   0 2 )  ( 2 + Bl R   0 ) + ( l 2 + l R   0 2 ) 2  ( 2 + Bl R   0 ) 2 - 4  l R   0  l  [ B [ l 2 + l R   0 2 ) + l R   0 ] 2  [ B  ( l 2 + l R   0 2 ) + l R   0 ] Even when the cavity length 1 ranges from the half of the optimal cavity length 10 to the double of the optimal cavity length (0.510≤1≤210), the loss resulting from the inter-mode coupling is effectively suppressed.", "Therefore, the cavity may be designed so as to satisfy 0.510≤1≤210.Such a condition can be determined using a method similar to the above-described method even when the loss other than the mode coupling loss is expressed by a more general function.", "The above-described example is illustrative, and the condition for suppressing the loss of the cavity mode of the cavity attached to the birefringent crystal can be obtained by formulating the mode coupling loss using the above-described analysis technique for various cavities.", "EXAMPLE 1 In Example 1, an example of the cavity will be described in which the loss other than the mode coupling loss is not dependent on the cavity length.", "As depicted in FIG.", "1, the cavity in Example 1 is a monolithic Fabry-Perot cavity including a Y2SiO5 crystal into which Pr3+ ions are doped (Pr:YSO) as the birefringent crystal 11, the spherical mirror 12 arranged on the surface 14 of the Y2SiO5 crystal, and the plane mirror 13 arranged on the surface 15 of the Y2SiO5 crystal.", "The spherical mirror 12 and the plane mirror 13 are arranged such that the b axis of the crystal axes (b axis, D1 axis, D2 axis) of the Y2SiO5 crystal is parallel to the optical axis (z axis) of the cavity.", "The spherical mirror 12 and the plane mirror 13 are used such that the polarization direction (x-axis direction) of the cavity mode on the optical axis is parallel to the D2-axis direction.", "When light is assumed to have a wavelength of 606 nm, a refractive index to light polarized in the D2-axis direction is approximately 1.81, and a refractive index light polarized in the b-axis direction is approximately 1.79.The spherical mirror 12 is produced by polishing the surface 14 of the Y2SiO5 crystal so as to set the radius of curvature R to 2.000 mm and forming a dielectric multilayer film on the polished surface 14.The Y2SiO5 crystal is processed so as to set the cavity length to 0.173 mm.", "The plane mirror 13 is produced by forming a dielectric multilayer film on the surface 15 subjected to surface polishing.", "This results in a mode waist radius of 5 μm.", "The thus processed cavity satisfies the condition for suppressing the mode coupling loss when, for example, the loss AL0 on the spherical mirror 12 is approximately 0.01% and the loss BlL0 in the birefringent crystal is negligible.", "The thus processed cavity also satisfies the condition for suppressing the mode coupling loss even when, for example, the loss BlL0 in the birefringent crystal is approximately 0.01% and the loss AL0 on the spherical mirror 12 is negligible.", "Therefore, the cavity according to Example 1 allows the mode coupling loss to be suppressed.", "EXAMPLE 2 In Example 2, a quantum computer utilizing the cavity according to the first embodiment will be described.", "FIG.", "6 schematically illustrates the quantum computer according to Example 2.The quantum computer illustrated in FIG.", "6 includes the cavity 10 depicted in FIG.", "1.The cavity 10 includes a Pr3+:Y2SiO5 crystal corresponding to the birefringent crystal 11.The cavity 10 is arranged in a cryostat 68 so as to be kept at low temperature (for example, 4K).", "The quantum computer further includes a light source apparatus which generates operation light to manipulate physical systems used as qubits and which irradiates the physical systems with the operation light.", "The light source apparatus includes a semiconductor laser 60, a beam splitter 61, a mirror 62, acousto-optic modulators 63 and 64, mirrors 65 and 66, a lens 67, and a controller 69.Laser light output from the semiconductor laser 60 is split into two portions by the beam splitter 61.One of the laser light beams resulting from the splitting enters the acousto-optic modulator 63, while the other laser light beam is reflected by the mirror 62 to enter the acousto-optic modulator 64.The acousto-optic modulators 63 and 64 modulate the frequency and intensity of the laser light in accordance with control signals generated by the controller 69.The laser light beam modulated by the acousto-optic modulator 63 is guided by the mirrors 65, 66 and the lens 67 so as to be radiated to the cavity 10.The laser light beam modulated by the acousto-optic modulator 63 is guided by the lens 67 so as to be radiated to the cavity 10.The quantum computer can execute a quantum gate by selectively manipulating two qubits through irradiation with the two laser light beams.", "The quantum computer according to Example 2 performs quantum gate operation using the cavity in which the cavity mode of the cavity efficiently couples to the physical systems included in the birefringent crystal.", "This enables an increase in the success probability of the quantum gate operation.", "Second Embodiment For a quantum computer which optically manipulates physical systems used as qubits and in which the physical systems resonate with the common cavity mode to interact with one another, a method is known which suppresses the adverse effect of an error in quantum gate operation on information processing when the error results from a particular cause.", "The error in quantum gate operation corresponds to a difference between an actual quantum state of the qubits resulting from quantum gate operation and a quantum state of the qubits that is expected to be established as a result of the quantum gate operation.", "For example, a conditioned quantum gate which varies the quantum state of one qubit according to the quantum state of another qubit or a quantum gate referred to as a two-quantum-bit gate is executed by adiabatic passage using operation light.", "At this time, a photon may be lost due to spontaneous emission from the physical systems used as the qubits, or a photon may be lost which are in a cavity mode needed to allow the physical systems used as the qubits to interact with each other.", "This results in such an error.", "The photon lost in this manner is referred to as a lost photon.", "In these cases, the quantum computer is configured to detect a lost photon while executing quantum gate operation for error correction, and adopts information processing results produced when no lost photon is detected.", "This allows efficient suppression of the adverse effect of the error on information processing.", "In cases where the qubits are arranged in the solid medium, operation light may be scattered in the solid medium or at an interface between the outside and the solid medium.", "Then, scattered light which is more intense than the lost photon may reach a photodetector, making the scattered light resulting from the operation light difficult to distinguish from the lost photon.", "Therefore, the lost photon is precluded from being correctly detected.", "Thus, even if the lost photon is not actually lost, the information processing results may be discarded because of the scattered light.", "That is, the quantum gate operation may be considered to have failed.", "In the second embodiment, a technique provided which allows, when the physical systems in the solid medium are utilized as qubits, a lost photon to be correctly detected while avoiding the adverse effect of scattering of the operation light allowing the qubits to be manipulated.", "FIGS.", "7A and 7B are a top view and a front view, respectively, schematically depicting a cavity 70 in one example used for a quantum computer according to the second embodiment.", "As depicted in FIGS.", "7A and 7B, the cavity 70 includes a solid medium 71, a spherical mirror 72 attached to the solid medium 71, and a spherical mirror 73 attached to the solid medium 71 opposite to the spherical mirror 72.The solid medium 71 includes therein physical systems which resonate with the common cavity mode of the cavity 70.The solid medium 71 has parts different in thickness in a traveling direction of operation light used to manipulate the physical systems used as qubits.", "The thickness hereinafter refers to the thickness in the traveling direction of the operation light unless otherwise specified.", "In FIG.", "7A, the operation light travels from an incident surface 77 to an emitting surface 78.The solid medium 71 has a thin part 74, thick parts 76 adjacent to the spherical mirrors 72 and 73, respectively, and parts 75 each extending in a tapered manner between the part 74 and the part 76.The physical systems positioned in the part 74 are utilized as qubits.", "A part of the surface of the part 74 is irradiated with the operation light.", "The part 74 is hereinafter referred to as the irradiated part.", "The operation light is emitted from such a light source apparatus as depicted in FIG.", "6.The physical systems used as the qubits resonate with the common cavity mode and perform an interaction needed for the two-quantum-bit gate, via a photon present in the cavity mode.", "The solid medium 71 is partly thinned to the extent that the effect on the lifetime of the photon of the cavity mode is prevented from hindering execution of the two-quantum-bit gate.", "The total amount of scattered light generated inside the solid medium 71 by the operation light is substantially proportional to the length of an optical path of the operation light inside the solid medium 71 when the solid medium 71 is a common uniform transparent medium and the total amount of scattered light corresponds to a very small portion of the incident light (for example, 10% or less).", "The solid medium 71 may be such a transparent medium.", "The solid medium 71 is formed to make the irradiated part 74 thinner than the neighbor parts 75 and 76 so as to set a short optical path of the operation light inside the solid medium 71.This enables a reduction in possible scattered light.", "FIGS.", "8A and 8B are a top view and a front view, respectively, schematically depicting a cavity 80 in another example used for a quantum computer according to the second embodiment.", "As depicted in FIGS.", "8A and 8B, the cavity 80 includes a solid medium 81, a spherical mirror 82 attached to the solid medium 81, and a plane mirror 83 attached to the solid medium 81 opposite to the spherical mirror 82.The solid medium 81 includes therein physical systems which resonate with the common cavity mode of the cavity 80.The solid medium 81 has a thin irradiated part 84 adjacent to the plane mirror 83, a thick part 86 adjacent to the spherical mirror 82, and a part 85 extending in a tapered manner between the part 84 and the part 86.FIGS.", "9A and 9B are a top view and a front view, respectively, schematically depicting a cavity 90 in another example used for a quantum computer according to the second embodiment.", "The cavity 90 depicted in FIGS.", "9A and 9B is toroidal or disc-shaped cavity having a cavity mode referred to as a whispering gallery mode.", "The cavity 90 includes a disc-shaped solid medium 91.A tapered optical fiber (not depicted in the drawings) for light input and output is connected to the solid medium 91.The solid medium 91 includes therein physical systems which resonate with the common cavity mode of the cavity 90.The cavity mode is present inside the solid medium 91 along a periphery of the solid medium 91.The solid medium 91 includes a thin irradiated part 94 extending along the periphery and a thick part 95 positioned inside the irradiated part 94.FIG.", "10 is a top view schematically depicting a cavity 100 in another example used for a quantum computer according to the second embodiment.", "As depicted in FIG.", "10, the cavity 100 includes a solid medium 101 and spherical mirrors 102, 103 and 104 attached to the solid medium 101.The solid medium 101 includes therein physical systems which resonate with the common cavity mode of the cavity 100.The cavity mode is present between the spherical mirror 102 and the spherical mirror 103, between the spherical mirror 103 and the spherical mirror 104, and between the spherical mirror 102 and the spherical mirror 104.The irradiated part 105 of the solid medium 101 is formed to be thinner than other neighbor parts.", "The cavity 80 depicted in FIGS.", "8A and 8B, the cavity depicted in FIGS.", "9A and 9B, and the cavity 100 depicted in FIG.", "10 are each shaped to set a short optic path of the operation light inside the solid medium, like the cavity 70 depicted in FIGS.", "7A and 7B.", "This enables a reduction in possible scattered light.", "As described below, additional scattered light may be generated.", "In the cavity 70 depicted in FIG.", "7, the operation light enters the solid medium 71 through the incident surface 77, passes through the solid medium 71, and exits the solid medium 71 through the emitting surface 78.At this time, a portion of the operation light is reflected by the emitting surface 78 and passes through the solid medium 71 again.", "In this case, the reflected light from the emitting surface 78 may cause the generation of additional scattered light inside the solid medium 71.When the reflected light reaches the incident surface 77, most of the reflected light exits the solid medium 71 through the incident surface 77, while a portion of the reflected light is reflected by the incident surface 77 and passes through the solid medium 71 again.", "The reflected light from the incident surface 77 may cause the generation of additional scattered light inside the solid medium 71.Furthermore, the operation light having exited through the emitting surface 73 may, for example, be reflected by any object and enter the solid medium 71 again.", "The operation light having entered the solid medium 71 may cause the generation of additional scattered light inside the solid medium 71 again.", "A mechanism will be described which prevents additional scattered light from being generated as described above.", "FIGS.", "11A and 11B are a top view and a front view, respectively, schematically depicting a cavity 110 in another example used for a quantum computer according to the second embodiment.", "As depicted in FIGS.", "11A and 11B, the cavity 110 includes the solid medium 71, the spherical mirrors 72 and 73 attached to the solid medium 71 opposite to each other, an anti-reflective coating 111 applied to the incident surface 77 of the irradiated part 74, an anti-reflective coating 112 applied to the emitting surface 78 of the irradiated part 74, and an optical trap 113 provided opposite to the anti-reflective coating 112.The optical trap 113 is installed beyond the anti-reflective coating 112 in the traveling direction of the operation light.", "The solid medium 71 is not limited to the example where the irradiated part 74 is shaped to be thinner than the neighbor parts 75 and 76 as depicted in FIG.", "11A but may be configured such that the irradiated part 74 has the same thickness as that of the other parts 75 and 76, for example, as in the cavity 10 depicted in FIG.", "2.The anti-reflective coatings 111 and 112 prevent internal reflection.", "Specifically, the anti-reflective coating 112 prevents the operation light traveling through the solid medium 71 from being reflected by the emitting surface 78.The provision of the anti-reflective coating 112 reduces the operation light reflected by the emitting surface 78.The anti-reflective coating 111 prevents the operation light traveling through the solid medium 71 after being reflected by the emitting surface 78 from being reflected by the incident surface 77.The provision of the anti-reflective coating 111 reduces the operation light reflected by the incident surface 77.In the example illustrated in FIGS.", "11A and 11B, the anti-reflective coating is applied both to the incident surface 77 and to the emitting surface 78.However, the areas to which the anti-reflective coating is applied are not limited to the areas in this example.", "For example, the anti-reflective coating may be applied to at least one of the incident surface 77 and the emitting surface 78.Preferably, the anti-reflective coating may be applied to the emitting surface 78.The anti-reflective coating may be applied to areas other than the incident surface 77 and the emitting surface 78.The optical trap 113 traps the operation light transmitted through the solid medium 71.The provision of the optical trap 113 prevents the operation light transmitted through the solid medium 71 from entering the solid medium 71 again.", "Instead of the optical trap 113, an optical absorber may be used.", "The anti-reflective coating and the optical trap 113 or the optical absorber may be applied to other cavities such as the cavity 80 depicted in FIGS.", "8A and 8B, the cavity 90 depicted in FIGS.", "9A and 9B, and the cavity 100 depicted in FIG.", "10.As described above, the anti-reflective coatings 111, 112, and the optical trap 113 prevent multiple reflections of the operation light inside the solid medium 71 and causing the generation of scattered light.", "The anti-reflective coatings 111, 112, and the optical trap 113 further prevent the operation light having temporarily exited the solid medium 71 from being returned into the solid medium 71 and causing the generation of scattered light, and also prevent the operation light having exited the solid medium 71 from reaching a certain scatterer and thus causing the generation of scattered light.", "As a result, the scattered light can he prevented from reaching the photodetector which detects a lost photon.", "Moreover, upon reaching the incident surface 77 or the emitting surface 78, the scattered light generated in the solid medium 71 can be prevented from returning into the solid medium 71 after being reflected by the incident surface 77 or the emitting surface 73.In the present embodiment, the polarization direction of the operation light can be set to coincide with a direction which crosses (for example, is orthogonal to) the wavefront of the cavity mode.", "The polarization direction points to the direction of an electric field vector of light.", "FIGS.", "12A and 12B depict the Fabry-Perot cavity 70 depicted in FIGS.", "7A and 7B and in which the polarization direction of the operation light is set to coincide with a direction orthogonal to the wavefront of the cavity mode.", "FIGS.", "13A and 13B depict a cavity 130 which is similar to the cavity 90 depicted in FIGS.", "9A and 9B and in which the polarization direction of the operation light is set to coincide with a direction orthogonal to the wavefront of the cavity mode.", "In a solid medium 131 in the cavity 130, the irradiated part has the same thickness as that of the neighbor parts.", "When the polarization direction of the operation light is orthogonal to the wavefront of the cavity mode, scattered light is less likely to be generated in the direction orthogonal to the wavefront of the cavity mode.", "The reason will be described below.", "A lost photon is assumed to be lost mostly through an input/output element for light in the cavity mode and light outside of the cavity.", "For example, for the Fabry-Perot cavity, a lost photon is lost through the mirror (for example, the spherical mirror 72 or the spherical mirror 73) included in the cavity.", "For the toroidal or disc-shaped cavity, a lost photon is lost through the tapered optical fiber for input and output.", "In these cases, a spatial mode (the area where the lost photon is present and the direction in which the lost photon travels) outside the cavity mode for the lost photon traveling from the cavity mode to the outside of the solid medium is evidently known, and a photodetector or a photon detector is arranged in association with the spatial mode.", "That is, the photodetector or the photon detector is considered to be arranged near the mirror included in the cavity, or at an end surface of the I/O tapered optical fiber.", "At this time, when the polarization direction of the operation light is set to be orthogonal to the wavefront of the cavity mode, it is possible to significantly reduce the possibility that the photodetector is reached by a photon that is not the lost photon, that is, scattered light generated by the effect of the operation light.", "Next, the reason why scattered light is less likely to be generated in the direction orthogonal to the wavefront of the cavity mode when the polarization direction of the operation light is orthogonal to the wavefront of the cavity mode will be explained.", "When the scatterer is irradiated with light to generate scattered light, an intensity distribution of the scattered light depends significantly on the traveling direction and polarization direction of irradiation light.", "The dependency will be described with reference to FIG.", "14.As illustrated in FIG.", "14, the irradiation light traveling in the z-axis direction is assumed to have an electric field vector oscillating in the y-axis direction.", "When the irradiation light is scattered into scattered light by the scatterer, the direction of a dipole moment induced by the scatterer is also the y-axis direction.", "Electromagnetic waves radiated from the dipole moment are scattered light.", "The intensity of the scattered light in a far field is high for scattered light traveling in the z-axis direction and in the x-axis direction, and is low for scattered light traveling in the y axis direction.", "When the angle between the y-axis direction and a direction from the scatterer toward an observation point where the intensity of scattered light is observed is represented as θ, the intensity (power) per unit solid angle is proportional to sin2θ.", "Therefore, when the polarization direction of the operation light is orthogonal to the wavefront of the cavity mode, scattered light is less likely to be generated in the direction orthogonal to the wave front of the cavity mode.", "As described above, the provision of the anti-reflective coating in the irradiated part allows the scattered light generated in the solid medium to exit the solid medium without being reflected at the interface between the solid medium and the outside.", "When the polarization direction of the operation light is set to coincide with the direction orthogonal to the wavefront of the cavity mode, the direction in which the intensity of the scattered light exiting the solid medium increases is mostly limited to an in-plane direction of the wavefront of the cavity mode including an operation light irradiated spot of the solid medium.", "Thus, the anti-reflective coating is applied to the irradiated part, and the polarization direction of the operation light is set to coincide with the direction orthogonal to the wavefront of the cavity mode.", "Therefore, even if the lost photon is lost from an element other than the input/output element for the light in the cavity mode and the light outside of the cavity, for example, even if the lost photon is lost from the cavity mode or due to spontaneous emission from the physical systems used as the qubits, the present embodiment enables the arrangement of the photodetector to be selected to allow the lost photon to be more accurately detected while avoiding the adverse effect of the scattered light generated as a result of scattering of the operation light by the solid medium.", "As described above, the present embodiment adopts at least one of (1) forming the irradiated part of the solid medium to be thinner than the other neighbor parts, (2) the provision of the anti-reflective coating and the optical trap or the light absorber, and (3) the setting of the polarization direction of the operation light to coincide with the direction intersecting the wavefront of the cavity mode.", "The present embodiment thus allows the lost photon to be correctly detected while avoiding the adverse effect of scattering of the operation light allowing the qubits to be manipulated.", "EXAMPLE 3 A quantum computer according to Example 3 uses, as a qubit, quantum states of nuclear spin of Pr3+ ions in the Y2SiO5 crystal.", "A solid medium 151 including qubits as depicted in FIGS.", "15A and 15B is prepared as follows.", "A cube is produced which is 3 mm on a side and which is formed of a Pr3+:Y2SiO5 crystal with 10−6% of Y3+ ions in the Y2SiO5 crystal substituted with Pr3+ ions.", "One face of the cube is processed into a spherical surface which is tangent to the center of the face and which has a radius of curvature of 3.3 mm.", "At this time, the direction of the crystal axis of the Pr3+:Y2SiO5 is set as follows.", "A B axis of the crystal is set to coincide with a direction which is orthogonal to a line connecting the center (designated as an O point) of the spherical surface and the center (designated as a B point) of a plane opposite to the spherical surface and which is orthogonal to one of four planes connected to the spherical surface.", "A D2 axis is set not to fee parallel to the line connecting the O point and the B point together and not to be orthogonal to the line connecting the O point and the B point together.", "As depicted in FIG.", "16, when dielectric multilayer mirrors 162 and 163 are formed on the spherical surface of the solid medium 151, a cavity mode is generated in the solid medium 151.An intersection point between a line connecting the O point and the B point together and the spherical surface formed on the crystal is designated as an A point.", "To introduce interactions between the physical systems (Pr3+ ions) used as qubits, a cavity mode near 494.7 THz is utilized that is included in TEM00 modes generated along a line AB connecting the A point and the B point together, and which resonates with a 3H4-1D2 transition of Pr+ ions.", "This cavity mode has a mode waist at the B point, and a mode waist radius (mode radius) is approximately 10 μm.", "Near the mode waist, the wavefront of the mode is substantially planar.", "At the A point, the mode radius has a maximum value of 33 μm.", "The magnitude (coupling constant) of the interaction between the cavity mode and the Pr3+ ions increases with decreasing distance to the line AB and with decreasing mode: radius.", "Therefore, ions near the B point are used as qubits.", "In the present example, an end surface of the solid medium 151 and the dielectric multilayer mirror 163 are located at the position of the mode waist.", "To avoid scattering of the operation light by the end surface of the solid medium 151 or the dielectric multilayer mirror 163, ions at a C point that is approximately 500 μm closer to the A point than the B point are used as qubits.", "In the present example, a mode waist radius of 10 μm is sufficiently larger than the wavelength of the cavity mode (approximately 606 nm, which corresponds to 494.7 THz).", "Thus, the mode has a small spread angle toward the A point, and thus, even at the C point, a coupling constant substantially similar to the coupling constant at the B point is acquired.", "Therefore, the operation light utilized to manipulate the qubits is radiated to the C point in a focusing manner such that the diameter of the operation light is approximately 10 μm.", "This allows the ions present at the C point to be used as qubits.", "A surface of the solid medium 151 opposite to the spherical surface is also processed into a spherical surface to allow a mode waist to be created inside the solid medium 151.For example, the length (cavity length) between the A point and the B point in the solid medium 151 in the present example is set to 6 mm, a plane at the B point is also processed into a spherical surface that is tangent to the plane at a central point of the plane, and both spherical surfaces are set to have a radius of curvature of 3.3 mm.", "Then, a mode waist is generated at a middle point of a segment connecting the A point and the B point together.", "In that case, the middle point is irradiated with the operation light, and ions present at the middle point are used as qubits.", "When the solid medium 151 is a single crystal that is substantially transparent to the operation light and surfaces at which mirrors are to be provided is sufficiently accurately polished, a main process, in which a photon needed for the interaction between the Pr3+ ions used as qubits is lost from the solid medium 151 in the present example, is considered to be a process in which a photon exit the solid medium 151 through the mirror 162 or 163.To allow detection of a lost photon that are lost during the process, a pinhole 171 with a radius of 100 μm and a photodetector 173 are arranged near the A point, and a pinhole 172 with a radius of 30 μm and a photodetector 174 are arranged near the B point, as depicted in FIG.", "17.In this state, first, operation light of approximately 100 μW is radiated which has an electric field vector orthogonal to the line AB and parallel to the incident surface.", "The total of light intensities detected by the two photodetectors 173 and 174 is recorded as I1.Then, a cavity is prepared by processing a quadratic prism so as to cut away opposite sides of a 100 μm×3 mm rectangle (long sides of the rectangle are parallel to the above-described incident surface) which shares the center of a square surface opposite to the spherical surface of the solid medium 151, with the rectangle left to serve as a mirror.", "As depicted FIG.", "19, the pinhole 171 with a radius of 100 μm and the photodetector 173 are arranged near the A point, and the pinhole 172 with a radius of 30 μm and the photodetector 174 are arranged near the B point.", "As is the case with the above-described structure, the C point is irradiated with operation light, and the total of light intensities detected by the two photodetectors 173 and 174 is recorded as I2.The ratio between I1 and I2 is expressed as follows mainly due to a difference in optical path length of the operation light traveling through the solid medium 151 while generating scattered light.", "I 2 I 1 =  ∫ 0 0.05  { S × 2.5 x 2 + 2.5 2 + 9  S 100 × 0.5 x 2 + 0.5 2 }  dx /  ∫ 0 1.5  { S × 2.5 x 2 + 2.5 2 + 9  S 100 × 0.5 x 2 + 0.5 2 }  dx ≈  3.6 × 10 - 2 In the expression, S denotes the opening area of the pinhole 151 near the A point is denoted as.", "The use of the cavity depicted in FIG.", "18 reduces photons of the scattered light reaching the photodetectors 173 and 174 to approximately one-thirtieth.", "That is, the quantum computer according to the present example (FIG.", "19) includes the solid medium 151, which is thinner at the irradiated part than at the other parts near the irradiated part, thus enabling a reduction in the adverse effect of the scattered light resulting from scattering of the operation light by the solid medium and preventing accurate detection of a lost photon.", "EXAMPLE 4 A quantum computer according to Example 4 is similar to the quantum computer in Example 3 except that an anti-reflective coating is applied to an operation light incident surface and an operation light emitting surface of the solid medium 151.The coating reduces the probability that the operation light is reflected by the emitting surface and enters the solid medium 151 again to generate scattered light or repeatedly reflected between the incident surface and the emitting surface to generate scattered light in the solid medium or that scattered light generated in the solid medium 151 reaches the emitting surface or the incident surface and is then reflected by the surface to return into the solid medium 151.Thus, compared to Example 3, the present example enables a further reduction in photons of the scattered light reaching the photodetectors.", "In the present example, an optical trap is provided which receives the operation light exiting through the emitting surface.", "The optical trap reduces the adverse effect of the operation light exiting through the emitting surface and impinging on an object or being scattered by air or particulates in the air before reaching the photodetectors, thus preventing accurate detection of a lost photon.", "The provision of the optical trap is also effective in Example 3 and in Example 5 described below.", "As described above, in the quantum computer according to the present example, the anti-reflective coating is applied to the operation light incident surface and operation light emitting surface of the solid material, and the optical trap or a light absorber is provided beyond the emitting surface.", "This enables a reduction in the adverse effect of scattered light resulting from scattering of the operation light by the solid medium or a substance outside the solid medium and preventing accurate detection of a lost photon.", "EXAMPLE 5 In Example 5, in a quantum computer similar to the quantum computer in Example 4, the polarization direction of the operation light is set to coincide with the direction of the line AB, that is, to be orthogonal to the wavefront of the cavity mode.", "In this case, the angle between the traveling direction of scattered light reaching the photodetectors and the polarization direction of the operation light is denoted as θ1 for the photodetector 173 at the A point, and as θ2 for the photodetector 174 at the B point.", "Then, the following are given.", "sin 2  θ 1 < ( 0.1 + 0.05 ) 2 2.5 2 + ( 0.1 + 0.05 ) 2 ≅ 3.6 × 10 - 3 sin 2  θ 2 < ( 0.05 + 0.03 ) 2 0.5 2 + ( 0.05 + 0.03 ) 2 ≅ 2.4 × 10 - 2 In the polarization of the operation light in Example 3 and Example 4, the following hold true.", "SIN2θ1≈1 sin2θ2≈1 When the angle between the polarization direction of the operation light and a direction from a scatterer toward an observation point where the intensity of the scattered light resulting from scattering of the operation light is observed is denoted as θ, the intensity of the scattered light is proportional to sin2θ.", "Therefore, the present example sets the polarization direction of the operation light as described above to allow photons of the scattered light reaching the photodetectors to be further reduced to approximately 1/100 to 1/1000 relative to Example 3.Scattering caused by the operation light inside the solid medium 151 in the present example is considered to be comparable to scattering of light with a wavelength of 700 nm by quarts in optical fibers.", "The quarts in the optical fibers causes a scattering loss of approximately 3 dB/km.", "Therefore, the following expression expresses a total scattered light intensity (scattering loss) resulting from traveling of incident light with an intensity Iin through a 1-km solid medium 151: I i   n × ( 1 - 10 - 3 10  l ) .", "In the present example, in the irradiated part, the solid medium 151 has a thickness of 100 μm in the traveling direction of the operation light.", "Thus, the total scattered light resulting from scattering of 100 μW operation light is expressed as follows: 100 × 10 - 6 × ( 1 - 10 - 3 10 × 10 - 2 ) ≅ 6.91 × 10 - 12   ( W ) .", "In this case, if the polarization direction of the operation light is orthogonal to the line AB, the intensity I of scattered light reaching the two photodetectors 173, 174 is expressed as follows.", "I < 6.91 × 10 - 12 × ( 0.1 × 2 2.5 × 2 × π + 0.03 × 2 0.5 × 2 × π ) ≅ 2 × 10 - 13   ( W ) Thus, when the polarization direction of the operation light is parallel to the line AB, the intensity of the scattered light reaching the two photodetectors 173 and 174 can be made lower than 10−15 W, which is 1/100 to 1/1000 of the intensity I in the expression.", "For example, when a two-quantum-bit gate is executed at 100 μs, since a lost photon has an energy of approximately 4×10−19 J, it is necessary to accurately detect light of 4×10−19 J/100 μs=4×10−15 W, which corresponds to a lost photon intensity in the case of a loss of one photon for one gate, in order to achieve detection of a lost photon for this quantum gate.", "The present example allows the intensity of scattered light resulting from scattering of the operation light and reaching the photodetector to be reduced to 10−15 W or less, enabling a lost photon to be accurately detected.", "Example 3, Example 4, and Example 5 assume that multiple scattering is negligibly small in magnitude in which intense operation light causes generation of scattered light that is further scattered in the solid medium.", "However, even with multiple scattering taken into account, the technique described in the second embodiment is effective.", "Furthermore, in Example 3, Example 4, and Example 5, even when scattering at the interface between the solid medium and the outside is taken into account, the technique, described in the second embodiment is effective.", "Preferred aspects of the second embodiment will be described below.", "[1] A quantum computer according to a first aspect includes: a cavity including a solid medium including physical systems used as qubits, the cavity having a cavity mode which resonates with the physical systems; a light source unit which irradiates the physical systems with operation light having a polarization direction crossing a wavefront of the cavity mode when the physical systems are coupled to each other by the cavity mode; and a detector which detects a photon lost from the physical systems or from the cavity mode.", "[2]: In the quantum computer set forth in [1], the solid medium includes a first part where the physical systems are arranged and a second part different from the first part, the first part being smaller than the second part in a thickness in a traveling direction of the operation light.", "[3]: The quantum computer set forth in [1] or [2] further includes a first anti-reflective coating applied to a first surface of the solid medium on which the operation light is incident, a second anti-reflective coating applied to a second surface of the solid medium through which the operation light exits, and an optical trap or a light absorber arranged opposite to the second anti-reflective coating.", "[4]: A quantum computer according to a second aspect includes: a cavity including a solid medium including a first part where physical systems used as qubits are arranged and a second part different from the first part, the cavity having a cavity mode which resonates with the physical systems, the first part being smaller than the second part in a thickness in a traveling direction of operation light to manipulate the physical systems; a light source unit which irradiates the physical systems with the operation light when the physical systems are coupled to each other by the cavity mode; and a detector which detects a photon lost from the physical systems or from the cavity mode.", "[5]: The quantum computer set forth in [4] further includes a first anti-reflective coating applied to a first surface of the solid medium on which the operation light is incident, a second anti-reflective coating applied to a second surface of the solid medium through which the operation light exits, and an optical trap or a light absorber arranged opposite to the second anti-reflective coating.", "[6]: A quantum computer according to a third aspect includes: a cavity including a solid medium including physical systems used as qubits, the cavity having a cavity mode which resonates with the physical systems, the cavity further including a first anti-reflective coating applied to a first surface of the solid medium on which operation light to manipulate the physical systems is incident, a second anti-reflective coating applied to a second surface of the solid medium through which the operation light exits; an optical trap or a light absorber: arranged opposite to the second anti-reflective coating; a light source unit which irradiates the physical systems with the operation light when the physical systems are coupled to each other by the cavity mode; and a detector which detects a photon lost from the physical systems or from the cavity mode.", "[7]: A quantum calculation method according to a fourth aspect includes: providing a cavity including a solid medium including physical systems used as qubits, the cavity having a cavity mode which resonates with the physical systems; irradiating the physical systems with operation light having a polarization direction crossing a wavefront of the cavity mode when the physical systems are coupled to each other by the cavity mode; and detecting a photon lost from the physical systems or from the cavity mode.", "[8]: In the quantum calculation method set forth in [7], the solid medium includes a first part where the physical systems are arranged and a second part different from the first part, the first part being smaller than the second part in a thickness in a traveling direction of the operation light.", "[9]: The quantum calculation method set forth in [7] or [8] further includes providing a first anti-reflective coating applied to a first surface of the solid medium on which the operation light is incident, a second anti-reflective coating applied to a second surface of the solid medium through which the operation light exits, and an optical trap or a light absorber arranged opposite to the second anti-reflective coating.", "[10] A quantum calculation method according to a fifth aspect includes: providing a cavity including a solid medium including a first part where physical systems used as qubits are arranged and a second part different from the first part, the cavity having a cavity mode which resonates with the physical systems, the first part being smaller than the second part in a thickness in a traveling direction of operation light to manipulate the physical systems; irradiating the physical systems with the operation light while the physical systems are coupled to each other by the cavity mode; and detecting a photon lost from the physical systems or from the cavity mode.", "[11]: The quantum calculation method set forth in [10], further includes providing a first anti-reflective coating applied to a first surface of the solid medium on which the operation light is incident, a second anti-reflective coating applied to a second surface of the solid medium through which the operation light exits, and an optical trap or a light absorber arranged opposite to the second anti-reflective coating.", "[12]: A quantum calculation method according to a sixth aspect includes: providing a cavity including a solid medium including physical systems used as qubits, the cavity having a cavity mode which resonates with the physical systems, a first anti-reflective coating; being applied to a first surface of the solid medium on which operation light to manipulate the physical systems is incident, a second anti-reflective coating applied to a second surface of the solid medium through which the operation light exits; providing an optical trap or a light absorber arranged opposite to the second anti-reflective coating; irradiating the physical systems with the operation light when the physical systems are coupled to each other by the cavity mode; and detecting a photon lost from the physical systems or from the cavity mode.", "While certain embodiments have been described, these embodiments have been presented by way of example only, and are not intended to limit the scope of the inventions.", "Indeed, the novel embodiments described herein may be embodied in a variety of other forms; furthermore, various omissions, substitutions and changes in the form of the embodiments described herein may be made without departing from the spirit of the inventions.", "The accompanying claims and their equivalents are intended to cover such forms or modifications as would fail within the scope and spirit of the inventions." ] ]
Patent_15872638
[ [ "EXPANSIVE CEMENT", "An expansive additive composition for use in Portland cements and a method of using such an additive composition is provided.", "The additive composition can include a calcium aluminate cement additive and a lithium compound.", "The additive composition is capable of producing expansion in set cements when the temperature is at or below room temperature and minimizes the amount of calcium aluminate cement additive needed." ], [ "1.An expansion additive composition for use in Portland cements comprising: a calcium aluminate cement in an amount from about 5% to about 50% by weight of the composition; a lithium compound in an amount from about 0.01% to about 5.00% by weight of the composition; calcium hydroxide present in an amount from about 1% to about 20% by weight of the composition; and sodium bicarbonate present in an amount from about 0.1% to about 5.0% by weight of the composition.", "2.The composition of claim 1, further comprising calcium sulfate present in an amount from about 50% to about 80% by weight of the composition.", "3.The composition of claim 1, wherein said calcium aluminate cement is in an amount from about 10% to about 40% by weight of the composition and wherein said lithium compound is in an amount from about 0.05% to about 1.00% by weight of the composition.", "4.The composition of claim 3, wherein said calcium aluminate cement is in an amount from 15% to 35% by weight of the composition and wherein said lithium compound is in an amount from 0.10% to 0.50% by weight of the composition.", "5.The composition of claim 1, wherein said lithium compound is a lithium salt selected from the group consisting of lithium carbonate, lithium halides, lithium sulfate, hydrates of lithium sulfate, lithium nitrate, lithium hydroxide, and mixtures thereof.", "6.The composition of claim 1, further comprising calcium sulfate, and wherein: said calcium aluminate cement is in an amount from 15% to 35% by weight of the composition; said lithium compound is a lithium salt selected from the group consisting of lithium carbonate, lithium halides, lithium sulfate, hydrates of lithium sulfate, lithium nitrate, lithium hydroxide, and mixtures thereof, and said lithium salt is in an amount from 0.10% to 0.50% by weight of the composition; said calcium sulfate is present in an amount from about 50% to about 80% by weight of the composition.", "7.A method of using an expansion additive composition, the method comprising: mixing an additive composition, a Portland cement and water so as to form a slurry, wherein the additive composition comprises: a calcium aluminate cement in an amount from about 0.5% to about 8.0% by weight of said Portland cement; a lithium compound in an amount from about 0.001% to about 0.50% by weight of said Portland cement; calcium sulfate present in an amount from about 1% to about 15% by weight of said Portland cement; calcium hydroxide present in an amount from about 0.1% to about 3.0% by weight of said Portland cement; and sodium bicarbonate present in an amount from about 0.01% to about 1.00% by weight of said Portland cement; and introducing the slurry into a subterranean formation.", "8.The method of claim 7, wherein said subterranean formation is at a temperature below about 100° F. 9.The method of claim 8, wherein said composition results in a 10% increase in volume of the slurry when setting occurs at a temperature of below 100° F. (37.8° C.).", "10.The method of claim 9, wherein said subterranean formation is at a temperature below about 73° F. (23° C.).", "11.The method of claim 7, wherein a bore of a well extends through said subterranean formation and the method further comprises allowing the slurry to form a plug in the bore.", "12.The composition of claim 7, wherein the lithium compound is a lithium salt selected from the group consisting of lithium carbonate, lithium halides, lithium sulfate, hydrates of lithium sulfate, lithium nitrate, lithium hydroxide, and mixtures thereof.", "13.The method of claim 12, wherein said calcium aluminate cement is in an amount from about 1.0% to about 5.0% by weight of said Portland Cement, and wherein said lithium compound is in an amount from about 0.005% to about 0.150% by weight of said Portland cement.", "14.The method of claim 13, wherein said calcium aluminate cement is in an amount from 1.5% to 3.5% by weight of said Portland cement and said lithium compound is in an amount from 0.010% to 0.100% by weight of said Portland cement.", "15.The method of claim 14, wherein said composition results in at least a 17% increase in volume of the slurry when setting occurs at a temperature of below 60° F. (15.6° C.).", "16.The method of claim 15, wherein a bore of a well extends through said subterranean formation with said bore defined by a borehole wall, wherein a casing is in said bore, and wherein the method further comprises: placing the slurry between the casing and the borehole wall.", "17.The method of claim 16, further comprising allowing the slurry to form a plug in the bore.", "18.The method of claim 7, wherein said additive composition, said Portland cement and water are mixed using mixing equipment.", "19.The method of claim 7, wherein the slurry is introduced into the subterranean formation using one or more pumps.", "20.A method of using an expansion additive composition, the method comprising: mixing an additive composition, a Portland cement and water so as to form a slurry, wherein the additive composition comprises: a calcium aluminate cement in an amount from about 1.0% to about 5.0% by weight of said Portland cement; a lithium salt in an amount from about 0.005% to about 0.150% by weight of said Portland cement, wherein the lithium salt is selected from the group consisting of lithium carbonate, lithium halides, lithium sulfate, hydrates of lithium sulfate, lithium nitrate, lithium hydroxide, and mixtures thereof; calcium sulfate present in an amount from about 1% to about 15% by weight of said Portland cement; calcium hydroxide present in an amount from about 0.1% to about 3.0% by weight of said Portland cement; and sodium bicarbonate present in an amount from about 0.01% to about 1.00% by weight of said Portland cement; and introducing the slurry into an annulus between a casing and a borehole wall, wherein said borehole wall and said casing are at a temperature below about 100° F., and wherein said composition results in a 10% increase in volume of the slurry when setting occurs at a temperature of below 100° F. (37.8° C.)." ], [ "<SOH> BACKGROUND <EOH>Cement systems, such as Portland cement, typically are subject to shrinkage during and after setting and hardening.", "In some applications such shrinkage is problematic.", "For example, in downhole applications for cementing a casing in a well and for abandonment plugs in wells, it is crucial that good bonding occurs between the set cement and the casing and/or between the set cement and the formation borehole wall in order to achieve effective zonal isolation.", "Poor cement/formation bonding, poor cement/casing bonding, expansion and contraction of the casing resulting from internal pressure or thermal stress, and inadequate mud removal all contribute to the formation of small gaps or “microannuli” at the cement/casing or cement/formation interface.", "These microannuli allow communication between the zones through which the wellbore extends.", "Cement systems that expand slightly after setting are a proven means of preventing and/or sealing microannuli and improving primary cementing results.", "The improved bonding is the result of mechanical resistance or tightening of the cement against the casing and formation.", "In unrestrained environments, such as cement use in buildings and roads, expansion of the cement during setting and hardening can result in cracking and failure.", "In the restrained downhole environment, the cement expands to eliminate void spaces and reduce internal cement porosity.", "Current additive compositions that are introduced into Portland cements to provide expansive cement typically rely on elevated temperatures to achieve a sufficient expansion effect, often above 100° F. (37.8° C.).", "There is a need, however, for expansive Portland cement systems that achieve sufficient expansion at temperatures below 100° F. (37.8° C.) and more typically at temperatures below room temperature (about 73° F. or about 23° C.)." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>FIG.", "1 illustrates a system for preparation and delivery of a cement composition to a wellbore in accordance with aspects of the present disclosure.", "FIG.", "2A illustrates surface equipment that may be used in placement of a cement composition in a wellbore in accordance with aspects of the present disclosure.", "FIG.", "2B illustrates placement of a cement composition into a wellbore annulus in accordance with aspects of the present disclosure.", "FIG.", "3 is a graph of expansion versus days for each cement composition sample in the Examples.", "FIG.", "4 is a chart of the expansion rate for each cement composition sample in the Examples.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a divisional of U.S. patent application Ser.", "No.", "15/319,309 filed Dec. 15, 2016, now allowed, which is a national phase of PCT Patent Application No.", "PCT/US2014/058270 filed Sep. 30, 2014, and which is incorporated by reference.", "FIELD This disclosure relates to cement compositions and more particularly to expansive cement compositions, which expand slightly after setting.", "Such compositions are useful for cementing a casing in place in a bore of an oil, gas or other well and in well abandonment operations.", "BACKGROUND Cement systems, such as Portland cement, typically are subject to shrinkage during and after setting and hardening.", "In some applications such shrinkage is problematic.", "For example, in downhole applications for cementing a casing in a well and for abandonment plugs in wells, it is crucial that good bonding occurs between the set cement and the casing and/or between the set cement and the formation borehole wall in order to achieve effective zonal isolation.", "Poor cement/formation bonding, poor cement/casing bonding, expansion and contraction of the casing resulting from internal pressure or thermal stress, and inadequate mud removal all contribute to the formation of small gaps or “microannuli” at the cement/casing or cement/formation interface.", "These microannuli allow communication between the zones through which the wellbore extends.", "Cement systems that expand slightly after setting are a proven means of preventing and/or sealing microannuli and improving primary cementing results.", "The improved bonding is the result of mechanical resistance or tightening of the cement against the casing and formation.", "In unrestrained environments, such as cement use in buildings and roads, expansion of the cement during setting and hardening can result in cracking and failure.", "In the restrained downhole environment, the cement expands to eliminate void spaces and reduce internal cement porosity.", "Current additive compositions that are introduced into Portland cements to provide expansive cement typically rely on elevated temperatures to achieve a sufficient expansion effect, often above 100° F. (37.8° C.).", "There is a need, however, for expansive Portland cement systems that achieve sufficient expansion at temperatures below 100° F. (37.8° C.) and more typically at temperatures below room temperature (about 73° F. or about 23° C.).", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates a system for preparation and delivery of a cement composition to a wellbore in accordance with aspects of the present disclosure.", "FIG.", "2A illustrates surface equipment that may be used in placement of a cement composition in a wellbore in accordance with aspects of the present disclosure.", "FIG.", "2B illustrates placement of a cement composition into a wellbore annulus in accordance with aspects of the present disclosure.", "FIG.", "3 is a graph of expansion versus days for each cement composition sample in the Examples.", "FIG.", "4 is a chart of the expansion rate for each cement composition sample in the Examples.", "DETAILED DESCRIPTION It has now been discovered that relatively small amounts of a lithium compound added to a Portland cement along with some calcium aluminate cement and calcium sulfate provide for cements having suitable expansion even at relatively low temperatures, generally below about 100° F. (37.8° C.) and more typically below about room temperature (73° F. or 23° C.) and even at temperatures below 60° F. (15.6° C.) or temperatures of about 55° F. (12.8° C.) or below.", "A typical expansive cement system or composition according to an embodiment comprises a Portland cement and an expansion additive.", "While most Portland cements can be used, typically the Portland cement is selected from the group consisting of API Class A Portland cement, API Class C Portland cement, API Class G Portland cement, API Class H Portland cement and any combination thereof.", "Additionally, the cement system can include fluid loss additives, set accelerators, cure rate adjusters, and similar.", "The expansion additive composition comprises calcium aluminate cement, a lithium compound and calcium sulfate (typically added as ground gypsum).", "The calcium sulfate can be added to the cement system separately from the other components of the expansion additive composition.", "The expansion additive composition can also comprise calcium hydroxide and sodium bicarbonate.", "An exemplary expansion additive composition comprises calcium aluminate present from about 5% to about 50%; a lithium compound present from about 0.01% to about 5.00%, calcium sulfate present in an amount from about 50% to about 80% by weight of the composition; calcium hydroxide present in an amount from about 1% to about 20% by weight of the composition; and sodium bicarbonate present in an amount from about 0.1% to about 5% by weight of the composition, all based on weight of the expansion additive composition.", "Generally, the calcium aluminate cement can be present in an amount of at least about 5%, at least about 10% or at least 15% up to about 50%, about 40% or 35% by weight of the additive composition.", "The lithium compound can be present in an amount of at least about 0.01%, at least about 0.05% or at least 0.10% up to about 5.00%, about 1.00%, 0.50% or 0.30% by weight of the additive composition.", "The calcium sulfate can be present in an amount of at least about 40%, at least about 50%, or at least 60% up to about 90%, about 80% or 75% by weight of the additive composition.", "The calcium hydroxide can be present in an amount from at least about 1%, at least about 5% or at least 7% up to about 20%, about 15% or 12% by weight of the additive composition.", "The sodium bicarbonate can be present in an amount from at least about 0.1%, at least about 0.5% or at least 1.0% up to about 5%, about 3% or 2% by weight of the additive composition.", "While not wishing to be bound by theory, the volume expansion of the resulting ettringite product from the calcium aluminate and calcium sulfate provides expansion action, and it is believed that the lithium compound co-additive enhances the performance of the expansion additive composition through interaction with the calcium aluminate cement.", "The addition of a lithium compound to the other components of the expansion additive composition improves the reactivity of the system such that the rate of expansion is more rapid and the desirable action of the expansive cement composition can be utilized effectively at lower temperatures than that of conventional expansion additives.", "The lithium compound can result in an expansion of at least 10% in the set cement within 1 day, of at least 15% in the set cement within 3 days and at least 17% within 7 days.", "Exemplary lithium compounds are lithium salts.", "Most lithium salts can be used in the expansion additive composition.", "Suitable lithium salts include lithium carbonate, lithium halides, lithium sulfate, hydrates of lithium sulfate, lithium nitrate, and lithium hydroxide.", "The above described expansion additive composition can be mixed with Portland cement to produce an expansive cement composition.", "Typically, the expansion additive composition will be added in an amount from about 1% to about 20% based on the weight of the Portland cement.", "More typically, the expansion additive composition will be added in an amount from 5% to 15% based on the weight of the Portland cement.", "Prior to use downhole, water is added to the resulting mixture to create a slurry.", "The water will typically be added in an amount from about 30% to about 60%, and more typically, from 40% to 55% by weight of the Portland cement.", "Generally, the resulting expansive cement composition can comprise from about 0.5% to about 8.0% calcium aluminate cement by weight of the Portland cement.", "However, the expansive cement composition can comprise at least about 1.0%, or at least 1.5% up to about 5.0% or 3.5% calcium aluminate cement by weight of the Portland cement.", "The expansive cement composition can comprise from about 0.001% to about 0.500% lithium compound by weight of the Portland cement.", "However, the expansive cement composition can comprise at least about 0.005%, or at least 0.010% up to about 0.150, about 0.100% or 0.050% lithium compound by weight of the Portland cement.", "The expansive cement composition can comprise from about 1% to about 15% calcium sulfate by weight of the Portland cement.", "However, the expansive cement composition can comprise at least about 5% up to about 10% calcium sulfate by weight of the Portland cement.", "Further, the calcium hydroxide can be present in an amount from about 0.1% to about 3.0% or from 0.5% to 2.0% by weight of the Portland cement and the sodium bicarbonate can be present in amount from about 0.01% to about 1.00% or from 0.05% to 0.5% by weight of the Portland cement.", "In some embodiments, the expansive cement composition comprises a set accelerator, such as calcium chloride.", "If calcium chloride is used, it can be present in an amount of at least about 0.1% or about 0.5% up to about 5.0% or up to 2% by weight of the Portland cement.", "Additionally, the set accelerator can be mixed with the expansion additive composition prior to the additive composition being introduced to the Portland cement.", "The expansive cement composition can be used in a method wherein the Portland cement, expansion additive composition and water are mixed to form a slurry.", "The resulting cement slurry composition is then introduced into the bore to form a plug or to cement casing in the borehole.", "In cementing casing in the borehole, the cement slurry composition is placed between the casing and the borehole wall.", "The borehole can be below about 100° F. (37.8° C.), below 73° F. (23° C.), below 60° F. (15.6° C.) or at about 55° F. (12.8° C.) or below at the site to be cemented.", "The exemplary compositions disclosed herein may directly or indirectly affect one or more components or pieces of equipment associated with the preparation, delivery, recapture, recycling, reuse, and/or disposal of the disclosed compositions.", "For example, the disclosed compositions may directly or indirectly affect one or more mixers, related mixing equipment, mud pits, storage facilities or units, composition separators, heat exchangers, sensors, gauges, pumps, compressors, and the like used to generate, store, monitor, regulate, and/or recondition the exemplary compositions.", "The disclosed compositions may also directly or indirectly affect any transport or delivery equipment used to convey the compositions to a well site or downhole such as, for example, any transport vessels, conduits, pipelines, trucks, tubulars, and/or pipes used to compositionally move the exemplary compositions from one location to another, any pumps, compressors, or motors (e.g., topside or downhole) used to drive the exemplary compositions into motion, any valves or related joints used to regulate the pressure or flow rate of the exemplary compositions, and any sensors (i.e., pressure and temperature), gauges, and/or combinations thereof, and the like.", "The disclosed compositions may also directly or indirectly affect the various downhole equipment and tools that may come into contact with the cement compositions/additives such as, but not limited to, wellbore casing, wellbore liner, completion string, insert strings, drill string, coiled tubing, slickline, wireline, drill pipe, drill collars, mud motors, downhole motors and/or pumps, cement pumps, surface-mounted motors and/or pumps, centralizers, turbolizers, scratchers, floats (e.g., shoes, collars, valves, etc.", "), logging tools and related telemetry equipment, actuators (e.g., electromechanical devices, hydromechanical devices, etc.", "), sliding sleeves, production sleeves, plugs, screens, filters, flow control devices (e.g., inflow control devices, autonomous inflow control devices, outflow control devices, etc.", "), couplings (e.g., electro-hydraulic wet connect, dry connect, inductive coupler, etc.", "), control lines (e.g., electrical, fiber optic, hydraulic, etc.", "), surveillance lines, drill bits and reamers, sensors or distributed sensors, downhole heat exchangers, valves and corresponding actuation devices, tool seals, packers, cement plugs, bridge plugs, and other wellbore isolation devices, or components, and the like.", "Referring now to FIG.", "1, a system that may be used in the preparation of a cement composition in accordance with example embodiments will now be described.", "FIG.", "1 illustrates a system 2 for preparation of a cement composition and delivery to a wellbore in accordance with certain embodiments.", "As shown, the cement composition may be mixed in mixing equipment 4, such as a jet mixer, re-circulating mixer, or a batch mixer, for example, and then pumped via pumping equipment 6 to the wellbore.", "In some embodiments, the mixing equipment 4 and the pumping equipment 6 may be disposed on one or more cement trucks as will be apparent to those of ordinary skill in the art.", "In some embodiments, a jet mixer may be used, for example, to continuously mix the composition, including water, as it is being pumped to the wellbore.", "An example technique and system for placing a cement composition into a subterranean formation will now be described with reference to FIGS.", "2A and 2B.", "FIG.", "2A illustrates surface equipment 10 that may be used in placement of a cement composition in accordance with certain embodiments.", "It should be noted that while FIG.", "2A generally depicts a land-based operation, those skilled in the art will readily recognize that the principles described herein are equally applicable to subsea operations that employ floating or sea-based platforms and rigs, without departing from the scope of the disclosure.", "As illustrated by FIG.", "2A, the surface equipment 10 may include a cementing unit 12, which may include one or more cement trucks.", "The cementing unit 12 may include mixing equipment 4 and pumping equipment 6 (e.g., FIG.", "1) as will be apparent to those of ordinary skill in the art.", "The cementing unit 12 may pump a cement composition 14 through a feed pipe 16 and to a cementing head 18 which conveys the cement composition 14 downhole.", "Turning now to FIG.", "2B, the cement composition 14 may be placed into a subterranean formation 20 in accordance with example embodiments.", "As illustrated, a wellbore 22 may be drilled into the subterranean formation 20.While wellbore 22 is shown extending generally vertically into the subterranean formation 20, the principles described herein are also applicable to wellbores that extend at an angle through the subterranean formation 20, such as horizontal and slanted wellbores.", "As illustrated, the wellbore 22 comprises walls 24.In the illustrated embodiments, a surface casing 26 has been inserted into the wellbore 22.The surface casing 26 may be cemented to the walls 24 of the wellbore 22 by cement sheath 28.In the illustrated embodiment, one or more additional conduits (e.g., intermediate casing, production casing, liners, etc.)", "shown here as casing 30 may also be disposed in the wellbore 22.As illustrated, there is a wellbore annulus 32 formed between the casing 30 and the walls 24 of the wellbore 22 and/or the surface casing 26.One or more centralizers 34 may be attached to the casing 30, for example, to centralize the casing 30 in the wellbore 22 prior to and during the cementing operation.", "With continued reference to FIG.", "2B, the cement composition 14 may be pumped down the interior of the casing 30.The cement composition 14 may be allowed to flow down the interior of the casing 30 through the casing shoe 42 at the bottom of the casing 30 and up around the casing 30 into the wellbore annulus 32.The cement composition 14 may be allowed to set in the wellbore annulus 32, for example, to form a cement sheath that supports and positions the casing 30 in the wellbore 22.While not illustrated, other techniques may also be utilized for introduction of the cement composition 14.By way of example, reverse circulation techniques may be used that include introducing the cement composition 14 into the subterranean formation 20 by way of the wellbore annulus 32 instead of through the casing 30.As it is introduced, the cement composition 14 may displace other fluids 36, such as drilling fluids and/or spacer fluids that may be present in the interior of the casing 30 and/or the wellbore annulus 32.At least a portion of the displaced fluids 36 may exit the wellbore annulus 32 via a flow line 38 and be deposited, for example, in one or more retention pits 40 (e.g., a mud pit), as shown on FIG.", "2A.", "Referring again to FIG.", "2B, a bottom plug 44 may be introduced into the wellbore 22 ahead of the cement composition 14, for example, to separate the cement composition 14 from the fluids 36 that may be inside the casing 30 prior to cementing.", "After the bottom plug 44 reaches the landing collar 46, a diaphragm or other suitable device ruptures to allow the cement composition 14 through the bottom plug 44.In FIG.", "2B, the bottom plug 44 is shown on the landing collar 46.In the illustrated embodiment, a top plug 48 may be introduced into the wellbore 22 behind the cement composition 14.The top plug 48 may separate the cement composition 14 from a displacement fluid 50 and also push the cement composition 14 through the bottom plug 44.Examples The present invention is exemplified by the following examples.", "The examples are not intended and should not be taken to limit, modify or define the scope of the present invention in any manner.", "Six cement additive composition samples were prepared.", "The six samples were designated as Samples A-F and the composition of each is shown in Table 1, wherein the percentages are by weight of the total cement additive composition.", "In the samples, two different formulations of calcium aluminate cement (CAC) were used.", "The CAC's were calcium aluminate cement made by Kerneos Inc. and marketed under the trade name Secar 71 and Secar 51.Secar 51 contains more of the monocalcium aluminate clinker phase.", "TABLE 1 Component Sample A Sample B Sample C Sample D Sample E Sample F Calcium Sulfate 71.4% 62.7% 60.2% 54.0% 71.4% 71.3% Secar 71 CAC 17.4% 26.1% 28.9% 34.8% — 17.4% Secar 51 CAC — — — — 17.4% — Calcium Hydroxide 10.0% 10.0% 9.6% 10.0% 10.0% 10.0% Sodium Bicarbonate 1.2% 1.2% 1.2% 1.2% 1.2% 1.2% Lithium Carbonate 0.2% Total 100.0% 100.0% 100.0% 100.0% 100.0% 100.0% Seven cement slurry samples were then prepared comprising Class H Portland cement.", "The first cement sample designated as Sample I had no expansion additive.", "The other six cement samples each contained one of cement additive Samples A-F and were designated as cement Sample II.A, Sample II.B, Sample II.C, Sample II.D, Sample II.E and Sample II.F, respectively.", "All the samples included calcium chloride as a set accelerator.", "Also, all the samples included a fluid loss additive marketed under the trade name Halad 322 by Halliburton Energy Services, Inc.", "The formulations of the cement samples are shown in Table II, wherein the percentages are by weight of the Portland cement.", "TABLE 2 Component Sample I Sample II.A through II.F Class H Portland Cement 100.0% 100.0% Expansion Additive — 10.0% Fluid Loss Additive 0.6% 0.6% Set Accelerator 1.0% 1.0% Deionized H2O 49.4% 49.4% Sample I was tested to gauge the performance of Portland cement without any expansion additive.", "Expansion additives A-F were mixed into Portland cement sample II at 10% by weight of Portland cement, as indicated in Table 1.Samples I and Samples II.A-II.F were prepared under standard API conditions, then poured into expansion molds to be cured over a 7 day period at 55° F. (12.8° C.) in a recirculating water bath.", "The expansion measurements for each sample were taken daily with a micrometer.", "The results from the expansion tests are displayed in FIG.", "1.All test samples that contained expansion additives showed greater overall expansion than Portland cement alone, except Sample II.E.", "These results indicate that increasing the amount of CAC provides greater overall expansion when cured at 55° F. (12.8° C.).", "Sample II.D contained twice the CAC as Sample II.A, and expanded nearly 130% more over the 7 day period.", "Samples II.B and Sample II.C, which contained one and half times the amount of CAC in Sample II.A, showed only moderate improvements in expansion.", "Each of Samples II.A-II.E did not set in 24 hours, and thus, an expansion reading could not be recorded at the end of day 1.These samples were observed to have set within 48 hours, however, and measurements were taken from that point onward.", "Sample II.F had the same formulation as Sample II.A but lithium carbonate was added as a component to the expansion additive.", "Lithium carbonate was added at 0.2% by weight of expansion additive composition.", "When cured in the water bath at 55° F. (12.8° C.), Sample II.F set suitably and expanded a great deal within 24 hours.", "This represented a significant improvement over the previously tested samples.", "The overall expansion of Sample II.F was nearly 200% greater than expansion for Sample II.A under the test conditions.", "Furthermore, the expansion rate in the early states of curing (i.e.", "within 3 days) and through the entire test period are greater for Sample II.F than any other sample tested.", "FIG.", "2 charts the expansion rate for each test sample through the initial period (day 0-3) and over the entire test period (day 0-7).", "As can be seen, the expansion additive containing the lithium ion compound gives rapid expansion, even at low temperatures, and provides much improved overall expansion.", "The lithium compound additive is capable of producing expansion in set cements when the temperature is at or below room temperature and minimizes the amount of calcium aluminate cement additive needed as illustrated by a comparison of Samples II.D and II.F.", "Sample II.D has the closest performance to that of Sample II.F but utilizes twice the amount of CAC and does not achieve as good a result in setting time and expansion.", "In accordance with the above disclosure, in one embodiment there is provided an expansion additive composition for use in Portland cement.", "The additive, comprises a calcium aluminate cement and lithium compound.", "The calcium aluminate cement is present in an amount from about 5% to about 50% by weight of the composition, and the lithium compound in an amount from about 0.01% to about 5.00% by weight of the composition.", "More preferably, the calcium aluminate cement is in an amount from about 10% to about 40% by weight of the composition, and the lithium compound is in an amount from about 0.05% to about 1.00% by weight of the composition.", "Alternatively, the calcium aluminate cement is in an amount from 15% to 35% by weight of the composition, and the lithium compound is in an amount from 0.10% to 0.50% by weight of the composition.", "The lithium compound can be a lithium salt.", "The lithium salt can be selected from the group consisting of lithium carbonate, lithium halides, lithium sulfate, hydrates of lithium sulfate, lithium nitrate, lithium hydroxide, and mixtures thereof.", "Additionally, the composition can further comprise calcium sulfate present in an amount from about 50% to about 80% by weight of the composition.", "Also, the composition can comprise calcium hydroxide present in an amount from about 1% to about 20% by weight of the composition; and sodium bicarbonate present in an amount from about 0.1% to about 5.0% by weight of the composition.", "In another aspect, the expansion additive composition for use in Portland cement consists essentially of: a calcium aluminate cement in an amount from about 5% to about 50% by weight of the composition; a lithium compound in an amount from 0.01% to 5.00% by weight of the Portland cement; and one or more compounds selected from the group consisting of calcium sulfate, calcium hydroxide, sodium bicarbonate, a set accelerator, and a fluid loss additive.", "In another embodiment, there is provided an expansive cement composition comprising a Portland cement, calcium aluminate cement, lithium compound and calcium sulfate.", "The calcium aluminate cement can be present in an amount from about 0.5% to about 8.0% by weight of the Portland cement.", "The lithium compound can be present in an amount from about 0.001% to about 0.500% by weight of said Portland cement.", "Preferably, the calcium aluminate cement can be present in an amount from about 1.0% to about 5.0% by weight of the Portland cement and the lithium compound can be present in an amount from about 0.005% to about 0.150% by weight of the Portland cement.", "Alternatively, the calcium aluminate cement can be present in an amount from 1.5% to 3.5% by weight of the Portland cement, and the lithium compound can be in an amount from 0.010% to 0.100% by weight of the Portland cement.", "The cement composition can comprise calcium sulfate present in an amount from about 1% to about 15% by weight of the Portland cement.", "The cement composition can have, during and after setting, at least a 10% increase in volume compared to the preset composition when setting occurs at a temperature of below 100° F. (37.8° C.), at a temperature below about 73° F. (23° C.), below 60° F. (15.6° C.) or at about 55° F. (12.8° C.) or below.", "Additionally, the increase in volume after setting can be at least 15% when setting occurs at a temperature of below 100° F. (37.8° C.), at a temperature below about 73° F. (23° C.), below 60° F. (15.6° C.) or at about 55° F. (12.8° C.) or below.", "Also, the increase in volume after setting can be at least 17% when setting occurs at a temperature of below 100° F. (37.8° C.), at a temperature below about 73° F. (23° C.), below 60° F. (15.6° C.) or at about 55° F. (12.8° C.) or below.", "Also, the cement composition can comprise calcium hydroxide present in an amount from about 0.1% to about 3.0% by weight of said Portland cement, and sodium bicarbonate present in an amount from about 0.01% to about 1.00% by weight of the Portland cement.", "In some embodiments the cement composition comprises calcium chloride in an amount from about 0.1% to about 5.0%, or from 0.5% to 2% by weight of the Portland cement.", "In another aspect the expansive cement composition consists essentially of: a Portland cement; a fluid loss additive; a calcium aluminate cement in an amount from about 0.5% to about 8.0% by weight of the Portland cement; a lithium compound in an amount from about 0.001% to about 0.500% by weight of the Portland cement; calcium sulfate; water; and one or more compound selected from the group consisting of calcium hydroxide, sodium bicarbonate, a set accelerator and a fluid loss additive.", "In a further embodiment, there is provided a method for cementing a casing in a bore of a well having a borehole wall, comprising placing a cement slurry of one of the above described expansive cement compositions between the casing and the borehole wall; wherein the borehole wall and the casing are at a temperature below about 100° F. (37.8° C.).", "Additionally, the borehole wall and the casing can be at a temperature below about 73° F. (23° C.).", "In some embodiments, the borehole wall and the casing can be below 60° F. (15.6° C.) or they can be at about 55° F. (12.8° C.) or below.", "Therefore, the present invention is well adapted to attain the ends and advantages mentioned, as well as those that are inherent therein.", "The particular embodiments disclosed above are illustrative only, as the present invention may be modified and practiced in different but equivalent manners apparent to those skilled in the art having the benefit of the teachings herein.", "Furthermore, no limitations are intended to the details of construction or design herein shown, other than as described in the claims below.", "It is therefore evident that the particular illustrative embodiments disclosed above may be altered or modified, and all such variations are considered within the scope and spirit of the present invention.", "While compositions and methods are described in terms of “comprising,” “containing,” “having,” or “including” various components or steps, the compositions and methods can also “consist essentially of” or “consist of” the various components and steps.", "Whenever a numerical range with a lower limit and an upper limit is disclosed, any number and any included range falling within the range are specifically disclosed.", "In particular, every range of values (of the form, “from about a to about b,” or, equivalently, “from approximately a to b,” or, equivalently, “from approximately a-b”) disclosed herein is to be understood to set forth every number and range encompassed within the broader range of values.", "Also, the terms in the claims have their plain, ordinary meaning unless otherwise explicitly and clearly defined by the patentee." ] ]
Patent_15872641
[ [ "METHOD AND APPARATUS FOR DISTRIBUTING SOFTWARE", "Aspects of the subject disclosure may include, for example, a first network device receiving from a second network device a software, the first network device adjusting operations at the first network device according to the software, the first network device providing a digital signature to the software to generate an adjusted software where the digital signature indicates that the first network device has received the software, and the first network device transmitting, to a third network device, the adjusted software.", "Other embodiments are disclosed." ], [ "1.A first waveguide system comprising: a processor; and a memory that stores executable instructions that, when executed by the processor, facilitate performance of operations, the operations comprising: receiving, from a second waveguide system, first electromagnetic waves via a transmission medium, wherein the first electromagnetic waves are guided by the transmission medium without requiring an electrical return path, wherein the first electromagnetic waves convey data associated with a software program, wherein the software program is received by the first waveguide system from the second waveguide system without being received directly from a network source server that originated the software program, wherein a hierarchical configuration of the first waveguide system and the second waveguide system is dynamically organized such that the second waveguide system is designated as a root node, for distribution of the software program, for a group of elements comprising the first waveguide system; and adjusting the operations at the first waveguide system utilizing the software program.", "2.The first waveguide system of claim 1, wherein the operations further comprise: transmitting, to a third waveguide system, second electromagnetic waves via the transmission medium, wherein the second electromagnetic waves are guided by the transmission medium without requiring the electrical return path, and wherein the second electromagnetic waves convey the data; and providing a digital signature to the data being transmitted to the third waveguide system, wherein the digital signature indicates that the first waveguide system has received the software program.", "3.The first waveguide system of claim 2, wherein the software program comprises a software program update associated with an existing software program at the first waveguide system, wherein the data received from the second waveguide system includes another digital signature indicating that the second waveguide system received the software program update.", "4.The first waveguide system of claim 2, wherein the first waveguide system is an adjacent node to the second waveguide system and to the third waveguide system, and wherein the adjusting of the operations at the first waveguide system comprises adjusting an operating system of the first waveguide system according to the software program.", "5.The first waveguide system of claim 2, wherein the group of elements further comprises the third waveguide system.", "6.The first waveguide system of claim 1, wherein the operations further comprise: determining an applicability of the software program to the operations of the first waveguide system, wherein the adjusting of the operations at the first waveguide system is responsive to a determination that the software program is applicable to the operations of the first waveguide system.", "7.The first waveguide system of claim 1, wherein the operations further comprise: transmitting, to the second waveguide system, second electromagnetic waves via the transmission medium, wherein the second electromagnetic waves are guided by the transmission medium without requiring the electrical return path, and wherein the second electromagnetic waves convey an update request, wherein the receiving of the software program is responsive to the transmitting of the update request.", "8.The first waveguide system of claim 1, wherein the first waveguide system and the second waveguide system are adjacent nodes in a wired network comprising power lines that are the transmission medium, and wherein the second waveguide system receives the data from the network source server that originated the software program.", "9.A method comprising: dynamically organizing a hierarchical configuration of a first waveguide system and a second waveguide system such that the second waveguide system is designated as a root node, for distribution of a first software program, for a group of elements comprising the first waveguide system; authenticating, by the first waveguide system, the second waveguide system according to authentication information received from the second waveguide system; responsive to an authentication of the second waveguide system, receiving, by the first waveguide system from the second waveguide system, the first software program; adjusting operations at the first waveguide system according to the first software program; providing, by the first waveguide system, a digital signature to the first software program to generate an adjusted software program, wherein the digital signature indicates that the first waveguide system has received first the software program; and transmitting, to a third waveguide system, the adjusted software program.", "10.The method of claim 9, wherein the first, second and third waveguide systems transmit and receive electromagnetic waves at a physical interface of a transmission medium, wherein the electromagnetic waves are guided by the transmission medium without requiring an electrical return path, and wherein the authentication information, the first software program and the adjusted software program are conveyed via the electromagnetic waves.", "11.The method of claim 9, wherein the first waveguide system is an adjacent node to the second and third waveguide systems, and wherein the method further comprises: authenticating, by the first waveguide system, a fourth waveguide system according to other authentication information received from the fourth waveguide system; responsive to another authentication of the fourth waveguide system, receiving, by the first waveguide system from the fourth waveguide system, a second software program; and comparing the second software program with the first software program; wherein the adjusting of the operations at the first waveguide system according to the first software program is responsive to a determination that the first software program is a later version than the second software program.", "12.The method of claim 9, further comprising: transmitting, by the first waveguide system, an update request to the group of elements including a fourth waveguide system, wherein the transmitting of the update request does not include providing the update request to a network source server that originated the first software program; and determining, by the first waveguide system, a latest version of the first software program being stored by each element of the group of elements, wherein the receiving of the first software program is responsive to a determination that the second waveguide system has a latest version of the first software program.", "13.The method of claim 9, wherein the first software program comprises a software program update associated with an existing software program at the first waveguide system, and wherein the method further comprises determining an applicability of the software program update to the operations of the first waveguide system, wherein the adjusting of the operations at the first waveguide system is responsive to a determination that the software program update is applicable to the operations of the first waveguide system, and wherein the adjusting of the operations at the first waveguide system comprises adjusting an operating system of the first waveguide system according to the first software program.", "14.The method of claim 9, further comprising: identifying a plurality of waveguide systems from a plurality of digital signatures included with the first software program, wherein the plurality of digital signatures includes a second digital signature of the second waveguide system; and comparing the plurality of waveguide systems to expected waveguide systems along an expected communication path of the first software program, wherein the adjusting of the operations at the first waveguide system according to the first software program is responsive to a determination that the plurality of waveguide systems matches the expected waveguide systems along the expected communication path.", "15.The method of claim 9, wherein the first waveguide system is a child of the second waveguide system and the third waveguide system is a child of the first waveguide system.", "16.The method of claim 9, further comprising: monitoring, by the first waveguide system, for an expiration of an existing software program operating at the first waveguide system; and responsive to a determination that the existing software program has expired, transmitting, by the first waveguide system, an update request to the second waveguide system, wherein the transmitting of the update request does not include providing the update request to a network source server that originated the first software program, wherein the receiving of the first software program is responsive to the update request.", "17.A non-transitory machine-readable storage medium comprising instructions which, when executed by a processor of a first waveguide system, cause the processor to perform operations, the operations comprising: dynamically organizing a hierarchical configuration of the first waveguide system, a second waveguide system and a third waveguide system such that the second waveguide system is designated as a root node, for distribution of a first software program, for a group of elements comprising the first and third waveguide systems; monitoring for an expiration of an existing software program operating at the first waveguide system; responsive to a determination that the existing software program has expired, transmitting an update request to each of the second and third waveguide systems; responsive to the update request transmitted to each of the second and third waveguide systems, receiving the first software program from the second waveguide system and a second software program from the third waveguide system; comparing the first and second software programs; and responsive to a determination that the first software program is a later version than the second software program, adjusting operations at the first waveguide system according to the first software program, wherein the transmitting of the update request to each of the second and third waveguide systems does not include providing the update request to a network source server that originated the first software program.", "18.The non-transitory machine-readable storage medium of claim 17, wherein the adjusting of the operations at the first waveguide system comprises adjusting a communications protocol implemented by the first waveguide system, and wherein the operations further comprise: providing a digital signature to the first software program to generate an adjusted software program, wherein the digital signature indicates that the first waveguide system has received the first software program; and transmitting, to a fourth waveguide system, the adjusted software program.", "19.The non-transitory machine-readable storage medium of claim 18, wherein the operations further comprise: authenticating the fourth waveguide system according to authentication information received from the fourth waveguide system, wherein the transmitting of the adjusted software program is responsive to the authenticating.", "20.The non-transitory machine-readable storage medium of claim 17, wherein the first waveguide system transmits and receives electromagnetic waves at a physical interface of a transmission medium, and wherein the electromagnetic waves are guided by the transmission medium without requiring an electrical return path." ], [ "<SOH> BACKGROUND <EOH>As smart phones and other portable devices increasingly become ubiquitous, and data usage increases, macrocell base station devices and existing wireless infrastructure in turn require higher bandwidth capability in order to address the increased demand.", "To provide additional mobile bandwidth, small cell deployment is being pursued, with microcells and picocells providing coverage for much smaller areas than traditional macrocells.", "In addition, most homes and businesses have grown to rely on broadband data access for services such as voice, video and Internet browsing, etc.", "Broadband access networks include satellite, 4G or 5G wireless, power line communication, fiber, cable, and telephone networks." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>Reference will now be made to the accompanying drawings, which are not necessarily drawn to scale, and wherein: FIG.", "1 is a block diagram illustrating an example, non-limiting embodiment of a guided-wave communications system in accordance with various aspects described herein.", "FIG.", "2 is a block diagram illustrating an example, non-limiting embodiment of a transmission device in accordance with various aspects described herein.", "FIG.", "3 is a graphical diagram illustrating an example, non-limiting embodiment of an electromagnetic field distribution in accordance with various aspects described herein.", "FIG.", "4 is a graphical diagram illustrating an example, non-limiting embodiment of an electromagnetic field distribution in accordance with various aspects described herein.", "FIG.", "5A is a graphical diagram illustrating an example, non-limiting embodiment of a frequency response in accordance with various aspects described herein.", "FIG.", "5B is a graphical diagram illustrating example, non-limiting embodiments of a longitudinal cross-section of an insulated wire depicting fields of guided electromagnetic waves at various operating frequencies in accordance with various aspects described herein.", "FIG.", "6 is a graphical diagram illustrating an example, non-limiting embodiment of an electromagnetic field distribution in accordance with various aspects described herein.", "FIG.", "7 is a block diagram illustrating an example, non-limiting embodiment of an arc coupler in accordance with various aspects described herein.", "FIG.", "8 is a block diagram illustrating an example, non-limiting embodiment of an arc coupler in accordance with various aspects described herein.", "FIG.", "9A is a block diagram illustrating an example, non-limiting embodiment of a stub coupler in accordance with various aspects described herein.", "FIG.", "9B is a diagram illustrating an example, non-limiting embodiment of an electromagnetic distribution in accordance with various aspects described herein.", "FIGS.", "10A and 10B are block diagrams illustrating example, non-limiting embodiments of couplers and transceivers in accordance with various aspects described herein.", "FIG.", "11 is a block diagram illustrating an example, non-limiting embodiment of a dual stub coupler in accordance with various aspects described herein.", "FIG.", "12 is a block diagram illustrating an example, non-limiting embodiment of a repeater system in accordance with various aspects described herein.", "FIG.", "13 illustrates a block diagram illustrating an example, non-limiting embodiment of a bidirectional repeater in accordance with various aspects described herein.", "FIG.", "14 is a block diagram illustrating an example, non-limiting embodiment of a waveguide system in accordance with various aspects described herein.", "FIG.", "15 is a block diagram illustrating an example, non-limiting embodiment of a guided-wave communications system in accordance with various aspects described herein.", "FIGS.", "16A & 16B are block diagrams illustrating an example, non-limiting embodiment of a system for managing a power grid communication system in accordance with various aspects described herein.", "FIG.", "17A illustrates a flow diagram of an example, non-limiting embodiment of a method for detecting and mitigating disturbances occurring in a communication network of the system of FIGS.", "16A and 16B .", "FIG.", "17B illustrates a flow diagram of an example, non-limiting embodiment of a method for detecting and mitigating disturbances occurring in a communication network of the system of FIGS.", "16A and 16B .", "FIG.", "18 is a block diagram illustrating an example, non-limiting embodiment of a guided-wave communications system that implements a de-centralized software distribution process in accordance with various aspects described herein.", "FIG.", "19 illustrates a block diagram illustrating another example, non-limiting embodiment of a guided-wave communications system that implements a de-centralized software distribution process in accordance with various aspects described herein.", "FIG.", "20 illustrates a flow diagram of an example, non-limiting embodiment of a method of distributing software in accordance with various aspects described herein.", "FIG.", "21 is a block diagram of an example, non-limiting embodiment of a computing environment in accordance with various aspects described herein.", "FIG.", "22 is a block diagram of an example, non-limiting embodiment of a mobile network platform in accordance with various aspects described herein.", "FIG.", "23 is a block diagram of an example, non-limiting embodiment of a communication device in accordance with various aspects described herein.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATION(S) This application is a Continuation of U.S. patent application Ser.", "No.", "14/853,297, filed on Sep. 14, 2015.All sections of the aforementioned application(s) are incorporated herein by reference in their entirety.", "FIELD OF THE DISCLOSURE The subject disclosure relates to a method and apparatus for distributing software.", "BACKGROUND As smart phones and other portable devices increasingly become ubiquitous, and data usage increases, macrocell base station devices and existing wireless infrastructure in turn require higher bandwidth capability in order to address the increased demand.", "To provide additional mobile bandwidth, small cell deployment is being pursued, with microcells and picocells providing coverage for much smaller areas than traditional macrocells.", "In addition, most homes and businesses have grown to rely on broadband data access for services such as voice, video and Internet browsing, etc.", "Broadband access networks include satellite, 4G or 5G wireless, power line communication, fiber, cable, and telephone networks.", "BRIEF DESCRIPTION OF THE DRAWINGS Reference will now be made to the accompanying drawings, which are not necessarily drawn to scale, and wherein: FIG.", "1 is a block diagram illustrating an example, non-limiting embodiment of a guided-wave communications system in accordance with various aspects described herein.", "FIG.", "2 is a block diagram illustrating an example, non-limiting embodiment of a transmission device in accordance with various aspects described herein.", "FIG.", "3 is a graphical diagram illustrating an example, non-limiting embodiment of an electromagnetic field distribution in accordance with various aspects described herein.", "FIG.", "4 is a graphical diagram illustrating an example, non-limiting embodiment of an electromagnetic field distribution in accordance with various aspects described herein.", "FIG.", "5A is a graphical diagram illustrating an example, non-limiting embodiment of a frequency response in accordance with various aspects described herein.", "FIG.", "5B is a graphical diagram illustrating example, non-limiting embodiments of a longitudinal cross-section of an insulated wire depicting fields of guided electromagnetic waves at various operating frequencies in accordance with various aspects described herein.", "FIG.", "6 is a graphical diagram illustrating an example, non-limiting embodiment of an electromagnetic field distribution in accordance with various aspects described herein.", "FIG.", "7 is a block diagram illustrating an example, non-limiting embodiment of an arc coupler in accordance with various aspects described herein.", "FIG.", "8 is a block diagram illustrating an example, non-limiting embodiment of an arc coupler in accordance with various aspects described herein.", "FIG.", "9A is a block diagram illustrating an example, non-limiting embodiment of a stub coupler in accordance with various aspects described herein.", "FIG.", "9B is a diagram illustrating an example, non-limiting embodiment of an electromagnetic distribution in accordance with various aspects described herein.", "FIGS.", "10A and 10B are block diagrams illustrating example, non-limiting embodiments of couplers and transceivers in accordance with various aspects described herein.", "FIG.", "11 is a block diagram illustrating an example, non-limiting embodiment of a dual stub coupler in accordance with various aspects described herein.", "FIG.", "12 is a block diagram illustrating an example, non-limiting embodiment of a repeater system in accordance with various aspects described herein.", "FIG.", "13 illustrates a block diagram illustrating an example, non-limiting embodiment of a bidirectional repeater in accordance with various aspects described herein.", "FIG.", "14 is a block diagram illustrating an example, non-limiting embodiment of a waveguide system in accordance with various aspects described herein.", "FIG.", "15 is a block diagram illustrating an example, non-limiting embodiment of a guided-wave communications system in accordance with various aspects described herein.", "FIGS.", "16A & 16B are block diagrams illustrating an example, non-limiting embodiment of a system for managing a power grid communication system in accordance with various aspects described herein.", "FIG.", "17A illustrates a flow diagram of an example, non-limiting embodiment of a method for detecting and mitigating disturbances occurring in a communication network of the system of FIGS.", "16A and 16B.", "FIG.", "17B illustrates a flow diagram of an example, non-limiting embodiment of a method for detecting and mitigating disturbances occurring in a communication network of the system of FIGS.", "16A and 16B.", "FIG.", "18 is a block diagram illustrating an example, non-limiting embodiment of a guided-wave communications system that implements a de-centralized software distribution process in accordance with various aspects described herein.", "FIG.", "19 illustrates a block diagram illustrating another example, non-limiting embodiment of a guided-wave communications system that implements a de-centralized software distribution process in accordance with various aspects described herein.", "FIG.", "20 illustrates a flow diagram of an example, non-limiting embodiment of a method of distributing software in accordance with various aspects described herein.", "FIG.", "21 is a block diagram of an example, non-limiting embodiment of a computing environment in accordance with various aspects described herein.", "FIG.", "22 is a block diagram of an example, non-limiting embodiment of a mobile network platform in accordance with various aspects described herein.", "FIG.", "23 is a block diagram of an example, non-limiting embodiment of a communication device in accordance with various aspects described herein.", "DETAILED DESCRIPTION One or more embodiments are now described with reference to the drawings, wherein like reference numerals are used to refer to like elements throughout.", "In the following description, for purposes of explanation, numerous details are set forth in order to provide a thorough understanding of the various embodiments.", "It is evident, however, that the various embodiments can be practiced without these details (and without applying to any particular networked environment or standard).", "In an embodiment, a guided wave communication system is presented for sending and receiving communication signals such as data or other signaling via guided electromagnetic waves.", "The guided electromagnetic waves include, for example, surface waves or other electromagnetic waves that are bound to or guided by a transmission medium.", "It will be appreciated that a variety of transmission media can be utilized with guided wave communications without departing from example embodiments.", "Examples of such transmission media can include one or more of the following, either alone or in one or more combinations: wires, whether insulated or not, and whether single-stranded or multi-stranded; conductors of other shapes or configurations including wire bundles, cables, rods, rails, pipes; non-conductors such as dielectric pipes, rods, rails, or other dielectric members; combinations of conductors and dielectric materials; or other guided wave transmission media.", "The inducement of guided electromagnetic waves on a transmission medium can be independent of any electrical potential, charge or current that is injected or otherwise transmitted through the transmission medium as part of an electrical circuit.", "For example, in the case where the transmission medium is a wire, it is to be appreciated that while a small current in the wire may be formed in response to the propagation of the guided waves along the wire, this can be due to the propagation of the electromagnetic wave along the wire surface, and is not formed in response to electrical potential, charge or current that is injected into the wire as part of an electrical circuit.", "The electromagnetic waves traveling on the wire therefore do not require a circuit to propagate along the wire surface.", "The wire therefore is a single wire transmission line that is not part of a circuit.", "Also, in some embodiments, a wire is not necessary, and the electromagnetic waves can propagate along a single line transmission medium that is not a wire.", "More generally, “guided electromagnetic waves” or “guided waves” as described by the subject disclosure are affected by the presence of a physical object that is at least a part of the transmission medium (e.g., a bare wire or other conductor, a dielectric, an insulated wire, a conduit or other hollow element, a bundle of insulated wires that is coated, covered or surrounded by a dielectric or insulator or other wire bundle, or another form of solid, liquid or otherwise non-gaseous transmission medium) so as to be at least partially bound to or guided by the physical object and so as to propagate along a transmission path of the physical object.", "Such a physical object can operate as at least a part of a transmission medium that guides, by way of an interface of the transmission medium (e.g., an outer surface, inner surface, an interior portion between the outer and the inner surfaces or other boundary between elements of the transmission medium), the propagation of guided electromagnetic waves, which in turn can carry energy, data and/or other signals along the transmission path from a sending device to a receiving device.", "Unlike free space propagation of wireless signals such as unguided (or unbounded) electromagnetic waves that decrease in intensity inversely by the square of the distance traveled by the unguided electromagnetic waves, guided electromagnetic waves can propagate along a transmission medium with less loss in magnitude per unit distance than experienced by unguided electromagnetic waves.", "Unlike electrical signals, guided electromagnetic waves can propagate from a sending device to a receiving device without requiring a separate electrical return path between the sending device and the receiving device.", "As a consequence, guided electromagnetic waves can propagate from a sending device to a receiving device along a transmission medium having no conductive components (e.g., a dielectric strip), or via a transmission medium having no more than a single conductor (e.g., a single bare wire or insulated wire).", "Even if a transmission medium includes one or more conductive components and the guided electromagnetic waves propagating along the transmission medium generate currents that flow in the one or more conductive components in a direction of the guided electromagnetic waves, such guided electromagnetic waves can propagate along the transmission medium from a sending device to a receiving device without requiring a flow of opposing currents on an electrical return path between the sending device and the receiving device.", "In a non-limiting illustration, consider electrical systems that transmit and receive electrical signals between sending and receiving devices by way of conductive media.", "Such systems generally rely on electrically separate forward and return paths.", "For instance, consider a coaxial cable having a center conductor and a ground shield that are separated by an insulator.", "Typically, in an electrical system a first terminal of a sending (or receiving) device can be connected to the center conductor, and a second terminal of the sending (or receiving) device can be connected to the ground shield.", "If the sending device injects an electrical signal in the center conductor via the first terminal, the electrical signal will propagate along the center conductor causing forward currents in the center conductor, and return currents in the ground shield.", "The same conditions apply for a two terminal receiving device.", "In contrast, consider a guided wave communication system such as described in the subject disclosure, which can utilize different embodiments of a transmission medium (including among others a coaxial cable) for transmitting and receiving guided electromagnetic waves without an electrical return path.", "In one embodiment, for example, the guided wave communication system of the subject disclosure can be configured to induce guided electromagnetic waves that propagate along an outer surface of a coaxial cable.", "Although the guided electromagnetic waves will cause forward currents on the ground shield, the guided electromagnetic waves do not require return currents to enable the guided electromagnetic waves to propagate along the outer surface of the coaxial cable.", "The same can be said of other transmission media used by a guided wave communication system for the transmission and reception of guided electromagnetic waves.", "For example, guided electromagnetic waves induced by the guided wave communication system on an outer surface of a bare wire, or an insulated wire can propagate along the bare wire or the insulated bare wire without an electrical return path.", "Consequently, electrical systems that require two or more conductors for carrying forward and reverse currents on separate conductors to enable the propagation of electrical signals injected by a sending device are distinct from guided wave systems that induce guided electromagnetic waves on an interface of a transmission medium without the need of an electrical return path to enable the propagation of the guided electromagnetic waves along the interface of the transmission medium.", "It is further noted that guided electromagnetic waves as described in the subject disclosure can have an electromagnetic field structure that lies primarily or substantially outside of a transmission medium so as to be bound to or guided by the transmission medium and so as to propagate non-trivial distances on or along an outer surface of the transmission medium.", "In other embodiments, guided electromagnetic waves can have an electromagnetic field structure that lies primarily or substantially inside a transmission medium so as to be bound to or guided by the transmission medium and so as to propagate non-trivial distances within the transmission medium.", "In other embodiments, guided electromagnetic waves can have an electromagnetic field structure that lies partially inside and partially outside a transmission medium so as to be bound to or guided by the transmission medium and so as to propagate non-trivial distances along the transmission medium.", "The desired electronic field structure in an embodiment may vary based upon a variety of factors, including the desired transmission distance, the characteristics of the transmission medium itself, and environmental conditions/characteristics outside of the transmission medium (e.g., presence of rain, fog, atmospheric conditions, etc.).", "Various embodiments described herein relate to coupling devices, that can be referred to as “waveguide coupling devices”, “waveguide couplers” or more simply as “couplers”, “coupling devices” or “launchers” for launching and/or extracting guided electromagnetic waves to and from a transmission medium at millimeter-wave frequencies (e.g., 30 to 300 GHz), wherein the wavelength can be small compared to one or more dimensions of the coupling device and/or the transmission medium such as the circumference of a wire or other cross sectional dimension, or lower microwave frequencies such as 300 MHz to 30 GHz.", "Transmissions can be generated to propagate as waves guided by a coupling device, such as: a strip, arc or other length of dielectric material; a horn, monopole, rod, slot or other antenna; an array of antennas; a magnetic resonant cavity, or other resonant coupler; a coil, a strip line, a waveguide or other coupling device.", "In operation, the coupling device receives an electromagnetic wave from a transmitter or transmission medium.", "The electromagnetic field structure of the electromagnetic wave can be carried inside the coupling device, outside the coupling device or some combination thereof.", "When the coupling device is in close proximity to a transmission medium, at least a portion of an electromagnetic wave couples to or is bound to the transmission medium, and continues to propagate as guided electromagnetic waves.", "In a reciprocal fashion, a coupling device can extract guided waves from a transmission medium and transfer these electromagnetic waves to a receiver.", "According to an example embodiment, a surface wave is a type of guided wave that is guided by a surface of a transmission medium, such as an exterior or outer surface of the wire, or another surface of the wire that is adjacent to or exposed to another type of medium having different properties (e.g., dielectric properties).", "Indeed, in an example embodiment, a surface of the wire that guides a surface wave can represent a transitional surface between two different types of media.", "For example, in the case of a bare or uninsulated wire, the surface of the wire can be the outer or exterior conductive surface of the bare or uninsulated wire that is exposed to air or free space.", "As another example, in the case of insulated wire, the surface of the wire can be the conductive portion of the wire that meets the insulator portion of the wire, or can otherwise be the insulator surface of the wire that is exposed to air or free space, or can otherwise be any material region between the insulator surface of the wire and the conductive portion of the wire that meets the insulator portion of the wire, depending upon the relative differences in the properties (e.g., dielectric properties) of the insulator, air, and/or the conductor and further dependent on the frequency and propagation mode or modes of the guided wave.", "According to an example embodiment, the term “about” a wire or other transmission medium used in conjunction with a guided wave can include fundamental guided wave propagation modes such as a guided waves having a circular or substantially circular field distribution, a symmetrical electromagnetic field distribution (e.g., electric field, magnetic field, electromagnetic field, etc.)", "or other fundamental mode pattern at least partially around a wire or other transmission medium.", "In addition, when a guided wave propagates “about” a wire or other transmission medium, it can do so according to a guided wave propagation mode that includes not only the fundamental wave propagation modes (e.g., zero order modes), but additionally or alternatively non-fundamental wave propagation modes such as higher-order guided wave modes (e.g., 1st order modes, 2nd order modes, etc.", "), asymmetrical modes and/or other guided (e.g., surface) waves that have non-circular field distributions around a wire or other transmission medium.", "As used herein, the term “guided wave mode” refers to a guided wave propagation mode of a transmission medium, coupling device or other system component of a guided wave communication system.", "For example, such non-circular field distributions can be unilateral or multi-lateral with one or more axial lobes characterized by relatively higher field strength and/or one or more nulls or null regions characterized by relatively low-field strength, zero-field strength or substantially zero-field strength.", "Further, the field distribution can otherwise vary as a function of azimuthal orientation around the wire such that one or more angular regions around the wire have an electric or magnetic field strength (or combination thereof) that is higher than one or more other angular regions of azimuthal orientation, according to an example embodiment.", "It will be appreciated that the relative orientations or positions of the guided wave higher order modes or asymmetrical modes can vary as the guided wave travels along the wire.", "As used herein, the term “millimeter-wave” can refer to electromagnetic waves/signals that fall within the “millimeter-wave frequency band” of 30 GHz to 300 GHz.", "The term “microwave” can refer to electromagnetic waves/signals that fall within a “microwave frequency band” of 300 MHz to 300 GHz.", "The term “radio frequency” or “RF” can refer to electromagnetic waves/signals that fall within the “radio frequency band” of 10 kHz to 1 THz.", "It is appreciated that wireless signals, electrical signals, and guided electromagnetic waves as described in the subject disclosure can be configured to operate at any desirable frequency range, such as, for example, at frequencies within, above or below millimeter-wave and/or microwave frequency bands.", "In particular, when a coupling device or transmission medium includes a conductive element, the frequency of the guided electromagnetic waves that are carried by the coupling device and/or propagate along the transmission medium can be below the mean collision frequency of the electrons in the conductive element.", "Further, the frequency of the guided electromagnetic waves that are carried by the coupling device and/or propagate along the transmission medium can be a non-optical frequency, e.g.", "a radio frequency below the range of optical frequencies that begins at 1 THz.", "As used herein, the term “antenna” can refer to a device that is part of a transmitting or receiving system to transmit/radiate or receive wireless signals.", "In accordance with one or more embodiments, a waveguide system includes a processor and a memory that stores executable instructions that, when executed by the processor, facilitate performance of operations, including receiving, from a second waveguide system, first electromagnetic waves via a transmission medium, where the first electromagnetic waves are guided by the transmission medium without utilizing an electrical return path, where the first electromagnetic waves have a non-optical frequency range, where the first electromagnetic waves convey data, where the data comprises a software, and where the software is received by the waveguide system from the second waveguide system without being received directly from a network source server that originated the software.", "The waveguide system can adjust operations at the waveguide system according to the software.", "In one embodiment, the waveguide system can also transmit, to a third waveguide system, second electromagnetic waves via the transmission medium, where the second electromagnetic waves are guided by the transmission medium without utilizing the electrical return path, where the second electromagnetic waves have the non-optical frequency range, and where the second electromagnetic waves convey the data.", "In accordance with one or more embodiments, a method includes authenticating, by a first network device, a second network device according to authentication information received from the second network device.", "The method includes responsive to an authentication of the second network device, receiving, by the first network device from the second network device, a software; and adjusting operations at the first network device according to the software.", "The method includes providing, by the first network device, a digital signature to the software to generate an adjusted software, where the digital signature indicates that the first network device has received the software.", "The method includes transmitting, to a third network device, the adjusted software.", "In accordance with one or more embodiments, a machine-readable storage device includes instructions, which when executed by a processor of a network device cause the processor to perform operations including monitoring for an expiration of software operating at the first network device and, responsive to a determination that the software has expired, transmitting update requests to a group of network devices.", "The processor can, responsive to the update requests, receive first and second softwares from the group of network devices.", "The processor can compare the first and second software.", "The processor can, responsive to a determination that the first software is a later version than the second software, adjust operations at the first network device according to the first software.", "The transmitting of the update requests does not include providing the update requests to a network source server that originated the first software.", "Referring now to FIG.", "1, a block diagram 100 illustrating an example, non-limiting embodiment of a guided wave communications system is shown.", "In operation, a transmission device 101 receives one or more communication signals 110 from a communication network or other communications device that includes data and generates guided waves 120 to convey the data via the transmission medium 125 to the transmission device 102.The transmission device 102 receives the guided waves 120 and converts them to communication signals 112 that include the data for transmission to a communications network or other communications device.", "The guided waves 120 can be modulated to convey data via a modulation technique such as phase shift keying, frequency shift keying, quadrature amplitude modulation, amplitude modulation, multi-carrier modulation such as orthogonal frequency division multiplexing and via multiple access techniques such as frequency division multiplexing, time division multiplexing, code division multiplexing, multiplexing via differing wave propagation modes and via other modulation and access strategies.", "The communication network or networks can include a wireless communication network such as a mobile data network, a cellular voice and data network, a wireless local area network (e.g., WiFi or an 802.xx network), a satellite communications network, a personal area network or other wireless network.", "The communication network or networks can also include a wired communication network such as a telephone network, an Ethernet network, a local area network, a wide area network such as the Internet, a broadband access network, a cable network, a fiber optic network, or other wired network.", "The communication devices can include a network edge device, bridge device or home gateway, a set-top box, broadband modem, telephone adapter, access point, base station, or other fixed communication device, a mobile communication device such as an automotive gateway or automobile, laptop computer, tablet, smartphone, cellular telephone, or other communication device.", "In an example embodiment, the guided wave communication system 100 can operate in a bi-directional fashion where transmission device 102 receives one or more communication signals 112 from a communication network or device that includes other data and generates guided waves 122 to convey the other data via the transmission medium 125 to the transmission device 101.In this mode of operation, the transmission device 101 receives the guided waves 122 and converts them to communication signals 110 that include the other data for transmission to a communications network or device.", "The guided waves 122 can be modulated to convey data via a modulation technique such as phase shift keying, frequency shift keying, quadrature amplitude modulation, amplitude modulation, multi-carrier modulation such as orthogonal frequency division multiplexing and via multiple access techniques such as frequency division multiplexing, time division multiplexing, code division multiplexing, multiplexing via differing wave propagation modes and via other modulation and access strategies.", "The transmission medium 125 can include a cable having at least one inner portion surrounded by a dielectric material such as an insulator or other dielectric cover, coating or other dielectric material, the dielectric material having an outer surface and a corresponding circumference.", "In an example embodiment, the transmission medium 125 operates as a single-wire transmission line to guide the transmission of an electromagnetic wave.", "When the transmission medium 125 is implemented as a single wire transmission system, it can include a wire.", "The wire can be insulated or uninsulated, and single-stranded or multi-stranded (e.g., braided).", "In other embodiments, the transmission medium 125 can contain conductors of other shapes or configurations including wire bundles, cables, rods, rails, pipes.", "In addition, the transmission medium 125 can include non-conductors such as dielectric pipes, rods, rails, or other dielectric members; combinations of conductors and dielectric materials, conductors without dielectric materials or other guided wave transmission media.", "It should be noted that the transmission medium 125 can otherwise include any of the transmission media previously discussed.", "Further, as previously discussed, the guided waves 120 and 122 can be contrasted with radio transmissions over free space/air or conventional propagation of electrical power or signals through the conductor of a wire via an electrical circuit.", "In addition to the propagation of guided waves 120 and 122, the transmission medium 125 may optionally contain one or more wires that propagate electrical power or other communication signals in a conventional manner as a part of one or more electrical circuits.", "Referring now to FIG.", "2, a block diagram 200 illustrating an example, non-limiting embodiment of a transmission device is shown.", "The transmission device 101 or 102 includes a communications interface (UF) 205, a transceiver 210 and a coupler 220.In an example of operation, the communications interface 205 receives a communication signal 110 or 112 that includes data.", "In various embodiments, the communications interface 205 can include a wireless interface for receiving a wireless communication signal in accordance with a wireless standard protocol such as LTE or other cellular voice and data protocol, WiFi or an 802.11 protocol, WIMAX protocol, Ultra Wideband protocol, Bluetooth protocol, Zigbee protocol, a direct broadcast satellite (DBS) or other satellite communication protocol or other wireless protocol.", "In addition or in the alternative, the communications interface 205 includes a wired interface that operates in accordance with an Ethernet protocol, universal serial bus (USB) protocol, a data over cable service interface specification (DOCSIS) protocol, a digital subscriber line (DSL) protocol, a Firewire (IEEE 1394) protocol, or other wired protocol.", "In additional to standards-based protocols, the communications interface 205 can operate in conjunction with other wired or wireless protocol.", "In addition, the communications interface 205 can optionally operate in conjunction with a protocol stack that includes multiple protocol layers including a MAC protocol, transport protocol, application protocol, etc.", "In an example of operation, the transceiver 210 generates an electromagnetic wave based on the communication signal 110 or 112 to convey the data.", "The electromagnetic wave has at least one carrier frequency and at least one corresponding wavelength.", "The carrier frequency can be within a millimeter-wave frequency band of 30 GHz-300 GHz, such as 60 GHz or a carrier frequency in the range of 30-40 GHz or a lower frequency band of 300 MHz-30 GHz in the microwave frequency range such as 26-30 GHz, 11 GHz, 6 GHz or 3 GHz, but it will be appreciated that other carrier frequencies are possible in other embodiments.", "In one mode of operation, the transceiver 210 merely upconverts the communications signal or signals 110 or 112 for transmission of the electromagnetic signal in the microwave or millimeter-wave band as a guided electromagnetic wave that is guided by or bound to the transmission medium 125.In another mode of operation, the communications interface 205 either converts the communication signal 110 or 112 to a baseband or near baseband signal or extracts the data from the communication signal 110 or 112 and the transceiver 210 modulates a high-frequency carrier with the data, the baseband or near baseband signal for transmission.", "It should be appreciated that the transceiver 210 can modulate the data received via the communication signal 110 or 112 to preserve one or more data communication protocols of the communication signal 110 or 112 either by encapsulation in the payload of a different protocol or by simple frequency shifting.", "In the alternative, the transceiver 210 can otherwise translate the data received via the communication signal 110 or 112 to a protocol that is different from the data communication protocol or protocols of the communication signal 110 or 112.In an example of operation, the coupler 220 couples the electromagnetic wave to the transmission medium 125 as a guided electromagnetic wave to convey the communications signal or signals 110 or 112.While the prior description has focused on the operation of the transceiver 210 as a transmitter, the transceiver 210 can also operate to receive electromagnetic waves that convey other data from the single wire transmission medium via the coupler 220 and to generate communications signals 110 or 112, via communications interface 205 that includes the other data.", "Consider embodiments where an additional guided electromagnetic wave conveys other data that also propagates along the transmission medium 125.The coupler 220 can also couple this additional electromagnetic wave from the transmission medium 125 to the transceiver 210 for reception.", "The transmission device 101 or 102 includes an optional training controller 230.In an example embodiment, the training controller 230 is implemented by a standalone processor or a processor that is shared with one or more other components of the transmission device 101 or 102.The training controller 230 selects the carrier frequencies, modulation schemes and/or guided wave modes for the guided electromagnetic waves based on feedback data received by the transceiver 210 from at least one remote transmission device coupled to receive the guided electromagnetic wave.", "In an example embodiment, a guided electromagnetic wave transmitted by a remote transmission device 101 or 102 conveys data that also propagates along the transmission medium 125.The data from the remote transmission device 101 or 102 can be generated to include the feedback data.", "In operation, the coupler 220 also couples the guided electromagnetic wave from the transmission medium 125 and the transceiver receives the electromagnetic wave and processes the electromagnetic wave to extract the feedback data.", "In an example embodiment, the training controller 230 operates based on the feedback data to evaluate a plurality of candidate frequencies, modulation schemes and/or transmission modes to select a carrier frequency, modulation scheme and/or transmission mode to enhance performance, such as throughput, signal strength, reduce propagation loss, etc.", "Consider the following example: a transmission device 101 begins operation under control of the training controller 230 by sending a plurality of guided waves as test signals such as pilot waves or other test signals at a corresponding plurality of candidate frequencies and/or candidate modes directed to a remote transmission device 102 coupled to the transmission medium 125.The guided waves can include, in addition or in the alternative, test data.", "The test data can indicate the particular candidate frequency and/or guide-wave mode of the signal.", "In an embodiment, the training controller 230 at the remote transmission device 102 receives the test signals and/or test data from any of the guided waves that were properly received and determines the best candidate frequency and/or guided wave mode, a set of acceptable candidate frequencies and/or guided wave modes, or a rank ordering of candidate frequencies and/or guided wave modes.", "This selection of candidate frequenc(ies) or/and guided-mode(s) are generated by the training controller 230 based on one or more optimizing criteria such as received signal strength, bit error rate, packet error rate, signal to noise ratio, propagation loss, etc.", "The training controller 230 generates feedback data that indicates the selection of candidate frequenc(ies) or/and guided wave mode(s) and sends the feedback data to the transceiver 210 for transmission to the transmission device 101.The transmission device 101 and 102 can then communicate data with one another based on the selection of candidate frequenc(ies) or/and guided wave mode(s).", "In other embodiments, the guided electromagnetic waves that contain the test signals and/or test data are reflected back, repeated back or otherwise looped back by the remote transmission device 102 to the transmission device 101 for reception and analysis by the training controller 230 of the transmission device 101 that initiated these waves.", "For example, the transmission device 101 can send a signal to the remote transmission device 102 to initiate a test mode where a physical reflector is switched on the line, a termination impedance is changed to cause reflections, a loop back mode is switched on to couple electromagnetic waves back to the source transmission device 102, and/or a repeater mode is enabled to amplify and retransmit the electromagnetic waves back to the source transmission device 102.The training controller 230 at the source transmission device 102 receives the test signals and/or test data from any of the guided waves that were properly received and determines selection of candidate frequenc(ies) or/and guided wave mode(s).", "While the procedure above has been described in a start-up or initialization mode of operation, each transmission device 101 or 102 can send test signals, evaluate candidate frequencies or guided wave modes via non-test such as normal transmissions or otherwise evaluate candidate frequencies or guided wave modes at other times or continuously as well.", "In an example embodiment, the communication protocol between the transmission devices 101 and 102 can include an on-request or periodic test mode where either full testing or more limited testing of a subset of candidate frequencies and guided wave modes are tested and evaluated.", "In other modes of operation, the re-entry into such a test mode can be triggered by a degradation of performance due to a disturbance, weather conditions, etc.", "In an example embodiment, the receiver bandwidth of the transceiver 210 is either sufficiently wide or swept to receive all candidate frequencies or can be selectively adjusted by the training controller 230 to a training mode where the receiver bandwidth of the transceiver 210 is sufficiently wide or swept to receive all candidate frequencies.", "Referring now to FIG.", "3, a graphical diagram 300 illustrating an example, non-limiting embodiment of an electromagnetic field distribution is shown.", "In this embodiment, a transmission medium 125 in air includes an inner conductor 301 and an insulating jacket 302 of dielectric material, as shown in cross section.", "The diagram 300 includes different gray-scales that represent differing electromagnetic field strengths generated by the propagation of the guided wave having an asymmetrical and non-fundamental guided wave mode.", "In particular, the electromagnetic field distribution corresponds to a modal “sweet spot” that enhances guided electromagnetic wave propagation along an insulated transmission medium and reduces end-to-end transmission loss.", "In this particular mode, electromagnetic waves are guided by the transmission medium 125 to propagate along an outer surface of the transmission medium—in this case, the outer surface of the insulating jacket 302.Electromagnetic waves are partially embedded in the insulator and partially radiating on the outer surface of the insulator.", "In this fashion, electromagnetic waves are “lightly” coupled to the insulator so as to enable electromagnetic wave propagation at long distances with low propagation loss.", "As shown, the guided wave has a field structure that lies primarily or substantially outside of the transmission medium 125 that serves to guide the electromagnetic waves.", "The regions inside the conductor 301 have little or no field.", "Likewise regions inside the insulating jacket 302 have low field strength.", "The majority of the electromagnetic field strength is distributed in the lobes 304 at the outer surface of the insulating jacket 302 and in close proximity thereof.", "The presence of an asymmetric guided wave mode is shown by the high electromagnetic field strengths at the top and bottom of the outer surface of the insulating jacket 302 (in the orientation of the diagram)—as opposed to very small field strengths on the other sides of the insulating jacket 302.The example shown corresponds to a 38 GHz electromagnetic wave guided by a wire with a diameter of 1.1 cm and a dielectric insulation of thickness of 0.36 cm.", "Because the electromagnetic wave is guided by the transmission medium 125 and the majority of the field strength is concentrated in the air outside of the insulating jacket 302 within a limited distance of the outer surface, the guided wave can propagate longitudinally down the transmission medium 125 with very low loss.", "In the example shown, this “limited distance” corresponds to a distance from the outer surface that is less than half the largest cross sectional dimension of the transmission medium 125.In this case, the largest cross sectional dimension of the wire corresponds to the overall diameter of 1.82 cm, however, this value can vary with the size and shape of the transmission medium 125.For example, should the transmission medium 125 be of a rectangular shape with a height of 0.3 cm and a width of 0.4 cm, the largest cross sectional dimension would be the diagonal of 0.5 cm and the corresponding limited distance would be 0.25 cm.", "The dimensions of the area containing the majority of the field strength also vary with the frequency, and in general, increase as carrier frequencies decrease.", "It should also be noted that the components of a guided wave communication system, such as couplers and transmission media can have their own cut-off frequencies for each guided wave mode.", "The cut-off frequency generally sets forth the lowest frequency that a particular guided wave mode is designed to be supported by that particular component.", "In an example embodiment, the particular asymmetric mode of propagation shown is induced on the transmission medium 125 by an electromagnetic wave having a frequency that falls within a limited range (such as Fc to 2Fc) of the lower cut-off frequency Fc for this particular asymmetric mode.", "The lower cut-off frequency Fc is particular to the characteristics of transmission medium 125.For embodiments as shown that include an inner conductor 301 surrounded by an insulating jacket 302, this cutoff frequency can vary based on the dimensions and properties of the insulating jacket 302 and potentially the dimensions and properties of the inner conductor 301 and can be determined experimentally to have a desired mode pattern.", "It should be noted however, that similar effects can be found for a hollow dielectric or insulator without an inner conductor.", "In this case, the cutoff frequency can vary based on the dimensions and properties of the hollow dielectric or insulator.", "At frequencies lower than the lower cut-off frequency, the asymmetric mode is difficult to induce in the transmission medium 125 and fails to propagate for all but trivial distances.", "As the frequency increases above the limited range of frequencies about the cut-off frequency, the asymmetric mode shifts more and more inward of the insulating jacket 302.At frequencies much larger than the cut-off frequency, the field strength is no longer concentrated outside of the insulating jacket, but primarily inside of the insulating jacket 302.While the transmission medium 125 provides strong guidance to the electromagnetic wave and propagation is still possible, ranges are more limited by increased losses due to propagation within the insulating jacket 302—as opposed to the surrounding air.", "Referring now to FIG.", "4, a graphical diagram 400 illustrating an example, non-limiting embodiment of an electromagnetic field distribution is shown.", "In particular, a cross section diagram 400, similar to FIG.", "3 is shown with common reference numerals used to refer to similar elements.", "The example shown corresponds to a 60 GHz wave guided by a wire with a diameter of 1.1 cm and a dielectric insulation of thickness of 0.36 cm.", "Because the frequency of the guided wave is above the limited range of the cut-off frequency of this particular asymmetric mode, much of the field strength has shifted inward of the insulating jacket 302.In particular, the field strength is concentrated primarily inside of the insulating jacket 302.While the transmission medium 125 provides strong guidance to the electromagnetic wave and propagation is still possible, ranges are more limited when compared with the embodiment of FIG.", "3, by increased losses due to propagation within the insulating jacket 302.Referring now to FIG.", "5A, a graphical diagram illustrating an example, non-limiting embodiment of a frequency response is shown.", "In particular, diagram 500 presents a graph of end-to-end loss (in dB) as a function of frequency, overlaid with electromagnetic field distributions 510, 520 and 530 at three points for a 200 cm insulated medium voltage wire.", "The boundary between the insulator and the surrounding air is represented by reference numeral 525 in each electromagnetic field distribution.", "As discussed in conjunction with FIG.", "3, an example of a desired asymmetric mode of propagation shown is induced on the transmission medium 125 by an electromagnetic wave having a frequency that falls within a limited range (such as Fc to 2Fc) of the lower cut-off frequency Fc of the transmission medium for this particular asymmetric mode.", "In particular, the electromagnetic field distribution 520 at 6 GHz falls within this modal “sweet spot” that enhances electromagnetic wave propagation along an insulated transmission medium and reduces end-to-end transmission loss.", "In this particular mode, guided waves are partially embedded in the insulator and partially radiating on the outer surface of the insulator.", "In this fashion, the electromagnetic waves are “lightly” coupled to the insulator so as to enable guided electromagnetic wave propagation at long distances with low propagation loss.", "At lower frequencies represented by the electromagnetic field distribution 510 at 3 GHz, the asymmetric mode radiates more heavily generating higher propagation losses.", "At higher frequencies represented by the electromagnetic field distribution 530 at 9 GHz, the asymmetric mode shifts more and more inward of the insulating jacket providing too much absorption, again generating higher propagation losses.", "Referring now to FIG.", "5B, a graphical diagram 550 illustrating example, non-limiting embodiments of a longitudinal cross-section of a transmission medium 125, such as an insulated wire, depicting fields of guided electromagnetic waves at various operating frequencies is shown.", "As shown in diagram 556, when the guided electromagnetic waves are at approximately the cutoff frequency (fc) corresponding to the modal “sweet spot”, the guided electromagnetic waves are loosely coupled to the insulated wire so that absorption is reduced, and the fields of the guided electromagnetic waves are bound sufficiently to reduce the amount radiated into the environment (e.g., air).", "Because absorption and radiation of the fields of the guided electromagnetic waves is low, propagation losses are consequently low, enabling the guided electromagnetic waves to propagate for longer distances.", "As shown in diagram 554, propagation losses increase when an operating frequency of the guide electromagnetic waves increases above about two-times the cutoff frequency (fc)—or as referred to, above the range of the “sweet spot”.", "More of the field strength of the electromagnetic wave is driven inside the insulating layer, increasing propagation losses.", "At frequencies much higher than the cutoff frequency (fc) the guided electromagnetic waves are strongly bound to the insulated wire as a result of the fields emitted by the guided electromagnetic waves being concentrated in the insulation layer of the wire, as shown in diagram 552.This in turn raises propagation losses further due to absorption of the guided electromagnetic waves by the insulation layer.", "Similarly, propagation losses increase when the operating frequency of the guided electromagnetic waves is substantially below the cutoff frequency (fc), as shown in diagram 558.At frequencies much lower than the cutoff frequency (fc) the guided electromagnetic waves are weakly (or nominally) bound to the insulated wire and thereby tend to radiate into the environment (e.g., air), which in turn, raises propagation losses due to radiation of the guided electromagnetic waves.", "Referring now to FIG.", "6, a graphical diagram 600 illustrating an example, non-limiting embodiment of an electromagnetic field distribution is shown.", "In this embodiment, a transmission medium 602 is a bare wire, as shown in cross section.", "The diagram 300 includes different gray-scales that represent differing electromagnetic field strengths generated by the propagation of a guided wave having a symmetrical and fundamental guided wave mode at a single carrier frequency.", "In this particular mode, electromagnetic waves are guided by the transmission medium 602 to propagate along an outer surface of the transmission medium—in this case, the outer surface of the bare wire.", "Electromagnetic waves are “lightly” coupled to the wire so as to enable electromagnetic wave propagation at long distances with low propagation loss.", "As shown, the guided wave has a field structure that lies substantially outside of the transmission medium 602 that serves to guide the electromagnetic waves.", "The regions inside the conductor 625 have little or no field.", "Referring now to FIG.", "7, a block diagram 700 illustrating an example, non-limiting embodiment of an arc coupler is shown.", "In particular a coupling device is presented for use in a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1.The coupling device includes an arc coupler 704 coupled to a transmitter circuit 712 and termination or damper 714.The arc coupler 704 can be made of a dielectric material, or other low-loss insulator (e.g., Teflon, polyethylene, etc.", "), or made of a conducting (e.g., metallic, non-metallic, etc.)", "material, or any combination of the foregoing materials.", "As shown, the arc coupler 704 operates as a waveguide and has a wave 706 propagating as a guided wave about a waveguide surface of the arc coupler 704.In the embodiment shown, at least a portion of the arc coupler 704 can be placed near a wire 702 or other transmission medium, (such as transmission medium 125), in order to facilitate coupling between the arc coupler 704 and the wire 702 or other transmission medium, as described herein to launch the guided wave 708 on the wire.", "The arc coupler 704 can be placed such that a portion of the curved arc coupler 704 is tangential to, and parallel or substantially parallel to the wire 702.The portion of the arc coupler 704 that is parallel to the wire can be an apex of the curve, or any point where a tangent of the curve is parallel to the wire 702.When the arc coupler 704 is positioned or placed thusly, the wave 706 travelling along the arc coupler 704 couples, at least in part, to the wire 702, and propagates as guided wave 708 around or about the wire surface of the wire 702 and longitudinally along the wire 702.The guided wave 708 can be characterized as a surface wave or other electromagnetic wave that is guided by or bound to the wire 702 or other transmission medium.", "A portion of the wave 706 that does not couple to the wire 702 propagates as a wave 710 along the arc coupler 704.It will be appreciated that the arc coupler 704 can be configured and arranged in a variety of positions in relation to the wire 702 to achieve a desired level of coupling or non-coupling of the wave 706 to the wire 702.For example, the curvature and/or length of the arc coupler 704 that is parallel or substantially parallel, as well as its separation distance (which can include zero separation distance in an embodiment), to the wire 702 can be varied without departing from example embodiments.", "Likewise, the arrangement of arc coupler 704 in relation to the wire 702 may be varied based upon considerations of the respective intrinsic characteristics (e.g., thickness, composition, electromagnetic properties, etc.)", "of the wire 702 and the arc coupler 704, as well as the characteristics (e.g., frequency, energy level, etc.)", "of the waves 706 and 708.The guided wave 708 stays parallel or substantially parallel to the wire 702, even as the wire 702 bends and flexes.", "Bends in the wire 702 can increase transmission losses, which are also dependent on wire diameters, frequency, and materials.", "If the dimensions of the arc coupler 704 are chosen for efficient power transfer, most of the power in the wave 706 is transferred to the wire 702, with little power remaining in wave 710.It will be appreciated that the guided wave 708 can still be multi-modal in nature (discussed herein), including having modes that are non-fundamental or asymmetric, while traveling along a path that is parallel or substantially parallel to the wire 702, with or without a fundamental transmission mode.", "In an embodiment, non-fundamental or asymmetric modes can be utilized to minimize transmission losses and/or obtain increased propagation distances.", "It is noted that the term parallel is generally a geometric construct which often is not exactly achievable in real systems.", "Accordingly, the term parallel as utilized in the subject disclosure represents an approximation rather than an exact configuration when used to describe embodiments disclosed in the subject disclosure.", "In an embodiment, substantially parallel can include approximations that are within 30 degrees of true parallel in all dimensions.", "In an embodiment, the wave 706 can exhibit one or more wave propagation modes.", "The arc coupler modes can be dependent on the shape and/or design of the coupler 704.The one or more arc coupler modes of wave 706 can generate, influence, or impact one or more wave propagation modes of the guided wave 708 propagating along wire 702.It should be particularly noted however that the guided wave modes present in the guided wave 706 may be the same or different from the guided wave modes of the guided wave 708.In this fashion, one or more guided wave modes of the guided wave 706 may not be transferred to the guided wave 708, and further one or more guided wave modes of guided wave 708 may not have been present in guided wave 706.It should also be noted that the cut-off frequency of the arc coupler 704 for a particular guided wave mode may be different than the cutoff frequency of the wire 702 or other transmission medium for that same mode.", "For example, while the wire 702 or other transmission medium may be operated slightly above its cutoff frequency for a particular guided wave mode, the arc coupler 704 may be operated well above its cut-off frequency for that same mode for low loss, slightly below its cut-off frequency for that same mode to, for example, induce greater coupling and power transfer, or some other point in relation to the arc coupler's cutoff frequency for that mode.", "In an embodiment, the wave propagation modes on the wire 702 can be similar to the arc coupler modes since both waves 706 and 708 propagate about the outside of the arc coupler 704 and wire 702 respectively.", "In some embodiments, as the wave 706 couples to the wire 702, the modes can change form, or new modes can be created or generated, due to the coupling between the arc coupler 704 and the wire 702.For example, differences in size, material, and/or impedances of the arc coupler 704 and wire 702 may create additional modes not present in the arc coupler modes and/or suppress some of the arc coupler modes.", "The wave propagation modes can comprise the fundamental transverse electromagnetic mode (Quasi-TEM00), where only small electric and/or magnetic fields extend in the direction of propagation, and the electric and magnetic fields extend radially outwards while the guided wave propagates along the wire.", "This guided wave mode can be donut shaped, where few of the electromagnetic fields exist within the arc coupler 704 or wire 702.Waves 706 and 708 can comprise a fundamental TEM mode where the fields extend radially outwards, and also comprise other, non-fundamental (e.g., asymmetric, higher-level, etc.)", "modes.", "While particular wave propagation modes are discussed above, other wave propagation modes are likewise possible such as transverse electric (TE) and transverse magnetic (TM) modes, based on the frequencies employed, the design of the arc coupler 704, the dimensions and composition of the wire 702, as well as its surface characteristics, its insulation if present, the electromagnetic properties of the surrounding environment, etc.", "It should be noted that, depending on the frequency, the electrical and physical characteristics of the wire 702 and the particular wave propagation modes that are generated, guided wave 708 can travel along the conductive surface of an oxidized uninsulated wire, an unoxidized uninsulated wire, an insulated wire and/or along the insulating surface of an insulated wire.", "In an embodiment, a diameter of the arc coupler 704 is smaller than the diameter of the wire 702.For the millimeter-band wavelength being used, the arc coupler 704 supports a single waveguide mode that makes up wave 706.This single waveguide mode can change as it couples to the wire 702 as guided wave 708.If the arc coupler 704 were larger, more than one waveguide mode can be supported, but these additional waveguide modes may not couple to the wire 702 as efficiently, and higher coupling losses can result.", "However, in some alternative embodiments, the diameter of the arc coupler 704 can be equal to or larger than the diameter of the wire 702, for example, where higher coupling losses are desirable or when used in conjunction with other techniques to otherwise reduce coupling losses (e.g., impedance matching with tapering, etc.).", "In an embodiment, the wavelength of the waves 706 and 708 are comparable in size, or smaller than a circumference of the arc coupler 704 and the wire 702.In an example, if the wire 702 has a diameter of 0.5 cm, and a corresponding circumference of around 1.5 cm, the wavelength of the transmission is around 1.5 cm or less, corresponding to a frequency of 70 GHz or greater.", "In another embodiment, a suitable frequency of the transmission and the carrier-wave signal is in the range of 30-100 GHz, perhaps around 30-60 GHz, and around 38 GHz in one example.", "In an embodiment, when the circumference of the arc coupler 704 and wire 702 is comparable in size to, or greater, than a wavelength of the transmission, the waves 706 and 708 can exhibit multiple wave propagation modes including fundamental and/or non-fundamental (symmetric and/or asymmetric) modes that propagate over sufficient distances to support various communication systems described herein.", "The waves 706 and 708 can therefore comprise more than one type of electric and magnetic field configuration.", "In an embodiment, as the guided wave 708 propagates down the wire 702, the electrical and magnetic field configurations will remain the same from end to end of the wire 702.In other embodiments, as the guided wave 708 encounters interference (distortion or obstructions) or loses energy due to transmission losses or scattering, the electric and magnetic field configurations can change as the guided wave 708 propagates down wire 702.In an embodiment, the arc coupler 704 can be composed of nylon, Teflon, polyethylene, a polyamide, or other plastics.", "In other embodiments, other dielectric materials are possible.", "The wire surface of wire 702 can be metallic with either a bare metallic surface, or can be insulated using plastic, dielectric, insulator or other coating, jacket or sheathing.", "In an embodiment, a dielectric or otherwise non-conducting/insulated waveguide can be paired with either a bare/metallic wire or insulated wire.", "In other embodiments, a metallic and/or conductive waveguide can be paired with a bare/metallic wire or insulated wire.", "In an embodiment, an oxidation layer on the bare metallic surface of the wire 702 (e.g., resulting from exposure of the bare metallic surface to oxygen/air) can also provide insulating or dielectric properties similar to those provided by some insulators or sheathings.", "It is noted that the graphical representations of waves 706, 708 and 710 are presented merely to illustrate the principles that wave 706 induces or otherwise launches a guided wave 708 on a wire 702 that operates, for example, as a single wire transmission line.", "Wave 710 represents the portion of wave 706 that remains on the arc coupler 704 after the generation of guided wave 708.The actual electric and magnetic fields generated as a result of such wave propagation may vary depending on the frequencies employed, the particular wave propagation mode or modes, the design of the arc coupler 704, the dimensions and composition of the wire 702, as well as its surface characteristics, its optional insulation, the electromagnetic properties of the surrounding environment, etc.", "It is noted that arc coupler 704 can include a termination circuit or damper 714 at the end of the arc coupler 704 that can absorb leftover radiation or energy from wave 710.The termination circuit or damper 714 can prevent and/or minimize the leftover radiation or energy from wave 710 reflecting back toward transmitter circuit 712.In an embodiment, the termination circuit or damper 714 can include termination resistors, and/or other components that perform impedance matching to attenuate reflection.", "In some embodiments, if the coupling efficiencies are high enough, and/or wave 710 is sufficiently small, it may not be necessary to use a termination circuit or damper 714.For the sake of simplicity, these transmitter 712 and termination circuits or dampers 714 may not be depicted in the other figures, but in those embodiments, transmitter and termination circuits or dampers may possibly be used.", "Further, while a single arc coupler 704 is presented that generates a single guided wave 708, multiple arc couplers 704 placed at different points along the wire 702 and/or at different azimuthal orientations about the wire can be employed to generate and receive multiple guided waves 708 at the same or different frequencies, at the same or different phases, at the same or different wave propagation modes.", "FIG.", "8, a block diagram 800 illustrating an example, non-limiting embodiment of an arc coupler is shown.", "In the embodiment shown, at least a portion of the coupler 704 can be placed near a wire 702 or other transmission medium, (such as transmission medium 125), in order to facilitate coupling between the arc coupler 704 and the wire 702 or other transmission medium, to extract a portion of the guided wave 806 as a guided wave 808 as described herein.", "The arc coupler 704 can be placed such that a portion of the curved arc coupler 704 is tangential to, and parallel or substantially parallel to the wire 702.The portion of the arc coupler 704 that is parallel to the wire can be an apex of the curve, or any point where a tangent of the curve is parallel to the wire 702.When the arc coupler 704 is positioned or placed thusly, the wave 806 travelling along the wire 702 couples, at least in part, to the arc coupler 704, and propagates as guided wave 808 along the arc coupler 704 to a receiving device (not expressly shown).", "A portion of the wave 806 that does not couple to the arc coupler propagates as wave 810 along the wire 702 or other transmission medium.", "In an embodiment, the wave 806 can exhibit one or more wave propagation modes.", "The arc coupler modes can be dependent on the shape and/or design of the coupler 704.The one or more modes of guided wave 806 can generate, influence, or impact one or more guide-wave modes of the guided wave 808 propagating along the arc coupler 704.It should be particularly noted however that the guided wave modes present in the guided wave 806 may be the same or different from the guided wave modes of the guided wave 808.In this fashion, one or more guided wave modes of the guided wave 806 may not be transferred to the guided wave 808, and further one or more guided wave modes of guided wave 808 may not have been present in guided wave 806.Referring now to FIG.", "9A, a block diagram 900 illustrating an example, non-limiting embodiment of a stub coupler is shown.", "In particular a coupling device that includes stub coupler 904 is presented for use in a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1.The stub coupler 904 can be made of a dielectric material, or other low-loss insulator (e.g., Teflon, polyethylene and etc.", "), or made of a conducting (e.g., metallic, non-metallic, etc.)", "material, or any combination of the foregoing materials.", "As shown, the stub coupler 904 operates as a waveguide and has a wave 906 propagating as a guided wave about a waveguide surface of the stub coupler 904.In the embodiment shown, at least a portion of the stub coupler 904 can be placed near a wire 702 or other transmission medium, (such as transmission medium 125), in order to facilitate coupling between the stub coupler 904 and the wire 702 or other transmission medium, as described herein to launch the guided wave 908 on the wire.", "In an embodiment, the stub coupler 904 is curved, and an end of the stub coupler 904 can be tied, fastened, or otherwise mechanically coupled to a wire 702.When the end of the stub coupler 904 is fastened to the wire 702, the end of the stub coupler 904 is parallel or substantially parallel to the wire 702.Alternatively, another portion of the dielectric waveguide beyond an end can be fastened or coupled to wire 702 such that the fastened or coupled portion is parallel or substantially parallel to the wire 702.The fastener 910 can be a nylon cable tie or other type of non-conducting/dielectric material that is either separate from the stub coupler 904 or constructed as an integrated component of the stub coupler 904.The stub coupler 904 can be adjacent to the wire 702 without surrounding the wire 702.Like the arc coupler 704 described in conjunction with FIG.", "7, when the stub coupler 904 is placed with the end parallel to the wire 702, the guided wave 906 travelling along the stub coupler 904 couples to the wire 702, and propagates as guided wave 908 about the wire surface of the wire 702.In an example embodiment, the guided wave 908 can be characterized as a surface wave or other electromagnetic wave.", "It is noted that the graphical representations of waves 906 and 908 are presented merely to illustrate the principles that wave 906 induces or otherwise launches a guided wave 908 on a wire 702 that operates, for example, as a single wire transmission line.", "The actual electric and magnetic fields generated as a result of such wave propagation may vary depending on one or more of the shape and/or design of the coupler, the relative position of the dielectric waveguide to the wire, the frequencies employed, the design of the stub coupler 904, the dimensions and composition of the wire 702, as well as its surface characteristics, its optional insulation, the electromagnetic properties of the surrounding environment, etc.", "In an embodiment, an end of stub coupler 904 can taper towards the wire 702 in order to increase coupling efficiencies.", "Indeed, the tapering of the end of the stub coupler 904 can provide impedance matching to the wire 702 and reduce reflections, according to an example embodiment of the subject disclosure.", "For example, an end of the stub coupler 904 can be gradually tapered in order to obtain a desired level of coupling between waves 906 and 908 as illustrated in FIG.", "9A.", "In an embodiment, the fastener 910 can be placed such that there is a short length of the stub coupler 904 between the fastener 910 and an end of the stub coupler 904.Maximum coupling efficiencies are realized in this embodiment when the length of the end of the stub coupler 904 that is beyond the fastener 910 is at least several wavelengths long for whatever frequency is being transmitted.", "Turning now to FIG.", "9B, a diagram 950 illustrating an example, non-limiting embodiment of an electromagnetic distribution in accordance with various aspects described herein is shown.", "In particular, an electromagnetic distribution is presented in two dimensions for a transmission device that includes coupler 952, shown in an example stub coupler constructed of a dielectric material.", "The coupler 952 couples an electromagnetic wave for propagation as a guided wave along an outer surface of a wire 702 or other transmission medium.", "The coupler 952 guides the electromagnetic wave to a junction at x0 via a symmetrical guided wave mode.", "While some of the energy of the electromagnetic wave that propagates along the coupler 952 is outside of the coupler 952, the majority of the energy of this electromagnetic wave is contained within the coupler 952.The junction at x0 couples the electromagnetic wave to the wire 702 or other transmission medium at an azimuthal angle corresponding to the bottom of the transmission medium.", "This coupling induces an electromagnetic wave that is guided to propagate along the outer surface of the wire 702 or other transmission medium via at least one guided wave mode in direction 956.The majority of the energy of the guided electromagnetic wave is outside or, but in close proximity to the outer surface of the wire 702 or other transmission medium.", "In the example shown, the junction at x0 forms an electromagnetic wave that propagates via both a symmetrical mode and at least one asymmetrical surface mode, such as the first order mode presented in conjunction with FIG.", "3, that skims the surface of the wire 702 or other transmission medium.", "It is noted that the graphical representations of guided waves are presented merely to illustrate an example of guided wave coupling and propagation.", "The actual electric and magnetic fields generated as a result of such wave propagation may vary depending on the frequencies employed, the design and/or configuration of the coupler 952, the dimensions and composition of the wire 702 or other transmission medium, as well as its surface characteristics, its insulation if present, the electromagnetic properties of the surrounding environment, etc.", "Turning now to FIG.", "10A, illustrated is a block diagram 1000 of an example, non-limiting embodiment of a coupler and transceiver system in accordance with various aspects described herein.", "The system is an example of transmission device 101 or 102.In particular, the communication interface 1008 is an example of communications interface 205, the stub coupler 1002 is an example of coupler 220, and the transmitter/receiver device 1006, diplexer 1016, power amplifier 1014, low noise amplifier 1018, frequency mixers 1010 and 1020 and local oscillator 1012 collectively form an example of transceiver 210.In operation, the transmitter/receiver device 1006 launches and receives waves (e.g., guided wave 1004 onto stub coupler 1002).", "The guided waves 1004 can be used to transport signals received from and sent to a host device, base station, mobile devices, a building or other device by way of a communications interface 1008.The communications interface 1008 can be an integral part of system 1000.Alternatively, the communications interface 1008 can be tethered to system 1000.The communications interface 1008 can comprise a wireless interface for interfacing to the host device, base station, mobile devices, a building or other device utilizing any of various wireless signaling protocols (e.g., LTE, WiFi, WiMAX, IEEE 802.xx, etc.)", "including an infrared protocol such as an infrared data association (IrDA) protocol or other line of sight optical protocol.", "The communications interface 1008 can also comprise a wired interface such as a fiber optic line, coaxial cable, twisted pair, category 5 (CAT-5) cable or other suitable wired or optical mediums for communicating with the host device, base station, mobile devices, a building or other device via a protocol such as an Ethernet protocol, universal serial bus (USB) protocol, a data over cable service interface specification (DOCSIS) protocol, a digital subscriber line (DSL) protocol, a Firewire (IEEE 1394) protocol, or other wired or optical protocol.", "For embodiments where system 1000 functions as a repeater, the communications interface 1008 may not be necessary.", "The output signals (e.g., Tx) of the communications interface 1008 can be combined with a carrier wave (e.g., millimeter-wave carrier wave) generated by a local oscillator 1012 at frequency mixer 1010.Frequency mixer 1010 can use heterodyning techniques or other frequency shifting techniques to frequency shift the output signals from communications interface 1008.For example, signals sent to and from the communications interface 1008 can be modulated signals such as orthogonal frequency division multiplexed (OFDM) signals formatted in accordance with a Long-Term Evolution (LTE) wireless protocol or other wireless 3G, 4G, 5G or higher voice and data protocol, a Zigbee, WIMAX, UltraWideband or IEEE 802.11 wireless protocol; a wired protocol such as an Ethernet protocol, universal serial bus (USB) protocol, a data over cable service interface specification (DOCSIS) protocol, a digital subscriber line (DSL) protocol, a Firewire (IEEE 1394) protocol or other wired or wireless protocol.", "In an example embodiment, this frequency conversion can be done in the analog domain, and as a result, the frequency shifting can be done without regard to the type of communications protocol used by a base station, mobile devices, or in-building devices.", "As new communications technologies are developed, the communications interface 1008 can be upgraded (e.g., updated with software, firmware, and/or hardware) or replaced and the frequency shifting and transmission apparatus can remain, simplifying upgrades.", "The carrier wave can then be sent to a power amplifier (“PA”) 1014 and can be transmitted via the transmitter receiver device 1006 via the diplexer 1016.Signals received from the transmitter/receiver device 1006 that are directed towards the communications interface 1008 can be separated from other signals via diplexer 1016.The received signal can then be sent to low noise amplifier (“LNA”) 1018 for amplification.", "A frequency mixer 1020, with help from local oscillator 1012 can downshift the received signal (which is in the millimeter-wave band or around 38 GHz in some embodiments) to the native frequency.", "The communications interface 1008 can then receive the transmission at an input port (Rx).", "In an embodiment, transmitter/receiver device 1006 can include a cylindrical or non-cylindrical metal (which, for example, can be hollow in an embodiment, but not necessarily drawn to scale) or other conducting or non-conducting waveguide and an end of the stub coupler 1002 can be placed in or in proximity to the waveguide or the transmitter/receiver device 1006 such that when the transmitter/receiver device 1006 generates a transmission, the guided wave couples to stub coupler 1002 and propagates as a guided wave 1004 about the waveguide surface of the stub coupler 1002.In some embodiments, the guided wave 1004 can propagate in part on the outer surface of the stub coupler 1002 and in part inside the stub coupler 1002.In other embodiments, the guided wave 1004 can propagate substantially or completely on the outer surface of the stub coupler 1002.In yet other embodiments, the guided wave 1004 can propagate substantially or completely inside the stub coupler 1002.In this latter embodiment, the guided wave 1004 can radiate at an end of the stub coupler 1002 (such as the tapered end shown in FIG.", "4) for coupling to a transmission medium such as a wire 702 of FIG.", "7.Similarly, if guided wave 1004 is incoming (coupled to the stub coupler 1002 from a wire 702), guided wave 1004 then enters the transmitter/receiver device 1006 and couples to the cylindrical waveguide or conducting waveguide.", "While transmitter/receiver device 1006 is shown to include a separate waveguide—an antenna, cavity resonator, klystron, magnetron, travelling wave tube, or other radiating element can be employed to induce a guided wave on the coupler 1002, with or without the separate waveguide.", "In an embodiment, stub coupler 1002 can be wholly constructed of a dielectric material (or another suitable insulating material), without any metallic or otherwise conducting materials therein.", "Stub coupler 1002 can be composed of nylon, Teflon, polyethylene, a polyamide, other plastics, or other materials that are non-conducting and suitable for facilitating transmission of electromagnetic waves at least in part on an outer surface of such materials.", "In another embodiment, stub coupler 1002 can include a core that is conducting/metallic, and have an exterior dielectric surface.", "Similarly, a transmission medium that couples to the stub coupler 1002 for propagating electromagnetic waves induced by the stub coupler 1002 or for supplying electromagnetic waves to the stub coupler 1002 can, in addition to being a bare or insulated wire, be wholly constructed of a dielectric material (or another suitable insulating material), without any metallic or otherwise conducting materials therein.", "It is noted that although FIG.", "10A shows that the opening of transmitter receiver device 1006 is much wider than the stub coupler 1002, this is not to scale, and that in other embodiments the width of the stub coupler 1002 is comparable or slightly smaller than the opening of the hollow waveguide.", "It is also not shown, but in an embodiment, an end of the coupler 1002 that is inserted into the transmitter/receiver device 1006 tapers down in order to reduce reflection and increase coupling efficiencies.", "Before coupling to the stub coupler 1002, the one or more waveguide modes of the guided wave generated by the transmitter/receiver device 1006 can couple to the stub coupler 1002 to induce one or more wave propagation modes of the guided wave 1004.The wave propagation modes of the guided wave 1004 can be different than the hollow metal waveguide modes due to the different characteristics of the hollow metal waveguide and the dielectric waveguide.", "For instance, wave propagation modes of the guided wave 1004 can comprise the fundamental transverse electromagnetic mode (Quasi-TEM00), where only small electrical and/or magnetic fields extend in the direction of propagation, and the electric and magnetic fields extend radially outwards from the stub coupler 1002 while the guided waves propagate along the stub coupler 1002.The fundamental transverse electromagnetic mode wave propagation mode may or may not exist inside a waveguide that is hollow.", "Therefore, the hollow metal waveguide modes that are used by transmitter/receiver device 1006 are waveguide modes that can couple effectively and efficiently to wave propagation modes of stub coupler 1002.It will be appreciated that other constructs or combinations of the transmitter/receiver device 1006 and stub coupler 1002 are possible.", "For example, a stub coupler 1002′ can be placed tangentially or in parallel (with or without a gap) with respect to an outer surface of the hollow metal waveguide of the transmitter/receiver device 1006′ (corresponding circuitry not shown) as depicted by reference 1000′ of FIG.", "10B.", "In another embodiment, not shown by reference 1000′, the stub coupler 1002′ can be placed inside the hollow metal waveguide of the transmitter/receiver device 1006′ without an axis of the stub coupler 1002′ being coaxially aligned with an axis of the hollow metal waveguide of the transmitter/receiver device 1006′.", "In either of these embodiments, the guided wave generated by the transmitter/receiver device 1006′ can couple to a surface of the stub coupler 1002′ to induce one or more wave propagation modes of the guided wave 1004′ on the stub coupler 1002′ including a fundamental mode (e.g., a symmetric mode) and/or a non-fundamental mode (e.g., asymmetric mode).", "In one embodiment, the guided wave 1004′ can propagate in part on the outer surface of the stub coupler 1002′ and in part inside the stub coupler 1002′.", "In another embodiment, the guided wave 1004′ can propagate substantially or completely on the outer surface of the stub coupler 1002′.", "In yet other embodiments, the guided wave 1004′ can propagate substantially or completely inside the stub coupler 1002′.", "In this latter embodiment, the guided wave 1004′ can radiate at an end of the stub coupler 1002′ (such as the tapered end shown in FIG.", "9) for coupling to a transmission medium such as a wire 702 of FIG.", "9.It will be further appreciated that other constructs the transmitter/receiver device 1006 are possible.", "For example, a hollow metal waveguide of a transmitter/receiver device 1006″ (corresponding circuitry not shown), depicted in FIG.", "10B as reference 1000″, can be placed tangentially or in parallel (with or without a gap) with respect to an outer surface of a transmission medium such as the wire 702 of FIG.", "4 without the use of the stub coupler 1002.In this embodiment, the guided wave generated by the transmitter/receiver device 1006″ can couple to a surface of the wire 702 to induce one or more wave propagation modes of a guided wave 908 on the wire 702 including a fundamental mode (e.g., a symmetric mode) and/or a non-fundamental mode (e.g., asymmetric mode).", "In another embodiment, the wire 702 can be positioned inside a hollow metal waveguide of a transmitter/receiver device 1006′″ (corresponding circuitry not shown) so that an axis of the wire 702 is coaxially (or not coaxially) aligned with an axis of the hollow metal waveguide without the use of the stub coupler 1002—see FIGS.", "10B reference 1000′″.", "In this embodiment, the guided wave generated by the transmitter/receiver device 1006′″ can couple to a surface of the wire 702 to induce one or more wave propagation modes of a guided wave 908 on the wire including a fundamental mode (e.g., a symmetric mode) and/or a non-fundamental mode (e.g., asymmetric mode).", "In the embodiments of 1000″ and 1000′″, for a wire 702 having an insulated outer surface, the guided wave 908 can propagate in part on the outer surface of the insulator and in part inside the insulator.", "In embodiments, the guided wave 908 can propagate substantially or completely on the outer surface of the insulator, or substantially or completely inside the insulator.", "In the embodiments of 1000″ and 1000′″, for a wire 702 that is a bare conductor, the guided wave 908 can propagate in part on the outer surface of the conductor and in part inside the conductor.", "In another embodiment, the guided wave 908 can propagate substantially or completely on the outer surface of the conductor.", "Referring now to FIG.", "11, a block diagram 1100 illustrating an example, non-limiting embodiment of a dual stub coupler is shown.", "In particular, a dual coupler design is presented for use in a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1.In an embodiment, two or more couplers (such as the stub couplers 1104 and 1106) can be positioned around a wire 1102 in order to receive guided wave 1108.In an embodiment, one coupler is enough to receive the guided wave 1108.In that case, guided wave 1108 couples to coupler 1104 and propagates as guided wave 1110.If the field structure of the guided wave 1108 oscillates or undulates around the wire 1102 due to the particular guided wave mode(s) or various outside factors, then coupler 1106 can be placed such that guided wave 1108 couples to coupler 1106.In some embodiments, four or more couplers can be placed around a portion of the wire 1102, e.g., at 90 degrees or another spacing with respect to each other, in order to receive guided waves that may oscillate or rotate around the wire 1102, that have been induced at different azimuthal orientations or that have non-fundamental or higher order modes that, for example, have lobes and/or nulls or other asymmetries that are orientation dependent.", "However, it will be appreciated that there may be less than or more than four couplers placed around a portion of the wire 1102 without departing from example embodiments.", "It should be noted that while couplers 1106 and 1104 are illustrated as stub couplers, any other of the coupler designs described herein including arc couplers, antenna or horn couplers, magnetic couplers, etc., could likewise be used.", "It will also be appreciated that while some example embodiments have presented a plurality of couplers around at least a portion of a wire 1102, this plurality of couplers can also be considered as part of a single coupler system having multiple coupler subcomponents.", "For example, two or more couplers can be manufactured as single system that can be installed around a wire in a single installation such that the couplers are either pre-positioned or adjustable relative to each other (either manually or automatically with a controllable mechanism such as a motor or other actuator) in accordance with the single system.", "Receivers coupled to couplers 1106 and 1104 can use diversity combining to combine signals received from both couplers 1106 and 1104 in order to maximize the signal quality.", "In other embodiments, if one or the other of the couplers 1104 and 1106 receive a transmission that is above a predetermined threshold, receivers can use selection diversity when deciding which signal to use.", "Further, while reception by a plurality of couplers 1106 and 1104 is illustrated, transmission by couplers 1106 and 1104 in the same configuration can likewise take place.", "In particular, a wide range of multi-input multi-output (MIMO) transmission and reception techniques can be employed for transmissions where a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1 includes multiple transceivers and multiple couplers.", "It is noted that the graphical representations of waves 1108 and 1110 are presented merely to illustrate the principles that guided wave 1108 induces or otherwise launches a wave 1110 on a coupler 1104.The actual electric and magnetic fields generated as a result of such wave propagation may vary depending on the frequencies employed, the design of the coupler 1104, the dimensions and composition of the wire 1102, as well as its surface characteristics, its insulation if any, the electromagnetic properties of the surrounding environment, etc.", "Referring now to FIG.", "12, a block diagram 1200 illustrating an example, non-limiting embodiment of a repeater system is shown.", "In particular, a repeater device 1210 is presented for use in a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1.In this system, two couplers 1204 and 1214 can be placed near a wire 1202 or other transmission medium such that guided waves 1205 propagating along the wire 1202 are extracted by coupler 1204 as wave 1206 (e.g.", "as a guided wave), and then are boosted or repeated by repeater device 1210 and launched as a wave 1216 (e.g.", "as a guided wave) onto coupler 1214.The wave 1216 can then be launched on the wire 1202 and continue to propagate along the wire 1202 as a guided wave 1217.In an embodiment, the repeater device 1210 can receive at least a portion of the power utilized for boosting or repeating through magnetic coupling with the wire 1202, for example, when the wire 1202 is a power line or otherwise contains a power-carrying conductor.", "It should be noted that while couplers 1204 and 1214 are illustrated as stub couplers, any other of the coupler designs described herein including arc couplers, antenna or horn couplers, magnetic couplers, or the like, could likewise be used.", "In some embodiments, repeater device 1210 can repeat the transmission associated with wave 1206, and in other embodiments, repeater device 1210 can include a communications interface 205 that extracts data or other signals from the wave 1206 for supplying such data or signals to another network and/or one or more other devices as communication signals 110 or 112 and/or receiving communication signals 110 or 112 from another network and/or one or more other devices and launch guided wave 1216 having embedded therein the received communication signals 110 or 112.In a repeater configuration, receiver waveguide 1208 can receive the wave 1206 from the coupler 1204 and transmitter waveguide 1212 can launch guided wave 1216 onto coupler 1214 as guided wave 1217.Between receiver waveguide 1208 and transmitter waveguide 1212, the signal embedded in guided wave 1206 and/or the guided wave 1216 itself can be amplified to correct for signal loss and other inefficiencies associated with guided wave communications or the signal can be received and processed to extract the data contained therein and regenerated for transmission.", "In an embodiment, the receiver waveguide 1208 can be configured to extract data from the signal, process the data to correct for data errors utilizing for example error correcting codes, and regenerate an updated signal with the corrected data.", "The transmitter waveguide 1212 can then transmit guided wave 1216 with the updated signal embedded therein.", "In an embodiment, a signal embedded in guided wave 1206 can be extracted from the transmission and processed for communication with another network and/or one or more other devices via communications interface 205 as communication signals 110 or 112.Similarly, communication signals 110 or 112 received by the communications interface 205 can be inserted into a transmission of guided wave 1216 that is generated and launched onto coupler 1214 by transmitter waveguide 1212.It is noted that although FIG.", "12 shows guided wave transmissions 1206 and 1216 entering from the left and exiting to the right respectively, this is merely a simplification and is not intended to be limiting.", "In other embodiments, receiver waveguide 1208 and transmitter waveguide 1212 can also function as transmitters and receivers respectively, allowing the repeater device 1210 to be bi-directional.", "In an embodiment, repeater device 1210 can be placed at locations where there are discontinuities or obstacles on the wire 1202 or other transmission medium.", "In the case where the wire 1202 is a power line, these obstacles can include transformers, connections, utility poles, and other such power line devices.", "The repeater device 1210 can help the guided (e.g., surface) waves jump over these obstacles on the line and boost the transmission power at the same time.", "In other embodiments, a coupler can be used to jump over the obstacle without the use of a repeater device.", "In that embodiment, both ends of the coupler can be tied or fastened to the wire, thus providing a path for the guided wave to travel without being blocked by the obstacle.", "Turning now to FIG.", "13, illustrated is a block diagram 1300 of an example, non-limiting embodiment of a bidirectional repeater in accordance with various aspects described herein.", "In particular, a bidirectional repeater device 1306 is presented for use in a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1.It should be noted that while the couplers are illustrated as stub couplers, any other of the coupler designs described herein including arc couplers, antenna or horn couplers, magnetic couplers, or the like, could likewise be used.", "The bidirectional repeater 1306 can employ diversity paths in the case of when two or more wires or other transmission media are present.", "Since guided wave transmissions have different transmission efficiencies and coupling efficiencies for transmission medium of different types such as insulated wires, un-insulated wires or other types of transmission media and further, if exposed to the elements, can be affected by weather, and other atmospheric conditions, it can be advantageous to selectively transmit on different transmission media at certain times.", "In various embodiments, the various transmission media can be designated as a primary, secondary, tertiary, etc.", "whether or not such designation indicates a preference of one transmission medium over another.", "In the embodiment shown, the transmission media include an insulated or uninsulated wire 1302 and an insulated or uninsulated wire 1304 (referred to herein as wires 1302 and 1304, respectively).", "The repeater device 1306 uses a receiver coupler 1308 to receive a guided wave traveling along wire 1302 and repeats the transmission using transmitter waveguide 1310 as a guided wave along wire 1304.In other embodiments, repeater device 1306 can switch from the wire 1304 to the wire 1302, or can repeat the transmissions along the same paths.", "Repeater device 1306 can include sensors, or be in communication with sensors (or a network management system 1601 depicted in FIG.", "16A) that indicate conditions that can affect the transmission.", "Based on the feedback received from the sensors, the repeater device 1306 can make the determination about whether to keep the transmission along the same wire, or transfer the transmission to the other wire.", "Turning now to FIG.", "14, illustrated is a block diagram 1400 illustrating an example, non-limiting embodiment of a bidirectional repeater system.", "In particular, a bidirectional repeater system is presented for use in a transmission device, such as transmission device 101 or 102 presented in conjunction with FIG.", "1.The bidirectional repeater system includes waveguide coupling devices 1402 and 1404 that receive and transmit transmissions from other coupling devices located in a distributed antenna system or backhaul system.", "In various embodiments, waveguide coupling device 1402 can receive a transmission from another waveguide coupling device, wherein the transmission has a plurality of subcarriers.", "Diplexer 1406 can separate the transmission from other transmissions, and direct the transmission to low-noise amplifier (“LNA”) 1408.A frequency mixer 1428, with help from a local oscillator 1412, can downshift the transmission (which is in the millimeter-wave band or around 38 GHz in some embodiments) to a lower frequency, such as a cellular band (˜1.9 GHz) for a distributed antenna system, a native frequency, or other frequency for a backhaul system.", "An extractor (or demultiplexer) 1432 can extract the signal on a subcarrier and direct the signal to an output component 1422 for optional amplification, buffering or isolation by power amplifier 1424 for coupling to communications interface 205.The communications interface 205 can further process the signals received from the power amplifier 1424 or otherwise transmit such signals over a wireless or wired interface to other devices such as a base station, mobile devices, a building, etc.", "For the signals that are not being extracted at this location, extractor 1432 can redirect them to another frequency mixer 1436, where the signals are used to modulate a carrier wave generated by local oscillator 1414.The carrier wave, with its subcarriers, is directed to a power amplifier (“PA”) 1416 and is retransmitted by waveguide coupling device 1404 to another system, via diplexer 1420.An LNA 1426 can be used to amplify, buffer or isolate signals that are received by the communication interface 205 and then send the signal to a multiplexer 1434 which merges the signal with signals that have been received from waveguide coupling device 1404.The signals received from coupling device 1404 have been split by diplexer 1420, and then passed through LNA 1418, and downshifted in frequency by frequency mixer 1438.When the signals are combined by multiplexer 1434, they are upshifted in frequency by frequency mixer 1430, and then boosted by PA 1410, and transmitted to another system by waveguide coupling device 1402.In an embodiment bidirectional repeater system can be merely a repeater without the output device 1422.In this embodiment, the multiplexer 1434 would not be utilized and signals from LNA 1418 would be directed to mixer 1430 as previously described.", "It will be appreciated that in some embodiments, the bidirectional repeater system could also be implemented using two distinct and separate unidirectional repeaters.", "In an alternative embodiment, a bidirectional repeater system could also be a booster or otherwise perform retransmissions without downshifting and upshifting.", "Indeed in example embodiment, the retransmissions can be based upon receiving a signal or guided wave and performing some signal or guided wave processing or reshaping, filtering, and/or amplification, prior to retransmission of the signal or guided wave.", "Referring now to FIG.", "15, a block diagram 1500 illustrating an example, non-limiting embodiment of a guided wave communications system is shown.", "This diagram depicts an exemplary environment in which a guided wave communication system, such as the guided wave communication system presented in conjunction with FIG.", "1, can be used.", "To provide network connectivity to additional base station devices, a backhaul network that links the communication cells (e.g., macrocells and macrocells) to network devices of a core network correspondingly expands.", "Similarly, to provide network connectivity to a distributed antenna system, an extended communication system that links base station devices and their distributed antennas is desirable.", "A guided wave communication system 1500 such as shown in FIG.", "15 can be provided to enable alternative, increased or additional network connectivity and a waveguide coupling system can be provided to transmit and/or receive guided wave (e.g., surface wave) communications on a transmission medium such as a wire that operates as a single-wire transmission line (e.g., a utility line), and that can be used as a waveguide and/or that otherwise operates to guide the transmission of an electromagnetic wave.", "The guided wave communication system 1500 can comprise a first instance of a distribution system 1550 that includes one or more base station devices (e.g., base station device 1504) that are communicably coupled to a central office 1501 and/or a macrocell site 1502.Base station device 1504 can be connected by a wired (e.g., fiber and/or cable), or by a wireless (e.g., microwave wireless) connection to the macrocell site 1502 and the central office 1501.A second instance of the distribution system 1560 can be used to provide wireless voice and data services to mobile device 1522 and to residential and/or commercial establishments 1542 (herein referred to as establishments 1542).", "System 1500 can have additional instances of the distribution systems 1550 and 1560 for providing voice and/or data services to mobile devices 1522-1524 and establishments 1542 as shown in FIG.", "15.Macrocells such as macrocell site 1502 can have dedicated connections to a mobile network and base station device 1504 or can share and/or otherwise use another connection.", "Central office 1501 can be used to distribute media content and/or provide internet service provider (ISP) services to mobile devices 1522-1524 and establishments 1542.The central office 1501 can receive media content from a constellation of satellites 1530 (one of which is shown in FIG.", "15) or other sources of content, and distribute such content to mobile devices 1522-1524 and establishments 1542 via the first and second instances of the distribution system 1550 and 1560.The central office 1501 can also be communicatively coupled to the Internet 1503 for providing internet data services to mobile devices 1522-1524 and establishments 1542.Base station device 1504 can be mounted on, or attached to, utility pole 1516.In other embodiments, base station device 1504 can be near transformers and/or other locations situated nearby a power line.", "Base station device 1504 can facilitate connectivity to a mobile network for mobile devices 1522 and 1524.Antennas 1512 and 1514, mounted on or near utility poles 1518 and 1520, respectively, can receive signals from base station device 1504 and transmit those signals to mobile devices 1522 and 1524 over a much wider area than if the antennas 1512 and 1514 were located at or near base station device 1504.It is noted that FIG.", "15 displays three utility poles, in each instance of the distribution systems 1550 and 1560, with one base station device, for purposes of simplicity.", "In other embodiments, utility pole 1516 can have more base station devices, and more utility poles with distributed antennas and/or tethered connections to establishments 1542.A transmission device 1506, such as transmission device 101 or 102 presented in conjunction with FIG.", "1, can transmit a signal from base station device 1504 to antennas 1512 and 1514 via utility or power line(s) that connect the utility poles 1516, 1518, and 1520.To transmit the signal, radio source and/or transmission device 1506 upconverts the signal (e.g., via frequency mixing) from base station device 1504 or otherwise converts the signal from the base station device 1504 to a microwave band signal and the transmission device 1506 launches a microwave band wave that propagates as a guided wave traveling along the utility line or other wire as described in previous embodiments.", "At utility pole 1518, another transmission device 1508 receives the guided wave (and optionally can amplify it as needed or desired or operate as a repeater to receive it and regenerate it) and sends it forward as a guided wave on the utility line or other wire.", "The transmission device 1508 can also extract a signal from the microwave band guided wave and shift it down in frequency or otherwise convert it to its original cellular band frequency (e.g., 1.9 GHz or other defined cellular frequency) or another cellular (or non-cellular) band frequency.", "An antenna 1512 can wireless transmit the downshifted signal to mobile device 1522.The process can be repeated by transmission device 1510, antenna 1514 and mobile device 1524, as necessary or desirable.", "Transmissions from mobile devices 1522 and 1524 can also be received by antennas 1512 and 1514 respectively.", "The transmission devices 1508 and 1510 can upshift or otherwise convert the cellular band signals to microwave band and transmit the signals as guided wave (e.g., surface wave or other electromagnetic wave) transmissions over the power line(s) to base station device 1504.Media content received by the central office 1501 can be supplied to the second instance of the distribution system 1560 via the base station device 1504 for distribution to mobile devices 1522 and establishments 1542.The transmission device 1510 can be tethered to the establishments 1542 by one or more wired connections or a wireless interface.", "The one or more wired connections may include without limitation, a power line, a coaxial cable, a fiber cable, a twisted pair cable, a guided wave transmission medium or other suitable wired mediums for distribution of media content and/or for providing internet services.", "In an example embodiment, the wired connections from the transmission device 1510 can be communicatively coupled to one or more very high bit rate digital subscriber line (VDSL) modems located at one or more corresponding service area interfaces (SAIs—not shown) or pedestals, each SAI or pedestal providing services to a portion of the establishments 1542.The VDSL modems can be used to selectively distribute media content and/or provide internet services to gateways (not shown) located in the establishments 1542.The SAIs or pedestals can also be communicatively coupled to the establishments 1542 over a wired medium such as a power line, a coaxial cable, a fiber cable, a twisted pair cable, a guided wave transmission medium or other suitable wired mediums.", "In other example embodiments, the transmission device 1510 can be communicatively coupled directly to establishments 1542 without intermediate interfaces such as the SAIs or pedestals.", "In another example embodiment, system 1500 can employ diversity paths, where two or more utility lines or other wires are strung between the utility poles 1516, 1518, and 1520 (e.g., for example, two or more wires between poles 1516 and 1520) and redundant transmissions from base station/macrocell site 1502 are transmitted as guided waves down the surface of the utility lines or other wires.", "The utility lines or other wires can be either insulated or uninsulated, and depending on the environmental conditions that cause transmission losses, the coupling devices can selectively receive signals from the insulated or uninsulated utility lines or other wires.", "The selection can be based on measurements of the signal-to-noise ratio of the wires, or based on determined weather/environmental conditions (e.g., moisture detectors, weather forecasts, etc.).", "The use of diversity paths with system 1500 can enable alternate routing capabilities, load balancing, increased load handling, concurrent bi-directional or synchronous communications, spread spectrum communications, etc.", "It is noted that the use of the transmission devices 1506, 1508, and 1510 in FIG.", "15 are by way of example only, and that in other embodiments, other uses are possible.", "For instance, transmission devices can be used in a backhaul communication system, providing network connectivity to base station devices.", "Transmission devices 1506, 1508, and 1510 can be used in many circumstances where it is desirable to transmit guided wave communications over a wire, whether insulated or not insulated.", "Transmission devices 1506, 1508, and 1510 are improvements over other coupling devices due to no contact or limited physical and/or electrical contact with the wires that may carry high voltages.", "The transmission device can be located away from the wire (e.g., spaced apart from the wire) and/or located on the wire so long as it is not electrically in contact with the wire, as the dielectric acts as an insulator, allowing for cheap, easy, and/or less complex installation.", "However, as previously noted conducting or non-dielectric couplers can be employed, for example in configurations where the wires correspond to a telephone network, cable television network, broadband data service, fiber optic communications system or other network employing low voltages or having insulated transmission lines.", "It is further noted, that while base station device 1504 and macrocell site 1502 are illustrated in an embodiment, other network configurations are likewise possible.", "For example, devices such as access points or other wireless gateways can be employed in a similar fashion to extend the reach of other networks such as a wireless local area network, a wireless personal area network or other wireless network that operates in accordance with a communication protocol such as a 802.11 protocol, WIMAX protocol, UltraWideband protocol, Bluetooth protocol, Zigbee protocol or other wireless protocol.", "Referring now to FIGS.", "16A & 16B, block diagrams illustrating an example, non-limiting embodiment of a system for managing a power grid communication system are shown.", "Considering FIG.", "16A, a waveguide system 1602 is presented for use in a guided wave communications system, such as the system presented in conjunction with FIG.", "15.The waveguide system 1602 can comprise sensors 1604, a power management system 1605, a transmission device 101 or 102 that includes at least one communication interface 205, transceiver 210 and coupler 220.The waveguide system 1602 can be coupled to a power line 1610 for facilitating guided wave communications in accordance with embodiments described in the subject disclosure.", "In an example embodiment, the transmission device 101 or 102 includes coupler 220 for inducing electromagnetic waves on a surface of the power line 1610 that longitudinally propagate along the surface of the power line 1610 as described in the subject disclosure.", "The transmission device 101 or 102 can also serve as a repeater for retransmitting electromagnetic waves on the same power line 1610 or for routing electromagnetic waves between power lines 1610 as shown in FIGS.", "12-13.The transmission device 101 or 102 includes transceiver 210 configured to, for example, up-convert a signal operating at an original frequency range to electromagnetic waves operating at, exhibiting, or associated with a carrier frequency that propagate along a coupler to induce corresponding guided electromagnetic waves that propagate along a surface of the power line 1610.A carrier frequency can be represented by a center frequency having upper and lower cutoff frequencies that define the bandwidth of the electromagnetic waves.", "The power line 1610 can be a wire (e.g., single stranded or multi-stranded) having a conducting surface or insulated surface.", "The transceiver 210 can also receive signals from the coupler 220 and down-convert the electromagnetic waves operating at a carrier frequency to signals at their original frequency.", "Signals received by the communications interface 205 of transmission device 101 or 102 for up-conversion can include without limitation signals supplied by a central office 1611 over a wired or wireless interface of the communications interface 205, a base station 1614 over a wired or wireless interface of the communications interface 205, wireless signals transmitted by mobile devices 1620 to the base station 1614 for delivery over the wired or wireless interface of the communications interface 205, signals supplied by in-building communication devices 1618 over the wired or wireless interface of the communications interface 205, and/or wireless signals supplied to the communications interface 205 by mobile devices 1612 roaming in a wireless communication range of the communications interface 205.In embodiments where the waveguide system 1602 functions as a repeater, such as shown in FIGS.", "12-13, the communications interface 205 may or may not be included in the waveguide system 1602.The electromagnetic waves propagating along the surface of the power line 1610 can be modulated and formatted to include packets or frames of data that include a data payload and further include networking information (such as header information for identifying one or more destination waveguide systems 1602).", "The networking information may be provided by the waveguide system 1602 or an originating device such as the central office 1611, the base station 1614, mobile devices 1620, or in-building devices 1618, or a combination thereof.", "Additionally, the modulated electromagnetic waves can include error correction data for mitigating signal disturbances.", "The networking information and error correction data can be used by a destination waveguide system 1602 for detecting transmissions directed to it, and for down-converting and processing with error correction data transmissions that include voice and/or data signals directed to recipient communication devices communicatively coupled to the destination waveguide system 1602.Referring now to the sensors 1604 of the waveguide system 1602, the sensors 1604 can comprise one or more of a temperature sensor 1604a, a disturbance detection sensor 1604b, a loss of energy sensor 1604c, a noise sensor 1604d, a vibration sensor 1604e, an environmental (e.g., weather) sensor 1604f, and/or an image sensor 1604g.", "The temperature sensor 1604a can be used to measure ambient temperature, a temperature of the transmission device 101 or 102, a temperature of the power line 1610, temperature differentials (e.g., compared to a setpoint or baseline, between transmission device 101 or 102 and 1610, etc.", "), or any combination thereof.", "In one embodiment, temperature metrics can be collected and reported periodically to a network management system 1601 by way of the base station 1614.The disturbance detection sensor 1604b can perform measurements on the power line 1610 to detect disturbances such as signal reflections, which may indicate a presence of a downstream disturbance that may impede the propagation of electromagnetic waves on the power line 1610.A signal reflection can represent a distortion resulting from, for example, an electromagnetic wave transmitted on the power line 1610 by the transmission device 101 or 102 that reflects in whole or in part back to the transmission device 101 or 102 from a disturbance in the power line 1610 located downstream from the transmission device 101 or 102.Signal reflections can be caused by obstructions on the power line 1610.For example, a tree limb may cause electromagnetic wave reflections when the tree limb is lying on the power line 1610, or is in close proximity to the power line 1610 which may cause a corona discharge.", "Other obstructions that can cause electromagnetic wave reflections can include without limitation an object that has been entangled on the power line 1610 (e.g., clothing, a shoe wrapped around a power line 1610 with a shoe string, etc.", "), a corroded build-up on the power line 1610 or an ice build-up.", "Power grid components may also impede or obstruct with the propagation of electromagnetic waves on the surface of power lines 1610.Illustrations of power grid components that may cause signal reflections include without limitation a transformer and a joint for connecting spliced power lines.", "A sharp angle on the power line 1610 may also cause electromagnetic wave reflections.", "The disturbance detection sensor 1604b can comprise a circuit to compare magnitudes of electromagnetic wave reflections to magnitudes of original electromagnetic waves transmitted by the transmission device 101 or 102 to determine how much a downstream disturbance in the power line 1610 attenuates transmissions.", "The disturbance detection sensor 1604b can further comprise a spectral analyzer circuit for performing spectral analysis on the reflected waves.", "The spectral data generated by the spectral analyzer circuit can be compared with spectral profiles via pattern recognition, an expert system, curve fitting, matched filtering or other artificial intelligence, classification or comparison technique to identify a type of disturbance based on, for example, the spectral profile that most closely matches the spectral data.", "The spectral profiles can be stored in a memory of the disturbance detection sensor 1604b or may be remotely accessible by the disturbance detection sensor 1604b.", "The profiles can comprise spectral data that models different disturbances that may be encountered on power lines 1610 to enable the disturbance detection sensor 1604b to identify disturbances locally.", "An identification of the disturbance if known can be reported to the network management system 1601 by way of the base station 1614.The disturbance detection sensor 1604b can also utilize the transmission device 101 or 102 to transmit electromagnetic waves as test signals to determine a roundtrip time for an electromagnetic wave reflection.", "The round trip time measured by the disturbance detection sensor 1604b can be used to calculate a distance traveled by the electromagnetic wave up to a point where the reflection takes place, which enables the disturbance detection sensor 1604b to calculate a distance from the transmission device 101 or 102 to the downstream disturbance on the power line 1610.The distance calculated can be reported to the network management system 1601 by way of the base station 1614.In one embodiment, the location of the waveguide system 1602 on the power line 1610 may be known to the network management system 1601, which the network management system 1601 can utilize to determine a location of the disturbance on the power line 1610 based on a known topology of the power grid.", "In another embodiment, the waveguide system 1602 can provide its location to the network management system 1601 to assist in the determination of the location of the disturbance on the power line 1610.The location of the waveguide system 1602 can be obtained by the waveguide system 1602 from a pre-programmed location of the waveguide system 1602 stored in a memory of the waveguide system 1602, or the waveguide system 1602 can determine its location using a GPS receiver (not shown) included in the waveguide system 1602.The power management system 1605 provides energy to the aforementioned components of the waveguide system 1602.The power management system 1605 can receive energy from solar cells, or from a transformer (not shown) coupled to the power line 1610, or by inductive coupling to the power line 1610 or another nearby power line.", "The power management system 1605 can also include a backup battery and/or a super capacitor or other capacitor circuit for providing the waveguide system 1602 with temporary power.", "The loss of energy sensor 1604c can be used to detect when the waveguide system 1602 has a loss of power condition and/or the occurrence of some other malfunction.", "For example, the loss of energy sensor 1604c can detect when there is a loss of power due to defective solar cells, an obstruction on the solar cells that causes them to malfunction, loss of power on the power line 1610, and/or when the backup power system malfunctions due to expiration of a backup battery, or a detectable defect in a super capacitor.", "When a malfunction and/or loss of power occurs, the loss of energy sensor 1604c can notify the network management system 1601 by way of the base station 1614.The noise sensor 1604d can be used to measure noise on the power line 1610 that may adversely affect transmission of electromagnetic waves on the power line 1610.The noise sensor 1604d can sense unexpected electromagnetic interference, noise bursts, or other sources of disturbances that may interrupt reception of modulated electromagnetic waves on a surface of a power line 1610.A noise burst can be caused by, for example, a corona discharge, or other source of noise.", "The noise sensor 1604d can compare the measured noise to a noise profile obtained by the waveguide system 1602 from an internal database of noise profiles or from a remotely located database that stores noise profiles via pattern recognition, an expert system, curve fitting, matched filtering or other artificial intelligence, classification or comparison technique.", "From the comparison, the noise sensor 1604d may identify a noise source (e.g., corona discharge or otherwise) based on, for example, the noise profile that provides the closest match to the measured noise.", "The noise sensor 1604d can also detect how noise affects transmissions by measuring transmission metrics such as bit error rate, packet loss rate, jitter, packet retransmission requests, etc.", "The noise sensor 1604d can report to the network management system 1601 by way of the base station 1614 the identity of noise sources, their time of occurrence, and transmission metrics, among other things.", "The vibration sensor 1604e can include accelerometers and/or gyroscopes to detect 2D or 3D vibrations on the power line 1610.The vibrations can be compared to vibration profiles that can be stored locally in the waveguide system 1602, or obtained by the waveguide system 1602 from a remote database via pattern recognition, an expert system, curve fitting, matched filtering or other artificial intelligence, classification or comparison technique.", "Vibration profiles can be used, for example, to distinguish fallen trees from wind gusts based on, for example, the vibration profile that provides the closest match to the measured vibrations.", "The results of this analysis can be reported by the vibration sensor 1604e to the network management system 1601 by way of the base station 1614.The environmental sensor 1604f can include a barometer for measuring atmospheric pressure, ambient temperature (which can be provided by the temperature sensor 1604a), wind speed, humidity, wind direction, and rainfall, among other things.", "The environmental sensor 1604f can collect raw information and process this information by comparing it to environmental profiles that can be obtained from a memory of the waveguide system 1602 or a remote database to predict weather conditions before they arise via pattern recognition, an expert system, knowledge-based system or other artificial intelligence, classification or other weather modeling and prediction technique.", "The environmental sensor 1604f can report raw data as well as its analysis to the network management system 1601.The image sensor 1604g can be a digital camera (e.g., a charged coupled device or CCD imager, infrared camera, etc.)", "for capturing images in a vicinity of the waveguide system 1602.The image sensor 1604g can include an electromechanical mechanism to control movement (e.g., actual position or focal points/zooms) of the camera for inspecting the power line 1610 from multiple perspectives (e.g., top surface, bottom surface, left surface, right surface and so on).", "Alternatively, the image sensor 1604g can be designed such that no electromechanical mechanism is needed in order to obtain the multiple perspectives.", "The collection and retrieval of imaging data generated by the image sensor 1604g can be controlled by the network management system 1601, or can be autonomously collected and reported by the image sensor 1604g to the network management system 1601.Other sensors that may be suitable for collecting telemetry information associated with the waveguide system 1602 and/or the power lines 1610 for purposes of detecting, predicting and/or mitigating disturbances that can impede the propagation of electromagnetic wave transmissions on power lines 1610 (or any other form of a transmission medium of electromagnetic waves) may be utilized by the waveguide system 1602.Referring now to FIG.", "16B, block diagram 1650 illustrates an example, non-limiting embodiment of a system for managing a power grid 1653 and a communication system 1655 embedded therein or associated therewith in accordance with various aspects described herein.", "The communication system 1655 comprises a plurality of waveguide systems 1602 coupled to power lines 1610 of the power grid 1653.At least a portion of the waveguide systems 1602 used in the communication system 1655 can be in direct communication with a base station 1614 and/or the network management system 1601.Waveguide systems 1602 not directly connected to a base station 1614 or the network management system 1601 can engage in communication sessions with either a base station 1614 or the network management system 1601 by way of other downstream waveguide systems 1602 connected to a base station 1614 or the network management system 1601.The network management system 1601 can be communicatively coupled to equipment of a utility company 1652 and equipment of a communications service provider 1654 for providing each entity, status information associated with the power grid 1653 and the communication system 1655, respectively.", "The network management system 1601, the equipment of the utility company 1652, and the communications service provider 1654 can access communication devices utilized by utility company personnel 1656 and/or communication devices utilized by communications service provider personnel 1658 for purposes of providing status information and/or for directing such personnel in the management of the power grid 1653 and/or communication system 1655.FIG.", "17A illustrates a flow diagram of an example, non-limiting embodiment of a method 1700 for detecting and mitigating disturbances occurring in a communication network of the systems of FIGS.", "16A & 16B.", "Method 1700 can begin with step 1702 where a waveguide system 1602 transmits and receives messages embedded in, or forming part of, modulated electromagnetic waves or another type of electromagnetic waves traveling along a surface of a power line 1610.The messages can be voice messages, streaming video, and/or other data/information exchanged between communication devices communicatively coupled to the communication system 1655.At step 1704 the sensors 1604 of the waveguide system 1602 can collect sensing data.", "In an embodiment, the sensing data can be collected in step 1704 prior to, during, or after the transmission and/or receipt of messages in step 1702.At step 1706 the waveguide system 1602 (or the sensors 1604 themselves) can determine from the sensing data an actual or predicted occurrence of a disturbance in the communication system 1655 that can affect communications originating from (e.g., transmitted by) or received by the waveguide system 1602.The waveguide system 1602 (or the sensors 1604) can process temperature data, signal reflection data, loss of energy data, noise data, vibration data, environmental data, or any combination thereof to make this determination.", "The waveguide system 1602 (or the sensors 1604) may also detect, identify, estimate, or predict the source of the disturbance and/or its location in the communication system 1655.If a disturbance is neither detected/identified nor predicted/estimated at step 1708, the waveguide system 1602 can proceed to step 1702 where it continues to transmit and receive messages embedded in, or forming part of, modulated electromagnetic waves traveling along a surface of the power line 1610.If at step 1708 a disturbance is detected/identified or predicted/estimated to occur, the waveguide system 1602 proceeds to step 1710 to determine if the disturbance adversely affects (or alternatively, is likely to adversely affect or the extent to which it may adversely affect) transmission or reception of messages in the communication system 1655.In one embodiment, a duration threshold and a frequency of occurrence threshold can be used at step 1710 to determine when a disturbance adversely affects communications in the communication system 1655.For illustration purposes only, assume a duration threshold is set to 500 ms, while a frequency of occurrence threshold is set to 5 disturbances occurring in an observation period of 10 sec.", "Thus, a disturbance having a duration greater than 500 ms will trigger the duration threshold.", "Additionally, any disturbance occurring more than 5 times in a 10 sec time interval will trigger the frequency of occurrence threshold.", "In one embodiment, a disturbance may be considered to adversely affect signal integrity in the communication systems 1655 when the duration threshold alone is exceeded.", "In another embodiment, a disturbance may be considered as adversely affecting signal integrity in the communication systems 1655 when both the duration threshold and the frequency of occurrence threshold are exceeded.", "The latter embodiment is thus more conservative than the former embodiment for classifying disturbances that adversely affect signal integrity in the communication system 1655.It will be appreciated that many other algorithms and associated parameters and thresholds can be utilized for step 1710 in accordance with example embodiments.", "Referring back to method 1700, if at step 1710 the disturbance detected at step 1708 does not meet the condition for adversely affected communications (e.g., neither exceeds the duration threshold nor the frequency of occurrence threshold), the waveguide system 1602 may proceed to step 1702 and continue processing messages.", "For instance, if the disturbance detected in step 1708 has a duration of 1 msec with a single occurrence in a 10 sec time period, then neither threshold will be exceeded.", "Consequently, such a disturbance may be considered as having a nominal effect on signal integrity in the communication system 1655 and thus would not be flagged as a disturbance requiring mitigation.", "Although not flagged, the occurrence of the disturbance, its time of occurrence, its frequency of occurrence, spectral data, and/or other useful information, may be reported to the network management system 1601 as telemetry data for monitoring purposes.", "Referring back to step 1710, if on the other hand the disturbance satisfies the condition for adversely affected communications (e.g., exceeds either or both thresholds), the waveguide system 1602 can proceed to step 1712 and report the incident to the network management system 1601.The report can include raw sensing data collected by the sensors 1604, a description of the disturbance if known by the waveguide system 1602, a time of occurrence of the disturbance, a frequency of occurrence of the disturbance, a location associated with the disturbance, parameters readings such as bit error rate, packet loss rate, retransmission requests, jitter, latency and so on.", "If the disturbance is based on a prediction by one or more sensors of the waveguide system 1602, the report can include a type of disturbance expected, and if predictable, an expected time occurrence of the disturbance, and an expected frequency of occurrence of the predicted disturbance when the prediction is based on historical sensing data collected by the sensors 1604 of the waveguide system 1602.At step 1714, the network management system 1601 can determine a mitigation, circumvention, or correction technique, which may include directing the waveguide system 1602 to reroute traffic to circumvent the disturbance if the location of the disturbance can be determined.", "In one embodiment, the waveguide coupling device 1402 detecting the disturbance may direct a repeater such as the one shown in FIGS.", "13-14 to connect the waveguide system 1602 from a primary power line affected by the disturbance to a secondary power line to enable the waveguide system 1602 to reroute traffic to a different transmission medium and avoid the disturbance.", "In an embodiment where the waveguide system 1602 is configured as a repeater the waveguide system 1602 can itself perform the rerouting of traffic from the primary power line to the secondary power line.", "It is further noted that for bidirectional communications (e.g., full or half-duplex communications), the repeater can be configured to reroute traffic from the secondary power line back to the primary power line for processing by the waveguide system 1602.In another embodiment, the waveguide system 1602 can redirect traffic by instructing a first repeater situated upstream of the disturbance and a second repeater situated downstream of the disturbance to redirect traffic from a primary power line temporarily to a secondary power line and back to the primary power line in a manner that avoids the disturbance.", "It is further noted that for bidirectional communications (e.g., full or half-duplex communications), repeaters can be configured to reroute traffic from the secondary power line back to the primary power line.", "To avoid interrupting existing communication sessions occurring on a secondary power line, the network management system 1601 may direct the waveguide system 1602 to instruct repeater(s) to utilize unused time slot(s) and/or frequency band(s) of the secondary power line for redirecting data and/or voice traffic away from the primary power line to circumvent the disturbance.", "At step 1716, while traffic is being rerouted to avoid the disturbance, the network management system 1601 can notify equipment of the utility company 1652 and/or equipment of the communications service provider 1654, which in turn may notify personnel of the utility company 1656 and/or personnel of the communications service provider 1658 of the detected disturbance and its location if known.", "Field personnel from either party can attend to resolving the disturbance at a determined location of the disturbance.", "Once the disturbance is removed or otherwise mitigated by personnel of the utility company and/or personnel of the communications service provider, such personnel can notify their respective companies and/or the network management system 1601 utilizing field equipment (e.g., a laptop computer, smartphone, etc.)", "communicatively coupled to network management system 1601, and/or equipment of the utility company and/or the communications service provider.", "The notification can include a description of how the disturbance was mitigated and any changes to the power lines 1610 that may change a topology of the communication system 1655.Once the disturbance has been resolved (as determined in decision 1718), the network management system 1601 can direct the waveguide system 1602 at step 1720 to restore the previous routing configuration used by the waveguide system 1602 or route traffic according to a new routing configuration if the restoration strategy used to mitigate the disturbance resulted in a new network topology of the communication system 1655.In another embodiment, the waveguide system 1602 can be configured to monitor mitigation of the disturbance by transmitting test signals on the power line 1610 to determine when the disturbance has been removed.", "Once the waveguide system 1602 detects an absence of the disturbance it can autonomously restore its routing configuration without assistance by the network management system 1601 if it determines the network topology of the communication system 1655 has not changed, or it can utilize a new routing configuration that adapts to a detected new network topology.", "FIG.", "17B illustrates a flow diagram of an example, non-limiting embodiment of a method 1750 for detecting and mitigating disturbances occurring in a communication network of the system of FIGS.", "16A and 16B.", "In one embodiment, method 1750 can begin with step 1752 where a network management system 1601 receives from equipment of the utility company 1652 or equipment of the communications service provider 1654 maintenance information associated with a maintenance schedule.", "The network management system 1601 can at step 1754 identify from the maintenance information, maintenance activities to be performed during the maintenance schedule.", "From these activities, the network management system 1601 can detect a disturbance resulting from the maintenance (e.g., scheduled replacement of a power line 1610, scheduled replacement of a waveguide system 1602 on the power line 1610, scheduled reconfiguration of power lines 1610 in the power grid 1653, etc.).", "In another embodiment, the network management system 1601 can receive at step 1755 telemetry information from one or more waveguide systems 1602.The telemetry information can include among other things an identity of each waveguide system 1602 submitting the telemetry information, measurements taken by sensors 1604 of each waveguide system 1602, information relating to predicted, estimated, or actual disturbances detected by the sensors 1604 of each waveguide system 1602, location information associated with each waveguide system 1602, an estimated location of a detected disturbance, an identification of the disturbance, and so on.", "The network management system 1601 can determine from the telemetry information a type of disturbance that may be adverse to operations of the waveguide, transmission of the electromagnetic waves along the wire surface, or both.", "The network management system 1601 can also use telemetry information from multiple waveguide systems 1602 to isolate and identify the disturbance.", "Additionally, the network management system 1601 can request telemetry information from waveguide systems 1602 in a vicinity of an affected waveguide system 1602 to triangulate a location of the disturbance and/or validate an identification of the disturbance by receiving similar telemetry information from other waveguide systems 1602.In yet another embodiment, the network management system 1601 can receive at step 1756 an unscheduled activity report from maintenance field personnel.", "Unscheduled maintenance may occur as result of field calls that are unplanned or as a result of unexpected field issues discovered during field calls or scheduled maintenance activities.", "The activity report can identify changes to a topology configuration of the power grid 1653 resulting from field personnel addressing discovered issues in the communication system 1655 and/or power grid 1653, changes to one or more waveguide systems 1602 (such as replacement or repair thereof), mitigation of disturbances performed if any, and so on.", "At step 1758, the network management system 1601 can determine from reports received according to steps 1752 through 1756 if a disturbance will occur based on a maintenance schedule, or if a disturbance has occurred or is predicted to occur based on telemetry data, or if a disturbance has occurred due to an unplanned maintenance identified in a field activity report.", "From any of these reports, the network management system 1601 can determine whether a detected or predicted disturbance requires rerouting of traffic by the affected waveguide systems 1602 or other waveguide systems 1602 of the communication system 1655.When a disturbance is detected or predicted at step 1758, the network management system 1601 can proceed to step 1760 where it can direct one or more waveguide systems 1602 to reroute traffic to circumvent the disturbance.", "When the disturbance is permanent due to a permanent topology change of the power grid 1653, the network management system 1601 can proceed to step 1770 and skip steps 1762, 1764, 1766, and 1772.At step 1770, the network management system 1601 can direct one or more waveguide systems 1602 to use a new routing configuration that adapts to the new topology.", "However, when the disturbance has been detected from telemetry information supplied by one or more waveguide systems 1602, the network management system 1601 can notify maintenance personnel of the utility company 1656 or the communications service provider 1658 of a location of the disturbance, a type of disturbance if known, and related information that may be helpful to such personnel to mitigate the disturbance.", "When a disturbance is expected due to maintenance activities, the network management system 1601 can direct one or more waveguide systems 1602 to reconfigure traffic routes at a given schedule (consistent with the maintenance schedule) to avoid disturbances caused by the maintenance activities during the maintenance schedule.", "Returning back to step 1760 and upon its completion, the process can continue with step 1762.At step 1762, the network management system 1601 can monitor when the disturbance(s) have been mitigated by field personnel.", "Mitigation of a disturbance can be detected at step 1762 by analyzing field reports submitted to the network management system 1601 by field personnel over a communications network (e.g., cellular communication system) utilizing field equipment (e.g., a laptop computer or handheld computer/device).", "If field personnel have reported that a disturbance has been mitigated, the network management system 1601 can proceed to step 1764 to determine from the field report whether a topology change was required to mitigate the disturbance.", "A topology change can include rerouting a power line 1610, reconfiguring a waveguide system 1602 to utilize a different power line 1610, otherwise utilizing an alternative link to bypass the disturbance and so on.", "If a topology change has taken place, the network management system 1601 can direct at step 1770 one or more waveguide systems 1602 to use a new routing configuration that adapts to the new topology.", "If, however, a topology change has not been reported by field personnel, the network management system 1601 can proceed to step 1766 where it can direct one or more waveguide systems 1602 to send test signals to test a routing configuration that had been used prior to the detected disturbance(s).", "Test signals can be sent to affected waveguide systems 1602 in a vicinity of the disturbance.", "The test signals can be used to determine if signal disturbances (e.g., electromagnetic wave reflections) are detected by any of the waveguide systems 1602.If the test signals confirm that a prior routing configuration is no longer subject to previously detected disturbance(s), then the network management system 1601 can at step 1772 direct the affected waveguide systems 1602 to restore a previous routing configuration.", "If, however, test signals analyzed by one or more waveguide coupling device 1402 and reported to the network management system 1601 indicate that the disturbance(s) or new disturbance(s) are present, then the network management system 1601 will proceed to step 1768 and report this information to field personnel to further address field issues.", "The network management system 1601 can in this situation continue to monitor mitigation of the disturbance(s) at step 1762.In the aforementioned embodiments, the waveguide systems 1602 can be configured to be self-adapting to changes in the power grid 1653 and/or to mitigation of disturbances.", "That is, one or more affected waveguide systems 1602 can be configured to self-monitor mitigation of disturbances and reconfigure traffic routes without requiring instructions to be sent to them by the network management system 1601.In this embodiment, the one or more waveguide systems 1602 that are self-configurable can inform the network management system 1601 of its routing choices so that the network management system 1601 can maintain a macro-level view of the communication topology of the communication system 1655.While for purposes of simplicity of explanation, the respective processes are shown and described as a series of blocks in FIGS.", "17A and 17B, respectively, it is to be understood and appreciated that the claimed subject matter is not limited by the order of the blocks, as some blocks may occur in different orders and/or concurrently with other blocks from what is depicted and described herein.", "Moreover, not all illustrated blocks may be required to implement the methods described herein.", "Turning now to FIG.", "18, a system 1800 is illustrated in which software can be efficiently distributed throughout a network or a targeted portion thereof utilizing network devices 1806.The software can be directed to the network devices 1806 and/or other devices, including customer premises equipment and/or end user devices such as located at residence 1835.System 1800 provides for a de-centralized process that distributes software and/or that locally validates the software being distributed.", "The distributed software can be any type of software that includes executable instructions.", "The software can be updates to existing software at the network device, software that is associated with or usable by existing software at the network device, and/or software that is unrelated to software existing at the network device.", "Many of the examples herein describe a de-centralized process and system for distributing software updates (or patches), however, the exemplary embodiments can be utilized for any type of software that may or may not be an update to software already existing at the network device(s).", "In one or more embodiments, the distributed software can be used for adjusting operations at the network device(s).", "The operations being adjusted can vary and can include changing the operation of the operating system at the network device, providing new functions at the network device, adjusting existing functions at the network device, changing communication protocols (e.g., transmitting protocols, security protocols, authentication protocols, encryption protocols, and so forth) utilized by the network device, and so forth.", "The communication system 1800 provides for a peer-to-peer (p2p) model where network nodes can be active agents in obtaining or distributing software updates without the necessity of direct communication of updates from a network source.", "In one embodiment, the network devices 1806 can poll other network device(s), such as located at parent pathway nodes, for information on software update versions to determine whether an update is available and if so, when to install the software update.", "In one embodiment, the network devices 1806 can be network nodes that are dynamically organized into a configuration from an update root node down to terminal nodes, and intermediate nodes can act as update servers for child nodes further along the communication path.", "In another embodiment, an update management or source server can provide an initial update package (e.g., including desired update(s), upgrade(s), and/or patch(es)) into a targeted network (e.g., providing services to end user devices, m2m, IoT or similar devices) at a designated update root node(s).", "Various distribution processes can then be implemented.", "For example, the designated update root node (e.g., network device 1806A) can propagate the software update down or through a tree-like topology to other network devices and other terminal nodes.", "In another example, other network node(s) in the network can be selected, either randomly or based on one or more criteria, as a starting point for the P2P distribution of the software update.", "For instance, the initial drop of the software update can be over a wired network to a selected network device.", "In another example, the initial drop of the software update can be via a wireless network, such as a cellular network.", "In another embodiment, multiple initial drop points (e.g., selected network devices) can be utilized.", "For instance, if the targeted local network is large and/or the software update is urgent, system 1800 can utilize two or more initial drop points (e.g., located at opposing ends of a targeted network), which can then propagate the software update (e.g., to separate sections of the network) and can reduce the overall distribution time to all nodes and/or devices.", "In one embodiment, the network can be divided or otherwise categorized into portions to facilitate propagation of the software updates.", "For example, neighborhoods or sub-networks 1825 (only one of which is shown) can be designated according to a group of network devices 1806 (only four of which are shown) that provide a service area for communication devices located in or otherwise associated with particular areas.", "The particular network devices 1806 and the resulting service area can be selected based on various factors including one or more of boundaries of a physical neighborhood, premises having common characteristics or interests (e.g., proximity to same stores, attractions, public services, user demographics and so forth), similar infrastructure in a particular area, and so forth.", "In one embodiment, some or all devices of the group of network devices 1806 can be the closest network nodes that provide communication services to the premises in the designated area, such as a residence 1835.The neighborhood network can provide a contiguous service area or can provide separated sub-service areas that make up the designated area.", "The premises served by the neighborhood network can include various types of premises including residential houses and/or buildings, commercial stores and facilities, government buildings, public areas and so forth.", "In a de-centralized fashion, software updates can be propagated, such as at the same or overlapping time period, over multiple designated neighborhood networks 1825.In addition to distributing software updates, system 1800 can be used for various types of communications including voice, video, data and/or messaging.", "System 1800 can include network devices 1806 of various numbers (four of which are illustrated) and in various configurations (for ease of illustration being depicted in a straight path).", "In one embodiment, each of the network devices 1806 can be a network node.", "In another embodiment, the network devices 1806 can be a plurality of waveguide systems, such as waveguide systems 1806A-1806D.", "Waveguide systems 1806A-1806D can be nodes of a wired network, which, for example, can include power lines 1802 as a transmission medium.", "In one embodiment, the waveguide systems 1806A-1806D can enable electromagnetic waves to be received at a physical interface of a transmission medium without utilizing an electrical return path, where the electromagnetic waves are guided by the transmission medium, and where the electromagnetic waves have a non-optical frequency range.", "The electromagnetic waves can carry or convey various information, such as software updates, authentication information, and so forth.", "While the communication device(s) illustrated in system 1800 are network devices and, particularly, waveguide systems, one or more of the exemplary embodiments can also include other types of devices coupled with a wired network and/or a wireless network that enable a de-centralized distribution of software updates.", "One or more of the waveguide systems 1806A-1806D (or other devices operating as the network devices) can include a processor 1816 that can perform various functions including one or more of authenticating other network devices; receiving and/or transmitting software updates (e.g., without the need to directly receive the software update from a network source server); adjusting operations according to software updates; providing a digital signature to the software update to generate an adjusted software update where the digital signature indicates that the network device has received and/or installed the software update; comparing software updates to determine which software update is to be utilized and/or to be forwarded to another network device(s); transmitting update requests to another network device or to a group of network devices without providing the update request to a network source server that originated the software update; determining a latest version of software updates being stored by other network devices; determining an applicability of the software update to the operations of the particular network device where the adjusting of the operations at the network device is responsive to a determination that the software update is applicable to the operations of the network device; identifying network devices from a group of digital signatures included with a software update; comparing the identified network devices to expected network devices along an expected communication path of the software update; determining a hierarchical configuration of network devices; discarding particular software updates according to a determination that a network device is a parent node and that another network device is a child node; monitoring for an expiration of software operating at the network device; and/or transmitting an update request to another network device responsive to determining that software has expired.", "In one embodiment, a first non-root node network device can receive a software update from a second-non-root node network device without directly receiving the software update from a root node network device (e.g., a patch drop point in the network).", "The processor 1816 can be a separate device in communication with, or otherwise coupled to, the waveguide guide systems 1806A-1806D (as shown with respect to waveguide systems 1806B and 1806D) or can be integrated with the waveguide systems, such as shown with respect to waveguide systems 1806A and 1806C.", "In one embodiment, the waveguide system 1806B can be a closest network node to a subset of the group of recipient devices (e.g., a recipient device located at premises 1835) and can deliver information to the premises 1835, as well as deliver the information to a next adjacent node (e.g., third waveguide system 1806C) for further delivery to other devices of the group of recipient devices and/or to other network devices of the neighborhood network 1825.In one embodiment, waveguide system 1806A can be an edge node of the neighborhood network that receives data including a software update from an external network device 1850 and that determines that the data is to be distributed to other network devices 1806.Turning now to FIG.", "19, system 1900 is illustrated which includes an access network 1918 coupled with a core network 1932 and with a group of network servers 1850 to deliver communication services to customer premises equipment and/or end user devices 1925.Any number of network servers 1850 can be used for providing services that enable peer-to-peer authentication between network devices 1806 in the access network 1918, as well as a de-centralized propagation of software updates throughout the access network and/or to the devices 1925.In one embodiment, the network servers 1850 can be part of the core network 1932.The network devices 1806 can be waveguide systems and/or can be other types of network devices, including routers and/or DSLAMs.", "In one embodiment, the network device(s) 1806A can be selected as an initial drop point for distributing a software update 1960 throughout the access network 1918.The selection process can be based on various criteria, including the configuration of the access network 1918, the position of the network device 1806A in a hierarchy of network devices, the capabilities of the network device, the type of software update 1960, and so forth.", "In another embodiment, the selection of the network device 1806A as the initial drop point can be based on past update distributions.", "For example, timing performance (e.g., time to complete the distribution to all or some of the network devices) can be monitored for different initial drop points to determine which network drop point(s) most effectively and efficiently previously distributed software updates.", "The network server 1850 can provide the network device 1806A the software update 1960 utilizing wireless and/or wired communications.", "In one embodiment, system 1900 can transmit the software update 1960 in a store-and-forward model between peer nodes (e.g., the network devices 1806) that are mutually authenticating each other.", "The initial drop node (e.g., network device 1806A) can propagate the software update 1960 it to its neighbor node(s), each of the network nodes applying the software update as appropriate (given that some software updates might not apply to all devices, but only to some types thereof) and then forwarding the software update to the next adjacent node(s).", "The software update 1960 can be transmitted from node to node (e.g., from network device 1806A to network device(s) 1806B to network device(s) 1806B and so on), in a peer-to-peer communication and viral-type fashion without needing to directly receive the software update from the source originating it (e.g., network server 1850) and/or without communicating with the source (e.g., without transmitting a receipt acknowledgement to the network server 1850).", "In one embodiment, each of the network devices 1806 can authenticate each other with mutual authentication thereby preventing or reducing sending/receiving software updates to/from a possibly malicious or compromised node.", "In another embodiment, system 1900 can implement an update ready check.", "For example, each or some of the network nodes (e.g., network devices 1806) can maintain a version list of update histories, such as to support roll backs.", "Software update versions can have a date of issue and/or a date of expiry.", "When a network device 1806 determines that its current software version is expired, the network device can initiate an update.", "In one embodiment, a network device can, independent of or prior to version expiry, periodically poll other network devices, such as at parent nodes (all or some), for their current version number (or other information that indicates the identity of the version being utilized at the other network device).", "In some instances, such as where a local network is large and parent pathways are long, an upper limit on the hierarchy tree can be utilized.", "For example, each network device 1806B may only check the status of a maximum number of network devices located at parent network nodes before validating a software update.", "If a number of network devices 1806 at the parent nodes (e.g., satisfying a threshold) have a more up-to-date version of the software update 1960 then the current network device can request the software update (e.g., from one of the polled network devices at the parent nodes) and can trigger an update during the next maintenance window.", "In another embodiment, system 1900 can implement an update check.", "For example, network devices can validate the source of the software update 1960 by authenticating the network devices at parent node(s) that the software update was received from.", "As a software update 1960 is transmitted from the network server 1850 through a path of network nodes (where the network devices are located), each network device can digitally sign (or otherwise provide an indication that the network device has received the software update) the update package.", "Before installing the software update 1960, a network device can validate the digital signatures of all the network devices on the path, such as based on a comparison to a list of expected network devices along the path.", "In one embodiment, any software update that fails these tests can be discarded.", "The software update package can be digitally signed, and receiving devices can check the signature, so tampering for all software update packages can be detected without delay, and tampered or forged software updates can be removed.", "In another embodiment, system 1900 can implement conflict prevention.", "For example, network devices can have alternate means of receiving software updates.", "For instance, a single network node may have redundancy within the network either through another path way to a different node, to be used in the event of a failure, or through a separate transport mechanism.", "Examples can include out of band management pathways and/or the mobility network.", "In this embodiment, a network device can validate multiple paths to different update root nodes from which the software update is being received.", "In one embodiment, one pathway can be designated as a parent pathway by a priority selection process.", "In the event of a failure on the parent pathway, an alternate pathway to the update root node can be selected.", "In this example, a network device that has received a software update from an alternate path can communicate the existence of the software update to all its parent nodes, triggering a query by each parent node for an updated software version.", "In one embodiment, to prevent update loops, where a network device receives information about a software update from both parent and child nodes, the software update file may only be accepted from the parent pathway.", "In the event that a network node fails on a parent pathway, and a secondary pathway exists, then if that secondary path leads to a parent node earlier in the path it can be selected.", "Continuing with this example, the software update can then be received from the immediate parent node on the alternate pathway.", "When the primary pathway is restored, a child node may have a more current version of the software update than its parent nodes.", "The child node (or another node along the path) can then trigger an update request to all the nodes on the parent pathway, which can then start the process of obtaining the most up-to-date version of the software update.", "Various authentication methods can be used as part of the de-centralized distribution of software updates.", "In one embodiment, waveguide system 1806A (e.g., operating as an edge element or update root node) can be validated (e.g., by another waveguide system or a network server) according to an identification in an inventory database and/or an association with a specific network modification request.", "In another embodiment, waveguide system 1806B (e.g., operating as a non-edge element or a non-update root node) can be validated (e.g., by another waveguide system or a network server) according to an identification in an inventory database, being mapped to a valid location in the topology of its corresponding root node (waveguide system operating as an edge element), and/or having a specific upstream waveguide system which can be an edge element or a non-edge element.", "As an example, component services can be implemented by network servers 1850, including an inventory service, a deployment service, and a modification management service that can be utilized for this validation process.", "In one embodiment, whenever customers are added to the communication services provided via system 1900, they are introduced as terminal nodes at the end of the transport pathway that are provided via the non-edge waveguide systems.", "In one embodiment, a terminal node can be user equipment as in an LTE use case, or can be a modem supporting a home network, cable, or voice services.", "Other security protocols can be implemented to prevent bogus clients joining the network by confirming identity using existing protocols, such as LTE or DOCSIS3.0 AAA protocols, and/or querying a customer profile service before allowing registration.", "In one or more embodiments, peer-to-peer authentication between network devices can be performed, such as described in U.S. application Ser.", "No.", "14/737,983, the disclosure of which is hereby incorporated by reference.", "The example of system 1900 describes particular components and examples of handshake protocols, however, the peer-to-peer authentication being utilized or a portion thereof can be extended to other transport networks.", "Further, a subset of the exemplary protocols can be used and other protocols and components, based on the underlying transport technology specifics, can also be utilized with the exemplary embodiments.", "Turning now to FIG.", "20, a flow diagram of an example, non-limiting embodiment of a method 2000, is shown.", "In particular, a method is presented for use with one or more functions and features presented in conjunction with FIGS.", "1-19.Method 2000 enables distributing software updates in a de-centralized process.", "Systems 1800 and 1900 of FIGS.", "18, 19 are described with respect to waveguide systems and method 2000 can be performed in conjunction with these systems.", "However, one or more embodiments of method 2000 (including all or some of the features described herein) can be performed using other types of network components and/or other architectures including in a wired network and/or a wireless network.", "Method 2000 is described as being performed by one or more network devices.", "At 2005, a network device operating as a node of a network can receive data of various types, including voice, video, and/or messaging.", "The data can include a software update.", "In one embodiment, the network device can be operating as a non-edge node and the data can be received from an adjacent network node, such as along a path extending from or to an edge node (or update root node).", "In another embodiment, the network device can be operating as an edge node and the data can be received from an external network device positioned outside of the neighborhood network.", "At 2010, the network device can determine if the received software update is a valid update.", "In one embodiment, the network device can perform authentication, such as mutual authentication, with the network device that transmitted the software update (e.g., an adjacent network node).", "In one embodiment, the network device can detect or otherwise identify digital signature(s) or other indicia that are provided with the software update.", "The digital signatures can be provided by other network devices that have received and forwarded the software update.", "In this example, the network device can compare these identified network devices with expected network devices that should have been along the communication path.", "In the event that a software update is determined to be invalid then at 2015 the software update can be discarded or otherwise flagged as invalid.", "In one embodiment, a notification can be generated and transmitted to other network devices and/or to a network server so that further investigation or actions can be performed with respect to the invalid software update.", "If on the other hand, the software update is determined to be valid then at 2020 the software update can be implemented or otherwise installed at the network device, so as to adjust operations of the network device.", "In one embodiment, the network device can determine whether the software update is applicable to the particular network device.", "For example, the software update can be directed to particular types of network devices but not to other types.", "In another example, the network device may already be updated with the received software update and/or may have a more up-to-date version of the software.", "At 2025, the network device can provide a digital signature or other indicia that indicates that the network device has received the software update.", "In one embodiment, the digital signature or other indicia can indicate whether or not the transmitting network device implemented the software update.", "The added digital signature can then be utilized by a receiving network device to validate the software update.", "At 2030, the software update can be transmitted by the network device to one or more other network devices, such as adjacent network node(s).", "In one embodiment, the network devices can be waveguide systems that transmit and receive electromagnetic waves at a physical interface of a transmission medium, wherein the electromagnetic waves are guided by the transmission medium without utilizing an electrical return path, wherein the electromagnetic waves have a non-optical frequency range, and wherein the authentication information, the software update and/or the adjusted software update are conveyed via the electromagnetic waves.", "In another embodiment, multiple software updates can be received by a network device from multiple other network devices (e.g., along a single communication path or along several communication paths).", "In this example, the software updates can be compared and the latest version of the software update can be utilized.", "In one embodiment, a first network device, responsive to determining that a software update received from a second network device is out-of-date or not the latest version, can notify the second network device of the existence of (or provide to the second network device) the more-up-to-date version of the software update.", "In one embodiment, the network device can transmit an update request to one network device or to a group of network devices, where the transmitting of the update request does not include providing the update request to a network source server that originated the software update.", "In this example, the network device can determine a latest version of the software update being stored by each of the group of network device and can then obtain that latest version from the particular network device.", "In one embodiment, the network device can determine a hierarchical configuration of other network devices and can discard particular software updates according to a determination as to whether the update was received from a parent node (e.g., keep the update) or a child node (discard the update).", "In one embodiment, the network device can monitor for an expiration of software operating at the network device, and, responsive to a determination that the software has expired, transmit an update request to another network device, where the transmitting of the update request does not include providing the update request to a network source server that originated the software update, While for purposes of simplicity of explanation, the respective processes are shown and described as a series of blocks in FIG.", "20, it is to be understood and appreciated that the claimed subject matter is not limited by the order of the blocks, as some blocks may occur in different orders and/or concurrently with other blocks from what is depicted and described herein.", "Moreover, not all illustrated blocks may be required to implement the methods described herein.", "In one embodiment, each network device can maintain a ‘last known good configuration’.", "In order to prevent update flapping, roll backs can require additional validation that the current update has been fixed before a reinstall is initiated.", "In one embodiment, if multiple updates are available, a protocol can be used to check the types of each update.", "If a series of updates is required to be applied in order, the network device can do so.", "If a fresh update replaces all prior updates, the earlier updates can be discarded unless needed for a ‘last known good configuration’.", "In one embodiment, even when an update package is correctly received by a network device, and its integrity is verified (e.g., via digital signatures), more checking can be performed to assure upgrade-only patching, so the device goes to the most recent version, and not to an older patch which might actually re-instate a vulnerability.", "An increasing release number can be associated with each software update and checked by each receiving network device.", "In one embodiment, for emergency situations when reverting to a slightly older version is actually required in operation, the update can have a new, increased version number, to facilitate checking.", "In one embodiment, accounting for differences in actual hardware can be performed.", "For example, software updates may not apply to network devices on a parent path if the network devices are manufactured by different vendors or if the actual hardware is not certified for the update.", "All network devices can still support the update protocols so that they can communicate updates downstream.", "In heterogeneous environments, network devices can apply a majority controls polling rule to account for this possibility.", "In one embodiment, gold standard auditing can be performed.", "For example, all the nodes in the network can be polled on their current configuration to ensure that they are indeed compliant with current versions and configuration parameters.", "Deviations from a gold standard can be reported to system logs and can generate alerts.", "In one embodiment, transaction-based processing of updates can be performed.", "For example, update operations can be transactional (e.g., either the full update installation is completed, or none of it is installed).", "If an update fails, the network device can roll back to a valid state and/or can return to an active state.", "In one embodiment, patch propagation for non-like devices communicating to pass along the update can be performed.", "For example, a local IoT network can comprise devices of different types, (e.g., in a smart home, there are many types of appliances and devices that communicate with one another).", "A new software update can be for a specific type of device, and not apply to other types.", "In this example, the software update can include an indicator that specifies the type of device(s) it targets.", "After the initial drop, the receiving network device can inspect the indicator, and then pass the software update along to network devices that can use it.", "This can be implemented through device self-awareness and the receiving network device also knows the device type of its neighbors.", "When receiving a software update, the receiving network device can compare the patch's applicable device type indicator with the known types of its downstream network devices, and then can send the patch to applicable devices only.", "This example can save propagation time and resources.", "Devices that are along a required path and that receive non-applicable software updates for relaying them further down still save processing time as they only need to inspect the patch indicator, but not the entire software update.", "In one embodiment, the exemplary systems and methods can reduce network usage along with dependency on centralized update management.", "The distributed update management of the exemplary embodiments can support self-healing and self-managing networks that are more robust in the face of failure and that can propagate corrections through the network automatically.", "For example, the exemplary embodiments can reduce wide area network usage.", "For instance, large updates can be sent only once—from the central server to the drop node(s)—instead of to each node individually.", "This cuts down significantly the Wide Area Network (WAN) communications, saving WAN bandwidth (which is typically lower than local capacity).", "The exemplary embodiments can reduce the load on central servers from communication and processing.", "For example, the central servers do not need to communicate with each network device, thereby reducing their communication load.", "Also there is no need to receive and process responses from all network devices, thereby reducing processing load for the central servers.", "Referring now to FIG.", "21, there is illustrated a block diagram of a computing environment in accordance with various aspects described herein.", "In order to provide additional context for various embodiments of the embodiments described herein, FIG.", "21 and the following discussion are intended to provide a brief, general description of a suitable computing environment 2100 in which the various embodiments of the subject disclosure can be implemented.", "While the embodiments have been described above in the general context of computer-executable instructions that can run on one or more computers, those skilled in the art will recognize that the embodiments can be also implemented in combination with other program modules and/or as a combination of hardware and software.", "Generally, program modules comprise routines, programs, components, data structures, etc., that perform particular tasks or implement particular abstract data types.", "Moreover, those skilled in the art will appreciate that the inventive methods can be practiced with other computer system configurations, comprising single-processor or multiprocessor computer systems, minicomputers, mainframe computers, as well as personal computers, hand-held computing devices, microprocessor-based or programmable consumer electronics, and the like, each of which can be operatively coupled to one or more associated devices.", "As used herein, a processing circuit includes processor as well as other application specific circuits such as an application specific integrated circuit, digital logic circuit, state machine, programmable gate array or other circuit that processes input signals or data and that produces output signals or data in response thereto.", "It should be noted that while any functions and features described herein in association with the operation of a processor could likewise be performed by a processing circuit.", "The terms “first,” “second,” “third,” and so forth, as used in the claims, unless otherwise clear by context, is for clarity only and doesn't otherwise indicate or imply any order in time.", "For instance, “a first determination,” “a second determination,” and “a third determination,” does not indicate or imply that the first determination is to be made before the second determination, or vice versa, etc.", "The illustrated embodiments of the embodiments herein can be also practiced in distributed computing environments where certain tasks are performed by remote processing devices that are linked through a communications network.", "In a distributed computing environment, program modules can be located in both local and remote memory storage devices.", "Computing devices typically comprise a variety of media, which can comprise computer-readable storage media and/or communications media, which two terms are used herein differently from one another as follows.", "Computer-readable storage media can be any available storage media that can be accessed by the computer and comprises both volatile and nonvolatile media, removable and non-removable media.", "By way of example, and not limitation, computer-readable storage media can be implemented in connection with any method or technology for storage of information such as computer-readable instructions, program modules, structured data or unstructured data.", "Computer-readable storage media can comprise, but are not limited to, random access memory (RAM), read only memory (ROM), electrically erasable programmable read only memory (EEPROM),flash memory or other memory technology, compact disk read only memory (CD-ROM), digital versatile disk (DVD) or other optical disk storage, magnetic cassettes, magnetic tape, magnetic disk storage or other magnetic storage devices or other tangible and/or non-transitory media which can be used to store desired information.", "In this regard, the terms “tangible” or “non-transitory” herein as applied to storage, memory or computer-readable media, are to be understood to exclude only propagating transitory signals per se as modifiers and do not relinquish rights to all standard storage, memory or computer-readable media that are not only propagating transitory signals per se.", "Computer-readable storage media can be accessed by one or more local or remote computing devices, e.g., via access requests, queries or other data retrieval protocols, for a variety of operations with respect to the information stored by the medium.", "Communications media typically embody computer-readable instructions, data structures, program modules or other structured or unstructured data in a data signal such as a modulated data signal, e.g., a carrier wave or other transport mechanism, and comprises any information delivery or transport media.", "The term “modulated data signal” or signals refers to a signal that has one or more of its characteristics set or changed in such a manner as to encode information in one or more signals.", "By way of example, and not limitation, communication media comprise wired media, such as a wired network or direct-wired connection, and wireless media such as acoustic, RF, infrared and other wireless media.", "With reference again to FIG.", "21, the example environment 2100 for transmitting and receiving signals via or forming at least part of a base station (e.g., base station devices 1504, macrocell site 1502, or base stations 1614) or central office (e.g., central office 1501 or 1611).", "At least a portion of the example environment 2100 can also be used for transmission devices 101 or 102.The example environment can comprise a computer 2102, the computer 2102 comprising a processing unit 2104, a system memory 2106 and a system bus 2108.The system bus 2108 couples system components including, but not limited to, the system memory 2106 to the processing unit 2104.The processing unit 2104 can be any of various commercially available processors.", "Dual microprocessors and other multiprocessor architectures can also be employed as the processing unit 2104.The system bus 2108 can be any of several types of bus structure that can further interconnect to a memory bus (with or without a memory controller), a peripheral bus, and a local bus using any of a variety of commercially available bus architectures.", "The system memory 2106 comprises ROM 2110 and RAM 2112.A basic input/output system (BIOS) can be stored in a non-volatile memory such as ROM, erasable programmable read only memory (EPROM), EEPROM, which BIOS contains the basic routines that help to transfer information between elements within the computer 2102, such as during startup.", "The RAM 2112 can also comprise a high-speed RAM such as static RAM for caching data.", "The computer 2102 further comprises an internal hard disk drive (HDD) 2114 (e.g., EIDE, SATA), which internal hard disk drive 2114 can also be configured for external use in a suitable chassis (not shown), a magnetic floppy disk drive (FDD) 2116, (e.g., to read from or write to a removable diskette 2118) and an optical disk drive 2120, (e.g., reading a CD-ROM disk 2122 or, to read from or write to other high capacity optical media such as the DVD).", "The hard disk drive 2114, magnetic disk drive 2116 and optical disk drive 2120 can be connected to the system bus 2108 by a hard disk drive interface 2124, a magnetic disk drive interface 2126 and an optical drive interface 2128, respectively.", "The interface 2124 for external drive implementations comprises at least one or both of Universal Serial Bus (USB) and Institute of Electrical and Electronics Engineers (IEEE) 1394 interface technologies.", "Other external drive connection technologies are within contemplation of the embodiments described herein.", "The drives and their associated computer-readable storage media provide nonvolatile storage of data, data structures, computer-executable instructions, and so forth.", "For the computer 2102, the drives and storage media accommodate the storage of any data in a suitable digital format.", "Although the description of computer-readable storage media above refers to a hard disk drive (HDD), a removable magnetic diskette, and a removable optical media such as a CD or DVD, it should be appreciated by those skilled in the art that other types of storage media which are readable by a computer, such as zip drives, magnetic cassettes, flash memory cards, cartridges, and the like, can also be used in the example operating environment, and further, that any such storage media can contain computer-executable instructions for performing the methods described herein.", "A number of program modules can be stored in the drives and RAM 2112, comprising an operating system 2130, one or more application programs 2132, other program modules 2134 and program data 2136.All or portions of the operating system, applications, modules, and/or data can also be cached in the RAM 2112.The systems and methods described herein can be implemented utilizing various commercially available operating systems or combinations of operating systems.", "Examples of application programs 2132 that can be implemented and otherwise executed by processing unit 2104 include the diversity selection determining performed by transmission device 101 or 102.A user can enter commands and information into the computer 2102 through one or more wired/wireless input devices, e.g., a keyboard 2138 and a pointing device, such as a mouse 2140.Other input devices (not shown) can comprise a microphone, an infrared (IR) remote control, a joystick, a game pad, a stylus pen, touch screen or the like.", "These and other input devices are often connected to the processing unit 2104 through an input device interface 2142 that can be coupled to the system bus 2108, but can be connected by other interfaces, such as a parallel port, an IEEE 1394 serial port, a game port, a universal serial bus (USB) port, an IR interface, etc.", "A monitor 2144 or other type of display device can be also connected to the system bus 2108 via an interface, such as a video adapter 2146.It will also be appreciated that in alternative embodiments, a monitor 2144 can also be any display device (e.g., another computer having a display, a smart phone, a tablet computer, etc.)", "for receiving display information associated with computer 2102 via any communication means, including via the Internet and cloud-based networks.", "In addition to the monitor 2144, a computer typically comprises other peripheral output devices (not shown), such as speakers, printers, etc.", "The computer 2102 can operate in a networked environment using logical connections via wired and/or wireless communications to one or more remote computers, such as a remote computer(s) 2148.The remote computer(s) 2148 can be a workstation, a server computer, a router, a personal computer, portable computer, microprocessor-based entertainment appliance, a peer device or other common network node, and typically comprises many or all of the elements described relative to the computer 2102, although, for purposes of brevity, only a memory/storage device 2150 is illustrated.", "The logical connections depicted comprise wired/wireless connectivity to a local area network (LAN) 2152 and/or larger networks, e.g., a wide area network (WAN) 2154.Such LAN and WAN networking environments are commonplace in offices and companies, and facilitate enterprise-wide computer networks, such as intranets, all of which can connect to a global communications network, e.g., the Internet.", "When used in a LAN networking environment, the computer 2102 can be connected to the local network 2152 through a wired and/or wireless communication network interface or adapter 2156.The adapter 2156 can facilitate wired or wireless communication to the LAN 2152, which can also comprise a wireless AP disposed thereon for communicating with the wireless adapter 2156.When used in a WAN networking environment, the computer 2102 can comprise a modem 2158 or can be connected to a communications server on the WAN 2154 or has other means for establishing communications over the WAN 2154, such as by way of the Internet.", "The modem 2158, which can be internal or external and a wired or wireless device, can be connected to the system bus 2108 via the input device interface 2142.In a networked environment, program modules depicted relative to the computer 2102 or portions thereof, can be stored in the remote memory/storage device 2150.It will be appreciated that the network connections shown are example and other means of establishing a communications link between the computers can be used.", "The computer 2102 can be operable to communicate with any wireless devices or entities operatively disposed in wireless communication, e.g., a printer, scanner, desktop and/or portable computer, portable data assistant, communications satellite, any piece of equipment or location associated with a wirelessly detectable tag (e.g., a kiosk, news stand, restroom), and telephone.", "This can comprise Wireless Fidelity (Wi-Fi) and BLUETOOTH® wireless technologies.", "Thus, the communication can be a predefined structure as with a conventional network or simply an ad hoc communication between at least two devices.", "Wi-Fi can allow connection to the Internet from a couch at home, a bed in a hotel room or a conference room at work, without wires.", "Wi-Fi is a wireless technology similar to that used in a cell phone that enables such devices, e.g., computers, to send and receive data indoors and out; anywhere within the range of a base station.", "Wi-Fi networks use radio technologies called IEEE 802.11 (a, b, g, n, ac, ag etc.)", "to provide secure, reliable, fast wireless connectivity.", "A Wi-Fi network can be used to connect computers to each other, to the Internet, and to wired networks (which can use IEEE 802.3 or Ethernet).", "Wi-Fi networks operate in the unlicensed 2.4 and 5 GHz radio bands for example or with products that contain both bands (dual band), so the networks can provide real-world performance similar to the basic 10BaseT wired Ethernet networks used in many offices.", "FIG.", "22 presents an example embodiment 2200 of a mobile network platform 2210 that can implement and exploit one or more aspects of the disclosed subject matter described herein.", "In one or more embodiments, the mobile network platform 2210 can generate and receive signals transmitted and received by base stations (e.g., base station devices 1504, macrocell site 1502, or base stations 1614), central office (e.g., central office 1501 or 1611),or transmission device 101 or 102 associated with the disclosed subject matter.", "Generally, wireless network platform 2210 can comprise components, e.g., nodes, gateways, interfaces, servers, or disparate platforms, that facilitate both packet-switched (PS) (e.g., internet protocol (IP), frame relay, asynchronous transfer mode (ATM)) and circuit-switched (CS) traffic (e.g., voice and data), as well as control generation for networked wireless telecommunication.", "As a non-limiting example, wireless network platform 2210 can be included in telecommunications carrier networks, and can be considered carrier-side components as discussed elsewhere herein.", "Mobile network platform 2210 comprises CS gateway node(s) 2222 which can interface CS traffic received from legacy networks like telephony network(s) 2240 (e.g., public switched telephone network (PSTN), or public land mobile network (PLMN)) or a signaling system #7 (SS7) network 2270.Circuit switched gateway node(s) 2222 can authorize and authenticate traffic (e.g., voice) arising from such networks.", "Additionally, CS gateway node(s) 2222 can access mobility, or roaming, data generated through SS7 network 2270; for instance, mobility data stored in a visited location register (VLR), which can reside in memory 2230.Moreover, CS gateway node(s) 2222 interfaces CS-based traffic and signaling and PS gateway node(s) 2218.As an example, in a 3GPP UMTS network, CS gateway node(s) 2222 can be realized at least in part in gateway GPRS support node(s) (GGSN).", "It should be appreciated that functionality and specific operation of CS gateway node(s) 2222, PS gateway node(s) 2218, and serving node(s) 2216, is provided and dictated by radio technology(ies) utilized by mobile network platform 2210 for telecommunication.", "In addition to receiving and processing CS-switched traffic and signaling, PS gateway node(s) 2218 can authorize and authenticate PS-based data sessions with served mobile devices.", "Data sessions can comprise traffic, or content(s), exchanged with networks external to the wireless network platform 2210, like wide area network(s) (WANs) 2250, enterprise network(s) 2270, and service network(s) 2280, which can be embodied in local area network(s) (LANs), can also be interfaced with mobile network platform 2210 through PS gateway node(s) 2218.It is to be noted that WANs 2250 and enterprise network(s) 2260 can embody, at least in part, a service network(s) like IP multimedia subsystem (IMS).", "Based on radio technology layer(s) available in technology resource(s) 2217, packet-switched gateway node(s) 2218 can generate packet data protocol contexts when a data session is established; other data structures that facilitate routing of packetized data also can be generated.", "To that end, in an aspect, PS gateway node(s) 2218 can comprise a tunnel interface (e.g., tunnel termination gateway (TTG) in 3GPP UMTS network(s) (not shown)) which can facilitate packetized communication with disparate wireless network(s), such as Wi-Fi networks.", "In embodiment 2200, wireless network platform 2210 also comprises serving node(s) 2216 that, based upon available radio technology layer(s) within technology resource(s) 2217, convey the various packetized flows of data streams received through PS gateway node(s) 2218.It is to be noted that for technology resource(s) 2217 that rely primarily on CS communication, server node(s) can deliver traffic without reliance on PS gateway node(s) 2218; for example, server node(s) can embody at least in part a mobile switching center.", "As an example, in a 3GPP UMTS network, serving node(s) 2216 can be embodied in serving GPRS support node(s) (SGSN).", "For radio technologies that exploit packetized communication, server(s) 2214 in wireless network platform 2210 can execute numerous applications that can generate multiple disparate packetized data streams or flows, and manage (e.g., schedule, queue, format .", ".", ". )", "such flows.", "Such application(s) can comprise add-on features to standard services (for example, provisioning, billing, customer support .", ".", ". )", "provided by wireless network platform 2210.Data streams (e.g., content(s) that are part of a voice call or data session) can be conveyed to PS gateway node(s) 2218 for authorization/authentication and initiation of a data session, and to serving node(s) 2216 for communication thereafter.", "In addition to application server, server(s) 2214 can comprise utility server(s), a utility server can comprise a provisioning server, an operations and maintenance server, a security server that can implement at least in part a certificate authority and firewalls as well as other security mechanisms, and the like.", "In an aspect, security server(s) secure communication served through wireless network platform 2210 to ensure network's operation and data integrity in addition to authorization and authentication procedures that CS gateway node(s) 2222 and PS gateway node(s) 2218 can enact.", "Moreover, provisioning server(s) can provision services from external network(s) like networks operated by a disparate service provider; for instance, WAN 2250 or Global Positioning System (GPS) network(s) (not shown).", "Provisioning server(s) can also provision coverage through networks associated to wireless network platform 2210 (e.g., deployed and operated by the same service provider), such as the distributed antennas networks shown in FIG.", "1(s) that enhance wireless service coverage by providing more network coverage.", "Repeater devices such as those shown in FIGS.", "7, 8, and 9 also improve network coverage in order to enhance subscriber service experience by way of UE 2275.It is to be noted that server(s) 2214 can comprise one or more processors configured to confer at least in part the functionality of macro network platform 2210.To that end, the one or more processor can execute code instructions stored in memory 2230, for example.", "It is should be appreciated that server(s) 2214 can comprise a content manager 2215, which operates in substantially the same manner as described hereinbefore.", "In example embodiment 2200, memory 2230 can store information related to operation of wireless network platform 2210.Other operational information can comprise provisioning information of mobile devices served through wireless platform network 2210, subscriber databases; application intelligence, pricing schemes, e.g., promotional rates, flat-rate programs, couponing campaigns; technical specification(s) consistent with telecommunication protocols for operation of disparate radio, or wireless, technology layers; and so forth.", "Memory 2230 can also store information from at least one of telephony network(s) 2240, WAN 2250, enterprise network(s) 2270, or SS7 network 2260.In an aspect, memory 2230 can be, for example, accessed as part of a data store component or as a remotely connected memory store.", "In order to provide a context for the various aspects of the disclosed subject matter, FIG.", "22, and the following discussion, are intended to provide a brief, general description of a suitable environment in which the various aspects of the disclosed subject matter can be implemented.", "While the subject matter has been described above in the general context of computer-executable instructions of a computer program that runs on a computer and/or computers, those skilled in the art will recognize that the disclosed subject matter also can be implemented in combination with other program modules.", "Generally, program modules comprise routines, programs, components, data structures, etc.", "that perform particular tasks and/or implement particular abstract data types.", "FIG.", "23 depicts an illustrative embodiment of a communication device 2300.The communication device 2300 can serve as an illustrative embodiment of devices such as mobile devices and in-building devices referred to by the subject disclosure (e.g., in FIGS.", "15, 16A and 16B).", "The communication device 2300 can comprise a wireline and/or wireless transceiver 2302 (herein transceiver 2302), a user interface (UI) 2304, a power supply 2314, a location receiver 2316, a motion sensor 2318, an orientation sensor 2320, and a controller 2306 for managing operations thereof.", "The transceiver 2302 can support short-range or long-range wireless access technologies such as Bluetooth®, ZigBee®, WiFi, DECT, or cellular communication technologies, just to mention a few (Bluetooth® and ZigBee® are trademarks registered by the Bluetooth® Special Interest Group and the ZigBee® Alliance, respectively).", "Cellular technologies can include, for example, CDMA-1×, UMTS/HSDPA, GSM/GPRS, TDMA/EDGE, EV/DO, WiMAX, SDR, LTE, as well as other next generation wireless communication technologies as they arise.", "The transceiver 2302 can also be adapted to support circuit-switched wireline access technologies (such as PSTN), packet-switched wireline access technologies (such as TCP/IP, VoIP, etc.", "), and combinations thereof.", "The UI 2304 can include a depressible or touch-sensitive keypad 2308 with a navigation mechanism such as a roller ball, a joystick, a mouse, or a navigation disk for manipulating operations of the communication device 2300.The keypad 2308 can be an integral part of a housing assembly of the communication device 2300 or an independent device operably coupled thereto by a tethered wireline interface (such as a USB cable) or a wireless interface supporting for example Bluetooth®.", "The keypad 2308 can represent a numeric keypad commonly used by phones, and/or a QWERTY keypad with alphanumeric keys.", "The UI 2304 can further include a display 2310 such as monochrome or color LCD (Liquid Crystal Display), OLED (Organic Light Emitting Diode) or other suitable display technology for conveying images to an end user of the communication device 2300.In an embodiment where the display 2310 is touch-sensitive, a portion or all of the keypad 2308 can be presented by way of the display 2310 with navigation features.", "The display 2310 can use touch screen technology to also serve as a user interface for detecting user input.", "As a touch screen display, the communication device 2300 can be adapted to present a user interface having graphical user interface (GUI) elements that can be selected by a user with a touch of a finger.", "The touch screen display 2310 can be equipped with capacitive, resistive or other forms of sensing technology to detect how much surface area of a user's finger has been placed on a portion of the touch screen display.", "This sensing information can be used to control the manipulation of the GUI elements or other functions of the user interface.", "The display 2310 can be an integral part of the housing assembly of the communication device 2300 or an independent device communicatively coupled thereto by a tethered wireline interface (such as a cable) or a wireless interface.", "The UI 2304 can also include an audio system 2312 that utilizes audio technology for conveying low volume audio (such as audio heard in proximity of a human ear) and high volume audio (such as speakerphone for hands free operation).", "The audio system 2312 can further include a microphone for receiving audible signals of an end user.", "The audio system 2312 can also be used for voice recognition applications.", "The UI 2304 can further include an image sensor 2313 such as a charged coupled device (CCD) camera for capturing still or moving images.", "The power supply 2314 can utilize common power management technologies such as replaceable and rechargeable batteries, supply regulation technologies, and/or charging system technologies for supplying energy to the components of the communication device 2300 to facilitate long-range or short-range portable communications.", "Alternatively, or in combination, the charging system can utilize external power sources such as DC power supplied over a physical interface such as a USB port or other suitable tethering technologies.", "The location receiver 2316 can utilize location technology such as a global positioning system (GPS) receiver capable of assisted GPS for identifying a location of the communication device 2300 based on signals generated by a constellation of GPS satellites, which can be used for facilitating location services such as navigation.", "The motion sensor 2318 can utilize motion sensing technology such as an accelerometer, a gyroscope, or other suitable motion sensing technology to detect motion of the communication device 2300 in three-dimensional space.", "The orientation sensor 2320 can utilize orientation sensing technology such as a magnetometer to detect the orientation of the communication device 2300 (north, south, west, and east, as well as combined orientations in degrees, minutes, or other suitable orientation metrics).", "The communication device 2300 can use the transceiver 2302 to also determine a proximity to a cellular, WiFi, Bluetooth®, or other wireless access points by sensing techniques such as utilizing a received signal strength indicator (RSSI) and/or signal time of arrival (TOA) or time of flight (TOF) measurements.", "The controller 2306 can utilize computing technologies such as a microprocessor, a digital signal processor (DSP), programmable gate arrays, application specific integrated circuits, and/or a video processor with associated storage memory such as Flash, ROM, RAM, SRAM, DRAM or other storage technologies for executing computer instructions, controlling, and processing data supplied by the aforementioned components of the communication device 2300.Other components not shown in FIG.", "23 can be used in one or more embodiments of the subject disclosure.", "For instance, the communication device 2300 can include a slot for adding or removing an identity module such as a Subscriber Identity Module (SIM) card or Universal Integrated Circuit Card (UICC).", "SIM or UICC cards can be used for identifying subscriber services, executing programs, storing subscriber data, and so on.", "In the subject specification, terms such as “store,” “storage,” “data store,” data storage,” “database,” and substantially any other information storage component relevant to operation and functionality of a component, refer to “memory components,” or entities embodied in a “memory” or components comprising the memory.", "It will be appreciated that the memory components described herein can be either volatile memory or nonvolatile memory, or can comprise both volatile and nonvolatile memory, by way of illustration, and not limitation, volatile memory, non-volatile memory, disk storage, and memory storage.", "Further, nonvolatile memory can be included in read only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable ROM (EEPROM), or flash memory.", "Volatile memory can comprise random access memory (RAM), which acts as external cache memory.", "By way of illustration and not limitation, RAM is available in many forms such as synchronous RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double data rate SDRAM (DDR SDRAM), enhanced SDRAM (ESDRAM), Synchlink DRAM (SLDRAM), and direct Rambus RAM (DRRAM).", "Additionally, the disclosed memory components of systems or methods herein are intended to comprise, without being limited to comprising, these and any other suitable types of memory.", "Moreover, it will be noted that the disclosed subject matter can be practiced with other computer system configurations, comprising single-processor or multiprocessor computer systems, mini-computing devices, mainframe computers, as well as personal computers, hand-held computing devices (e.g., PDA, phone, smartphone, watch, tablet computers, netbook computers, etc.", "), microprocessor-based or programmable consumer or industrial electronics, and the like.", "The illustrated aspects can also be practiced in distributed computing environments where tasks are performed by remote processing devices that are linked through a communications network; however, some if not all aspects of the subject disclosure can be practiced on stand-alone computers.", "In a distributed computing environment, program modules can be located in both local and remote memory storage devices.", "Some of the embodiments described herein can also employ artificial intelligence (AI) to facilitate automating one or more features described herein.", "For example, artificial intelligence can be used in optional training controller 230 evaluate and select candidate frequencies, modulation schemes, MIMO modes, and/or guided wave modes in order to maximize transfer efficiency.", "The embodiments (e.g., in connection with automatically identifying acquired cell sites that provide a maximum value/benefit after addition to an existing communication network) can employ various AI-based schemes for carrying out various embodiments thereof.", "Moreover, the classifier can be employed to determine a ranking or priority of the each cell site of the acquired network.", "A classifier is a function that maps an input attribute vector, x=(x1, x2, x3, x4, .", ".", ".", ", xn), to a confidence that the input belongs to a class, that is, f(x)=confidence (class).", "Such classification can employ a probabilistic and/or statistical-based analysis (e.g., factoring into the analysis utilities and costs) to prognose or infer an action that a user desires to be automatically performed.", "A support vector machine (SVM) is an example of a classifier that can be employed.", "The SVM operates by finding a hypersurface in the space of possible inputs, which the hypersurface attempts to split the triggering criteria from the non-triggering events.", "Intuitively, this makes the classification correct for testing data that is near, but not identical to training data.", "Other directed and undirected model classification approaches comprise, e.g., naïve Bayes, Bayesian networks, decision trees, neural networks, fuzzy logic models, and probabilistic classification models providing different patterns of independence can be employed.", "Classification as used herein also is inclusive of statistical regression that is utilized to develop models of priority.", "As will be readily appreciated, one or more of the embodiments can employ classifiers that are explicitly trained (e.g., via a generic training data) as well as implicitly trained (e.g., via observing UE behavior, operator preferences, historical information, receiving extrinsic information).", "For example, SVMs can be configured via a learning or training phase within a classifier constructor and feature selection module.", "Thus, the classifier(s) can be used to automatically learn and perform a number of functions, including but not limited to determining according to a predetermined criteria which of the acquired cell sites will benefit a maximum number of subscribers and/or which of the acquired cell sites will add minimum value to the existing communication network coverage, etc.", "As used in some contexts in this application, in some embodiments, the terms “component,” “system” and the like are intended to refer to, or comprise, a computer-related entity or an entity related to an operational apparatus with one or more specific functionalities, wherein the entity can be either hardware, a combination of hardware and software, software, or software in execution.", "As an example, a component may be, but is not limited to being, a process running on a processor, a processor, an object, an executable, a thread of execution, computer-executable instructions, a program, and/or a computer.", "By way of illustration and not limitation, both an application running on a server and the server can be a component.", "One or more components may reside within a process and/or thread of execution and a component may be localized on one computer and/or distributed between two or more computers.", "In addition, these components can execute from various computer readable media having various data structures stored thereon.", "The components may communicate via local and/or remote processes such as in accordance with a signal having one or more data packets (e.g., data from one component interacting with another component in a local system, distributed system, and/or across a network such as the Internet with other systems via the signal).", "As another example, a component can be an apparatus with specific functionality provided by mechanical parts operated by electric or electronic circuitry, which is operated by a software or firmware application executed by a processor, wherein the processor can be internal or external to the apparatus and executes at least a part of the software or firmware application.", "As yet another example, a component can be an apparatus that provides specific functionality through electronic components without mechanical parts, the electronic components can comprise a processor therein to execute software or firmware that confers at least in part the functionality of the electronic components.", "While various components have been illustrated as separate components, it will be appreciated that multiple components can be implemented as a single component, or a single component can be implemented as multiple components, without departing from example embodiments.", "Further, the various embodiments can be implemented as a method, apparatus or article of manufacture using standard programming and/or engineering techniques to produce software, firmware, hardware or any combination thereof to control a computer to implement the disclosed subject matter.", "The term “article of manufacture” as used herein is intended to encompass a computer program accessible from any computer-readable device or computer-readable storage/communications media.", "For example, computer readable storage media can include, but are not limited to, magnetic storage devices (e.g., hard disk, floppy disk, magnetic strips), optical disks (e.g., compact disk (CD), digital versatile disk (DVD)), smart cards, and flash memory devices (e.g., card, stick, key drive).", "Of course, those skilled in the art will recognize many modifications can be made to this configuration without departing from the scope or spirit of the various embodiments.", "In addition, the words “example” and “exemplary” are used herein to mean serving as an instance or illustration.", "Any embodiment or design described herein as “example” or “exemplary” is not necessarily to be construed as preferred or advantageous over other embodiments or designs.", "Rather, use of the word example or exemplary is intended to present concepts in a concrete fashion.", "As used in this application, the term “or” is intended to mean an inclusive “or” rather than an exclusive “or”.", "That is, unless specified otherwise or clear from context, “X employs A or B” is intended to mean any of the natural inclusive permutations.", "That is, if X employs A; X employs B; or X employs both A and B, then “X employs A or B” is satisfied under any of the foregoing instances.", "In addition, the articles “a” and “an” as used in this application and the appended claims should generally be construed to mean “one or more” unless specified otherwise or clear from context to be directed to a singular form.", "Moreover, terms such as “user equipment,” “mobile station,” “mobile,” subscriber station,” “access terminal,” “terminal,” “handset,” “mobile device” (and/or terms representing similar terminology) can refer to a wireless device utilized by a subscriber or user of a wireless communication service to receive or convey data, control, voice, video, sound, gaming or substantially any data-stream or signaling-stream.", "The foregoing terms are utilized interchangeably herein and with reference to the related drawings.", "Furthermore, the terms “user,” “subscriber,” “customer,” “consumer” and the like are employed interchangeably throughout, unless context warrants particular distinctions among the terms.", "It should be appreciated that such terms can refer to human entities or automated components supported through artificial intelligence (e.g., a capacity to make inference based, at least, on complex mathematical formalisms), which can provide simulated vision, sound recognition and so forth.", "As employed herein, the term “processor” can refer to substantially any computing processing unit or device comprising, but not limited to comprising, single-core processors; single-processors with software multithread execution capability; multi-core processors; multi-core processors with software multithread execution capability; multi-core processors with hardware multithread technology; parallel platforms; and parallel platforms with distributed shared memory.", "Additionally, a processor can refer to an integrated circuit, an application specific integrated circuit (ASIC), a digital signal processor (DSP), a field programmable gate array (FPGA), a programmable logic controller (PLC), a complex programmable logic device (CPLD), a discrete gate or transistor logic, discrete hardware components or any combination thereof designed to perform the functions described herein.", "Processors can exploit nano-scale architectures such as, but not limited to, molecular and quantum-dot based transistors, switches and gates, in order to optimize space usage or enhance performance of user equipment.", "A processor can also be implemented as a combination of computing processing units.", "As used herein, terms such as “data storage,” data storage,” “database,” and substantially any other information storage component relevant to operation and functionality of a component, refer to “memory components,” or entities embodied in a “memory” or components comprising the memory.", "It will be appreciated that the memory components or computer-readable storage media, described herein can be either volatile memory or nonvolatile memory or can include both volatile and nonvolatile memory.", "What has been described above includes mere examples of various embodiments.", "It is, of course, not possible to describe every conceivable combination of components or methodologies for purposes of describing these examples, but one of ordinary skill in the art can recognize that many further combinations and permutations of the present embodiments are possible.", "Accordingly, the embodiments disclosed and/or claimed herein are intended to embrace all such alterations, modifications and variations that fall within the spirit and scope of the appended claims.", "Furthermore, to the extent that the term “includes” is used in either the detailed description or the claims, such term is intended to be inclusive in a manner similar to the term “comprising” as “comprising” is interpreted when employed as a transitional word in a claim.", "In addition, a flow diagram may include a “start” and/or “continue” indication.", "The “start” and “continue” indications reflect that the steps presented can optionally be incorporated in or otherwise used in conjunction with other routines.", "In this context, “start” indicates the beginning of the first step presented and may be preceded by other activities not specifically shown.", "Further, the “continue” indication reflects that the steps presented may be performed multiple times and/or may be succeeded by other activities not specifically shown.", "Further, while a flow diagram indicates a particular ordering of steps, other orderings are likewise possible provided that the principles of causality are maintained.", "As may also be used herein, the term(s) “operably coupled to”, “coupled to”, and/or “coupling” includes direct coupling between items and/or indirect coupling between items via one or more intervening items.", "Such items and intervening items include, but are not limited to, junctions, communication paths, components, circuit elements, circuits, functional blocks, and/or devices.", "As an example of indirect coupling, a signal conveyed from a first item to a second item may be modified by one or more intervening items by modifying the form, nature or format of information in a signal, while one or more elements of the information in the signal are nevertheless conveyed in a manner than can be recognized by the second item.", "In a further example of indirect coupling, an action in a first item can cause a reaction on the second item, as a result of actions and/or reactions in one or more intervening items.", "Although specific embodiments have been illustrated and described herein, it should be appreciated that any arrangement which achieves the same or similar purpose may be substituted for the embodiments described or shown by the subject disclosure.", "The subject disclosure is intended to cover any and all adaptations or variations of various embodiments.", "Combinations of the above embodiments, and other embodiments not specifically described herein, can be used in the subject disclosure.", "For instance, one or more features from one or more embodiments can be combined with one or more features of one or more other embodiments.", "In one or more embodiments, features that are positively recited can also be negatively recited and excluded from the embodiment with or without replacement by another structural and/or functional feature.", "The steps or functions described with respect to the embodiments of the subject disclosure can be performed in any order.", "The steps or functions described with respect to the embodiments of the subject disclosure can be performed alone or in combination with other steps or functions of the subject disclosure, as well as from other embodiments or from other steps that have not been described in the subject disclosure.", "Further, more than or less than all of the features described with respect to an embodiment can also be utilized." ] ]
Patent_15872643
[ [ "METHODS AND COMPOSITIONS FOR TREATMENT OF A GENETIC CONDITION", "Methods and compositions comprising single guide RNAs targeted to endogenous gene for genetic alteration of cells are provided." ], [ "1.A CRISPR/Cas nuclease comprising two single guide RNAs (sgRNA) that bind to target sites in a T cell receptor (TCR) gene and/or human leukocyte (HLA) gene; each comprising a cleavage domain, wherein the nuclease cleaves and inactivates the TCR or HLA gene.", "2.The nuclease of claim 1, wherein the TCR gene is a T-cell receptor alpha (TRAC) gene or a T-cell receptor beta (TRBC) gene.", "3.The nuclease of claim 1, wherein the HLA gene is an HLA-A gene, an HLA B gene, an HLA C gene, an HLA-DPA gene, an HLA-DQ gene, an HLA-DRA gene and/or a beta-2 microglobulin gene.", "4.The nuclease of claim 1, wherein the cleavage domain comprises a Type IIS restriction enzyme nuclease domain or a Cas protein.", "5.A mammalian cell comprising the nuclease of claim 1.6.The mammalian cell of claim 5, wherein the mammalian cell is a stem cell.", "7.The mammalian cell of claim 6, wherein the stem cell is a hematopoietic stem cell.", "8.The mammalian cell of claim 5, further comprising a transgene encoding a chimeric antigen receptor (CAR).", "9.The mammalian cell of claim 5, further wherein one or more additional genes are inactivated in the cell.", "10.The mammalian cell of claim 9, wherein the one or more additional inactivated genes comprise a PD1 gene, a CTLA-4 gene, a Tap1 gene, a Tap2 gene, a tapasin gene, a CIITA gene and/or an RFX5 gene.", "11.A method of inactivating an endogenous TCR and/or HLA gene in a cell, the method comprising the steps of: administering to the cell one or more CRISPR/Cas nucleases according to claim 1, wherein the nucleases cleave and inactivates the TCR and/or HLA genes.", "12.The method of claim 11, comprising a Type IIS restriction enzyme nuclease domain or a Cas protein.", "13.The method of claim 11, wherein the cell is a mammalian cell.", "14.The method of claim 13, wherein the mammalian cell is a stem cell.", "15.The method of claim 14, wherein the stem cell is a hematopoietic stem cell.", "16.The method of claim 11, further comprising integrating one or more CAR transgenes into the cell.", "17.A cell made by method of claim 11.18.A method of treating a disorder in a subject in need thereof, the method comprising inactivated TCR and/or HLA expression in a cell of the subject according to the method of claim 11.19.The method of claim 18, wherein the disorder is a cancer.", "20.The method of claim 18, wherein the cell is stem cell.", "21.The method of claim 20, wherein the stem cell is a hematopoietic stem cell." ], [ "<SOH> BACKGROUND <EOH>Gene therapy holds enormous potential for a new era in human medicine.", "These methodologies will allow treatment for conditions that heretofore have not been addressable by standard medical practice.", "One area that is especially promising is the ability to genetically engineer a cell to cause that cell to express a product that has not previously been produced in that cell.", "Examples of uses of this technology include the insertion of a transgene encoding a novel therapeutic protein, insertion of a coding sequence encoding a protein that is lacking in the cell or in the individual, insertion of a wild type gene in a cell containing a mutated gene sequence, and insertion of a sequence that encodes a structural nucleic acid such as a microRNA or siRNA.", "To meet the challenge of increasing global demand for food production, many effective approaches to improving agricultural productivity (e.g.", "enhanced yield or engineered pest resistance) rely on either mutation breeding or introduction of novel genes into the genomes of crop species by transformation.", "Both processes are inherently non-specific and relatively inefficient.", "For example, conventional plant transformation methods deliver exogenous DNA that integrates into the genome at random locations.", "The random nature of these methods makes it necessary to generate and screen hundreds of unique random-integration events per construct in order to identify and isolate transgenic lines with desirable attributes.", "Moreover, conventional transformation methods create several challenges for transgene evaluation including: (a) difficulty for predicting whether pleiotropic effects due to unintended genome disruption have occurred; and (b) difficulty for comparing the impact of different regulatory elements and transgene designs within a single transgene candidate, because such comparisons are complicated by random integration into the genome.", "As a result, conventional plant trait engineering is a laborious and cost intensive process with a low probability of success.", "Precision gene modification overcomes the logistical challenges of conventional practices in plant systems, and as such has been a longstanding but elusive goal in both basic plant biology research and agricultural biotechnology.", "However, with the exception of “gene targeting” via positive-negative drug selection in rice or the use of pre-engineered restriction sites, targeted genome modification in all plant species, both model and crop, has until recently proven very difficult.", "Terada et al., (2002) Nat Biotechnol 20(10):1030; Terada et al., (2007) Plant Physiol 144(2):846; D'Halluin et al., (2008) Plant Biotechnology J.", "6(1):93.Transgene (or trait) stacking has great potential for production of plants, but has proven difficult.", "See, e.g., Halpin (2005) Plant Biotechnology Journal 3:141-155.In addition, polyploidy, where the organism has two or more duplicated (autoploidy) or related (alloploid) paired sets of chromosomes, occurs more often in plant species than in animals.", "For example, wheat has lines that are diploid (two sets of chromosomes), tetraploid (four sets of chromosomes) and hexaploid (six sets of chromosomes).", "In addition, many agriculturally important plants of the genus Brassica are also allotetraploids.", "Transgenes can be delivered to a cell by a variety of ways, such that the transgene becomes integrated into the cell's own genome and is maintained there.", "In recent years, a strategy for transgene integration has been developed that uses cleavage with site-specific nucleases for targeted insertion into a chosen genomic locus (see, e.g., co-owned U.S. Pat.", "No.", "7,888,121).", "Nucleases specific for targeted genes can be utilized such that the transgene construct is inserted by either homology directed repair (HDR) or by end capture during non-homologous end joining (NHEJ) driven processes.", "Targeted loci include “safe harbor” loci such as the AAVS1, HPRT and CCR5 genes in human cells, and Rosa26 in murine cells (see, e.g., U.S. Pat.", "Nos.", "7,888,121; 7,972,854; 7,914,796; 7,951,925; 8,110,379; 8,409,861; 8,586,526; U.S. Patent Publication Nos.", "2003/0232410; 2005/0208489; 2005/0026157; 2006/0063231; 2008/0159996; 2010/00218264; 2012/0017290; 2011/0265198; 2013/0137104; 2013/0122591; 2013/0177983; and 2013/0177960) and the Zp15 locus in plants (see U.S. Pat.", "No.", "8,329,986).", "Nuclease-mediated integration offers the prospect of improved transgene expression, increased safety and expressional durability, as compared to classic integration approaches that rely on random integration of the transgene, since it allows exact transgene positioning for a minimal risk of gene silencing or activation of nearby oncogenes.", "Genome engineering can also include the knocking out of genes in addition to insertion methods described above.", "In the absence of a donor nucleic acid, a cell with a cleaved genome will resort to the error prone NHEJ pathway to heal the break.", "This process often adds or deletes nucleotides during the repair process (“indels”) which may lead to the introduction of missense or non-sense mutations at the target site.", "For example, CCR5-specific zinc finger nucleases are being used in Phase I/II trials to create a non-functional CCR5 receptor, and thus prevent HIV infection (see U.S. Pat.", "No.", "7,951,925).", "Targeted nuclease-mediated genome cleavage at a desired location can be obtained by the use of an engineered nuclease.", "For example, a double-strand break (DSB) for can be created by a site-specific nuclease such as a zinc-finger nuclease (ZFN) or TAL effector domain nuclease (TALEN).", "See, for example, Urnov et al., (2010) Nature 435(7042):646-51; U.S. Pat.", "Nos.", "8,586,526; 6,534,261; 6,599,692; 6,503,717; 6,689,558; 7,067,317; and 7,262,054, the disclosures of which are incorporated by reference in their entireties for all purposes.", "Another nuclease system involves the use of a so-called acquired immunity system found in bacteria and archaea known as the CRISPR/Cas system.", "CRISPR/Cas systems are found in 40% of bacteria and 90% of archaea and differ in the complexities of their systems.", "See, e.g., U.S. Pat.", "No.", "8,697,359.The CRISPR loci (clustered regularly interspaced short palindromic repeat) is a region within the organism's genome where short segments of foreign DNA are integrated between short repeat palindromic sequences.", "These loci are transcribed and the RNA transcripts (“pre-crRNA”) are processed into short CRISPR RNAs (crRNAs).", "There are three types of CRISPR/Cas systems which all incorporate these RNAs and proteins known as “Cas” proteins (CRISPR associated).", "Types I and III both have Cas endonucleases that process the pre-crRNAs, that, when fully processed into crRNAs, assemble a multi-Cas protein complex that is capable of cleaving nucleic acids that are complementary to the crRNA.", "In type II systems, crRNAs are produced using a different mechanism where a trans-activating RNA (tracrRNA) complementary to repeat sequences in the pre-crRNA, triggers processing by a double strand-specific RNase III in the presence of the Cas9 protein.", "Cas9 is then able to cleave a target DNA that is complementary to the mature crRNA however cleavage by Cas 9 is dependent both upon base-pairing between the crRNA and the target DNA, and on the presence of a short motif in the crRNA referred to as the PAM sequence (protospacer adjacent motif) (see Qi et al., (2013) Cell 152:1173).", "In addition, the tracrRNA must also be present as it base pairs with the crRNA at its 3′ end, and this association triggers Cas9 activity.", "The Cas9 protein has at least two nuclease domains: one nuclease domain is similar to a HNH endonuclease, while the other resembles a Ruv endonuclease domain.", "The HNH-type domain appears to be responsible for cleaving the DNA strand that is complementary to the crRNA while the Ruv domain cleaves the non-complementary strand.", "The requirement of the crRNA-tracrRNA complex can be avoided by use of an engineered “single-guide RNA” (sgRNA) that comprises the hairpin normally formed by the annealing of the crRNA and the tracrRNA (see Jinek et al., (2012) Science 337:816 and Cong et al., (2013) Sciencexpress/ 10.1126/science.1231143).", "In S. pyrogenes , the engineered tracrRNA:crRNA fusion, or the sgRNA, guides Cas9 to cleave the target DNA when a double strand RNA:DNA heterodimer forms between the Cas associated RNAs and the target DNA.", "This system comprising the Cas9 protein and an engineered sgRNA containing a PAM sequence has been used for RNA guided genome editing (see Ramalingam et al., (2013) Stem Cells and Development 22(4):595-610) and has been useful for zebrafish embryo genomic editing in vivo (see Hwang et al., (2013) Nature Biotechnology 31 (3):227) with editing efficiencies similar to ZFNs and TALENs.", "Thus, there remains a need for systems for genomic editing, including for treatment and/or prevention of diseases and for agricultural uses." ], [ "<SOH> SUMMARY <EOH>Disclosed herein are methods and compositions for genetic modification, for example for the treatment of a disease or for production of genetically modified plants.", "Genome editing is used to correct an aberrant gene, insert a wild type gene, or change the expression of an endogenous gene.", "One or more endogenous genes can be targeted for genomic editing, including any mammalian or plant gene(s).", "By way of non-limiting example, a wild-type gene encoding β globin may be inserted into the genome of a cell to treat a hemoglobinopathy caused by faulty β globin.", "In some instances, the wild type gene may be inserted into a safe harbor locus or at a locus known to be highly expressed in a tissue of interest such as the β globin locus in erythroid cells.", "Another approach disclosed here involves the use of gene correction where a faulty endogenous gene is targeted and the mutant sequence replaced using an engineered donor (e.g., the mutant is replaced with a functional sequence).", "Alternately, one or more regulatory genes involved in the modulation of another gene may be altered, for example a regulatory gene involved in repression of a gene may be altered or knocked out such that the normally repressed gene is now expressed or not expressed, or the regulatory binding site upstream of the a gene or in other areas of the locus are altered so that the regulators are not able to interact properly with the DNA at the gene locus and regulate gene expression.", "Another approach further involves the use of modified stem cells (e.g., hematopoietic stem cell or red blood cell (RBC) precursor), which can then be used to engraft into a patient, for treatment of a hemoglobinopathy or other disease (e.g., genetic disease).", "In one aspect, described herein is a CRISPR/Cas system that binds to target site in a region of interest in an endogenous gene (e.g., an endogenous or safe harbor gene, or a regulatory gene or its DNA target) in a genome, wherein the CRISPR/Cas system comprises one or more engineered single guide RNAs that recognize the target gene and a functional domain (e.g., a transcriptional regulatory domain and/or a nuclease domain).", "The CRISPR/Cas system as described herein may bind to and/or cleave the region of interest in a coding or non-coding region within or adjacent to the gene, such as, for example, a leader sequence, trailer sequence or intron, or within a non-transcribed region, either upstream or downstream of the coding region.", "In certain embodiments, the CRISPR/Cas binds to and/or cleaves a gene.", "In other embodiments, the CRISPR/Cas binds to and/or cleaves a safe-harbor gene, for example a CCR5 gene, a PPP1R12C (also known as AAVS1) gene, or a Rosa gene in mammalian cells, and the Zp15 locus in plants.", "PPP1R12C has 22 exons in its coding sequence, and an especially preferred location for targeting is within intron 1 (i.e.", "at or near chr19:55624164-55624759), enabling the insertion of a promoter-less transgene.", "In addition, to aid in selection in mammalian systems, the HPRT locus may be used (see U.S. Patent Publication Nos.", "2013/0137104 and 2013/0122591).", "In some embodiments, the CRISPR/Cas binds to and cleaves at regulatory elements.", "In another aspect, described herein are compositions comprising one or more of the CRISPR/Cas nucleases as described herein.", "In one aspect, the CRISPR/Cas system as described may bind to and/or modulate expression of a gene of interest.", "In one embodiment, the CRISPR/Cas system binds to a DNA sequence and prevents binding of other regulatory factors.", "In another embodiment, the binding of a CRISPR/Cas system fusion protein may modulate (i.e.", "induce or repress) expression of a target DNA.", "In another aspect, described is a polynucleotide encoding one or more CRISPR/Cas system described herein.", "The polynucleotide may be, for example, mRNA.", "In some aspects, the mRNA may be chemically modified (See e.g.", "Kormann et al., (2011) Nature Biotechnology 29(2): 154-157).", "In another aspect, described is a CRISPR/Cas system expression vector comprising a polynucleotide encoding one or more CRISPR/Cas components described herein, operably linked to a promoter.", "In one embodiment, the expression vector is a viral vector.", "In another embodiment, the expression vector is a DNA minicircle.", "In one aspect, described herein is a Cas protein that is used to cleave a target DNA.", "In another aspect, described herein is a method of modifying an endogenous gene (e.g., modulating expression of the endogenous gene), the method comprising administering to the cell a first nucleic acid molecule comprising a single guide RNA that recognizes a target site in the endogenous gene and a second nucleic acid molecule that encodes a functional domain, wherein the functional domain associates with the single guide RNA on the target site, thereby modifying the endogenous gene.", "The first and second nucleic acids may be on the same or different vectors.", "In certain embodiments, the endogenous gene is selected from the group consisting of a mammalian globin gene (HBB), a gamma globin gene (HBG1), a B-cell lymphoma/leukemia 11A (BCL11A) gene, a Kruppel-like factor 1 (KLF1) gene, a CCR5 gene, a CXCR4 gene, a PPP1R12C (AAVS1) gene, an hypoxanthine phosphoribosyltransferase (HPRT) gene, an albumin gene, a Factor VIII gene, a Factor IX gene, a Leucine-rich repeat kinase 2 (LRRK2) gene, a Hungtingin (Htt) gene, a rhodopsin (RHO) gene, a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, a surfactant protein B gene (SFTPB), a T-cell receptor alpha (TRAC) gene, a T-cell receptor beta (TRBC) gene, a programmed cell death 1 (PD1) gene, a Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) gene, an human leukocyte antigen (HLA) A gene, an HLA B gene, an HLA C gene, an HLA-DPA gene, an HLA-DQ gene, an HLA-DRA gene, a LMP7 gene, a Transporter associated with Antigen Processing (TAP) 1 gene, a TAP2 gene, a tapasin gene (TAPBP), a class II major histocompatibility complex transactivator (CIITA) gene, a dystrophin gene (DMD), a glucocorticoid receptor gene (GR), an IL2RG gene, an RFX5 gene, a FAD2 gene, a FAD3 gene, a ZP15 gene, a KASII gene, a MDH gene, and/or an EPSPS gene.", "In any of the methods and compositions described herein, the cell can be any eukaryotic cell(s), for example a plant cell or a mammalian cell or cell line, including COS, CHO (e.g., CHO-S, CHO-K1, CHO-DG44, CHO-DUXB11, CHO-DUKX, CHOK1SV), VERO, MDCK, WI38, V79, B14AF28-G3, BHK, HaK, NS0, SP2/0-Ag14, HeLa, HEK293 (e.g., HEK293-F, HEK293-H, HEK293-T), and perC6 cells as well as insect cells such as Spodoptera fugiperda (Sf), or fungal cells such as Saccharomyces, Pichia and Schizosaccharomyces .", "In certain embodiments, the cell line is a CHO, MDCK or HEK293 cell line.", "Primary cells can also be edited as described herein, including but not limited to fibroblasts, blood cells (e.g., red blood cells, white blood cells), liver cells, kidney cells, neural cells, and the like.", "Suitable cells also include stem cells such as, by way of example, embryonic stem cells, induced pluripotent stem cells (iPSCs), hematopoietic stem cells, neuronal stem cells and mesenchymal stem cells.", "In other aspects, genetically modified blood cell precursors (hematopoietic stem cells known as “HSCs”) are given in a bone marrow transplant and the HSCs differentiate and mature in vivo.", "In other aspects, genetically modified RBC precursors and/or hematopoietic stem cells (HSCs) are given in a bone marrow transplant and the RBCs differentiate and mature in vivo.", "In some embodiments, the HSCs are isolated from the peripheral blood following G-CSF-induced mobilization, and in others, the cells are isolated from human bone marrow or umbilical cord blood.", "In some aspects, the HSCs are edited by treatment with a nuclease designed to knock out a specific gene or regulatory sequence.", "In other aspects, the HSCs are modified with an engineered nuclease and a donor nucleic acid such that a wild type gene is inserted and expressed and/or an endogenous aberrant gene is corrected.", "In some embodiments, an engineered gene is inserted and expressed.", "In some embodiments, the modified HSCs are administered to the patient following mild myeloablative pre-conditioning.", "In other aspects, the HSCs are administered after full myeloablation such that following engraftment, a majority of the hematopoietic cells are derived from the newly engrafted modified HSC population.", "In one aspect, the invention comprises mutated Cas nucleases.", "In some embodiments, the mutant Cas nucleases are Cas9 nucleases, and have altered functionality.", "In some embodiments, the Cas9 protein is mutated in the HNH domain, rendering it unable to cleave the DNA strand that is complementary to the crRNA.", "In other embodiments, the Cas9 is mutated in the Rvu domain, making it incapable of cleaving the non-complimentary DNA strand.", "These mutations can result in the creation of Cas9 nickases.", "In some embodiments, two Cas nickases are used with two separate crRNAs to target a DNA, which results in two nicks in the target DNA at a specified distance apart.", "In other embodiments, both the HNH and Rvu endonuclease domains are altered to render a Cas9 protein which is unable to cleave a target DNA.", "In another aspect, the methods and compositions of the invention comprise truncations of the Cas9 protein.", "In one embodiment, the Cas9 protein is truncated such that one or more of the Cas9 functional domains are removed.", "In one embodiment, the removal of part or one of the nuclease domains renders the Cas nuclease a nickase.", "In one embodiment, the Cas9 comprises only the domain responsible for interaction with the crRNA or sgRNA and the target DNA.", "In still further aspects, the methods and compositions of the invention also comprise fusion proteins wherein the Cas9 protein, or truncation thereof, is fused to a functional domain.", "In some aspects, the functional domain is an activation or a repression domain.", "In other aspects, the functional domain is a nuclease domain.", "In some embodiments, the nuclease domain is a FokI endonuclease domain (e.g.", "Tsai (2014) Nature Biotech doi:10.1038/nbt.2908).", "In some embodiments, the FokI domain comprises mutations in the dimerization domain.", "In another aspect, described herein is a method for inserting a sequence into an endogenous gene (e.g., safe harbor gene) in a cell (e.g.", "stem cell), the method comprising cleaving the endogenous gene using one or more nucleases and inserting a sequence into the cleavage site.", "In certain embodiments, a genomic sequence in any target gene is replaced, for example using a CRISPR/Cas system (or vector encoding said CRIPSR/Cas system) as described herein and a “donor” sequence (also known as a “transgene”) that is inserted into the gene following targeted cleavage.", "The donor sequence may be present in the CRISPR/Cas vector, present in a separate vector (e.g., Ad, AAV, DNA minicircle or LV vector) or, alternatively, may be introduced into the cell using a different nucleic acid delivery mechanism.", "For example, mRNA encoding the Cas nuclease protein may be introduced into a cell with the desired sgRNA by electroporation.", "Such insertion of a donor nucleotide sequence into the target locus (e.g., safe-harbor gene) results in the expression of the transgene under control of the target locus's genetic control elements.", "In some embodiments, the transgene encodes a non-coding RNA (e.g.", "an shRNA).", "Expression of the transgene prior to stem cell differentiation will result in a derivative cell containing the non-coding RNA of interest.", "In some embodiments, the methods and compositions of the invention are performed in and/or comprise plant cells.", "In some aspects, the plant cells are meristematic cells.", "In some embodiments, the plant cells comprise a nuclease of the invention.", "In other embodiments, the plant cells additionally comprise a transgene.", "In yet another aspect, described herein is a method for introducing one or more exogenous sequence into the genome of a plant cell, the method comprising the steps of: (a) contacting the cell with the one or more exogenous sequences (donor vector, transgene or GOI); and (b) expressing one or more nucleases (e.g., CRISPR/Cas system) as described herein in the cell, wherein the one or more nucleases cleave chromosomal DNA; such that cleavage of chromosomal DNA in step (b) stimulates incorporation of the donor vector into the genome by homologous recombination.", "Multiple transgenes may be integrated simultaneously (in parallel) or the steps may be repeated for sequential addition of transgenes (transgene stacking).", "In other embodiments, the transgene comprises a functional protein, for example a globin (e.g., wild type beta and/or wild type gamma) protein.", "In other embodiments, the transgene encodes an engineered gene for production of a novel protein with desirable qualities.", "In some embodiments, insertion of the transgene of interest into an endogenous gene, results in expression of an intact exogenous protein sequence and lacks any sequences encoded by the endogenous gene.", "In other embodiments, the expressed exogenous protein is a fusion protein and comprises amino acids encoded by the transgene and by the endogenous gene (e.g., from the endogenous target locus).", "When present, endogenous sequences may be present on the amino (N)-terminal portion of the exogenous protein and/or the carboxy (C)-terminal portion of the exogenous protein.", "In some aspects, the safe harbor is selected from the AAVS1, Rosa, HPRT, Zp15 or CCR5 locus (see U.S. Patent Publications Nos.", "2008/0299580; 2008/0159996; 2010/00218264; 2013/0137104; and 2013/0122591 and U.S. Pat.", "No.", "8,329,986).", "In yet another aspect, provided herein are genomically modified cell lines and/or transgenic organisms such as animal models (systems).", "In some embodiments, the transgenic cell and/or organism (e.g., animal) includes a transgene that encodes a human gene.", "In some instances, the transgenic animal comprises a knock out at the endogenous locus corresponding to exogenous transgene, thereby allowing the development of an in vivo system where the human protein may be studied in isolation.", "Such transgenic models may be used for screening purposes to identify small molecules or large biomolecules or other entities which may interact with or modify the human protein of interest.", "In some embodiments, the cell lines of the invention are used in cell-based assays for activity screens in pharmaceutical development, while in other embodiments, the cell lines are used in diagnostic assays.", "In some aspects, the transgene is integrated into the selected locus (e.g., safe-harbor) into a stem cell (e.g., an embryonic stem cell, an induced pluripotent stem cell, a hematopoietic stem cell, etc.)", "or animal embryo obtained by any of the methods described herein, and then the embryo is implanted such that a live animal is born.", "The animal is then raised to sexual maturity and allowed to produce offspring wherein at least some of the offspring comprise edited endogenous gene sequence or the integrated transgene.", "In a still further aspect, a cell (e.g., plant or mammalian cell) obtained according to any of the methods described herein is also provided.", "In another aspect, provided herein is an organism (e.g., plant or animal) comprising a cell (e.g., plant or animal) as described herein.", "In another aspect, provided herein is a seed from a plant comprising the plant cell that is obtained as described herein.", "In another aspect, provided herein is fruit obtained from a plant comprising plant cell obtained as described herein.", "In any of the compositions (cells or plants) or methods described herein, the plant cell can comprise a monocotyledonous or dicotyledonous plant cell.", "In certain embodiments, the plant cell is a crop plant, for example, wheat, tomato (or other fruit crop), potato, maize, soy, alfalfa, etc.", "In a still further aspect, provided herein is a method for site-specific integration of a nucleic acid sequence into an endogenous locus (e.g., safe harbor gene) of a chromosome, for example into the chromosome of an embryo.", "In certain embodiments, the method comprises: (a) injecting an embryo with (i) at least one DNA vector, wherein the DNA vector comprises an upstream sequence and a downstream sequence flanking the nucleic acid sequence to be integrated, and (ii) at least one RNA molecule encoding a CRISPR/Cas system nuclease that recognizes the site of integration in the target locus (e.g., globin or safe harbor locus), and (b) culturing the embryo to allow expression of the CRISPR/Cas system nuclease, wherein a double stranded break introduced into the site of integration by the CRISPR/Cas system nuclease is repaired, via homologous recombination with the DNA vector, so as to integrate the nucleic acid sequence into the chromosome.", "In any of the methods described herein, the polynucleotide encoding the CRISPR/Cas system can comprise DNA, RNA or combinations thereof.", "In certain embodiments, the polynucleotide comprises a plasmid.", "In other embodiments, the polynucleotide encoding the nuclease comprises mRNA.", "A kit, comprising a CRISPR/Cas system of the invention, is also provided.", "The kit may comprise nucleic acids encoding a CRISPR/Cas system, (e.g.", "RNA molecules or CRISPR/Cas system encoding genes contained in a suitable expression vector), or aliquots of the nuclease proteins, donor molecules, suitable host cell lines, instructions for performing the methods of the invention, and the like.", "These and other aspects will be readily apparent to the skilled artisan in light of disclosure as a whole.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS The application is a continuation application of U.S. patent application Ser.", "No.", "14/965,629, filed Dec. 10, 2015, which is a continuation of U.S. patent application Ser.", "No.", "14/278,903, filed May 15, 2014, now U.S. Pat.", "No.", "9,873,894, which claims the benefit of U.S.", "Provisional Application No.", "61/823,689, filed May 15, 2013, the disclosures of which are hereby incorporated by reference in their entireties.", "SEQUENCE LISTING The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety.", "Said ASCII copy, created on Jan. 12, 2018, is named 8325010603_SL.txt and is 51,550 bytes in size.", "TECHNICAL FIELD The present disclosure is in the field of genome engineering.", "BACKGROUND Gene therapy holds enormous potential for a new era in human medicine.", "These methodologies will allow treatment for conditions that heretofore have not been addressable by standard medical practice.", "One area that is especially promising is the ability to genetically engineer a cell to cause that cell to express a product that has not previously been produced in that cell.", "Examples of uses of this technology include the insertion of a transgene encoding a novel therapeutic protein, insertion of a coding sequence encoding a protein that is lacking in the cell or in the individual, insertion of a wild type gene in a cell containing a mutated gene sequence, and insertion of a sequence that encodes a structural nucleic acid such as a microRNA or siRNA.", "To meet the challenge of increasing global demand for food production, many effective approaches to improving agricultural productivity (e.g.", "enhanced yield or engineered pest resistance) rely on either mutation breeding or introduction of novel genes into the genomes of crop species by transformation.", "Both processes are inherently non-specific and relatively inefficient.", "For example, conventional plant transformation methods deliver exogenous DNA that integrates into the genome at random locations.", "The random nature of these methods makes it necessary to generate and screen hundreds of unique random-integration events per construct in order to identify and isolate transgenic lines with desirable attributes.", "Moreover, conventional transformation methods create several challenges for transgene evaluation including: (a) difficulty for predicting whether pleiotropic effects due to unintended genome disruption have occurred; and (b) difficulty for comparing the impact of different regulatory elements and transgene designs within a single transgene candidate, because such comparisons are complicated by random integration into the genome.", "As a result, conventional plant trait engineering is a laborious and cost intensive process with a low probability of success.", "Precision gene modification overcomes the logistical challenges of conventional practices in plant systems, and as such has been a longstanding but elusive goal in both basic plant biology research and agricultural biotechnology.", "However, with the exception of “gene targeting” via positive-negative drug selection in rice or the use of pre-engineered restriction sites, targeted genome modification in all plant species, both model and crop, has until recently proven very difficult.", "Terada et al., (2002) Nat Biotechnol 20(10):1030; Terada et al., (2007) Plant Physiol 144(2):846; D'Halluin et al., (2008) Plant Biotechnology J.", "6(1):93.Transgene (or trait) stacking has great potential for production of plants, but has proven difficult.", "See, e.g., Halpin (2005) Plant Biotechnology Journal 3:141-155.In addition, polyploidy, where the organism has two or more duplicated (autoploidy) or related (alloploid) paired sets of chromosomes, occurs more often in plant species than in animals.", "For example, wheat has lines that are diploid (two sets of chromosomes), tetraploid (four sets of chromosomes) and hexaploid (six sets of chromosomes).", "In addition, many agriculturally important plants of the genus Brassica are also allotetraploids.", "Transgenes can be delivered to a cell by a variety of ways, such that the transgene becomes integrated into the cell's own genome and is maintained there.", "In recent years, a strategy for transgene integration has been developed that uses cleavage with site-specific nucleases for targeted insertion into a chosen genomic locus (see, e.g., co-owned U.S. Pat.", "No.", "7,888,121).", "Nucleases specific for targeted genes can be utilized such that the transgene construct is inserted by either homology directed repair (HDR) or by end capture during non-homologous end joining (NHEJ) driven processes.", "Targeted loci include “safe harbor” loci such as the AAVS1, HPRT and CCR5 genes in human cells, and Rosa26 in murine cells (see, e.g., U.S. Pat.", "Nos.", "7,888,121; 7,972,854; 7,914,796; 7,951,925; 8,110,379; 8,409,861; 8,586,526; U.S. Patent Publication Nos.", "2003/0232410; 2005/0208489; 2005/0026157; 2006/0063231; 2008/0159996; 2010/00218264; 2012/0017290; 2011/0265198; 2013/0137104; 2013/0122591; 2013/0177983; and 2013/0177960) and the Zp15 locus in plants (see U.S. Pat.", "No.", "8,329,986).", "Nuclease-mediated integration offers the prospect of improved transgene expression, increased safety and expressional durability, as compared to classic integration approaches that rely on random integration of the transgene, since it allows exact transgene positioning for a minimal risk of gene silencing or activation of nearby oncogenes.", "Genome engineering can also include the knocking out of genes in addition to insertion methods described above.", "In the absence of a donor nucleic acid, a cell with a cleaved genome will resort to the error prone NHEJ pathway to heal the break.", "This process often adds or deletes nucleotides during the repair process (“indels”) which may lead to the introduction of missense or non-sense mutations at the target site.", "For example, CCR5-specific zinc finger nucleases are being used in Phase I/II trials to create a non-functional CCR5 receptor, and thus prevent HIV infection (see U.S. Pat.", "No.", "7,951,925).", "Targeted nuclease-mediated genome cleavage at a desired location can be obtained by the use of an engineered nuclease.", "For example, a double-strand break (DSB) for can be created by a site-specific nuclease such as a zinc-finger nuclease (ZFN) or TAL effector domain nuclease (TALEN).", "See, for example, Urnov et al., (2010) Nature 435(7042):646-51; U.S. Pat.", "Nos.", "8,586,526; 6,534,261; 6,599,692; 6,503,717; 6,689,558; 7,067,317; and 7,262,054, the disclosures of which are incorporated by reference in their entireties for all purposes.", "Another nuclease system involves the use of a so-called acquired immunity system found in bacteria and archaea known as the CRISPR/Cas system.", "CRISPR/Cas systems are found in 40% of bacteria and 90% of archaea and differ in the complexities of their systems.", "See, e.g., U.S. Pat.", "No.", "8,697,359.The CRISPR loci (clustered regularly interspaced short palindromic repeat) is a region within the organism's genome where short segments of foreign DNA are integrated between short repeat palindromic sequences.", "These loci are transcribed and the RNA transcripts (“pre-crRNA”) are processed into short CRISPR RNAs (crRNAs).", "There are three types of CRISPR/Cas systems which all incorporate these RNAs and proteins known as “Cas” proteins (CRISPR associated).", "Types I and III both have Cas endonucleases that process the pre-crRNAs, that, when fully processed into crRNAs, assemble a multi-Cas protein complex that is capable of cleaving nucleic acids that are complementary to the crRNA.", "In type II systems, crRNAs are produced using a different mechanism where a trans-activating RNA (tracrRNA) complementary to repeat sequences in the pre-crRNA, triggers processing by a double strand-specific RNase III in the presence of the Cas9 protein.", "Cas9 is then able to cleave a target DNA that is complementary to the mature crRNA however cleavage by Cas 9 is dependent both upon base-pairing between the crRNA and the target DNA, and on the presence of a short motif in the crRNA referred to as the PAM sequence (protospacer adjacent motif) (see Qi et al., (2013) Cell 152:1173).", "In addition, the tracrRNA must also be present as it base pairs with the crRNA at its 3′ end, and this association triggers Cas9 activity.", "The Cas9 protein has at least two nuclease domains: one nuclease domain is similar to a HNH endonuclease, while the other resembles a Ruv endonuclease domain.", "The HNH-type domain appears to be responsible for cleaving the DNA strand that is complementary to the crRNA while the Ruv domain cleaves the non-complementary strand.", "The requirement of the crRNA-tracrRNA complex can be avoided by use of an engineered “single-guide RNA” (sgRNA) that comprises the hairpin normally formed by the annealing of the crRNA and the tracrRNA (see Jinek et al., (2012) Science 337:816 and Cong et al., (2013) Sciencexpress/10.1126/science.1231143).", "In S. pyrogenes, the engineered tracrRNA:crRNA fusion, or the sgRNA, guides Cas9 to cleave the target DNA when a double strand RNA:DNA heterodimer forms between the Cas associated RNAs and the target DNA.", "This system comprising the Cas9 protein and an engineered sgRNA containing a PAM sequence has been used for RNA guided genome editing (see Ramalingam et al., (2013) Stem Cells and Development 22(4):595-610) and has been useful for zebrafish embryo genomic editing in vivo (see Hwang et al., (2013) Nature Biotechnology 31 (3):227) with editing efficiencies similar to ZFNs and TALENs.", "Thus, there remains a need for systems for genomic editing, including for treatment and/or prevention of diseases and for agricultural uses.", "SUMMARY Disclosed herein are methods and compositions for genetic modification, for example for the treatment of a disease or for production of genetically modified plants.", "Genome editing is used to correct an aberrant gene, insert a wild type gene, or change the expression of an endogenous gene.", "One or more endogenous genes can be targeted for genomic editing, including any mammalian or plant gene(s).", "By way of non-limiting example, a wild-type gene encoding β globin may be inserted into the genome of a cell to treat a hemoglobinopathy caused by faulty β globin.", "In some instances, the wild type gene may be inserted into a safe harbor locus or at a locus known to be highly expressed in a tissue of interest such as the β globin locus in erythroid cells.", "Another approach disclosed here involves the use of gene correction where a faulty endogenous gene is targeted and the mutant sequence replaced using an engineered donor (e.g., the mutant is replaced with a functional sequence).", "Alternately, one or more regulatory genes involved in the modulation of another gene may be altered, for example a regulatory gene involved in repression of a gene may be altered or knocked out such that the normally repressed gene is now expressed or not expressed, or the regulatory binding site upstream of the a gene or in other areas of the locus are altered so that the regulators are not able to interact properly with the DNA at the gene locus and regulate gene expression.", "Another approach further involves the use of modified stem cells (e.g., hematopoietic stem cell or red blood cell (RBC) precursor), which can then be used to engraft into a patient, for treatment of a hemoglobinopathy or other disease (e.g., genetic disease).", "In one aspect, described herein is a CRISPR/Cas system that binds to target site in a region of interest in an endogenous gene (e.g., an endogenous or safe harbor gene, or a regulatory gene or its DNA target) in a genome, wherein the CRISPR/Cas system comprises one or more engineered single guide RNAs that recognize the target gene and a functional domain (e.g., a transcriptional regulatory domain and/or a nuclease domain).", "The CRISPR/Cas system as described herein may bind to and/or cleave the region of interest in a coding or non-coding region within or adjacent to the gene, such as, for example, a leader sequence, trailer sequence or intron, or within a non-transcribed region, either upstream or downstream of the coding region.", "In certain embodiments, the CRISPR/Cas binds to and/or cleaves a gene.", "In other embodiments, the CRISPR/Cas binds to and/or cleaves a safe-harbor gene, for example a CCR5 gene, a PPP1R12C (also known as AAVS1) gene, or a Rosa gene in mammalian cells, and the Zp15 locus in plants.", "PPP1R12C has 22 exons in its coding sequence, and an especially preferred location for targeting is within intron 1 (i.e.", "at or near chr19:55624164-55624759), enabling the insertion of a promoter-less transgene.", "In addition, to aid in selection in mammalian systems, the HPRT locus may be used (see U.S. Patent Publication Nos.", "2013/0137104 and 2013/0122591).", "In some embodiments, the CRISPR/Cas binds to and cleaves at regulatory elements.", "In another aspect, described herein are compositions comprising one or more of the CRISPR/Cas nucleases as described herein.", "In one aspect, the CRISPR/Cas system as described may bind to and/or modulate expression of a gene of interest.", "In one embodiment, the CRISPR/Cas system binds to a DNA sequence and prevents binding of other regulatory factors.", "In another embodiment, the binding of a CRISPR/Cas system fusion protein may modulate (i.e.", "induce or repress) expression of a target DNA.", "In another aspect, described is a polynucleotide encoding one or more CRISPR/Cas system described herein.", "The polynucleotide may be, for example, mRNA.", "In some aspects, the mRNA may be chemically modified (See e.g.", "Kormann et al., (2011) Nature Biotechnology 29(2): 154-157).", "In another aspect, described is a CRISPR/Cas system expression vector comprising a polynucleotide encoding one or more CRISPR/Cas components described herein, operably linked to a promoter.", "In one embodiment, the expression vector is a viral vector.", "In another embodiment, the expression vector is a DNA minicircle.", "In one aspect, described herein is a Cas protein that is used to cleave a target DNA.", "In another aspect, described herein is a method of modifying an endogenous gene (e.g., modulating expression of the endogenous gene), the method comprising administering to the cell a first nucleic acid molecule comprising a single guide RNA that recognizes a target site in the endogenous gene and a second nucleic acid molecule that encodes a functional domain, wherein the functional domain associates with the single guide RNA on the target site, thereby modifying the endogenous gene.", "The first and second nucleic acids may be on the same or different vectors.", "In certain embodiments, the endogenous gene is selected from the group consisting of a mammalian globin gene (HBB), a gamma globin gene (HBG1), a B-cell lymphoma/leukemia 11A (BCL11A) gene, a Kruppel-like factor 1 (KLF1) gene, a CCR5 gene, a CXCR4 gene, a PPP1R12C (AAVS1) gene, an hypoxanthine phosphoribosyltransferase (HPRT) gene, an albumin gene, a Factor VIII gene, a Factor IX gene, a Leucine-rich repeat kinase 2 (LRRK2) gene, a Hungtingin (Htt) gene, a rhodopsin (RHO) gene, a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, a surfactant protein B gene (SFTPB), a T-cell receptor alpha (TRAC) gene, a T-cell receptor beta (TRBC) gene, a programmed cell death 1 (PD1) gene, a Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) gene, an human leukocyte antigen (HLA) A gene, an HLA B gene, an HLA C gene, an HLA-DPA gene, an HLA-DQ gene, an HLA-DRA gene, a LMP7 gene, a Transporter associated with Antigen Processing (TAP) 1 gene, a TAP2 gene, a tapasin gene (TAPBP), a class II major histocompatibility complex transactivator (CIITA) gene, a dystrophin gene (DMD), a glucocorticoid receptor gene (GR), an IL2RG gene, an RFX5 gene, a FAD2 gene, a FAD3 gene, a ZP15 gene, a KASII gene, a MDH gene, and/or an EPSPS gene.", "In any of the methods and compositions described herein, the cell can be any eukaryotic cell(s), for example a plant cell or a mammalian cell or cell line, including COS, CHO (e.g., CHO-S, CHO-K1, CHO-DG44, CHO-DUXB11, CHO-DUKX, CHOK1SV), VERO, MDCK, WI38, V79, B14AF28-G3, BHK, HaK, NS0, SP2/0-Ag14, HeLa, HEK293 (e.g., HEK293-F, HEK293-H, HEK293-T), and perC6 cells as well as insect cells such as Spodoptera fugiperda (Sf), or fungal cells such as Saccharomyces, Pichia and Schizosaccharomyces.", "In certain embodiments, the cell line is a CHO, MDCK or HEK293 cell line.", "Primary cells can also be edited as described herein, including but not limited to fibroblasts, blood cells (e.g., red blood cells, white blood cells), liver cells, kidney cells, neural cells, and the like.", "Suitable cells also include stem cells such as, by way of example, embryonic stem cells, induced pluripotent stem cells (iPSCs), hematopoietic stem cells, neuronal stem cells and mesenchymal stem cells.", "In other aspects, genetically modified blood cell precursors (hematopoietic stem cells known as “HSCs”) are given in a bone marrow transplant and the HSCs differentiate and mature in vivo.", "In other aspects, genetically modified RBC precursors and/or hematopoietic stem cells (HSCs) are given in a bone marrow transplant and the RBCs differentiate and mature in vivo.", "In some embodiments, the HSCs are isolated from the peripheral blood following G-CSF-induced mobilization, and in others, the cells are isolated from human bone marrow or umbilical cord blood.", "In some aspects, the HSCs are edited by treatment with a nuclease designed to knock out a specific gene or regulatory sequence.", "In other aspects, the HSCs are modified with an engineered nuclease and a donor nucleic acid such that a wild type gene is inserted and expressed and/or an endogenous aberrant gene is corrected.", "In some embodiments, an engineered gene is inserted and expressed.", "In some embodiments, the modified HSCs are administered to the patient following mild myeloablative pre-conditioning.", "In other aspects, the HSCs are administered after full myeloablation such that following engraftment, a majority of the hematopoietic cells are derived from the newly engrafted modified HSC population.", "In one aspect, the invention comprises mutated Cas nucleases.", "In some embodiments, the mutant Cas nucleases are Cas9 nucleases, and have altered functionality.", "In some embodiments, the Cas9 protein is mutated in the HNH domain, rendering it unable to cleave the DNA strand that is complementary to the crRNA.", "In other embodiments, the Cas9 is mutated in the Rvu domain, making it incapable of cleaving the non-complimentary DNA strand.", "These mutations can result in the creation of Cas9 nickases.", "In some embodiments, two Cas nickases are used with two separate crRNAs to target a DNA, which results in two nicks in the target DNA at a specified distance apart.", "In other embodiments, both the HNH and Rvu endonuclease domains are altered to render a Cas9 protein which is unable to cleave a target DNA.", "In another aspect, the methods and compositions of the invention comprise truncations of the Cas9 protein.", "In one embodiment, the Cas9 protein is truncated such that one or more of the Cas9 functional domains are removed.", "In one embodiment, the removal of part or one of the nuclease domains renders the Cas nuclease a nickase.", "In one embodiment, the Cas9 comprises only the domain responsible for interaction with the crRNA or sgRNA and the target DNA.", "In still further aspects, the methods and compositions of the invention also comprise fusion proteins wherein the Cas9 protein, or truncation thereof, is fused to a functional domain.", "In some aspects, the functional domain is an activation or a repression domain.", "In other aspects, the functional domain is a nuclease domain.", "In some embodiments, the nuclease domain is a FokI endonuclease domain (e.g.", "Tsai (2014) Nature Biotech doi:10.1038/nbt.2908).", "In some embodiments, the FokI domain comprises mutations in the dimerization domain.", "In another aspect, described herein is a method for inserting a sequence into an endogenous gene (e.g., safe harbor gene) in a cell (e.g.", "stem cell), the method comprising cleaving the endogenous gene using one or more nucleases and inserting a sequence into the cleavage site.", "In certain embodiments, a genomic sequence in any target gene is replaced, for example using a CRISPR/Cas system (or vector encoding said CRIPSR/Cas system) as described herein and a “donor” sequence (also known as a “transgene”) that is inserted into the gene following targeted cleavage.", "The donor sequence may be present in the CRISPR/Cas vector, present in a separate vector (e.g., Ad, AAV, DNA minicircle or LV vector) or, alternatively, may be introduced into the cell using a different nucleic acid delivery mechanism.", "For example, mRNA encoding the Cas nuclease protein may be introduced into a cell with the desired sgRNA by electroporation.", "Such insertion of a donor nucleotide sequence into the target locus (e.g., safe-harbor gene) results in the expression of the transgene under control of the target locus's genetic control elements.", "In some embodiments, the transgene encodes a non-coding RNA (e.g.", "an shRNA).", "Expression of the transgene prior to stem cell differentiation will result in a derivative cell containing the non-coding RNA of interest.", "In some embodiments, the methods and compositions of the invention are performed in and/or comprise plant cells.", "In some aspects, the plant cells are meristematic cells.", "In some embodiments, the plant cells comprise a nuclease of the invention.", "In other embodiments, the plant cells additionally comprise a transgene.", "In yet another aspect, described herein is a method for introducing one or more exogenous sequence into the genome of a plant cell, the method comprising the steps of: (a) contacting the cell with the one or more exogenous sequences (donor vector, transgene or GOI); and (b) expressing one or more nucleases (e.g., CRISPR/Cas system) as described herein in the cell, wherein the one or more nucleases cleave chromosomal DNA; such that cleavage of chromosomal DNA in step (b) stimulates incorporation of the donor vector into the genome by homologous recombination.", "Multiple transgenes may be integrated simultaneously (in parallel) or the steps may be repeated for sequential addition of transgenes (transgene stacking).", "In other embodiments, the transgene comprises a functional protein, for example a globin (e.g., wild type beta and/or wild type gamma) protein.", "In other embodiments, the transgene encodes an engineered gene for production of a novel protein with desirable qualities.", "In some embodiments, insertion of the transgene of interest into an endogenous gene, results in expression of an intact exogenous protein sequence and lacks any sequences encoded by the endogenous gene.", "In other embodiments, the expressed exogenous protein is a fusion protein and comprises amino acids encoded by the transgene and by the endogenous gene (e.g., from the endogenous target locus).", "When present, endogenous sequences may be present on the amino (N)-terminal portion of the exogenous protein and/or the carboxy (C)-terminal portion of the exogenous protein.", "In some aspects, the safe harbor is selected from the AAVS1, Rosa, HPRT, Zp15 or CCR5 locus (see U.S. Patent Publications Nos.", "2008/0299580; 2008/0159996; 2010/00218264; 2013/0137104; and 2013/0122591 and U.S. Pat.", "No.", "8,329,986).", "In yet another aspect, provided herein are genomically modified cell lines and/or transgenic organisms such as animal models (systems).", "In some embodiments, the transgenic cell and/or organism (e.g., animal) includes a transgene that encodes a human gene.", "In some instances, the transgenic animal comprises a knock out at the endogenous locus corresponding to exogenous transgene, thereby allowing the development of an in vivo system where the human protein may be studied in isolation.", "Such transgenic models may be used for screening purposes to identify small molecules or large biomolecules or other entities which may interact with or modify the human protein of interest.", "In some embodiments, the cell lines of the invention are used in cell-based assays for activity screens in pharmaceutical development, while in other embodiments, the cell lines are used in diagnostic assays.", "In some aspects, the transgene is integrated into the selected locus (e.g., safe-harbor) into a stem cell (e.g., an embryonic stem cell, an induced pluripotent stem cell, a hematopoietic stem cell, etc.)", "or animal embryo obtained by any of the methods described herein, and then the embryo is implanted such that a live animal is born.", "The animal is then raised to sexual maturity and allowed to produce offspring wherein at least some of the offspring comprise edited endogenous gene sequence or the integrated transgene.", "In a still further aspect, a cell (e.g., plant or mammalian cell) obtained according to any of the methods described herein is also provided.", "In another aspect, provided herein is an organism (e.g., plant or animal) comprising a cell (e.g., plant or animal) as described herein.", "In another aspect, provided herein is a seed from a plant comprising the plant cell that is obtained as described herein.", "In another aspect, provided herein is fruit obtained from a plant comprising plant cell obtained as described herein.", "In any of the compositions (cells or plants) or methods described herein, the plant cell can comprise a monocotyledonous or dicotyledonous plant cell.", "In certain embodiments, the plant cell is a crop plant, for example, wheat, tomato (or other fruit crop), potato, maize, soy, alfalfa, etc.", "In a still further aspect, provided herein is a method for site-specific integration of a nucleic acid sequence into an endogenous locus (e.g., safe harbor gene) of a chromosome, for example into the chromosome of an embryo.", "In certain embodiments, the method comprises: (a) injecting an embryo with (i) at least one DNA vector, wherein the DNA vector comprises an upstream sequence and a downstream sequence flanking the nucleic acid sequence to be integrated, and (ii) at least one RNA molecule encoding a CRISPR/Cas system nuclease that recognizes the site of integration in the target locus (e.g., globin or safe harbor locus), and (b) culturing the embryo to allow expression of the CRISPR/Cas system nuclease, wherein a double stranded break introduced into the site of integration by the CRISPR/Cas system nuclease is repaired, via homologous recombination with the DNA vector, so as to integrate the nucleic acid sequence into the chromosome.", "In any of the methods described herein, the polynucleotide encoding the CRISPR/Cas system can comprise DNA, RNA or combinations thereof.", "In certain embodiments, the polynucleotide comprises a plasmid.", "In other embodiments, the polynucleotide encoding the nuclease comprises mRNA.", "A kit, comprising a CRISPR/Cas system of the invention, is also provided.", "The kit may comprise nucleic acids encoding a CRISPR/Cas system, (e.g.", "RNA molecules or CRISPR/Cas system encoding genes contained in a suitable expression vector), or aliquots of the nuclease proteins, donor molecules, suitable host cell lines, instructions for performing the methods of the invention, and the like.", "These and other aspects will be readily apparent to the skilled artisan in light of disclosure as a whole.", "DETAILED DESCRIPTION Disclosed herein are methods and compositions for genome engineering, including genome engineering to study and treat a disease or for the creation of a plant with desirable traits.", "The invention describes genomic editing of any target cell such that there is a favorable change in the expression of one or more genes, which in turn results in treatment of a disease in a subject in need thereof or the production of a desirable plant.", "Non-limiting examples of diseases include genetic diseases (e.g., hemoglobinopathies, hemophilia, lysosomal storage diseases, cystic fibrosis etc.", "), infectious diseases (e.g., HIV), neurological diseases (e.g., PD, HD, etc.", "), cancers, and the like.", "Additionally, delivery of altered stem cells in a transplant altered to express a desired protein product can be similarly beneficial in a disease.", "Also described are cell lines and organisms (e.g., plants or animals) with altered gene expression.", "Described below are genes to be targeted by the CRISPR/Cas system using the sgRNAs of the invention.", "Mammalian gene locations as described are relative to the UCSC Genome Brower created by the Genome Bioinformatics Group of UC Santa Cruz, software copyright the Regents of the University of California.", "Human genomic coordinates are provided in the GRCh37/hg19 assembly of the human genome, and correspond to numbers on a double stranded DNA.", "Thus, any position described by a genomic coordinate corresponds to either the (+) or Watson strand, or may specify its corresponding (−) or Crick strand.", "Exemplary targets include genes involved in hemoglobinopathies.", "Hemoglobin is a heterotetramer comprising two α-like globin chains and two β-like globin chains and 4 heme groups.", "In adults the α2β2 tetramer is referred to as Hemoglobin A (HbA) or adult hemoglobin.", "Typically, the alpha and beta globin chains are synthesized in an approximate 1:1 ratio and this ratio seems to be critical in terms of hemoglobin and RBC stabilization.", "In fact, in some cases where one type of the globin genes is inadequately expressed (see below), reducing expression (e.g.", "using a specific siRNA) of the other type of globin, restoring this 1:1 ratio, alleviates some aspects of the mutant cellular phenotype (see Voon et al., (2008) Haematologica 93(8):1288).", "In a developing fetus, a different form of hemoglobin, fetal hemoglobin (HbF) is produced which has a higher binding affinity for oxygen than Hemoglobin A such that oxygen can be delivered to the baby's system via the mother's blood stream.", "Fetal hemoglobin also contains two α globin chains, but in place of the adult β-globin chains, it has two fetal γ-globin chains (α2γ2).", "At approximately 30 weeks of gestation, the synthesis of γ-globin in the fetus starts to drop while the production of β-globin increases.", "By approximately 10 months of age, the newborn's hemoglobin is nearly all α2β2 although some HbF persists into adulthood (approximately 1-3% of total hemoglobin).", "The regulation of the switch from production of γ to β is quite complex, and primarily involves an expressional down-regulation of γ-globin with a simultaneous up-regulation of β-globin expression.", "Genetic defects in the sequences encoding the hemoglobin chains can be responsible for a number of diseases known as hemoglobinopathies, including sickle cell anemia and thalassemias.", "In the majority of patients with hemoglobinopathies, the genes encoding γ-globin remain present, but expression is relatively low due to normal gene repression occurring around parturition as described above.", "It is estimated that 1 in 5000 people in the U.S. have sickle cell disease (SCD), mostly in people of sub-Saharan Africa descent.", "There appears to be a benefit of sickle cell heterozygosity for protection against malaria, so this trait may have been selected for over time, such that it is estimated that in sub-Saharan Africa, one third of the population has the sickle cell trait.", "Sickle cell disease is caused by a mutation in the β-globin gene in which valine is substituted for glutamic acid at amino acid #6 (a GAG to GTG at the DNA level), where the resultant hemoglobin is referred to as “hemoblobin S” or “HbS.” Under lower oxygen conditions, the deoxy form of HbS exposes a hydrophobic patch on the protein between the E and F helices.", "The hydrophobic residues of the valine at position 6 of the beta chain in hemoglobin are able to associate with the hydrophobic patch, causing HbS molecules to aggregate and form fibrous precipitates.", "These aggregates in turn cause the abnormality or ‘sickling’ of the RBCs, resulting in a loss of flexibility of the cells.", "The sickling RBCs are no longer able to squeeze into the capillary beds and can result in vaso-occlusive crisis in sickle cell patients.", "In addition, sickled RBCs are more fragile than normal RBCs, and tend towards hemolysis, eventually leading to anemia in the patient.", "Thalassemias are also diseases relating to hemoglobin and typically involve a reduced expression of globin chains.", "This can occur through mutations in the regulatory regions of the genes or from a mutation in a globin coding sequence that results in reduced expression.", "Alpha thalassemias are associated with people of Western Africa and South Asian descent, and may confer malarial resistance.", "Beta thalassemia is associated with people of Mediterranean descent, typically from Greece and the coastal areas of Turkey and Italy.", "Treatment of thalassemias usually involves blood transfusions and iron chelation therapy.", "Bone marrow transplants are also being used for treatment of people with severe thalassemias if an appropriate donor can be identified, but this procedure can have significant risks.", "Correction of the human HBB gene that encodes beta globin can be accomplished with the CRISPR/Cas system of the invention.", "Preferred locations of cleavage include targeting the HBB gene sequence (i.e.", "at or near chr11:5246696-5248301).", "Especially preferred is to target regions of HBB in a HBS allele to achieve gene correction of a sickle allele.", "Especially preferred for use of a S. pyogenes Cas9 system is targeting sequences where the PAM site is at or near positions on chromosome 11: 5248110, 5248106, 5248100, 5248090, 5248122, 5248112 for correction of a sickle allele.", "For gene correction of a beta-globin allele associated with a beta thalessemia there are many potential targets.", "One well known mutation associated with beta thalassemia is the so-called IVS1.1 mutation, where a preferred targeting region would be around nucleotides 1093-1192 of the HBB gene sequence.", "Most preferred are targeting sequences where the PAM site is at or near positions on chromosome 11: 5248170-5248171, 5248168-5248169, 5248167-5248168, 5248164-5248165, 5248163-5248164, 5248155-5248156 and 5248147-5248148.One approach for the treatment of both SCD and beta thalassemias that has been proposed is to increase the expression of γ-globin with the aim to have HbF functionally replace the aberrant adult hemoglobin.", "As mentioned above, treatment of SCD patients with hydroxyurea is thought to be successful in part due to its effect on increasing γ-globin expression.", "The first group of compounds discovered to affect HbF reactivation activity were cytotoxic drugs.", "The ability to cause de novo synthesis of gamma-globin by pharmacological manipulation was first shown using 5-azacytidine in experimental animals (DeSimone (1982) Proc Natl Acad Sci USA 79(14):4428-31).", "Subsequent studies confirmed the ability of 5-azacytidine to increase HbF in patients with β-thalassemia and sickle cell disease (Ley, et al., (1982) N. Engl.", "J.", "Medicine, 307: 1469-1475, and Ley, et al., (1983) Blood 62: 370-380).", "In addition, short chain fatty acids (e.g.", "butyrate and derivatives) have been shown in experimental systems to increase HbF (Constantoulakis et al., (1988) Blood 72(6):1961-1967).", "There is a segment of the human population with a condition known as ‘Hereditary Persistence of Fetal Hemoglobin’ (HPFH) where elevated amounts of HbF persist in adulthood (10-40% in HPFH heterozygotes (see Thein et al., (2009) Hum.", "Mol.", "Genet 18 (R2): R216-R223)).", "This is a rare condition, but in the absence of any associated beta globin abnormalities, is not associated with any significant clinical manifestations, even when 100% of the individual's hemoglobin is HbF.", "When individuals that have a beta thalassemia also have co-incident HPFH, the expression of HbF can lessen the severity of the disease.", "Further, the severity of the natural course of sickle cell disease can vary significantly from patient to patient, and this variability, in part, can be traced to the fact that some individuals with milder disease express higher levels of HbF.", "One approach to increase the expression of HbF involves identification of genes whose products play a role in the regulation of γ-globin expression.", "One such gene is BCL11A, first identified because of its role in lymphocyte development.", "BCL11A encodes a zinc finger protein that is thought to be involved in the stage specific regulation of γ-globin expression.", "BCL11A is expressed in adult erythroid precursor cells and down-regulation of its expression leads to an increase in γ-globin expression.", "See, Sankaran et al., (2008) Science 322 p. 1839.The protein appears to interact with the β-globin locus to alter its configuration and thus its expression at different developmental stages.", "In addition, another regulatory protein KLF1 (encoded at chr19:12995237-12998017), appears to be involved in regulation of γ-globin expression.", "It has been found that KLF1 levels are directly proportional to BCL11A levels, and both are inversely proportional to γ-globin levels in a Maltese family with persistent expression of HbF that carries a heterozygous mutation of the KLF1 gene (Borg et al., (2011) Haematologica 96(5): 635-638).", "The KLF1 gene product appears to bind directly to the BCL11A gene in vivo, and thus may be responsible for its upregulation (see Borg et al., (2010) Nat Genet 42(9):801-805; Bieker (2010) Nat Genet 42(9): 733-734; Zhou et al., (2010) Nat Genet 42(9):742-744).", "Thus, if KLF1 stimulates BCL11A expression, the action of BCL11A will result in the suppression of γ-globin and HbF production.", "Use of an inhibitory RNA targeted to the BCL11A gene has been proposed (see, e.g., U.S. Patent Publication No.", "2011/0182867) but this technology has several potential drawbacks, namely that complete knock down may not be achieved, delivery of such RNAs may be problematic and the RNAs must be present continuously, requiring multiple treatments for life.", "Thus, the methods and compositions of the invention may be used to treat SCD and hemoglobinopathies with a CRISPR/Cas system where the single guide RNA comprises sequences to target the KLF1 or BCL11a genes.", "Knock out of the KLF1 gene through double strand cleavage may be accomplished through the CRIPSR/Cas system of the invention.", "Preferred sites for targeting are in exon 1, exon 2 and exon 3 to give the desired knock out of the gene.", "Especially preferred are the regions on chromosome 19 at or near 12994239-12999017, 12997868-12998017, and 12996131-12996956.Especially preferred is targeting the region of chromosome 19 at or near 12997877-12997912.Non-limiting examples of sequences suitable for targeting are shown in Table 1.Knock out of the BCL11A gene through double strand cleavage may be accomplished using a CRISPR/Cas system and the sgRNAs of the invention.", "Preferred is to target the BCL11A gene (chr2:60684329-60780633).", "Also preferred is to cleave the BCL11A gene in an exonic sequence (e.g.", "at or near chromosome 2: 60780351-60780633 (exon 1), 60773106-60773435, especially 60773362-60773400 (exon 2), 60695867-60695968 (exon 3), 60687817-60689559 (exon 4), 60678302-60679801 (exon 5)).", "Especially preferred is targeting the enhancer sequence in the BCL11A gene (see Bauer et al., (2013), Science 342 (6155):253-7).", "Thus, targeting sequences at or near chromosome 2 60725317-60725682, 60722125-60722677 and 60718031-60718382 is especially preferred.", "Another approach to alter the expression of gamma globin is to target the regulatory sites on the gene encoding gamma globin (HBG1, located on chromosome 11: 5268501-5272087).", "Preferred is to target the transcriptional start site at or near chromosome 11:5271086-5271087, Especially preferred is to target the so-called “HPFH” region, known because of patients with hereditary persistence of fetal hemoglobin (see Thein et al., (2009) Hum.", "Mol.", "Genet 18 (R2): R216-R223).", "Thus, targeting sequences at or near chromosome 11:5272286-5272290, 5272263-5272263 and 5272198-5272205 is especially preferred.", "Alpha thalassemias are also prevalent in the human population, especially in Asia and some type of alpha globin aberrancy is thought to be the commonest genetic disorder in humans.", "In the tropical and subtropical areas of the world, alpha globin disorder is found in 80-90% of the population (see Harteveld and Higgs (2010) Orphanet Journal of Rare Diseases 5:13).", "Humans carry 2 copies of the alpha globin gene in tandem (α1 and α2) on chromosome 16, so in a normal diploid cell there are 4 copies all together.", "The α2 gene normally accounts for 2-3 times more α-globin mRNA than the α1 gene.", "The tandem organization of these two genes may be associated with the high prevalence of large deletions in alpha globin genes in alpha thalessemia patients, where generally the number of alpha globin genes that are non-functional relates directly to the severity of any alpha thalessemia (see Chui et al., (2003) Blood 101(3):791).", "Deletion of one copy seems to be fairly common (30% of African Americans and 60-80% of people living in Saudi Arabia, India, and Thailand), and is generally not evident in the individual unless genetic testing is done.", "Deletion of two copies, whether on the same chromosome (cis) or one from each chromosome (trans), may cause the afflicted person to have mild anemia.", "When three α-globin genes are deleted, such that the individual has only one functioning α-globin gene, moderate anemia is found, but more importantly, the crucial α globin to β globin ratio is disrupted.", "β4 tetramers, comprising four beta-globin chains, are often observed in patients with only one functional alpha-globin gene, an condition known as HbH.", "The β4 tetramers are able to bind oxygen but do not release it into the periphery, causing what is known as Hb H disease.", "Individuals with HbH disease have RBCs with shortened half-lives and which undergo hemolysis easily, leading to increased anemia.", "Loss of all four α-globin genes is usually fatal in utero.", "Thus, the methods and compositions of the invention may be used to treat thalassemias with a CRISPR/Cas system where the single guide RNA comprises sequences to target the regulatory region of the alpha globin gene.", "Non-limiting examples of sequences suitable for targeting are shown in Table 1.Other exemplary targets include genes encoding receptors, for example viral receptors.", "When HIV infects human T cells, it relies on association with the T cell receptor CD4 and one of two co-receptors, the chemokine receptor CCR5 or CXCR4, to gain entry into the cell.", "Natural CCR5 variants (“CCR5-delta 32”) in the human population were identified who appear to be resistant to HIV infection, especially in the homozygous state.", "Thus, to prevent HIV from infecting T cells, and ultimately leading to T cell death and decreased immune function in the HIV infected patient, disruption of one or both of the co-receptors may be accomplished to render the cell resistant to the virus (see U.S. Pat.", "No.", "7,951,925).", "Currently clinical trials are underway where HIV patient T cells are edited at the CCR5 locus ex vivo to knock out the CCR5 gene.", "These cells are then re-introduced into the patient to treat HIV.", "Thus, the methods and compositions of the invention may be used to disrupt CCR5 alleles with a CRISPR/Cas system where the single guide RNA comprises sequences to target a human CCR5 gene (chr3:46411633-46417697), especially at or near the exon region (chr3:46414394-46415452).", "One especially preferred region for targeting the CCR5 gene for knock out is the region near the delta-32 mutation region (at or near chr3:46414923-46415020).", "Another especially preferred region is around the chr3: 46414522-46414643, which encodes part of the second extracellular loop of the CCR5 protein.", "The region at or near the ATG protein translation initiation site (at or near chr3:46414347-46414466) is also especially preferred for genome modification, such as fusion of a C34 peptide to the N-terminus of CCR5 by targeted integration for anti-HIV therapy.", "Similar studies are in progress in animal models of CXCR4-dependent HIV where the CXCR4 is selectively disrupted, or disrupted in tandem with CCR5 to prevent HIV infection of T cells (see U.S. Patent Publication No.", "2010/0291048).", "Thus, the methods and compositions of the invention may be used to disrupt CXCR4 alleles with a CRISPR/Cas system where the single guide RNA comprises sequences to target a human CXCR4 gene (chr2:136871919-136875725), especially at or near the exon 2 region (chr2:136872439-136873482) and the region surrounding the small exon1 (chr2:136875616-136875630).", "One preferred region for targeting the CXCR4 gene for knock out is the region at or near chr2:136872863-136872982 that is an analog to the delta-32 mutation region in CCR5 gene.", "The region at or near chr2:136875540-136875687 near the ATG protein translation initiation site of exon1 is especially preferred, and the region at or near chr2:136873389-136873558 near the splicing site of exon2 is especially preferred for gene modification, such as fusion of a C34 peptide to the N-terminus of CXCR4 by targeted integration for anti-HIV therapy.", "Thus, a sgRNA can be designed to bind to sequences anywhere in the CCR5 or CXCR4 locus, including, but not limited to, a sequence in one or more of these preferred targeting regions.", "Another receptor of interest is the glucocorticoid receptor (see U.S. Patent Publication No.", "2008/0188000).", "Knock out of this receptor in specific therapeutic treatments allows the use of steroids that are normally taken up by the glucocorticoid receptor.", "Thus, the receptor may be targeted by a CRISPR/Cas system using the sgRNAs of the invention to target at or near chromosome 5: 142646254-142783254.Especially preferred is to target the exonic sequences, for example, at or near chromosome 5 142646255-142783254 (exon 1), 142782776-142783254 (exon 2), 142779221-142780417, and especially useful 142657496-142658976 (exon 3), 142693567-142693733 (exon 4), 142689662-142689778 (exon 5), 142680050-142680328 (exon 6), 142678233-142678377 (exon 7), 142675025-142675155 (exon 8), 142662133-142662290 (exon 9).", "Specific nucleases can also be engineered to insert a peptide fusion inhibitor on to an HIV receptor to prevent HIV infection of T cells (see co-owned US Patent Publication No.", "2012/0093787), where an example of such a peptide fusion inhibitor is C34 or fuzeon.", "Similarly HIV can be treated by using engineered nucleases to insert anti-HIV transgenes in safe harbor loci within the cell to combat the virus.", "Examples of such anti-HIV genes may be selected from the group consisting of a sequence encoding a zinc finger transcription factor that represses an HIV polyprotein, a sequence encoding a zinc finger transcription factor that represses expression of an HIV receptor, a CCR5 ribozyme, an siRNA sequence targeted to an HIV polyprotein, a sequence encoding a Trim5alpha (Trim5a) restriction factor, a sequence encoding an APOBEC3G restriction factor, a sequence encoding a RevM10 protein, a sequence encoding C46, other anti-HIV genes, a suicide cassette and combinations thereof.", "Thus, the methods and compositions of the invention may be used to treat or prevent HIV with a CRISPR/Cas system where the single guide RNA comprises sequences to target the CCR5 or CXCR4 gene for integration of a suitable anti-HIV transgene.", "Additional non-limiting examples of sequences suitable for targeting are shown in Table 1.Genomic editing as described herein may be performed on any endogenous target.", "In certain embodiments, genomic modifications (e.g., transgene integration) are at a “safe harbor” gene.", "Specific “safe harbor” locations in the genome may be utilized for transgene integration that may either utilize the promoter found at that safe harbor locus, or allow the expressional regulation of the transgene by an exogenous promoter that is fused to the transgene prior to insertion.", "Several such “safe harbor” loci have been described, including the AAVS1 (also known as PPP1R12C) and CCR5 genes in human cells, Rosa26 and albumin (see co-owned U.S. Patent Publication Nos.", "2008/0299580; 2008/0159996; and 2010/0218264 and U.S. Pat.", "Nos.", "9,394,545 and 9,150,847) and Zp15 in plants (see U.S. Pat.", "No.", "8,329,986).", "An exogenous nucleic acid or transgene sequence can comprise, for example, one or more genes or cDNA molecules, or any type of coding or noncoding sequence, as well as one or more control elements (e.g., promoters).", "In addition, the exogenous nucleic acid sequence may produce one or more RNA molecules (e.g., small hairpin RNAs (shRNAs), inhibitory RNAs (RNAis), microRNAs (miRNAs), etc.).", "The exogenous nucleic acid sequence is introduced into the cell such that it is integrated into the genome of the cell (e.g.", "the PPP1R12C gene, which lies on chromosome 19, i.e.", "chr19:55602840-55624858).", "Integration of exogenous sequences can proceed through both homology-dependent and homology-independent mechanisms.", "Thus, the methods and compositions of the invention may be used to insert transgenes into a safe harbor locus with a CRISPR/Cas system where the single guide RNA comprises sequences to target the safe harbor gene.", "Non-limiting examples of sequences suitable for targeting are shown in Table 1.As described above, nucleases (e.g., CRISPR/Cas) specific for the safe harbor can be utilized such that the transgene construct is inserted by either HDR- or NHEJ-driven processes.", "Hypoxanthine-guanine phosphoribosyltransferase (HPRT) is an enzyme involved in purine metabolism encoded by the HPRT1 gene (chrX:133594175-133634698).", "HPRT1 is located on the X chromosome, and thus is present in single copy in males.", "HPRT1 encodes the transferase that catalyzes the conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate by transferring the 5-phosphorobosyl group from 5-phosphoribosyl 1-pyrophosphate to the purine.", "The enzyme functions primarily to salvage purines from degraded DNA for use in renewed purine synthesis.", "In the presence of 6-TG, HPRT is the enzyme responsible for the integration of 6-TG into DNA and RNA in the cell, resulting in blockage of proper polynucleotide synthesis and metabolism.", "Thus, 6-TG can be used as a selection agent to kill cells with a functional HPRT enzyme, and in addition, 6-TG can be given to cause mild immunoablation in subjects in need thereof.", "In a patient receiving a stem cell graft (e.g.", "hematopoietic or progenitor stem cells), a transgene of interest can be integrated into the HPRT locus, knocking out the HPRT1 gene.", "Such a cell population will be resistant to 6-TG toxicity.", "Thus when the transgene(+)/HPRT/(−) cells are infused into the patient, a mild course of 6-TG may increase engraftment of the cells, and those cells that engraft will have a greater percentage of transgene integration.", "HPRT has been targeted traditionally as a safe harbor for transgene integration (see for example Jasin et al., (1996) Proc Natl Acad Sci USA 93, p. 8804).", "It is constitutively expressed at a low level, and disruption of the HPRT gene can be selected for both in vitro and in vivo using 6-TG.", "However, integration into an HPRT locus via random integration can be difficult and occurs only at a low frequency.", "Use of specific nucleases will allow improved targeting of the HPRT locus.", "Thus, the methods and compositions of the invention may be used to insert transgenes into a HPRT locus with a CRISPR/Cas system where the single guide RNA of the invention comprises sequences to target the safe harbor gene.", "Preferred is targeting the HPRT gene (chrX:133594175-133634698).", "Especially preferred is to target sequences in intron 1 (at or near chromosome X: 133597660-133597662, 133603544-133603546 and 133604282-133604284).", "Also preferred is cleaving in exon 3, especially at or near chromosome x: 133609240-133609242.Another preferred location is in the active domain of the enzyme at or near chromosome X: 133627552-133627554.Thus, a sgRNA can be designed to bind to sequences anywhere in the HPRT locus, including, but not limited to, a sequence in one or more of these preferred targeting regions.", "Additional non-limiting examples of sequences suitable for targeting are shown in Table 1.Another useful gene to target with the methods and compositions of the invention is the IL2 receptor common gamma chain (encoded by the IL2RG gene, at or near chrX:70327254-70331481).", "The IL2RG protein is the common receptor chain in several cytokine receptors, and mutations in this gene are associated with X-linked severe combined immunodeficiency (“X-SCID”).", "Thus, targeting this gene with a CRISPR/Cas system and the sgRNAs of the invention to facilitate gene correction would be beneficial to X-SCID patients.", "Preferred is to target near the end of exon 1 (at or near Chr x: 70331274-70331276).", "Especially preferred is to target intron 1 at or near chromosome x: 70331196-70331198, or in exon 5, at or near chromosome x: 70329158-70329160.The albumin gene is highly expressed in the liver.", "Thus, insertion of a transgene into the endogenous albumin locus using a specific nuclease results in high level expression of the protein or gene product encoded by that transgene, which may also be secreted into the blood stream.", "The transgene can encode any protein or peptide including those providing therapeutic benefit.", "For example, the transgene can encode a protein involved in disorders of the blood, for example, clotting disorders, and a variety of other monogenic diseases.", "The transgene can be inserted into the endogenous albumin locus such that expression of the transgene is controlled by the albumin expressional control elements, resulting in liver-specific expression of the transgene encoded protein at high concentrations.", "Proteins that may be expressed may include clotting factors such as Factor VII, Factor VIII, Factor IX, Factor X, Factor XI, Factor XIII, vWF and the like, antibodies, proteins relevant to lyososomal storage, insulin, alpha 1-antitrypsin, and indeed any peptide or protein that when so expressed provides benefit.", "Thus, the methods and compositions of the invention may be used to insert transgenes into an albumin gene with a CRISPR/Cas system where the single guide RNA comprises sequences to target the albumin gene (at or near chr4:74269972-74287129).", "Preferred targets are those in the exonic sequences, for example at or near chr:4 74270073-74270883 (exon 1, especially preferred, most preferred at chromosome 4: 74270385-74270485), 74270840-74272396 (exon 2, especially preferred at or near chromosome 4: 74270840-74272396), 74272428-74274361 (exon 3), 74274472-74275122 (exon 4), 74275154-74276079 (exon 5), 74276076-74277763 (exon 6), 74277792-74279187 (exon 7), 74279301-74280802 (exon 8), 74280834-74282023 (exon 9), 74282020-74283298 (exon 10), 74283336-74283855 (exon 11), 74283978-74285274 (exon 12, especially preferred), 74285306-74286021 (exon 13, especially preferred), and 74285988-74286859 (exon 14, especially preferred).", "Thus, a sgRNA can be designed to bind to sequences anywhere in the albumin locus, including, but not limited to, a sequence in one or more of these preferred targeting regions.", "Additional non-limiting examples of sequences suitable for targeting are shown in Table 1.Lysosomal storage diseases (LSDs) are a group of rare metabolic monogenic diseases characterized by the lack of functional individual lysosomal proteins normally involved in the breakdown of waste lipids, glycoproteins and mucopolysaccharides.", "These diseases are characterized by a buildup of these compounds in the cell since it is unable to process them for recycling due to the mis-functioning of a specific enzyme.", "The most common examples are Gaucher's (glucocerebrosidase deficiency—gene name: GBA), Fabry's (α galactosidase deficiency—GLA), Hunter's (iduronate-2-sulfatase deficiency-IDS), Hurler's (alpha-L iduronidase deficiency—IDUA), and Niemann-Pick's (sphingomyelin phosphodiesterase 1deficiency—SMPD1) diseases.", "When grouped all together, LSDs have an incidence in the population of about 1 in 7000 births.", "These diseases have devastating effects on those afflicted with them.", "They are usually first diagnosed in babies who may have characteristic facial and body growth patterns and may have moderate to severe mental retardation.", "Treatment options include enzyme replacement therapy (ERT) where the missing enzyme is given to the patient, usually through intravenous injection in large doses.", "Such treatment is only to treat the symptoms and is not curative, thus the patient must be given repeated dosing of these proteins for the rest of their lives, and potentially may develop neutralizing antibodies to the injected protein.", "Often these proteins have a short serum half-life, and so the patient must also endure frequent infusions of the protein.", "For example, Gaucher's disease patients receiving the Cerezyme® product (imiglucerase) must have infusions three times per week.", "Production and purification of the enzymes is also problematic, and so the treatments are very costly (>$100,000 per year per patient).", "Thus, the specific nucleases of the invention may be used to insert genes encoding the missing wild type versions of the proteins involved in lysosomal storage diseases into safe harbor loci such as albumin for expression and treatment of the LSD.", "Hemophilia B is a genetic disorder of the blood-clotting system, characterized by bleeding into joints and soft tissues, and by excessive bleeding into any site experiencing trauma or undergoing surgery.", "While hemophilia B is clinically indistinguishable from hemophilia A, factor VIII (FVIII) is deficient or absent in hemophilia A and factor IX (FIX or F.IX) is deficient or absent in patients with hemophilia B.", "Factor IX encodes one of the serine proteases involved with the coagulation system, and it has been shown that restoration of even 3% of normal circulating levels of wild type Factor IX protein can prevent spontaneous bleeding.", "Gene therapy, including liver-directed gene therapy protocols and direct intramuscular injection, involving the introduction of plasmid and other vectors (e.g., AAV) encoding a functional FIX protein have been described for treatment of hemophilia B.", "See, e.g., U.S. Pat.", "No.", "6,936,243; Lee et al., (2004) Pharm.", "Res.", "7:1229-1232; Graham et al., (2008) Genet Vaccines Ther.", "3:6-9.However, in these protocols, the formation of inhibitory anti-factor IX (anti-FIX) antibodies and antibodies against the delivery vehicle remains a major complication of FIX protein replacement-based treatment for hemophilia B.", "Thus, use of designed nucleases and related technology to either correct the endogenous Factor VIII or Factor IX gene or introduce a wild type copy of the gene in a safe harbor locus can restore clotting activity in a treated patient.", "A preferred targeting region for the Factor VIII gene is at or near the gene sequence located at chrX:154064064-154250998.Especially preferred for targeting the Factor VIII gene is the region of intron 22, which is a site of common inversion evens that account for up to 50% of FVIII mutations in severe hemophilia A patients, located at or near chrX:154091503-154124351.For the Factor IX (F.IX) gene, preferred for targeting is the gene sequence located at or near chrX:138,612,895-138,645,617.Especially preferred are targets in regions in intron 1, e.g.", "at or near chrX:138613760-138613816, chrX:138618832-138618887 and/or chrX:138613815-138613872.Thus, a sgRNA can be designed to bind to sequences anywhere in the Factor VIII or Factor IX loci, including, but not limited to, a sequence in one or more of these preferred targeting regions.", "Parkinson's disease (PD) is a neurodegenerative disease that afflicts approximately 4-6 million people worldwide.", "In the United States, approximately one to two hundred people per 100,000 have PD.", "The prevalence of PD increases in the older population, with approximately 4% of people over the age of 80 suffering from this disease (Davie (2008) Brit Med Bull 86(1) p. 109), although 10% of patients are under 40 years of age (Kumari (2009) FEBS J.", "276(22) p. 6455).", "It appears that many factors can play a role in disease onset and/or progression of PD.", "For example, genetic mutations in the leucine rich repeat kinase 2 gene (LRRK2, also known as PARKS) has been identified to be involved in both familial and sporadic forms of PD.", "In fact, studies suggest that LRRK2 mutations may be responsible for between 5 and 13% of familial PD, and from 1 to 5% of sporadic PD.", "The protein itself is a large (>280 kD) multidomain protein containing the following known domains: armadillo (ARM), ankryn (ANK), LRR, Ras of complex proteins (ROC), C-terminal of ROC (COR), mitogen-activated protein kinase kinase kinase and WD40.Thus, LRRK2 contains several protein-protein interactive domains (ARM/ANK, LRR and WD40) suggesting that LRRK2 plays a role in protein complex formation (Kumari, ibid).", "Several clusters of mutations have been identified which fall across its length of the gene, with the majority of pathological mutations clustering in the enzymatic domains of the protein.", "Specifically, the LRRK2 mutation G2019S has been suggested to play an important role in PD in some ethnicities.", "The mutation is autosomal dominant and the lifetime penetrance for the mutation has been estimated at 31.8%.", "The SNP responsible for this missense mutation in patients is annotated as rs34637584 in the human genome, and is a G to A substitution at the genomic level (6055G>A).", "This LRRK2 mutation can be referred to either as G2019S or 6055G>A and is found at or near chr12:40734202.The G2019S mutation has been shown to increase LRRK2 kinase activity, and is found in the within the activation domain or protein kinase-like domain of the protein (Luzon-Toro (2007) Hum Mol Genet 16(17) p. 2031).", "Thus, a specific nuclease can be used to correct a mutation in the LRRK2 gene for the treatment of PD.", "Thus, the methods and compositions of the invention may be used to correct a LRRK2 gene with a CRISPR/Cas system where the single guide RNA comprises sequences to target the LRRK2 gene.", "Especially preferred is a sgRNA designed to target at or near chr12:40734202-40734202.Non-limiting examples of sequences suitable for targeting are shown in Table 1.Trinucleotide repeat expansion disorders were first characterized in the early 1990s (see Di Prospero and Fischbeck, (2005) Nature Reviews Genetics Vol 6: 756-765).", "These disorders involve the localized expansion of unstable repeats of sets of three nucleotides and can result in loss of function of the gene in which the repeat resides, a gain of toxic function, or both.", "Trinucleotide repeats can be located in any part of the gene, including non-coding and coding gene regions.", "Repeats located within the coding regions typically involve either a repeated glutamine encoding triplet (CAG) or an alanine encoding triplet (CGA).", "Expanded repeat regions within non-coding sequences can lead to aberrant expression of the gene while expanded repeats within coding regions (also known as codon reiteration disorders) may cause mis-folding and protein aggregation.", "Huntington's Disease (HD), also known as Huntington's Chorea, is a progressive disorder of motor, cognitive and psychiatric disturbances.", "The mean age of onset for this disease is age 35-44 years, although in about 10% of cases, onset occurs prior to age 21, and the average lifespan post-diagnosis of the disease is 15-18 years.", "Prevalence is about 3 to 7 among 100,000 people of western European descent.", "The disease is associated with expansion of the CAG repeat region in the endogenous Huntintin gene (Htt, chr4:3076237-3245687).", "Normal Htt alleles contain 15-20 CAG repeats, while alleles containing 35 or more repeats can be considered potentially HD causing alleles and confer risk for developing the disease.", "Alleles containing 36-39 repeats are considered incompletely penetrant, and those individuals harboring those alleles may or may not develop the disease (or may develop symptoms later in life) while alleles containing 40 repeats or more are considered completely penetrant and no asymptomatic persons containing HD alleles with this many repeats have been reported.", "Those individuals with juvenile onset HD (<21 years of age) are often found to have 60 or more CAG repeats.", "Thus, the methods and compositions of the invention may be used to disrupt a Htt allele with a CRISPR/Cas system where the single guide RNA comprises sequences to target the expanded Htt gene.", "Especially preferred is targeting chromosome 4, at or near 3071604-3081660.The methods and compositions of the invention may also be used to selectively repress a mutant Htt allele using a CRISPR/Cas system fusion protein comprising a repression domains.", "Non-limiting examples of sequences suitable for targeting are shown in Table 1.Retinitis pigmentosa (RP) refers to a diverse group of hereditary diseases affecting two million people worldwide that lead to incurable blindness.", "RP is one of the most common forms of inherited retinal degeneration, and there are multiple genes whose mutation can lead to RP.", "More than 100 mutations in 44 genes expressed in rod photoreceptors have thus far been identified, accounting for 15% of all types of retinal degeneration, most of which are missense mutations and are usually autosomal dominant.", "Rhodopsin is a pigment of the retina that is involved in the first events in the perception of light.", "It is made of the protein moiety opsin covalently linked to a retinal cofactor.", "Rhodopsin is encoded by the RHO gene (chr3:129247482-129254187), and the protein has a molecular weight of approximately 40 kD and spans the membrane of the rod cell.", "The retinal cofactor absorbs light as it enters the retina and becomes photoexcited, causing it to undergo a change in molecular configuration, and dissociates from the opsin.", "This change initiates the process that eventually causes electrical impulses to be sent to the brain along the optic nerve.", "In relation to RP, more than 80 mutations in the rhodopsin gene have been identified that account for 30% of all Autosomal Dominant Retinitis Pigmentosa (ADRP) in humans (Dryj a et al., (2000) Invest Opthalmol Vis Sci 41: 3124-3127).", "Three point mutations in the human rhodopsin gene (leading to P23H, Q64X and Q344X in the protein sequence) are known to cause ADRP in humans.", "See, e.g., Olsson et al., (1992) Neuron 9(5):815-30.The P23H mutation is the most common rhodopsin mutation in the United States.", "Due to problems with protein folding, P23H rhodopsin only partially reconstitutes with retinal in vitro (Liu et al., (1996) Proc Nat'l Acad Sci 93:4554-4559), and mutant rhodopsin expressed in transgenics causes retinal degeneration (Goto et al., (1995) Invest Opthalmol Vis Sci 36:62-71).", "Thus, the methods and compositions of the invention may be used to disrupt a RHO allele with a CRISPR/Cas system where the single guide RNA comprises sequences to target a human RHO gene (at or near chr3:129247482-129254187).", "Targeting RHO at specific locations is useful for facilitating gene correction.", "Preferred target locations include exon 1 (at or near chr3:129247577-129247937 for correcting the sequence associated with the P23H or Q64X mutations), and exon5 (at or near chr3:129251376-129251615).", "Non-limiting examples of sequences suitable for targeting are shown in Table 1.Lung diseases, including inherited disorders such as Cystic Fibrosis (CF) and Surfactant Protein B (SP-B) Deficiency remain an issue in pediatric populations.", "SP-B deficiency is a rare lung disease where protein and fat molecules accumulate in the distant parts of the lungs and affect breathing.", "The disease is caused by a deficiency of the lung surfactant protein B, primarily due to a defect in the SFTPB gene (located at or near chr2:85884440-85895374) which encodes the pulmonary-associated surfactant B protein (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth.", "The most common mutation in SP-B deficiency is a mutation designated “121ins2” which results in the nucleotide “C” at position 131 in the mRNA being converted into “GAA.", "(in the genomic sequence, this corresponds to 375C-GAA and is located in exon 4).", "Thus, the methods and compositions of the invention can be used to targets a CRISPR/Cas system using a sgRNA of the invention to the SFTPB gene at or near chr2:85884440-85895374, and most preferably, to exon 4 (at or near chr2:85893740-85893865).", "CF is an autosomal recessive disorder affecting 1 in 1500 to 4000 live births, and is one of the most common inherited pediatric disorders.", "The primary defect in CF is in the regulation of epithelial chloride transport by a chloride channel protein encoded by the cystic fibrosis transmembrane conductance regulator (CFTR) gene (located chr7:117120017-117308718).", "See, e.g., Kerem et al., (1989) Science 245:1073-1080; Kreda et al., (2005) Mol Biol Cell 16:2154-2167.About 70% of mutations observed in CF patients result from deletion of three base pairs in CFTR's nucleotide sequence, resulting in the loss of the amino acid phenylalanine located at position 508 in the protein (a mutation referred to as ΔF508, (located in exon 11).", "In a wild type genome, amino acid 507 is an isoleucine, and is encoded by the codon TAG where the G is nucleotide 1652 in the gene.", "Amino acid 508 is a phenylalanine, encoded by AAA.", "In the Δ508 mutation, the G from the 507 codon is deleted along with the first two As of the 508 codon, such that the mutation has the sequence TAA at the deleted 507-508 encoding position.", "TAA also encodes an isoleucine, but the phenylalanine at wild type position 508 is lost.", "For the ΔI507 deletion, either the isoleucine at position 506 or 507 is deleted.", "For this mutation, the nucleotides at 1648-1650 or 1651-1653 are lost, or some combination thereof to result in only one isoleucine in the resultant protein.", "Compound (heterozygous) mutations (ΔF508 and ΔI507) have also been documented.", "See, e.g., Orozco et al., (1994) Am J Med Genet.", "51(2):137-9.CF patients, either compound heterozygous ΔI507/ΔF508 or homozygous ΔF508/ΔF508, fail to express the fully glycosylated CFTR protein and the partially glycosylated protein is not expressed on the cell surface (see, e.g., Kreda et al., (2005) Mol Biol Cell 16:2154-2167; Cheng et al., (1990) Cell 63:827-834) as is required for CFTR function.", "Individuals bearing either the ΔI507 or ΔF508 CFTR mutations at only one allele (i.e.", "wt/ΔI507 or wt/ΔF508) are CF carriers and exhibit no defects in lung cell function.", "See, e.g., Kerem et al., (1990) Proc Natl Acad Sci USA 87:8447-8451.Thus, the methods and compositions of the invention may be used to disrupt or correct a CFTR allele with a CRISPR/Cas system where the single guide RNA comprises sequences to target a human CFTR gene.", "Especially preferred for targeting is at or near chr7:117227793-117227887).", "Non-limiting examples of sequences suitable for targeting are shown in Table 1.Muscular dystrophies are diseases that are characterized by a progressive degeneration and weakening of muscle groups.", "One well known muscular dystrophy is Duchenne's muscular dystrophy, which is an X-linked disease that afflicts 1 in every 3500 boys.", "It is caused by the lack of the protein dystrophin in the individual muscle cells, and symptoms first appear when the child is approximately 3 years old, and depending on the severity of the disease, death can occur when the patient is in his twenties.", "The gene encoding dystrophin, DMD (located at or near chrX:31137345-33229673), is extremely large and covers 2.4 megabases of DNA comprising 79 exons that encode a 14 kb mRNA.", "In patients that lack functional dystrophin, approximately 40% have point mutations that cause a frameshift in the coding sequence such that during translation, a premature stop is encountered resulting in the production of a truncated or non-functioning protein.", "The other 60% have large insertions or deletions that also result in alteration of frame and similarly result in production of a non-functional protein (Nowak and Davies (2004) EMBO Reports 5(9): 872-876).", "Patients with non-functional dystrophin have the most severe disease, which is also known as Duchenne's Muscular Dystrophy (DMD).", "Other patients, whose mutations are characterized by gene deletions of regions that encode internal portions of dystrophin, resulting in less functional dystrophin protein as compared to wild type, may have less severe disease, which is called Becker Muscular Dystrophy (BMD).", "BMD patients have been known to live into their 50's.", "Targeting the DMD gene may be useful for gene correction of point mutations or for changing splicing patterns of the mRNA transcript, allowing the cell to produce a functional dystrophin protein.", "Thus, a sgRNA can be designed to bind to sequences anywhere in the DMD locus, at or near chrX:31137345-33229673.Adoptive immunotherapy is the practice of achieving highly specific T cell stimulation of a certain subpopulation of CTLs that possess a high-avidity TCR to the tumor antigen, stimulating and expanding them ex vivo, and then introducing them into the patient.", "Adoptive immunotherapy is particularly effective if native lymphocytes are removed from the patient before the infusion of tumor-specific cells.", "The idea behind this type of therapy is that if the introduced high-avidity CTLs are successful, once the tumor has been cleared, some of these cells will remain as memory T cells and will persist in the patient in case the cancer reappears.", "However, transfer of any TCR transgenes into host T cells carries with it the caveats associated with most gene transfer methods, namely, unregulated and unpredictable insertion of the TCR transgene expression cassette into the genome, often at a low level.", "Such poorly controlled insertion of the desired transgene can result in effects of the transgene on surrounding genes as well as silencing of the transgene due to effects from the neighboring genes.", "In addition, the endogenous TCR genes that are coexpressed in the T cell engineered with the introduced TCR transgene could cause undesired stimulation of the T cell by the antigen recognized by the endogenous TCR, undesired stimulation of the T cell by unintended antigens due to the mispairing of the TCR transgene with the endogenous TCR subunits creating a novel TCR complex with novel recognition properties, or can lead to suboptimal stimulation against the antigen of interest by the creation of inactive TCRs due to heterodimerization of the transgene encoded TCR subunits with the endogenous TCR proteins.", "In fact, the risk of severe autoimmune toxicity resulting from the formation of self-reactive TCR from mispairing of endogenous and exogenous chains has been recently highlighted in a murine model (Bendle et al., (2010) Nature Medicine 16:565-570) and in human cells (van Loenen et al., (2010) Proc Natl Acad Sci USA 107:10972-7).", "Additionally, the tumor-specific TCR may be expressed at suboptimal levels on the cell surface, due to competition with the endogenous and mispaired TCR for the CD3 molecules, required to express the complex on the cell surface.", "Low TCR expression affects the avidity and efficacy of the transgenic T cell.", "Examples of targets that can be used to make high affinity TCRs against for introduction into a T cell are WT1 and NYEso.", "Thus, the methods and compositions of the invention may be used to disrupt or correct an endogenous TCR gene with a CRISPR/Cas system where the single guide RNA comprises sequences to target a human TCR alpha (TRAC or TCRA, located at or near chr6:42883727-42893575) or beta (TRBC or TCRB, located at or near chr7:142197572-142198055) gene.", "Non-limiting examples of sequences suitable for targeting are shown in Table 1.The programmed death receptor (PD1 or PD-1, also known as PDCD1) has been shown to be involved in regulating the balance between T cell activation and T cell tolerance in response to chronic antigens.", "Upon T cell activation, PD1 expression is induced in T cells.", "The ligands for the PD1 receptor are PD1 ligand (PDL1 also known as B7-H1 and CD272) and PDL2 (also known as B7-DC and CD273), and are normally expressed in antigen presenting cells and in the periphery.", "PD1-PDL (PD1 ligand) coupling causes deactivation of the T cell and is involved in inducing T cell tolerance (see Pardoll (2012) Nat Rev 12:252).", "During HIV1 infection, expression of PD1 has been found to be increased in CD4+ T cells, and PDL1 expression is increased on antigen presenting cells (APCs), tipping the balance between T cell inhibition and T cell stimulation towards T cell inhibition (see Freeman et al., (2006) J Exp Med 203(10):2223-2227).", "It is thought that PD1 up-regulation is somehow tied to T cell exhaustion (defined as a progressive loss of key effector functions) when T cell dysfunction is observed in the presence of chronic antigen exposure as is the case in HIV infection.", "PD1 up-regulation may also be associated with increased apoptosis in these same sets of cells during chronic viral infection (see Petrovas et al., (2009) J Immunol.", "183(2):1120-32).", "PD1 may also play a role in tumor-specific escape from immune surveillance.", "It has been demonstrated that PD1 is highly expressed in tumor-specific cytotoxic T lymphocytes (CTLs) in both chronic myelogenous leukemia (CML) and acute myelogenous leukemia (AML).", "PD1 is also up-regulated in melanoma infiltrating T lymphocytes (TILs) (see Dotti (2009) Blood 114 (8): 1457-58).", "Tumors have been found to express the PD1 ligand PD-L1 or, more rarely, the PD1 ligand PDL2 which, when combined with the up-regulation of PD1 in CTLs, may be a contributory factor in the loss in T cell functionality and the inability of CTLs to mediate an effective anti-tumor response.", "Researchers have shown that in mice chronically infected with lymphocytic choriomeningitis virus (LCMV), administration of anti-PD1 antibodies blocked PD1-PDL interaction and was able to restore some T cell functionality (proliferation and cytokine secretion), leading to a decrease in viral load (Barber et al., (2006) Nature 439(9): 682-687).", "Additionally, a fully human PD-1 specific IgG4 monoclonal antibody has been tested in the clinic in an oncology setting on patients with a variety of disease backgrounds (advanced melanoma, renal cell carcinoma, non-small cell lung cancer, colorectal cancer or prostate cancer).", "Clinical activity was observed in melanoma, renal cell and non-small cell lung cancer patients and preliminary data suggested that detection of PD1 ligand expression by the tumor prior to treatment correlated with clinical outcome (see Wolfe (2012) Oncology Business Review, July; and Pardoll, ibid).", "Thus, the methods and compositions of the invention may be used to disrupt a PD1 allele with a CRISPR/Cas system where the single guide RNA comprises sequences to target a human PD1 gene (chr2:242792033-242801058).", "One preferred region for targeting the PD1 gene for knock out is at or near the region near that ATG protein translation initiation site.", "This corresponds to nucleotides chr2: 242800981-242800982 of the PD1 gene.", "Especially preferred are target sites the PD1 gene where the PAM position for the S. pyogenes Cas9 is located at or near chromosome 2 at position 242800980-242800981, 242800975-242800976, 242800971-242800972, 242800970-242800971, 242800967-242800968, and 242800965-242800966.Another especially preferred targeting location is around the region near the PD-1 ligand binding domain (chromosome 2, nucleotides 242794834-242794835 and 242794828-242794829).", "Another preferred region for targeting is at or near the region near the immunoreceptor tyrosine-based switch motif (e.g., chromosome 2 242793349-242793350, 242793338-242793339, 242793330-242793331 or 242793327-242793328).", "Mutations in this region disable PD1 function.", "Especially preferred are target sites for the S. pyogenes Cas9 protein at positions at or near chromosome 2: 242800953-242800979, 242794976-242795005, 242794416-242794444 and 242793405-242793433.A preferred targeting region for the Factor VIII gene is at or near the gene sequence located at chrX:154064064-154250998.Especially preferred for targeting the Factor VIII gene is the region of intron 22, which is a site of common inversion evens that account for up to 50% of FVIII mutations in severe hemophilia A patients, located at or near chrX:154091503-154124351.For the Factor IX (F.IX) gene, preferred for targeting is the gene sequence located at or near chrX:138,612,895-138,645,617.Especially preferred are targets in regions in intron 1, e.g.", "at or near chrX:138613760-138613816, chrX:138618832-138618887 and/or chrX:138613815-138613872.Thus, a sgRNA can be designed to bind to sequences anywhere in the PD1 locus, including, but not limited to, a sequence in one or more of these preferred targeting regions.", "Non-limiting examples of sequences suitable for targeting are shown in Table 1.Another modulator of T cell activity is the CTLA-4 receptor.", "Similar to the T cell receptor CD28, CTLA-4 interacts with the CD80 and CD86 ligands on antigen presenting cells.", "But while interaction of these antigens with CD28 causes activation of T cells, interaction of CD80 or CD86 with CTLA-4 antagonizes T-cell activation by interfering with IL-2 secretion and IL-2 receptor expression, and by inhibiting the expression of critical cell cycle components.", "CTLA-4 is not found on the surface of most resting T cells, but is upregulated transiently after T-cell activation.", "Thus CTLA-4 is also involved in the balance of activating and inhibiting T cell activity (see Attia et al., (2005) J Clin Oncol.", "23(25): 6043-6053).", "Initial clinical studies involving the use of CTLA 4 antibodies in subjects with metastatic melanoma found regression of the disease (Attia, ibid), but later studies found that subject treated with the antibodies exhibited side effects of the therapy (immune-related adverse events: rashes, colitis, hepatitis etc.)", "that seemed to be related to a breaking of self-tolerance.", "Analysis of this data suggested that greater tumor regression as a result of the anti-CTLA4 antibody correlated directly with a greater severity of immune-related adverse events (Weber (2007) Oncologist 12(7): 864-872).", "Thus, the methods and compositions of the invention may be used to disrupt a CTLA-4 gene with a CRISPR/Cas system where the single guide RNA comprises sequences to target a human CTLA-4 gene, located at or near chr2:204732511-204738683.Non-limiting examples of sequences suitable for targeting are shown in Table 1.Chimeric Antigen Receptors (CARs) are molecules designed to target immune cells to specific molecular targets expressed on cell surfaces.", "In their most basic form, they are receptors introduced to a cell that couple a specificity domain expressed on the outside of the cell to signaling pathways on the inside of the cell such that when the specificity domain interacts with its target, the cell becomes activated.", "Often CARs are made from variants of T-cell receptors (TCRs) where a specificity domain such as a scFv or some type of receptor is fused to the signaling domain of a TCR.", "These constructs are then introduced into a T cell allowing the T cell to become activated in the presence of a cell expressing the target antigen, resulting in the attack on the targeted cell by the activated T cell in a non-MHC dependent manner (see Chicaybam et al., (2011) Int Rev Immunol 30:294-311).", "Currently, tumor specific CARs targeting a variety of tumor antigens are being tested in the clinic for treatment of a variety of different cancers.", "Examples of these cancers and their antigens that are being targeted includes follicular lymphoma (CD20 or GD2), neuroblastoma (CD171), non-Hodgkin lymphoma (CD20), lymphoma (CD19), glioblastoma (IL13Rα2), chronic lymphocytic leukemia or CLL and acute lymphocytic leukemia or ALL (both CD19).", "Virus specific CARs have also been developed to attack cells harboring virus such as HIV.", "For example, a clinical trial was initiated using a CAR specific for Gp100 for treatment of HIV (Chicaybam, ibid).", "As useful as it is to develop a technology that will cause a T cell to re-direct its attention to specific cells such as cancer cells, there remains the issue that these target cells often express of PD-1 ligand.", "As such, the PD1-PD-L1/PD-L2 interaction enables the tumor to escape action by the CAR-targeted T cell by deactivating the T cells and increasing apoptosis and cell exhaustion.", "Additionally, the PD1-PDL interactions are also involved in the repression of the T cell response to HIV, where increased expression of both PD1 and PDL leads to T cell exhaustion.", "Induction of CTLA-4 expression on activated T cells is also one of the first steps to damping the immune response, and thus a T cell armed with a CAR might become inactive due to the engagement of this system designed to balance T cell activation with T cell inhibition.", "Thus, the CRISPR/Cas system of the invention can be used with the sgRNAs of the invention described above to knockout CTLA-4 and/or PD1 in a T cell comprising a CAR.", "MHC antigens were first characterized as proteins that played a major role in transplantation reactions.", "Rejection is mediated by T cells reacting to the histocompatibility antigens on the surface of implanted tissues, and the largest group of these antigens is the major histocompatibility antigens (MHC).", "MHC proteins are of two classes, I and II.", "The class I MHC proteins are heterodimers of two proteins, the α chain, which is a transmembrane protein encoded by the MHC1 gene, and the β2 microblogulin chain, which is a small extracellular protein that is encoded by a gene that does not lie within the MHC gene cluster.", "The α chain folds into three globular domains and when the β2 microglobulin chain is associated, the globular structure complex is similar to an antibody complex.", "The foreign peptides are presented on the two most N-terminal domains which are also the most variable.", "Class II MHC proteins are also heterodimers, but the heterodimers comprise two transmembrane proteins encoded by genes within the MHC complex.", "The class I MHC:antigen complex interacts with cytotoxic T cells while the class II MHC presents antigens to helper T cells.", "In addition, class I MHC proteins tend to be expressed in nearly all nucleated cells and platelets (and red blood cells in mice) while class II MHC protein are more selectively expressed.", "Typically, class II MHC proteins are expressed on B cells, some macrophage and monocytes, Langerhans cells, and dendritic cells.", "The class I HLA gene cluster in humans comprises three major loci, B, C and A, as well as several minor loci.", "HLA-A, H:A-B and HLA-C are the HLA class I heavy chain paralogues.", "The class I molecule is a heterodimer consisting of a MHC alpha heavy chain (HLA-A, HLA-B or HLA-C) and a light chain (beta-2 microglobulin).", "The heavy chain is anchored in the membrane.", "Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen.", "The heavy chain is approximately 45 kDa and its gene contains 8 exons.", "Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.", "Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule.", "A preferred region for targeting an sgRNA in HLA-A, B or C is within the gene sequence, (e.g.", "chr6:29910247-29912868 for HLA-A, chr6:31236526-31239913 for HLA-B, and chr6:31236526-31239125 for HLA-C).", "Especially preferred is targeting sequences within the leader sequence (e.g., at or near chr6:31324936-31324989 for HLA-B), the alpha 1 and alpha 2 domains (e.g.", "at or near chr6:31324863-31324935 and chr6:31324735-31324862, respectively for HLA-B) and the alpha3 domain (e.g.", "at or near chr6:31324465-31324734 for HLA-B).", "The class II HLA cluster also comprises three major loci, DP, DQ and DR, and both the class I and class II gene clusters are polymorphic, in that there are several different alleles of both the class I and II genes within the population.", "HLA-DPA1, HLA-DQA1 and HLA-DRA belong to the HLA class II alpha chain paralogues.", "This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane.", "They play a central role in the immune system by presenting peptides derived from extracellular proteins.", "Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).", "The alpha chains are approximately 33-35 kDa and their genes (chr6_ssto_hap7:3,754,283-3,759,493 for HLA-DRA, chr6:32605183-32611429 for HLA-DQ and chr6:33032346-33048555 for HLA-DPA) contain 5 exons.", "Exon one (e.g.", "at or near chr6:33041248-33041347 for HLA-DPA1) encodes the leader peptide, exons 2 and 3 (e.g.", "at or near chr6:33037418-33037663 and chr6:33036796-33037077 for HLA-DPA1) encode the two extracellular domains, exon 4 (e.g.", "at or near hr6:33036427-33036581 for HLA-DPA1) encodes the transmembrane domain and the cytoplasmic tail.", "Thus, especially preferred regions to target with a CRIPSR-Cas system of the invention are within exons one, two and three.", "Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.", "Thus, a sgRNA can be designed to bind to sequences anywhere in the HLA-DPA1, HLA-DQ1 or HLA-DRA loci, including, but not limited to, a sequence in one or more of these preferred targeting regions.", "There are also several accessory proteins that play a role in HLA functioning as well.", "The Tap1 (encoded at chr6:32812986-32821748) and Tap2 (encoded at chr6:32793187-32806547) subunits are parts of the TAP transporter complex that is essential in loading peptide antigens on to the class I HLA complexes, and the LMP2 and LMP7 proteosome subunits play roles in the proteolytic degradation of antigens into peptides for display on the HLA.", "Reduction in LMP7 (chr6_dbb_hap3:4089872-4093057) has been shown to reduce the amount of MEW class I at the cell surface, perhaps through a lack of stabilization (see Fehling et al., (1999) Science 265:1234-1237).", "In addition to TAP and LMP, there is the tapasin gene (chr6:33271410-33282164), whose product forms a bridge between the TAP complex and the HLA class I chains and enhances peptide loading.", "Reduction in tapasin results in cells with impaired MEW class I assembly, reduced cell surface expression of the MHC class I and impaired immune responses (see Grandea et al., (2000) Immunity 13:213-222 and Garbi et al., (2000) Nat Immunol 1:234-238).", "Regulation of class II MHC expression is dependent upon the activity of the MHCII enhanceosome complex.", "The enhanceosome components (one of the most highly studied components of the enhanceosome complex is the RFX5 gene product (see Villard et al., (2000) MCB 20(10): 3364-3376)) are nearly universally expressed and expression of these components does not seem to control the tissue specific expression of MHC class II genes or their IFN-γ induced up-regulation.", "Instead, it appears that a protein known as CIITA (class II transactivator) which is a non-DNA binding protein, serves as a master control factor for MCHII expression.", "In contrast to the other enhanceosome members, CIITA does exhibit tissue specific expression, is up-regulated by IFN-γ, and has been shown to be inhibited by several bacteria and viruses which can cause a down regulation of MHC class II expression (thought to be part of a bacterial attempt to evade immune surveillance (see Leibund Gut-Landmann et al., (2004) Eur.", "J. Immunol 34:1513-1525)).", "Thus, the methods and compositions of the invention may be used to disrupt an HLA gene or an HLA regulatory gene with a CRISPR/Cas system where the single guide RNA comprises sequences to target a human HLA gene or HLA regulatory gene.", "A sgRNA can be designed to bind to sequences anywhere in the HLA locus, including, but not limited to, a gene sequence encoding HLA-A, HLA-B, HLA-C, HLA-DPA, HLA-DQ or HLA-DRA, and to preferred targeting regions within these genes discussed above.", "Additionally, sgRNAs can be designed to bind to sequences in genes whose products interact with the MHC proteins, including TAP1, TAP2, LMP2, LMP7, and tapasin, or to sequences in genes whose products regulate the expression of these genes, including those in the MHCII enhanceosome complex (RFX5 (chr1:151313116-151319769) and CIITA (chr16:10971055-11002744).", "Non-limiting examples of sequences suitable for targeting are shown in Table 1.Disclosed herein are compositions and methods useful for modulation of expression and targeted cleavage and alteration of genes in plants, particularly paralogous genes in plants.", "Regulation of a paralogous gene can be modulated, e.g., by using engineered transcription factors or modifying gene regulatory regions.", "Genes can be altered, e.g., by targeted cleavage followed by intrachromosomal homologous recombination or by targeted cleavage followed by homologous recombination between an exogenous polynucleotide (comprising one or more regions of homology with the gene nucleotide sequence) and a genomic sequence.", "A non-limiting example of a paralogous gene in plants is the EPSPS gene.", "Thus, the methods and compositions of the invention may be used to disrupt an EPSPS gene with a CRISPR/Cas system where the single guide RNA comprises sequences to target a plant EPSPS gene.", "The present disclosure provides methods and compositions for expressing one or more products of an exogenous nucleic acid sequence (i.e.", "a protein or a RNA molecule) that has been integrated into a Zp15 gene in a plant cell.", "As shown in the co-owned U.S. Pat.", "No.", "8,329,986, the integration of one or more exogenous sequences at or near the Zp15 locus does not appear to impair the ability of the host plant to regenerate, flower or produce seed and, optionally, allows heritable transmission of the exogenous sequence(s) over generations.", "The exogenous nucleic acid sequences can comprise, for example, one or more genes or cDNA molecules, or any type of coding or noncoding sequence, as well as one or more control elements (e.g., promoters).", "For instance, herbicide tolerance genes can be integrated into this locus to produce crop plants with the desired herbicide resistance.", "Cells containing exogenous nucleic acids at or near the Zp15 locus can also contribute to the gametophyte (germline) and therefore be transmitted to progeny in subsequent generations.", "Thus, the methods and compositions of the invention may be used to disrupt a Zp15 gene with a CRISPR/Cas system where the single guide RNA comprises sequences to target a plant ZP15 gene.", "The present disclosure provides compositions and methods for modulating expression and for targeted alteration in whole plants or plant cells of one or more plant genes involved in fatty acid biosynthesis, thereby altering the fatty acid composition in the whole plant or plant cells.", "Whole plants or plant cells can be from monocotyledonous (monocots) or dicotyledonous (dicots) plant species, including in some particular embodiments oil-producing plants, and also include cultured cells, cells in a plant at any stage of development, and plant cells that have been removed from a whole plant and which cells (or their descendants) will be regenerated into plants.", "Plant cells can contain one or more homologous or paralogous gene sequences, any number of which or all of which can be targeted for modification by the methods disclosed herein.", "In one aspect, described herein is a DNA-binding domain (e.g., Cas protein) that specifically binds to a gene involved in a plant fatty acid biosynthesis pathway.", "In some embodiments, the gene is a Brassica napus gene.", "In some particular embodiments, the Brassica napus gene can encode Acetyl-COA carboxylase (ACCase), β-ketoacyl-ACP synthetases (KAS, e.g., KASI-KAS IV), Fatty acid thioesterase B (FATB, e.g., FATB1-FATB5, or other plastidial thioesterases), Fatty acid synthase (FAS), Fatty acid elongase (FAE, e.g., FAE1), Fatty acid thioesterase A (FatA), Fatty acid desaturase (Fad2, Fad3), plastidial G-3-P dehydrogenase (GPDH), glycerokinase (GK), stearoyl-acyl carrier protein desaturase (S-ACP-DES), and oleoyl-ACP hydrolase.", "In some particular embodiments, the gene can be an ortholog or a homolog of these genes in other oil-producing plant species.", "Thus, the methods and compositions of the invention may be used to disrupt a gene involved with fatty acid biosynthesis with a CRISPR/Cas system where the single guide RNA comprises sequences to target a fatty acid synthesis gene.", "Malate dehydrogenase (MDH) catalyzes a reversible NAD+-dependent-dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments in both plants and mammals.", "Plant tissues contain multiple isoforms of malate dehydrogenase (1-malate-NAD-oxidoreductase [MDH]; EC 1.1.1.37) that catalyze the interconversion of malate and oxaloacetate (OAA) coupled to reduction or oxidation of the NAD pool.", "Notably, OAA is readily transported both into and out of isolated plant mitochondria, in contrast to mammalian mitochondria, which are essentially impermeable to this organic acid.", "MDH-mutant plants exhibit either no obvious phenotype or slower growth rates and altered photorespiratory characteristics.", "See, e.g., Tomaz et al., (2010) Plant Physiol.", "154(3):1143-1157, Goodman, M. M., Newton K. J. and Stuber, C. W. (1981) Proc.", "Nat.", "Acad.", "Sci.", "USA 78:1783-1785 or Imsande, J. et al., (2001) J. Heredity 92:333-338 and U.S. Patent Publication No.", "2009/0123626 describes the use of MDH antisense to reduce asparagine levels, which in turn lowers the level of acrylamide that accumulates upon processing-associated heating of the plant and plant products.", "Thus, the methods and compositions of the invention may be used to disrupt a malate dehydrogenase (MDH) with a CRISPR/Cas system where the single guide RNA comprises sequences to target a MDH gene.", "The CRISPR/Cas system comprises an engineered sgRNA (or its equivalent) to target desired locations in a genome.", "Only 12 base pairs of this guide RNA and 2 base pairs of the PAM sequence (14 base pairs total) appear to be critical for CRISPR/Cas activity.", "Assuming the CRISPR/Cas construct is absolutely specific for these 14 base pairs, we would expect such a construct to cleave approximately 20 times in the human genome since a given 14 nucleotide sequence will occur approximately once every 268,435,456 (414) nucleotides, the haploid human genome contains approximately 3,000,000,000 nucleotides, and the 14 nucleotide sequence can be on either of the two strands of the genome.", "This figure also requires absolute specificity of recognition.", "So the actual number of off target cleavage sites could be higher.", "The instant invention provides methods and compositions to increase the target size of the CRISPR/Cas system to increase its specificity.", "The Cas nuclease comprises two nuclease domains, the HNH and RuvC-like, for cleaving the sense and the antisense strands of the target DNA, respectively.", "The Cas nuclease can thus be engineered such that only one of the nuclease domains is functional, thus creating a Cas nickase (see Jinek, ibid).", "Nickases can be generated by specific mutation of amino acids in the catalytic domain of the enzyme, or by truncation of part or all of the domain such that it is no longer functional.", "Since Cas comprises two nuclease domains, this approach may be taken on either domain.", "A double strand break can be achieved in the target DNA by the use of two such Cas nickases.", "The nickases will each cleave one strand of the DNA and the use of two will create a double strand break.", "Thus, specificity of the system is increased greatly by using two Cas nickase proteins because the target length is increased from 12-14 nucleotides to 24-28 nucleotides (not including the spacer in between the two subtargets).", "Using this approach, the expected number of perfectly matched off-target sites in a human genome drops by a factor or 414, from ˜20 (as described above) to ˜<10−7 (assuming a 28 base pair DNA recognized by the CRISPR/Cas nickase dimer).", "General Practice of the methods, as well as preparation and use of the compositions disclosed herein employ, unless otherwise indicated, conventional techniques in molecular biology, biochemistry, chromatin structure and analysis, computational chemistry, cell culture, recombinant DNA and related fields as are within the skill of the art.", "These techniques are fully explained in the literature.", "See, for example, Sambrook et al., MOLECULAR CLONING: A LABORATORY MANUAL, Second edition, Cold Spring Harbor Laboratory Press, 1989 and Third edition, 2001; Ausubel et al., CURRENT PROTOCOLS IN MOLECULAR BIOLOGY, John Wiley & Sons, New York, 1987 and periodic updates; the series METHODS IN ENZYMOLOGY, Academic Press, San Diego; Wolfe, CHROMATIN STRUCTURE AND FUNCTION, Third edition, Academic Press, San Diego, 1998; METHODS IN ENZYMOLOGY, Vol.", "304, “Chromatin” (P. M. Wassarman and A. P. Wolffe, eds.", "), Academic Press, San Diego, 1999; and METHODS IN MOLECULAR BIOLOGY, Vol.", "119, “Chromatin Protocols” (P. B. Becker, ed.)", "Humana Press, Totowa, 1999.Definitions The terms “nucleic acid,” “polynucleotide,” and “oligonucleotide” are used interchangeably and refer to a deoxyribonucleotide or ribonucleotide polymer, in linear or circular conformation, and in either single- or double-stranded form.", "For the purposes of the present disclosure, these terms are not to be construed as limiting with respect to the length of a polymer.", "The terms can encompass known analogues of natural nucleotides, as well as nucleotides that are modified in the base, sugar and/or phosphate moieties (e.g., phosphorothioate backbones).", "In general, an analogue of a particular nucleotide has the same base-pairing specificity; i.e., an analogue of A will base-pair with T. The terms “polypeptide,” “peptide” and “protein” are used interchangeably to refer to a polymer of amino acid residues.", "The term also applies to amino acid polymers in which one or more amino acids are chemical analogues or modified derivatives of corresponding naturally-occurring amino acids.", "“Binding” refers to a sequence-specific, non-covalent interaction between macromolecules (e.g., between a protein and a nucleic acid or between two nucleic acids).", "Not all components of a binding interaction need be sequence-specific (e.g., contacts with phosphate residues in a DNA backbone), as long as the interaction as a whole is sequence-specific.", "Such interactions are generally characterized by a dissociation constant (Kd) of 10−6 M−1 or lower.", "“Affinity” refers to the strength of binding: increased binding affinity being correlated with a lower Kd.", "The terms “chimeric RNA”, “chimeric guide RNA”, “guide RNA”, “single guide RNA” and “synthetic guide RNA” are used interchangeably and refer to the polynucleotide sequence comprising the guide sequence, the tracr sequence and the tracr mate sequence.", "The term “guide sequence” refers to the about 10-30 (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30) base pair sequence within the guide RNA that specifies the target site and may be used interchangeably with the terms “guide” or “spacer”.", "The term “tracr mate sequence” may also be used interchangeably with the term “direct repeat(s)”.", "“Complementarity” refers to the ability of a nucleic acid to form hydrogen bond(s) with another nucleic acid sequence by either traditional Watson-Crick or other non-traditional types.", "A percent complementarity indicates the percentage of residues in a nucleic acid molecule which can form hydrogen bonds (e.g., Watson-Crick base pairing) with a second nucleic acid sequence (e.g., 5, 6, 7, 8, 9, 10 out of 10 being 50%, 60%, 70%, 80%, 90%, and 100% complementary).", "“Perfectly complementary” means that all the contiguous residues of a nucleic acid sequence will hydrogen bond with the same number of contiguous residues in a second nucleic acid sequence.", "“Substantially complementary” as used herein refers to a degree of complementarity that is at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%.", "97%, 98%, 99%, or 100% over a region of 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 30, 35, 40, 45, 50, or more nucleotides, or refers to two nucleic acids that hybridize under stringent conditions.", "A “binding protein” is a protein that is able to bind to another molecule.", "A binding protein can bind to, for example, a DNA molecule (a DNA-binding protein), an RNA molecule (an RNA-binding protein) and/or a protein molecule (a protein-binding protein).", "In the case of a protein-binding protein, it can bind to itself (to form homodimers, homotrimers, etc.)", "and/or it can bind to one or more molecules of a different protein or proteins.", "A binding protein can have more than one type of binding activity.", "For example, zinc finger proteins have DNA-binding, RNA-binding and protein-binding activity.", "A “zinc finger DNA binding protein” (or binding domain) is a protein, or a domain within a larger protein, that binds DNA in a sequence-specific manner through one or more zinc fingers, which are regions of amino acid sequence within the binding domain whose structure is stabilized through coordination of a zinc ion.", "The term zinc finger DNA binding protein is often abbreviated as zinc finger protein or ZFP.", "A “TALE DNA binding domain” or “TALE” is a polypeptide comprising one or more TALE repeat domains/units.", "The repeat domains are involved in binding of the TALE to its cognate target DNA sequence.", "A single “repeat unit” (also referred to as a “repeat”) is typically 33-35 amino acids in length and exhibits at least some sequence homology with other TALE repeat sequences within a naturally occurring TALE protein.", "Zinc finger and TALE binding domains can be “engineered” to bind to a predetermined nucleotide sequence, for example via engineering (altering one or more amino acids) of the recognition helix region of a naturally occurring zinc finger or TALE protein.", "Therefore, engineered DNA binding proteins (zinc fingers or TALEs) are proteins that are non-naturally occurring.", "Non-limiting examples of methods for engineering DNA-binding proteins are design and selection.", "A designed DNA binding protein is a protein not occurring in nature whose design/composition results principally from rational criteria.", "Rational criteria for design include application of substitution rules and computerized algorithms for processing information in a database storing information of existing ZFP and/or TALE designs and binding data.", "See, for example, U.S. Pat.", "Nos.", "8,586,526; 6,140,081; 6,453,242; and 6,534,261; see also International Patent Publication Nos.", "WO 98/53058; WO 98/53059; WO 98/53060; WO 02/016536; and WO 03/016496.A “selected” zinc finger protein or TALE is a protein not found in nature whose production results primarily from an empirical process such as phage display, interaction trap or hybrid selection.", "See e.g., U.S. Pat.", "Nos.", "8,586,526; 5,789,538; 5,925,523; 6,007,988; 6,013,453; 6,200,759; as well as International Patent Publication Nos.", "WO 95/19431; WO 96/06166; WO 98/53057; WO 98/54311; WO 00/27878; WO 01/60970; WO 01/88197; and WO 02/099084.“Recombination” refers to a process of exchange of genetic information between two polynucleotides.", "For the purposes of this disclosure, “homologous recombination (HR)” refers to the specialized form of such exchange that takes place, for example, during repair of double-strand breaks in cells via homology-directed repair mechanisms.", "This process requires nucleotide sequence homology, uses a “donor” molecule to template repair of a “target” molecule (i.e., the one that experienced the double-strand break), and is variously known as “non-crossover gene conversion” or “short tract gene conversion,” because it leads to the transfer of genetic information from the donor to the target.", "Without wishing to be bound by any particular theory, such transfer can involve mismatch correction of heteroduplex DNA that forms between the broken target and the donor, and/or “synthesis-dependent strand annealing,” in which the donor is used to re-synthesize genetic information that will become part of the target, and/or related processes.", "Such specialized HR often results in an alteration of the sequence of the target molecule such that part or all of the sequence of the donor polynucleotide is incorporated into the target polynucleotide.", "In the methods of the disclosure, one or more targeted nucleases (e.g., CRISPR/Cas) as described herein create a double-stranded break in the target sequence (e.g., cellular chromatin) at a predetermined site, and a “donor” polynucleotide, having homology to the nucleotide sequence in the region of the break, can be introduced into the cell.", "The presence of the double-stranded break has been shown to facilitate integration of the donor sequence.", "The donor sequence may be physically integrated or, alternatively, the donor polynucleotide is used as a template for repair of the break via homologous recombination, resulting in the introduction of all or part of the nucleotide sequence as in the donor into the cellular chromatin.", "Thus, a first sequence in cellular chromatin can be altered and, in certain embodiments, can be converted into a sequence present in a donor polynucleotide.", "Thus, the use of the terms “replace” or “replacement” can be understood to represent replacement of one nucleotide sequence by another, (i.e., replacement of a sequence in the informational sense), and does not necessarily require physical or chemical replacement of one polynucleotide by another.", "In any of the methods described herein, additional CRISPR/Cas nucleases and/or additional pairs of zinc-finger or TALEN proteins can be used for additional double-stranded cleavage of additional target sites within the cell.", "In certain embodiments of methods for targeted recombination and/or replacement and/or alteration of a sequence in a region of interest in cellular chromatin, a chromosomal sequence is altered by homologous recombination with an exogenous “donor” nucleotide sequence.", "Such homologous recombination is stimulated by the presence of a double-stranded break in cellular chromatin, if sequences homologous to the region of the break are present.", "In any of the methods described herein, the exogenous nucleotide sequence (the “donor sequence” or “transgene”) can contain sequences that are homologous, but not identical, to genomic sequences in the region of interest, thereby stimulating homologous recombination to insert a non-identical sequence in the region of interest.", "Thus, in certain embodiments, portions of the donor sequence that are homologous to sequences in the region of interest exhibit between about 80 to 99% (or any integer therebetween) sequence identity to the genomic sequence that is replaced.", "In other embodiments, the homology between the donor and genomic sequence is higher than 99%, for example if only 1 nucleotide differs as between donor and genomic sequences of over 100 contiguous base pairs.", "In certain cases, a non-homologous portion of the donor sequence can contain sequences not present in the region of interest, such that new sequences are introduced into the region of interest.", "In these instances, the non-homologous sequence is generally flanked by sequences of 50-1,000 base pairs (or any integral value therebetween) or any number of base pairs greater than 1,000, that are homologous or identical to sequences in the region of interest.", "In other embodiments, the donor sequence is non-homologous to the first sequence, and is inserted into the genome by non-homologous recombination mechanisms.", "Any of the methods described herein can be used for partial or complete inactivation of one or more target sequences in a cell by targeted integration of donor sequence that disrupts expression of the gene(s) of interest.", "Cell lines with partially or completely inactivated genes are also provided.", "Furthermore, the methods of targeted integration as described herein can also be used to integrate one or more exogenous sequences.", "The exogenous nucleic acid sequence can comprise, for example, one or more genes or cDNA molecules, or any type of coding or non-coding sequence, as well as one or more control elements (e.g., promoters).", "In addition, the exogenous nucleic acid sequence may produce one or more RNA molecules (e.g., small hairpin RNAs (shRNAs), inhibitory RNAs (RNAis), microRNAs (miRNAs), etc.).", "“Cleavage” refers to the breakage of the covalent backbone of a DNA molecule.", "Cleavage can be initiated by a variety of methods including, but not limited to, enzymatic or chemical hydrolysis of a phosphodiester bond.", "Both single-stranded cleavage and double-stranded cleavage are possible, and double-stranded cleavage can occur as a result of two distinct single-stranded cleavage events.", "DNA cleavage can result in the production of either blunt ends or staggered ends.", "In certain embodiments, fusion polypeptides are used for targeted double-stranded DNA cleavage.", "A “cleavage half-domain” is a polypeptide sequence which, in conjunction with a second polypeptide (either identical or different) forms a complex having cleavage activity (preferably double-strand cleavage activity).", "The terms “first and second cleavage half-domains;” “+ and − cleavage half-domains” and “right and left cleavage half-domains” are used interchangeably to refer to pairs of cleavage half-domains that dimerize.", "An “engineered cleavage half-domain” is a cleavage half-domain that has been modified so as to form obligate heterodimers with another cleavage half-domain (e.g., another engineered cleavage half-domain).", "See, also, U.S. Patent Publication Nos.", "2005/0064474; 2007/0218528; 2008/0131962; and 2011/0201055, incorporated herein by reference in their entireties.", "The term “sequence” refers to a nucleotide sequence of any length, which can be DNA or RNA; can be linear, circular or branched and can be either single-stranded or double stranded.", "The term “donor sequence” refers to a nucleotide sequence that is inserted into a genome.", "A donor sequence can be of any length, for example between 2 and 10,000 nucleotides in length (or any integer value therebetween or thereabove), preferably between about 100 and 1,000 nucleotides in length (or any integer therebetween), more preferably between about 200 and 500 nucleotides in length.", "A “homologous, non-identical sequence” refers to a first sequence which shares a degree of sequence identity with a second sequence, but whose sequence is not identical to that of the second sequence.", "For example, a polynucleotide comprising the wild-type sequence of a mutant gene is homologous and non-identical to the sequence of the mutant gene.", "In certain embodiments, the degree of homology between the two sequences is sufficient to allow homologous recombination therebetween, utilizing normal cellular mechanisms.", "Two homologous non-identical sequences can be any length and their degree of non-homology can be as small as a single nucleotide (e.g., for correction of a genomic point mutation by targeted homologous recombination) or as large as 10 or more kilobases (e.g., for insertion of a gene at a predetermined ectopic site in a chromosome).", "Two polynucleotides comprising the homologous non-identical sequences need not be the same length.", "For example, an exogenous polynucleotide (i.e., donor polynucleotide) of between 20 and 10,000 nucleotides or nucleotide pairs can be used.", "Techniques for determining nucleic acid and amino acid sequence identity are known in the art.", "Typically, such techniques include determining the nucleotide sequence of the mRNA for a gene and/or determining the amino acid sequence encoded thereby, and comparing these sequences to a second nucleotide or amino acid sequence.", "Genomic sequences can also be determined and compared in this fashion.", "In general, identity refers to an exact nucleotide-to-nucleotide or amino acid-to-amino acid correspondence of two polynucleotides or polypeptide sequences, respectively.", "Two or more sequences (polynucleotide or amino acid) can be compared by determining their percent identity.", "The percent identity of two sequences, whether nucleic acid or amino acid sequences, is the number of exact matches between two aligned sequences divided by the length of the shorter sequences and multiplied by 100.An approximate alignment for nucleic acid sequences is provided by the local homology algorithm of Smith and Waterman, Advances in Applied Mathematics 2:482-489 (1981).", "This algorithm can be applied to amino acid sequences by using the scoring matrix developed by Dayhoff, Atlas of Protein Sequences and Structure, M. O. Dayhoff ed., 5 suppl.", "3:353-358, National Biomedical Research Foundation, Washington, D.C., USA, and normalized by Gribskov, Nucl.", "Acids Res.", "14(6):6745-6763 (1986).", "An exemplary implementation of this algorithm to determine percent identity of a sequence is provided by the Genetics Computer Group (Madison, Wis.) in the “BestFit” utility application.", "Suitable programs for calculating the percent identity or similarity between sequences are generally known in the art, for example, another alignment program is BLAST, used with default parameters.", "For example, BLASTN and BLASTP can be used using the following default parameters: genetic code=standard; filter=none; strand=both; cutoff=60; expect=10; Matrix=BLOSUM62; Descriptions=50 sequences; sort by=HIGH SCORE; Databases=non-redundant, GenBank+EMBL+DDBJ+PDB+GenBank CDS translations+Swiss protein+Spupdate+PIR.", "Details of these programs can be found on the internet.", "With respect to sequences described herein, the range of desired degrees of sequence identity is approximately 80% to 100% and any integer value therebetween.", "Typically the percent identities between sequences are at least 70-75%, preferably 80-82%, more preferably 85-90%, even more preferably 92%, still more preferably 95%, and most preferably 98% sequence identity.", "Alternatively, the degree of sequence similarity between polynucleotides can be determined by hybridization of polynucleotides under conditions that allow formation of stable duplexes between homologous regions, followed by digestion with single-stranded-specific nuclease(s), and size determination of the digested fragments.", "Two nucleic acid, or two polypeptide sequences are substantially homologous to each other when the sequences exhibit at least about 70%-75%, preferably 80%-82%, more preferably 85%-90%, even more preferably 92%, still more preferably 95%, and most preferably 98% sequence identity over a defined length of the molecules, as determined using the methods above.", "As used herein, substantially homologous also refers to sequences showing complete identity to a specified DNA or polypeptide sequence.", "DNA sequences that are substantially homologous can be identified in a Southern hybridization experiment under, for example, stringent conditions, as defined for that particular system.", "Defining appropriate hybridization conditions is known to those with skill of the art.", "See, e.g., Sambrook et al., supra; Nucleic Acid Hybridization: A Practical Approach, editors B. D. Hames and S. J. Higgins, (1985) Oxford; Washington, D.C.; IRL Press).", "Selective hybridization of two nucleic acid fragments can be determined as follows.", "The degree of sequence identity between two nucleic acid molecules affects the efficiency and strength of hybridization events between such molecules.", "A partially identical nucleic acid sequence will at least partially inhibit the hybridization of a completely identical sequence to a target molecule.", "Inhibition of hybridization of the completely identical sequence can be assessed using hybridization assays that are well known in the art (e.g., Southern (DNA) blot, Northern (RNA) blot, solution hybridization, or the like, see Sambrook, et al., Molecular Cloning: A Laboratory Manual, Second Edition, (1989) Cold Spring Harbor, N.Y.).", "Such assays can be conducted using varying degrees of selectivity, for example, using conditions varying from low to high stringency.", "If conditions of low stringency are employed, the absence of non-specific binding can be assessed using a secondary probe that lacks even a partial degree of sequence identity (for example, a probe having less than about 30% sequence identity with the target molecule), such that, in the absence of non-specific binding events, the secondary probe will not hybridize to the target.", "When utilizing a hybridization-based detection system, a nucleic acid probe is chosen that is complementary to a reference nucleic acid sequence, and then by selection of appropriate conditions the probe and the reference sequence selectively hybridize, or bind, to each other to form a duplex molecule.", "A nucleic acid molecule that is capable of hybridizing selectively to a reference sequence under moderately stringent hybridization conditions typically hybridizes under conditions that allow detection of a target nucleic acid sequence of at least about 10-14 nucleotides in length having at least approximately 70% sequence identity with the sequence of the selected nucleic acid probe.", "Stringent hybridization conditions typically allow detection of target nucleic acid sequences of at least about 10-14 nucleotides in length having a sequence identity of greater than about 90-95% with the sequence of the selected nucleic acid probe.", "Hybridization conditions useful for probe/reference sequence hybridization, where the probe and reference sequence have a specific degree of sequence identity, can be determined as is known in the art (see, for example, Nucleic Acid Hybridization: A Practical Approach, editors B. D. Hames and S. J. Higgins, (1985) Oxford; Washington, D.C.; IRL Press).", "Conditions for hybridization are well-known to those of skill in the art.", "Hybridization stringency refers to the degree to which hybridization conditions disfavor the formation of hybrids containing mismatched nucleotides, with higher stringency correlated with a lower tolerance for mismatched hybrids.", "Factors that affect the stringency of hybridization are well-known to those of skill in the art and include, but are not limited to, temperature, pH, ionic strength, and concentration of organic solvents such as, for example, formamide and dimethylsulfoxide.", "As is known to those of skill in the art, hybridization stringency is increased by higher temperatures, lower ionic strength and lower solvent concentrations.", "With respect to stringency conditions for hybridization, it is well known in the art that numerous equivalent conditions can be employed to establish a particular stringency by varying, for example, the following factors: the length and nature of the probe sequences, base composition of the various sequences, concentrations of salts and other hybridization solution components, the presence or absence of blocking agents in the hybridization solutions (e.g., dextran sulfate, and polyethylene glycol), hybridization reaction temperature and time parameters, as well as, varying wash conditions.", "The selection of a particular set of hybridization conditions is selected following standard methods in the art (see, for example, Sambrook, et al., Molecular Cloning: A Laboratory Manual, Second Edition, (1989) Cold Spring Harbor, N.Y.).", "“Chromatin” is the nucleoprotein structure comprising the cellular genome.", "Cellular chromatin comprises nucleic acid, primarily DNA, and protein, including histones and non-histone chromosomal proteins.", "The majority of eukaryotic cellular chromatin exists in the form of nucleosomes, wherein a nucleosome core comprises approximately 150 base pairs of DNA associated with an octamer comprising two each of histones H2A, H2B, H3 and H4; and linker DNA (of variable length depending on the organism) extends between nucleosome cores.", "A molecule of histone H1 is generally associated with the linker DNA.", "For the purposes of the present disclosure, the term “chromatin” is meant to encompass all types of cellular nucleoprotein, both prokaryotic and eukaryotic.", "Cellular chromatin includes both chromosomal and episomal chromatin.", "A “chromosome,” is a chromatin complex comprising all or a portion of the genome of a cell.", "The genome of a cell is often characterized by its karyotype, which is the collection of all the chromosomes that comprise the genome of the cell.", "The genome of a cell can comprise one or more chromosomes.", "An “episome” is a replicating nucleic acid, nucleoprotein complex or other structure comprising a nucleic acid that is not part of the chromosomal karyotype of a cell.", "Examples of episomes include plasmids and certain viral genomes.", "An “accessible region” is a site in cellular chromatin in which a target site present in the nucleic acid can be bound by an exogenous molecule which recognizes the target site.", "Without wishing to be bound by any particular theory, it is believed that an accessible region is one that is not packaged into a nucleosomal structure.", "The distinct structure of an accessible region can often be detected by its sensitivity to chemical and enzymatic probes, for example, nucleases.", "A “target site” or “target sequence” is a nucleic acid sequence that defines a portion of a nucleic acid to which a binding molecule will bind, provided sufficient conditions for binding exist.", "An “exogenous” molecule is a molecule that is not normally present in a cell, but can be introduced into a cell by one or more genetic, biochemical or other methods.", "“Normal presence in the cell” is determined with respect to the particular developmental stage and environmental conditions of the cell.", "Thus, for example, a molecule that is present only during embryonic development of muscle is an exogenous molecule with respect to an adult muscle cell.", "Similarly, a molecule induced by heat shock is an exogenous molecule with respect to a non-heat-shocked cell.", "An exogenous molecule can comprise, for example, a functioning version of a malfunctioning endogenous molecule or a malfunctioning version of a normally-functioning endogenous molecule.", "An exogenous molecule can be, among other things, a small molecule, such as is generated by a combinatorial chemistry process, or a macromolecule such as a protein, nucleic acid, carbohydrate, lipid, glycoprotein, lipoprotein, polysaccharide, any modified derivative of the above molecules, or any complex comprising one or more of the above molecules.", "Nucleic acids include DNA and RNA, can be single- or double-stranded; can be linear, branched or circular; and can be of any length.", "Nucleic acids include those capable of forming duplexes, as well as triplex-forming nucleic acids.", "See, for example, U.S. Pat.", "Nos.", "5,176,996 and 5,422,251.Proteins include, but are not limited to, DNA-binding proteins, transcription factors, chromatin remodeling factors, methylated DNA binding proteins, polymerases, methylases, demethylases, acetylases, deacetylases, kinases, phosphatases, integrases, recombinases, ligases, topoisomerases, gyrases and helicases.", "Thus, the term includes “transgenes” or “genes of interest” which are exogenous sequences introduced into a cell.", "An exogenous molecule can be the same type of molecule as an endogenous molecule, e.g., an exogenous protein or nucleic acid.", "For example, an exogenous nucleic acid can comprise an infecting viral genome, a plasmid or episome introduced into a cell, or a chromosome that is not normally present in the cell.", "Methods for the introduction of exogenous molecules into cells are known to those of skill in the art and include, but are not limited to, lipid-mediated transfer (i.e., liposomes, including neutral and cationic lipids), electroporation, direct injection, cell fusion, particle bombardment, calcium phosphate co-precipitation, DEAE-dextran-mediated transfer and viral vector-mediated transfer.", "An exogenous molecule can also be the same type of molecule as an endogenous molecule but derived from a different species than the cell is derived from.", "For example, a human nucleic acid sequence may be introduced into a cell line originally derived from a mouse or hamster.", "Methods for the introduction of exogenous molecules into plant cells are known to those of skill in the art and include, but are not limited to, protoplast transformation, silicon carbide (e.g., WHISKERS™) Agrobacterium-mediated transformation, lipid-mediated transfer (i.e., liposomes, including neutral and cationic lipids), electroporation, direct injection, cell fusion, particle bombardment (e.g., using a “gene gun”), calcium phosphate co-precipitation, DEAE-dextran-mediated transfer and viral vector-mediated transfer.", "By contrast, an “endogenous” molecule is one that is normally present in a particular cell at a particular developmental stage under particular environmental conditions.", "For example, an endogenous nucleic acid can comprise a chromosome, the genome of a mitochondrion, chloroplast or other organelle, or a naturally-occurring episomal nucleic acid.", "Additional endogenous molecules can include proteins, for example, transcription factors and enzymes.", "As used herein, the term “product of an exogenous nucleic acid” includes both polynucleotide and polypeptide products, for example, transcription products (polynucleotides such as RNA) and translation products (polypeptides).", "A “fusion” molecule is a molecule in which two or more subunit molecules are linked, preferably covalently.", "The subunit molecules can be the same chemical type of molecule, or can be different chemical types of molecules.", "Examples of the first type of fusion molecule include, but are not limited to, fusion proteins (for example, a fusion between a ZFP or TALE DNA-binding domain and one or more activation domains) and fusion nucleic acids (for example, a nucleic acid encoding the fusion protein described supra).", "Examples of the second type of fusion molecule include, but are not limited to, a fusion between a triplex-forming nucleic acid and a polypeptide, and a fusion between a minor groove binder and a nucleic acid.", "A “fusion polypeptide” is a polypeptide comprising a polypeptide or portion (e.g., one or more domains) thereof fused or bonded to heterologous polypeptide.", "Examples of fusion polypeptides include immunoadhesins which combine a portion of the Cas protein with an immunoglobulin sequence, and epitope tagged polypeptides, which may comprise a Cas protein, for example, or portion thereof fused to a “tag polypeptide”.", "The tag polypeptide has enough residues to provide an epitope against which an antibody can be made, yet is short enough such that it does not interfere with nuclease activity of Cas.", "Suitable tag polypeptides generally have at least six amino acid residues and usually between about 6-60 amino acid residues.", "Expression of a fusion protein in a cell can result from delivery of the fusion protein to the cell or by delivery of a polynucleotide encoding the fusion protein to a cell, wherein the polynucleotide is transcribed, and the transcript is translated, to generate the fusion protein.", "Trans-splicing, polypeptide cleavage and polypeptide ligation can also be involved in expression of a protein in a cell.", "Methods for polynucleotide and polypeptide delivery to cells are presented elsewhere in this disclosure.", "A “gene,” for the purposes of the present disclosure, includes a DNA region encoding a gene product (see infra), as well as all DNA regions which regulate the production of the gene product, whether or not such regulatory sequences are adjacent to coding and/or transcribed sequences.", "Accordingly, a gene includes, but is not necessarily limited to, promoter sequences, terminators, translational regulatory sequences such as ribosome binding sites and internal ribosome entry sites, enhancers, silencers, insulators, boundary elements, replication origins, matrix attachment sites and locus control regions.", "An “engineered gene” refers to a gene which has been altered in some manner such that it is non-identical with a wild type gene.", "Alterations can be in the form of targeted deletions, insertions and truncations.", "An engineered gene can comprise coding sequences from two heterologous genes or may comprise synthetic gene sequences.", "An engineered gene may also comprise changes in the coding sequence that are silent in the protein sequence (e.g.", "codon optimization).", "An engineered gene can also comprise a gene with altered regulatory sequences.", "“Gene expression” refers to the conversion of the information, contained in a gene, into a gene product.", "A gene product can be the direct transcriptional product of a gene (e.g., mRNA, tRNA, rRNA, antisense RNA, ribozyme, structural RNA or any other type of RNA) or a protein produced by translation of an mRNA.", "Gene products also include RNAs which are modified, by processes such as capping, polyadenylation, methylation, and editing, and proteins modified by, for example, methylation, acetylation, phosphorylation, ubiquitination, ADP-ribosylation, myristilation, and glycosylation.", "“Modulation” of gene expression refers to a change in the activity of a gene.", "Modulation of expression can include, but is not limited to, gene activation and gene repression.", "Genome editing (e.g., cleavage, alteration, inactivation, random mutation) can be used to modulate expression.", "Gene inactivation refers to any reduction in gene expression as compared to a cell that does not include a CRISPR/Cas system as described herein.", "Thus, gene inactivation may be partial or complete.", "“Plant” cells include, but are not limited to, cells of monocotyledonous (monocots) or dicotyledonous (dicots) plants.", "Non-limiting examples of monocots include cereal plants such as maize, rice, barley, oats, wheat, sorghum, rye, sugarcane, pineapple, onion, banana, and coconut.", "Non-limiting examples of dicots include tobacco, tomato, sunflower, cotton, sugarbeet, potato, lettuce, melon, soy, canola (rapeseed), and alfalfa.", "Plant cells may be from any part of the plant and/or from any stage of plant development.", "A “region of interest” is any region of cellular chromatin, such as, for example, a gene or a non-coding sequence within or adjacent to a gene, in which it is desirable to bind an exogenous molecule.", "Binding can be for the purposes of targeted DNA cleavage and/or targeted recombination.", "A region of interest can be present in a chromosome, an episome, an organellar genome (e.g., mitochondrial, chloroplast), or an infecting viral genome, for example.", "A region of interest can be within the coding region of a gene, within transcribed non-coding regions such as, for example, leader sequences, trailer sequences or introns, or within non-transcribed regions, either upstream or downstream of the coding region.", "A region of interest can be as small as a single nucleotide pair or up to 2,000 nucleotide pairs in length, or any integral value of nucleotide pairs.", "“Eukaryotic” cells include, but are not limited to, fungal cells (such as yeast), plant cells, animal cells, mammalian cells and human cells (e.g., T-cells).", "“Red Blood Cells” (RBCs), or erythrocytes, are terminally differentiated cells derived from hematopoietic stem cells.", "They lack a nuclease and most cellular organelles.", "RBCs contain hemoglobin to carry oxygen from the lungs to the peripheral tissues.", "In fact, 33% of an individual RBC is hemoglobin.", "They also carry CO2 produced by cells during metabolism out of the tissues and back to the lungs for release during exhale.", "RBCs are produced in the bone marrow in response to blood hypoxia which is mediated by release of erythropoietin (EPO) by the kidney.", "EPO causes an increase in the number of proerythroblasts and shortens the time required for full RBC maturation.", "After approximately 120 days, since the RBC do not contain a nucleus or any other regenerative capabilities, the cells are removed from circulation by either the phagocytic activities of macrophages in the liver, spleen and lymph nodes (˜90%) or by hemolysis in the plasma (˜10%).", "Following macrophage engulfment, chemical components of the RBC are broken down within vacuoles of the macrophages due to the action of lysosomal enzymes.", "“Secretory tissues” are those tissues in an animal that secrete products out of the individual cell into a lumen of some type which are typically derived from epithelium.", "Examples of secretory tissues that are localized to the gastrointestinal tract include the cells that line the gut, the pancreas, and the gallbladder.", "Other secretory tissues include the liver, tissues associated with the eye and mucous membranes such as salivary glands, mammary glands, the prostate gland, the pituitary gland and other members of the endocrine system.", "Additionally, secretory tissues include individual cells of a tissue type which are capable of secretion.", "The terms “operative linkage” and “operatively linked” (or “operably linked”) are used interchangeably with reference to a juxtaposition of two or more components (such as sequence elements), in which the components are arranged such that both components function normally and allow the possibility that at least one of the components can mediate a function that is exerted upon at least one of the other components.", "By way of illustration, a transcriptional regulatory sequence, such as a promoter, is operatively linked to a coding sequence if the transcriptional regulatory sequence controls the level of transcription of the coding sequence in response to the presence or absence of one or more transcriptional regulatory factors.", "A transcriptional regulatory sequence is generally operatively linked in cis with a coding sequence, but need not be directly adjacent to it.", "For example, an enhancer is a transcriptional regulatory sequence that is operatively linked to a coding sequence, even though they are not contiguous.", "With respect to fusion polypeptides, the term “operatively linked” can refer to the fact that each of the components performs the same function in linkage to the other component as it would if it were not so linked.", "For example, with respect to a fusion polypeptide in which a Cas DNA-binding domain is fused to an activation domain, the Cas DNA-binding domain and the activation domain are in operative linkage if, in the fusion polypeptide, the Cas DNA-binding domain portion is able to bind its target site and/or its binding site, while the activation domain is able to up-regulate gene expression.", "When a fusion polypeptide in which a Cas DNA-binding domain is fused to a cleavage domain, the Cas DNA-binding domain and the cleavage domain are in operative linkage if, in the fusion polypeptide, the Cas DNA-binding domain portion is able to bind its target site and/or its binding site, while the cleavage domain is able to cleave DNA in the vicinity of the target site.", "A “functional fragment” of a protein, polypeptide or nucleic acid is a protein, polypeptide or nucleic acid whose sequence is not identical to the full-length protein, polypeptide or nucleic acid, yet retains the same function as the full-length protein, polypeptide or nucleic acid.", "A functional fragment can possess more, fewer, or the same number of residues as the corresponding native molecule, and/or can contain one or more amino acid or nucleotide substitutions.", "Methods for determining the function of a nucleic acid (e.g., coding function, ability to hybridize to another nucleic acid) are well-known in the art.", "Similarly, methods for determining protein function are well-known.", "For example, the DNA-binding function of a polypeptide can be determined, for example, by filter-binding, electrophoretic mobility-shift, or immunoprecipitation assays.", "DNA cleavage can be assayed by gel electrophoresis.", "See Ausubel et al., supra.", "The ability of a protein to interact with another protein can be determined, for example, by co-immunoprecipitation, two-hybrid assays or complementation, both genetic and biochemical.", "See, for example, Fields et al., (1989) Nature 340:245-246; U.S. Pat.", "No.", "5,585,245 and International Patent Publication No.", "WO 98/44350.A “vector” is capable of transferring gene sequences to target cells.", "Typically, “vector construct,” “expression vector,” and “gene transfer vector,” mean any nucleic acid construct capable of directing the expression of a gene of interest and which can transfer gene sequences to target cells.", "Thus, the term includes cloning, and expression vehicles, as well as integrating vectors.", "A “reporter gene” or “reporter sequence” refers to any sequence that produces a protein product that is easily measured, preferably although not necessarily in a routine assay.", "Suitable reporter genes include, but are not limited to, sequences encoding proteins that mediate antibiotic resistance (e.g., ampicillin resistance, neomycin resistance, G418 resistance, puromycin resistance), sequences encoding colored or fluorescent or luminescent proteins (e.g., green fluorescent protein, enhanced green fluorescent protein, red fluorescent protein, luciferase), and proteins which mediate enhanced cell growth and/or gene amplification (e.g., dihydrofolate reductase).", "Epitope tags include, for example, one or more copies of FLAG, His, myc, Tap, HA or any detectable amino acid sequence.", "“Expression tags” include sequences that encode reporters that may be operably linked to a desired gene sequence in order to monitor expression of the gene of interest.", "The terms “subject” and “patient” are used interchangeably and refer to mammals such as human patients and non-human primates, as well as experimental animals such as rabbits, dogs, cats, rats, mice, and other animals.", "Accordingly, the term “subject” or “patient” as used herein means any mammalian patient or subject to which the or stem cells of the invention can be administered.", "Subjects of the present invention include those that have been exposed to one or more chemical toxins, including, for example, a nerve toxin.", "The CRISPR/Cas System Compelling evidence has recently emerged for the existence of an RNA-mediated genome defense pathway in archaea and many bacteria that has been hypothesized to parallel the eukaryotic RNAi pathway (for reviews, see Godde and Bickerton, 2006.J.", "Mol.", "Evol.", "62: 718-729; Lillestol et al., 2006.Archaea 2: 59-72; Makarova et al., 2006.Biol.", "Direct 1: 7.; Sorek et al., 2008.Nat.", "Rev.", "Microbiol.", "6: 181-186).", "Known as the CRISPR-Cas system or prokaryotic RNAi (pRNAi), the pathway is proposed to arise from two evolutionarily and often physically linked gene loci: the CRISPR (clustered regularly interspaced short palindromic repeats) locus, which encodes RNA components of the system, and the cas (CRISPR-associated) locus, which encodes proteins (Jansen et al., 2002.Mol.", "Microbiol.", "43: 1565-1575; Makarova et al., 2002.Nucleic Acids Res.", "30: 482-496; Makarova et al., 2006.Biol.", "Direct 1: 7; Haft et al., 2005.PLoS Comput.", "Biol.", "1: e60).", "CRISPR loci in microbial hosts contain a combination of CRISPR-associated (Cas) genes as well as non-coding RNA elements capable of programming the specificity of the CRISPR-mediated nucleic acid cleavage.", "The individual Cas proteins do not share significant sequence similarity with protein components of the eukaryotic RNAi machinery, but have analogous predicted functions (e.g., RNA binding, nuclease, helicase, etc.)", "(Makarova et al., 2006.Biol.", "Direct 1: 7).", "The CRISPR-associated (cas) genes are often associated with CRISPR repeat-spacer arrays.", "More than forty different Cas protein families have been described.", "Of these protein families, Cas1 appears to be ubiquitous among different CRISPR/Cas systems.", "Particular combinations of cas genes and repeat structures have been used to define 8 CRISPR subtypes (Ecoli, Ypest, Nmeni, Dvulg, Tneap, Hmari, Apern, and Mtube), some of which are associated with an additional gene module encoding repeat-associated mysterious proteins (RAMPs).", "More than one CRISPR subtype may occur in a single genome.", "The sporadic distribution of the CRISPR/Cas subtypes suggests that the system is subject to horizontal gene transfer during microbial evolution.", "The Type II CRISPR, initially described in S. pyogenes, is one of the most well characterized systems and carries out targeted DNA double-strand break in four sequential steps.", "First, two non-coding RNA, the pre-crRNA array and tracrRNA, are transcribed from the CRISPR locus.", "Second, tracrRNA hybridizes to the repeat regions of the pre-crRNA and mediates the processing of pre-crRNA into mature crRNAs containing individual spacer sequences where processing occurs by a double strand-specific RNase III in the presence of the Cas9 protein.", "Third, the mature crRNA:tracrRNA complex directs Cas9 to the target DNA via Watson-Crick base-pairing between the spacer on the crRNA and the protospacer on the target DNA next to the protospacer adjacent motif (PAM), an additional requirement for target recognition.", "In addition, the tracrRNA must also be present as it base pairs with the crRNA at its 3′ end, and this association triggers Cas9 activity.", "Finally, Cas9 mediates cleavage of target DNA to create a double-stranded break within the protospacer.", "Activity of the CRISPR/Cas system comprises of three steps: (i) insertion of alien DNA sequences into the CRISPR array to prevent future attacks, in a process called ‘adaptation,’ (ii) expression of the relevant proteins, as well as expression and processing of the array, followed by (iii) RNA-mediated interference with the alien nucleic acid.", "Thus, in the bacterial cell, several of the so-called ‘Cas’ proteins are involved with the natural function of the CRISPR/Cas system.", "Type II CRISPR systems have been found in many different bacteria.", "BLAST searches on publically available genomes by Fonfara et al., ((2013) Nuc Acid Res 42(4):2377-2590) found Cas9 orthologs in 347 species of bacteria.", "Additionally, this group demonstrated in vitro CRISPR/Cas cleavage of a DNA target using Cas9 orthologs from S. pyogenes, S. mutans, S. therophilus, C. jejuni, N. meningitides, P. multocida and F. novicida.", "Thus, the term “Cas9” refers to an RNA guided DNA nuclease comprising a DNA binding domain and two nuclease domains, where the gene encoding the Cas9 may be derived from any suitable bacteria.", "The Cas9 protein has at least two nuclease domains: one nuclease domain is similar to a HNH endonuclease, while the other resembles a Ruv endonuclease domain.", "The HNH-type domain appears to be responsible for cleaving the DNA strand that is complementary to the crRNA while the Ruv domain cleaves the non-complementary strand.", "The Cas 9 nuclease can be engineered such that only one of the nuclease domains is functional, creating a Cas nickase (see Jinek, ibid).", "Nickases can be generated by specific mutation of amino acids in the catalytic domain of the enzyme, or by truncation of part or all of the domain such that it is no longer functional.", "Since Cas 9 comprises two nuclease domains, this approach may be taken on either domain.", "A double strand break can be achieved in the target DNA by the use of two such Cas 9 nickases.", "The nickases will each cleave one strand of the DNA and the use of two will create a double strand break.", "The primary products of the CRISPR loci appear to be short RNAs that contain the invader targeting sequences, and are termed guide RNAs or prokaryotic silencing RNAs (psiRNAs) based on their hypothesized role in the pathway (Makarova et al., 2006.Biol.", "Direct 1: 7; Hale et al., 2008.RNA, 14: 2572-2579).", "RNA analysis indicates that CRISPR locus transcripts are cleaved within the repeat sequences to release ˜60-to 70-nt RNA intermediates that contain individual invader targeting sequences and flanking repeat fragments (Tang et al., 2002.Proc.", "Natl.", "Acad.", "Sci.", "99: 7536-7541; Tang et al., 2005.Mol.", "Microbiol.", "55: 469-481; Lillestol et al., 2006.Archaea 2: 59-72; Brouns et al., 2008.Science 321: 960-964; Hale et al., 2008.RNA, 14: 2572-2579).", "In the archaeon Pyrococcus furiosus, these intermediate RNAs are further processed to abundant, stable ˜35-to 45-nt mature psiRNAs (Hale et al., 2008.RNA, 14: 2572-2579).", "The requirement of the crRNA-tracrRNA complex can be avoided by use of an engineered “single-guide RNA” (sgRNA) that comprises the hairpin normally formed by the annealing of the crRNA and the tracrRNA (see Jinek et al., (2012) Science 337:816 and Cong et al., (2013) Sciencexpress/10.1126/science.1231143).", "In S. pyrogenes, the engineered tracrRNA:crRNA fusion, or the sgRNA, guides Cas9 to cleave the target DNA when a double strand RNA:DNA heterodimer forms between the Cas associated RNAs and the target DNA.", "This system comprising the Cas9 protein and an engineered sgRNA containing a PAM sequence has been used for RNA guided genome editing (see Ramalingam, ibid) and has been useful for zebrafish embryo genomic editing in vivo (see Hwang et al., (2013) Nature Biotechnology 31 (3):227) with editing efficiencies similar to ZFNs and TALENs.", "Other Cas Proteins “Cas1” polypeptide refers to CRISPRassociated (Cas) protein1.Cas1 (COG1518 in the Clusters of Orthologous Group of proteins classification system) is the best marker of the CRISPR-associated systems (CASS).", "Based on phylogenetic comparisons, seven distinct versions of the CRISPR-associated immune system have been identified (CASS1-7).", "Cas1 polypeptide used in the methods described herein can be any Cas1 polypeptide present in any prokaryote.", "In certain embodiments, a Cas1 polypeptide is a Cas1 polypeptide of an archaeal microorganism.", "In certain embodiments, a Cas1 polypeptide is a Cas1 polypeptide of a Euryarchaeota microorganism.", "In certain embodiments, a Cas1 polypeptide is a Cas1 polypeptide of a Crenarchaeota microorganism.", "In certain embodiments, a Cas1 polypeptide is a Cas1 polypeptide of a bacterium.", "In certain embodiments, a Cas1 polypeptide is a Cas1 polypeptide of a gram negative or gram positive bacteria.", "In certain embodiments, a Cas1 polypeptide is a Cas1 polypeptide of Pseudomonas aeruginosa.", "In certain embodiments, a Cas1 polypeptide is a Cas1 polypeptide of Aquifex aeolicus.", "In certain embodiments, a Cas1 polypeptide is a Cas1 polypeptide that is a member of one of CASS1-7.In certain embodiments, Cas1 polypeptide is a Cas1 polypeptide that is a member of CASS3.In certain embodiments, a Cas1 polypeptide is a Cas1 polypeptide that is a member of CASS7.In certain embodiments, a Cas1 polypeptide is a Cas1 polypeptide that is a member of CASS3 or CASS7.In some embodiments, a Cas1 polypeptide is encoded by a nucleotide sequence provided in GenBank at, e.g., GeneID number: 2781520, 1006874, 9001811, 947228, 3169280, 2650014, 1175302, 3993120, 4380485, 906625, 3165126, 905808, 1454460, 1445886, 1485099, 4274010, 888506, 3169526, 997745, 897836, or 1193018 and/or an amino acid sequence exhibiting homology (e.g., greater than 80%, 90 to 99% including 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99%) to the amino acids encoded by these polynucleotides and which polypeptides function as Cas1 polypeptides.", "Cas6 is another Cas polypeptide, and the endoribonuclease activity is referred to herein as Cas6 endoribonuclease activity.", "Non-limiting examples of suitable Cas6 polypeptides are depicted at Genbank Accession No.", "AAL81255.A Cas6 polypeptide may be enriched, isolated, or purified from a microbe having a CRISPR locus and the cas (CRISPR-associated) locus, such as, but not limited to, Pyrococcus furiosus, or may be produced using recombinant techniques, or chemically or enzymatically synthesized using routine methods.", "In some aspects, a Cas6 polypeptide may be enriched, isolated, or purified from a microbe that does not have CRISPR loci.", "A Cas6 polypeptide may include a GhGxxxxxGhG (SEQ ID NO:216) motif (where “h” indicates a hydrophobic amino acid) near the C-terminus.", "An Arg or Lys may be, and often is, found within the central stretch of 5 amino acids.", "A Cas6 polypeptide contains at least one residue that may play a role in catalysis, or conservative substitution thereof.", "A Cas6 polypeptide may contain other residues which may also play a role in catalysis, or conservative substitution thereof.", "The residue(s) expected to play a role in catalysis may be located near the G-rich loop that contains the Cas6 signature motif in the 3D structure of the protein.", "Cas6 polypeptides may include domains present in the TIGRFAM database at accession numbers TIGR01877 and PF01881.The TIGRFAM database includes families of polypeptides for which function is conserved (Haft et al., Nucl.", "Acids Res., 2003, 31:371-373, Bateman and Haft, 2002, Briefings Bioinformatics, 3:236-245, and Haft et al., 2005, PLoS Computational Biol., 1(6):e60).", "Other examples of Cas6 polypeptides provided herein include those present in prokaryotic microbes having a CRISPR locus and a cas locus.", "Cas6 polypeptides can be easily identified in any microbe that includes a CRISPR locus.", "A coding region encoding a Cas6 polypeptide is typically in a cas locus located in close proximity to a CRISPR locus.", "Haft et al., (2005, PLoS Computational Biol., 1(6):e60) review the Cas protein family, and created rules for the identification of specific subtypes of the CRISPR/Cas system.", "Haft et al., describe the coding region encoding Cas6 polypeptides as being found in association with at least four separate CRISPR/Cas subtypes (Tneap, Hmari, Apern, and Mtube), and as typically being the cas coding region located most distal to the CRISPR locus.", "Cas6 polypeptides may be identified using the resources available at the JCVI Comprehensive Microbial Resource.", "Thus, Cas6 polypeptides that are useful in the methods described herein can be identified by the skilled person using routine methods.", "Examples of prokaryotic microbes with known whole genomic sequences containing coding regions expected to encode a Cas6 polypeptide include Thermotoga maritima MSB8, Campylobacter fetus subsp.", "fetus 82-40, Fusobacterium nucleatum ATCC 25586, Streptococcus thermophilus LMG 18311, Thermoanaerobacter tengcongensis MB4(T), Moorella thermoacetica ATCC 39073, Desulfitobacterium hafniense Y51, Clostridium tetani E88, Clostridium perfringens SM101, Clostridium difficile QCD-32g58, Clostridium botulinum Hall A Sanger, Clostridium botulinum F Langeland, Clostridium botulinum B1 strain Okra, Clostridium botulinum A3 strain Loch Maree, Clostridium botulinum A Hall, Clostridium botulinum A ATCC 19397, Carboxydothermus hydrogenoformans Z-2901, Staphylococcus epidermidis RP62A, Thermus thermophilus HB8, Thermus thermophilus HB27, Nostoc sp.", "PCC 7120, Anabaena variabilis ATCC 29413, Synechococccus sp.", "OS Type B prime, Synechococccus sp.", "OS Type A, Porphyromonas gingivalis W83, Bacteroides fragilis YCH46, Bacteroides fragilis NCTC9343, Aquifex aeolicus VF5, Rubrobacter xylanophilus DSM 9941, Mycobacterium tuberculosis H37Rv (lab strain), Mycobacterium tuberculosis CDC1551, Mycobacterium bovis subsp.", "bovis AF2122/97, Frankia alni ACN14a, Thermoplasma volcanium GSS1, Picrophilus torridus DSM 9790, Thermococcus kodakarensis KOD1, Pyrococcus horikoshii shinkaj OT3, Pyrococcus furiosus DSM 3638, Pyrococcus abyssi GE5, Methanosarcina barkeri fusaro, Methanosarcina acetivorans C2A, Methanococcoides burtonii DSM 6242, Methanococcus jannaschii DSM2661, Methanobacterium thermoautotrophicum delta H, Haloarcula marismortui ATCC 43049, Archaeoglobus fulgidus DSM4304, Pyrobaculum aerophilum 1M2, Sulfolobus tokodaii strain 7, Sulfolobus solfataricus P2, Sulfolobus acidocaldarius DSM 639, Aeropyrum pernix K1.Other examples of Cas6 polypeptides are known to the skilled person, see, for instance, members of the COG1583 group of polypeptides (available at the Clusters of Orthologous Groups of proteins (COGs) web page through the National Center for Biotechnology Information internet site, see also Tatusov et al., (1997), Science, 278:631-637, and Tatusov et al., (2003), BMC Bioinformatics, 4(1):41), members of the InterPro family having accession number IPRO10156, Makarova et al., (2002), Nuc.", "Acids Res., 30:482-496 and Haft et al., (2005), PLoS Comput.", "Biol., 1(6):e60, 474-483).", "In certain embodiments, Cas protein may be a “functional derivative” of a naturally occurring Cas protein.", "A “functional derivative” of a native sequence polypeptide is a compound having a qualitative biological property in common with a native sequence polypeptide.", "“Functional derivatives” include, but are not limited to, fragments of a native sequence and derivatives of a native sequence polypeptide and its fragments, provided that they have a biological activity in common with a corresponding native sequence polypeptide.", "A biological activity contemplated herein is the ability of the functional derivative to hydrolyze a DNA substrate into fragments.", "The term “derivative” encompasses both amino acid sequence variants of polypeptide, covalent modifications, and fusions thereof.", "In some aspects, a functional derivative may comprise a single biological property of a naturally occurring Cas protein.", "In other aspects, a function derivative may comprise a subset of biological properties of a naturally occurring Cas protein.", "“Cas1 polypeptide” encompasses a full-length Cas polypeptide, an enzymatically active fragment of a Cas polypeptide, and enzymatically active derivatives of a Cas polypeptide or fragment thereof.", "Suitable derivatives of a Cas polypeptide or a fragment thereof include but are not limited to mutants, fusions, covalent modifications of Cas protein or a fragment thereof.", "Cas protein which includes Cas protein or a fragment thereof, as well as derivatives of Cas protein or a fragment thereof, may be obtainable from a cell or synthesized chemically or by a combination of these two procedures.", "The cell may be a cell that naturally produces Cas protein, or a cell that naturally produces Cas protein and is genetically engineered to produce the endogenous Cas protein at a higher expression level or to produce a Cas protein from an exogenously introduced nucleic acid, which nucleic acid encodes a Cas that is same or different from the endogenous Cas.", "In some case, the cell does not naturally produce Cas protein and is genetically engineered to produce a Cas protein.", "The CRISPR/Cas system can also be used to inhibit gene expression.", "Lei et al., (see, (2013) Cell, 152, (5): 1173-1183) have shown that a catalytically dead Cas9 lacking endonuclease activity, when coexpressed with a guide RNA, generates a DNA recognition complex that can specifically interfere with transcriptional elongation, RNA polymerase binding, or transcription factor binding.", "This system, called CRISPR interference (CRISPRi), can efficiently repress expression of targeted genes.", "The Cas proteins of the invention may be mutated to alter functionality.", "Exemplary selection methods, including phage display and two-hybrid systems, are disclosed in U.S. Pat.", "Nos.", "5,789,538; 5,925,523; 6,007,988; 6,013,453; 6,410,248; 6,140,466; 6,200,759; and 6,242,568; as well as International Patent Publication Nos.", "WO 98/37186; WO 98/53057; WO 00/27878; and WO 01/88197 and GB 2,338,237.In addition, enhancement of binding specificity for zinc finger binding domains has been described, for example, in co-owned WO 02/077227.Selection of target sites; DNA-binding domains and methods for design and construction of fusion proteins (and polynucleotides encoding same) are known to those of skill in the art and described in detail in U.S. Pat.", "Nos.", "8,586,526; 6,140,081; 5,789,538; 6,453,242; 6,534,261; 5,925,523; 6,007,988; 6,013,453; and 6,200,759; and International Patent Publication Nos.", "WO 95/19431; WO 96/06166; WO 98/53057; WO 98/54311; WO 00/27878; WO 01/60970; WO 01/88197; WO 02/099084; WO 98/53058; WO 98/53059; WO 98/53060; WO 02/016536; and WO 03/016496.Functional Domains The systems described herein can include any suitable functional domain that associates with the single guide RNA to act on the target gene.", "Non-limiting examples of functional domains include transcriptional activation domains, transcriptional repression domains and/or nuclease domains.", "See, e.g., U.S. Pat.", "Nos.", "6,534,261 and 8,409,861.In certain embodiments, the functional domain comprises one or more cleavage domains.", "The functional domain (e.g., cleavage domain) may be heterologous to the DNA-binding domain, for example a functional domain that is heterologous to the single-guide RNA of the CRISPR/Cas system.", "Heterologous cleavage domains can be obtained from any endonuclease or exonuclease.", "Exemplary endonucleases from which a cleavage domain can be derived include, but are not limited to, restriction endonucleases and homing endonucleases.", "See, for example, 2002-2003 Catalogue, New England Biolabs, Beverly, Mass.", "; and Belfort et al., (1997) Nucleic Acids Res.", "25:3379-3388.Additional enzymes which cleave DNA are known (e.g., S1 Nuclease; mung bean nuclease; pancreatic DNase I; micrococcal nuclease; yeast HO endonuclease; see also Linn et al., (eds.)", "Nucleases, Cold Spring Harbor Laboratory Press, 1993).", "One or more of these enzymes (or functional fragments thereof) can be used as a source of cleavage domains and cleavage half-domains.", "In some embodiments, a Cas protein may be linked to a heterologous nuclease domain.", "In some aspects, the Cas protein is a Cas9 protein devoid of nuclease activity linked to a FokI nuclease domain such that double strand cleavage is dependent on dimerization of the FokI nuclease domains.", "Similarly, a cleavage half-domain can be derived from any nuclease or portion thereof, as set forth above, that requires dimerization for cleavage activity.", "In general, two fusion proteins are required for cleavage if the fusion proteins comprise cleavage half-domains.", "Alternatively, a single protein comprising two cleavage half-domains can be used.", "The two cleavage half-domains can be derived from the same endonuclease (or functional fragments thereof), or each cleavage half-domain can be derived from a different endonuclease (or functional fragments thereof).", "In addition, the target sites for the two fusion proteins are preferably disposed, with respect to each other, such that binding of the two fusion proteins to their respective target sites places the cleavage half-domains in a spatial orientation to each other that allows the cleavage half-domains to form a functional cleavage domain, e.g., by dimerizing.", "Thus, in certain embodiments, the near edges of the target sites are separated by 5-8 nucleotides or by 15-18 nucleotides.", "However any integral number of nucleotides or nucleotide pairs can intervene between two target sites (e.g., from 2 to 50 nucleotide pairs or more).", "In general, the site of cleavage lies between the target sites.", "Restriction endonucleases (restriction enzymes) are present in many species and are capable of sequence-specific binding to DNA (at a recognition site), and cleaving DNA at or near the site of binding.", "Certain restriction enzymes (e.g., Type IIS) cleave DNA at sites removed from the recognition site and have separable binding and cleavage domains.", "For example, the Type IIS enzyme Fok I catalyzes double-stranded cleavage of DNA, at 9 nucleotides from its recognition site on one strand and 13 nucleotides from its recognition site on the other.", "See, for example, U.S. Pat.", "Nos.", "5,356,802; 5,436,150; and 5,487,994; as well as Li et al., (1992) Proc.", "Natl.", "Acad.", "Sci.", "USA 89:4275-4279; Li et al., (1993) Proc.", "Natl.", "Acad.", "Sci.", "USA 90:2764-2768; Kim et al., (1994a) Proc.", "Natl.", "Acad.", "Sci.", "USA 91:883-887; Kim et al., (1994b) J. Biol.", "Chem.", "269:31,978-31,982.Thus, in one embodiment, fusion proteins comprise the cleavage domain (or cleavage half-domain) from at least one Type IIS restriction enzyme and one or more zinc finger binding domains, which may or may not be engineered.", "An exemplary Type IIS restriction enzyme, whose cleavage domain is separable from the binding domain, is Fok I.", "This particular enzyme is active as a dimer.", "Bitinaite et al., (1998) Proc.", "Natl.", "Acad.", "Sci.", "USA 95: 10,570-10,575.Accordingly, for the purposes of the present disclosure, the portion of the Fok I enzyme used in the disclosed fusion proteins is considered a cleavage half-domain.", "Thus, for targeted double-stranded cleavage and/or targeted replacement of cellular sequences using zinc finger-Fok I fusions, two fusion proteins, each comprising a FokI cleavage half-domain, can be used to reconstitute a catalytically active cleavage domain.", "Alternatively, a single polypeptide molecule containing a DNA binding domain and two Fok I cleavage half-domains can also be used.", "A cleavage domain or cleavage half-domain can be any portion of a protein that retains cleavage activity, or that retains the ability to multimerize (e.g., dimerize) to form a functional cleavage domain.", "Exemplary Type IIS restriction enzymes are described in International Patent Publication No.", "WO 07/014275, incorporated herein in its entirety.", "Additional restriction enzymes also contain separable binding and cleavage domains, and these are contemplated by the present disclosure.", "See, for example, Roberts et al., (2003) Nucleic Acids Res.", "31:418-420.In certain embodiments, the cleavage domain comprises one or more engineered cleavage half-domain (also referred to as dimerization domain mutants) that minimize or prevent homodimerization, as described, for example, in U.S. Pat.", "Nos.", "7,914,796; 8,034,598; and 8,623,618, the disclosures of all of which are incorporated by reference in their entireties herein.", "Amino acid residues at positions 446, 447, 479, 483, 484, 486, 487, 490, 491, 496, 498, 499, 500, 531, 534, 537, and 538 of Fok I are all targets for influencing dimerization of the Fok I cleavage half-domains.", "Exemplary engineered cleavage half-domains of Fok I that form obligate heterodimers include a pair in which a first cleavage half-domain includes mutations at amino acid residues at positions 490 and 538 of Fok I and a second cleavage half-domain includes mutations at amino acid residues 486 and 499.Thus, in one embodiment, a mutation at 490 replaces Glu (E) with Lys (K); the mutation at 538 replaces Iso (I) with Lys (K); the mutation at 486 replaced Gln (Q) with Glu (E); and the mutation at position 499 replaces Iso (I) with Lys (K).", "Specifically, the engineered cleavage half-domains described herein were prepared by mutating positions 490 (E→K) and 538 (I→K) in one cleavage half-domain to produce an engineered cleavage half-domain designated “E490K:I538K” and by mutating positions 486 (Q→E) and 499 (I→L) in another cleavage half-domain to produce an engineered cleavage half-domain designated “Q486E:I499L”.", "The engineered cleavage half-domains described herein are obligate heterodimer mutants in which aberrant cleavage is minimized or abolished.", "In certain embodiments, the engineered cleavage half-domain comprises mutations at positions 486, 499 and 496 (numbered relative to wild-type FokI), for instance mutations that replace the wild type Gln (Q) residue at position 486 with a Glu (E) residue, the wild type Iso (I) residue at position 499 with a Leu (L) residue and the wild-type Asn (N) residue at position 496 with an Asp (D) or Glu (E) residue (also referred to as a “ELD” and “ELE” domains, respectively).", "In other embodiments, the engineered cleavage half-domain comprises mutations at positions 490, 538 and 537 (numbered relative to wild-type FokI), for instance mutations that replace the wild type Glu (E) residue at position 490 with a Lys (K) residue, the wild type Iso (I) residue at position 538 with a Lys (K) residue, and the wild-type His (H) residue at position 537 with a Lys (K) residue or a Arg (R) residue (also referred to as “KKK” and “KKR” domains, respectively).", "In other embodiments, the engineered cleavage half-domain comprises mutations at positions 490 and 537 (numbered relative to wild-type FokI), for instance mutations that replace the wild type Glu (E) residue at position 490 with a Lys (K) residue and the wild-type His (H) residue at position 537 with a Lys (K) residue or a Arg (R) residue (also referred to as “KIK” and “KIR” domains, respectively).", "(See U.S. Patent Publication No.", "2011/0201055, incorporated by reference herein).", "Engineered cleavage half-domains described herein can be prepared using any suitable method, for example, by site-directed mutagenesis of wild-type cleavage half-domains (Fok I).", "Alternatively, nucleases may be assembled in vivo at the nucleic acid target site using so-called “split-enzyme” technology (see, e.g., U.S. Patent Publication No.", "2009/0068164).", "Components of such split enzymes may be expressed either on separate expression constructs, or can be linked in one open reading frame where the individual components are separated, for example, by a self-cleaving 2A peptide or IRES sequence.", "Components may be individual zinc finger binding domains or domains of a meganuclease nucleic acid binding domain.", "Nucleases can be screened for activity prior to use, for example in a yeast-based chromosomal system as described in U.S. Pat.", "No.", "8,563,314.Nuclease expression constructs can be readily designed using methods known in the art.", "Expression of the nuclease may be under the control of a constitutive promoter or an inducible promoter, for example the galactokinase promoter which is activated (de-repressed) in the presence of raffinose and/or galactose and repressed in presence of glucose.", "RNA Components of CRISPR/Cas The Cas9 related CRISPR/Cas system comprises two RNA non-coding components: tracrRNA and a pre-crRNA array containing nuclease guide sequences (spacers) interspaced by identical direct repeats (DRs).", "To use a CRISPR/Cas system to accomplish genome engineering, both functions of these RNAs must be present (see Cong et al., (2013) Sciencexpress 1/10.1126/science 1231143).", "In some embodiments, the tracrRNA and pre-crRNAs are supplied via separate expression constructs or as separate RNAs.", "In other embodiments, a chimeric RNA is constructed where an engineered mature crRNA (conferring target specificity) is fused to a tracrRNA (supplying interaction with the Cas9) to create a chimeric cr-RNA-tracrRNA hybrid (also termed a single guide RNA).", "(see Jinek, ibid and Cong, ibid).", "Chimeric or sgRNAs can be engineered to comprise a sequence complementary to any desired target.", "The RNAs comprise 22 bases of complementarity to a target and of the form G[n19], followed by a protospacer-adjacent motif (PAM) of the form NGG.", "Thus, in one method, sgRNAs can be designed by utilization of a known ZFN target in a gene of interest by (i) aligning the recognition sequence of the ZFN heterodimer with the reference sequence of the relevant genome (human, mouse, or of a particular plant species); (ii) identifying the spacer region between the ZFN half-sites; (iii) identifying the location of the motif G[N20]GG that is closest to the spacer region (when more than one such motif overlaps the spacer, the motif that is centered relative to the spacer is chosen); (iv) using that motif as the core of the sgRNA.", "This method advantageously relies on proven nuclease targets.", "Alternatively, sgRNAs can be designed to target any region of interest simply by identifying a suitable target sequence the conforms to the G[n20]GG formula.", "Along with the complementarity region, an sgRNA may comprise additional nucleotides to extend to tail region of the tracrRNA portion of the sgRNA (see Hsu et al., (2013) Nature Biotech doi:10.1038/nbt.2647).", "Tails may be of +67 to +85 nucleotides, or any number therebetween with a preferred length of +85 nucleotides.", "Truncated sgRNAs may also be used, “tru-gRNAs” (see Fu et al., (2014) Nature Biotech 32(3): 279).", "In tru-gRNAs, the complementarity region is diminished to 17 or 18 nucleotides in length.", "Further, alternative PAM sequences may also be utilized, where a PAM sequence can be NAG as an alternative to NGG (Hsu, ibid) using a S. pyogenes Cas9.Additional PAM sequences may also include those lacking the initial G (Sander and Joung (2014) Nature Biotech 32(4):347).", "In addition to the S. pyogenes encoded Cas9 PAM sequences, other PAM sequences can be used that are specific for Cas9 proteins from other bacterial sources.", "For example, the PAM sequences shown below (adapted from Sander and Joung, ibid, and Esvelt et al., (2013) Nat Meth 10(11):1116) are specific for these Cas9 proteins: Species PAM S. pyogenes NGG S. pyogenes NAG S. mutans NGG S. thermophilius NGGNG S. thermophilius NNAAAW S. thermophilius NNAGAA S. thermophilius NNNGATT C. jejuni NNNNACA N. meningitides NNNNGATT P. multocida GNNNCNNA F. novicida NG Thus, a suitable target sequence for use with a S. pyogenes CRISPR/Cas system can be chosen according to the following guideline: [n17, n18, n19, or n20](G/A)G. Alternatively the PAM sequence can follow the guideline G[n17, n18, n19, n20](G/A)G. For Cas9 proteins derived from non-S. pyogenes bacteria, the same guidelines may be used where the alternate PAMs are substituted in for the S. pyogenes PAM sequences.", "Most preferred is to choose a target sequence with the highest likelihood of specificity that avoids potential off target sequences.", "These undesired off target sequences can be identified by considering the following attributes: i) similarity in the target sequence that is followed by a PAM sequence known to function with the Cas9 protein being utilized; ii) a similar target sequence with fewer than three mismatches from the desired target sequence; iii) a similar target sequence as in ii), where the mismatches are all located in the PAM distal region rather than the PAM proximal region (there is some evidence that nucleotides 1-5 immediately adjacent or proximal to the PAM, sometimes referred to as the ‘seed’ region (Wu et al., (2014) Nature Biotech doi:10.1038/nbt2889) are the most critical for recognition, so putative off target sites with mismatches located in the seed region may be the least likely be recognized by the sg RNA); and iv) a similar target sequence where the mismatches are not consecutively spaced or are spaced greater than four nucleotides apart (Hsu, ibid).", "Thus, by performing an analysis of the number of potential off target sites in a genome for whichever CRIPSR/Cas system is being employed, using these criteria above, a suitable target sequence for the sgRNA may be identified.", "Donors As noted above, insertion of an exogenous sequence (also called a “donor sequence” or “donor” or “transgene”), for example for correction of a mutant gene or for increased expression of a wild-type gene.", "It will be readily apparent that the donor sequence is typically not identical to the genomic sequence where it is placed.", "A donor sequence can contain a non-homologous sequence flanked by two regions of homology to allow for efficient HDR at the location of interest.", "Alternatively, a donor may have no regions of homology to the targeted location in the DNA and may be integrated by NHEJ-dependent end joining following cleavage at the target site.", "Additionally, donor sequences can comprise a vector molecule containing sequences that are not homologous to the region of interest in cellular chromatin.", "A donor molecule can contain several, discontinuous regions of homology to cellular chromatin.", "For example, for targeted insertion of sequences not normally present in a region of interest, said sequences can be present in a donor nucleic acid molecule and flanked by regions of homology to sequence in the region of interest.", "The donor polynucleotide can be DNA or RNA, single-stranded and/or double-stranded and can be introduced into a cell in linear or circular form.", "See, e.g., U.S. Patent Publication Nos.", "2010/0047805 and 2011/0207221.If introduced in linear form, the ends of the donor sequence can be protected (e.g., from exonucleolytic degradation) by methods known to those of skill in the art.", "For example, one or more dideoxynucleotide residues are added to the 3′ terminus of a linear molecule and/or self-complementary oligonucleotides are ligated to one or both ends.", "See, for example, Chang et al., (1987) Proc.", "Natl.", "Acad.", "Sci.", "USA 84:4959-4963; Nehls et al., (1996) Science 272:886-889.Additional methods for protecting exogenous polynucleotides from degradation include, but are not limited to, addition of terminal amino group(s) and the use of modified internucleotide linkages such as, for example, phosphorothioates, phosphoramidates, and O-methyl ribose or deoxyribose residues.", "A polynucleotide can be introduced into a cell as part of a vector molecule having additional sequences such as, for example, replication origins, promoters and genes encoding antibiotic resistance.", "Moreover, donor polynucleotides can be introduced as naked nucleic acid, as nucleic acid complexed with an agent such as a liposome or poloxamer, or can be delivered by viruses (e.g., adenovirus, AAV, herpesvirus, retrovirus, lentivirus and integrase defective lentivirus (IDLV)).", "The donor is generally inserted so that its expression is driven by the endogenous promoter at the integration site, namely the promoter that drives expression of the endogenous gene into which the donor is inserted (e.g., globin, AAVS1, etc.).", "However, it will be apparent that the donor may comprise a promoter and/or enhancer, for example a constitutive promoter or an inducible or tissue specific promoter.", "The donor molecule may be inserted into an endogenous gene such that all, some or none of the endogenous gene is expressed.", "In other embodiments, the transgene (e.g., with or without globin encoding sequences) is integrated into any endogenous locus, for example a safe-harbor locus.", "See, e.g., U.S. Patent Publication Nos.", "2008/0299580; 2008/0159996; and 2010/0218264.Furthermore, although not required for expression, exogenous sequences may also include transcriptional or translational regulatory sequences, for example, promoters, enhancers, insulators, internal ribosome entry sites, sequences encoding 2A peptides and/or polyadenylation signals.", "Delivery The nucleases, polynucleotides encoding these nucleases, donor polynucleotides and compositions comprising the proteins and/or polynucleotides described herein may be delivered in vivo or ex vivo by any suitable means.", "Methods of delivering nucleases as described herein are described, for example, in U.S. Pat.", "Nos.", "6,453,242; 6,503,717; 6,534,261; 6,599,692; 6,607,882; 6,689,558; 6,824,978; 6,933,113; 6,979,539; 7,013,219; and 7,163,824, the disclosures of all of which are incorporated by reference herein in their entireties.", "Nucleases and/or donor constructs as described herein may also be delivered using vectors containing sequences encoding one or more of the CRISPR/Cas system(s).", "Any vector systems may be used including, but not limited to, plasmid vectors, DNA minicircles, retroviral vectors, lentiviral vectors, adenovirus vectors, poxvirus vectors; herpesvirus vectors and adeno-associated virus vectors, etc., and combinations thereof.", "See, also, U.S. Pat.", "Nos.", "6,534,261; 6,607,882; 6,824,978; 6,933,113; 6,979,539; 7,013,219; and 7,163,824, and U.S. Patent Publication No.", "2014/0335063, incorporated by reference herein in their entireties.", "Furthermore, it will be apparent that any of these vectors may comprise one or more of the sequences needed for treatment.", "Thus, when one or more nucleases and a donor construct are introduced into the cell, the nucleases and/or donor polynucleotide may be carried on the same vector or on different vectors.", "When multiple vectors are used, each vector may comprise a sequence encoding one or multiple nucleases and/or donor constructs.", "Conventional viral and non-viral based gene transfer methods can be used to introduce nucleic acids encoding nucleases and donor constructs in cells (e.g., mammalian cells) and target tissues.", "Non-viral vector delivery systems include DNA plasmids, DNA minicircles, naked nucleic acid, and nucleic acid complexed with a delivery vehicle such as a liposome or poloxamer.", "Viral vector delivery systems include DNA and RNA viruses, which have either episomal or integrated genomes after delivery to the cell.", "For a review of gene therapy procedures, see Anderson, Science 256:808-813 (1992); Nabel & Felgner, TIBTECH 11:211-217 (1993); Mitani & Caskey, TIBTECH 11:162-166 (1993); Dillon, TIBTECH 11:167-175 (1993); Miller, Nature 357:455-460 (1992); Van Brunt, Biotechnology 6(10):1149-1154 (1988); Vigne, Restorative Neurology and Neuroscience 8:35-36 (1995); Kremer & Perricaudet, British Medical Bulletin 51(1):31-44 (1995); Haddada et al., in Current Topics in Microbiology and Immunology Doerfler and Bohm (eds.)", "(1995); and Yu et al., Gene Therapy 1:13-26 (1994).", "Methods of non-viral delivery of nucleic acids include electroporation, lipofection, microinjection, biolistics, virosomes, liposomes, immunoliposomes, polycation or lipid:nucleic acid conjugates, naked DNA, naked RNA, capped RNA, artificial virions, and agent-enhanced uptake of DNA.", "Sonoporation using, e.g., the Sonitron 2000 system (Rich-Mar) can also be used for delivery of nucleic acids.", "Additional exemplary nucleic acid delivery systems include those provided by Amaxa Biosystems (Cologne, Germany), Maxcyte, Inc. (Rockville, Md.", "), BTX Molecular Delivery Systems (Holliston, Mass.)", "and Copernicus Therapeutics Inc, (see for example U.S. Pat.", "No.", "6,008,336).", "Lipofection is described in e.g., U.S. Pat.", "Nos.", "5,049,386; 4,946,787; and 4,897,355) and lipofection reagents are sold commercially (e.g., Transfectam™ and Lipofectin™).", "Cationic and neutral lipids that are suitable for efficient receptor-recognition lipofection of polynucleotides include those of Felgner, WO 91/17424, WO 91/16024.The preparation of lipid:nucleic acid complexes, including targeted liposomes such as immunolipid complexes, is well known to one of skill in the art (see, e.g., Crystal, Science 270:404-410 (1995); Blaese et al., Cancer Gene Ther.", "2:291-297 (1995); Behr et al., Bioconjugate Chem.", "5:382-389 (1994); Remy et al., Bioconjugate Chem.", "5:647-654 (1994); Gao et al., Gene Therapy 2:710-722 (1995); Ahmad et al., Cancer Res.", "52:4817-4820 (1992); U.S. Pat.", "Nos.", "4,186,183; 4,217,344; 4,235,871; 4,261,975; 4,485,054; 4,501,728; 4,774,085; 4,837,028; and 4,946,787).", "Additional methods of delivery include the use of packaging the nucleic acids to be delivered into EnGeneIC delivery vehicles (EDVs).", "These EDVs are specifically delivered to target tissues using bispecific antibodies where one arm of the antibody has specificity for the target tissue and the other has specificity for the EDV.", "The antibody brings the EDVs to the target cell surface and then the EDV is brought into the cell by endocytosis.", "Once in the cell, the contents are released (see MacDiarmid et al., (2009) Nature Biotechnology 27(7):643).", "The use of RNA or DNA viral based systems for the delivery of nucleic acids encoding engineered CRISPR/Cas systems take advantage of highly evolved processes for targeting a virus to specific cells in the body and trafficking the viral payload to the nucleus.", "Viral vectors can be administered directly to subjects (in vivo) or they can be used to treat cells in vitro and the modified cells are administered to subjects (ex vivo).", "Conventional viral based systems for the delivery of CRISPR/Cas systems include, but are not limited to, retroviral, lentivirus, adenoviral, adeno-associated, vaccinia and herpes simplex virus vectors for gene transfer.", "Integration in the host genome is possible with the retrovirus, lentivirus, and adeno-associated virus gene transfer methods, often resulting in long term expression of the inserted transgene.", "Additionally, high transduction efficiencies have been observed in many different cell types and target tissues.", "The tropism of a retrovirus can be altered by incorporating foreign envelope proteins, expanding the potential target population of target cells.", "Lentiviral vectors are retroviral vectors that are able to transduce or infect non-dividing cells and typically produce high viral titers.", "Selection of a retroviral gene transfer system depends on the target tissue.", "Retroviral vectors are comprised of cis-acting long terminal repeats with packaging capacity for up to 6-10 kb of foreign sequence.", "The minimum cis-acting LTRs are sufficient for replication and packaging of the vectors, which are then used to integrate the therapeutic gene into the target cell to provide permanent transgene expression.", "Widely used retroviral vectors include those based upon murine leukemia virus (MuLV), gibbon ape leukemia virus (GaLV), Simian Immunodeficiency virus (SIV), human immunodeficiency virus (HIV), and combinations thereof (see, e.g., Buchscher et al., J. Virol.", "66:2731-2739 (1992); Johann et al., J. Virol.", "66:1635-1640 (1992); Sommerfelt et al., Virol.", "176:58-59 (1990); Wilson et al., J. Virol.", "63:2374-2378 (1989); Miller et al., J. Virol.", "65:2220-2224 (1991); PCT/US94/05700).", "In applications in which transient expression is preferred, adenoviral based systems can be used.", "Adenoviral based vectors are capable of very high transduction efficiency in many cell types and do not require cell division.", "With such vectors, high titer and high levels of expression have been obtained.", "This vector can be produced in large quantities in a relatively simple system.", "Adeno-associated virus (“AAV”) vectors are also used to transduce cells with target nucleic acids, e.g., in the in vitro production of nucleic acids and peptides, and for in vivo and ex vivo gene therapy procedures (see, e.g., West et al., Virology 160:38-47 (1987); U.S. Pat.", "No.", "4,797,368; International Patent Publication No.", "WO 93/24641; Kotin, Human Gene Therapy 5:793-801 (1994); Muzyczka, J. Clin.", "Invest.", "94:1351 (1994).", "Construction of recombinant AAV vectors are described in a number of publications, including U.S. Pat.", "No.", "5,173,414; Tratschin et al., Mol.", "Cell.", "Biol.", "5:3251-3260 (1985); Tratschin, et al., Mol.", "Cell.", "Biol.", "4:2072-2081 (1984); Hermonat & Muzyczka, PNAS 81:6466-6470 (1984); and Samulski et al., J. Virol.", "63:03822-3828 (1989).", "At least six viral vector approaches are currently available for gene transfer in clinical trials, which utilize approaches that involve complementation of defective vectors by genes inserted into helper cell lines to generate the transducing agent.", "pLASN and MFG-S are examples of retroviral vectors that have been used in clinical trials (Dunbar et al., Blood 85:3048-305 (1995); Kohn et al., Nat.", "Med.", "1:1017-102 (1995); Malech et al., PNAS 94:22 12133-12138 (1997)).", "PA317/pLASN was the first therapeutic vector used in a gene therapy trial.", "(Blaese et al., Science 270:475-480 (1995)).", "Transduction efficiencies of 50% or greater have been observed for MFG-S packaged vectors.", "(Ellem et al., Immunol Immunother 44(1):10-20 (1997); Dranoff et al., Hum.", "Gene Ther.", "1:111-2 (1997).", "Recombinant adeno-associated virus vectors (rAAV) are a promising alternative gene delivery systems based on the defective and nonpathogenic parvovirus adeno-associated type 2 virus.", "All vectors are derived from a plasmid that retains only the AAV 145 base pair (bp) inverted terminal repeats flanking the transgene expression cassette.", "Efficient gene transfer and stable transgene delivery due to integration into the genomes of the transduced cell are key features for this vector system.", "(Wagner et al., Lancet 351:9117 1702-3 (1998), Kearns et al., Gene Ther.", "9:748-55 (1996)).", "Other AAV serotypes, including AAV1, AAV3, AAV4, AAV5, AAV6, AAV8, AAV9 and AAVrh10, and all variants thereof, can also be used in accordance with the present invention.", "Replication-deficient recombinant adenoviral vectors (Ad) can be produced at high titer and readily infect a number of different cell types.", "Most adenovirus vectors are engineered such that a transgene replaces the Ad E1a, E1b, and/or E3 genes; subsequently the replication defective vector is propagated in human 293 cells that supply deleted gene function in trans.", "Ad vectors can transduce multiple types of tissues in vivo, including non-dividing, differentiated cells such as those found in liver, kidney and muscle.", "Conventional Ad vectors have a large carrying capacity.", "An example of the use of an Ad vector in a clinical trial involved polynucleotide therapy for anti-tumor immunization with intramuscular injection (Sterman et al., Hum.", "Gene Ther.", "7:1083-9 (1998)).", "Additional examples of the use of adenovirus vectors for gene transfer in clinical trials include Rosenecker et al., Infection 24:1 5-10 (1996); Sterman et al., Hum.", "Gene Ther.", "9:7 1083-1089 (1998); Welsh et al., Hum.", "Gene Ther.", "2:205-18 (1995); Alvarez et al., Hum.", "Gene Ther.", "5:597-613 (1997); Topf et al., Gene Ther.", "5:507-513 (1998); Sterman et al., Hum.", "Gene Ther.", "7:1083-1089 (1998).", "Packaging cells are used to form virus particles that are capable of infecting a host cell.", "Such cells include 293 cells, which package adenovirus, and ψ2 cells or PA317 cells, which package retrovirus.", "Viral vectors used in gene therapy are usually generated by a producer cell line that packages a nucleic acid vector into a viral particle.", "The vectors typically contain the minimal viral sequences required for packaging and subsequent integration into a host (if applicable), other viral sequences being replaced by an expression cassette encoding the protein to be expressed.", "The missing viral functions are supplied in trans by the packaging cell line.", "For example, AAV vectors used in gene therapy typically only possess inverted terminal repeat (ITR) sequences from the AAV genome which are required for packaging and integration into the host genome.", "Viral DNA is packaged in a cell line, which contains a helper plasmid encoding the other AAV genes, namely rep and cap, but lacking ITR sequences.", "The cell line is also infected with adenovirus as a helper.", "The helper virus promotes replication of the AAV vector and expression of AAV genes from the helper plasmid.", "The helper plasmid is not packaged in significant amounts due to a lack of ITR sequences.", "Contamination with adenovirus can be reduced by, e.g., heat treatment to which adenovirus is more sensitive than AAV.", "In many gene therapy applications, it is desirable that the gene therapy vector be delivered with a high degree of specificity to a particular tissue type.", "Accordingly, a viral vector can be modified to have specificity for a given cell type by expressing a ligand as a fusion protein with a viral coat protein on the outer surface of the virus.", "The ligand is chosen to have affinity for a receptor known to be present on the cell type of interest.", "For example, Han et al., Proc.", "Natl.", "Acad.", "Sci.", "USA 92:9747-9751 (1995), reported that Moloney murine leukemia virus can be modified to express human heregulin fused to gp70, and the recombinant virus infects certain human breast cancer cells expressing human epidermal growth factor receptor.", "This principle can be extended to other virus-target cell pairs, in which the target cell expresses a receptor and the virus expresses a fusion protein comprising a ligand for the cell-surface receptor.", "For example, filamentous phage can be engineered to display antibody fragments (e.g., FAB or Fv) having specific binding affinity for virtually any chosen cellular receptor.", "Although the above description applies primarily to viral vectors, the same principles can be applied to nonviral vectors.", "Such vectors can be engineered to contain specific uptake sequences which favor uptake by specific target cells.", "Gene therapy vectors can be delivered in vivo by administration to an individual subject, typically by systemic administration (e.g., intravenous, intraperitoneal, intramuscular, subdermal, or intracranial infusion) or topical application, as described below.", "Alternatively, vectors can be delivered to cells ex vivo, such as cells explanted from an individual patient (e.g., lymphocytes, bone marrow aspirates, tissue biopsy) or universal donor hematopoietic stem cells, followed by reimplantation of the cells into a patient, usually after selection for cells which have incorporated the vector.", "Vectors (e.g., retroviruses, adenoviruses, liposomes, etc.)", "containing nucleases and/or donor constructs can also be administered directly to an organism for transduction of cells in vivo.", "Alternatively, naked DNA can be administered.", "Administration is by any of the routes normally used for introducing a molecule into ultimate contact with blood or tissue cells including, but not limited to, injection, infusion, topical application and electroporation.", "Suitable methods of administering such nucleic acids are available and well known to those of skill in the art, and, although more than one route can be used to administer a particular composition, a particular route can often provide a more immediate and more effective reaction than another route.", "Vectors suitable for introduction of polynucleotides described herein include non-integrating lentivirus vectors (IDLV).", "See, for example, Ory et al., (1996) Proc.", "Natl.", "Acad.", "Sci.", "USA 93:11382-11388; Dull et al., (1998) J. Virol.", "72:8463-8471; Zuffery et al., (1998) J. Virol.", "72:9873-9880; Follenzi et al., (2000) Nature Genetics 25:217-222; U.S. Patent Publication No.", "2009/054985.Pharmaceutically acceptable carriers are determined in part by the particular composition being administered, as well as by the particular method used to administer the composition.", "Accordingly, there is a wide variety of suitable formulations of pharmaceutical compositions available, as described below (see, e.g., Remington's Pharmaceutical Sciences, 17th ed., 1989).", "It will be apparent that the nuclease-encoding sequences and donor constructs can be delivered using the same or different systems.", "For example, a donor polynucleotide can be carried by a plasmid, while the one or more nucleases can be carried by a AAV vector.", "Furthermore, the different vectors can be administered by the same or different routes (intramuscular injection, tail vein injection, other intravenous injection, intraperitoneal administration and/or intramuscular injection.", "The vectors can be delivered simultaneously or in any sequential order.", "Formulations for both ex vivo and in vivo administrations include suspensions in liquid or emulsified liquids.", "The active ingredients often are mixed with excipients which are pharmaceutically acceptable and compatible with the active ingredient.", "Suitable excipients include, for example, water, saline, dextrose, glycerol, ethanol or the like, and combinations thereof.", "In addition, the composition may contain minor amounts of auxiliary substances, such as, wetting or emulsifying agents, pH buffering agents, stabilizing agents or other reagents that enhance the effectiveness of the pharmaceutical composition.", "Plant Delivery As noted above, DNA and/or RNA may be introduced into (e.g., into the genome of) a desired plant host by a variety of conventional techniques.", "For reviews of such techniques see, for example, Weissbach & Weissbach Methods for Plant Molecular Biology (1988, Academic Press, N.Y.) Section VIII, pp.", "421-463; and Grierson & Corey, Plant Molecular Biology (1988, 2d Ed.", "), Blackie, London, Ch.", "7-9.See, also, U.S. Patent Publication Nos.", "2009/0205083; 2010/0199389; 2011/0167521; and 2011/0189775, incorporated herein by reference in their entireties.", "For example, polynucleotides may be introduced directly into the genomic DNA of the plant cell using techniques such as electroporation and microinjection of plant cell protoplasts, or the polynucleotides can be introduced directly to plant tissue using biolistic methods, such as DNA particle bombardment (see, e.g., Klein et al., (1987) Nature 327:70-73).", "Alternatively, the polynucleotide(s) can be introduced into the plant cell via nanoparticle transformation (see, e.g., U.S. Patent Publication No.", "2009/0104700, which is incorporated herein by reference in its entirety).", "Alternatively, the DNA/RNA constructs may be combined with suitable T-DNA border/flanking regions and introduced into a conventional Agrobacterium tumefaciens host vector.", "Agrobacterium tumefaciens-mediated transformation techniques, including disarming of oncogenes and the development and use of binary vectors, are well described in the scientific literature.", "See, for example Horsch et al., (1984) Science 233:496-498, and Fraley et al., (1983) Proc.", "Nat'l.", "Acad.", "Sci.", "USA80:4803.In addition, gene transfer may be achieved using non-Agrobacterium bacteria or viruses such as Rhizobium sp.", "NGR234, Sinorhizoboium meliloti, Mesorhizobium loti, potato virus X, cauliflower mosaic virus and cassava vein mosaic virus and/or tobacco mosaic virus, See, e.g., Chung et al., (2006) Trends Plant Sci.", "11(1):1-4.The virulence functions of the Agrobacterium tumefaciens host will direct the insertion of a T-strand containing the construct and adjacent marker into the plant cell DNA when the cell is infected by the bacteria using binary T-DNA vector (Bevan (1984) Nuc.", "Acid Res.", "12:8711-8721) or the co-cultivation procedure (Horsch et al., (1985) Science 227:1229-1231).", "Generally, the Agrobacterium transformation system is used to engineer dicotyledonous plants (Bevan et al., (1982) Ann.", "Rev.", "Genet 16:357-384; Rogers et al., (1986) Methods Enzymol.", "118:627-641).", "The Agrobacterium transformation system may also be used to transform, as well as transfer, polynucleotides to monocotyledonous plants and plant cells.", "See U.S. Pat.", "No.", "5,591,616; Hernalsteen et al., (1984) EMBO J 3:3039-3041; Hooykass-Van Slogteren et al., (1984) Nature 311:763-764; Grimsley et al., (1987) Nature 325:1677-179; Boulton et al., (1989) Plant Mol.", "Biol.", "12:31-40; and Gould et al., (1991) Plant Physiol.", "95:426-434.Alternative gene transfer and transformation methods include, but are not limited to, protoplast transformation through calcium-, polyethylene glycol (PEG)- or electroporation-mediated uptake of naked DNA/RNA (see Paszkowski et al., (1984) EMBO J 3:2717-2722, Potrykus et al., (1985) Molec.", "Gen. Genet.", "199:169-177; Fromm et al., (1985) Proc.", "Nat.", "Acad.", "Sci.", "USA 82:5824-5828; and Shimamoto (1989) Nature 338:274-276) and electroporation of plant tissues (D'Halluin et al., (1992) Plant Cell 4:1495-1505).", "Additional methods for plant cell transformation include microinjection, silicon carbide (e.g., WHISKERS™) mediated DNA uptake (Kaeppler et al., (1990) Plant Cell Reporter 9:415-418), and microprojectile bombardment (see Klein et al., (1988) Proc.", "Nat.", "Acad.", "Sci.", "USA 85:4305-4309; and Gordon-Kamm et al., (1990) Plant Cell 2:603-618).", "Transformed plant cells which are produced by any of the above transformation techniques can be cultured to regenerate a whole plant which possesses the transformed genotype and thus the desired phenotype.", "Such regeneration techniques rely on manipulation of certain phytohormones in a tissue culture growth medium, typically relying on a biocide and/or herbicide marker which has been introduced together with the desired nucleotide sequences.", "Plant regeneration from cultured protoplasts is described in Evans, et al., “Protoplasts Isolation and Culture” in Handbook of Plant Cell Culture, pp.", "124-176, Macmillian Publishing Company, New York, 1983; and Binding, Regeneration of Plants, Plant Protoplasts, pp.", "21-73, CRC Press, Boca Raton, 1985.Regeneration can also be obtained from plant callus, explants, organs, pollens, embryos or parts thereof.", "Such regeneration techniques are described generally in Klee et al., (1987) Ann.", "Rev.", "of Plant Phys.", "38:467-486.Nucleic acids introduced into a plant cell can be used to confer desired traits on essentially any plant.", "A wide variety of plants and plant cell systems may be engineered for the desired physiological and agronomic characteristics described herein using the nucleic acid constructs of the present disclosure and the various transformation methods mentioned above.", "In preferred embodiments, target plants and plant cells for engineering include, but are not limited to, those monocotyledonous and dicotyledonous plants, such as crops including grain crops (e.g., wheat, maize, rice, millet, barley), fruit crops (e.g., tomato, apple, pear, strawberry, orange), forage crops (e.g., alfalfa), root vegetable crops (e.g., carrot, potato, sugar beets, yam), leafy vegetable crops (e.g., lettuce, spinach); flowering plants (e.g., petunia, rose, chrysanthemum), conifers and pine trees (e.g., pine fir, spruce); plants used in phytoremediation (e.g., heavy metal accumulating plants); oil crops (e.g., sunflower, rape seed) and plants used for experimental purposes (e.g., Arabidopsis).", "Thus, the disclosed methods and compositions have use over a broad range of plants, including, but not limited to, species from the genera Asparagus, Avena, Brassica, Citrus, Citrullus, Capsicum, Cucurbita, Daucus, Erigeron, Glycine, Gossypium, Hordeum, Lactuca, Lolium, Lycopersicon, Malus, Manihot, Nicotiana, Orychophragmus, Oryza, Persea, Phaseolus, Pisum, Pyrus, Prunus, Raphanus, Secale, Solanum, Sorghum, Triticum, Vitis, Vigna, and Zea.", "The introduction of nucleic acids introduced into a plant cell can be used to confer desired traits on essentially any plant.", "In certain embodiments, the altered MDH expression/function in plant cells results in plants having increased amount of fruit yield, increased biomass of plant (or fruit of the plant), higher content of fruit flesh, concentrated fruit set, larger plants, increased fresh weight, increased dry weight, increased solids context, higher total weight at harvest, enhanced intensity and/or uniformity of color of the crop, altered chemical (e.g., oil, fatty acid, carbohydrate, protein) characteristics, etc.", "One with skill in the art will recognize that an exogenous sequence can be transiently incorporated into a plant cell.", "The introduction of an exogenous polynucleotide sequence can utilize the cell machinery of the plant cell in which the sequence has been introduced.", "The expression of an exogenous polynucleotide sequence comprising a ZFN that is transiently incorporated into a plant cell can be assayed by analyzing the genomic DNA of the target sequence to identify and determine any indels, inversions, or insertions.", "These types of rearrangements result from the cleavage of the target site within the genomic DNA sequence, and the subsequent DNA repair.", "In addition, the expression of an exogenous polynucleotide sequence can be assayed using methods which allow for the testing of marker gene expression known to those of ordinary skill in the art.", "Transient expression of marker genes has been reported using a variety of plants, tissues, and DNA delivery systems.", "Transient analyses systems include but are not limited to direct gene delivery via electroporation or particle bombardment of tissues in any transient plant assay using any plant species of interest.", "Such transient systems would include but are not limited to electroporation of protoplasts from a variety of tissue sources or particle bombardment of specific tissues of interest.", "The present disclosure encompasses the use of any transient expression system to evaluate a site specific endonuclease (e.g., ZFN) and to introduce mutations within an MDH target gene.", "Examples of plant tissues envisioned to test in transients via an appropriate delivery system would include but are not limited to leaf base tissues, callus, cotyledons, roots, endosperm, embryos, floral tissue, pollen, and epidermal tissue.", "One of skill in the art will recognize that an exogenous polynucleotide sequence can be stably incorporated in transgenic plants.", "Once the exogenous polynucleotide sequence is confirmed to be operable, it can be introduced into other plants by sexual crossing.", "Any of a number of standard breeding techniques can be used, depending upon the species to be crossed.", "A transformed plant cell, callus, tissue or plant may be identified and isolated by selecting or screening the engineered plant material for traits encoded by the marker genes present on the transforming DNA.", "For instance, selection can be performed by growing the engineered plant material on media containing an inhibitory amount of the antibiotic or herbicide to which the transforming gene construct confers resistance.", "Further, transformed plants and plant cells can also be identified by screening for the activities of any visible marker genes (e.g., the β-glucuronidase, luciferase, B or C1 genes) that may be present on the recombinant nucleic acid constructs.", "Such selection and screening methodologies are well known to those skilled in the art.", "Physical and biochemical methods also may be used to identify plant or plant cell transformants containing stably inserted gene constructs, or plant cell containing target gene altered genomic DNA which results from the transient expression of a site-specific endonuclease (e.g., ZFN).", "These methods include but are not limited to: 1) Southern analysis or PCR amplification for detecting and determining the structure of the recombinant DNA insert; 2) Northern blot, 51 RNase protection, primer-extension or reverse transcriptase-PCR amplification for detecting and examining RNA transcripts of the gene constructs; 3) enzymatic assays for detecting enzyme or ribozyme activity, where such gene products are encoded by the gene construct; 4) protein gel electrophoresis, Western blot techniques, immunoprecipitation, or enzyme-linked immunoassays (ELISA), where the gene construct products are proteins.", "Additional techniques, such as in situ hybridization, enzyme staining, and immunostaining, also may be used to detect the presence or expression of the recombinant construct in specific plant organs and tissues.", "The methods for doing all these assays are well known to those skilled in the art.", "Effects of gene manipulation using the methods disclosed herein can be observed by, for example, northern blots of the RNA (e.g., mRNA) isolated from the tissues of interest.", "Typically, if the mRNA is present or the amount of mRNA has increased, it can be assumed that the corresponding transgene is being expressed.", "Other methods of measuring gene and/or encoded polypeptide activity can be used.", "Different types of enzymatic assays can be used, depending on the substrate used and the method of detecting the increase or decrease of a reaction product or by-product.", "In addition, the levels of polypeptide expressed can be measured immunochemically, i.e., ELISA, RIA, EIA and other antibody based assays well known to those of skill in the art, such as by electrophoretic detection assays (either with staining or western blotting).", "As one non-limiting example, the detection of the AAD-1 and PAT proteins using an ELISA assay is described in U.S. Patent Publication No.", "2009/0093366, which reference is hereby incorporated by reference in its entirety herein.", "A transgene may be selectively expressed in some tissues of the plant or at some developmental stages, or the transgene may be expressed in substantially all plant tissues, substantially along its entire life cycle.", "However, any combinatorial expression mode is also applicable.", "The present disclosure also encompasses seeds of the transgenic plants described above wherein the seed has the transgene or gene construct.", "The present disclosure further encompasses the progeny, clones, cell lines or cells of the transgenic plants described above wherein said progeny, clone, cell line or cell has the transgene or gene construct.", "Fusion proteins (e.g., ZFNs) and expression vectors encoding fusion proteins can be administered directly to the plant for gene regulation, targeted cleavage, and/or recombination.", "In certain embodiments, the plant contains multiple paralogous MDH target genes.", "Thus, one or more different fusion proteins or expression vectors encoding fusion proteins may be administered to a plant in order to target one or more of these paralogous genes in the plant.", "Administration of effective amounts is by any of the routes normally used for introducing fusion proteins into ultimate contact with the plant cell to be treated.", "The ZFPs are administered in any suitable manner, preferably with acceptable carriers.", "Suitable methods of administering such modulators are available and well known to those of skill in the art, and, although more than one route can be used to administer a particular composition, a particular route can often provide a more immediate and more effective reaction than another route.", "Carriers may also be used and are determined in part by the particular composition being administered, as well as by the particular method used to administer the composition.", "Accordingly, there is a wide variety of suitable formulations of carriers that are available.", "EXAMPLES Example 1: Designing of sgRNAs The sequence of the guide RNA (sgRNA or gRNA) for use in genome editing of a given ZFN-specified locus was identified by: (i) aligning the recognition sequence of the ZFN heterodimer with the reference sequence of the relevant genome (human, mouse, or of a particular plant species); (ii) identifying the spacer region between the ZFN half-sites; (iii) identifying the location of the motif G[N20]GG that is closest to the spacer region (when more than one such motif overlapped the spacer, the motif that is centered relative to the spacer was chosen); (iv) using that motif as the core of the gRNA.", "Table 1 shows a series of sgRNAs for use with the CRISPR/Cas system.", "Cells of interest are contacted with the sgRNAs in Table 1 and are engineered.", "TABLE 1 sgRNAs designed to target ZFN target sequences Target Seq Seq gene Target sequence for ZFN ID NO: Sequence encoding sgRNA ID NO: Human β GGGCAGTAACGGCAGACTTCTCCTCAGG 1 GTCTGCCGTTACTGCCCTGTGGG 149 globin TGGGGCAAGGTGAACGTGGATGAAGTTG 2 GTCTGCCGTTACTGCCCTGTGGG 149 ″ AGAGTCAGGTGCACCATGGTGTCTGTTT 3 GTAACGGCAGACTTCaCCTCAGG 150 ″ GTGGAGAAGTCTGCCGTTACTGCCCTGT 4 GTAACGGCAGACTTCaCCTCAGG 150 ″ ACAGGAGTCAGGTGCACCATGGTGTCTG 5 GTAACGGCAGACTTCaCCTCAGG 150 ″ GAGAAGTCTGCCGTTACTGCCCTGTGGG 6 GTAACGGCAGACTTCaCCTCAGG 150 ″ TAACGGCAGACTTCTCCACAGGAGTCAG 7 GTAACGGCAGACTTCaCCTCAGG 150 ″ GCCCTGTGGGGCAAGGTGAACGTGGATG 8 GTAACGGCAGACTTCaCCTCAGG 150 ″ GGGCAGTAACGGCAGACTTCTCCTCAGG 1 GTAACGGCAGACTTCaCCTCAGG 150 ″ TGGGGCAAGGTGAACGTGGATGAAGTTG 2 GTAACGGCAGACTTCaCCTCAGG 150 ″ CACAGGGCAGTAACGGCAGACTTCTCCT 9 GTAACGGCAGACTTCaCCTCAGG 150 ″ GGCAAGGTGAACGTGGATGAAGTTGGTG 10 GTAACGGCAGACTTCaCCTCAGG 150 Human ATCCCATGGAGAGGTGGCTGGGAAGGAC 11 GCAATATGAATCCCATGGAGAGG 151 BCL11A ATATTGCAGACAATAACCCCTTTAACCT 12 GCAATATGAATCCCATGGAGAGG 151 ″ CATCCCAGGCGTGGGGATTAGAGCTCCA 13 GCATATTCTGCACTCATCCCAGG 152 ″ GTGCAGAATATGCCCCGCAGGGTATTTG 14 GCATATTCTGCACTCATCCCAGG 152 Human GGGAAGGGGCCCAGGGCGGTCAGTGTGC 15 GGGCCCCTTCCCGGACACACAGG 153 KLF1 ACACACAGGATGACTTCCTCAAGGTGGG 16 GGGCCCCTTCCCGGACACACAGG 153 ″ CGCCACCGGGCTCCGGGCCCGAGAAGTT 17 GCAGGTCTGGGGCGCGCCACCGG 154 ″ CCCCAGACCTGCGCTCTGGCGCCCAGCG 18 GCAGGTCTGGGGCGCGCCACCGG 154 ″ GGCTCGGGGGCCGGGGCTGGAGCCAGGG 19 GGCCCCCGAGCCCAAGGCGCTGG 155 ″ AAGGCGCTGGCGCTGCAACCGGTGTACC 20 GGCCCCCGAGCCCAAGGCGCTGG 155 ″ TTGCAGCGCCAGCGCCTTGGGCTCGGGG 21 GCGCTGCAACCGGTGTACCCGGG 156 ″ CGGTGTACCCGGGGCCCGGCGCCGGCTC 22 GCGCTGCAACCGGTGTACCCGGG 156 Human γ TTGCATTGAGATAGTGTGGGGAAGGGGC 23 GCATTGAGATAGTGTGGGGAAGG 157 regulatory ATCTGTCTGAAACGGTCCCTGGCTAAAC 24 GCATTGAGATAGTGTGGGGAAGG 157 ″ TTTGCATTGAGATAGTGTGGGGAAGGGG 25 GCATTGAGATAGTGTGGGGAAGG 157 ″ CTGTCTGAAACGGTCCCTGGCTAAACTC 26 GCATTGAGATAGTGTGGGGAAGG 157 ″ TATTTGCATTGAGATAGTGTGGGGAAGG 27 GCATTGAGATAGTGTGGGGAAGG 157 ″ CTGTCTGAAACGGTCCCTGGCTAAACTC 26 GCATTGAGATAGTGTGGGGAAGG 157 ″ CTTGACAAGGCAAAC 28 GCTATTGGTCAAGGCAAGGCTGG 158 ″ GTCAAGGCAAGGCTG 29 GCTATTGGTCAAGGCAAGGCTGG 158 Human GATGAGGATGAC 30 GTGTTCATCTTTGGTTTTGTGGG 159 CCR5 GATGAGGATGAC 30 GTGTTCATCTTTGGTTTTGTGGG 159 ″ GATGAGGATGAC 30 GTGTTCATCTTTGGTTTTGTGGG 159 ″ GATGAGGATGAC 30 GTGTTCATCTTTGGTTTTGTGGG 159 ″ GATGAGGATGAC 30 GTGTTCATCTTTGGTTTTGTGGG 159 ″ GATGAGGATGAC 30 GTGTTCATCTTTGGTTTTGTGGG 159 ″ GATGAGGATGAC 30 GTGTTCATCTTTGGTTTTGTGGG 159 ″ AAACTGCAAAAG 31 GTGTTCATCTTTGGTTTTGTGGG 159 ″ AAACTGCAAAAG 31 GTGTTCATCTTTGGTTTTGTGGG 159 ″ AAACTGCAAAAG 31 GTGTTCATCTTTGGTTTTGTGGG 159 ″ AAACTGCAAAAG 31 GTGTTCATCTTTGGTTTTGTGGG 159 ″ AAACTGCAAAAG 31 GTGTTCATCTTTGGTTTTGTGGG 159 ″ AAACTGCAAAAG 31 GTGTTCATCTTTGGTTTTGTGGG 159 ″ AAACTGCAAAAG 31 GTGTTCATCTTTGGTTTTGTGGG 159 ″ GACAAGCAGCGG 32 GGTCCTGCCGCTGCTTGTCATGG 160 ″ CATCTGCTACTCG 33 GGTCCTGCCGCTGCTTGTCATGG 160 Human ATGACTTGTGGGTGGTTGTGTTCCAGTT 34 GCTTCTACCCCAATGACTTGTGG 161 CXCR4 GGGTAGAAGCGGTCACAGATATATCTGT 35 GCTTCTACCCCAATGACTTGTGG 161 ″ AGTCAGAGGCCAAGGAAGCTGTTGGCTG 36 GCCTCTGACTGTTGGTGGCGTGG 162 ″ TTGGTGGCGTGGACGATGGCCAGGTAGC 37 GCCTCTGACTGTTGGTGGCGTGG 162 ″ CAGTTGATGCCGTGGCAAACTGGTACTT 38 GCCGTGGCAAACTGGTACTTTGG 163 ″ CCAGAAGGGAAGCGTGATGACAAAGAGG 39 GCCGTGGCAAACTGGTACTTTGG 163 PPP1R ACTAGGGACAGGATTG 40 GGGGCCACTAGGGACAGGATTGG 164 12C CCCCACTGTGGGGTGG 41 GGGGCCACTAGGGACAGGATTGG 164 PPP1R ACTAGGGACAGGATTG 40 GTCACCAATCCTGTCCCTAGTGG 165 12C CCCCACTGTGGGGTGG 41 GTCACCAATCCTGTCCCTAGTGG 165 PPP1R ACTAGGGACAGGATTG 40 GTGGCCCCACTGTGGGGTGGAGG 166 12C CCCCACTGTGGGGTGG 41 GTGGCCCCACTGTGGGGTGGAGG 166 Mouse ACCCGCAGTCCCAGCGTCGTGGTGAGCC 42 GTCGGCATGACGGGACCGGTCGG 167 and GCATGACGGGACCGGTCGGCTCGCGGCA 43 GTCGGCATGACGGGACCGGTCGG 167 Human TGATGAAGGAGATGGGAGGCCATCACAT 44 GATGTGATGAAGGAGATGGGAGG 168 HPRT ATCTCGAGCAAGACGTTCAGTCCTACAG 45 GATGTGATGAAGGAGATGGGAGG 168 ″ AAGCACTGAATAGAAATAGTGATAGATC 46 GTGCTTTGATGTAATCCAGCAGG 169 ″ ATGTAATCCAGCAGGTCAGCAAAGAATT 47 GTGCTTTGATGTAATCCAGCAGG 169 ″ GGCCGGCGCGCGGGCTGACTGCTCAGGA 48 GTCGCCATAACGGAGCCGGCCGG 170 ″ GCTCCGTTATGGCGACCCGCAGCCCTGG 49 GTCGCCATAACGGAGCCGGCCGG 170 ″ TGCAAAAGGTAGGAAAAGGACCAACCAG 50 GTATTGCAAAAGGTAGGAAAAGG 171 ″ ACCCAGATACAAACAATGGATAGAAAAC 51 GTATTGCAAAAGGTAGGAAAAGG 171 ″ CTGGGATGAACTCTGGGCAGAATTCACA 52 GCATATCTGGGATGAACTCTGGG 172 ″ ATGCAGTCTAAGAATACAGACAGATCAG 53 GCATATCTGGGATGAACTCTGGG 172 ″ TGCACAGGGGCTGAAGTTGTCCCACAGG 54 GCCTCCTGGCCATGTGCACAGGG 173 ″ TGGCCAGGAGGCTGGTTGCAAACATTTT 55 GCCTCCTGGCCATGTGCACAGGG 173 ″ TTGAATGTGATTTGAAAGGTAATTTAGT 56 GAAGCTGATGATTTAAGCTTTGG 174 ″ AAGCTGATGATTTAAGCTTTGGCGGTTT 57 GAAGCTGATGATTTAAGCTTTGG 174 ″ GTGGGGTAATTGATCCATGTATGCCATT 58 GATCAATTACCCCACCTGGGTGG 175 ″ GGGTGGCCAAAGGAACTGCGCGAACCTC 59 GATCAATTACCCCACCTGGGTGG 175 ″ ATCAACTGGAGTTGGACTGTAATACCAG 60 GATGTCTTTACAGAGACAAGAGG 176 ″ CTTTACAGAGACAAGAGGAATAAAGGAA 61 GATGTCTTTACAGAGACAAGAGG 176 Human CCTATCCATTGCACTATGCTTTATTTAA 62 GATCAACAGCACAGGTTTTGTGG 177 albumin CCTATCCATTGCACTATGCTTTATTTAA 62 GATCAACAGCACAGGTTTTGTGG 177 ″ CCTATCCATTGCACTATGCTTTATTTAA 62 GATCAACAGCACAGGTTTTGTGG 177 ″ CCTATCCATTGCACTATGCTTTATTTAA 62 GATCAACAGCACAGGTTTTGTGG 177 ″ CCTATCCATTGCACTATGCTTTATTTAA 62 GATCAACAGCACAGGTTTTGTGG 177 ″ CCTATCCATTGCACTATGCTTTATTTAA 62 GATCAACAGCACAGGTTTTGTGG 177 ″ TTTGGGATAGTTATGAATTCAATCTTCA 63 GATCAACAGCACAGGTTTTGTGG 177 ″ TTTGGGATAGTTATGAATTCAATCTTCA 63 GATCAACAGCACAGGTTTTGTGG 177 ″ TTTGGGATAGTTATGAATTCAATCTTCA 63 GATCAACAGCACAGGTTTTGTGG 177 ″ TTTGGGATAGTTATGAATTCAATCTTCA 63 GATCAACAGCACAGGTTTTGTGG 177 ″ CCTGTGCTGTTGATCTCATAAATAGAAC 64 GATCAACAGCACAGGTTTTGTGG 177 ″ CCTGTGCTGTTGATCTCATAAATAGAAC 64 GATCAACAGCACAGGTTTTGTGG 177 ″ TTGTGGTTTTTAAATAAAGCATAGTGCA 65 GATCAACAGCACAGGTTTTGTGG 177 ″ TTGTGGTTTTTAAATAAAGCATAGTGCA 65 GATCAACAGCACAGGTTTTGTGG 177 ″ ACCAAGAAGACAGACTAAAATGAAAATA 66 GATCAACAGCACAGGTTTTGTGG 177 ″ CTGTTGATAGACACTAAAAGAGTATTAG 67 GATCAACAGCACAGGTTTTGTGG 177 Human TGACACAGTACCTGGCACCATAGTTGTA 68 GTCAGGGTACTAGGGGTATGGGG 178 Factor GTACTAGGGGTATGGGGATAAACCAGAC 69 GTCAGGGTACTAGGGGTATGGGG 178 IX Human GCAAAGATTGCTGACTACGGCATTGCTC 70 GTCAGCAATCTTTGCAATGATGG 179 LRRK2 TGATGGCAGCATTGGGATACAGTGTGAA 71 GTCAGCAATCTTTGCAATGATGG 179 ″ GCAAAGATTGCTGACTACAGCATTGCTC 72 GTCAGCAATCTTTGCAATGATGG 179 Human GGGGCGATGCTGGGGACGGGGACATTAG 73 ?", "Htt ACGCTGCGCCGGCGGAGGCGGGGCCGCG 74 GTCTGGGACGCAAGGCGCCGTGG 180 ″ AAGGCGCCGTGGGGGCTGCCGGGACGGG 75 GTCTGGGACGCAAGGCGCCGTGG 180 ″ AGTCCCCGGAGGCCTCGGGCCGACTCGC 76 GGAGGCCTCGGGCCGACTCGCGG 181 ″ GCGCTCAGCAGGTGGTGACCTTGTGGAC 77 GCCGGTGATATGGGCTTCCTGGG 182 ″ ATGGTGGGAGAGACTGTGAGGCGGCAGC 78 GAGACTGTGAGGCGGCAGCTGGG 183 ″ ATGGCGCTCAGCAGGTGGTGACCTTGTG 79 GAGACTGTGAGGCGGCAGCTGGG 183 ″ TGGGAGAGACTGTGAGGCGGCAGCTGGG 80 GAGACTGTGAGGCGGCAGCTGGG 183 Human GCCAGGTAGTACTGTGGGTACTCGAAGG 81 GGCTCAGCCAGGTAGTACTGTGG 184 RHO GAGCCATGGCAGTTCTCCATGCTGGCCG 82 GGCTCAGCCAGGTAGTACTGTGG 184 ″ CAGTGGGTTCTTGCCGCAGCAGATGGTG 83 GAACCCACTGGGTGACGATGAGG 185 ″ GTGACGATGAGGCCTCTGCTACCGTGTC 84 GAACCCACTGGGTGACGATGAGG 185 ″ GGGGAGACAGGGCAAGGCTGGCAGAGAG 85 GCCCTGTCTCCCCCATGTCCAGG 186 ″ ATGTCCAGGCTGCTGCCTCGGTCCCATT 86 GCCCTGTCTCCCCCATGTCCAGG 186 CFTR ATTAGAAGTGAAGTCTGGAAATAAAACC 87 GGGAGAACTGGAGCCTTCAGAGG 187 ″ AGTGATTATGGGAGAACTGGATGTTCACAG 88 GGGAGAACTGGAGCCTTCAGAGG 187 TCAGTCCACACGTC ″ CATCATAGGAAACACCAAAGATGATATT 89 GAGGGTAAAATTAAGCACAGTGG 188 ″ ATATAGATACAGAAGCGTCATCAAAGCA 90 GAGGGTAAAATTAAGCACAGTGG 188 ″ GCTTTGATGACGCTTCTGTATCTATATT 91 GAGGGTAAAATTAAGCACAGTGG 188 ″ CCAACTAGAAGAGGTAAGAAACTATGTG 92 GAGGGTAAAATTAAGCACAGTGG 188 ″ CCTATGATGAATATAGATACAGAAGCGT 93 GAGGGTAAAATTAAGCACAGTGG 188 ″ ACACCAATGATATTTTCTTTAATGGTGC 94 GAGGGTAAAATTAAGCACAGTGG 188 TRAC CTATGGACTTCAAGAGCAACAGTGCTGT 95 GAGAATCAAAATCGGTGAATAGG 189 ″ CTCATGTCTAGCACAGTTTTGTCTGTGA 96 GAGAATCAAAATCGGTGAATAGG 189 ″ GTGCTGTGGCCTGGAGCAACAAATCTGA 97 GAGAATCAAAATCGGTGAATAGG 189 ″ TTGCTCTTGAAGTCCATAGACCTCATGT 98 GAGAATCAAAATCGGTGAATAGG 189 ″ GCTGTGGCCTGGAGCAACAAATCTGACT 99 GACACCTTCTTCCCCAGCCCAGG 190 ″ CTGTTGCTCTTGAAGTCCATAGACCTCA 100 GACACCTTCTTCCCCAGCCCAGG 190 ″ CTGTGGCCTGGAGCAACAAATCTGACTT 101 GACACCTTCTTCCCCAGCCCAGG 190 ″ CTGACTTTGCATGTGCAAACGCCTTCAA 102 GACACCTTCTTCCCCAGCCCAGG 190 ″ TTGTTGCTCCAGGCCACAGCACTGTTGC 103 GACACCTTCTTCCCCAGCCCAGG 190 ″ TGAAAGTGGCCGGGTTTAATCTGCTCAT 104 GACACCTTCTTCCCCAGCCCAGG 190 ″ AGGAGGATTCGGAACCCAATCACTGACA 105 GATTAAACCCGGCCACTTTCAGG 191 ″ GAGGAGGATTCGGAACCCAATCACTGAC 106 GATTAAACCCGGCCACTTTCAGG 191 ″ TGAAAGTGGCCGGGTTTAATCTGCTCAT 104 GATTAAACCCGGCCACTTTCAGG 191 TRBC CCGTAGAACTGGACTTGACAGCGGAAGT 107 GCTGTCAAGTCCAGTTCTACGGG 192 ″ TCTCGGAGAATGACGAGTGGACCCAGGA 108 GCTGTCAAGTCCAGTTCTACGGG 192 ″ TCTCGGAGAATGACGAGTGGACCCAGGA 108 GCTGTCAAGTCCAGTTCTACGGG 192 ″ TCTCGGAGAATGACGAGTGGACCCAGGA 108 GCTGTCAAGTCCAGTTCTACGGG 192 ″ TCTCGGAGAATGACGAGTGGACCCAGGA 108 GCTGTCAAGTCCAGTTCTACGGG 192 ″ CCGTAGAACTGGACTTGACAGCGGAAGT 107 GCTGTCAAGTCCAGTTCTACGGG 192 ″ CCGTAGAACTGGACTTGACAGCGGAAGT 107 GCTGTCAAGTCCAGTTCTACGGG 192 ″ CCGTAGAACTGGACTTGACAGCGGAAGT 107 GCTGTCAAGTCCAGTTCTACGGG 192 ″ CCGTAGAACTGGACTTGACAGCGGAAGT 107 GCTGTCAAGTCCAGTTCTACGGG 192 Human CCAGGGCGCCTGTGGGATCTGCATGCCT 109 GGCGCCCTGGCCAGTCGTCTGGG 193 PD1 CAGTCGTCTGGGCGGTGCTACAACTGGG 110 GGCGCCCTGGCCAGTCGTCTGGG 193 ″ GAACACAGGCACGGCTGAGGGGTCCTCC 111 GTCCACAGAGAACACAGGCACGG 194 ″ CTGTGGACTATGGGGAGCTGGATTTCCA 112 GTCCACAGAGAACACAGGCACGG 194 ″ CAGTCGTCTGGGCGGTGCT 113 GGCGCCCTGGCCAGTCGTCTGGG 193 Human ACAGTGCTTCGGCAGGCTGACAGCCAGG 114 GCTTCGGCAGGCTGACAGCCAGG 195 CTLA- ACCCGGACCTCAGTGGCTTTGCCTGGAG 115 GCTTCGGCAGGCTGACAGCCAGG 195 4 ACTACCTGGGCATAGGCAACGGAACCCA 116 GTACCCACCGCCATACTACCTGG 196 ″ TGGCGGTGGGTACATGAGCTCCACCTTG 117 GTACCCACCGCCATACTACCTGG 196 HLA Cl1: GTATGGCTGCGACGTGGGGTCGGACGGG 118 GCTGCGACGTGGGGTCGGACGGG 197 HLA TTATCTGGATGGTGTGAGAACCTGGCCC 119 GCAGCCATACATTATCTGGATGG 198 A2 TCCTCTGGACGGTGTGAGAACCTGGCCC 120 GCAGCCATACATCCTCTGGACGG 199 HLA ATGGAGCCGCGGGCGCCGTGGATAGAGC 121 GTGGATAGAGCAGGAGGGGCCGG 200 A3 CTGGCTCGCGGCGTCGCTGTCGAACCGC 122 GAGCCAGAGGATGGAGCCGCGGG 201 HLA B TCCAGGAGCTCAGGTCCTCGTTCAGGGC 123 GGACCTGAGCTCCTGGACCGCGG 202 ″ CGGCGGACACCGCGGCTCAGATCACCCA 124 GGACCTGAGCTCCTGGACCGCGG 202 ″ AGGTGGATGCCCAGGACGAGCTTTGAGG 125 GATGCCCAGGACGAGCTTTGAGG 203 ″ AGGGAGCAGAAGCAGCGCAGCAGCGCCA 126 GCGCTGCTTCTGCTCCCTGGAGG 204 ″ CTGGAGGTGGATGCCCAGGACGAGCTTT 127 GCGCTGCTTCTGCTCCCTGGAGG 204 ″ GAGCAGAAGCAGCGCAGCAGCGCCACCT 128 GCGCTGCTTCTGCTCCCTGGAGG 204 HLA C CCTCAGTTTCATGGGGATTCAAGGGAAC 129 GGGGATTCAAGGGAACACCCTGG 205 ″ CCTAGGAGGTCATGGGCATTTGCCATGC 130 GCAAATGCCCATGACCTCCTAGG 206 ″ TCGCGGCGTCGCTGTCGAACCGCACGAA 131 GAGCCAGAGGATGGAGCCGCGGG 201 ″ CCAAGAGGGGAGCCGCGGGAGCCGTGGG 132 GGCGCCCGCGGCTCCCCTCTTGG 207 HLA cl.", "GAAATAAGGCATACTGGTATTACTAATG 133 GTTCACATCTCCCCCGGGCCTGG 208 II: GAGGAGAGCAGGCCGATTACCTGACCCA 134 GTTCACATCTCCCCCGGGCCTGG 208 DBP2 DRA TCTCCCAGGGTGGTTCAGTGGCAGAATT 135 GGAGAATGCGGGGGAAAGAGAGG 209 ″ GCGGGGGAAAGAGAGGAGGAGAGAAGGA 136 GGAGAATGCGGGGGAAAGAGAGG 209 TAP1 AGAAGGCTGTGGGCTCCTCAGAGAAAAT 137 GCCCACAGCCTTCTGTACTCTGG 210 ″ ACTCTGGGGTAGATGGAGAGCAGTACCT 138 GCCCACAGCCTTCTGTACTCTGG 210 TAP2 TTGCGGATCCGGGAGCAGCTTTTCTCCT 139 GTTGATTCGAGACATGGTGTAGG 211 ″ TTGATTCGAGACATGGTGTAGGTGAAGC 140 GTTGATTCGAGACATGGTGTAGG 211 Tapasin CCACAGCCAGAGCCTCAGCAGGAGCCTG 141 GCTCTGGCTGTGGTCGCAAGAGG 212 ″ CGCAAGAGGCTGGAGAGGCTGAGGACTG 142 GCTCTGGCTGTGGTCGCAAGAGG 212 ″ CTGGATGGGGCTTGGCTGATGGTCAGCA 143 GCAGAACTGCCCGCGGGCCCTGG 213 ″ GCCCGCGGGCAGTTCTGCGCGGGGGTCA 144 GCAGAACTGCCCGCGGGCCCTGG 213 CIITA GCTCCCAGGCAGCGGGCGGGAGGCTGGA 145 GCTGCCTGGGAGCCCTACTCGGG 214 ″ CTACTCGGGCCATCGGCGGCTGCCTCGG 146 GCTGCCTGGGAGCCCTACTCGGG 214 RFX5 TTGATGTCAGGGAAGATCTCTCTGATGA 147 GCCTTCGAGCTTTGATGTCAGGG 215 ″ GCTCGAAGGCTTGGTGGCCGGGGCCAGT 148 GCCTTCGAGCTTTGATGTCAGGG 215 Example 2: sgRNAs and tru-RNAs to Genes of Interest As described in Example 1, the design of an sgRNA is accomplished through a variety of considerations: (i) aligning the recognition sequence of the ZFN heterodimer with the reference sequence of the relevant genome (human, mouse, or of a particular plant species); (ii) identifying the spacer region between the ZFN half-sites; (iii) identifying the location of the PAM motif relevant to the Cas9 protein being used (for example: G[N17-20](G/A)G when using the S. pyogenes Cas9) that is closest to the spacer region (when more than one such motif overlapped the spacer, the motif that is centered relative to the spacer was chosen); (iv) using that motif as the core of the sgRNA.", "Shown below in Table 2 are exemplary genes for targeting with a CRISPR/Cas system and an sgRNA of the invention.", "Also indicated is an accession number of representative example of a cDNA associated with these genes.", "TABLE 2 Exemplary genes for targeting with a CRISPR/Cas system Representative Accession Gene name UCSC Genome Brower location (cDNA) RefSeq HBB chr11: 5246696-5248301 (NM_000518) BCL11A chr2: 60684329-60780633 (NM_022893) KLF1 chr19: 12995237-12998017 (NM_006563) HBG1 chr11: 5269502-5271087 (NM_000559) CCR5 chr3: 46411633-46417697 (NM_000579) CXCR4 chr2: 136871919-136873813 (NM_001008540) PPP1R12C chr19: 55602281-55628968 (NM_017607) HPRT chrX: 133594175-133634698 (NM_000194) Mouse HPRT chrX: 52988078-53021660 (NM_013556) (assembly GRCm38/mm10) ALB chr4: 74269972-74287129 (NM_000477) Factor VIII chrX: 154064064-154250998 (NM_000132.3) Factor IX chrX: 138612895-138645617 (NM_000133) LRRK2 chr12: 40618813-40763086 (NM_198578) Htt chr4: 3076237-3245687 (NM_002111) RHO chr3: 129247482-129254187 (NM_000539) CFTR chr7: 117120017-117308718 (NM_000492) TCRA chr6: 42883727-42893575 (NM_001243168) TCRB chr7: 142197572-142198055 L36092.2 PD-1 chr2: 242792033-242795132 (NM_005018) CTLA-4 chr2: 204732511-204738683 (NM_001037631) HLA-A chr6: 29910247-29912868 (NM_002116) HLA-B chr6: 31236526-31239913 NM_005514.6 HLA-C chr6: 31236526-31239125 (NM_001243042) HLA-DPA chr6: 33032346-33048555 (NM_033554.3) HLA-DQ chr6: 32605183-32611429 (NM_002122) HLA-DRA chr6_ssto_hap7: 3754283-3759493 (NM_019111) LMP7 chr6_dbb_hap3: 4089872-4093057 (X66401) Tapasin chr6: 33271410-33282164 (NM_172208) RFX5 chr1: 151313116-151319769 (NM_001025603) CIITA chr16: 10971055-11002744 (NM_000246) TAP1 chr6: 32812986-32821748 (NM_000593) TAP2 chr6: 32793187-32806547 (NM_000544) TAPBP chr6: 33267472-33282164 DMD chrX: 31137345-33229673 (NM_004006) RFX5 chr1: 151313116-151319769 (NM_000449) B. napus FAD3 See PCT publication JN992612 WO2014/039684 B. napus FAD2 See PCT publication JN992609 WO2014/039692 Soybean FAD2 See US20140090116 Zea mays ZP15 See U.S. Pat.", "No.", "8,329,986 GBWI-61522 (MaizeCyc) B-ketoacyl ACP synthase See U.S. Pat.", "No.", "8,592,645 II (KASII) Tomato MDH See US 20130326725 AY725474 B. napus EPSPS paralogs See U.S. Pat.", "No.", "8,399,218 C + D Paralog D See U.S. Pat.", "No.", "8,399,218 Paralog A + B See U.S. Pat.", "No.", "8,399,218 PPP1R12C (AAVS1) chr19: 55602840-55624858 (NM_017607) GR 5: 142646254-142783254 (NM_000176) IL2RG chrX: 70327254-70331481 (NM_000206) SFTPB chr2: 85884440-85895374 (NM_198843) Single-guide RNAs are then introduced into cells along with polynucleotides encoding one or more functional domains, and optionally donor sequences, for modification of the target gene.", "All patents, patent applications and publications mentioned herein are hereby incorporated by reference in their entirety.", "Although disclosure has been provided in some detail by way of illustration and example for the purposes of clarity of understanding, it will be apparent to those skilled in the art that various changes and modifications can be practiced without departing from the spirit or scope of the disclosure.", "Accordingly, the foregoing descriptions and examples should not be construed as limiting." ] ]
Patent_15872644
[ [ "OPACITY MODIFYING AGENTS FOR EDIBLE PRODUCTS", "An opacity modifying agent in particulate form comprising a starch, a dextrin, an optional film former, and an optional binder is disclosed herein.", "Also provided is an opacity modifying suspension comprising the opacity modifying agent and a liquid.", "The opacity modifying agent or suspension can be added to edible products to provide increased opacity.", "Methods of producing the opacity modifying agent are also disclosed." ], [ "1.An opacity modifying agent in particulate form comprising a starch, a dextrin, a film former, and a binder, wherein the agent comprises the starch in an amount from about 75% to about 90% by weight of the agent, wherein the agent comprises the dextrin in an amount from about 2.5% to about 10% by weight of the agent, and wherein the agent comprises the film former in an amount from about 0.1% to about 15% by weight of the agent.", "2.The agent of claim 1, wherein the starch is selected from the group consisting of unmodified corn starch, modified corn starch, unmodified tapioca starch, modified tapioca starch, unmodified potato starch, modified potato starch, unmodified rice starch, modified rice starch, unmodified wheat starch, modified wheat starch, alkaline treated starch, acid treated starch, bleached starch, roasted starch, hydroxypropyl starch, oxidized starch, and combinations thereof.", "3.The agent of claim 1, wherein the dextrin is selected from the group consisting of branched dextrin, unbranched dextrin, maltodextrin, amylodextrin, corn dextrin and combinations thereof.", "4.The agent of claim 1, comprising film former in an amount of at least about 0.1% and at most about 7% by weight of the agent.", "5.The agent of claim 1, wherein the film former is selected from the group consisting of agar, alginate, carrageenan, cassia, cellulose, caboxymethyl cellulose, gellan gum, guar gum, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, konjac, locust bean, methylcellulose, microcrystalline cellulose, pectin, xanthan gum, karaya gum, tragacanth, gum arabic, zein and combinations thereof.", "6.The agent of claim 1, comprising binder in an amount of less than about 25% by weight of the agent.", "7.The agent of claim 1, wherein the binder is selected from the group consisting of sucrose, molasses, calcium stearate, glycerin, propylene glycol, magnesium sulfate, mineral oil, oleic acid, alginate, calcium stearoyl lactylate, cholic acid, gelatin, hydroxylated lecithin, lecithin, partially hydrolyzed oil, polyglycerol polyricinoleate, sorbitan monostearate, stearate, polysorbate 80, polysorbate, quillaia, sorbitan monolaurate, wax and combinations thereof.", "8.The agent of claim 1, wherein the agent has an L* value when dispersed in a first sugar syrup comprising two-parts sucrose and one-part water by weight that is at least about 1% less than an L* value as measured in transmission mode or 1% greater than an L* value as measured in reflectance mode of a corresponding sugar syrup comprising a corresponding starch in an amount by weight equal to the amount by weight of the agent.", "9.The agent of claim 1, wherein the agent has a degrees Brix value when dispersed in a first sugar syrup comprising two-parts sucrose and one-part water by weight that is at least about 1% greater than a degrees Brix value of a corresponding sugar syrup comprising a corresponding starch in an amount by weight equal to the amount by weight of the agent.", "10.The agent of claim 1, wherein the agent is substantially free of titanium dioxide, calcium carbonate, or a combination thereof." ], [ "<SOH> BACKGROUND <EOH>Opacity modifying agents are an effective means of preventing, light penetration in food products.", "Colorants such as titanium dioxide and calcium carbonate have been used as opacity modifying agents.", "However, with interest in all natural food products increasing, there remains a need for effective opacity modifying agents that do not contain these components." ], [ "<SOH> SUMMARY <EOH>In an aspect, an opacity modifying agent is provided.", "This disclosure provides opacity modifying agents in particulate form comprising a starch, a dextrin, an optional film former, an optional binder and optional processing aids.", "This disclosure also provides methods for making an opacity modifying agent in particulate form, the method comprising combining a starch, a dextrin, an optional film former, an optional binder, and an optional processing aid to form the opacity modifying agent.", "This disclosure also provides methods for making an opacity modifying agent in particulate form, the method comprising combining a starch, a dextrin, an optional film former, an optional binder, an optional processing aid and a spray dry fluid to form a spray dry composition, and spray drying the spray dry composition to form the opacity modifying agent.", "This disclosure provides opacity modifying agents comprising starch in an amount from about 25% to about 99.99% by weight of the agent, starch in an amount from about 60% to about 95% by weight of the agent, or starch in an amount from about 75% to about 90% by weight of the agent.", "This disclosure provides opacity modifying agents comprising dextrin in an amount from about 0.1% to about 25% by weight of the agent, dextrin in an amount from about 0.5% to about 15% by weight of the agent, or dextrin in an amount from about 2.5% to about 10% by weight of the agent.", "This disclosure provides opacity modifying agents comprising film former in an amount of less than about 25% by weight of the agent, film former in an amount of less than about 15% by weight of the agent, or film former in an amount from about 0.25% to about 10% by weight of the agent.", "This disclosure provides opacity modifying agents comprising binder in an amount of less than about 25% by weight of the agent, binder in an amount of less than about 5% by weight of the agent, or binder in an amount from about 0.25% to about 2.5% by weight of the agent.", "This disclosure provides opacity modifying agents comprising processing aid in an amount of less than about 25% by weight of the agent, processing aid in an amount of less than about 10% by weight of the agent, or processing aid in an amount, from about 0.25% to about 5% by weight of the agent.", "This disclosure provides opacity modifying agents wherein the starch is selected, for example, from the group consisting of unmodified corn starch, modified corn starch, unmodified tapioca starch, modified tapioca starch, unmodified potato starch, modified potato starch, unmodified rice starch, modified rice starch, unmodified wheat starch, modified wheat starch, alkaline treated starch, acid treated starch, bleached starch, roasted starch, hydroxypropyl starch, oxidized starch, and combinations thereof.", "This disclosure provides opacity modifying agents wherein the dextrin is selected, for example, from the group consisting of branched dextrin, unbranched dextrin, maltodextrin, amylodextrin, corn dextrin and combinations thereof.", "This disclosure provides opacity modifying agents wherein the film former is selected, for example, from the group consisting of agar, alginate, carrageenan, cassia, cellulose, caboxymethyl cellulose, gellan gum, guar gum, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, konjac, locust bean, methylcellulose, microcrystalline cellulose, pectin, xanthan gum, karaya gum, tragacanth, gum arabic, zein and combinations thereof.", "This disclosure provides opacity modifying agents wherein the binder is selected, for example, from the group consisting of sucrose, molasses, calcium stearate, glycerin, propylene glycol, magnesium sulfate, mineral oil, oleic acid, alginate, calcium stearoyl lactylate, cholic acid, gelatin, hydroxylated lecithin, lecithin, partially hydrolyzed oil, polyglycerol polyricinoleate, sorbitan monostearate, stearate, polysorbate 80, polysorbate, quillaia, sorbitan monolaurate and combinations thereof.", "This disclosure provides opacity modifying agents wherein the processing aid is selected, for example, from the group consisting of methyl paraben, ethyl paraben, propyl paraben, sodium benzoate, H 3 PO 4 , ascorbic acid, citric acid, potassium sorbate, benzoic acid, ethylenediaminetetraacetic acid, glycerin, propylene glycol, tetrasodium pyrophosphate, NaCO 3 , CaCO 3 , NaH 2 PO 4 , calcium diacetate, calcium hexametaphosphate, CaHPO 4 , K 2 HPO 4 , Na 2 HPO 4 , sodium gluconate, sodium hexametaphosphate, sodium metaphosphate, NaH 2 PO 4 , Na 4 P 2 O 7 , coconut oil ester, polyvinyl acetate), KMnO 4 , NaOH, KOH, HCl, sorbitol, sucrose ester, wax and combinations thereof.", "This disclosure provides opacity modifying agents, wherein the agent has an L* value when dispersed in a first sugar syrup comprising two-parts sucrose and one-part water by weight that is at least about 1% less than an L* value as measured in transmission mode or 1% greater than an L* value as measured in reflectance mode of a corresponding sugar syrup comprising a corresponding starch in an amount by weight equal to the amount by weight of the agent or the amount by weight of the starch in the agent, the corresponding starch not provided with a dextrin, a film former or a binder.", "A corresponding sugar syrup is a sugar syrup comprising sucrose and water in a ratio equal to the first sugar syrup.", "A corresponding starch is a starch of the same type as the starch in the opacity modifying agent.", "This disclosure also provides opacity modifying agents, wherein a substance coated by a coating containing the agent has an L* value that is at least about 1% greater than an L* value as measured in reflectance mode of the substance coated by a coating containing a corresponding starch in an amount by weight equal to the amount by weight of the agent, or the amount by weight of the starch in the agent but not containing a dextrin, a film former or a binder.", "This disclosure also provides opacity modifying agents, wherein the agent has a degrees Brix value when dispersed in a first sugar syrup comprising two-parts sucrose and one-part water by weight that is at least about 1% greater than a degrees.", "Brix value of a corresponding sugar syrup comprising a corresponding starch in an amount by weight equal to the amount by weight of the agent.", "This disclosure also provides opacity modifying suspensions comprising an opacity modifying agent and a liquid.", "This disclosure provides opacity modifying suspensions comprising the opacity modifying agent in an amount from about 0.1% to about 50% by weight of the suspension.", "This disclosure provides opacity modifying suspensions comprising the liquid in an amount from about 50% to about 99.9% by weight of the suspension.", "This disclosure provides opacity modifying suspensions wherein the liquid is selected from the group consisting of water, ethanol, isopropanol, propylene glycol, oil and combinations thereof.", "This disclosure also provides opacity modifying agents which are in particulate form, such as dry powder or granules.", "This disclosure also provides methods of modifying the opacity of an edible substance, the method comprising contacting the edible substance with an opacity modifying agent or opacity modifying suspension according to this invention.", "This disclosure provides methods wherein the opacity of the edible substance increased by at least about 10%.", "Other aspects and embodiments of the disclosure will become apparent to one of skill in the art in light of the following description." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "14/441,333, filed May 7, 2015, which is a U.S. national stage filing under 35 U.S.C.", "371 of International Application No.", "PCT/US2013/069284, filed Nov. 8, 2013, which claims priority to U.S.", "Provisional Patent Application No.", "61/724,791, filed Nov. 9, 2012, each of which is incorporated herein by reference in its entirety.", "BACKGROUND Opacity modifying agents are an effective means of preventing, light penetration in food products.", "Colorants such as titanium dioxide and calcium carbonate have been used as opacity modifying agents.", "However, with interest in all natural food products increasing, there remains a need for effective opacity modifying agents that do not contain these components.", "SUMMARY In an aspect, an opacity modifying agent is provided.", "This disclosure provides opacity modifying agents in particulate form comprising a starch, a dextrin, an optional film former, an optional binder and optional processing aids.", "This disclosure also provides methods for making an opacity modifying agent in particulate form, the method comprising combining a starch, a dextrin, an optional film former, an optional binder, and an optional processing aid to form the opacity modifying agent.", "This disclosure also provides methods for making an opacity modifying agent in particulate form, the method comprising combining a starch, a dextrin, an optional film former, an optional binder, an optional processing aid and a spray dry fluid to form a spray dry composition, and spray drying the spray dry composition to form the opacity modifying agent.", "This disclosure provides opacity modifying agents comprising starch in an amount from about 25% to about 99.99% by weight of the agent, starch in an amount from about 60% to about 95% by weight of the agent, or starch in an amount from about 75% to about 90% by weight of the agent.", "This disclosure provides opacity modifying agents comprising dextrin in an amount from about 0.1% to about 25% by weight of the agent, dextrin in an amount from about 0.5% to about 15% by weight of the agent, or dextrin in an amount from about 2.5% to about 10% by weight of the agent.", "This disclosure provides opacity modifying agents comprising film former in an amount of less than about 25% by weight of the agent, film former in an amount of less than about 15% by weight of the agent, or film former in an amount from about 0.25% to about 10% by weight of the agent.", "This disclosure provides opacity modifying agents comprising binder in an amount of less than about 25% by weight of the agent, binder in an amount of less than about 5% by weight of the agent, or binder in an amount from about 0.25% to about 2.5% by weight of the agent.", "This disclosure provides opacity modifying agents comprising processing aid in an amount of less than about 25% by weight of the agent, processing aid in an amount of less than about 10% by weight of the agent, or processing aid in an amount, from about 0.25% to about 5% by weight of the agent.", "This disclosure provides opacity modifying agents wherein the starch is selected, for example, from the group consisting of unmodified corn starch, modified corn starch, unmodified tapioca starch, modified tapioca starch, unmodified potato starch, modified potato starch, unmodified rice starch, modified rice starch, unmodified wheat starch, modified wheat starch, alkaline treated starch, acid treated starch, bleached starch, roasted starch, hydroxypropyl starch, oxidized starch, and combinations thereof.", "This disclosure provides opacity modifying agents wherein the dextrin is selected, for example, from the group consisting of branched dextrin, unbranched dextrin, maltodextrin, amylodextrin, corn dextrin and combinations thereof.", "This disclosure provides opacity modifying agents wherein the film former is selected, for example, from the group consisting of agar, alginate, carrageenan, cassia, cellulose, caboxymethyl cellulose, gellan gum, guar gum, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, konjac, locust bean, methylcellulose, microcrystalline cellulose, pectin, xanthan gum, karaya gum, tragacanth, gum arabic, zein and combinations thereof.", "This disclosure provides opacity modifying agents wherein the binder is selected, for example, from the group consisting of sucrose, molasses, calcium stearate, glycerin, propylene glycol, magnesium sulfate, mineral oil, oleic acid, alginate, calcium stearoyl lactylate, cholic acid, gelatin, hydroxylated lecithin, lecithin, partially hydrolyzed oil, polyglycerol polyricinoleate, sorbitan monostearate, stearate, polysorbate 80, polysorbate, quillaia, sorbitan monolaurate and combinations thereof.", "This disclosure provides opacity modifying agents wherein the processing aid is selected, for example, from the group consisting of methyl paraben, ethyl paraben, propyl paraben, sodium benzoate, H3PO4, ascorbic acid, citric acid, potassium sorbate, benzoic acid, ethylenediaminetetraacetic acid, glycerin, propylene glycol, tetrasodium pyrophosphate, NaCO3, CaCO3, NaH2PO4, calcium diacetate, calcium hexametaphosphate, CaHPO4, K2HPO4, Na2HPO4, sodium gluconate, sodium hexametaphosphate, sodium metaphosphate, NaH2PO4, Na4P2O7, coconut oil ester, polyvinyl acetate), KMnO4, NaOH, KOH, HCl, sorbitol, sucrose ester, wax and combinations thereof.", "This disclosure provides opacity modifying agents, wherein the agent has an L* value when dispersed in a first sugar syrup comprising two-parts sucrose and one-part water by weight that is at least about 1% less than an L* value as measured in transmission mode or 1% greater than an L* value as measured in reflectance mode of a corresponding sugar syrup comprising a corresponding starch in an amount by weight equal to the amount by weight of the agent or the amount by weight of the starch in the agent, the corresponding starch not provided with a dextrin, a film former or a binder.", "A corresponding sugar syrup is a sugar syrup comprising sucrose and water in a ratio equal to the first sugar syrup.", "A corresponding starch is a starch of the same type as the starch in the opacity modifying agent.", "This disclosure also provides opacity modifying agents, wherein a substance coated by a coating containing the agent has an L* value that is at least about 1% greater than an L* value as measured in reflectance mode of the substance coated by a coating containing a corresponding starch in an amount by weight equal to the amount by weight of the agent, or the amount by weight of the starch in the agent but not containing a dextrin, a film former or a binder.", "This disclosure also provides opacity modifying agents, wherein the agent has a degrees Brix value when dispersed in a first sugar syrup comprising two-parts sucrose and one-part water by weight that is at least about 1% greater than a degrees.", "Brix value of a corresponding sugar syrup comprising a corresponding starch in an amount by weight equal to the amount by weight of the agent.", "This disclosure also provides opacity modifying suspensions comprising an opacity modifying agent and a liquid.", "This disclosure provides opacity modifying suspensions comprising the opacity modifying agent in an amount from about 0.1% to about 50% by weight of the suspension.", "This disclosure provides opacity modifying suspensions comprising the liquid in an amount from about 50% to about 99.9% by weight of the suspension.", "This disclosure provides opacity modifying suspensions wherein the liquid is selected from the group consisting of water, ethanol, isopropanol, propylene glycol, oil and combinations thereof.", "This disclosure also provides opacity modifying agents which are in particulate form, such as dry powder or granules.", "This disclosure also provides methods of modifying the opacity of an edible substance, the method comprising contacting the edible substance with an opacity modifying agent or opacity modifying suspension according to this invention.", "This disclosure provides methods wherein the opacity of the edible substance increased by at least about 10%.", "Other aspects and embodiments of the disclosure will become apparent to one of skill in the art in light of the following description.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a photograph showing dragees coated with coatings containing varying amounts of opacity modified agents as described in Example 7.FIG.", "2 is a photograph showing the comparative coating strength of a coating containing opacity modifying agents versus a coating containing Fusion White as described in Example 11.DETAILED DESCRIPTION The present disclosure is not limited to the specific details of construction, arrangement of components, or method steps set forth herein.", "The compositions and methods disclosed herein are capable of being made, practiced, used, carried out and/or formed in various ways that will be apparent to one of skill in the art in light of the disclosure that follows.", "The phraseology and terminology used herein is for the purpose of description only and should not be regarded as limiting to the scope of the claims.", "Ordinal indicators, such as first, second, and third, as used in the description and the claims to refer to various structures or method steps, are not meant to be construed to indicate any specific structures or steps, or any particular order or configuration to such structures or steps.", "All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context.", "The use of any and all examples, or exemplary language (e.g., “such as”) provided herein, is intended merely to facilitate the disclosure and does not imply any limitation on the scope of the disclosure unless otherwise claimed.", "No language in the specification, and no structures shown in the drawings, should be construed as indicating that any non-claimed element is essential to the practice of the disclosed subject matter.", "The use herein of the terms “including,” “comprising,” or “having,” and variations thereof, is meant to encompass the elements listed thereafter and equivalents thereof, as well as additional elements.", "Embodiments recited as “including,” “comprising,” or “having” certain elements are also contemplated as “consisting essentially of” and “consisting of” those certain elements.", "Recitation of ranges of values herein are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein, and each separate value is incorporated into the specification as if it were individually recited herein.", "For example, if a concentration range is stated as 1% to 50%, it is intended that values such as 2% to 40%, 10% to 30%, or 1% to 3%, etc., are expressly enumerated in this specification.", "These are only examples of what is specifically intended, and all possible combinations of numerical values between and including the lowest value and the highest value enumerated are to be considered to be expressly stated in this disclosure.", "Use of the word “about” to describe a particular recited amount or range of amounts is meant to indicate that values very near to the recited amount are included in that amount, such as values that could or naturally would be accounted for due to manufacturing tolerances, instrument and human error in forming measurements, and the like.", "All percentages referring to amounts are by weight unless indicated otherwise.", "No admission is made that any reference, including any non-patent or patent document cited in this specification, constitutes prior art.", "In particular, it will be understood that, unless otherwise stated, reference to any document herein does not constitute an admission that any of these documents forms part of the common general knowledge in the art in the United States or in any other country.", "Any discussion of the references states what their authors assert, and the applicant reserves the right to challenge the accuracy and pertinence of any of the documents cited herein.", "All references cited herein are fully incorporated by reference, unless explicitly indicated otherwise.", "The present disclosure shall control in the event there are any disparities between any definitions and/or description found in the cited references.", "In an aspect, the disclosure provides affordable and easy-to-use opacity modifying agents.", "In an aspect, the disclosure provides opacity modifying suspensions comprising opacity modifying agents.", "In an aspect, the disclosure provides methods for making opacity modifying agents.", "In an aspect, the disclosure provides methods for using opacity modifying agents.", "A starch may include any carbohydrate composed of amylose and amylopectin that is capable of functioning as part of an opacity modifying agent according to this invention.", "Examples of starches include, but are not limited to, unmodified corn starch, modified corn starch, unmodified tapioca starch, modified tapioca starch, unmodified potato starch, modified potato starch, unmodified rice starch, modified rice starch, unmodified wheat starch, modified wheat starch, alkaline treated starch, acid treated starch, bleached starch, roasted starch, hydroxypropyl starch, oxidized starch, and the like.", "A variety of examples of commercially available starches exist and may include, for example, PenPure® 30 rice starch (available from Penford Food Ingredients, Centennial, Colo.), EmCap® Starches (available from Cargill, Minnetonka, Minn.), and Ultra-Sperse® Corn Starches (available from Ingredion, Westchester, Ill.).", "A dextrin may include any one, or the mixture, of water-soluble, intermediate polysaccharides formed during the hydrolysis of starch to sugar that is capable of functioning as part of an opacity modifying agent according to this invention.", "Examples of dextrins include, but are not limited to, branched dextrin, unbranched dextrin, maltodextrin, amylodextrin, corn dextrin, and the like.", "A variety of examples of commercially available dextrins exist and may include, for example, Maltrin® M040 Maltodextrin (available from Grain Processing Corp, Muscatine, Iowa) and AVEBE MD 20 (available from Avebe, Veendam, Netherlands).", "A film former may contribute to the smooth suspension and coating properties of the compositions disclosed herein.", "Examples of film formers include, but are not limited to, agar, alginate, carrageenan, cassia, cellulose, caboxymethyl cellulose, gellan gum, guar gum, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, konjac, locust bean, methylcellulose, microcrystalline cellulose, pectin, xanthan gum, karaya gum, tragacanth, gum arabic, zein (i.e.", "corn zein), and the like.", "A variety of examples of commercially available film formers exist and may include, for example, Spectracel HPMC compositions (available from Sensient Technologies, Milwaukee, Wis.).", "A binder may contribute to the physical stability of the compositions disclosed herein.", "Examples of binders include, but are not limited to, sucrose, molasses, calcium stearate, glycerin, propylene glycol, magnesium sulfate, mineral oil, oleic acid, alginate, calcium stearoyl lactylate, cholic acid, gelatin, hydroxylated lecithin, lecithin, partially hydrolyzed oil, polyglycerol polyricinoleate, sorbitan monostearate, stearate, polysothate 80, polysorbate, quillaia, sorbitan monolaurate, wax, and the like.", "A variety of examples of commercially available binders exist and may include, for example Glycerine (available from Univar, Kent, Wash.) and Q-Naturale™ 200 (available from Ingredion, Westchester, Ill.).", "Examples of waxes may include, but are not limited to, paraffin wax, candelilla wax, beeswax, carnauba wax, and combinations thereof.", "Processing aids may provide improved properties to the opacity modifying agents and food products contacted by said agents, such as acting as preservatives, as carrier or flow agents, or otherwise improving the physical properties of the opacity modifying agents.", "Examples of processing aids include, but are not limited to, preservatives, talc, calcium carbonate, clay, ammonium chloride, silica, sodium sulfate, calcium phosphate, propylene glycol dicaprylate/dicaprate, medium chain triglycerides (e.g., fractionated coconut oil), glyceryl monostearate, propylene glycol, polypropylene glycol, polyethylene glycol, triacetin, glycerin, dibutyl sebacate, triglycerides, acetylated monoglycerides, glycerol monstearates, glycerin monostearate, oleic acid, stearic acid, sorbitol, tributyl citrate, acetyltributyl citrate, dibutyl phthalate, triethyl citrate, triethanolamine, aqueous emulsions of glyceryl monostearate and triethyl citrate and combinations thereof.", "Examples of preservatives may include, but are not limited to, methyl paraben, ethyl paraben, propyl paraben, sodium benzoate, H3PO4, ascorbic acid, citric acid, potassium sorbate, benzoic acid, ethylenediaminetetraacetic acid (EDTA), glycerin, propylene glycol and combinations thereof.", "Plasticizing agents may enhance the characteristics of solids containing the opacity modifying agent of the present invention, such as adhesion, flexibility, permeability, and the like.", "In embodiments, plasticizing agents may include medium chain triglycerides, fatty acids, fatty acid derivatives, and combinations thereof.", "In some embodiments, examples of plasticizing agents may include, but are not limited to, propylene glycol dicaprylate/dicaprate, medium chain triglycerides (e.g., fractionated coconut oil), glyceryl monostearate, propylene glycol, polypropylene glycol, polyethylene glycol, triacetin, glycerin, dibutyl sebacate, triglycerides, acetylated monoglycerides, glycerol monstearates, glycerin monostearate, oleic acid, stearic acid, sorbitol, tributyl citrate, acetyltributyl citrate, dibutyl phthalate, triethyl citrate, triethanolamine, aqueous emulsions of glyceryl monostearate and triethyl citrate, and combinations thereof.", "Commercially available examples of propylene glycol dicaprylate/dicaprate include, for example, Miglyol® 840 (available from Sasol GmbH) and Neobee® M-20 (available from Stepan Co.).", "Examples of colorants which may be used include dyes, lakes, and pigments.", "Alternatively, the opacity modifying agent or product formed from the opacity modifying agent may be substantially free of one or more dyes, lakes and pigments.", "In certain embodiments, the opacity modifying agent may contain less than about 0.01% or less than about 0.1% by weight of one or more of the dyes, lakes or pigments disclosed herein.", "Dyes lakes and pigments include, but are not limited to, iron oxides, titanium dioxide, calcium carbonate, clay, talc, barium sulfate, white carbon, chromium oxide, zinc oxide, zinc sulfide, zinc powder, metal powder pigments, iron black, yellow iron oxide, red iron oxide, chrome yellow, carbon black, molybdate orange, Prussian Blue, ultramarine blue, cadmium type pigments, fluorescent pigments, phthalocyanine pigments, condensed polycyclic pigments, composite oxide pigments, graphite, mica (such as, muscovite, phlogopite, synthetic mica, and fluorine tetra silicon mica), dyes such as, for example, soluble azo dyes, insoluble azo dyes, condensed azo dyes, FD&C Lakes, Carmine Lake, FD&C Blue no.", "1, FD&C Red no.", "3, FD&C Red no.", "40, FD&C Yellow no.", "5, FD&C Yellow no.", "6, FD&C Green no.", "3, alumina, annatto extract, canthaxanthin, caramel, β-carotene, carmine, dihydroxyacetone, tumeric oleoresin, cochineal extract, gardenia yellow, gardenia blue, beet powder, grape skin extract, riboflavin, purple sweet potato, red sweet potato, chlorophyll-containing extracts, pearlescent pigments, SensiPearl™ Blue, Silver, and.", "Bright Silver (available from Sensient Colors, Inc), natural colorants, and the like.", "Other examples of colorants are found in 21 C.F.R.", "§§ 73 and 74, which are hereby fully incorporated by reference.", "Surfactants may function as wetting agents, lowering surface tension and interfacial tension.", "Examples of surfactants include, but are not limited to, polysorbates (polyethoxylated sorbitan fatty acid derivatives) such as, for example, polysorbate 80; polyglyceryl 10 laurate; lecithins; mono- and di-glycerides; propylene glycol; sodium lauryl sulfate; acetylated monoglycerides; additives of propyl gallate and citric acid and stabilizers therein; alcohol; alkali metal and ammonium salts of ethylene diamine tetracetic acid, nitrilo triacetic acid, citric acid, phosphoric acid, tartaric acid, glycolic acid, malic acid, lactic acid, acetic acid, and benzoic acid; and combinations thereof.", "Buffering agents may impart anionic/cationic ratios of minerals of sodium, potassium, magnesium, and/or calcium.", "Examples of buffering agents include, but are not limited to, citric acid and sodium citrate.", "Suitable buffering agents can be selected based on the particular formulation and/or application.", "Examples of liquids may include, but are not limited to, water, ethanol, isopropanol, propylene glycol, glycerine, oil and combinations thereof.", "Examples of suitable oils may include, but are not limited to, palm oil, vegetable oil, soybean oil, cottonseed oil, coconut oil and combinations thereof.", "The opacity modifying agent can include starch in an amount of at least about 25%, at least about 30%, at least about 35%, at least about 40%, at least about 45%, at least about 50%, at least about 55%, at least about 60%, at least about 65%, at least about 70%, at least about 75%, at least about 76%, at least about 77%, at least about 78%, at least about 79%, at least about 80%, at least about 81%, at least about 82%, at least about 83%, at least about 84%, at least about 85%, at least about 86%, at least about 87%, at least about 88%, at least about 89%, or at least about 90% by weight of the agent.", "The opacity modifying agent can include starch in an amount of at most about 99.99%, at most about 99%, at most about 95%, at most about 90%, at most about 89%, at most about 88%, at most about 87%, at most about 86%, at most about 85%, at most about 84%, at most about 83%, at most about 82%, at most about 81%, at most about 80%, at most about 79%, at most about 78%, at most about 77%, at most about 76%, at most about 75%, at most about 70%, at most about 65%, at most about 60%, at most about 55%, at most about 50%, at most about 45%, at most about 40%, at most about 35%, or at most about 30% by weight of the agent.", "This includes, for example, starch in an amount from about 25% to about 99.99%, about 60% to about 95%, and about 75% to about 90% by weight of the agent.", "In some embodiments, the starch can include, for example, an unmodified rice starch.", "The starch may include protein in an amount of at most about 1%, at most about 0.9%, at most about 0.8%, at most about 0.7%, at most about 0.6%, at most about 0.5%, at most about 0.4%, at most about 0.3%, at most about 0.25%, at most about 0.2%, at most about 0.15%, at most about 0.1%, at most about 0.05%, or at most about 0.01% by weight of the starch.", "The starch may include fat in an amount of at most about 1%, at most about 0.9%, at most about 0.8%, at most about 0.7%, at most about 0.6%, at most about 0.5%, at most about 0.4%, at most about 0.3%, at most about 0.25%, at most about 0.2%, at most about 0.15%, at most about 0.1%, at most about 0.05%, or at most about 0.01% by weight of the starch.", "The starch may include H2O2 in an amount of at most about 0.5%, at most about 0.4%, at most about 0.3%, at most about 0.25%, at most about 0.2%, at most about 0.15%, at most about 0.1%, at most about 0.05%, or at most about 0.01% by weight of the starch.", "The starch may have an average particle size of at most about 1 mm, at most about 0.9 mm, at most about 0.8 mm, at most about 0.7 mm, at most about 0.6 mm, at most about 0.5 mm, at most about 0.45 mm, at most about 0.4 mm, at most about 0.35 mm, at most about 0.3 mm, at most about 0.25 mm, at most about 0.24 mm, at most about 0.23 mm, at most about 0.22 mm, at most about 0.21 mm, at most about 0.20 mm, at most about 0.19 mm, at most about 0.18 mm, at most about 0.17 mm, at most about 0.16 mm, at most about 0,15 mm, at most about 0.14 mm, at most about 0.13 mm, at most about 0.12 mm, at most about 0.11 mm, or at most about 0.10 mm.", "The starch may have an average granule size of at least, about 0.01 μm, at least about 0.05 μm, at least about 0.1 μm, at least about 0.5 μm, at least about 1 μm, at least about 1.5 μm, at least about 2 μm, at least about 2.5 μm, at least about 3 μm, at least about 3.5 μm, at least about 4 μm, at least about 4.5 μm, at least about 5 μm, at least about 5.5 μm, at least about 6 μm, at least about 6.5 μm, at least about 7 μm, at least about 7.5 μm, at least about 8 μm, at least about 8.5 μm, at least about 9 μm, or at least about 9.5 μm.", "The starch may have a granule size of at most about 100 μm, at most about 50 μm, at most about 25 μm, at most about 10 μm, at most about 9.5 μm, at most about 9 μm, at most about 8.5 μm, at most about 8 μm, at most about 7.5 μm, at most about 7 μm, at most about 6.5 pm, at most about 6 μm, at most about 5.5 μm, at most about 5 μm, at most about 4.5 μm, at most about 4 μm, at most about 3.5 μm, at most about 3 μm, at most about 2.5 μm, at most about 2 μm, at most about 1.5 μm, or at most about 1 μm.", "This includes, for example, a granule size of from about 2 μm to about 8 μm.", "The opacity modifying agent can include dextrin in an amount of at least 0%, at least about 0.1%, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1.0%, at least about 1.5%, at least about 2.0%, at least about 2.5%, at least about 3.0%, at least about 3.5%, at least about 4.0%, at least about 4.5%, at least about 5.0%, at least about 6.0%, at least about 7.0%, at least about 8.0%, at least about 9.0%, at least about 10.0%, at least about 11.0%, at least about 12.0%, at least about 13.0%, at least about 14.0%, at least about 15.0%, at least about 16.0%, at least about 17.0%, at least about 18.0%, at least about 19.0%, at least about 20.0%, at least about 21.0%, at least about 22.0%, at least about 23.0%, or at least about 24.0% by weight of the agent.", "The opacity modifying agent can include dextrin in an amount of at most about 25.0%, at most about 24.0%, at most about 23.0%, at most about 22.0%, at most about 21.0%, at most about 20.0%, at most about 19.0%, at most about 18.0%, at most about 17.0%, at most about 16.0%, at most about 15.0%, at most about 14.0%, at most about 13.0%, at most about 12.0%, at most about 11.0%, at most about 10.0%, at most about 9.0%, at most about 8.0%, at most about 7.0%, at most about 6.0%, or at most about 5.0% by weight of the agent.", "This includes, for example, dextrin in an amount from 0.1% to about 25.0%, 0.5% to about 15%, and about 2.5% to about 10% by weight of the agent.", "In some embodiments, the dextrin can include, for example, maltodextrin.", "The opacity modifying agent can include film former in an amount of at least 0%, at least about 0.1%, at least about 0,2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1.0%, at least about 1.25%, at least about 1.5%, at least about 1.75%, at least about 2.0%, at least about 2.25%, at least about 2.5%, at least about 3%, at least about 4.0%, at least about 4.5%, at least about 5.0%, at least about 6.0%, at least about 7.0%, at least about 8.0%, at least about 9.0%, at least about 10.0%, at least about 11.0%, at least about 12.0%, at least about 13.0%, at least about 14.0%, at least about 15.0%, at least about 16.0%, at least about 17,0%, at least about 18.0%, at least about 19.0%, at least about 20.0%, at least about 21.0%, at least about 22.0%, at least about 23.0%, or at least about 24.0% by weight of the agent.", "The opacity modifying agent can include film former in an amount of at most about 25.0%, at most about 24.0%, at most about 23.0%, at most about 22.0%, at most about 21.0%, at most about 20.0%, at most about 19.0%, at most about 18.0%, at most about 17.0%, at most about 16.0%, at most about 15.0%, at most about 14.0%, at most about 13.0%, at most about 12.0%, at most about 11.0%, at most about 10.0%, at most about 9.0%, at most about 8.0%, at most about 7.0%, at most about 6.0%, or at most about 5.0% by weight of the agent, at most about 4.0%, at most about 3.0%, at most about 2.5%, at most about 2.25%, at most about 2.0%, at most about 1.75%, at most about 1.5%, at most about 1.25%, at most about 1.0%, at most about 0.75%, or at most about 0.5% by weight of the agent.", "This includes, for example, film former in an amount from 0.1% to about 25%, 0.5% to about 15%, and about 2.5% to about 10.0% by weight of the agent.", "In some embodiments, the film former can include, for example, hydroxypropyl methyl cellulose.", "The opacity modifying agent can include binder in an amount of at least 0%, at least about 0.25%, at least about 0.5%, at least about 0.75%, at least about 1.0%, at least about 1.25%, at least about 1.5%, at least about 1.75%, at least about 2.0%, at least about 2.25%, at least about 2.5%, at least about 3%, at least about 4%, at least about 5%, at least about 10%, at least about 15%, or at least about 20% by weight of the agent.", "The opacity modifying agent can include binder in an amount of at most about 25%, at most about 20%, at most about 15%, at most about 10%, at most about 5%, at most about 4%, at most about 3%, at most about 2.5%, at most about 2.25%, at most about 2.0%, at most about 1.75%, at most about 1.5%, at most about 1.25%, at most about 1.0%, at most about 0.75%, or at most about 0.5% by weight of the agent.", "This includes, for example, binder in an amount from 0% to about 25%, 0% to about 5%, and about 0.25% to about 2.5% by weight of the agent.", "In some embodiments, the binder can include, for example, sunflower lecithin, polysorbate 80 or a combination thereof.", "In certain embodiments, the opacity modifying agent may include no titanium dioxide, no calcium carbonate, or no titanium dioxide and no calcium carbonate.", "In certain embodiments, the opacity modifying agent may be substantially free of one or both of titanium dioxide and calcium carbonate.", "In certain embodiments, the opacity modifying agent may contain less than about 0.01% or less than about 0.1% by weight of one or both of titanium dioxide and calcium carbonate.", "The opacity modifying agent may have an average particle size of at most about 10.0 mm, at most about 9.0 mm, at most about 8.0 mm, at most about 7.0 mm, at most about 6.0 mm, at most about 5.0 mm, at most about 4.0 mm, at most about 3.0 mm, at most about 2.0 mm, at most about 1.0 mm, at most about 0.9 mm, at most about 0.8 mm, at most about 0.7 mm, at most about 0.6 mm, at most about 0.5 mm, at most about 0.45 mm, at most about 0.4 mm, at most about 0.35 mm, at most about 0.3 mm, at most about 0.25 mm, at most about 0.24 mm, at most about 0.23 mm, at most about 0.22 mm, at most about 0.21 mm, at most about 0.20 mm, at most about 0.19 mm, at most about 0.18 mm, at most about 0.17 mm, at most about 0.16 mm, at most about 0.15 mm, at most about 0.14 mm, at most about 0.13 mm, at most about 0.12 mm, at most about 0.11 mm, or at most about 0.10 mm.", "In an aspect, the disclosure provides an opacity modifying suspension comprising an opacity modifying agent and a liquid.", "The opacity modifying suspension can include opacity modifying agent in an amount of at least about 0.1%, at least about 0.5%, at least about 1%, at least about 2%, at least about 3%, at least about 4%, at least about 5%, at least about 6%, at least about 7%, at least about 8%, at least about 9%, at least about 10%, at least about 11%, at least about 12%, at least about 13%, at least about 14%, at least about 15%, at least about 16%, at least about 17%, at least about 18%, at least about 19%, at least about 20%, at least about 21%, at least about 22%, at least about 23%, at least about 24%, at least about 25%, at least about 30%, at least about 35%, at least about 40%, or at least about 45% by weight of the suspension.", "The opacity modifying suspension can include opacity modifying agent in an amount of at most about 50%, at most about 45%, at most about 40%, at most about 35%, at most about 30%, at most about 25%, at most about 24%, at most about 23%, at most about 22%, at most about 21%, at most about 20%, at most about 19%, at most about 18%, at most about 17%, at most about 16%, at most about 15%, at most about 14%, at most about 13%, at most about 12%, at most about 11%, at most about 10%, at most about 9%, at most about 8%, at most about 7%, at most about 6%, at most about 5%, at most about 4%, at most about 3%, at most about 2%, or at most about 1% by weight of the suspension.", "This includes, for example, opacity modifying agent in an amount of from about 0.1% to about 50%, about 0.5% to about 25%, and about 5% to about 20% by weight of the suspension.", "The opacity modifying suspension can include liquid in an amount of at least about 50%, at least about 55%, at least about 60%, at least about 65%, at least about 70%, at least about 75%, at least about 76%, at least about 77%, at least about 78%, at least about 79%, at least about 80%, at least about 81%, at least about 82%, at least about 83%, at least about 84%, at least about 85%, at least about 86%, at least about 87%, at least about 88%, at least about 89%, at least about 90%, at least about 91%, at least about 92%, at least about 93%, at least about 94%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, or at least about 99% by weight of the suspension.", "The opacity modifying suspension can include liquid in an amount of at most about 99.9%, at most about 99%, at most about 98%, at most about 97%, at most about 96%, at most about 95%, at most about 94%, at most about 93%, at most about 92%, at most about 91%, at most about 90%, at most about 89%, at most about 88%, at most about 87%, at most about 86%, at most about 85%, at most about 84%, at most about 83%, at most about 82%, at most about 81%, at most about 80%, at most about 79%, at most about 78%, at most about 77%, at most about 76%, at most about 75%, at most about 70%, at most about 65%, at most about 60%, at most about 55%, at most about 50% by weight of the suspension.", "This includes, for example, liquid in an amount from about 50% to about 99.9%, about 75% to about 99.5%, and about 80% to about 95% by weight of the suspension.", "In some embodiments, the liquid can include, for example, water, ethanol, isopropanol, propylene glycol, glycerine, oil or a combination thereof.", "In an aspect, the disclosure provides a method of making an opacity modifying agent.", "In one embodiment, the method may comprise combining a starch, a dextrin, an optional film former, an optional binder, and an optional processing aid to form the opacity modifying agent, such as by dry blending.", "The dust which forms while forming the agent may be reduced compared with dust formed when processing the starch with no dextrin, no binder, no film former or a combination thereof.", "In another embodiment, the method may comprise combining a starch, a dextrin, an optional film former, an optional binder, an optional processing aid and a spray dry fluid to form a spray dry composition, and spray drying the spray dry composition to form the opacity modifying agent.", "In some embodiments, the spray dry fluid may comprise water or preservatives.", "In an aspect, the disclosure provides a method of modifying the opacity of an edible substance such as a food substance.", "In some embodiments, the method may comprise contacting the edible or food substance with the opacity modifying agent or a suspension comprising the opacity modifying agent of this invention.", "In one embodiment, the opacity modifying agent is mixed with sugar syrup to provide a sugar syrup with increased opacity.", "The opacity modifying agents may be used in edible products such as food, pharmaceutical or nutraceutical applications.", "The edible products may be intended for use in mammals, including, without, limitation, rodents, canines, felines, non-human primates, ungulates, and humans.", "The opacity modifying agents can be used in pharmaceutical or non-pharmaceutical dosage units.", "Suitable food products include, without limitation, cereal, panned goods, baked goods, extruded foods, pet treats, beverages, icings, syrups, gummies, hard candy, licorice, and the like.", "The opacity modifying agents may be coated onto the edible product, be dispersed throughout the edible product, or layered in the edible product.", "The opacity modifying agents may be used to modify the opacity of cosmetic products, personal care products, hair care products, paints, inks, plastics, leather and other surface treatments, and combinations thereof.", "Cosmetic products can include, but are not limited to, mascaras, pressed powder make-ups (e.g., eye shadows, cheek rouge and facial powders), liquid make-ups (e.g., eye shadows, foundations, cheek rouge, blushes, lip liners, eye liners and nail enamel), lipsticks, or combinations thereof.", "Personal care products can include, but are not limited to, lotions, creams, gels, toothpastes, or combinations thereof.", "Substances contacted by the disclosed opacity modifying agents exhibit high opacity.", "Lightness can be assessed by any suitable method, such as, for example, measuring the Lightness Index according to ASTM Method E313 with a D65/10° illumination source (referred to as “E313 [065/10]”) using a LabScan™ XE spectrophotometer (available from HunterLab, Inc.).", "A sample can be prepared, for instance, by dispersing 5% by weight of an opacity modifying agent into a substance such as a sugar syrup comprising two-parts sucrose to one-part water by weight.", "A sample can also be prepared by coating a substrate with the aforementioned dispersion.", "A sample is loaded into the instrument's sample port and scanned, and the Lightness Index (E313 [D65/10]) value is calculated using measurements taken on the CIE L*a*b* color scale.", "The resulting Lightness Index value is used to assess lightness of the sample.", "Suitably, substances contacted by the disclosed opacity modifying agents can exhibit high E313 [D65/10] values of at least about 50, at least about 55, at least about 60, at least about 65, at least about 70, at least about 75, at least about 80, at least about 85, at least about 90, at least about 91, at least about 92, at least about 93, at least about 94, at least about 95, at least about 96, at least about 97, or at least about 98.Suitably, the disclosed opacity modifying agents can increase the E313 [D65/10] values of a food product upon contacting said product by at least about 5, at least about 10, at least about 15, at least about 20, at least about 25, at least about 30, at least about 35, at least about 40, at least about 45, at least about 50, at least about 55, at least about 60, at least about 65, at least about 70, at least about 75, at least about 80, at least about 85, at least about 90, at least about 95, at least about 96, or at least about 97.Opacity can be assessed by evaluating the Lightness.", "Index achieved upon coating one or more colored substrate cores with film coatings as described herein.", "For example, when coating a colored substrate, the Lightness Index will increase with additional weight gain until high and/or full opacity is reached.", "Upon reaching high and/or full opacity, the Lightness Index may level off relative to further increases in weight gain.", "Suitably, the disclosed film coatings can suitably provide high and/or full opacity at a weight gain of less than about 10%, less than about 9%, less than about 8%, less than about 7%, less than about 6%, less than about 5%, or less than about 4%, at least about 0.01%, at least about 0.1%, at least about 0.5%, at least about 1%, at least about 2%, at least about 3%, or at least about 4% weight gain, for example, about 3% to about 10% weight gain.", "In some embodiments, the disclosed opacity modifying agent is present in amounts sufficient to provide full/high opacity at low weight gain.", "In some embodiments, substances contacted by the disclosed opacity modifying agents may exhibit an increase in L* as measured in reflectance mode or a decrease in L* as measured in transmission mode of at least about 0.01%, at least about 0.1%, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1%, at least about 1.25%, at least about 1.5%, at least about 1.75%, at least about 2%, at least about 2.25%, at least about 2.5%, at least about 3%, at least about 3.5%, at least about 4%, at least about 4.5%, at least about 5%, at least about 6%, at least about 7%, at least about 8%, at least about 9%, at least about 10%, at least about 11%, at least about 12%, at least about 13%, at least about 14%, or at least about 15% compared with substances contacted by a corresponding starch in an amount by weight equal to the amount by weight of the agent or the amount by weight of the starch in the agent, but not contacted by a dextrin, a film former or a binder.", "In some embodiments, substances contacted by the disclosed opacity modifying agents may exhibit an increase in L* as measured in reflectance mode or a decrease in L* as measured in transmission mode of at least about 0.01%, at least about 0.1%, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1%, at least about 1.25%, at least about 1.5%, at least about 1.75%, at least about 2%, at least about 2.25%, at least about 2.5%, at least about 3%, at least about 3.5%, at least about 4%, at least about 4.5%, at least about 5%, at least about 6%, at least about 7%, at least about 8%, at least about 9%, at least about 10%, at least about 11%, at least about 12%, at least about 13%, at least about 14%, or at least about 15% compared with substances contacted by a corresponding dextrin in an amount by weight equal to the amount by weight of the agent or the amount by weight of the dextrin in the agent, but without a starch and without the corresponding film former and binder.", "In some embodiments, substances contacted by the disclosed opacity modifying agents may exhibit an increase in L* as measured in reflectance mode or a decrease in L* as measured in transmission mode of at least about 0.01%, at least about 0.1%, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1%, at least about 1.25%, at least about 1.5%, at least about 1.75%, at least about 2%, at least about 2.25%, at least about 2.5%, at least about 3%, at least about 3.5%, at least about 4%, at least about 4.5%, at least about 5%, at least about 10%, at least about 15%, at least about 20%, at least about 25%, at least about 30%, at least about 35%, at least about 40%, at least about 45%, at least about 50%, at least about 55%, at least about 60%, at least about 65%, at least about 70%, or at least about 75% compared with substances contacted by a corresponding film former or binder in amounts by weight equal to the amount by weight of the agent or the amounts by weight of the film former or binder in the agent, but without starch and without dextrin.", "In some embodiments, substances coated by coatings containing the disclosed opacity modifying agents may exhibit an increase in L* as measured in reflectance mode of at least about 0.01%, at least about 0.1%, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1%, at least about 1.25%, at least about 1.5%, at least about 1.75%, at least about 2%, at least about 2.25%, at least about 2.5%, at least about 3%, at least about 3.5%, at least about 4%, at least about 4.5%, at least about 5%, at least about 6%, at least about 7%, at least about 8%, at least about 9%, at least about 10%, at least about 11%, at least about 12%, at least about 13%, at least about 14%, or at least about 15% compared with substances coated by a coating containing a corresponding starch in an amount by weight equal to the amount by weight of the agent or the amount by weight of the starch in the agent, but not containing a dextrin, a film former or a binder.", "In some embodiments, substances coated by coatings containing the disclosed opacity modifying agents may exhibit an increase in L* as measured in reflectance mode of at least about 0.01%, at least about 0.1%, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1%, at least about 1.25%, at least about 1.5%, at least about 1.75%, at least about 2%, at least about 2.25%, at least about 2.5%, at least about 3%, at least about 3.5%, at least about 4%, at least about 4.5%, at least about 5%, at least about 6%, at least about 7%, at least about 8%, at least about 9%, at least about 10%, at least about 11%, at least about 12%, at least about 13%, at least about 14%, or at least about 15% compared with substances coated by coatings containing a corresponding dextrin in an amount by weight equal to the amount by weight of the agent or the amount by weight of the dextrin in the agent, but without a starch and without the corresponding film former and binder.", "In some embodiments, substances coated by coatings containing the disclosed opacity modifying agents may exhibit an increase in L* as measured in reflectance mode of at least about 0.01%, at least about 0.1%, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1%, at least about 1.25%, at least about 1.5%, at least about 1.75%, at least about 2%, at least about 2.25%, at least about 2.5%, at least about 3%, at least about 3.5%, at least about 4%®, at least about 4.5%®, at least about 5%, at least about 10%, at least about 15%, at least about 20%, at least about 25%, at least about 30%, at least about 35%, at least about 40%, at least about 45%, at least about 50%, at least about 55%, at least about 60%, at least about 65%, at least about 70%, or at least about 75% compared with substances coated by coatings containing a corresponding film former or binder in amounts by weight equal to the amount by weight of the agent or the amounts by weight of the film former or binder in the agent, but without starch and without dextrin.", "Substances contacted by the disclosed opacity modifying agents may exhibit high brightness.", "Brightness can assessed by any suitable method, such as, for example, using a LabScan™ XE spectrophotometer to measure the amount of light reflected at 457 nm.", "A sample is loaded into the instrument's sample port and scanned, and the resulting reflectance at 457 nm is used to assess brightness of the sample.", "Suitably, the substances contacted by the disclosed opacity modifying agent may have a high brightness value of at least about 80, at least about 81, at least about 82, at least about 83, at least about 84, at least about 85, at least about 86, at least about 87, at least about 88, at least about 89, at least about 90, at least about 91, at least about 92, at least about 93, at least about 94, at least about 95, at least about 96, or at least about 97.In some embodiments, the disclosed opacity modifying agent is present in amounts sufficient to provide high brightness.", "Substances contacted by the disclosed opacity modifying agents may exhibit increased index of refraction.", "Index of refraction can be measured by any suitable method, such as, for example, dispersing 5% by weight of an opacity modifying agent into a sugar syrup comprising two-parts sucrose to one-part water by weight and measuring the increase in index of refraction using a temperature compensated Leica 10432 hand-held refractometer.", "In some instances, the change in index of refraction can be represented by a change in the degrees Brix value.", "Suitably, substances contacted by the disclosed opacity modifying agents may exhibit an increase in degrees Brix value of at least about 0.01%, at least about 0.1%, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1%, at least about 1.25%, at least about 1.5%, at least about 1.75%, at least about 2%, at least about 2.25%, at least about 2.5%, at least about 3%, at least about 3.5%, at least about 4%, at least about 4.5%, at least about 5%, at least about 6%, at least about 7%, at least about 8%, at least about 9%, at least about 10%, at least about 11%, at least about 12%, at least about 13%, at least about 14%, at least about 15%, at least about 16%, at least about 17%, at least about 18%, at least about 19%, at least about 20%, at least about 21%, at least about 22%, at least about 23%, at least about 24%, or at least about 25% when compared with the substance not contacted by the opacity modifying agent.", "In some embodiments, the disclosed opacity modifying agent is present in amounts sufficient to provide high index of refraction.", "In some embodiments, substances contacted by the disclosed opacity modifying agents may exhibit an increase in degrees Brix value of at least about 0.01%, at least about 0.1%, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1%, at least about 1.25%, at least about 1.5%, at least about 1.75%, at least about 2%, at least about 2.25%, at least about 2.5%, at least about 3%, at least about 3.5%, at least about 4%, at least about 4.5%, at least about 5%, at least about 6%, at least about 7%, at least about 8%, at least about 9%, or at least about 10% compared with substances contacted by a corresponding starch in an amount by weight equal to the amount by weight of the agent or the amount by weight of the starch in the agent, but not contacted by a dextrin, and without, the corresponding film former and binder.", "In some embodiments, substances contacted by the disclosed opacity modifying agents may exhibit an increase in degrees Brix value of at least about 0.01%, at least about 0.1%, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1%, at least about 1.25%, at least about 1.5%, at least about 1.75%, at least about 2%, at least about 2.25%, at least about 2.5%, at least about 3%, at least about 3.5%, at least about 4%, at least about 4.5%, at least about 5%, at least about 10%, at least about 15%, at least about 20%, at least about 25%, at least about 30%, at least about 35%, at least about 40%, at least about 45%, or at least about 50% compared with substances contacted by the corresponding film former and binder but without starch and without dextrin.", "The compositions and suspensions described herein can be manufactured using techniques and equipment that are known and commonly used in the art.", "Manufacturing steps such as order of component addition, mixing temperatures (heating and/or cooling), mixing time, mixing speed, etc.", "can be driven by either by formulation or equipment requirements, or both.", "A number of parameters can be modified during the manufacturing process without substantial effect on the efficacy of the resulting product.", "The manufacturing methods and processes can further include separate steps for validating the resulting composition (e.g., the total amounts, ratios, and even distribution of components in the composition, etc.).", "The following examples are provided for illustrative purposes only and should not be construed as limiting.", "EXAMPLES Materials.", "“Rice Starch” is a native rice starch with roughly 12-13% moisture content that has been processed to remove excess protein and fat, having a bulk density of roughly 0.49 g/ml, particle size of less than 0.18 mm, and rice granule size of roughly 2-8 microns.", "PenPure® 30 is a native rice starch (available commercially from Penford Food Ingredients, Centennial, Colo.).", "ClearGum® LG 7015 is a high amylose starch (available commercially from Roquette America, Keokuk, Iowa).", "Ultra-sperse® corn starch is a corn starch (available commercially from Ingredion, Westchester, Ill.).", "Ultra-sperse® 3 is a starch derived from tapioca (available commercially from Ingredion, Westchester, Ill.).", "Thingum 107 is a native corn starch (available commercially from Tate & Lyle, London, England).", "Tic.", "Pretested® Gum Arabic SD FCC Powder is a spray dry powder gum arabic produced from the exudate from acacia trees (available commercially from Tic Gum, White Marsh, Md.).", "Ticaxan® Xanthan Gum Powder is an all-natural thickener and stabilizer (available commercially from Tic Gum, White Marsh, Md.).", "Maltrine® M040 Maltodextrin is a 5 dextrose equivalent, bland, white, powdered carbohydrate (available commercially from Grain Processing Corp., Muscatine, Iowa).", "K 4484 is a specialty dextrin refined from tapioca starch (available commercially from National Starch Food Innovation, Bridgewater, N.J.).", "Spectracel 15 FG is a low-viscosity hydroxypropyl methyl cellulose where the viscosity of a 2% solution in water measure at 20° C. is from 12.0 cP to 18.0 cP (available commercially from Sensient Colors, St. Louis, Mo.).", "Crillet® 4 Veg GMO-free polysorbate 80 is an ethoxylated sorbitan ester emulsifier (available commercially from Croda, Lanchashire, England).", "Topcithin® SF is a clean label, non-GM, sunflower lecithin sunflower lecithin that does not require labeling as an allergin (available commercially from Cargill, Minnetonka, Minn.).", "Propylparaben NF and Methylparaben NF (available commercially from Malinckrodt, St Louis, Mo.).", "Sodium benzoate, H3PO4, citric acid, ascorbic acid, and potassium sorbate (available commercially from Apac Corp., Arcadia, Calif.).", "“Fusion White” is a commercially available opacity modifying agent containing rice starch, tapioca starch, and sunflower lecithin, but no film former or dextrin (available commercially from Sensient Food Colors Europe, Geesthacht, Germany).", "Example 1 Opacity Modifying Agents Prepared by Spray Drying Spray dried compositions detailed in Table 1 were prepared by mixing the dry ingredients in a mix chamber of a plow mixer (Littleford; Florence, Ky.).", "Liquid components were added to the chamber to form the spray dry composition.", "The spray dry compositions were spray dried on a Buchi mini spray dryer B-290 to produce opacity modifying agents according to this invention.", "Values are reported in percent by weight of the composition.", "TABLE 1 Spray Dry Compositions.", "Agent Component 1-A 1-B 1-C 1-D 1-E 1-F Water 90.0 90.0 90.0 90.0 90.0 90.0 Rice Starch 8.5 8.5 8.5 8.5 8.5 8.5 Maltodextrin 0.8 0.8 0.8 0.8 0.8 0.8 HPMC E-15 0.422 0.390 0.370 0.400 0.310 0.470 GMO-Free 0.13 0.13 0.13 0.13 0.13 0.13 Polysorbate 80 Sunflower 0.10 0.10 0.10 0.10 0.10 0.10 Lecithin Methyl Paraben 0.04 Propyl Paraben 0.008 Sodium 0.06 0.06 Benzoate Solution (1.5M) H3PO4 Solution 0.02 0.02 (5.3M) Ascorbic Acid 0.10 0.10 Potassium 0.05 Sorbate Example 2 Opacity Modifying Agents Prepared by Dry Mixing The opacity modifying agents of Table 2 were prepared by mixing the ingredients in a mix chamber of a plow mixer.", "Values are reported in percent by weight of the composition.", "TABLE 2 Opacity Modifying Agents.", "Agent Component 2-A 2-B Rice Starch 80 85 Maltodextrin 10 8 Sunflower Lecithin 3 1 Gum Arabic SD 7 HPMC E-15 6 Example 3 Formulations The opacity modifying agents of Tables 3 and 4 were prepared according to the methods of this invention.", "Values are reported in percent by weight of the composition.", "Opacity experiments were performed by coating colored substrates with film coatings containing the opacity modifying agents.", "The opacity performance was evaluated by visual inspection and the results are reported in Tables 3 and 4.TABLE 3 Opacity Modifying Agents.", "Agent Component 3-A 3-B 3-C 3-D 3-E 3-F 3-G 3-H 3-I 3-J 3-K Rice Starch 70 ClearGum ® 70 80 LG 7015 Ultra-sperse ® 70 80 Ultra-sperse ® 3 70 80 PenPure ® 30 70 90 Thingum ™107 70 80 Maltodextrin 20 20 10 20 10 20 10 20 5 20 10 Sunflower 7 7 7 7 7 7 7 7 3 7 7 Lecithin Gum Arabic 3 3 3 3 3 3 3 3 2 3 3 SD Visual Ok Ok Ok Ok Good Ok Ok Ok Ok Ok Ok Inspection TABLE 4 Opacity Modifying Agents.", "Agent Component 3-L 3-M 3-N Rice Starch 80 80 80 Maltodextrin 10 10 K 4484 10 Sunflower Lecithin 3 3 3 Gum Arabic SD 7 HPMC E-15 7 Xanthan Gum 7 Visual Inspection Ok Good Good Example 4 Opacity Modifying Agent The opacity modifying agent shown in Table 5 was prepared by combining the ingredients with water using an Oster blender to make a composition containing 20% by weight opacity modifying agent and 80% by weight water.", "The resulting composition was spray dried on a Buchi B-290 spray drier set to a 200° C. inlet temperature, a 90° C. outlet temperature, and an 18% pump rate.", "After spray drying, the opacity modifying Agent 4 contained 5.65% moisture.", "Values are reported in percent by weight of the composition.", "TABLE 5 Opacity Modifying Agent.", "Component Agent 4 Citric Acid 0.10 Ascorbic Acid 0.40 Potassium Sorbate 1.50 Sunflower Lecithin 0.50 HPMC E-15 4.75 Maltodextrin 7.75 Rice Starch 85.00 Example 5 Refractive Index A 66° Bx sugar syrup having 2 parts sucrose to 1 part water was prepared as a carrier.", "1%, 5%, 10%, and 15% by weight compositions of Agent 4 and Rice Starch were prepared using the 66° Bx sugar syrup as carrier.", "The refractive index of each composition was measured using a Leica 10432 44-77° Brix Hand-held Refractometer.", "The 1%, 5%, 10%, and 15% by weight compositions of Agent 4 exhibited a measured refractive index of 67.5° Bx, 68° Bx, 69° Bx, and 70° Bx, respectively.", "The 1%, 5%, 10%, and 15% by weight compositions of Rice Starch exhibited a measured refractive index of 66° Bx, 66° Bx, 66.5° Bx, and 66.5° Bx, respectively.", "Example 6 Colorimetry of Sugar Syrups Containing Opacity Modifying Agents The compositions of Table 6 were prepared with a sugar syrup having 2 parts sucrose to 1 part water as a carrier.", "20 mL of the resulting compositions was placed in a clean cuvette and introduced into an X-Rite Color i-5 Colorimeter using a 25-mm port in total transmission mode.", "The resulting colorimetry data are shown in Table 6.ΔE values were computed using the sugar syrup as a control.", "dL* values are a comparison between the L* value of a composition containing Agent 4 at a certain percent weight and the composition containing an individual component of Agent 4 at the same percent weight.", "dΔE values are a comparison between the ΔE value of a composition containing Agent 4 at a certain percent weight and the composition containing an individual component of Agent 4 at the same percent weight.", "TABLE 6 Colorimetry of Sugar Syrups.", "Conc.", "(% w/w Composition Component Carrier) L* a* b* ΔE dL* dΔE 6-Control Sugar Syrup 100 95.77 −0.18 1.48 0 0 0 6-1 Agent 4 1 50.44 −0.57 1.93 45.33 0 0 6-2 Agent 4 5 42.98 0.05 4.45 52.87 0 0 6-3 Agent 4 10 34.54 −0.06 5.95 61.39 0 0 6-4 Agent 4 15 24.71 1.18 10.94 71.70 0 0 6-5 Rice Starch 1 63.61 0.19 2.99 32.20 −13.17 13.13 6-6 Rice Starch 5 44.44 −0.21 2.84 51.35 −1.46 1.52 6-7 Rice Starch 10 39.51 −0.29 3.92 56.31 −4.97 5.08 6-8 Rice Starch 15 33.89 −0.29 5.05 61.98 −9.18 9.72 6-9 Maltodextrin 1 93.48 −0.2 1.09 2.32 −43.04 43.01 6-10 Maltodextrin 5 75.4 −0.2 0.94 20.38 −32.42 32.49 6-11 Maltodextrin 10 46.99 −0.09 2.15 48.78 −12.45 12.61 6-12 Maltodextrin 15 39.28 0.44 2.75 56.51 −14.57 15.19 6-13 HPMC E-15 1 86.37 −0.37 1.45 9.40 −35.93 35.93 6-14 HPMC E-15 5 51.74 −0.8 4.23 44.12 −8.76 8.75 6-15 HPMC E-15 10 43.79 −1.48 8.42 52.46 −9.25 8.93 6-16 HPMC E-15 15 44.17 −1.5 8.68 52.12 −19.46 19.58 Example 7 Colorimetry of Panned Dragees 120 mL of a composition containing 5% by weight of Sensient Brown Lake Aqueous Dispersion (available commercially from Sensient Colors, St. Louis, Mo.)", "in a 68° Bx sugar syrup was applied to 2000 grams of naked dragees over 12 coat applications using a hard panning technique to produce brown coated dragees.", "25 mL of each of compositions 6-Control and 6-1 to 6-16 were applied to 100 grams of naked dragees and 400 grams of brown coated dragees over 10 coat applications using a hard panning technique to produce final dragees for measuring colorimetry data.", "The colorimetry data were measured on final dragees produced from brown coated dragees.", "Colorimetry data were measured using an X-Rite Color i-5 Colorimeter operating in total reflectance mode.", "The resulting colorimetry data are shown in Table 7.“Coating Comp.” indicates the composition that was applied to coat the brown coated dragees.", "ΔE values were computed using the brown coated dragees as a control.", "dL* values are a comparison between the L* value of a final dragee (produced from a brown coated dragee) that was coated by a composition containing Agent 4 at a certain percent weight and the composition containing an individual component of Agent 4 at the same percent weight.", "dL* (SS) values are a comparison between the L* value of a final dragee (produced from a brown coated dragee) coated by the indicated composition and a final dragee (produced from a brown coated dragee) coated by a sugar syrup (composition 6-Control).", "dΔE values are a comparison between the ΔE value of a final dragee (produced from a brown coated dragee) that was coated by a composition containing Agent 4 at a certain percent weight and the composition containing an individual component of Agent 4 at the same percent weight.", "dΔE (SS) values are a comparison between the ΔE value of a final dragee (produced from a brown coated dragee) coated by the indicated composition and a final dragee (produced from a brown coated dragee) coated by a sugar syrup (composition 6-Control).", "FIG.", "1 shows the results of panning application for Dragees 7-1 (top row), 7-2 (second row from top), 7-3 (second row from bottom), and 7-4 (bottom row).", "The rows are arranged such that the rightmost dragee contains 1 coat, the 2nd-rightmost dragee contains 2 coats, etc., the 2nd-leftmost dragee contains 9 coats, and the leftmost dragee contains 10 coats.", "TABLE 7 Colorimetry of Coated Dragees.", "Coating dL* dΔE Dragee Comp.", "L* a* b* ΔE dL* dΔE (SS) (SS) 7- None 51.49 8.64 5.92 0.00 0.00 0.00 −8.19 11.08 Control 7-1 6-1 58.12 1.60 1.40 10.67 0.00 0.00 −1.56 3.55 7-2 6-2 74.61 0.75 −2.31 25.78 0.00 0.00 14.93 15.50 7-3 6-3 74.87 0.82 −2.61 26.09 0.00 0.00 15.19 15.78 7-4 6-4 75.49 1.03 −2.34 26.50 0.00 0.00 15.81 16.30 7-5 6-5 67.04 2.42 −2.29 18.65 8.92 9.69 7.36 7.89 7-6 6-6 67.51 1.50 −2.40 19.41 −7.10 7.14 7.83 8.62 7-7 6-7 68.36 1.35 −2.59 20.25 −6.51 6.53 8.68 9.49 7-8 6-8 72.09 1.48 −2.20 23.27 −3.40 3.43 12.41 12.90 7-9 6-9 66.03 2.30 3.42 16.06 7.91 8.19 6.35 7.59 7-10 6-10 67.72 2.58 −1.50 18.85 −6.89 7.17 8.04 8.34 7-11 6-11 64.95 3.99 −1.26 15.95 −9.92 10.50 5.27 5.39 7-12 6-12 49.96 6.04 1.68 5.20 −25.53 26.33 −9.72 10.04 7-13 6-13 58.91 1.85 −1.62 12.57 0.79 3.13 −0.77 2.98 7-14 6-14 61.47 2.82 1.07 12.53 −13.14 13.72 1.79 2.68 7-15 6-15 63.67 3.78 −0.65 14.67 −11.20 11.75 3.99 4.06 7-16 6-16 59.46 2.47 −1.80 12.70 −16.03 16.10 −0.22 2.49 7-17 6-Control 59.68 4.36 −0.20 11.08 −15.81 16.30 0.00 0.00 Example 8 Colorimetry of Dry Powder Samples of Agent 4, anatase titanium dioxide (available commercially from Sensient Colors, St. Louis, Mo.)", "and eggshell calcium carbonate (available commercially from Sensient Colors, St. Louis, Mo.)", "were introduced to an X-Rite Color i-5 Colorimeter operating in total reflectance mode and colorimetry data were acquired, which are presented in Table 8.dL* is the difference in L* relative to titanium dioxide.", "TABLE 8 Colorimetry of Dry Powder.", "Component L* a* b* dL* Titanium Dioxide 97.14 −0.27 0.67 0 Calcium Carbonate 93.39 −0.24 1.81 −3.75 Agent 4 97.89 −1.51 3.94 0.75 Example 9 Particle Size Analysis Samples of Agent 4, anatase titanium dioxide (available commercially from Sensient Colors, St. Louis, Mo.)", "eggshell calcium carbonate (available commercially from Sensient Colors, St. Louis, Mo.)", "and Fusion White were introduced to a Malvern liquid particle size analyzer using Microtrac version 10.2.1 software.", "Results of the particle size analysis are shown in Table 9.TABLE 9 Particle Size Analysis.", "mean smallest largest particle size particle size particle size Component (μm) measured (μm) measured (μm) Agent 4 46.23 1.156 352 Titanium Dioxide 6.83 0.061 74 Calcium Carbonate 168.7 1.635 418.6 Fusion White 67.88 1.156 418.6 Example 10 Comparison with Titanium Dioxide and Calcium Carbonate Agent 4, anatase titanium dioxide (available commercially from Sensient Colors, St. Louis, Mo.)", "and eggshell calcium carbonate (available commercially from Sensient.", "Colors, St. Louis, Mo.)", "were each added to a separate sugar syrup to form a coating composition that is 5% by weight of its respective additive.", "Naked chocolate dragees were coated with each of the coating compositions to the same weight gain.", "Dragees coated with the composition containing Agent 4 exhibited slightly more opacity in the coating than dragees coated with the composition containing calcium carbonate.", "Dragees coated with the composition containing Agent 4 exhibited weaker opacity in the coating than dragees coated with the composition containing titanium dioxide.", "Example 11 Comparison with Fusion White Two kilograms of chocolate dragees were coated with a coating composition containing 3.1 g of FD&C Blue No.", "1 in 1 kg of sugar syrup to produce blue coated dragees.", "Half of the blue coated dragees were coated by a hard panning method with 100 g of a composition containing 0.55% by weight of Agent 2-B of Example 2 and the remainder sugar syrup.", "The other half of the blue coated dragees were coated by a hard panning method with 100 g of a composition containing 11% by weight of Fusion White and the remainder sugar syrup.", "FIG.", "11 shows the comparative coating effect of blue coated dragees coated with Fusion White (left two columns, with dragees from top to bottom containing an increasing number of coats) versus the coating effect of blue coated dragees coated with Agent 2-B (right two columns, with dragees from top to bottom containing an increasing number coats).", "Visual inspection indicated that the coating effect was slightly improved in dragees coated with Agent 2-B over dragees coated with a comparable number of coats of Fusion white.", "However, the coating composition containing Fusion White was twenty-times more concentrated, indicating that Agent 2-B was at least twenty-times more effective as an opacity modifying agent as Fusion white.", "During panning with the composition containing Fusion White, there was significant development of dust, however, during panning with the composition containing Agent 2-B, there was no significant formation of dust." ] ]
Patent_15872646
[ [ "High Authority Stability and Control Augmentation System", "A system and method of increasing the control authority of redundant stability and control augmentation system (SCAS) actuators by utilizing feedback between systems such that one system may compensate for the position of a failed actuator of the other system.", "Each system uses an appropriate combination of reliable and unreliable inputs such that unreliable inputs cannot inappropriately utilize the increased authority.", "Each system may reconfigure itself when the other system actuator fails at certain positions so that the pilot or other upstream input maintains sufficient control authority of the aircraft." ], [ "1.A method for increasing the authority of a stability and control augmentation system, comprising: providing a first actuator; grouping robust inputs into a first group of inputs; grouping non-robust inputs into a second group of inputs; processing the first group of inputs into trusted commands for the actuator; processing the second group of inputs into un-trusted commands for the actuator; providing a set of limits for the un-trusted commands; limiting the contribution of the un-trusted commands based on the set of limits to form limited un-trusted commands; and summing the trusted commands with the limited un-trusted commands, wherein the robust inputs are monitored.", "2.A rotary aircraft having a rotary system carried by a fuselage, the rotary system comprising: a first flight control computer carried by the fuselage, the first flight control computer having; a first processor for commanding the first actuator along a first axis; and a second processor for commanding the first actuator along the first axis; a second flight control computer carried by the fuselage; a first actuator commanded by the first flight control computer for manipulating the rotary system along the first axis; a second actuator commanded by the second flight control computer for manipulating the rotary system along the first axis; and a third actuator for manipulating the rotary system along the first axis; wherein the first actuator compares commands from the first processor of the first flight control computer to commands from the second processor of the first flight control computer to find a failure in the first actuator; and wherein an output of the first actuator is summed with an output of the second actuator and summed with a control input for manipulating the rotary system with full authority in only the first axis by controlling the third actuator." ], [ "<SOH> BACKGROUND <EOH>" ], [ "BACKGROUND 1.Field of the Invention The present application relates generally to flight control systems, and more specifically, to an aircraft flight control system for allowing an augmentation system to have higher authorities, for example up to full authority, on an aircraft that has a mechanical flight control system.", "2.Description of Related Art Previous attempts to provide higher authority on Stability and Control Augmentation Systems (SCAS) have relied upon mechanical limits.", "For example, some SCAS actuators are mechanically limited in authority to mitigate the effects of a failure resulting in actuator seizure or undesired motion.", "Other SCAS actuators use spring mechanisms to center the SCAS actuators upon a failure.", "Actuator authority is limited mechanically to mitigate the effects of undesired motion resulting from a failure including the sudden recentering which will result if a failure occurs while the actuator is working near its extreme position.", "None of the previous attempts provide high authority.", "DESCRIPTION OF THE DRAWINGS The novel features believed characteristic of the embodiments of the present application are set forth in the appended claims.", "However, the embodiments themselves, as well as a preferred mode of use, and further objectives and advantages thereof, will best be understood by reference to the following detailed description when read in conjunction with the accompanying drawings, wherein: FIG.", "1 is a side view of a rotary aircraft; FIG.", "2 is a schematic of the high authority stability and control augmentation system according to the preferred embodiment of the present application; FIG.", "3a is a schematic of the flight control system according to the preferred embodiment of the present application; and FIG.", "3b is a schematic of the processor according to the preferred embodiment of the present application.", "While the system and method of the present application are susceptible to various modifications and alternative forms, specific embodiments thereof have been shown by way of example in the drawings and are herein described in detail.", "It should be understood, however, that the description herein of specific embodiments is not intended to limit the invention to the particular embodiment disclosed, but on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the process of the present application as defined by the appended claims.", "DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT The system and method of the present application overcomes the abovementioned limitations commonly associated with conventional SCAS actuators.", "The system improves optionally manned aircraft by fixing the input controls and using the SCAS with high authority to control the aircraft in flight.", "Further description and illustration of the high authority stability and control system and method is provided in the figures and disclosure below.", "It will of course be appreciated that in the development of any actual embodiment, numerous implementation-specific decisions will be made to achieve the developer's specific goals, such as compliance with system-related and business-related constraints, which will vary from one implementation to another.", "Moreover, it will be appreciated that such a development effort might be complex and time-consuming, but would nevertheless be a routine undertaking for those of ordinary skill in the art having the benefit of this disclosure.", "The system and method of the present application will be understood, both as to its structure and operation, from the accompanying drawings, taken in conjunction with the accompanying description.", "Several embodiments of the system are presented herein.", "It should be understood that various components, parts, and features of the different embodiments may be combined together and/or interchanged with one another, all of which are within the scope of the present application, even though not all variations and particular embodiments are shown in the drawings.", "It should also be understood that the mixing and matching of features, elements, and/or functions between various embodiments is expressly contemplated herein so that one of ordinary skill in the art would appreciate from this disclosure that the features, elements, and/or functions of one embodiment may be incorporated into another embodiment as appropriate, unless described otherwise.", "Referring now to the drawings, FIG.", "1 shows a rotary aircraft utilizing the flight control system of the present application.", "FIG.", "1 shows a side view of a helicopter 101.However, it will be appreciated that the control system is easily and readily adaptable for use with other types of rotary aircraft, i.e., helicopter 101, operating at various speeds and with or without a fixed lateral cyclic control.", "Helicopter 101 comprises a rotary system 103 carried by a fuselage 105.One or more rotor blades 107 operably associated with rotary system 103 provide flight for helicopter 101 and are controlled with a plurality of controllers within fuselage 105.For example, during flight a pilot can manipulate the cyclic controller 109 for changing the pitch angle of rotor blades 107, thus providing lateral and longitudinal flight direction, and/or manipulate pedals 111 for controlling yaw direction.", "Helicopter 101 includes a dual Automatic Flight Control System (AFCS).", "For ease of description, some of the required systems and devices operably associated with the present control system are not shown, i.e., sensors, connectors, power sources, mounting supports, circuitry, software, and so forth, in order to clearly depict the novel features of the system.", "However, it should be understood that the system of the present application is operably associated with these and other required systems and devices for operation, as conventionally known in the art, although not shown in the drawings.", "Referring now also to FIG.", "2 in the drawings, a schematic of a high authority stability and control augmentation system 203 is shown.", "The high authority stability and control augmentation system 203 allows for significantly enhanced aircraft automation by allowing an augmentation system to have higher authorities (up to full authority) on an aircraft that has a mechanical flight control system.", "The high authority stability and control augmentation system 203 is comprised of a first flight control computer (FCC) 205, a second FCC 207, a first actuator 209 typically a SCAS actuator, a second actuator 211 typically a SCAS actuator, and a flight control actuator 213.As typical between FCC's the first FCC 205 is in communication with the second FCC 207.First actuator 209 is summed with second actuator 211 which both are summed with input 215.The summation can be mechanical, for example, the actuators can move a control rod.", "Alternatively, the summation can be electrical, for example, a digital or analog signal of the actuators can be summed together with other signals.", "Preferably, input 215 is from the pilot input into the controls, such as lateral or longitudinal cyclic controls 109; however other upstream inputs to the aircraft control axis, such as trim actuators are contemplated by this application.", "It should be apparent that each axis of control requires a dual system (System 1 and System 2) 203 and that for clarity sake only a single axis of controls is shown.", "Furthermore, each system (1 and 2), at least in regard to flight critical functionality such as rate sensor inputs, processing, and output monitoring, may be dual and self-checking.", "Any disagreement within either system can allow that system to shut down its associated SCAS actuator and therefore no single failure would result in erroneous movement of the SCAS actuator.", "Rather, single failures within either system would result in the SCAS actuator associated with the failed system holding fixed in position.", "First actuator 209 is dual commanded from the first FCC 205 by a first command 217a and a second command 217b each being sourced from one of two self checking processors within the first FCC 205.First actuator 209 is smart and also self checking and therefore can compare the first command 217a to the second command 217b and can use other means to otherwise monitor the health of the commanding FCCs outputs.", "In one embodiment, first actuator 209 provides dual status and positional feedback 219 to the second FCC 207.While comparing first command 217a to the second command 217b, if the first actuator 209 senses a significant disagreement between the first command 217a and the second command 217b or any other indication of failures of the commanding FCC such as lack of command updates, the actuator 209 fails itself fixed in place.", "If the first actuator 209 fails fixed in place the second FCC 207 may then compensate for the fixed position of the first actuator 209 by changing its commands to second actuator 211.For example, as long as the first actuator 209 is working properly the status signals 219 are held to a high voltage.", "If the first actuator 209 fails the status signals 219 are driven low.", "The second FCC 207 receiving the failed status 219 from the first actuator 209 and utilizing the last known position information 219, may command the second actuator 211 to a different position to mitigate the failed position of the first actuator 209 so that the control input 215 retains sufficient control authority of the aircraft.", "Second actuator 211 is dual commanded 221 from the second FCC 207.Second actuator 211 provides dual status and positional feedback 223 to the first FCC 205.Inputs 225 to first FCC 205 and to second FCC 207 are comprised of typical inputs to FCCs such as: positional information from the controls via displacement transducers; attitudes and attitude rates; pitch rates; airframe accelerations; airspeed; engine parameters; rotor parameters; and transmission parameters.", "Similarly to above, if the second actuator 211 fails, the first FCC 205 then compensates for the failed second actuator 211.Referring now also to FIG.", "3a in the drawings, a schematic of an improved FCC 205 having a high authority stability and control augmentation system 203 is illustrated.", "The first FCC 205 includes a first processor 235 and a second processor 239.First processor 235 provides the first command 217a to the first actuator 209, and the second processor 239 provides the second command 217b to the first actuator 209.The two processors compare their respective interpretations of inputs 225 and computed outputs 217a and 217b.", "Any disagreement, will force SCAS actuator 1 to fail fixed.", "In one embodiment, this can be accomplished by sending commands that are recognized by the first actuator 209 as commands to fail fixed.", "In the preferred embodiment the SCAS actuators are SMART and compare the first command to the second command.", "In an alternative embodiment the FCCs control the position of the SCAS actuators directly and status and position feedback to the other system is therefore sourced from the FCCs.", "In such case, the internal redundant configuration of the SCAS actuators would be accomplished within the redundant configuration of the FCCs.", "Referring now also to FIG.", "3b in the drawings, a schematic of the algorithms implemented within each processor 235 and 239 is illustrated.", "Located inside each processor 235 and 239 are a first set of computational algorithms 253, a second set of computational algorithms 257, limits 261, and a summation 265.Preferably computational algorithms 253 are software based however in an alternative embodiment computational algorithms 253 are comprised of analog hardware monitoring and responding to inputs 225.Limits 225 are grouped into trusted inputs and into un-trusted inputs.", "The first computational algorithms 253 utilize input type 225a or trusted inputs.", "Input type 225a consists of inputs that are monitored sufficiently and robustly enough to guarantee the validity of the data supplied to the first computational algorithm 253.Examples of monitored inputs 225a include attitude rates and pitch rates.", "First computational algorithm 253 determines a part of the actuator command 217a dependent upon the specific input from the input type 225a.", "For example the first computational algorithm 253 adjusts the actuator command 217a based upon a falling attitude rate.", "Input types 225b or un-trusted inputs are inputs that are not necessarily reliable and are supplied to the second set of computational algorithms 257.An example of an unreliable input 225b may be airspeed.", "Second computational algorithm 257 determines a part of the actuator command 217a dependent upon the specific input from the input type 225b.", "Limits 261, limit the contribution of the output of the second set of computational algorithms 257 to the actuator commands 217a and 217b.", "Limit 261 is configured to limit the unreliable input 225b to a magnitude that has been determined safe for the helicopter 101 were it to be incorrect data.", "In another embodiment, limits to inputs 225b may exist prior to computational algorithms 257.In yet another embodiment, additional computational algorithms may exist at the output of the summing element 265.It is the appropriate combination of these two classes of inputs 225a and 225b that allow the system 203 the advantages resulting from higher authority while maintaining safety.", "When the actuator in one system fails as a fixed position, the remaining system, based on the status and position feedback from the failed system, may configure new position command limits such that any subsequent failure in the remaining system would result in a net position in which the sum of both actuator positions is within a range sufficient for the pilot or other upstream input to retain sufficient control of the aircraft.", "Upon detection of the first failure, the remaining system may act to command the unfailed actuator to within the newly established limits if necessary to accomplish the objective.", "The system and method described herein solves the limitation of limited automatic control authority by incorporating feedback, mitigation algorithms, and computation limiting to a traditional mechanically limited dual system.", "It is apparent that a system and method with significant advantages has been described and illustrated.", "The particular embodiments disclosed above are illustrative only, as the embodiments may be modified and practiced in different but equivalent manners apparent to those skilled in the art having the benefit of the teachings herein.", "It is therefore evident that the particular embodiments disclosed above may be altered or modified, and all such variations are considered within the scope and spirit of the application.", "Accordingly, the protection sought herein is as set forth in the description.", "Although the present embodiments are shown above, they are not limited to just these embodiments, but are amenable to various changes and modifications without departing from the spirit thereof." ] ]
Patent_15872651
[ [ "METHODS OF TRANSPLANTING CHONDROCYTES", "Provided are tri-component matrices having collagen, hyaluronan, and chondroitin sulfate.", "Also provided are processes for producing a tri-component matrix.", "Additionally, provided are processes for providing cells capable of producing cartilage to a bone or cartilage defects." ], [ "1.A tri-component matrix comprising: a) isolated and purified non-denatured type II collagen; b) hyaluronan; and c) chondroitin sulfate.", "2.The tri-component matrix of claim 1, further comprising water.", "3.The tri-component matrix of claim 1, further comprising a basal media.", "4.The tri-component matrix of claim 3, wherein the basal media is Medium 199.5.The tri-component matrix of claim 1, wherein the type II collagen is bovine-derived type II collagen.", "6.The tri-component matrix of claim 1, wherein the concentration of type II collagen is from about 0.5 mg/ml to about 5 mg/ml.", "7.The tri-component matrix of claim 6, wherein the concentration of type II collagen is about 3 mg/ml.", "8.The tri-component matrix of claim 1, wherein the concentration of hyaluronan is from about 0.25 mg/ml to about 3 mg/ml.", "9.The tri-component matrix of claim 8, wherein the concentration of hyaluronan is about 1 mg/ml.", "10.The tri-component matrix of claim 1, wherein the concentration of chondroitin sulfate is from about 0.25 mg/ml to about 3 mg/ml.", "11.The tri-component matrix of claim 10, wherein the concentration of chondroitin sulfate is about 1 mg/ml.", "12.The tri-component matrix of claim 1, further comprising chondrocytes, chondroprogenitor cells, mesenchymal stem cells, induced pluripotent stem cells (iPS cells), iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox-9 transduced chondrocytes, osteoblasts, osteoprogenitors, or any combinations thereof.", "13.The tri-component matrix of claim 12, further comprising chondrocytes.", "14.The tri-component matrix of claim 12, further comprising chondroprogenitor cells.", "15.The tri-component matrix of claim 12, further comprising iPS cells.", "16.A process for producing a transplantation composition for cartilage engineering comprising: a) dissolving isolated and purified non-denatured type II collagen in a solution comprising an acid, wherein the final concentration of type II collagen is from about 0.5 mg/ml to about 5 mg/ml; b) neutralizing the acid; c) adding from about 0.25 mg/ml to about 3 mg/ml of hyaluronan; and d) adding from about 0.25 mg/ml to about 3 mg/ml of chondroitin sulfate, wherein a tri-component matrix is produced.", "17.The process of claim 16, wherein the acid is acetic acid.", "18.The process of claim 16, wherein the acetic acid is at a concentration of about 0.01 M. 19.The process of claim 16, wherein the acetic acid is neutralized with NaHCO3/HEPES.", "20.The process of claim 16, wherein the tri-component matrix comprises Medium 199.21.The process of claim 16, wherein hyaluronan is added at a concentration of about 1 mg/ml.", "22.The process of claim 16, wherein chondroitin sulfate is added at a concentration of about 1 mg/ml.", "23.The process of claim 16, wherein the final concentration of type II collagen is about 3 mg/ml.", "24.The process of claim 16, further comprising adding chondrocytes, chondroprogenitor cells, mesenchymal stem cells, iPS cells, iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox-9 transduced chondrocytes, or any combinations thereof, to the tri-component matrix.", "25.The process of claim 24 further comprising adding chondrocytes to the tri-component matrix.", "26.The process of claim 24, further comprising adding chondroprogenitor cells to the tri-component matrix.", "27.The process of claim 24, further comprising adding iPS cells to the tri-component matrix.", "28.A method for inducing endogenous cartilage growth in a subject in need thereof, including the step of implanting in the subject the tri-component matrix as recited in claim 1.29.A method of treating a bone or cartilage defect in a subject in need thereof, comprising administering a transplantation composition comprising: i) a tri-component matrix, as claimed in claim 1, and ii) a population of cells, at the site of the bone or cartilage defect.", "30.The method of claim 29, wherein the population of cells comprises chondrocytes, chondroprogenitor cells, iPS cells, mesenchymal stem cells, osteoblasts, osteoprogenitors, or combinations thereof.", "31.The method of claim 29, wherein new tissue is produced.", "32.The method of claim 31, wherein the new tissue restores the surface of the cartilage or bone.", "33.The method of claim 31, wherein the new tissue comprises collagen type II.", "34.The method of claim 31, wherein the new tissue comprises superficial, intermediate, and deep zones characteristic of normal articular cartilage.", "35.The method of claim 34, wherein the superficial zone of the new tissue comprises lubricin.", "36.The method of claim 31, wherein the new tissue does not comprise teratomas, neoplastic cells, evidence of deformation, abnormal architectural features, or other inappropriate cell types.", "37.The method of claim 29, the population of cells comprises chondrocytes.", "38.The method of claim 29, the population of cells comprises chondroprogenitor cells.", "39.The method of claim 29, the population of cells comprises iPS cells.", "40.The method of claim 39, wherein the iPS cells are derived from chondrocytes.", "41.The method of claim 38, wherein the chondroprogenitor cells are H9-derived chondroprogenitor cells.", "42.The method of claim 37, wherein the chondrocytes are Sox-9 transduced chondrocytes.", "43.A method of treating a cartilage-related disorder in a subject in need thereof, comprising administering a mixture of a tri-component matrix, as claimed in claim 1, and chondrocytes, chondroprogenitor cells, mesenchymal stem cells, iPS cells, iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox-9 transduced chondrocytes, osteoblasts, osteoprogenitors, or any combinations thereof, to a site of cartilage injury or defect.", "44.A method according to claim 43, wherein the the cartilage-related disorder is articular cartilage trauma, meniscus injury, a chonodrogenesis disorder, arthritis, chondropathy, chondrosarcoma, chondromalacia, polychondritis, relapsing polychondritis, slipped epiphysis, osteochondritis dissecans, chondrodysplasia, costochondritis, osteochondroma, spondylosis, osteochondroses, Tietze syndrome, dermochondrocorneal dystrophy of Francois, epiphyseal dysplasia, carpotarsal osteochondromatosis, achondropasia, chondrocalcinosis, genochondromatosis, chondroma, achondrogenesis, echondromata, hyprochondroplasia, or Keutel syndrome.", "45.The method of claim 44, wherein the cartilage-related disorder is arthritis.", "46.The method of claim 45, wherein the arthritis is osteoarthritis.", "47.The method of claim 46, wherein the osteoarthritis occurs in the knee, finger, wrist, hip, spine, shoulder, elbow, toe, ankle, or neck of a subject.", "48.A cartilage repair implant comprising: a) a tri-component matrix according to claim 1; and b) cells selected from chondrocytes, chondroprogenitor cells, mesenchymal stem cells, iPS cells, iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox-9 transduced chondrocytes, osteoblasts, osteoprogenitors, or any combinations thereof.", "49.The cartilage repair implant of claim 48, further comprising a biomaterial substrate, wherein the biomaterial substrate is selected from: polyglycolic acid (PGA), polylactic acid, alginates, polyethylene oxide, fibrin adhesive, polylactic acid-polyglycolic acid copolymer, human dermis, a membrane such as a sheet, a porous body such as sponges, a mesh such as a knit, a textile, a non-woven fabric, cotton, porous material, or combinations thereof." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>Disclosed herein, in some embodiments, is a tri-component matrix comprising: a) isolated and purified non-denatured type II collagen; b) hyaluronan; and c) chondroitin sulfate.", "In some embodiments, the tri-component matrix further comprises water.", "In some embodiments, the tri-component matrix further comprises a basal media.", "In some embodiments, the basal media is Medium 199.In some embodiments, the type II collagen is bovine-derived type II collagen.", "In some embodiments, the concentration of type II collagen is from about 0.5 mg/ml to about 5 mg/ml.", "In some embodiments, the concentration of type II collagen is about 3 mg/ml.", "In some embodiments, the concentration of hyaluronan is from about 0.25 mg/ml to about 3 mg/ml.", "In some embodiments, the concentration of hyaluronan is about 1 mg/ml.", "In some embodiments, the concentration of chondroitin sulfate is from about 0.25 mg/ml to about 3 mg/ml.", "In some embodiments, the concentration of chondroitin sulfate is about 1 mg/ml.", "In some embodiments, the tri-component matrix further comprises chondrocytes, chondroprogenitor cells, mesenchymal stem cells, induced pluripotent stem cells (iPS cells), iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox-9 transduced chondrocytes, osteoblasts, osteoprogenitors, or any combinations thereof.", "In some embodiments, the tri-component matrix further comprises chondrocytes.", "In some embodiments, the tri-component matrix further comprises chondroprogenitor cells.", "In some embodiments, the tri-component matrix further comprises iPS cells.", "Disclosed herein, in some embodiments, is a process for producing a transplantation composition for cartilage engineering comprising: a) dissolving isolated and purified non-denatured type II collagen in a solution comprising an acid, wherein the final concentration of type II collagen is from about 0.5 mg/ml to about 5 mg/ml; b) neutralizing the acid; c) adding from about 0.25 mg/ml to about 3 mg/ml of hyaluronan; and d) adding from about 0.25 mg/ml to about 3 mg/ml of chondroitin sulfate, wherein a tri-component matrix is produced.", "In some embodiments, the acid is acetic acid.", "In some embodiments, the acetic acid is at a concentration of about 0.01 M. In some embodiments, the acetic acid is neutralized with NaHCO 3 /HEPES.", "In some embodiments, the tri-component matrix comprises Medium 199.In some embodiments, the hyaluronan is added at a concentration of about 1 mg/ml.", "In some embodiments, the chondroitin sulfate is added at a concentration of about 1 mg/ml.", "In some embodiments, the final concentration of type II collagen is about 3 mg/ml.", "In some embodiments, the process further comprises adding chondrocytes, chondroprogenitor cells, mesenchymal stem cells, iPS cells, iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox-9 transduced chondrocytes, or any combinations thereof, to the tri-component matrix.", "In some embodiments, the process further comprises adding chondrocytes to the tri-component matrix.", "In some embodiments, the process further comprises adding chondroprogenitor cells to the tri-component matrix.", "In some embodiments, the process further comprises adding iPS cells to the tri-component matrix.", "Disclosed herein, in some embodiments, is a method for inducing endogenous cartilage growth in a subject in need thereof, including the step of implanting in the subject a tri-component matrix as disclosed herein.", "Disclosed herein, in some embodiments, is a method of treating a bone or cartilage defect in a subject in need thereof, comprising administering a transplantation composition comprising: i) a tri-component matrix, as disclosed herein, and ii) a population of cells, at the site of the bone or cartilage defect.", "In some embodiments, the population of cells comprises chondrocytes, chondroprogenitor cells, iPS cells, mesenchymal stem cells, osteoblasts, osteoprogenitors, or combinations thereof.", "In some embodiments, new tissue is produced.", "In some embodiments, the new tissue restores the surface of the cartilage or bone.", "In some embodiments, the new tissue comprises collagen type II.", "In some embodiments, the new tissue comprises superficial, intermediate, and deep zones characteristic of normal articular cartilage.", "In some embodiments, the superficial zone of the new tissue comprises lubricin.", "In some embodiments, the new tissue does not comprise teratomas, neoplastic cells, evidence of deformation, abnormal architectural features, or other inappropriate cell types.", "In some embodiments, the population of cells comprises chondrocytes.", "In some embodiments, the population of cells comprises chondroprogenitor cells.", "In some embodiments, the population of cells comprises iPS cells.", "In some embodiments, the iPS cells are derived from chondrocytes.", "In some embodiments, the chondroprogenitor cells are H9-derived chondroprogenitor cells.", "In some embodiments, the chondrocytes are Sox-9 transduced chondrocytes.", "Disclosed herein, in some embodiments, is a method of treating a cartilage-related disorder in a subject in need thereof, comprising administering a mixture of a tri-component matrix, as claimed in claim 1 , and chondrocytes, chondroprogenitor cells, mesenchymal stem cells, iPS cells, iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox-9 transduced chondrocytes, osteoblasts, osteoprogenitors, or any combinations thereof, to a site of cartilage injury or defect.", "In some embodiments, the cartilage-related disorder is articular cartilage trauma, meniscus injury, a chonodrogenesis disorder, arthritis, chondropathy, chondrosarcoma, chondromalacia, polychondritis, relapsing polychondritis, slipped epiphysis, osteochondritis dissecans, chondrodysplasia, costochondritis, osteochondroma, spondylosis, osteochondroses, Tietze syndrome, dermochondrocorneal dystrophy of Francois, epiphyseal dysplasia, carpotarsal osteochondromatosis, achondropasia, chondrocalcinosis, genochondromatosis, chondroma, achondrogenesis, echondromata, hyprochondroplasia, or Keutel syndrome.", "In some embodiments, the cartilage-related disorder is arthritis.", "In some embodiments, the arthritis is osteoarthritis.", "In some embodiments, the osteoarthritis occurs in the knee, finger, wrist, hip, spine, shoulder, elbow, toe, ankle, or neck of a subject.", "Disclosed herein, in some embodiments, is a cartilage repair implant comprising: a) a tri-component matrix, as disclosed herein; and b) cells selected from chondrocytes, chondroprogenitor cells, mesenchymal stem cells, iPS cells, iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox- 9 transduced chondrocytes, osteoblasts, osteoprogenitors, or any combinations thereof.", "In some embodiments, the cartilage repair implant further comprises a biomaterial substrate, wherein the biomaterial substrate is selected from: polyglycolic acid (PGA), polylactic acid, alginates, polyethylene oxide, fibrin adhesive, polylactic acid-polyglycolic acid copolymer, human dermis, a membrane such as a sheet, a porous body such as sponges, a mesh such as a knit, a textile, a non-woven fabric, cotton, porous material, or combinations thereof." ], [ "CROSS-REFERENCE This application is a continuation of U.S. application Ser.", "No.", "14/438,583, filed Apr.", "24, 2015, which is a U.S. National Stage entry of International Application No.", "PCT/US2013/067349, field Oct. 29, 2013, which claims the benefit of U.S.", "Application Ser.", "No.", "61/719,902, filed Oct. 29, 2012, all of which are herein incorporated by reference in their entireties.", "SUMMARY OF THE INVENTION Disclosed herein, in some embodiments, is a tri-component matrix comprising: a) isolated and purified non-denatured type II collagen; b) hyaluronan; and c) chondroitin sulfate.", "In some embodiments, the tri-component matrix further comprises water.", "In some embodiments, the tri-component matrix further comprises a basal media.", "In some embodiments, the basal media is Medium 199.In some embodiments, the type II collagen is bovine-derived type II collagen.", "In some embodiments, the concentration of type II collagen is from about 0.5 mg/ml to about 5 mg/ml.", "In some embodiments, the concentration of type II collagen is about 3 mg/ml.", "In some embodiments, the concentration of hyaluronan is from about 0.25 mg/ml to about 3 mg/ml.", "In some embodiments, the concentration of hyaluronan is about 1 mg/ml.", "In some embodiments, the concentration of chondroitin sulfate is from about 0.25 mg/ml to about 3 mg/ml.", "In some embodiments, the concentration of chondroitin sulfate is about 1 mg/ml.", "In some embodiments, the tri-component matrix further comprises chondrocytes, chondroprogenitor cells, mesenchymal stem cells, induced pluripotent stem cells (iPS cells), iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox-9 transduced chondrocytes, osteoblasts, osteoprogenitors, or any combinations thereof.", "In some embodiments, the tri-component matrix further comprises chondrocytes.", "In some embodiments, the tri-component matrix further comprises chondroprogenitor cells.", "In some embodiments, the tri-component matrix further comprises iPS cells.", "Disclosed herein, in some embodiments, is a process for producing a transplantation composition for cartilage engineering comprising: a) dissolving isolated and purified non-denatured type II collagen in a solution comprising an acid, wherein the final concentration of type II collagen is from about 0.5 mg/ml to about 5 mg/ml; b) neutralizing the acid; c) adding from about 0.25 mg/ml to about 3 mg/ml of hyaluronan; and d) adding from about 0.25 mg/ml to about 3 mg/ml of chondroitin sulfate, wherein a tri-component matrix is produced.", "In some embodiments, the acid is acetic acid.", "In some embodiments, the acetic acid is at a concentration of about 0.01 M. In some embodiments, the acetic acid is neutralized with NaHCO3/HEPES.", "In some embodiments, the tri-component matrix comprises Medium 199.In some embodiments, the hyaluronan is added at a concentration of about 1 mg/ml.", "In some embodiments, the chondroitin sulfate is added at a concentration of about 1 mg/ml.", "In some embodiments, the final concentration of type II collagen is about 3 mg/ml.", "In some embodiments, the process further comprises adding chondrocytes, chondroprogenitor cells, mesenchymal stem cells, iPS cells, iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox-9 transduced chondrocytes, or any combinations thereof, to the tri-component matrix.", "In some embodiments, the process further comprises adding chondrocytes to the tri-component matrix.", "In some embodiments, the process further comprises adding chondroprogenitor cells to the tri-component matrix.", "In some embodiments, the process further comprises adding iPS cells to the tri-component matrix.", "Disclosed herein, in some embodiments, is a method for inducing endogenous cartilage growth in a subject in need thereof, including the step of implanting in the subject a tri-component matrix as disclosed herein.", "Disclosed herein, in some embodiments, is a method of treating a bone or cartilage defect in a subject in need thereof, comprising administering a transplantation composition comprising: i) a tri-component matrix, as disclosed herein, and ii) a population of cells, at the site of the bone or cartilage defect.", "In some embodiments, the population of cells comprises chondrocytes, chondroprogenitor cells, iPS cells, mesenchymal stem cells, osteoblasts, osteoprogenitors, or combinations thereof.", "In some embodiments, new tissue is produced.", "In some embodiments, the new tissue restores the surface of the cartilage or bone.", "In some embodiments, the new tissue comprises collagen type II.", "In some embodiments, the new tissue comprises superficial, intermediate, and deep zones characteristic of normal articular cartilage.", "In some embodiments, the superficial zone of the new tissue comprises lubricin.", "In some embodiments, the new tissue does not comprise teratomas, neoplastic cells, evidence of deformation, abnormal architectural features, or other inappropriate cell types.", "In some embodiments, the population of cells comprises chondrocytes.", "In some embodiments, the population of cells comprises chondroprogenitor cells.", "In some embodiments, the population of cells comprises iPS cells.", "In some embodiments, the iPS cells are derived from chondrocytes.", "In some embodiments, the chondroprogenitor cells are H9-derived chondroprogenitor cells.", "In some embodiments, the chondrocytes are Sox-9 transduced chondrocytes.", "Disclosed herein, in some embodiments, is a method of treating a cartilage-related disorder in a subject in need thereof, comprising administering a mixture of a tri-component matrix, as claimed in claim 1, and chondrocytes, chondroprogenitor cells, mesenchymal stem cells, iPS cells, iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox-9 transduced chondrocytes, osteoblasts, osteoprogenitors, or any combinations thereof, to a site of cartilage injury or defect.", "In some embodiments, the cartilage-related disorder is articular cartilage trauma, meniscus injury, a chonodrogenesis disorder, arthritis, chondropathy, chondrosarcoma, chondromalacia, polychondritis, relapsing polychondritis, slipped epiphysis, osteochondritis dissecans, chondrodysplasia, costochondritis, osteochondroma, spondylosis, osteochondroses, Tietze syndrome, dermochondrocorneal dystrophy of Francois, epiphyseal dysplasia, carpotarsal osteochondromatosis, achondropasia, chondrocalcinosis, genochondromatosis, chondroma, achondrogenesis, echondromata, hyprochondroplasia, or Keutel syndrome.", "In some embodiments, the cartilage-related disorder is arthritis.", "In some embodiments, the arthritis is osteoarthritis.", "In some embodiments, the osteoarthritis occurs in the knee, finger, wrist, hip, spine, shoulder, elbow, toe, ankle, or neck of a subject.", "Disclosed herein, in some embodiments, is a cartilage repair implant comprising: a) a tri-component matrix, as disclosed herein; and b) cells selected from chondrocytes, chondroprogenitor cells, mesenchymal stem cells, iPS cells, iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox-9 transduced chondrocytes, osteoblasts, osteoprogenitors, or any combinations thereof.", "In some embodiments, the cartilage repair implant further comprises a biomaterial substrate, wherein the biomaterial substrate is selected from: polyglycolic acid (PGA), polylactic acid, alginates, polyethylene oxide, fibrin adhesive, polylactic acid-polyglycolic acid copolymer, human dermis, a membrane such as a sheet, a porous body such as sponges, a mesh such as a knit, a textile, a non-woven fabric, cotton, porous material, or combinations thereof.", "BRIEF DESCRIPTION OF THE DRAWINGS The novel features of the invention are set forth with particularity in the appended claims.", "A better understanding of the features and advantages of the present invention will be obtained by reference to the following detailed description that sets forth illustrative embodiments, in which the principles of the invention are utilized, and the accompanying drawings of which: FIG.", "1 exemplifies tissue repair by H9-derived chondroprogenitors and chondroprogenitors derived from adult human chondrocytes (CHON-1 and CHON-2).", "Alcian Blue and Safranin O staining was comparable between the H9-derived chondroprogenitors and the chondroprogenitors derived from adult human chondrocytes.", "Poor tissue repair was seen in empty osteochondral defects or osteochondral defects filled with only Matrigel.", "FIG.", "2 exemplifies tissue repair by H9-derived chondroprogenitors (H9-D MSC), adult human chondrocytes (chondrocyte), pluripotent cell-derived chondroprogenitors (IPSC), and adult human mesenchymal stem cells (Adult MSC).", "Cells were embedded in a tri-component matrix of type II collagen, chondroitin sulfate, and hyaluronic acid prior to surgical implantation.", "FIG.", "3 exemplifies mechanical stiffness of tissue generated by H9-derived chondroprogenitors (H9 Derived MSC), adult human chondrocytes, pluripotent cell-derived chondroprogenitors (IPSC derived from chondrocyte), and adult human mesenchymal stem cells (Adult Human MSC) which had been embedded in a tri-component matrix of type II collagen, chondroitin sulfate, and hyaluronic acid prior to surgical implantation.", "The exemplified units are Newtons/mm.", "FIG.", "4 exemplifies tissue repair by H9-derived chondroprogenitors and adult human chondrocyte derived chondroprogenitors.", "Cells were embedded in alginate prior to surgical implantation.", "DETAILED DESCRIPTION OF THE INVENTION Disclosed herein, in some embodiments, is a tri-component matrix comprising: a) isolated and purified non-denatured type II collagen; b) hyaluronan; and c) chondroitin sulfate.", "In some embodiments, the tri-component matrix further comprises water.", "In some embodiments, the tri-component matrix further comprises a basal media.", "In some embodiments, the basal media is Medium 199.In some embodiments, the type II collagen is bovine-derived type II collagen.", "In some embodiments, the concentration of type II collagen is from about 0.5 mg/ml to about 5 mg/ml.", "In some embodiments, the concentration of type II collagen is about 3 mg/ml.", "In some embodiments, the concentration of hyaluronan is from about 0.25 mg/ml to about 3 mg/ml.", "In some embodiments, the concentration of hyaluronan is about 1 mg/ml.", "In some embodiments, the concentration of chondroitin sulfate is from about 0.25 mg/ml to about 3 mg/ml.", "In some embodiments, the concentration of chondroitin sulfate is about 1 mg/ml.", "In some embodiments, the tri-component matrix further comprises chondrocytes, chondroprogenitor cells, mesenchymal stem cells, induced pluripotent stem cells (iPS cells), iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox-9 transduced chondrocytes, osteoblasts, osteoprogenitors, or any combinations thereof.", "In some embodiments, the tri-component matrix further comprises chondrocytes.", "In some embodiments, the tri-component matrix further comprises chondroprogenitor cells.", "In some embodiments, the tri-component matrix further comprises iPS cells.", "Disclosed herein, in some embodiments, is a process for producing a transplantation composition for cartilage engineering comprising: a) dissolving isolated and purified non-denatured type II collagen in a solution comprising an acid, wherein the final concentration of type II collagen is from about 0.5 mg/ml to about 5 mg/ml; b) neutralizing the acid; c) adding from about 0.25 mg/ml to about 3 mg/ml of hyaluronan; and d) adding from about 0.25 mg/ml to about 3 mg/ml of chondroitin sulfate, wherein a tri-component matrix is produced.", "In some embodiments, the acid is acetic acid.", "In some embodiments, the acetic acid is at a concentration of about 0.01 M. In some embodiments, the acetic acid is neutralized with NaHCO3/HEPES.", "In some embodiments, the tri-component matrix comprises Medium 199.In some embodiments, the hyaluronan is added at a concentration of about 1 mg/ml.", "In some embodiments, the chondroitin sulfate is added at a concentration of about 1 mg/ml.", "In some embodiments, the final concentration of type II collagen is about 3 mg/ml.", "In some embodiments, the process further comprises adding chondrocytes, chondroprogenitor cells, mesenchymal stem cells, iPS cells, iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox-9 transduced chondrocytes, or any combinations thereof, to the tri-component matrix.", "In some embodiments, the process further comprises adding chondrocytes to the tri-component matrix.", "In some embodiments, the process further comprises adding chondroprogenitor cells to the tri-component matrix.", "In some embodiments, the process further comprises adding iPS cells to the tri-component matrix.", "Disclosed herein, in some embodiments, is a method for inducing endogenous cartilage growth in a subject in need thereof, including the step of implanting in the subject a tri-component matrix as disclosed herein.", "Disclosed herein, in some embodiments, is a method of treating a bone or cartilage defect in a subject in need thereof, comprising administering a transplantation composition comprising: i) a tri-component matrix, as disclosed herein, and ii) a population of cells, at the site of the bone or cartilage defect.", "In some embodiments, the population of cells comprises chondrocytes, chondroprogenitor cells, iPS cells, mesenchymal stem cells, osteoblasts, osteoprogenitors, or combinations thereof.", "In some embodiments, new tissue is produced.", "In some embodiments, the new tissue restores the surface of the cartilage or bone.", "In some embodiments, the new tissue comprises collagen type II.", "In some embodiments, the new tissue comprises superficial, intermediate, and deep zones characteristic of normal articular cartilage.", "In some embodiments, the superficial zone of the new tissue comprises lubricin.", "In some embodiments, the new tissue does not comprise teratomas, neoplastic cells, evidence of deformation, abnormal architectural features, or other inappropriate cell types.", "In some embodiments, the population of cells comprises chondrocytes.", "In some embodiments, the population of cells comprises chondroprogenitor cells.", "In some embodiments, the population of cells comprises iPS cells.", "In some embodiments, the iPS cells are derived from chondrocytes.", "In some embodiments, the chondroprogenitor cells are H9-derived chondroprogenitor cells.", "In some embodiments, the chondrocytes are Sox-9 transduced chondrocytes.", "Disclosed herein, in some embodiments, is a method of treating a cartilage-related disorder in a subject in need thereof, comprising administering a mixture of a tri-component matrix, as claimed in claim 1, and chondrocytes, chondroprogenitor cells, mesenchymal stem cells, iPS cells, iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox-9 transduced chondrocytes, osteoblasts, osteoprogenitors, or any combinations thereof, to a site of cartilage injury or defect.", "In some embodiments, the cartilage-related disorder is articular cartilage trauma, meniscus injury, a chonodrogenesis disorder, arthritis, chondropathy, chondrosarcoma, chondromalacia, polychondritis, relapsing polychondritis, slipped epiphysis, osteochondritis dissecans, chondrodysplasia, costochondritis, osteochondroma, spondylosis, osteochondroses, Tietze syndrome, dermochondrocorneal dystrophy of Francois, epiphyseal dysplasia, carpotarsal osteochondromatosis, achondropasia, chondrocalcinosis, genochondromatosis, chondroma, achondrogenesis, echondromata, hyprochondroplasia, or Keutel syndrome.", "In some embodiments, the cartilage-related disorder is arthritis.", "In some embodiments, the arthritis is osteoarthritis.", "In some embodiments, the osteoarthritis occurs in the knee, finger, wrist, hip, spine, shoulder, elbow, toe, ankle, or neck of a subject.", "Disclosed herein, in some embodiments, is a cartilage repair implant comprising: a) a tri-component matrix, as disclosed herein; and b) cells selected from chondrocytes, chondroprogenitor cells, mesenchymal stem cells, iPS cells, iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox-9 transduced chondrocytes, osteoblasts, osteoprogenitors, or any combinations thereof.", "In some embodiments, the cartilage repair implant further comprises a biomaterial substrate, wherein the biomaterial substrate is selected from: polyglycolic acid (PGA), polylactic acid, alginates, polyethylene oxide, fibrin adhesive, polylactic acid-polyglycolic acid copolymer, human dermis, a membrane such as a sheet, a porous body such as sponges, a mesh such as a knit, a textile, a non-woven fabric, cotton, porous material, or combinations thereof.", "Cartilage Articular cartilage is a type of hyaline cartilage that lines the surfaces of the opposing bones in a diarthrodial joint (e.g.", "knee, hip, shoulder, etc.).", "Articular cartilage provides a near-frictionless articulation between the bones, while also functioning to absorb and transmit the compressive and shear forces encountered in the joint.", "Further, since the tissue associated with articular cartilage is aneural, these load absorbing and transmitting functions occur in a painless fashion in a healthy joint.", "Fibrocartilage is found in diarthrodial joints, symphyseal joints, intervertebral discs, articular discs, as inclusions in certain tendons that wrap around a pulley, and at insertion sites of ligaments and tendons into bone.", "Made of a mixture of collagen type I and type II fibers, fibrocartilage may be damaged, causing pain in the affected joint.", "It is understood for purposes of this application that the term “cartilage” includes articular cartilage and fibrocartilage.", "Tri-Component Implant Matrix Disclosed herein are novel materials useful for medical grafting and cell culture, and methods for making and using them.", "Additional embodiments as well as features and advantages of the invention will be apparent from the descriptions herein.", "Disclosed herein, in some embodiments, is a tri-component matrix.", "In some embodiments, the tri-component matrix comprises collagen; hyaluronan; and chondroitin sulfate.", "In some embodiments, the collagen is type II collagen.", "In some embodiments, the collagen is non-denatured.", "In some embodiments, the tri-component matrix further comprises water.", "In some embodiments, the tri-component matrix further comprises chondrocytes or chondroprogenitor cells.", "In some embodiments, the tri-component matrix further comprises mesenchymal stem cells.", "In some embodiments, the tri-component matrix further comprises induced pluripotent stem (iPS) cells.", "In some embodiments, the tri-component matrix further comprises iPS cells derived from chondrocytes.", "In some embodiments, the tri-component matrix further comprises H9-derived chondroprogenitor cells.", "In some embodiments, the tri-component matrix further comprises Sox-9 transduced chondrocytes.", "In some embodiments, the tri-component matrix is a gel.", "In some embodiments, the tri-component matrix is a molded solid.", "In some embodiments, the tri-component matrix is a liquid.", "In some embodiments, the tri-component matrix further comprises a basal media.", "In some embodiments, the basal media is Medium 199, DMEM (for example, DMEM supplemented with fetal bovine serum), RPMI-1640, Ham's F-12, or any combinations thereof.", "In some embodiments, the basal media is a chondrocyte basal medium.", "In some embodiments, the basal media comprises the following components: Glycine; L-Alanine; L-Arginine hydrochloride; L-Aspartic acid; L-Cysteine hydrochloride-H2O; L-Cystine 2HCl; L-Glutamic Acid; L-Glutamine; L-Histidine hydrochloride-H2O; L-Hydroxyproline; L-Isoleucine; L-Leucine; L-Lysine hydrochloride; L-Methionine; L-Phenylalanine; L-Proline; L-Serine; L-Threonine; L-Tryptophan; L-Tyrosine disodium salt dehydrate; L-Valine; Alpha-tocopherol Phosphate; Ascorbic Acid; Biotin; Choline chloride; D-Calcium pantothenate; Folic Acid; Menadione (Vitamin K3); Niacinamide; Nicotinic acid (Niacin); Para-Aminobenzoic Acid; Pyridoxal hydrochloride; Pyridoxine hydrochloride; Riboflavin; Thiamine hydrochloride; Vitamin A (acetate); Vitamin D2 (Calciferol); i-Inositol; Calcium Chloride (CaCl2) (anhyd.", "); Ferric nitrate (Fe(NO3)—9H2O); Magnesium Sulfate (MgSO4) (anhyd.", "); Potassium Chloride (KCl); Sodium Bicarbonate (NaHCO3); Sodium Chloride (NaCl); Sodium Phosphate monobasic (NaH2PO4—H2O); 2-deoxy-D-ribose; Adenine sulfate; Adenosine 5′-phosphate; Adenosine 5′-triphosphate; Cholesterol; D-Glucose (Dextrose); Glutathione (reduced); Guanine hydrochloride; Hypoxanthine Na; Phenol Red; Ribose; Sodium Acetate; Thymine; Tween 80®; Uracil; and Xanthine-Na.", "In some embodiments, the basal media is Medium 199.In some embodiments, the basal media comprises platelet-derive growth factor (PDGF) (e.g., PDGF-BB, PDGF-AB, and PDGF-AA), a lipid (e.g., stearic acid, myristic acid, oleic acid, linoleic acid, palmitic acid, palmitoleic acid, arachidonic acid, linolenic acid, cholesterol, alpha-tocopherol acetate), bone morphogenic protein (BMP) (e.g., BMP-4 or BMP-6), TGF-ß (e.g., TGF-ß1, TGF-ß2, TGF-ß3), insulin-like growth factor (IGF), hydrocortisone, fibronectin, bFGF, albumin, insulin, FBS, or any combinations thereof.", "In some embodiments, the tri-component matrix comprises type II collagen (e.g., isolated and purified non-denatured type II collagen).", "In some embodiments, the type II collagen is non-denatured.", "In some embodiments, the tri-component matrix further comprises type VI, type IX, type X, type XI and/or type XIII collagen.", "In some embodiments, the type II collagen is derived from any suitable source.", "In some embodiments, the type II collagen is derived from a non-mammalian vertebrate (e.g., a shark).", "In some embodiments, the type II collagen is derived from a mammal.", "In some embodiments, the type II collagen is derived from a human In some embodiments, the type II collagen is derived from a non-human mammal.", "In some embodiments, the type II collagen is bovine-derive, equine-derive, or porcine-derived.", "In some embodiments, the type II collagen is bovine-derived type II collagen.", "In some embodiments, the concentration of type II collagen is from about 0.1 mg/ml to about 50 mg/ml.", "In some embodiments, the concentration of type II collagen is from about 0.5 mg/ml to about 25 mg/ml.", "In some embodiments, the concentration of type II collagen is from about 1 mg/ml to about 10 mg/ml.", "In some embodiments, the concentration of type II collagen is from about 1 mg/ml to about 5 mg/ml.", "In some embodiments, the concentration of type II collagen is about 3 mg/ml.", "Hyaluronan (also referred to as hyaluronic acid or HA) is an anionic, nonsulfated glycosaminoglycan.", "It is composed on disaccharides, composed of D-glucuronic acid and D-N-acetylglucosamine, linked via alternating ß-1,4 and ß-1,3 glycosidic bonds.", "The size of hyaluronan varies.", "Hyaluronans have been found with 25,000 disaccharide repeats.", "They range in size from 5,000 to 20,000,000 Da in vivo.", "The average molecular weight in human synovial fluid is 3-4 million Da, and hyaluronan purified from human umbilical cord is 3,140,000 Da.", "In some embodiments, the tri-component matrix comprises high molecular weight hyaluronan (i.e., greater than about 1000 Da).", "In some embodiments, the tri-component matrix comprises low molecular weight hyaluronan (i.e., less than about 1000 Da).", "In some embodiments, the tri-component matrix comprises hyaluronan having a size from about 500 Da to about 20,000,000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size from about 500 to about 5000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size from about 80,000 to about 800,000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size of about 1000 to about 15,000,000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size of about 2000 to about 10,000,000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size of about 3000 to about 7,500,000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size of about 4000 to about 5,000,000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size of about 5000 to about 2,500,000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size of about 6000 to about 1,000,000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size of about 7000 to about 900,000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size of about 8000 to about 800,000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size of about 9000 to about 700,000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size of about 10,000 to about 600,000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size of about 15,000 to about 500,000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size of about 20,000 to about 400,000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size of about 25,000 to about 300,000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size of about 30,000 to about 200,000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size of about 35,000 to about 200,000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size of about 40,000 to about 100,000 Da.", "In some embodiments, the tri-component matrix comprises hyaluronan having a size of about 50,000 to about 100,000 Da.", "In some embodiments, the concentration of hyaluronan is from about 0.1 mg/ml to about 25 mg/ml.", "In some embodiments, the concentration of hyaluronan is from about 0.25 mg/ml to about 10 mg/ml.", "In some embodiments, the concentration of hyaluronan is from about 0.25 mg/ml to about 5 mg/ml.", "In some embodiments, the concentration of hyaluronan is from about 0.25 mg/ml to about 3 mg/ml.", "In some embodiments, the concentration of hyaluronic acid is about 1 mg/ml.", "Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) composed of a chain of alternating sugars: N-acetyl-D-galactosamine (GalNAc) and D-glucuronic acid (GlcA).", "In certain instances, chondroitin chains have over 100 individual sugars, each of which can be sulfated in variable positions and quantities.", "Chondroitin sulfate is a structural component of cartilage.", "The tightly packed and highly charged sulfate groups of chondroitin sulfate generate electrostatic repulsion that provides much of the resistance of cartilage to compression.", "The site of sulfation varies amongst chondroitin chains Chondroitin sulfate A is sulfated on carbon 4 of the N-acetylgalactosamine (GalNAc) sugar.", "Chondroitin sulfate C is sulfated on carbon 6 of the GalNAc sugar.", "Chondroitin sulfate D is sulfated on carbon 2 of the glucuronic acid and 6 of the GalNAc sugar.", "Chondroitin sulfate E is sulfated on carbons 4 and 6 of the GalNAc sugar.", "In some embodiments, the tri-component matrix comprises any suitable chondroitin sulfate.", "In some embodiments, the tri-component matrix comprises Chondroitin sulfate A, Chondroitin sulfate C, Chondroitin sulfate D, and/or Chondroitin sulfate E. In some embodiments, the concentration of chondroitin sulfate is from about 0.1 mg/ml to about 25 mg/ml.", "In some embodiments, the concentration of chondroitin sulfate is from about 0.25 mg/ml to about 10 mg/ml.", "In some embodiments, the concentration of chondroitin sulfate is from about 0.25 mg/ml to about 5 mg/ml.", "In some embodiments, the concentration of chondroitin sulfate is from about 0.25 mg/ml to about 3 mg/ml.", "In some embodiments, the tri-component matrix is a medium for the ingrowth of native chondrocytes.", "In some embodiments, the matrix further comprises chondrocytes either prior to or following implantation in vivo.", "In some embodiments, the matrix is impregnated with chondrocytes immediately prior to implantation in a subject, e.g.", "by injection.", "In some embodiments, the tri-component matrix further comprises additional additives.", "In some embodiments, additional additives included in the tri-component matrix include, for example, chondronectin, laminin, fibronectin, calcium alginate, anchorin II, biglycan, decorin, versican, fibromodulin, lumican, bone, cartilage cell growth-promoting hormones, and growth factors such as cartilage inducing factor (CIP), insulin-like growth factor (IGF), IGF-1, transforming growth factor [beta] (TGFB), TGF-ß1, osteogenic protein-1 (OP-1) and bone morphogenetic factors (BMPs) such as native or recombinant human BMP-2, BMP-3 (osteogenin), BMP-4, BMP-7, BMP-8, bFGF, CDMP or other skeletal matrix molecules, as well as signaling peptides such as vascular endothelial growth factor (EGF/VEGF), parathyroid hormone related protein (PTHrP) and platelet derived growth factor (PDGF).", "In some embodiments, nucleic acid sequences (e.g., mammalian expression vectors) encoding any of the above listed additional additives, or which are capable of inducing or promoting in vivo production of the above listed additional additives, is incorporated into the tri-component matrix material.", "In some embodiments, the tri-component matrix further comprises an active agent.", "In some embodiments, the tri-component matrix further comprises an antibacterial agent, e.g., taurolidine, taurultam, or antibiotics such as tetracyclines and gentamycins.", "In some embodiments, the tri-component matrix further comprises an anti-inflammatory agent.", "In some embodiments, the tri-component matrix further comprises an NSAID.", "In some embodiments, the tri-component matrix further comprises celecoxib, oxaprozin, salsalate, diflunisal, indomethacin, meloxicam, ketorolac, diclofenac, naproxen, sulindac, tenoxicam, etodolac, nabumetone, piroxicam, carprofen, flubiprofen, ibuprofen, aspirin, paracetamol, or any combinations thereof.", "In some embodiments, the tri-component matrix further comprises a steroid, e.g., cortisone, hydrocortisone, prednisone, prednisolone, solumedrol, triamcinolone, kenalog, celestone, and depomedrol.", "In some embodiments, the tri-component matrix further comprises a disease-modifying anti-rheumatic drug (DMARD).", "In some embodiments, the tri-component matrix further comprises abatacept, adalimumab, azathioprine, chloroquine, hydroxychloroquine, Cyclosporin A, D-penicillamine, etanercept, golimumab, infliximab, leflunomide, methotrexate, minocycline, rituximab, sulfasalazine, or any combinations thereof.", "In some embodiments, the tri-component matrix further comprises an agent that prevents or reduces vascularization.", "Examples of agents that prevent or reduce vascularization include, but are not limited to, tyrosine kinase inhibitors, such as inhibitors of the tyrosine kinase receptors Flt-1 (VEGFR1) and Flk-1/KDR (VEGFR2), inhibitors of epidermal-derived, fibroblast-derived, or platelet derived growth factors, MMP (matrix metalloprotease) inhibitors, integrin blockers, interferon-a, interleukin-12, pentosan polysulfate, cyclooxygenase inhibitors, including nonsteroidal anti-inflammatories (NSAIDs) like aspirin and ibuprofen as well as selective cyclooxy-genase-2 inhibitors like celecoxib and rofecoxib steroidal anti-inflammatories (such as corticosteroids, mineralocorticoids, dexamethasone, prednisone, prednisolone, methylpred, betamethasone), carboxyamidotriazole, combretastatin A-4, squalamine, 6-O-chloroacetyl-carbonyl)-fumagillol, thalidomide, angiostatin, troponin-1, angiotensin II antagonists, and antibodies to VEGF.", "In some embodiments, the tri-component matrix disclosed herein elicits less of an inflammatory response than an alginate matrix.", "Methods of Culturing Cells The present invention also provides a method for culturing cells, comprising culturing cells in a tri-component matrix, as disclosed herein, comprising a) isolated and purified non-denatured type II collagen; b) hyaluronan; and c) chondroitin sulfate.", "In some embodiments, the cells within the tri-component matrix are cultured in a tissue culture vessel.", "In some embodiments, the tissue culture vessel is tissue culture-grade plastic.", "In some embodiments, the plastic is polystyrene.", "In some embodiments, the tissue culture vessel is glass.", "In some embodiments, the tri-component matrix further comprises a cell-culture media.", "In some embodiments, the cell-culture media is a basal media.", "In some embodiments, the basal media is Medium 199, DMEM (for example, DMEM supplemented with fetal bovine serum), RPMI-1640, Ham's F-12, or any combinations thereof.", "In some embodiments, the basal media is a chondrocyte basal medium.", "In some embodiments, the basal media comprises the following components: Glycine; L-Alanine; L-Arginine hydrochloride; L-Aspartic acid; L-Cysteine hydrochloride-H2O; L-Cystine 2HCl; L-Glutamic Acid; L-Glutamine; L-Histidine hydrochloride-H2O; L-Hydroxyproline; L-Isoleucine; L-Leucine; L-Lysine hydrochloride; L-Methionine; L-Phenylalanine; L-Proline; L-Serine; L-Threonine; L-Tryptophan; L-Tyrosine disodium salt dehydrate; L-Valine; Alpha-tocopherol Phosphate; Ascorbic Acid; Biotin; Choline chloride; D-Calcium pantothenate; Folic Acid; Menadione (Vitamin K3); Niacinamide; Nicotinic acid (Niacin); Para-Aminobenzoic Acid; Pyridoxal hydrochloride; Pyridoxine hydrochloride; Riboflavin; Thiamine hydrochloride; Vitamin A (acetate); Vitamin D2 (Calciferol); i-Inositol; Calcium Chloride (CaCl2) (anhyd.", "); Ferric nitrate (Fe(NO3)—9H2O); Magnesium Sulfate (MgSO4) (anhyd.", "); Potassium Chloride (KCl); Sodium Bicarbonate (NaHCO3); Sodium Chloride (NaCl); Sodium Phosphate monobasic (NaH2PO4—H2O); 2-deoxy-D-ribose; Adenine sulfate; Adenosine 5′-phosphate; Adenosine 5′-triphosphate; Cholesterol; D-Glucose (Dextrose); Glutathione (reduced); Guanine hydrochloride; Hypoxanthine Na; Phenol Red; Ribose; Sodium Acetate; Thymine; Tween 80®; Uracil; and Xanthine-Na.", "In some embodiments, the basal media is Medium 199.In some embodiments, the basal media comprises platelet-derive growth factor (PDGF) (e.g., PDGF-BB, PDGF-AB, and PDGF-AA), a lipid (e.g., stearic acid, myristic acid, oleic acid, linoleic acid, palmitic acid, palmitoleic acid, arachidonic acid, linolenic acid, cholesterol, alpha-tocopherol acetate), bone morphogenic protein (BMP) (e.g., BMP-4 or BMP-6), TGF-ß (e.g., TGF-ß1, TGF-ß2, TGF-ß3), insulin-like growth factor (IGF), hydrocortisone, fibronectin, bFGF, albumin, insulin, FBS, or any combinations thereof.", "Methods of Use Disclosed herein, in certain embodiments, are methods for inducing endogenous cartilage growth in a subject in need thereof, comprising implanting in the subject a tri-component matrix as disclosed herein, comprising a) isolated and purified non-denatured type II collagen; b) hyaluronan; and c) chondroitin sulfate.", "In some embodiments, the tri-component matrix further comprises chondrocytes and/or chondroprogenitor cells.", "In some embodiments, the method comprises injecting the tri-component into a cartilageonous area with a needle.", "In some embodiments, the method comprises injecting the tri-component matrix into a joint, e.g., a synovial joint.", "In some embodiments, the subject has a defect in cartilage (e.g., degeneration or absence of cartilage).", "In some embodiments, the subject has a cartilage related disorder.", "In some embodiments, the subject has osteoarthritis, rheumatoid arthritis, costochondritis, relapsing polychondritis, or any combinations thereof.", "In some embodiments, the subject has osteoarthritis.", "In some embodiments, the subject has rheumatoid arthritis.", "In some embodiments, the subject has damage to cartilage caused by a physical trauma.", "In some embodiments, a tri-component matrix disclosed herein is used for methods of regenerating cartilaginous tissue.", "In some embodiments, the tri-component matrix further comprises chondrocytes, chondroprogenitor cells, mesenchymal stem cells, iPS cells, iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox-9 transduced chondrocytes, osteoblasts, osteoprogenitors or any combinations thereof.", "In some embodiments, tri-component matrix is placed directly into an area of bone or cartilage defect.", "In some embodiments, the tri-component matrix is placed into an area of bone or cartilage defect with additional supportive biomaterial.", "In some embodiments, new cartilaginous tissue is formed.", "In some embodiments, the new cartilaginous tissue integrates with the tissue of the bone or cartilage defect.", "In some embodiments, the new cartilaginous tissue restores the surface of the cartilage or bone.", "In some embodiments, the new cartilaginous tissue comprises collagen type II.", "In some embodiments, the new cartilaginous tissue comprises superficial, intermediate, and deep zones characteristic of normal articular cartilage.", "In some embodiments, the superficial zone of the new cartilaginous tissue comprises lubricin.", "In some embodiments, the new cartilaginous tissue does not comprise teratomas, neoplastic cells, evidence of deformation, abnormal architectural features, or other inappropriate cell types.", "Disclosed herein, in some embodiments, is a method of treating a cartilage-related disorder, comprising administration of a tri-component matrix, as described herein, to a site of cartilage injury or defect in a subject in need thereof.", "In some embodiments, the tri-component matrix further comprises chondrocytes, chondroprogenitor cells, mesenchymal stem cells, iPS cells, iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox-9 transduced chondrocytes, osteoblasts, osteoprogenitors or any combinations thereof.", "In some embodiments, the cartilage-related disorder is articular cartilage trauma, meniscus injury, a chonodrogenesis disorder, arthritis, chondropathy, chondrosarcoma, chondromalacia, polychondritis, relapsing polychondritis, slipped epiphysis, osteochondritis dissecans, chondrodysplasia, costochondritis, osteochondroma, spondylosis, osteochondroses, Tietze syndrome, dermochondrocorneal dystrophy of Francois, epiphyseal dysplasia, carpotarsal osteochondromatosis, achondropasia, chondrocalcinosis, genochondromatosis, chondroma, achondrogenesis, echondromata, hyprochondroplasia, or Keutel syndrome.", "In some embodiments, the cartilage-related disorder is arthritis.", "In some embodiments, the arthritis is osteoarthritis.", "In some embodiments, the osteoarthritis occurs in the knee, finger, wrist, hip, spine, shoulder, elbow, toe, ankle, or neck of a subject.", "Disclosed herein, in some embodiments, is a cartilage repair implant comprising a tri-component matrix as disclosed herein, further comprising chondrocytes, chondroprogenitor cells, mesenchymal stem cells, iPS cells, iPS cells derived from chondrocytes, H9-derived chondroprogenitor cells, Sox-9 transduced chondrocytes, osteoblasts, osteoprogenitors or any combinations thereof.", "In some embodiments, the cartilage repair implant further comprises an additional biomaterial substrate.", "Examples of additional biomaterials include: polyglycolic acid (PGA), polylactic acid, alginates (for example, the calcium salt), polyethylene oxide, fibrin adhesive, polylactic acid-polyglycolic acid copolymer, proteoglycans, glycosaminoglycans, human dermis, or a combination thereof.", "In some embodiments, proteoglycans and glycosaminoglycans are sulfated.", "In some embodiments, the additional biomaterial substrate is a membrane such as sheet, a porous body such as sponges, a mesh such as a knit, a textile, a non-woven fabric, cotton and the like.", "In some embodiments, the additional biomaterial is a porous material.", "In some embodiments, the cartilage repair implant forms cartilage tissue and induces cartilaginous ossification.", "In some embodiments, ossification is also promoted by a growth factor which promotes bone formation, such as bone morphogenetic protein (BMP).", "Prior to transplantation of the described cartilage therapy materials, it is preferable to prepare the area that is to be treated.", "For this purpose, the defect must be prepared to ensure that the implant will take more effectively (particularly as regards its attachment), to reduce the risks of vascularization, etc.", "Generally, the defect is treated in advance (in order to eliminate all defective cartilage from the area), then it is cleaned.", "Next, various implantation techniques can be implemented, according to the material being implanted (suspension, matrix, cartilage reconstituted in vitro).", "Generally, implantation of the described cartilage therapy materials is performed by applying various surgical techniques known to the skilled person, such as affixing the implant during surgery, through biodegradable sutures or by the application of bioadhesives.", "Examples of bioadhesives include, notably, biological glues made of fibrin and/or thrombin, or other biocompatible materials.", "More particularly, the resorbable biocompatible film is affixed onto the area to be treated, by means of a biological or biocompatible glue.", "In a preferred variant, the film is positioned on the cartilaginous defect, then the pocket which is thus constituted is filled with cartilage therapy material.", "In some embodiments, the method for inducing endogenous cartilage growth further comprises athroscopic lavage and/or debridement of the area where the implant will be administered.", "In some embodiments, part or all of the damaged cartilage is removed and a tri-component matrix (for example, the tri-component matrix further comprising chondrocytes or chondroprogenitor cells) is implanted (e.g., injected) into the area.", "In some embodiments, the method for inducing endogenous cartilage growth further comprises marrow stimulating techniques (e.g., microfracture surgery).", "In some embodiments, (a) part or all of the damaged cartilage is removed from an area in need and underlying bone is partially or fully exposed, (b) microfractures are created in the subchondral bone (e.g., with the use of an awl), and (c) the tri-component matrix (for example, the tri-component matrix further comprising chondrocytes or chondroprogenitor cells) is implanted (e.g., injected) into the area.", "In some embodiments, the tri-component matrix (for example, the tri-component matrix further comprising chondrocytes or chondroprogenitor cells) is injected with any suitable needle, e.g., a 16 gauge needle, 17 gauge needle, 18 gauge needle, 19 gauge needle, 20 gauge needle, 21 gauge needle, 22 gauge needle, 23 gauge needle, 24 gauge needle, 25 gauge needle, 26 gauge needle, 27 gauge needle, 28 gauge needle, 29 gauge needle, or a 30 gauge needle.", "In some embodiments, the tri-component matrix is injected with a 22 gauge needle.", "In some embodiments, the tri-component matrix is injected with a 25 gauge needle.", "EXAMPLES Example 1 Production of Tri-Component Matrix Comprising Chondrocytes An exemplary method of manufacturing the tri-component matrix is as follows.", "First, Bovine type II collagen was dissolved in 0.01 M acetic acid.", "Bovine Type II collagen (10 mg) was dissolved in in 2.4 ml 10 mM acetic acid 0/N.", "300 μl of 10 X Medium 199 and 300 μl NaHCO3/HEPES were added to the collagen/acetic acid mixture to neutralize.", "330 μl of hyaluronic acid (HA at 10 mg/ml) (final concentration of 1 mg/ml) was added to the mixture.", "60 μl of chondrotin sulfate (50 mg/ml, Bovine) was added to the mixture to a final concentration of 1 mg/ml to form the tri-component matrix.", "Chondrocytes were then added to the tri-component matrix.", "Example 2 Treatment of Osteochondral Defects with Chondroprogenitors Embedded in Alginate Using a surgical drill, 3-mm osteochondral defects were created in rabbit femoral trochlea grooves and condyles.", "The defects were repaired using two different treatments.", "As a control, nothing was implanted into one defect site.", "In the first treatment adult human chondrocyte derived chondroprogenitor cell pellets were embedded in alginate and then surgically implanted into the defect site.", "In the second treatment H9-derived chondroprogenitor cell pellets were embedded in alginate and then surgically implanted into the defect site.", "Alginate was cross linked in the defect site using surgical gauze soaked with calcium chloride.", "Histologic examination (FIG.", "4) indicated that tissue repair generated by chondroprogenitors embedded in alginate was inferior to that generated by adult human chondrocyte derived chondroprogenitors embedded in alginate.", "However, both were superior to defects implanted with nothing.", "Example 3 Treatment of Osteochondral Defects with Chondroprogenitors Embedded in Matrigel Using a surgical drill, 3-mm osteochondral defects were created in rabbit femoral trochlea grooves and condyles.", "The defects were repaired using four different treatments.", "As a control, nothing was implanted into one defect site.", "In the first treatment, as a control Matrigel alone was surgically implanted into the defect site.", "In the second treatment adult human chondrocyte derived chondroprogenitor cell pellets from donor #1 were embedded in Matrigel and then surgically implanted into the defect site.", "In the third treatment adult human chondrocyte derived chondroprogenitor cell pellets from donor #2 were embedded in Matrigel and then surgically implanted into the defect site.", "In the fourth treatment H9-derived chondroprogenitor cell pellets were embedded in Matrigel and then surgically implanted into the defect site.", "Matrigel (BD Biosciences) was maintained as a liquid at 4 degrees Celsius and after implantation became gelatinous at 37 degrees Celsius.", "Histologic examination (FIG.", "1) indicated that tissue repair generated by H9-derived chondroprogenitors embedded in Matrigel was comparable to that generated by adult human chondrocyte derived chondroprogenitors embedded in Matrigel.", "However, both treatments were superior to defects implanted with nothing or with Matrigel alone.", "Example 4 Treatment of Osteochondral Defects with Chondroprogenitors Embedded in Tri-Component Matrix Using a surgical drill, 3-mm osteochondral defects were created in rabbit femoral trochlea grooves and condyles.", "The defects were repaired using four different treatments.", "In all four treatments (adult human chondrocytes, H9 derives MSCs, iPSC derived from chondrocytes, and adult human MSCs) a tri-component matrix composed of collagen II, chondroitin sulfate, and hyaluronic acid was used.", "The following protocol was used to assemble the tri-component matrix: 1) Bovine type II collagen (Innovative Research) was dissolved in 0.01 M acetic acid (add 10 mg of bovine type II collagen to 2.4 ml of 10 mM acetic acid, 300 μl of 10× Medium 199, and 300 μl of NaHCO3/HEPES to neutralize the acetic acid); 2) 300 μg of hyaluronic acid was added at a concentration of 1 mg/ml; 3) 60 μg of chondrotin sulfate (bovine) was added at a concentration of 1 mg/ml; 4) The final concentration of the type II collagen is approximately 3 mg/ml.", "Histologic examination (FIG.", "2) indicated that tissue repair generated by H9-derived chondroprogenitors embedded in the tri-component matrix was better at tissue regeneration and had better mechanical properties (FIG.", "3) than adult human chondrocyte derived chondroprogenitors, pluripotent cell-derived chondroprogenitors, and adult human mesenchymal stem cells.", "Example 5 Clinical Study of Using Tri-Component Matrix in Treatment of Osteoarthritis Patients are given a single 5 mL injection of the tri-component matrix with chondrocytes (or a phosphate buffered saline control) into the synovial, with a possible repeat treatment after the week 16 visit.", "Study Type: Interventional Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Outcomes Assessor) Primary Purpose: Treatment Outcome Measures: Participants' assessment of pain.", "Mean scores were used for baseline (day 0) and for all visits up to week 16 (weeks 2, 4, 8, 12 and 16).", "The WOMAC Pain Subscale has a score range of 0-4, where 0=no pain and 4=extreme pain.", "Participants categorized the pain they felt while walking using the WOMAC LK 3.1 A1 (Walking Pain) Subscale.", "The scale rates pain as none, mild, moderate, severe and extreme.", "The change from baseline over the course of the 16-week initial treatment period using participants' assessment of physical function.", "Mean scores were used for baseline (day 0) and for all visits up to week 26 (weeks 4, 8, 12, 18 and 26).", "The WOMAC Function Subscale has a score range of 0-4 to assess the degree of difficulty completing tasks within the past 48 hours, where 0=no difficulty and 4=extreme difficulty.", "Ages Eligible for Study: 40 Years and older Genders Eligible for Study: Both Accepts Healthy Volunteers: No Inclusion Criteria: Patient with documented diagnosis of primary osteoarthritis (OA) of the target knee made at least 3 months prior to trial.", "Has radiographic evidence of OA in the tibio-femoral compartment of the target, knee with at least 1 definite osteophyte and a measureable joint space, as diagnosed by standard X-rays taken not longer than 3 months prior to Screening, and before any baseline assessment.", "Has continued target knee pain despite conservative treatment (e.g.", "weight reduction, physical therapy, analgesics).", "Has pain in the target knee as demonstrated by a score of 2 or 3 on the Western Ontario and McMaster Universities Osteoarthritis Index Likert Scale Version 3.1 (WOMAC LK 3.1) A1 (Walking Pain) Subscale.", "Has a mean score of 1.5 to 3.5 on the Western Ontario and McMaster Universities Osteoarthritis Index Likert Scale Version 3.1 (WOMAC LK 3.1) A (Pain) Subscale.", "Inclusion Criteria for Repeat Phase: Must have no major safety concerns during the first course of treatment as assessed by the Investigator; Must have a WOMAC LK 3.1 A score of at least 1.Exclusion Criteria Has modified Kellgren-Lawrence Numerical Grading System of grade IV in the patello-femoral compartment of the target knee confirmed by standard X-rays taken not longer than 3 months prior to Screening, and before any baseline assessment.", "Has clinically apparent tense effusion of the target knee.", "Has had viscosupplementation in any joint including the target knee within 9 months prior to Screening.", "Has concomitant inflammatory disease or other condition that affects the joints (e.g.", "rheumatoid arthritis, metabolic bone disease, psoriasis, gout, symptomatic chondrocalcinosis and active infection, etc.).", "Symptomatic OA of the contralateral knee or of either hip that is not responsive to paracetamol and requires other therapy.", "Has related hypersensitivities to avian proteins and/or any components of hyaluronan-based injection devices.", "Example 6 Treatment of Osteoarthritis with Tri-Component Matrix comprising Chondrocytes A patient presents with osteoarthritis in his knees.", "The calcified cartilage is removed from both knees.", "The surgeon creates fractures in the subchondral bone.", "The tri-component matrix with chondrocytes is injected into the knee.", "The patient returns to the doctor 4 weeks, 8 weeks, and 16 weeks later for an injection of the tri-component matrix with chondrocytes into both knees.", "The cartilage in the knees regenerates.", "While preferred embodiments of the present invention have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only.", "Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the invention.", "It should be understood that various alternatives to the embodiments of the invention described herein may be employed in practicing the invention.", "It is intended that the following claims define the scope of the invention and that methods and structures within the scope of these claims and their equivalents be covered thereby." ] ]
Patent_15872667
[ [ "VIDEO PROVIDING APPARATUS, VIDEO PROVIDING METHOD, AND COMPUTER PROGRAM", "A method for providing a video to a viewer terminal through a communication network includes: receiving, by a communication unit, an original video signal including information of an original video; generating, by a controller, a delayed video signal including information of a delayed video in which the original video is delayed by a first time period; transmitting, by the communication unit, the original video signal to a subtitler terminal; receiving, by the communication unit from the subtitler terminal, a subtitle signal including information of subtitles with respect to the original video and a subtitle delay signal including information for delaying a display of the subtitles; generating, by the controller, a display timing signal indicating a timing of displaying the subtitles on the delayed video, based on the subtitle delay signal; transmitting, by the communication unit, the delayed video signal to a viewer terminal; and transmitting, by the communication unit, the display timing signal and the subtitle signal to the viewer terminal." ], [ "1.A video providing method for providing a video to a viewer terminal through a communication network, comprising: receiving, by a communication unit, an original video signal comprising information of an original video; generating, by a controller, a delayed video signal comprising information of a delayed video in which the original video is delayed by a first time period; transmitting, by the communication unit, the original video signal to a subtitler terminal; receiving, by the communication unit from the subtitler terminal, a subtitle signal comprising information of subtitles with respect to the original video and a subtitle delay signal comprising information for delaying a display of the subtitles; generating, by the controller, a display timing signal indicating a timing of displaying the subtitles on the delayed video, based on the subtitle delay signal; transmitting, by the communication unit, the delayed video signal to the viewer terminal; and transmitting, by the communication unit, the display timing signal and the subtitle signal to the viewer terminal.", "2.The video providing method of claim 1, wherein the subtitle delay signal is a signal comprising information of a second time period for delaying the display of the subtitles, and the generating of the display timing signal further comprises calculating, by the controller, a first timing in which a time obtained by subtracting the second time period from the first time period is delayed from a timing when the subtitler terminal transmitted the subtitle signal, and generating the display timing signal such that the subtitles are displayed on the delayed video at the first timing.", "3.The video providing method of claim 1, wherein the subtitle delay signal is a signal comprising information of a second time period for delaying the display of the subtitles, the receiving of the subtitle delay signal further comprises receiving, by the communication unit, an input start timing signal indicating an input start timing when the subtitles start to be input on the subtitler terminal, and the generating of the display timing signal further comprises calculating, by the controller, a second timing in which a time obtained by subtracting the second time period from the first time period is delayed from the input start timing, and generating the display timing signal such that the subtitles are displayed on the delayed video at the second timing.", "4.The video providing method of claim 1, wherein the subtitle delay signal is a signal comprising information of a feature of the subtitles, and the generating of the display timing signal further comprises generating, by the controller, the display timing signal by determining a timing of displaying the subtitles based on the feature of the subtitles.", "5.The video providing method of claim 1, wherein the transmitting of the subtitle signal to the viewer terminal further comprises transmitting, by the communication unit, a maintaining time signal comprising information of a display maintaining time for maintaining the display of the subtitles to the viewer terminal.", "6.The video providing method of claim 5, wherein the receiving of the subtitle delay signal further comprises receiving, by the communication unit, the maintaining time signal from the subtitler terminal.", "7.The video providing method of claim 5, further comprising, before the transmitting of the subtitle signal to the viewer terminal, determining, by the controller, the display maintaining time based on a feature of the subtitles, and generating the maintaining time signal comprising information of the display maintaining time.", "8.The video providing method of claim 1, wherein the transmitting of the subtitle signal to the viewer terminal further comprises transmitting, by the communication unit, a display location signal comprising information about a location where the subtitles are to be displayed, to the viewer terminal.", "9.The video providing method of claim 8, further comprising, before the transmitting of the subtitle signal to the viewer terminal, generating, by the controller, the display location signal by determining the location where the subtitles are to be displayed in response to the subtitler terminal that transmitted the subtitle signal.", "10.The video providing method of claim 8, wherein the receiving of the subtitle delay signal further comprises receiving, by the communication unit, the display location signal from the subtitler terminal.", "11.The video providing method of claim 1, wherein the transmitting of the original video signal further comprises transmitting, by the communication unit, the original video signal to a first subtitler terminal and a second subtitler terminal, the receiving of the subtitle delay signal further comprises receiving, by the communication unit, a first subtitle signal comprising information of first subtitles from the first subtitler terminal and a second subtitle signal comprising information of second subtitles from the second subtitler terminal, and the transmitting of the subtitle signal further comprises transmitting, by the communication unit, at least one of the first subtitle signal and the second subtitle signal to the viewer terminal.", "12.The video providing method of claim 11, wherein the transmitting of at least one of the first subtitle signal and the second subtitle signal further comprises transmitting, by the communication unit, at least one of the first subtitle signal and the second subtitle signal to the viewer terminal based on at least one of an attribute of the viewer terminal, a request from the viewer terminal, and a request of a video provider terminal that transmitted the original video signal.", "13.The video providing method of claim 11, wherein the transmitting of the subtitle signal further comprises: transmitting, by the communication unit, a first subtitle font signal indicating to display the first subtitles in a first text size, a first text color, or a first font, together with the first subtitle signal; and transmitting, by the communication unit, a second subtitle font signal indicating to display the second subtitles in a second text size, a second text color, or a second font, together with the second subtitle signal.", "14.The video providing method of claim 1, further comprising, after the transmitting of the subtitle signal, receiving, by the communication unit, a feedback signal comprising information of feedback with respect to the subtitles from the viewer terminal.", "15.The video providing method of claim 14, further comprising, after the receiving of the feedback signal, transmitting, by the communication unit, the feedback signal to the subtitler terminal.", "16.A subtitle providing method for providing a subtitle to a server through a communication network, comprising: receiving, by a communication unit, an original video signal comprising information of an original video from the server; outputting, by an output unit, the original video to a user; receiving, by an input unit, subtitles with respect to the original video from the user; generating, by a controller, a subtitle signal comprising information of the subtitles with respect to the original video, and generating a subtitle delay signal comprising information for delaying a display of the subtitles; and transmitting, by the communication unit, the subtitle signal and the subtitle delay signal to the server.", "17.The subtitle providing method of claim 16, wherein the receiving of the subtitles further comprises receiving, by the input unit, a request to delay the display of the subtitles by a second time period, and the generating of the subtitle delay signal further comprises inserting information about the second time period to the subtitle delay signal.", "18.A non-transitory computer-readable recording medium storing a computer program for providing video to a viewer terminal through a communication network, the computer program when executed by a computer performing the steps comprising: receiving, by a communication unit, an original video signal comprising information of an original video; generating, by a controller, a delayed video signal comprising information of a delayed video in which the original video is delayed by a first time period; transmitting, by the communication unit, the original video signal to a subtitler terminal; receiving, by the communication unit from the subtitler terminal, a subtitle signal comprising information of subtitles with respect to the original video and a subtitle delay signal comprising information for delaying a display of the subtitles; generating, by the controller, a display timing signal indicating a timing of displaying the subtitles on the delayed video, based on the subtitle delay signal; transmitting, by the communication unit, the delayed video signal to a viewer terminal; and transmitting, by the communication unit, the display timing signal and the subtitle signal to the viewer terminal.", "19.A video providing apparatus for providing a video to a viewer terminal through a communication network, comprising: a communication unit configured to receive an original video signal comprising information of an original video, transmit the original video signal to a subtitler terminal, and receive, from the subtitler terminal, a subtitle signal comprising information of subtitles with respect to the original video and a subtitle delay signal comprising information for delaying a display of the subtitles; and a controller configured to generate a delayed video signal comprising information of a delayed video in which the original video is delayed by a first time period, and generate a display timing signal indicating a timing when the subtitles are to be displayed on the delayed video based on the subtitle delay signal, wherein the communication unit is further configured to transmit the delayed video signal, the display timing signal, and the subtitle signal to the viewer terminal.", "20.The video providing apparatus of claim 19, wherein the subtitle delay signal is a signal comprising information of a second time period for delaying the display of the subtitles, and the controller is further configured to calculate a first timing in which a time obtained by subtracting the second time period from the first time period is delayed from a timing when the subtitler terminal transmitted the subtitle signal, and generate the display timing signal such that the subtitles are displayed on the delayed video at the first timing." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>Provided are a video providing apparatus, a video providing method, and a computer program, wherein an original video is provided to a viewer terminal by delaying the original video by a certain time, and subtitles are provided to the viewer terminal by receiving the subtitles from a subtitler terminal during the delayed time.", "Provided are a video providing apparatus, a video providing method, and a computer program, wherein information about a timing of displaying subtitles is provided to the viewer terminal together with the subtitles such that the subtitles are displayed at the right timing on a video provided to the viewer terminal.", "According to an aspect of an embodiment, a video providing method includes: receiving, by a communication unit, an original video signal including information of an original video; generating, by a controller, a delayed video signal including information of a delayed video in which the original video is delayed by a first time period; transmitting, by the communication unit, the original video signal to a subtitler terminal; receiving, by the communication unit from the subtitler terminal, a subtitle signal including information of subtitles with respect to the original video and a delay signal including information for delaying a display of the subtitles; generating, by the controller, a display timing signal indicating a timing of displaying the subtitles on the delayed video, based on the subtitle delay signal; transmitting, by the communication unit, the delayed video signal to a viewer terminal; and transmitting, by the communication unit, the display timing signal and the subtitle signal to the viewer terminal.", "According to an aspect of another embodiment, a video providing method includes: receiving, by a communication unit, an original video signal including information of an original video from a server; outputting, by an output unit, the original video; receiving, by an input unit, subtitles with respect to the original video; generating, by a controller, a subtitle signal comprising information of the subtitles with respect to the original video, and generating a delay signal including information for delaying a display of the subtitles; and transmitting, by the communication unit, the subtitle signal and the subtitle delay signal to the server.", "These general and specific embodiments may be implemented by using a system, a method, a computer program, or a combination of the system, the method, and the computer program.", "According to an aspect of another embodiment, a video providing apparatus includes: a communication unit configured to receive an original video signal including information of an original video, transmit the original video signal to a subtitler terminal, and receive, from the subtitler terminal, a subtitle signal including information of subtitles with respect to the original video and a delay signal including information for delaying a display of the subtitles; and a controller configured to generate a delayed video signal including information of a delayed video in which the original video is delayed by a first time period, and generate a display timing signal indicating a timing when the subtitles are to be displayed on the delayed video based on the subtitle delay signal, wherein the communication unit is further configured to transmit the delayed video signal, the display timing signal, and the subtitle signal to a viewer terminal.", "These and/or other aspects will become apparent and more readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings.", "According to the present disclosure, a video providing apparatus, a video providing method, and a computer program may provide an original video to a viewer terminal by delaying the original video by a certain time, and provide subtitles to the viewer terminal by receiving the subtitles from a subtitler terminal during the delayed time.", "Also, a video providing apparatus, a video providing method, and a computer program may provide information about the timing of displaying subtitles to the viewer terminal together with the subtitles such that the subtitles are displayed at the right timing on a video provided to the viewer terminal." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of International Application No.", "PCT/KR2016/006099, filed Jun.", "9, 2016, which claims benefit of Korean Patent Application No.", "10-2015-0101106, filed Jul.", "16, 2015, the entire content of which is incorporated herein by reference.", "BACKGROUND OF THE INVENTION Field of the Invention Embodiments of the present disclosure relate to a video providing apparatus, a video providing method, and a computer program.", "Description of Related Art According to the development of image processing techniques and electronic communication techniques, people who wish to provide a video are now able to broadcast through a communication network, such as the Internet, by using an electronic apparatus, and people who wish to watch a video are also now able to watch the video through the communication network.", "However, most videos include dialogue or text using a particular language, and only a person who understands the particular language can fully enjoy the videos.", "In a video that is already produced, subtitles that are made later may be added to and reproduced together with the video, but it is difficult to provide subtitles for a video broadcasted live.", "Information disclosed in this background section was already known to the inventors before achieving the inventive concept or is technical information acquired in the process of achieving the inventive concept.", "Therefore, it may contain information that does not form the prior art that is already known to the public in this country.", "SUMMARY OF THE INVENTION Provided are a video providing apparatus, a video providing method, and a computer program, wherein an original video is provided to a viewer terminal by delaying the original video by a certain time, and subtitles are provided to the viewer terminal by receiving the subtitles from a subtitler terminal during the delayed time.", "Provided are a video providing apparatus, a video providing method, and a computer program, wherein information about a timing of displaying subtitles is provided to the viewer terminal together with the subtitles such that the subtitles are displayed at the right timing on a video provided to the viewer terminal.", "According to an aspect of an embodiment, a video providing method includes: receiving, by a communication unit, an original video signal including information of an original video; generating, by a controller, a delayed video signal including information of a delayed video in which the original video is delayed by a first time period; transmitting, by the communication unit, the original video signal to a subtitler terminal; receiving, by the communication unit from the subtitler terminal, a subtitle signal including information of subtitles with respect to the original video and a delay signal including information for delaying a display of the subtitles; generating, by the controller, a display timing signal indicating a timing of displaying the subtitles on the delayed video, based on the subtitle delay signal; transmitting, by the communication unit, the delayed video signal to a viewer terminal; and transmitting, by the communication unit, the display timing signal and the subtitle signal to the viewer terminal.", "According to an aspect of another embodiment, a video providing method includes: receiving, by a communication unit, an original video signal including information of an original video from a server; outputting, by an output unit, the original video; receiving, by an input unit, subtitles with respect to the original video; generating, by a controller, a subtitle signal comprising information of the subtitles with respect to the original video, and generating a delay signal including information for delaying a display of the subtitles; and transmitting, by the communication unit, the subtitle signal and the subtitle delay signal to the server.", "These general and specific embodiments may be implemented by using a system, a method, a computer program, or a combination of the system, the method, and the computer program.", "According to an aspect of another embodiment, a video providing apparatus includes: a communication unit configured to receive an original video signal including information of an original video, transmit the original video signal to a subtitler terminal, and receive, from the subtitler terminal, a subtitle signal including information of subtitles with respect to the original video and a delay signal including information for delaying a display of the subtitles; and a controller configured to generate a delayed video signal including information of a delayed video in which the original video is delayed by a first time period, and generate a display timing signal indicating a timing when the subtitles are to be displayed on the delayed video based on the subtitle delay signal, wherein the communication unit is further configured to transmit the delayed video signal, the display timing signal, and the subtitle signal to a viewer terminal.", "These and/or other aspects will become apparent and more readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings.", "According to the present disclosure, a video providing apparatus, a video providing method, and a computer program may provide an original video to a viewer terminal by delaying the original video by a certain time, and provide subtitles to the viewer terminal by receiving the subtitles from a subtitler terminal during the delayed time.", "Also, a video providing apparatus, a video providing method, and a computer program may provide information about the timing of displaying subtitles to the viewer terminal together with the subtitles such that the subtitles are displayed at the right timing on a video provided to the viewer terminal.", "DESCRIPTION OF THE DRAWINGS FIG.", "1 is a diagram schematically illustrating a configuration of a video providing system according to an embodiment of the present disclosure.", "FIG.", "2 is a block diagram schematically illustrating an example of an internal configuration of a video providing apparatus of FIG.", "1.FIGS.", "3 and 4 are block diagrams schematically illustrating examples of an internal configuration of a subtitler terminal, according to an embodiment of the present disclosure.", "FIGS.", "5 through 21 are flowcharts schematically illustrating examples of a video providing method according to various embodiments of the present disclosure.", "DETAILED DESCRIPTION OF THE INVENTION Reference will now be made in detail to embodiments, examples of which are illustrated in the accompanying drawings.", "In this regard, the present embodiments may have different forms and should not be construed as being limited to the descriptions set forth herein.", "Accordingly, the embodiments are merely described below, by referring to the figures, to explain aspects of the present description.", "In drawings, like reference numerals refer to like elements throughout and overlapping descriptions shall not be repeated.", "While such terms as “first”, “second”, etc., may be used to describe various components, such components must not be limited to the above terms.", "The above terms are used only to distinguish one component from another.", "An expression used in the singular encompasses the expression of the plural, unless it has a clearly different meaning in the context.", "In the present specification, it is to be understood that terms such as “including” or “having,” etc., are intended to indicate the existence of features or components, and are not intended to preclude the possibility that one or more other features or components may exist or may be added.", "In the drawings, for convenience of description, sizes of components may be exaggerated for clarity.", "For example, since sizes and thicknesses of components in drawings are arbitrarily shown for convenience of description, the sizes and thicknesses are not limited thereto.", "A video in the present specification may include audiovisual information.", "In other words, the video may include information of sound (for example, voice) generated by a real person, a virtual character, a surrounding object, or a background appearing in the video.", "Examples of the video may include a movie, news, a drama series, and an animation, and may also include various types of personal broadcasts provided through a communication network, such as the Internet.", "In the present specification, the video may include a still image displayed throughout a certain period of time.", "Also, subtitles in the present specification may be symbols indicating, in visual forms, various audiovisual types of information expressed in a video.", "For example, various types of information expressed in a video may include sound generated by a real person, a virtual character, a surrounding object, or a background appearing in the video, and may also include information of movement, a shape, a color, a smell, or narration.", "The subtitles may be visual symbols including characters, punctuation marks, figures, drawings, or photographs indicating such information.", "In addition, despite the name, the subtitles in the present specification may be sound indicating, in an auditory form, various audiovisual types of information expressed in a video.", "For example, when a character or narrator appearing in a video speaks lines in a first language, voice in which the lines are translated into a second language may be the subtitles.", "Here, the voice in the second language may be voice of an ordinary citizen performing translation or voice generated by a voice generating program.", "FIG.", "1 is a diagram schematically illustrating a configuration of a video providing system according to an embodiment of the present disclosure.", "Referring to FIG.", "1, a video providing system 10 according to an embodiment includes a video providing apparatus 100.Also, the video providing system 10 further includes a video supplier terminal 200, a subtitler terminal 300, a viewer terminal 400, and a communication network 500.The video providing system 10 according to an embodiment of the present disclosure provides a video supplied from the video supplier terminal 200 to the viewer terminal 400.Also, subtitles generated from the subtitler terminal 300 are provided to the viewer terminal 400.The video providing apparatus 100 is an apparatus for performing a video providing service of the video providing system 10.In other words, the video providing apparatus 100 may receive a video signal including information of a video supplied from the video supplier terminal 200.Also, the video providing apparatus 100 may provide the video signal to the subtitler terminal 300 so as to provide, to a user of the subtitler terminal 300, an opportunity to input subtitles with respect to the video.", "Also, the video providing apparatus 100 may receive a subtitle signal including information of the subtitles from the subtitler terminal 300.The video providing apparatus 100 may provide, to the viewer terminal 400, various signals enabling the viewer terminal 400 to reproduce the video and the subtitles with respect to the video.", "The video providing apparatus 100 may be a server in which data (for example, the video and the subtitles) for performing the video providing service is stored.", "Here, the video providing apparatus 100 may include a plurality of servers based on traffic or an amount of data.", "The video providing apparatus 100 may be a server that provides not only the video providing service, but also a general search service and other various services enhancing user convenience.", "In other words, the video providing apparatus 100 may provide, in addition to the video providing service, various services, such as a search service, an email service, a blog service, a social network service, a news service, and shopping information providing service.", "Alternatively, the video providing apparatus 100 may be a server providing, to a terminal requesting the portal service to provide information, a web page provided by the portal service, by being connected to a server providing the portal service, such as a search service, an email service, a news service, or a shopping service.", "Here, the video providing apparatus 100 and the server providing the portal service may be separate servers physically separated from each other or may be one server only conceptually separated.", "The video providing apparatus 100 includes a communication unit 110 and a controller 120.The communication unit 110 may receive a signal related to a video desired to be supplied by the video supplier terminal 200.Also, the communication unit 110 may provide the signal related to the video to the subtitler terminal 300, or receive a subtitle signal with respect to the video from the subtitler terminal 300.Also, the communication unit 110 may provide the signal related to the video and the subtitle signal to the viewer terminal 400.Such a communication unit 110 may be a Bluetooth communication unit, a Bluetooth low energy (BLE) communication unit, a near field communication unit, a wireless local area network (WLAN) (Wi-Fi) communication unit, a Zigbee communication unit, an infrared data association (IrDA) communication unit, a Wi-Fi direct (WFD) communication unit, an ultra wideband (UWB) communication unit, or an Ant+ communication unit, but is not limited thereto.", "The controller 120 generally controls the overall operations of the video providing apparatus 100.For example, the controller 120 may allow or prohibit signal transmission and reception of the communication unit 110 by controlling signal transmission and reception operations of the communication unit 110.The controller 120 may include any type of apparatus capable of processing data, such as a processor.", "Here, the ‘processor’ may denote, for example, a data processing apparatus embedded in hardware and having a physically structured circuit to perform a function expressed in a code or command included in a program.", "Examples of the data processing apparatus embedded in hardware may include a microprocessor, a central processing unit (CPU), a processor core, a multiprocessor, an application specific integrated circuit (ASIC), and a field programmable gate array (FPGA), but are not limited thereto.", "Referring to FIG.", "2, the video providing apparatus 100 may further include, in addition to the communication unit 110 and the controller 120, a memory 130, a program storage unit 140, and a database (DB) 150.The memory 130 may temporarily or permanently store data processed by the controller 120.Here, the memory 130 may include a magnetic storage medium or a flash storage medium, but the range of the present disclosure is not limited thereto.", "The program storage unit 140 may be a component including software for performing various essential or auxiliary operations so as to perform the video providing service.", "The DB 150 may store data received from the video supplier terminal 200, the subtitler terminal 300, the viewer terminal 400, or another electronic apparatus.", "The communication unit 110 may receive a signal including information of particular data from the video supplier terminal 200, the subtitler terminal 300, or the viewer terminal 400, and the DB 150 may store the data.", "Also, the communication unit 110 may receive a request signal requesting particular data from the video supplier terminal 200, the subtitler terminal 300, or the viewer terminal 400, and the controller 120 may select data corresponding to the request signal from data stored in the DB 150.The communication unit 110 may provide the selected data to an electronic apparatus that transmitted the request signal.", "Referring back to FIG.", "1, the video supplier terminal 200 may be an apparatus supplying the video in the video providing system 10.Here, the video supplied by the video supplier terminal 200 may be a video directly manufactured by the video supplier terminal 200 or a video received by the video supplier terminal 200 from an external source.", "The video signal including information of the video supplied by the video supplier terminal 200 may be transmitted to the video providing apparatus 100 through the communication network 500.The subtitler terminal 300 may generate the subtitles with respect to the video supplied by the video supplier terminal 200.Here, the subtitles generated by the subtitler terminal 300 may be subtitles input by a user of the subtitler terminal 300.Alternatively, the subtitles generated by the subtitler terminal 300 may be subtitles automatically generated by an automatic translation computer program or a voice recognition computer program inside or outside the subtitler terminal 300.A plurality of the subtitler terminal 300 may be included in one video providing system 10.In other words, one video providing system 10 may include a first subtitler terminal 300a and a second subtitler terminal 300b, and each of the subtitler terminals 300 may generate subtitles with respect to one video.", "The viewer terminal 400 may be an apparatus displaying the video supplied by the video supplier terminal 200 and the subtitles generated by the subtitler terminal 300.In other words, the viewer terminal 400 may receive the video signal including the information of the video and the subtitle signal including the information of the subtitles, and may provide the video and the subtitles to a user of the viewer terminal 400 by using the signals.", "A plurality of the viewer terminals 400 may be included in one video providing system 10.In other words, one video providing system 10 may include a first viewer terminal 400a and a second viewer terminal 400b, and the viewer terminals 400 may reproduce the same or different videos, and may reproduce the same or different subtitles with respect to the same video.", "Here, the subtitles displayed in the viewer terminal 400 may be characters prepared in visual symbols, or as described above, may be sound expressed in an auditory form.", "In other words, when the subtitle signal including voice information is generated by the subtitler terminal 300, the viewer terminal 400 may receive the signal from the video providing apparatus 100 and output corresponding voice through a sound unit of the viewer terminal 400.Here, the sound expressed in the auditory form may be voice dubbed by the user of the subtitler terminal 300.An electronic apparatus capable of transmitting and receiving data to and from another apparatus in a wired/wireless communication environment may be unlimitedly employed as the video supplier terminal 200, the subtitler terminal 300, or the viewer terminal 400.In detail, each of the video supplier terminal 200, the subtitler terminal 300, and the viewer terminal 40 may be a desktop computer, a notebook personal computer (PC), a tablet PC, a smart phone, a smart television (TV), a mobile phone, a personal digital assistant (PDA), a laptop computer, a media player, a micro-server, a global positioning system (GPS) apparatus, an electronic book terminal, a digital broadcasting terminal, a navigation device, a kiosk, an MP3 player, a digital camera, a wearable device, or another mobile or non-mobile computing apparatus, but is not limited thereto.", "Also, each of the video supplier terminal 200, the subtitler terminal 300, and the viewer terminal 400 may include various apparatuses capable of receiving a touch input, such as an electronic blackboard and a touch table, and may be an accessory, such as a watch, glasses, a hair band, or a ring, having a communication function or a data processing function, but is not limited thereto.", "The communication network 500 may electrically connect the video providing apparatus 100 to each of the video supplier terminal 200, the subtitler terminal 300, and the viewer terminal 400.In other words, the communication network 500 may denote a connection path between electronic apparatuses capable of transmitting and receiving data to and from another apparatus in a wired/wireless communication environment.", "Examples of the communication network 500 may include wired networks, such as a local area network (LAN), a wide area network (WAN), a metropolitan area network (MAN), and an integrated service digital network (ISDN), and wireless networks, such as wireless LAN, a code division multiple access (CDMA), Bluetooth, and a satellite communication network, but are not limited thereto.", "FIGS.", "3 and 4 are block diagrams schematically illustrating examples of an internal configuration of a subtitler terminal, according to an embodiment of the present disclosure.", "Referring to FIG.", "3, the subtitler terminal 300 according to an embodiment of the present disclosure includes a communication unit 310, an input unit 320, an output unit 330, and a controller 340.The communication unit 310 may receive the signal related to a video from the video providing apparatus 100.Also, the communication unit 310 may provide a subtitle signal including the information of the subtitles to the video providing apparatus 100.The communication unit 310 may be a Bluetooth communication unit, a BLE communication unit, a near field communication unit, a WLAN communication unit, a Zigbee communication unit, an IrDA communication unit, a WFD communication unit, an UWB communication unit, or an Ant+ communication unit, but is not limited thereto.", "The input unit 320 may receive various requests from the user of the subtitler terminal 300.For example, the input unit 320 may receive a request for receiving a video from the user of the subtitler terminal 300, a request for reproducing the received video, and a request for transmitting a subtitle signal.", "Also, the input unit 320 may receive the subtitle information input by the user of the subtitler terminal 300.The input unit 320 may receive a voice input of the user, a character input of the user, an input of the user pressing a button, or a touch input of the user, but the range of the present disclosure is not limited thereto.", "The output unit 330 may output a signal for transmitting information to the user of the subtitler terminal 300 in various forms.", "For example, the output unit 330 may audiovisually output image information and information about sound of the received video.", "Referring to FIG.", "4, the output unit 330 may include a display unit 331 and a sound unit 332.Also, the subtitler terminal 300 may further include, in addition to the communication unit 310, the input unit 320, the output unit 330, and the controller 340, a memory 350 and a program storage unit 360.The display unit 331 may display information intended to be displayed visually from among information included in the video signal.", "For example, the display unit 331 may output image information included in the video signal to at least a partial region of the display unit 331.The display unit 331 may include at least one of a liquid crystal display, a thin film transistor-liquid crystal display, an organic light-emitting diode, a 3-dimensional (3D) display, and an electrophoretic display, but is not limited thereto.", "According to an embodiment of the subtitler terminal 300, the subtitler terminal 300 may include two or more display units 331.The sound unit 332 may output information intended to be transmitted in an auditory form from among information included in the video signal.", "For example, the sound unit 332 may output information about sound included in the video signal.", "The sound unit 332 may output sound having different lengths, frequencies, volumes, pitches, or tones based on a type of notification.", "The sound unit 332 may include at least one of a tuner, an equalizer, a headphone, an earphone, and various types of speakers, but is not limited thereto.", "In other words, the sound unit 332 may be any type of apparatus capable of generating sound via electrical or mechanical method.", "The memory 350 may perform a function of temporarily or permanently storing data processed by the controller 340.Here, the memory 350 may include a magnetic storage medium or a flash storage medium, but the range of the present disclosure is not limited thereto.", "The program storage unit 360 may be a component including software for performing various essential or auxiliary operations so as to perform the video providing service.", "FIGS.", "5 through 21 are flowcharts schematically illustrating examples of a video providing method according to embodiments of the present disclosure.", "Hereinafter, the video providing method using the video providing apparatus 100 described above will be described with reference to FIGS.", "5 through 19, and a method of providing subtitles of a video using the subtitler terminal 300 described above will be described with reference to FIGS.", "20 and 21.First, referring to FIG.", "5, the video providing apparatus 100 may receive an original video signal in operation S100.Here, the original video signal may include information about an original video and the content of the original video.", "In other words, the original video signal may be a signal including various types of information required to reproduce the original video.", "The various types of information may include, for example, image information about at least some frames from among all frames of the video, sound information about sound output while the video is reproduced, and information about a video codec.", "The video providing apparatus 100 may receive the original video signal from the video supplier terminal 200.The reception of the original video signal is performed by the communication unit 110 of the video providing apparatus 100.Then, the video providing apparatus 100 generates a delayed video signal in operation S200.The delayed video signal may include information about a delayed video.", "Here, the delayed video may be a video in which the transmission of the original video to the viewer terminal 400 is delayed by a first time period.", "The delayed video signal may be a signal newly generated separately from the original video signal or may be a signal provided after the first time period after simply temporarily storing the original video signal.", "In other words, the video providing apparatus 100 generating the delayed video signal may mean that a signal including information of a new video is generated by generating the new video in which a reproduction time of the new video is delayed by the first time period from the receipt of the original video signal, or may mean a delay operation in an operation of simply storing, for the first time period, and delaying the transmission of the original video signal to the viewer terminal 400.Here, the first time period may be a time arbitrarily set by a manager of the video providing apparatus 100 or the user of the video supplier terminal 200.The first time period may be a spare or additional time for the video providing apparatus 100 to provide, to the viewer terminal 400, a video together with subtitles.", "In detail, the first time period may be a spare or additional time spent by the video providing apparatus 100 to transmit the original video signal to the subtitler terminal 300, the time spent by the subtitler terminal 300 to generate the subtitles, and the time spent by the video providing apparatus 100 to receive a subtitle signal from the subtitler terminal 300.The first time period may be set in terms of seconds, minutes, or hours, to allow the video providing apparatus 100 to take the necessary steps to provide the video with subtitles to the viewer terminal 400.The delayed video signal may be generated by the controller 120 of the video providing apparatus 100.Also, the video providing apparatus 100 may transmit the original video signal to the subtitler terminal 300 in operation S300.Here, the video providing apparatus 100 may transmit the original video signal received from the video supplier terminal 200 as it is or after a time shorter than the first time period.", "Alternatively, the video providing apparatus 100 may extract the original video from the original video signal received from the video supplier terminal 200, and newly generate and transmit a signal including the extracted information.", "In other words, resolution, frame per second, and codec of the video according to the original video signal received from the video supplier terminal 200 may be different from or same as resolution, frame per second, and codec of the video according to the original video signal transmitted to the subtitler terminal 300.The original video signal may be transmitted by the communication unit 110 of the video providing apparatus 100.Then, the video providing apparatus 100 may receive the subtitle signal and a subtitle delay signal from the subtitler terminal 300 in operation S400.The subtitle signal may be a signal including information of subtitles generated by the subtitler terminal 300, and the subtitles may be subtitles related content of the original video.", "The subtitle delay signal may be a signal including information for delaying a display of the subtitles.", "In detail, the user of the subtitler terminal 300 may personally prepare subtitles with respect to partial content of the video while personally watching the original video.", "Here, it may take some time for the user of the subtitler terminal 300 to watch the partial content of the video and prepare the subtitles with respect to the partial content.", "For example, when the user hears Korean of ‘’ and prepares English subtitles of ‘hello’, a time for listening ‘’, a time for thinking how to translate ‘’ to English, and a time for typing ‘hello’ may be consumed.", "As a result, when the video providing apparatus 100 displays the subtitles on the video based on a point of time when the subtitle signal is received, an image and the subtitles may not synchronize.", "The subtitle delay signal may include information about delayed times generated by the user of the subtitler terminal 300.The subtitle signal and the subtitle delay signal may be received by the communication unit 110 of the video providing apparatus 100.A detailed example of information included in the subtitle delay signal will be described with reference to FIGS.", "6 and 7.Then, the video providing apparatus 100 may generate a display timing signal in operation S500.The video providing apparatus 100 may generate the display timing signal based on the subtitle delay signal, and such a display timing signal may be a signal indicating a timing when the subtitles are to be displayed on the delayed video.", "In detail, as described above, the subtitle delay signal may be a signal including information about the delayed times generated by the user of the subtitler terminal 300, and the video providing apparatus 100 may determine a timing when the subtitles are to be actually displayed by using the information.", "The display timing signal may be generated by the controller 120 of the video providing apparatus 100.A detailed example of generating the display timing signal will be described with reference to FIGS.", "6 through 8.Meanwhile, the video providing apparatus 100 may transmit the delayed video signal to the viewer terminal 400 in operation S600.The delayed video signal is transmitted by the communication unit 110 of the video providing apparatus 100.Also, the video providing apparatus 100 may transmit the subtitle signal and the display timing signal to the viewer terminal 400 in operation S700.The subtitle signal and the display timing signal are transmitted by the communication unit 110 of the video providing apparatus 100.In operations S600 and S700, the video providing apparatus 100 may enable the viewer terminal 400 to reproduce the video while displaying the subtitles corresponding to the video.", "Here, the video providing apparatus 100 may also provide the display timing signal indicating when the subtitles are to be displayed in the video such that the viewer terminal 400 may display the subtitles at a timing intended by the video providing apparatus 100.In FIG.", "5, operation S300 is performed after operation S200, but the present disclosure is not limited thereto, and operation S300 may be performed before operation S200 or may be performed at the same time as operation S200.Also, an order of performing operations S600 and S700 may be changed or operations S600 and S700 may be performed simultaneously.", "Selectively, according to an embodiment of FIG.", "6, operation S500 of the video providing method may include calculating a first timing and generating the display timing signal (operation S510).", "In detail, the subtitle delay signal received from the subtitler terminal 300 may be signal including information of a second time period.", "The second time period is a time assigned by the user of the subtitler terminal 300, and may indicate a delayed time consumed while the user generates subtitles of content personally viewed.", "In this case, the video providing apparatus 100 may calculate the first timing in which a time obtained by subtracting the second time period from the first time period is delayed from a timing when the subtitler terminal 300 transmitted the subtitle signal or a timing when the video providing apparatus 100 received the subtitle signal transmitted by the subtitler terminal 300.Hereinafter, processes of calculating the first timing will be described in an order of logical operations.", "First, the video providing apparatus 100 may delay the first time period from a timing when the subtitle signal is completed.", "Such an operation may be performed to compensate for the time difference of the video between the subtitler terminal 300 and the viewer terminal 400 since the video provided by the video providing apparatus 100 to the viewer terminal 400 is delayed by the first time period.", "Then, the video providing apparatus 100 may calculate the time advanced by the second time period.", "Such an operation may be performed to compensate for the time difference caused by the delayed time generated while the user of the subtitler terminal 300 generates the subtitles.", "In operation S510, the video providing apparatus 100 may calculate the first timing, i.e., a subtitle display timing for synchronizing the delayed video and the subtitles, and generate the display timing signal indicating the first timing.", "Selectively, according to an embodiment of FIG.", "7, operation S400 of the video providing method may include receiving an input start timing signal (operation S410), and operation S500 may include calculating a second timing and generating the display timing signal (operation S520).", "In detail, the subtitle delay signal received from the subtitler terminal 300 may be a signal including information of the second time period.", "Also, the subtitler terminal 300 may transmit, to the video providing apparatus 100, the input start timing signal including information that the subtitles are started to be input, when the user of the subtitler terminal 300 starts to input the subtitles in the subtitler terminal 300.At this time, the second time period is a time personally assigned by the user of the subtitler terminal 300, and may indicate a delayed time consumed by the user from when the user starts to watch a certain portion of the video to when the user starts to input the subtitles in the subtitler terminal 300.The second time period may be a delayed time consumed while the user generates subtitles of watched content.", "In this case, the video providing apparatus 100 may calculate the second timing in which the time obtained by subtracting the second time period from the first time period is delayed from a timing when the subtitler terminal 300 transmitted the subtitle signal or a timing when the video providing apparatus 100 received the subtitle signal transmitted by the subtitler terminal 300.Hereinafter, processes of calculating the second timing will be described in an order of logical operations.", "First, the video providing apparatus 100 may delay the first time period from a timing when the subtitle signal is completed.", "Such an operation may be performed to compensate for a time difference of the video between the subtitler terminal 300 and the viewer terminal 400 since the video provided by the video providing apparatus 100 to the viewer terminal 400 is delayed by the first time period.", "Then, the video providing apparatus 100 may calculate a time advanced by the second time period.", "Such an operation may be performed to compensate for a time difference caused by the delayed time generated from when the user of the subtitler terminal 300 starts to watch the video to when the user of the subtitler terminal 300 starts to input the subtitles.", "According to operations s410 and S520, the video providing apparatus 100 may calculate the second timing, i.e., a subtitle display timing for synchronizing the delayed video and the subtitles, and may generate the display timing signal indicating the second timing.", "Selectively, according to an embodiment of FIG.", "8, operation S500 of the video providing method may include determining a subtitle display timing based on a feature of the subtitles and generating the display timing signal (operation S530).", "Here, the feature of the subtitles may include the length of subtitles, the language of the subtitles, alphabet included in the subtitles, or a type of words.", "In other words, the video providing apparatus 100 may estimate an estimated time that may be consumed for the user of the subtitler terminal 300 to input the subtitles, based on the feature of the subtitles, such as the length of the subtitles.", "Then, the video providing apparatus 100 may calculate a timing in which a time obtained by subtracting the estimated time from the first time period is delayed from a timing when the subtitler terminal 300 transmits the subtitle signal, a timing when the video providing apparatus 100 received the subtitle signal transmitted from the subtitler terminal 300, or a timing when the subtitles are started to be input on the subtitler terminal 300.According to operation S530, the video providing apparatus 100 may calculate the subtitle display timing for synchronizing the delayed video and the subtitles, and generate the display timing signal indicating the subtitle display timing.", "Selectively, according to an embodiment of FIG.", "9, operation S700 of the video providing method may include transmitting a maintaining time signal to the viewer terminal 400 (operation S710).", "In detail, the maintaining time signal may be a signal including information of a delay maintaining time for maintaining the display of the subtitles.", "In other words, the video providing apparatus 100 may provide, to the viewer terminal 400, a signal indicating how long the subtitles provided to the viewer terminal 400 is to be displayed on the viewer terminal 400.Here, the maintaining time signal may be a signal received by the video providing apparatus 100 from the subtitler terminal 300.In other words, according to an embodiment of FIG.", "10, operation S400 of the video providing method may include receiving the maintaining time signal (operation S420).", "In other words, the user of the subtitler terminal 300 may self-determine how long the subtitles input by him/herself are to be displayed.", "For example, when the subtitles are relatively short, such as ‘hello’, the user of the subtitler terminal 300 may determine a subtitle maintaining time to be relatively short, and when the subtitles are relatively long, the user of the subtitler terminal 300 may determine the subtitle maintaining time to be relatively long.", "The video providing apparatus 100 may receive the maintaining time signal including information of the subtitle maintaining time, and transmit the signal to the viewer terminal 400, together with the subtitle signal.", "Also, the maintaining time signal may be a signal directly generated by the video providing apparatus 100.In other words, according to an embodiment of FIG.", "11, the video providing method may further include, before operation S700, generating the maintaining time signal based on the feature of the subtitles (operation S690).", "Here, the feature of the subtitles may include the length of the subtitles, the language of the subtitles, the alphabet included in the subtitles, and the type of words.", "In other words, the video providing apparatus 100 may predict a time to be consumed by the user of the viewer terminal 400 to read the subtitles while watching the video, based on the feature of the subtitles, such as the length of the subtitles.", "The video providing apparatus 100 may determine the subtitle maintaining time based on the predicted time, generate the maintaining time signal including information of the subtitle maintaining time, and transmit the maintaining time signal to the viewer terminal 400 together with the subtitle signal.", "The maintaining time signal may be generated by the controller 120 of the video providing apparatus 100.According to operation S710, the video providing apparatus 100 may provide, to the viewer terminal 400, information about how long each subtitle is to be displayed on the video.", "The viewer terminal 400 may display each subtitle on a display unit for the subtitle maintaining time according to the maintaining time signal.", "At this time, when a second subtitle needs to be displayed before a subtitle maintaining time of a first subtitle is passed, the viewer terminal 400 may delete the first subtitle early and display the second subtitle, move a location of the first subtitle and display the second subtitle, or display the second subtitle at a location that does not overlap the first subtitle.", "Selectively, according to an embodiment of FIG.", "12, operation S700 of the video providing method may include transmitting a display location signal to the viewer terminal 400 (operation S720).", "In detail, the display location signal may be a signal including information about a location where the subtitles are to be displayed on the display unit of the viewer terminal 400 or on the video.", "For example, the display location signal may be a signal assigning a location such that the subtitles are displayed at a bottom portion of the display unit of the viewer terminal 400, or a signal assigning a location such that the subtitles are displayed in speech bubbles at particular locations of the video.", "In other words, the video providing apparatus 100 may provide, to the viewer terminal 400, the display location signal indicating whether the subtitles provided to the viewer terminal 400 are to be displayed on the viewer terminal 400.Here, the display location signal may be a signal directly generated by the video providing apparatus 100.In other words, according to an embodiment of FIG.", "13, the video providing method may further include, before operation S700, generating the display location signal in response to the subtitler terminal 300 (operation S695).", "Here, the video providing apparatus 100 may determine display locations of the subtitles based on a type of the subtitler terminal 300.For example, when the first subtitler terminal 300a and the second subtitler terminal 300b each transmit subtitles to the video providing apparatus 100, the video providing apparatus 100 may determine a display location of the subtitles received from the first subtitler terminal 300a to be a left portion of the display unit of the viewer terminal 400 and a display location of the subtitles received from the second subtitler terminal 300b to be a right portion of the display unit of the viewer terminal 400.The video providing apparatus 100 may generate the display location signal including information of the subtitle display location, and transmit the display location signal to the viewer terminal 400 together with the subtitle signal.", "The display location signal may be generated by the controller 120 of the video providing apparatus 100.Also, the display location signal may be a signal received by the video providing apparatus 100 from the subtitler terminal 300.In other words, according to an embodiment of FIG.", "14, operation S400 of the video providing method may include receiving the display location signal (operation S430).", "In other words, the user of the subtitler terminal 300 may determine by him/herself where the subtitles input by him/herself are to be displayed on the video.", "For example, when the subtitles are lines of a person sitting on the right side of a scene in the video, the subtitler terminal 300 may determine a display location of the subtitles to be the right side of the scene to indicate who is speaking the lines corresponding to the subtitles.", "The video providing apparatus 100 may receive the display location signal including the information of the subtitle display location, and transmit the display location signal to the viewer terminal 400 together with the subtitle signal.", "According to operation S720, the video providing apparatus 100 may provide, to the viewer terminal 400, information about where each subtitle is to be displayed.", "Selectively, according to an embodiment of FIG.", "15, operation S300 of the video providing method may include transmitting the original video signal to the first and second subtitler terminals 300a and 300b (operation S310), operation S400 may include receiving first and second subtitle signals respectively from the first and second subtitler terminals 300a and 300b (operation S440), and operation S700 may include transmitting at least one of the first and second subtitle signals to the viewer terminal 400.In other words, there may be a plurality of the subtitler terminals 300 that transmit and receive a video signal and a subtitle signal to and from one video providing apparatus 100.Also, the video providing apparatus 100 may transmit at least one of the first and second subtitle signals to the viewer terminal 400.Here, selectively, the video providing apparatus 100 may transmit at least one of the first and second subtitle signals to the viewer terminal 400 while considering various conditions.", "In other words, according to an embodiment of FIG.", "16, operation S730 of the vide providing method may include transmitting at least one of the first and second subtitle signals while considering various conditions (operation S731).", "The various conditions considered by the video providing apparatus 100 may include a request from the viewer terminal 400, nationality information of a location where the viewer terminal 400 exists, language information used in a corresponding country, whether a particular subtitle signal is assigned from the viewer terminal 400, whether reception of a particular subtitle signal is denied by the viewer terminal 400, and a request of the subtitler terminal 300.In other words, for example, when the first viewer terminal 400a is an electronic apparatus in China, the video providing apparatus 100 may transmit only a subtitle signal in Chinese to the first viewer terminal 400a.", "As another example, when the second viewer terminal 400b has denied reception of the first subtitle signal, the video providing apparatus 100 may transmit only the second subtitle signal to the second viewer terminal 400b.", "Here, the video providing apparatus 100 may provide, to the viewer terminal 400, information that may be considered while the viewer terminal 400 assigns or denies a particular subtitle signal.", "Such information may include particular subtitle selection information of another viewer terminal 400, particular subtitle recommendation information of the other viewer terminal 400, particular subtitle recommendation information of the video supplier terminal 200, or information directly provided from the subtitler terminal 300.For example, the video providing apparatus 100 may provide, to the second viewer terminal 400b, information indicating that the first viewer terminal 400a selected the first subtitle signal, information that the first subtitle signal is recommended, or information that the video supplier terminal 200 disapproved the second subtitle signal.", "As another example, the video providing apparatus 100 may provide, to the second viewer terminal 400b, information about the subtitles provided by the subtitler terminal 300 (for example, information indicating that the subtitles may include slangs or information that he/she has prepared the subtitles for the first time).", "The video providing apparatus 100 may transmit a plurality of subtitle signals to the viewer terminal 400, and the viewer terminal 400 may select a particular subtitle signal and display only subtitles included in the signal.", "In addition, the video providing apparatus 100 may block transmission of a particular subtitle signal regardless of a request from the viewer terminal 400, or provide a subtitle signal arbitrarily selected by the viewer terminals 400, based on conditions pre-set in the video providing apparatus 100.Also, selectively, according to an embodiment of FIG.", "17, operation S700 of the video providing method may include transmitting a first subtitle font signal to the viewer terminal 400 (operation S740) and transmitting a second subtitle font signal to the viewer terminal 400 (operation S750).", "In detail, the video providing apparatus 100 may transmit, to the viewer terminal 400, the first subtitle font signal including information for displaying first subtitles in a first text size, a first text color, or a first font, together with the first subtitle signal.", "Similarly, the video providing apparatus 100 may transmit, to the viewer terminal 400, the second subtitle font signal including information for displaying second subtitles in a second text size, a second text color, or a second font, together with the second subtitle signal.", "Generally, the text size, the color, the font, etc.", "of subtitles may be determined by a terminal of a person watching a video, i.e., by the viewer terminal 400.However, the video providing apparatus 100 may transmit a subtitle font signal including information of the font of each of the first and second subtitles to the viewer terminal 400 such that the first subtitles received from the first subtitler terminal 300a and the second subtitles received from the second subtitler terminal 300b are distinguishably displayed on the viewer terminal 400.Here, the first and second subtitle font signals may be signals directly generated by the video providing apparatus 100, or may be signals received respectively from the first and second subtitler terminals 300a and 300b.", "The video providing apparatus 100 may not transmit a separate subtitle font signal to the viewer terminal 400, but the viewer terminal 400 may directly determine and display a font of each subtitle.", "Selectively, according to an embodiment of FIG.", "18, the video providing method may further include, after operation S700, receiving a feedback signal (operation S800).", "In other words, the video providing apparatus 100 may receive a feedback signal from the viewer terminal 400.The feedback signal may include evaluation regarding the provided subtitles.", "In detail, the video providing apparatus 100 may receive, from the viewer terminal 400, a feedback signal including information about various types of feedback, such as feedback indicating that translation of the subtitles is not correct, feedback indicating that the subtitles and the video are not synchronized well, and feedback indicating that the subtitles are satisfactory.", "The feedback signal may be received by the communication unit 110 of the video providing apparatus 100.Also, according to an embodiment of FIG.", "19, the video providing apparatus 100 may transmit the feedback signal to the subtitler terminal 300.In other words, the video providing method may further include, after operation S800, transmitting the feedback signal to the subtitler terminal 300 (operation S900).", "The feedback signal may be transmitted by the communication unit 110 of the video providing apparatus 100.According to operation S800, the video providing apparatus 100 may obtain feedback of viewers with respect to the whole of the current video providing system 10.Also, according to operation S900, the video providing apparatus 100 may provide information about feedback of viewers regarding the subtitles of the subtitler terminal 300 to the user of the subtitler terminal 300.Referring to FIG.", "20, the subtitler terminal 300 may receive the original video signal from the video providing apparatus 100 (operation S1100).", "The original video signal may be received by the communication unit 310 of the subtitler terminal 300.Then, the subtitler terminal 300 may output the original video (operation S1200).", "In other words, the subtitler terminal 300 may reproduce the original video such that the user of the subtitler terminal 300 may personally prepare the subtitles while watching the original video.", "The original video may be output by the output unit 303 of the subtitler terminal 300.Then, the subtitler terminal 300 may receive the subtitles in operation S1300.Here, the user of the subtitler terminal 300 may input the subtitles through an input device, such as a keyword or a touchpad, input the subtitles in voice via a microphone, or select at least some characters from pre-set idioms or pre-prepared subtitles and input the characters as at least some of the subtitles to be input.", "Also, the subtitler terminal 300 may receive the subtitles automatically generated by an automatic translation computer program inside or outside the subtitler terminal 300.In other words, the subtitler terminal 300 may receive subtitles automatically generated by a computer algorithm, instead of subtitles directly input by the user of the subtitler terminal 300, who is a natural person.", "Also, despite the expression ‘the subtitles are received’, the subtitler terminal 300 may automatically generate the subtitles by using an automatic translation computer program or a voice recognition computer program installed in the subtitler terminal 300, in operation S1300.Such an operation of receiving the subtitles may be performed by the input unit 320 of the subtitler terminal 300.Then, the subtitler terminal 300 may generate the subtitle signal and the subtitle delay signal, in operation S1400.The subtitler terminal 300 may generate the subtitle signal including information of the subtitles received from the user.", "Here, the subtitle signal may be a signal prepared in a programming language interpretable by the video providing apparatus 100 or the viewer terminal 400.Also, the subtitle signal may be an electronic signal generated such as to be transmitted through the communication unit 310 of the subtitler terminal 300 and received by the communication unit 110 of the video providing apparatus 100.As described above, the subtitle delay signal may be a signal including information for delaying the display of the subtitles.", "The subtitle signal and the subtitle delay signal may be generated by the controller 340 of the subtitler terminal 300.Then, the subtitler terminal 300 may transmit the subtitle signal and the subtitle delay signal to the video providing apparatus 100.The subtitle signal and the subtitle delay signal may be transmitted by the communication unit 310 of the subtitler terminal 300.Selectively, according to an embodiment of FIG.", "21, operation S1300 of the video providing method may include inputting a request to delay the display of the subtitles by the second time period (operation S1310), and operation S1400 may include generating the subtitle delay signal by including the information about the second time period.", "In detail, the user of the subtitler terminal 300 may estimate the time consumed while inputting the subtitles, i.e., the second time period.", "In this case, the subtitler terminal 300 may receive a request to display the subtitles by delaying the display by the second time period from the user.", "Then, the subtitler terminal 300 may generate the subtitle delay signal including the information about the second time period.", "According to a video providing method of the present disclosure, an original video is provided to a viewer terminal after being delayed by a certain time, and subtitles may be received from a subtitler terminal for the delayed time and then provided to the viewer terminal.", "Also, according to a video providing method of the present disclosure, information about a timing when subtitles are to be displayed may be provided to a viewer terminal together with the subtitles such that the subtitles are displayed at a right timing on a video provided to the viewer terminal.", "One or more of the above embodiments may be embodied in the form of a computer program that can be run in a computer through various elements.", "The computer program may be recorded on a computer-readable recording medium.", "Examples of the computer-readable recording medium include magnetic media (e.g., hard disks, floppy disks, and magnetic tapes), optical media (e.g., CD-ROMs and DVDs), magneto-optical media (e.g., floptical disks), and hardware devices specifically configured to store and execute program commands (e.g., ROMs, RAMs, and flash memories).", "Furthermore, the non-transitory computer-readable recording medium may be a formless medium that can be transmitted and distributed in a network, e.g., software or an application.", "The computer programs may be specially designed or well known to one of ordinary skill in the computer software field.", "Examples of the computer programs include code prepared by a compiler, and high-level languages executable by a computer by using an interpreter.", "The particular implementations shown and described herein are illustrative examples of the disclosure and are not intended to otherwise limit the scope of the disclosure in any way.", "For the sake of brevity, conventional electronics, control systems, software development and other functional aspects of the systems may not be described in detail.", "Furthermore, the connecting lines, or connectors shown in the various figures presented are intended to represent exemplary functional relationships and/or physical or logical couplings between the various elements.", "It should be noted that many alternative or additional functional relationships, physical connections or logical connections may be present in a practical device.", "Moreover, no item or component is essential to the practice of the disclosure unless the element is specifically described as “essential” or “critical”.", "It should be understood that embodiments described herein should be considered in a descriptive sense only and not for purposes of limitation.", "Descriptions of features or aspects within each embodiment should typically be considered as available for other similar features or aspects in other embodiments.", "Embodiments of the present disclosure are related to a video providing apparatus, a video providing method, and a computer program, and are usable in a video providing apparatus, a video providing method, and a computer program, which provide high convenience to a user watching a video by providing an original video to a viewer terminal by delaying the original video by a certain time, providing subtitles to the viewer terminal by receiving the subtitles from a subtitler terminal during the delayed time, and providing information about a timing of displaying the subtitles to the viewer terminal together with the subtitles such that the subtitles are displayed at a right timing on the video provided to the viewer terminal." ] ]
Patent_15872670
[ [ "SYSTEMS AND METHODS FOR NON-OBSTACLE AREA DETECTION", "A method performed by an electronic device is described.", "The method includes generating a depth map of a scene external to a vehicle.", "The method also includes performing first processing in a first direction of a depth map to determine a first non-obstacle estimation of the scene.", "The method also includes performing second processing in a second direction of the depth map to determine a second non-obstacle estimation of the scene.", "The method further includes combining the first non-obstacle estimation and the second non-obstacle estimation to determine a non-obstacle map of the scene.", "The combining includes combining comprises selectively using a first reliability map of the first processing and/or a second reliability map of the second processing The method additionally includes navigating the vehicle using the non-obstacle map." ], [ "1.A method performed by an electronic device, comprising: performing a first processing of a depth map in a first direction; generating a first reliability map based on the first processing; performing a second processing of at least a portion of the depth map in a second direction that is different from the first direction; generating a second reliability map based on the second processing; and identifying at least one non-obstacle area based on the depth map, the first reliability map, and the second reliability map.", "2.The method of claim 1, wherein performing the second processing of the at least a portion of the depth map comprises identifying unreliable regions of the depth map based on the first reliability map; and wherein the at least a portion of the depth map corresponds to the unreliable regions that were identified.", "3.The method of claim 1, wherein the first direction is horizontal and the second direction is vertical.", "4.The method of claim 1, wherein performing the first processing of the depth map comprises dividing the depth map into linear segments in the first direction.", "5.The method of claim 4, wherein the linear segments in the first direction are rows of pixels of the depth map.", "6.The method of claim 4, wherein the linear segments in the first direction are columns of pixels of the depth map.", "7.The method of claim 1, wherein the depth map comprises a depth map of a scene external to a vehicle.", "8.The method of claim 7, further comprising navigating the vehicle based on the at least one non-obstacle area.", "9.The method of claim 8, wherein navigating the vehicle comprises providing at least the non-obstacle area as input to an advanced driver assistance system (ADAS) to regulate at least one of speed or steering of the vehicle.", "10.The method of claim 8, wherein navigating the vehicle comprises using the non-obstacle area to identify a region of interest that is used by at least one of an object detection algorithm or a lane detection algorithm.", "11.An electronic device, comprising: at least one processor; a memory in communication with the at least one processor; and instructions stored in the memory, the instructions executable by the at least one processor to: perform a first processing of a depth map in a first direction; generate a first reliability map based on the first processing; perform a second processing of at least a portion of the depth map in a second direction that is different from the first direction; generate a second reliability map based on the second processing; and identify at least one non-obstacle area based on the depth map, the first reliability map, and the second reliability map.", "12.The electronic device of claim 11, wherein the instructions executable by the at least one processor to perform the second processing of the at least a portion of the depth map comprise instructions executable by the at least one processor to identify unreliable regions of the depth map based on the first reliability map; and wherein the at least a portion of the depth map corresponds to the unreliable regions that were identified.", "13.The electronic device of claim 11, wherein the first direction is horizontal and the second direction is vertical.", "14.The electronic device of claim 11, wherein the instructions executable by the at least one processor to perform the first processing of the depth map comprise instructions executable by the at least one processor to divide the depth map into linear segments in the first direction.", "15.The electronic device of claim 14, wherein the linear segments in the first direction are rows of pixels of the depth map.", "16.The electronic device of claim 14, wherein the linear segments in the first direction are columns of pixels of the depth map.", "17.The electronic device of claim 11, wherein the depth map comprises a depth map of a scene external to a vehicle.", "18.The electronic device of claim 17, wherein the instructions executable by the at least one processor are further executable to navigate the vehicle based on the at least one non-obstacle area.", "19.The electronic device of claim 18, wherein the instructions executable by the at least one processor to navigate the vehicle comprise instructions executable by the at least one processor to provide at least the non-obstacle area as input to an advanced driver assistance system (ADAS) to regulate at least one of speed or steering of the vehicle.", "20.The electronic device of claim 18, wherein the instructions executable by the at least one processor to navigate the vehicle comprise instructions executable by the at least one processor to use the non-obstacle area to identify a region of interest that is used by at least one of an object detection algorithm or a lane detection algorithm.", "21.A computer-program product, comprising a non-transitory tangible computer-readable medium having instructions thereon, the instructions comprising: code for causing an electronic device to perform a first processing of a depth map in a first direction; code for causing an electronic device to generate a first reliability map based on the first processing; code for causing an electronic device to perform a second processing of at least a portion of the depth map in a second direction that is different from the first direction; code for causing an electronic device to generate a second reliability map based on the second processing; and code for causing an electronic device to identify at least one non-obstacle area based on the depth map, the first reliability map, and the second reliability map.", "22.The computer-program product of claim 21, wherein the code for causing the electronic device to perform the second processing of the at least a portion of the depth map comprises code for causing the electronic device to identify unreliable regions of the depth map based on the first reliability map; and wherein the at least a portion of the depth map corresponds to the unreliable regions that were identified.", "23.The computer-program product of claim 21, wherein the first direction is horizontal and the second direction is vertical.", "24.The computer-program product of claim 21, wherein the code for causing the electronic device to perform the first processing of the depth map comprises code for causing the electronic device to divide the depth map into linear segments in the first direction.", "25.The computer-program product of claim 24, wherein the linear segments in the first direction are rows of pixels of the depth map.", "26.The computer-program product of claim 24, wherein the linear segments in the first direction are columns of pixels of the depth map.", "27.The computer-program product of claim 21, wherein the depth map comprises a depth map of a scene external to a vehicle.", "28.The computer-program product of claim 27, wherein the instructions further comprise further code for causing an electronic device to navigate the vehicle based on the at least one non-obstacle area.", "29.The computer-program product of claim 28, wherein the code for causing an electronic device to navigate the vehicle comprises code for causing an electronic device to provide at least the non-obstacle area as input to an advanced driver assistance system (ADAS) to regulate at least one of speed or steering of the vehicle.", "30.The computer-program product of claim 28, wherein the code for causing an electronic device to navigate the vehicle comprises code for causing an electronic device to use the non-obstacle area to identify a region of interest that is used by at least one of an object detection algorithm or a lane detection algorithm." ], [ "<SOH> BACKGROUND <EOH>In the last several decades, the use of electronic devices has become common.", "In particular, advances in electronic technology have reduced the cost of increasingly complex and useful electronic devices.", "Cost reduction and consumer demand have proliferated the use of electronic devices such that they are practically ubiquitous in modern society.", "As the use of electronic devices has expanded, so has the demand for new and improved features of electronic devices.", "More specifically, electronic devices that perform new functions and/or that perform functions faster, more efficiently or with higher quality are often sought after.", "Some electronic devices (e.g., cameras, video camcorders, digital cameras, cellular phones, smart phones, computers, televisions, etc.)", "capture and/or utilize images.", "For example, a smartphone may capture and/or process still and/or video images.", "In automotive and autonomous vehicle applications, obstacle detection may be performed by processing an image.", "Processing images may demand a relatively large amount of time, memory and energy resources.", "The resources demanded may vary in accordance with the complexity of the processing.", "It may be difficult to implement some complex processing tasks.", "For example, some platforms may have limited processing, memory and/or energy resources.", "Furthermore, some applications may be time sensitive.", "As can be observed from this discussion, systems and methods that improve image processing may be beneficial." ], [ "<SOH> SUMMARY <EOH>A method performed by an electronic device is described.", "The method includes performing vertical processing of a depth map to determine a vertical non-obstacle estimation.", "The method also includes performing horizontal processing of the depth map to determine a horizontal non-obstacle estimation.", "The method further includes combining the vertical non-obstacle estimation and the horizontal non-obstacle estimation.", "The method additionally includes generating a non-obstacle map based on the combination of the vertical and horizontal non-obstacle estimations.", "Performing vertical processing may include dividing the depth map into segments.", "At least one segment may include a number of pixels in a column.", "Linear model parameters may be estimated for at least one segment to determine the vertical non-obstacle estimation.", "A vertical reliability map that includes a reliability value for the vertical non-obstacle estimation may be generated.", "Determining the vertical reliability map may include determining a segment fitting error for a given segment based on a difference between the estimated linear model parameters and pre-determined linear model parameters.", "A reliability value for the given segment may be determined by comparing the segment fitting error to a vertical estimation threshold.", "The reliability value for the given segment may be applied to at least one pixel in the given segment.", "The pre-determined linear model parameters may be selected from among a plurality of road condition models.", "The plurality of road condition models may have a corresponding set of linear model parameters.", "Performing horizontal processing may include obtaining a depth histogram for at least one row of pixels of the depth map.", "A terrain line may be determined from the depth histogram.", "A horizontal non-obstacle estimation may be determined based on a distance of a depth value of at least one pixel from the terrain line.", "A horizontal reliability map may be generated that includes a reliability value for the horizontal non-obstacle estimation.", "Generating the horizontal reliability map may include determining whether the depth value of a given pixel is within a range of a mode of the depth histogram.", "The given pixel may have a high reliability value when the depth value of the given pixel is within the range of the mode of the depth histogram.", "Combining the vertical non-obstacle estimation and the horizontal non-obstacle estimation may include performing both the vertical processing and the horizontal processing in parallel.", "The vertical non-obstacle estimation and the horizontal non-obstacle estimation may be merged based on a vertical reliability map and a horizontal reliability map.", "A given pixel may be identified as a non-obstacle area in the non-obstacle map where both the vertical reliability map and the horizontal reliability map are characterized by a high reliability value for the given pixel.", "A given pixel may be identified as an obstacle area in the non-obstacle map where at least one of the vertical reliability map or the horizontal reliability map are characterized by a low reliability value for the given pixel.", "A given pixel may be identified as a non-obstacle area or obstacle area in the non-obstacle map based on a coordinate of the given pixel where the vertical reliability map and the horizontal reliability map are characterized by different reliability values for the given pixel.", "Combining the vertical non-obstacle estimation and the horizontal non-obstacle estimation may include performing vertical processing of the depth map.", "A vertical reliability map may be obtained based on a model fitting confidence.", "Reliable regions of the vertical reliability map may be identified as non-obstacle areas.", "Horizontal processing may be performed on unreliable regions of the vertical reliability map to determine whether the unreliable regions are non-obstacle areas.", "Combining the vertical non-obstacle estimation and the horizontal non-obstacle estimation may include performing horizontal processing of the depth map.", "A horizontal reliability map may be obtained based on a depth histogram distance.", "Reliable regions of the horizontal reliability map may be identified as non-obstacle areas.", "Vertical processing on unreliable regions of the horizontal reliability map may be performed to determine whether the unreliable regions are non-obstacle areas.", "The non-obstacle map may be used in identifying a region of interest used by at least one of an object detection algorithm or a lane detection algorithm.", "An electronic device is also described.", "The electronic device is configured to perform vertical processing of a depth map to determine a vertical non-obstacle estimation.", "The electronic device is also configured to perform horizontal processing of the depth map to determine a horizontal non-obstacle estimation.", "The electronic device is further configured to combine the vertical non-obstacle estimation and the horizontal non-obstacle estimation.", "The electronic device is additionally configured to generate a non-obstacle map based on the combination of the vertical and horizontal non-obstacle estimations.", "An apparatus is also described.", "The apparatus includes means for performing vertical processing of a depth map to determine a vertical non-obstacle estimation.", "The apparatus also includes means for performing horizontal processing of the depth map to determine a horizontal non-obstacle estimation.", "The apparatus further includes means for combining the vertical non-obstacle estimation and the horizontal non-obstacle estimation.", "The apparatus additionally includes means for generating a non-obstacle map based on the combination of the vertical and horizontal non-obstacle estimations.", "A computer-program product is also described.", "The computer-program product includes a non-transitory tangible computer-readable medium having instructions thereon.", "The instructions include code for causing an electronic device to perform vertical processing of a depth map to determine a vertical non-obstacle estimation.", "The instructions also include code for causing the electronic device to perform horizontal processing of the depth map to determine a horizontal non-obstacle estimation.", "The instructions further include code for causing the electronic device to combine the vertical non-obstacle estimation and the horizontal non-obstacle estimation.", "The instructions additionally include code for causing the electronic device to generate a non-obstacle map based on the combination of the vertical and horizontal non-obstacle estimations." ], [ "RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "15/685,390, filed Aug. 24, 2017, for “SYSTEMS AND METHODS FOR NON-OBSTACLE AREA DETECTION,” which is a continuation of U.S. patent application Ser.", "No.", "14/858,471, filed Sep. 18, 2015, for “SYSTEMS AND METHODS FOR NON-OBSTACLE AREA DETECTION,” now U.S. Pat.", "No.", "9,761,000, both of which are assigned to the assignee hereof and hereby expressly incorporated by reference herein.", "FIELD OF DISCLOSURE The present disclosure relates generally to electronic devices.", "More specifically, the present disclosure relates to systems and methods for non-obstacle area detection.", "BACKGROUND In the last several decades, the use of electronic devices has become common.", "In particular, advances in electronic technology have reduced the cost of increasingly complex and useful electronic devices.", "Cost reduction and consumer demand have proliferated the use of electronic devices such that they are practically ubiquitous in modern society.", "As the use of electronic devices has expanded, so has the demand for new and improved features of electronic devices.", "More specifically, electronic devices that perform new functions and/or that perform functions faster, more efficiently or with higher quality are often sought after.", "Some electronic devices (e.g., cameras, video camcorders, digital cameras, cellular phones, smart phones, computers, televisions, etc.)", "capture and/or utilize images.", "For example, a smartphone may capture and/or process still and/or video images.", "In automotive and autonomous vehicle applications, obstacle detection may be performed by processing an image.", "Processing images may demand a relatively large amount of time, memory and energy resources.", "The resources demanded may vary in accordance with the complexity of the processing.", "It may be difficult to implement some complex processing tasks.", "For example, some platforms may have limited processing, memory and/or energy resources.", "Furthermore, some applications may be time sensitive.", "As can be observed from this discussion, systems and methods that improve image processing may be beneficial.", "SUMMARY A method performed by an electronic device is described.", "The method includes performing vertical processing of a depth map to determine a vertical non-obstacle estimation.", "The method also includes performing horizontal processing of the depth map to determine a horizontal non-obstacle estimation.", "The method further includes combining the vertical non-obstacle estimation and the horizontal non-obstacle estimation.", "The method additionally includes generating a non-obstacle map based on the combination of the vertical and horizontal non-obstacle estimations.", "Performing vertical processing may include dividing the depth map into segments.", "At least one segment may include a number of pixels in a column.", "Linear model parameters may be estimated for at least one segment to determine the vertical non-obstacle estimation.", "A vertical reliability map that includes a reliability value for the vertical non-obstacle estimation may be generated.", "Determining the vertical reliability map may include determining a segment fitting error for a given segment based on a difference between the estimated linear model parameters and pre-determined linear model parameters.", "A reliability value for the given segment may be determined by comparing the segment fitting error to a vertical estimation threshold.", "The reliability value for the given segment may be applied to at least one pixel in the given segment.", "The pre-determined linear model parameters may be selected from among a plurality of road condition models.", "The plurality of road condition models may have a corresponding set of linear model parameters.", "Performing horizontal processing may include obtaining a depth histogram for at least one row of pixels of the depth map.", "A terrain line may be determined from the depth histogram.", "A horizontal non-obstacle estimation may be determined based on a distance of a depth value of at least one pixel from the terrain line.", "A horizontal reliability map may be generated that includes a reliability value for the horizontal non-obstacle estimation.", "Generating the horizontal reliability map may include determining whether the depth value of a given pixel is within a range of a mode of the depth histogram.", "The given pixel may have a high reliability value when the depth value of the given pixel is within the range of the mode of the depth histogram.", "Combining the vertical non-obstacle estimation and the horizontal non-obstacle estimation may include performing both the vertical processing and the horizontal processing in parallel.", "The vertical non-obstacle estimation and the horizontal non-obstacle estimation may be merged based on a vertical reliability map and a horizontal reliability map.", "A given pixel may be identified as a non-obstacle area in the non-obstacle map where both the vertical reliability map and the horizontal reliability map are characterized by a high reliability value for the given pixel.", "A given pixel may be identified as an obstacle area in the non-obstacle map where at least one of the vertical reliability map or the horizontal reliability map are characterized by a low reliability value for the given pixel.", "A given pixel may be identified as a non-obstacle area or obstacle area in the non-obstacle map based on a coordinate of the given pixel where the vertical reliability map and the horizontal reliability map are characterized by different reliability values for the given pixel.", "Combining the vertical non-obstacle estimation and the horizontal non-obstacle estimation may include performing vertical processing of the depth map.", "A vertical reliability map may be obtained based on a model fitting confidence.", "Reliable regions of the vertical reliability map may be identified as non-obstacle areas.", "Horizontal processing may be performed on unreliable regions of the vertical reliability map to determine whether the unreliable regions are non-obstacle areas.", "Combining the vertical non-obstacle estimation and the horizontal non-obstacle estimation may include performing horizontal processing of the depth map.", "A horizontal reliability map may be obtained based on a depth histogram distance.", "Reliable regions of the horizontal reliability map may be identified as non-obstacle areas.", "Vertical processing on unreliable regions of the horizontal reliability map may be performed to determine whether the unreliable regions are non-obstacle areas.", "The non-obstacle map may be used in identifying a region of interest used by at least one of an object detection algorithm or a lane detection algorithm.", "An electronic device is also described.", "The electronic device is configured to perform vertical processing of a depth map to determine a vertical non-obstacle estimation.", "The electronic device is also configured to perform horizontal processing of the depth map to determine a horizontal non-obstacle estimation.", "The electronic device is further configured to combine the vertical non-obstacle estimation and the horizontal non-obstacle estimation.", "The electronic device is additionally configured to generate a non-obstacle map based on the combination of the vertical and horizontal non-obstacle estimations.", "An apparatus is also described.", "The apparatus includes means for performing vertical processing of a depth map to determine a vertical non-obstacle estimation.", "The apparatus also includes means for performing horizontal processing of the depth map to determine a horizontal non-obstacle estimation.", "The apparatus further includes means for combining the vertical non-obstacle estimation and the horizontal non-obstacle estimation.", "The apparatus additionally includes means for generating a non-obstacle map based on the combination of the vertical and horizontal non-obstacle estimations.", "A computer-program product is also described.", "The computer-program product includes a non-transitory tangible computer-readable medium having instructions thereon.", "The instructions include code for causing an electronic device to perform vertical processing of a depth map to determine a vertical non-obstacle estimation.", "The instructions also include code for causing the electronic device to perform horizontal processing of the depth map to determine a horizontal non-obstacle estimation.", "The instructions further include code for causing the electronic device to combine the vertical non-obstacle estimation and the horizontal non-obstacle estimation.", "The instructions additionally include code for causing the electronic device to generate a non-obstacle map based on the combination of the vertical and horizontal non-obstacle estimations.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a block diagram illustrating an electronic device configured to perform non-obstacle area detection; FIG.", "2 is a block diagram illustrating a non-obstacle determination module; FIG.", "3 is a flow diagram illustrating a method for performing non-obstacle area detection; FIGS.", "4A-4D illustrate an example of a vertical processing of a depth map; FIG.", "5 is a flow diagram illustrating a method for performing non-obstacle area detection using vertical processing; FIGS.", "6A-6D illustrate an example of a horizontal processing of a depth map; FIG.", "7 is a flow diagram illustrating a method for performing non-obstacle area detection using horizontal processing; FIG.", "8 is a flow diagram illustrating a method for combining a vertical non-obstacle estimation and a horizontal non-obstacle estimation to determine a non-obstacle map; FIG.", "9 is a flow diagram illustrating another method for combining a vertical non-obstacle estimation and a horizontal non-obstacle estimation to determine a non-obstacle map; FIG.", "10 is a flow diagram illustrating yet another method for combining a vertical non-obstacle estimation and a horizontal non-obstacle estimation to determine a non-obstacle map; FIGS.", "11A-11B illustrate an example of determining non-obstacle areas in an image; FIGS.", "12A-12B illustrate another example of determining non-obstacle areas in an image; FIGS.", "13A-13B illustrate an example of determining distance from a non-obstacle area; FIG.", "14 illustrates an example of using the non-obstacle map to identify a region of interest (ROI) used by an object detection algorithm; FIG.", "15 illustrates an example of using the non-obstacle map to identify a ROI used by a lane detection algorithm; FIG.", "16 is a flow diagram illustrating a method for classifying a road based on estimated linear model parameters; and FIG.", "17 illustrates certain components that may be included within an electronic device.", "DETAILED DESCRIPTION In many applications, it is advantageous to identify non-object areas within a region or environment for obstacle avoidance.", "For example, with advanced driver assistance systems (ADAS), it is important to identify the drivable area in front of the car for obstacle avoidance.", "Another scenario in which obstacle avoidance is important is vehicular automation in which an autonomous vehicle (e.g., an unmanned aerial vehicle (UAV) or autonomous automobile) senses its environment and navigates without human input.", "Typically the problem of obstacle avoidance is looked at from the other direction, where objects of interest (e.g., pedestrians, cars, bicycles) are detected and may be identified via object detection/recognition algorithms and alerts are provided to the driver for taking precaution.", "For example, obstacle detection may be utilized to detect and identify traffic signs (e.g., speed limit signs, stop signs, street signs, etc.).", "However, this approach may be slow and inaccurate.", "Furthermore all the object classes have to be trained beforehand, which makes it difficult to ad din new object classes.", "In the systems and methods described herein, instead of identifying objects, regions are identified that are free of obstacles or objects.", "These regions may be referred to as moveable areas.", "In other words, these three dimensional regions are non-obstacle areas in which movement is possible.", "For example, a non-obstacle area may be identified on a road.", "Upon identifying non-obstacle areas, various other applications such as road profiling, speed control, faster and more reliable object, and lane detection may be performed using the non-obstacle area.", "The systems and methods described herein may be used to identify a non-obstacle area by analyzing a depth map.", "In an implementation, the depth map may be generated from a stereo image pair.", "In a road scenario, open space in the front may be mapped to a linear model that describes the road in the depth domain.", "By using the depth of road segments, linear model parameters may be estimated.", "The estimated linear model parameters may be compared with prior (e.g., pre-determined) model parameters.", "If fitting is achieved, then the segments are declared to be part of the open area.", "If a stereo image pair is not available, methods such as structure from motion can be used to obtain a depth map by using a mono camera input sequence.", "The systems and methods described herein provide for the determination of a non-obstacle map based on an intelligent combination of vertical processing and horizontal processing of one or more images.", "Systems and methods of performing identifying a non-obstacle area are explained in greater detail below.", "FIG.", "1 is a block diagram illustrating an electronic device 102 configured to perform non-obstacle area detection.", "The electronic device 102 may also be referred to as a wireless communication device, a mobile device, mobile station, subscriber station, client, client station, user equipment (UE), remote station, access terminal, mobile terminal, terminal, user terminal, subscriber unit, etc.", "Examples of electronic devices include laptop or desktop computers, cellular phones, smart phones, wireless modems, e-readers, tablet devices, gaming systems, robots, aircraft, unmanned aerial vehicles (UAVs), automobiles, etc.", "Some of these devices may operate in accordance with one or more industry standards.", "In many scenarios, the electronic device 102 may use a non-obstacle map 126 of a scene.", "In one example, a smartphone may generate a non-obstacle map 126 of a scene to identify unoccupied space.", "In another example, an automobile may include an advanced driver assistance system (ADAS) that may use a non-obstacle map 126 to regulate speed, steering, parking, etc., of the automobile based on detected traffic signs, signals and/or other objects.", "In another example, an unmanned aerial vehicle (UAV) may generate a non-obstacle map 126 from video recorded while in flight, may navigate based on detected objects (e.g., buildings, signs, people, packages, etc.", "), may pick up and/or deliver a detected package, etc.", "Many other examples may be implemented in accordance with the systems and methods disclosed herein.", "For instance, the systems and method disclosed herein could be implemented in a robot that performs one or more actions (e.g., fetching something, assembling something, searching for an item, etc.)", "based on one or more objects detected using the non-obstacle map 126.An electronic device 102 may include one or more cameras.", "A camera may include an image sensor 104 and an optical system 108 (e.g., lenses) that focuses images of objects that are located within the field of view of the optical system 108 onto the image sensor 104.An electronic device 102 may also include a camera software application and a display screen.", "When the camera application is running, images 114 of objects that are located within the field of view of the optical system 108 may be recorded by the image sensor 104.These images 114 may be stored in a memory buffer 112.In some implementations, the camera may be separate from the electronic device 102 and the electronic device 102 may receive image data from one or more cameras external to the electronic device 102.Although the present systems and methods are described in terms of captured images 114, the techniques discussed herein may be used on any digital image.", "Therefore, the terms video frame and digital image may be used interchangeably herein.", "In many applications, it is beneficial for an electronic device 102 to identify areas that are free of obstacles.", "For example, in the case of ADAS, it is important to identify the drivable area in front of the car for obstacle avoidance.", "In some approaches, this problem is looked at from the other direction.", "In these approaches, objects of interest (e.g., pedestrians, cars, bicycles) are identified via object detection and recognition algorithms and alerts are provided to the driver for taking precaution.", "Other approaches may determine non-obstacle areas by performing one of either vertical processing or horizontal processing of an image 114.Each of the vertical processing and horizontal processing may estimate non-obstacle areas in an image 114.However, each approach has limitations when performed independently.", "Horizontal processing may give an incorrect non-obstacle estimation when a road is slanted.", "Vertical processing may perform segmentation on the image 114.If the segments are large, then fitting is more reliable.", "However parts of objects could be included as non-obstacle (i.e., non-obstacle) areas as well.", "For example, using vertical processing, the bottom and top of cars or pedestrians may be incorrectly identified as a non-obstacle area.", "Also, sidewalks could be incorrectly identified as a non-obstacle area with the vertical processing approach.", "However, if segments are small, an inaccurate detection of non-obstacle area may occur.", "The systems and methods described herein provide for the determination of a non-obstacle map 126 based on an intelligent combination of vertical processing and horizontal processing of one or more images 114.In the described systems and methods, instead of identifying objects, a non-obstacle map 126 may be determined by combining vertical processing and horizontal processing of a depth map.", "In one implementation, the depth map may be obtained from one or more images.", "In another implementation, the depth map may be obtained from a depth data acquisition process (e.g., LIDAR).", "In an implementation, the electronic device 102 may include a non-obstacle determination module 116 for determining a non-obstacle map 126.The non-obstacle determination module 116 may include a depth map generator 118 for obtaining a depth map.", "The non-obstacle determination module 116 may also include a vertical estimation module 120 for performing vertical processing of the depth map to determine a vertical non-obstacle estimation.", "The non-obstacle determination module 116 may further include a horizontal estimation module 122 for performing horizontal processing of the depth map to determine a horizontal non-obstacle estimation.", "An estimation combiner 124 may combine the vertical non-obstacle estimation and the horizontal non-obstacle estimation to determine a non-obstacle map 126.In an implementation, the estimation combiner 124 may intelligently combine the vertical non-obstacle estimation and the horizontal non-obstacle estimation based on reliability values associated with the estimations.", "The non-obstacle map 126 may indicate which areas of the one or more images 114 are non-obstacle areas and which areas are obstacle areas.", "More detail on generating the non-obstacle map 126 is given in connection with FIG.", "2.In an example, the non-obstacle map 126 may include non-obstacle areas that are free of obstacles (e.g., objects) on the roads.", "By combining the vertical processing and horizontal processing of an image 114, false detections may be eliminated.", "Furthermore, a combined approach may provide a more reliable non-obstacle estimation.", "The described systems and methods may be used to speed up various other applications.", "For example, the electronic device 102 may use the non-obstacle map 126 for other applications such as object detection, scene understanding, road profiling, and lane detection.", "The described systems and methods may also solve the problem of road curb detection that current lane detection algorithms cannot handle.", "The described systems and methods may further help in autonomous driving, where the speed is adjusted based on the terrain of the road.", "FIG.", "2 is a block diagram illustrating a non-obstacle determination module 216.The non-obstacle determination module 216 may be implemented within an electronic or wireless device.", "The non-obstacle determination module 216 may include a depth map generator 218, a vertical estimation module 220, a horizontal estimation module 222 and an estimation combiner 224.The non-obstacle determination module 216, depth map generator 218, a vertical estimation module 220, a horizontal estimation module 222 and an estimation combiner 224 may be configurations of the non-obstacle determination module 116, depth map generator 118, a vertical estimation module 120, a horizontal estimation module 122 and an estimation combiner 124 described above in connection with FIG.", "1.The depth map generator 218 may receive one or more images 214.In a configuration, the one or more images 214 may be obtained via a camera (e.g., an image sensor 104 and optical system 108), as described in connection with FIG.", "1.In an implementation, the depth map generator 218 may receive a stereo image pair.", "In another implementation, the one or more images 214 may come from a video mono image.", "The image 214 may be a digital image made up of pixels.", "The depth map generator 218 may obtain a depth map 230 from the one or more images 214.The depth map 230 may include pixels 232 corresponding to the pixels of the one or more images 214.Each pixel 232 in the depth map 230 has a depth value 234.The depth value 234 indicates a distance of the pixel 232 relative to the camera.", "For example, a pixel 232 with a higher depth value 234 may indicate a closer proximity to the camera than a pixel 232 with a lower depth value 234.An example of a depth map 230 is discussed in connection with FIGS.", "4A-4D.", "It should be noted that the algorithm described herein does not require a depth value 234 for each pixel 232.For example, the depth map 230 may have holes.", "The depth value 234 of these holes may be filled in before starting processing.", "In the case of a stereo image pair, the depth map generator 218 may find the correspondence between pixels 232 to estimate a disparity.", "From the disparity, the depth map generator 218 may determine the depth value 234 for each pixel 232.Alternatively, with a video mono image, the depth map generator 218 may determine the depth value 234 for each pixel 232 based on the motion of the video.", "The depth map 230 may be provided to the vertical estimation module 220 and the horizontal estimation module 222.The vertical estimation module 220 may perform vertical processing of the depth map 230 to determine a vertical non-obstacle estimation 242.The horizontal estimation module 222 may perform horizontal processing of the depth map 230 to determine a horizontal non-obstacle estimation 258.The vertical estimation module 220 may divide the depth map 230 into segments 236.Each segment 236 may include a number of pixels 232 in a column of the depth map 230.In other words, the vertical estimation module 220 may process vertical segments 236 of the depth map 230.A segment 236 may be a portion of a column of pixels 232 in the depth map 230.For example, the segment 236 may be a vector of 10-15 pixels 232.The segments 236 may or may not overlap.", "The vertical estimation module 220 may estimate linear model parameters for each segment 236 to determine the vertical non-obstacle estimation 242.Each segment 236 in the vertical direction may be estimated via a linear model.", "The linear model may be expressed as y=p1x+p2, (1) where y is the depth value 234 of a pixel 232, x is the coordinate of the pixel 232, and p1 and p2 are the estimated linear model parameters 238.If the estimation error is less than a vertical estimation threshold 246 and the linear fit has certain slope, it may be labelled as valid free space (a non-obstacle area 266).", "In an implementation, a slope greater than 0 indicates non-obstacle, whereas a slope that is less than or equal to 0 indicates an object or obstacle.", "An example of this approach is discussed in connection with FIGS.", "4A-4D.", "In matrix form, the linear model of Equation (1) is given by Equation (2).", "[ y 1 y 2 y 3 ⋮ y n ] = [ x 1  1 x 2  1 x 3  1 ⋮ x n  1 ] × [ p 1 p 2 ] ( 2 ) In Equation (2), y is an n-by-1 vector of depth values 234, x is the n-by-2 design matrix (i.e., a matrix of n rows, 2 columns) for the model coordinates in the vertical dimension, and p1 and p2 are the estimated linear model parameters 238.The value of n corresponds to the number of pixels 232 in the depth map segment 236.In one approach, p1, and p2 may be solved using a least-squares solution.", "In this approach, p is a vector of the unknown coefficients p1, and p2.The normal equations are given by (XTX)p=XTy (3) where XT is the transpose of the design matrix X.", "Solving for p in Equation (4) results in the estimated linear model parameters 238 (i.e., p1 and p2).", "p=(XTX)−1XTy (4) It should be noted that in an optimized implementation, the matrix inversion term (XTX)−1XT is fixed based on the location (i.e., the y-coordinate) and could be pre-calculated based on location and stored.", "Also, a piecewise linear model could estimate dips and bumps in a surface, with variation in p1, p2 and segment length.", "Furthermore, the primary complexity of this approach is due to matrix multiplication of two vectors of size n in the above Equation (2).", "In an example, n may be 10 or the chosen piecewise length instead of 10.The vertical estimation module 220 may determine a vertical reliability map 248 a reliability value 250 for the vertical non-obstacle estimation 242.In an implementation, the vertical estimation module 220 may determine a segment fitting error 244 for each segment 236 based on the difference between the estimated linear model parameters 238 and pre-determined linear model parameters 240.The predetermined model parameters may be referred to as [pM1, pM2].", "The vertical estimation module 220 may check how close the predetermined model parameters are to the estimated parameters [p1, p2] by comparing to a threshold (TH1).", "For example, |p1−pM1|<TH1.The vertical estimation threshold 246 may determine if the estimated linear model parameters 238 fit into the trained model parameters.", "The pre-determined linear model parameters 240 may be selected from among a plurality of road condition models.", "Each of the plurality of road condition models may have a corresponding set of linear model parameters 240.Examples of the road condition models include a flat plane, hill, valley, etc.", "The pre-determined linear model parameters 240 may be determined by training.", "The vertical estimation module 220 may determine an estimated depth value (ŷi) using the estimated linear model parameters 238 according to Equation (5), where ŷi is the estimated depth value at the ith location.", "ŷi≡p1xi+p2 (5) A depth estimation error (ei) with the estimated linear model parameters 238 may be determined according to Equation (6), where yi is the depth value 234 at the ith location.", "ei≡yi−ŷi (6) The segment fitting error 244 (s2) may be determined according to Equation (7), where n is the length of the segment 236.s 2 = ∑ i = 1 n  e i 2 n - 2 ( 7 ) The segment fitting error 244 may be used as a reliability metric for vertical processing.", "The vertical estimation module 220 may determine the vertical reliability value 250 for each segment 236 by comparing the segment fitting error 244 of each segment 236 to a vertical estimation threshold 246.The vertical estimation threshold 246 may be based on the pre-determined linear model parameters 240.The vertical estimation threshold 246 may vary depending on which pre-determined linear model parameters 240 are used.", "For example, the vertical estimation threshold 246 may have one value if pre-determined linear model parameters 240 for a flat road are used.", "The vertical estimation threshold 246 may have a different value if pre-determined linear model parameters 240 for a hill are used.", "The vertical estimation module 220 may check the absolute value of the difference between the segment fitting error 244 and the vertical estimation threshold 246.A given segment 236 may have a high vertical reliability value 250 when the segment fitting error 244 for the given segment 236 is less than the vertical estimation threshold 246.Conversely, the given segment 236 may have a low vertical reliability value 250 when the segment fitting error 244 for the given segment 236 is greater than or equal to the vertical estimation threshold 246.Therefore, if the difference between the segment fitting error 244 and the vertical estimation threshold 246 is small, then the segment 236 is considered as part of a non-obstacle area 266.If the difference is large, then the segment 236 is not considered as part of a non-obstacle area 266.Upon determining the reliability value 250 for a given segment 236, the vertical estimation module 220 may threshold the vertical reliability map 248 to get a binary map.", "The reliability value 250 for a given segment 236 may be compared with a threshold to determine whether the segment 236 is a non-object area (e.g., movable) or an object area (e.g., non-moveable area).", "The vertical reliability map 248 may include the reliability values 250 of the pixels 232 in the depth map 230.Therefore, the vertical reliability map 248 is a map that has a fitting confidence per depth pixel 232 as well as per segment 236.The horizontal estimation module 222 may perform horizontal processing of the depth map 230 to determine a horizontal non-obstacle estimation 258.The horizontal processing may include obtaining a depth histogram 252 for each row of pixels 232 of the depth map 230.An example of the depth histogram 252 is described in connection with FIGS.", "6A-6D.", "The depth histogram 252 may also be referred to as a disparity histogram.", "In an implementation, the depth histogram 252 may be obtained by obtaining a histogram for each row in the depth map 230.For example, for a row of pixels 232 from the depth map 230, a histogram may be generated for the depth values 234 corresponding to the pixels 232 in the row.", "The horizontal estimation module 222 may determine a terrain line 254 from the depth histogram 252.The y-coordinate of the end points of the terrain line 254 determine the closest and farthest free space distance.", "The terrain line 254 may be determined using a line extraction approach.", "A Hough transform may be applied on the depth histogram 252.The Hough transform may extract multiple line segments from the depth histogram 252.For example, the Hough transform may generate 10-20 small lines.", "The line segments may be merged to form the terrain line 254.In an implementation, the angle of the terrain line 254 may be limited (e.g., between −20 degrees and −40 degrees) based on slope characteristics of non-obstacle space.", "The horizontal estimation module 222 may determine the horizontal non-obstacle estimation 258 for each pixel 232 based on the distance of the depth value 234 of each pixel 232 from the terrain line 254.A pixel 232 that has a depth value 234 that lies within a horizontal estimation threshold 260 of the terrain line 254 may be identified as a non-obstacle area 266.For example, if the depth value 234 of a pixel 232 lies within a certain disparity range of the terrain line 254, then that pixel 232 may be labeled as a non-obstacle area 266.If the depth value 234 of a pixel 232 lies outside the certain disparity range of the terrain line 254, then that pixel 232 may be labeled as an obstacle area 268.The horizontal estimation module 222 may also determine a horizontal reliability map 262 based on a depth histogram 252 distance.", "The horizontal reliability map 262 may include a reliability value 264 for the horizontal non-obstacle estimation 258 of each pixel 232.The distance to the mode 256 of the depth histogram 252 may be used as a reliability metric for the horizontal processing.", "The horizontal estimation module 222 may determine whether the depth value 234 of each pixel 232 is within a reliability threshold 261 of the mode 256 of the depth histogram 252.A given pixel 232 may have a high reliability value 264 when the depth value 234 of the given pixel 232 is within the reliability threshold 261 of the mode 256 of the depth histogram 252.The estimation combiner 224 may combine the vertical non-obstacle estimation 242 and the horizontal non-obstacle estimation 258 to determine the non-obstacle map 226.This combination may be based on the vertical reliability values 250 and the horizontal reliability values 264.In one approach, the vertical processing and horizontal processing may be performed in parallel and the resulting non-obstacle estimations 242, 258 merged.", "In another approach, the vertical processing and horizontal processing may be performed sequentially and the resulting non-obstacle estimations merged.", "For the parallel processing approach, both the vertical processing and the horizontal processing may be performed in parallel.", "For example, the vertical estimation module 220 may perform vertical processing and the horizontal estimation module 222 may simultaneously perform horizontal processing as described above.", "The estimation combiner 224 may generate the non-obstacle map 226 by identifying each pixel 232 as a non-obstacle area 266 or obstacle area 268.This identification may be based on the vertical reliability values 250 of the vertical reliability map 248 and the horizontal reliability values 264 of the horizontal reliability map 262.If both the vertical reliability map 248 and the horizontal reliability map 262 indicate that a pixel 232 has a high reliability, then the pixel 232 may be identified as a non-obstacle area 266 in the non-obstacle map 226.In other words, a given pixel 232 may be identified as a non-obstacle area 266 in the non-obstacle map 226 where both the vertical reliability map 248 and the horizontal reliability map 262 are characterized by a high reliability value for the given pixel 232.In an implementation, this may be achieved by thresholding the vertical reliability map 248 and the horizontal reliability map 262 with a respective threshold.", "For example, if a vertical reliability value 250 and a horizontal reliability value 264 of a given pixel 232 are greater than a threshold, then the pixel 232 may be identified as a non-obstacle area 266.In the case of both the vertical reliability map 248 and the horizontal reliability map 262 indicating low reliability, the pixel 232 may be labeled as an obstacle area 268.For the case where either of the vertical reliability map 248 or the horizontal reliability map 262 indicates a high reliability and the other indicates a low reliability, one or more different merging approaches may be performed.", "In one approach, if at least one of the vertical reliability map 248 or the horizontal reliability map 262 indicates that the given pixel 232 has a low reliability, then the given pixel 232 is identified as an obstacle area 268 in the non-obstacle map 226.In other words, a given pixel 232 may be identified as an obstacle area 268 in the non-obstacle map 226 where at least one of the vertical reliability map 248 or the horizontal reliability map 262 are characterized by a low reliability value for the given pixel 232.In this approach, if one of the reliability maps 248, 262 is indicating low reliability, the pixel 232 may be labeled based only on that reliability map 248, 262.In another approach, the vertical reliability map 248 and the horizontal reliability map 262 are characterized by different reliability values 250, 264 for a given pixel 232.In this case, the given pixel 232 may be identified as a non-obstacle area 266 or obstacle area 268 based on the coordinate of the given pixel 232.In this approach, if both reliability maps 248, 262 are close to each other in terms of reliability (e.g., one being higher than other), the decision can be further enhanced by considering the pixel 232 coordinates.", "In an example, RHij is the horizontal reliability value 264 for ith and jth pixel 232 from horizontal processing, and RVij is the vertical reliability value 250 from vertical processing (where both reliability values 250, 264 are normalized if obtained by different methods).", "If |RHij−RVij|<TH, then this will indicate closeness of reliability maps 248, 262.Furthermore, RHij could be compared to RVi+n,j+n, where n is <N (for e.g.", "N=5 for 720p resolution).", "For the sequential processing approach, either vertical processing or horizontal processing may be performed first.", "After the first processing is performed, the reliability map (e.g., either the vertical reliability map 248 or the horizontal reliability map 262) may be calculated for whole depth map 230.For pixels 232 where reliability is not met, a second processing is called.", "The results of the first and second processing may be merged to obtain the non-obstacle map 226.An example of sequential processing starting with vertical processing is described in connection with FIG.", "9.An example of sequential processing starting with horizontal processing is described in connection with FIG.", "10.The non-obstacle determination module 216 may perform additional processing of the non-obstacle map 226.In an implementation, the non-obstacle determination module 216 may perform outlier removal.", "For example, a small number of pixels 232 may be incorrectly labeled obstacle area 268 within a non-obstacle area 266.The non-obstacle determination module 216 may identify these outliers and change their status to either non-obstacle of obstacle.", "The non-obstacle determination module 216 may perform additional filtering of the non-obstacle map 226 to prepare it for subsequent operations.", "The non-obstacle map 226 may be used for different operations.", "In one implementation, the non-obstacle map 226 may be used to identify a region of interest used by an object detection algorithm.", "This may be accomplished as described in connection with FIG.", "14.In another implementation, the non-obstacle map 226 may be used to identify a region of interest used by a lane detection algorithm.", "This may be accomplished as described in connection with FIG.", "15.As illustrated in FIG.", "2, one or more of the illustrated components may be optionally implemented by a processor 228.For example, the non-obstacle determination module 216 may be implemented by a processor 228.In some configurations, different processors may be used to implement different components (e.g., one processor may implement the depth map generator 218, another processor may be used to implement the vertical estimation module 220, another processor may be used to implement the horizontal estimation module 222 and yet another processor may be used to implement the estimation combiner 224).", "It should be noted that it is possible that to rotate the image 214 and perform diagonal processing.", "If an image 214 is rotated, the vertical and horizontal processing may become diagonal processing.", "Therefore, while the terms vertical and horizontal processing are used herein, it may be recognized that processing could be applied across a different section through the rotated image with corresponding coordinate mapping.", "FIG.", "3 is a flow diagram illustrating a method 300 for performing non-obstacle area detection.", "The method 300 may be implemented by, with reference to FIG.", "1, an electronic device 102, e.g., a non-obstacle determination module 116.The electronic device 102 may obtain 302 a depth map 230 from one or more images 214.In one implementation, the electronic device 102 may generate the depth map 230 from a stereo image pair.", "In another implementation, the electronic device 102 may generate the depth map 230 from a video mono image.", "Each pixel 232 in the depth map 230 may have a depth value 234.The electronic device 102 may perform 304 vertical processing of the depth map 230 to determine a vertical non-obstacle estimation 242.The vertical processing may include dividing the depth map 230 into segments 236.Each segment 236 may include a number of pixels 232 in a column.", "The electronic device 102 may estimate linear model parameters 238 for each segment 236 to determine the vertical non-obstacle estimation 242.The electronic device 102 may determine a vertical reliability map 248 that includes a reliability value 250 for the vertical non-obstacle estimation 242.The electronic device 102 may perform 306 horizontal processing of the depth map 230 to determine a horizontal non-obstacle estimation 258.The horizontal processing may include obtaining a depth histogram 252 for each row of pixels 232 of the depth map 230.The electronic device 102 may determine a terrain line 254 from the depth histogram 252.The electronic device 102 may determine the horizontal non-obstacle estimation 258 for each pixel 232 based on the distance of the depth value 234 of each pixel 232 from the terrain line 254.The electronic device 102 may also determine a horizontal reliability map 262 that includes a reliability value 264 for the horizontal non-obstacle estimation 258 of each pixel 232.The electronic device 102 may combine 308 the vertical non-obstacle estimation 242 and the horizontal non-obstacle estimation 258 to determine a non-obstacle map 226.In one implementation, the electronic device 102 may perform parallel vertical processing and horizontal processing.", "In this implementation, the electronic device 102 may combine the vertical non-obstacle estimation 242 and the horizontal non-obstacle estimation 258, as described in connection with FIG.", "10.In another implementation, the electronic device 102 may perform sequential processing starting with vertical processing, as described in connection with FIGS.", "11A-11B.", "In yet another implementation, the electronic device 102 may perform sequential processing starting with horizontal processing, as described in connection with FIGS.", "12A-12B.", "FIGS.", "4A-4D illustrate an example of a vertical processing of a depth map 430.The depth map 430 may be generated from one or more images 404.The depth map 430 may include locations corresponding to the pixels of the original image(s) 404.Each location (e.g., coordinate) in the depth map 430 may have a horizontal coordinate 472 and a vertical coordinate 474a corresponding to the pixels of the original image(s) 404.The depth map 430 may match the size of the original image 404 if the depth is calculated from the original resolution.", "In the visualization of a depth map 430, the depth value 434 may be obtained from the corresponding coordinates of the original image 404.It should be noted that a visualization of the depth map 430 may or may not be generated when generating a non-obstacle map 226.Each pixel 232 of the depth map 430 may have a depth value 434.In this example, the depth values 434a may range from 0 to 120, where 0 indicates the farthest distance and 120 indicates the nearest distance.", "It should be noted that different values may be used for the depth values 434.In an implementation, the disparity to depth mapping can be explained by the following equations.", "Z=fB/d, where Z is the distance along the camera Z axis, f is the focal length (in pixels), B is the baseline (in meters), d is the disparity (in pixels).", "When the disparity is small, the depth is large.", "The depth can be found in terms of meters.", "It should be noted that depth estimation algorithms from stereo images 404 may not be completely reliable.", "For example, a depth estimation algorithm might not be able to assign depth values 434 in certain regions.", "A depth filling algorithm may be used to fill in the missing depth values 434.For example the neighboring depth value 434 may be propagated to an adjoining area.", "The propagation may be from left or from right.", "Alternatively, missing depth values 434 may be filled by interpolating between left and right, as well as top and bottom.", "This example shows a first column 470a and a second column 470b.", "In a first column graph 475a, the depth values 434b are shown for the pixels 232 in the first column 470a.", "In this first column graph 475a, the depth values 434b are plotted verses the vertical coordinates 474b of the pixels 232 from the first column 470a.", "It should be noted that in this example, the zero values from 0 to 40 and after 400 pixels is because there is no depth assigned there.", "Because stereo images may be calibrated, they may not have the matching field of view (FOV) after calibration.", "Depth estimation may only be performed only within same FOV.", "In a second column graph 475b, the depth values 434c are shown for the pixels 232 in the second column 470b.", "In this second column graph 475b, the depth values 434c are plotted verses the vertical coordinates 474c of the pixels 232 from the second column 470b.", "The dashed line from 0 to 150 is the mapping showing the algorithm result.", "The mapping may only be to sloped (i.e., slanted) lines (which specify a non-object road area).", "To map to objects (which are flat lines), then the same algorithm may be used, but the mapping parameters may be changed.", "The solid line in the graphs 475a,b comes from original depth values.", "The dashed line is generated according to the described systems and methods.", "It should be noted that the mapping may be based on the slope of the dashed line.", "In these graphs 475a,b, a slope greater than 0 indicates a non-obstacle area 266.A slope less than or equal to 0 indicates an obstacle area 268.During vertical processing, the electronic device 102 may divide the depth map 430 into segments 236.Each segment 236 may include a number of pixels 232 in a column 470.For example, the segment 236 may be a vector of 10-15 pixels 232.The electronic device 102 may determine a vertical non-obstacle estimation 242 and may estimate linear model parameters 238 as described in connection with FIG.", "2.If the estimation error is less than a threshold 246 and the linear fit has a certain slope, then the segment 236 may be labelled as a valid non-obstacle area 266.FIG.", "5 is a flow diagram illustrating a method 500 for performing non-obstacle area detection using vertical processing.", "The method 500 may be implemented by an electronic device 102, e.g., a non-obstacle determination module 116.The electronic device 102 may divide 502 a depth map 430 into segments 236.Each segment 236 may include a number n of pixels 232 in a column 470.In an implementation, n may equal 10 pixels 232.The electronic device 102 may estimate 504 linear model parameters 238 for each segment 236 to determine the vertical non-obstacle estimation 242.This may be accomplished according to Equations 1-4 described above.", "The electronic device 102 may determine 506 a vertical reliability map 248 that includes a reliability value 250 for the vertical non-obstacle estimation 242.For example, the electronic device 102 may determine a segment fitting error 244 for each segment 236 based on the difference between the estimated linear model parameters 238 and pre-determined linear model parameters 240.The segment fitting error 244 may be determined according to Equations 5-7 above.", "The pre-determined linear model parameters 240 may be selected from among a plurality of road condition models (e.g., flat, hill, valley).", "Each of the plurality of road condition models may have a corresponding set of linear model parameters 240.The electronic device 102 may determine the reliability value 250 for each segment 236 by comparing the segment fitting error 244 of each segment 236 to a vertical estimation threshold 246.A given segment 236 may have a high reliability value 250 when the segment fitting error 244 for the given segment 236 is less than the vertical estimation threshold 246.The electronic device 102 may apply the reliability value 250 for a given segment 236 to each pixel 232 in the given segment 236.Therefore, each pixel 232 in the vertical reliability map 248 may have a reliability value 250 indicating confidence in the vertical non-obstacle estimation 242.FIGS.", "6A-6D illustrate an example of a horizontal processing of a depth map 630.The depth map 630 may be generated from one or more images 114.The depth map 630 illustrated in FIG.", "6A is the same depth map 430 described in connection with FIG.", "4B (compressed to fit the page).", "The depth map 630 may include locations corresponding to the pixels of the original image(s) 114.Each location in the depth map 630 may have a horizontal coordinate 672 and a vertical coordinate 674 corresponding to the pixels 232 of the original image(s) 114.The electronic device 102 may generate a depth histogram 652.The depth histogram 652 may be generated by obtaining a histogram of depths for each row in the depth map 630.For example, the depth histogram 652 may be generated by projecting the depth map 630 in the vertical axis.", "A depth histogram 652 may be calculated for each row in an image 114.The number of bins in the depth histogram 652 corresponds to the number of maximum disparity values in the image 114.For example, it could be 150 for a 720p image, or it could be larger for a larger resolution image and smaller for a smaller resolution image.", "The x axis in the right side of FIG.", "6B corresponds to disparity values, and the intensity value in the image 114 corresponds to the histogram count for that disparity value.", "The darker the shade it is, the higher the disparity value, the lighter the shade it is, the lower the disparity value of histogram.", "In this example, a maximum number of disparity bins is 150.In the depth histogram 652, disparity values are plotted versus the vertical coordinates 674.The electronic device 102 may apply a Hough transform on the depth histogram 652 to extract line segments 676.The Hough transform may extract multiple line segments 676 from the depth histogram 252.For example, the Hough transform may generate 10-20 small line segments 676.The line segments 676 may be merged to form the terrain line 654.The x-coordinate of the end points of the terrain line 254 determine the closest and farthest free space distance.", "In an implementation, the angle of the terrain line 254 may be limited (e.g., between −20 degrees and −40 degrees) as non-obstacle space has certain slope characteristics.", "If the depth histogram 652 gives a line with a negative slope, it corresponds to a road segment in front of the car without any obstacles.", "An obstacle will be represented by a straight vertical line at 90 degrees.", "The terrain line 254 indicates that the depth values in front of the camera are slowly decreasing as the depth values are analyzed in rows of an image 114.If there is an object, then the object will have same depth value for a certain number of rows.", "In this case, depth values will not be decreasing.", "The slope (i.e., angle of the terrain line 254) may be chosen according to the maximum slope a road can have.", "The electronic device 102 may label the pixels 232 with depth values 634 that lie within a horizontal estimation threshold 260 of the terrain line 654 as non-obstacle areas 266.Those pixels 232 with depth values 634 that lie outside the horizontal estimation threshold 260 of the terrain line 654 may be labeled as obstacle areas 268.FIG.", "7 is a flow diagram illustrating a method 700 for performing non-obstacle area detection using horizontal processing.", "The method 700 may be implemented by an electronic device 102, e.g., a non-obstacle determination module 116.The electronic device 102 may obtain 702 a depth histogram 252 for each row of pixels 232 of the depth map 230.This may be accomplished as described in connection with FIGS.", "6A-6D.", "The electronic device 102 may determine 704 a terrain line 254 from the depth histogram 252.This may be accomplished as described in connection with FIGS.", "6A-6D.", "The electronic device 102 may determine 706 a horizontal non-obstacle estimation 258 for each pixel 232 based on the distance of the depth value 234 of each pixel 232 from the terrain line 254.Those pixels 232 with depth values 634 that lie within a horizontal estimation threshold 260 of the terrain line 654 may be labeled as non-obstacle areas 266.Those pixels 232 with depth values 634 that lie outside the horizontal estimation threshold 260 of the terrain line 654 may be labeled as obstacle areas 268.The electronic device 102 may determine 708 a horizontal reliability map 262 that includes a reliability value 264 for the horizontal non-obstacle estimation 258 of each pixel 232.For example, the distance to the mode 256 of the depth histogram 252 may be used as a reliability metric for the horizontal processing.", "The electronic device 102 may determine whether the depth value 234 of each pixel 232 is within a reliability threshold 261 of the mode 256 of the depth histogram 252.A given pixel 232 may have a high reliability value 264 when the depth value 234 of the given pixel 232 is within the reliability threshold 261 of the mode 256 of the depth histogram 252.FIG.", "8 is a flow diagram illustrating a method 800 for combining a vertical non-obstacle estimation 242 and a horizontal non-obstacle estimation 258 to determine a non-obstacle map 226.The method 800 may be implemented by an electronic device 102, e.g., a non-obstacle determination module 116.In this method 800, the electronic device 102 may perform vertical processing and horizontal processing in parallel.", "The electronic device 102 may perform 802 vertical processing of a depth map 230 to determine a vertical non-obstacle estimation 242.This may be accomplished as described in connection with FIG.", "5.The electronic device 102 may obtain 804 a vertical reliability map 248 based on a model fitting confidence.", "This may be accomplished as described in connection with FIG.", "5.The electronic device 102 may perform 806 horizontal processing of the depth map 230 to determine a horizontal non-obstacle estimation 258.This may be accomplished as described in connection with FIG.", "7.The electronic device 102 may obtain 808 a horizontal reliability map 262 based on a depth histogram 252 distance.", "This may be accomplished as described in connection with FIG.", "7.It should be noted that steps 802, 804, 806, 808 may be performed in parallel.", "For example, while the electronic device 102 performs the vertical processing steps 802 and 804, the electronic device 102 may simultaneously perform the horizontal processing steps 806 and 808.The electronic device 102 may merge 810 the vertical non-obstacle estimation 242 and the horizontal non-obstacle estimation 258 to obtain the non-obstacle map 226.This merge may be based on the vertical reliability map 248 and the horizontal reliability map 262.If both the vertical reliability map 248 and the horizontal reliability map 262 indicate that a pixel 232 has a high reliability, then the pixel 232 may be identified as a non-obstacle area 266 in the non-obstacle map 226.For example, if the vertical reliability map 248 indicates a high vertical reliability value 250 and the horizontal reliability map 262 indicates a high horizontal reliability value 264, then the pixel 232 may be labeled as a non-obstacle area 266 in the non-obstacle map 226.For the case where either of the vertical reliability map 248 or the horizontal reliability map 262 indicates a high reliability and the other indicates a low reliability, one or more different merging approaches may be performed.", "In one approach, if at least one of the vertical reliability map 248 or the horizontal reliability map 262 indicates that the given pixel 232 has a low reliability value 250, 264, then the given pixel 232 is identified as an obstacle area 268 in the non-obstacle map 226.In another approach, the vertical reliability map 248 and the horizontal reliability map 262 may indicate different reliability values 250, 264.In this case, the given pixel 2332 may be identified as a non-obstacle area 266 or obstacle area 268 based on the coordinate of the given pixel 232.FIG.", "9 is a flow diagram illustrating another method 900 for combining a vertical non-obstacle estimation 242 and a horizontal non-obstacle estimation 258 to determine a non-obstacle map 226.The method 900 may be implemented by an electronic device 102, e.g., a non-obstacle determination module 116.In this method 900, the electronic device 102 may perform a sequential application of vertical processing followed by horizontal processing.", "The electronic device 102 may perform 902 vertical processing of a depth map 230 to determine a vertical non-obstacle estimation 242.This may be accomplished as described in connection with FIG.", "5.The electronic device 102 may obtain 904 a vertical reliability map 248 based on a model fitting confidence.", "This may be accomplished as described in connection with FIG.", "5.The electronic device 102 may identify 906 reliable regions as non-obstacle areas 266 based on the vertical reliability map 248.For example, each pixel 232 that has a high vertical reliability value 250 in the vertical reliability map 248 may be labeled as a non-obstacle area 266 in the non-obstacle map 226.The electronic device 102 may perform 908 horizontal processing on unreliable regions of the vertical reliability map 248 to determine whether the unreliable regions are non-obstacle areas 266.For example, the electronic device 102 may perform horizontal processing on at least one row of pixels 232 that have a low reliability value 250.It should be noted that the length of a row could be as wide as the image 114 or could be shorter than the image width.", "The horizontal processing may be accomplished as described in connection with FIG.", "7 to determine a horizontal non-obstacle estimation 258.The non-obstacle map 226 may be updated based on the results of the horizontal reliability map 262 of the unreliable regions.", "FIG.", "10 is a flow diagram illustrating yet another method 1000 for combining a vertical non-obstacle estimation 242 and a horizontal non-obstacle estimation 258 to determine a non-obstacle map 226.The method 1000 may be implemented by an electronic device 102, e.g., a non-obstacle determination module 116.In this method 1000, the electronic device 102 may perform a sequential application of horizontal processing followed by vertical processing.", "The electronic device 102 may perform 1002 horizontal processing of a depth map 230 to determine a horizontal non-obstacle estimation 258.This may be accomplished as described in connection with FIG.", "7.The electronic device 102 may obtain 1004 a horizontal reliability map 262 based on a depth histogram 252 distance.", "This may be accomplished as described in connection with FIG.", "7.The electronic device 102 may identify 1006 reliable regions as non-obstacle areas 266 based on the horizontal reliability map 262.For example, each pixel 232 that has a high horizontal reliability value 264 in the horizontal reliability map 262 may be labeled as a non-obstacle area 266 in the non-obstacle map 226.The electronic device 102 may perform 1008 vertical processing on unreliable regions of the horizontal reliability map 262 to determine whether the unreliable regions are non-obstacle areas 266.For example, the electronic device 102 may perform vertical processing on one or more column(s) of pixels 232 that have a low horizontal reliability value 264.The one or more column(s) of pixels 232 may be as tall as the image 114 or could be less than the image height.", "The vertical processing may be accomplished as described in connection with FIG.", "5 to determine a vertical non-obstacle estimation 242.The non-obstacle map 226 may be updated based on the results of the vertical reliability map 248 of the unreliable regions.", "FIGS.", "11A-11B illustrate an example of determining non-obstacle areas 1166 in an image 1114.In this example, the original image 1114a is an image of a one-way road.", "The processed image 1114b shows the non-obstacle area 1166 that is determined according to the systems and methods described herein.", "The processed image 1114b shows an example from an intermediate step of the algorithm, not the final result.", "This is to show there could be holes in the non-obstacle map 126 that should be further processed.", "Also this illustrates the result from vertical processing alone.", "The non-obstacle area 1166 includes the open area corresponding to the road.", "Certain outlier areas 1178 in non-obstacle area 1166 were not identified as part of the non-obstacle area 1166.As used herein, outlier means that the depth values in the image 1114b did not fit in the predetermined model.", "This may be due to a possible wrong estimation of depth values (e.g., input depth values may not be perfect), so some areas appear as holes (or outliers).", "These outlier areas 1178 may be removed by performing additional processing of the image 1114.FIGS.", "12A-12B illustrate another example of determining non-obstacle areas 1266 in an image 1214.In this example, the original image 1214a is an image of an intersection.", "The processed image 1214b shows the non-obstacle area 1266 that is determined according to the systems and methods described herein.", "FIGS.", "13A-13B illustrate an example of determining distance 1380 from a non-obstacle area 1366.This example shows the processed image 1314 of the road described in connection with FIGS.", "11A-11B.", "The non-obstacle area 1366 is determined according to the systems and methods described herein.", "In the depth map 1330 of FIG.", "13B, the x and y coordinates are the coordinate positions and the shading is indicative of depth.", "In this example, the depth map 1330 includes the depth information for the non-obstacle area 1366.The depth map 1330 indicates how far there will be free space in front of the camera.", "Using the depth values 234 from the depth map 1330, the electronic device 102 may determine various distances associated with the non-obstacle area 1366b.", "For example, the electronic device 102 may determine that the farthest distance in the non-obstacle area 1366b is between 45-50 meters away from the image sensor 104.Similarly, the electronic device 102 may determine that the nearest cars are approximately 11 meters from the image sensor 104.FIG.", "14 illustrates an example of using the non-obstacle map 226 to identify a region of interest (ROI) 1482 used by an object detection algorithm.", "This example shows the processed image 1414 of the road described in connection with FIGS.", "11A-11B.", "The non-obstacle area 1466 is determined according to the systems and methods described herein.", "The electronic device 102 may then identify one or more ROI 1482 for a potential obstacle area 268.For example, the electronic device 102 may identify obstacle areas 268 from the non-obstacle map 226.In an implementation, pixels 232 that are not labeled as non-obstacle area 1466 may be identified as an obstacle area 268.These obstacle areas 268 may be included in one or more ROIs 1482.In this example, the electronic device 102 identifies four ROIs 1482a-d as potential object areas.", "The electronic device 102 may run an object detector in the identified ROIs 1482.For example, the electronic device 102 may detect whether an ROI 1482 includes a car, traffic signal, a pedestrian, lanes, curbs, etc.", "Identifying the non-obstacle area 1466 first results in a reduced search area for the object detection.", "This may reduce the amount of processing that is performed for object detection.", "FIG.", "15 illustrates an example of using the non-obstacle map 226 to identify a region of interest (ROI) 1582 used by a lane detection algorithm.", "This example shows the processed image 1514 of a road.", "The non-obstacle area 1566 is determined according to the systems and methods described herein.", "The electronic device 102 may then identify one or more ROI 1582 for road sides and/or curbs.", "For example, the electronic device 102 may identify obstacle areas 268 from the non-obstacle map 226.In this example, the electronic device 102 identifies two ROIs 1582a-b on the sides of the non-obstacle area 1566 as potential road sides and/or curbs.", "The electronic device 102 may run a lane detector in the identified ROIs 1582a-b.", "Identifying the non-obstacle area 1566 first results in a reduced search area for the lane detection.", "This may reduce the amount of processing that is performed for lane detection.", "FIG.", "16 is a flow diagram illustrating a method 1600 for classifying a road based on estimated linear model parameters 238.The method 1600 may be implemented by an electronic device 102, e.g., a non-obstacle determination module 116.The electronic device 102 may obtain 1602 a depth map 230 of a road image 114.The depth map 230 may be generated as described in connection with FIG.", "2.The electronic device 102 may perform 1604 segment fitting to estimate linear model parameters 238.The estimated linear model parameters 238 may be determined as described in connection with FIG.", "2.The electronic device 102 may classify 1606 the road based on the estimated linear model parameters 238.For example, the electronic device 102 may compare the estimated linear model parameters 238 with a plurality of pre-determined linear model parameters 240.As described above, the pre-determined linear model parameters 240 may be associated with a plurality of road condition models.", "Each of the plurality of road condition models may have a corresponding set of linear model parameters 240.Examples of the road condition models include a flat plane, slope (e.g., hill), valley, irregular road, etc.", "In an implementation, the pre-determined linear model parameters 240 can be obtained via training.", "Pre-labeled test data can be used, where pre-labeled refers to labeled images 114 and depth maps 230 of flat roads, or irregular roads, etc.", "With this data the pre-determined linear model parameters 240 may be generated.", "The electronic device 102 may determine which of the pre-determined linear model parameters 240 best fit the estimated linear model parameters 238.The road may be classified 1606 according to the road condition model that best fits the estimated linear model parameters 238.Therefore, by classifying 1606 the road, the electronic device 102 may determine the type of free space in the road image 114.FIG.", "17 illustrates certain components that may be included within an electronic device 1702.The electronic device 1702 may be or may be included within a camera, video camcorder, digital camera, cellular phone, smart phone, computer (e.g., desktop computer, laptop computer, etc.", "), tablet device, media player, television, automobile, personal camera, action camera, surveillance camera, mounted camera, connected camera, robot, aircraft, drone, unmanned aerial vehicle (UAV), healthcare equipment, gaming console, personal digital assistants (PDA), set-top box, etc.", "The electronic device 1702 includes a processor 1728.The processor 1728 may be a general purpose single- or multi-chip microprocessor (e.g., an ARM), a special purpose microprocessor (e.g., a digital signal processor (DSP)), a microcontroller, a programmable gate array, etc.", "The processor 1728 may be referred to as a central processing unit (CPU).", "Although just a single processor 1728 is shown in the electronic device 1702, in an alternative configuration, a combination of processors (e.g., an ARM and DSP) could be used.", "The electronic device 1702 also includes memory 1739.The memory 1739 may be any electronic component capable of storing electronic information.", "The memory 1739 may be embodied as random access memory (RAM), read-only memory (ROM), magnetic disk storage media, optical storage media, flash memory devices in RAM, on-board memory included with the processor, EPROM memory, EEPROM memory, registers, and so forth, including combinations thereof.", "Data 1721a and instructions 1741a may be stored in the memory 1739.The instructions 1741a may be executable by the processor 1728 to implement one or more of the methods described herein.", "Executing the instructions 1741a may involve the use of the data that is stored in the memory 1739.When the processor 1728 executes the instructions 1741, various portions of the instructions 1741b may be loaded onto the processor 1728, and various pieces of data 1721b may be loaded onto the processor 1728.The electronic device 1702 may also include a transmitter 1725 and a receiver 1727 to allow transmission and reception of signals to and from the electronic device 1702.The transmitter 1725 and receiver 1727 may be collectively referred to as a transceiver 1729.One or multiple antennas 1737a-b may be electrically coupled to the transceiver 1729.The electronic device 1702 may also include (not shown) multiple transmitters, multiple receivers, multiple transceivers and/or additional antennas.", "The electronic device 1702 may include a digital signal processor (DSP) 1731.The electronic device 1702 may also include a communications interface 1733.The communications interface 1733 may allow enable one or more kinds of input and/or output.", "For example, the communications interface 1733 may include one or more ports and/or communication devices for linking other devices to the electronic device 1702.Additionally or alternatively, the communications interface 1733 may include one or more other interfaces (e.g., touchscreen, keypad, keyboard, microphone, camera, etc.).", "For example, the communication interface 1733 may enable a user to interact with the electronic device 1702.The various components of the electronic device 1702 may be coupled together by one or more buses, which may include a power bus, a control signal bus, a status signal bus, a data bus, etc.", "For the sake of clarity, the various buses are illustrated in FIG.", "17 as a bus system 1723.In accordance with the present disclosure, a circuit, in an electronic device, may be adapted to obtain a depth map from one or more images.", "Each pixel in the depth map may have a depth value.", "The same circuit, a different circuit, or a second section of the same or different circuit may be adapted to perform vertical processing of the depth map to determine a vertical non-obstacle estimation.", "The same circuit, a different circuit, or a third section of the same or different circuit may be adapted to perform horizontal processing of the depth map to determine a horizontal non-obstacle estimation.", "The same circuit, a different circuit, or a fourth section of the same or different circuit may be adapted to combine the vertical non-obstacle estimation and the horizontal non-obstacle estimation to determine a non-obstacle map.", "In addition, the same circuit, a different circuit, or a fifth section of the same or different circuit may be adapted to control the configuration of the circuit(s) or section(s) of circuit(s) that provide the functionality described above.", "The term “determining” encompasses a wide variety of actions and, therefore, “determining” can include calculating, computing, processing, deriving, investigating, looking up (e.g., looking up in a table, a database or another data structure), ascertaining and the like.", "Also, “determining” can include receiving (e.g., receiving information), accessing (e.g., accessing data in a memory) and the like.", "Also, “determining” can include resolving, selecting, choosing, establishing and the like.", "The phrase “based on” does not mean “based only on,” unless expressly specified otherwise.", "In other words, the phrase “based on” describes both “based only on” and “based at least on.” The term “processor” should be interpreted broadly to encompass a general purpose processor, a central processing unit (CPU), a microprocessor, a digital signal processor (DSP), a controller, a microcontroller, a state machine, and so forth.", "Under some circumstances, a “processor” may refer to an application specific integrated circuit (ASIC), a programmable logic device (PLD), a field programmable gate array (FPGA), etc.", "The term “processor” may refer to a combination of processing devices, e.g., a combination of a DSP and a microprocessor, a plurality of microprocessors, one or more microprocessors in conjunction with a DSP core, or any other such configuration.", "The term “memory” should be interpreted broadly to encompass any electronic component capable of storing electronic information.", "The term memory may refer to various types of processor-readable media such as random access memory (RAM), read-only memory (ROM), non-volatile random access memory (NVRAM), programmable read-only memory (PROM), erasable programmable read-only memory (EPROM), electrically erasable PROM (EEPROM), flash memory, magnetic or optical data storage, registers, etc.", "Memory is said to be in electronic communication with a processor if the processor can read information from and/or write information to the memory.", "Memory that is integral to a processor is in electronic communication with the processor.", "The terms “instructions” and “code” should be interpreted broadly to include any type of computer-readable statement(s).", "For example, the terms “instructions” and “code” may refer to one or more programs, routines, sub-routines, functions, procedures, etc.", "“Instructions” and “code” may comprise a single computer-readable statement or many computer-readable statements.", "The functions described herein may be implemented in software or firmware being executed by hardware.", "The functions may be stored as one or more instructions on a computer-readable medium.", "The terms “computer-readable medium” or “computer-program product” refers to any tangible storage medium that can be accessed by a computer or a processor.", "By way of example, and not limitation, a computer-readable medium may comprise RAM, ROM, EEPROM, CD-ROM or other optical disk storage, magnetic disk storage or other magnetic storage devices, or any other medium that can be used to carry or store desired program code in the form of instructions or data structures and that can be accessed by a computer.", "Disk and disc, as used herein, includes compact disc (CD), laser disc, optical disc, digital versatile disc (DVD), floppy disk and Blu-ray® disc where disks usually reproduce data magnetically, while discs reproduce data optically with lasers.", "It should be noted that a computer-readable medium may be tangible and non-transitory.", "The term “computer-program product” refers to a computing device or processor in combination with code or instructions (e.g., a “program”) that may be executed, processed or computed by the computing device or processor.", "As used herein, the term “code” may refer to software, instructions, code or data that is/are executable by a computing device or processor.", "Software or instructions may also be transmitted over a transmission medium.", "For example, if the software is transmitted from a website, server, or other remote source using a coaxial cable, fiber optic cable, twisted pair, digital subscriber line (DSL), or wireless technologies such as infrared, radio and microwave, then the coaxial cable, fiber optic cable, twisted pair, DSL, or wireless technologies such as infrared, radio and microwave are included in the definition of transmission medium.", "The methods disclosed herein comprise one or more steps or actions for achieving the described method.", "The method steps and/or actions may be interchanged with one another without departing from the scope of the claims.", "In other words, unless a specific order of steps or actions is required for proper operation of the method that is being described, the order and/or use of specific steps and/or actions may be modified without departing from the scope of the claims.", "Further, it should be appreciated that modules and/or other appropriate means for performing the methods and techniques described herein, can be downloaded and/or otherwise obtained by a device.", "For example, a device may be coupled to a server to facilitate the transfer of means for performing the methods described herein.", "Alternatively, various methods described herein can be provided via a storage means (e.g., random access memory (RAM), read-only memory (ROM), a physical storage medium such as a compact disc (CD) or floppy disk, etc.", "), such that a device may obtain the various methods upon coupling or providing the storage means to the device.", "It is to be understood that the claims are not limited to the precise configuration and components illustrated above.", "Various modifications, changes and variations may be made in the arrangement, operation and details of the systems, methods, and apparatus described herein without departing from the scope of the claims." ] ]
Patent_15872672
[ [ "INDUCTION DIAGNOSTICS FOR SKIP FIRE ENGINES", "A variety of methods, diagnostic modules and other arrangements for detecting air induction faults during operation of an internal combustion engine are described.", "In some embodiments, the intake manifold pressure is monitored with the intake pressure being read for each induction opportunity.", "Induction faults may be detected based at least in part on a comparison of the manifold pressure readings for sequential induction opportunities.", "In some embodiments, an induction fault is identified when the difference between the manifold pressure associated with an induction opportunity and the immediately preceding induction opportunity exceeds an induction fault threshold." ], [ "1.A method of detecting an induction fault in an internal combustion engine having an intake manifold that supplies air to at least one working chamber of the internal combustion engine, and an intake manifold pressure sensor configured to sense an air pressure within the intake manifold, the method comprising: obtaining a first pressure reading indicative of the intake manifold pressure at a time associated with a first working chamber air induction opportunity; obtaining a second pressure reading indicative of the intake manifold pressure at a time associated with a second working chamber air induction opportunity that follows the first working chamber induction opportunity, the second air induction opportunity being the next air induction opportunity following the first air induction opportunity; and determining whether an induction fault has occurred in association with the second air induction opportunity based at least in part on the first and second pressure readings.", "2.A method as recited in claim 1 further comprising: determining a difference between the first and second pressure readings; comparing the difference to a threshold; and identifying an induction fault for the second air induction opportunity when the difference is beyond the threshold.", "3.A method as recited in claim 1 wherein each pressure reading is based on a plurality of pressure measurement samples.", "4.A method as recited in claim 1 wherein each pressure reading is made at substantially the same phase in a working cycle associated with its associated induction opportunity.", "5.A method as recited in claim 4 wherein each pressure reading is made: during an associated intake stroke of a piston in an associated working chamber in which the associated working cycle occurs; and within a range of 150 degrees±30 degrees of crankshaft rotation after top dead center of the piston in the associated intake stroke.", "6.A method as recited in claim 1 wherein the threshold is based at least in part on how many air induction opportunities were skipped immediately before the second air induction opportunity.", "7.A method as recited in claim 1 wherein the threshold is based at least in part on an intake manifold pressure ratio, wherein the intake manifold pressure ratio is a ratio of intake manifold pressure to barometric pressure.", "8.A method as recited in claim 1 wherein the threshold is based at least in part on a current operational firing fraction of the engine.", "9.A method as recited in claim 1 wherein the threshold is based at least in part on a current engine speed.", "10.A method as recited in claim 1 performed while the engine is operating in a multi-charge level operational mode.", "11.A method as recited in claim 1 performed while the engine is operating in a skip fire operational mode.", "12.An induction fault lookup table embodied in a computer readable medium associated with an engine controller for use in identifying air induction faults, the induction fault lookup table comprising: a multiplicity of entries that identify induction fault thresholds, and wherein the induction fault lookup table includes at least one index selected from the group consisting of (i) a number of skipped induction opportunities that immediately preceded a current induction opportunity, (ii) an intake manifold pressure ratio, (iii) an operational firing fraction, and (iv) an engine speed.", "13.An induction fault lookup table as recited in claim 12 wherein the induction fault lookup table includes at least two indices selected from the group consisting of (i) the number of skipped induction opportunities that immediately preceded a current induction opportunity, (ii) the intake manifold pressure ratio, (iii) the operational firing fraction, and (iv) the engine speed.", "14.An induction fault lookup table as recited in claim 12 wherein the induction fault lookup table is a multi-dimensional lookup table having both (i) the number of skipped induction opportunities that immediately preceded a current induction opportunity, and (ii) the intake manifold pressure ratio as indices.", "15.An induction fault lookup table as recited in claim 12 wherein an additional index for the lookup table is selected from the group consisting of: a skip frequency indicative of a number of induction skips that are expected to occur in a designated period of time; a throttle position; intake manifold pressure; cam phase; boost pressure; intake valve lift profile; and skip/induct decision for a next firing opportunity.", "16.An induction fault lookup table as recited in claim 12 composed of first and second lookup table segments, wherein: a first index for the first lookup table segment is intake manifold pressure ratio; a second index for the first lookup table segment is engine speed; a first index for the second lookup table segment is firing fraction; and a second index for the second lookup table segment is the number of skipped induction opportunities that immediately precede the current induction opportunity; and wherein values retrieved from the first and second lookup tables segments are summed to determine to provide a composite induction fault threshold.", "17.A diagnostics module configured to detect induction faults that occur during operation of an internal combustion engine that includes an intake manifold that supplies air to at least one working chamber of the internal combustion engine, and an intake manifold pressure sensor configured to sense an air pressure within the intake manifold, the diagnostic module comprising a controller configured to: obtain a first pressure reading indicative of the intake manifold pressure at a time associated with a first working chamber induction opportunity that has the potential to draw air from the intake manifold; obtain a second pressure reading indicative of the intake manifold pressure at a time associated with a second working chamber induction opportunity that has the potential to draw air from the intake manifold, the second working chamber induction opportunity being the next working chamber induction opportunity following the first working chamber induction opportunity; and determine whether an induction fault has occurred in association with the second working chamber induction opportunity based at least in part on the first and second pressure readings.", "18.A diagnostics module as recited in claim 17 further comprising an induction fault lookup table embodied in a computer readable medium associated with the controller for use in identifying induction faults, the induction fault lookup table comprising a multiplicity of entries that identify induction fault thresholds used in the determination of whether an induction fault has occurred, wherein different entries in the induction fault lookup table correspond to thresholds suitable for use under different operating conditions.", "19.A diagnostics module as recited in claim 18 wherein the induction fault lookup table includes at least one index selected from the group consisting of (i) a number of skipped induction opportunities that immediately preceded the second working chamber induction opportunity, (ii) an intake manifold pressure ratio, or (iii) an operational firing fraction.", "20.A diagnostics module as recited in claim 18 wherein the controller is further configured to: determine a difference between the first and second pressure readings; compare the difference to a threshold; and identifying an induction fault for the second induction opportunity when the difference exceeds the threshold.", "21.A diagnostics module as recited in claim 18 wherein the controller is further configured to make a pressure reading at substantially the same phase in each working cycle.", "22.An engine controller comprising the diagnostics module as recited in claim 17 and a skip fire controller configured to direct operation of an engine in a skip fire operational mode and wherein: the diagnostic module is configured to detect induction faults during skip fire operation of the engine.", "23.An engine controller comprising the diagnostics module as recited in claim 17 and a cylinder output level modulation controller configured to direct operation of an engine in a cylinder output level modulation operational mode and wherein: the diagnostic module is configured to detect induction faults during cylinder output level modulation operation of the engine." ], [ "<SOH> BACKGROUND <EOH>Most vehicles in operation today are powered by internal combustion (IC) engines.", "Internal combustion engines typically have multiple cylinders or other working chambers where combustion occurs.", "The power generated by the engine depends on the amount of fuel and air that is delivered to each working chamber.", "Fuel efficiency of internal combustion engines can be substantially improved by varying the engine displacement.", "This allows for the full torque to be available when required, yet can significantly reduce pumping losses and improve thermal efficiency by using a smaller displacement when full torque is not required.", "The most common method today of implementing a variable displacement engine is to deactivate a group of cylinders substantially simultaneously.", "In this approach the intake and exhaust valves associated with the deactivated cylinders are kept closed and no fuel is injected when it is desired to skip a combustion event.", "For example, an 8 cylinder variable displacement engine may deactivate half of the cylinders (i.e.", "4 cylinders) so that it is operating using only the remaining 4 cylinders.", "Commercially available variable displacement engines available today typically support only two or at most three displacements.", "Another engine control approach that varies the effective displacement of an engine is referred to as “skip fire” engine control.", "In general, skip fire engine control contemplates selectively skipping the firing of certain cylinders during selected firing opportunities.", "Thus, a particular cylinder may be fired during one engine cycle and then skipped during the next engine cycle and selectively skipped or fired during the next.", "In this manner, even finer control of the effective engine displacement is possible.", "For example, firing every third cylinder in a 4 cylinder engine would provide an effective reduction to ⅓ rd of the full engine displacement, which is a fractional displacement that is not obtainable by simply deactivating a set of cylinders to create an even firing pattern.", "Similarly, firing every other cylinder in a 3 cylinder engine would provide an effective displacement of ½, which is not obtainable by simply deactivating a set of cylinders.", "Conceptually, virtually any effective displacement can be obtained using skip fire control, although in practice most implementations restrict operation to a set of available firing fractions, sequences or patterns.", "The Applicant, Tula Technology, Inc., has filed a number of patents describing various approaches to skip fire control.", "By way of example, U.S. Pat.", "Nos.", "8,099,224; 8,464,690; 8,651,091; 8,839,766; 8,869,773; 9,020,735; 9,086,020; 9,120,478; 9,175,613; 9,200,575; 9,200,587; 9,291,106; 9,399,964, and others describe a variety of engine controllers that make it practical to operate a wide variety of internal combustion engines in a dynamic skip fire operational mode.", "Each of these patents and patent applications is incorporated herein by reference.", "U.S. Pat.", "No.", "8,131,445 (which is incorporated herein by reference) teaches a continuously variable displacement engine using a dynamic skip fire operational approach, which allows any fraction of the cylinders to be fired on average using individual cylinder deactivation.", "In a continuously variable displacement mode operated in skip-fire, the amount of torque delivered generally depends heavily on the firing fraction, or fraction of combustion events that are not skipped.", "In other skip fire approaches a particular firing pattern or firing fraction may be selected from a set of available firing patterns or fractions.", "In some applications referred to as multi-level skip fire, individual working cycles that are fired may be purposely operated at different cylinder outputs levels—that is, using purposefully different air charge and corresponding fueling levels.", "By way of example, U.S. Pat.", "No.", "9,399,964 (which is incorporated herein by reference) describes some such approaches.", "The individual cylinder control concepts used in dynamic skip fire can also be applied to dynamic multi-charge level engine operation in which all cylinders are fired, but individual working cycles are purposely operated at different cylinder output levels.", "Dynamic skip fire and dynamic multi-charge level engine operation may collectively be considered different types of cylinder output level modulation engine operation in which the output of each working cycle (e.g., skip/fire, high/low, skip/high/low, etc.)", "is dynamically determined during operation of the engine, typically on an individual cylinder working cycle by working cycle (firing opportunity by firing opportunity) basis.", "It should be appreciated that cylinder output level engine operation is different than conventional variable displacement in which when the engine enters a reduced displacement operational state, a defined set of cylinders are operated in generally the same manner until the engine transitions to a different operational state.", "In order to operate with dynamic skip fire control or other types of cylinder output level modulation, it is necessary to control the intake and exhaust valves in a more complex manner than if the cylinders are always activated.", "For example, in skip fire operation, the intake and/or exhaust valves remain closed during a skipped working cycle to minimize pumping losses.", "This contrasts with an engine operating on all cylinders, where the intake and exhaust valves open and close on every working cycle.", "Most vehicles in operation today use a camshaft to open and close the intake valves.", "The valve train may incorporate a cam phaser to control the timing of the valve opening and closing relative to the crankshaft.", "Some cam operated engines also have adjustable valve lift.", "For example, some engines have mechanisms to shift valves between a “high lift” and “low lift” level; for example, a maximum lift of 11 mm for “high lift” and of 4 mm for “low lift”.", "As an alternative to cam controlled valves, some engines use electronic valve actuation, which has more flexibility in the valve opening and closing because the valve motion is not constrained by camshaft rotation.", "For cam operated valves a method to deactivate a valve is to incorporate a collapsible valve lifter into the valve train.", "To activate the valve the lifter remains at its full extension and to deactivate the valve the lifter collapses failing to transfer the cam lobe profile to the valve.", "Valve activation/deactivation is controlled by a solenoid which deactivates the valve by providing high pressure oil to the collapsible lifter.", "Other mechanisms exist to deactivate valves in engines with cam operated valves.", "U.S. Pat.", "Nos.", "9,175,613, 9,581,097, and 9,562,470, each of which is incorporated herein by reference in their entireties, teach methods of sensing failures of an exhaust valve to open after a combustion event.", "As pointed out in these applications, failure of the exhaust valve to open will result in high pressure combustion gases being trapped in the cylinder, which can lead to damage of the intake valve and its associated mechanism if it attempts to open against this high pressure.", "Failures of an intake valve to activate or deactivate under skip fire control can also have a deleterious impact on engine operation.", "Failure of the intake valve to open will result in missing a planned firing event.", "This may lead to unburnt hydrocarbons being transmitted to the engine exhaust and may result in unacceptable emissions.", "There will also be a loss of engine torque and increased engine roughness.", "Failure of an intake valve to close may result in increased pumping losses and excess oxygen in the exhaust gases deleteriously impacting the catalytic converter.", "Failures in the cam adjustment mechanism can also lead to emission and engine performance issues.", "In all cases information regarding intake valve or cam failures may be required to be communicated to a vehicle on-board diagnostic (OBD) system to satisfy governmental regulations, such as those imposed by the California Air Resources Board (CARB).", "It is thus desirable to make a determination of whether actual cylinder air induction accurately matches the commanded operation." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>A variety of methods, diagnostic modules and other arrangements for detecting air induction faults during operation of an internal combustion engine are described.", "In some embodiments, the intake manifold pressure is monitored with the intake pressure being read for each induction opportunity.", "Induction faults may be detected based at least in part on a comparison of the manifold pressure readings for sequential induction opportunities.", "In some embodiments, an induction fault is identified when the difference between the manifold pressure associated with an induction opportunity and the immediately preceding induction opportunity exceeds an induction fault threshold.", "In some embodiments, the induction fault threshold is based at least in part on at least one of: (i) how many air induction opportunities were skipped immediately before the current air induction opportunity; (ii) an intake manifold pressure ratio; (iii) a current operational firing fraction of the engine; and (iv) a current engine speed.", "In some embodiments, a lookup table may be used to identify the induction fault threshold suitable for use under current operating conditions.", "In some embodiments, each manifold pressure reading is based on a plurality of pressure measurement samples.", "In some embodiments, each manifold pressure reading is made at substantially the same phase in a working cycle associated with its associated induction opportunity.", "In some embodiments, the manifold pressure reading as made at a phase that is in the range of 120° to 180° after top dead center of the piston in the associated intake stroke—as for example, near 150° after top dead center.", "The describe approaches are particularly well suited for use in engines operating in a skip fire mode with cylinder deactivation and/or other dynamic cylinder output level modulation modes.", "A variety of different induction faults can be detected using the described techniques including intake valve activation failures, intake valve deactivation failures, and valve lift faults (e.g., valve lift too low and/or valve lift too high induction faults).", "Once and induction fault is identified, it may be acted on in any appropriate manners.", "In some embodiments, the fault is logged in a diagnostic fault log.", "When appropriate, the control of the engine can be varied based on detected fault, as for example, by avoiding use of a cylinder that is consistently faulting or by disabling skip fire operation of the engine until the problem is fixed.", "In another aspect, various specific induction fault lookup tables are described.", "The induction fault tables may be embodied in a computer readable medium associated with an engine controller for use in identifying air induction faults.", "In some embodiments, the induction fault lookup table include a multiplicity of entries that identify induction fault thresholds.", "Indices for the lookup table may include one or more of: (i) a number of skipped induction opportunities that immediately preceded a current induction opportunity, (ii) an intake manifold pressure ratio, (iii) an operational firing fraction, and (iv) an engine speed.", "In other embodiments, the an additional index for the lookup table may include one of: (v) a skip frequency indicative of a number of induction skips that are expected to occur in a designated period of time; (vi) a throttle position; (vii) the intake manifold pressure; (vii) cam phase; (viii) the intake valve lift profile; (ix) boost pressure; and the skip/fire decision for the next firing opportunity.", "In some embodiments that induction fault lookup table may be a composite table formed from a plurality of lookup table segments.", "A variety of diagnostic modules capable of performing the functions described above are also described." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a Continuation-in-Part of U.S. application Ser.", "No.", "15/641,097, filed Jul.", "3, 2017, which is a Divisional of U.S. application Ser.", "No.", "14/919,385 (now U.S. Pat.", "No.", "9,835,522), filed Oct. 21, 2015, which claims priority of Provisional Application No.", "62/067,873 filed on Oct. 23, 2014.Each of the foregoing applications is incorporated herein by reference in its entirety.", "FIELD The present invention relates generally to methods and mechanisms for diagnosing induction faults in an internal combustion engine.", "Various embodiments involve measurement and analysis of the intake manifold pressure and/or crankshaft angular acceleration to diagnose induction faults.", "BACKGROUND Most vehicles in operation today are powered by internal combustion (IC) engines.", "Internal combustion engines typically have multiple cylinders or other working chambers where combustion occurs.", "The power generated by the engine depends on the amount of fuel and air that is delivered to each working chamber.", "Fuel efficiency of internal combustion engines can be substantially improved by varying the engine displacement.", "This allows for the full torque to be available when required, yet can significantly reduce pumping losses and improve thermal efficiency by using a smaller displacement when full torque is not required.", "The most common method today of implementing a variable displacement engine is to deactivate a group of cylinders substantially simultaneously.", "In this approach the intake and exhaust valves associated with the deactivated cylinders are kept closed and no fuel is injected when it is desired to skip a combustion event.", "For example, an 8 cylinder variable displacement engine may deactivate half of the cylinders (i.e.", "4 cylinders) so that it is operating using only the remaining 4 cylinders.", "Commercially available variable displacement engines available today typically support only two or at most three displacements.", "Another engine control approach that varies the effective displacement of an engine is referred to as “skip fire” engine control.", "In general, skip fire engine control contemplates selectively skipping the firing of certain cylinders during selected firing opportunities.", "Thus, a particular cylinder may be fired during one engine cycle and then skipped during the next engine cycle and selectively skipped or fired during the next.", "In this manner, even finer control of the effective engine displacement is possible.", "For example, firing every third cylinder in a 4 cylinder engine would provide an effective reduction to ⅓rd of the full engine displacement, which is a fractional displacement that is not obtainable by simply deactivating a set of cylinders to create an even firing pattern.", "Similarly, firing every other cylinder in a 3 cylinder engine would provide an effective displacement of ½, which is not obtainable by simply deactivating a set of cylinders.", "Conceptually, virtually any effective displacement can be obtained using skip fire control, although in practice most implementations restrict operation to a set of available firing fractions, sequences or patterns.", "The Applicant, Tula Technology, Inc., has filed a number of patents describing various approaches to skip fire control.", "By way of example, U.S. Pat.", "Nos.", "8,099,224; 8,464,690; 8,651,091; 8,839,766; 8,869,773; 9,020,735; 9,086,020; 9,120,478; 9,175,613; 9,200,575; 9,200,587; 9,291,106; 9,399,964, and others describe a variety of engine controllers that make it practical to operate a wide variety of internal combustion engines in a dynamic skip fire operational mode.", "Each of these patents and patent applications is incorporated herein by reference.", "U.S. Pat.", "No.", "8,131,445 (which is incorporated herein by reference) teaches a continuously variable displacement engine using a dynamic skip fire operational approach, which allows any fraction of the cylinders to be fired on average using individual cylinder deactivation.", "In a continuously variable displacement mode operated in skip-fire, the amount of torque delivered generally depends heavily on the firing fraction, or fraction of combustion events that are not skipped.", "In other skip fire approaches a particular firing pattern or firing fraction may be selected from a set of available firing patterns or fractions.", "In some applications referred to as multi-level skip fire, individual working cycles that are fired may be purposely operated at different cylinder outputs levels—that is, using purposefully different air charge and corresponding fueling levels.", "By way of example, U.S. Pat.", "No.", "9,399,964 (which is incorporated herein by reference) describes some such approaches.", "The individual cylinder control concepts used in dynamic skip fire can also be applied to dynamic multi-charge level engine operation in which all cylinders are fired, but individual working cycles are purposely operated at different cylinder output levels.", "Dynamic skip fire and dynamic multi-charge level engine operation may collectively be considered different types of cylinder output level modulation engine operation in which the output of each working cycle (e.g., skip/fire, high/low, skip/high/low, etc.)", "is dynamically determined during operation of the engine, typically on an individual cylinder working cycle by working cycle (firing opportunity by firing opportunity) basis.", "It should be appreciated that cylinder output level engine operation is different than conventional variable displacement in which when the engine enters a reduced displacement operational state, a defined set of cylinders are operated in generally the same manner until the engine transitions to a different operational state.", "In order to operate with dynamic skip fire control or other types of cylinder output level modulation, it is necessary to control the intake and exhaust valves in a more complex manner than if the cylinders are always activated.", "For example, in skip fire operation, the intake and/or exhaust valves remain closed during a skipped working cycle to minimize pumping losses.", "This contrasts with an engine operating on all cylinders, where the intake and exhaust valves open and close on every working cycle.", "Most vehicles in operation today use a camshaft to open and close the intake valves.", "The valve train may incorporate a cam phaser to control the timing of the valve opening and closing relative to the crankshaft.", "Some cam operated engines also have adjustable valve lift.", "For example, some engines have mechanisms to shift valves between a “high lift” and “low lift” level; for example, a maximum lift of 11 mm for “high lift” and of 4 mm for “low lift”.", "As an alternative to cam controlled valves, some engines use electronic valve actuation, which has more flexibility in the valve opening and closing because the valve motion is not constrained by camshaft rotation.", "For cam operated valves a method to deactivate a valve is to incorporate a collapsible valve lifter into the valve train.", "To activate the valve the lifter remains at its full extension and to deactivate the valve the lifter collapses failing to transfer the cam lobe profile to the valve.", "Valve activation/deactivation is controlled by a solenoid which deactivates the valve by providing high pressure oil to the collapsible lifter.", "Other mechanisms exist to deactivate valves in engines with cam operated valves.", "U.S. Pat.", "Nos.", "9,175,613, 9,581,097, and 9,562,470, each of which is incorporated herein by reference in their entireties, teach methods of sensing failures of an exhaust valve to open after a combustion event.", "As pointed out in these applications, failure of the exhaust valve to open will result in high pressure combustion gases being trapped in the cylinder, which can lead to damage of the intake valve and its associated mechanism if it attempts to open against this high pressure.", "Failures of an intake valve to activate or deactivate under skip fire control can also have a deleterious impact on engine operation.", "Failure of the intake valve to open will result in missing a planned firing event.", "This may lead to unburnt hydrocarbons being transmitted to the engine exhaust and may result in unacceptable emissions.", "There will also be a loss of engine torque and increased engine roughness.", "Failure of an intake valve to close may result in increased pumping losses and excess oxygen in the exhaust gases deleteriously impacting the catalytic converter.", "Failures in the cam adjustment mechanism can also lead to emission and engine performance issues.", "In all cases information regarding intake valve or cam failures may be required to be communicated to a vehicle on-board diagnostic (OBD) system to satisfy governmental regulations, such as those imposed by the California Air Resources Board (CARB).", "It is thus desirable to make a determination of whether actual cylinder air induction accurately matches the commanded operation.", "SUMMARY OF THE INVENTION A variety of methods, diagnostic modules and other arrangements for detecting air induction faults during operation of an internal combustion engine are described.", "In some embodiments, the intake manifold pressure is monitored with the intake pressure being read for each induction opportunity.", "Induction faults may be detected based at least in part on a comparison of the manifold pressure readings for sequential induction opportunities.", "In some embodiments, an induction fault is identified when the difference between the manifold pressure associated with an induction opportunity and the immediately preceding induction opportunity exceeds an induction fault threshold.", "In some embodiments, the induction fault threshold is based at least in part on at least one of: (i) how many air induction opportunities were skipped immediately before the current air induction opportunity; (ii) an intake manifold pressure ratio; (iii) a current operational firing fraction of the engine; and (iv) a current engine speed.", "In some embodiments, a lookup table may be used to identify the induction fault threshold suitable for use under current operating conditions.", "In some embodiments, each manifold pressure reading is based on a plurality of pressure measurement samples.", "In some embodiments, each manifold pressure reading is made at substantially the same phase in a working cycle associated with its associated induction opportunity.", "In some embodiments, the manifold pressure reading as made at a phase that is in the range of 120° to 180° after top dead center of the piston in the associated intake stroke—as for example, near 150° after top dead center.", "The describe approaches are particularly well suited for use in engines operating in a skip fire mode with cylinder deactivation and/or other dynamic cylinder output level modulation modes.", "A variety of different induction faults can be detected using the described techniques including intake valve activation failures, intake valve deactivation failures, and valve lift faults (e.g., valve lift too low and/or valve lift too high induction faults).", "Once and induction fault is identified, it may be acted on in any appropriate manners.", "In some embodiments, the fault is logged in a diagnostic fault log.", "When appropriate, the control of the engine can be varied based on detected fault, as for example, by avoiding use of a cylinder that is consistently faulting or by disabling skip fire operation of the engine until the problem is fixed.", "In another aspect, various specific induction fault lookup tables are described.", "The induction fault tables may be embodied in a computer readable medium associated with an engine controller for use in identifying air induction faults.", "In some embodiments, the induction fault lookup table include a multiplicity of entries that identify induction fault thresholds.", "Indices for the lookup table may include one or more of: (i) a number of skipped induction opportunities that immediately preceded a current induction opportunity, (ii) an intake manifold pressure ratio, (iii) an operational firing fraction, and (iv) an engine speed.", "In other embodiments, the an additional index for the lookup table may include one of: (v) a skip frequency indicative of a number of induction skips that are expected to occur in a designated period of time; (vi) a throttle position; (vii) the intake manifold pressure; (vii) cam phase; (viii) the intake valve lift profile; (ix) boost pressure; and the skip/fire decision for the next firing opportunity.", "In some embodiments that induction fault lookup table may be a composite table formed from a plurality of lookup table segments.", "A variety of diagnostic modules capable of performing the functions described above are also described.", "BRIEF DESCRIPTION OF THE DRAWINGS The invention and the advantages thereof, may best be understood by reference to the following description taken in conjunction with the accompanying drawings in which: FIG.", "1 is a schematic diagram showing a portion of one cylinder of an internal combustion engine.", "FIG.", "2 is a representative plot of valve lift versus crankshaft angle.", "FIG.", "3 is a representative plot of cylinder mass air charge (MAC) versus cam angle for a high lift and low lift valve schedule.", "FIG.", "4 is a block diagram of an engine controller and an induction fault detection unit according to a particular embodiment of the present invention.", "FIG.", "5A is a representative plot of intake manifold absolute pressure (MAP) and firing enable signal versus time during normal skip fire operation.", "FIG.", "5B is a representative plot of intake manifold absolute pressure (MAP) and firing enable signal versus time during an induction fault.", "FIG.", "6 is a block diagram of a diagnostic filter circuit according to a particular embodiment of the present invention.", "FIG.", "7A is a representative plot of an output of a diagnostic filter according to an embodiment of the present invention.", "FIG.", "7B is a representative plot of an output signal indicating an induction fault according to an embodiment of the present invention.", "FIG.", "8 is a block diagram of a system to produce an output signal indicative of induction faults according to an embodiment of the present invention.", "FIG.", "9 is a representative plot of the torque absorbed and produced by a cylinder under test over an engine cycle for different types of induction events.", "FIG.", "10 is a representative plot of the calculated crankshaft jerk induced by a cylinder under test over an engine cycle for different types of induction events.", "FIGS.", "11A-11E are a series of graphs illustrating variations in manifold pressure that may occur during skip fire operation at a firing fraction of ⅓ and the generation of a fault signal based thereon.", "FIGS.", "11F-11J are a series of graphs illustrating variations in manifold pressure that may occur during skip fire operation at a firing fraction of ⅘ and the generation of a fault signal based thereon.", "FIG.", "12 is a flow chart illustrating a method of detecting induction faults in accordance with another embodiment.", "FIGS.", "13A and 13B are induction fault threshold lookup tables suitable for use in determining an induction fault in accordance with an embodiment.", "The table of FIG.", "13A utilizes intake manifold pressure ratio and engine speed as indices.", "The table of FIG.", "13B utilizes firing fraction and the number of skipped induction events that immediately preceded the current induction as indices.", "In the drawings, like reference numerals are sometimes used to designate like structural elements.", "It should also be appreciated that the depictions in the figures are diagrammatic and not to scale.", "DETAILED DESCRIPTION The present invention is a method and apparatus to determine failures of air induction in an internal combustion engine.", "Induction failures may arise from intake valve activation or deactivation failures or improper response to valve lift commands.", "The invention is particularly useful for skip fire controlled internal combustion engines because of the frequent cylinder activation/deactivation inherent in skip fire operation.", "In some embodiments an algorithm uses intake manifold absolute pressure to determine if an intake valve has been actuated properly according to its commanded state.", "In other embodiments an algorithm uses intake manifold absolute pressure to determine if the cam valve lift setting has been actuated properly according to its commanded state.", "In other embodiments the same functions can be determined using measurement of the crankshaft angular acceleration or time derivatives thereof.", "In still further embodiments these methods can be combined to provide a more robust diagnostic.", "The diagnostic techniques described herein improve engine efficiency, reduce noxious emissions and lower the risks of degradation to engine components.", "The techniques are able to detect a fault in the same engine cycle that it occurs and determine which cylinder has the fault.", "In general, dynamic skip fire engine control contemplates selectively skipping the firing of certain cylinders during selected firing opportunities.", "Thus, for example, a particular cylinder may be fired during one firing opportunity and then may be skipped during the next firing opportunity and then selectively skipped or fired during the next.", "The fire/skip decision may be made on a firing opportunity by firing opportunity basis and the firing controller typically includes an accumulator functionality that tracks the portion of a firing that has been requested but not yet delivered, or delivered, but not yet requested.", "This decision is typically made some number of firing opportunities prior to the firing event to allow the control system time to correctly schedule the engine for either a skip or fire event.", "Skip fire control contrasts with conventional variable displacement engine operation in which a fixed set of the cylinders are deactivated during certain low-load operating conditions.", "When a cylinder is deactivated in a variable displacement engine, its piston typically still reciprocates, however neither air nor fuel is delivered to the cylinder so the piston does not deliver any net power over an engine cycle.", "Since the cylinders that are “deactivated” do not deliver power, the proportionate load on the remaining cylinders is increased, thereby allowing the remaining cylinders to operate at an improved thermodynamic efficiency.", "With skip fire control, cylinders are also preferably deactivated during skipped working cycles in the sense that air is not pumped through the cylinder and no fuel is delivered during skipped working cycles.", "This requires a valve deactivation mechanism where the intake and exhaust valves of a cylinder remain closed during a working cycle.", "In this case, no air is inducted into the deactivated cylinders during the skipped working cycles thereby reducing pumping losses.", "FIG.", "1 illustrates a cylinder of an internal combustion engine 110 that includes a cylinder 161, a piston 163, an intake manifold 165, spark plug 190, and spark gap 191 and an exhaust manifold 169.A throttle valve 171 controls the inflow of air from an air filter or other air source into the intake manifold.", "Air is inducted from the intake manifold 165 into cylinder 161 through an intake valve 185.Fuel is added to this air either by port injection or direct injection into the cylinder (not shown in FIG.", "1).", "Combustion of the air/fuel mixture is initiated by a spark present in the spark gap 191.Expanding gases from combustion increase the pressure in the cylinder and drive the piston 163 down.", "Reciprocal linear motion of the piston is converted into rotational motion by a connecting rod 189, which is connected to a crankshaft 183.Combustion gases are vented from cylinder 161 through an exhaust valve 187.A camshaft (not shown in FIG.", "1) may be used to move the intake and exhaust valves synchronously with the crankshaft rotation.", "The rotating camshaft regulates opening and closing of the intake and exhaust valves.", "The camshaft includes cam lobes that each have a profile, which is associated with a valve lift schedule.", "The valve lift schedule includes an amount of time a valve is open (i.e.", "duration) and a magnitude or degree to which the valve opens (i.e.", "lift).", "Valve phasing relative to the crankshaft may be controlled by a cam phaser (not shown in FIG.", "1).", "Some engines employ valve trains that allow for variable valve lift.", "The valve lift may be either continuously controlled or step-wise selectable, for example two or three steps.", "Variable lift on the intake valve can reduce pumping losses and can facilitate improved combustion through better air/fuel gas dynamics.", "FIG.", "2 illustrates the valve lift profile associated with a two step valve schedule.", "Curves 202 and 204 illustrate an exhaust valve lift profile associated with extremes of exhaust valve timing phase adjustment.", "Curves 206 and 208 illustrate an intake valve lift profile associated with extremes of intake valve timing phase adjustment for the “high lift” schedule.", "Curves 210 and 212 illustrate the intake valve lift profile associated with extremes of intake valve timing phase adjustment for the “low lift” schedule.", "The solid curves, 202, 206, and 210 represent the valve lift profile associated with maximum cam phaser advance.", "The dashed curves 204, 208, and 212 represent the valve lift profile associated with maximum cam phaser retardation.", "FIG.", "3 illustrates the resultant amounts of air induction for different cam phaser and valve lift schedules.", "Generally, the “low lift” schedule 222 inducts less air into a cylinder than the “high lift” schedule 224.This difference in the amount of inducted air 226 can be detected using the diagnostics described herein.", "The amount of inducted air will also vary with the MAP and engine speed.", "Changes in the inducted air mass, i.e.", "mass air charge (MAC), will impact the intake manifold pressure and the crankshaft angular acceleration.", "These changes can be sensed by the diagnostic apparatus and methods described herein and used to determine whether the amount of inducted air substantially matches the commanded values.", "If the measured values deviate by more than a prescribed threshold, a fault signal may be generated.", "Referring to FIG.", "4, an engine controller 100 according to a particular embodiment of the present invention will be described.", "The engine controller 100 includes a firing fraction calculator 112, a firing timing determination module 120, an engine control unit 140, and an induction fault detection unit 102.Initially, the firing fraction calculator 112 receives an input signal that is treated as a request for a desired engine output.", "The firing fraction calculator 112 is arranged to determine a firing fraction, firing sequence, firing pattern or firing density that would be appropriate to deliver the desired output under selected operating conditions.", "The firing fraction is indicative of the fraction or percentage of firings under the current (or directed) operating conditions that are required to deliver the desired output.", "The firing fraction calculator generates a commanded firing fraction 113, which is received by the firing timing determination module 120 and the induction failure detection unit 102.The firing timing determination module 120 is arranged to issue a sequence of firing commands (e.g., drive pulse signal 115) that cause the engine to deliver the percentage of firings dictated by the commanded firing fraction 113.The sequence of firing commands output by the firing timing determining module 120 is passed to an engine control unit (ECU) 140 which orchestrates the actual firings.", "The firing timing determination module 120 is arranged to deliver a wide variety of firing information to the induction fault detection unit 102.This may include, but is not limited to, the drive pulse signal 115 or a firing sequence, a firing decision for a particular working chamber, a signal indicating the number or identity of that working chamber, and/or the firing history of a selected working chamber.", "In various applications, this information can be directly sent between the induction fault detection unit 102 and the firing timing determination module 120 or the induction fault detection unit 102 may be able to infer this information.", "For example, if the firing timing determination module 120 sends a fire/skip signal to the induction fault detection unit 102 additional information on the cam schedule and phase may be sent over signal lines 161 and 162.These two pieces of information, the fire/skip decision and the valve schedule would allow the induction fault detection unit 102 to determine which cylinder is being fired/skipped and the expected MAC associated with the firing opportunity (should it be a fire).", "The induction failure detection unit 102 may include a delay block 143, which compensates for delays between the commanded valve actuation signal 115 and/or signal 113 and the actual valve movement.", "In should be appreciated that the engine controller shown in FIG.", "4 can be configured in multiple ways; for example the induction failure detection unit 102 may be integrated into engine controller 100.An advantage of many skip fire engine approaches is that information about future firing decisions is known before the firings actually take place.", "Various implementations of the present invention take advantage of this feature.", "More specifically, firing information is used in a wide variety of ways to estimate the anticipated fluctuations in the MAP and/or crank acceleration.", "Comparison can then be made whether the observed fluctuations are consistent with the estimated fluctuations.", "If the observed fluctuations exceed a defined range from the estimated fluctuation a fault indication may result.", "The induction failure detection unit 102 can be used to detect faults in the intake valves and valve lift level.", "Although the present invention contemplates the use of dynamic skip fire engine control, this should not be considered limiting.", "The invention may be used in an engine operating on all cylinders or a variable displacement engine, i.e.", "fixed displacement levels.", "These control systems generally have more evenly spaced induction events than a skip fire controlled engine, although the amount of inducted air may vary more than in skip fire control.", "The assignee of the present application has filed multiple patent applications on a wide variety of skip fire and other engine designs, such as U.S. Pat.", "Nos.", "7,954,474; 7,886,715; 7,849,835; 7,577,511; 8,099,224; 8,131,445; and U.S. Pat.", "Nos.", "8,131,447; 8,616,181; 8,701,628; 9,120,478, 9,200,587, 9,239,037, 9,273,643 and 9,650,971, each of which is incorporated herein by reference in its entirety for all purposes.", "Many of the aforementioned applications describe firing controllers, firing fraction calculators, filters, power train parameter adjusting modules, firing timing determining modules, and other mechanisms that may be integrated into or connected with the engine controller 100 and the induction failure detection unit 102.Intake Manifold Pressure Based Diagnostics In some embodiments an algorithm using information on the intake manifold absolute pressure (MAP) can be used to determine induction faults.", "The variations in the MAP may result from the superposition of multiple components: (1) a possibly steady slowly varying average manifold pressure used to regulate average cylinder charge, (2) a slowly varying component reflecting driver input or—in the case of a skip firing engine, the faster increase and decay of average manifold pressure in response to firing density changes, (3) higher frequency waves that are intake manifold natural resonances excited by separate inductions, much as a bell is excited by separate blows, and finally (4) waves excited by individual inductions or missing inductions.", "FIG.", "5A plots the measured MAP over a number of firing opportunities for an eight cylinder engine operating in skip fire mode at 1250 rpm and a firing fraction of ⅔.", "A firing fraction of ⅔ results in a fire-fire-skip-fire .", ".", ".", "pattern evident as the high to low variation in the fire enable signal 502.The measured MAP may be determined by one or more pressure sensors situated in an intake manifold.", "The MAP sensor(s) have a natural bandwidth of greater than 1 kHz.", "FIG.", "5A shows a regular pattern in the measured MAP 504.Induction of air into a cylinder during a firing event results in a MAP drop.", "Conversely, the absence of air induction, associated with a cylinder skip, results in a MAP increase during a skipped induction event.", "If an engine is operating with a regular firing pattern like that shown in FIG.", "5A, an induction failure will be evident as a deviation from that pattern.", "FIG.", "5B shows the same operating conditions as in FIG.", "5A except that a cylinder failed to deactivate during a commanded skip event 510.Instead of rising, there is a continued drop in MAP 512.This break in the MAP signal pattern can be detected and used as an induction fault diagnostic.", "FIG.", "6 shows a diagnostic filter 600 that may be used to separate low frequency MAP signal components (1) and (2) from higher frequency components (3) and (4).", "The filtered output 608 has substantially reduced the low frequency signal components compared to the MAP signal input 612.Removing the low frequency components makes subsequent diagnostic thresholding and logic simpler, as their time scale is far different than signals caused by (3) or (4).", "The last component (4) due to commanded inductions or deactivations can be compared to their expected value and used to diagnose proper induction behavior, i.e.", "was the cylinder skip/fire executed as commanded and/or was the valve lift schedule executed as commanded.", "The diagnostic filter used may be built by filtering the input signal 612 using two identical cascaded first order low pass filters 602 and 604 and then subtracting this output 610 from the input signal 612 as shown in FIG.", "6.This architecture results in an output filtered signal 608 without any DC offset and reduced low frequency content.", "Diagnostic filter 600 may be referred to a complementary filter, since it separates out and isolates high frequency components from the overall signal.", "This filter has minimal phase delay, which allows detection of an induction fault during the same engine cycle as the fault occurs.", "While the filter structure shown in FIG.", "6 works well it is not the only form possible, and other types of low pass filter structures may be used.", "The ωfil input to first low pass filter 602 and second low pass filter 604 is based on the intake manifold cutoff frequency, the inverse of the manifold filling or emptying exponential time constant.", "The manifold's 3 dB cutoff frequency ωman, may be determined from the manifold dimensions and dynamic response or some other means.", "The frequency ωfil may be a multiple, K, of the manifold's 3 dB cutoff frequency ωman and K may be on the order of 10.The constant K depends on various engine parameters such as, but not limited to, manifold volume, total engine displacement, and number of cylinders.", "It also may vary as a function of engine parameters such as, but not limited to, cam angle, valve lift schedule, and engine speed.", "It also may vary with the control implementation architecture such as a discrete or continuous implementation.", "As mentioned previously, subtraction of the output 610 from the initial signal 612 results in an output filtered signal 608 with no DC and lower frequency components, concentrating diagnosis on higher frequency components induced by valve operation faults.", "The diagnostic filter 600 uses ωfil to lessen the effect of low frequency pressure variation from driver input and low frequency filling and emptying disturbances.", "This aids in the application of a threshold because the filter output produces large positive deviations at a fault.", "A positive deviation produced by a fault will exceed the applied threshold.", "FIG.", "7A shows the resultant diagnostic filter output 608 derived from MAP signal 504 shown in FIG.", "5B.", "Also included for reference in FIG.", "7A is the MAP signal 504 and fire enable signal 502.Region 720 represents a fault free region where the engine is properly executing induction commands from the engine controller.", "Once again the commanded skip event 510 fails to deactivate the intake valve and the cylinder experiences an induction event.", "When this fault occurs the diagnostic filter output 608 exceeds a threshold 710 generating an induction fault signal (not shown in FIG.", "7A).", "Note that filter output 608 has an average value near zero (reference on right side vertical axis in FIG.", "7A).", "The fault diagnostic apparatus and method described above work well for engines operating with repetitive firing patterns; however, it may not be robust under dynamic skip fire operation.", "Dynamic skip fire operation is quite different from the operation in a more conventional engine, in which each working chamber is steadily fired; for example, once every two engine revolutions for a 4 stroke engine.", "Because dynamic skip fire engine control can involve different working chambers with different firing sequences, there is a greater likelihood of complex MAP behavior especially during transient operation when the firing fraction is changing.", "Since the filtered output 608 drifts in transient engine operation and may result in false fault indications, improved fault detection can be achieved by applying additional processing to the filtered output 608.The results of this approach are shown in FIG.", "7B.", "This figure is similar to FIG.", "7A with common designators, except with the filtered output 608 has been replaced by an output signal 730 and the thresholds 710 and 740 may be different.", "In FIG.", "7B an induction fault is detected once the output signal 730 exceeds the threshold 740.Again, note that filter output 730 has an average value near zero (reference on right side vertical axis in FIG.", "7B).", "Output signal 730 may be produced using a system shown in FIG.", "8.FIG.", "8 is a schematic diagram of a system 800 that takes as inputs filtered output 608 from the diagnostic filter 600 and firing information from the engine controller 100 (shown in FIG.", "4).", "The system 800 takes the difference between the filtered output 608 and a delayed version of that signal 810 to produce an output signal 730.The amount of delay is determined by variable delay block 802, which has as an input firing information 804 from the engine controller.", "In one embodiment input firing information 804 includes the operating firing fraction.", "The time delay interval applied by time delay block 802 may be the firing fraction denominator multiplied by the period between firing opportunities.", "This effectively produces an output signal 730 that compares the filtered output 608 behavior for the current firing opportunity with its value at the last similar firing opportunity, i.e.", "the same phase in the cyclic firing pattern.", "As shown in FIG.", "7B there is less variation in the output signal 730 than filtered output 608 in the region of fault free operation 720.During transients the firing fraction may not be uniform, so the firing fraction denominator is not uniquely defined.", "In this case, the time delay chosen may be the most recent firing opportunity that has the same commanded induction conditions as the opportunity under test.", "This algorithm also has lower noise on the output signal 730 as compared to the filter output 608.It should be appreciated that the rates of sampling and filtering may be adjusted to provide robust fault detection without excessive processing requirements.", "For example, the MAP signal may be delivered at 1 msec rate, while the diagnostic filter output 608 may update at a less frequent interval, such as 90 degrees of crank angle as depicted in FIGS.", "7A and 7B.", "The sampling and processing rates may be based on time, crankshaft rotation (angle), or various combinations and permutations thereof.", "Also the threshold level for fault detection may be a variable based on engine MAP, engine speed, and other variables.", "The preceding description of an induction fault detection apparatus and method has used an example of detecting an induction failure resulting from a commanded skip event erroneously resulting in an unintended cylinder induction event.", "The same methods and apparatus may be used with the appropriate adjustment of the thresholds to detect other types of induction failures, such as a fire command resulting in a skip, a high lift command resulting in a low lift or a low lift command resulting in a high lift.", "It should also be appreciated that other filtering methods may be used to isolate the fluctuations associated with specific induction opportunities and determine whether they match the predicted fluctuations.", "Intake Manifold Pressure Sample(s) Based Diagnostics In some alternative embodiments, the intake manifold pressure based diagnostics can be based on one or more specific samples without requiring any of the filtering described in conjunction with some of the preceding embodiments.", "The basis for such sample based diagnostics will be described with reference to FIGS.", "11A-11J.", "FIGS.", "11A-11E are a series of graphs illustrating variations in manifold pressure that may occur during skip fire operation at a firing fraction of ⅓ and the generation of a fault signal based thereon.", "The graphs help to illustrate detection of a failure to deactivate an intake valve that should have been deactivated as part of a skipped firing opportunity, but instead activated due to a fault causing an induction event.", "Since the detected fault is a failure to deactivate, it can only occur on skipped firing opportunities.", "Skipped firing opportunities are highlighted in gray in FIGS.", "11B-11D.", "FIG.", "11A shows a firing sequence that is generated when a firing fraction of ⅓ is used with most evenly spaced firings.", "In this figure, “1's” represent fire commands 1102 and “0's” represent skip commands 1103.In FIGS.", "11B-11E that follow, the regions corresponding to the skips are highlighted by graying.", "FIG.", "11B is a graph that diagrammatically represents variations of the manifold pressure 1105 that might be seen during steady state operation of a four cylinder engine at a firing fraction of ⅓ at a given engine speed.", "FIG.", "11C is a graph showing manifold pressure readings sampled at a rate of one sample per firing opportunity with the sample being taken late in the corresponding intake stroke.", "FIG.", "11D is a graph diagrammatically representing the difference between the current manifold pressure reading and the manifold pressure reading for the previous induction opportunity (firing opportunity).", "FIG.", "11D also illustrates a comparison of the difference to a fault threshold.", "FIG.", "11E is a graph diagrammatically representing a fault signal that may be generated when an induction fault is detected.", "In each of the graphs, the X-axis is represented in firing opportunities.", "For a four cylinder, 4 stroke engine successive firing opportunity are separated by 180° of crankshaft rotation.", "In FIGS.", "11B and 11C the manifold pressure is represented in the Y-axis.", "In FIG.", "11A, the Y-axis represents the decision whether to skip or fire a particular firing opportunity.", "In FIG.", "11D, the Y-axis represents the difference between the current sampled manifold pressure and the previous sampled manifold pressure.", "In FIG.", "11E, the Y-axis represents the detection of an induction fault.", "As can best be seen in FIG.", "11B, once a particular intake event is completed (marked at points 1111), the intake manifold pressure begins to rise and continues to rise until the intake event associated with the next fired working cycle begins (marked as points 1113).", "Thus, when operating at the firing fraction of ⅓ which has a repeating pattern of Fire-Skip-Skip, the intake manifold pressure will rise during the two skipped intake events.", "When an induction event occurs, the manifold pressure drops noticeably until the induction is completed (points 1111) at which point the cycle repeats.", "If the intake valve fails to deactivate when it was supposed to (thereby causing an induction event occurs when it was not supposed to), the manifold pressure during the corresponding expected skipped “intake” interval will be lower than expected because air is withdrawn from the manifold when it was not expected.", "The intake manifold pressure that might be seen after such an intake fault is diagrammatically represented by the dashed line in FIG.", "11B marked 1120.As seen therein, the intake manifold pressure will often decrease when an intake valve fails to deactivate as intended—resulting in a noticeable decrease in the manifold pressure, relative to the expected pressure (which was expected to increase).", "The greatest difference between the measured manifold pressure and the expected manifold pressure is typically around the time that the intake valve for the associated cylinder is expected to close which is in the vicinity of the point marked as 1124.In some embodiments, induction faults are identified by comparing a manifold pressure reading associated with an expected induction event with a manifold pressure reading associated with the previous induction opportunity.", "Preferably, the pressure readings are taken at substantially the same phases in their respective working cycles.", "FIG.", "11C diagrammatically illustrates intake manifold pressure samples 1130 that might be taken in an engine operating at a ⅓ firing fraction as illustrated in FIG.", "11B.", "One sample is taken corresponding to each induction opportunity.", "The intake manifold pressure that might be seen after an induction fault (failure to deactivate) is represented by the dashed line marked 1130(a).", "It can be seen that significant differences can be seen between the sampled pressure and the expected pressure when an induction unexpectedly occurs.", "FIG.", "11D is a graph diagrammatically representing the difference 1135 between the current manifold pressure reading and the manifold pressure reading that was obtained for the immediately preceding induction opportunity.", "As will be described in more detail below with respect to FIG.", "12, this difference is compared to a fault threshold 1137 and a fault signal 1138, shown in FIG.", "11E, is generated thereby identifying a fault when the threshold is “exceeded” (past).", "It should be noted that when we are trying to identify a deactivation fault, in the illustrated context, the threshold is “exceeded” or “past” when the difference is less than, or more negative than, the threshold.", "Obviously the positive or negative direction of what constitutes “exceeding” the threshold will depend on whether the previous manifold pressure is subtracted from the current manifold pressure to determine the differential, or the current sample is subtracted from the previous sample.", "Another point worth noting in FIG.", "11D is that the pressure differential detected in association with a skipped induction opportunity tends to fluctuate based on whether the previous induction opportunity was a skip or a fire (induction event).", "In practice, with all other parameters being the same, a skipped induction event that follows a fire may be expected to have a bigger pressure differential than a skipped induction event that follows another skipped induction event.", "When there are a series of skipped induction events, the pressure differential will tend to decrease with each passing skipped induction event.", "FIG.", "11E illustrates a fault signal 1138 that may be generated when a fault is detected.", "FIGS.", "11F-11J are a series of graphs illustrating variations in manifold pressure that may occur during skip fire operation at a firing fraction of ⅘ and the generation of a fault signal based thereon.", "These graphs generally correspond to the graphs of FIGS.", "11A-11E, except that they show similar events in the context of operating the engine at a firing fraction of ⅘.", "FIG.", "11G shows representative variations in the intake manifold pressure 1155 while operating at a firing fraction of ⅘.", "The effect of a failure to deactivate an intake valve in a working cycle that follows a single skip is illustrated by the dashed line marked 1170.As can be seen, the greatest differences between the measured manifold pressure and the expected manifold pressure are again around the times that the intake valves for the associated cylinders are expected to close—which is marked by point 1174.FIG.", "11H shows representative pressure samples 1180 for each firing opportunity with dashed lines 1180(a) illustrating the results that might be seen in association with the deactivation failure illustrated in FIG.", "11G.", "FIG.", "11I shows the pressure differentials 1185 observed at each firing opportunity with the dashed line labeled 1185(a) illustrating differentials that might be observed in connection with the deactivation failure illustrated in FIG.", "11G.", "FIG.", "11J shows a detected deactivation fault 1188.The type of fault described above with respect to FIGS.", "11A-11J is a failure to deactivate an intake valve.", "That is, the valve opens when it was expected to remain closed.", "However, the same graphs can be used to illustrate the differences that might occur when a failure to activate (reactivate) an intake valve occurs.", "Such faults can occur on firing opportunities where a fire is intended.", "If the intent was to introduce an air charge into the corresponding working chamber at the points at which lines the dashed lines 1120 and 1170 separate from the corresponding solid lines, then the expected manifold pressure would follow the dashed line.", "Conversely, if a fault occurred at that point and the intake valve failed to open in the intended manner, the manifold pressure would follow the solid line.", "Thus, it should be apparent that the same approach can be used to identify failure to reactivate faults—although the appropriate firing opportunities and default threshold would be different.", "FIGS.", "11A-11J illustrate the pressure variations that would occur in the event that the deactivation of the intake valve completely fails (i.e., the valve fully opens when it was intended to be held closed).", "There can be other types of induction faults as well.", "For example, there may be timing fault errors in which a valve opens later or earlier than expected and/or valve lift errors in which the valve opens with a different valve lift than expected, etc.", "Each of these different types of faults will have an impact on the manifold pressure and it will often be possible to identify such faults—or at least the occurrence of a fault—using the same approach.", "Referring next to FIG.", "12, a method of detecting induction faults in accordance with this embodiment will be described.", "The described process may be performed by software or firmware executed by an induction fault detection unit or other diagnostic unit.", "The induction fault detection unit may be part of a diagnostic module, the ECU or any other control module for the engine.", "In the illustrated embodiment, the current manifold pressure is sampled at a designated phase of the current firing or induction opportunity as represented by block 1203.The specific timing at which the sample readings used in the induction fault analysis are made may vary widely based on a variety of factors including factors such as the timing of available manifold pressure samples, cam timing and/or valve lift, the number of operating cylinders, engine speed, etc.", "In a 4-stroke piston engine, the designated phase will typically be somewhere in the range of 120° to 180° past the top dead center that corresponds to the beginning of the intake stroke (as for example 150° past top dead center) as will be described in more detail below, although that is not a strict requirement.", "The current manifold pressure is compared to the manifold pressure that was detected in the preceding induction opportunity as represented by block 1206 to determine the pressure differential.", "In parallel, the induction fault detection unit determines the induction fault threshold for current operating conditions as represented by block 1209.Typically this is accomplished using one or more look-up table(s) although in other embodiments, the appropriate fault thresholds may be identified using other suitable approaches including algorithmically, using other data structures, using fixed threshold values, etc.", "One of the reasons that look-up tables work well is that the intake manifold dynamics, and therefore the appropriate pressure differential threshold for identifying induction faults, can vary significantly based on the engine's current operating conditions.", "There are a number of factors that influence intake manifold dynamics including the manifold's size and shape, atmospheric pressure, cam timing, recent induction history (e.g., skip/introduce in a skip fire controlled engine, or the charge level of recent air charges in multi-charge level engine operation), engine speed, variations in throttle position, the impact of turbo or super chargers in engines so equipped, etc.", "For example, with all other factors being the same, when the manifold pressure is higher, the pressure differential will be higher.", "When the engine speed is higher, the pressure differential will be lower since the cylinder has less time to draw air from the manifold when the valve is open.", "The number of skipped induction opportunities that immediately precede a particular induction opportunity will also affect dynamics because the amount of air introduced into the intake manifold during a skipped working cycle will typically drop after each skipped induction opportunity as the pressure differential across the throttle drops due to filing of the intake manifold.", "When an induction opportunity is intended to be skipped, the measured manifold pressure should typically be higher than the pressure measured in the previous induction opportunity.", "In contrast, the measured manifold should typically be no higher (often significantly lower) than the previous measurement if the intake valve opened and an induction event occurred.", "However, since the throttle position, valve timing and/or other engine dynamics may be changing and the pressure samples may not be taken at the very end of an intake valve opening period, the pressure can foreseeable decrease some amount between sequential readings even when a skip occurs.", "In contrast, if the valve opened unexpectedly after a skip, the manifold pressure reading should have decreased noticeably.", "Due to the variations in manifold dynamics, it is often appropriate to utilize different induction fault thresholds for different operating conditions.", "To facilitate this, lookup tables may be used to select an appropriate pressure differential threshold for the current operating conditions, and different tables may be used based on whether the current induction opportunity is expected to intake air or skip induction.", "Generally different tables would be used to identify failure to deactivate inductions faults (failure to skip an induction event as intended) than are used to identify failure to activate induction faults (failure to induct air as intended during an induction opportunity).", "The lookup tables used to identify the fault thresholds may be one-dimensional or multi-dimensional and a variety of different indices may be used for the lookup table.", "In some circumstances, multiple lookup tables may be used in conjunction with one another to determine the appropriate fault threshold.", "By way of example, in some embodiments, a first lookup index may be the intake manifold pressure ratio—which is the ratio of the intake manifold pressure to barometric pressure.", "A second index may be the number of skipped induction events that immediately preceded the current induction.", "In some embodiments, an additional or alternative index may be engine speed.", "In various other embodiments the indices to the look-up table may additionally or alternatively include one or more of: (i) a skip frequency indicative of a number of induction skips that are expected to occur in a designated period of time; (ii) the current intake manifold pressure; (iii) a firing fraction or effective firing fraction indicative of the fraction or effective fraction of the firing opportunities that are actually fired; (iv) throttle position; (v) the boost pressure (in boosted engines); (vi) cam phase; (vii) the intake valve lift profile; (viii) the skip/fire decision for the next firing opportunity; or (ix) other suitable parameters.", "One specific approach to determining a failure to deactivate fault threshold will be illustrated with reference to FIGS.", "13A and 13B.", "This approach utilizes two look-up table structures cooperatively to determine an appropriate fault threshold.", "The look-up table 1301 of FIG.", "13A utilizes intake manifold pressure ratio and engine speed as its indices and each entry 1307 in the lookup table 1301 includes a base fault threshold value (indicator) 1309.The look-up table 1321 of FIG.", "13B utilizes firing fraction and the number of immediately preceding skipped working cycles as its indices and each entry 1327 in the lookup table 1321 includes a fault threshold adjustment value (indicator) 1329.To determine the fault threshold for a particular induction opportunity, both the base fault threshold value 1309 and the fault threshold adjustment value 1329 are identified (looked up) based on the current engine operating conditions.", "The two values are then added together and their sum is used as the fault threshold (composite fault threshold).", "In these particular tables, the thresholds 1309 and 1329 are provided in kilopascals (kPa)—although it should be appreciated that the values may be provided in any appropriate units.", "To illustrate the use of tables 1301 and 1321, consider an example in which the engine is operating at a firing fraction of ⅓, an engine speed of 2000 RPM, a manifold pressure ratio of 0.90 and the current firing opportunity is an intended skip (which corresponds to an intention to skip the current induction opportunity.)", "that follows a fire.", "Using the table of FIG.", "13A, in this example, the base fault threshold valve would be −0.8 kPa (based on the MAP pressure ratio of 0.90 and the engine speed of 2000 RPM) as represented by table entry 1313.Using the table of FIG.", "13B, the fault threshold adjustment value would be −0.2 kPa (based on the firing fraction of ⅓ and the preceding skip count of 1) as represented by table entry 1323.The induction fault threshold would then be −1.0 kPa (−0.8+−0.2).", "Although some particular lookup tables structures have been described, it should be appreciated that the specific structure(s) of the lookup table(s) (or other data structures) used to identify the appropriate induction fault threshold may vary widely in accordance with the preferences of any particular system.", "In some embodiments, altitude adjustments tables may be used to compensate for differences in barometric pressure.", "Altitude adjustment tables are particularly useful in implementations that don't utilize the MAP Pressure ratio, or otherwise account for variations in ambient barometric pressure.", "Returning to FIG.", "12, after both the pressure differential and the appropriate induction fault threshold have been obtained (1206, 1209), the pressure differential is compared to the induction fault threshold as represented by block 1212.If the pressure differential is beyond the threshold, a fault is identified for the current induction opportunity as represented by block 1215.Using the example from above, the pressure differential is the current pressure reading minus the pressure reading for the previous induction opportunity.", "If the current induction event was intended to be a skip and the pressure differential is a drop of more than 1.1 kPa, then it can be surmised that an induction event occurred when it was not intended, resulting in a failure to deactivate induction fault.", "It should be appreciated that the positive or negative sense of the pressure differential will vary based on whether the current pressure reading is subtracted from the previous pressure reading or vice versa.", "Similarly, what direction constitutes “exceeding” a threshold to identify a fault will vary based on how the tables are set up.", "Thus it should be appreciated that in the context of this disclosure “exceeding” or “going beyond” a threshold can refer to a difference that is mathematically more than, or less than the threshold based upon how the tables are constructed and how the pressure differential between readings is determined.", "The system may be configured to react to a detected induction fault in any way deemed appropriate by the controller designers.", "By way of example, in some embodiments, the fault is logged in a diagnostics induction fault log.", "If repeated faults are observed for a particular cylinder, a check engine light or similar warning can be activated to notify the driver to initiate maintenance.", "If repeated faults are associated with the same cylinder, that cylinder can be avoided until required maintenance is performed, etc.", "If the nature of the fault makes skip fire or other dynamic cylinder output level modulation operation of the engine untenable, such operating mode(s) can be temporarily disabled until the underlying problem that caused the fault(s) is resolved.", "If no fault is detected in block 1212 or after the fault has been indicated in step 1215, the logic indexes to the next induction opportunity (block 1218) and the entire process is repeated for the next induction opportunity.", "This process may be repeated for each induction opportunity for as long as the fault monitoring remains active.", "In some embodiments, the system may be configured to only detect failures to deactivate an intake valve to thereby skip an induction event (deactivation failures) such that only failed skips are detected.", "In other embodiments, the system may be configured to detect only failures to activate an intake valve to thereby cause an induction event (reactivation failures).", "In other embodiments, both deactivation and reactivation failures may be detected.", "In still other embodiments, the described approach may be utilized to identify situations in which the valves were activated at the wrong level or at the wrong timing.", "This latter approach is particularly relevant during multi-charge level or multi-level skip fire operation of an engine where different valve actuation levels are expected.", "It is noted that when a “low” firing is expected in a stoichiometry based engine cycle, the cylinder is typically expected to induct a noticeably lower amount of air than when a “high” firing is expected.", "The lower air intake leads to a correspondingly higher manifold pressure and such differences can readily be detected using the described approach by using appropriate fault thresholds.", "In some embodiments, separate tables can be used to identify deactivation (or reactivation) failures and improper activation level failures to allow the nature of a detected failure to be more specifically determined.", "As suggested above, when intake manifold pressure sampling is done, it is generally desirable to sample the manifold pressure at a point that is relatively late in the induction event.", "Therefore some care is preferably taken in choosing the timing of the sampling.", "Many engine controllers are configured to sample sensors at designated intervals that are based on crankshaft rotation.", "For example, some mid-level resolution controllers may be arranged to sample selected sensors (such as an intake manifold pressure sensor) every 30° of crankshaft revolution.", "Often one of the samples corresponds to the top dead center position of the piston as the intake stroke is about to begin.", "In such an embodiment, the sample that occurs at 150° into the working cycle works often works well for use in determining induction faults—although it should be appreciated that a wide variety of other sampling approaches can be used in other embodiments.", "In some implementations it can be helpful to use the average of more than one sample in the determination of the “current” manifold pressure to be used by the induction fault detection algorithm.", "For example, the average or weighted average of 2 or 3 relevant samples may be used as the current manifold pressure reading.", "For example, in the context of the aforementioned mid-resolution sensor sampling approach, pressure samples may be available for time corresponding to 120°, 150°, and 180° of crankshaft rotation past top dead center.", "In various embodiments two or three of these samples could be averaged together to provide the current manifold pressure reading using either straight averaging or weighted averaging.", "For example, in a particular implementation two samples (e.g., 150° and 180°) could be averaged or a weighted average could be attained that applies a first (e.g.", "70%) weighting to the first (e.g.", "150°) sample and a second (e.g.", "30%) weighting to the second (e.g.", "180°) sample.", "In implementations where the manifold pressure samples are available at different rates—as for example at different crankshaft rotation locations or at time based periodic intervals that are independent of crankshaft rotation, the selection of the appropriate sample or samples to use as the measured manifold pressure can be selected appropriately.", "In engines that utilize late intake valve closure (LIVC) to facilitate multi-level operation (such as Miller cycle operation), it may be desirable to utilize samples later in the working cycle (e.g.", "180° or more after top dead center) to better account for the impacts of pushing air out of the cylinder during the first part of the “compression” stroke.", "The graphs of FIGS.", "11A-11J show applications of the invention in the context of a conventional 4-stroke engine having four cylinders.", "A characteristic of most 4 cylinder 4-stroke engines is that the intake stroke associated with the next firing opportunity typically will not have started when the intake manifold pressure sample is taken for any particular firing opportunity.", "This is because the intake strokes for sequential firing opportunities typically begin 180° apart and the intake stroke is 180° long.", "When the pressure sample for a particular firing opportunity is taken before the intake valve for the next firing opportunity is potentially opened, then the next firing decision does not interfere in any way with the pressure reading regardless of whether the subsequent firing decision is a skip or fire.", "In contrast, in engines having six, eight, or more cylinders, intake valve opening overlaps between sequentially fired cylinders are often expected.", "For example, in eight cylinder engines, sequential firing opportunities typically begin 90° apart.", "Therefore, in circumstances in which the “next” cylinder is intended to be fired and the pressure reading is made 150° into the intake stroke, it might be expected that the intake valve for the “next” cylinder will have opened before the intake manifold reading is made—which will affect the detected manifold pressure.", "These effects can be accounted for in a variety of different ways including via selection of the appropriate fault threshold and/or selecting the timing/phase of the pressure readings (or the effective phase in circumstances in which the pressure reading averages or weighted averages more than one pressure sample).", "In some embodiments, the effects of the next firing decision might be integrated into a lookup table.", "For example, the next firing decision can be an additional index for the fault threshold lookup table such that the fault threshold varies based on whether the next firing opportunity is a skip or a fire.", "In engines with multiple firing levels the firing level may be used as an additional index.", "It is noted that this information is readily available to the diagnostics module because the next firing decision has to be made before the intake stroke for that cylinder begins so that the intake valve can be controlled appropriately.", "In 6-cylinder engines, the overlap between potential valve openings tends to be less, so it is less of a problem, but the impacts of the overlap can be accounted for in the same ways.", "It should be appreciated that there can also be valve opening overlap during operation of a four cylinder engine.", "For example, in many implementations, the intake valve for a particular working cycle may open near the end of the exhaust stroke in that cylinder's preceding working cycle.", "In another example, a valve may be operated using late intake valve closing (LIVC) control in some operational circumstances.", "The impacts of these types of overlaps can typically be accounted for by selecting the appropriate manifold pressure sampling timing and/or setting the fault threshold at a value that is unaffected by such types of overlapping.", "In other embodiments, the magnitude of the fault threshold can be based in part on the firing decisions for the next cylinder as discussed above.", "Crankshaft Angular Acceleration Based Diagnostics In some embodiments an algorithm using information on the crankshaft angular acceleration can be used to determine induction faults.", "FIG.", "9 shows the torque profile of a cylinder over an engine cycle associated with different types of commanded intake valve action.", "A fire command with a high lift valve schedule generates a large torque pulse after top dead center (TDC), curve 1010.A fire command with a low lift valve schedule generates a smaller torque pulse after top dead center (TDC), curve 1012.Both curves 1010 and 1012 also show a negative torque pulse prior to TDC.", "In contrast a commanded skip, having no induction since the intake valve remains closed, results in little torque either generated or absorbed, curve 1014.These torque signature differences may be used to diagnose induction faults.", "The torque signature of all engine cylinders and other engine loads can be estimated to determine a total net torque acting on the crankshaft.", "In skip fire operation the torque signature of each cylinder can vary on a cycle by cycle basis and this must be considered in the calculation of total net torque.", "Since the crank angular acceleration is proportional to torque, the net crankshaft angular acceleration can be calculated.", "The calculated angular acceleration may be defined as a reference angular acceleration.", "The reference angular acceleration represents the anticipated crank angular acceleration in the absence of any faults.", "Actual crankshaft angular acceleration can be determined using input from a crank rotation sensor that measures the time period between passages of successive crank mounted indices past a fixed point.", "The measured crankshaft acceleration signal can be compared with the reference acceleration.", "If the measured acceleration signal deviates from the reference acceleration by more than a prescribed threshold a fault signal is generated.", "It is advantageous to compare the measured and reference crank acceleration in a time window 1013 slightly before and somewhat after TDC between the compression and power stroke of the cylinder under test.", "As shown in FIG.", "9 the difference in torque between the different induction states (high lift, low lift, no lift) is greatest in this area, so detecting the differences is easiest during this time window.", "The comparison may be made over the entire time window 1013 or any portion or multiple portions thereof.", "In determining the reference acceleration it is essential to consider operation of other engine cylinders in addition to the cylinder under test.", "Generally the engine cylinders adjacent to the cylinder under test in the engine firing order have the most influence on the torque during the induction fault test window 1013 and are most important to consider when determining the reference acceleration.", "Of particular importance is whether these cylinders were skips or fires because, as shown in FIG.", "9, the largest torques are generated during the compression and power stroke and these strokes of the adjacent cylinders can partially overlap with the fault detection window of the cylinder under test.", "The adjacent cylinder firing pattern can take four possible forms, i.e.", "skip-skip, skip-fire, fire-skip, fire-fire.", "Depending on the adjacent cylinder pattern the reference threshold may vary.", "The influence of adjacent cylinders on the expected torque from a cylinder under test is described in U.S. patent application Ser.", "Nos.", "14/207,109 and 14/880,652, which are incorporated herein by reference.", "In other embodiments, more complex cylinder pressure models that consider the effects of still other (e.g.", "non-adjacent) cylinders may be used to determine the reference crank acceleration.", "This may be a model that considers the impact of all of the cylinders or a larger subset of the cylinders beyond simply the adjacent cylinders in the firing order.", "Some such models are described in the incorporated '652 application.", "Aside from and/or in addition to crankshaft angular acceleration, the time derivative of the angular acceleration, jerk, may be used to detect induction faults.", "FIG.", "10 shows the jerk as a function of crankshaft angle.", "Curves 1020, 1022, and 1024 show the jerk associated with the high lift, low lift, and no lift induction states, respectively.", "These three jerk curves are effectively the slope of the angular acceleration curves 1010, 1012, and 1014 shown in FIG.", "9.The time window for induction fault detection 1023 using crank jerk may be smaller than the detection window using crank acceleration 1013, since the jerk peaks are narrower in time than those associated with the angular acceleration.", "In should be appreciated that while the methods described here compare a reference angular acceleration or jerk with the corresponding measured values, substantially equivalent comparison may be made using other parameters.", "For example, instead of determining a reference angular acceleration a reference torque may be determined.", "A comparison may then be made whether the measured torque (based on the crankshaft angular acceleration) is consistent with the reference value.", "Additionally, in some skip fire control schemes when a cylinder under test is scheduled to be a skip, but the intake valve fails to deactivate, air is inducted into the cylinder during the intake stroke and compressed; however, it is not fired during the combustion stroke.", "In such operation the cylinder is operating as an air spring.", "This operational mode produces a distinctive torque and jerk signature like those shown in FIGS.", "9 and 10 for other operational modes.", "An induction fault in this operational mode may be detected using the same techniques as described above.", "Other Features While detection of an induction fault has been described by measuring the MAP and crankshaft accelerations it should be appreciated that the approaches may be combined with each other.", "That is both a MAP based fault signal and crank acceleration based fault signal could be input into an AND gate.", "A fault would only be registered if both inputs indicated the presence of a fault.", "In an alternative architecture the MAP and crankshaft based diagnostics could produce a three state (yes, no, and maybe) or continuous output.", "These outputs could be combined in various ways to generate the fault signal.", "For example, one system producing a “maybe” and the other producing a “yes” may be interpreted as a fault.", "Alternatively, both systems may generate a continuous value between 0 and 1, where 0 represents definitely no fault and 1 represents definitely a fault.", "Intermediate values can be combined in various ways to determine whether a fault is present For example if the MAP based system gave a reading of 0.8 and the crank based system gave a reading of 0.6 these readings could be summed to give a value of 1.4, which might be above a detection threshold indicating a fault.", "These types of architecture combining multiple inputs may result in fewer false positive fault detections than a system based on a single measured parameter.", "It is also possible to combine the MAP and/or crank fault signal with other diagnostic signals; for example, an intake valve proximity sensor, an in-cylinder pressure sensor, an exhaust pressure sensor and/or oxygen sensor, to provide for a further reduced error level.", "The generated fault signals may be inputted into an OBD system.", "The OBD system may perform statistical analysis on the fault signals to determine whether any corrective action is required.", "For example, reoccurring faults on a particular cylinder may indicate a failure in some aspect of that cylinder's induction system requiring corrective action.", "An indicator may alert a vehicle driver that such action is required.", "The figures refer to subcomponents and functional blocks that perform various functions.", "It should be appreciated that some of these subcomponents may be combined into a larger single component, or that a feature of one subcomponent may be transferred to another subcomponent.", "The present invention contemplates a wide variety of control methods and mechanisms for performing the operations described herein, and is not limited to what is expressly shown in the figures.", "For example, in the various illustrated embodiments, the firing information provided to the induction failure detection unit 102 is typically described as coming from the firing fraction calculator 112 and/or the firing timing determination module 120.Although this architecture works well, it should be appreciated that such information can come from any suitable source.", "For example, in many implementations, the functionality of the firing fraction calculator and firing timing determination module will be accomplished by an engine control unit (ECU) or a power train controller that may not incorporate readily identifiable modules that perform the corresponding functions.", "The invention has been described primarily in the context of controlling the firing of 4-stroke piston engines suitable for use in motor vehicles.", "However, it should be appreciated that the described skip fire approaches are very well suited for use in a wide variety of internal combustion engines.", "These include engines for virtually any type of vehicle—including cars, trucks, boats, construction equipment, aircraft, motorcycles, scooters, etc.", "; and virtually any other application that involves the firing of working chambers and utilizes an internal combustion engine.", "The various described approaches work with engines that operate under a wide variety of different thermodynamic cycles—including virtually any type of two stroke piston engines, diesel engines, Otto cycle engines, Dual cycle engines, Miller cycle engines, Atkinson cycle engines, Wankel engines, axial engines and other types of rotary engines, mixed cycle engines (such as dual Otto and diesel engines), radial engines, etc.", "It is also believed that the described approaches will work well with newly developed internal combustion engines regardless of whether they operate utilizing currently known, or later developed thermodynamic cycles.", "The described embodiments can be adjusted to work with engines having equally or unequally sized working chambers.", "While the described embodiments work well with dynamic skip fire engine operation, it should be appreciated that it may be applied to other types of engine control which may be concerned about the possibility of induction faults.", "This includes virtually any skip fire application (operational modes in which individual cylinders are sometimes fired and sometime skipped during operation in a particular operational mode) including skip fire operation using fixed firing patterns or firing sequences as may occur when using rolling cylinder deactivation and/or various other skip fire techniques.", "Similar techniques may also be used in various skip fire like techniques such as multi-charge level engine operation or other cylinder output level modulation techniques.", "Similar techniques may also be used in connection with variable stroke control engine operation.", "In variable stroke engine control, the number of strokes in each working cycle are altered to effectively vary the displacement of an engine.", "In multi-charge level engine operation, the output of fired cylinders are varied dynamically in a skip/fire type pattern.", "For example, a particular cylinder may sometimes be fired at a “high” or “higher” torque output level and may sometimes be fired at a “low” or “lower” torque output level, with the “low” output levels corresponding to the “skips” and the “high” output levels corresponding to the fires in a skip fire pattern.", "In another example, a multi-level skip fire pattern may include some “skips”, some “low” firings and some “high” firings.", "A variety of multi-charge level modulation and multi-level skip fire techniques are described in Applicant's U.S. patent application Ser.", "No.", "14/919,018, which is incorporated herein by reference.", "One way to differentiate between “high” and “low” firings is to modulate the valve lift which can lead to valve lift fault based induction faults which can be detected using the described techniques.", "The invention has generally been described in terms of a skip fire control system that fires a fuel/air charge during the same cycle as the induction event that filled the cylinder with the charge.", "Also, the invention has generally been described in terms of a skip fire control system that vents the combustion gases from a cylinder firing during an exhaust stroke immediately following the power stroke where the fuel/air charge was firing.", "Neither of these valve control schemes is a requirement.", "A cylinder may induct an air charge and wait one or more cycles before firing the charge.", "Similarly, a cylinder may hold combustion gases within the cylinder for one or more engine cycles after a combustion event.", "Engines operating in this manner will have different MAP and crankshaft variation signatures, but the methods described here can be readily adapted to accommodate these different valve control schemes.", "Although only a few embodiments of the invention have been described in detail, it should be appreciated that the invention may be implemented in many other forms without departing from the spirit or scope of the invention.", "Therefore, the present embodiments should be considered illustrative and not restrictive and the invention is not to be limited to the details given herein." ] ]
Patent_15872675
[ [ "Fundus Imaging System", "A fundus imaging system includes: an image sensor array, where the image sensor array includes monochrome photodiodes and global shutter control, an illumination unit with one or more light-emitting diodes that have one or more dies, a computing system including a processor and memory, one or more lenses, one or more reflective mirrors, and a display.", "In an example method of use, a clinician positions a patient, initiates a focal adjustment, initiates a retinal imaging process, and the same or a different clinician views the image.", "In some embodiments, the imaging system is configured to analyze the image and identify detected physical attributes in the image relating to the diagnosis and treatment of diabetic retinopathy." ], [ "1.A non-mydriatic fundus imaging system, comprising: an image sensor array capable of global reset operations, the global reset operations including exposing each pixel of a plurality of rows of pixels substantially simultaneously; an illumination unit operatively coupled to the image sensor array, wherein the illumination unit includes a multi-die light emitting diode; a timing unit operatively coupled to the image sensor array and the illumination unit and configured to simultaneously expose each pixel of the plurality of rows of pixels of the image sensor array during an exposure period.", "2.The non-mydriatic fundus imaging system according to claim 1, the image sensor array including a two-dimensional monochrome complementary metal-oxide-semiconductor.", "3.The non-mydriatic fundus imaging system according to claim 1, further comprising: a processor; and memory storing instructions that, when executed by the processor, cause the non-mydriatic fundus imaging system to: capture a plurality of images in a first image capture mode; process at least a portion of the plurality of images to determine a position of a pupil of a subject; and capture an image in a second image capture mode when the position of the pupil is substantially aligned with an optical axis of the non-mydriatic fundus imaging system.", "4.The non-mydriatic fundus imaging system according to claim 3, wherein: the first image capture mode comprises a first resolution and a first illumination condition; and the second image capture mode comprises a second resolution and a second illumination condition.", "5.The non-mydriatic fundus imaging system according to claim 4, wherein: the second resolution is greater than or equal to the first resolution; and the second illumination condition is brighter than the first illumination condition.", "6.The non-mydriatic fundus imaging system according to claim 5, the second image capture mode including overdrive of the multi-die light emitting diode during the global reset operations.", "7.The non-mydriatic fundus imaging system according to claim 6, the illumination unit being configured to emit monochrome light for less than 2 milliseconds during the second image capture mode.", "8.The non-mydriatic fundus imaging system according to claim 7, the illumination unit being configured to cause the multi-die light emitting diode to, consecutively, illuminate red light only, illuminate green light only, and illuminate blue light only.", "9.The non-mydriatic fundus imaging system according to claim 7, the illumination unit being configured to cause the multi-die light emitting diode to illuminate red, green and blue simultaneously.", "10.The non-mydriatic fundus imaging system according to claim 1, the image sensor array further being capable of global transfer operations, the global transfer operations including simultaneously ceasing exposure of each pixel in the image sensor array.", "11.The non-mydriatic fundus imaging system according to claim 10, the global transfer operations further including transferring charge from each pixel in the image sensor array into opaque shielded storage.", "12.The non-mydriatic fundus imaging system according to claim 11, the image sensor array further being capable of sequential readout operations.", "13.A method for producing an image of a fundus, the method comprising: illuminating a light emitting diode, the light emitting diode being a multi-color die LED; activating a shutter of an image sensor array capable of exposing each pixel of a plurality of rows of pixels substantially simultaneously; and storing an image readout from the plurality of rows of pixels.", "14.The method according to claim 13, further comprising initiating global transfer operations, including simultaneously ceasing exposure of each pixel in the image sensor array.", "15.The method according to claim 14, the initiating global transfer operations further including transferring charge from each pixel in the image sensor array into opaque shielded storage.", "16.The method according to claim 14, further comprising initiating sequential readout operations.", "17.The method according to claim 13, wherein illuminating the light emitting diode includes emitting monochrome light for less than 2 milliseconds.", "18.The method according to claim 17, wherein illuminating the light emitting diode includes illuminating red light only, illuminating green light only, and illuminating blue light only; and further comprising capturing an image during each of illuminating red light only, illuminating green light only, and illuminating blue light only.", "19.A non-mydriatic fundus imaging system, comprising: an image sensor array, configured for: global reset operations, the global reset operations including exposing each pixel of a plurality of rows of pixels substantially simultaneously, global transfer operations, the global transfer operations including simultaneously ceasing exposure of each pixel in the image sensor array and transferring charge from each pixel in the image sensor array into opaque shielded storage; and sequential readout operations; an illumination unit operatively coupled to the image sensor array, the illumination unit including a multi-die light emitting diode; and a timing unit operatively coupled to the image sensor array and the illumination unit and configured to simultaneously expose a full frame of pixels of the image sensor array during an exposure period.", "20.The non-mydriatic fundus imaging system according to claim 19, further comprising: a processor; and memory storing instructions that, when executed by the processor, cause the non-mydriatic fundus imaging system to: capture a plurality of images in a first image capture mode; process at least a portion of the plurality of images to determine a position of a pupil of a subject; capture an image in a second image capture mode when the position of the pupil is substantially aligned with an optical axis of the non-mydriatic fundus imaging system, the first image capture mode comprises a first resolution and a first illumination condition; the second image capture mode comprises a second resolution and a second illumination condition; the second resolution is greater than or equal to the first resolution; and the second illumination condition is brighter than the first illumination condition the image sensor array including a two-dimensional monochrome complementary metal-oxide-semiconductor; the illumination unit being configured to emit monochrome light for less than 2 milliseconds during the second image capture mode." ], [ "<SOH> BACKGROUND <EOH>People with type 1 or type 2 diabetes can develop eye disease as a result of having diabetes.", "One of the most common diabetic eye diseases is diabetic retinopathy, which is damage to the blood vessels of the light-sensitive tissue at the back of the eye, known as the retina.", "Eye exams can produce images of the back of the eye and trained medical professionals use those images to diagnose and treat diabetic retinopathy.", "Many of the current methods used to produce the images of the back of the eye, known as a fundus, suffer from various deficiencies, often producing imperfect images that can complicate the diagnostic procedure.", "Traditional imaging techniques use a Bayer-patterned color filter array imaging sensor.", "Such techniques have low sensitivity and the resulting image often suffers demosaic artifacts caused by low color resolution.", "Additionally, many of the current methods require the dilation of the patient's eyes, which is uncomfortable and inconvenient." ], [ "<SOH> SUMMARY <EOH>In one aspect, a non-mydriatic fundus imaging system includes: a monochrome complementary metal-oxide semiconductor image sensor array, where the sensor array comprises a plurality of pixels and is capable of global electronic shutter operations, the global shutter being capable of substantially simultaneously initiating exposure of the plurality of pixels and of a sequential readout of the photodiodes.", "The system also includes, in one aspect, an illumination unit operatively coupled to the image sensor array, where the illumination unit includes a light-emitting diode that can be overdriven.", "In another aspect, a method for producing an image of a fundus includes: illuminating a light-emitting diode, activating a global shutter of a two-dimensional monochrome complementary metal-oxide semiconductor sensor array, where the sensor array includes a plurality of pixels that can be exposed substantially simultaneously during the global shutter activation to obtain an image of the fundus, and storing the image readout from the plurality of pixels.", "Both the system and method can be used to screen for, monitor, and diagnose eye-related diseases such as diabetic retinopathy." ], [ "BACKGROUND People with type 1 or type 2 diabetes can develop eye disease as a result of having diabetes.", "One of the most common diabetic eye diseases is diabetic retinopathy, which is damage to the blood vessels of the light-sensitive tissue at the back of the eye, known as the retina.", "Eye exams can produce images of the back of the eye and trained medical professionals use those images to diagnose and treat diabetic retinopathy.", "Many of the current methods used to produce the images of the back of the eye, known as a fundus, suffer from various deficiencies, often producing imperfect images that can complicate the diagnostic procedure.", "Traditional imaging techniques use a Bayer-patterned color filter array imaging sensor.", "Such techniques have low sensitivity and the resulting image often suffers demosaic artifacts caused by low color resolution.", "Additionally, many of the current methods require the dilation of the patient's eyes, which is uncomfortable and inconvenient.", "SUMMARY In one aspect, a non-mydriatic fundus imaging system includes: a monochrome complementary metal-oxide semiconductor image sensor array, where the sensor array comprises a plurality of pixels and is capable of global electronic shutter operations, the global shutter being capable of substantially simultaneously initiating exposure of the plurality of pixels and of a sequential readout of the photodiodes.", "The system also includes, in one aspect, an illumination unit operatively coupled to the image sensor array, where the illumination unit includes a light-emitting diode that can be overdriven.", "In another aspect, a method for producing an image of a fundus includes: illuminating a light-emitting diode, activating a global shutter of a two-dimensional monochrome complementary metal-oxide semiconductor sensor array, where the sensor array includes a plurality of pixels that can be exposed substantially simultaneously during the global shutter activation to obtain an image of the fundus, and storing the image readout from the plurality of pixels.", "Both the system and method can be used to screen for, monitor, and diagnose eye-related diseases such as diabetic retinopathy.", "DESCRIPTION OF THE FIGURES FIG.", "1 illustrates one embodiment of an imaging system including a patient, a fundus imaging system, a network, a display, and a clinician.", "FIG.", "2 illustrates a schematic diagram of an example fundus imaging system.", "FIG.", "3 illustrates a flowchart of an example use by a clinician of the example fundus imaging system.", "FIG.", "4 illustrates a flowchart of an example method of operation of the example fundus imaging system.", "FIG.", "5 illustrates an example method of initiating a fundus imaging using passive eye tracking.", "DETAILED DESCRIPTION FIG.", "1 is a schematic block diagram illustrating an example system 100 for recording and viewing an image of a patient's fundus.", "In this example, the system 100 includes a patient P, a fundus imaging system 102, a camera 104 in communication 105 with an image processor 106, a display 108 used by clinician C with the image processor 106, and a network 110.In the example system, the fundus imaging system 102 and the display 108 are in communication either directly via communication path 107 or via the network 110 using wired and/or wireless communication schemes.", "The fundus imaging system 102 functions to create a digital image of a patient's P eye fundus.", "As used herein, “fundus” refers to the eye fundus and includes the retina, optic nerve, macula, vitreous, choroid and posterior pole.", "The patient P, in some embodiments, is being screened for an eye disease, such as diabetic retinopathy.", "In some embodiments, the system 102 can also be used to diagnose or monitor the progression of a disease such as diabetic retinopathy.", "In some embodiments, the imaging system 102 includes a handheld housing that supports the system's components.", "The housing supports one or two apertures for imaging one or two eyes at a time.", "In some embodiments, the housing supports positional guides for the patient P, such as an adjustable chin rest.", "The positional guide or guides help to align the patient's P eye or eyes with the one or two apertures.", "In some embodiments, the housing supports means for raising and lowering the one or more apertures to align them with the patient's P eye or eyes.", "Once the patient's P eyes are aligned, the clinician C then initiates one or more image captures by the fundus imaging system 102.Most known techniques for fundus imaging require mydriasis, or the dilation of the patient's pupil, which can be painful and/or inconvenient to the patient P. Example system 100 does not require a mydriatic drug to be administered to the patient P before imaging, although the system 100 can image the fundus if a mydriatic drug has been administered.", "In some embodiments, the system 100 is used to assist the clinician C in screening for, monitoring, or diagnosing various eye diseases.", "In some embodiments, the clinician C that operates the fundus imaging system 102 is different from the clinician C evaluating the resulting image.", "In the example embodiment 100, the fundus imaging system 102 includes a camera 104 in communication 105 with an image processor 106.In this embodiment, the camera 104 is a digital camera including a lens, an aperture, processor and a sensor array.", "The camera 104 has a sensor array equipped with a global shutter.", "In some embodiments, the camera 104 is configured to record an image the fundus of one eye at a time.", "In other embodiments, the camera 104 is configured to record an image of both eyes substantially simultaneously.", "In those embodiments, the fundus imaging system 102 can include two separate cameras, one for each eye.", "In example system 100, the image processor 106 is operatively coupled to the camera 104 and configured to communicate with the network 110 and/or display 108.In some embodiments, the image processor 106 regulates the operation of the camera 104.An example image processor is shown in more detail in FIG.", "2, which is described further below.", "In some embodiments, the fundus imaging system 102 is also connected to a printer, not shown in FIG.", "1.The printer can be used to produce a physical copy of the one or more fundus images produced by the fundus imaging system 102.In example system 100, the display 108 is in communication with the fundus imaging system 102 directly 107 or via the network 110.The display 108 functions to reproduce the image produced by the fundus imaging system 102 in a size and format readable by the clinician C. In some embodiments, the housing supports the display 108, which is embedded in the housing.", "In other embodiments, the display 108 is a separate component of example system 100, and may have its own housing, such as, for example, a monitor or a display on a mobile phone or tablet computer.", "In another embodiment, the display 108 is optional and the fundus imaging system 102 is connected to a cloud storage through network 110.In that embodiment, the fundus imaging system 102 transmits the one or more fundus images to the cloud storage and the images can be viewed by accessing the cloud storage.", "A more detailed discussion of an example fundus imaging system is provided with respect to FIG.", "2, below.", "In one embodiment, the fundus imaging system is connected to the network 110 (connection 101).", "The network 110 is, in turn, connected to the display 108 (connection 103).", "The connections 101 and 103 may include any type of wireless network, a wired network, or any communication network known in the art.", "For example, wireless connections can include cellular network connections and connections made using protocols such as 802.11a, b, and/or g. In other examples, a wireless connection can be accomplished directly between the fundus imaging system 102 and the display 108 using one or more wired or wireless protocols, such as Bluetooth, Wi-Fi Direct, radio-frequency identification (RFID), or Zigbee.", "Other configurations are possible.", "FIG.", "2 is a block diagram of the components in an example fundus imaging system 202.The example fundus imaging system 202 includes an image sensor array 204 that comprises monochrome photodiodes 206, shutter control 208, and opaque shielded storage 210; illumination unit 216 including light-emitting diode 218 and timing unit 220; computing system 222 including processor 224 and memory 226; lens 228, an optional aperture 232, networking unit 234, and display 236.The image sensor array 204 in the example system 202 is a complementary metal-oxide semiconductor sensor array.", "The example sensor array 204 includes monochrome photodiodes 206, shutter control 208, and opaque shielded storage 210.The example sensor array 204 functions to receive and process light reflected by the patient's fundus.", "The image sensor array 204 has a plurality of rows of pixels and a plurality of columns of pixels.", "In some embodiments, the image sensor array has about 1280 by 1024 pixels, about 640 by 480 pixels, or about 1500 by 1152 pixels.", "In some embodiments, the pixel size in the image sensor array 204 is from about four micrometers by about four micrometers; from about two micrometers by about two micrometers; from about six micrometers by about six micrometers; or from about one micrometer by about one micrometer.", "The example monochrome photodiodes 206 have a light-receiving surface and have substantially uniform length and width.", "During exposure, the monochrome photodiodes 206 convert the incident light to a charge.", "Shutter control 208 in example system 202 initiates the exposure of the photodiodes 206 and the end of the exposure of the photodiodes 206.In some embodiments, after the exposure period of the photodiodes 206 ends, the charge is transferred to opaque shielded storage 210.Shutter control 208 also controls the reset of the photodiodes 206 and the read-out of the stored charges to be processed by computing system 222.Shutter control 208 is configured to operate the image sensor array 204 as a global shutter.", "That is, substantially all of the photodiodes are exposed simultaneously and for substantially identical lengths of time.", "The global exposure effectively integrates charge substantially evenly across the image sensor array 204 during the exposure time.", "In another embodiment, a monochrome CMOS sensor with global reset mode can also be used without opaque shielded storage.", "As discussed above with reference to FIG.", "1, in some embodiments the clinician initiates the exposure of the photodiodes 206 by global reset of all the pixels.", "However, the shutter control 208 is configured to end the exposure period by global transferring all the pixels to their correspondent opaque shielded storages.", "For example, in some embodiments, shutter control 208 ends the exposure period using a predetermined time period that starts when the clinician initiates an image capture sequence.", "In some embodiments, an auto exposure control algorithm will determine the exposure period dynamically according to the illumination conditions and/or image contrast.", "A Bayer filter, not used in example system 202, essentially blocks out two-thirds of the light incident on the image sensor array.", "In contrast, the monochrome photodiodes 206 used in the example system 202 do not filter out light, which in turn improves the image quality.", "Also, because monochrome arrays do not filter light, the example fundus imaging system 202 advantageously requires roughly one-third of the light required by a fundus imaging system that employs a Bayer filter array.", "Additionally, in contrast to a system using a Bayer color filter array, the example fundus imaging system 202 can improve diabetic retinopathy screening sensitivity by reducing the number of false negatives.", "That is, the example fundus imaging system 202 can detect much lower contrast, and thereby detect more abnormal features, that the Bayer array cannot because the Bayer array limits the amount of imaged contrast.", "Additionally, the example fundus imaging system 202 can also reduce diabetic retinopathy false positives because the system 202 can produce higher uniform image quality without the Bayer array demosaic artifacts.", "The illumination unit 216 in example fundus imaging system 202 provides light to illuminate the fundus and coordinate the timing with the exposure of the image sensor array.", "The example illumination unit includes light-emitting diode 218 and timing unit 220.Example light-emitting diode 218 is in operative communication with the computing system 222 and the timing unit 220.Example light-emitting diode 218, in some embodiments, is a three-color light-emitting diode (LED), where the three colors are red, green, and blue.", "For example, the light-emitting diode 218 can be a three-channel RGB LED, where each die is capable of independent and tandem operation.", "In some embodiments, more than one LED 218 is used in the illumination unit 216.The LEDs have a maximum standard current draw rating of, for example, 20 mA, but the LED can be overdriven to draw more current, for example 30 mA (at 150% of maximum standard current), 200% of maximum current, 300% of maximum current, and 500% of maximum current in a low duty cycle usage.", "Other maximum standard current draws are possible.", "In some embodiments, the one or more LEDs 218 are overdriven during the illumination period, which is controlled by timing unit 220 in example system 202.In some embodiments, the combination of overdriving the LEDs with the global shutter operation results in a shorter exposure period.", "The shorter exposure period, in some embodiments, results in a sharper image.", "Additionally, in some embodiments the shorter illumination period results in less contraction of the pupil, thereby reducing the need for pupil dilation.", "In order to maintain the patient's P pupil size as large as possible without dilation, dim light must be used.", "In the imaging systems known in the art, this dim light requirement results in poorer image quality.", "For example, the image quality when a 16 ms LED illumination period is used is much better than when a 2 ms LED illumination period is used in the prior art systems.", "In some embodiments, the LED illumination period used in example system 202 are 2 ms, 3 ms, or 5 ms.", "The example fundus imaging system 202 advantageously uses a dimmer LED light and produces a higher quality image than those systems known in the art.", "Each die in the LED 218 is capable of independent and tandem operation.", "For example, in one embodiment, three consecutive frames are captured by the image sensor array 204.The first exposure occurs when the red die is illuminated, then the second exposure occurs when the green die is illuminated, and then third exposure occurs when the blue die is illuminated.", "The order of die illumination is different in other embodiments.", "An alternative embodiment captures three consecutive frames for the following color illuminations: red (red die on only), yellow (red and green dies on substantially simultaneously), and white (reed, green, and blue dies on substantially simultaneously).", "Again, the order of illumination color is different in other embodiments.", "In one diabetic retinopathy embodiment, the white illumination (all dies on) produces an all features detection, a red image (only red die on) assists the clinician in retinal microaneurysms and hemorrhages confirmation, and a yellow image (red and green dies on) assists the clinician in exudates confirmation.", "In some embodiments, timing unit 220 activates the illumination timing of, and light emitted from, light-emitting diode 218.Timing unit 220 is, in some embodiments, a separate component including a processor and memory that is operatively coupled to the computing system 222 and image sensor array 204.In other embodiments, timing unit 220 is a computer program stored on the memory 226 and configured to be run by the processor 224.Timing unit 220 can be configured to illuminate the light-emitting diode 218 at a time just before the image sensor array 204 initiates a global shutter exposure and to cease illumination shortly after the global shutter exposure ends.", "In other embodiments, the timing unit 220 can be configured to illuminate the light-emitting diode 218 after the global shutter exposure begins and to cease illumination before the global shutter exposure ends.", "In another embodiment, the timing unit 220 can be configured to illuminate the light-emitting diode 218 with an overlap period of time with the global shutter exposure period of time.", "In some embodiments the timing unit is configured to cause the light-emitting diode 218 to pulse or produce a strobe-like light during the illumination period.", "In the example fundus imaging system 202, the computing system 222 includes a processor 224 communicatively connected to a memory 226 via a data bus.", "The processor 224 can be any of a variety of types of programmable circuits capable of executing computer-readable instructions to perform various tasks, such as mathematical and communication tasks.", "The memory 226 can include any of a variety of memory devices, such as using various types of computer-readable or computer storage media.", "A computer storage medium or computer-readable medium may be any medium that can contain or store the program for use by or in connection with the instruction execution system, apparatus, or device.", "In the context of the present disclosure, a computer storage medium includes at least some tangible component, i.e., is not entirely consisting of transient or transitory signals The example system 202 also includes a lens 228 supported by the housing.", "Some embodiments have more than one lens supported by the housing.", "For example, one lens is used to focus the light incident on the image sensor array 204 and another lens to focuses the light from the illumination unit 216.Some embodiments use more than one lens to focus the incident light.", "In some embodiments, the lens has mechanical power and control connections coupled to the computing system 222.The computing system 222 may be configured to control the position of the lens or lenses to optimize lens positioning for auto focusing for the image sensor array 204 and illumination unit 216.In some embodiments, lens focusing is required in spite of a standard positioning guide for the patient because of unique facial geometries.", "The example fundus imaging system 202 has, optionally, one or more apertures 232 supported by the housing.", "In some embodiments, the aperture 232 is an annular piece that supports a lens 228.The patient's eye is aligned substantially with the aperture 232 before the fundus is imaged.", "In some embodiments, the aperture is a mechanically operated cover that can be opened and closed based upon signals from the computing system 222.In some embodiments, the example fundus imaging system 202 has a display 236 for the clinician to focus and examine the patient's eye fundus.", "In some embodiments, the imaging system 202 has a networking unit 234.Networking unit operates to enable communication between the fundus imaging system 202 and the example display 108 or other networked devices.", "The networking unit 234 may be in wireless or wired communication with the display 108 or other networked devices.", "Additionally, the networking unit 234 is in communication with the network 110.In some embodiments, the networking unit 234 communicates with the display 108 over a wired or wireless connection.", "In some embodiments, the fundus imaging system 202 also includes an anti-aliasing filter, not pictured in FIG.", "2.The optional anti-aliasing filter is in some embodiments an optical low-pass filter.", "This filter is a thin layer located between the monochrome photodiodes 206 and the direction from which the incident light emanates.", "The filter, in some embodiments, prevents the occurrence of a pattern (moir é or other artifacts) different from the original image.", "In some embodiments, the fundus imaging system 202 also includes reflective mirrors, not shown in FIG.", "2.The optional one or more reflective mirrors are used to direct light to the image sensor array 204 and from the illumination unit 216.In some embodiments, the one or more mirrors are supported by, and fixed to, the housing.", "In other embodiments, the reflective mirror or mirrors are supported by the housing but have adjustable positions, where the clinician or computing system 222 can adjust the positioning of the mirrors.", "The example system is operable without reflective mirrors.", "FIG.", "3 is a block flow diagram of an example use 300 by a clinician of the example fundus imaging system.", "Example use 300 is performed in some embodiments by more than one clinician.", "Example use 300 includes positioning a patient 302, adjusting the focus 304, initiating a retinal imaging 306, and viewing the image 308 created by the scan.", "Other embodiments may omit steps or include additional steps.", "Example use 300 begins when the clinician positions a patient 302.The patient may be seated or standing.", "Positioning 302 includes aligning the patient such that one or more of the patient's eyes are aligned with the aperture or apertures of the fundus imaging system.", "In some embodiments, the display coupled to the imaging system shows a preview image to help guide the clinician in positioning the patient.", "In some embodiments, the system emits an audible sound to notify the clinician that the patient's eye is in a proper position.", "In some embodiments, there is a positioning structure, such as a chin rest or head support structure, to assist in positioning the patient.", "In some embodiments, the positioning structure has means for adjustment that can be used by the clinician in positioning the patient's eye relative to the housing.", "In other embodiments, the positioning structure is fixed and the housing has adjustment means such that the clinician can reposition the housing to be in alignment with the patient's eye or eyes.", "After the patient is positioned, the next step in example use 300 is for the clinician to adjust the focus 304 on the fundus imaging system.", "In some embodiments, the fundus imaging system has one or more adjustable foci.", "These foci may be manually adjusted by the clinician, electronically adjusted by the clinician, or automatically adjusted by the fundus imaging system.", "In some embodiments, the focus adjusts the position of the lens through which the incident light passes.", "In some embodiments, the focus adjusts the lens through which the light from the illumination unit passes.", "In some embodiments, the clinician initiates the automatic focusing by the fundus imaging system by pressing a button or selecting an icon on a graphical user interface.", "In some embodiments, the adjust focus step 304 can be replaced by auto focusing algorithms without human intervention.", "Next, the clinician initiates the retinal imaging 306 in example use 300.In some embodiments, the clinician initiates the retinal imaging 306 by pressing a button or selecting an icon on a graphical user interface.", "An example of the fundus imaging system's steps during retinal imaging 306 is shown in FIG.", "4 and described in detail below.", "In some embodiments, the clinician may return to step 302 to reposition the patient's other eye for imaging and repeat steps 304 and 306.In other embodiments, the clinician may view the image 308, and may ensure that the image is of acceptable quality, before returning to step 302 to image the patient's other eye.", "Additionally, in some embodiments, initiate retinal imaging 306 is replaced by passive eye tracking algorithms to automatically trigger the image capture without human intervention.", "Passive eye tracking is described with reference to FIG.", "5 below.", "After the fundus imaging system images the retina 306, the clinician views the fundus image 308 in example use 300.If any image is not satisfactory to the clinician, the clinician may repeat example use 300.Examples of the types of displays that may be used in step 308 are described in more detail with reference to block 108 in FIG.", "1.FIG.", "4 illustrates a block flow diagram of an example method of operation 400 of the fundus imaging system.", "Example operation 400 includes the fundus imaging system performing the steps of open aperture 402, adjust focus on retina 404, illuminate light-emitting diode 406, which includes illuminate red light-emitting die 408, illuminate green light-emitting die 410, and illuminate blue light-emitting die 412, control global shutter 414, which includes global reset 416, global transfer 418, sequential readout of photodiodes 420, store image read from photodiodes 422, optionally returning to the illuminate light-emitting diode step 406, process image read from photodiodes 426, send processed image to display 428, and send initial diagnosis to display 430.Alternate embodiments may have fewer or additional steps, or perform the steps in a different order.", "In example operation 400, the first step is to, optionally, open aperture 402.As described above with reference to aperture 232, in some embodiments the aperture can be a cover opened and closed through electrical or mechanical means.", "In some embodiments, the aperture is a frame that, in some embodiments, supports a lens but does not have an operable cover.", "One purpose of the open aperture step 402 is to enable incident light to pass through one or more lenses towards the image sensor array.", "Adjust focus on the retina 404 is the next step in example operation 400.In some embodiments, the clinician operating the fundus imaging system manually changes one or more focal lengths.", "Adjusting the focus can be accomplished by, for example, mechanical means such as a knob or knobs or through electrical means such as a graphical user interface displaying focus adjustment parameters, where the interface is operatively coupled to adjustment means that is coupled to the one or more lenses.", "Adjusting the focus can also be accomplished automatically by auto focusing algorithms controlling a mechanical means without human intervention.", "The next step in example operation 400 is to illuminate the light-emitting diode 406.The illuminate light-emitting diode step 406 comprises illuminating one or more of the colored dies in the red-green-blue light-emitting diode: illuminate the red die in the diode 408, illuminate the green die in the diode 410, and illuminate the blue die in the light-emitting diode 412.Other combinations of colors are possible, including, for example, cyan-magenta-yellow, red-green only or white-red only.", "As discussed above, some embodiments of the imaging system have more than one light-emitting diode.", "Additionally, in some embodiments of operation 400, the illuminate step 406 occurs either after or concurrently with the global reset step 416.The illuminate step 406 is performed multiple times, consecutively, in some embodiments.", "As discussed above, in some embodiments, one image is taken with all three dies illuminated 408, 410, and 412, producing white light.", "In some embodiments, the system initiates four consecutive image captures.", "In those embodiments, the illumination unit is configured to produce white light for the first image capture, then red, green, and blue for the subsequent image captures.", "Other sequences in other embodiments are described in more detail with reference to illumination unit 216 in FIG.", "2.The light-emitting diodes are illuminated 406 for a short period of time.", "In some embodiments, the diode, or diodes, are illuminated for less than 5 milliseconds, for less than 2 milliseconds, for less than 1 millisecond, or for less than 0.5 milliseconds.", "As discussed above, the light-emitting diode may be overdriven for some or all illuminations.", "One of many advantages of the example embodiments is that the intensity, or the period, of the light-emitting diodes can be reduced by from about 5 to about 200 times those imaging systems in the art using a rolling shutter/reset CMOS sensor.", "Control global shutter step 414 includes the global reset step 416, the global transfer step 418, and sequential readout step 420.The computing system, operatively coupled to the image sensor array, controls the image sensor array's global shutter in example operation 400.Global reset step 416 involves, in some embodiments, resetting and exposing every pixel in the image sensor array substantially simultaneously.", "The exposure of the pixels is as short as possible to avoid motion blur and to limit the amount of time the patient's pupils must be illuminated.", "In some embodiments the exposure time is about 2 milliseconds.", "Global transfer step 418 involves, in some embodiments, simultaneously ceasing the exposure of every pixel in the image sensor array and transferring the charge from each pixel into the opaque shielded storage.", "An example global shutter is described in more detail with reference to image sensor array 204 in FIG.", "2, above.", "Sequential readout step 420 in example operation 400 involves each pixel in the image sensor array being readout sequentially (one pixel after the other).", "The readout step 420 is accomplished, in some embodiments, by the computing system sending a readout clocking signal to the image sensor array to read out pixel value one by one.", "After the global transfer step 418, the pixel exposure is ended in example operation 400 and the image readout from the photodiodes' opaque shielded storage unit is stored 422 in memory.", "In some embodiments, multiple images are captured consecutively and the example operation repeats 424.Return step 424 is shown in FIG.", "4 as returning to step 406, but in other embodiments the return step 424 begins by opening the aperture 402 or by adjusting the focus on the retina 404 step.", "Next, the processor processes the image readout from the photodiodes' opaque shielded storage 426 in example operation 400.In some embodiments, processing of the image is performed in accordance with a software program stored on the memory and run in the processor.", "In some embodiments, processing 426 includes amplifying the data generated from the incident light and converting the generated data into a digital signal.", "Processing 426 may also include storing a set of digital signal values corresponding to incident light on the plurality of pixels of image sensor array as a frame of image data.", "In some embodiments, the process image step 426 does not use color demosaic algorithms.", "Process image step 426 includes a processor running image processing algorithms to, for example, perform image enhancement, perform features detection, and identify a classification to correct the diabetic retinopathy.", "For example, the algorithm can access an evaluation database for diabetic retinopathy such as DIARETDB0 and DIARETDB1, established by Lappeenrata University of Technology and University of Kuopio Medical Faculty in Finland.", "Those databases consist of about 219 fundus images that have been evaluated and annotated by experts and doctors to establish diagnosis results for those images.", "An example output of an evaluation algorithm, when using a fundus image as an input, is that small red dots exist, there are hemorrhages and hard exudates are detected in the fundus.", "The output can identify both a list of the diagnoses and the number of observed issues.", "In some embodiments, the output can also identify the detected issues on the fundus image, using, for example, graphics such as circles or arrows.", "In some embodiments, the clinician can select the one or more issues the algorithm running on the processor should identify during processing step 426.For example, in one embodiment the clinician selects through a graphical user interface “hemorrhages” in a menu containing possible diabetic retinopathy symptoms.", "The processed image then will contain identifying indicia such as on-screen arrows, circles or other identifying icons.", "Thus, where applicable, the image in this embodiment contains indicia flagging detected hemorrhages.", "But because, in this example, the clinician did not select any other symptoms, such as “exudates”, even if present, the image will not contain indicia flagging other symptoms.", "In an alternate embodiment, the processor is configured to detect all possible symptoms and the image contains indicia flagging all detected symptoms.", "Then, in some embodiments, the clinician uses a menu-type filter to select one or more symptoms to be flagged on the display.", "In another embodiment, the image stored from the photodiode readout is sent to a remote cloud storage and further processed, using algorithms described above, in a remote server.", "In example operation 400, the computing system sends the processed image to the display 428 and/or sends an initial diagnosis to display 430.As discussed above, in some embodiments, the system produces a raw image that does not contain any diagnostic identification information 428.In other embodiments, the system produces an image accompanied by diagnostic information 430.FIG.", "5 illustrates an alternate embodiment of initiate retinal imaging step 306 using passive eye tracking.", "The initiate retinal imaging step 306 operates to image the fundus of the patient P using passive eye tracking.", "In the initiate retinal imaging step 306, the fundus imaging system 202 monitors the pupil/fovea orientation of the patient P. Although the initiate retinal imaging step 306 is described with respect to fundus imaging system 202, the initiate retinal imaging step 306 may be performed using a wearable or nonwearable fundus imaging system, such as a handheld digital fundus imaging system.", "Initially, at step 303, the pupil or fovea or both of the patient P are monitored.", "The fundus imaging system 202 captures images in a first image capture mode.", "In the first image capture mode, the fundus imaging system 202 captures images at a higher frame rate.", "In some embodiments, in the first image capture mode, the fundus imaging system 202 captures images with lower illumination and at lower resolutions.", "In some embodiments, the lower illumination is created by the illumination unit 216 operating to generate and direct light of a lower intensity towards the subject.", "In other embodiments, the lower illumination is created by an external light source or ambient light.", "The first image capture mode may minimize discomfort to the patient P, allow the patient P to relax, and allow for a larger pupil size without dilation (non-mydriatic).", "Next, at step 305, the computing system 222 processes at least a portion of the images captured by the fundus imaging system 202.The computing system 222 processes the images to identify the location of the pupil or fovea or both of the patient P. Using the location of the pupil or fovea or both in one of the images, a vector corresponding to the pupil/fovea orientation is calculated.", "In some embodiments, the pupil/fovea orientation is approximated based on the distance between the pupil and fovea in the image.", "In other embodiments, the pupil/fovea orientation is calculated by approximating the position of the fovea relative to the pupil in three dimensions using estimates of the distance to the pupil and the distance between the pupil and the fovea.", "In other embodiments, the pupil/fovea orientation is approximated from the position of the pupil alone.", "In yet other embodiments, other methods of approximating the pupil/fovea orientation are used.", "Next, at step 307, the pupil/fovea orientation is compared to the optical axis of the fundus imaging system 202.If the pupil/fovea orientation is substantially aligned with the optical axis of the fundus imaging system 202, the process proceeds to step 309 to capture a fundus image.", "If not, the process returns to step 303 to continue to monitor the pupil or fovea.", "In some embodiments, the pupil/fovea orientation is substantially aligned with the optical axis when the angle between them is less than two to fifteen degrees.", "Next, at step 309, a fundus image is captured.", "In some embodiments, the fundus image is captured in a second image capture mode.", "In some embodiments, in the second image capture mode, the fundus imaging system 202 captures images with higher illumination and at higher resolutions.", "In some embodiments, the higher illumination is created by the illumination unit 216 operating to generate and direct light of a higher intensity towards the subject.", "In other embodiments, the higher illumination is created by an external light source or ambient light.", "The second image capture mode may facilitate capturing a clear, well-illuminated, and detailed fundus image.", "In some embodiments, after step 309, the initiate retinal imaging step 306 returns to step 303 to continue to monitor the pupil/fovea orientation.", "The initiate retinal imaging step 306 may continue to collect fundus images indefinitely or until a specified number of images have been collected.", "Further information regarding passive eye tracking can be found in U.S. patent application Ser.", "No.", "______, attorney docket number 10156.0082US01, titled Ophthalmoscope Device, filed on even date herewith, which is hereby incorporated by reference in its entirety.", "The flow diagrams depicted herein are just examples.", "There may be many variations to these diagrams or the steps (or operations) described therein without departing from the spirit of the disclosure.", "For instance, the steps may be performed in a differing order, or steps may be added, deleted or modified.", "While embodiments have been described, it will be understood that those skilled in the art, both now and in the future, may make various improvements and enhancements can be made." ] ]
Patent_15872680
[ [ "DEVICE, METHOD, AND GRAPHICAL USER INTERFACE FOR MANIPULATING USER INTERFACES BASED ON FINGERPRINT SENSOR INPUTS", "An electronic device with a display and a fingerprint sensor displays a fingerprint enrollment interface and detects, on the fingerprint sensor, a plurality of finger gestures performed with a finger.", "The device collects fingerprint information from the plurality of finger gestures performed with the finger.", "After collecting the fingerprint information, the device determines whether the collected fingerprint information is sufficient to enroll a fingerprint of the finger.", "When the collected fingerprint information for the finger is sufficient to enroll the fingerprint of the finger, the device enrolls the fingerprint of the finger with the device.", "When the collected fingerprint information for the finger is not sufficient to enroll the fingerprint of the finger, the device displays a message in the fingerprint enrollment interface prompting a user to perform one or more additional finger gestures on the fingerprint sensor with the finger." ], [ "1.An electronic device, comprising: a display; a biometric sensor; one or more processors; and memory storing one or more programs configured to be executed by the one or more processors, the one or more programs including instructions for: storing a set of one or more credentials; displaying a form with fields corresponding to one or more credentials of the set of one or more credentials; receiving a request to automatically fill in the form with one or more credentials of the set of one or more credentials, wherein the request includes a biometric input using the biometric sensor; in response to receiving the request to automatically fill in the form: in accordance with a determination that the biometric input includes a set of biometric information that is associated with a user who is authorized to use the set of one or more credentials, filling in the form with the one or more credentials; and in accordance with a determination that the biometric input includes a set of biometric information that is not associated with a user who is authorized to use the set of one or more credentials, forgoing filling in the form with the one or more credentials.", "2.The electronic device of claim 1, wherein the set of one or more credentials includes one or more of: a user ID, a password, a credit card number, a bank account number, an address, a telephone number, and a shopping credential.", "3.The electronic device of claim 1, wherein filling in the form with the one or more credentials includes displaying redacted versions of the one or more credentials in one or more fields of the form.", "4.The electronic device of claim 3, the one or more programs further including instructions for: while displaying the redacted versions of the one or more credentials in one or more fields of the form, detecting a respective set of biometric information on the biometric sensor; and in response to detecting the respective set of biometric information and in accordance with a determination that the respective set of biometric information is associated with a user who is authorized to reveal the one or more credentials, displaying a non-redacted version of the one or more credentials in the fields of the form.", "5.The electronic device of claim 4, wherein: the redacted version of a respective credential includes an indication of a length of the respective credential; and the non-redacted version of the respective credential includes a human readable version of the respective credential.", "6.The electronic device of claim 4, wherein: the redacted version of a respective credential includes a non-redacted portion of the respective credential; and the non-redacted version of the respective credential includes a human readable version of the entire respective credential.", "7.The electronic device of claim 1, wherein the determination that the set of biometric information is associated with a user who is authorized to use the set of one or more credentials includes a determination that the set of biometric information matches at least one or more enrolled sets of biometric information.", "8.The electronic device of claim 1, wherein the biometric sensor is a fingerprint sensor.", "9.The electronic device of claim 1, wherein the set of biometric information corresponds to a fingerprint.", "10.The electronic device of claim 1, wherein the biometric input is a finger input.", "11.A non-transitory computer-readable storage medium storing one or more programs configured to be executed by one or more processors of an electronic device with a display and a biometric sensor, the one or more programs comprising instructions for: storing a set of one or more credentials; displaying a form with fields corresponding to one or more credentials of the set of one or more credentials; receiving a request to automatically fill in the form with one or more credentials of the set of one or more credentials, wherein the request includes a biometric input on the biometric sensor; in response to receiving the request to automatically fill in the form: in accordance with a determination that the biometric input includes a set of biometric information that is associated with a user who is authorized to use the set of one or more credentials, filling in the form with the one or more credentials; and in accordance with a determination that the biometric input includes a set of biometric information that is not associated with a user who is authorized to use the set of one or more credentials, not filling in the form with the one or more credentials.", "12.A method, comprising: at an electronic device with one or more processors, memory, and a biometric sensor: storing a set of one or more credentials; displaying a form with fields corresponding to one or more credentials of the set of one or more credentials; receiving a request to automatically fill in the form with one or more credentials of the set of one or more credentials, wherein the request includes a biometric input using the biometric sensor; in response to receiving the request to automatically fill in the form: in accordance with a determination that the biometric input includes a set of biometric information that is associated with a user who is authorized to use the set of one or more credentials, filling in the form with the one or more credentials; and in accordance with a determination that the biometric input includes a set of biometric information that is not associated with a user who is authorized to use the set of one or more credentials, forgoing filling in the form with the one or more credentials." ], [ "<SOH> BACKGROUND <EOH>The use of touch-sensitive surfaces as input devices for computers and other electronic computing devices has increased significantly in recent years.", "Exemplary touch-sensitive surfaces include touch pads and touch screen displays.", "Such surfaces are widely used to manipulate user interface objects on a display.", "Additionally, some electronic devices include fingerprint sensors for authenticating users.", "Exemplary manipulations include adjusting the position and/or size of one or more user interface objects or activating buttons or opening files/applications represented by user interface objects, as well as associating metadata with one or more user interface objects or otherwise manipulating user interfaces.", "Exemplary user interface objects include digital images, video, text, icons, control elements such as buttons and other graphics.", "A user will, in some circumstances, need to perform in such manipulations on user interface objects in a file management program (e.g., Finder from Apple Inc. of Cupertino, Calif.), an image management application (e.g., Aperture or iPhoto from Apple Inc. of Cupertino, Calif.), a digital content (e.g., videos and music) management application (e.g., iTunes from Apple Inc. of Cupertino, Calif.), a drawing application, a presentation application (e.g., Keynote from Apple Inc. of Cupertino, Calif.), a word processing application (e.g., Pages from Apple Inc. of Cupertino, Calif.), a website creation application (e.g., iWeb from Apple Inc. of Cupertino, Calif.), a disk authoring application (e.g., iDVD from Apple Inc. of Cupertino, Calif.), or a spreadsheet application (e.g., Numbers from Apple Inc. of Cupertino, Calif.).", "But methods for performing these manipulations are cumbersome and inefficient.", "In addition, these methods take longer than necessary, thereby wasting energy.", "This latter consideration is particularly important in battery-operated devices." ], [ "<SOH> SUMMARY <EOH>Accordingly, there is a need for electronic devices with faster, more efficient methods and interfaces for manipulating user interfaces.", "Such methods and interfaces optionally complement or replace conventional methods for manipulating user interfaces.", "Such methods and interfaces reduce the cognitive burden on a user and produce a more efficient human-machine interface.", "For battery-operated devices, such methods and interfaces conserve power and increase the time between battery charges.", "The above deficiencies and other problems associated with user interfaces for electronic devices with touch-sensitive surfaces are reduced or eliminated by the disclosed devices.", "In some embodiments, the device is a desktop computer.", "In some embodiments, the device is portable (e.g., a notebook computer, tablet computer, or handheld device).", "In some embodiments, the device has a touchpad.", "In some embodiments, the device has a touch-sensitive display (also known as a “touch screen” or “touch screen display”).", "In some embodiments, the device has a fingerprint sensor.", "In some embodiments, the device has a graphical user interface (GUI), one or more processors, memory and one or more modules, programs or sets of instructions stored in the memory for performing multiple functions.", "In some embodiments, the user interacts with the GUI primarily through finger contacts and gestures on the touch-sensitive surface and/or the fingerprint sensor.", "In some embodiments, the functions optionally include image editing, drawing, presenting, word processing, website creating, disk authoring, spreadsheet making, game playing, telephoning, video conferencing, e-mailing, instant messaging, workout support, digital photographing, digital videoing, web browsing, digital music playing, and/or digital video playing.", "Executable instructions for performing these functions are, optionally, included in a non-transitory computer readable storage medium or other computer program product configured for execution by one or more processors.", "There is a need for electronic devices with faster, more efficient methods and interfaces for enrolling fingerprints with a device.", "Such methods and interfaces may complement or replace conventional methods for enrolling fingerprints with a device.", "Such methods and interfaces reduce the cognitive burden on a user and produce a more efficient human-machine interface.", "For battery-operated devices, such methods and interfaces conserve power and increase the time between battery charges.", "In accordance with some embodiments, a method is performed at an electronic device with a display and a fingerprint sensor.", "The method includes: displaying a fingerprint enrollment interface; detecting on the fingerprint sensor a plurality of separate and distinct stationary finger gestures performed with a respective finger; and collecting fingerprint information from the plurality of separate and distinct stationary finger gestures performed with the respective finger.", "After collecting the fingerprint information, the method includes determining, based on fingerprint information collected for the respective finger, whether the fingerprint information that has been collected is sufficient to enroll a fingerprint of the respective finger with the device.", "In accordance with a determination that the fingerprint information that has been collected for the respective finger is sufficient to enroll the fingerprint of the respective finger, the method includes enrolling the fingerprint of the respective finger with the device.", "In accordance with a determination that the fingerprint information that has been collected for the respective finger is not sufficient to enroll the fingerprint of the respective finger, the method includes displaying a message in the fingerprint enrollment interface prompting a user to perform one or more additional stationary finger gestures on the fingerprint sensor with the respective finger.", "In accordance with some embodiments, an electronic device includes: a display unit configured to display a fingerprint enrollment interface; a fingerprint sensor unit; and a processing unit coupled to the display unit and the fingerprint sensor unit.", "The processing unit is configured to: detect on the fingerprint sensor unit a plurality of separate and distinct stationary finger gestures performed with a respective finger; and collect fingerprint information from the plurality of separate and distinct stationary finger gestures performed with the respective finger.", "After collecting the fingerprint information, the processing unit is also configured to determine, based on the fingerprint information collected for the respective finger, whether the fingerprint information that has been collected is sufficient to enroll a fingerprint of the respective finger with the device.", "In accordance with a determination that the fingerprint information that has been collected for the respective finger is sufficient to enroll the fingerprint of the respective finger, the processing unit is configured to enroll the fingerprint of the respective finger with the device.", "In accordance with a determination that the fingerprint information that has been collected for the respective finger is not sufficient to enroll the fingerprint of the respective finger, the processing unit is configured to enable display of a message in the fingerprint enrollment interface prompting a user to perform one or more additional stationary finger gestures on the fingerprint sensor unit with the respective finger.", "Thus, electronic devices with displays and fingerprint sensors are provided with faster, more efficient methods and interfaces for enrolling fingerprints with a device, thereby increasing the effectiveness, efficiency, and user satisfaction with such devices.", "Such methods and interfaces may complement or replace conventional methods of enrolling fingerprints with a device.", "There is a need for electronic devices with faster, more efficient methods and interfaces for performing operations based on fingerprints.", "Such methods and interfaces may complement or replace conventional methods for performing operations.", "Such methods and interfaces reduce the cognitive burden on a user and produce a more efficient human-machine interface.", "For battery-operated devices, such methods and interfaces conserve power and increase the time between battery charges.", "In accordance with some embodiments, a method is performed at an electronic device with a fingerprint sensor.", "The method includes detecting, with the fingerprint sensor, a first input.", "The method also includes, in response to detecting the first input, determining whether the first input includes a fingerprint.", "The method further includes, in accordance with a determination that the first input includes a fingerprint: performing a first operation based on the presence of the fingerprint without regard to an identity of the fingerprint; and, in accordance with a determination that the fingerprint in the first input matches an enrolled fingerprint, conditionally performing a second operation based on the enrolled fingerprint.", "In accordance with some embodiments, an electronic device includes a fingerprint sensor unit configured to detect a first input and a processing unit coupled to the fingerprint sensor unit.", "The processing unit is configured to, in response to detecting the first input: determine whether the first input includes a fingerprint.", "The processing unit is also configured to, in accordance with a determination that the first input includes a fingerprint: perform a first operation based on the presence of the fingerprint without regard to an identity of the fingerprint.", "The processing unit is further configured to, in accordance with a determination that the fingerprint in the first input matches an enrolled fingerprint, conditionally perform a second operation based on the enrolled fingerprint.", "Thus, electronic devices with fingerprint sensors are provided with faster, more efficient methods and interfaces for performing operations based on fingerprints, thereby increasing the effectiveness, efficiency, and user satisfaction with such devices.", "Such methods and interfaces may complement or replace conventional methods for performing operations based on fingerprints.", "There is a need for electronic devices with faster, more efficient methods and interfaces for populating credential fields and revealing redacted credentials, such as passwords, credit card numbers, and the like.", "Such methods and interfaces may complement or replace conventional methods for populating credential fields and revealing redacted credentials.", "Such methods and interfaces reduce the cognitive burden on a user and produce a more efficient human-machine interface.", "For battery-operated devices, such methods and interfaces conserve power and increase the time between battery charges.", "In accordance with some embodiments, a method is performed at an electronic device with a display and a fingerprint sensor.", "The method includes: storing a set of one or more credentials; displaying a form with fields corresponding to one or more credentials of the set of one or more credentials; receiving a request to automatically fill in the form with one or more credentials of the set of one or more credentials, wherein the request includes a finger input on the fingerprint sensor; in response to receiving the request to automatically fill in the form: in accordance with a determination that the finger input includes a fingerprint that is associated with a user who is authorized to use the set of one or more credentials, filling in the form with the one or more credentials; and in accordance with a determination that the finger input includes a fingerprint that is not associated with a user who is authorized to use the set of one or more credentials, forgoing filling in the form with the one or more credentials.", "In accordance with some embodiments, an electronic device includes a display unit configured to display a form with fields corresponding to one or more credentials of the set of one or more credentials; a credential storage unit configured to store a set of one or more credentials; a fingerprint sensor unit; and a processing unit coupled to the display unit, the credential storage unit, and the fingerprint sensor unit.", "The processing unit is configured to: receive a request to automatically fill in the form with one or more credentials of the set of one or more credentials, wherein the request includes a finger input on the fingerprint sensor; and in response to receiving the request to automatically fill in the form: in accordance with a determination that the finger input includes a fingerprint that is associated with a user who is authorized to use the set of one or more credentials, fill in the form with the one or more credentials; and in accordance with a determination that the finger input includes a fingerprint that is not associated with a user who is authorized to use the set of one or more credentials, forgo filling in the form with the one or more credentials.", "In accordance with some embodiments, a method is performed at an electronic device with a display and a fingerprint sensor.", "The method includes: storing a set of one or more credentials; receiving a request to display the set of one or more credentials; in response to receiving the request to display the set of one or more credentials, displaying redacted versions of the set of one or more credentials; while displaying the redacted versions of the set of one or more credentials, detecting a fingerprint on the fingerprint sensor; and in response to detecting the fingerprint and in accordance with a determination that the fingerprint is associated with a user who is authorized to reveal the set of one or more credentials, displaying a non-redacted version of the set of one or more credentials.", "In accordance with some embodiments, an electronic device includes a display unit; a fingerprint sensor unit; and a processing unit coupled to the display unit, the credential storage unit, and the fingerprint sensor unit.", "The processing unit is configured to: receive a request to display the set of one or more credentials; in response to receiving the request to display the set of one or more credentials, enable display of redacted versions of the set of one or more credentials; and in response to detection of a fingerprint on the fingerprint sensor while the redacted versions of the set of one or more credentials are displayed, and in accordance with a determination that the fingerprint is associated with a user who is authorized to reveal the set of one or more credentials, enable display of a non-redacted version of the set of one or more credentials.", "Thus, electronic devices with displays and fingerprint sensors are provided with faster, more efficient methods and interfaces for automatically populating credential fields and revealing redacted credentials, thereby increasing the effectiveness, efficiency, and user satisfaction with such devices.", "Such methods and interfaces may complement or replace conventional methods for populating credential fields and revealing redacted credentials.", "There is a need for electronic devices with more efficient and secure methods and interfaces for managing the automatic usage of saved credentials.", "Such methods and interfaces may complement or replace conventional methods for managing the automatic usage of saved credentials.", "In accordance with some embodiments, a method is performed at an electronic device with a display and a fingerprint sensor.", "The method includes: storing on the device a respective credential of a user of the device; while executing a software application: (1) receiving a fingerprint at a fingerprint sensor of the device; and (2) in response to receiving the fingerprint and in accordance with a determination that credential-usage criteria have been satisfied, including a determination that the received fingerprint matches at least one of a set of enrolled fingerprints, automatically using the respective credential of the user in the software application.", "The method also includes: after automatically using the respective credential of the user in response to receiving the fingerprint, receiving a request to enroll an additional fingerprint with the device; in response to the request to enroll the additional fingerprint with the device, adding the additional fingerprint to the set of enrolled fingerprints; and in response to adding the additional fingerprint to the set of enrolled fingerprints, preventing enrolled fingerprints from being used to authorize automatic usage of the respective credential.", "In accordance with some embodiments, an electronic device includes a storage unit configured to store on the device a respective credential of a user of the device; and a processing unit coupled to the storage unit.", "The processing unit is configured to: while executing a software application: (1) receive a fingerprint at a fingerprint sensor of the device; and (2) in response to receiving the fingerprint and in accordance with a determination that credential-usage criteria have been satisfied, including a determination that the received fingerprint matches at least one of a set of enrolled fingerprints, automatically use the respective credential of the user in the software application.", "The processing unit is further configured to: after automatically using the respective credential of the user in response to receiving the fingerprint, receive a request to enroll an additional fingerprint with the device; in response to the request to enroll the additional fingerprint with the device, add the additional fingerprint to the set of enrolled fingerprints; and in response to adding the additional fingerprint to the set of enrolled fingerprints, prevent enrolled fingerprints from being used to authorize automatic usage of the respective credential.", "Thus, electronic devices with displays and fingerprint sensors are provided with more efficient and secure methods and interfaces for managing the automatic usage of credentials, thereby increasing the effectiveness, efficiency, and user satisfaction with such devices.", "Such methods and interfaces may complement or replace conventional methods for managing the automatic usage of credentials.", "There is a need for electronic devices with faster, more efficient methods and interfaces for revealing redacted information.", "Such methods and interfaces may complement or replace conventional methods for displaying information on a device.", "Such methods and interfaces reduce the cognitive burden on a user and produce a more efficient human-machine interface.", "For battery-operated devices, such methods and interfaces conserve power and increase the time between battery charges.", "In accordance with some embodiments, a method is performed at an electronic device with a display and a fingerprint sensor.", "The method includes: displaying a redacted version of first information on the display, and while displaying the redacted version of the first information on the display, detecting a finger input on the fingerprint sensor.", "The method further includes, in response to detecting the finger input on the fingerprint sensor: in accordance with a determination that the finger input includes a fingerprint that matches a previously enrolled fingerprint that is authorized to reveal the first information, replacing display of the redacted version of the first information with an unredacted version of the first information; and in accordance with a determination that the finger input does not include a fingerprint that matches a previously enrolled fingerprint that is authorized to reveal the first information, maintaining display of the redacted version of the first information on the display.", "In accordance with some embodiments, an electronic device includes a display unit configured to display a redacted version of first information on the display; a fingerprint sensor unit; and a processing unit coupled to the display unit and the fingerprint sensor unit.", "The processing unit is configured to, while enabling display of the redacted version of the first information on the display unit, detect a finger input on the fingerprint sensor.", "The processing unit is further configured to, in response to detecting the finger input on the fingerprint sensor: in accordance with a determination that the finger input includes a fingerprint that matches a previously enrolled fingerprint that is authorized to reveal the first information, replace display of the redacted version of the first information with an unredacted version of the first information; and in accordance with a determination that the finger input does not include a fingerprint that matches a previously enrolled fingerprint that is authorized to reveal the first information, maintain display of the redacted version of the first information on the display.", "Thus, electronic devices with displays, and fingerprint sensors are provided with faster, more efficient methods and interfaces for revealing redacted information, thereby increasing the effectiveness, efficiency, and user satisfaction with such devices.", "Such methods and interfaces may complement or replace conventional methods for displaying information on a device.", "There is a need for electronic devices with faster, more efficient methods and interfaces for providing different unlock modes of such electronic devices.", "Such methods and interfaces may complement or replace conventional methods for providing different unlock modes.", "Such methods and interfaces reduce the cognitive burden on a user and produce a more efficient human-machine interface.", "For battery-operated devices, such methods and interfaces conserve power and increase the time between battery charges.", "In accordance with some embodiments, a method is performed at an electronic device with a fingerprint sensor and a display.", "While the device is in a locked mode of operation in which access to a respective set of features of the electronic device is locked, the method includes detecting, with the fingerprint sensor, a first input that corresponds to a request to initiate unlocking the device.", "In response to detecting the first input with the fingerprint sensor, the method further includes determining whether the first input meets one of unlock criteria, first unlock-failure criteria, or second unlock-failure criteria.", "In accordance with a determination that the first input meets the unlock criteria, the method includes transitioning the device from the locked mode to an unlocked mode in which the respective set of features of the electronic device is unlocked.", "In accordance with a determination that the first input meets the first unlock-failure criteria, the method includes maintaining the device in the locked mode and adjusting unlock settings so that the device is enabled to be unlocked via an unlock operation in a first set of one or more unlock operations, and in accordance with a determination that the first input meets the second unlock-failure criteria, maintaining the device in the locked mode and adjusting unlock settings so that the device is enabled to be unlocked via an unlock operation in a second set of one or more unlock operations that is different from the first set of unlock operations.", "In accordance with some embodiments, an electronic device includes a display unit configured to display a graphical user interface, a fingerprint sensor unit and a processing unit coupled to the display unit and fingerprint sensor unit.", "While the device is in a locked mode of operation in which access to a respective set of features of the electronic device is locked, the fingerprint sensor unit detects a first input that corresponds to a request to initiate unlocking the device.", "In response to detecting the first input with the fingerprint sensor unit, the processing unit is configured to: determine whether the first input meets one of unlock criteria, first unlock-failure criteria, or second unlock-failure criteria.", "The processing unit is further configured to: in accordance with a determination that the first input meets the unlock criteria, transition the device from the locked mode to an unlocked mode in which the respective set of features of the electronic device is unlocked.", "The processing unit is further configured to: in accordance with a determination that the first input meets the first unlock-failure criteria, maintain the device in the locked mode and adjust unlock settings so that the device is enabled to be unlocked via an unlock operation in a first set of one or more unlock operations.", "The processing unit is further configured to: in accordance with a determination that the first input meets the second unlock-failure criteria, maintain the device in the locked mode and adjust unlock settings so that the device is enabled to be unlocked via an unlock operation in a second set of one or more unlock operations that is different from the first set of unlock operations.", "Thus, electronic devices with displays, and fingerprint sensors are provided with faster, more efficient methods and interfaces for providing different unlock modes, thereby increasing the effectiveness, efficiency, and user satisfaction with such devices.", "Such methods and interfaces may complement or replace conventional methods for providing different unlock modes.", "There is a need for electronic devices with more efficient and secure methods and interfaces for controlling access to device information and features and unlocking the device.", "Such methods and interfaces may complement or replace conventional methods for controlling access to device information and features and unlocking the device.", "Such methods and interfaces reduce the cognitive burden on a user and produce a more efficient human-machine interface.", "For battery-operated devices, such methods and interfaces conserve power and increase the time between battery charges.", "In accordance with some embodiments, a method is performed at an electronic device with a display and a fingerprint sensor.", "The method includes: while the device is in a locked mode in which access to a respective set of features of the electronic device is locked, displaying a first user interface on the display and detecting a first input; in response to detecting the first input, displaying a second user interface on the display, where the second user interface is in a limited-access mode in which access to the second user interface is restricted in accordance with restriction criteria; and, while displaying the second user interface in the limited-access mode: detecting a first fingerprint on the fingerprint sensor; in accordance with a determination that the first fingerprint is one of a plurality of enrolled fingerprints that are enrolled with the device, displaying the second user interface in a full-access mode in which access to the second user interface is not restricted in accordance with the restriction criteria and transitioning the device from the locked mode to an unlocked mode in which the respective set of features of the electronic device is unlocked; and in accordance with a determination that the first fingerprint is not one of the plurality of enrolled fingerprints, maintaining display of the second user interface in the limited-access mode and maintaining the device in the locked mode.", "In accordance with some embodiments, an electronic device includes a display unit, a fingerprint sensor unit, and a processing unit coupled to the display unit and the fingerprint sensor unit.", "The processing unit is configured to: while the device is in a locked mode in which access to a respective set of features of the electronic device is locked, enable display of the first user interface on the display unit, and detect a first input; in response to detecting the first input, enable display of a second user interface on the display unit, where the second user interface is in a limited-access mode in which access to the second user interface is restricted in accordance with restriction criteria; and while enabling display of the second user interface in the limited-access mode: detect a first fingerprint on the fingerprint sensor unit; in accordance with a determination that the first fingerprint is one of a plurality of enrolled fingerprints that are enrolled with the device, enable display of the second user interface in a full-access mode in which access to the second user interface is not restricted in accordance with the restriction criteria, and transition the device from the locked mode to an unlocked mode in which the respective set of features of the electronic device is unlocked; and in accordance with a determination that the first fingerprint is not one of the plurality of enrolled fingerprints, maintain display of the second user interface in the limited-access mode and maintain the device in the locked mode.", "Thus, electronic devices with displays and fingerprint sensors are provided with more efficient and secure methods and interfaces for controlling access to device information and features and unlocking the device, thereby increasing the effectiveness, efficiency, and user satisfaction with such devices.", "Such methods and interfaces may complement or replace conventional methods for controlling access to device information and features and unlocking the device.", "There is a need for electronic devices with efficient methods and interfaces for unlocking an application or a device depending on context.", "Such methods and interfaces may complement or replace conventional methods for unlocking.", "Such methods and interfaces reduce the cognitive burden on a user and produce a more efficient human-machine interface.", "For battery-operated devices, such methods and interfaces conserve power and increase the time between battery charges.", "In accordance with some embodiments, a method is performed at an electronic device with a display and a fingerprint sensor.", "The method includes: while the electronic device is in a locked mode in which access to features of a plurality of different applications on the electronic device is prevented, displaying a first user interface on the display, the first user interface being one of a locked-device user interface for the electronic device, and a limited-access user interface for a respective application in the plurality of different applications, and detecting, with the fingerprint sensor, a first input that corresponds to a request to initiate unlocking one or more features of the device.", "The method further includes, in response to detecting, with the fingerprint sensor, the first input that corresponds to the request to initiate unlocking one or more features of the device: in accordance with a determination that the first user interface is the locked-device user interface for the electronic device, transitioning the device from the locked mode to a multi-application unlocked mode in which the features of the plurality of different applications are unlocked.", "The method also includes, in accordance with a determination that the first user interface is the limited-access user interface for the respective application: transitioning the device from the locked mode to a single-application unlocked mode in which one or more previously-locked features of the respective application are unlocked; and continuing to prevent access to one or more previously-locked features of other applications in the plurality of different applications.", "In accordance with some embodiments, an electronic device includes a display unit configured to display a first user interface; a fingerprint sensor unit; and a processing unit coupled to the display unit and the fingerprint sensor unit.", "The processing unit is configured to: while the electronic device is in a locked mode in which access to features of a plurality of different applications on the electronic device is prevented: enable display of the first user interface on the display unit, the first user interface being one of: a locked-device user interface for the electronic device, and a limited-access user interface for a respective application in the plurality of different applications; and detect, with the fingerprint sensor, a first input that corresponds to a request to initiate unlocking one or more features of the device.", "The processing unit is further configured to, in response to detecting, with the fingerprint sensor, the first input that corresponds to the request to initiate unlocking one or more features of the device: in accordance with a determination that the first user interface is the locked-device user interface for the electronic device, transition the device from the locked mode to a multi-application unlocked mode in which the features of the plurality of different applications are unlocked.", "The processing unit is also configured to, in accordance with a determination that the first user interface is the limited-access user interface for the respective application: transition the device from the locked mode to a single-application unlocked mode in which one or more previously-locked features of the respective application are unlocked; and continue to prevent access to one or more previously-locked features of other applications in the plurality of different applications.", "Thus, electronic devices with displays and fingerprint sensors are provided with efficient methods and interfaces for unlocking an application or a device depending on context, thereby increasing the effectiveness, efficiency, and user satisfaction with such devices.", "Such methods and interfaces may complement or replace conventional methods for unlocking.", "In accordance with some embodiments, an electronic device includes a fingerprint sensor, a display, and/or a touch-sensitive surface, one or more processors, memory, and one or more programs; the one or more programs are stored in the memory and configured to be executed by the one or more processors and the one or more programs include instructions for performing the operations of any of the methods described above.", "In accordance with some embodiments, a graphical user interface on an electronic device with a fingerprint sensor, a display, optionally a touch-sensitive surface, a memory, and one or more processors to execute one or more programs stored in the memory includes one or more of the elements displayed in any of the methods described above, which are updated in response to inputs, as described in any of the methods described above.", "In accordance with some embodiments, a computer readable storage medium has stored therein instructions which when executed by an electronic device with a fingerprint sensor and optionally a display and/or, a touch-sensitive surface, cause the device to perform the operations of any of the methods described above.", "In accordance with some embodiments, an electronic device includes: a fingerprint sensor and optionally, a display and/one or a touch-sensitive surface; and means for performing the operations of any of the methods described above.", "In accordance with some embodiments, an information processing apparatus, for use in an electronic device with a fingerprint sensor and optionally a display and/or a touch-sensitive surface, includes means for performing the operations of any of the methods described above.", "Thus, electronic devices with displays and fingerprint sensors are provided with faster, more efficient methods and interfaces for changing beamforming parameters based on fingerprint orientation, thereby increasing the effectiveness, efficiency, and user satisfaction with such devices.", "Such methods and interfaces may complement or replace conventional methods for changing beamforming parameters." ], [ "RELATED APPLICATION This application is a continuation of U.S. patent application Ser.", "No.", "14/612,214, entitled “Device, Method, and Graphical User Interface for Manipulating User Interfaces Based on Fingerprint Sensor Inputs,” and filed Feb. 2, 2015, which is a continuation of U.S. patent application Ser.", "No.", "14/480,183, entitled “Device, Method, and Graphical User Interface for Manipulating User Interfaces Based on Fingerprint Sensor Inputs,” and filed Sep. 8, 2014, which claims priority to U.S.", "Provisional Patent Application No.", "61/875,669, entitled “Device, Method, and Graphical User Interface for Manipulating User Interfaces Based on Fingerprint Sensor Input,” and filed Sep. 9, 2013, the contents of each of which are hereby incorporated by reference in their entirety.", "TECHNICAL FIELD This relates generally to electronic devices with fingerprint sensors, including but not limited to electronic devices with fingerprint sensors that detect inputs for manipulating user interfaces.", "BACKGROUND The use of touch-sensitive surfaces as input devices for computers and other electronic computing devices has increased significantly in recent years.", "Exemplary touch-sensitive surfaces include touch pads and touch screen displays.", "Such surfaces are widely used to manipulate user interface objects on a display.", "Additionally, some electronic devices include fingerprint sensors for authenticating users.", "Exemplary manipulations include adjusting the position and/or size of one or more user interface objects or activating buttons or opening files/applications represented by user interface objects, as well as associating metadata with one or more user interface objects or otherwise manipulating user interfaces.", "Exemplary user interface objects include digital images, video, text, icons, control elements such as buttons and other graphics.", "A user will, in some circumstances, need to perform in such manipulations on user interface objects in a file management program (e.g., Finder from Apple Inc. of Cupertino, Calif.), an image management application (e.g., Aperture or iPhoto from Apple Inc. of Cupertino, Calif.), a digital content (e.g., videos and music) management application (e.g., iTunes from Apple Inc. of Cupertino, Calif.), a drawing application, a presentation application (e.g., Keynote from Apple Inc. of Cupertino, Calif.), a word processing application (e.g., Pages from Apple Inc. of Cupertino, Calif.), a website creation application (e.g., iWeb from Apple Inc. of Cupertino, Calif.), a disk authoring application (e.g., iDVD from Apple Inc. of Cupertino, Calif.), or a spreadsheet application (e.g., Numbers from Apple Inc. of Cupertino, Calif.).", "But methods for performing these manipulations are cumbersome and inefficient.", "In addition, these methods take longer than necessary, thereby wasting energy.", "This latter consideration is particularly important in battery-operated devices.", "SUMMARY Accordingly, there is a need for electronic devices with faster, more efficient methods and interfaces for manipulating user interfaces.", "Such methods and interfaces optionally complement or replace conventional methods for manipulating user interfaces.", "Such methods and interfaces reduce the cognitive burden on a user and produce a more efficient human-machine interface.", "For battery-operated devices, such methods and interfaces conserve power and increase the time between battery charges.", "The above deficiencies and other problems associated with user interfaces for electronic devices with touch-sensitive surfaces are reduced or eliminated by the disclosed devices.", "In some embodiments, the device is a desktop computer.", "In some embodiments, the device is portable (e.g., a notebook computer, tablet computer, or handheld device).", "In some embodiments, the device has a touchpad.", "In some embodiments, the device has a touch-sensitive display (also known as a “touch screen” or “touch screen display”).", "In some embodiments, the device has a fingerprint sensor.", "In some embodiments, the device has a graphical user interface (GUI), one or more processors, memory and one or more modules, programs or sets of instructions stored in the memory for performing multiple functions.", "In some embodiments, the user interacts with the GUI primarily through finger contacts and gestures on the touch-sensitive surface and/or the fingerprint sensor.", "In some embodiments, the functions optionally include image editing, drawing, presenting, word processing, website creating, disk authoring, spreadsheet making, game playing, telephoning, video conferencing, e-mailing, instant messaging, workout support, digital photographing, digital videoing, web browsing, digital music playing, and/or digital video playing.", "Executable instructions for performing these functions are, optionally, included in a non-transitory computer readable storage medium or other computer program product configured for execution by one or more processors.", "There is a need for electronic devices with faster, more efficient methods and interfaces for enrolling fingerprints with a device.", "Such methods and interfaces may complement or replace conventional methods for enrolling fingerprints with a device.", "Such methods and interfaces reduce the cognitive burden on a user and produce a more efficient human-machine interface.", "For battery-operated devices, such methods and interfaces conserve power and increase the time between battery charges.", "In accordance with some embodiments, a method is performed at an electronic device with a display and a fingerprint sensor.", "The method includes: displaying a fingerprint enrollment interface; detecting on the fingerprint sensor a plurality of separate and distinct stationary finger gestures performed with a respective finger; and collecting fingerprint information from the plurality of separate and distinct stationary finger gestures performed with the respective finger.", "After collecting the fingerprint information, the method includes determining, based on fingerprint information collected for the respective finger, whether the fingerprint information that has been collected is sufficient to enroll a fingerprint of the respective finger with the device.", "In accordance with a determination that the fingerprint information that has been collected for the respective finger is sufficient to enroll the fingerprint of the respective finger, the method includes enrolling the fingerprint of the respective finger with the device.", "In accordance with a determination that the fingerprint information that has been collected for the respective finger is not sufficient to enroll the fingerprint of the respective finger, the method includes displaying a message in the fingerprint enrollment interface prompting a user to perform one or more additional stationary finger gestures on the fingerprint sensor with the respective finger.", "In accordance with some embodiments, an electronic device includes: a display unit configured to display a fingerprint enrollment interface; a fingerprint sensor unit; and a processing unit coupled to the display unit and the fingerprint sensor unit.", "The processing unit is configured to: detect on the fingerprint sensor unit a plurality of separate and distinct stationary finger gestures performed with a respective finger; and collect fingerprint information from the plurality of separate and distinct stationary finger gestures performed with the respective finger.", "After collecting the fingerprint information, the processing unit is also configured to determine, based on the fingerprint information collected for the respective finger, whether the fingerprint information that has been collected is sufficient to enroll a fingerprint of the respective finger with the device.", "In accordance with a determination that the fingerprint information that has been collected for the respective finger is sufficient to enroll the fingerprint of the respective finger, the processing unit is configured to enroll the fingerprint of the respective finger with the device.", "In accordance with a determination that the fingerprint information that has been collected for the respective finger is not sufficient to enroll the fingerprint of the respective finger, the processing unit is configured to enable display of a message in the fingerprint enrollment interface prompting a user to perform one or more additional stationary finger gestures on the fingerprint sensor unit with the respective finger.", "Thus, electronic devices with displays and fingerprint sensors are provided with faster, more efficient methods and interfaces for enrolling fingerprints with a device, thereby increasing the effectiveness, efficiency, and user satisfaction with such devices.", "Such methods and interfaces may complement or replace conventional methods of enrolling fingerprints with a device.", "There is a need for electronic devices with faster, more efficient methods and interfaces for performing operations based on fingerprints.", "Such methods and interfaces may complement or replace conventional methods for performing operations.", "Such methods and interfaces reduce the cognitive burden on a user and produce a more efficient human-machine interface.", "For battery-operated devices, such methods and interfaces conserve power and increase the time between battery charges.", "In accordance with some embodiments, a method is performed at an electronic device with a fingerprint sensor.", "The method includes detecting, with the fingerprint sensor, a first input.", "The method also includes, in response to detecting the first input, determining whether the first input includes a fingerprint.", "The method further includes, in accordance with a determination that the first input includes a fingerprint: performing a first operation based on the presence of the fingerprint without regard to an identity of the fingerprint; and, in accordance with a determination that the fingerprint in the first input matches an enrolled fingerprint, conditionally performing a second operation based on the enrolled fingerprint.", "In accordance with some embodiments, an electronic device includes a fingerprint sensor unit configured to detect a first input and a processing unit coupled to the fingerprint sensor unit.", "The processing unit is configured to, in response to detecting the first input: determine whether the first input includes a fingerprint.", "The processing unit is also configured to, in accordance with a determination that the first input includes a fingerprint: perform a first operation based on the presence of the fingerprint without regard to an identity of the fingerprint.", "The processing unit is further configured to, in accordance with a determination that the fingerprint in the first input matches an enrolled fingerprint, conditionally perform a second operation based on the enrolled fingerprint.", "Thus, electronic devices with fingerprint sensors are provided with faster, more efficient methods and interfaces for performing operations based on fingerprints, thereby increasing the effectiveness, efficiency, and user satisfaction with such devices.", "Such methods and interfaces may complement or replace conventional methods for performing operations based on fingerprints.", "There is a need for electronic devices with faster, more efficient methods and interfaces for populating credential fields and revealing redacted credentials, such as passwords, credit card numbers, and the like.", "Such methods and interfaces may complement or replace conventional methods for populating credential fields and revealing redacted credentials.", "Such methods and interfaces reduce the cognitive burden on a user and produce a more efficient human-machine interface.", "For battery-operated devices, such methods and interfaces conserve power and increase the time between battery charges.", "In accordance with some embodiments, a method is performed at an electronic device with a display and a fingerprint sensor.", "The method includes: storing a set of one or more credentials; displaying a form with fields corresponding to one or more credentials of the set of one or more credentials; receiving a request to automatically fill in the form with one or more credentials of the set of one or more credentials, wherein the request includes a finger input on the fingerprint sensor; in response to receiving the request to automatically fill in the form: in accordance with a determination that the finger input includes a fingerprint that is associated with a user who is authorized to use the set of one or more credentials, filling in the form with the one or more credentials; and in accordance with a determination that the finger input includes a fingerprint that is not associated with a user who is authorized to use the set of one or more credentials, forgoing filling in the form with the one or more credentials.", "In accordance with some embodiments, an electronic device includes a display unit configured to display a form with fields corresponding to one or more credentials of the set of one or more credentials; a credential storage unit configured to store a set of one or more credentials; a fingerprint sensor unit; and a processing unit coupled to the display unit, the credential storage unit, and the fingerprint sensor unit.", "The processing unit is configured to: receive a request to automatically fill in the form with one or more credentials of the set of one or more credentials, wherein the request includes a finger input on the fingerprint sensor; and in response to receiving the request to automatically fill in the form: in accordance with a determination that the finger input includes a fingerprint that is associated with a user who is authorized to use the set of one or more credentials, fill in the form with the one or more credentials; and in accordance with a determination that the finger input includes a fingerprint that is not associated with a user who is authorized to use the set of one or more credentials, forgo filling in the form with the one or more credentials.", "In accordance with some embodiments, a method is performed at an electronic device with a display and a fingerprint sensor.", "The method includes: storing a set of one or more credentials; receiving a request to display the set of one or more credentials; in response to receiving the request to display the set of one or more credentials, displaying redacted versions of the set of one or more credentials; while displaying the redacted versions of the set of one or more credentials, detecting a fingerprint on the fingerprint sensor; and in response to detecting the fingerprint and in accordance with a determination that the fingerprint is associated with a user who is authorized to reveal the set of one or more credentials, displaying a non-redacted version of the set of one or more credentials.", "In accordance with some embodiments, an electronic device includes a display unit; a fingerprint sensor unit; and a processing unit coupled to the display unit, the credential storage unit, and the fingerprint sensor unit.", "The processing unit is configured to: receive a request to display the set of one or more credentials; in response to receiving the request to display the set of one or more credentials, enable display of redacted versions of the set of one or more credentials; and in response to detection of a fingerprint on the fingerprint sensor while the redacted versions of the set of one or more credentials are displayed, and in accordance with a determination that the fingerprint is associated with a user who is authorized to reveal the set of one or more credentials, enable display of a non-redacted version of the set of one or more credentials.", "Thus, electronic devices with displays and fingerprint sensors are provided with faster, more efficient methods and interfaces for automatically populating credential fields and revealing redacted credentials, thereby increasing the effectiveness, efficiency, and user satisfaction with such devices.", "Such methods and interfaces may complement or replace conventional methods for populating credential fields and revealing redacted credentials.", "There is a need for electronic devices with more efficient and secure methods and interfaces for managing the automatic usage of saved credentials.", "Such methods and interfaces may complement or replace conventional methods for managing the automatic usage of saved credentials.", "In accordance with some embodiments, a method is performed at an electronic device with a display and a fingerprint sensor.", "The method includes: storing on the device a respective credential of a user of the device; while executing a software application: (1) receiving a fingerprint at a fingerprint sensor of the device; and (2) in response to receiving the fingerprint and in accordance with a determination that credential-usage criteria have been satisfied, including a determination that the received fingerprint matches at least one of a set of enrolled fingerprints, automatically using the respective credential of the user in the software application.", "The method also includes: after automatically using the respective credential of the user in response to receiving the fingerprint, receiving a request to enroll an additional fingerprint with the device; in response to the request to enroll the additional fingerprint with the device, adding the additional fingerprint to the set of enrolled fingerprints; and in response to adding the additional fingerprint to the set of enrolled fingerprints, preventing enrolled fingerprints from being used to authorize automatic usage of the respective credential.", "In accordance with some embodiments, an electronic device includes a storage unit configured to store on the device a respective credential of a user of the device; and a processing unit coupled to the storage unit.", "The processing unit is configured to: while executing a software application: (1) receive a fingerprint at a fingerprint sensor of the device; and (2) in response to receiving the fingerprint and in accordance with a determination that credential-usage criteria have been satisfied, including a determination that the received fingerprint matches at least one of a set of enrolled fingerprints, automatically use the respective credential of the user in the software application.", "The processing unit is further configured to: after automatically using the respective credential of the user in response to receiving the fingerprint, receive a request to enroll an additional fingerprint with the device; in response to the request to enroll the additional fingerprint with the device, add the additional fingerprint to the set of enrolled fingerprints; and in response to adding the additional fingerprint to the set of enrolled fingerprints, prevent enrolled fingerprints from being used to authorize automatic usage of the respective credential.", "Thus, electronic devices with displays and fingerprint sensors are provided with more efficient and secure methods and interfaces for managing the automatic usage of credentials, thereby increasing the effectiveness, efficiency, and user satisfaction with such devices.", "Such methods and interfaces may complement or replace conventional methods for managing the automatic usage of credentials.", "There is a need for electronic devices with faster, more efficient methods and interfaces for revealing redacted information.", "Such methods and interfaces may complement or replace conventional methods for displaying information on a device.", "Such methods and interfaces reduce the cognitive burden on a user and produce a more efficient human-machine interface.", "For battery-operated devices, such methods and interfaces conserve power and increase the time between battery charges.", "In accordance with some embodiments, a method is performed at an electronic device with a display and a fingerprint sensor.", "The method includes: displaying a redacted version of first information on the display, and while displaying the redacted version of the first information on the display, detecting a finger input on the fingerprint sensor.", "The method further includes, in response to detecting the finger input on the fingerprint sensor: in accordance with a determination that the finger input includes a fingerprint that matches a previously enrolled fingerprint that is authorized to reveal the first information, replacing display of the redacted version of the first information with an unredacted version of the first information; and in accordance with a determination that the finger input does not include a fingerprint that matches a previously enrolled fingerprint that is authorized to reveal the first information, maintaining display of the redacted version of the first information on the display.", "In accordance with some embodiments, an electronic device includes a display unit configured to display a redacted version of first information on the display; a fingerprint sensor unit; and a processing unit coupled to the display unit and the fingerprint sensor unit.", "The processing unit is configured to, while enabling display of the redacted version of the first information on the display unit, detect a finger input on the fingerprint sensor.", "The processing unit is further configured to, in response to detecting the finger input on the fingerprint sensor: in accordance with a determination that the finger input includes a fingerprint that matches a previously enrolled fingerprint that is authorized to reveal the first information, replace display of the redacted version of the first information with an unredacted version of the first information; and in accordance with a determination that the finger input does not include a fingerprint that matches a previously enrolled fingerprint that is authorized to reveal the first information, maintain display of the redacted version of the first information on the display.", "Thus, electronic devices with displays, and fingerprint sensors are provided with faster, more efficient methods and interfaces for revealing redacted information, thereby increasing the effectiveness, efficiency, and user satisfaction with such devices.", "Such methods and interfaces may complement or replace conventional methods for displaying information on a device.", "There is a need for electronic devices with faster, more efficient methods and interfaces for providing different unlock modes of such electronic devices.", "Such methods and interfaces may complement or replace conventional methods for providing different unlock modes.", "Such methods and interfaces reduce the cognitive burden on a user and produce a more efficient human-machine interface.", "For battery-operated devices, such methods and interfaces conserve power and increase the time between battery charges.", "In accordance with some embodiments, a method is performed at an electronic device with a fingerprint sensor and a display.", "While the device is in a locked mode of operation in which access to a respective set of features of the electronic device is locked, the method includes detecting, with the fingerprint sensor, a first input that corresponds to a request to initiate unlocking the device.", "In response to detecting the first input with the fingerprint sensor, the method further includes determining whether the first input meets one of unlock criteria, first unlock-failure criteria, or second unlock-failure criteria.", "In accordance with a determination that the first input meets the unlock criteria, the method includes transitioning the device from the locked mode to an unlocked mode in which the respective set of features of the electronic device is unlocked.", "In accordance with a determination that the first input meets the first unlock-failure criteria, the method includes maintaining the device in the locked mode and adjusting unlock settings so that the device is enabled to be unlocked via an unlock operation in a first set of one or more unlock operations, and in accordance with a determination that the first input meets the second unlock-failure criteria, maintaining the device in the locked mode and adjusting unlock settings so that the device is enabled to be unlocked via an unlock operation in a second set of one or more unlock operations that is different from the first set of unlock operations.", "In accordance with some embodiments, an electronic device includes a display unit configured to display a graphical user interface, a fingerprint sensor unit and a processing unit coupled to the display unit and fingerprint sensor unit.", "While the device is in a locked mode of operation in which access to a respective set of features of the electronic device is locked, the fingerprint sensor unit detects a first input that corresponds to a request to initiate unlocking the device.", "In response to detecting the first input with the fingerprint sensor unit, the processing unit is configured to: determine whether the first input meets one of unlock criteria, first unlock-failure criteria, or second unlock-failure criteria.", "The processing unit is further configured to: in accordance with a determination that the first input meets the unlock criteria, transition the device from the locked mode to an unlocked mode in which the respective set of features of the electronic device is unlocked.", "The processing unit is further configured to: in accordance with a determination that the first input meets the first unlock-failure criteria, maintain the device in the locked mode and adjust unlock settings so that the device is enabled to be unlocked via an unlock operation in a first set of one or more unlock operations.", "The processing unit is further configured to: in accordance with a determination that the first input meets the second unlock-failure criteria, maintain the device in the locked mode and adjust unlock settings so that the device is enabled to be unlocked via an unlock operation in a second set of one or more unlock operations that is different from the first set of unlock operations.", "Thus, electronic devices with displays, and fingerprint sensors are provided with faster, more efficient methods and interfaces for providing different unlock modes, thereby increasing the effectiveness, efficiency, and user satisfaction with such devices.", "Such methods and interfaces may complement or replace conventional methods for providing different unlock modes.", "There is a need for electronic devices with more efficient and secure methods and interfaces for controlling access to device information and features and unlocking the device.", "Such methods and interfaces may complement or replace conventional methods for controlling access to device information and features and unlocking the device.", "Such methods and interfaces reduce the cognitive burden on a user and produce a more efficient human-machine interface.", "For battery-operated devices, such methods and interfaces conserve power and increase the time between battery charges.", "In accordance with some embodiments, a method is performed at an electronic device with a display and a fingerprint sensor.", "The method includes: while the device is in a locked mode in which access to a respective set of features of the electronic device is locked, displaying a first user interface on the display and detecting a first input; in response to detecting the first input, displaying a second user interface on the display, where the second user interface is in a limited-access mode in which access to the second user interface is restricted in accordance with restriction criteria; and, while displaying the second user interface in the limited-access mode: detecting a first fingerprint on the fingerprint sensor; in accordance with a determination that the first fingerprint is one of a plurality of enrolled fingerprints that are enrolled with the device, displaying the second user interface in a full-access mode in which access to the second user interface is not restricted in accordance with the restriction criteria and transitioning the device from the locked mode to an unlocked mode in which the respective set of features of the electronic device is unlocked; and in accordance with a determination that the first fingerprint is not one of the plurality of enrolled fingerprints, maintaining display of the second user interface in the limited-access mode and maintaining the device in the locked mode.", "In accordance with some embodiments, an electronic device includes a display unit, a fingerprint sensor unit, and a processing unit coupled to the display unit and the fingerprint sensor unit.", "The processing unit is configured to: while the device is in a locked mode in which access to a respective set of features of the electronic device is locked, enable display of the first user interface on the display unit, and detect a first input; in response to detecting the first input, enable display of a second user interface on the display unit, where the second user interface is in a limited-access mode in which access to the second user interface is restricted in accordance with restriction criteria; and while enabling display of the second user interface in the limited-access mode: detect a first fingerprint on the fingerprint sensor unit; in accordance with a determination that the first fingerprint is one of a plurality of enrolled fingerprints that are enrolled with the device, enable display of the second user interface in a full-access mode in which access to the second user interface is not restricted in accordance with the restriction criteria, and transition the device from the locked mode to an unlocked mode in which the respective set of features of the electronic device is unlocked; and in accordance with a determination that the first fingerprint is not one of the plurality of enrolled fingerprints, maintain display of the second user interface in the limited-access mode and maintain the device in the locked mode.", "Thus, electronic devices with displays and fingerprint sensors are provided with more efficient and secure methods and interfaces for controlling access to device information and features and unlocking the device, thereby increasing the effectiveness, efficiency, and user satisfaction with such devices.", "Such methods and interfaces may complement or replace conventional methods for controlling access to device information and features and unlocking the device.", "There is a need for electronic devices with efficient methods and interfaces for unlocking an application or a device depending on context.", "Such methods and interfaces may complement or replace conventional methods for unlocking.", "Such methods and interfaces reduce the cognitive burden on a user and produce a more efficient human-machine interface.", "For battery-operated devices, such methods and interfaces conserve power and increase the time between battery charges.", "In accordance with some embodiments, a method is performed at an electronic device with a display and a fingerprint sensor.", "The method includes: while the electronic device is in a locked mode in which access to features of a plurality of different applications on the electronic device is prevented, displaying a first user interface on the display, the first user interface being one of a locked-device user interface for the electronic device, and a limited-access user interface for a respective application in the plurality of different applications, and detecting, with the fingerprint sensor, a first input that corresponds to a request to initiate unlocking one or more features of the device.", "The method further includes, in response to detecting, with the fingerprint sensor, the first input that corresponds to the request to initiate unlocking one or more features of the device: in accordance with a determination that the first user interface is the locked-device user interface for the electronic device, transitioning the device from the locked mode to a multi-application unlocked mode in which the features of the plurality of different applications are unlocked.", "The method also includes, in accordance with a determination that the first user interface is the limited-access user interface for the respective application: transitioning the device from the locked mode to a single-application unlocked mode in which one or more previously-locked features of the respective application are unlocked; and continuing to prevent access to one or more previously-locked features of other applications in the plurality of different applications.", "In accordance with some embodiments, an electronic device includes a display unit configured to display a first user interface; a fingerprint sensor unit; and a processing unit coupled to the display unit and the fingerprint sensor unit.", "The processing unit is configured to: while the electronic device is in a locked mode in which access to features of a plurality of different applications on the electronic device is prevented: enable display of the first user interface on the display unit, the first user interface being one of: a locked-device user interface for the electronic device, and a limited-access user interface for a respective application in the plurality of different applications; and detect, with the fingerprint sensor, a first input that corresponds to a request to initiate unlocking one or more features of the device.", "The processing unit is further configured to, in response to detecting, with the fingerprint sensor, the first input that corresponds to the request to initiate unlocking one or more features of the device: in accordance with a determination that the first user interface is the locked-device user interface for the electronic device, transition the device from the locked mode to a multi-application unlocked mode in which the features of the plurality of different applications are unlocked.", "The processing unit is also configured to, in accordance with a determination that the first user interface is the limited-access user interface for the respective application: transition the device from the locked mode to a single-application unlocked mode in which one or more previously-locked features of the respective application are unlocked; and continue to prevent access to one or more previously-locked features of other applications in the plurality of different applications.", "Thus, electronic devices with displays and fingerprint sensors are provided with efficient methods and interfaces for unlocking an application or a device depending on context, thereby increasing the effectiveness, efficiency, and user satisfaction with such devices.", "Such methods and interfaces may complement or replace conventional methods for unlocking.", "In accordance with some embodiments, an electronic device includes a fingerprint sensor, a display, and/or a touch-sensitive surface, one or more processors, memory, and one or more programs; the one or more programs are stored in the memory and configured to be executed by the one or more processors and the one or more programs include instructions for performing the operations of any of the methods described above.", "In accordance with some embodiments, a graphical user interface on an electronic device with a fingerprint sensor, a display, optionally a touch-sensitive surface, a memory, and one or more processors to execute one or more programs stored in the memory includes one or more of the elements displayed in any of the methods described above, which are updated in response to inputs, as described in any of the methods described above.", "In accordance with some embodiments, a computer readable storage medium has stored therein instructions which when executed by an electronic device with a fingerprint sensor and optionally a display and/or, a touch-sensitive surface, cause the device to perform the operations of any of the methods described above.", "In accordance with some embodiments, an electronic device includes: a fingerprint sensor and optionally, a display and/one or a touch-sensitive surface; and means for performing the operations of any of the methods described above.", "In accordance with some embodiments, an information processing apparatus, for use in an electronic device with a fingerprint sensor and optionally a display and/or a touch-sensitive surface, includes means for performing the operations of any of the methods described above.", "Thus, electronic devices with displays and fingerprint sensors are provided with faster, more efficient methods and interfaces for changing beamforming parameters based on fingerprint orientation, thereby increasing the effectiveness, efficiency, and user satisfaction with such devices.", "Such methods and interfaces may complement or replace conventional methods for changing beamforming parameters.", "BRIEF DESCRIPTION OF THE DRAWINGS For a better understanding of the various described embodiments, reference should be made to the Description of Embodiments below, in conjunction with the following drawings in which like reference numerals refer to corresponding parts throughout the figures.", "FIG.", "1A is a block diagram illustrating a portable multifunction device with a touch-sensitive display and a fingerprint sensor in accordance with some embodiments.", "FIG.", "1B is a block diagram illustrating exemplary components for event handling in accordance with some embodiments.", "FIG.", "2 illustrates a portable multifunction device having a touch screen and a fingerprint sensor in accordance with some embodiments.", "FIG.", "3 is a block diagram of an exemplary multifunction device with a display and a plurality of sensors including a fingerprint sensor and, optionally a touch-sensitive surface in accordance with some embodiments.", "FIG.", "4A illustrates an exemplary user interface for a menu of applications on a portable multifunction device in accordance with some embodiments.", "FIG.", "4B illustrates an exemplary user interface for a multifunction device with a fingerprint sensor and a touch-sensitive surface that is separate from the display in accordance with some embodiments.", "FIG.", "4C illustrates a schematic representation of a two hands with associated fingerprints in accordance with some embodiments.", "FIG.", "4D illustrates different types of rotation of a fingerprint on a fingerprint sensor in accordance with some embodiments.", "FIGS.", "5A-5EE illustrate exemplary user interfaces for enrolling fingerprints with a device in accordance with some embodiments.", "FIGS.", "6A-6D are flow diagrams illustrating a method of enrolling fingerprints with a device in accordance with some embodiments.", "FIG.", "7 is a functional block diagram of an electronic device in accordance with some embodiments.", "FIGS.", "8A-8W illustrate exemplary user interfaces for performing operations based on fingerprints in accordance with some embodiments.", "FIGS.", "9A-9B are flow diagrams illustrating a method of performing operations based on fingerprints in accordance with some embodiments.", "FIG.", "10 is a functional block diagram of an electronic device in accordance with some embodiments.", "FIGS.", "11A-11D illustrate exemplary user interfaces for populating credential fields with credentials, and for displaying non-redacted versions of credentials, in response to fingerprint-based authentication of a user, in accordance with some embodiments.", "FIGS.", "12A-12B are flow diagrams illustrating methods for using fingerprint-based authentication of a user to authorize automatic population of credential fields and to authorize display of non-redacted versions of credentials, in accordance with some embodiments.", "FIG.", "13 is a functional block diagram of an electronic device, in accordance with some embodiments.", "FIGS.", "14A-14C illustrate exemplary user interfaces for displaying non-redacted versions of credentials in response to fingerprint-based authentication of a user, in accordance with some embodiments.", "FIGS.", "15A-15B are flow diagrams illustrating methods for using fingerprint-based authentication of a user to authorize display of non-redacted versions of credentials, in accordance with some embodiments.", "FIG.", "16 is a functional block diagram of an electronic device, in accordance with some embodiments.", "FIGS.", "17A-17J illustrate exemplary user interfaces for managing the automatic usage of a saved credential through enrolled fingerprints in accordance with some embodiments.", "FIGS.", "18A-18C are flow diagrams illustrating a method of managing the automatic usage of a saved credential through enrolled fingerprints in accordance with some embodiments.", "FIG.", "19 is a functional block diagram of an electronic device in accordance with some embodiments.", "FIGS.", "20A-20T illustrate exemplary user interfaces for revealing redacted information in accordance with some embodiments.", "FIGS.", "21A-21C are flow diagrams illustrating a method of revealing redacted information in accordance with some embodiments.", "FIG.", "22 is a functional block diagram of an electronic device in accordance with some embodiments.", "FIGS.", "23A-23FF illustrate exemplary user interfaces for providing different unlock modes in accordance with some embodiments.", "FIGS.", "24A-24D are flow diagrams illustrating a method of providing different unlock modes in accordance with some embodiments.", "FIG.", "25 is a functional block diagram of an electronic device in accordance with some embodiments.", "FIGS.", "26A-26X illustrate exemplary user interfaces for controlling access to device information and features and unlocking the device in accordance with some embodiments.", "FIGS.", "27A-27D are flow diagrams illustrating a method of controlling access to device information and features and unlocking the device in accordance with some embodiments.", "FIG.", "28 is a functional block diagram of an electronic device in accordance with some embodiments.", "FIGS.", "29A-29Y illustrate exemplary user interfaces for unlocking an application or a device depending on context in accordance with some embodiments.", "FIGS.", "30A-30D are flow diagrams illustrating a method of unlocking an application or a device depending on context in accordance with some embodiments.", "FIG.", "31 is a functional block diagram of an electronic device in accordance with some embodiments.", "DESCRIPTION OF EMBODIMENTS The methods, devices and GUIs described herein respond to inputs on a fingerprint sensor instead of, or in addition to, inputs on a touch-sensitive surface or other input device.", "In some implementations, a touch-sensitive surface with a spatial resolution that is high enough to detect fingerprint features formed by individual fingerprint ridges is used as a fingerprint sensor.", "When a fingerprint sensor is used without a separate touch-sensitive surface, the fingerprint sensor can serve as a substitute for many of the functions of the touch-sensitive surface with a much smaller form factor, as the fingerprint sensor can detect movement of a contact over the fingerprint sensor even when the fingerprint has an area that is as large as or larger than the area of the fingerprint sensor.", "When a fingerprint sensor is used in addition to a separate touch-sensitive surface, the fingerprint sensor can augment the touch-sensitive surface by providing accurate detection of twisting motions of a contact, identifying different fingerprints of fingers that are used to perform gestures on the fingerprint sensor, and identifying a current user of the device.", "Additionally, when a fingerprint sensor is used in addition to a separate touchscreen display, the fingerprint sensor can detect touch inputs in situations where it is advantageous to avoid having fingers obscuring portions of the display (e.g., while viewing a map, a video or a game).", "When the touch-sensitive surface is used as a fingerprint sensor, the touch-sensitive surface optionally has spatial resolution settings that can be defined so as to switch the touch-sensitive surface (or regions of the touch-sensitive surface) between a low-resolution mode and a high-resolution mode automatically, without user intervention.", "In many situations the low-resolution mode consumes less power than the high-resolution mode.", "An advantage of operating the touch-sensitive surface in a low-resolution mode when fingerprint detection is not needed and switching the touch-sensitive surface, or a region of the touch-sensitive surface, to high-resolution mode on an as-needed basis is that such an approach conserves power while still providing high-resolution fingerprint feature sensing as-needed to improve the user experience of using the device.", "In implementations where the touch-sensitive surface is used as a fingerprint sensor, the term “fingerprint sensor” is used to refer to the touch-sensitive surface, or a region of the touch-sensitive surface, that is currently in high-resolution mode.", "A number of different approaches to providing an intuitive user interface where inputs from one or more fingerprint sensors are used to manipulate a user interface of an electronic device are described below.", "Using one or more of these approaches (optionally in conjunction with each other) helps to provide a user interface that intuitively provides users with additional information and functionality, thereby reducing the user's cognitive burden and improving the human-machine interface.", "Such improvements in the human-machine interface enable users to use the device faster and more efficiently.", "For battery-operated devices, these improvements conserve power and increase the time between battery charges.", "For ease of explanation, systems, methods and user interfaces for including illustrative examples of some of these approaches are described below, as follows: Below, FIGS.", "5A-5EE illustrate exemplary user interfaces for enrolling fingerprints with a device.", "FIGS.", "6A-6D are flow diagrams illustrating a method of enrolling fingerprints with a device.", "The user interfaces in FIGS.", "5A-5EE are used to illustrate the processes in FIGS.", "6A-6D.", "Below, FIGS.", "8A-8W illustrate exemplary user interfaces for performing operations based on fingerprints.", "FIGS.", "9A-9B are flow diagrams illustrating a method of performing operations based on fingerprints.", "The user interfaces in FIGS.", "8A-8W are used to illustrate the processes in FIGS.", "9A-9B.", "Below, FIGS.", "11A-11D and 14A-14C illustrate exemplary user interfaces for populating credential fields with credentials, and for displaying non-redacted versions of credentials, in response to fingerprint-based authentication of a user.", "FIGS.", "12A-12B and 15A-15B are flow diagrams illustrating methods for using fingerprint-based authentication of a user to authorize automatic population of credential fields and/or to authorize display of non-redacted credentials.", "The user interfaces in FIGS.", "11A-11D and 14A-14C are used to illustrate the processes in FIGS.", "12A-12B and 15A-15B.", "Below, FIGS.", "17A-17J illustrate exemplary user interfaces for managing automatic usage of saved credentials on an electronic device (e.g., device 100 or 300).", "FIGS.", "18A-18C are flow diagrams illustrating a method of managing automatic usage of saved credentials on an electronic device (e.g., device 100 or 300).", "The user interfaces in FIGS.", "17A-17J are used to illustrate the processes in FIGS.", "18A-18C.", "Below, FIGS.", "20A-20T illustrate exemplary user interfaces for revealing redacted information.", "FIGS.", "21A-21C are flow diagrams illustrating a method of revealing redacted information.", "The user interfaces in FIGS.", "20A-20T are used to illustrate the processes in FIGS.", "21A-21C.", "Below, FIGS.", "23A-23FF illustrate exemplary user interfaces for providing different unlock modes on an electronic device.", "FIGS.", "24A-24D are flow diagrams illustrating a method of providing different unlock modes on an electronic device.", "The user interfaces in FIGS.", "23A-23FF are used to illustrate the processes in FIGS.", "24A-24D.", "Below, FIGS.", "26A-26X illustrate exemplary user interfaces for controlling access to device information and features and unlocking the device.", "FIGS.", "27A-27D are flow diagrams illustrating a method of unlocking a device and access to device features.", "The user interfaces in FIGS.", "26A-26X are used to illustrate the processes in FIGS.", "27A-27D.", "Below, FIGS.", "29A-29Y illustrate exemplary user interfaces for unlocking an application or a device depending on context.", "FIGS.", "30A-30D are flow diagrams illustrating a method of unlocking an application or a device depending on context.", "The user interfaces in FIGS.", "29A-29Y are used to illustrate the processes in FIGS.", "30A-30D.", "Exemplary Devices Reference will now be made in detail to embodiments, examples of which are illustrated in the accompanying drawings.", "In the following detailed description, numerous specific details are set forth in order to provide a thorough understanding of the various described embodiments.", "However, it will be apparent to one of ordinary skill in the art that the various described embodiments may be practiced without these specific details.", "In other instances, well-known methods, procedures, components, circuits, and networks have not been described in detail so as not to unnecessarily obscure aspects of the embodiments.", "It will also be understood that, although the terms first, second, etc.", "are, in some instances, used herein to describe various elements, these elements should not be limited by these terms.", "These terms are only used to distinguish one element from another.", "For example, a first contact could be termed a second contact, and, similarly, a second contact could be termed a first contact, without departing from the scope of the various described embodiments.", "The first contact and the second contact are both contacts, but they are not the same contact.", "The terminology used in the description of the various described embodiments herein is for the purpose of describing particular embodiments only and is not intended to be limiting.", "As used in the description of the various described embodiments and the appended claims, the singular forms “a”, “an” and “the” are intended to include the plural forms as well, unless the context clearly indicates otherwise.", "It will also be understood that the term “and/or” as used herein refers to and encompasses any and all possible combinations of one or more of the associated listed items.", "It will be further understood that the terms “includes,” “including,” “comprises,” and/or “comprising,” when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.", "As used herein, the term “if” is, optionally, construed to mean “when” or “upon” or “in response to determining” or “in response to detecting,” depending on the context.", "Similarly, the phrase “if it is determined” or “if [a stated condition or event] is detected” is, optionally, construed to mean “upon determining” or “in response to determining” or “upon detecting [the stated condition or event]” or “in response to detecting [the stated condition or event],” depending on the context.", "Embodiments of electronic devices, user interfaces for such devices, and associated processes for using such devices are described.", "In some embodiments, the device is a portable communications device, such as a mobile telephone, that also contains other functions, such as PDA and/or music player functions.", "Exemplary embodiments of portable multifunction devices include, without limitation, the iPhone®, iPod Touch®, and iPad® devices from Apple Inc. of Cupertino, Calif. Other portable electronic devices, such as laptops or tablet computers with touch-sensitive surfaces (e.g., touch screen displays and/or touch pads), are, optionally, used.", "It should also be understood that, in some embodiments, the device is not a portable communications device, but is a desktop computer with a touch-sensitive surface (e.g., a touch screen display and/or a touch pad).", "In the discussion that follows, an electronic device that includes a display and a touch-sensitive surface is described.", "It should be understood, however, that the electronic device optionally includes one or more other physical user-interface devices, such as a physical keyboard, a mouse and/or a joystick.", "The device typically supports a variety of applications, such as one or more of the following: a drawing application, a presentation application, a word processing application, a website creation application, a disk authoring application, a spreadsheet application, a gaming application, a telephone application, a video conferencing application, an e-mail application, an instant messaging application, a workout support application, a photo management application, a digital camera application, a digital video camera application, a web browsing application, a digital music player application, and/or a digital video player application.", "The various applications that are executed on the device optionally use at least one common physical user-interface device, such as the touch-sensitive surface.", "One or more functions of the touch-sensitive surface as well as corresponding information displayed on the device are, optionally, adjusted and/or varied from one application to the next and/or within a respective application.", "In this way, a common physical architecture (such as the touch-sensitive surface) of the device optionally supports the variety of applications with user interfaces that are intuitive and transparent to the user.", "Attention is now directed toward embodiments of portable devices with touch-sensitive displays.", "FIG.", "1A is a block diagram illustrating portable multifunction device 100 with touch-sensitive displays 112 in accordance with some embodiments.", "Touch-sensitive display 112 is sometimes called a “touch screen” for convenience, and is sometimes known as or called a touch-sensitive display system.", "Device 100 includes memory 102 (which optionally includes one or more computer readable storage mediums), memory controller 122, one or more processing units (CPU's) 120, peripherals interface 118, RF circuitry 108, audio circuitry 110, speaker 111, microphone 113, input/output (I/O) subsystem 106, other input or control devices 116, and external port 124.Device 100 optionally includes one or more optical sensors 164.Device 100 optionally includes one or more intensity sensors 165 for detecting intensity of contacts on device 100 (e.g., a touch-sensitive surface such as touch-sensitive display system 112 of device 100).", "Device 100 optionally includes one or more tactile output generators 167 for generating tactile outputs on device 100 (e.g., generating tactile outputs on a touch-sensitive surface such as touch-sensitive display system 112 of device 100 or touchpad 355 of device 300).", "These components optionally communicate over one or more communication buses or signal lines 103.As used in the specification and claims, the term “intensity” of a contact on a touch-sensitive surface refers to the force or pressure (force per unit area) of a contact (e.g., a finger contact) on the touch sensitive surface, or to a substitute (proxy) for the force or pressure of a contact on the touch sensitive surface.", "The intensity of a contact has a range of values that includes at least four distinct values and more typically includes hundreds of distinct values (e.g., at least 256).", "Intensity of a contact is, optionally, determined (or measured) using various approaches and various sensors or combinations of sensors.", "For example, one or more force sensors underneath or adjacent to the touch-sensitive surface are, optionally, used to measure force at various points on the touch-sensitive surface.", "In some implementations, force measurements from multiple force sensors are combined (e.g., a weighted average) to determine an estimated force of a contact.", "Similarly, a pressure-sensitive tip of a stylus is, optionally, used to determine a pressure of the stylus on the touch-sensitive surface.", "Alternatively, the size of the contact area detected on the touch-sensitive surface and/or changes thereto, the capacitance of the touch-sensitive surface proximate to the contact and/or changes thereto, and/or the resistance of the touch-sensitive surface proximate to the contact and/or changes thereto are, optionally, used as a substitute for the force or pressure of the contact on the touch-sensitive surface.", "In some implementations, the substitute measurements for contact force or pressure are used directly to determine whether an intensity threshold has been exceeded (e.g., the intensity threshold is described in units corresponding to the substitute measurements).", "In some implementations, the substitute measurements for contact force or pressure are converted to an estimated force or pressure and the estimated force or pressure is used to determine whether an intensity threshold has been exceeded (e.g., the intensity threshold is a pressure threshold measured in units of pressure).", "As used in the specification and claims, the term “tactile output” refers to physical displacement of a device relative to a previous position of the device, physical displacement of a component (e.g., a touch-sensitive surface) of a device relative to another component (e.g., housing) of the device, or displacement of the component relative to a center of mass of the device that will be detected by a user with the user's sense of touch.", "For example, in situations where the device or the component of the device is in contact with a surface of a user that is sensitive to touch (e.g., a finger, palm, or other part of a user's hand), the tactile output generated by the physical displacement will be interpreted by the user as a tactile sensation corresponding to a perceived change in physical characteristics of the device or the component of the device.", "For example, movement of a touch-sensitive surface (e.g., a touch-sensitive display or trackpad) is, optionally, interpreted by the user as a “down click” or “up click” of a physical actuator button.", "In some cases, a user will feel a tactile sensation such as an “down click” or “up click” even when there is no movement of a physical actuator button associated with the touch-sensitive surface that is physically pressed (e.g., displaced) by the user's movements.", "As another example, movement of the touch-sensitive surface is, optionally, interpreted or sensed by the user as “roughness” of the touch-sensitive surface, even when there is no change in smoothness of the touch-sensitive surface.", "While such interpretations of touch by a user will be subject to the individualized sensory perceptions of the user, there are many sensory perceptions of touch that are common to a large majority of users.", "Thus, when a tactile output is described as corresponding to a particular sensory perception of a user (e.g., an “up click,” a “down click,” “roughness”), unless otherwise stated, the generated tactile output corresponds to physical displacement of the device or a component thereof that will generate the described sensory perception for a typical (or average) user.", "It should be appreciated that device 100 is only one example of a portable multifunction device, and that device 100 optionally has more or fewer components than shown, optionally combines two or more components, or optionally has a different configuration or arrangement of the components.", "The various components shown in FIG.", "1A are implemented in hardware, software, or a combination of both hardware and software, including one or more signal processing and/or application specific integrated circuits.", "Memory 102 optionally includes high-speed random access memory and optionally also includes non-volatile memory, such as one or more magnetic disk storage devices, flash memory devices, or other non-volatile solid-state memory devices.", "Access to memory 102 by other components of device 100, such as CPU 120 and the peripherals interface 118, is, optionally, controlled by memory controller 122.Peripherals interface 118 can be used to couple input and output peripherals of the device to CPU 120 and memory 102.The one or more processors 120 run or execute various software programs and/or sets of instructions stored in memory 102 to perform various functions for device 100 and to process data.", "In some embodiments, peripherals interface 118, CPU 120, and memory controller 122 are, optionally, implemented on a single chip, such as chip 104.In some other embodiments, they are, optionally, implemented on separate chips.", "RF (radio frequency) circuitry 108 receives and sends RF signals, also called electromagnetic signals.", "RF circuitry 108 converts electrical signals to/from electromagnetic signals and communicates with communications networks and other communications devices via the electromagnetic signals.", "RF circuitry 108 optionally includes well-known circuitry for performing these functions, including but not limited to an antenna system, an RF transceiver, one or more amplifiers, a tuner, one or more oscillators, a digital signal processor, a CODEC chipset, a subscriber identity module (SIM) card, memory, and so forth.", "RF circuitry 108 optionally communicates with networks, such as the Internet, also referred to as the World Wide Web (WWW), an intranet and/or a wireless network, such as a cellular telephone network, a wireless local area network (LAN) and/or a metropolitan area network (MAN), and other devices by wireless communication.", "The wireless communication optionally uses any of a plurality of communications standards, protocols and technologies, including but not limited to Global System for Mobile Communications (GSM), Enhanced Data GSM Environment (EDGE), high-speed downlink packet access (HSDPA), high-speed uplink packet access (HSDPA), Evolution, Data-Only (EV-DO), HSPA, HSPA+, Dual-Cell HSPA (DC-HSPDA), long term evolution (LTE), near field communication (NEC), wideband code division multiple access (W-CDMA), code division multiple access (CDMA), time division multiple access (TDMA), Bluetooth, Wireless Fidelity (Wi-Fi) (e.g., IEEE 802.11a, IEEE 802.11b, IEEE 802.11g and/or IEEE 802.11n), voice over Internet Protocol (VoIP), Wi-MAX, a protocol for e-mail (e.g., Internet message access protocol (IMAP) and/or post office protocol (POP)), instant messaging (e.g., extensible messaging and presence protocol (XMPP), Session Initiation Protocol for Instant Messaging and Presence Leveraging Extensions (SIMPLE), Instant Messaging and Presence Service (IMPS)), and/or Short Message Service (SMS), or any other suitable communication protocol, including communication protocols not yet developed as of the filing date of this document.", "Audio circuitry 110, speaker 111, and microphone 113 provide an audio interface between a user and device 100.Audio circuitry 110 receives audio data from peripherals interface 118, converts the audio data to an electrical signal, and transmits the electrical signal to speaker 111.Speaker 111 converts the electrical signal to human-audible sound waves.", "Audio circuitry 110 also receives electrical signals converted by microphone 113 from sound waves.", "Audio circuitry 110 converts the electrical signal to audio data and transmits the audio data to peripherals interface 118 for processing.", "Audio data is, optionally, retrieved from and/or transmitted to memory 102 and/or RF circuitry 108 by peripherals interface 118.In some embodiments, audio circuitry 110 also includes a headset jack (e.g., 212, FIG.", "2).", "The headset jack provides an interface between audio circuitry 110 and removable audio input/output peripherals, such as output-only headphones or a headset with both output (e.g., a headphone for one or both ears) and input (e.g., a microphone).", "I/O subsystem 106 couples input/output peripherals on device 100, such as touch screen 112 and other input control devices 116, to peripherals interface 118.I/O subsystem 106 optionally includes display controller 156, optical sensor controller 158, intensity sensor controller 159, haptic feedback controller 161 and one or more input controllers 160 for other input or control devices.", "The one or more input controllers 160 receive/send electrical signals from/to other input or control devices 116.The other input control devices 116 optionally include physical buttons (e.g., push buttons, rocker buttons, etc.", "), dials, slider switches, joysticks, click wheels, and so forth.", "In some alternate embodiments, input controller(s) 160 are, optionally, coupled to any (or none) of the following: a keyboard, infrared port, USB port, and a pointer device such as a mouse.", "The one or more buttons (e.g., 208, FIG.", "2) optionally include an up/down button for volume control of speaker 111 and/or microphone 113.The one or more buttons optionally include a push button (e.g., 206, FIG.", "2).", "Touch-sensitive display 112 provides an input interface and an output interface between the device and a user.", "Display controller 156 receives and/or sends electrical signals from/to touch screen 112.Touch screen 112 displays visual output to the user.", "The visual output optionally includes graphics, text, icons, video, and any combination thereof (collectively termed “graphics”).", "In some embodiments, some or all of the visual output corresponds to user-interface objects.", "Touch screen 112 has a touch-sensitive surface, sensor or set of sensors that accepts input from the user based on haptic and/or tactile contact.", "Touch screen 112 and display controller 156 (along with any associated modules and/or sets of instructions in memory 102) detect contact (and any movement or breaking of the contact) on touch screen 112 and converts the detected contact into interaction with user-interface objects (e.g., one or more soft keys, icons, web pages or images) that are displayed on touch screen 112.In an exemplary embodiment, a point of contact between touch screen 112 and the user corresponds to a finger of the user.", "Touch screen 112 optionally uses LCD (liquid crystal display) technology, LPD (light emitting polymer display) technology, or LED (light emitting diode) technology, although other display technologies are used in other embodiments.", "Touch screen 112 and display controller 156 optionally detect contact and any movement or breaking thereof using any of a plurality of touch sensing technologies now known or later developed, including but not limited to capacitive, resistive, infrared, and surface acoustic wave technologies, as well as other proximity sensor arrays or other elements for determining one or more points of contact with touch screen 112.In an exemplary embodiment, projected mutual capacitance sensing technology is used, such as that found in the iPhone®, iPod Touch®, and iPad® from Apple Inc. of Cupertino, Calif. Touch screen 112 optionally has a video resolution in excess of 100 dpi.", "In some embodiments, the touch screen has a video resolution of approximately 160 dpi.", "The user optionally makes contact with touch screen 112 using any suitable object or appendage, such as a stylus, a finger, and so forth.", "In some embodiments, the user interface is designed to work primarily with finger-based contacts and gestures, which can be less precise than stylus-based input due to the larger area of contact of a finger on the touch screen.", "In some embodiments, the device translates the rough finger-based input into a precise pointer/cursor position or command for performing the actions desired by the user.", "In some embodiments, in addition to the touch screen, device 100 optionally includes a touchpad (not shown) for activating or deactivating particular functions.", "In some embodiments, the touchpad is a touch-sensitive area of the device that, unlike the touch screen, does not display visual output.", "The touchpad is, optionally, a touch-sensitive surface that is separate from touch screen 112 or an extension of the touch-sensitive surface formed by the touch screen.", "Device 100 also includes power system 162 for powering the various components.", "Power system 162 optionally includes a power management system, one or more power sources (e.g., battery, alternating current (AC)), a recharging system, a power failure detection circuit, a power converter or inverter, a power status indicator (e.g., a light-emitting diode (LED)) and any other components associated with the generation, management and distribution of power in portable devices.", "Device 100 optionally also includes one or more optical sensors 164.Figure IA shows an optical sensor coupled to optical sensor controller 158 in I/O subsystem 106.Optical sensor 164 optionally includes charge-coupled device (CCD) or complementary metal-oxide semiconductor (CMOS) phototransistors.", "Optical sensor 164 receives light from the environment, projected through one or more lens, and converts the light to data representing an image.", "In conjunction with imaging module 143 (also called a camera module), optical sensor 164 optionally captures still images or video.", "In some embodiments, an optical sensor is located on the back of device 100, opposite touch screen display 112 on the front of the device, so that the touch screen display is enabled for use as a viewfinder for still and/or video image acquisition.", "In some embodiments, another optical sensor is located on the front of the device so that the user's image is, optionally, obtained for videoconferencing while the user views the other video conference participants on the touch screen display.", "Device 100 optionally also includes one or more contact intensity sensors 165.FIG.", "1A shows a contact intensity sensor coupled to intensity sensor controller 159 in I/O subsystem 106.Contact intensity sensor 165 optionally includes one or more piezoresistive strain gauges, capacitive force sensors, electric force sensors, piezoelectric force sensors, optical force sensors, capacitive touch-sensitive surfaces, or other intensity sensors (e.g., sensors used to measure the force (or pressure) of a contact on a touch-sensitive surface).", "Contact intensity sensor 165 receives contact intensity information (e.g., pressure information or a proxy for pressure information) from the environment.", "In some embodiments, at least one contact intensity sensor is collocated with, or proximate to, a touch-sensitive surface (e.g., touch-sensitive display system 112).", "In some embodiments, at least one contact intensity sensor is located on the back of device 100, opposite touch screen display 112 which is located on the front of device 100.Device 100 optionally also includes one or more proximity sensors 166.FIG.", "1A shows proximity sensor 166 coupled to peripherals interface 118.Alternately, proximity sensor 166 is coupled to input controller 160 in I/O subsystem 106.In some embodiments, the proximity sensor turns off and disables touch screen 112 when the multifunction device is placed near the user's ear (e.g., when the user is making a phone call).", "Device 100 optionally also includes one or more tactile output generators 167.FIG.", "1A shows a tactile output generator coupled to haptic feedback controller 161 in I/O subsystem 106.Tactile output generator 167 optionally includes one or more electroacoustic devices such as speakers or other audio components and/or electromechanical devices that convert energy into linear motion such as a motor, solenoid, electroactive polymer, piezoelectric actuator, electrostatic actuator, or other tactile output generating component (e.g., a component that converts electrical signals into tactile outputs on the device).", "Contact intensity sensor 165 receives tactile feedback generation instructions from haptic feedback module 133 and generates tactile outputs on device 100 that are capable of being sensed by a user of device 100.In some embodiments, at least one tactile output generator is collocated with, or proximate to, a touch-sensitive surface (e.g., touch-sensitive display system 112) and, optionally, generates a tactile output by moving the touch-sensitive surface vertically (e.g., in/out of a surface of device 100) or laterally (e.g., back and forth in the same plane as a surface of device 100).", "In some embodiments, at least one tactile output generator sensor is located on the back of device 100, opposite touch screen display 112 which is located on the front of device 100.Device 100 optionally also includes one or more accelerometers 168.FIG.", "1A shows accelerometer 168 coupled to peripherals interface 118.Alternately, accelerometer 168 is, optionally, coupled to an input controller 160 in I/O subsystem 106.In some embodiments, information is displayed on the touch screen display in a portrait view or a landscape view based on an analysis of data received from the one or more accelerometers.", "Device 100 optionally includes, in addition to accelerometer(s) 168, a magnetometer (not shown) and a GPS (or GLONASS or other global navigation system) receiver (not shown) for obtaining information concerning the location and orientation (e.g., portrait or landscape) of device 100.In some embodiments, device 100 also includes (or is in communication with) one or more fingerprint sensors 169.FIG.", "1A shows fingerprint sensor 169 coupled to peripherals interface 118.Alternately, fingerprint sensors 169 are, optionally, coupled to an input controller 160 in I/O subsystem 106.However, in one common embodiment, fingerprint identification operations are performed using secured dedicated computing hardware (e.g., one or more processors, memory and/or communications busses) that has additional security features so as to enhance security of the fingerprint information determined by the fingerprint sensors.", "As used herein, a fingerprint sensor is a sensor that is capable of distinguishing fingerprint features (sometimes called “minutia features”) of the ridges and valleys of skin such as those found on the fingers and toes of humans.", "A fingerprint sensor can use any of a variety of techniques to distinguish the fingerprint features, including but not limited to: optical fingerprint imaging, ultrasonic fingerprint imaging, active capacitance fingerprint imaging and passive capacitance fingerprint imaging.", "In addition to distinguishing fingerprint features in fingerprints, in some embodiments, fingerprint sensor 169 is capable of tracking movement of fingerprint features over time and thereby determining/characterizing movement of the fingerprint over time on the fingerprint sensor.", "While the fingerprint sensor (e.g., Fingerprint Sensor 169) in FIG.", "1A is shown as being separate from the touch-sensitive surface (e.g., Touch-Sensitive Display System 112), it should be understood that in some implementations, the touch-sensitive surface (e.g., Touch-Sensitive Display System 112) has a spatial resolution that is high enough to detect fingerprint features formed by individual fingerprint ridges and is used as a fingerprint sensor instead of, or in addition to, a separate fingerprint sensor (e.g., Fingerprint Sensor 169).", "In some embodiments, device 100 includes a set of one or more orientation sensors that are used to determine an orientation of a finger or hand on or proximate to the device (e.g., an orientation of a finger that is over fingerprint sensor 169).", "Additionally, in some embodiments, the set of one or more orientation sensors are used in addition to or instead of a fingerprint sensor to detect rotation of a contact that is interacting with the device (e.g., in one or more of the methods described below, instead of using a fingerprint sensor to detect rotation of a fingerprint/contact, the set of one or more orientation sensors is used to detect rotation of the contact that includes the fingerprint, with or without detecting features of the fingerprint).", "In some embodiments, features of fingerprints and comparisons between features of detected fingerprints and features of stored fingerprints are performed by secured dedicated computing hardware (e.g., one or more processors, memory and/or communications busses) that are separate from processors 120, so as to improve security of the fingerprint data generated, stored and processed by fingerprint sensor 169.In some embodiments, features of fingerprints and comparisons between features of detected fingerprints and features of enrolled fingerprints are performed by processors 120 using fingerprint analysis module 131.In some embodiments, during an enrollment process, the device (e.g., fingerprint analysis module 131 or a separate secure module 146 in communication with fingerprint sensor(s) 169) collects biometric information about one or more fingerprints of the user (e.g., identifying relative location of a plurality of minutia points in a fingerprint of the user).", "After the enrollment process has been completed the biometric information is stored at the device (e.g., in secure fingerprint module 146) for later use in authenticating detected fingerprints.", "In some embodiments, the biometric information that is stored at the device excludes images of the fingerprints and also excludes information from which images of the fingerprints could be reconstructed so that images of the fingerprints are not inadvertently made available if the security of the device is compromised.", "In some embodiments, during an authentication process, the device (e.g., fingerprint analysis module 131 or a separate secure module 146 in communication with fingerprint sensor(s) 169) determines whether a finger input detected by the fingerprint sensor includes a fingerprint that matches a previously enrolled fingerprint by collecting biometric information about a fingerprint detected on the fingerprint sensor (e.g., identifying relative locations of a plurality of minutia points in the fingerprint detected on the fingerprint sensor) and comparing the biometric information that corresponds to the detected fingerprint to biometric information that corresponds to the enrolled fingerprints(s).", "In some embodiments, comparing the biometric information that corresponds to the detected fingerprint to biometric information that corresponds to the enrolled fingerprints(s) includes comparing a type and location of minutia points in the biometric information that corresponds to the detected fingerprint to a type and location of minutia points in the biometric information that corresponds to the enrolled fingerprints.", "However the determination as to whether or not a finger input includes a fingerprint that matches a previously enrolled fingerprint that is enrolled with the device is, optionally, performed using any of a number of well known fingerprint authentication techniques for determining whether a detected fingerprint matches an enrolled fingerprint.", "In some embodiments, the software components stored in memory 102 include operating system 126, communication module (or set of instructions), contact/motion module (or set of instructions) 130, fingerprint analysis module 131, graphics module (or set of instructions) 132, text input module (or set of instructions) 134, Global Positioning System (GPS) module (or set of instructions) 135, and applications (or sets of instructions) 136.Furthermore, in some embodiments memory 102 stores device/global internal state 157, as shown in FIGS.", "1A and 3.Device/global internal state 157 includes one or more of: active application state, indicating which applications, if any, are currently active; display state, indicating what applications, views or other information occupy various regions of touch screen display 112; sensor state, including information obtained from the device's various sensors and input control devices 116; and location information concerning the device's location and/or attitude.", "In some embodiments credential information is stored as secure credential information 145.Secure credential information, optionally, includes credentials for user accounts (e.g., user names and passwords, billing information, address information).", "In some embodiments, the credential information for one or more different applications is stored in a secure central location on the device, so that the credential information is accessible to different applications.", "In some embodiments, credential information that is associated with a particular application (e.g., a user name and password or billing information that has been entered into the particular application) is stored with the particular application (e.g., a user name and password for authorizing purchases in a store application are stored with the store application for ease of access by the store application).", "In some embodiments other security information (e.g., decryption keys for decrypting encrypted content stored at the device) is stored with secure credential information 145 or at another secure location on the device.", "Operating system 126 (e.g., Darwin, RTXC, LINUX, UNIX, OS X, WINDOWS, or an embedded operating system such as VxWorks) includes various software components and/or drivers for controlling and managing general system tasks (e.g., memory management, storage device control, power management, etc.)", "and facilitates communication between various hardware and software components.", "Communication module 128 facilitates communication with other devices over one or more external ports 124 and also includes various software components for handling data received by RE circuitry 108 and/or external port 124.External port 124 (e.g., Universal Serial Bus (USB), FIREWIRE, etc.)", "is adapted for coupling directly to other devices or indirectly over a network (e.g., the Internet, wireless LAN, etc.).", "In some embodiments, the external port is a multi-pin (e.g., 30-pin) connector that is the same as, or similar to and/or compatible with the 30-pin connector used on iPod (trademark of Apple Inc.) devices.", "Contact/motion module 130 optionally detects contact with touch screen 112 (in conjunction with display controller 156) and other touch sensitive devices (e.g., a touchpad or physical click wheel).", "Contact/motion module 130 includes various software components for performing various operations related to detection of contact, such as determining if contact has occurred (e.g., detecting a finger-down event), determining an intensity of the contact (e.g., the force or pressure of the contact or a substitute for the force or pressure of the contact), determining if there is movement of the contact and tracking the movement across the touch-sensitive surface (e.g., detecting one or more finger-dragging events), and determining if the contact has ceased (e.g., detecting a finger-up event or a break in contact).", "Contact/motion module 130 receives contact data from the touch-sensitive surface.", "Determining movement of the point of contact, which is represented by a series of contact data, optionally includes determining speed (magnitude), velocity (magnitude and direction), and/or an acceleration (a change in magnitude and/or direction) of the point of contact.", "These operations are, optionally, applied to single contacts (e.g., one finger contacts) or to multiple simultaneous contacts (e.g., “multitouch”/multiple finger contacts).", "In some embodiments, contact/motion module 130 and display controller 156 detect contact on a touchpad.", "In some embodiments, contact/motion module 130 uses a set of one or more intensity thresholds to determine whether an operation has been performed by a user (e.g., to determine whether a user has “clicked” on an icon).", "In some embodiments at least a subset of the intensity thresholds are determined in accordance with software parameters (e.g., the intensity thresholds are not determined by the activation thresholds of particular physical actuators and can be adjusted without changing the physical hardware of device 100).", "For example, a mouse “click” threshold of a trackpad or touch screen display can be set to any of a large range of predefined thresholds values without changing the trackpad or touch screen display hardware.", "Additionally, in some implementations a user of the device is provided with software settings for adjusting one or more of the set of intensity thresholds (e.g., by adjusting individual intensity thresholds and/or by adjusting a plurality of intensity thresholds at once with a system-level click “intensity” parameter).", "Contact/motion module 130 optionally detects a gesture input by a user.", "Different gestures on the touch-sensitive surface have different contact patterns (e.g., different motions, timings, and/or intensities of detected contacts).", "Thus, a gesture is, optionally, detected by detecting a particular contact pattern.", "For example, detecting a finger tap gesture includes detecting a finger-down event followed by detecting a finger-up (lift off) event at the same position (or substantially the same position) as the finger-down event (e.g., at the position of an icon).", "As another example, detecting a finger swipe gesture on the touch-sensitive surface includes detecting a finger-down event followed by detecting one or more finger-dragging events, and subsequently followed by detecting a finger-up (lift off) event.", "Fingerprint analysis module 131 optionally detects a finger input by a user on a fingerprint sensor and determines whether the finger input includes a fingerprint that corresponds to a previously enrolled fingerprint that is enrolled with the device and/or detects movement of the fingerprint that corresponds to a finger gesture.", "In some embodiments, the enrollment of fingerprints and the comparison between detected fingerprints and enrolled fingerprints is performed at a secure fingerprint analysis module 146 that is in communication with fingerprint sensor(s) 169 and secure fingerprint analysis module 146 provides fingerprint analysis module 131 with information indicating whether or not the detected fingerprint matches a previously enrolled fingerprint without providing biometric information about the detected fingerprint or the enrolled fingerprint to fingerprint analysis module 131 (e.g., so as to maintain the security of biometric information about detected and enrolled fingerprints).", "In some embodiments, information about movement of the fingerprint during the finger input and times of finger-up or finger-down events are also provided to fingerprint analysis module 131 by secure fingerprint analysis module 146.In some embodiments, the information about the finger input is used by fingerprint analysis module 131 to respond to the finger inputs (e.g., by unlocking the device, unlocking a function of the device, displaying previously redacted information, or performing an operation based on the movement of a fingerprint on the fingerprint sensor).", "Graphics module 132 includes various known software components for rendering and displaying graphics on touch screen 112 or other display, including components for changing the visual impact (e.g., brightness, transparency, saturation, contrast or other visual property) of graphics that are displayed.", "As used herein, the term “graphics” includes any object that can be displayed to a user, including without limitation text, web pages, icons (such as user-interface objects including soft keys), digital images, videos, animations and the like.", "In some embodiments, graphics module 132 stores data representing graphics to be used.", "Each graphic is, optionally, assigned a corresponding code.", "Graphics module 132 receives, from applications etc., one or more codes specifying graphics to be displayed along with, if necessary, coordinate data and other graphic property data, and then generates screen image data to output to display controller 156.Haptic feedback module 133 includes various software components for generating instructions used by tactile output generator(s) 167 to produce tactile outputs at one or more locations on device 100 in response to user interactions with device 100.Text input module 134, which is, optionally, a component of graphics module 132, provides soft keyboards for entering text in various applications (e.g., contacts 137, e-mail 140, IM 141, browser 147, and any other application that needs text input).", "GPS module 135 determines the location of the device and provides this information for use in various applications (e.g., to telephone 138 for use in location-based dialing, to camera 143 as picture/video metadata, and to applications that provide location-based services such as weather widgets, local yellow page widgets, and map/navigation widgets).", "Applications 136 optionally include the following modules (or sets of instructions), or a subset or superset thereof: contacts module 137 (sometimes called an address book or contact list); telephone module 138; video conferencing module 139; e-mail client module 140; instant messaging (IM) module 141; workout support module 142; camera module 143 for still and/or video images; image management module 144; browser module 147; calendar module 148; widget modules 149, which optionally include one or more of: weather widget 149-1, stocks widget 149-2, calculator widget 149-3, alarm clock widget 149-4, dictionary widget 149-5, and other widgets obtained by the user, as well as user-created widgets 149-6; widget creator module 150 for making user-created widgets 149-6; search module 151; video and music player module 152, which is, optionally, made up of a video player module and a music player module; notes module 153; map module 154; and/or online video module 155.Examples of other applications 136 that are, optionally, stored in memory 102 include other word processing applications, other image editing applications, drawing applications, presentation applications, JAVA-enabled applications, encryption, digital rights management, voice recognition, and voice replication.", "In conjunction with touch screen 112, display controller 156, contact module 130, graphics module 132, and text input module 134, contacts module 137 are, optionally, used to manage an address book or contact list (e.g., stored in application internal state 192 of contacts module 137 in memory 102 or memory 370), including: adding name(s) to the address book; deleting name(s) from the address book; associating telephone number(s), e-mail address(es), physical address(es) or other information with a name; associating an image with a name; categorizing and sorting names; providing telephone numbers or e-mail addresses to initiate and/or facilitate communications by telephone 138, video conference 139, e-mail 140, or IM 141; and so forth.", "In conjunction with RF circuitry 108, audio circuitry 110, speaker 111, microphone 113, touch screen 112, display controller 156, contact module 130, graphics module 132, and text input module 134, telephone module 138 are, optionally, used to enter a sequence of characters corresponding to a telephone number, access one or more telephone numbers in address book 137, modify a telephone number that has been entered, dial a respective telephone number, conduct a conversation and disconnect or hang up when the conversation is completed.", "As noted above, the wireless communication optionally uses any of a plurality of communications standards, protocols and technologies.", "In conjunction with RF circuitry 108, audio circuitry 110, speaker 111, microphone 113, touch screen 112, display controller 156, optical sensor 164, optical sensor controller 158, contact module 130, graphics module 132, text input module 134, contact list 137, and telephone module 138, videoconferencing module 139 includes executable instructions to initiate, conduct, and terminate a video conference between a user and one or more other participants in accordance with user instructions.", "In conjunction with RF circuitry 108, touch screen 112, display controller 156, contact module 130, graphics module 132, and text input module 134, e-mail client module 140 includes executable instructions to create, send, receive, and manage e-mail in response to user instructions.", "In conjunction with image management module 144, e-mail client module 140 makes it very easy to create and send e-mails with still or video images taken with camera module 143.In conjunction with RF circuitry 108, touch screen 112, display controller 156, contact module 130, graphics module 132, and text input module 134, the instant messaging module 141 includes executable instructions to enter a sequence of characters corresponding to an instant message, to modify previously entered characters, to transmit a respective instant message (for example, using a Short Message Service (SMS) or Multimedia Message Service (MMS) protocol for telephony-based instant messages or using XMPP, SIMPLE, or IMPS for Internet-based instant messages), to receive instant messages and to view received instant messages.", "In some embodiments, transmitted and/or received instant messages optionally include graphics, photos, audio files, video files and/or other attachments as are supported in a MMS and/or an Enhanced Messaging Service (EMS).", "As used herein, “instant messaging” refers to both telephony-based messages (e.g., messages sent using SMS or MMS) and Internet-based messages (e.g., messages sent using XMPP, SIMPLE, or IMPS).", "In conjunction with RF circuitry 108, touch screen 112, display controller 156, contact module 130, graphics module 132, text input module 134, GPS module 135, map module 154, and music player module 146, workout support module 142 includes executable instructions to create workouts (e.g., with time, distance, and/or calorie burning goals); communicate with workout sensors (sports devices); receive workout sensor data; calibrate sensors used to monitor a workout; select and play music for a workout; and display, store and transmit workout data.", "In conjunction with touch screen 112, display controller 156, optical sensor(s) 164, optical sensor controller 158, contact module 130, graphics module 132, and image management module 144, camera module 143 includes executable instructions to capture still images or video (including a video stream) and store them into memory 102, modify characteristics of a still image or video, or delete a still image or video from memory 102.In conjunction with touch screen 112, display controller 156, contact module 130, graphics module 132, text input module 134, and camera module 143, image management module 144 includes executable instructions to arrange, modify (e.g., edit), or otherwise manipulate, label, delete, present (e.g., in a digital slide show or album), and store still and/or video images.", "In conjunction with RF circuitry 108, touch screen 112, display system controller 156, contact module 130, graphics module 132, and text input module 134, browser module 147 includes executable instructions to browse the Internet in accordance with user instructions, including searching, linking to, receiving, and displaying web pages or portions thereof, as well as attachments and other files linked to web pages.", "In conjunction with RF circuitry 108, touch screen 112, display system controller 156, contact module 130, graphics module 132, text input module 134, e-mail client module 140, and browser module 147, calendar module 148 includes executable instructions to create, display, modify, and store calendars and data associated with calendars (e.g., calendar entries, to do lists, etc.)", "in accordance with user instructions.", "In conjunction with RF circuitry 108, touch screen 112, display system controller 156, contact module 130, graphics module 132, text input module 134, and browser module 147, widget modules 149 are mini-applications that are, optionally, downloaded and used by a user (e.g., weather widget 149-1, stocks widget 149-2, calculator widget 149-3, alarm clock widget 149-4, and dictionary widget 149-5) or created by the user (e.g., user-created widget 149-6).", "In some embodiments, a widget includes an HTML (Hypertext Markup Language) file, a CSS (Cascading Style Sheets) file, and a JavaScript file.", "In some embodiments, a widget includes an XML (Extensible Markup Language) file and a JavaScript file (e.g., Yahoo!", "Widgets).", "In conjunction with RF circuitry 108, touch screen 112, display system controller 156, contact module 130, graphics module 132, text input module 134, and browser module 147, the widget creator module 150 are, optionally, used by a user to create widgets (e.g., turning a user-specified portion of a web page into a widget).", "In conjunction with touch screen 112, display system controller 156, contact module 130, graphics module 132, and text input module 134, search module 151 includes executable instructions to search for text, music, sound, image, video, and/or other files in memory 102 that match one or more search criteria (e.g., one or more user-specified search terms) in accordance with user instructions.", "In conjunction with touch screen 112, display system controller 156, contact module 130, graphics module 132, audio circuitry 110, speaker 111, RF circuitry 108, and browser module 147, video and music player module 152 includes executable instructions that allow the user to download and play back recorded music and other sound files stored in one or more file formats, such as MP3 or AAC files, and executable instructions to display, present or otherwise play back videos (e.g., on touch screen 112 or on an external, connected display via external port 124).", "In some embodiments, device 100 optionally includes the functionality of an MP3 player, such as an iPod (trademark of Apple Inc.).", "In conjunction with touch screen 112, display controller 156, contact module 130, graphics module 132, and text input module 134, notes module 153 includes executable instructions to create and manage notes, to do lists, and the like in accordance with user instructions.", "In conjunction with RF circuitry 108, touch screen 112, display system controller 156, contact module 130, graphics module 132, text input module 134, GPS module 135, and browser module 147, map module 154 are, optionally, used to receive, display, modify, and store maps and data associated with maps (e.g., driving directions; data on stores and other points of interest at or near a particular location; and other location-based data) in accordance with user instructions.", "In conjunction with touch screen 112, display system controller 156, contact module 130, graphics module 132, audio circuitry 110, speaker 111, RF circuitry 108, text input module 134, e-mail client module 140, and browser module 147, online video module 155 includes instructions that allow the user to access, browse, receive (e.g., by streaming and/or download), play back (e.g., on the touch screen or on an external, connected display via external port 124), send an e-mail with a link to a particular online video, and otherwise manage online videos in one or more file formats, such as H.264.In some embodiments, instant messaging module 141, rather than e-mail client module 140, is used to send a link to a particular online video.", "Each of the above identified modules and applications correspond to a set of executable instructions for performing one or more functions described above and the methods described in this application (e.g., the computer-implemented methods and other information processing methods described herein).", "These modules (i.e., sets of instructions) need not be implemented as separate software programs, procedures or modules, and thus various subsets of these modules are, optionally, combined or otherwise re-arranged in various embodiments.", "In some embodiments, memory 102 optionally stores a subset of the modules and data structures identified above.", "Furthermore, memory 102 optionally stores additional modules and data structures not described above.", "In some embodiments, device 100 is a device where operation of a predefined set of functions on the device is performed exclusively through a touch screen and/or a touchpad.", "By using a touch screen and/or a touchpad as the primary input control device for operation of device 100, the number of physical input control devices (such as push buttons, dials, and the like) on device 100 is, optionally, reduced.", "The predefined set of functions that are performed exclusively through a touch screen and/or a touchpad optionally include navigation between user interfaces.", "In some embodiments, the touchpad, when touched by the user, navigates device 100 to a main, home, or root menu from any user interface that is displayed on device 100.In such embodiments, a “menu button” is implemented using a touchpad.", "In some other embodiments, the menu button is a physical push button or other physical input control device instead of a touchpad.", "FIG.", "1B is a block diagram illustrating exemplary components for event handling in accordance with some embodiments.", "In some embodiments, memory 102 (in FIG.", "1A) or 370 (FIG.", "3) includes event sorter 170 (e.g., in operating system 126) and a respective application 136-1 (e.g., any of the aforementioned applications 137-13, 155, 380-390).", "Event sorter 170 receives event information and determines the application 136-1 and application view 191 of application 136-1 to which to deliver the event information.", "Event sorter 170 includes event monitor 171 and event dispatcher module 174.In some embodiments, application 136-1 includes application internal state 192, which indicates the current application view(s) displayed on touch sensitive display 112 when the application is active or executing.", "In some embodiments, device/global internal state 157 is used by event sorter 170 to determine which application(s) is (are) currently active, and application internal state 192 is used by event sorter 170 to determine application views 191 to which to deliver event information.", "In some embodiments, application internal state 192 includes additional information, such as one or more of: resume information to be used when application 136-1 resumes execution, user interface state information that indicates information being displayed or that is ready for display by application 136-1, a state queue for enabling the user to go back to a prior state or view of application 136-1, and a redo/undo queue of previous actions taken by the user.", "Event monitor 171 receives event information from peripherals interface 118 or, optionally, fingerprint analysis module 131.Event information includes information about a sub-event (e.g., a user touch on touch-sensitive display 112, as part of a multi-touch gesture or a finger input on a fingerprint sensor 169).", "Peripherals interface 118 transmits information it receives from I/O subsystem 106 or a sensor, such as proximity sensor 166, accelerometer(s) 168, fingerprint sensor 169, and/or microphone 113 (through audio circuitry 110).", "Information that peripherals interface 118 receives from I/O subsystem 106 includes information from touch-sensitive display 112 or a touch-sensitive surface.", "In some embodiments, event monitor 171 sends requests to the peripherals interface 118 at predetermined intervals.", "In response, peripherals interface 118 transmits event information.", "In other embodiments, peripheral interface 118 transmits event information only when there is a significant event (e.g., receiving an input above a predetermined noise threshold and/or for more than a predetermined duration).", "In some embodiments, event sorter 170 also includes a hit view determination module 172 and/or an active event recognizer determination module 173.Hit view determination module 172 provides software procedures for determining where a sub-event has taken place within one or more views, when touch sensitive display 112 displays more than one view.", "Views are made up of controls and other elements that a user can see on the display.", "Another aspect of the user interface associated with an application is a set of views, sometimes herein called application views or user interface windows, in which information is displayed and touch-based gestures occur.", "The application views (of a respective application) in which a touch is detected optionally correspond to programmatic levels within a programmatic or view hierarchy of the application.", "For example, the lowest level view in which a touch is detected is, optionally, called the hit view, and the set of events that are recognized as proper inputs are, optionally, determined based, at least in part, on the hit view of the initial touch that begins a touch-based gesture.", "Hit view determination module 172 receives information related to sub-events of a touch-based gesture.", "When an application has multiple views organized in a hierarchy, hit view determination module 172 identifies a hit view as the lowest view in the hierarchy which should handle the sub-event.", "In most circumstances, the hit view is the lowest level view in which an initiating sub-event occurs (i.e., the first sub-event in the sequence of sub-events that form an event or potential event).", "Once the hit view is identified by the hit view determination module, the hit view typically receives all sub-events related to the same touch or input source for which it was identified as the hit view.", "Active event recognizer determination module 173 determines which view or views within a view hierarchy should receive a particular sequence of sub-events.", "In some embodiments, active event recognizer determination module 173 determines that only the hit view should receive a particular sequence of sub-events.", "In other embodiments, active event recognizer determination module 173 determines that all views that include the physical location of a sub-event are actively involved views, and therefore determines that all actively involved views should receive a particular sequence of sub-events.", "In other embodiments, even if touch sub-events were entirely confined to the area associated with one particular view, views higher in the hierarchy would still remain as actively involved views.", "Event dispatcher module 174 dispatches the event information to an event recognizer (e.g., event recognizer 180).", "In embodiments including active event recognizer determination module 173, event dispatcher module 174 delivers the event information to an event recognizer determined by active event recognizer determination module 173.In some embodiments, event dispatcher module 174 stores in an event queue the event information, which is retrieved by a respective event receiver module 182.In some embodiments, operating system 126 includes event sorter 170.Alternatively, application 136-1 includes event sorter 170.In yet other embodiments, event sorter 170 is a stand-alone module, or a part of another module stored in memory 102, such as contact/motion module 130.In some embodiments, application 136-1 includes a plurality of event handlers 190 and one or more application views 191, each of which includes instructions for handling touch events that occur within a respective view of the application's user interface.", "Each application view 191 of the application 136-1 includes one or more event recognizers 180.Typically, a respective application view 191 includes a plurality of event recognizers 180.In other embodiments, one or more of event recognizers 180 are part of a separate module, such as a user interface kit (not shown) or a higher level object from which application 136-1 inherits methods and other properties.", "In some embodiments, a respective event handler 190 includes one or more of: data updater 176, object updater 177, GUI updater 178, and/or event data 179 received from event sorter 170.Event handler 190 optionally utilizes or calls data updater 176, object updater 177 or GUI updater 178 to update the application internal state 192.Alternatively, one or more of the application views 191 includes one or more respective event handlers 190.Also, in some embodiments, one or more of data updater 176, object updater 177, and GUI updater 178 are included in a respective application view 191.A respective event recognizer 180 receives event information (e.g., event data 179) from event sorter 170, and identifies an event from the event information.", "Event recognizer 180 includes event receiver 182 and event comparator 184.In some embodiments, event recognizer 180 also includes at least a subset of: metadata 183, and event delivery instructions 188 (which optionally include sub-event delivery instructions).", "Event receiver 182 receives event information from event sorter 170.The event information includes information about a sub-event, for example, a touch or a touch movement, or a finger input or fingerprint movement.", "Depending on the sub-event, the event information also includes additional information, such as location of the sub-event.", "When the sub-event concerns motion of a touch, the event information optionally also includes speed and direction of the sub-event.", "In some embodiments, events include rotation of the device from one orientation to another (e.g., from a portrait orientation to a landscape orientation, or vice versa), and the event information includes corresponding information about the current orientation (also called device attitude) of the device.", "Event comparator 184 compares the event information to predefined event or sub-event definitions and, based on the comparison, determines an event or sub-event, or determines or updates the state of an event or sub-event.", "In some embodiments, event comparator 184 includes event definitions 186.Event definitions 186 contain definitions of events (e.g., predefined sequences of sub-events), for example, event 1 (187-1), event 2 (187-2), and others.", "In some embodiments, sub-events in an event 187 include, for example, touch begin, touch end, touch movement, touch cancellation, multiple touching, fingerprint begin, fingerprint end, fingerprint movement, fingerprint authenticate, and fingerprint authentication fail.", "In one example, the definition for event 1 (187-1) is a double tap on a displayed object.", "The double tap, for example, comprises a first touch (touch begin) on the displayed object for a predetermined phase, a first lift-off (touch end) for a predetermined phase, a second touch (touch begin) on the displayed object for a predetermined phase, and a second lift-off (touch end) for a predetermined phase.", "In another example, the definition for event 2 (187-2) is a dragging on a displayed object.", "The dragging, for example, comprises a touch (or contact) on the displayed object for a predetermined phase, a movement of the touch across touch-sensitive display 112, and lift-off of the touch (touch end).", "In some embodiments, the event also includes information for one or more associated event handlers 190.In some embodiments, event definition 187 includes a definition of an event for a respective user-interface object.", "In some embodiments, event comparator 184 performs a hit test to determine which user-interface object is associated with a sub-event.", "For example, in an application view in which three user-interface objects are displayed on touch-sensitive display 112, when a touch is detected on touch-sensitive display 112, event comparator 184 performs a hit test to determine which of the three user-interface objects is associated with the touch (sub-event).", "If each displayed object is associated with a respective event handler 190, the event comparator uses the result of the hit test to determine which event handler 190 should be activated.", "For example, event comparator 184 selects an event handler associated with the sub-event and the object triggering the hit test.", "In some embodiments, the definition for a respective event 187 also includes delayed actions that delay delivery of the event information until after it has been determined whether the sequence of sub-events does or does not correspond to the event recognizer's event type.", "When a respective event recognizer 180 determines that the series of sub-events do not match any of the events in event definitions 186, the respective event recognizer 180 enters an event impossible, event failed, or event ended state, after which it disregards subsequent sub-events of the touch-based gesture.", "In this situation, other event recognizers, if any, that remain active for the hit view continue to track and process sub-events of an ongoing touch-based gesture.", "In some embodiments, a respective event recognizer 180 includes metadata 183 with configurable properties, flags, and/or lists that indicate how the event delivery system should perform sub-event delivery to actively involved event recognizers.", "In some embodiments, metadata 183 includes configurable properties, flags, and/or lists that indicate how event recognizers interact, or are enabled to interact, with one another.", "In some embodiments, metadata 183 includes configurable properties, flags, and/or lists that indicate whether sub-events are delivered to varying levels in the view or programmatic hierarchy.", "In some embodiments, a respective event recognizer 180 activates event handler 190 associated with an event when one or more particular sub-events of an event are recognized.", "In some embodiments, a respective event recognizer 180 delivers event information associated with the event to event handler 190.Activating an event handler 190 is distinct from sending (and deferred sending) sub-events to a respective hit view.", "In some embodiments, event recognizer 180 throws a flag associated with the recognized event, and event handler 190 associated with the flag catches the flag and performs a predefined process.", "In some embodiments, event delivery instructions 188 include sub-event delivery instructions that deliver event information about a sub-event without activating an event handler.", "Instead, the sub-event delivery instructions deliver event information to event handlers associated with the series of sub-events or to actively involved views.", "Event handlers associated with the series of sub-events or with actively involved views receive the event information and perform a predetermined process.", "In some embodiments, data updater 176 creates and updates data used in application 136-1.For example, data updater 176 updates the telephone number used in contacts module 137, or stores a video file used in video player module 145.In some embodiments, object updater 177 creates and updates objects used in application 136-1.For example, object updater 176 creates a new user-interface object or updates the position of a user-interface object.", "GUI updater 178 updates the GUI.", "For example, GUI updater 178 prepares display information and sends it to graphics module 132 for display on a touch-sensitive display.", "In some embodiments, event handler(s) 190 includes or has access to data updater 176, object updater 177, and GUI updater 178.In some embodiments, data updater 176, object updater 177, and GUI updater 178 are included in a single module of a respective application 136-1 or application view 191.In other embodiments, they are included in two or more software modules.", "It shall be understood that the foregoing discussion regarding event handling of user touches on touch-sensitive displays also applies to other forms of user inputs to operate multifunction devices 100 with input-devices, not all of which are initiated on touch screens.", "For example, mouse movement and mouse button presses, optionally coordinated with single or multiple keyboard presses or holds; contact movements such as taps, drags, scrolls, etc., on touch-pads; pen stylus inputs; movement of the device; oral instructions; detected eye movements; biometric inputs; and/or any combination thereof are optionally utilized as inputs corresponding to sub-events which define an event to be recognized.", "FIG.", "2 illustrates a portable multifunction device 100 having a touch screen 112 in accordance with some embodiments.", "The touch screen optionally displays one or more graphics within user interface (UI) 200.In this embodiment, as well as others described below, a user is enabled to select one or more of the graphics by making a gesture on the graphics, for example, with one or more fingers 202 (not drawn to scale in the figure) or one or more styluses 203 (not drawn to scale in the figure).", "In some embodiments, selection of one or more graphics occurs when the user breaks contact with the one or more graphics.", "In some embodiments, the gesture optionally includes one or more taps, one or more swipes (from left to right, right to left, upward and/or downward) and/or a rolling of a finger (from right to left, left to right, upward and/or downward) that has made contact with device 100.In some implementations or circumstances, inadvertent contact with a graphic does not select the graphic.", "For example, a swipe gesture that sweeps over an application icon optionally does not select the corresponding application when the gesture corresponding to selection is a tap.", "Device 100 optionally also includes one or more physical buttons, such as “home” or menu button 204.As described previously, menu button 204 is, optionally, used to navigate to any application 136 in a set of applications that are, optionally executed on device 100.Alternatively, in some embodiments, the menu button is implemented as a soft key in a GUI displayed on touch screen 112.In some embodiments button 204 includes an integrated fingerprint sensor 169-1 for identifying a fingerprint that is interacting with button 204 and/or detecting movement of the fingerprint on button 204.Device also, optionally, includes one or more other fingerprint sensors 169-2 that are separate from button 204 and are used instead of or in conjunction with a fingerprint sensor 169-1 integrated into button 204 to identify a user interacting with the device and/or detect motion of the fingerprint.", "Additionally, one or more of the other fingerprint sensors 169-2 are optionally associated with a button (e.g., a pressure sensitive region that is activated by detecting an input with an intensity above an activation intensity threshold or a physical actuator that moves in response force applied by a user).", "In implementations where the touch-sensitive surface (e.g., Touch Screen 112) has a spatial resolution that is high enough to detect fingerprint features formed by individual fingerprint ridges, the touch-sensitive surface (e.g., Touch Screen 112) is optionally used as a fingerprint sensor instead of, or in addition to, a separate fingerprint sensor (e.g., Fingerprint Sensors 169-1 or 169-2).", "In some embodiments, device 100 includes a set of one or more orientation sensors that are used to determine an orientation of a hand on device 100.In one embodiment, device 100 includes touch screen 112, menu button 204, push button 206 for powering the device on/off and locking the device, volume adjustment button(s) 208, Subscriber Identity Module (SIM) card slot 210, head set jack 212, and docking/charging external port 124.Push button 206 is, optionally, used to turn the power on/off on the device by depressing the button and holding the button in the depressed state for a predefined time interval; to lock the device by depressing the button and releasing the button before the predefined time interval has elapsed; and/or to unlock the device or initiate an unlock process.", "In an alternative embodiment, device 100 also accepts verbal input for activation or deactivation of some functions through microphone 113.Device 100 also, optionally, includes one or more contact intensity sensors 165 for detecting intensity of contacts on touch screen 112 and/or one or more tactile output generators 167 for generating tactile outputs for a user of device 100.FIG.", "3 is a block diagram of an exemplary multifunction device with a display and a touch-sensitive surface in accordance with some embodiments.", "Device 300 need not be portable.", "In some embodiments, device 300 is a laptop computer, a desktop computer, a tablet computer, a multimedia player device, a navigation device, an educational device (such as a child's learning toy), a gaming system, or a control device (e.g., a home or industrial controller).", "Device 300 typically includes one or more processing units (CPU's) 310, one or more network or other communications interfaces 360, memory 370, and one or more communication buses 320 for interconnecting these components.", "Communication buses 320 optionally include circuitry (sometimes called a chipset) that interconnects and controls communications between system components.", "Device 300 includes input/output (I/O) interface 330 comprising display 340, which is typically a touch screen display.", "I/O interface 330 also optionally includes a keyboard and/or mouse (or other pointing device) 350 and touchpad 355, tactile output generator 357 for generating tactile outputs on device 300 (e.g., similar to tactile output generator(s) 167 described above with reference to FIG.", "1A), sensors 359 (e.g., optical, acceleration, proximity, touch-sensitive, and/or contact intensity sensors similar to contact intensity sensor(s) 165 described above with reference to FIG.", "1A, and/or fingerprint sensors similar to fingerprint sensor(s) 169 described above with reference to FIG.", "1A).", "Additionally, in implementations where the touch-sensitive surface (e.g., Touchpad 355) has a spatial resolution that is high enough to detect fingerprint features formed by individual fingerprint ridges, the touch-sensitive surface (e.g., Touchpad 355) is optionally used as a fingerprint sensor instead of, or in addition to, a separate fingerprint sensor (e.g., one of sensors 359).", "In some embodiments, device 300 includes a set of one or more orientation sensors that are used to determine an orientation of a finger or hand on or proximate to the device (e.g., an orientation of a finger that is over fingerprint sensor 169).", "Additionally, in some embodiments, the set of one or more orientation sensors are used in addition to or instead of a fingerprint sensor to detect rotation of a contact that is interacting with the device.", "For example, in one or more of the methods described below, instead of using a fingerprint sensor to detect rotation of a fingerprint/contact, the set of one or more orientation sensors is used to detect rotation of the contact that includes the fingerprint, with or without detecting features of the fingerprint.", "Memory 370 includes high-speed random access memory, such as DRAM, SRAM, DDR RAM or other random access solid state memory devices; and optionally includes non-volatile memory, such as one or more magnetic disk storage devices, optical disk storage devices, flash memory devices, or other non-volatile solid state storage devices.", "Memory 370 optionally includes one or more storage devices remotely located from CPU(s) 310.In some embodiments, memory 370 stores programs, modules, and data structures analogous to the programs, modules, and data structures stored in memory 102 of portable multifunction device 100 (FIG.", "1A), or a subset thereof.", "Furthermore, memory 370 optionally stores additional programs, modules, and data structures not present in memory 102 of portable multifunction device 100.For example, memory 370 of device 300 optionally stores drawing module 380, presentation module 382, word processing module 384, website creation module 386, disk authoring module 388, and/or spreadsheet module 390, while memory 102 of portable multifunction device 100 (FIG.", "1A) optionally does not store these modules.", "Each of the above identified elements in FIG.", "3 are, optionally, stored in one or more of the previously mentioned memory devices.", "Each of the above identified modules corresponds to a set of instructions for performing a function described above.", "The above identified modules or programs (i.e.", "sets of instructions) need not be implemented as separate software programs, procedures or modules, and thus various subsets of these modules are, optionally, combined or otherwise re-arranged in various embodiments.", "In some embodiments, memory 370 optionally stores a subset of the modules and data structures identified above.", "Furthermore, memory 370 optionally stores additional modules and data structures not described above.", "Attention is now directed towards embodiments of user interfaces (“UI”) that is, optionally, implemented on portable multifunction device 100.FIG.", "4A illustrates an exemplary user interface for a menu of applications on portable multifunction device 100 in accordance with some embodiments.", "Similar user interfaces are, optionally, implemented on device 300.In some embodiments, user interface 400 includes the following elements, or a subset or superset thereof: Signal strength indicator(s) 402 for wireless communication(s), such as cellular and Wi-Fi signals; Time 404; Bluetooth indicator 405; Battery status indicator 406; Tray 408 with icons for frequently used applications, such as: Icon 416 for telephone module 138, labeled “Phone,” which optionally includes an indicator 414 of the number of missed calls or voicemail messages; Icon 418 for e-mail client module 140, labeled “Mail,” which optionally includes an indicator 410 of the number of unread e-mails; Icon 420 for browser module 147, labeled “Browser;” and Icon 422 for video and music player module 152, also referred to as iPod (trademark of Apple Inc.) module 152, labeled “iPod;” and Icons for other applications, such as: Icon 424 for IM module 141, labeled “Text;” Icon 426 for calendar module 148, labeled “Calendar;” Icon 428 for image management module 144, labeled “Photos;” Icon 430 for camera module 143, labeled “Camera;” Icon 432 for online video module 155, labeled “Online Video” Icon 434 for stocks widget 149-2, labeled “Stocks;” Icon 436 for map module 154, labeled “Map;” Icon 438 for weather widget 149-1, labeled “Weather;” Icon 440 for alarm clock widget 149-4, labeled “Clock;” Icon 442 for workout support module 142, labeled “Workout Support;” Icon 444 for notes module 153, labeled “Notes;” and Icon 446 for a settings application or module, which provides access to settings for device 100 and its various applications 136.It should be noted that the icon labels illustrated in FIG.", "4A are merely exemplary.", "For example, icon 422 for video and music player module 152 are labeled “Music” or “Music Player.” Other labels are, optionally, used for various application icons.", "In some embodiments, a label for a respective application icon includes a name of an application corresponding to the respective application icon.", "In some embodiments, a label for a particular application icon is distinct from a name of an application corresponding to the particular application icon.", "FIG.", "4B illustrates an exemplary user interface on a device (e.g., device 300, FIG.", "3) with a touch-sensitive surface 451 (e.g., a tablet or touchpad 355, FIG.", "3) that is separate from the display 450 (e.g., touch screen display 112) with an integrated 359-1 (or separate 359-2) fingerprint sensor (e.g., one or more of sensors 359 that operates in an analogous manner to fingerprint sensor 169 in FIG.", "1A).", "Additionally, in implementations where the touch-sensitive surface 451 has a spatial resolution that is high enough to detect fingerprint features formed by individual fingerprint ridges, the touch-sensitive surface 451 is optionally used as a fingerprint sensor instead of, or in addition to, a distinct fingerprint sensor (e.g., integrated fingerprint sensor 359-1 or separate fingerprint sensor 359-2).", "Device 300 also, optionally, includes one or more contact intensity sensors (e.g., one or more of sensors 359-3) for detecting intensity of contacts on touch-sensitive surface 451 and/or one or more tactile output generators 357 for generating tactile outputs for a user of device 300.Although some of the examples which follow will be given with reference to inputs on touch screen display 112 (where the touch sensitive surface and the display are combined), in some embodiments, the device detects inputs on a touch-sensitive surface that is separate from the display, as shown in FIG.", "4B.", "In some embodiments the touch sensitive surface (e.g., 451 in FIG.", "4B) has a primary axis (e.g., 452 in FIG.", "4B) that corresponds to a primary axis (e.g., 453 in FIG.", "4B) on the display (e.g., 450).", "In accordance with these embodiments, the device detects contacts (e.g., 460 and 462 in FIG.", "4B) with the touch-sensitive surface 451 at locations that correspond to respective locations on the display (e.g., in FIG.", "4B, 460 corresponds to 468 and 462 corresponds to 470).", "In this way, user inputs (e.g., contacts 460 and 462, and movements thereof) detected by the device on the touch-sensitive surface (e.g., 451 in FIG.", "4B) are used by the device to manipulate the user interface on the display (e.g., 450 in FIG.", "4B) of the multifunction device when the touch-sensitive surface is separate from the display.", "It should be understood that similar methods are, optionally, used for other user interfaces described herein.", "Additionally, while the following examples are given primarily with reference to finger inputs (e.g., finger contacts, finger tap gestures, finger swipe gestures), it should be understood that, in some embodiments, one or more of the finger inputs are replaced with input from another input device (e.g., a mouse based input or stylus input).", "For example, a swipe gesture is, optionally, replaced with a mouse click (e.g., instead of a contact) followed by movement of the cursor along the path of the swipe (e.g., instead of movement of the contact).", "As another example, a tap gesture is, optionally, replaced with a mouse click while the cursor is located over the location of the tap gesture (e.g., instead of detection of the contact followed by ceasing to detect the contact).", "Similarly, when multiple user inputs are simultaneously detected, it should be understood that multiple computer mice are, optionally, used simultaneously, or a mouse and finger contacts are, optionally, used simultaneously.", "As used herein, the term “focus selector” refers to an input element that indicates a current part of a user interface with which a user is interacting.", "In some implementations that include a cursor or other location marker, the cursor acts as a “focus selector,” so that when an input (e.g., a press input) is detected on a touch-sensitive surface (e.g., touchpad 355 in FIG.", "3 or touch-sensitive surface 451 in FIG.", "4B) while the cursor is over a particular user interface element (e.g., a button, window, slider or other user interface element), the particular user interface element is adjusted in accordance with the detected input.", "In some implementations that include a touch-screen display (e.g., touch-sensitive display system 112 in FIG.", "1A or touch screen 112 in FIG.", "4A) that enables direct interaction with user interface elements on the touch-screen display, a detected contact on the touch-screen acts as a “focus selector,” so that when an input (e.g., a press input by the contact) is detected on the touch-screen display at a location of a particular user interface element (e.g., a button, window, slider or other user interface element), the particular user interface element is adjusted in accordance with the detected input.", "In some implementations focus is moved from one region of a user interface to another region of the user interface without corresponding movement of a cursor or movement of a contact on a touch-screen display (e.g., by using a tab key or arrow keys to move focus from one button to another button); in these implementations, the focus selector moves in accordance with movement of focus between different regions of the user interface.", "Without regard to the specific form taken by the focus selector, the focus selector is generally the user interface element (or contact on a touch-screen display) that is controlled by the user so as to communicate the user's intended interaction with the user interface (e.g., by indicating, to the device, the element of the user interface with which the user is intending to interact).", "For example, the location of a focus selector (e.g., a cursor, a contact or a selection box) over a respective button while a press input is detected on the touch-sensitive surface (e.g., a touchpad or touch screen) will indicate that the user is intending to activate the respective button (as opposed to other user interface elements shown on a display of the device).", "FIG.", "4C shows a schematic representation of a two hands with associated fingerprints LP (“left pinky” fingerprint), LR (“left ring” fingerprint), LM (“left middle” fingerprint), LI (“left index” fingerprint), LT (“left thumb” fingerprint), RT (“right thumb” fingerprint), RI (“right index” fingerprint), RM (“right middle” fingerprint), RR (“right ring” fingerprint), RP (“right pinky” fingerprint).", "These abbreviations will be used with reference to other figures showing examples of interactions with a fingerprint sensor.", "For some of the methods described herein, one or more fingerprints of a user are registered by collecting information about the fingerprint that would enable the fingerprint to be identified.", "These registered fingerprints or pre-registered fingerprints are also sometimes referred to as enrolled fingerprints.", "In many situations described below, fingerprints detected on a fingerprint sensor are compared against previously registered fingerprints (e.g., enrolled fingerprints).", "FIG.", "4D shows two different types of rotation of a fingerprint on a fingerprint sensor (e.g., fingerprint sensor 169 that is integrated into button 204).", "On the left side of FIG.", "4D, is an example of a fingerprint “revolving” around a fingerprint sensor, where a centroid of the fingerprint moves in a looping motion (e.g., a circular-type motion) around a center of the fingerprint sensor.", "On the right side of FIG.", "4D, is an example of a fingerprint “twisting” on a fingerprint sensor, where a primary axis of the fingerprint changes orientation relative to the fingerprint sensor.", "These terms (e.g., “revolving” and “twisting”) will be used to described different types of rotation of a fingerprint on a fingerprint sensor with reference to other figures showing examples of interactions with a fingerprint sensor.", "As shown in FIG.", "4D, in some embodiments, the fingerprint sensor is smaller than, or approximately the same size as, an average fingerprint.", "Thus, in some embodiments, the fingerprint sensor detects movement of the fingerprint (e.g., fingerprint gestures) by detecting movement of fingerprint features of the fingerprint instead of or in addition to detecting movement of edges of the fingerprint.", "In other words, in some implementations, the fingerprint sensor detects movement of the fingerprint not by determining movement of an outline of the fingerprint (e.g., a “contact”) but by detecting movement of ridges (or specific minutia points in the ridges) of the fingerprint over the fingerprint sensor.", "Without regard to whether the fingerprint sensor is larger or smaller than the fingerprint, detecting movement of a fingerprint (e.g., fingerprint gestures) based on movement of fingerprint features instead of, or in addition to, detecting movement of the fingerprint based on movement of an edge or outline of the fingerprint enables movement of the fingerprint to be tracked in much greater detail and provides the ability to track fingerprint movement even when a fingerprint is covering all or a large portion of the fingerprint sensor.", "User Interfaces and Associated Processes Enrolling Fingerprints with a Device Many electronic devices provide a method to unlock the device.", "For example, a user is required enter a passcode or personal identification number (PIN), perform a swipe gesture in a predefined pattern, or slide an affordance to unlock the device to access private user information and applications.", "However, with the increased penetration of e-commerce and mobile purchasing, greater security is required to unlock a device.", "The device described below improves on existing methods by enrolling a fingerprint of a respective finger with a device after collecting fingerprint information from a plurality of separate and distinct stationary finger gestures.", "In turn, the device performs restricted operations (e.g., unlocking the device or mobile purchasing) when a detected fingerprint matches an enrolled fingerprint.", "The device displays a fingerprint enrollment interface and detects on a fingerprint sensor a plurality of separate and distinct stationary finger gestures performed with a respective finger.", "The device collects fingerprint information from the plurality of separate and distinct stationary finger gestures performed with the respective finger.", "After collecting the fingerprint information, the device determines, based on fingerprint information collected for the respective finger, whether the fingerprint information that has been collected is sufficient to enroll a fingerprint of the respective finger with the device.", "In accordance with a determination that the fingerprint information that has been collected for the respective finger is sufficient to enroll the fingerprint of the respective finger, the device enrolls the fingerprint of the respective finger with the device.", "In accordance with a determination that the fingerprint information that has been collected for the respective finger is not sufficient to enroll the fingerprint of the respective finger, the device displays a message in the fingerprint enrollment interface prompting a user to perform one or more additional stationary finger gestures on the fingerprint sensor with the respective finger.", "In some embodiments, the device is an electronic device with a separate display (e.g., display 450) and a separate touch-sensitive surface (e.g., touch-sensitive surface 451).", "In some embodiments, the device is portable multifunction device 100, the display is touch screen 112, and the touch-sensitive surface includes tactile output generators 167 on the display (FIG.", "1A).", "The device described below with reference to 5A-5EE and 6A-6D includes one or more fingerprint sensors 169.In some embodiments, the one or more fingerprint sensors include one or more integrated fingerprint sensors 359-1 (FIG.", "4B) that are integrated in to the touch-sensitive surface (e.g.", "separate touch-sensitive surface 451 or touch sensitive display system 112).", "In some embodiments, the one or more fingerprint sensors include separate fingerprint sensors 359-2 (FIG.", "4B) that are separate from the touch-sensitive surface (e.g., separate touch-sensitive surface 451 or touch sensitive display system 112).", "Unless specified otherwise, a fingerprint sensor 169 described below is, optionally, either an integrated fingerprint sensor 359-1 or a separate fingerprint sensor 359-2, depending on the configuration of the hardware and software of the device that includes the fingerprint sensor 169.For convenience of explanation, the embodiments described with reference to FIGS.", "5A-5EE and 6A-6D will be discussed with reference to a device with a touch screen 112 and a separate fingerprint sensor 359-2, however analogous operations are, optionally, performed on a device with an integrated fingerprint sensor 359-1 in response to detecting the inputs described in FIGS.", "5A-5EE on the integrated fingerprint sensor 359-1 while displaying the user interfaces shown in FIGS.", "5A-5EE on the display 450.Additionally, analogous operations are, optionally, performed on a device with a display 450 and a separate touch-sensitive surface 451 instead of a touch screen 112 in response to detecting the contacts described in FIGS.", "5A-5EE on a fingerprint sensor 169 (e.g., an integrated fingerprint sensor 359-1 or a separate fingerprint sensor 359-2) and/or the separate touch-sensitive surface 451 while displaying the user interfaces shown in FIGS.", "5A-5EE on the display 450; in such embodiments, the contacts shown in FIGS.", "5A-5EE optionally represent both a focus selector that corresponds to a location on the display 450, and a contact that corresponds to a location of a contact or gesture performed on the separate touch-sensitive surface (e.g., touch-sensitive surface 451), where the focus selector is, optionally: a respective contact, a representative point corresponding to a contact (e.g., a centroid of a respective contact or a point associated with a respective contact), or a centroid of two or more contacts detected on the touch screen 112 and is, optionally, replaced with a displayed cursor.", "FIGS.", "5A-5M illustrate a portion of a device setup process in which a first fingerprint is enrolled with portable multifunction device 100.FIG.", "5A illustrates portable multifunction device 100 (sometimes herein called device 100) displaying user interface 400 on touch screen 112.In FIG.", "5A, user interface 400 includes a “Set Up Touch ID” interface prompting a user to enroll a fingerprint to serve as the user's touch ID.", "The enrolled fingerprint (e.g., touch ID) can be used to unlock the device in place of a passcode or personal identification number (PIN) and, optionally, to purchase goods or services.", "In FIG.", "5A, the “Set Up Touch ID” interface is displayed during a device set up process.", "For example, the device set up process occurs when a user powers on the device for a first time.", "For example, the device set up process at least includes an, optional, fingerprint enrollment process (e.g., shown in FIGS.", "5B-5K and FIGS.", "5N-5T) and a passcode set up process (e.g., shown in FIG.", "5M).", "The “Set Up Touch ID” interface includes “Set up now” box 502, which, when activated, causes device 100 to start a fingerprint enrollment process and a “Set up later” box 504, which, when activated, causes device 100 to skip the fingerprint enrollment process and display a passcode set up interface (e.g., shown in FIG.", "5M).", "For example, “Set up now” box 502 is activated when a contact (e.g., touch input or tap gesture) is detected at a location inside of or on “Set up now” box 502 or a fingerprint is detected on fingerprint sensor 169.For example, “Set up later” box 504 is activated when a touch input is detected at a location inside of or on “Set up later” box 504.FIG.", "5A also illustrates device 100 detecting contact 506 (e.g., a tap gesture) at a location on touch screen 112 that corresponds to “Set up now” box 502.Alternatively, FIG.", "5A illustrates device 100 detecting fingerprint 508 (e.g., corresponding to a user's right index finger) as part of a first finger gesture (e.g., a first touch and rest gesture) on fingerprint sensor 169 and collecting fingerprint information from the first finger gesture.", "FIG.", "5B illustrates device 100 displaying a first fingerprint enrollment interface for the fingerprint enrollment process on touch screen 112 in response to detecting contact 506 in FIG.", "5A.", "In some embodiments, the fingerprint enrollment process includes at least a first fingerprint enrollment interface (e.g., shown in FIGS.", "5B-5G and 5O-5Q) and a second fingerprint enrollment interface (e.g., shown in FIGS.", "5H-5J and 5R-5S).", "In FIG.", "5B, the first fingerprint enrollment interface includes instructions prompting the user to perform a plurality of separate and distinct stationary finger gestures with a respective finger on fingerprint sensor 169 so as to enroll the fingerprint of the respective finger.", "In FIG.", "5B, the first fingerprint enrollment interface also includes a progress indicator 510 in a first state 510-a.", "For example, in first state 510-a, progress indicator 510 resembles a faux fingerprint with narrow ridges.", "First state 510-a indicates that no fingerprint information has been collected.", "FIG.", "5B also illustrates “Back” affordance 509, which, when activated, causes device 100 to redisplay the “Set Up Touch ID” interface in FIG.", "5A.", "FIG.", "5B further illustrates device 100 detecting fingerprint 512 (e.g., corresponding to the user's right index finger) as part of a first finger gesture (e.g., a first touch and rest gesture) on fingerprint sensor 169 and collecting fingerprint information from the first finger gesture.", "FIG.", "5C illustrates device 100 changing an appearance of progress indicator 510 in response to detecting the first finger gesture.", "For example, the first finger gesture corresponds to fingerprint 508 in FIG.", "5A or, alternatively, fingerprint 512 in FIG.", "5B.", "In FIG.", "5C, device 100 displays progress indicator 510 in second state 510-b.", "In FIG.", "5C, at least a portion of the ridges of progress indicator 510 are thickened (or darkened) in second state 510-b as compared to first state 510-a in FIG.", "5B.", "Second state 510-b of progress indicator 510 indicates that some fingerprint information has been collected but one or more additional finger gestures are required to enroll the first fingerprint (e.g., the fingerprint corresponding to the user's right index finger).", "FIG.", "5C also illustrates device 100 detecting fingerprint 514 (e.g., corresponding to the user's right index finger) as part of a second finger gesture (e.g., a second touch and rest gesture) on fingerprint sensor 169 and collecting fingerprint information from the second finger gesture.", "FIG.", "5D illustrates device 100 displaying a message on touch screen 112 prompting a user to perform subsequent finger gestures differently from the second finger gesture detected in FIG.", "5C.", "In FIG.", "5D, device 100 displays message 516 the first enrollment interface (including progress indicator 510 in second state 510-b) on touch screen 112 in response to detecting the second finger gesture in FIG.", "5C.", "In FIG.", "5D, message 516 includes instructions directing the user to move the respective finger more between each finger gesture so as to collect fingerprint information corresponding to different regions of the fingerprint of the respective finger.", "In some embodiments, message 516 is dismissed and the fingerprint enrollment process is resumed when either a contact is detected at a location corresponding to the “Okay” affordance in message 516 or a subsequent finger gesture is detected on fingerprint sensor 169.FIG.", "5D also illustrates device 100 detecting fingerprint 518 (e.g., corresponding to the user's right index finger) as part of a third finger gesture (e.g., a third touch and rest gesture) on fingerprint sensor 169 and collecting fingerprint information from the third finger gesture.", "FIG.", "5E illustrates device 100 changing an appearance of progress indicator 510 in response to detecting the third finger gesture in FIG.", "5D.", "In FIG.", "5E, device 100 displays progress indicator 510 in third state 510-c.", "In FIG.", "5E, a greater amount of the ridges of progress indicator 510 are thickened in third state 510-c as compared to second state 510-b in FIG.", "5B.", "Third state 510-c of progress indicator 510 indicates that more fingerprint information has been collected but one or more additional finger gestures are required to enroll the first fingerprint (e.g., the fingerprint corresponding to the user's right index finger).", "FIG.", "5E also illustrates device 100 detecting fingerprint 520 (e.g., corresponding to the user's right index finger) as part of a fourth finger gesture (e.g., a fourth touch and rest gesture) on fingerprint sensor 169 and collecting fingerprint information from the fourth finger gesture.", "FIG.", "5F illustrates device 100 displaying a message on touch screen 112 prompting a user to perform subsequent finger gestures differently from the fourth finger gesture detected in FIG.", "5E.", "In FIG.", "5F, device 100 displays message 522 over the first enrollment interface (including progress indicator 510 in third state 510-c) on touch screen 112 in response to detecting the fourth finger gesture in FIG.", "5E.", "In FIG.", "5F, message 522 includes instructions directing the user keep their finger on fingerprint sensor 169 for a longer period of time so as to collect fingerprint information.", "In some embodiments, message 522 includes instructions indicating that the user will feel a vibration that signals when the user can lift their finger from fingerprint sensor 169.In some embodiments, message 522 is dismissed and the fingerprint enrollment process is resumed when either a contact is detected at a location corresponding to the “Okay” affordance in message 522 or a subsequent finger gesture is detected on fingerprint sensor 169.FIG.", "5F also illustrates device 100 detecting contact 524 at a location on touch screen 112 that corresponds to the -Okay” affordance in message 522.FIG.", "5G illustrates device 100 displaying the first fingerprint enrollment interface with progress indicator 510 in third state 510-c in response to detecting contact 524 in FIG.", "5F.", "FIG.", "5G also illustrates device 100 detecting fingerprint 526 (e.g., corresponding to the user's right index finger) as part of a fifth finger gesture (e.g., a fifth touch and rest gesture) on fingerprint sensor 169 and collecting fingerprint information from the fifth finger gesture.", "FIG.", "5H illustrates device 100 displaying a second fingerprint enrollment interface for the fingerprint enrollment process on touch screen 112 and changing an appearance of progress indicator 510 in response to detecting the fifth finger gesture in FIG.", "5G.", "In FIG.", "5H, the second fingerprint enrollment interface includes instructions prompting the user to perform one or more additional separate and distinct stationary finger gestures with the respective finger (e.g., the user's right index finger) on fingerprint sensor 169 so as gather fingerprint information for regions of the fingerprint of the respective finger (e.g., the edges) that are missing from the previously collected fingerprint information in order to complete enrollment of the first fingerprint (e.g., corresponding to the user's right index finger).", "In FIG.", "5H, device 100 displays progress indicator 510 in fourth state 510-d.", "In FIG.", "5H, progress indicator 510 is expanded in fourth state 510-d to reveal a larger perimeter oval of narrow ridges surrounding an inner region of thickened ridges.", "In FIG.", "5H, the inner region of progress indicator 510 corresponds to un-expanded progress indicator 510 included in the first enrollment interface displayed in FIGS.", "5B-5G.", "In this example, a greater amount of the ridges of the inner region of progress indicator 510 are thickened in fourth state 510-d as compared to third state 510-c in FIG.", "5G.", "Fourth state 510-d of progress indicator 510 indicates that more fingerprint information has been collected but one or more additional finger gestures are required to enroll the first fingerprint (e.g., the fingerprint corresponding to the user's right index finger).", "FIG.", "5H also illustrates device 100 detecting fingerprint 528 (e.g., corresponding to the user's right index finger) as part of a sixth finger gesture (e.g., a sixth touch and rest gesture) on fingerprint sensor 169 and collecting fingerprint information from the sixth finger gesture.", "FIG.", "5I illustrates device 100 changing an appearance of progress indicator 510 in response to detecting the sixth finger gesture in FIG.", "5H.", "In FIG.", "5H, device 100 displays progress indicator 510 in fifth state 510-e.", "In FIG.", "5I, a portion of the ridges in the outside perimeter of progress indicator 510 are thickened in fifth state 510-e as compared to fourth state 510-d in FIG.", "5H.", "Fifth state 510-e of progress indicator 510 indicates that more fingerprint information has been collected but one or more additional finger gestures are required to enroll the first fingerprint (e.g., the fingerprint corresponding to the user's right index finger).", "FIG.", "5I also illustrates device 100 detecting fingerprint 530 (e.g., corresponding to the user's right index finger) as part of a seventh finger gesture (e.g., a fourth touch and rest gesture) on fingerprint sensor 169 and collecting fingerprint information from the seventh finger gesture.", "FIG.", "5J illustrates device 100 changing an appearance of progress indicator 510 in response to detecting the seventh finger gesture in FIG.", "5I.", "In FIG.", "5J, device 100 displays progress indicator 510 in sixth state 510-f In FIG.", "5J, all of the ridges in the outside perimeter of progress indicator 510 are thickened in sixth state 510-f.", "In this example, sixth state 510-f of progress indicator 510 indicates that no additional finger gestures are required to enroll the first fingerprint (e.g., the fingerprint corresponding to the user's right index finger).", "FIG.", "5K illustrates device 100 displaying a third fingerprint enrollment interface on touch screen 112 after changing the appearance of progress indicator 510 in FIG.", "5J.", "In FIG.", "5K, the third fingerprint enrollment interface indicates that the first fingerprint (e.g., the fingerprint corresponding to the user's right index finger) has been successfully enrolled with device 100.In FIG.", "5K, the third fingerprint enrollment interface includes “Continue” box 534, which, when activated, causes device 100 to display an interface for the next step in the device set up process.", "FIG.", "5K also illustrates device 100 detecting contact 536 (e.g., a tap gesture) at a location on touch screen 112 that corresponds to “Continue” box 534.FIG.", "5L illustrates device 100 displaying a “Set Up Touch ID for Purchases” interface on touch screen 112 in response to detecting contact 536 in FIG.", "5K.", "The “Set Up Touch ID for Purchases” interface prompts the user to associate the fingerprint enrolled in FIGS.", "5B-5K with purchasing credentials (e.g., store login ID and password, credit card information, billing address, etc.).", "The “Set Up Touch ID for Purchases” interface includes “Set up now” box 538, which, when activated, causes device 100 to start a purchase set up process for associating purchasing credentials with the previously enrolled fingerprint and “Set up later” box 540, which, when activated, causes device 100 to skip the purchase set up process and display a passcode set up interface.", "For example, “Set up now” box 538 is activated when a touch input is detected at a location inside of or on “Set up later” box 538, and “Set up later” box 540 is activated when a touch input is detected at a location inside of or on “Set up later” box 540.FIG.", "5L also illustrates device 100 detecting contact 542 (e.g., a tap gesture) at a location on touch screen 112 that corresponds to “Set up later” box 540.FIG.", "5M illustrates device 100 displaying a passcode set up interface on touch screen 112 in response to detecting contact 542 in FIG.", "5L.", "In FIG.", "5M, the passcode set up interface includes a plurality of soft keys that enable the user to set up a master passcode or PIN for the device.", "FIGS.", "5N-5T illustrate enrolling a second fingerprint with portable multifunction device 100 from a settings interface.", "FIG.", "5N illustrates device 100 displaying a fingerprint settings interface on touch screen 112.In FIG.", "5N, the fingerprint settings interface includes a “Back” affordance 544, which, when activated, causes device 100 to redisplay a previous settings interface different from the fingerprint settings interface and an “Edit” affordance 546, which, when activated, causes device 100 to change an appearance of the fingerprint settings interface and enables the user to delete or edit the names of enrolled fingerprints.", "In FIG.", "5N, the fingerprint settings interface also includes toggle switch 548 configured to turn on/off a passcode unlock function which allows the user to unlock the device with an enrolled fingerprint in place of the passcode, and toggle switch 550 configured to turn on/off the ability to purchase goods and services with an enrolled fingerprint.", "In FIG.", "5N, the passcode unlock function is turned on and the ability to purchase goods and services with an enrolled fingerprint is turned off.", "In FIG.", "5N, the fingerprint settings interface also includes a list of enrolled fingerprints.", "In FIG.", "5N, the list of enrolled fingerprints includes “Fingerprint 1” box 552, which when activated, causes device 100 to change an appearance of “Fingerprint 1” box 552 and to enable the user to edit the name of the enrolled fingerprint, and “Add Fingerprint” box 554, which when activated, causes device 100 to start the fingerprint enrollment process.", "For example, enrolled “Fingerprint 1” corresponds to the first fingerprint (e.g., the fingerprint corresponding to the user's right index finger) enrolled during the enrollment process illustrated in FIGS.", "5B-5K.", "FIG.", "5N further illustrates device 100 detecting contact 556 (e.g., a tap gesture) at a location on touch screen 112 that corresponds to “Add Fingerprint” box 554.FIG.", "5O illustrates device 100 displaying a first fingerprint enrollment interface for the fingerprint enrollment process on touch screen 112 in response to detecting contact 556 in FIG.", "5N.", "In FIG.", "5O, the first fingerprint enrollment interface includes instructions prompting the user to perform a plurality of separate and distinct stationary finger gestures with a respective finger on fingerprint sensor 169 so as to enroll the fingerprint of the respective finger.", "In FIG.", "5O, the first fingerprint enrollment interface also includes a progress indicator 558 in first state 558-a.", "For example, in first state 558-a, progress indicator 558 resembles a faux fingerprint with narrow ridges.", "First state 558-a indicates that no fingerprint information has been collected.", "FIG.", "5O also illustrates “Back” affordance 557, which, when activated, causes device 100 to redisplay the fingerprint settings interface in FIG.", "5N.", "FIG.", "5O further illustrates device 100 detecting fingerprint 560 (e.g., corresponding to the user's left index finger) as part of a first finger gesture (e.g., a first touch and rest gesture) on fingerprint sensor 169 and collecting fingerprint information from the first finger gesture.", "FIG.", "5P illustrates device 100 changing an appearance of progress indicator 558 in response to detecting the first finger gesture in FIG.", "5O.", "In FIG.", "5P, device 100 displays progress indicator 558 in second state 558-b.", "In FIG.", "5P, at least a portion of the ridges of progress indicator 558 are thickened (or darkened) in second state 558-b as compared to first state 558-a in FIG.", "5O.", "Second state 558-b of progress indicator 558 indicates that some fingerprint information has been collected but one or more additional finger gestures are required to enroll the second fingerprint (e.g., the fingerprint corresponding to the user's left index finger).", "FIG.", "5P also illustrates device 100 detecting fingerprint 562 (e.g., corresponding to the user's left index finger) as part of a second finger gesture (e.g., a second touch and rest gesture) on fingerprint sensor 169 and collecting fingerprint information from the second finger gesture.", "FIG.", "5Q illustrates device 100 displaying a message on touch screen 112 prompting a user to perform subsequent finger gestures differently from the second finger gesture detected in FIG.", "5P.", "In FIG.", "5Q, device 100 displays message 564 over the first enrollment interface (including progress indicator 558 in second state 558-b) on touch screen 112 in response to detecting the second finger gesture in FIG.", "5P.", "In FIG.", "5Q, message 564 includes instructions which direct the user to rest their finger on fingerprint sensor 169 (e.g., integrated in home button 204) until a vibration is felt without clicking/depressing home button 204 so as to collect fingerprint information.", "In some embodiments, message 564 is dismissed and the fingerprint enrollment process is resumed when either a contact is detected at a location corresponding to the “Okay” affordance in message 564 or a subsequent finger gesture is detected on fingerprint sensor 169.FIG.", "5Q also illustrates device 100 detecting fingerprint 566 (e.g., corresponding to the user's left index finger) as part of a third finger gesture (e.g., a third touch and rest gesture) on fingerprint sensor 169 and collecting fingerprint information from the third finger gesture.", "FIG.", "5R illustrates device 100 displaying a second fingerprint enrollment interface for the fingerprint enrollment process on touch screen 112 and changing an appearance of progress indicator 558 in response to detecting the third finger gesture in FIG.", "5Q.", "In FIG.", "5R, the second fingerprint enrollment interface includes instructions prompting the user to perform one or more additional separate and distinct stationary finger gestures with the respective finger (e.g., the user's left index finger) on fingerprint sensor 169 so as gather fingerprint information on regions of the fingerprint of the respective finger (e.g., the edges) that are missing from the previously collected fingerprint information in order to complete enrollment of the second fingerprint (e.g., corresponding to the user's left index finger).", "In FIG.", "5R, device 100 displays progress indicator 558 in third state 558-c. For example, progress indicator 510 is expanded in third state 558-c to reveal a larger perimeter oval of narrow ridges surrounding an inner region of thickened ridges.", "In FIG.", "5R, the inner region of progress indicator 558 corresponds to un-expanded progress indicator 558 included in the first enrollment interface displayed in FIGS.", "5O-5Q.", "In this example, a greater amount of the ridges of the inside region of progress indicator 558 are thickened in third state 558-c as compared to second state 510-b in FIG.", "5P.", "Third state 558-c of progress indicator 558 indicates that more fingerprint information has been collected but one or more additional finger gestures are required to enroll the second fingerprint (e.g., the fingerprint corresponding to the user's left index finger).", "FIG.", "5R also illustrates device 100 detecting fingerprint 568 (e.g., corresponding to the user's left index finger) as part of a fourth finger gesture (e.g., a fourth touch and rest gesture) on fingerprint sensor 169 and collecting fingerprint information from the fourth finger gesture.", "FIG.", "5S illustrates device 100 changing an appearance of progress indicator 558 in response to detecting the fourth finger gesture in FIG.", "5R.", "In FIG.", "5S, device 100 displays progress indicator 558 in fourth state 510-d.", "In FIG.", "5S, a portion of the ridges in the outside perimeter of progress indicator 558 are thickened in fourth state 510-d as compared to third state 510-c in FIG.", "5R.", "Fourth state 510-d of progress indicator 558 indicates that more fingerprint information has been collected but one or more additional finger gestures are required to enroll the second fingerprint (e.g., the fingerprint corresponding to the user's left index finger).", "Stated another way, fourth state 510-d of progress indicator 558 is not full, and does not indicate completion, and thereby indicates that one or more additional finger gestures are required to enroll the second fingerprint.", "FIG.", "5S also illustrates device 100 detecting fingerprint 569 (e.g., corresponding to the user's left index finger) as part of a fifth finger gesture (e.g., a fifth touch and rest gesture) on fingerprint sensor 169 and collecting fingerprint information from the fifth finger gesture.", "FIG.", "5T illustrates device 100 displaying a third fingerprint enrollment interface on touch screen 112 in response to detecting the fifth finger gesture in FIG.", "5S.", "In FIG.", "5T, the third fingerprint enrollment interface indicates that the second fingerprint (e.g., the fingerprint corresponding to the user's left index finger) has been successfully enrolled with device 100.In FIG.", "5T, the third fingerprint enrollment interface includes “Continue” box 570, which, when activated, causes device 100 to redisplay the fingerprint settings interface.", "FIG.", "5T also illustrates device 100 detecting contact 572 (e.g., a tap gesture) at a location on touch screen 112 that corresponds to “Continue” box 570.FIGS.", "5U-5W illustrate highlighting an enrolled fingerprint in a fingerprint settings interface when the enrolled fingerprint is detected.", "FIG.", "5U illustrates device 100 displaying the fingerprint settings interface on touch screen 112 in response to detecting contact 570 in FIG.", "5T.", "In FIG.", "5U, the list of enrolled fingerprints includes “Fingerprint 1” box 552, which when activated, causes device 100 to change an appearance of “Fingerprint 1” box 552 and to enable the user to edit the name of the enrolled fingerprint, “Fingerprint 2” box 574, which when activated, causes device 100 to change an appearance of “Fingerprint 2” box 574 and to enable the user to edit the name of the enrolled fingerprint, and “Add Fingerprint” box 554, which when activated, causes device 100 to start the fingerprint enrollment process for enrolling an additional fingerprint.", "For example, enrolled “Fingerprint 1” corresponds to the first fingerprint (e.g., the fingerprint corresponding to the user's right index finger) enrolled during the enrollment process illustrated in FIGS.", "5B-5K, and enrolled “Fingerprint 2” corresponds to the second fingerprint (e.g., the fingerprint corresponding to the user's left index finger) enrolled during the enrollment process illustrated in FIGS.", "5N-5T.", "FIG.", "5U also illustrates device 100 detecting fingerprint 576 (e.g., corresponding to the user's left index finger) on fingerprint sensor 169.In response to detecting fingerprint 576, device 100 highlights, in the list of enrolled fingerprints, the enrolled fingerprint corresponding to the detected fingerprint (if any).", "In FIG.", "5U, for example, device 100 increases the thickness of the border of “Fingerprint 2” box 574 to signify to the user that detected fingerprint 576 corresponds to enrolled “Fingerprint 2.” FIG.", "5V illustrates device 100 detecting fingerprint 578 (e.g., corresponding to the user's right index finger) on fingerprint sensor 169.In response to detecting fingerprint 578, device 100 highlights, in the list of enrolled fingerprints, the enrolled fingerprint corresponding to the detected fingerprint (if any).", "In FIG.", "5V, for example, device 100 increases the thickness of the border of “Fingerprint 1” box 552 to signify to the user that detected fingerprint 578 corresponds to enrolled “Fingerprint 1.” FIG.", "5W illustrates device 100 detecting fingerprint 580 (e.g., corresponding to the user's left thumb).", "In response to detecting fingerprint 580, device 100 does not highlight any enrolled fingerprint in the list of enrolled fingerprints if it determines that the detected fingerprint 580 does not correspond to any of the enrolled fingerprints.", "In FIG.", "5W, for example, device 100 maintains display of the fingerprint settings interface to signify to the user that detected fingerprint 580 does correspond to any of the enrolled fingerprints.", "FIGS.", "5X-5AA illustrate performing a restricted operation when an enrolled fingerprint is detected.", "FIG.", "5X illustrates device 100 displaying a lock screen on touch screen 112.In FIG.", "5X, for example, device 100 is in a locked or restricted access mode.", "FIG.", "5X also illustrates device 100 detecting fingerprint 582 (e.g., corresponding to the user's right index finger) on fingerprint sensor 169.FIG.", "5Y illustrates device 100 displaying a home screen on touch screen 112 in response to detecting fingerprint 582 in FIG.", "5X and in accordance with a determination that fingerprint 582 corresponds to an enrolled fingerprint.", "For example, fingerprint 582 corresponds to the user's right index finger which was enrolled as the first fingerprint in FIGS.", "5B-5K.", "In FIG.", "5Y, for example, device 100 is in an unlocked or unrestricted access mode.", "FIG.", "5Z illustrates device 100 displaying a lock screen on touch screen 112.In FIG.", "5Z, for example, device 100 is in a locked or restricted access mode.", "FIG.", "5Z also illustrates device 100 detecting fingerprint 584 (e.g., corresponding to the user's right thumb) on fingerprint sensor 169.FIG.", "5AA illustrates device 100 maintaining display of the lock screen on touch screen 112 in response to detecting fingerprint 584 in FIG.", "5Z and in accordance with a determination that fingerprint 584 does not correspond to an enrolled fingerprint.", "In FIG.", "5AA, for example, device 100 is in the locked or restricted access mode.", "FIGS.", "5BB-5EE illustrate changing an appearance of a progress indicator in response to a series of separate and distinct stationary finger gestures.", "FIG.", "5BB illustrates the appearance of a progress indicator following a plurality of separate and distinct stationary finger gestures (e.g., touch and rest gestures).", "In FIG.", "5BB, the progress indicator resembles a faux fingerprint with a plurality of ridges.", "In FIG.", "5BB, the ridges of the progress indicator are thickened (or darkened) as fingerprint information is collected from the finger gestures.", "In some embodiments, the ridges of the progress indicator are thickened in accordance with a predefined pattern.", "In FIG.", "5BB, for example, the appearance of the progress indicator is the same after finger gesture 5 as it was after finger gesture 4 because fingerprint information was not collected during finger gesture 5.In this example, fingerprint information was not collected during finger gesture 5 due to the user not resting their finger on the fingerprint sensor for long enough (e.g., message 522 in FIG.", "5F), the user clicking the home button (e.g., message 564 in FIG.", "5Q), or the user failing to move their finger between finger gestures (e.g., message 516 in FIG.", "5D).", "In FIG.", "5BB, the progress indicator expands after finger gesture 7 to indicate that additional fingerprint information needs to be collected for the edges of the fingerprint to enroll the fingerprint.", "FIG.", "5CC illustrates the appearance of a progress indicator following a plurality of separate and distinct stationary finger gestures (e.g., touch and rest gestures).", "In FIG.", "5CC, the progress indicator includes a plurality of concentric circles (e.g., resembling a bull's-eye).", "In FIG.", "5CC, circles (or rings) of the progress indicator are filled in starting from the inner most circle as fingerprint information is collected from the finger gestures.", "In FIG.", "5CC, for example, the appearance of the progress indicator is the same after finger gesture 5 as it was after finger gesture 4 because fingerprint information was not collected during finger gesture 5.In this example, fingerprint information was not collected during finger gesture 5 due to the user not resting their finger on the fingerprint sensor for long enough (e.g., message 522 in FIG.", "5F), the user clicking the home button (e.g., message 564 in FIG.", "5Q), or the user failing to move their finger between finger gestures (e.g., message 516 in FIG.", "5D).", "In FIG.", "5CC, the progress indicator expands after finger gesture 7 to indicate that additional fingerprint information needs to be collected to enroll the fingerprint.", "FIG.", "5DD illustrates the appearance of a progress indicator following a plurality of separate and distinct stationary finger gestures (e.g., touch and rest gestures).", "In FIG.", "5DD, the progress indicator includes a plurality of progress-indicator portions (e.g., hexagonal geometric shapes in a honeycomb layout).", "In FIG.", "5DD, progress-indicator portions (e.g., hexagons) of the progress indicator are filled in relative to the location of the fingerprint information collected from the previous finger gesture.", "In FIG.", "5DD, for example, after finger gesture 1 is performed, progress-indicator portions in the lower left region of the progress indicator are filled in to indicate that fingerprint information for the lower left region of the fingerprint was collected from finger gesture 1.In FIG.", "5DD, the progress indicator expands after finger gesture 6 to indicate that additional fingerprint information needs to be collected for the edges of the fingerprint to enroll the fingerprint.", "In FIG.", "5DD, for example, the appearance of the progress indicator is the same after finger gesture 10 as it was after finger gesture 9 because fingerprint information was not collected during finger gesture 10.In this example, fingerprint information was not collected during finger gesture 10 due to the user not resting their finger on the fingerprint sensor for long enough (e.g., message 522 in FIG.", "5F), the user clicking the home button (e.g., message 564 in FIG.", "5Q), or the user failing to move their finger between finger gestures (e.g., message 516 in FIG.", "5D).", "FIG.", "5EE illustrates the appearance of a progress indicator following a plurality of separate and distinct stationary finger gestures (e.g., touch and rest gestures).", "In FIG.", "5EE, the progress indicator (e.g., a partially displayed sphere) includes a plurality of progress-indicator portions (e.g., boxed regions on the partially displayed sphere).", "In FIG.", "5EE, progress-indicator portions (e.g., boxed regions) of the progress indicator are filled in relative to the location of the fingerprint information collected from the previous finger gesture.", "In FIG.", "5EE, for example, after finger gesture 1 is performed, progress-indicator portions near the origin of the equator of the progress indicator are filled in to indicate that fingerprint information for the middle of the fingerprint was collected from finger gesture 1.In FIG.", "5EE, for example, the appearance of the progress indicator is the same after finger gesture 9 as it was after finger gesture 8 because fingerprint information was not collected during finger gesture 9.In this example, fingerprint information was not collected during finger gesture 9 due to the user not resting their finger on the fingerprint sensor for long enough (e.g., message 522 in FIG.", "5F), the user clicking the home button (e.g., message 564 in FIG.", "5Q), or the user failing to move their finger between finger gestures (e.g., message 516 in FIG.", "5D).", "FIGS.", "6A-6D are flow diagrams illustrating a method 600 of enrolling fingerprints with a device in accordance with some embodiments.", "Method 600 is performed at an electronic device (e.g., device 300, FIG.", "3, or portable multifunction device 100, FIG.", "1A) with a display and a fingerprint sensor.", "In some embodiments, the display is a touch screen display and the fingerprint sensor is on the display.", "In some embodiments, the display is separate from the fingerprint sensor.", "Some operations in method 600 are, optionally, combined and/or the order of some operations is, optionally, changed.", "As described below, method 600 provides an intuitive way to enroll fingerprints with a device.", "The method reduces the cognitive burden on a user when enrolling fingerprints with a device, thereby creating a more efficient human-machine interface.", "For battery-operated electronic devices, enabling a user to enroll fingerprints with a device faster and more efficiently conserves power and increases the time between battery charges.", "The devices displays (602) a fingerprint enrollment interface.", "In some embodiments, the fingerprint enrollment interface is displayed as part of a device set up process.", "For example, FIGS.", "5A-5M illustrate a device set up process including a fingerprint enrollment process in FIGS.", "5B-5K, a purchase set up process in FIG.", "5L, and a passcode set up process in FIG.", "5M.", "In FIGS.", "5B-5K, the fingerprint enrollment process includes a first enrollment interface in FIGS.", "5B-5G with an un-expanded progress indicator, a second enrollment in FIGS.", "5H-5J with an expanded progress indicator, and a third enrollment interface in FIG.", "5K with text indicating that the fingerprint enrollment process was successful.", "In some embodiments, during the device setup process, the fingerprint enrollment interface is displayed before displaying a passcode set up interface.", "For example, the fingerprint enrollment process shown in FIGS.", "5B-5K occurs prior to the display of the passcode set up interface in FIG.", "5M in response to detecting contact 506 at a location corresponding to “Set up now” box 502 in FIG.", "5A.", "In some embodiments, if the fingerprint enrollment interface is dismissed without enrolling a fingerprint, a passcode set up interface is displayed.", "For example, in response to detecting a contact at a location corresponding to “Set up later” box 504 in FIG.", "5A, the device displays the passcode set up interface in FIG.", "5M.", "In some embodiments, the fingerprint enrollment interface is displayed as part of a device settings user interface.", "For example, FIGS.", "5O-5T illustrate a fingerprint enrollment process initiated in response to detecting contact 556 at a location corresponding to “Add Fingerprint” box 554 in the fingerprint settings interface in FIG.", "5N.", "In FIGS.", "5O-5T, the fingerprint enrollment process includes a first enrollment interface in FIGS.", "5O-5Q with an un-expanded progress indicator, a second enrollment in FIGS.", "5R-5S with an expanded progress indicator, and a third enrollment interface in FIG.", "5T with text indicating that the fingerprint enrollment process was successful.", "The device detects (604) on the fingerprint sensor a plurality of separate and distinct stationary finger gestures performed with a respective finger.", "For example, the plurality of separate and distinct stationary finger gestures are gestures in which the respective finger does not move laterally across the fingerprint sensor, such as tap and hold gestures on the fingerprint sensor.", "Thus, in some embodiments, the plurality of finger gestures are not swipe gestures over the fingerprint sensor.", "For example, device 100 detects seven separate and distinct finger gestures (e.g., touch and rest gestures) on fingerprint sensor 169 during the fingerprint enrollment process illustrated in FIGS.", "5B-5K.", "As another example, device 100 detects five separate and distinct finger gestures (e.g., touch and rest gestures) on fingerprint sensor 169 during the fingerprint enrollment process illustrated in FIGS.", "5N-5T.", "The device collects (606) fingerprint information from the plurality of separate and distinct stationary finger gestures performed with the respective finger.", "For example, device 100 collects (or attempts to collect) fingerprint information from the fingerprint detected on fingerprint sensor 169 as part of each of the seven separate and distinct finger gestures (e.g., touch and rest gestures) during the fingerprint enrollment process illustrated in FIGS.", "5B-5K.", "As another example, device 100 collects (or attempts to collect) fingerprint information from the fingerprint detected on fingerprint sensor 169 as part of each of the seven separate and distinct finger gestures (e.g., touch and rest gestures) during the fingerprint enrollment process illustrated in FIGS.", "5N-5T.", "In some embodiments, fingerprint information from the plurality of separate and distinct stationary finger gestures is collected (608) for an area of the fingerprint of the respective finger that is at least twice as large as the area that can be captured by the fingerprint sensor during a single stationary finger gesture.", "For example, the whole fingerprint cannot be captured based on a single stationary finger gesture because the fingerprint sensor is substantially smaller than the relevant area of the fingerprint.", "In some embodiments, the fingerprint information collected from the plurality of separate and distinct stationary finger gestures corresponds to more than a 100 mm2 area of the fingerprint of the respective finger while the fingerprint sensor has smaller sensor area such as 50 mm2 or 25 mm2 or less.", "In some embodiments, while the respective finger is on the fingerprint sensor during a respective stationary gesture, the device: collects (610) fingerprint information; and after the fingerprint information has been collected, provides haptic feedback at the device to indicate that the fingerprint information has been collected.", "For example, the device vibrates slightly to indicate to the user that fingerprint information for the current stationary finger gesture has been collected and that a next finger gesture can be performed.", "In some embodiments, it takes the device a respective amount of time to collect fingerprint information and the haptic feedback is provided after the finger has been on the fingerprint sensor for at least the respective amount of time.", "For example, message 522 in FIG.", "5F indicates that device 100 was unable to collect fingerprint information from the fourth finger gesture detected in FIG.", "5E because the user did not rest their finger on fingerprint sensor 169 for a time period long enough to collect fingerprint information.", "In some embodiments, message 522 includes instructions directing the user to rest their finger on fingerprint sensor 169 integrated in home button 204 until the user feels a slight vibration indicating that fingerprint was collected and that the user can lift their finger from fingerprint sensor 169.In some implementations, the respective amount of time to collect fingerprint information from each fingerprint gesture is less than one second.", "In some implementations, the respective amount of time to collect fingerprint information from each fingerprint gesture is less than one second and greater than 0.1 seconds.", "In some implementations, the respective amount of time to collect fingerprint information from each fingerprint gesture is at least 0.25 seconds and no greater the 0.75 seconds.", "In some embodiments, the fingerprint enrollment interface includes (612) a progress indicator, and in response to detecting on the fingerprint sensor a respective stationary finger gesture performed with the respective finger, the device changes an appearance of the progress indicator to indicate the collection of additional fingerprint information from the respective stationary finger gesture.", "In FIGS.", "5B-5K, the fingerprint enrollment process includes a first enrollment interface in FIGS.", "5B-5G with an un-expanded progress indicator and a second enrollment in FIGS.", "5H-5J with an expanded progress indicator.", "In this example, an appearance of the progress indicator is changed (e.g., ridges are thickened) as fingerprint information is collected from the plurality of separate and distinct finger gestures (e.g., touch and rest finger gestures).", "In some embodiments, the fingerprint enrollment interface also includes a message prompting a user to rest their finger on the fingerprint sensor in a representative manner, and the progress indicator is a faux/stock fingerprint.", "For example, the first enrollment interface in FIGS.", "5B-5G includes instructions directing the user to perform multiple finger gestures (e.g., touch and rest gestures) on fingerprint sensor 169 integrated in home button 204.In FIGS.", "5B-5J, for example, progress indicator 510 resembles a faux fingerprint.", "In some embodiments, the changes in the appearance of the progress indicator illustrate the amount of collected fingerprint information relative to an amount of fingerprint information necessary to enroll the fingerprint.", "FIGS.", "5BB-5EE illustrate changes in the appearance of different progress indicators following a plurality of separate and distinct finger gestures (e.g., touch and rest gestures).", "Each of the progress indicators in FIGS.", "5BB-5EE illustrate the amount of fingerprint information collected compared to the amount of fingerprint information necessary to enroll the fingerprint.", "In FIG.", "5BB, for example, thick ridges indicate an amount of fingerprint information that has been collected and narrow ridges indicate an amount of fingerprint information that has not been collected.", "In FIG.", "5CC, for example, filled (or shaded) circles/rings indicate fingerprint information that has been collected and the total number of circles/rings indicate the total amount of fingerprint information that is necessary to enroll the fingerprint.", "In FIG.", "5DD, for example, filled (or shaded) hexagons indicate fingerprint information that has been collected and the total number of hexagons indicate the total amount of fingerprint information that is necessary to enroll the fingerprint.", "In FIG.", "5EE, for example, filled (or shaded) boxed regions of the partially displayed sphere indicate fingerprint information that has been collected and the total number of boxed regions of the partially displayed sphere indicate the total amount of fingerprint information that is necessary to enroll the fingerprint.", "In some embodiments, as additional fingerprint information is collected, portions of the progress indicator are filled in, in a predefined sequence, without regard to which fingerprint portion was detected.", "In FIGS.", "5B-5J, for example, the ridges of progress indicator 510 are thickened in accordance with a predefined pattern without regard to which fingerprint portion was detected.", "In some embodiments, the portions of the progress indicator are filled in based on the portions of the fingerprint for which fingerprint information has been collected.", "In FIG.", "5DD, for example, the progress indicator includes a plurality of progress-indicator portions (e.g., hexagonal geometric shapes in a honeycomb layout).", "In FIG.", "5DD, progress-indicator portions (e.g., hexagons) of the progress indicator are filled in relative to the location of the fingerprint information collected from the previous finger gesture.", "In FIG.", "5EE, the progress indicator (e.g., a partially displayed sphere) includes a plurality of progress-indicator portions (e.g., boxed regions on the partially displayed sphere).", "In FIG.", "5EE, progress-indicator portions (e.g., boxed regions) of the progress indicator are filled in relative to the location of the fingerprint information collected from the previous finger gesture.", "In some embodiments, the progress indicator includes (614) a portion of a surface of a three-dimensional object (e.g., a sphere or other ellipsoid).", "In FIG.", "5EE, the progress indicator resembles a sphere where a portion of the sphere's surface is displayed.", "In some embodiments, the progress indicator is (616) in the shape of a fingerprint (e.g., a stock or faux fingerprint) and includes lines that are representative of fingerprint ridges and changing the appearance of the progress indicator includes coloring in a portion of the plurality of ridges.", "In FIG.", "5BB, for example, the progress indicator resembles a faux fingerprint with a plurality of ridges.", "In this example, ridges of the progress indicator are thickened or colored as fingerprint information is collected from the plurality of finger gestures.", "In some embodiments, the progress indicator includes (618) a plurality of concentric circles and changing the appearance of the progress indicator includes filling in one of a plurality of concentric circles with a predefined fill (e.g., a predefined color and/or pattern).", "In FIG.", "5CC, the progress indicator includes a plurality of concentric circles (e.g., resembling a bull's-eye).", "In some embodiments, the concentric circles are filled with the predefined fill starting from the innermost circle to the outermost circle.", "In FIG.", "5CC, circles (or rings) of the progress indicator are filled in starting from the inner most circle as fingerprint information is collected from the finger gestures.", "In some embodiments, the concentric circles are filled with the predefined fill starting from the outermost circle to the innermost circle.", "In some embodiments, the progress indicator includes (620) a plurality of progress-indicator portions that correspond to fingerprint portions of the respective fingerprint, and when fingerprint information from a respective fingerprint portion is collected, the device changes an appearance of the corresponding progress-indicator portion to indicate that fingerprint information from the respective fingerprint portion has been collected.", "In some embodiments, the progress-indicator portions are representations of fingerprint ridges.", "For example, after each finger gesture, a region of the user's fingerprint corresponding to the fingerprint information collected from the previous finger gesture is presented in the progress indicator.", "In this example, the progress indicator resembles a representative image of the user's fingerprint that is built-up from the plurality finger gestures (e.g., a patchwork of images or scans of the user's fingerprint).", "In this example, once a complete representative image of the user's fingerprint is presented, the user's fingerprint is enrolled with the device.", "In some embodiments, the representative image of the user's fingerprint is deleted from the device upon enrollment of the fingerprint.", "In some embodiments, the progress-indicator portions are geometric shapes (e.g., hexagons in a honeycomb layout).", "In FIG.", "5DD, the progress indicator resembles a honeycomb layout with a plurality of progress-indicator portions where each progress-indicator portion is a hexagonal geometric shape.", "In FIG.", "5DD, the hexagons of the progress indicator are filled in relative to the location of the fingerprint information collected from the previous finger gesture.", "In FIG.", "5EE, the progress indicator resembles a partially displayed sphere with a plurality of progress-indicator portions where each progress-indicator portion is a boxed regions on the partially displayed sphere.", "In FIG.", "5EE, the boxed regions of the progress indicator are filled in relative to the location of the fingerprint information collected from the previous finger gesture.", "After collecting the fingerprint information, the device determines (622), based on fingerprint information collected for the respective finger, whether the fingerprint information that has been collected is sufficient to enroll a fingerprint of the respective finger with the device.", "In some embodiments, a maximum number of images captured from each finger gesture are able to be combined to produce the necessary fingerprint information.", "For example, in some implementations, a maximum of 15 images from each of 15 finger gestures may be combined to produce the necessary fingerprint information.", "In some embodiments, the collected fingerprint information is sufficient to enroll the fingerprint of the respective finger when the collected fingerprint information satisfies predefined criteria.", "In some embodiments, the predefined criteria include a threshold amount of fingerprint information (e.g., a threshold amount of surface area).", "In some embodiments, the threshold amount of fingerprint information is a predefined minimum amount of non-overlapping fingerprint area.", "For example, 15 images collected from each of 15 finger gestures are combined to produce at least 200 mm2 of non-overlapping area of a fingerprint, where 200 mm2 is the predefined minimum amount of area necessary to enroll a fingerprint.", "In some embodiments, the threshold amount of fingerprint information is a multiple of the surface area of the fingerprint sensor.", "For example, when the fingerprint sensor is 25 mm2, a sufficient amount of fingerprint information is an amount of non-overlapping fingerprint area that is 8 times the surface area of the fingerprint sensor (e.g., 200 mm2).", "In some embodiments, the predefined criteria include a predetermined quality of images collected from the plurality of finger gestures.", "For example, if the user's fingerprint from a respective finger gesture is too dirty, too faint, or otherwise fails to meet some other predetermined standard, the quality of the image collected from that finger gesture will not satisfy the quality criterion.", "In some embodiments, the predefined criteria require a predefined degree of contiguousness between images collected from the plurality of finger gestures.", "In some embodiments, the predefined criteria require that the fingerprint information collected be from a same finger.", "In accordance with a determination that the fingerprint information that has been collected for the respective finger is sufficient to enroll the fingerprint of the respective finger, the device enrolls (624) the fingerprint of the respective finger with the device.", "In FIG.", "5K, for example, device 100 determines that the first fingerprint (e.g., the fingerprint corresponding to the user's right index finger) has been successfully enrolled with device 100 after detecting the seventh finger gesture in FIG.", "5I.", "In FIG.", "5T, for example, device 100 determines that the second fingerprint (e.g., the fingerprint corresponding to the user's left index finger) has been successfully enrolled with device 100 after detecting the fifth finger gesture in FIG.", "5S.", "In accordance with a determination that the fingerprint information that has been collected for the respective finger is not sufficient to enroll the fingerprint of the respective finger, the device displays (626) a message in the fingerprint enrollment interface prompting a user to perform one or more additional stationary finger gestures on the fingerprint sensor with the respective finger.", "In FIGS.", "5C-5I, for example, device 100 determines that the fingerprint information collected for the respective finger is not sufficient to enroll the fingerprint of the respective finger.", "In FIGS.", "5C-5G, for example, device 100 displays instructions in a first fingerprint enrollment interface directing the user to perform one or more additional finger gestures on fingerprint sensor 169, which is integrated in home button 204, and, in FIGS.", "5H-5I, for example, device 100 displays instructions in a second fingerprint enrollment interface directing the user to adjust their grip when performing one or more additional finger gestures on fingerprint sensor 169 integrated in home button 204 so as to capture the edges of the fingerprint.", "In some embodiments, the message prompting the user to perform one or more additional finger gestures includes (628) displayed instructions to perform subsequent finger gestures differently from the respective finger gesture.", "In some embodiments, device 100 displays one of a plurality of predefined messages or warning notifications so as to encourage the user to perform subsequent finger gestures in a manner in which fingerprint information can be properly collected.", "In some embodiments, the displayed message (628) includes displayed instructions to move the finger more between each finger gesture on the fingerprint sensor to collect information from the fingerprint with fewer finger gestures (e.g., “Move finger.", "Move your finger slightly between scans.”).", "For example, message 516 in FIG.", "5D indicates that device 100 was unable to collect fingerprint information from the second finger gesture detected in FIG.", "5C because the user did not move their finger slightly as compared to the location of the first finger gesture.", "In some embodiments, while displaying the instructions to move the user's finger more between each finger gesture on the fingerprint sensor, device 100 provides negative haptic feedback (e.g., two consecutive vibrations) to get the user's attention and inform the user that device 100 was unable to collect fingerprint information from the previous finger gesture.", "In some embodiments, the message includes displayed instructions to leave the finger on the fingerprint sensor for a longer period of time (e.g., “Please keep your finger on sensor.”).", "For example, message 522 in FIG.", "5F indicates that device 100 was unable to collect fingerprint information from the fourth finger gesture detected in FIG.", "5E because the user did not rest their finger on fingerprint sensor 169 for a time period long enough to collect fingerprint information.", "In some embodiments, while displaying the message that includes displayed instructions to leave the user's finger on fingerprint sensor 169 for a longer period of time, device 100 provides negative haptic feedback (e.g., two consecutive vibrations) to get the user's attention and inform the user that device 100 was unable to collect fingerprint information from the previous finger gesture.", "In some embodiments, the message includes displayed instructions to apply less pressure on the fingerprint sensor (e.g., “Oops.", "You clicked.", "Rest your finger on the home button until you feel a vibration without clicking it.”).", "For example, message 564 in FIG.", "5Q indicates that device 100 was unable to collect fingerprint information from the second finger gesture detected in FIG.", "5P because the user clicked home button 204 instead of resting their finger on fingerprint sensor 169, integrated in home button 204.In some embodiments, while displaying the instructions to apply less pressure on fingerprint sensor 169, device 100 provides negative haptic feedback (e.g., two consecutive vibrations) to get the user's attention and to inform the user that the user needs to rest their finger on fingerprint sensor 169 without clicking or depressing home button 204.In some embodiments, in which the fingerprint enrollment process is alignment dependent, the message includes displayed instructions to properly align the finger on fingerprint sensor 169 with a representation of proper finger alignment.", "In some such embodiments, while displaying the instructions to properly align the finger on fingerprint sensor 169, device 100 provides negative haptic feedback (e.g., two consecutive vibrations).", "However, in some other embodiments, the enrollment process is alignment independent.", "In some embodiments, the message prompting the user to perform one or more additional finger gestures includes (630) an indication of one or more portions or locations of the respective fingerprint for which fingerprint information is inadequate or has not been collected (e.g., the message indicates that edges of the fingerprint are missing from the collected fingerprint information).", "In some embodiments, the message includes displayed instructions to change the part of the fingerprint that is in contact with the fingerprint sensor so that the device is able to capture a particular part of a fingerprint (e.g., instructions to place an edge of the finger on the fingerprint sensor), so that the device is able to capture a larger variety of fingerprint information (e.g., instructions to move the finger around more in between finger gestures).", "In FIGS.", "5H-5I and 5R-5S, for example, device 100 displays instructions in a second fingerprint enrollment interface directing the user to adjust their grip when performing one or more additional finger gestures on fingerprint sensor 169 integrated in home button 204 so as to capture the edges of the fingerprint.", "In some embodiments, the message includes displayed instructions to change the part of the fingerprint that is in contact with the fingerprint sensor so that the device is better able to combine the information from the plurality of stationary finger gestures (e.g., instructions to move the finger around less in between finger gestures).", "In some embodiments, after changing the appearance of a plurality of progress-indicator portions (e.g., by coloring in the plurality of progress-indicator portions with a respective color) and in accordance with a determination that the fingerprint information that has been collected for the respective finger is sufficient to enroll the fingerprint of the respective finger, the device changes (632) the appearance of one or more unchanged progress-indicator portions to match the appearance of the plurality of progress-indicator portions (e.g., by coloring in the entirety of the fingerprint shape in the progress indicator with the respective color).", "In FIG.", "5J, for example, device 100 darkens or thickens all of the ridges of progress indicator 510 (in comparison to FIG.", "5I) in accordance with the determination that the fingerprint information collected after detecting the seventh finger gesture in FIG.", "5I is sufficient to enroll the fingerprint.", "In FIG.", "5CC, for example, device 100 flood fills the progress indicator after detecting finger gesture 12 in accordance with the determination that the fingerprint information collected after detecting finger gesture 12 is sufficient to enroll the fingerprint.", "In some embodiments, after enrolling fingerprint of the respective finger with the device, the device receives (634) a request to perform a restricted operation (e.g., unlocking the device, purchasing content or applications for the device, or displaying private information on the device), and the device detects a fingerprint on the fingerprint sensor.", "In FIG.", "5X, for example, after enrolling the first fingerprint (e.g., corresponding to the user's right index finger) in FIGS.", "5B-5K and the second fingerprint (e.g., corresponding to the user's left index finger) in FIGS.", "5N-5T, device 100 receives a request to perform a restricted operation (e.g., unlock device 100) while the lock screen is displayed on touch screen 112.In this example, the request to perform the restricted operation includes a fingerprint 582 (e.g., corresponding to the user's right index finger) on fingerprint sensor 169.In FIG.", "5Z, for example, after enrolling the first fingerprint (e.g., corresponding to the user's right index finger) in FIGS.", "5B-5K and the second fingerprint (e.g., corresponding to the user's left index finger) in FIGS.", "5N-5T, device 100 receives a request to perform a restricted operation (e.g., unlock device 100) while the lock screen is displayed on touch screen 112.In this example, the request includes fingerprint 584 (e.g., corresponding to the user's right thumb) on fingerprint sensor 169.In some embodiments, in response to receiving (636) the request to perform the restricted operation and in accordance with a determination that the fingerprint is enrolled with the device, the device performs (638) the restricted operation.", "In FIG.", "5Y, for example, in response to receiving the request to unlock device 100 in FIG.", "5X and in accordance with a determination that fingerprint 582 is an enrolled fingerprint, device 100 unlocks (e.g., the restricted operation) and displays the home screen with a plurality of application icons on touch screen 112.In some embodiments, in response to receiving (636) the request to perform the restricted operation and in accordance with a determination that the fingerprint is not enrolled with the device, the device forgoes (640) performance of the restricted operation.", "In FIG.", "5AA, for example, in response to receiving the request to unlock device 100 in FIG.", "5Z and in accordance with a determination that fingerprint 584 is not an enrolled fingerprint, device 100 maintains display of the lock screen on touch screen 112 and forgoes unlocking (e.g., the restricted operation).", "In some embodiments, after enrolling the fingerprint of the respective finger with the device, the device: displays (642) a fingerprint settings interface with a plurality of entries (e.g., a plurality of entries in a list) that correspond to respective enrolled fingerprints, where the plurality of entries includes a respective entry that corresponds to the fingerprint of the respective finger and one or more other entries that correspond to other enrolled fingerprints of other fingers besides the respective finger; detecting a second finger gesture on the fingerprint sensor that corresponds to the fingerprint of the respective finger; and in response to detecting the second finger gesture, highlighting the respective entry that corresponds to the fingerprint of the respective finger (e.g., displaying a frame around the entry, increasing the line thickness of the entry, changing a text or fill color of the entry, etc.).", "In FIGS.", "5U-5W, for example, device 100 displays a fingerprint settings interface on touch screen 112 with a list of enrolled fingerprints.", "In this example, the list of enrolled fingerprints include “Fingerprint 1” box 552 associated with the first fingerprint enrolled in FIGS.", "5N-5T (e.g., corresponding to the user's right index finger) and “Fingerprint 2” box 574 associated with the second fingerprint enrolled in FIGS.", "5B-5K (e.g., corresponding to the user's left index finger).", "In FIG.", "5U, for example, in response to detecting fingerprint 576 (e.g., corresponding to the user's left index finger) on fingerprint sensor 169, device 100 increases the line thickness of (or otherwise highlights) “Fingerprint 2” box 574 to indicate that detected fingerprint 576 corresponds to the enrolled “Fingerprint 2.” In FIG.", "5V, for example, in response to detecting fingerprint 578 (e.g., corresponding to the user's right index finger) on fingerprint sensor 169, device 100 increases the line thickness of (or otherwise highlights) “Fingerprint 1” box 552 to indicate that detected fingerprint 578 corresponds to the enrolled “Fingerprint 1.” In FIG.", "5W, for example, in response to detecting fingerprint 580 (e.g., corresponding to the user's left thumb) on fingerprint sensor 169, device 100 maintains display of the fingerprint settings interface to indicate that detected fingerprint 580 does not correspond to any of the enrolled fingerprints.", "In some embodiments, a given entry can be renamed (e.g., by typing in a new name for the entry while the fingerprint settings interface is in an edit mode) and/or deleted (e.g., by swiping across the entry and selecting a delete affordance that is displayed in response to detecting the swiping across the entry).", "In FIG.", "5N, for example, device 100 displays a fingerprint settings interface on touch screen 112 with “Edit” affordance 546.“Edit” affordance 546, which, when activated, causes device 100 to change an appearance of the fingerprint settings interface (e.g., displaying a delete affordance next to each of the enrolled fingerprints) and causes device 100 to enter an edit mode whereby a user is enabled to delete or edit the names of enrolled fingerprints.", "In some embodiments, a limited number of fingerprints (e.g., 3, 5, 10 or other reasonable number) are allowed to be enrolled at a time so as to limit the amount of time that it takes to determine whether a fingerprint detected on the fingerprint sensor matches an enrolled fingerprint.", "For example, in some implementations, the number of enrolled fingerprints is limited such that a determination of whether a fingerprint detected on the fingerprint sensor matches an enrolled fingerprint can be completed within 0.5 seconds.", "It should be understood that the particular order in which the operations in FIGS.", "6A-6D have been described is merely exemplary and is not intended to indicate that the described order is the only order in which the operations could be performed.", "One of ordinary skill in the art would recognize various ways to reorder the operations described herein.", "Additionally, it should be noted that details of other processes described herein with respect to other methods described herein (e.g., those listed in the “Description of Embodiments” section above) are also applicable in an analogous manner to method 600 described above with respect to FIGS.", "6A-6D.", "For example, the fingerprints and gestures described above with reference to method 600 optionally have one or more of the characteristics of the fingerprints and gestures described herein with reference to other methods described herein (e.g., those listed in the “Description of Embodiments” section above).", "For brevity, these details are not repeated here.", "In accordance with some embodiments, FIG.", "7 shows a functional block diagram of an electronic device 700 configured in accordance with the principles of the various described embodiments.", "The functional blocks of the device are, optionally, implemented by hardware, software, or a combination of hardware and software to carry out the principles of the various described embodiments.", "It is understood by persons of skill in the art that the functional blocks described in FIG.", "7 are, optionally, combined or separated into sub-blocks to implement the principles of the various described embodiments.", "Therefore, the description herein optionally supports any possible combination or separation or further definition of the functional blocks described herein.", "As shown in FIG.", "7, electronic device 700 includes a display unit 702 configured to display a fingerprint enrollment interface and a fingerprint sensor unit 704.In some embodiments, electronic device 700, optionally, includes a touch-sensitive surface unit 706 configured to receive one or more touch inputs and a haptic feedback unit configured to provide haptic feedback.", "Electronic device 700 also includes a processing unit 710 coupled to display unit 702 and fingerprint sensor unit 704, and, optionally, coupled to touch-sensitive surface unit 706 and haptic feedback unit 708.In some embodiments, processing unit 710 includes a detecting unit 712, a collecting unit 714, a determining unit 716, an enrolling unit 718, a display enabling unit 720, a receiving unit 722, a performing unit 724, a highlighting unit 726, and an appearance changing unit 728.Processing unit 710 is configured to: detect (e.g., with detecting unit 712) on fingerprint sensor unit 704 a plurality of separate and distinct stationary finger gestures performed with a respective finger; and collect (e.g., with collecting unit 714) fingerprint information from the plurality of separate and distinct stationary finger gestures performed with the respective finger.", "After collecting the fingerprint information, processing unit 710 is configured to determine (e.g., with determining unit 716), based on the fingerprint information collected for the respective finger, whether the fingerprint information that has been collected is sufficient to enroll a fingerprint of the respective finger with the device.", "In accordance with a determination that the fingerprint information that has been collected for the respective finger is sufficient to enroll the fingerprint of the respective finger, processing unit 710 is configured to enroll (e.g., with enrolling unit 718) the fingerprint of the respective finger with electronic device 700.In accordance with a determination that the fingerprint information that has been collected for the respective finger is not sufficient to enroll the fingerprint of the respective finger, processing unit 710 is configured to enable display of (e.g., with the display enabling unit 720) a message in the fingerprint enrollment interface prompting a user to perform one or more additional stationary finger gestures on fingerprint sensor unit 704 with the respective finger.", "In some embodiments, fingerprint information from the plurality of separate and distinct stationary finger gestures is collected for an area of the fingerprint of the respective finger that is at least twice as large as the area that can be captured by fingerprint sensor unit 704.In some embodiments, processing unit 710 is configured to receive (e.g., with receiving unit 722) a request to perform a restricted operation and detect (e.g., with detecting unit 712) a fingerprint on fingerprint sensor 704.In response to receiving the request to perform the restricted operation, processing unit 710 is configured to: in accordance with a determination that the fingerprint is enrolled with the device, perform (e.g., with the performing unit 724) the restricted operation; and in accordance with a determination that the fingerprint is not enrolled with the device, forgo performance of the restricted operation.", "In some embodiments, the message prompting the user to perform one or more additional finger gestures includes displayed instructions to perform subsequent finger gestures differently from the respective finger gesture.", "In some embodiments, the message prompting the user to perform one or more additional finger gestures includes an indication of one or more portions or locations of the respective fingerprint for which fingerprint information is inadequate or has not been collected.", "In some embodiments, processing unit 710 is configured to collect (e.g., with collecting unit 714) fingerprint information while the respective finger is on fingerprint sensor unit 704 during a respective stationary gesture.", "Electronic device 700 includes a haptic feedback unit 708 configured to, after the fingerprint information has been collected, provide haptic feedback at electronic device 700 to indicate that the fingerprint information has been collected.", "In some embodiments, after enrolling the fingerprint of the respective finger with electronic device 700, processing unit 710 is configured to: enable display of (e.g., with display enabling unit 720) a fingerprint settings interface with a plurality of entries that correspond to respective enrolled fingerprints, where the plurality of entries includes a respective entry that corresponds to the fingerprint of the respective finger and one or more other entries that correspond to other enrolled fingerprints of other fingers besides the respective finger; detect (e.g., with detecting unit 712) a second finger gesture on fingerprint sensor unit 704 that corresponds to the fingerprint of the respective finger; and in response to detecting the second finger gesture, highlight (e.g., with highlighting unit 726) the respective entry that corresponds to the fingerprint of the respective finger.", "In some embodiments, the fingerprint enrollment interface includes a progress indicator, and, in response to detecting on fingerprint sensor unit 704, processing unit 710 is configured to change (e.g., with appearance changing unit 728) an appearance of the progress indicator to indicate the collection of additional fingerprint information from the respective stationary finger gesture.", "In some embodiments, the progress indicator includes a portion of a surface of a three-dimensional object.", "In some embodiments, the progress indicator is in the shape of a fingerprint and includes lines that are representative of fingerprint ridges, and changing the appearance of the progress indicator includes coloring (e.g., with appearance changing unit 728) in a portion of the plurality of ridges.", "In some embodiments, the progress indicator includes a plurality of concentric circles, and changing the appearance of the progress indicator includes filling (e.g., with appearance changing unit 728) in one of a plurality of concentric circles with a predefined fill.", "In some embodiments, the progress indicator includes a plurality of progress-indicator portions that correspond to fingerprint portions of the respective fingerprint, and when fingerprint information from a respective fingerprint portion is collected, processing unit 710 is configured to change (e.g., with appearance changing unit 728) an appearance of the corresponding progress-indicator portion to indicate that fingerprint information from the respective fingerprint portion has been collected.", "In some embodiments, processing unit 710 is configured, after changing the appearance of a plurality of progress-indicator portions and in accordance with a determination that the fingerprint information that has been collected for the respective finger is sufficient to enroll the fingerprint of the respective finger, to change (e.g., with appearance changing unit 728) the appearance of one or more unchanged progress-indicator portions to match the (already changed) appearance of the plurality of progress-indicator portions.", "The operations in the information processing methods described above are, optionally implemented by running one or more functional modules in information processing apparatus such as general purpose processors (e.g., as described above with respect to FIGS.", "1A and 3) or application specific chips.", "The operations described above with reference to FIGS.", "6A-6D are, optionally, implemented by components depicted in FIGS.", "1A-1B or FIG.", "7.For example, detecting operation 602, collecting operation 606, determining operation 622, and enrolling operation 624 are, optionally, implemented by event sorter 170, event recognizer 180, and event handler 190.Event monitor 171 in event sorter 170 detects a contact on touch-sensitive display 112, and event dispatcher module 174 delivers the event information to application 136-1.A respective event recognizer 180 of application 136-1 compares the event information to respective event definitions 186, and determines whether a first contact at a first location on the touch-sensitive surface corresponds to a predefined event or sub-event, such as selection of an object on a user interface.", "When a respective predefined event or sub-event is detected, event recognizer 180 activates an event handler 190 associated with the detection of the event or sub-event.", "Event handler 190 optionally utilizes or calls data updater 176 or object updater 177 to update the application internal state 192.In some embodiments, event handler 190 accesses a respective GUI updater 178 to update what is displayed by the application.", "Similarly, it would be clear to a person having ordinary skill in the art how other processes can be implemented based on the components depicted in FIGS.", "1A-1B.", "Performing Operations Based on Fingerprints Many electronic devices are configured to perform various operations.", "Existing methods for performing operations typically require performing a respective operation in response to a respective input.", "For example, with existing methods, a user typically provides an input to perform a single operation.", "When the user wants to perform a different operation, the user needs to navigate through menus, or to provide a different input, to perform a different operation.", "In addition, certain secure operations involve private information (e.g., credit card information, passwords, etc.)", "or restricted features.", "Such secure operations typically require authentication of the user (e.g., using a passcode).", "Thus, it is cumbersome and inefficient to perform multiple operations, including secure operations.", "In the embodiments described below, an improved method for performing operations is achieved by performing multiple operations in response to a single input.", "Non-secure operations (e.g., resetting a display dim timer) are performed in response to a fingerprint input regardless of an identity of the fingerprint (e.g., regardless of whether the fingerprint belongs to an authorized user), whereas secure operations (e.g., revealing private information) are performed in response to the fingerprint input when the fingerprint input includes a fingerprint that matches a pre-registered (e.g., enrolled) fingerprint.", "This method streamlines performing multiple operations in response to a fingerprint input, thereby eliminating the need for extra, separate steps to perform the multiple operations.", "In some embodiments, the device is an electronic device with a separate display (e.g., display 450) and a separate touch-sensitive surface (e.g., touch-sensitive surface 451).", "In some embodiments, the device is portable multifunction device 100, the display is touch screen 112, and the touch-sensitive surface includes tactile output generators 167 on the display (FIG.", "1A).", "The device described below with reference to 8A-8W and 9A-9B includes one or more fingerprint sensors 169.In some embodiments, the one or more fingerprint sensors include one or more integrated fingerprint sensors 359-1 (FIG.", "4B) that are integrated in to the touch-sensitive surface (e.g., separate touch-sensitive surface 451 or touch sensitive display system 112).", "In some embodiments, the one or more fingerprint sensors include separate fingerprint sensors 359-2 (FIG.", "4B) that are separate from the touch-sensitive surface (e.g., separate touch-sensitive surface 451 or touch sensitive display system 112).", "Unless specified otherwise, a fingerprint sensor 169 described below is, optionally, either an integrated fingerprint sensor 359-1 or a separate fingerprint sensor 359-2, depending on the configuration of the hardware and software of the device that includes the fingerprint sensor 169.For convenience of explanation, the embodiments described with reference to FIGS.", "8A-8W and 9A-9B will be discussed with reference to display 450, a separate touch-sensitive surface 451 and a separate fingerprint sensor 359-2, however analogous operations are, optionally, performed on a device with an integrated fingerprint sensor 359-1 in response to detecting the inputs described in FIGS.", "8A-8W on the integrated fingerprint sensor 359-1 while displaying the user interfaces shown in FIGS.", "8A-8B on the display 450.Additionally, analogous operations are, optionally, performed on a device with a touch screen 112 in response to detecting the contacts described in FIGS.", "8A-8W on a fingerprint sensor 169 (e.g., an integrated fingerprint sensor 359-1 or a separate fingerprint sensor 359-2) while displaying the user interfaces shown in FIGS.", "8A-8W on the touch screen 112.FIGS.", "8A-8W illustrate exemplary user interfaces for performing operations based on fingerprints in accordance with some embodiments.", "FIG.", "8A illustrates an exemplary user interface for a shopping web page.", "The exemplary user interface includes a plurality of input fields (e.g., 802-1 through 802-8) and representations of information in respective input fields (e.g., 804).", "The representations of information in the respective input fields are distinct from the information in the respective input fields.", "These representations are sometimes called redacted representations, and the information in these input fields is sometimes called redacted information.", "For example, as illustrated, the redacted representations of information in the respective input fields indicate that the respective input fields contain information, but do not reveal the information in the respective input fields.", "Although redacted information in the respective input fields are represented with solid dots (e.g., a single solid dot representing a respective character in the respective input fields) in FIG.", "8A, redacted information in the respective input fields may be represented using any other characters, shapes, or visual representations that do not directly convey the information in the respective input fields.", "In some implementations, one or more of the input fields in a respective user interface contain non-redacted information, and those input fields show the information in those input fields, while others of the input fields contain redacted information, as represented by redacted representations.", "FIG.", "8A also illustrates a display dim timer 896-1 and a credential-authorization timer 898-1.The display dim timer 896-1 and the credential-authorization timer 898-1 in FIG.", "8A indicate that the display dim timer 896-1 and the credential-authorization timer 898-1 are in respective reset positions.", "In some embodiments, the display dim timer 896-1 is a timer that is used to determine when to dim the display of the device 100.In some embodiments, the credential-authorization timer 898-1 is a timer that is used to determine when enrolled fingerprints are no longer authorized to authenticate a user of the device 100.Although the display dim timer 896-1 and the credential-authorization timer 898-1 are illustrated in FIG.", "8A to describe certain operations of the device 100, the display dim timer 896-1 and the credential-authorization timer 898-1 are not necessarily shown on the touch screen 112.In some embodiments, the display dim timer 896-1 is shown on the touch screen 112.In other embodiments, the display dim timer 896-1 is not shown on the touch screen 112.In some embodiments, the credential-authorization timer 898-1 is shown on the touch screen 112.In other embodiments, the credential-authorization timer 898-1 is not shown on the touch screen 112.FIG.", "8B illustrates the display dim timer 896-2 and the credential-authorization timer 898-2 that indicate that time has elapsed.", "As illustrated in FIG.", "8B, in some embodiments, the display dim timer 896-1 expires faster than the credential-authorization timer 898-1.For example, in some embodiments, the display dim timer 896-1 expires within a minute, and the credential-authorization timer 898-1 expires in 24 or 48 hours.", "In some implementations, the dim timer has an expiration period that is user selectable, for example, to any of a set of predefined dim timer expiration periods, such as 1 minute, 2 minutes, 5 minutes and 10 minutes.", "In some implementations, the credential-authorization timer has a default expiration period (e.g., 48 hours) that can be overridden by the user or by a corporate policy that includes one or more default setting value overrides.", "If overridden, the authorization timer expiration period is set to a shorter period (e.g., 24 hours, 12 hours, 6 hours, 4 hours, or 2 hours) than the default expiration period.", "FIG.", "8C illustrates that further time has elapsed, and the display dim timer 896-3 has expired.", "In accordance with a determination that the display dim timer has expired, the touch screen 112 is automatically dimmed (e.g., a brightness of the touch screen 112 is reduced).", "FIG.", "8C also illustrates that, while the touch screen 112 is dimmed, an input 812 (e.g., a finger contact or a contact with an object) is detected on the fingerprint sensor 169.In some embodiments, in accordance with a determination that the input 812 does not include a fingerprint (e.g., a contact with an object such as a pen), the input 812 is ignored (e.g., no operation is performed in response to the input 812).", "In some embodiments, in accordance with a determination that the input 812 includes a fingerprint, one or more operations are performed.", "FIGS.", "8D-8F illustrate three respective sets of operations that may be performed in response to the input 812 in accordance with a determination that the input 812 includes a fingerprint, in accordance with some embodiments.", "FIG.", "8D illustrates an exemplary set of operations that are performed in response to the input 812 (FIG.", "8C) that includes a fingerprint, in accordance with some embodiments.", "In FIG.", "8D, the display dim timer 896-4 is reset and the touch screen 112 ceases to be dimmed (e.g., the brightness of the touch screen 112 increases to the brightness of the touch screen 112 before dimming).", "In FIG.", "8D, the credential-authorization timer 898-4 is not reset.", "Also in FIG.", "8D, the representations of information (e.g., 804) in respective input fields (e.g., 802-1 through 802-8) remain on the touch screen 112.FIG.", "8E illustrates an alternative set of operations that are performed in response to the input 812 (FIG.", "8C) that includes a fingerprint, in accordance with some embodiments.", "In FIG.", "8E, the display dim timer 896-5 is reset and the touch screen 112 ceases to be dimmer.", "In addition, the representations (sometimes called redacted representations) of information (e.g., 804 in FIG.", "8C) in respective input fields (e.g., 802-1 through 802-8) are replaced with the information (sometimes called non-redacted information) in the respective input fields.", "For example, in FIG.", "8E, the representations of information in respective input fields are replaced with the payment information (e.g., credit card number, expiration date, security code, name on the card, billing address, etc.).", "In FIG.", "8F, the credential-authorization timer 898-5 is not reset.", "FIG.", "8F illustrates yet another alternative set of operations that are performed in response to the input 812 (FIG.", "8C) that includes a fingerprint, in accordance with some embodiments.", "In FIG.", "8F, the display dim timer 896-6 is reset and the touch screen 112 ceases to be dimmer.", "In addition, the representations (sometimes called redacted representations) of information (e.g., 804 in FIG.", "8C) in respective input fields (e.g., 802-1 through 802-8) are replaced with the information (sometimes called non-redacted information) in the respective input fields.", "Furthermore, the credential-authorization timer 898-6 is reset.", "In some embodiments, the respective sets of operations illustrated in FIGS.", "8E-8F are performed in accordance with a determination that the fingerprint in the input 812 matches an enrolled fingerprint.", "However, in some embodiments, the operations illustrated in FIG.", "8D is performed regardless of whether the fingerprint in the input 812 matches an enrolled fingerprint (e.g., in some embodiments, the operations illustrated in FIG.", "8D is performed even when the fingerprint in the input 812 does not match an enrolled fingerprint).", "FIGS.", "8G-8H illustrate operations that are performed while the touch screen 112 is not dimmed, in accordance with some embodiments.", "FIG.", "8G illustrates a user interface that is similar to the user interface shown in FIG.", "8B.", "In FIG.", "8G, the display dim timer 896-7 and the credential-authorization timer 898-7 have not expired.", "FIG.", "8G also illustrates that an input 814 is detected on the fingerprint sensor 169.In some embodiments, in accordance with a determination that the input 814 does not include a fingerprint (e.g., a contact with an object such as a pen), the input 814 is ignored (e.g., no operation is performed in response to the input 814).", "In some embodiments, in accordance with a determination that the input 814 includes a fingerprint, one or more operations are performed.", "FIG.", "8H illustrates that in response to the input 814 that includes a fingerprint, the display dim timer 896-8 is reset.", "In FIG.", "8H, the credential-authorization timer 898-4 is not reset.", "Also in FIG.", "8H, the representations of information (e.g., 804) in respective input fields (e.g., 802-1 through 802-8) remain on the touch screen 112.FIGS.", "8I-8K illustrate operations that are performed before the credential-adjustment timer 898 expires, in accordance with some embodiments.", "FIG.", "8I illustrates a lock screen displayed on the touch screen 112.In FIG.", "8I, the credential-adjustment timer 898-9 has not expired.", "A display dim timer (e.g., 896-8 in FIG.", "8G) is not illustrated in FIG.", "8I for brevity.", "However, a person having ordinary skill in the art would understand that, in some implementations, display dim-timer 896 related operations can be performed from the lock screen.", "For example, in some embodiments, in accordance with a determination that the display dim timer 896 has expired while the touch screen 112 displays a lock screen, the device 100 automatically dims the touch screen 112 while displaying the lock screen on the touch screen 112.In some embodiments, in accordance with a determination that an input that includes a fingerprint is detected on the fingerprint sensor 169, the display dim timer 896 is reset.", "In FIG.", "8I, an input 816 is detected on the fingerprint sensor 169.In some embodiments, in accordance with a determination that the input 816 does not include a fingerprint (e.g., a contact with an object such as a pen), the input 816 is ignored (e.g., no operation is performed in response to the input 816).", "In some embodiments, in accordance with a determination that the input 816 includes a fingerprint, one or more operations are performed.", "FIG.", "8J illustrates an exemplary user interface that is displayed in response to determining that the fingerprint in the input 816 does not match an enrolled fingerprint.", "FIG.", "8J also illustrates that an input 818, distinct from the input 816, is detected on the fingerprint sensor 169.In some embodiments, in accordance with a determination that the input 818 does not include a fingerprint (e.g., a contact with an object such as a pen), the input 818 is ignored (e.g., no operation is performed in response to the input 818).", "In some embodiments, in accordance with a determination that the input 818 includes a fingerprint, one or more operations are performed.", "FIG.", "8K illustrates that, in some embodiments, in accordance with a determination that the fingerprint in the input 818 matches an enrolled fingerprint, the device 100 is unlocked.", "In some embodiments, unlocking the device 100 includes displaying a home screen.", "FIGS.", "8L-8M illustrate operations that are performed while the credential-authorization timer 898 is expired.", "FIG.", "8L illustrates a lock screen displayed on the touch screen 112.In FIG.", "8L, the credential-adjustment timer 898-9 is expired.", "FIG.", "8L also illustrates that an input 820 is detected on the fingerprint sensor 169.In some embodiments, in accordance with a determination that the input 820 does not include a fingerprint (e.g., a contact with an object such as a pen), the input 820 is ignored (e.g., no operation is performed in response to the input 820).", "In some embodiments, in accordance with a determination that the input 820 includes a fingerprint, one or more operations are performed.", "FIG.", "8M illustrates that a passcode screen (shown in FIG.", "8M) is displayed on the touch screen 112 in response to the input 820 (FIG.", "8L), in accordance with some embodiments.", "In some embodiments, even if the fingerprint in the input 820 (FIG.", "8L) matches an enrolled fingerprint, the passcode screen is displayed in accordance with a determination that the input 820 (FIG.", "8L) has been received while the credential-authorization timer 898 is expired.", "In some embodiments, the passcode screen is displayed in accordance with a determination that an input that includes a fingerprint has been received while the credential-authorization timer 898 is expired, regardless of whether the fingerprint in the input matches an enrolled fingerprint.", "FIGS.", "8N-8O illustrate exemplary operations for providing access to restricted features, in accordance with some embodiments.", "FIG.", "8N illustrates a user interface that includes one or more selectable user interface objects (e.g., buttons labeled “Network Settings,” “Bluetooth,” and “Sounds”).", "Compared to FIG.", "8O, one or more selectable user interface objects (e.g., a button labeled “Credential Manager” 806, FIG.", "8O) are not displayed on the touch screen 112.FIG.", "8N also illustrates that an input 822 is detected on the fingerprint sensor 169.In some embodiments, in accordance with a determination that the input 822 does not include a fingerprint (e.g., a contact with an object such as a pen), the input 822 is ignored (e.g., no operation is performed in response to the input 822).", "In some embodiments, in accordance with a determination that the input 822 includes a fingerprint, one or more operations are performed.", "FIG.", "8O illustrates that in accordance with a determination that the fingerprint in the input 822 matches an enrolled fingerprint, a selectable user interface object 806 is displayed on the touch screen 112.FIG.", "8O also illustrates that a touch input 824 is detected on the touch screen 112 at a location that corresponds to the selectable user interface object 806.FIG.", "8P illustrates an exemplary user interface (e.g., a credential manager user interface) that is displayed in response to detecting the touch input 824 (FIG.", "8O) at a location that corresponds to the selectable user interface object 806.The exemplary user interface in FIG.", "8P includes a plurality of fields and representations of information in the respective fields.", "FIG.", "8P also illustrates a unauthorized-attempt counter 894-1 that counts a number of unauthorized attempts to perform one or more predefined secure operations (e.g., revealing private information or providing access to restricted features).", "Although the unauthorized-attempt counter 894-1 is illustrated in FIGS.", "8P-8V to describe certain operations of the device 100, the unauthorized-attempt counter 894-1 is not necessarily shown on the touch screen 112.In some embodiments, the unauthorized-attempt counter 894-1 is shown on the touch screen 112.In other embodiments, the unauthorized-attempt counter 894-1 is not shown on the touch screen 112.FIG.", "8P illustrates that an input 826 is detected on the fingerprint sensor 169.In some embodiments, in accordance with a determination that the input 826 does not include a fingerprint (e.g., a contact with an object such as a pen), the input 826 is ignored (e.g., no operation is performed in response to the input 826).", "In some embodiments, in accordance with a determination that the input 826 includes a fingerprint, one or more operations are performed.", "In some embodiments, in accordance with a determination that the fingerprint in the input 826 does not match an enrolled fingerprint, no operation is performed.", "FIG.", "8Q illustrates that, in accordance with a determination that the fingerprint in the input 826 does not match an enrolled fingerprint, the number of unauthorized attempts to perform one or more predefined secure operations in the unauthorized-attempt counter 894-1 increases (e.g., from zero to one), in some embodiments.", "In some embodiments, as shown in FIG.", "8Q, the representations (sometimes called redacted representations) of information in the respective fields remain on the touch screen 112.FIG.", "8Q illustrates that the input 826 (FIG.", "8P) is no longer detected on the fingerprint sensor 169.In some embodiments, the number of unauthorized attempts to perform one or more predefined secure operations in the unauthorized-attempt counter 894-1 increases in response to detecting liftoff of the input 826 (FIG.", "8P) from the fingerprint sensor 169 and in accordance with a determination that the fingerprint in the input 826 (FIG.", "8P) does not match an enrolled fingerprint.", "FIG.", "8R illustrates that an input 828 is detected on the fingerprint sensor 169.In some embodiments, in accordance with a determination that the input 828 does not include a fingerprint (e.g., a contact with an object such as a pen), the input 828 is ignored (e.g., no operation is performed in response to the input 828).", "In some embodiments, in accordance with a determination that the input 828 includes a fingerprint, one or more operations are performed.", "In some embodiments, in accordance with a determination that the fingerprint in the input 828 does not match an enrolled fingerprint, no operation is performed.", "FIG.", "8S illustrates that, in accordance with a determination that the fingerprint in the input 828 does not match an enrolled fingerprint, the number of unauthorized attempts to perform one or more predefined secure operations in the unauthorized-attempt counter 894-3 increases (e.g., from one to two), in some embodiments.", "In some embodiments, as shown in FIG.", "8S, the representations of information in the respective fields remain on the touch screen 112.In FIGS.", "8S-8U, we will assume that the number of unauthorized attempts in the unauthorized-attempt counter 894-3 satisfies (e.g., matches or exceeds) a predefined number of unauthorized attempts (e.g., two, three, four or five).", "FIG.", "8S also illustrates that the input 828 (FIG.", "8R) is no longer detected on the fingerprint sensor 169.In some embodiments, the number of unauthorized attempts to perform one or more predefined secure operations in the unauthorized-attempt counter 894-3 increases in response to detecting liftoff of the input 828 (FIG.", "8R) from the fingerprint sensor 169 and in accordance with a determination that the fingerprint in the input 828 (FIG.", "8R) does not match an enrolled fingerprint.", "FIG.", "8T illustrates that an input 830 is detected on the fingerprint sensor 169.In some embodiments, in accordance with a determination that the input 830 does not include a fingerprint (e.g., a contact with an object such as a pen), the input 830 is ignored (e.g., no operation is performed in response to the input 830).", "In some embodiments, in accordance with a determination that the input 830 includes a fingerprint, one or more operations are performed.", "In some embodiments, in accordance with a determination that the fingerprint in the input 830 does not match an enrolled fingerprint, no operation is performed.", "FIG.", "8U illustrates that even if the fingerprint in the input 830 matches an enrolled fingerprint, the representations (sometimes called redacted representations) of information in the respective fields remain on the touch screen 112 (e.g., the information in the respective fields is not revealed).", "In some embodiments, the number of unauthorized attempts in the unauthorized-attempt counter 894-3 does not increase once the number of unauthorized attempts in the unauthorized-attempt counter 894-3 satisfies the predefined number of unauthorized attempts (e.g., two) as illustrated in FIG.", "8U.", "In some embodiments, the number of unauthorized attempts in the unauthorized-attempt counter 894-3 increases for a fingerprint in a respective input that does not match an enrolled fingerprint regardless of whether the number of unauthorized attempts in the unauthorized-attempt counter 894-3 satisfies the predefined number of unauthorized attempts.", "In some embodiments, once the number of unauthorized attempts in the unauthorized-attempt counter 894-3 satisfies the predefined number of unauthorized attempts, the unauthorized-attempt counter 894-3 is reset by providing a correct passcode on a passcode screen (e.g., FIG.", "8M).", "FIGS.", "8V-8W illustrate operations performed while the number of unauthorized attempts in the unauthorized-attempt counter 894-3 does not satisfy the predefined number of unauthorized attempts.", "FIG.", "8V illustrates that an input 832 is detected on the fingerprint sensor 169.In some embodiments, in accordance with a determination that the input 832 does not include a fingerprint (e.g., a contact with an object such as a pen), the input 832 is ignored (e.g., no operation is performed in response to the input 832).", "In some embodiments, in accordance with a determination that the input 832 includes a fingerprint, one or more operations are performed.", "In some embodiments, in accordance with a determination that the fingerprint in the input 832 does not match an enrolled fingerprint, no operation is performed.", "FIG.", "8W illustrates that in accordance with a determination that the fingerprint in the input 832 matches an enrolled fingerprint, the representations (sometimes called redacted representations) of information in the respective fields are replaced with the information (sometimes called non-redacted or unredacted information) in the respective fields.", "For example, as shown in FIG.", "8W, the representations of information in the respective fields are replaced with one or more sets of usernames and passwords (sometimes called non-redacted or unredacted usernames and passwords).", "In some embodiments, while the number of unauthorized attempts in the unauthorized-attempt counter 894-4 (FIG.", "8V) does not satisfy the predefined number of unauthorized attempts, in accordance with a determination that the fingerprint in the input 832 matches an enrolled fingerprint, the unauthorized-attempt counter 894-4 (FIG.", "8V) is reset.", "FIGS.", "9A-9B are flow diagrams illustrating a method 900 of performing operations based on fingerprints in accordance with some embodiments.", "The method 900 is performed at an electronic device (e.g., device 300, FIG.", "3, or portable multifunction device 100, FIG.", "1A) with a display and a touch-sensitive surface.", "In some embodiments, the display is a touch screen display and the touch-sensitive surface is on the display.", "In some embodiments, the display is separate from the touch-sensitive surface.", "Some operations in method 900 are, optionally, combined and/or the order of some operations is, optionally, changed.", "As described below, the method 900 provides an intuitive way to perform operations based on fingerprints.", "The method reduces the cognitive burden on a user when performing operations based on fingerprints, thereby creating a more efficient human-machine interface.", "For battery-operated electronic devices, enabling a user to perform operations based on fingerprints faster and more efficiently conserves power and increases the time between battery charges.", "The device detects (902), with the fingerprint sensor, a first input.", "For example, as illustrated in FIG.", "8C, an input 812 is detected on the fingerprint sensor 169.In response to detecting the first input, the device determines (904) whether the first input includes a fingerprint.", "In accordance with a determination that the first input includes a fingerprint, the device performs (906) a first operation based on the presence of the fingerprint without regard to an identity of the fingerprint.", "In some embodiments, the first operation includes resetting a display dim timer.", "For example, as illustrated in FIG.", "8E, in accordance with a determination that the first input includes a fingerprint, the display dim timer 896-5 is reset.", "Typically, resetting the display dim timer has an effect that the brightness of the display is not automatically dimmed, because the dim timer has not expired (is not in an expired state).", "Typically, as long as the fingerprint continues to be detected on the fingerprint sensor, the brightness of the display is not automatically dimmed.", "In some embodiments, the device includes (908) a display.", "The device also includes a display dim timer (e.g., 896-1 in FIG.", "8A) that starts from a dim timer starting value (e.g., zero seconds).", "The device automatically dims the display in accordance with a determination that the display dim timer has expired (e.g., the display dim timer reaches a predefined expiration value, such as 60 seconds, 120 seconds, etc.)", "In some embodiments, the display dim timer stores time elapsed since the display dim timer was reset.", "For example, when one second has elapsed since the display dim timer was reset, the display dim timer stores one second.", "When two seconds have elapsed since the display dim timer was reset, the display dim timer stores two seconds.", "In some embodiments, the first operation includes resetting the display dim timer to the dim timer starting value.", "In another example, the dim timer is a count down timer, the dim timer expiration value is zero seconds, and the dim starting value is value such as 60 seconds, 120 second, 300 seconds, etc.", "In this example, the display is not dimmed so long as the dim timer has a non-zero value.", "In some embodiments, the device collects information about a fingerprint in contact with the fingerprint sensor at predetermined intervals that are shorter than the amount of time that it takes for the dim timer to expire, so that while the fingerprint is maintained on the fingerprint sensor, the device will repeatedly detect the fingerprint and reset the dim timer and as a result, in such a situation, the brightness of the display is not automatically dimmed as long as the fingerprint continues to be detected on the fingerprint sensor.", "In accordance with a determination that the fingerprint in the first input matches an enrolled fingerprint, the device conditionally performs (910) a second operation based on the enrolled fingerprint.", "For example.", "as illustrated in FIG.", "8E, the device reveals private information (e.g., credit card information) in accordance with a determination that the fingerprint in the input 812 (FIG.", "8C) matches an enrolled fingerprint.", "In some embodiments, conditionally performing the second operation includes performing the second operation in accordance with a determination that the second operation is not prevented.", "In some embodiments, conditionally performing the second operation includes forgoing the second operation in accordance with a determination that the second operation is prevented.", "In some implementations, the second operation is prevented in accordance with a determination that a credential-authorization timer 898 has expired.", "In some embodiments, the second operation includes (912) one or more of: revealing private information (e.g., revealing the credit card information as illustrated in FIG.", "8E) and providing access to restricted features (e.g., as illustrated in FIG.", "8O, displaying a selectable user interface object 806, which, when selected, initiates a display of a user interface with restricted features, such as a credential manager features).", "In some embodiments, in response to detecting the first input, in accordance with the determination that the first input includes the fingerprint and a determination that the fingerprint in the first input does not match an enrolled fingerprint, the device forgoes (914) performance of the second operation.", "For example, as illustrated in FIGS.", "8G-8H, in response to detecting the input 814 (FIG.", "8G) and in accordance with a determination that the input 814 includes a fingerprint and a determination that the fingerprint in the input 814 does not match an enrolled fingerprint, the device forgoes performance of the second operation (e.g., private information, such as credit card information, is not revealed in FIG.", "8H).", "In some embodiments, in response to detecting the first input, in accordance with the determination that the first input includes the fingerprint and a determination that the fingerprint in the first input does not match an enrolled fingerprint, the device performs (916) the first operation without performing the second operation.", "For example, as illustrated in FIGS.", "8G-8H, in response to detecting the input 814 (FIG.", "8G) and in accordance with a determination that the input 814 includes a fingerprint and a determination that the fingerprint in the input 814 does not match an enrolled fingerprint, the device performs the first operation (e.g., resetting the display dim timer 896-8 in FIG.", "8H) without performing the second operation (e.g., private information, such as credit card information, is not revealed in FIG.", "8H).", "In some embodiments, the first operation and the second operation are both performed (918) in accordance with a determination that the first input includes a fingerprint that matches an enrolled fingerprint.", "For example, as illustrated in FIGS.", "8C and 8E, in accordance with a determination that the input 812 (FIG.", "8C) includes a fingerprint that matches an enrolled fingerprint, the first operation (e.g., resetting the display dim timer 896-5) and the second operation (e.g., revealing private information, such as credit card information, as shown in FIG.", "8E) are both performed.", "In some embodiments, in accordance with a determination that the first input includes a fingerprint that matches an enrolled fingerprint, the device also performs (920) a third operation, distinct from the second operation, based on the enrolled fingerprint.", "For example, as illustrated in FIGS.", "8C and 8F, in accordance with a determination that the input 812 (FIG.", "8C) includes a fingerprint that matches an enrolled fingerprint, the device performs a third operation (e.g., resetting the credential-authorization timer 898-6 in FIG.", "8F).", "In some embodiments, the device includes (922) a credential-authorization timer (e.g., a timer that measures an amount of time that enrolled fingerprints authorized to use: a device unlock credential such as a passcode, or a purchasing credential such as a credit card number or a password for a store account that is linked to a credit card number or other payment source) that starts from an authorization timer starting value (e.g., zero).", "In some embodiments, the credential-authorization timer stores time elapsed since the credential-authorization timer was reset.", "For example, when one hour has elapsed since the credential-authorization timer was reset, the credential-authorization timer stores one hour.", "When two hours have elapsed since the credential-authorization timer was reset, the credential-authorization timer stores two hours.", "In some embodiments, the device prevents unlocking the device with a fingerprint (with a fingerprint matching an enrolled fingerprint) after the credential-authorization timer expires (e.g., reaches a predefined expiration value, such as 12 hours, 24 hours, or 48 hours).", "In another example, the credential-authorization timer is a count down timer, the credential-authorization timer expiration value is zero seconds, and the credential-authorization timer starting value is (or corresponds to) the authorization timer expiration period, such as any of the authorization timer expiration periods listed elsewhere in this document.", "In this example, the device does not prevent unlocking the device (with a fingerprint matching an enrolled fingerprint) so long as the credential-authorization timer has a non-zero value.", "In some embodiments, preventing the unlocking of the device with a fingerprint includes disabling the unlocking of the device with a fingerprint.", "For example, as illustrated in FIGS.", "8L-8M, in accordance with a determination that the credential-authorized timer 898-12 (FIG.", "8L) has expired, the device prevents unlocking the device even though a fingerprint in the input 820 matches an enrolled fingerprint.", "In some embodiments, in response to the input 820, the device displays a passcode screen (FIG.", "8M) instead of unlocking the device.", "In comparison, in some embodiments, as illustrated in FIGS.", "8J-8K, in accordance with a determination that the credential-authorization timer 898-10 (FIG.", "8J) has not expired, the device unlocks in response to a fingerprint in the input 818 that matches an enrolled fingerprint (e.g., ceases to display an unlock screen illustrated in FIG.", "8J and displays a home screen illustrated in FIG.", "8K).", "In some embodiments, the third operation includes resetting the credential-authorization timer to the authorization timer starting value.", "For example, as illustrated in FIGS.", "8C and 8F, in accordance with a determination that the input 812 (FIG.", "8C) includes a fingerprint that matches an enrolled fingerprint, the device performs a third operation (e.g., resetting the credential-authorization timer 898-5 in FIG.", "8F).", "In some embodiments, the first input includes (924) a respective fingerprint on the fingerprint sensor.", "The device detects liftoff of the respective fingerprint from the fingerprint sensor.", "In response to detecting liftoff of the fingerprint from the fingerprint sensor and in accordance with a determination that the respective fingerprint does not match an enrolled fingerprint, the device increments a count of unauthorized attempts to perform the second operation (e.g., unauthorized attempts to unlock the device).", "For example, as illustrated in FIGS.", "8P and 8Q, in response to detecting liftoff of the input 826 (FIG.", "8P) from the fingerprint sensor 169 (FIG.", "8Q) and in accordance with a determination that a fingerprint in the input 826 does not match an enrolled fingerprint, the device increases a count of unauthorized attempts to perform the second operation (e.g., the count in the unauthorized-attempt counter 894-2) from zero to one.", "In some embodiments, the count of unauthorized attempts is only incremented upon detecting a distinct fingerprint gesture that includes touchdown and liftoff of a fingerprint from the fingerprint sensor.", "As a result, a long continuous fingerprint gesture is only counted as a single attempt to perform the second operation.", "In some embodiments, subsequent to incrementing the count of unauthorized attempts to perform the second operation, the device determines (926) whether fingerprint-disable criteria have been met.", "The fingerprint-disable criteria include a criterion that is met when the count of unauthorized attempts to perform the second operation satisfies a predefined number of unauthorized attempts to perform the second operation.", "In some embodiments, the count of unauthorized attempts to perform in the second operation is deemed to satisfy a predefined number of unauthorized attempts to perform the second operation when the count of unauthorized attempts to perform the second operation matches the predefined number of unauthorized attempts to perform the second operation.", "For example, when the predefined number of unauthorized attempts to perform the second operation is set to two, and the count of unauthorized attempts to perform the second operation in the unauthorized-attempt counter 894-3 (FIG.", "8T) is two, the count of unauthorized attempts satisfies the predefined number of unauthorized attempts to perform the second operation.", "In some embodiments, the count of unauthorized attempts to perform the second operation is deemed to satisfy a predefined number of unauthorized attempts to perform the second operation when the count of unauthorized attempts to perform the second operation exceeds the predefined number of unauthorized attempts to perform the second operation.", "In some embodiments, in accordance with a determination that the fingerprint-disable criteria have been met, the device prevents the second operation from being performed based on a fingerprint (e.g., by disabling the fingerprint sensor or by ignoring a fingerprint detected by the fingerprint sensor that matches a previously enrolled fingerprint).", "For example, as illustrated in FIGS.", "8T-8U, in accordance with a determination that the fingerprint-disable criteria have been met (e.g., the count of unauthorized attempts to perform the second operation satisfies a predefined number of unauthorized attempts to perform the second operation), the device prevents the second operation (e.g., revealing private information such as usernames and passwords) from being performed in response to a fingerprint in an input 830 that matches an enrolled fingerprint (e.g., the representations of private information are maintained on the touch screen 112 in FIG.", "8U and private information is not displayed on the touch screen 112 in FIG.", "8U).", "In some embodiments, the first operation is performed (928) while detecting the presence of a fingerprint on the fingerprint sensor, and the second operation is performed in response to detecting liftoff of a fingerprint that matches a previously enrolled fingerprint from the fingerprint sensor.", "For example, in some embodiments, the first operation (e.g., resetting the display dim timer 896-3 in FIG.", "8C) is performed while detecting the input 812 (FIG.", "8C) that includes a fingerprint on the fingerprint sensor 169 (FIG.", "8C).", "In comparison, in some embodiments, the second operation (e.g., revealing private information such as credit card information) is performed only after detecting liftoff of the input 812 (FIG.", "8C) from the fingerprint sensor 169 (FIG.", "8E).", "It should be understood that the particular order in which the operations in FIGS.", "9A-9B have been described is merely exemplary and is not intended to indicate that the described order is the only order in which the operations could be performed.", "One of ordinary skill in the art would recognize various ways to reorder the operations described herein.", "For example, in some embodiments, the device detects, with the fingerprint sensor, a first input.", "In response to detecting the first input, the device determines whether the first input includes a fingerprint; and, in accordance with a determination that the first input includes a fingerprint, performs a first operation based on the presence of the fingerprint without regard to an identity of the fingerprint; and, in accordance with a determination that the fingerprint in the first input matches an enrolled fingerprint, performs a second operation based on the enrolled fingerprint.", "Additionally, it should be noted that details of other processes described herein with respect to other methods described herein (e.g., those listed in the “Description of Embodiments” section above) are also applicable in an analogous manner to method 900 described above with respect to FIGS.", "9A-9B.", "For example, the inputs, operations, and credentials described above with reference to method 900 optionally have one or more of the characteristics of the inputs, operations, and credentials described herein with reference to other methods described herein (e.g., those listed in the “Description of Embodiments” section above).", "For brevity, these details are not repeated here.", "In accordance with some embodiments, FIG.", "10 shows a functional block diagram of an electronic device 1000 configured in accordance with the principles of the various described embodiments.", "The functional blocks of the device are, optionally, implemented by hardware, software, or a combination of hardware and software to carry out the principles of the various described embodiments.", "It is understood by persons of skill in the art that the functional blocks described in FIG.", "10 are, optionally, combined or separated into sub-blocks to implement the principles of the various described embodiments.", "Therefore, the description herein optionally supports any possible combination or separation or further definition of the functional blocks described herein.", "As shown in FIG.", "10, an electronic device 1000 includes a fingerprint sensor unit 1006 configured to detect a first input; and a processing unit 1008 coupled to the fingerprint sensor unit 1006.In some embodiments, the electronic device 1000 includes a display unit 1002 coupled to the processing unit 1008 and configured to display a graphical user interface.", "In some embodiments, the display unit 1002 is coupled to the fingerprint sensor unit 1006.In some embodiments, the electronic device 1000 includes a touch-sensitive surface unit 1004 coupled to the processing unit 1008 and configured to receive touch inputs.", "In some embodiments, the processing unit 1008 includes a determining unit 1010, a first operation performing unit 1012, a second operation performing unit 1014, a third operation performing unit 1016, a credential-authorization timer unit 1018, a preventing unit 1020, a resetting unit 1022, a display dim timer unit 1024, a dimming unit 1026, a private information revealing unit 1028, an access providing unit 1030, and an incrementing unit 1032.The processing unit 1008 is configured to, in response to detecting the first input, determine whether the first input includes a fingerprint (e.g., with the determining unit 1010).", "The processing unit 1008 is also configured to, in accordance with a determination that the first input includes a fingerprint, perform a first operation based on the presence of the fingerprint without regard to an identity of the fingerprint (e.g., with the first operation performing unit 1012).", "The processing unit 1008 is further configured to, in accordance with a determination that the fingerprint in the first input matches an enrolled fingerprint (e.g., with the determining unit 1010), conditionally perform a second operation based on the enrolled fingerprint (e.g., with the second operation performing unit 1014).", "In some embodiments, the processing unit 1008 is configured to, in response to detecting the first input, in accordance with the determination that the first input includes the fingerprint and a determination that the fingerprint in the first input does not match an enrolled fingerprint, forgo performance of the second operation (e.g., with the preventing unit 1020).", "In some embodiments, the processing unit 1008 is configured to, in response to detecting the first input, in accordance with the determination that the first input includes the fingerprint and a determination that the fingerprint in the first input does not match an enrolled fingerprint (e.g., with the determining unit 1010), perform the first operation (e.g., with the first operation performing unit 1012) without performing the second operation.", "In some embodiments, the first operation and the second operation are both performed (e.g., with the first operation performing unit 1012 and the second operation performing unit 1014) in accordance with a determination that the first input includes a fingerprint that matches an enrolled fingerprint (e.g., with the determining unit 1010).", "In some embodiments, the processing unit 1008 is configured to, in accordance with a determination that the first input includes a fingerprint that matches an enrolled fingerprint, perform a third operation, distinct from the second operation, based on the enrolled fingerprint (e.g., with the third operation performing unit 1016).", "In some embodiments, the device includes a credential-authorization timer unit 1018 that starts from an authorization timer starting value.", "The processing unit 1008 is configured to prevent unlocking the device with a fingerprint (e.g., with the preventing unit 1020) after the credential-authorization timer unit 1018 expires.", "The third operation includes resetting the credential-authorization timer unit 1018 to the authorization timer starting value (e.g., with the resetting unit 1022).", "In some embodiments, the device includes the display unit 1002 coupled to the processing unit 1008.The device includes a display dim timer unit 1024 that starts from a dim timer starting value.", "The processing unit 1008 is configured to automatically enable dimming of the display unit 1002 (e.g., with the dimming unit 1026) in accordance with a determination that the display dim timer unit 1024 has expired (e.g., with the determining unit 1010).", "The first operation includes resetting the display dim timer unit 1024 to the dim timer starting value (e.g., with the resetting unit 1022).", "In some embodiments, the second operation includes one or more of: revealing private information (e.g., with the private information revealing unit 1028) and providing access to restricted features (e.g., with the access providing unit 1030).", "In some embodiments, the first input includes a respective fingerprint on the fingerprint sensor unit 1006.The fingerprint sensor unit 1006 is configured to detect liftoff of the respective fingerprint from the fingerprint sensor unit 1006 and the processing unit 1008 is configured to, in response to detecting liftoff of the fingerprint from the fingerprint sensor unit 1006 and in accordance with a determination that the respective fingerprint does not match an enrolled fingerprint (e.g., with the determining unit 1010), increment a count of unauthorized attempts to perform the second operation (e.g., with the incrementing unit 1032).", "In some embodiments, the processing unit 1008 is configured to, subsequent to incrementing the count of unauthorized attempts to perform the second operation, determine whether fingerprint-disable criteria have been met (e.g., with the determining unit 1010).", "The fingerprint-disable criteria includes a criterion that is met when the count of unauthorized attempts to perform the second operation satisfies a predefined number of unauthorized attempts to perform the second operation.", "In accordance with a determination that fingerprint-disable criteria have been met (e.g., with the determining unit 1010), the processing unit 1008 is configured to prevent the second operation from being performed based on a fingerprint (e.g., with the preventing unit 1020 and/or the second operation performing unit 1014).", "In some embodiments, the first operation is performed (e.g., with the first operation performing unit 1012) while detecting the presence of a fingerprint on the fingerprint sensor unit 1006; and the second operation is performed (e.g., with the second operation performing unit 1014) in response to detecting liftoff of a fingerprint that matches a previously enrolled fingerprint from the fingerprint sensor unit 1006.The operations in the information processing methods described above are, optionally implemented by running one or more functional modules in information processing apparatus such as general purpose processors (e.g., as described above with respect to FIGS.", "1A and 3) or application specific chips.", "The operations described above with reference to FIGS.", "9A-9B are, optionally, implemented by components depicted in FIGS.", "1A-1B or FIG.", "10.For example, detection operation 902, first operation performing operation 906, and second operation performing operation 910 are, optionally, implemented by event sorter 170, event recognizer 180, and event handler 190.Event monitor 171 in event sorter 170 detects a contact on touch-sensitive display 112, and event dispatcher module 174 delivers the event information to application 136-1.A respective event recognizer 180 of application 136-1 compares the event information to respective event definitions 186, and determines whether a first contact at a first location on the touch-sensitive surface corresponds to a predefined event or sub-event, such as selection of an object on a user interface.", "When a respective predefined event or sub-event is detected, event recognizer 180 activates an event handler 190 associated with the detection of the event or sub-event.", "Event handler 190 optionally utilizes or calls data updater 176 or object updater 177 to update the application internal state 192.In some embodiments, event handler 190 accesses a respective GUI updater 178 to update what is displayed by the application.", "Similarly, it would be clear to a person having ordinary skill in the art how other processes can be implemented based on the components depicted in FIGS.", "1A-1B.", "Automatically Populating Credential Fields and Revealing Redacted Credentials Many uses of modern electronic devices require users to provide credentials in order to access certain information and/or services.", "For example, e-commerce websites or applications often require a user to enter a credit card number, billing address, and shipping address in order to make a purchase.", "As another example, users are often required to enter a user ID and/or password before access to a secure service or other secure information is granted (e.g., an email website or application, a social network, etc.).", "Because users are required to provide credentials so frequently when using electronic devices, it is possible to store credentials in memory of such devices so that they can be inserted into credential fields without requiring manual entry by the user.", "However, this presents several security and privacy risks.", "For example, an unauthorized user may be able pick up a device that does not belong to them and make purchases using stored credit card information, or gain access to personal and/or sensitive data, applications, websites, or the like.", "Moreover, in order to protect the privacy and/or security of credentials, they may be displayed in redacted form so that they cannot be read or copied.", "However, this makes it difficult for users to review the credentials to confirm that they were entered correctly, or to review and/or edit stored credentials that are typically only displayed in redacted form (e.g., as may be the case in a credential manager interface with which a user can enter, edit, and otherwise manage credentials stored on a device).", "In embodiments described below, fingerprint recognition is used to provide authorization to access credentials, and, more particularly, to provide authorization to populate credential fields and/or display non-redacted versions of credentials to a user.", "For example, if a user navigates to a form with credential fields (e.g., for a credit card number, a billing address, etc.", "), the user can provide a fingerprint input by placing a finger on a fingerprint sensor.", "If the fingerprint detected on the fingerprint sensor matches a previously registered fingerprint of the user (and, optionally, if other conditions are satisfied) the credential fields will be automatically populated with stored credentials associated with the user.", "This way, manual entry of credentials, which is time consuming and can be prone to text input errors, is avoided.", "As another example, if redacted credentials are displayed (e.g., in a webpage or a credential manager interface), the user can provide a fingerprint input in order to cause the credentials to be displayed in a non-redacted (i.e., human readable) form.", "Accordingly, credentials can be accessed for viewing and/or input into credential fields quickly and intuitively, while also preventing unauthorized access to such credentials.", "In some embodiments, the device is an electronic device with a separate display (e.g., display 450) and a separate touch-sensitive surface (e.g., touch-sensitive surface 451).", "In some embodiments, the device is portable multifunction device 100, the display is touch screen 112, and the touch-sensitive surface includes tactile output generators 167 on the display (FIG.", "1A).", "The device described below with reference to 11A-11D, 14A-14C, 12A-12B, and 15A-15B includes one or more fingerprint sensors 169.In some embodiments, the one or more fingerprint sensors include one or more integrated fingerprint sensors 359-1 (FIG.", "4B) that are integrated in to the touch-sensitive surface (e.g., separate touch-sensitive surface 451 or touch sensitive display system 112).", "In some embodiments, the one or more fingerprint sensors include separate fingerprint sensors 359-2 (FIG.", "4B) that are separate from the touch-sensitive surface (e.g., separate touch-sensitive surface 451 or touch sensitive display system 112).", "Unless specified otherwise, a fingerprint sensor 169 described below is, optionally, either an integrated fingerprint sensor 359-1 or a separate fingerprint sensor 359-2, depending on the configuration of the hardware and software of the device that includes the fingerprint sensor 169.For convenience of explanation, the embodiments described with reference to FIGS.", "11A-11D, 14A-14C, 12A-12B, and 15A-15B will be discussed with reference to a device with a touch screen 112 and a separate fingerprint sensor 359-2, however analogous operations are, optionally, performed on a device with an integrated fingerprint sensor 359-1 in response to detecting the inputs described in FIGS.", "11A-11D and 14A-14C on the integrated fingerprint sensor 359-1 while displaying the user interfaces shown in FIGS.", "11A-11D and 14A-14C on the display 450.Additionally, analogous operations are, optionally, performed on a device with a display 450 and a separate touch-sensitive surface 451 instead of a touch screen 112 in response to detecting the contacts described in FIGS.", "11A-11D and 14A-14C on a fingerprint sensor 169 (e.g., an integrated fingerprint sensor 359-1 or a separate fingerprint sensor 359-2) and/or the separate touch-sensitive surface 451 while displaying the user interfaces shown in FIGS.", "11A-11D and 14A-14C on the display 450; in such embodiments, the contacts shown in FIGS.", "11A-11D and 14A-14C optionally represent both a focus selector that corresponds to a location on the display 450, and a contact that corresponds to a location of a contact or gesture performed on the separate touch-sensitive surface (e.g., touch-sensitive surface 451), where the focus selector is, optionally: a respective contact, a representative point corresponding to a contact (e.g., a centroid of a respective contact or a point associated with a respective contact), or a centroid of two or more contacts detected on the touch screen 112 and is, optionally, replaced with a displayed cursor.", "FIG.", "11A illustrates an exemplary user interface that is displayed on a display of a portable multi-function device 100, where the user interface displays a form 1101 with fields 1102 (1102-1, .", ".", ".", ", 1102-8) corresponding to a plurality of credentials.", "The fields 1102 illustrated in FIG.", "11A correspond to the types of fields that are sometimes present in a “checkout” form of an e-commerce website or application, including credit card information fields (e.g., credit card number field 1102-1, expiration date field 1102-2, etc.)", "and billing address information fields (e.g., street field 1102-5, city field 1102-6, etc.).", "The fields 1102 displayed in form 1101 are merely exemplary, and more or fewer fields may be displayed in various embodiments.", "Moreover, other fields, including other types of fields that are not shown in FIG.", "11A, may be included instead of or in addition to those shown.", "As shown in FIG.", "11A, device 100 detects a finger input 1110 on fingerprint sensor 169 while displaying form 1101.In some embodiments, finger input 1110 corresponds to a request to automatically fill in the fields in form 1101.For example, in some embodiments, when a form with credential fields is displayed by device 100, detection of an authorized fingerprint on fingerprint sensor 169 will cause the device 100 to populate the fields with stored credentials.", "On the other hand, as described below, if an unauthorized fingerprint is detected on fingerprint sensor 169, the fields will not be populated with stored credentials.", "FIG.", "11B illustrates form 1101 after fields 1102 have been populated with credentials (e.g., after it has been determined that the fingerprint 1110 is associated with a user who is authorized to use the credentials).", "As shown in FIG.", "11B, the credentials are displayed in redacted form so that they are unreadable to a user of the device.", "In this example, the redacted credentials are represented as sequences of dots.", "However, one of ordinary skill in the art would recognize that other redaction techniques may also be implemented in various embodiments (e.g., any removal, replacement or obscuration of the characters so that the credentials are unreadable by a user of the device).", "In some embodiments, credentials that are automatically populated into credential fields are redacted by default.", "In some embodiments, one or more of the automatically inserted credentials are displayed in non-redacted or partially redacted form (i.e., including redacted and non-redacted portions), instead of the redacted form illustrated in FIG.", "11B.", "For example, in some embodiments, the last four digits of the credit card credential 1104 are displayed in human readable form (not shown).", "In some embodiments, other credentials are displayed in partially redacted or non-redacted form, such as a billing address, a name on a credit card, etc.", "In some embodiments where multiple credential fields are displayed, any combination of redacted, partially redacted, and non-redacted credentials may be displayed.", "For example, in some embodiments, a credit card number credential is displayed in partially redacted form, an expiration date and credit card security code are displayed in redacted form, and a billing address is displayed in non-redacted form.", "In some embodiments, whether a credential is displayed in redacted, partially redacted, or non-redacted form is based on a sensitivity and/or security level associated with that credential.", "For example, credit card numbers, bank account numbers, and the like may be associated with a higher sensitivity and/or security level than usernames and mailing addresses.", "As described above, FIG.", "11B illustrates form 1101 after it has been determined that the fingerprint 1110 is associated with a user who is authorized to use the credentials, and after device 100 has filled in form 1101 with the credentials (e.g., the fields 1102 have been populated with the credentials).", "If, on the other hand, it is determined that fingerprint 1110 is not associated with a user who is authorized to use the credentials, the device forgoes filling in the form 1101 with the credentials (not shown).", "In some embodiments, if a finger input (e.g., finger input 1110) is detected, but the fingerprint does not match those of an authorized user, device 100 issues a prompt indicating that the request to automatically populate the credential fields is denied.", "In some embodiments, once the form 1101 has been filled in, an additional finger input can be used to cause the credentials to be displayed in non-redacted form, as described with respect to FIGS.", "11C-11D.", "This way, a user can review the credentials to make sure that they are correct and/or correspond to the particular credentials that the user wished to use.", "In some implementations, the additional finger input is accomplished by the user lifting their finger off fingerprint sensor 169 to end the initial fingerprint 1110, and putting their finger back down on fingerprint sensor 169.Upon authentication of the second fingerprint, e.g., as matching an enrolled fingerprint of a user who is authorized to reveal the one or more credentials, the one or more credentials of the user previously displayed in redacted form are displayed in non-redacted form.", "Finger input 1112 shown in FIG.", "11C is an example of the aforementioned second fingerprint.", "As shown in FIG.", "11C, device 100 detects a finger input 1112 on fingerprint sensor 169 while displaying form 1101 with redacted credentials displayed in credential fields 1102.In response to finger input 1112, and in accordance with a determination that the fingerprint corresponding to finger input 1112 is associated with a user who is authorized to reveal the one or more credentials, non-redacted versions of the one or more credentials are displayed in the fields 1102 of form 1101, as shown in FIG.", "11D.", "For example, FIG.", "11D illustrates all of the credentials in form 1101 in plaintext.", "In the process shown and described with respect to FIGS.", "11A-11D, a first finger input (e.g., finger input 1110) causes a form to be filled in with redacted credentials, and a second finger input (e.g., finger input 1112) causes non-redacted versions of the credentials to be displayed in place of the redacted versions.", "In some embodiments, sequential finger inputs cause increasing amounts of one or more credentials to be displayed in non-redacted form.", "For example, after a first finger input is received (and after it is determined that the fingerprint of the input is associated with an authorized user), credential fields in a form are populated with redacted credentials.", "After a second finger input from an authorized user is received, a subset of the redacted credentials are replaced with non-redacted versions of the credentials, while others of the redacted credentials remain unchanged (e.g., remain in redacted form).", "Alternatively, after the second finger input, all or some of the redacted credentials are replaced with partially redacted versions of the credentials.", "Finally, after a third finger input, all of the credentials are displayed in non-redacted form.", "Accordingly, each sequential finger input of an authorized user causes redacted credentials to be replaced with less redacted (i.e., more readable) versions.", "This way, users can easily scale the degree to which their sensitive information is revealed in plaintext, while also allowing them to review the credentials that are automatically filled in to ensure that they are the correct and/or intended credentials.", "In some embodiments, the sequential inputs described above must be received and/or detected without intervening inputs (e.g., finger inputs, touch events, etc.).", "In some embodiments, the sequential inputs need not be received and/or detected without intervening inputs.", "In some embodiments, the order in which credentials are displayed in non-redacted form in response to a sequence of finger inputs depends on the relative security level of the credential.", "For example, in some embodiments, a non-redacted version of a shipping address is displayed in response to an earlier finger input in a sequence of finger inputs (e.g., because it is associated with a lower security and/or privacy level), and a non-redacted version of a credit card number is displayed in response to a later finger input in the sequence of finger inputs (e.g., because it is associated with a higher security and/or privacy level).", "FIGS.", "12A-12B are flow diagrams illustrating a method 1200 of populating credential fields with credentials, in accordance with some embodiments.", "The method 1200 is performed at an electronic device (e.g., device 300, FIG.", "3, or portable multifunction device 100, FIG.", "1A) with a display and a touch-sensitive surface.", "In some embodiments, the display is a touch screen display and the touch-sensitive surface is on the display.", "In some embodiments, the display is separate from the touch-sensitive surface.", "Some operations in method 1200 are, optionally, combined and/or the order of some operations is, optionally, changed.", "As described below, the method 1200 provides an intuitive way to enter credentials into credential fields that are displayed in a form, and display non-redacted versions of the credentials after redacted versions are initially displayed.", "The method reduces the cognitive burden on a user when presented with credential fields that need to be populated, thereby creating a more efficient human-machine interface.", "For battery-operated electronic devices, enabling a user to populate credential fields and enable display of non-redacted versions of credentials faster and more efficiently conserves power and increases the time between battery charges.", "The device stores a set of one or more credentials (1202).", "In some embodiments, credentials are secured credentials that are associated with a user of the device.", "In some embodiments, the set of one or more credentials is stored in memory of the device (e.g., memory 102, FIG.", "1A).", "In some embodiments, the credentials are stored in a secure area of memory 102, and/or are encrypted to prevent unauthorized access thereto.", "In some embodiments, the set of one or more credentials includes one or more of: a user ID, a password, a credit card number, a bank account number, an address, a telephone number, and/or a shopping credential (1204).", "In some implementations, the set of credentials includes a plurality of subsets of credentials, each subset corresponding to or associated with a distinct application, payment method, user, shipping address, online resource, set of online resources, or the like.", "In one example, the set of credentials include: for a first particular online resource (e.g., an email website), a user ID and a password; for a second particular online resource, a user ID, a password, a shipping address, a billing address, and a telephone number; and for shopping, a user ID, a credit card number, a shipping address, a billing address, and a telephone number.", "The device displays a form with fields corresponding to one or more credentials of the set of one or more credentials (1206).", "In some embodiments, the form is a webpage, such as a checkout page of an e-commerce website, a login page to a secure webpage (e.g., a social network, email provider, etc.", "), or the like.", "In some embodiments, the form is associated with a user interface of an application, such as a login screen of an application (or operating system).", "One exemplary form 1101, shown in FIGS.", "11A-11D, illustrates an example of a “checkout” page of an e-commerce website, and includes fields for credentials that are typical of a “checkout” or purchase authorization page (e.g., credit card information fields, billing address information fields, etc.).", "The device receives a request to automatically fill in the form with one or more credentials of the set of one or more credentials, wherein the request includes a finger input on the fingerprint sensor (1208).", "For example, when a form with credential fields is displayed, a user requests that the form be automatically filled with the appropriate credentials by placing a finger on the fingerprint sensor 169, as shown in FIG.", "11A.", "In some embodiments, the request to auto-fill the form corresponds to a request to populate all displayed fields of a form with credentials (or all fields for which credentials have been stored).", "In some embodiments, the request to auto-fill the form corresponds to a request to populate all fields of the form with credentials, regardless of whether they are displayed when the request is received (e.g., undisplayed fields of the form, such as those that are “off screen,” are also populated in response to the request).", "In some embodiments, when the device detects that a form having appropriate credential fields is displayed or to be displayed, the device prompts the user to provide an input in order to request automatic filling (“auto-fill”) of a form, such as by presenting the text “Scan your fingerprint to automatically fill in this form.” In response to receiving the request to automatically fill in the form: in accordance with a determination that the finger input includes a fingerprint that is associated with a user who is authorized to use the set of one or more credentials, the device fills in the form with the one or more credentials; and in accordance with a determination that the finger input includes a fingerprint that is not associated with a user who is authorized to use the set of one or more credentials, the device forgoes filling in the form with the one or more credentials (1210).", "In some embodiments, the determination that the fingerprint is associated with a user who is authorized to use the set of one or more credentials includes a determination that the fingerprint matches at least one of a set of one or more enrolled fingerprints (1212).", "For example, if the fingerprint corresponding to finger input 1110 (FIG.", "11A) matches an enrolled fingerprint, the device fills in the form (i.e., the fields of the form) with the stored credentials, as shown in FIG.", "11B.", "If, on the other hand, the fingerprint corresponding to finger input 1110 does not match an enrolled fingerprint, the device will not fill in the form.", "In some embodiments, the device will provide an indication that the fingerprint did not match an enrolled fingerprint, such as an audible or visible alert.", "For example, the device will display a prompt with the text “Auto-fill authorization denied—please try again.” In some implementations, one or more enrolled fingerprints are associated with a user who is authorized to use the set of one or more credentials, while one or more other enrolled fingerprints are not associated with a user who is authorized to use the set of one or more credentials.", "In such implementations, the determination that the fingerprint is associated with a user who is authorized to use the set of one or more credentials includes a determination that the fingerprint matches at least one enrolled fingerprint that is associated with a user who is authorized to use the set of one or more credentials.", "In some implementations, different enrolled fingerprints are associated with different sets of credentials or different subsets of the set of credentials stored in the device.", "In one example, one or more enrolled fingerprints are associated with a user who is authorized to use all of the credentials, or a first subset of the credentials that is less than all the credentials, in the set of one or more credentials, while one or more other enrolled fingerprints are associated with another user who is authorized to use only a second subset of the credentials that is less than all the credentials and that is different from the first subset of the credentials.", "Other examples of associating different enrolled fingerprints with different sets or subsets of credentials are possible.", "In some such implementations, the determination that a fingerprint in a finger input is associated with a user who is authorized to use the set of one or more credentials includes both a determination that the fingerprint matches at least one of a set of one or more enrolled fingerprints, and if so, a determination of whether the use one or more respective credentials in the set of one or more credentials is authorized by the fingerprint.", "In some embodiments, the determination that the fingerprint is associated with a user who is authorized to use the set of one or more credentials and/or the determination that the fingerprint matches at least one of a set of one or more enrolled fingerprints is performed by the device (e.g., with fingerprint analysis module 131 of device 100).", "In some embodiments, the determinations are performed by one or more additional devices instead of or in addition to the device.", "In some embodiments, if a predetermined number of consecutive requests to auto-fill a form are denied (e.g., 2, 3, 4, 5, or more denials), the device performs one or more actions.", "For example, in order to protect sensitive information from unauthorized access and/or use, the device disables an auto-fill functionality (e.g., for a predetermined time, or until a valid override password is input by a user), or deletes stored credentials from memory.", "With reference to FIG.", "12B, in some embodiments, filling in the form with the one or more credentials includes displaying redacted versions of the one or more credentials in one or more fields of the form (1214).", "In some embodiments, a respective credential is redacted when at least a portion of the respective credential is rendered unreadable to a user of the device (e.g., by removing, replacing or obscuring characters, or by blocking out all or a portion of the characters in the respective credential).", "For example, the credentials in FIG.", "11B (e.g., credit card credential 1104) are illustrated as a series of dots.", "In some embodiments, while displaying the redacted versions of the one or more credentials in one or more fields of the form, the device detects a respective fingerprint on the fingerprint sensor; and in response to detecting the respective fingerprint and in accordance with a determination that the respective fingerprint is associated with a user who is authorized to reveal the one or more credentials, displays a non-redacted version of the one or more credentials in the fields of the form (1216).", "For example, FIG.", "11D illustrates the device displaying non-redacted versions of credentials in response to a finger input 1112 (shown in FIG.", "11C) corresponding to a fingerprint of an authorized user.", "In some embodiments, the same fingerprints that are authorized to use the set of credentials are also authorized to reveal the set of one or more credentials.", "In some embodiments, one or more fingerprints that are authorized to use the credentials are not authorized to reveal the credentials.", "As shown in FIGS.", "11A-11D, the device initially displays credentials in redacted form, and, if certain conditions are met, subsequently displays non-redacted versions of the credentials.", "In some embodiments, the redacted version of a respective credential includes an indication of a length of the respective credential; and the non-redacted version of the respective credential includes a human readable version of the respective credential (1218).", "A redacted credential can indicate the length of the underlying credential in several ways.", "For example, in some embodiments, the redacted version of a respective credential includes a symbol (e.g., a dot, asterisk, letter, etc.)", "for each character in the respective credential.", "Credential 1104 in FIGS.", "11B-11D illustrates an example of this, where one dot is displayed for each number in the credit card number.", "In some embodiments, the redacted version of a respective credential includes a symbol or graphic whose length is proportional to the length of the respective credential (e.g., a black bar, a horizontal line, etc.).", "In some embodiments, a human readable version of the respective credential is a plaintext version of the credential (i.e., the actual text, symbols, numbers, characters, etc., of the credential).", "In some embodiments, or in some circumstances, the redacted version of a respective credential includes a non-redacted portion of the respective credential; and the non-redacted version of the respective credential includes a human readable version of the entire respective credential (1220).", "In some embodiments, the particular portion of the redacted credential that is non-redacted depends on the credential.", "For example, in the case of a credit card number, the last four digits are displayed in plaintext in the redacted version.", "In the case of an address credential, the house number (and/or the city or state) is displayed in plaintext in the redacted version, and the rest of the address (e.g., the street name and zip code) is redacted.", "Other portions of these credentials are displayed in non-redacted form in various embodiments.", "Devices are sometimes used by multiple, different users, each having a different set of credentials that they are likely to use.", "For example, each user may have a unique username and password for an email account, a unique credit card number.", "unique login credentials for social networking services, and the like.", "Moreover, in some embodiments, a device can register fingerprints for multiple users, such that the device can identify a user making a request by comparing a received fingerprint to the registered fingerprints of the multiple users.", "Accordingly, in some embodiments, in response to receiving the request to automatically fill in the form, the device identifies which user has issued the request (e.g., by comparing the fingerprint of the finger input 1110 to the registered fingerprints), and automatically fills in the form with credentials corresponding to the identified user.", "Thus, personalized auto-fill based on fingerprint recognition is provided for multiple different users of a single device.", "Similarly, a user of a device may have multiple different instances of a particular type of credential.", "For example, a user may have multiple email accounts, each with its own unique email address and password.", "A user may also have multiple credit cards, each associated with unique credit card information.", "Further, a user may have multiple different mailing addresses (e.g., a home address and a business address).", "In some embodiments, respective sets of one or more credentials of a user are associated with different respective fingerprints of the user.", "For example, credentials of a first credit card and billing address are associated with a fingerprint of a right thumb (RT) of the user, and a second credit card and billing address are associated with a fingerprint of a right index (RI) finger.", "As another example, credentials for a credit card are associated with a fingerprint of a right thumb (RT) of the user, and login credentials for a social networking service are associated with a fingerprint of a right index (RI) finger.", "Accordingly, in some embodiments, the device selects a set of one or more credentials (from among multiple sets) that correspond to the particular fingerprint detected by the fingerprint sensor, and auto-fills the form with the selected set of one or more credentials.", "Other associations between fingers and sets of credentials than those described above are also possible.", "For example, any credential or set of credentials described herein can be associated with any unique fingerprint, whether it is a different finger of the same user, or a finger of a different user.", "It should be understood that the particular order in which the operations in FIGS.", "12A-12B have been described is merely exemplary and is not intended to indicate that the described order is the only order in which the operations could be performed.", "One of ordinary skill in the art would recognize various ways to reorder the operations described herein.", "Additionally, it should be noted that details of other processes described herein with respect to other methods described herein (e.g., those listed in the “Description of Embodiments” section above) are also applicable in an analogous manner to method 1200 described above with respect to FIGS.", "12A-12B.", "For example, the fingerprints, contacts, and user interface objects described above with reference to method 1200 optionally have one or more of the characteristics of the fingerprints, contacts, and user interface objects described herein with reference to other methods described herein (e.g., those listed in the “Description of Embodiments” section above).", "For brevity, these details are not repeated here.", "In accordance with some embodiments, FIG.", "13 shows a functional block diagram of an electronic device 1300 configured in accordance with the principles of the various described embodiments.", "The functional blocks of the device are, optionally, implemented by hardware, software, or a combination of hardware and software to carry out the principles of the various described embodiments.", "It is understood by persons of skill in the art that the functional blocks described in FIG.", "13 are, optionally, combined or separated into sub-blocks to implement the principles of the various described embodiments.", "Therefore, the description herein optionally supports any possible combination or separation or further definition of the functional blocks described herein.", "As shown in FIG.", "13, an electronic device 1300 includes a display unit 1302 configured to display a form with fields corresponding to one or more credentials of the set of one or more credentials, an optional touch-sensitive surface unit 1304 configured to receive contacts, a fingerprint sensor unit 1306; a credential storage unit 1307 configured to store a set of one or more credentials, and a processing unit 1308 coupled to the display unit 1302, the optional touch-sensitive surface unit 1304, the credential storage unit 1307, and the fingerprint sensor unit 1306.In some embodiments, the processing unit 1308 includes a request receiving unit 1310, a form filling unit 1312, a display enabling unit 1314, and a fingerprint matching unit 1316.Processing unit 1308 is configured to: receive a request to automatically fill in the form with one or more credentials of the set of one or more credentials (e.g., with request receiving unit 1310), wherein the request includes a finger input on the fingerprint sensor (e.g., fingerprint sensor unit 1306); and in response to receiving the request to automatically fill in the form: in accordance with a determination that the finger input includes a fingerprint that is associated with a user who is authorized to use the set of one or more credentials, fill in the form with the one or more credentials (e.g., with form filling unit 1312); and in accordance with a determination that the finger input includes a fingerprint that is not associated with a user who is authorized to use the set of one or more credentials, forgo filling in the form with the one or more credentials (e.g., with form filling unit 1312).", "In some embodiments, the set of one or more credentials includes one or more of: a user ID, a password, a credit card number, a bank account number, an address, a telephone number, and a shopping credential.", "In some embodiments, filling in the form with the one or more credentials includes enabling display of redacted versions of the one or more credentials in one or more fields of the form (e.g., with display enabling unit 1314).", "In some embodiments, the fingerprint sensor unit 1306 is configured to, while the redacted versions of the one or more credentials are displayed in one or more fields of the form, detect a respective fingerprint on the fingerprint sensor; and the processing unit 1308 is further configured to, in response to detection of the respective fingerprint and in accordance with a determination that the respective fingerprint is associated with a user who is authorized to reveal the one or more credentials (e.g., with fingerprint matching unit 1316), enable display of a non-redacted version of the one or more credentials in the fields of the form (e.g., with display enabling unit 1314).", "In some embodiments, the redacted version of a respective credential includes an indication of a length of the respective credential; and the non-redacted version of the respective credential includes a human readable version of the respective credential.", "In some embodiments, the redacted version of a respective credential includes a non-redacted portion of the respective credential; and the non-redacted version of the respective credential includes a human readable version of the entire respective credential.", "In some embodiments, the determination that the fingerprint is associated with a user who is authorized to use the set of one or more credentials includes a determination that the fingerprint matches at least one of a set of one or more enrolled fingerprints.", "In some embodiments, the device 1300 determines that the fingerprint matches at least one of a set of one or more enrolled fingerprints (e.g., with fingerprint matching unit 1316).", "FIG.", "14A illustrates an exemplary user interface that is displayed on a display of a portable multi-function device 100.The user interface displays a selection page 1402 that includes one or more selectable user interface objects, including a credential manager icon 1404.The page selection 1402 illustrates one possible example of an interface in which a user can request the display of stored credentials (e.g., by requesting activation and/or display of a credential manager interface).", "As shown in FIG.", "14A, device 100 receives a request to display the set of one or more credentials (e.g., contact 1406, indicating a user selection of credential manager icon 1404).", "FIG.", "14B illustrates an exemplary settings manager interface 1403 that is displayed in response to the contact 1406.The settings manager interface 1403 includes fields 1408 (1408-1, .", ".", ".", ", 1408-6) corresponding to one or more credentials.", "Fields 1408 correspond to examples of credentials that are stored by the device 100, according to some embodiments.", "For example, fields 1408 include a username field 1408-1 and a password field 1408-2 associated with an email account, a user ID field 1408-3 and a password field 1408-4 associated with an account for a shopping website/application, and a user ID field 1408-5 and a password field 1408-6 associated with a social network account.", "Other credential fields are possible, including credit card information fields, and the like.", "The device 100 displays redacted versions of the credentials in each of the fields 1408.In this example, the redacted credentials are represented as sequences of dots.", "However, other redaction techniques are also contemplated (e.g., any removal, replacement or obscuration of the characters such that the credentials are unreadable by a user of the device).", "As shown in FIG.", "14B, device 100 detects a finger input 1406 on fingerprint sensor 169 while displaying redacted credentials in credential fields 1408 of settings manager interface 1403.Device 100 detects a fingerprint included with finger input 1406, and, in response to detecting the fingerprint and if the fingerprint is associated with an authorized user, device 100 displays the credentials in fields 1406 in non-redacted form, as shown in FIG.", "14C.", "Specifically, FIG.", "14C illustrates the settings manager interface 1403 with the credentials displayed in plaintext so that they are readable (and/or editable) by a user of the device.", "FIGS.", "15A-15B are flow diagrams illustrating a method 1500 of revealing redacted credentials, in accordance with some embodiments.", "The method 1500 is performed at an electronic device (e.g., device 300, FIG.", "3, or portable multifunction device 100, FIG.", "1A) with a display and a touch-sensitive surface.", "In some embodiments, the display is a touch screen display and the touch-sensitive surface is on the display.", "In some embodiments, the display is separate from the touch-sensitive surface.", "Some operations in method 1500 are, optionally, combined and/or the order of some operations is, optionally, changed.", "As described below, the method 1500 provides an intuitive way to reveal redacted credentials.", "The method reduces the cognitive burden on a user when attempting to review or edit credentials that are displayed in redacted form, thereby creating a more efficient human-machine interface.", "For battery-operated electronic devices, enabling a user to reveal redacted credentials faster and more efficiently conserves power and increases the time between battery charges.", "The device stores a set of one or more credentials (1502).", "As described above, in some embodiments, credentials are secured credentials that are associated with a user of the device, and are stored in memory of the device (e.g., memory 102, FIG.", "1A).", "In some embodiments, the credentials are stored in a secure area of memory, and/or are encrypted to prevent unauthorized access to the credentials.", "In some embodiments, the set of one or more credentials includes credentials that correspond to a plurality of different accounts of a user of the device (1504).", "For example, a user may store on the device credentials for multiple different accounts, such as one or more email accounts, one or more payment accounts (e.g., credit cards, bank accounts, online payment accounts, and the like), shopping credentials (e.g., usernames and passwords for e-commerce websites and/or applications), credentials for social network accounts, and the like.", "FIG.", "14B illustrates examples of credentials corresponding to a plurality of different accounts of a user of a device.", "In some embodiments, the set of one or more credentials includes passwords for a plurality of different accounts of a user of the device (1506).", "For example, as shown in FIG.", "14B, the set of one or more credentials includes a password for a webmail account (e.g., credential field 1408-2), a password for a shopping site (e.g., credential field 1408-4), and a password for a social network account (e.g., credential field 1408-6).", "In some embodiments, the set of one or more credentials includes payment authorization information for a plurality of different payment accounts of a user of the device (1508).", "Payment authorization information includes, for example, credit card information (e.g., credit card numbers, expiration dates, security codes, billing addresses, etc.", "), online payment account information (e.g., account numbers, user identifiers, passwords, etc.", "), bank account information (e.g., bank account numbers, routing numbers, user identifiers, passwords, etc.", "), and the like.", "In some embodiments, the set of one or more credentials includes one or more of: a user ID, a password, a credit card number, a bank account number, an address, a telephone number, and/or a shopping credential (1510).", "Examples of these credentials are described above, and are illustrated in FIGS.", "11A-11D and 14B-14C.", "The device receives a request to display the set of one or more credentials (1512).", "In some embodiments, the request includes a user selection of a selectable user interface object (e.g., an icon).", "For example, FIG.", "14A illustrates contact 1406 indicating a user selection of credential manager icon 1404.In response to receiving the request to display the set of one or more credentials (e.g., contact 1406), the device displays redacted versions of the set of one or more credentials (1514).", "In some embodiments, the redacted versions of the set of one or more credentials are displayed in a “credential manager” interface, as illustrated in FIG.", "14B.", "In some embodiments, the redacted versions of the credentials are identified with (e.g., displayed near or otherwise in association with) non-redacted human readable text (i.e., a label) that indicates the type of credential.", "Non-limiting examples of credential labels include username; user identifier; email address; password; credit card number; expiration date; etc.", "In some embodiments, the redacted versions of the credentials are identified with non-redacted human readable text (i.e., a label) that indicates which account a particular redacted credential is associated with.", "For example, FIG.", "14B illustrates webmail credentials displayed in association with text indicating the account (“Webmail Account”), as well as text indicating the type of each credential (“Username” and “Password”).", "While displaying the redacted versions of the set of one or more credentials, the device detects a fingerprint on the fingerprint sensor (1516).", "For example, FIG.", "14B illustrates finger input 1406 (including a fingerprint) on fingerprint sensor 169 while the redacted versions of the credentials are displayed in the credential manager 1403.In response to detecting the fingerprint and in accordance with a determination that the fingerprint is associated with a user who is authorized to reveal the set of one or more credentials, the device displays a non-redacted version of the set of one or more credentials (1518).", "FIG.", "14C illustrates the device 100 displaying plaintext versions of the credentials that were redacted in FIG.", "14B, in response to detection of a fingerprint (e.g., finger input 1406) and a determination that the fingerprint is associated with an authorized user.", "In some embodiments, the determination that the fingerprint is associated with a user who is authorized to reveal the set of one or more credentials includes a determination that the fingerprint matches at least one of a set of one or more enrolled fingerprints (1520).", "In some embodiments, the determination that the fingerprint is associated with a user who is authorized to reveal the set of one or more credentials and/or the determination that the fingerprint matches at least one of a set of one or more enrolled fingerprints is performed by the device (e.g., with fingerprint analysis module 131 of device 100).", "In some embodiments, the determinations are performed by one or more additional devices instead of or in addition to the device.", "With reference to FIG.", "15B, in some embodiments, the redacted version of a respective credential includes an indication of a length of the respective credential; and the non-redacted version of the respective credential includes a human readable version of the respective credential (1522).", "For example, in some implementations, the redacted version of a respective credential includes a symbol (e.g., a dot, asterisk, letter, etc.)", "for each character in the respective credential.", "Credential 1104 in FIGS.", "11B-11D illustrates an example of this, where one dot is displayed for each number in the credit card number.", "In some embodiments, the redacted version of a respective credential includes a symbol or graphic whose length is proportional to the length of the respective credential (e.g., a black bar, a horizontal line, etc.).", "In some embodiments, a human readable version of the respective credential is a plaintext version of the credential (i.e., the actual text, symbols, numbers, characters, etc., of the credential).", "In some embodiments, the redacted version of a respective credential includes a non-redacted portion of the respective credential; and the non-redacted version of the respective credential includes a human readable version of the entire respective credential (1524).", "In some embodiments, the particular portion of the redacted credential that is non-redacted depends on the credential.", "For example, in the case of a credit card number, the last four digits are displayed in plaintext in the redacted version.", "In the case of an address credential, the house number (and/or the city or state) is displayed in plaintext in the redacted version, and the rest of the address (e.g., the street name and zip code) is redacted.", "Other portions of these credentials are displayed in non-redacted form in various embodiments.", "It should be understood that the particular order in which the operations in FIGS.", "15A-15B have been described is merely exemplary and is not intended to indicate that the described order is the only order in which the operations could be performed.", "One of ordinary skill in the art would recognize various ways to reorder the operations described herein.", "Additionally, it should be noted that details of other processes described herein with respect to other methods described herein (e.g., those listed in the “Description of Embodiments” section above) are also applicable in an analogous manner to method 1500 described above with respect to FIGS.", "15A-15B.", "For example, the fingerprints, contacts, and user interface objects described above with reference to method 1500 optionally have one or more of the characteristics of the fingerprints, contacts, and user interface objects described herein with reference to other methods described herein (e.g., those listed in the “Description of Embodiments” section above).", "For brevity, these details are not repeated here.", "In accordance with some embodiments, FIG.", "16 shows a functional block diagram of an electronic device 1600 configured in accordance with the principles of the various described embodiments.", "The functional blocks of the device are, optionally, implemented by hardware, software, or a combination of hardware and software to carry out the principles of the various described embodiments.", "It is understood by persons of skill in the art that the functional blocks described in FIG.", "16 are, optionally, combined or separated into sub-blocks to implement the principles of the various described embodiments.", "Therefore, the description herein optionally supports any possible combination or separation or further definition of the functional blocks described herein.", "As shown in FIG.", "16, an electronic device 1600 includes a display unit 1602, an optional touch-sensitive surface unit 1604 configured to receive contacts, a fingerprint sensor unit 1606; a credential storage unit 1607 configured to store a set of one or more credentials, and a processing unit 1608 coupled to the display unit 1602, the optional touch-sensitive surface unit 1604, the credential storage unit 1607, and the fingerprint sensor unit 1606.In some embodiments, the processing unit 1608 includes a request receiving unit 1610, a display enabling unit 1612, and a fingerprint matching unit 1614.Processing unit 1608 is configured to: receive a request to display the set of one or more credentials (e.g., with request receiving unit 1610); in response to receiving the request to display the set of one or more credentials, enable display of redacted versions of the set of one or more credentials (e.g., with display enabling unit 1612); and in response to detection of a fingerprint on the fingerprint sensor while the redacted versions of the set of one or more credentials are displayed, and in accordance with a determination that the fingerprint is associated with a user who is authorized to reveal the set of one or more credentials (e.g., with fingerprint matching unit 1614), enable display of a non-redacted version of the set of one or more credentials (e.g., with display enabling unit 1612).", "In some embodiments, the set of one or more credentials includes credentials that correspond to a plurality of different accounts of a user of the device.", "In some embodiments, the set of one or more credentials includes passwords for a plurality of different accounts of a user of the device.", "In some embodiments, the set of one or more credentials includes payment authorization information for a plurality of different payment accounts of a user of the device.", "In some embodiments, the set of one or more credentials includes one or more of: a user ID, a password, a credit card number, a bank account number, an address, a telephone number, and a shopping credential.", "In some embodiments, the redacted version of a respective credential includes an indication of a length of the respective credential; and the non-redacted version of the respective credential includes a human readable version of the respective credential.", "In some embodiments, the redacted version of a respective credential includes a non-redacted portion of the respective credential; and the non-redacted version of the respective credential includes a human readable version of the entire respective credential.", "In some embodiments, the determination that the fingerprint is associated with a user who is authorized to reveal the set of one or more credentials includes a determination that the fingerprint matches at least one of a set of one or more enrolled fingerprints.", "In some embodiments, the device 1600 determines that the fingerprint matches at least one of a set of one or more enrolled fingerprints (e.g., with fingerprint matching unit 1614).", "The operations in the information processing methods described above are, optionally implemented by running one or more functional modules in information processing apparatus such as general purpose processors (e.g., as described above with respect to FIGS.", "1A and 3) or application specific chips.", "The operations described above with reference to FIGS.", "12A-12B and 15A-15B are, optionally, implemented by components depicted in FIGS.", "1A-1B or FIG.", "13 or 16.For example, display operation 1206, request receiving operation 1208, and form filling operation 1210 (FIG.", "12A) and request receiving operation 1512, credential display operation 1514, fingerprint detection operation 1516, and credential revealing operation 1518 (FIG.", "15A) are, optionally, implemented by event sorter 170, event recognizer 180, and event handler 190.Event monitor 171 in event sorter 170 detects a contact on touch-sensitive display 112, and event dispatcher module 174 delivers the event information to application 136-1.A respective event recognizer 180 of application 136-1 compares the event information to respective event definitions 186, and determines whether a first contact at a first location on the touch-sensitive surface corresponds to a predefined event or sub-event, such as selection of an object on a user interface.", "When a respective predefined event or sub-event is detected, event recognizer 180 activates an event handler 190 associated with the detection of the event or sub-event.", "Event handler 190 optionally utilizes or calls data updater 176 or object updater 177 to update the application internal state 192.In some embodiments, event handler 190 accesses a respective GUI updater 178 to update what is displayed by the application.", "Similarly, it would be clear to a person having ordinary skill in the art how other processes can be implemented based on the components depicted in FIGS.", "1A-1B.", "Managing Usage of Saved Credentials Many electronic devices provide services that require particular credentials that are used by the devices or service providers to determine a user's eligibility for receiving the services.", "Such credentials frequently comprise information that is not easily accessible to people other than the particular user(s) associated with the credentials.", "Examples of a credential include a passcode, a registered username-password combination, a stored answer to a security question, credit card information, a social security number, and so on.", "Although requiring the user to input the correct credential each time the user wishes to access a particular service may promote security, such requirement is also cumbersome and time consuming.", "As described herein, automatically saving a credential that was previously provided on the device for accessing a function or service and subsequently allowing the user to access the function or service again through an enrolled fingerprint help to streamline the user's access to the function or service without significantly compromising the required level of access security.", "In addition, as described herein, in some embodiments, it is possible for a device to have multiple enrolled fingerprints at any given time, and a user may enroll one or more additional fingerprints while the device is in an unlocked state.", "It is therefore important to have a method to securely manage the automatic usage of saved credentials when one or more additional fingerprints are enrolled since the credential was last used.", "As described herein, in some embodiments, after a fingerprint enrollment process is successfully completed and one or more fingerprints are enrolled, the device automatically saves each credential manually entered by the user.", "When any of the saved credentials is subsequently required on the device (e.g., by a software application or online service provider), the device automatically prompts the user to provide an enrolled fingerprint in lieu of requesting the user to manually input the required credential.", "When the user provides a valid fingerprint, the device automatically retrieves and uses an appropriate saved credential on behalf of the user.", "In the event that one or more additional fingerprints have been enrolled subsequently (or, in some embodiments, in the event that an attempt has been made to add an additional fingerprint), automatic usage of the previously saved credentials is automatically disabled (e.g., by discarding the previously saved credentials, or changing a predefined usage setting).", "As such, when a credential is subsequently required on the device, the device prompts the user to manually enter the credential rather than accepting any fingerprint input.", "After the user provides the correct credential, the device saves the credential and re-enables automatic usage of the saved credential through enrolled fingerprints.", "Such automatic management of saved credentials improves access security on the device.", "For example, if a second user adds (or, in some embodiments, attempts to add) his or her fingerprint to the set of enrolled fingerprints, the enrolled fingerprints cannot be used authorize usage of the previously saved credential until after the credential has been re-entered.", "In some embodiments, the device is an electronic device with a separate display (e.g., display 450) and a separate touch-sensitive surface (e.g., touch-sensitive surface 451).", "In some embodiments, the device is portable multifunction device 100, the display is touch screen 112, and the touch-sensitive surface includes tactile output generators 167 on the display (FIG.", "1A).", "The device described below with reference to 17A-17J and 18A-18C includes one or more fingerprint sensors 169.In some embodiments, the one or more fingerprint sensors include one or more integrated fingerprint sensors 359-1 (FIG.", "4B) that are integrated in to the touch-sensitive surface (e.g., separate touch-sensitive surface 451 or touch sensitive display system 112).", "In some embodiments, the one or more fingerprint sensors include separate fingerprint sensors 359-2 (FIG.", "4B) that are separate from the touch-sensitive surface (e.g., separate touch-sensitive surface 451 or touch sensitive display system 112).", "Unless specified otherwise, a fingerprint sensor 169 described below is, optionally, either an integrated fingerprint sensor 359-1 or a separate fingerprint sensor 359-2, depending on the configuration of the hardware and software of the device that includes the fingerprint sensor 169.For convenience of explanation, the embodiments described with reference to FIGS.", "17A-17J and 18A-18C will be discussed with reference to a device with a touch screen 112 and a separate fingerprint sensor 359-2, however analogous operations are, optionally, performed on a device with an integrated fingerprint sensor 359-1 in response to detecting the inputs described in FIGS.", "17A-17J on the integrated fingerprint sensor 359-1 while displaying the user interfaces shown in FIGS.", "17A-17J on the display 450.Additionally, analogous operations are, optionally, performed on a device with a display 450 and a separate touch-sensitive surface 451 instead of a touch screen 112 in response to detecting the contacts described in FIGS.", "17A-17J on a fingerprint sensor 169 (e.g., an integrated fingerprint sensor 359-1 or a separate fingerprint sensor 359-2) and/or the separate touch-sensitive surface 451 while displaying the user interfaces shown in FIGS.", "17A-17J on the display 450; in such embodiments, the contacts shown in FIGS.", "17A-17J optionally represent both a focus selector that corresponds to a location on the display 450, and a contact that corresponds to a location of a contact or gesture performed on the separate touch-sensitive surface (e.g., touch-sensitive surface 451), where the focus selector is, optionally: a respective contact, a representative point corresponding to a contact (e.g., a centroid of a respective contact or a point associated with a respective contact), or a centroid of two or more contacts detected on the touch screen 112 and is, optionally, replaced with a displayed cursor.", "FIGS.", "17A-17J illustrate an exemplary process that occurs on an electronic device (e.g., device 100) and demonstrate how the automatic usage of saved credentials through enrolled fingerprints are managed (e.g., allowed and prevented) in accordance with some embodiments.", "FIGS.", "17A-17D illustrate the automatic retrieval and usage of a saved credential through a previously enrolled fingerprint.", "FIGS.", "5E-5H illustrate subsequent enrollment of an additional fingerprint and the resulting disablement of the saved credential.", "FIGS.", "5H-5J illustrates manual entry of the credential by the user, and the automatic saving and re-enablement of the credential, where the re-enabled credential is made available for subsequent retrieval and use through enrolled fingerprints.", "The exemplary scenario shown in FIGS.", "17A-17D occurs after a user of the electronic device (e.g., device 100) has already registered a set of one or more fingerprints (e.g., through the processes described in method 600), and enabled automatic usage of saved credentials through enrolled fingerprints (e.g., through a fingerprint usage setting described in method 600).", "In addition, during the first occasion after the enrollment of the set of fingerprints that a particular credential (e.g., a passcode of a registered online shopping account) is required on the device, the user is prompted to manually enter the credential.", "In response to receiving the manual entry of the credential, the device uses the credential to provide access to the function or service (e.g., making a purchase at an online store), and automatically saves a copy of the credential for future use through the set of enrolled fingerprints.", "Before the start of the exemplary scenario shown in FIG.", "17A, a copy of the credential (e.g., the passcode of the online shopping account) has been saved on the device 100, and the user has returned again to the same online store after the previous shopping session had been terminated (e.g., through timeout or formal exit).", "As shown in FIG.", "17A, the user has identified an item (e.g., a software application 1702) for purchase in the online store (e.g., an app store), and is presented with a user interface 1704 showing the detailed description of the item.", "The user interface 1704 includes a user interface element 1706 for purchasing the item using a registered online shopping account.", "In some embodiments, the online store has stored the necessary payment information (e.g., shipping address, billing address, credit card information, store credit, etc.)", "in association with the registered shopping account, and will apply the stored payment information when the passcode associated with the registered shopping account is received from the user at the time of the purchase.", "As shown in FIGS.", "17A-17B, when the user selects (e.g., using a touch input 1708) the user interface element 1706 to proceed with the purchase of the software application 1702, the device 100 determines (e.g., through a notification received from the online store) that a particular registered account passcode is required by the online store for completing the purchase.", "The device 100 further determines that the registered account passcode has been previously entered and saved on the device.", "In accordance with such determinations, the device 100 presents a prompt (e.g., a pop-up window 1710) instructing the user to provide an enrolled fingerprint to use the saved passcode to proceed with the purchase.", "In some embodiments, the device 100 activates the fingerprint sensor 169 separate from the touch screen 112 to detect and capture any fingerprint input provided on the home button 204.In some embodiments, the device selectively activates a high-resolution region 1712 on the touch-screen 112 within the pop-up window 1710 to serve as a fingerprint sensor.", "In some embodiments, the device displays an animation (e.g., a glowing fingerprint graphic) to visually indicate the activated high-resolution region 1712 to the user.", "In some embodiments, as shown in FIG.", "17B, the pop-up window 1710 further displays a user interface element 1714 for canceling the current operation and returning to the user interface 1704 shown in FIG.", "17A.", "In some embodiments, as shown in FIG.", "17B, the pop-up window 1710 also displays a user interface element 1716 for manually entering the required account passcode using a keypad.", "Although not shown in this exemplary interaction scenario, a person of ordinary skill in the art would understand that, if the user selects the user interface element 1716, instead of providing an enrolled fingerprint, the device will present an alternate user interface that allows the user to type in the required passcode or to switch to a different online shopping account.", "As shown in FIG.", "17C, the user has provided a fingerprint input 1718 through the fingerprint sensor 169 on the home button 204.The device 100 captures the fingerprint input 1718 and determines that the received fingerprint matches one of the set of fingerprints currently enrolled on the device 100.The device 100 further determines that the required account passcode is currently stored on the device 100 and is not currently disabled (e.g., an exemplary scenario illustrating disablement of a saved passcode is shown later in FIGS.", "17E-17H).", "In accordance with such determinations, the device retrieves the saved account passcode, and provides the saved account passcode to the online store on behalf of the user.", "In some embodiments, automatic population of the saved account passcode into the online store's passcode interface is presented to the user through an animation.", "In some embodiments, as shown in FIG.", "17D, the saved passcode is provided to the online store in the background, and the user is presented with a user interface 1720 indicating transaction success after the saved passcode has been accepted by the online store.", "In this example, the purchase of the selected item has been confirmed, and download of the purchased application has been started.", "FIGS.", "17A-17D illustrate how a saved credential (e.g., an account passcode) can be used on behalf of the user through an enrolled fingerprint provided by the user.", "FIGS.", "17E-17H illustrate how use of a saved credential can be disabled after an additional fingerprint has been enrolled after the credential is saved.", "Disabling automatic usage of a saved credential after enrollment of one or more additional fingerprints provides an alert to the user (either implicitly or explicitly) that additional fingerprints have been enrolled.", "If the enrollment of the additional fingerprints is not objectionable to the user, the user can manually provide the required credential to re-enable the automatic usage of the credential through any of the set of fingerprints currently enrolled on the device 100.As shown in FIGS.", "17E-17F, after the user has exited the shopping interface of the online store, and while the account passcode for the online store remains a saved credential on the device 100, a new fingerprint has been successfully registered on the device 100.A detailed description of an exemplary process for enrolling an additional fingerprint is described with reference to method 600.As a result of the enrollment of the new fingerprint, the device 100 determines that, at least one fingerprint (e.g., the new fingerprint) in the set of currently enrolled fingerprints on device 100 is registered after the saved account passcode was last used.", "According to this determination, the device 100 disables the automatic usage of the saved account passcode.", "In other words, in some embodiments, even if a user were to provide the same fingerprint that he or she had previously used to apply the saved account passcode to the online store, this fingerprint will no longer achieve the same result because the automatic usage of the saved account passcode has been disabled.", "In some embodiments, the automatic usage of the saved account passcode (or other credential) is not disabled for the previously enrolled fingerprints, but is disabled for the newly enrolled fingerprint until the user has manually entered the account passcode to associate/connect the account passcode with the newly enrolled fingerprint.", "As shown in FIGS.", "17G-17H, when the user returns to the same online store at a later time and wishes to make another purchase using the same online shopping account, instead of prompting the user to provide an enrolled fingerprint, the device 100 provides a prompt for the user to manually enter the required passcode.", "As shown in FIG.", "17G, the user has identified an item (e.g., an interactive book 1724) for purchase in the same online store, and is presented with a user interface 1726 showing the detailed descriptions of the item.", "The user interface 1726 includes a user interface element 1728 for purchasing the item using a registered online shopping account.", "When the user selects (e.g., using a touch input 1730) the user interface element 1728 to proceed with the purchase of the interactive book 1724, the device 100 determines again (e.g., through a notification received from the online store) that a particular registered account passcode is required by the online store for completing the purchase.", "The device 100 further determines that automatic usage of the previously saved account passcode has been disabled on the device (e.g., due to the enrollment of the additional fingerprint as shown in FIGS.", "17E-17F).", "In some embodiments, the previously saved account passcode has been deleted from the device 100 through disablement, and the device 100 simply determines that no saved account passcode is available at this time.", "In accordance with either of these determinations, as shown in FIG.", "17H, the device 100 presents a prompt (e.g., a pop-up window 1730) for the user to manually enter the required account passcode to proceed with the purchase.", "FIG.", "17I illustrates that the user has provided the required passcode in the pop-up window 1730 (e.g., using the soft keypad 1732 provided along with the pop-up window 1730).", "The device 100 transmits the received passcode to the online store in the usual manner (e.g., in an encrypted form).", "When the online store verifies and accepts the user-entered passcode, the device 100 presents a user interface 1738 indicating that the purchase has been confirmed and download of the purchased interactive book has been started, as shown in FIG.", "17J.", "At this point, once the manually entered passcode has been accepted by the online store, the device 100 automatically saves the account passcode, and once again enables automatic retrieval and usage of the saved account passcode through enrolled fingerprints (e.g., any of the set of currently enrolled fingerprints) in the next transaction in which the account passcode is required.", "For example, the next purchase transaction can proceed in a manner analogous to that shown in FIGS.", "17A-17D.", "FIGS.", "18A-18C are flow diagrams illustrating a method 1800 of managing automatic usage of a saved credential through enrolled fingerprints in accordance with some embodiments.", "The method 1800 is performed at an electronic device (e.g., device 300 of FIG.", "3, or portable multifunction device 100 of FIG.", "1A) with a display, a fingerprint sensor, and optionally, a touch-sensitive surface.", "In some embodiments, the display is a touch screen display and the touch-sensitive surface is on the display.", "In some embodiments, the display is separate from the touch-sensitive surface.", "In some embodiments, the fingerprint sensor is integrated with the touch-sensitive surface (e.g., the touch screen or the touch-sensitive surface separate from the display).", "In some embodiments the fingerprint sensor is separate from the touch-sensitive surface.", "Some operations in method 1800 are, optionally, combined and/or the order of some operations is, optionally, changed.", "As described below, the method 1800 provides an efficient and intuitive way of providing automatic usage of saved credentials through enrolled fingerprints while also providing security in light of possible unauthorized enrollment of new fingerprints.", "The method increases the security of using saved credentials, while permitting concurrent enrollment of multiple fingerprints on the device.", "As shown in FIG.", "18A, at an electronic device with one or more processors, memory, and a fingerprint sensor: the electronic device stores (1802) on the device a respective credential of a user of the device.", "In some embodiments, the respective credential includes (1804) a credential selected from the set consisting of: a user ID, a password, a credit card number, a bank account number, an address, a telephone number, and a shopping credential.", "For example, in some embodiments, as illustrated in FIGS.", "17A-17G, the respective credential is an account passcode for a registered shopping account at an online store (e.g., an app store or an e-commerce store).", "The online store uses the account passcode to identify and/or authenticate a shopper and/or retrieve previously stored customer information associated with the shopper.", "In some embodiments, the respective credential is a user ID associated with the device, a user ID associated with an email account, or a user ID associated with an online service account (e.g., online gaming account, a document storage account, etc.).", "In some embodiments, the respective credential includes a set of user information that is frequently used during online shopping, including a credit card number, a shipping address, a billing address, a credit card expiration date, a telephone number, and/or a credit card security code, etc.", "In some embodiments, the respective credential includes private authentication information used to verify the user's identity.", "In some embodiments, the respective credential further includes other user data (e.g., address, birthday, age, preferences, etc.)", "associated with the authentication information.", "In some embodiments, the respective credential is associated with a respective context (e.g., making a purchase using a shopping application, unlocking a locked screen, completing a credit card transaction on an e-commerce web site, etc.)", "for which it is applicable.", "In some embodiments, the device stores the respective credential in association with the respective context for which it is applicable, such that the device is able to retrieve and use the correct credential under a given context.", "In some embodiments, the device stores the respective credential in a secured form, e.g., an encrypted form.", "In some embodiments, the device automatically stores the respective credential entered by the user, when the user successfully uses the respective credential in context (e.g., using the account passcode for a registered online shopping account to complete a purchase transaction at an online store).", "In some embodiments, the device stores the respective credential through a respective credential set-up process initiated by the user.", "In some embodiments, the context for using the respective credential is associated with a software application executing on the electronic device (e.g., a shopping application, a browser application presenting an online shopping portal, a device operating system, a security application, an email application, a banking application, etc.).", "While executing a software application (1806) (e.g., while executing the software application with fingerprint authorization of automatic usage of the respective credential currently enabled on the device): the device receives (1808) a fingerprint at the fingerprint sensor of the device.", "In response to receiving the fingerprint and in accordance with a determination that credential-usage criteria have been satisfied, including a determination that the received fingerprint matches at least one of a set of enrolled fingerprints, the device automatically uses (1810) the respective credential of the user in the software application (e.g., without the user entering additional authorizing information other than the fingerprint).", "For example, in some embodiments, the user requests performance of a particular operation that is secured by the credential (e.g., logging in to a secured user interface of the application or making a purchase) and the credential is automatically provided to the application for use in performing the particular requested operation).", "For example, as illustrated in FIGS.", "17A-17D, in some embodiments, while executing a software application of an online store, the device determines that a respective credential (e.g., an account passcode) associated with the user is requested by the software application.", "The device determines whether the required credential is currently stored on the device, and if so, whether automatic usage of the stored credential through at least one of a set of enrolled fingerprints is currently enabled.", "As described with reference to method 600, automatic usage of saved credentials through enrolled fingerprints can be enabled by the user using a predefined fingerprint usage setting.", "If automatic usage of saved credentials through enrolled fingerprints is enabled, and the appropriate credential (e.g., the account passcode) is already stored on the device, the device prompts (e.g., using pop-up window 1710 in FIG.", "17B) the user to provide an enrolled fingerprint input, in lieu of providing the required credential itself.", "In some embodiments, the device temporarily activates the fingerprint sensor (e.g., fingerprint sensor 169 or 1712 in FIG.", "17C) to capture the fingerprint input provided by the user.", "The device receives a fingerprint input (e.g., fingerprint 1718 in FIG.", "17C) at the fingerprint sensor and checks whether the received fingerprint matches one of a set of fingerprints currently enrolled on the device.", "In some embodiments, the device presents a pop-up window that prompts the user to either provide a fingerprint input at the fingerprint sensor (i.e., to automatically use the saved credential) or to manually enter a credential that the user wishes to use for the current secured operation.", "For example, in some embodiments, activation of the fingerprint sensor is performed concurrently with presenting a soft keypad with a text input field for the user to enter the required credential directly.", "Providing these two choices concurrently to the user allows the user to easily enter a credential other than the one that has been saved on the device.", "In some embodiments, the determination that credential-usage criteria have been satisfied includes (1812) a determination that usage of the respective credential has not been disabled.", "For example, in some embodiments, automatic usage of the respective credential is optionally disabled when the total number of unsuccessful attempts to enter an enrolled fingerprint has exceeded a predetermined threshold number.", "In some embodiments, automatic usage of the respective credential is optionally disabled when an additional fingerprint has been enrolled since the respective credential was last used.", "In some embodiments, the device also maintains a cumulative counter for unmatched fingerprint inputs that have been provided thus far.", "In some embodiments, if the number of unmatched fingerprints exceeds a predetermined threshold number, the device disables automatic usage of saved credentials through fingerprints.", "For example, if the user provided more than a threshold number of unmatched fingerprints in response to the prompt for an enrolled fingerprint (e.g., the pop-up window 1710 in FIG.", "17C), automatic usage of the saved credential (e.g., the account passcode) will be disabled.", "In response, the device will present a different prompt asking the user to manually enter the required credential.", "In some embodiments, a determination that the received fingerprint matches at least one of a set of enrolled fingerprints further includes a determination that the received fingerprint matches any one of all fingerprints currently enrolled on the device.", "In some embodiments, a determination that the received fingerprint matches at least one of a set of enrolled fingerprints further includes a determination that the received fingerprint matches one of a subset of all fingerprints currently enrolled on the device, where the subset of enrolled fingerprints are one or more fingerprints specifically associated with the software application and/or the respective credential.", "In some embodiments, automatically using the respective credential in the software application includes automatically populating one or more text input fields provided in the software application using the respective credential.", "In some embodiments, automatically using the respective credential in the software application includes automatically sending the respective credential in a plain or encrypted form to the software application or to a remote server through the software application.", "For example, as illustrated in FIGS.", "17C-17D, the device provides the saved credential (e.g., the saved account passcode) to the online store through an app store application to complete a purchase transaction at the online store.", "After automatically using the respective credential of the user in response to receiving the fingerprint, the device receives (1814) a request to enroll an additional fingerprint with the device.", "In response to the request to enroll the additional fingerprint with the device, the device adds (1816) the additional fingerprint to the set of enrolled fingerprints.", "For example, as illustrated in FIGS.", "17D-17F, after the user had finished the shopping transaction using an enrolled fingerprint in lieu of manually entering the required account passcode, the user requested to register a new fingerprint on the device 100 and has enrolled an additional fingerprint (e.g., Finger 2 in FIG.", "17F) to the set of fingerprints currently enrolled on the device.", "In some embodiments, in response to adding the additional fingerprint to the set of enrolled fingerprints, the device prevents (1818) enrolled fingerprints from being used to authorize automatic usage of the respective credential.", "In some other embodiments, for enhanced security, the device prevents enrolled fingerprints from being used to authorize automatic usage of the respective credential in response to detecting a request to enroll an additional fingerprint with the device, independent of whether or not an additional fingerprint is actually enrolled.", "Thus, in some other embodiments, the mere request to enroll an additional fingerprint (e.g., activating “Add Finger” in FIG.", "17E) causes the device to prevent enrolled fingerprints from being used to authorize automatic usage of the respective credential (e.g., at least until the respective credential is subsequently entered manually).", "Disabling automatic usage of a saved credential after an attempt to enroll an additional fingerprint provides an alert to the user (either implicitly or explicitly) of the attempted enrollment.", "In some embodiments, the device stores (1820) on the device a predefined fingerprint usage setting that enables the device to automatically use the respective credential of the user in a software application upon receiving a fingerprint that matches at least one of a set of enrolled fingerprints.", "For example, exemplary embodiments of the predefined fingerprint usage setting for enabling automatic usage of saved credentials are described with reference to method 600.In some embodiments, preventing enrolled fingerprints from being used to authorize automatic usage of the respective credential includes (1822) deleting or changing a value of the predefined fingerprint usage setting.", "In some embodiments, deleting or changing a value of the predefined fingerprint usage setting includes deleting a previous authorization from the user to enable automatic usage of saved credentials through an enrolled fingerprint, or changing the fingerprint usage setting (e.g., Touch ID Purchase setting 550 in FIG.", "5U) from enabled to disabled.", "In some embodiments, preventing enrolled fingerprints from being used to authorize automatic usage of the respective credential includes (1824) deleting a predefined set of confidential values that includes the respective credential.", "For example, in some embodiments, the device deletes all saved credentials currently stored on the device, such that no saved credential is available for automatic use through enrolled fingerprints.", "In such embodiments, in the event that the user manually enters a credential in context, the device will automatically save the manually entered credential, and re-enable the automatic usage of the credential through enrolled fingerprints.", "In some embodiments, if the device supports different sets of enrolled fingerprints for usage of different sets of saved credentials, the device deletes all saved credentials associated with the respective set of enrolled fingerprints to which the additional fingerprint was added.", "In some embodiments, preventing enrolled fingerprints from being used to authorize automatic usage of the respective credential includes (1826) deleting the respective credential (e.g., deleting the Apple ID password in the example shown in FIGS.", "5A-5J).", "In some embodiments, the device deletes the respective credential along with one or more other saved credentials having the same level of security on the device.", "In some embodiments, the device keeps track of the number of unsuccessful attempts to provide an enrolled fingerprint to unlock the device.", "In some embodiments, if the device has registered too many failed attempts to unlock the device using an enrolled fingerprint, the device continues to keep the device locked, and also disables automatic usage of saved credentials through enrolled fingerprints.", "In such embodiments, even if the device is subsequently unlocked (e.g., through the use of an unlock passcode), the user is required to re-enable the automatic usage of save credentials by manually entering the saved credentials and/or reconfiguring the predefined fingerprint usage setting.", "In some embodiments, the device receives (1828) a sequence of N unsuccessful attempts to unlock the device via fingerprint authorization, wherein N is a predefined integer greater a predetermined threshold number (e.g., 1, 2, 3, 4, 5 or any reasonable number of unsuccessful attempts).", "In response to receiving the sequence of N unsuccessful attempts to unlock the device via fingerprint authorization, the device prevents (1830) enrolled fingerprints from being used to authorize automatic usage of the respective credential.", "In some embodiments, the device provides a way to reauthorize or re-enable the automatic usage of saved credentials through enrolled fingerprints, after the automatic usage has been prevented or disabled (e.g., through any of the methods described above).", "In some embodiments, after preventing enrolled fingerprints from being used to authorize automatic usage of the respective credential (1832): the device receives (1834) a request to use the respective credential in the software application (e.g., as shown in FIG.", "17G, the device receives a request from the app store application to use the account passcode to complete a purchase transaction).", "In the event that the automatic usage of the saved credential has been disabled, the device requests (1836) the respective credential from the user (e.g., by presenting the pop-up window 1730 and the soft keypad 1732, as shown in FIG.", "17H).", "The device receives (1838) the respective credential (e.g., the account passcode) from the user (e.g., through the text input field shown in the pop-up window 1730 in FIG.", "17I).", "In some embodiments, in response to receiving the respective credential from the user (1740): the device uses (1742) the respective credential in the software application (e.g., as illustrated in FIGS.", "17I-17J); and enables (1744) enrolled fingerprints to be used to authorize automatic usage of the respective credential.", "For example, in some embodiments, once the automatic usage of the respective credential is re-enabled, if the user returns to the same software application (e.g., the app store application), and tries to activate the same secured operation (e.g., making another purchase), the operation can proceed in a manner analogous to that shown in FIGS.", "17A-17D (i.e., the user can provide an enrolled fingerprint in lieu of the credential to complete the purchase).", "It should be understood that the particular order in which the operations in FIGS.", "18A-18C have been described is merely exemplary and is not intended to indicate that the described order is the only order in which the operations could be performed.", "One of ordinary skill in the art would recognize various ways to reorder the operations described herein.", "Additionally, it should be noted that details of other processes described herein with respect to other methods described herein (e.g., those listed in the “Description of Embodiments” section above) are also applicable in an analogous manner to method 1800 described above with respect to FIGS.", "18A-18C.", "For example, the finger inputs (e.g., including fingerprints), requests, operations, credentials, and requests described above with reference to method 1800 optionally have one or more of the characteristics of the finger inputs (e.g., including fingerprints), requests, operations, credentials, and requests described herein with reference to other methods described herein (e.g., those listed in the “Description of Embodiments” section above).", "For brevity, these details are not repeated here.", "In accordance with some embodiments, FIG.", "19 shows a functional block diagram of an electronic device 1900 configured in accordance with the principles of the various described embodiments.", "The functional blocks of the device are, optionally, implemented by hardware, software, or a combination of hardware and software to carry out the principles of the various described embodiments.", "It is understood by persons of skill in the art that the functional blocks described in FIG.", "19 are, optionally, combined or separated into sub-blocks to implement the principles of the various described embodiments.", "Therefore, the description herein optionally supports any possible combination or separation or further definition of the functional blocks described herein.", "As shown in FIG.", "19, an electronic device 1900 includes a display unit 1902 configured to display a graphic user interface, a touch-sensitive surface unit 1904 configured to receive contacts, a fingerprint sensor unit 1906 configured to receive a fingerprint input; and a processing unit 1908 coupled to the display unit 1902, the touch-sensitive surface unit 1904, and the fingerprint sensor unit 1906.In some embodiments, the processing unit 1908 includes a credential storage unit 1910, a determining unit 1912, a credential usage unit 1914, a fingerprint enrollment unit 1916, a usage authorization unit 1918, a settings storage unit 1920, a locking unit 1922, a request receiving unit 1924, and a credential receiving unit 1926.In some embodiments, the credential storage unit 1910 is configured to store on the device a respective credential of a user of the device.", "While a software application is being executed on the device: the fingerprint sensor unit 1906 is configured to receive a fingerprint at the fingerprint sensor of the device.", "The determining unit 1912 is configured to: while the software application is being executed on the device, determine that credential-usage criteria have been satisfied, including determining that the received fingerprint matches at least one of a set of enrolled fingerprints.", "The credential usage unit 1914 is configured to: while the software application is being executed on the device, in response to the receipt of the fingerprint by the fingerprint sensor unit 1906 and in accordance with a determination by the determining unit 1912 that credential-usage criteria have been satisfied, including a determination that the received fingerprint matches at least one of a set of enrolled fingerprints, automatically use the respective credential of the user in the software application.", "The fingerprint enrollment unit 1916 is configured to: after the credential usage unit 1914 has automatically used the respective credential of the user in response to the fingerprint sensor unit 1906 receiving the fingerprint, receive a request to enroll an additional fingerprint with the device.", "The fingerprint enrollment unit 1916 is further configured to: in response to the request to enroll the additional fingerprint with the device, add the additional fingerprint to the set of enrolled fingerprints.", "The usage authorization unit 1718 is configured to: in response to the addition of the additional fingerprint to the set of enrolled fingerprints by the fingerprint enrollment unit 1916, prevent enrolled fingerprints from being used to authorize automatic usage of the respective credential.", "In some embodiments, the determination that credential-usage criteria have been satisfied includes a determination that usage of the respective credential has not been disabled.", "In some embodiments, the respective credential includes a credential selected from the set consisting of: a user ID, a password, a credit card number, a bank account number, an address, a telephone number, and a shopping credential.", "In some embodiments, the settings storage unit 1920 is configured to store on the device a predefined fingerprint usage setting that enables the device to automatically use the respective credential of the user in the software application upon receiving a fingerprint that matches at least one of a set of enrolled fingerprints.", "In some embodiments, the usage authorization unit 1918 is configured to prevent enrolled fingerprints from being used to authorize automatic usage of the respective credential by deleting or changing a value of the predefined fingerprint usage setting.", "In some embodiments, the usage authorization unit 1918 is configured to prevent enrolled fingerprints from being used to authorize automatic usage of the respective credential by deleting a predefined set of confidential values that includes the respective credential.", "In some embodiments, the usage authorization unit 1918 is configured to prevent enrolled fingerprints from being used to authorize automatic usage of the respective credential by deleting the respective credential.", "In some embodiments, the locking unit 1922 is configured to: receive a sequence of N unsuccessful attempts to unlock the device via fingerprint authorization, wherein N is a predefined integer; and in response to receiving the sequence of N unsuccessful attempts to unlock the device via fingerprint authorization, prevent enrolled fingerprints from being used to authorize automatic usage of the respective credential.", "In some embodiments, the request receiving unit 1924 is configured to receive a request to use the respective credential in the software application, after enrolled fingerprints are prevented from being used to authorize automatic usage of the respective credential.", "The credential receiving unit 1926 is configured to requesting the respective credential from the user (e.g., after the request receiving unit 1924 receives the request and enrolled fingerprints are prevented from being used to authorize automatic usage of the respective credential).", "In some embodiments, the credential usage unit 1914 is further configured to: in response to the credential receiving unit receiving the respective credential from the user, use the respective credential in the software application.", "In addition, in some embodiments, the usage authorization unit 1918 is further configured to: in response to the credential receiving unit receiving the respective credential from the user, enable enrolled fingerprints to be used to authorize automatic usage of the respective credential.", "The operations in the information processing methods described above are, optionally implemented by running one or more functional modules in information processing apparatus such as general purpose processors (e.g., as described above with respect to FIGS.", "1A and 3) or application specific chips.", "The operations described above with reference to FIGS.", "18A-18J are, optionally, implemented by components depicted in FIGS.", "1A-1B or FIG.", "19.For example, storing operation 1802, receiving operation 1808, using operation 1810, adding operation 1816, preventing operation 1818 are, optionally, implemented by event sorter 170, event recognizer 180, and event handler 190.Event monitor 171 in event sorter 170 detects a contact on touch-sensitive display 112, and event dispatcher module 174 delivers the event information to application 136-1.A respective event recognizer 180 of application 136-1 compares the event information to respective event definitions 186, and determines whether a first contact at a first location on the touch-sensitive surface corresponds to a predefined event or sub-event, such as selection of an object on a user interface.", "When a respective predefined event or sub-event is detected, event recognizer 180 activates an event handler 190 associated with the detection of the event or sub-event.", "Event handler 190 optionally utilizes or calls data updater 176 or object updater 177 to update the application internal state 192.In some embodiments, event handler 190 accesses a respective GUI updater 178 to update what is displayed by the application.", "Similarly, it would be clear to a person having ordinary skill in the art how other processes can be implemented based on the components depicted in FIGS.", "1A-1B.", "Revealing Redacted Information Many electronic devices have graphical user interfaces that contain private information (e.g., information that a user of the device may not want to be viewed by others).", "Redacting private information prevents other people from viewing the private information; however, redacting private information also prevents the user of the device from viewing the private information.", "Some methods require a user to perform a complicated sequence of steps (e.g., navigating to a settings menu and/or entering a pass code or password) to reveal redacted information (e.g., by unlocking the device or changing redaction settings).", "This makes it difficult and time consuming for the user to quickly review an unredacted version of the information.", "Thus, it would be advantageous to provide a way for a user to quickly and intuitively remove redaction from information displayed by the device so that the private information is hidden from other people but is still readily accessible to the user of the device.", "In some embodiments described below, an improved method for revealing redacted information is achieved by using a fingerprint sensor to determine whether or not to reveal redacted information.", "In particular, while the device is displaying information with a redacted portion, the device determines whether or not to display an unredacted version of the redacted portion of the information based on whether the device detects a fingerprint that matches a previously enrolled fingerprint on a fingerprint sensor of the device.", "This method streamlines the process of revealing redacted information by enabling a user to reveal redacted information simply by placing a finger on a fingerprint sensor of the device, thereby eliminating the need for extra, separate, steps to reveal redacted information.", "In some embodiments, the device is an electronic device with a separate display (e.g., display 450) and a separate touch-sensitive surface (e.g., touch-sensitive surface 451).", "In some embodiments, the device is portable multifunction device 100, the display is touch screen 112, and the touch-sensitive surface includes tactile output generators 167 on the display (FIG.", "1A).", "The device described below with reference to 20A-20T and 21A-21C includes one or more fingerprint sensors 169.In some embodiments, the one or more fingerprint sensors include one or more integrated fingerprint sensors 359-1 (FIG.", "4B) that are integrated in to the touch-sensitive surface (e.g., separate touch-sensitive surface 451 or touch sensitive display system 112).", "In some embodiments, the one or more fingerprint sensors include separate fingerprint sensors 359-2 (FIG.", "4B) that are separate from the touch-sensitive surface (e.g., separate touch-sensitive surface 451 or touch sensitive display system 112).", "Unless specified otherwise, a fingerprint sensor 169 described below is, optionally, either an integrated fingerprint sensor 359-1 or a separate fingerprint sensor 359-2, depending on the configuration of the hardware and software of the device that includes the fingerprint sensor 169.For convenience of explanation, the embodiments described with reference to FIGS.", "20A-20T and 21A-21C will be discussed with reference to a device with a touch screen 112 and a separate fingerprint sensor 359-2, however analogous operations are, optionally, performed on a device with an integrated fingerprint sensor 359-1 in response to detecting the inputs described in FIGS.", "20A-20T on the integrated fingerprint sensor 359-1 while displaying the user interfaces shown in FIGS.", "20A-20T on the display 450.Additionally, analogous operations are, optionally, performed on a device with a display 450 and a separate touch-sensitive surface 451 instead of a touch screen 112 in response to detecting the contacts described in FIGS.", "20A-20T on a fingerprint sensor 169 (e.g., an integrated fingerprint sensor 359-1 or a separate fingerprint sensor 359-2) and/or the separate touch-sensitive surface 451 while displaying the user interfaces shown in FIGS.", "20A-20T on the display 450; in such embodiments, the contacts shown in FIGS.", "20A-20T optionally represent both a focus selector that corresponds to a location on the display 450, and a contact that corresponds to a location of a contact or gesture performed on the separate touch-sensitive surface (e.g., touch-sensitive surface 451), where the focus selector is, optionally: a respective contact, a representative point corresponding to a contact (e.g., a centroid of a respective contact or a point associated with a respective contact), or a centroid of two or more contacts detected on the touch screen 112 and is, optionally, replaced with a displayed cursor.", "FIG.", "20A illustrates a locked-device user interface displayed on touch screen 112 of device 100 while the device is in a locked mode of operation.", "In some embodiments, locked-device user interface is displayed while one or more functions of device 100 are locked (e.g., access to personal data and applications is limited compared to when the device is in an unlocked mode of operation).", "In some embodiments, when the device detects a swipe gesture including movement of a contact from left to right across touch screen 112, the device is unlocked or an unlock sequence is initiated (e.g., a user is prompted to enter a pass code, as shown in FIG.", "20G).", "In some embodiments, the device is unlocked when the swipe gesture is detected over an unlock image 2001 (e.g., the text “>slide to unlock” in FIG.", "20A).", "In FIG.", "20B, while the device is in the locked mode of operation, the device receives an email and generates notification 2002 that includes redacted portion 2004 that corresponds to a snippet of content of the email and unredacted portion 2006 that includes a sender, title, and time of the email.", "In FIG.", "20C, the device detects a finger gesture that includes finger contact 2008 on fingerprint sensor 169.Finger contact 2008 includes a fingerprint that matches a previously enrolled fingerprint and, in response to detecting finger contact 2008, the device displays unredacted version 2010 of the content of the email.", "In this example, the device continues to display unredacted portion 2006 of notification 2002 while displaying unredacted version 2010 of the content.", "FIG.", "20D illustrates a locked-device user interface displayed on touch screen 112 of device 100 while the device is in a locked mode of operation after the device has generated multiple notifications that correspond to different received communications or events, including a compressed version 2012-4 of email notification 2002 shown in FIGS.", "20B-20C, calendar notification 2012-1, phone call notification 2012-2, and email notification 2012-3.In FIG.", "20D, the content of email notifications 2012-3 and 2012-4 is redacted and the name of the caller in phone call notification 2012-2 is redacted, while none of the information in calendar notification 2012-1 is redacted.", "In some embodiments a name or location of the calendar notification is redacted.", "In some embodiments, none of the information in phone call notification 2012-2 is redacted.", "In some embodiments, one or more of these notifications 2012 in FIG.", "20D includes only redacted information.", "In FIGS.", "20E-20F, the device detects contact 2020 on touch screen 112 and detects movement 2022-a and 2022-b of contact 2020 across touch screen 112.In response to detecting contact 2020 at or near a location of icon 2024 that corresponds to email notification 2012-3, the device ceases to display descriptive information about email notification 2012-3 (e.g., the redacted and unredacted information that correspond to the notification) and instead displays an instruction for accessing the email corresponding to the notification (e.g., “slide to unlock” 2026).", "In response to detecting movement of contact 2020, the device moves icon 2024 across the display (e.g., so as provide visual confirmation that the notification that corresponds to icon 2024 has been selected and/or to indicate progress toward unlocking the device and displaying the email corresponding to email notification 2012-3).", "In some embodiments, when at least a portion of a respective notification is redacted, the device responds to an attempt to unlock the device to access additional information related to the respective notification (e.g., swipe gesture at a location that corresponds to the respective notification, as shown in FIGS.", "20E-20F) by requesting additional authentication from the user (e.g., as shown in FIG.", "20G).", "In some embodiments, when a respective notification is not redacted, the device responds to an attempt to unlock the device to access additional information related to the respective notification (e.g., swipe gesture at a location that corresponds to the respective notification, as shown in FIGS.", "20J-20K) by displaying the additional information related to the respective notification (e.g., as shown in FIG.", "20L).", "In FIG.", "20G, the device displays an unlock user interface for unlocking the device.", "In FIG.", "20G, the device will unlock the device in response to detecting entry of a pass code for the device or in response to detecting a fingerprint on fingerprint sensor 169 that matches a previously enrolled fingerprint.", "For example, if a correct pass code is entered in pass code entry user interface 2028 (e.g., by detecting tap gestures on the numbers that correspond to entry of the correct pass code) and/or a fingerprint matching a previously enrolled fingerprint is detected on fingerprint sensor 169, the device will display a copy of the email that corresponds to the activated notification 2012-3 in FIG.", "20D in an email application (e.g., as shown in FIG.", "20L).", "In FIG.", "20H, the device displays unredacted versions of previously redacted notifications in response to detecting finger contact 2030 on fingerprint sensor 169 that includes a fingerprint that matches a previously enrolled fingerprint while displaying multiple notifications 2012, a plurality of which included both redacted and unredacted information (e.g., as shown in FIG.", "20D).", "In this example, the device continues to display the unredacted portions of notifications 2012 while displaying unredacted portions of a plurality of notifications that previously included redacted portions (e.g., notifications 2012-2, 2012-3, and 2012-4 previously included redacted portions in FIG.", "20D and do not include redacted portions in FIG.", "20H after finger contact 2030 has been detected).", "In some embodiments, in response to detecting liftoff of finger contact 2030, redacted versions of the notifications are redisplayed (e.g., returning to the user interface shown in FIG.", "20D).", "In some embodiments, in response to detecting liftoff of finger contact 2030, the device is unlocked (e.g., as shown in FIG.", "20I).", "In some embodiments, after detecting liftoff of the finger contact 2030, the unredacted versions of the notifications continue to be displayed for a predefined time period (e.g., for 5, 10, 15, 30, 60 seconds or some other reasonable time period) or until a predetermined criteria has been met (e.g., the display of the device has turned off either due to a screen-dim timer or due to a screen-dim input from a user such as activating a sleep/power button of the device), as shown in FIG.", "20J, where unredacted versions of notifications 2012-2 and 2012-4 are displayed even though the device is not currently detecting a fingerprint on fingerprint sensor 169.In FIG.", "20I, in response to detecting a liftoff of finger contact 2030 (FIG.", "20H) from fingerprint sensor 169, the device transitions from operating in a locked mode to operating in an unlocked mode and displays an application launch interface for launching a plurality of different applications (e.g., in response to detecting a tap gesture on a respective icon of the icons displayed on touch screen 112 in FIG.", "20I, the device would open an application corresponding to the respective icon as described in greater detail above with reference to FIG.", "4A).", "In some embodiments, when the device is unlocked, a most recently open application (e.g., an application that was open at the time when the device was locked) is displayed instead of displaying the application launch user interface (e.g., if a mail application was open when the device was last locked, a mail application user interface such as the interface shown in FIG.", "20L is shown on the display).", "In FIGS.", "20J-20K, while unredacted versions of notifications 2012 are displayed (e.g., as shown in FIG.", "20H), the device detects contact 2032 on touch screen 112 and movement 2034-a and 2034-b of contact 2032 across touch screen 112.In response to detecting contact 2032 at or near a location of an icon 2024 that corresponds to email notification 2012-3, the device ceases to display descriptive information about email notification 2012-3 (e.g., the redacted and unredacted information that correspond to the notification) and instead displays an instruction for accessing the email corresponding to the notification (e.g., “slide to unlock” 2026).", "In response to detecting movement of contact 2032, the device moves icon 2024 across the display (e.g., so as provide visual confirmation that the notification that corresponds to icon 2024 has been selected and/or to indicate progress toward unlocking the device and displaying the email corresponding to email notification 2012-3).", "In FIG.", "20L, the device displays an email received at the device that corresponds to notification 2012-3 in FIGS.", "20D and 20H.", "As shown in FIG.", "20L, the full version of the email includes additional content that is not included in the snippet shown in the notification that corresponds to the email.", "The email interface in FIG.", "20L also includes a plurality of controls 2036 that enable the user to perform or initiate performance of different operations, such as: navigate to different emails (e.g., by tapping on control 2036-1 to display an inbox view that includes representations of a plurality of emails, by tapping on control 2036-3 to navigate to a previous email in the current folder or tapping on control 2036-2 to navigate to a next email in the current folder), flag/star the displayed email (e.g., by tapping on control 2036-4), file the displayed email in a folder (e.g., by tapping on control 2036-5), delete/archive the displayed email (e.g., by tapping on control 2036-6), reply/forward the displayed email (e.g., by tapping on control 2036-7), and draft a new email (e.g., by tapping on control 2036-8).", "In FIGS.", "20M-20O, the device detects contact 2040 on touch screen 112 and movement 2042-a and 2042-b across touch screen 112.In response to detecting movement of contact 2040 downward from a top edge of touch screen 112, the device gradually displays notification interface 2044 sliding down touch screen 112, e.g., in accordance with movement 2042 of contact 2040.As shown in FIG.", "20P, notification interface 2044 includes a plurality of notifications that include redacted information and unredacted information and a plurality of notifications that include only unredacted information.", "In FIG.", "20P, calendar notifications 2046-1 and 2046-2 are unredacted; email notifications 2046-3 and 2046-4 include unredacted senders, subjects and times and redacted content; phone message notifications 2046-5 and 2046-6 include redacted callers and unredacted times; and message notifications 2046-7 and 2046-8 include unredacted senders and times and redacted content.", "In FIG.", "20P, in response to detecting an upward swipe gesture including detecting contact 2048 near a lower edge of touch screen 112 and movement 2050 of contact 2048 upward on touch screen 112 while the redacted version of some of the notifications is displayed (e.g., as shown in FIG.", "20P), the device returns to displaying a locked-device user interface such as the user interface shown in FIG.", "20M.", "In FIG.", "20Q, in response to detecting finger contact 2052 on fingerprint sensor 169 that includes a fingerprint that matches a previously enrolled fingerprint, the device displays unredacted versions of multiple, previously redacted notifications 2046, a plurality of which include both redacted and unredacted information (e.g., as shown in FIG.", "20P).", "In this example, the device continues to display the unredacted portions of notifications 2046 while displaying unredacted portions of a plurality of notifications that previously included redacted portions (e.g., notifications 2046-3, 2046-4, 2046-5, 2046-6, 2046-7, and 2046-8 previously included redacted portions in FIG.", "20P and do not include redacted portions in FIG.", "20Q after finger contact 2052 has been detected).", "In some embodiments, in response to detecting liftoff of finger contact 2052, redacted versions of the notifications are redisplayed (e.g., returning to the user interface shown in FIG.", "20P).", "In some embodiments, in response to detecting liftoff of finger contact 2052, the device is unlocked (e.g., as shown in FIG.", "20I).", "In some embodiments, after detecting liftoff of the finger contact 2030, the unredacted versions of the notifications continue to be displayed for a predefined time period (e.g., for 5, 10, 15, 30, 60 seconds or some other reasonable time period) or until a predetermined criteria has been met (e.g., the display of the device has turned off either due to a screen-dim timer or due to a screen-dim input from a user such as activating a sleep/power button of the device).", "In FIG.", "20Q, in response to detecting an upward swipe gesture including detecting contact 2054 near a lower edge of touch screen 112 and movement 2056 upward on touch screen 112 as shown in FIG.", "20Q while the unredacted versions the notifications are displayed, the device displays an unlocked-device user interface (e.g., an application launch user interface such as the application launch user interface shown in FIG.", "20I or a user interface for a recently opened application such as the email user interface shown in FIG.", "20L).", "FIGS.", "20R-20T illustrate alternative ways to redact a notification.", "In FIG.", "20R, a snippet of content is replaced with redaction text string 2058 (e.g., <Message Content>) that indicates that the snippet of content of the email has been redacted.", "In FIG.", "20S, a snippet of content of the email is obscured by placing black boxes 2060 over individual words to indicate that the snippet of content of the email has been redacted.", "In FIG.", "20T, predefined redaction object 2062 has been placed over the snippet of content to indicate that the snippet of content of the email has been redacted.", "While the redaction shown in FIGS.", "20A-20Q included blurring redacted text, any suitable method of rendering the redacted content unreadable, including those shown in FIGS.", "20R-20T, could be used instead of or in addition to the blurring shown in FIGS.", "20A-20Q.", "FIGS.", "21A-21C are flow diagrams illustrating a method 2100 of revealing redacted information in accordance with some embodiments.", "The method 2100 is performed at an electronic device (e.g., device 300, FIG.", "3, or portable multifunction device 100, FIG.", "1A) with a display and a touch-sensitive surface.", "In some embodiments, the display is a touch screen display and the touch-sensitive surface is on the display.", "In some embodiments, the display is separate from the touch-sensitive surface.", "Some operations in method 2100 are, optionally, combined and/or the order of some operations is, optionally, changed.", "As described below, the method 2100 provides an intuitive way to reveal redacted information.", "The method reduces the cognitive burden on a user when revealing redacted information, thereby creating a more efficient human-machine interface.", "For battery-operated electronic devices, enabling a user to revealing redacted information faster and more efficiently conserves power and increases the time between battery charges.", "In some embodiments, the device displays (2102) a locked-device user interface.", "In some embodiments, the device receives (2104) a request to display information (e.g., detecting the activation of a button that corresponds to a request to turn on a display of the device, or detecting a request to display a notification user interface as shown in FIGS.", "20M-20P).", "In some embodiments, the device detects (2106) the occurrence of a predefined event (e.g., the device receives a new communication and generates a notification of the new communication as described above with reference to FIGS.", "20A-20B).", "The device displays (2108) a redacted version of first information on the display (e.g., notification 2002 in FIG.", "20B, notifications 2012-2, 2012-3, 2012-4 in FIG.", "20D, or notifications 2046-3, 2046-4, 2046-5, 2046-6, 2046-7, 2046-8 in FIG.", "20P).", "In some embodiments, the redacted version of the first information is displayed in response to receiving the request to display information and/or in response to detecting the occurrence of the predefined event.", "In some embodiments, the first redacted information includes (2110) a plurality of distinct information items (e.g., notifications 2012-2, 2012-3, 2012-4 in FIG.", "20D, or notifications 2046-3, 2046-4, 2046-5, 2046-6, 2046-7, 2046-8 in FIG.", "20P), and each information item in the plurality of information items includes a redacted portion and an unredacted portion (e.g., in FIG.", "20D, the time and description of phone call notification 2012-2 are not redacted, while the name of the caller is redacted, and the subject, sender and time of email notifications 2012-3 and 2012-4 are not redacted while the content of the emails is redacted).", "In some embodiments, an information item is a set of related information (e.g., information related to a single event or communication).", "For example, an information item for an electronic message includes two or more of: a name of a sender, a subject line, a time at which the message was received, and content of the message.", "As another example, an information item for a calendar event includes two or more of a name of an event, a list of participants, a location, a time of the event, and a description of the event.", "As another example, an information item for a phone call includes two or more of a name of a caller, a phone number from which the phone call was received, and a time of the call.", "In some embodiments, the first information includes (2112) a notification that includes identifying information (e.g., a sender of a message and a time) and content (e.g., a subject line and/or a snippet or portion of a body of a message), the identifying information is not redacted and the content is redacted (e.g., as shown with notification 2002 in FIG.", "20B and notifications 2012-3 and 2014 in FIG.", "20D).", "In some embodiments, the first information includes (2114) one or more notifications of communications received by the device (e.g., notifications of missed messages, emails, phone calls and the like).", "For example, in FIG.", "20D, the first information includes phone call notification 2012-2 and email notifications 2012-3 and 2012-4.In some embodiments, the first information includes (2116) one or more notifications of social networking updates.", "(e.g., notifications of messages and events generated by users who are friends or are followed by a user of the device).", "In some embodiments, the redacted version of the first information includes (2118) a copy of the first information that has been rendered unreadable (e.g., by blurring words as shown in FIGS.", "20B, 20D and 20P, by blacking out words as shown in FIG.", "20S, or by otherwise obscuring text).", "In some embodiments, the redacted version of the first information includes (2120) a predefined redaction object (e.g., a string that says <message content> as shown in FIG.", "20R or <redacted content> or a predefined shape as shown in FIG.", "20T) that is displayed in place of text in the first information.", "In some embodiments, the redacted version of the first information is displayed (2122) on a locked-device user interface (e.g., a lock screen) of the device (e.g., as shown in FIGS.", "20B and 20D).", "In some embodiments, the first information includes (2124) a plurality of distinct information items that are redacted (e.g., a plurality of notifications for different messages or events that occurred on the device).", "In some embodiments, information items in a plurality of information items in the first information each include a redacted portion (e.g., content) and an unredacted portion (e.g., an identifier).", "For example in FIG.", "20D, notifications 2012-2, 2012-3, and 2012-4 each include a redacted portion and an unredacted portion and in FIG.", "20P, notifications 2046-3, 2046-4, 2046-5, 2046-6, 2046-7, 2046-8 each include a redacted portion and an unredacted portion.", "In some embodiments, while displaying the redacted version of the first information, the device displays (2128) an unredacted version of second information (e.g., in FIG.", "20D, notification 2012-1 is unredacted and in FIG.", "20P, notifications 2046-1 and 2046-2 are unredacted).", "In some embodiments, the device displays a plurality of notifications including one or more redacted notifications and one or more unredacted notifications (e.g., notifications of email messages are redacted, while notifications from a game are not redacted).", "Providing a plurality of notifications that each include a redacted portion and an unredacted portion provides the user with the ability to quickly view at least some information about multiple different events or communications and determine whether or not it is necessary to view the unredacted versions of the notifications and/or unlock the device to display additional information that corresponds to the notifications.", "Thus, providing a plurality of notifications with both redacted and unredacted content maintains the ease of use of the device for the user while improving the security of private information (e.g., content of email messages, content of text messages, and/or the identity of callers).", "While displaying the redacted version of the first information on the display, the device detects (2130) a finger input (e.g., finger contact 2008 in FIG.", "20C, finger contact 2030 in FIG.", "20H, or finger contact 2052 in FIG.", "20Q) on the fingerprint sensor (e.g., fingerprint sensor 169 in FIGS.", "20A-20T).", "In response (2132) to detecting the finger input on the fingerprint sensor, in accordance with a determination that the finger input includes a fingerprint that matches a previously enrolled fingerprint that is authorized to reveal the first information, the device replaces (2134) display of the redacted version of the first information with an unredacted version of the first information (e.g., as shown in FIGS.", "20B-20C, FIGS.", "20D and 20H, and FIGS.", "20P-20Q the device removes redaction from one or more notifications in response to detecting an enrolled fingerprint on fingerprint sensor 169).", "In some embodiments, when the first redacted information includes a plurality of distinct information items; and each information item in the plurality of information items includes a redacted portion and an unredacted portion, replacing display of the redacted version of the first information with the unredacted version of the first information includes (2136) replacing display of redacted portions of the plurality of information items with corresponding unredacted content while maintaining display of unredacted portions of the plurality of information items.", "For example in FIG.", "20D, notifications 2012-2, 2012-3, and 2012-4 each include a redacted portion and an unredacted portion and in FIG.", "20H, after detecting finger contact 2030 on fingerprint sensor 169, the redacted portions of these notifications are replaced with unredacted portions while the previously unredacted portions continue to be displayed.", "Similarly, in FIG.", "20P, notifications 2046-3, 2046-4, 2046-5, 2046-6, 2046-7, 2046-8 each include a redacted portion, and in FIG.", "20Q, after detecting finger contact 2052 on fingerprint sensor 169, the redacted portions of these notifications are replaced with unredacted portions while the previously unredacted portions continue to be displayed.", "In response to detecting the finger input on the fingerprint sensor, in accordance with a determination that the finger input does not include a fingerprint that matches a previously enrolled fingerprint that is authorized to reveal the first information, the device maintains (2138) display of the redacted version of the first information on the display.", "For example, if finger contact 2008 (FIG.", "20C) did not include a fingerprint that matched a previously enrolled fingerprint, the device would continue to display the user interface shown in FIG.", "20B (rather than the user interface shown in FIG.", "20C) or display a fingerprint match error user interface indicating to the user that a non-matching fingerprint was detected.", "As another example, if finger contact 2030 (FIG.", "20H) did not include a fingerprint that matched a previously enrolled fingerprint, the device would continue to display the user interface shown in FIG.", "20D (rather than the user interface shown in FIG.", "20H) or display a fingerprint match error user interface indicating to the user that a non-matching fingerprint was detected.", "As another example, if finger contact 2052 (FIG.", "20Q) did not include a fingerprint that matched a previously enrolled fingerprint, the device would continue to display the user interface shown in FIG.", "20P (rather than the user interface shown in FIG.", "20Q) or display a fingerprint match error user interface indicating to the user that a non-matching fingerprint was detected.", "Maintaining display of the redacted version of information when non-enrolled fingerprint is detected on the fingerprint sensor prevents unauthorized users from viewing private information that is redacted.", "In some embodiments, after displaying the unredacted version of the first information, the device continues (2140) to detect the fingerprint on the fingerprint sensor.", "In some embodiments, while continuing to detect the fingerprint on the fingerprint sensor, the device maintains (2142) display of the unredacted version of the first information on the display.", "In some embodiments, while maintaining display of the unredacted version of the first information, the device ceases (2144) to detect the fingerprint on the fingerprint sensor (e.g., detecting liftoff of the fingerprint from the fingerprint sensor).", "In some embodiments, in response to ceasing to detect the fingerprint on the fingerprint sensor, the device redisplays (2146) the redacted version of the first information.", "For example, in FIG.", "20C, if the device detected liftoff of contact 2008, the device would redisplay the user interface shown in FIG.", "20B.", "As another example, in FIG.", "20H, if the device detected liftoff of contact 2030, the device would redisplay the user interface shown in FIG.", "20D.", "As another example, in FIG.", "20Q, if the device detected liftoff of contact 2052, the device would redisplay the user interface shown in FIG.", "20P.", "In some embodiments, prior to detecting the first input, the device displays (2102) a locked-device user interface on the display (e.g., a user interface that corresponds to a locked mode of operation of the device as shown in FIG.", "20D).", "In some embodiments, after displaying the unredacted version of the first information, the device continues (2140) to detect the fingerprint on the fingerprint sensor (e.g., as shown in FIG.", "20H).", "In some embodiments, while continuing to detect the fingerprint on the fingerprint sensor, the device maintains (2142) display of the unredacted version of the first information on the display (e.g., as shown in FIG.", "20H).", "In some embodiments, while maintaining display of the unredacted version of the first information, the device ceases (2144) to detect the fingerprint on the fingerprint sensor (e.g., detecting liftoff of the fingerprint from the fingerprint sensor as shown in FIG.", "20I).", "In some embodiments, in response to ceasing to detect the fingerprint on the fingerprint sensor, the device ceases (2148) to display the first information; and displays an unlocked-device user interface on the display (e.g., displaying a user interface that corresponds to an unlocked mode of operation of the device such as the application launch user interface shown in FIG.", "20I or a user interface for a last-used application such as the mail application user interface shown in FIG.", "20L).", "Thus, in some embodiments, in response to detecting a finger-down portion of the first input, the device reveals redacted content (e.g., by replacing a redacted version of the content with an unredacted version of the content) and in response to detecting a finger-up portion of the first input, the device displays an unlocked-device user interface.", "Revealing redacted information in response to detecting a finger-down portion of a finger input and displaying an unlocked-device user interface in response to a finger-up portion of the finger input provides the user with a quick way to view the redacted content and then transition to the unlocked-device user interface.", "In some embodiments, the unlocked-device user interface is displayed in response to detecting liftoff of the finger contact if the time between the finger-down portion of the finger input (e.g., the time at which the finger was detected on the fingerprint sensor) and the finger-up portion of the finger input (e.g., the time at which the finger ceased to be detected on the fingerprint sensor) is greater than a first time threshold (e.g., 0.05, 0.1, 0.2, 0.5, 1 second, or some other reasonable time threshold); and the locked-device user interface continues to be displayed in response to detecting liftoff of the finger contact if the time between the finger-down portion of the finger input and the finger-up portion of the finger input is less than the first time threshold (e.g., the user can cancel the device unlock operation by removing the finger contact on the fingerprint sensor before the first time threshold amount of time has elapsed).", "In some embodiments, the unlocked-device user interface is displayed in response to detecting liftoff of the finger contact if the time between the finger-down portion of the finger input (e.g., the time at which the finger was detected on the fingerprint sensor) and the finger-up portion of the finger input (e.g., the time at which the finger ceased to be detected on the fingerprint sensor) is less than a second time threshold (e.g., 0.05, 0.1, 0.2, 0.5, 1 second, or some other reasonable time threshold); and the locked-device user interface continues to be displayed in response to detecting liftoff of the finger contact if the time between the finger-down portion of the finger input and the finger-up portion of the finger input is greater than the second time threshold (e.g., the user can cancel the device unlock operation by maintaining the finger contact on the fingerprint sensor for more than the second time threshold amount of time).", "In some embodiments, prior to displaying the redacted version of the first information, the device receives (2104) a request to display the first information.", "For example, the device detects a swipe gesture in a first direction (e.g., downward) starting at or near a first (e.g., top) edge of the display (e.g., as shown in FIGS.", "20M-20O, where contact 2040 is detected near a top edge of touch screen 112 and moves 2042 downward) or detects a predefined input (e.g., activation of a button of the device that corresponds to a request to wake the device from a low power mode, a request to turn the display of the device on, and/or a request to display a locked-device user interface).", "In some embodiments, in response to receiving the request to display the first information, the device displays (2108) the redacted version of the first information on the display.", "For example, in FIG.", "20P, the device displays notification user interface 2044 with a plurality of notifications 2046-3, 2046-4, 2046-5, 2046-6, 2046-7, 2046-8 that each include a redacted portion in response to detecting the swipe gesture in the first direction.", "In some embodiments, after displaying the first information, the device detects a swipe gesture (e.g., movement 2050 of contact 2048 in FIG.", "20P or movement 2056 of contact 2054 in FIG.", "20Q) in a second direction (e.g., upward) that is different from the first direction and starts at or near a different (e.g., bottom) edge of the display.", "In response to detecting the swipe gesture in the second direction, the device ceases to display the redacted version of the first information on the display.", "In some embodiments, whether or not the first information (e.g., the notifications in notification user interface 2044) is redacted depends on whether the device is in a locked mode of operation or an unlocked mode of operation (e.g., in response to detecting a request to display the first information while the device is a locked mode of operation), the device displays a redacted version of the first information such as the redacted notifications 2046-3, 2046-4, 2046-5, 2046-6, 2046-7, 2046-8 shown in FIG.", "20P, whereas in response to detecting a request to display the first information while the device is in an unlocked mode of operation, the device displays an unredacted version of the first information such as the unredacted notifications 2046-3, 2046-4, 2046-5, 2046-6, 2046-7, 2046-8 shown in FIG.", "20Q).", "In some embodiments, prior to displaying the redacted version of the first information, the device detects (2106) the occurrence of a predefined event and in response to detecting the occurrence of the predefined event, the device displays (2108) the redacted version of the first information on the display (e.g., in response to receiving a communication such as an email or a phone call, detecting that a reminder time for a calendar appointment has been reached, or receiving a notification from a third party application, the device displays a pop-up notification that corresponds to the event).", "For example, in FIG.", "20B, the device receives an email from Johnny Appleseed, generates a notification including information from the email and displays a redacted version of notification 2002 on touch screen 112.In some embodiments, whether or not the first information is redacted depends on whether the device is in a locked mode of operation or an unlocked mode of operation (e.g., in response to detecting the occurrence of the predefined event while the device is a locked mode of operation, the device displays a redacted version of the first information as shown in FIG.", "20B and in response to detecting the occurrence of the predefined event while the device is in an unlocked mode of operation, the device displays an unredacted version of the first information).", "In some embodiments, the redacted version of the first information is displayed in a predefined location on the display (e.g., in a center of the display) when it is first received and is later displayed in a list of notifications with one or more other notifications (e.g., one or more unredacted notifications and/or one or more redacted notifications).", "For example, in FIG.", "20B a notification 2002 for an email from Johnny Appleseed is initially displayed in a center of touch screen 112 in FIG.", "20B after it is received and notification 2012-4 for the same email from Johnny Appleseed is later displayed in FIG.", "20D in a list of other notifications generated by the device (e.g., notifications that correspond to communications received or events that occurred since the last time the device was unlocked) on touch screen 112.It should be understood that the particular order in which the operations in FIGS.", "21A-21C have been described is merely exemplary and is not intended to indicate that the described order is the only order in which the operations could be performed.", "One of ordinary skill in the art would recognize various ways to reorder the operations described herein.", "Additionally, it should be noted that details of other processes described herein with respect to other methods described herein (e.g., those listed in the “Description of Embodiments” section above) are also applicable in an analogous manner to method 2100 described above with respect to FIGS.", "21A-21C.", "For example, the fingerprints, contacts, gestures, redaction, and animations described above with reference to method 2100 optionally have one or more of the characteristics of the fingerprints, contacts, gestures, redaction, and animations described herein with reference to other methods described herein (e.g., those listed in the “Description of Embodiments” section above).", "For brevity, these details are not repeated here.", "In accordance with some embodiments, FIG.", "22 shows a functional block diagram of an electronic device 2200 configured in accordance with the principles of the various described embodiments.", "The functional blocks of the device are, optionally, implemented by hardware, software, or a combination of hardware and software to carry out the principles of the various described embodiments.", "It is understood by persons of skill in the art that the functional blocks described in FIG.", "22 are, optionally, combined or separated into sub-blocks to implement the principles of the various described embodiments.", "Therefore, the description herein optionally supports any possible combination or separation or further definition of the functional blocks described herein.", "As shown in FIG.", "22, an electronic device 2200 includes a display unit 2202 configured to display a redacted version of first information, optionally a touch-sensitive surface unit 2204, a fingerprint sensor unit 2206, and a processing unit 2208 coupled to the display unit 2202, optionally the touch-sensitive surface unit 2204, and the fingerprint sensor unit 2206.In some embodiments, the processing unit 2208 includes a display enabling unit 2210, a detecting unit 2212, a replacing unit 2214, a maintaining unit 2216, a ceasing unit 2218, and a receiving unit 2220.The processing unit 2208 is configured to, while enabling display (e.g., with the display enabling unit 2210) of the redacted version of the first information on the display unit 2202, detect (e.g., with the detecting unit 2212) a finger input on the fingerprint sensor.", "The processing unit 2208 is configured to, in response to detecting the finger input on the fingerprint sensor: in accordance with a determination that the finger input includes a fingerprint that matches a previously enrolled fingerprint that is authorized to reveal the first information, replace display (e.g., with replacing unit 2214) of the redacted version of the first information with an unredacted version of the first information; and in accordance with a determination that the finger input does not include a fingerprint that matches a previously enrolled fingerprint that is authorized to reveal the first information, maintain display (e.g., with maintaining unit 2216) of the redacted version of the first information on the display unit 2202.In some embodiments, the first redacted information includes a plurality of distinct information items and each information item in the plurality of information items includes a redacted portion and an unredacted portion.", "In some embodiments, replacing display of the redacted version of the first information with the unredacted version of the first information includes replacing display of the redacted portions of the plurality of information items with corresponding unredacted content while maintaining display of the unredacted portions of the plurality of information items.", "In some embodiments, the first information includes a notification that includes identifying information and content, the identifying information is not redacted, and the content is redacted.", "In some embodiments, the first information includes one or more notifications of communications received by the device.", "In some embodiments, the first information includes one or more notifications of social networking updates.", "In some embodiments, the redacted version of the first information includes a copy of the first information that has been rendered unreadable.", "In some embodiments, the redacted version of the first information includes a predefined redaction object that is displayed in place of text in the first information.", "In some embodiments, the redacted version of the first information is displayed on a locked-device user interface of the device.", "In some embodiments, the first information includes a plurality of distinct information items that are redacted.", "In some embodiments, the processing unit 2208 is configured to, while enabling display of the redacted version of the first information, enable display (e.g., with the display enabling unit 2210) of an unredacted version of second information.", "In some embodiments, the processing unit 2208 is configured to: after enabling display of the unredacted version of the first information, continue to detect (e.g., with the detecting unit 2212) the fingerprint on the fingerprint sensor; while continuing to detect the fingerprint on the fingerprint sensor, maintain display (e.g., with the maintaining unit 2216) of the unredacted version of the first information on the display unit 2202; while maintaining display of the unredacted version of the first information, cease to detect (e.g., with the detecting unit 2212) the fingerprint on the fingerprint sensor; and in response to ceasing to detect the fingerprint on the fingerprint sensor, enable redisplay (e.g., with the display enabling unit 2210) of the redacted version of the first information.", "In some embodiments, the processing unit 2208 is configured to: prior to detecting the first input, enable display (e.g., with the display enabling unit 2210) of a locked-device user interface on the display unit 2202; after displaying the unredacted version of the first information, continue to detect (e.g., with the detecting unit 2212) the fingerprint on the fingerprint sensor; while continuing to detect the fingerprint on the fingerprint sensor, maintain display (e.g., with the maintaining unit 2216) of the unredacted version of the first information on the display unit 2202; while maintaining display of the unredacted version of the first information, cease to detect (e.g., with the detecting unit 2212) the fingerprint on the fingerprint sensor; and in response to ceasing to detect the fingerprint on the fingerprint sensor: cease to display (e.g., with the ceasing unit 2218) the first information; and enable display (e.g., with the display enabling unit 2210) of an unlocked-device user interface on the display unit 2202.In some embodiments, the processing unit 2208 is configured to: prior to displaying the redacted version of the first information, receive (e.g., with the receiving unit 2220) a request to display the first information; and in response to receiving the request to display the first information, enable display (e.g., with the display enabling unit 2210) of the redacted version of the first information on the display unit 2202.In some embodiments, the processing unit 2208 is configured to: prior to displaying the redacted version of the first information, detect (e.g., with the detecting unit 2212) the occurrence of a predefined event; and in response to detecting the occurrence of the predefined event, enable display (e.g., with the display enabling unit 2210) of the redacted version of the first information on the display unit 2202.The operations in the information processing methods described above are, optionally implemented by running one or more functional modules in information processing apparatus such as general purpose processors (e.g., as described above with respect to FIGS.", "1A and 3) or application specific chips.", "The operations described above with reference to FIGS.", "21A-21C are, optionally, implemented by components depicted in FIGS.", "1A-1B or FIG.", "22.For example, display operations 2102 and 2108, receiving operation 2104, detecting operations 2106 and 2130, replacing operation 2134 and maintaining operation 2138 are, optionally, implemented by event sorter 170, event recognizer 180, and event handler 190.Event monitor 171 in event sorter 170 detects a contact on touch-sensitive display 112, and event dispatcher module 174 delivers the event information to application 136-1.A respective event recognizer 180 of application 136-1 compares the event information to respective event definitions 186, and determines whether a first contact at a first location on the touch-sensitive surface corresponds to a predefined event or sub-event, such as selection of an object on a user interface.", "When a respective predefined event or sub-event is detected, event recognizer 180 activates an event handler 190 associated with the detection of the event or sub-event.", "Event handler 190 optionally utilizes or calls data updater 176 or object updater 177 to update the application internal state 192.In some embodiments, event handler 190 accesses a respective GUI updater 178 to update what is displayed by the application.", "Similarly, it would be clear to a person having ordinary skill in the art how other processes can be implemented based on the components depicted in FIGS.", "1A-1B.", "Providing Different Unlock Modes Many electronic devices have a locked mode, where the locked mode has a different set of enabled features than the unlocked mode on the corresponding device.", "Because many users wish to keep the contents of their electronic devices private, a locked mode allows for a level of security against unauthorized access to an electronic device.", "A user may wish to have more than one way to unlock an electronic device while it is in a locked state.", "The device described below improves on existing methods by providing different unlock modes to unlock a device while it is in a locked mode of operation, including one or more unlock modes associated with a fingerprint sensor.", "While the device is in a locked mode of operation in which access to a respective set of features of the electronic device is locked, the device detects, with the fingerprint sensor, a first input that corresponds to a request to initiate unlocking the device.", "In response to detecting the first input with the fingerprint sensor the device determines whether the first input meets one of unlock criteria, first unlock-failure criteria, or second unlock-failure criteria.", "In accordance with a determination that the first input meets the unlock criteria, the device transitions the device from the locked mode to an unlocked mode in which the respective set of features of the electronic device is unlocked.", "In accordance with a determination that the first input meets the first unlock-failure criteria, the device maintains the device in the locked mode and adjusts unlock settings so that the device is enabled to be unlocked via an unlock operation in a first set of one or more unlock operations.", "Finally, in accordance with a determination that the first input meets the second unlock-failure criteria, the device maintains the device in the locked mode and adjusts unlock settings so that the device is enabled to be unlocked via an unlock operation in a second set of one or more unlock operations that is different from the first set of unlock operations.", "In some embodiments, the device is an electronic device with a separate display (e.g., display 450) and a separate touch-sensitive surface (e.g., touch-sensitive surface 451).", "In some embodiments, the device is portable multifunction device 100, the display is touch screen 112, and the touch-sensitive surface includes tactile output generators 167 on the display (FIG.", "1A).", "The device described below with reference to 23A-23FF and 24A-24D includes one or more fingerprint sensors 169.In some embodiments, the one or more fingerprint sensors include one or more integrated fingerprint sensors 359-1 (FIG.", "4B) that are integrated in to the touch-sensitive surface (e.g., separate touch-sensitive surface 451 or touch sensitive display system 112).", "In some embodiments, the one or more fingerprint sensors include separate fingerprint sensors 359-2 (FIG.", "4B) that are separate from the touch-sensitive surface (e.g., separate touch-sensitive surface 451 or touch sensitive display system 112).", "Unless specified otherwise, a fingerprint sensor 169 described below is, optionally, either an integrated fingerprint sensor 359-1 or a separate fingerprint sensor 359-2, depending on the configuration of the hardware and software of the device that includes the fingerprint sensor 169.For convenience of explanation, the embodiments described with reference to FIGS.", "23A-23FF and 24A-24D will be discussed with reference to a device with a touch screen 112 and a separate fingerprint sensor 359-2, however analogous operations are, optionally, performed on a device with an integrated fingerprint sensor 359-1 in response to detecting the inputs described in FIGS.", "23A-23FF on the integrated fingerprint sensor 359-1 while displaying the user interfaces shown in FIGS.", "23A-23FF on the display 450.Additionally, analogous operations are, optionally, performed on a device with a display 450 and a separate touch-sensitive surface 451 instead of a touch screen 112 in response to detecting the contacts described in FIGS.", "23A-23FF on a fingerprint sensor 169 (e.g., an integrated fingerprint sensor 359-1 or a separate fingerprint sensor 359-2) and/or the separate touch-sensitive surface 451 while displaying the user interfaces shown in FIGS.", "23A-23FF on the display 450; in such embodiments, the contacts shown in FIGS.", "23A-23FF optionally represent both a focus selector that corresponds to a location on the display 450, and a contact that corresponds to a location of a contact or gesture performed on the separate touch-sensitive surface (e.g., touch-sensitive surface 451), where the focus selector is, optionally: a respective contact, a representative point corresponding to a contact (e.g., a centroid of a respective contact or a point associated with a respective contact), or a centroid of two or more contacts detected on the touch screen 112 and is, optionally, replaced with a displayed cursor.", "FIGS.", "23A-23FF illustrate a portable multifunction device 100 providing different unlock modes, and responding to various successful and unsuccessful unlock operations.", "While in a locked mode, portable multifunction device 100 provides different operations associated with unlock modes, represented by various user interfaces in FIGS.", "23A-23FF.", "FIGS.", "23A-23C illustrate a portable multifunction device 100 being successfully unlocked.", "FIG.", "23A illustrates an exemplary unlock-initiation user interface 2302 displayed on touch screen 112 of a device (e.g.", "device 100).", "In some embodiments, unlock-initiation user interface 2302 is a user interface of an operating system running on device 100.In some embodiments unlock-initiation user interface 2302 is displayed by device 100 in response to device 100 detecting a user input, such as a click of menu button 204.This exemplary unlock-initiation user interface 2302 displays a first visual cue 2304 for one unlock mode.", "In some embodiments, unlock-initiation user interface 2302 displays more than one visual cue, where each visual cue corresponds to a different unlock mode.", "In some embodiments, device 100 is capable of providing more than one unlock mode, even when only one visual cue for one unlock mode is displayed, as in unlock-initiation user interface 2302.In some embodiments, first visual cue 2304 is textual, graphical or any combination thereof.", "In FIG.", "23A, first visual cue 2304 is displayed to instruct the user to make a sliding gesture on touch screen 112 from left to right, to unlock device 100.FIG.", "23B illustrates a fingerprint 2306-1 being detected by fingerprint sensor 169.In this example, detected fingerprint 2306-1 matches an enrolled fingerprint of device 100.In some embodiments in which device 100 has more than one fingerprint sensor 169, fingerprint 2306-1 is detected by any one of the device's fingerprint sensors.", "FIG.", "23C illustrates an unlocked-mode user interface 2308.In some embodiments, the unlocked-mode user interface 2308 is displayed by device 100 in response to detecting a user input that meets one or more unlock criteria, while the device 100 is in a locked mode.", "In some embodiments, unlocked-mode user interface 2308 is displayed in response to the device 100 detecting a fingerprint 2306-1 that matches an enrolled fingerprint of device 100, as in FIG.", "23B.", "In some embodiments, device 100 does not have security measures enabled to lock the phone, or disables one or more security measures to lock the phone for a predetermined amount of time after a successful attempt to unlock the phone.", "In such embodiments, unlocked-mode user interface 2308 is displayed by the device 100 without a user input fulfilling one or more unlock criteria.", "FIGS.", "23D-23K illustrate device 100 being unsuccessfully unlocked by repeated attempts.", "FIG.", "23D illustrates the same unlock-initiation user interface 2302 and first visual cue 2304, as shown in FIG.", "23B.", "In exemplary FIG.", "23D however, fingerprint 2310-1, detected by fingerprint sensor 169, does not match any enrolled fingerprint of device 100.Throughout this document, the term “any enrolled fingerprint of device 100” means any enrolled fingerprint of device 100 that can be used to unlock device 100.In some implementations, all enrolled fingerprints of device 100 can be used to unlock device 100.However, in some other implementations, or in some circumstances, one of more of the enrolled fingerprints of device 100 are configured so that they cannot be used to unlock device 100.For ease of discussion, such enrolled fingerprints are said to be “fingerprints not authorized to unlock device 100,” while the enrolled fingerprints that can be used to unlock device are said to be “fingerprints authorized to unlock device 100.” FIG.", "23E illustrates an exemplary response by device 100 to detection of fingerprint 2310-1, which does not match any enrolled fingerprint of device 100.In FIG.", "23E, first visual cue 2304 is displayed as shaking from side to side for a predetermined amount of time, for a predetermined number of times and/or at a predetermined speed.", "In some embodiments, device 100 uses another technique to alert the user that the detected fingerprint is not recognized to be an enrolled fingerprint, such as playing an audio message, displaying a different visual cue, or any combination of audio and visual feedback.", "FIG.", "23F illustrates an exemplary response by device 100 to detection of one or more fingerprints 2310-1 that do not match any enrolled fingerprint of device 100.FIG.", "23F illustrates the device displaying a second visual cue 2312 on unlock-initiation user interface 2302, instructing the user, in this example, to try to unlock the device by a fingerprint detection again, and an arrow pointing to the right to indicate that the user can alternatively make a sliding gesture on touch screen 112 from left to right, to unlock device 100.In some embodiments, second visual cue 2312 is the same as first visual cue 2304.In some embodiments, device 100 maintains a counter of failed attempts to unlock the device by a particular type of unlock-operation or by any type of unlock operation.", "In some embodiments, second visual cue 2312 indicates how many times the device 100 has detected failed attempts by passcode entry, failed attempts by fingerprint sensing, or failed attempts by any type of unlock-operation.", "In some embodiments, second visual cue 2312 indicates how many attempts to unlock the device by a particular means or by any means are permissible before the device precludes any more attempts for an undefined or predefined length of time.", "In some embodiments, second visual cue 2312 indicates information associated with the last failed attempt to unlock device 100, such as a time stamp.", "FIGS.", "23G-23H illustrate an exemplary response by device 100 to detection of a fingerprint 2310-2 that does not match any enrolled fingerprint of device 100, after displaying second visual cue 2312.In FIG.", "23G, second visual cue 2312 is displayed as shaking (or, equivalently, as being shaken) from side to side for a predetermined amount of time, for a predetermined number of times and/or at a predetermined speed.", "In some embodiments, device 100 uses another technique to alert the user that the detected fingerprint is not recognized as an enrolled fingerprint, such as playing an audio message, displaying a different visual cue, or any combination of audio and visual feedback.", "In some embodiments, device 100 displays another visual cue distinct from the first visual cue 2304 and second visual cue 2312, in response to detecting two or more failed attempts to unlock device 100 by fingerprint detection.", "In some embodiments, after displaying second visual cue 2312 as shaking, the device displays unlock-initiation user interface 2302 with second visual cue 2312 as stationary, as shown in FIG.", "23H.", "FIG.", "23I illustrates a third attempt to unlock device 100, when fingerprint 2310-3 is detected by device, in the sequence of unlock attempts shown in FIGS.", "23D to 23J.", "In this example, fingerprint 2310-3 does not match any enrolled fingerprint of device 100.FIGS.", "23J-23K illustrate an exemplary response by device 100 to detection of a first predefined number of unsuccessful attempts to unlock device 100.In some embodiments, the first predefined number of unsuccessful attempts (e.g., three attempts) corresponds solely to unsuccessful attempts to unlock the device with unrecognized fingerprints.", "For example, FIGS.", "23J-23K illustrate the response of device 100 to detection of a third attempt to unlock device 100 with an unrecognized fingerprint 2310-3, shown in FIG.", "23I.", "FIG.", "23J shows a transitional display on touch screen 112, where device 100 is switching from displaying unlock-initiation user interface 2302 to displaying passcode entry user interface 2314, shown in FIG.", "23K.", "In some embodiments, device 100 transitions from unlock-initiation user interface 2302 to passcode entry user interface 2314 through a lateral sliding motion, as shown in FIGS.", "23J and 23K.", "In some embodiments, while device 100 transitions from unlock-initiation user interface 2302 to passcode entry user interface 2314, other user interface objects that were displayed on unlock-initiation user interface 2302 such as overlay icons 2315 and second visual cue 2312 or first visual cue 2304 are also gradually removed from display on touch screen 112.FIG.", "23K illustrates an exemplary passcode entry user interface 2314 that device 100 transitions to in response to detecting a first predefined number of unsuccessful attempts to unlock device 100.In some embodiments, passcode entry user interface 2314 comprises a third visual cue 2316 and a progress indicator 2318.In FIG.", "23K, exemplary third visual cue 2316 comprises the same text as exemplary second visual cue 2312, however, in some embodiments, third visual cue 2316 comprises text distinct from text in any other visual cues.", "In some embodiments, third visual cue 2316 is textual, graphical or any combination thereof.", "FIGS.", "23L-23P illustrate an exemplary response of device 100 to user entry of a correct sequence of numbers (e.g., a passcode) to unlock the device, after device 100 has detected a first predefined number of unsuccessful attempts (e.g., by repeated detection of fingerprints that do not match any enrolled fingerprint of device 100) to unlock the device.", "In FIG.", "23L, device 100 detects a finger input 2320-1 on touch screen 112 corresponding to entry of the number “1” on the keypad displayed on passcode entry user interface 2314.Progress indicator 2318 changes to show a first shape of a set of geometric shapes (e.g., circles) change from an “unfilled” to “filled” appearance.", "In FIG.", "23L, progress indicator 2318 has 4 circles to indicate that the one or more passcodes to unlock the device comprise 4 digits.", "In some embodiments, progress indicator 2318 has more than 4 geometric shapes, to correspond to more than 4 digits in a valid passcode to unlock device 100, or less than 4 geometric shapes to correspond to less than 4 digits in a valid passcode to unlock device 100.In FIG.", "23M, device 100 detects another finger input 2320-2, and progress indicator 2318 is correspondingly updated to indicate that two finger inputs have been detected.", "In FIG.", "23N, device 100 detects another finger input 2320-3, and progress indicator 2318 is correspondingly updated to indicate that three finger inputs have been detected.", "In FIG.", "23O, device 100 detects another finger input 2320-4, and progress indicator 2318 is correspondingly updated to indicate that four finger inputs have been detected.", "FIG.", "23P illustrates an unlocked-mode user interface 2308, displayed in response to device 100 detecting a valid passcode entered in FIGS.", "23L-23O.", "FIG.", "23Q illustrates an exemplary response of device 100 to user entry of an incorrect sequence of numbers (e.g., an incorrect passcode) to unlock the device, after device 100 has detected a first predefined number of unsuccessful attempts to unlock the device (e.g., by repeated detection of fingerprints that do not match any enrolled fingerprints authorized to unlock the device).", "FIG.", "23Q is displayed, for example, after FIGS.", "23L-23O, if the passcode entered in FIGS.", "23L-23O is determined to be invalid for unlocking device 100.In FIG.", "23Q, progress indicator 2318 is displayed as being shaken from side to side for a predetermined amount of time, for a predetermined number of times and/or at a predetermined speed.", "In some embodiments, device 100 uses another technique to alert the user that the entered passcode is not recognized to be a passcode authorized to unlock device 100, such as playing an audio message, displaying a different visual cue, or any combination of audio and visual feedback.", "In some embodiments, device 100 displays third visual cue 2316 as being shaken from side to side for a predetermined amount of time, for a predetermined number of times and/or at a predetermined speed.", "In FIG.", "23Q, the geometric shapes of progress indicator 2318 change from being filled, as shown in FIG.", "23O, to being unfilled.", "FIGS.", "23R-23T illustrate further exemplary unsuccessful attempts to unlock device 100 by fingerprint detection, in the sequence of unlock attempts shown from FIG.", "23D to FIG.", "23J.", "In FIG.", "23R, detected fingerprint 2310-4 does not match any enrolled fingerprint of device 100.In FIG.", "23S, progress indicator 2318 is displayed as being shaken from side to side for a predetermined amount of time, for a predetermined number of times and/or at a predetermined speed.", "In some embodiments, device 100 uses another technique to alert the user that the detected fingerprint is not recognized to be an enrolled fingerprint authorized to unlock device 100, such as playing an audio message, displaying a different visual cue, or any combination of audio and visual feedback.", "In some embodiments, progress indicator 2318 remains stationary and third visual cue 2316 is displayed differently to indicate detection of fingerprint that does not match any enrolled fingerprint authorized to unlock device 100.For example, third visual cue 2316 is displayed as being shaken from side to side for a predetermined amount of time, for a predetermined number of times and/or at a predetermined speed.", "FIG.", "23T illustrates an exemplary fourth visual cue 2322 displayed on passcode entry user interface 2314 in response to detecting a second predefined threshold of unsuccessful attempts to unlock device 100.In some embodiments, fourth visual cue 2322 is displayed to indicate that device 100 has disabled the ability to unlock the device through fingerprint detection.", "In some embodiments, the second predefined threshold of unsuccessful attempts to unlock corresponds solely to attempts by fingerprint detection.", "FIG.", "23U illustrates an exemplary unlock-initiation user interface 2302.In some embodiments, unlock-initiation user interface 2302 is displayed in response to detecting a predefined user action, such as pressing menu button 204, while the display of the device is in a low power mode (e.g., the display is off and/or the display backlight is off).", "In some embodiments, unlock-initiation user interface 2302 is also displayed by device 100 after a predefined period of time has elapsed, while the device is in a locked mode and an idleness condition is detected (e.g., no user input for the predefined period of time).", "FIG.", "23V illustrates an exemplary response of device 100 to detection of a fingerprint 2310-5, detected while displaying unlock-initiation user interface 2302 (FIG.", "23U), where fingerprint 2310-5 does not match any enrolled fingerprint of device 100 authorized to unlock device 100.In this example, device 100 has previously detected at least one fingerprint 2310 that also did not match any enrolled fingerprint of device 100 authorized to unlock device 100 prior to detecting fingerprint 2310-5 in unlock-initiation user interface 2302, shown in FIG.", "23U.", "FIG.", "23V illustrates an exemplary response of device 100 to detection of fingerprint 2310-5 (which does not match any enrolled fingerprint of device 100 authorized to unlock device 100) in FIG.", "23U.", "In FIG.", "23V, device 100 displays the passcode entry user interface 2314, along with a fifth visual cue 2324 that alerts the user to its inability to recognize the detected fingerprint.", "In some embodiments, fifth visual cue 2324 alerts the user to at least one prior unsuccessful attempt to unlock device 100 by fingerprint detection, and in some embodiments fifth visual cue 2324 comprises information regarding the one or more prior unsuccessful attempts to unlock device 100.FIGS.", "23W and 23X illustrate device 100 transitioning from display of unlock-initiation user interface 2302 to passcode entry user interface 2314, in response to detecting a device unlock finger gesture 2326 on touch screen 112.In this example, device unlock finger gesture 2326 is a lateral movement from left to right on unlock-initiation user interface 2302, for example from position 2326-1 to position 2326-2.In some embodiments the direction of device unlock finger gesture 2326 is from right to left.", "Exemplary finger gesture 2326 corresponds to the instructions displayed by first visual cue 2304.FIG.", "23X illustrates the transition to passcode entry user interface 2314, shown in FIG.", "23Y.", "FIG.", "23Y illustrates an exemplary passcode entry user interface 2314 displayed by device 100 in response to detecting device unlock finger gesture 2326 in FIG.", "23W.", "FIG.", "23W shows a sixth visual cue 2328 (e.g., “Enter Passcode”), and a progress indicator 2318.In some embodiments, sixth visual cue 2328 indicates to the user that the device may be unlocked by passcode entry.", "In some implementations, sixth visual cue 2328 indicates additional methodologies for unlocking the device, such as fingerprint detection, another technique, or a combination of techniques.", "In FIG.", "23Y, a fingerprint 2306-2 is detected on fingerprint sensor 169.In this example, fingerprint 2306-2 matches an enrolled fingerprint authorized to unlock device 100.FIGS.", "23Z-23DD illustrate an exemplary response by device 100 to detection of a fingerprint 2306-2 on fingerprint sensor 169, while displaying passcode entry user interface 2314.In FIGS.", "23Z-23CC, progress indicator 2318 is progressively modified by filling in geometric shapes in progress indicator 2318, one at a time.", "In some embodiments, progress indicator 2318 is progressively modified while device 100 determines whether the detected fingerprint 2306-2 matches an enrolled fingerprint authorized to unlock device 100.In some embodiments, upon determining that a fingerprint 2306-2 received while displaying passcode entry user interface 2314 matches an enrolled fingerprint authorized to unlock device 100, progress indicator 2318 is instantly modified to display all the geometric shapes as being filled in.", "FIG.", "23DD illustrates an unlocked-mode user interface 2308, displayed after device 100 displays the user interfaces shown in FIGS.", "23Y-23CC and device 100 has made a determination that the detected fingerprint matches an enrolled fingerprint authorized to unlock device 100.FIGS.", "23EE and 23FF illustrate an exemplary response by device 100 to detection of a fingerprint 2310-6, by fingerprint sensor 169, while displaying passcode entry user interface 2314.For example, FIG.", "23EE follows FIGS.", "23W-23X, after device 100 detects finger gesture 2326 on touch screen 112.FIG.", "23FF illustrates an exemplary response by device 100 to detection of a fingerprint 2310-6 (shown in FIG.", "23EE) that does not match any enrolled fingerprint authorized to unlock device 100.In FIG.", "23FF, a visual cue, such as third visual cue 2316 (e.g., “try again”) is displayed, and progress indicator 2318 is displayed as being shaken from side to side for a predetermined amount of time, for a predetermined number of times and/or at a predetermined speed.", "FIGS.", "24A-24D are flow diagrams illustrating a method 2400 of providing different unlock modes in accordance with some embodiments.", "The method 2400 is performed at an electronic device (e.g., device 300, FIG.", "3, or portable multifunction device 100, FIG.", "1A) with a display and fingerprint sensor.", "In some embodiments, the display is a touch screen display and the touch-sensitive surface is on the display.", "In some embodiments, the display is separate from the touch-sensitive surface.", "Some operations in method 2400 are, optionally, combined and/or the order of some operations is, optionally, changed.", "As described below, the method 2400 provides an intuitive way to provide different unlock modes.", "The method reduces the cognitive burden on a user when providing different unlock modes, thereby creating a more efficient human-machine interface.", "For battery-operated electronic devices, enabling a user to unlock an electronic device faster and more efficiently conserves power and increases the time between battery charges.", "While the device is in a locked mode of operation in which access to a respective set of features of the electronic device is locked, the device detects (2406), with the fingerprint sensor, a first input that corresponds to a request to initiate unlocking the device.", "In some embodiments, prior to detecting the first input, the device displays (2402) an unlock-initiation user interface (e.g., a slide-to-unlock user interface, shown in FIG.", "23U) that does not include a passcode entry user interface, wherein while the unlock-initiation user interface is displayed, the device is enabled to be unlocked using a fingerprint but is not enabled to be unlocked using a passcode.", "For example, in a slide-to-unlock user interface, a passcode entry user interface is not displayed and thus there is no way to enter a passcode to unlock the device.", "In some embodiments, prior to detecting the first input, while the display of the device is in a low power mode (e.g., the display is off and/or the display backlight is off), the device enables (2404) the device to be unlocked using a fingerprint without enabling the device to be unlocked using a passcode.", "For example, if the display is off and the display backlight is off, a passcode entry user interface is not displayed and thus there is no way to enter a passcode to unlock the device.", "The device performs several operations in response to detecting (2408) the first input with the fingerprint sensor in method 2400.In response to detecting (2408) the first input with the fingerprint sensor, the device determines (2410) whether the first input meets one of unlock criteria, first unlock-failure criteria, or second unlock-failure criteria.", "In accordance with a determination that the first input meets the unlock criteria, the device transitions (2412) the device from the locked mode to an unlocked mode in which the respective set of features of the electronic device is unlocked.", "In some embodiments, the unlock criteria include (2414) a criterion that is met when the first input includes a fingerprint detected with the fingerprint sensor that matches a fingerprint that is enrolled with the device.", "For example, if the first input corresponds to an enrolled fingerprint authorized to unlock the device, the device transitions from a locked mode to an unlocked mode, as seen in FIGS.", "23B and 23C.", "In some embodiments, in accordance with a determination that the first input does not meet the unlock criteria, the device displays (2416) a passcode entry user interface.", "For example, if the first input is fingerprint 2310-3 in FIG.", "23I, which the device determines does not match any enrolled fingerprint authorized to unlock device 100, the device displays exemplary passcode entry user interface 2314 in FIG.", "23K.", "In some embodiments, in accordance with the determination that the first input meets first unlock-failure criteria, the device displays (2418) a first unlock interface that includes the passcode entry user interface, and a visual indication that the device is enabled to be unlocked using a fingerprint.", "In some embodiments, in accordance with the determination that the first input meets second unlock-failure criteria, the device displays (2420) a second unlock interface that includes the passcode entry user interface, and a visual indication that the device has been disabled from being unlocked using a fingerprint.", "For example, FIG.", "23T illustrates an exemplary second unlock interface that includes the passcode entry user interface 2314, and a visual indication that the device has been disabled from being unlocked using a fingerprint (e.g., fourth visual cue 2322).", "In some circumstances, while the device displays (2422) the passcode entry user interface, the device receives a passcode entered via the passcode entry user interface.", "For example, FIGS.", "23K-FIG.", "23O illustrate device 100 receiving a passcode entered via passcode entry user interface 2314.In response to receiving the passcode, and in accordance with a determination that the passcode matches a current passcode for the device, the device transitions the device from the locked mode of operation to the unlocked mode of operation (e.g., FIG.", "23P).", "In accordance with a determination that the passcode does not match the current passcode for the device, the device maintains the device in the locked mode (e.g., FIG.", "23Q).", "In some embodiments, in response to receiving the passcode, the device determines (2424) whether passcode-timeout criteria have been met, the passcode-timeout criteria including a criterion that is met when at least a first number of unsuccessful passcode unlock attempts have been made (e.g., between one and four unsuccessful passcode unlock attempts).", "Alternatively, the passcode-timeout criteria includes a criterion that is met when at least a first number of unsuccessful passcode unlock attempts have been made within a predefined time period.", "In accordance with a determination that the passcode-timeout criteria have been met, the device disables the device from being unlocked using a passcode for a timeout period of time.", "For example, the device ceases to display the passcode entry user interface, ceases to accept input for the passcode entry user interface and/or disables unlocking via the passcode entry user interface even if the current passcode is entered in the passcode entry user interface.", "In some embodiments, in response to receiving the passcode, the device determines (2426) whether data-preclusion criteria have been met, the data-preclusion criteria including a criterion that is met when at least a second number of unsuccessful passcode unlock attempts have been made (e.g., between 5 and 20 unsuccessful passcode unlock attempts).", "Alternatively, the data-preclusion criteria includes a criterion that is met when at least the second number of unsuccessful passcode unlock attempts have been made within a predefined time period.", "In accordance with a determination that the data-preclusion criteria have been met, the device renders private data stored on the device unusable.", "For example, the device deletes, encrypts or otherwise removes the ability to access private data such user communications, contact information, financial information, account information and optionally other data on the device.", "In some embodiments, when the data-preclusion criteria have been met, the device performs a device-disable operation that renders the device unusable.", "In some embodiments, the passcode entry user interface includes (2428) a progress indicator that provides a visual indication of progress toward entering a passcode when characters are entered via the passcode entry user interface.", "For example, the progress indicator is a sequence of circles or other geometric shapes (e.g., as in FIGS.", "23K to 23O) that each correspond to a character in the passcode, which are filled in or highlighted as characters are entered in the passcode entry user interface.", "In some embodiments, while the passcode entry user interface is displayed on the display, the device detects (2430) a fingerprint on the fingerprint sensor, and in response to detecting the fingerprint on the fingerprint sensor, displays an animation in the progress indicator that indicates progress towards unlocking the device.", "For example, an animation that indicates that progress is being made toward unlocking the device (e.g., in FIGS.", "23Y to 23CC) is provided in response to detecting the fingerprint, even though the user at the moment is not entering individual characters in the passcode with a keyboard.", "In some embodiments, the device receives (2432) an unlock request to unlock the device that includes authentication information.", "For example, the device receives a passcode entered via the passcode entry user interface or a fingerprint detected on a fingerprint sensor.", "While receiving the authentication information, the device displays an animation of the progress indicator changing from a first state (e.g., the progress indicator comprising a sequence of empty circles or other geometric objects as in FIG.", "23Y) to a second state (e.g., the progress indicator comprising a sequence of full circles or other geometric objects as in FIG.", "23CC).", "In response to receiving the unlock request, the device determines whether the authentication information is sufficient to unlock the device.", "In accordance with a determination that the authentication information is sufficient to unlock the device (e.g., a passcode that matches a previously established passcode or a fingerprint that matches a previously enrolled fingerprint that is authorized to unlock the device), the device transitions the device from the locked mode of operation to the unlocked mode of operation, and in accordance with a determination that the authentication information is not sufficient to unlock the device (e.g., a passcode that does not match a previously established passcode or a fingerprint that does not match a previously enrolled fingerprint authorized to unlock the device), the device maintains the device in the locked mode of operation and displays an authentication rejection animation (e.g., shaking the progress indicator from side to side) in which the progress indicator changes (e.g., reverts or is reset) from the second state to the first state.", "In some embodiments, the same authentication rejection animation is displayed regardless of whether the authentication information is a passcode or a fingerprint.", "The method 2400 further includes: in accordance with a determination that the first input meets the first unlock-failure criteria, the device maintains (2434) the device in the locked mode and adjusts unlock settings of the device so that the device is enabled to be unlocked via an unlock operation in a first set of one or more unlock operations.", "For example, the device enables passcode entry by displaying a passcode interface in addition to still permitting use of the fingerprint sensor to unlock in the first set of unlock operations.", "In some embodiments, the first set of unlock operations includes (2436) an unlock operation that uses a fingerprint to unlock the device and another unlock operation that uses a passcode to unlock the device.", "In some embodiments, the device is enabled to be unlocked using a fingerprint when the device is configured to transition from the locked mode of operation to the unlocked mode of operation in response to detecting a fingerprint on the fingerprint sensor that matches a previously enrolled fingerprint (e.g., an enrolled fingerprint authorized to unlock the device).", "In some embodiments, the device is enabled to be unlocked using a passcode when the device is configured to transition from the locked mode of operation to the unlocked mode of operation in response to detecting entry of a passcode that matches a previously established passcode.", "In accordance with a determination that the first input meets the second unlock-failure criteria, the device maintains (2438) the device in the locked mode and adjusts unlock settings so that the device is enabled to be unlocked via an unlock operation in a second set of one or more unlock operations that is different from the first set of unlock operations.", "For example, the device enables the passcode entry but fingerprint authentication is disabled in the second set of unlock operations.", "In some embodiments, the second set of unlock operations includes (2440) an unlock operation that uses a passcode to unlock the device and excludes an unlock operation that uses a fingerprint to unlock the device.", "For example, FIG.", "23T shows a user interface corresponding to a second set of unlock operations that includes an unlock operation that uses a passcode to unlock the device and excludes an unlock operation that uses a fingerprint to unlock the device.", "In some embodiments, the first input includes a fingerprint input on the fingerprint sensor.", "The first unlock-failure criteria includes (2442) a criterion that is met when the device has detected at least a first threshold number of unsuccessful attempts to unlock the device with one or more unrecognized fingerprints (e.g., detected fingerprints that are not found to match any of the enrolled fingerprints), and the second unlock-failure criteria includes a criterion that is met when the device has detected at least a second threshold number of unsuccessful attempts to unlock the device with one or more unrecognized fingerprints, where the second threshold number is greater than the first threshold number.", "For example, the second unlock-failure criteria are met when the device has detected five unsuccessful fingerprint authorization attempts.", "In some embodiments, the device maintains a counter of the number of unsuccessful attempts to unlock the device, where such record is only reset after successfully unlocking the device.", "In some embodiments, the device maintains a counter of the number of unsuccessful attempts to unlock the device by fingerprint detection, where such record is only reset after successfully unlocking the device.", "In some embodiments, the first unlock-failure criteria includes (2444) a criterion that is met when the device has detected less than the second number of unsuccessful attempts to unlock the device with one or more unrecognized fingerprints.", "For example, the first unlock-failure criteria are met when the device has detected one to four unsuccessful fingerprint authorization attempts.", "It should be understood that the particular order in which the operations in FIGS.", "24A-24D have been described is merely exemplary and is not intended to indicate that the described order is the only order in which the operations could be performed.", "One of ordinary skill in the art would recognize various ways to reorder the operations described herein.", "Additionally, it should be noted that details of other processes described herein with respect to other methods described herein (e.g., those listed in the “Description of Embodiments” section above) are also applicable in an analogous manner to method 2400 described above with respect to FIGS.", "24A-24D.", "For example, the fingerprints, contacts, gestures and user interface objects described above with reference to method 2400 optionally have one or more of the characteristics of the fingerprints, contacts, gestures and user interface objects described herein with reference to other methods described herein (e.g., those listed in the “Description of Embodiments” section above).", "For brevity, these details are not repeated here.", "In accordance with some embodiments, FIG.", "25 shows a functional block diagram of an electronic device 2500 configured in accordance with the principles of the various described embodiments.", "The functional blocks of the device are, optionally, implemented by hardware, software, or a combination of hardware and software to carry out the principles of the various described embodiments.", "It is understood by persons of skill in the art that the functional blocks described in FIG.", "25 are, optionally, combined or separated into sub-blocks to implement the principles of the various described embodiments.", "Therefore, the description herein optionally supports any possible combination or separation or further definition of the functional blocks described herein.", "As shown in FIG.", "25, an electronic device 2500 includes a display unit 2502 configured to display a graphical user interface, a fingerprint sensor unit 2506; and a processing unit 2508 coupled to the display unit 2502 and the fingerprint sensor unit 2506.In some embodiments, the electronic device 2500 includes a touch-sensitive surface unit 2504 configured to receive contacts, coupled to the processing unit 2508, the fingerprint sensor unit 2506 and the display unit 2502.In some embodiments, the processing unit 2508 includes a determining unit 2510, a transitioning unit 2512, a maintaining unit 2514, an adjusting unit 2516, an enabling unit 2518, a receiving unit 2520, a disabling unit 2522, a rendering unit 2524 and a detecting unit 2526.While the device is in a locked mode of operation in which access to a respective set of features of the electronic device is locked, the fingerprint sensor unit 2508, detects a first input that corresponds to a request to initiate unlocking the device.", "In response to detecting the first input with fingerprint sensor unit 2506, processing unit 2508 is configured to: determine whether the first input meets one of unlock criteria, first unlock-failure criteria, or second unlock-failure criteria (e.g., with determining unit 2510).", "Processing unit 2508 is further configured to: in accordance with a determination that the first input meets the unlock criteria, transition the device from the locked mode to an unlocked mode in which the respective set of features of the electronic device is unlocked (e.g., with transitioning unit 2512).", "Processing unit 2508 is further configured to: in accordance with a determination that the first input meets the first unlock-failure criteria, maintain (e.g., with maintaining unit 2514) the device in the locked mode and adjust (e.g., with adjusting unit 2516) unlock settings so that the device is enabled to be unlocked via an unlock operation in a first set of one or more unlock operations.", "Processing unit 2508 is further configured to: in accordance with a determination that the first input meets the second unlock-failure criteria, maintain (e.g., with maintaining unit 2514) the device in the locked mode and adjust (e.g., with adjusting unit 2516) unlock settings so that the device is enabled to be unlocked via an unlock operation in a second set of one or more unlock operations that is different from the first set of unlock operations.", "In some embodiments, the first input includes a fingerprint input on fingerprint sensor unit 2506, the first unlock-failure criteria includes a criterion that is met when the device has detected at least a first threshold number of unsuccessful attempts to unlock the device with one or more unrecognized fingerprints, and the second unlock-failure criteria includes a criterion that is met when the device has detected at least a second threshold number of unsuccessful attempts to unlock the device with one or more unrecognized fingerprints, where the second threshold number is greater than the first threshold number.", "In some embodiments, prior to detecting the first input, the device displays with display unit 2502, an unlock-initiation user interface that does not include a passcode entry user interface.", "Furthermore, while the unlock-initiation user interface is displayed, the device is enabled to be unlocked using a fingerprint but is not enabled to be unlocked using a passcode.", "In some embodiments, the processing unit 2508 is further configured to enable (e.g., with enabling unit 2518) the device to be unlocked using a fingerprint, prior to detecting the first input, while the display of the device is in a low power mode, without enabling the device to be unlocked using a passcode.", "In some embodiments, in response to detecting the first input and in accordance with a determination that the first input does not meet the unlock criteria, the device displays with display unit 2502 a passcode entry user interface.", "In some embodiments, in accordance with the determination that the first input meets the first unlock-failure criteria, the device displays with display unit 2502 a first unlock interface that includes the passcode entry user interface, and a visual indication that the device is enabled to be unlocked using a fingerprint.", "In some embodiments, in accordance with the determination that the first input meets the second unlock-failure criteria, the device displays with display unit 2502 a second unlock interface that includes the passcode entry user interface, and a visual indication that the device has been disabled from being unlocked using a fingerprint.", "In some embodiments, prior to detecting the first input, the device displays with display unit 2502 an unlock-initiation user interface that does not include a passcode entry user interface.", "Furthermore, while the unlock-initiation user interface is displayed, the device is enabled to be unlocked using a fingerprint but is not enabled to be unlocked using a passcode.", "In some embodiments, the processing unit 2508 is further configured to enable (e.g., with enabling unit 2518) the device to be unlocked using a fingerprint, prior to detecting the first input, while the display of the device is in a low power mode, without enabling the device to be unlocked using a passcode.", "In some embodiments, in response to detecting the first input and in accordance with a determination that the first input does not meet the unlock criteria, the device displays with display unit 2502 a passcode entry user interface.", "In some embodiments, in accordance with the determination that the first input meets the first unlock-failure criteria, the device displays with display unit 2502 a first unlock interface that includes the passcode entry user interface and a visual indication that the device is enabled to be unlocked using a fingerprint.", "In some embodiments, while the device displays with display unit 2502 the passcode entry user interface, the processing unit 2508 is further configured to: receive (e.g., with receiving unit 2520) a passcode entered via the passcode entry user interface; transition (e.g., with transitioning unit 2512) the device from the locked mode of operation to the unlocked mode of operation, in response to receiving the passcode and in accordance with a determination that the passcode matches a current passcode for the device; and maintain (e.g., with maintaining unit 2514) the device in the locked mode, in response to receiving the passcode and in accordance with a determination that the passcode does not match the current passcode for the device.", "In some embodiments, the processing unit 2508 is further configured to: determine (e.g., with determining unit 2510), in response to receiving the passcode, whether passcode-timeout criteria have been met, the passcode-timeout criteria including a criterion that is met when at least a first number of unsuccessful passcode unlock attempts have been made, and disable (e.g., with disabling unit 2522) the device from being unlocked using a passcode for a timeout period of time, in accordance with a determination that the passcode-timeout criteria have been met.", "In some embodiments, the processing unit 2508 is further configured to: determine (e.g., with determining unit 2510), in response to receiving the passcode, whether data-preclusion criteria have been met, the data-preclusion criteria including a criterion that is met when at least a second number of unsuccessful passcode unlock attempts have been made, and render (e.g., with rendering unit 2524), in response to receiving the passcode, private data stored on the device unusable, in accordance with a determination that the data-preclusion criteria have been met.", "In some embodiments, while the passcode entry user interface is displayed on the display, the device detects, with the fingerprint sensor unit 2506, a fingerprint on fingerprint sensor unit 2506, and in response to detecting the fingerprint on fingerprint sensor unit 2506, displays with display unit 2502, an animation in the progress indicator that indicates progress towards unlocking the device (e.g., progress toward filling in the passcode).", "In some embodiments, processing unit 2508 is further configured to: receive (e.g.", "with receiving unit 2520), an unlock request to unlock the device that includes authentication information.", "In such embodiments, display unit 2502 displays an animation of the progress indicator changing from a first state to a second state, while receiving the authentication information.", "Processing unit 2508 is further configured to determine (e.g., with determining unit 2510), in response to receiving the unlock request, whether the authentication information is sufficient to unlock the device, transition (e.g.", "with transitioning unit 2512) the device from the locked mode of operation to the unlocked mode of operation, in accordance with a determination that the authentication information is sufficient to unlock the device; and maintain (e.g., with maintaining unit 2514), the device in the locked mode of operation, in accordance with a determination that the authentication information is not sufficient to unlock the device, while display unit 2502 displays an authentication rejection animation in which the progress indicator changes from the second state to the first state.", "The operations in the information processing methods described above are, optionally implemented by one or more functional modules in information processing apparatus such as general purpose processors (e.g., as described above with respect to FIGS.", "1A and 3) or application specific chips.", "The operations described above with reference to FIGS.", "24A-24D are, optionally, implemented by components depicted in FIGS.", "1A-1B or FIG.", "25.For example, detection operation 2406, determination operation 2410, and enablement operation 2404 are, optionally, implemented by event sorter 170, event recognizer 180, and event handler 190.Event monitor 171 in event sorter 170 detects a contact on touch-sensitive display 112, and event dispatcher module 174 delivers the event information to application 136-1.A respective event recognizer 180 of application 136-1 compares the event information to respective event definitions 186, and determines whether a first contact at a first location on the touch-sensitive surface corresponds to a predefined event or sub-event, such as selection of an object on a user interface.", "When a respective predefined event or sub-event is detected, event recognizer 180 activates an event handler 190 associated with the detection of the event or sub-event.", "Event handler 190 optionally utilizes or calls data updater 176 or object updater 177 to update the application internal state 192.In some embodiments, event handler 190 accesses a respective GUI updater 178 to update what is displayed by the application.", "Similarly, it would be clear to a person having ordinary skill in the art how other processes can be implemented based on the components depicted in FIGS.", "1A-1B.", "Controlling Access to Device Information and Features and Unlocking the Device Many electronic devices have graphical user interfaces that are displayed while the device is locked.", "For example, notifications and settings user interfaces can be displayed while the device is locked.", "However, displaying notifications or settings while the device is locked can compromise the device and/or user data, as an unauthorized user who has the device in his possession can read notifications or change device settings despite being an unauthorized user.", "However, suppressing display of all notifications and control of settings while the device is locked inconveniences authorized users of the device.", "The methods below describe an improved way to control access to device information and features and to unlock the device.", "While a device with a fingerprint sensor is locked, a user interface—such as one for viewing notifications, changing settings, or viewing photos—is brought up in a limited-access mode.", "In a limited-access mode, the notification, settings, or photo viewing user interface provides less than full access to device information and features.", "For example, notifications are partially or fully redacted, device settings that can be changed are restricted, or previously stored digital photographs are not viewable.", "While viewing the user interface in a limited access mode, the user attempts to authenticate himself or herself with a fingerprint on the device's fingerprint sensor.", "If authentication is successful, the user interface changes to a full-access mode and the device is unlocked.", "The device remains unlocked when the full-access user interface is dismissed.", "If authentication is not successful, the user interface remains in its limited-access mode and the device remains locked.", "The device remains locked when the limited-access user interface is dismissed.", "This method increases security by controlling access to device information and controls prior to fingerprint authentication, yet seamlessly provides immediate access to more device information and features and unlocks the device upon successful fingerprint authentication.", "In some embodiments, the device is an electronic device with a separate display (e.g., display 450) and a separate touch-sensitive surface (e.g., touch-sensitive surface 451).", "In some embodiments, the device is portable multifunction device 100, the display is touch screen 112, and the touch-sensitive surface includes tactile output generators 167 on the display (FIG.", "1A).", "The device described below with reference to 26A-26X and 27A-27D includes one or more fingerprint sensors 169.In some embodiments, the one or more fingerprint sensors include one or more integrated fingerprint sensors 359-1 (FIG.", "4B) that are integrated in to the touch-sensitive surface (e.g., separate touch-sensitive surface 451 or touch sensitive display system 112).", "In some embodiments, the one or more fingerprint sensors include separate fingerprint sensors 359-2 (FIG.", "4B) that are separate from the touch-sensitive surface (e.g., separate touch-sensitive surface 451 or touch sensitive display system 112).", "Unless specified otherwise, a fingerprint sensor 169 described below is, optionally, either an integrated fingerprint sensor 359-1 or a separate fingerprint sensor 359-2, depending on the configuration of the hardware and software of the device that includes the fingerprint sensor 169.For convenience of explanation, the embodiments described with reference to FIGS.", "26A-26X and 27A-27D will be discussed with reference to a device with a touch screen 112 and a separate fingerprint sensor 359-2, however analogous operations are, optionally, performed on a device with an integrated fingerprint sensor 359-1 in response to detecting the inputs described in FIGS.", "26A-26X on the integrated fingerprint sensor 359-1 while displaying the user interfaces shown in FIGS.", "26A-26X on the display 450.Additionally, analogous operations are, optionally, performed on a device with a display 450 and a separate touch-sensitive surface 451 instead of a touch screen 112 in response to detecting the contacts described in FIGS.", "26A-26X on a fingerprint sensor 169 (e.g., an integrated fingerprint sensor 359-1 or a separate fingerprint sensor 359-2) and/or the separate touch-sensitive surface 451 while displaying the user interfaces shown in FIGS.", "26A-26X on the display 450; in such embodiments, the contacts shown in FIGS.", "26A-26X optionally represent both a focus selector that corresponds to a location on the display 450, and a contact that corresponds to a location of a contact or gesture performed on the separate touch-sensitive surface (e.g., touch-sensitive surface 451), where the focus selector is, optionally: a respective contact, a representative point corresponding to a contact (e.g., a centroid of a respective contact or a point associated with a respective contact), or a centroid of two or more contacts detected on the touch screen 112 and is, optionally, replaced with a displayed cursor.", "FIG.", "26A illustrates locked device interface 2600 displayed on a display of a device (e.g., on touch screen 112 of device 100).", "Locked device interface 2600 is a user interface that indicates to users of device 100 that device 100 is in locked mode (i.e., device 100 is locked), and thus access to one or more features of device 100 is locked.", "For example, while device 100 is locked, user interface 400 is inaccessible (and thus the user is unable to launch at least some applications on device 100).", "In some embodiments, locked device interface 2600 provides limited information to users.", "For example, locked device interface 2600 includes current date and time 2602 and instructions or hints 2604 on how to unlock device 100.Locked device interface 2600 also includes one or more user interface objects for displaying respective user interfaces or launching specific applications.", "For example, locked device interface 2600 includes handles 2606 and 2608, and icon 2610.Handle 2606 is adjacent to the top edge of touch screen 112, and 2608 is adjacent to the bottom edge of touch screen 112.A user performs a gesture (e.g., a swipe gesture) starting from handle 2606 to activate display of a notification interface (e.g., notification interface 2616, FIG.", "26C).", "A user performs a gesture (e.g., a swipe gesture) starting from handle 2608 to activate display of settings-management interface (e.g., settings-management interface 2650, FIG.", "26N).", "A user performs a gesture (e.g., a swipe gesture) on icon 2610 to activate display of a camera interface (e.g., camera interface 2678, FIG.", "26U).", "FIG.", "26A illustrates a gesture detected on touch screen 112 while device 100 is in a locked mode.", "The gesture (e.g., a swipe gesture) includes contact 2612 detected on handle 2606, and contact 2612, while detected on handle 2606, moving in direction 2614.In response to detecting the gesture, device 100 displays notification interface 2616 on touch screen 112, as shown in FIG.", "26C, and device 100 remains in locked mode.", "In some embodiments, the transition from displaying locked device interface 2600 to displaying notification interface 2616 includes an animation in which notification interface 2616 slides onto touch screen 112 in accordance with the movement of contact 2612, as shown in FIGS.", "26A-26C; contact 2612 swipes notification interface 2616 onto touch screen 112.In the animation, notification interface 2616 slides over locked screen interface 2600.In some embodiments, notification interface 2616 is translucent and locked device interface 2600 is partially visible (e.g., visible but blurred or faint) under notification interface 2616, as shown in FIG.", "26C.", "For example, current date and time 2602 and unlock instructions 2604 are visible but faint under notification interface 2616.In some other embodiments, notification interface 2616 is opaque and locked device interface 2600 is not visible under notification interface 2616.Notification interface 2616 is a user interface for displaying notifications 2620 associated with respective applications on device 100.In some embodiments, notification interface 2616 includes one or more sections 2618.Each respective section 2618 is associated with a respective application on device 100, and displays one or more notifications 2620 associated with that respective application.", "A respective notification 2620 includes one or more portions for displaying respective fields of information.", "For example, a notification for a message or email includes respective portions for a sender, a date/time, and an indicator of content (e.g., the subject, and/or a snippet of the message/email body).", "As another example, a notification for a calendar event invite includes respective portions for a name and/or description of the event, a source of the invite (e.g., a contact that sent the invite), and a date/time of the event.", "What portions and information a notification 2620 includes is typically determined by the respective associated application.", "In some embodiments, notification interface 2616 also includes two or more view filters 2638.A respective view filter 2638 corresponds to a respective set of criteria for filtering notifications 2620 displayed in notification interface 2616; notifications 2620 that satisfy the criteria are displayed and the notifications 2620 that don't satisfy the criteria are hidden.", "For example, in FIG.", "5C, view filter “All” 2638-1 is active; all outstanding notifications 2620 (other than notifications that are hidden in accordance with restrictions on access to notification interface 2616, as described below) are displayed.", "A non-active view filter 2638 is activated by a gesture performed on that view filter (e.g., a tap gesture).", "For example, in response to detecting a tap gesture performed on view filter “Missed” 2638-2, device 100 displays notifications 2620 that have not been addressed within a predetermined time period (e.g., the prior 24 hours) in notification interface 2616, and omits display of notifications 2620 that do not satisfy this not-addressed-within-time-period criterion.", "Because device 100 is locked when the gesture with contact 2612 is detected, notification interface 2616 is displayed in a limited-access mode.", "While notification interface 2616 is in the limited-access mode, access to notification interface 2616 is restricted.", "In some embodiments, restrictions on access to notification interface 2616 include one or more of the following: redaction of information in one or more of notifications 2620, omission from display (e.g., hiding from display) of one or more sections 2618 that otherwise have outstanding notifications, and omission from display of one or more view filters 2638.For example, FIG.", "26C shows redacted notifications 2620 in notification interface 2616.As an alternative example.", "FIG.", "26D shows redacted notifications 2620 and omission of section 2618-2 in notification interface 2616.Also, FIGS.", "26C and 26D both show that view filter “Today” 2638-3 (FIG.", "26H) is hidden.", "In some embodiments, redaction of a notification 2620 includes replacement of all or some portions of the notification with generic, placeholder text.", "For example, in FIG.", "5C, notification 2620-1 is a notification for a message received by a messaging application on device 100.Notification 2620-1 includes portion 2622 for identifying the sender of the message, portion 2624 for a timestamp of the message (e.g., date/time the message was sent or received), and portion 2626 for all or some (e.g., a snippet) of the contents of the message.", "When notification 2620-1 is not redacted, the portions 2622, 2624, and 2626 are filled with their actual respective contents (i.e., actual sender name, actual timestamp, and actual message contents, respectively).", "When notification 2620-1 is redacted, one or more of portions 2622, 2624, and 2626 are replaced with respective generic text.", "As shown in FIG.", "26C, notification 2620-1 is partially redacted.", "Portion 2622 shows the actual sender name, but portion 2624 shows generic text “Time” instead of the actual timestamp, and portion 2626 shows generic text “Message” instead of a snippet of the actual message.", "As another example, notification 2620-2 in FIG.", "26C is a notification for a calendar event invite received by a calendar application on device 100.Notification 2620-2 includes portion 2628 for the name or description of the event, portion 2630 for a source of the invite (e.g., the inviter), and portion 2632 for the time of the event.", "In FIG.", "26C, actual contents in portions 2628, 2630, and 2632 are replaced with generic text “Event,” “Invitation from Contact,” and “Time,” respectively.", "In some other embodiments, redaction of a notification 2620 includes visual obscuring of all or some portions of the notification 2620, as opposed to replacement of all or some portions of the notification 2620 with respective generic text.", "The visual obscuring includes, for example, blacking out (e.g., with censor bars), blurring, or pixelating (e.g., as described above with reference to method 2100).", "In some embodiments, restrictions on access to notification interface 2616 further include an inability of users to open or otherwise access the underlying content or application corresponding to a notification.", "For example, while notification interface 2616 is displayed in full-access mode, a user can perform a gesture (e.g., a tap gesture) on notification 2620-1 to open a messages application and view the full message corresponding to notification 2620-1, perform a gesture on notification 2620-2 to open a calendar application and view the full event invite corresponding to notification 2620-2, and perform a gesture on notification 2620-3 or 2620-4 to open an email application and view the respective full message corresponding to notification 2620-3 or 2620-4, respectively.", "Conversely, while notification interface 2616 is displayed in limited-access mode, these full access features are disabled; gestures detected on notifications 2620 do not activate access to the full content or launch the corresponding application.", "While notification interface 2616 is displayed in limited-access mode, a gesture can be performed by the user to dismiss notification interface 2616.For example, FIGS.", "26C and 26D each show a gesture detected on touch screen 112.The gesture (e.g., a swipe gesture) includes contact 2634 detected on handle 2606, and contact 2634, while detected on handle 2606, moving in direction 2636.In response to detecting the gesture, device 100 displays locked device interface 2600 on touch screen 112, as shown in FIG.", "26F.", "Because no user has been successfully authenticated since device 100 entered into locked mode, device 100 remains in locked mode (and thus displays locked device interface 2600 on touch screen 112).", "In some embodiments, the transition from displaying notification interface 2616 to displaying locked device interface 2600 includes an animation in which notification interface 2616 slides off touch screen 112, following the movement of contact 2634, revealing locked device interface 2600, as shown in FIGS.", "26D-26F; contact 2634 swipes notification interface 2616 off touch screen 112.Continuing in FIG.", "26G, which includes the user interface shown in FIG.", "26C, fingerprint 2640 is detected on fingerprint sensor 169.Device 100 determines if fingerprint 2640 is one of one or more fingerprints enrolled with device 100.If device 100 determines that fingerprint 2640 is not one of the enrolled fingerprints (e.g., the user applying fingerprint 2640 has not been authenticated), then device 100 maintains display of notification interface 2616 in limited-access mode and device 100 maintains itself in locked mode.", "If device 100 determines that fingerprint 2640 is one of the enrolled fingerprints (e.g., the user applying fingerprint 2640 has been successfully authenticated), then device 100 displays notification interface 2616 in full-access mode and device 100 transitions itself from locked mode to unlocked mode, as shown in FIG.", "26H.", "Display of notification interface 2616 in full-access mode includes one or more of the following: un-redacting notifications 2620 that were redacted while notification interface 2616 was displayed in limited-access mode, displaying any section 2618 that was omitted from display while notification interface 2616 was displayed in limited-access mode, and displaying (and making accessible) view filters 2638 that were omitted from display (and thus inaccessible) while notification interface 2616 was displayed in limited-access mode.", "Thus, for example, as shown in FIG.", "26H, notifications 2620 are not redacted; the portions in the respective notifications 2620 display actual content.", "Also, section 2618-2 is displayed (compared to device 100 as depicted in FIG.", "26D).", "Further, view filter “Today” 2638-3 is displayed; when view filter “Today” 2638-3 is activated, the notifications 2620 displayed in notification interface 2616 are notifications for the current day (e.g., messages or mails received on the current day, calendar events for the current day).", "As described above, if fingerprint 2640 is one of the enrolled fingerprints, then device 100 transitions itself from locked mode to unlocked mode.", "The transition includes transitioning from locked device interface 2600 to user interface 400, which takes place below notification interface 2616 because notification interface 2616 is overlaid above locked device interface 2600 and user interface 400.In some embodiments, this transition is not visible to the user (e.g., because notification interface 2616 is opaque).", "In some embodiments, notification interface 2616 is translucent, and thus the transition is visible to the user (e.g., as an animation) but blurred or faint.", "As shown in FIGS.", "26G-26H, when the transition to unlocked mode occurs, user interface elements in locked device interface 2600, such as date/time 2602 and instructions 2604, are no longer displayed below notification interface 2616, and application icons in user interface 400 are displayed below notification interface 2616 instead.", "FIG.", "26I shows notification interface 2616 displayed in full-access mode and device 100 in unlocked mode.", "While notification interface 2616 is displayed in full-access mode and device 100 is in unlocked mode, a gesture is detected on touch screen 112.The gesture (e.g., a swipe gesture) includes contact 2642 detected on handle 2606, and contact 2642, while detected on handle 2606, moving in direction 2644.In response to detecting the gesture, device 100 dismisses notification interface 2616 from touch screen 112, as shown in FIG.", "26J.", "User interface 400 is displayed on touch screen 112, as device 100 remains in unlocked mode after dismissal of notification interface 2616; the user has access to applications that were previously inaccessible because user interface 400 was inaccessible.", "FIG.", "26K summarizes the transition of device 100 (from device 100-a thru 100-d) from locked mode to unlocked mode when notification interface 2616 is displayed, as depicted in FIGS.", "26A-26J.", "Device 100-a is in locked mode and locked device interface 2600 is displayed, and notification interface 2616 is not displayed.", "When display of notification interface 2616 is activated, as shown for device 100-b, locked device interface 2600 is partially visible under a translucent notification interface 2616 that is displayed in limited-access mode.", "When an enrolled fingerprint is detected, device 100 transitions from locked mode to unlocked mode and notification interface 2616 is displayed in full-access mode (device 100-b to device 100-c); locked device interface 2600 transitions to user interface 400.When notification interface 2616, displayed in full-access mode, is dismissed, user interface 400 is displayed on the display of device 100-d.", "FIG.", "26L illustrates locked device interface 2600 displayed on touch screen 112 of device 100; device 100 is in locked mode.", "FIG.", "26L also illustrates a gesture detected on touch screen 112.The gesture (e.g., a swipe gesture) includes contact 2646 detected on handle 2608, and contact 2646, while detected on handle 2608, moving in direction 2648.In response to detecting the gesture, device 100 displays settings-management interface 2650 on touch screen 112, as shown in FIG.", "26N, and device 100 remains in locked mode.", "In some embodiments, the transition from displaying locked device interface 2600 to displaying settings-management interface 2650 includes an animation in which settings-management interface 2650 slides onto touch screen 112 in accordance with the movement of contact 2646, as shown in FIGS.", "26L-26N; contact 2646 swipes settings-management interface 2650 onto touch screen 112.In the animation, settings-management interface 2650 slides over locked screen interface 2600.In some embodiments, notification interface 2616 is opaque, and whatever portion of locked device interface 2600 that is overlaid by settings-management interface 2650 is not visible under settings-management interface 2650, and the portion of locked device interface 2600 not overlaid by settings-management interface 2650 is displayed in the clear or displayed as blurred or faint, as shown in FIG.", "26N, for example.", "In some other embodiments, settings-management interface 2650 is translucent and locked device interface 2600 is visible but blurred or faint under settings-management interface 2650 (e.g., as with notification interface 2616 depicted in FIG.", "26C).", "Settings-management interface 2650 is a user interface associated with one or more device settings on device 100.Settings-management interface 2650 includes user interface objects 2652 for changing respective settings.", "For example, settings-management interface 2650 includes airplane mode icon 2652-1 for toggling airplane mode on/off (when airplane mode is on, device 100 does not transmit wireless signals), Wi-Fi icon 2652-2 for toggling Wi-Fi on or off, Bluetooth icon 2652-3 for toggling Bluetooth on or off, do-not-disturb icon 2652-4 for toggling a do-not-disturb mode on or off (when device 100 is in do-not-disturb mode, audible alerts for notifications 2620 are suppressed, but the notifications themselves are, optionally, still displayed on touch screen 112), and orientation lock icon 2652-5 for toggling an orientation lock on or off.", "A respective icon 2652 indicates the current status of the respective corresponding setting, and toggles the respective corresponding setting in response to activation of (e.g., by a tap gesture on) the respective icon 2652.Settings-management interface 2650 also optionally includes brightness control 2654 for controlling the brightness level of touch screen 112.In some embodiments, settings-management interface 2650 also includes music playback controls 2656 for controlling music playback, icon 2658 for initiating a process for wirelessly sharing a file with another device, icon 2660 for initiating a process for wirelessly streaming media content to another device, and one or more icons 2662 for launching predetermined applications or activating predetermined functionality.", "For example, settings-management interface 2650 includes icon 2662-1 for launching a flashlight application or activating flashlight functionality, icon 2662-2 for launching a clock/timer application, icon 2662-3 for launching a calculator application, and icon 2662-4 for launching a camera application (e.g., camera module 143).", "As device 100 was locked when the gesture with contact 2646 was performed, settings-management interface 2650 is displayed in a limited-access mode.", "While settings-management interface 2650 is in the limited-access mode, one or more of the icons, controls, etc.", "(e.g., any of icons 2652; brightness control 2654; music controls 2656; icons 2658, 2660, and 2662) for changing settings, launching applications, or activating functionality are disabled.", "For example, in FIG.", "26N, icon 2652-1 is disabled.", "Tap gesture 2664 on icon 2652-1 does not toggle, and thus does not affect, the airplane mode.", "In some embodiments, the disablement of an icon 2652 is visually indicated by graying out or shading of the icon (e.g., as with icon 2652-1 in FIG.", "26N).", "While settings-management interface 2650 is displayed in limited-access mode, a gesture can be performed by the user to dismiss settings-management interface 2650, similar to the dismissal of notification interface 2616 as shown in FIGS.", "26C-26F.", "For example, a gesture (e.g., a swipe gesture) on handle 2608 that is the reverse of the gesture with contact 2646 is detected (not shown) on touch screen 112 while settings-management interface 2650 is displayed in limited-access mode; the gesture is detected on handle 2608 and the corresponding contact moves in the direction opposite of direction 2648.In response to detecting the gesture, device 100 displays locked device interface 2600 on touch screen 112, as in FIG.", "26L.", "Because no user has been successfully authenticated since device 100 entered into locked mode, device 100 remains in locked mode (and thus displays locked device interface 2600 on touch screen 112).", "In some embodiments, the transition from displaying settings-management interface 2650 to displaying locked device interface 2600 includes an animation (not shown) in which settings-management interface 2650 slides off touch screen 112, following the movement of contact in the dismissal gesture, revealing locked device interface 2600, similar to the animation shown for the dismissal of notification interface 2616 shown in FIGS.", "26D-26F; the dismissal gesture swipes settings-management interface 2650 off touch screen 112.Returning to FIG.", "26N, fingerprint 2666 is detected on fingerprint sensor 169.Device 100 determines if fingerprint 2666 is one of one or more fingerprints enrolled with device 100.If device 100 determines that fingerprint 2666 is not one of the enrolled fingerprints, then device 100 maintains display of settings-management interface 2650 in limited-access mode and device 100 maintains itself in locked mode.", "If device 100 determines that fingerprint 2666 is one of the enrolled fingerprints, then device 100 displays settings-management interface 2650 in full-access mode and device 100 transitions itself from locked mode to unlocked mode, as shown in FIG.", "26O.", "Display of settings-management interface 2650 in full-access mode includes enabling any icons, controls, etc.", "(e.g., any of icons 2652; brightness control 2654; music controls 2656; icons 2658, 2660, and 2662) that were disabled while settings-management interface 2650 was displayed in limited-access mode.", "For example, in FIG.", "26O, icon 2652-1 is enabled; icon 2652-1 is no longer grayed out.", "Tap gesture 2668 on icon 2652-1 toggles the airplane mode, as shown in FIG.", "26P; in FIG.", "26P, icon 2652-1 changes contrast (compare to icon 2652-1 in FIG.", "26O), indicating that the airplane mode setting has been toggled from the setting in FIG.", "26O.", "As described above, if fingerprint 2666 is one of the enrolled fingerprints, then device 100 transitions itself from locked mode to unlocked mode.", "The transition optionally includes a transition from locked device interface 2600 to user interface 400, taking place below settings-management interface 2650 that is overlaid above locked device interface 2600 and user interface 400.In some embodiments, this transition is not visible to the user.", "In some embodiments, this transition is visible to the user, as an animation of locked device interface 2600 transitioning to user interface 400; settings-management interface 2650 is translucent and/or at most partially covers locked device interface 2600/user interface 400, and thus the animation and interfaces 2600 and 400 are visible, but optionally blurred or faint below settings-management interface 2650.As shown in FIGS.", "26N-26O, when the transition to unlocked mode occurs, user interface elements in locked device interface 2600, such as date/time 2602, are no longer displayed, and application icons in user interface 400 are displayed.", "In some embodiments, user interface 400 is the user interface that was displayed immediately prior to the device entering the locked mode, which may be a different interface from the interface that displays application icons.", "In other words, the interface that displays application icons in FIGS.", "26H-26K and 26O-26R is merely exemplary of an unlocked mode user interface.", "FIG.", "26Q shows settings-management interface 2650 displayed in full-access mode and device 100 in unlocked mode.", "While settings-management interface 2650 is displayed in full-access mode and device 100 is in unlocked mode, a gesture is detected on touch screen 112.The gesture (e.g., a swipe gesture) includes contact 2670 detected on handle 2608, and contact 2670, while detected on handle 2608, moving in direction 2672.In response to detecting the gesture, device 100 dismisses settings-management interface 2650 from touch screen 112, as shown in FIG.", "26R.", "User interface 400 is displayed on touch screen 112, as device 100 remains in unlocked mode after dismissal of settings-management interface 2650; the user has access to applications that were previously inaccessible because user interface 400 was inaccessible.", "FIG.", "26S illustrates locked device interface 2600 displayed on touch screen 112 of device 100; device 100 is in locked mode.", "FIG.", "26S also illustrates a gesture detected on touch screen 112.The gesture (e.g., a swipe gesture) includes contact 2674 detected on icon 2610, and contact 2674, while detected on icon 2610, moving in direction 2676.In response to detecting the gesture, device 100 displays camera interface 2678 on touch screen 112, as shown in FIG.", "26U, and device 100 remains in locked mode.", "In some embodiments, the transition from displaying locked device interface 2600 to displaying camera interface 2678 includes an animation in which camera interface 2678 slides onto touch screen 112 in accordance with the movement of contact 2674, as shown in FIGS.", "26S-26U; contact 2674 swipes camera interface 2678 onto touch screen 112.In the animation, camera interface 2678 slides over locked screen interface 2600.In some embodiments, camera interface 2678 is opaque, and locked device interface 2600 is not visible under camera interface 2678, as shown in FIG.", "26U, for example.", "In some other embodiments, the transition from displaying locked device interface 2600 to displaying camera interface 2678 includes an animation in which locked device interface 2600 slides off of touch screen 112 in accordance with the movement of contact 2674 to reveal camera interface 2678.Camera interface 2678 is an interface associated with a camera application (e.g., camera module 143) on device 100.Camera interface 2678 includes camera preview 2680, flash control 2682, front/back camera toggle 2684, shutter/capture button 2686, image effects control 2688, and camera roll icon 2690.Device 100 ceases to display camera interface 2678 and displays camera roll interface 2693 (FIG.", "26V) in response to detection of gesture 2692 (e.g., a tap gesture) on camera roll icon 2690.Photos 2697 (FIG.", "26W) captured or otherwise stored on device 100 are displayed in camera roll interface 2693.Camera roll interface 2693 also includes icon 2694.In response to activation of icon 2694 (e.g., by a tap gesture on camera icon 2694), device 100 displays camera interface 2678.Thus, camera icon 2694 and camera roll icon 2690 are analogous controls; activation of camera roll icon 2690 switches device 100 to displaying camera roll interface 2693, and activation of icon 2694 switches device 100 to displaying camera interface 2678.As device 100 was locked when the gesture with contact 2674 was performed, camera interface 2678 is displayed in a limited-access mode.", "While camera interface 2678 is in limited-access mode, in response to detection of gesture 2692 on camera roll icon 2690, device 100 replaces display of camera interface 2678 in limited-access mode with display of camera roll interface 2693 in limited-access mode.", "While camera roll interface 2693 is displayed in limited-access mode, display of images captured or otherwise stored on device 100 is restricted.", "In some embodiments, the restrictions include device 100 preventing a user from viewing images that were captured and/or stored on device 100 prior to the device entering locked mode until the user is successfully authenticated; device 100 suppresses display, in camera roll interface 2693, of images captured or stored in the camera roll prior to device 100 entering locked mode.", "Thus, for example, in FIG.", "26V, warning message 2695 is displayed alerting users that not all photos are displayed while camera roll interface 2693 is displayed in limited-access mode, and that the user should unlock device 100 (e.g., authenticate himself) in order to view the hidden photos.", "While camera interface 2678 or camera roll interface 2693 is displayed in limited-access mode, either can be dismissed by a press of button 204 on device 100.In response to detection of a press of button 204 on device 100 while either camera interface 2678 or camera roll interface 2693 is displayed in limited-access mode, device 100 displays locked device interface 2600 on touch screen 112, as in FIG.", "26S, or alternatively, a passcode entry interface (not shown), unless the finger performing the button press has an enrolled fingerprint that is detected by fingerprint sensor 169 during the button press.", "Because no user has been successfully authenticated since device 100 entered into locked mode, device 100 remains in locked mode (and thus displays locked device interface 2600 or a passcode entry interface on touch screen 112).", "If the finger performing the press has an enrolled fingerprint that is detected by fingerprint sensor 169 during the button press, then the user is authenticated, and device 100 displays user interface 400 instead of locked device interface 2600.Returning to device 100 as depicted in FIG.", "26V, fingerprint 2696 is detected on fingerprint sensor 169.Device 100 determines if fingerprint 2696 is one of one or more fingerprints enrolled with device 100.If device 100 determines that fingerprint 2696 is not one of the enrolled fingerprints, then device 100 maintains display of camera roll interface 2693 in limited-access mode and device 100 maintains itself in locked mode.", "Similarly, if a fingerprint is detected on fingerprint sensor 169 while camera interface 2678 is detected, device 100 determines if the fingerprint is one of the enrolled fingerprints.", "If the fingerprint is not one of the enrolled fingerprints, the device 100 maintains display of camera interface 2678 in limited-access mode and device 100 maintains itself in locked mode.", "If device 100 determines that fingerprint 2696 is one of the enrolled fingerprints, then device 100 displays camera roll interface 2693 in full-access mode and device 100 transitions itself from locked mode to unlocked mode, as shown in FIG.", "26W.", "Display of camera roll interface 2693 in full-access mode includes displaying images 2697 that were not displayed while camera roll interface 2693 was displayed in limited-access mode.", "In response to activation of camera icon 2694 (e.g., by tap gesture 2698 on camera icon 2694) while camera roll interface 2693 is displayed in full-access mode, device 100 displays camera interface 2678 in full-access mode and device 100 continues in unlocked mode; switching to camera interface 2678 while camera roll interface 2693 is displayed in full-access mode puts camera interface 2678 in full-access mode.", "While either camera interface 2678 or camera roll interface 2693 is displayed in full-access mode (and device 100 is in unlocked mode), either can be dismissed by a press of button 204 on device 100.In response to detection of a press 2699 of button 204 on device 100 while either camera interface 2678 or camera roll interface 2693 is displayed in full-access mode (e.g., as shown in FIG.", "26W, with camera roll interface 2693 displayed in full-access mode), device 100 displays user interface 400 on touch screen 112, as shown in FIG.", "26X, as device 100 remains in unlocked mode.", "FIGS.", "27A-27D are flow diagrams illustrating a method 2700 of controlling access to device information and features and unlocking the device in accordance with some embodiments.", "The method 2700 is performed at an electronic device (e.g., device 300, FIG.", "3, or portable multifunction device 100, FIG.", "1A) with a display and a touch-sensitive surface.", "In some embodiments, the display is a touch screen display and the touch-sensitive surface is on the display.", "In some embodiments, the display is separate from the touch-sensitive surface.", "Some operations in method 2700 are, optionally, combined and/or the order of some operations is, optionally, changed.", "As described below, the method 2700 provides an intuitive and secure way to control access to device information and features and unlock the device.", "The method reduces the cognitive burden on a user when controlling access to device information and features and unlocking the device, thereby creating a more efficient human-machine interface.", "While the device is in a locked mode in which access to a respective set of features of the electronic device is locked (2702), the device displays (2704) a first user interface on the display, and detects (2706) a first input (e.g., a first gesture in the first user interface such as a downward swipe gesture originating in the top region of the display or at or near an edge of the display).", "In FIG.", "26A and FIG.", "26L, for example, locked device interface 2600 is displayed while device 100 is in locked mode.", "A swipe gesture with contact 2612 and 2646, respectively, is detected on touch screen 112 starting from handle 2606 and 2608, respectively.", "As another example, in FIG.", "26U, camera interface 2678 is displayed while device 100 is in locked mode.", "Tap gesture 2692 is detected on touch screen 112, on camera roll icon 2692.In response to detecting the first input, the device displays (2708) a second user interface on the display, where the second user interface is in a limited-access mode in which access to the second user interface is restricted in accordance with restriction criteria (e.g., at least a portion of the one or more notifications are redacted, the full messages corresponding to notifications can't be accessed without unlocking the device, and/or one or more displayed controls can't be changed).", "For example, in response to detecting the gesture with contact 2612, device 100 displays notification interface 2616 in limited-access mode (FIG.", "26C or 26D); notifications 2620 are redacted.", "As another example, in response to detecting the gesture with contact 2646, device 100 displays settings-management interface 2650 in limited-access mode (FIG.", "26N); airplane mode icon 2652-1 is disabled.", "As another example, in response to detecting gesture 2692, device 100 displays camera roll interface 2693 in limited-access mode (FIG.", "26V); photos 2697 are hidden from display.", "In some embodiments, the second user interface is a user interface selected in accordance with the first input (2710).", "In response to detecting the first input: in accordance with a determination that the first input starts from a first edge of the device, the second user interface is a notification interface; and in accordance with a determination that the second input starts from a second edge of the device that is different from (e.g., opposite to) the first edge of the device, the second interface is a settings-management interface (2712).", "For example, in response to detecting the gesture with contact 2612, which starts on handle 2606 (e.g., starts from the top edge of touch screen 112), notification interface 2616 is displayed in limited-access mode (FIGS.", "26A-26D).", "Conversely, in response to detecting the gesture with contact 2646, which starts on handle 2608 (e.g., starts from the bottom edge of touch screen 112), settings-management interface 2650 is displayed in limited-access mode (FIGS.", "26L-26N).", "While displaying the second user interface in the limited-access mode (2714), the device detects (2716) a first fingerprint on the fingerprint sensor.", "For example, fingerprint 2640 (FIG.", "26G), 2666 (FIG.", "26N), or 2696 (FIG.", "26V) is detected on fingerprint sensor 169.In accordance with a determination that the first fingerprint is one of a plurality of enrolled fingerprints that are enrolled with the device (2718), the device displays (2720) the second user interface in a full-access mode in which access to the second user interface is not restricted in accordance with the restriction criteria (e.g., the one or more notifications are un-redacted), and transitions (2722) the device from the locked mode to an unlocked mode in which the respective set of features of the electronic device is unlocked.", "In some embodiments, a subject line and preview of the notifications are displayed in the un-redacted mode.", "For example, when fingerprint 2640 (FIG.", "26G) is determined to be one of the enrolled fingerprints, notification interface 2616 is displayed in full-access mode and device 100 is unlocked (FIG.", "26H); notifications 2620 are displayed as unredacted.", "As another example, when fingerprint 2666 (FIG.", "26N) is determined to be one of the enrolled fingerprints, settings-management interface 2650 is displayed in full-access mode and device 100 is unlocked (FIG.", "26O); airplane mode icon 2652-1 is enabled.", "As another example, when fingerprint 2696 (FIG.", "26V) is determined to be one of the enrolled fingerprints, camera roll interface 2693 is displayed in full-access mode and device 100 is unlocked (FIG.", "26W); photos 2697 are displayed.", "In some embodiments, the second user interface is translucent, and the second user interface is displayed on top of the first user interface (2724).", "In accordance with the determination that the first fingerprint is one of the plurality of enrolled fingerprints that are enrolled with the device, the device displays (2726) an animation, below the translucent second user interface, of the first user interface for the locked mode of the device transitioning to a user interface for the unlocked mode of the device.", "For example, the first user interface is a lock screen for the device when the device is in a locked mode, and the first user interface transitions to a home screen, a screen with application icons for launching applications, or the last screen displayed by the device in the unlocked mode, just prior to the device going into the locked mode.", "This animated transition is typically blurred because this transition occurs underneath the translucent second user interface.", "This animated transition signals to a user that the device has been unlocked while maintaining display of the second user interface.", "As shown in FIG.", "26C, for example, notification interface 2616 is translucent and displayed over locked device interface 2600.When fingerprint 2640 (FIG.", "26G) is determined to be one of the enrolled fingerprints, an animation transitioning locked device interface 2600 to user interface 400 is displayed under notification interface 2616, as shown in FIGS.", "26G-26H.", "In accordance with a determination that the first fingerprint is not one of the plurality of enrolled fingerprints, the device maintains (2728) display of the second user interface in the limited-access mode and maintains the device in the locked mode.", "For example, when fingerprint 2640 (FIG.", "26G) is determined to not be one of the enrolled fingerprints, device 100 maintains notification interface 2616 in limited-access mode and maintains itself in locked mode; notifications 2620 remain redacted.", "As another example, when fingerprint 2666 (FIG.", "26N) is determined to not be one of the enrolled fingerprints, device 100 maintains settings-management interface 2650 in limited-access mode and maintains itself in locked mode; airplane mode icon 2652-1 remains disabled.", "As another example, when fingerprint 2696 (FIG.", "26V) is determined to not be one of the enrolled fingerprints, device 100 maintains camera roll interface 2693 (and camera interface 2678) in limited-access mode and maintains itself in locked mode; photos 2697 remain hidden from display.", "In some embodiments, after detecting the first input and while displaying the second user interface, the device detects (2730) a second input.", "In response to detecting the second input (2732), the device ceases (2734) to display the second user interface and displays (2736) a respective user interface in place of the second user interface.", "When the device is in the unlocked mode (e.g., in accordance with a determination that the first fingerprint is one of a plurality of enrolled fingerprints that are enrolled with the device), the respective user interface is (2738) a user interface with unrestricted access to the respective set of features of the electronic device (e.g., an application launch user interface for launching a plurality of different applications, or a most recently used application).", "When the device is in the locked mode (e.g., in accordance with a determination that the first fingerprint is not one of the plurality of enrolled fingerprints), the respective user interface is (2740) the first user interface with restricted access to the respective set of features of the electronic device.", "While device 100 is displaying notification interface 2616 or settings-management interface 2650, device 100 detects a respective input to dismiss the respective interface.", "When device 100 is in unlocked mode and the respective interface is dismissed, device 100 displays user interface 400.When device 100 is in locked mode and the respective interface is dismissed, device 100 displays locked device interface 2600.For example, in response to detecting the gesture with contact 2634 to dismiss notification interface 2616 (FIG.", "26C or 26D), device 100 maintains locked mode and displays locked device interface 100.However, in response to detecting the gesture with contact 2642 to dismiss notification interface 2616 (FIG.", "26I), device 100 maintains unlocked mode and displays user interface 400 (FIG.", "26J).", "As another example, in response to detecting a gesture to dismiss settings-management interface 2650 while settings-management interface 2650 is displayed in limited-access mode and device 100 is in locked mode, device 100 maintains locked mode and displays locked device interface 2600.However, in response to detecting the gesture with contact 2670 to dismiss settings-management interface 2650 (FIG.", "26Q), device 100 maintains unlocked mode and displays user interface 400 (FIG.", "26R).", "In some embodiments, the second user interface is (2742) a notification interface that is associated with a plurality of notifications; in the limited-access mode, respective information contained in one or more of the notifications is not accessible; and in the full-access mode, the respective information is accessible.", "As shown in FIGS.", "26C and 26H, notification interface 2616 is displayed with notifications 2620.When notification 2616 is displayed in limited-access mode, as in FIG.", "26C, the actual message or email contents (e.g., snippets of the message or email) are not accessible, and is replaced with generic text in the notifications 2620.However, when notification interface 2616 is displayed in full-access mode, as in FIG.", "26H, the actual message or email contents are included in the notification 2620.In some embodiments, the respective information that is not accessible in the limited-access mode includes redacted information (2744).", "In the limited-access mode, a representation of a respective notification includes a first portion (e.g., a sender identifier) and a second portion (e.g., a subject or content snippet) where the first portion is unredacted and the second portion is redacted.", "In the full-access mode, the representation of the respective notification includes the first portion and the second portion where the first portion and the second portion are unredacted.", "Notification 2620-1 in FIG.", "26C, for example, is a redacted notification; portion 2622 (sender) is not redacted, but portion 2624 (message timestamp) and portion 2626 (message snippet) are redacted by replacement with generic placeholder text.\\ In some embodiments, a notification is not redacted, even in limited access mode, if the notification does not include or involve personal or private information.", "For example, sports updates or news updates notifications need not be redacted.", "In some embodiments, the respective information that is not accessible in the limited-access mode includes information from a predetermined section of the notification interface (2746).", "Tn the limited-access mode, the notification interface omits the predetermined section, and in the full-access mode, the notification interface includes the predetermined section.", "For example, in FIG.", "26D, section 2618-2 for calendar notifications is omitted while notification interface 2616 is in limited-access mode.", "In FIG.", "26H, section 2618-2 for calendar notifications is displayed while notification interface 2616 in full-access mode.", "In some embodiments, the second user interface is (2748) a settings-management interface that is associated with a plurality of device settings.", "In the limited-access mode, the device prevents at least one respective setting from being changed (e.g., the respective setting is fixed at a previously selected value such as “on” or “off” and the device will not respond to user inputs by changing the setting unless/until the second user interface is transitioned to the full-access mode).", "In the full-access mode, the respective setting is enabled to be changed (e.g., the setting is enabled to be changed in response to inputs from the user such as tapping on a setting toggle or sliding a setting slider).", "For example, settings-management interface 2650 is an interface associated with multiple settings (airplane mode on/off, Wi-Fi on/off, etc.).", "When settings-management interface 2650 is in limited-access mode, airplane mode icon 2652-1 is disabled (FIG.", "26N); the current airplane mode setting is unchanged despite tap gesture 2664 on airplane mode icon 2652-1.However, when settings-management interface 2650 is in full-access mode, airplane mode icon 2652-1 is enabled; tap gesture 2668 on airplane mode icon 2652-1 changes the airplane mode setting (FIG.", "26O).", "In some embodiments, the second user interface is (2750) a camera playback interface for viewing images taken by a camera of the device.", "In the limited-access mode the device prevents one or more previously captured images from being viewed in the camera playback interface (e.g., the device prevents a user from viewing images that were captured and placed in a virtual “camera roll” prior to the device entering the locked mode of operation, until the user is successfully authenticated).", "However, in the full-access mode, the one or more previously captured images are enabled to be viewed in the camera playback interface (e.g., after the user has been successfully authenticated, the virtual “camera roll” is unlocked and the user is provided with access to images in the virtual “camera roll”).", "For example, FIGS.", "26V-26W show camera roll interface 2693, for viewing photos captured or otherwise stored on device 100, displayed on touch screen 112.When camera roll interface 2693 is in full-access mode (FIG.", "26W), photos 2697 are displayed.", "When camera roll interface 2693 is in limited-access mode (FIG.", "26V), photos 2697 are not displayed.", "It should be understood that the particular order in which the operations in FIGS.", "27A-27D have been described is merely exemplary and is not intended to indicate that the described order is the only order in which the operations could be performed.", "One of ordinary skill in the art would recognize various ways to reorder the operations described herein.", "Additionally, it should be noted that details of other processes described herein with respect to other methods described herein (e.g., those listed in the “Description of Embodiments” section above) are also applicable in an analogous manner to method 2700 described above with respect to FIGS.", "27A-27D.", "For example, the inputs, user interfaces, user interface objects or elements, and animations described above with reference to method 2700 optionally have one or more of the characteristics of the inputs, user interfaces, user interface objects or elements, and animations described herein with reference to other methods described herein (e.g., those listed in the “Description of Embodiments” section above).", "For brevity, these details are not repeated here.", "In accordance with some embodiments, FIG.", "28 shows a functional block diagram of an electronic device 2800 configured in accordance with the principles of the various described embodiments.", "The functional blocks of the device are, optionally, implemented by hardware, software, or a combination of hardware and software to carry out the principles of the various described embodiments.", "It is understood by persons of skill in the art that the functional blocks described in FIG.", "28 are, optionally, combined or separated into sub-blocks to implement the principles of the various described embodiments.", "Therefore, the description herein optionally supports any possible combination or separation or further definition of the functional blocks described herein.", "As shown in FIG.", "28, an electronic device 2800 includes a display unit 2802, optionally a touch-sensitive surface unit 2804, a fingerprint sensor unit 2806; and a processing unit 2808 coupled to the display unit 2802, optionally touch-sensitive surface unit 2804, and the fingerprint sensor unit 2806.In some embodiments, the processing unit 2808 includes a display enabling unit 2810, a detecting unit 2812, a transitioning unit 2814, a maintaining unit 2816, and a ceasing unit 2818.The processing unit 2808 is configured to: while the device is in a locked mode in which access to a respective set of features of the electronic device is locked, enable display of the first user interface on the display unit 2802 (e.g., with the display enabling unit 2810) and detect a first input (e.g., with the detecting unit 2812); in response to detecting the first input, enable display of a second user interface on the display unit 2802 (e.g., with the display enabling unit 2810), where the second user interface is in a limited-access mode in which access to the second user interface is restricted in accordance with restriction criteria; and while enabling display of the second user interface in the limited-access mode: detect a first fingerprint on the fingerprint sensor unit 2806 (e.g., with the detecting unit 2812); in accordance with a determination that the first fingerprint is one of a plurality of enrolled fingerprints that are enrolled with the device, enable display of the second user interface in a full-access mode in which access to the second user interface is not restricted in accordance with the restriction criteria (e.g., with the display enabling unit 2810), and transition the device from the locked mode to an unlocked mode in which the respective set of features of the electronic device is unlocked (e.g., with the transitioning unit 2814); and in accordance with a determination that the first fingerprint is not one of the plurality of enrolled fingerprints, maintain display of the second user interface in the limited-access mode and maintain the device in the locked mode (e.g., with the maintaining unit 2816).", "In some embodiments, the second user interface is a notification interface that is associated with a plurality of notifications, in the limited-access mode, respective information contained in one or more of the notifications is not accessible, and in the full-access mode, the respective information is accessible.", "In some embodiments, the respective information that is not accessible in the limited-access mode includes redacted information, in the limited-access mode, a representation of a respective notification includes a first portion and a second portion where the first portion is unredacted and the second portion is redacted, and in the full-access mode, the representation of the respective notification includes the first portion and the second portion where the first portion and the second portion are unredacted.", "In some embodiments, the respective information that is not accessible in the limited-access mode includes information from a predetermined section of the notification interface, in the limited-access mode, the notification interface omits the predetermined section, and in the full-access mode, the notification interface includes the predetermined section.", "In some embodiments, the second user interface is a settings-management interface that is associated with a plurality of device settings, in the limited-access mode, the device prevents at least one respective setting from being changed, and in the full-access mode, the respective setting is enabled to be changed.", "In some embodiments, the second user interface is a camera playback interface for viewing images taken by a camera of the device, in the limited-access mode the device prevents one or more previously captured images from being viewed in the camera playback interface, and in the full-access mode, the one or more previously captured images are enabled to be viewed in the camera playback interface.", "In some embodiments, the processing unit 2808 is configured to: after detecting the first input and while enabling display of the second user interface, detect a second input (e.g., with the detecting unit 2812); and in response to detecting the second input: cease to display the second user interface (e.g., with the ceasing unit 2818), and enable display of a respective user interface in place of the second user interface (e.g., with the display enabling unit 2810), wherein: when the device is in the unlocked mode, the respective user interface is a user interface with unrestricted access to the respective set of features of the electronic device, and when the device is in the locked mode, the respective user interface is the first user interface with restricted access to the respective set of features of the electronic device.", "In some embodiments, the second user interface is a user interface selected in accordance with the first input, and in response to detecting the first input: in accordance with a determination that the first input starts from a first edge of the device, the second user interface is a notification interface; and in accordance with a determination that the second input starts from a second edge of the device that is different from the first edge of the device, the second interface is a settings-management interface.", "In some embodiments, the second user interface is translucent, and the second user interface is displayed on top of the first user interface, and the processing unit 2808 is configured to: in accordance with the determination that the first fingerprint is one of the plurality of enrolled fingerprints that are enrolled with the device, enable display of an animation, below the translucent second user interface, of the first user interface for the locked mode of the device transitioning to a user interface for the unlocked mode of the device (e.g., with the display enabling unit 2810).", "The operations in the information processing methods described above are, optionally implemented by running one or more functional modules in information processing apparatus such as general purpose processors (e.g., as described above with respect to FIGS.", "1A and 3) or application specific chips.", "The operations described above with reference to FIGS.", "27A-27D are, optionally, implemented by components depicted in FIGS.", "1A-1B or FIG.", "28.For example, detection operations 2706 and 2716, displaying operations 2704, 2708, and 2720, transitioning operation 2722, and maintaining operation 2728 are, optionally, implemented by event sorter 170, event recognizer 180, and event handler 190.Event monitor 171 in event sorter 170 detects a contact on touch-sensitive display 112, and event dispatcher module 174 delivers the event information to application 136-1.A respective event recognizer 180 of application 136-1 compares the event information to respective event definitions 186, and determines whether a first contact at a first location on the touch-sensitive surface corresponds to a predefined event or sub-event, such as selection of an object on a user interface.", "When a respective predefined event or sub-event is detected, event recognizer 180 activates an event handler 190 associated with the detection of the event or sub-event.", "Event handler 190 optionally utilizes or calls data updater 176 or object updater 177 to update the application internal state 192.In some embodiments, event handler 190 accesses a respective GUI updater 178 to update what is displayed by the application.", "Similarly, it would be clear to a person having ordinary skill in the art how other processes can be implemented based on the components depicted in FIGS.", "1A-1B.", "Unlocking an Application or a Device Depending on Context Many electronic devices have a locked mode in which access to most applications on the device is prevented.", "While in a locked mode, such devices may still permit limited access to a particular application, even though most of the applications on the device are locked.", "In some circumstances, in response to an unlock request, it may be more efficient to unlock the entire device so that a user can navigate to any application on the device.", "In other circumstances, in response to an unlock request, it may be more efficient to unlock just the particular application that is operating in a limited access mode, without unlocking the all of the applications on the device, to enable a user to access more features of the particular application.", "Thus, depending on context, it may be more efficient to unlock an application, rather than unlocking the entire device.", "The methods described herein provide a way to unlock an application or a device, depending on the usage context, in response to detecting an authorized fingerprint on a fingerprint sensor.", "When an authorized fingerprint is detected while a lock screen for the entire device is being displayed, the device transitions to an unlocked mode in which most, if not all, of the applications on the device are accessible.", "In this unlocked mode, the display optionally changes to a home screen, a screen with application icons for launching applications, or the last screen displayed by the device in the unlocked mode, just prior to the device going into the locked mode.", "On the other hand, when an authorized fingerprint is detected while a user interface is being displayed for the particular application that is being used in a limited access mode, the device transitions from the locked mode to a single-application unlocked mode in which previously-locked features of the particular application are unlocked, while other applications on the device remain locked.", "For example, without user authentication, the device may permit limited access to a camera application to enable a user to immediately take photographs.", "In response to fingerprint authentication of the user, the unlocked camera application may also be able to display photographs previously stored on the camera, send photographs to other devices, etc.", "As another example, without user authentication, the device may permit a personal digital assistant (e.g., Siri personal digital assistant from Apple Inc. of Cupertino, Calif.) to answer questions that do not require access to private information for a particular user.", "In response to fingerprint authentication of the user, the personal digital assistant may also be able to answer questions that require access to private information for the particular user.", "In some embodiments, the device is an electronic device with a separate display (e.g., display 450) and a separate touch-sensitive surface (e.g., touch-sensitive surface 451).", "In some embodiments, the device is portable multifunction device 100, the display is touch screen 112, and the touch-sensitive surface includes tactile output generators 167 on the display (FIG.", "1A).", "The device described below with reference to 29A-29Y and 30A-30D includes one or more fingerprint sensors 169.In some embodiments, the one or more fingerprint sensors include one or more integrated fingerprint sensors 359-1 (FIG.", "4B) that are integrated in to the touch-sensitive surface (e.g., separate touch-sensitive surface 451 or touch sensitive display system 112).", "In some embodiments, the one or more fingerprint sensors include separate fingerprint sensors 359-2 (FIG.", "4B) that are separate from the touch-sensitive surface (e.g., separate touch-sensitive surface 451 or touch sensitive display system 112).", "Unless specified otherwise, a fingerprint sensor 169 described below is, optionally, either an integrated fingerprint sensor 359-1 or a separate fingerprint sensor 359-2, depending on the configuration of the hardware and software of the device that includes the fingerprint sensor 169.For convenience of explanation, the embodiments described with reference to FIGS.", "29A-29Y and 30A-30D will be discussed with reference to a device with a touch screen 112 and a separate fingerprint sensor 359-2, however analogous operations are, optionally, performed on a device with an integrated fingerprint sensor 359-1 in response to detecting the inputs described in FIGS.", "29A-29Y on the integrated fingerprint sensor 359-1 while displaying the user interfaces shown in FIGS.", "29A-29Y on the display 450.Additionally, analogous operations are, optionally, performed on a device with a display 450 and a separate touch-sensitive surface 451 instead of a touch screen 112 in response to detecting the contacts described in FIGS.", "29A-29Y on a fingerprint sensor 169 (e.g., an integrated fingerprint sensor 359-1 or a separate fingerprint sensor 359-2) and/or the separate touch-sensitive surface 451 while displaying the user interfaces shown in FIGS.", "29A-29Y on the display 450; in such embodiments, the contacts shown in FIGS.", "29A-29Y optionally represent both a focus selector that corresponds to a location on the display 450, and a contact that corresponds to a location of a contact or gesture performed on the separate touch-sensitive surface (e.g., touch-sensitive surface 451), where the focus selector is, optionally: a respective contact, a representative point corresponding to a contact (e.g., a centroid of a respective contact or a point associated with a respective contact), or a centroid of two or more contacts detected on the touch screen 112 and is, optionally, replaced with a displayed cursor.", "FIG.", "29A illustrates locked device interface 29000 displayed on a display of a device (e.g., on touch screen 112 of device 100).", "Locked device interface 29000 is a user interface that indicates to users of device 100 that device 100 is in locked mode (i.e., device 100 is locked), and thus access to features of multiple applications on device 100 is prevented.", "For example, while device 100 is locked, user interface 400 (FIG.", "29B) is inaccessible.", "Thus, a user is unable to launch multiple some applications on device 100.In some embodiments, locked device interface 29000 provides limited information to users.", "For example, locked device interface 29000 includes current date and time 29002 and instructions or hints 29004 on how to unlock device 100.Locked device interface 29000 also includes one or more user interface objects for displaying respective user interfaces or launching specific applications.", "For example, locked device interface 29000 includes handles 29006 and 29008, and icon 29010.A user performs a gesture (e.g., a swipe gesture) starting from handle 29006 to activate display of a notification interface.", "A user performs a gesture (e.g., a swipe gesture) starting from handle 29008 to activate display of settings-management interface.", "A user performs a gesture (e.g., a swipe gesture) on icon 29010 to activate display of a camera interface.", "FIG.", "29A illustrates fingerprint 29012 detected on fingerprint sensor 169.In response to detecting fingerprint 29012 on fingerprint sensor 169, device 100 determines if fingerprint 29012 is one of one or more fingerprints enrolled with device 100.If fingerprint 29012 is not one of the enrolled fingerprints, device 100 remains in locked mode, and locked device interface 29000 remains displayed or a passcode entry interface (not shown) is displayed.", "If fingerprint 29012 is one of the enrolled fingerprints, device 100 transitions to a multi-application unlocked mode, in which features of multiple applications are unlocked, and user interface 400 is displayed, as shown in FIG.", "29B.", "With user interface 400 displayed and device 100 in multi-application unlocked mode, a user can launch and use any of multiple applications on device 100 with full access.", "For example, FIG.", "29B shows gesture 29014 (e.g., a tap gesture) detected on “Photos” icon 428.In response to detecting gesture 29014, device 100 launches a content presentation application (e.g., a photo viewer application) with full access and displays a corresponding photo viewer interface 29016, as shown in FIG.", "29C.", "In some embodiments, photo viewer interface 29016 corresponds to a camera application as well as, or instead of, a content presentation application.", "In photo viewer interface 29016, photos 29018 stored on device 100 are displayed, including photos previously captured in past sessions of a camera application on device 100 and/or photos received by device 100.In some embodiments, photo viewer interface 29016 includes share icon 29020 for initiating a process for sharing any of photos 29018 by message, email, social network upload, or any other suitable method.", "Share icon 29020 is enabled, as device 100 is in the multi-application unlocked mode.", "While photo viewer interface 29016 is displayed (i.e., the photo viewer application is open), button press 29022 on button 204 is detected by device 100.Button press 29022 includes a button-down (activation) of button 204 and a button-up (deactivation) of button 204.In response to detecting button press 29022, photo viewer interface 29016 ceases to be displayed (e.g., the photo viewer application is dismissed to the background) and user interface 400 is displayed, and device 100 remains in multi-application unlocked mode, as shown in FIG.", "29D.", "FIG.", "29E illustrates device 100 in locked mode with locked device interface 29000 displayed on touch screen 112.A gesture is detected on touch screen 112.The gesture (e.g., a swipe gesture) includes contact 29024 detected on icon 29010, and while detected on icon 29010, moving in direction 29026.In response to detecting the gesture, device 100 displays camera interface 29028 in a limited-access mode on touch screen 112, as shown in FIG.", "29F, and device 100 remains in locked mode.", "Camera interface 29028 is an interface associated with a camera application (e.g., camera module 143) on device 100.Camera interface 29028 includes camera preview 29034, flash control 29030, front/back camera toggle 29032, shutter/capture button 29038, image effects control 29040, and camera roll icon 29036.Device 100 ceases to display camera interface 29028 and displays camera roll interface 29044 in a limited-access mode (FIG.", "29G) in response to detection of gesture 29042 (e.g., a tap gesture) on camera roll icon 29036.While camera roll interface 29044 is displayed in limited-access mode, photos captured on device 100 in previous sessions of the camera application are not displayed in camera roll interface 29044.For example, in FIG.", "29G, instead of photos displayed in camera roll interface 29044, message 29046 directing the user to unlock the device to view the captured photos is displayed.", "Camera roll interface 29044 also includes share icon 29020 that is disabled and camera icon 29048.In some embodiments, share icon 29020 is grayed out or shaded when it is disabled.", "Device 100 ceases to display camera roll interface 29044 and displays camera interface 29028 in response to detection of a gesture (e.g., a tap gesture) on camera icon 29048, which is not disabled.", "In FIG.", "29G, fingerprint 29050 is detected on fingerprint sensor 169.If device 100 determines that fingerprint 29050 is one of the enrolled fingerprints, then device 100 transitions into a single-application unlock mode with respect to the application corresponding to camera roll interface 29044 and unlocks the features of camera roll interface 29044, including display of photos captured on device 100 in previous sessions of the camera application.", "As shown in FIG.", "29H, photos 29018 are displayed in unlocked camera roll interface 29044.Also, share icon 29020 is enabled in the single-application unlock mode, as shown in FIG.", "29H.", "If fingerprint 29050 is not one of the enrolled fingerprints, then the features of camera roll interface 29044 remain restricted.", "In some embodiments, transitioning device 100 to the single-application unlocked mode with respect to camera roll interface 29044 includes device 100 unlocking just the camera application to which camera roll interface 29044 corresponds and making the features of that application unlocked and accessible, while leaving the other applications on device 100 locked and their features inaccessible.", "In some other embodiments, transitioning device 100 to the single-application unlocked mode with respect to camera roll interface 29044 includes transitioning device 100 into an unlocked mode with respect to multiple applications (i.e., features of multiple applications are unlocked, including the camera application to which camera roll interface 29044 corresponds), but device 100 is also configured to transition back to locked mode (i.e., features of the multiple applications are locked and inaccessible) as soon as the camera application is closed.", "Thus, in these embodiments, even though multiple applications are unlocked, just the camera and the camera roll are accessible, which effectively makes this a single-application unlocked mode.", "Returning to FIG.", "29H, while the features of camera roll interface 29044 are unlocked, button press 29052 on button 204 is detected by device 100.Button press 29052 includes a button-down (activation) of button 204 and a button-up (deactivation) of button 204.In response to detecting button press 29052, camera roll interface 29044 ceases to be displayed (e.g., the camera application or the content presentation application is closed) and locked device interface 29000 is displayed, and device 100 returns to locked mode, as shown in FIG.", "29I.", "FIG.", "29J illustrates another example of transitioning device 100 to a single-application unlocked mode with respect to camera roll interface 29044.In FIG.", "29J, camera roll interface 29044 is in limited-access mode (i.e., its features are restricted), device 100 is in locked mode, and photos 29054 captured in a current session of the camera application are displayed in camera roll interface 29044.In FIG.", "29J, other photos stored on device 100, besides the photos 29054 captured in a current session of the camera application, are not displayed.", "Also, share icon 29020 is disabled; gesture (e.g., a tap gesture) 29055 on share icon 29020 has no effect.", "Fingerprint 29056 (FIG.", "29J) is detected on fingerprint sensor 169.If device 100 determines that fingerprint 29056 is one of the enrolled fingerprints, then device 100 transitions to a single-application unlock mode and unlocks the features of camera roll interface 29044, including enabling share icon 29020.As shown in FIGS.", "29K-29L, in response to detecting gesture (e.g., a tap gesture) 29058 on share icon 29020, device 100 initiates a process for sharing one or more of the photos displayed in camera roll interface 29044 (e.g., photos 29054).", "(For simplicity, this example assumes that captured photos 29054-1-29054-4 are all of the photos stored on the device.)", "The sharing process includes, for example, displaying photo selection interface 29060 (FIG.", "29L), where the user selects the photos to share, and displaying an interface for the user to select a method of sharing (e.g., email, message, social network, microblog) (not shown).", "If fingerprint 29056 is not one of the enrolled fingerprints, then the features of camera roll interface 29044 remain restricted.", "Before the sharing process is completed, the user can close the corresponding content presentation application or camera application, and thus cancel the sharing process.", "For example, in FIG.", "29L, while photo selection interface 29060 is displayed, button press 29066 on button 204 is detected by device 100.Button press 29066 includes a button-down (activation) of button 204 and a button-up (deactivation) of button 204.In response to detecting button press 29066, photo selection interface 29060 ceases to be displayed (e.g., the camera application or the content presentation application is closed) and locked device interface 29000 is displayed, and device 100 is in locked mode, as shown in FIG.", "29M.", "FIG.", "29N illustrates passcode entry interface 29068 displayed on touch screen 112 while device 100 is in locked mode.", "In some embodiments, passcode entry interface 29068 is displayed in response to, for example, detection of a horizontal swipe gesture in proximity of unlock instructions 29004 while locked device interface 29000 is displayed.", "Passcode entry interface 29068 includes passcode field 29070 and keypad 29072.Keypad 29072 includes “Emergency call” key 29073.In response to detecting gesture (e.g., a tap gesture, a virtual-key press gesture) 29074 on “Emergency call” key 29073, device 100 displays emergency call interface 29076, and device 100 remains in locked mode, as shown in FIG.", "29O.", "Emergency call interface 29076 is an interface corresponding to a phone application on device 100.A user can make emergency calls (e.g., calls to recognized official emergency phone numbers, such as 911, 999, etc.", "; calls to contacts designated in device 100 as “in case of emergency” (“ICE”) contacts) but not non-emergency calls (e.g., calls to non-emergency phone numbers) from emergency call interface 29076.Also, other features of the phone application (e.g., contacts, call history, voicemail, contact favorites or speed-dial) are not accessible from emergency call interface 29076.Emergency call interface 29076 includes, for example, phone number field 29078, keypad 29080, cancel icon 29082, and call icon 29084.While emergency call interface 29076 is displayed, fingerprint 29086 is detected on fingerprint sensor 169.As depicted in FIGS.", "29O-29P, fingerprint 29086 includes fingerprint-down 29086-a and fingerprint-liftoff 29086-b.", "If device 100 determines that fingerprint 29086 is one of the enrolled fingerprints, then in response to detecting fingerprint-liftoff 29086-b, device 100 transitions to a single-application unlock mode with respect to the phone application and unlocks the features of the phone application.", "As a result of unlocking the features of the phone application, emergency call interface 29076 ceases to be displayed, and instead interfaces for the full-access phone application (e.g., keypad interface 29088 with phone icons 29096) are displayed, as shown in FIG.", "29Q.", "If fingerprint 29086 is not one of the enrolled fingerprints, then the features of the phone application remain locked and emergency call interface 29076 remains displayed.", "FIG.", "29Q illustrates device 100 displaying keypad interface 29088 after the features of the phone application are unlocked.", "Keypad interface 29088 includes, for example, phone number field 29078, keypad 29090, and icons 29096 for accessing the features of the phone application.", "Keypad 29090 includes conference call key 29092, which was not present in keypad 29080 in emergency call interface 29076.Icons 29096 include, for example, favorites icon 29096-1, call history icon 29096-2, contacts icon 29096-3, keypad icon 29096-4, and voicemail icon 29096-5.In response to detecting gesture (e.g., a tap gesture) 29098 on contacts icon 29096-3, device 100 ceases to display keypad interface 29088 and displays contacts interface 29100, as shown in FIG.", "29R.", "Contacts interface 29100 is accessible now that the features of the communication interface are unlocked.", "Contacts interface 29100 includes, for example, a list of contacts 29102 that the user can view and edit.", "Continuing in FIG.", "29R, while contacts interface 29100 is displayed, button press 29104 on button 204 is detected by device 100.Button press 29104 includes a button-down (activation) of button 204 and a button-up (deactivation) of button 204.In response to detecting button press 29104, contacts interface 29100 ceases to be displayed (i.e., the phone application is closed) and locked device interface 29000 is displayed, and device 100 is in locked mode, as shown in FIG.", "29S.", "FIG.", "29T illustrates device 100 in locked mode with locked device interface 29000 displayed on touch screen 112.Button press 29106 is detected on button 204, and a fingerprint corresponding to button press 29106 is detected on fingerprint sensor 169 integrated with button 204.The button press includes button-down 29106-a and button-up 29106-b (FIG.", "29V).", "During button-down 29106-a, fingerprint sensor 169 detects the fingerprint corresponding to button press 29106 and determines if the fingerprint is one of the enrolled fingerprints.", "Also, in response to button-down 29106-a continuing and lasting for more than a predetermined amount of time (e.g., 2 seconds), personal assistant interface 29108 is displayed in limited-access mode, as shown in FIG.", "29U; some features of the corresponding personal assistant application are locked.", "Personal assistant interface 29108 corresponds to a personal assistant application.", "The personal assistant application is voice controlled, and can perform various operations in response to voice commands from the user.", "For example, the personal assistant application can perform web searches; display news, weather, and sports scores; read email and messages; inform the user of outstanding appointments or events, and compose email and messages in accordance with user dictation.", "Personal assistant interface 29108 optionally includes prompt 29109 to prompt the user to speak a command or request.", "After personal assistant interface 29108 is displayed, button-up 29106-b is detected.", "In response to detecting button-up 29106-b, if the fingerprint corresponding to button press 29106 is determined by device 100 to be one of the enrolled fingerprints, device 100 transitions to a single-application unlocked mode with respect to the personal assistant application and the features of the personal assistant application are unlocked; and if the fingerprint corresponding to button press 29106 is determined by device 100 to not be one of the enrolled fingerprints, some features of the personal assistant application remain locked.", "While personal assistant interface 29108 is displayed and after button-up 29106-b, the personal assistant application is standing by for commands or requests from the user, and the user speaks a command or request to device 100, as in FIG.", "29V.", "Commands/requests 29110 from the user and responses 29112 from the personal assistant application are displayed in personal assistant interface 29108 for the user to view.", "If some features of the personal assistant application remain locked in response to button-up 29106-b, then commands or requests involving personal or private information (e.g., play voicemail, compose a message, make a call) are not fulfilled by the personal assistant interface (because these features of the personal assistant application are locked).", "For example, in FIG.", "29W, in response to command 29110-1 “Play my voicemail,” response 29112-1 from the personal assistant application is “Sorry I can't do that.” In some embodiments, if a command or request does not involve personal or private information (e.g., the command is to display a sports score), then the personal assistant interface answers the command or request.", "If the features of the personal assistant application are unlocked in response to button-up 29106-b, then the personal assistant application fulfills commands or requests involving personal or private information (e.g., play voicemail, compose a message, make a call), as well as commands/request not involving personal or private information.", "For example, in FIG.", "29X, in response to command 29110-2 “Play my voicemail,” response 29112-2 from the personal assistant application is “You have two voicemails.", "Playing .", ".", ".", "” and playback of the voicemails by device 100.The personal assistant application can be closed by a press of button 204.For example, in response to detecting button press 29114 (FIG.", "29W) or button press 29116 (FIG.", "29X), personal assistant interface 29108 cease to be displayed, and locked device interface 29000 is displayed, as shown in FIG.", "29Y.", "In both FIG.", "29W and FIG.", "29X, device 100 is not fully unlocked (in FIG.", "29W, features of multiple applications are still locked; in FIG.", "29X, device 100 is in a single-application unlocked mode with respect to the personal assistant application), and thus locked device interface 29000 is displayed.", "FIGS.", "30A-30D are flow diagrams illustrating a method 3000 of unlocking an application or a device depending on context in accordance with some embodiments.", "The method 3000 is performed at an electronic device (e.g., device 300, FIG.", "3, or portable multifunction device 100, FIG.", "1A) with a display and a touch-sensitive surface.", "In some embodiments, the display is a touch screen display and the touch-sensitive surface is on the display.", "In some embodiments, the display is separate from the touch-sensitive surface.", "Some operations in method 3000 are, optionally, combined and/or the order of some operations is, optionally, changed.", "As described below, the method 3000 provides an intuitive way to unlock an application or a device depending on context.", "The method reduces the cognitive burden on a user when unlocking, thereby creating a more efficient human-machine interface.", "For battery-operated electronic devices, enabling a user to unlock more efficiently conserves power and increases the time between battery charges.", "While the electronic device is (3002) in a locked mode in which access to features of a plurality of different applications on the electronic device is prevented, the device displays (3004) a first user interface on the display.", "The first user interface is one of: a locked-device user interface for the electronic device, and a limited-access user interface for a respective application in the plurality of different applications.", "In some embodiments, the features of applications on the electronic device include features of a first application and features of a second application.", "In some embodiments, features of a respective application include one or more of: the ability to access and interact with content associated with the application (e.g., viewing photos in a camera roll of a camera application, viewing contacts in an address book application, viewing messages in a messaging application), the ability to instruct the application to perform application-specific operations on the device (e.g., taking pictures in a camera application, downloading content in a web browser or app store application, playing media in an media player application, sending and receiving messages in a messaging application).", "For example, device 100 displays locked device interface 29000 (FIG.", "29A).", "Alternatively, the device displays a limited-access user interface for an application, such as camera roll interface 29044 (FIG.", "29G or FIG.", "29J), emergency call interface 29076 (FIGS.", "29O-29P), or personal assistant interface 29108 (FIG.", "29U).", "While these interfaces are displayed, an input (fingerprint 29012, FIG.", "29A; fingerprint 29050, FIG.", "29G; fingerprint 29056, FIG.", "29J; fingerprint 29086, FIGS.", "29O-29P; the fingerprint corresponding to button press 29106, FIG.", "29U; respectively) to initiate unlocking features of the device is detected with fingerprint 169.The device detects (3006), with the fingerprint sensor, a first input (e.g., fingerprint 29012, FIG.", "29A; fingerprint 29050, FIG.", "29G; fingerprint 29056, FIG.", "29J; fingerprint 29086, FIGS.", "29O-29P; or the fingerprint corresponding to button press 29106, FIG.", "29U; respectively) that corresponds to a request to initiate unlocking one or more features of the device (and that meets unlock criteria).", "For example, the first input includes a fingerprint that matches an enrolled fingerprint that was previously enrolled with the device.", "In some embodiments, when the device detects an input that includes a fingerprint that does not match an enrolled fingerprint that was previously enrolled with the device, the device ignores the input (e.g., by maintaining the device in the locked mode of operation) and/or displays an alternative method of authorizing unlocking the device, such as a passcode entry user interface.", "In response to detecting, with the fingerprint sensor, the first input that corresponds to the request to initiate unlocking one or more features of the device (3008), in accordance with a determination that the first user interface is the locked-device user interface for the electronic device, the device transitions (3010) the device from the locked mode to a multi-application unlocked mode in which the features of the plurality of different applications are unlocked.", "For example, in FIGS.", "29A-29B, when the interface displayed is locked device interface 29000, in response to detecting fingerprint 29012 that is an enrolled fingerprint, device 100 transitions to a multi-application unlocked mode and user interface 400 is displayed; device 100 is fully unlocked.", "However, in response to detecting, with the fingerprint sensor, the first input that corresponds to the request to initiate unlocking one or more features of the device (3008), in accordance with a determination that the first user interface is the limited-access user interface for the respective application, the device (3012) transitions the device from the locked mode to a single-application unlocked mode in which one or more previously-locked features of the respective application are unlocked, and continues to prevent access to one or more previously-locked features of other applications in the plurality of different applications (e.g., features of the other applications, besides the respective application, that are locked when the device is in the locked mode).", "For example, in FIG.", "29G, device 100 displays camera roll interface 29044 in limited-access mode, and in response to detecting fingerprint 29050 that is an enrolled fingerprint, features of camera roll interface 29044 are unlocked but access to features of other applications are prevented (FIG.", "29H).", "As another example, in FIG.", "29J, device 100 displays camera roll interface 29044 in limited-access mode, and in response to detecting fingerprint 29056 that is an enrolled fingerprint, features of camera roll interface 29044 are unlocked but access to features of other applications are prevented (FIG.", "29K).", "As another example, in FIGS.", "29O-29P, device 100 displays emergency call interface 29076 of a phone application in limited-access mode, and in response to detecting fingerprint 29050 that is an enrolled fingerprint, features of the phone application are unlocked (e.g., keypad interface 29088 is displayed; FIG.", "29Q), but access to features of other applications are prevented.", "As another example, in FIG.", "29U.", "device 100 displays personal assistant interface 29108 of a personal assistant application in limited-access mode, and in response to detecting the fingerprint, that is an enrolled fingerprint, corresponding to button press 29106, features of the personal assistant application are unlocked (e.g., access to private information is unlocked so that command 29110-2, which involves personal or private information, is fulfilled; FIG.", "29X), but access to features of other applications are prevented.", "In some embodiments, transitioning the device from the locked mode to the single-application unlocked mode and continuing to prevent access to previously-locked features of other applications includes (3014) unlocking the one or more previously-locked features of the respective application without unlocking the one or more previously-locked features of the other applications in the plurality of different applications (e.g., without unlocking all of the features of the plurality of different applications).", "For example, only features of the respective application are unlocked while features of other applications in the plurality of different applications are not unlocked.", "In FIGS.", "29G-29H or FIGS.", "29J-29K, for example, the features of the content presentation application or camera application are unlocked but features of other applications on device 100 are still locked.", "In FIGS.", "29O-29Q, the features of the phone application are unlocked but features of other applications on device 100 are still locked.", "In FIGS.", "29T-29V and 29X, the features of the personal assistant application are unlocked but features of other applications on device 100 are still locked.", "In some embodiments, transitioning the device from the locked mode to the single-application unlocked mode and preventing access to previously-locked features of other applications includes (3016): transitioning the device from the locked mode to an unlocked mode in which access to the features of the plurality of different applications are unlocked, and configuring the device to transition from the unlocked mode to the locked mode upon detection of a request to close the respective application (e.g., when the device is in the single-application unlocked mode, the whole device is an unlocked mode, however if/when the user requests to exit the respective application, the device transitions back to the locked mode, so that the user is restricted to performing unlocked operations within the respective application).", "Thus, in FIGS.", "29G-29H or FIGS.", "29J-29K, alternatively, device 100 is unlocked in response to fingerprint 29050 and 29056, respectively, and device 100 is locked again when the content presentation application or camera application is closed.", "In FIGS.", "29O-29Q, alternatively, device 100 is unlocked in response to fingerprint 29086, and device 100 is locked again when the phone application is closed.", "In FIGS.", "29T-29V and 29X, alternatively, device 100 is unlocked in response to the fingerprint corresponding to button press 29106, and device 100 is locked again when the personal assistant application is closed.", "In some embodiments, after detecting the first input, while displaying a user interface for the respective application, the device detects (3018) a second input that includes a request to close the respective application.", "In response to detecting the second input (3020), when the device is in the single-application unlocked mode, the device returns (3022) the device to the locked mode of operation; and when the device is in the multi-application unlocked mode, the device closes (3024) the respective application and maintains the device in the unlocked mode of operation.", "For example, while photo viewer interface 29016 is displayed in multi-application unlock mode, in response to detecting button press 29022, the corresponding content presentation application is closed and device 100 remains unlocked (FIGS.", "29C-29D).", "On the other hand, while camera roll interface 29044 is displayed in single-application unlock mode, in response to detecting button press 29052, the corresponding content presentation application or camera application is closed and device 100 returns to locked mode (FIGS.", "29H-291).", "As another example, while photo selection interface 29060 is displayed in single-application unlock mode, in response to detecting button press 29066, the corresponding content presentation application or camera application is closed and device 100 returns to locked mode (FIGS.", "29L-29M).", "As another example, while contacts interface 29100 is displayed in single-application unlock mode, in response to detecting button press 29104, the corresponding phone application is closed and device 100 returns to locked mode (FIGS.", "29R-29S).", "As another example, while personal assistant interface 29108 is displayed in single-application unlock mode, in response to detecting button press 29114 or 29116, the corresponding personal assistant application or camera application is closed and device 100 returns to locked mode (FIGS.", "29W-29Y).", "In some embodiments, detecting the first input includes detecting liftoff of a fingerprint from the fingerprint sensor, and the response to the first input is performed in response to detecting liftoff of the fingerprint from the fingerprint sensor (3026).", "For example, in FIGS.", "29O-29Q, the transition to the single-application unlock mode with respect to the phone application is performed in response to fingerprint-liftoff 29086-b.", "In some embodiments, the fingerprint sensor is (3028) integrated into a button; detecting the first input includes detecting activation of the button (e.g., detecting a button-down signal), detecting a fingerprint on the fingerprint sensor, and detecting deactivation of the button (e.g., detecting a button-up signal) (e.g., while continuing to detect the fingerprint on the fingerprint sensor); and the response to the first input is performed in response to detecting deactivation of the button (e.g., the response to the first input is performed in response to detecting the button-up signal).", "For example, FIGS.", "29T-29V depict fingerprint sensor 169 as integrated into button 204.In FIGS.", "29T-29V, the input is button press 29106 that includes button-down 29106-a that activates button 204, detection of the fingerprint corresponding to button press 29106, and button-up 29106-b that deactivates the button.", "The transition to the single-application unlock mode (or not) is performed in response to detecting button-up 29106-b.", "In some embodiments, the respective application is opened (3030) in response to detecting activation of the button (e.g., the device opens a personal digital assistant application in response to detecting a button down event, or in response to detecting a button down event and then continuing to detect the button down for more than a predetermined time threshold such as 0.2, 0.5, 1, 2 seconds, or some other reasonable time threshold).", "For example, device 100 opens the personal assistant application (e.g., displays personal assistant interface 29108) in response to detecting button-down 29106-a for at least a predetermined amount of time (FIGS.", "29T-29U).", "In some embodiments, in conjunction with detecting activation of the button (e.g., immediately before, during and/or immediately after detecting activation of the button), the device obtains (3032) fingerprint information about a fingerprint of a finger that is on the fingerprint sensor and determining whether the fingerprint information matches an enrolled fingerprint that was previously enrolled with the device.", "For example, in FIG.", "29T, during button-down 29106-a, device 100 obtains information for the fingerprint corresponding to button press 29106 and determines if that fingerprint is an enrolled fingerprint.", "In some embodiments, the respective application is (3034) a personal assistant application (e.g., a voice-controlled personal assistant application that is launched with a long press of a button in which the fingerprint sensor is integrated), and the one or more previously-locked features of the respective application that are unlocked in the single-application unlocked mode include features that require the personal assistant application to access data for a particular user stored on the device (e.g., while the device is in the locked mode, the personal assistant application can perform certain functions such as performing web searches or providing directions that do not require access to private information for a particular user but is prevented/disabled from performing other functions such as reading messages, accessing an address book, and/or accessing calendar information that require access to private information for the particular user).", "For example, in FIGS.", "29T-29X, the application is a personal assistant application, and a feature that is unlocked in response to determining that the fingerprint corresponding to button press 29106 is an enrolled fingerprint is that the personal assistant application can access personal or private information (and therefore can fulfill requests and command such as playing voicemail).", "In some embodiments, the respective application is (3036) a camera application, and the one or more previously-locked features of the respective application that are unlocked in the single-application unlocked mode include features that enable the device to display images that were previously captured by a camera of the device (e.g., photos in a “photo roll” of the camera of the device).", "For example, in FIGS.", "29G-29H, the application is a camera application, and a feature that is unlocked in response to determining that fingerprint 29050 is an enrolled fingerprint is that previously captured or stored photos 29018 are displayed in camera roll interface 29044.In some embodiments, the respective application is (3038) a content presentation application (e.g., a camera application with a media viewing feature such as a photo roll that displays photos that were previously captured by the camera), and the one or more previously-locked features of the respective application that are unlocked in the single-application unlocked mode include features that enable the device to share content associated with the content presentation application (e.g., sharing photos in a -photo roll” of a camera via email, a MMS message, or a message on a social networking service).", "For example, in FIGS.", "29J-29K, the application is a content presentation application (or a camera application), and a feature that is unlocked in response to determining that fingerprint 29056 is an enrolled fingerprint is that share icon 29020 in camera roll interface 29044 is enabled.", "In some embodiments, the respective application is (3040) a communication application (e.g., a phone application), the one or more previously-locked features of the respective application that are unlocked in the single-application unlocked mode include features that enable a user of the device to communicate with an arbitrary contact specified by the user (e.g., calling a non-emergency phone number).", "For example, in FIGS.", "29O-29Q, the application is a phone application, and a feature that is unlocked in response to determining that fingerprint 29086 is an enrolled fingerprint is that keypad interface 29088, from which the user can call an arbitrary phone number, is accessible.", "In some embodiments, the respective application is (3042) a communication application (e.g., a phone application), and the one or more previously-locked features of the respective application that are unlocked in the single-application unlocked mode include features that enable the device to access a user-specific directory of communication information (e.g., while the device is locked, access to the user's address book is disabled).", "For example, in FIGS.", "29O-29R, the application is a phone application, and a feature that is unlocked in response to determining that fingerprint 29086 is an enrolled fingerprint is that contacts interface 29100 is accessible.", "It should be understood that the particular order in which the operations in FIGS.", "30A-30D have been described is merely exemplary and is not intended to indicate that the described order is the only order in which the operations could be performed.", "One of ordinary skill in the art would recognize various ways to reorder the operations described herein.", "Additionally, it should be noted that details of other processes described herein with respect to other methods described herein (e.g., those listed in the “Description of Embodiments” section above) are also applicable in an analogous manner to method 3000 described above with respect to FIGS.", "30A-30D.", "For example, the fingerprints, gestures, and user interface objects described above with reference to method 3000 optionally have one or more of the characteristics of the fingerprints, gestures, and user interface objects described herein with reference to other methods described herein (e.g., those listed in the “Description of Embodiments” section above).", "For brevity, these details are not repeated here.", "In accordance with some embodiments, FIG.", "31 shows a functional block diagram of an electronic device 3100 configured in accordance with the principles of the various described embodiments.", "The functional blocks of the device are, optionally, implemented by hardware, software, or a combination of hardware and software to carry out the principles of the various described embodiments.", "It is understood by persons of skill in the art that the functional blocks described in FIG.", "31 are, optionally, combined or separated into sub-blocks to implement the principles of the various described embodiments.", "Therefore, the description herein optionally supports any possible combination or separation or further definition of the functional blocks described herein.", "As shown in FIG.", "31, an electronic device 3100 includes a display unit 3102 configured to display a first user interface, optionally a touch-sensitive surface unit 3104 configured to receive contacts, a fingerprint sensor unit 3106; and a processing unit 3108 coupled to the display unit 3102, optionally the touch-sensitive surface unit 3104, and the fingerprint sensor unit 3106.In some embodiments, the processing unit 3108 includes a display enabling unit 3110, a detecting unit 3112, a transitioning unit 3114, an access preventing unit 3116, a returning unit 3118, a closing unit 3120, an obtaining unit 3122, and a determining unit 3124.The processing unit 3108 is configured to: while the electronic device is in a locked mode in which access to features of a plurality of different applications on the electronic device is prevented: enable display (e.g., with the display enabling unit 3110) of the first user interface on the display unit 3102, the first user interface being one of: a locked-device user interface for the electronic device, and a limited-access user interface for a respective application in the plurality of different applications; and detect (e.g., with the detecting unit 3112), with the fingerprint sensor, a first input that corresponds to a request to initiate unlocking one or more features of the device.", "The processing unit 3108 is further configured to, in response to detecting, with the fingerprint sensor, the first input that corresponds to the request to initiate unlocking one or more features of the device: in accordance with a determination that the first user interface is the locked-device user interface for the electronic device, transition (e.g., with the transitioning unit 3114) the device from the locked mode to a multi-application unlocked mode in which the features of the plurality of different applications are unlocked.", "The processing unit 3108 is also configured to, in accordance with a determination that the first user interface is the limited-access user interface for the respective application: transition (e.g., with the transitioning unit 3114) the device from the locked mode to a single-application unlocked mode in which one or more previously-locked features of the respective application are unlocked; and continue to prevent access (e.g., with the access preventing unit 3116) to one or more previously-locked features of other applications in the plurality of different applications.", "In some embodiments, transitioning the device from the locked mode to the single-application unlocked mode and continuing to prevent access to previously-locked features of other applications includes unlocking the one or more previously-locked features of the respective application without unlocking the one or more previously-locked features of the other applications in the plurality of different applications.", "In some embodiments, transitioning the device from the locked mode to the single-application unlocked mode and preventing access to previously-locked features of other applications includes: transitioning the device from the locked mode to an unlocked mode in which access to the features of the plurality of different applications are unlocked; and configuring the device to transition from the unlocked mode to the locked mode upon detection of a request to close the respective application.", "In some embodiments, the processing unit 3108 is configured to: after detecting the first input, while enabling display of a user interface for the respective application, detect (e.g., with the detecting unit 3112) a second input that includes a request to close the respective application; and in response to detecting the second input: when the device is in the single-application unlocked mode, return (e.g., with the returning unit 3118) the device to the locked mode of operation; and when the device is in the multi-application unlocked mode, close (e.g., with the closing unit 3120) the respective application and maintaining the device in the unlocked mode of operation.", "In some embodiments, detecting the first input includes detecting liftoff of a fingerprint from the fingerprint sensor; and the response to the first input is performed in response to detecting liftoff of the fingerprint from the fingerprint sensor.", "In some embodiments, the fingerprint sensor is integrated into a button; detecting the first input includes detecting activation of the button, detecting a fingerprint on the fingerprint sensor, and detecting deactivation of the button; and the response to the first input is performed in response to detecting deactivation of the button.", "In some embodiments, the respective application is opened in response to detecting activation of the button.", "In some embodiments, the processing apparatus 3108 is configured to, in conjunction with detecting activation of the button, obtain (e.g., with the obtaining unit 3122) fingerprint information about a fingerprint of a finger that is on the fingerprint sensor and determine (e.g., with the determining unit 3124) whether the fingerprint information matches an enrolled fingerprint that was previously enrolled with the device.", "In some embodiments, the respective application is a personal assistant application, and the one or more previously-locked features of the respective application that are unlocked in the single-application unlocked mode include features that require the personal assistant application to access data for a particular user stored on the device.", "In some embodiments, the respective application is a camera application, and the one or more previously-locked features of the respective application that are unlocked in the single-application unlocked mode include features that enable the device to display images that were previously captured by a camera of the device.", "In some embodiments, the respective application is a content presentation application, and the one or more previously-locked features of the respective application that are unlocked in the single-application unlocked mode include features that enable the device to share content associated with the content presentation application.", "In some embodiments, the respective application is a communication application, and the one or more previously-locked features of the respective application that are unlocked in the single-application unlocked mode include features that enable a user of the device to communicate with an arbitrary contact specified by the user.", "In some embodiments, the respective application is a communication application, and the one or more previously-locked features of the respective application that are unlocked in the single-application unlocked mode include features that enable the device to access a user-specific directory of communication information.", "The operations in the information processing methods described above are, optionally implemented by running one or more functional modules in information processing apparatus such as general purpose processors (e.g., as described above with respect to FIGS.", "1A and 3) or application specific chips.", "The operations described above with reference to FIGS.", "30A-30D are, optionally, implemented by components depicted in FIGS.", "1A-1B or FIG.", "31.For example, displaying operation 3004, detection operation 3006, transitioning operation 3010, and transitioning and access preventing operations operation 3012 are, optionally, implemented by event sorter 170, event recognizer 180, and event handler 190.Event monitor 171 in event sorter 170 detects a contact on touch-sensitive display 112, and event dispatcher module 174 delivers the event information to application 136-1.A respective event recognizer 180 of application 136-1 compares the event information to respective event definitions 186, and determines whether a first contact at a first location on the touch-sensitive surface corresponds to a predefined event or sub-event, such as selection of an object on a user interface.", "When a respective predefined event or sub-event is detected, event recognizer 180 activates an event handler 190 associated with the detection of the event or sub-event.", "Event handler 190 optionally utilizes or calls data updater 176 or object updater 177 to update the application internal state 192.In some embodiments, event handler 190 accesses a respective GUI updater 178 to update what is displayed by the application.", "Similarly, it would be clear to a person having ordinary skill in the art how other processes can be implemented based on the components depicted in FIGS.", "1A-1B.", "The foregoing description, for purpose of explanation, has been described with reference to specific embodiments.", "However, the illustrative discussions above are not intended to be exhaustive or to limit the invention to the precise forms disclosed.", "Many modifications and variations are possible in view of the above teachings.", "The embodiments were chosen and described in order to best explain the principles of the invention and its practical applications, to thereby enable others skilled in the art to best use the invention and various described embodiments with various modifications as are suited to the particular use contemplated.", "As described above, one aspect of the present technology is the gathering and use of data available from various sources to improve the delivery to users of invitational content or any other content that may be of interest to them.", "The present disclosure contemplates that in some instances, this gathered data may include personal information data that uniquely identifies or can be used to contact or locate a specific person.", "Such personal information data can include demographic data, location-based data, telephone numbers, email addresses, home addresses, or any other identifying information.", "The present disclosure recognizes that the use of such personal information data, in the present technology, can be used to the benefit of users.", "For example, the personal information data can be used to deliver targeted content that is of greater interest to the user.", "Accordingly, use of such personal information data enables calculated control of the delivered content.", "Further, other uses for personal information data that benefit the user are also contemplated by the present disclosure.", "The present disclosure further contemplates that the entities responsible for the collection, analysis, disclosure, transfer, storage, or other use of such personal information data will comply with well-established privacy policies and/or privacy practices.", "In particular, such entities should implement and consistently use privacy policies and practices that are generally recognized as meeting or exceeding industry or governmental requirements for maintaining personal information data private and secure.", "For example, personal information from users should be collected for legitimate and reasonable uses of the entity and not shared or sold outside of those legitimate uses.", "Further, such collection should occur only after receiving the informed consent of the users.", "Additionally, such entities would take any needed steps for safeguarding and securing access to such personal information data and ensuring that others with access to the personal information data adhere to their privacy policies and procedures.", "Further, such entities can subject themselves to evaluation by third parties to certify their adherence to widely accepted privacy policies and practices.", "Despite the foregoing, the present disclosure also contemplates embodiments in which users selectively block the use of, or access to, personal information data.", "That is, the present disclosure contemplates that hardware and/or software elements can be provided to prevent or block access to such personal information data.", "For example, in the case of advertisement delivery services, the present technology can be configured to allow users to select to “opt in” or “opt out” of participation in the collection of personal information data during registration for services.", "In another example, users can select not to provide location information for targeted content delivery services.", "In yet another example, users can select to not provide precise location information, but permit the transfer of location zone information.", "Therefore, although the present disclosure broadly covers use of personal information data to implement one or more various disclosed embodiments, the present disclosure also contemplates that the various embodiments can also be implemented without the need for accessing such personal information data.", "That is, the various embodiments of the present technology are not rendered inoperable due to the lack of all or a portion of such personal information data.", "For example, content can be selected and delivered to users by inferring preferences based on non-personal information data or a bare minimum amount of personal information, such as the content being requested by the device associated with a user, other non-personal information available to the content delivery services, or publically available information." ] ]
Patent_15872685
[ [ "Moldable Fly-Away Tool Structure System", "A composite structure includes a first face sheet, a second face sheet, and a foam member located between the first face sheet and the second face sheet.", "The foam member has a molded contour, the mold contour being configured to provide tooling surface for at least one of the first face sheet and the second face sheet prior to curing of the composite structure.", "A method of making the foam member includes creating a mold tool having an interior surface which resembles the desired outer contour of the foam member.", "A mixture is poured into a pour opening in the mold tool.", "The mixture is allowed to polymerize into a foam as the foam expands and distributes within the mold tool.", "Vent openings in the mold tool are selectively tailored to control the density of the foam member.", "The foam member is cured in the mold tool." ], [ "1.A method of making a foam member for a rigid composite structure, comprising: creating a mold tool having an interior surface which resembles the desired outer contour of the foam member; pouring a liquid mixture into a pour opening in the mold tool; allowing the liquid mixture to polymerize into a foam so as to expand and distribute within the mold tool; selectively configuring one or more vent openings in the mold tool so as to selectively dictate the density of the foam member so as to tailor a strength of the foam member so that the foam member is able to rigidly support a skin member during a subsequent curing cycle of the skin member; and curing the foam member in the mold tool.", "2.The method according to claim 1, wherein the one or more vent openings are located near the extremities of the mold tool.", "3.The method according to claim 1, wherein the one or more vent openings are located in a lid member of the mold tool.", "4.The method according to claim 1, further comprising: applying a release agent in the mold tool prior to pouring the liquid mixture into the pour opening.", "5.The method according to claim 1, wherein the selectively configuring the one or more vent openings allow volatiles to escape during expansion of the liquid mixture into the foam.", "6.The method according to claim 1, wherein the selectively configuring the one or more vent openings includes selectively sizing a diameter of the vent openings.", "7.The method according to claim 1, wherein the selectively configuring the one or more vent openings includes selectively generating a quantity of the one or more vent openings.", "8.A method of making a composite structure, comprising: providing an uncured composite lower face sheet; providing an uncured composite upper face sheet; providing an at least partially cured foam member, the foam member being rigid by having a foam body of uninterrupted foam, an outer molded surface of the foam member being an outer surface of the foam body; laying up the uncured composite lower face sheet onto a surface; positioning the foam member at a desired location on the lower face sheet; laying up the uncured composite upper face sheet onto the lower face sheet and the foam member so that the outer molded surface of the foam member supports a portion of the upper face sheet at a desired geometry; and curing the composite lower face sheet and the composite upper face sheet while the foam member supports the portion of the upper face sheet.", "9.The method according to claim 8, wherein the step of providing the at least partially cured foam member comprises: creating a mold tool having an interior surface which resembles the desired outer molded surface of the foam member; pouring a mixture into a pour opening in the mold tool; allowing the mixture to polymerize into a foam as the foam expands and distributes within the mold tool; selectively configuring one or more vent openings in the mold tool so as to selectively control the density of the foam member; and curing the foam member in the mold tool.", "10.The method according to claim 8, further comprising: selectively tailoring a volume of the mixture to correspond with the density of the foam member.", "11.The method according to claim 8, further comprising: applying an adhesive between the lower face sheet and the foam member, as well as between the upper face sheet and the foam member.", "12.The method according to claim 8, wherein the selectively configuring one or more vent openings in the mold tool includes locating the one or more vent openings near an extremity of the mold tool." ], [ "<SOH> BACKGROUND <EOH>" ], [ "BACKGROUND 1.Field of the Invention The system of the present application relates composite structure.", "In particular, the system of the present application relates to an efficient method for generating stiffness in a composite structure.", "2.Description of Related Art Composite structures are often used in aerospace, in part due to the high strength to weight ratio, and desirable fatigue qualities.", "Structural characteristics of the composite structure, such as stiffness and area moment of inertia, can be tailored through a variety of methods.", "One common method is use a cellular core material, such as honeycomb core, between an upper and lower face sheet.", "Another common method is to bond two separately cured composite parts together, thus forming a composite structure assembly.", "Referring to FIG.", "1, a composite structure 101 is illustrated.", "The composite structure 101 includes an upper sheet 103, a lower sheet 105, and a honeycomb core member 107 bonded therebetween.", "Honeycomb core member 107 typically includes a plurality of cells forming a repeating geometric pattern or tessellation.", "Honeycomb core member 107 is sometimes carved to the desired contour before being assembled with upper sheet 103 and lower sheet 105.The upper sheet 103 and lower sheet 105 are composite materials that are typically cured with heat and/or pressure, while assembled with honeycomb core member 107, to form composite structure 101.Use of a honeycomb core, such as honeycomb core member 107, is common for tailoring the stiffness of composite structures.", "However, limitations of honeycomb core make it less than desirable in certain situations.", "For example, the height dimension of the core is one limitation due to the tendency of a tall and narrow core to collapse edgewise when exposed to curing pressure in the curing cycle.", "Further, shaping core to complex contours is labor intensive and contributes to the possibility of the honeycomb core destabilizing during assembly and curing.", "Further, it is difficult to accurately control the surface tolerances of the both the upper sheet 103 and lower sheet 105.Even further, the upper sheet 103 and lower sheet 105 sometimes sag into the cells of the honeycomb core member 107 during curing, thus producing dimples in upper sheet 103 and lower sheet 105.Referring to FIG.", "2, a composite structure 201 is illustrated.", "Composite structure 201 includes a hat stiffener 205 bonded to a face sheet 203, the hat stiffener 205 is used to provide desired stiffness to composite structure 201.Typically, face sheet 203 is formed from composite plies laid-up on a tooled surface.", "The composite plies are then at least partially cured.", "Hat stiffener 205 is separately laid-up on tooled surface, and then also at least partially cured.", "The hat stiffener 205 and face sheet 203 are then assembled and bonded together with an adhesive in an additional curing cycle.", "As such, manufacturing composite structure 201 typically requires separate unique hand lay-up procedures, a plurality of tools, and three separate curing cycles.", "The complexity and labor involved in manufacturing composite structure 201 causes the high cost of composite structure 201 to be very undesirable.", "Although the developments in composite structures have produced significant improvements, considerable shortcomings remain.", "DESCRIPTION OF THE DRAWINGS The novel features believed characteristic of the embodiments of the present application are set forth in the appended claims.", "However, the embodiments themselves, as well as a preferred mode of use, and further objectives and advantages thereof, will best be understood by reference to the following detailed description when read in conjunction with the accompanying drawings, wherein: FIG.", "1 is a cross-sectional view of a prior art structural system; FIG.", "2 is cross-sectional view of another prior art structural system; FIG.", "3 is a perspective view of a structural system according to the preferred embodiment of the present application; FIG.", "4 is a cross-sectional view of the structural system, according to the preferred embodiment of present application, taken along the section lines IV-IV, shown in FIG.", "3; FIG.", "5 is a cross-sectional view of the structural system, according to the preferred embodiment of present application, taken along the section lines V-V, shown in FIG.", "3; FIG.", "6 is a cross-sectional view of the structural system, according to the preferred embodiment of present application, taken along the section lines VI-VI, shown in FIG.", "3; FIGS.", "7A-7F are perspective views which illustrated the process for manufacturing a molded foam member, according to the preferred embodiment of present application; FIG.", "8 is a schematic view of components of the foam system used to manufacture the molded foam member, according to the preferred embodiment of present application; FIG.", "9 is a perspective view of a mixer used to mix the foam system, according to the preferred embodiment of present application; FIG.", "10 is a schematic view of a mixture of the foam system used to manufacture the molded foam member, according to the preferred embodiment of present application; FIG.", "11 is a cross-sectional view of an uncured preform of the structural system, according to the preferred embodiment of present application; and FIG.", "12 is a cross-sectional view of a structural system, according to an alternative embodiment of present application.", "While the system and method of the present application is susceptible to various modifications and alternative forms, specific embodiments thereof have been shown by way of example in the drawings and are herein described in detail.", "It should be understood, however, that the description herein of specific embodiments is not intended to limit the invention to the particular embodiment disclosed, but on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the process of the present application as defined by the appended claims.", "DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT Illustrative embodiments of the system of the present application are described below.", "In the interest of clarity, not all features of an actual implementation are described in this specification.", "It will of course be appreciated that in the development of any such actual embodiment, numerous implementation-specific decisions must be made to achieve the developer's specific goals, such as compliance with system-related and business-related constraints, which will vary from one implementation to another.", "Moreover, it will be appreciated that such a development effort might be complex and time-consuming but would nevertheless be a routine undertaking for those of ordinary skill in the art having the benefit of this disclosure.", "In the specification, reference may be made to the spatial relationships between various components and to the spatial orientation of various aspects of components as the devices are depicted in the attached drawings.", "However, as will be recognized by those skilled in the art after a complete reading of the present application, the devices, members, apparatuses, etc.", "described herein may be positioned in any desired orientation.", "Thus, the use of terms such as “above,” “below,” “upper,” “lower,” or other like terms to describe a spatial relationship between various components or to describe the spatial orientation of aspects of such components should be understood to describe a relative relationship between the components or a spatial orientation of aspects of such components, respectively, as the device described herein may be oriented in any desired direction.", "Referring to FIGS.", "3-6, a composite structure 301, according to the preferred embodiment of the present application, is illustrated.", "Composite structure 301 includes a first face sheet 303, a second face sheet 305, and a molded foam member 307.Molded foam member 307 provides structural stiffness to composite structure 301.First face sheet 303 and second face sheet 305 preferably comprise a plurality of reinforcing fibers disposed in a polymeric matrix.", "As discussed further herein, first face sheet 303 and second face sheet 305 are preferably assembled as a plurality of uncured composite plies, and then later cured to form a rigid composite laminate.", "In an alternative embodiment, one or both of first face sheet 303 and second face sheet 305 are cured prior to assembly with molded foam member 307.It should be appreciated that first face sheet 303 and second face sheet 305 can be formed from a variety of fiber and resin systems.", "It should also be appreciated that the specific composite material is implementation specific.", "For example, carbon fiber may be desirable in one application, while fiberglass fiber may be desirable in another application.", "In the preferred embodiment, first face sheet 303 and second face sheet 305 completely enclose molded foam member 307, as shown in FIG.", "4.However, alternative embodiments of composite structure 301 may be configured with foam member 307 partly exposed.", "Referring briefly to FIG.", "12, an alternative embodiment composite structure 1201 is illustrated.", "Composite structure 1201 is similar to composite structure 301, except that a first face sheet 1201 does not completely envelope a foam member 1207.Foam member 1207 is substantially similar to foam member 307.In one embodiment, foam member 1207 is molded in strips that are positioned onto second face sheet 305.Side portions 1205 of foam member 1207 are left exposed.", "In contrast to composite structure 301, composite structure 1201 is particularly well suited for implementations which the predicted loading does not require the structural joining of first face sheet 1203 and second face sheet 305.The molded foam member 307 is preferably formed with a pourable and expandable structural foam in a mold, as discussed further herein.", "The molded foam member 307 is preferably cured prior to assembly with the first face sheet 303 and second face sheet 305.The molded foam member 307 is configured to provide the structural integrity to composite structure 301 in a wide variety of geometries and contours.", "Molded foam member 307 is particular useful in providing structural stiffness in portions of composite structure 301 where narrow and slender stiffener geometry is required.", "Curing of composite structure 301 may require pressure, such as autoclave curing pressure, in order to properly cure the first face sheet 303 and second face sheet 305.As such, molded foam member 307 is configured to provide structural resistance to the pressure so as to preserve the desired geometry around molded foam member 307.In contrast, tall and narrow portions of honeycomb core are very susceptible to collapsing when subjected to autoclave pressure and temperature.", "For example, a honeycomb core portion hypothetically having a height of H1 and width of W1 of foam member 307, would likely crush inward along directions A1, A2, and A3, when subjected to autoclave pressure and temperature.", "However, foam member 307 is configured to be isotropic, unlike honeycomb core.", "As such, the isotropic properties of foam member 307 allow it to retain structural integrity in a wide variety of geometries and contours.", "Still referring to FIGS.", "3-6, composite structure 301 can optionally also include a honeycomb core member 309 to provide structural stiffness in areas of relative simple geometry and contour.", "For example, FIG.", "5 depicts a portion of composite structure 301 with honeycomb core member 309 being used to provide stiffness.", "Further, FIG.", "6 depicts a section of composite structure 301 where molded foam member 309 and honeycomb core member 309 abut adjacently.", "An adhesive may be used to bond molded foam member 309 to honeycomb core member 309.It may be desirable to use honeycomb core for structural stiffness where the geometry is relatively simple, while using molded foam wherein the geometry prohibits the use of honeycomb core.", "However, it should be fully appreciated that molded foam member 307 may be used in lieu of honeycomb core member 309 such that honeycomb core material is not required.", "Referring now to FIGS.", "7A-7F, the process for manufacturing molded foam member 309 is illustrated.", "A master tool 701 is fabricated having the desired geometry of foam member 307, as depicted in FIG.", "7A.", "Master tool 701 can be formed from a variety of materials and techniques.", "For example, master tool 701 can be formed from a selective laser sintering process.", "Referring to FIG.", "7B, a mold tool 703 is derived from the master tool 701.Preferably, a base member 705 of mold tool 703 is manufactured by assembling and curing composite plies on master tool 701.It should also be appreciated that base member 705 of mold tool 703 can be manufacturing without master tool 701; for example, the geometry and contours of foam member 307 can be machined directly into base member 705.Mold tool 703 also includes a lid member 707 (shown in FIGS.", "7C, 7D, and 7E) configured to be releasably coupled to base member 705, thereby forming a cavity from which foam member 307 is molded.", "Referring to FIGS.", "7C and 7D, a foam mixture 807 (shown in FIG.", "10) is poured into a pour opening 711.The pour opening 711 is preferably in a central location so that the foam mixture 807 expands and flows evenly to the extremities of the part.", "In an alternative embodiment, the foam mixture 807 is distributed into the depression area of base member 705.Then, lid member 707 is attached to the base member 705 with one or more fastening members 709 soon after the pour operation is completed.", "One or more vent openings, such as vent openings 713a and 713b, are preferably located near the extremities of the part in order to allow for any volatiles to escape during the polymerization stage, and also to facilitate complete homogeneous mold fill.", "The polymerization stage is the expansion from a chemical reaction of the foam mixture 807.A release agent is preferably applied to the interior of mold tool 703 in order to promote the release and removal of foam member 307 from the mold tool 703.Referring briefly to FIGS.", "8-10, the foam system used in the creation of foam member 307 is preferably a urethane foam system that expands to fill mold tool 703.Upon curing, the foam is preferably rigid and flexible, while having a relatively low density.", "The preferred foam system is a polyisocyanurate pour foam system marketed under the name of Stepanfoam BX 450, by the Stepan Chemical Company.", "It should be fully appreciated that other foam systems may be used in the molding of molded foam member 307.The Stepanfoam BX 450 includes two separate resin components, namely a resin T (70% by weight) 805 and a resin R (30% by weight) 803.The desired weight amounts of resin T 805 and resin R 803 are measured and poured into a container 801.The resin T 805 and resin R 803 are mechanically agitated to form a homogenous mixture 807.A mixer 901 is used in rotation in order to mix resin T 805 and resin R 803 to form mixture 807.Mixer 901 includes a shaft 903, the shaft 903 being configured to be driven by a drill motor, or the like.", "Mixer 901 also includes a plurality of blades located on a first blade disc 905 and a second blade disc 907.In the preferred embodiment, mixer 901 is rotated at 3500 revolutions per minute for 10-15 seconds when mixing resin T 805 and resin R 803 to form mixture 807.Once the mixing is complete, it is preferred that mixture 807 is poured into mold tool 703 as quickly as possible.", "The pouring of mixture 807 is discussed further herein.", "The total weight amount of mixture 807 is at least partially dependent upon the desired density and the volume of foam member 307.For example, because density is the relationship is mass per unit volume, the desired density of foam member 307 at least partially dictates the weight amount of mixture 807.However, a small portion of the mixture 807 may escape through openings 711, 713a, and 713b, which affects the final density of foam member 307.In the preferred embodiment, a “captive process” uses openings 711, 713a, and 713b to allow volatiles to escape during the polymerization of mixture 807, while also creating a desired pressure within mold 703.Pressure within mold 703 inhibits expansion of foam mixture 807 during the polymerization process, thereby increasing the density of the foam member 307.As such, the size and number of openings 711, 713a, and 713b are configured so as to selectively tailor the density of foam member 807.For example, the openings 711, 713a, and 713b in mold tool 703 create a foam member 307 having a density of approximately 12-16 pounds/ft3.However, this size and quantity of openings 711, 713a, and 713b can be increased to produce a foam member 307 of lower density.", "In an alternative embodiment, mold 703 may be void of lid member 707 so that the foam mixture 807 is allowed to “free rise” within the base member 705.In the “free-rise” embodiment, a density of approximately 8.0 pounds/ft3 and less can be achieved.", "The “free rise” embodiment of foam member 307 may be particularly desirable when the geometry and contours of foam member 307 are relatively simple.", "This is because the exposed surface would require a cutting or shaving operation to trim the exposed surface of foam member 307 to the desired contour.", "The density of foam member 307 is preferably customized in accordance with the specific implementation of a foam member 307 in composite structure 301.For example, one type of composite structure 301 may require a higher curing pressure as compared to another composite structure 301; therefore, a foam member 307 used in the composite structure that requires a higher curing pressure may be manufactured having a high density so as to withstand the higher curing pressure of composite structure 101.In one embodiment, composite structure 301 is configured such that the foam member 307 minimally performs the function of physical supporting of first face sheet 303 and second face sheet 305 before and during the curing cycle.", "In such an embodiment, foam member 307 acts as a “fly-away tool” such that it acts as a tool during the assembly and curing of composite structure 301, but also remains with the composite structure 301 during operation of the aircraft.", "It should be appreciated that composite structure 301 may also be used in vehicles and structures other than aircraft.", "Further, when foam member 307 acts simply as a “fly-away tool”, a release member may be applied during the assembly of composite structure 301 to prevent bonding contact between first face sheet 303, second face sheet 305, and foam member 307.The expected operational loading of composite structure 101 is another factor that may contribute to the customization of the density of foam member 307.The density of foam member 307 can be customized in accordance with the desired structural strength of foam member 307.For example, in one embodiment of composite structure 101, foam member 307 may be configured to provide a structural load path between first face sheet 303 and second face sheet 305.In such an embodiment, first face sheet 303 and second face sheet 305 are preferably each in bonding contact with foam member 307.The bonding contact can be created with the resin from each first face sheet 303 and second face sheet 305.The bonding contact can also be created or supplemented with an adhesive layer located between each of the first face sheet 303, second face sheet 305 and foam member 307.The bonding contact facilitates the structural load transfer between first face sheet 303, second face sheet 305, and foam member 307, in a variety of load path directions.", "Referring to FIG.", "7E, foam member 307 is illustrated while in the base member 705 of mold tool 703.Lid member 707 is removed for clarity.", "A full cure of foam member is preferred before foam member 307 is removed from base member 705 of mold tool 703.The full cure is achieved by first allowing the foam member 307 to remain within mold tool 703 for at least 24 hours after the expanding of the foam mixture 807 within mold tool 703.Thereafter, the mold tool 703, with foam member 307 remaining therein, is cured between 350° F. and 375° F. for two hours.", "It should be appreciated that alternative foam systems may require different curing requirements.", "Referring to FIG.", "7F, foam member 307 is illustrated separated from mold tool 703.It is preferred that foam member 307 and mold tool 703 is cooled to 150° F. or below, before demolding.", "Demolding of foam member 307 may require pliable tools to facilitate separation of the foam member 307 from mold tool 703.Once foam member 307 is removed from mold tool 703, then foam member 307 can be assembled with the first face sheet 303 and second face sheet 305 in a composite manufacturing process in order to form composite structure 301.The geometry and contours of foam member 307 are accurate to a high tolerance because of being molded in mold tool 703.Referring to FIG.", "11, an uncured preform 1107 of composite structure 301 is illustrated.", "It should be appreciated that the composite manufacturing process may take on a wide variety of processes in part because first face sheet 303 and second face sheet 305 may be formed from a wide variety of composite fiber/resin systems.", "For example, in one exemplary embodiment, the composite manufacturing process includes creating preform 1107 by first laying a plurality of pre-impregnated fiber patterns on a surface of a tool 1101, so as form first uncured layer 1101.Next, the foam member 307 is placed at the desired location on layer 1103.Next, a plurality of pre-impregnated fiber patterns are laid upon layer 1103 and foam member 307 to form layer 1105.Foam member 307 acts as a tool by dictating the geometry of layer 1105.Because foam member 307 was formed in a mold tool, the geometry and contours are highly accurate.", "As such, foam member 307 acts as a high tolerance in the support of layer 1105.Next, the preform 1107 may be vacuum bagged and cured in accordance with one of a variety of conventional composite curing processes.", "After final curing, preform 1107 becomes composite structure 301.The system of the present application provides significant advantages, including: (1) providing a stiffness producing foam member in a composite structure that can be molded in a variety of geometries and contours; (2) providing a stiffness producing foam member in a composite structure that can withstand autoclave curing pressure; (3) providing a stiffness producing foam member in a composite structure, the density of the foam member selectively tailored; (4) providing a stiffness producing foam member in a composite structure that provides continuous support for an upper face sheet such that the foam member prevents sagging of the upper face sheet; and (5) providing a stiffness producing foam member in a composite structure that provides continuous support for an upper face sheet such that the foam member prevents sagging of the upper face sheet.", "The particular embodiments disclosed above are illustrative only, as the application may be modified and practiced in different but equivalent manners apparent to those skilled in the art having the benefit of the teachings herein.", "Furthermore, no limitations are intended to the details of construction or design herein shown, other than as described in the claims below.", "It is therefore evident that the particular embodiments disclosed above may be altered or modified and all such variations are considered within the scope and spirit of the application.", "Accordingly, the protection sought herein is as set forth in the claims below.", "It is apparent that a system with significant advantages has been described and illustrated.", "Although the system of the present application is shown in a limited number of forms, it is not limited to just these forms, but is amenable to various changes and modifications without departing from the spirit thereof." ] ]
Patent_15872706
[ [ "MOLDED FLUID FLOW STRUCTURE", "A method of manufacturing a fluid flow structure may include coupling a flex circuit to a carrier.", "The flex circuit may include at least one conductor.", "The method may include coupling an orifice side of a fluidic die to the carrier at an opening on the carrier.", "The fluidic die may include at least one electrical terminal.", "The method may include coupling the electrical terminal to the conductor, and overmolding the fluid flow structure with a moldable material.", "The overmolded fluid flow structure may include a channel molded therein, and the channel may be fluidically coupled to the fluidic die.", "The conductor may be surrounded by the moldable material." ], [ "1.A method of manufacturing a fluid flow structure, comprising: coupling a flex circuit to a carrier, the flex circuit comprising at least one conductor; coupling an orifice side of a fluidic die to the carrier at an opening on the carrier, the fluidic die comprising at least one electrical terminal; coupling the electrical terminal to the conductor; overmolding the fluid flow structure with a moldable material, the overmolded fluid flow structure comprising a channel molded therein, the channel being fluidically coupled to the fluidic die, wherein the conductor is surrounded by the moldable material.", "2.The method of claim 1, wherein the channel is formed in the moldable material using a molding tool.", "3.The method of claim 1, comprising releasing the carrier from the fluidic die.", "4.The method of claim 3, wherein the fluidic die is coupled to the carrier using a thermal release tape.", "5.The method of claim 4, wherein releasing the carrier from the fluidic die comprises applying heat to the thermal release tape.", "6.The method of claim 1, wherein the fluidic die comprises: a substrate; at least one fluid port defined in the substrate, the fluid port extending from a first surface of the substrate to a second surface of the substrate; and an orifice plate coupled to the second side of the substrate.", "7.The method of claim 6, wherein the orifice plate comprises: a manifold fluidically coupled to the fluid port; a number of fluid ejection chambers fluidically coupled to the manifold; and a number of orifices fluidically coupled to the fluid ejection chambers through which fluid is ejected from the fluidic die.", "8.The method of claim 6, wherein the orifice plate is monolithic.", "9.The method of claim 6, wherein the orifice plate comprises a plurality of layers, the plurality of layers comprising: a manifold layer comprising: a number of manifold passageways fluidically coupled to the fluid port; and a number of fluid ejection chambers; and an orifice plate comprising a number of orifices fluidically coupled to the fluid ejection chambers through which fluid is ejected from the fluidic die.", "10.A method of manufacturing a fluid flow structure, comprising: coupling an orifice side of a fluidic die to a carrier at an opening on the carrier, the fluidic die comprising at least one electrical terminal; coupling the electrical terminal to a conductor coupled to the carrier; monolithically overmolding the fluid flow structure with a moldable material, the overmolded fluid flow structure comprising a channel molded therein, the channel being fluidically coupled to the fluidic die; releasing the carrier from the fluidic die; and wherein the conductor is surrounded by the moldable material.", "11.The method of claim 10, comprising overmolding a plurality of the fluid flow structures into a common wafer.", "12.The method of claim 11, wherein the plurality of fluid flow structures overmolded onto the common wafer in a pattern.", "13.The method of claim 12, wherein the pattern of the plurality of fluid flow structures overmolded onto the wafer matches a pattern of a plurality of the conductors.", "14.The method of claim 10, wherein the channel s formed in the moldable material using a molding tool.", "15.The method of claim 10, comprising releasing the carrier from the fluidic die.", "16.The method of claim 15, wherein the fluidic die is coupled to the carrier using a thermal release tape.", "17.The method of claim 16, wherein releasing the carrier from the fluidic die comprises applying heat to the thermal release tape.", "18.The method of claim 10, wherein the fluidic die is formed by: defining at least one fluid port in a substrate, the fluid port extending from a first surface of the substrate to a second surface of the substrate; and coupling an orifice plate to the second side of the substrate.", "19.The method of claim 18, wherein the orifice plate is formed by: fluidically coupling a manifold to the fluid port; fluidically coupling a number of fluid ejection chambers to the manifold; and fluidically coupling a number of orifices led to the fluid ejection chambers.", "20.The method of claim 18, wherein the orifice plate is monolithic or comprises a plurality of layers." ], [ "<SOH> BACKGROUND <EOH>Each printhead die in an inkjet pen or print bar includes tiny channels that carry ink to the ejection chambers.", "Ink is distributed from the ink supply to the die channels through passages in a structure that supports the printhead die(s) on the pen or print bar.", "It may be desirable to shrink the size of each printhead die, for example to reduce the cost of the die and, accordingly, to reduce the cost of the pen or print bar.", "The use of smaller dies, however, can require changes to the larger structures that support the dies, including the passages that distribute ink to the dies." ], [ "RELATED DOCUMENTS The present application is a continuation and claims the benefit under 35 U.S.C.", "§ 120, of U.S. application Ser.", "No.", "14/769,994, filed Aug. 24, 2015, which claims benefit under 35 U.S.C.", "§ 371 and is the National Stage Entry of International Application No.", "PCT/US2013/028207, filed Feb. 28, 2013.These applications are herein incorporated by reference in their entireties.", "BACKGROUND Each printhead die in an inkjet pen or print bar includes tiny channels that carry ink to the ejection chambers.", "Ink is distributed from the ink supply to the die channels through passages in a structure that supports the printhead die(s) on the pen or print bar.", "It may be desirable to shrink the size of each printhead die, for example to reduce the cost of the die and, accordingly, to reduce the cost of the pen or print bar.", "The use of smaller dies, however, can require changes to the larger structures that support the dies, including the passages that distribute ink to the dies.", "DRAWINGS Each pair of FIGS.", "1/2, 3/4, 5/6, and 7/8 illustrate one example of a new molded fluid flow structure in which a micro device is embedded in a molding with a fluid flow path directly to the device.", "FIG.", "9 is a block diagram illustrating a fluid flow system implementing a new fluid flow structure such as one of the examples shown in FIGS.", "1-8.FIG.", "10 is a block diagram illustrating an inkjet printer implementing one example of a new fluid flow structure for the printheads in a substrate wide print bar.", "FIGS.", "11-16 illustrate an inkjet print bar implementing one example of a new fluid flow structure for a printhead die, such as might be used in the printer of FIG.", "10.FIGS.", "17-21 are section views illustrating one example of a process for making a new printhead die fluid flow structure.", "FIG.", "22 is a flow diagram of the process shown in FIGS.", "17-21.FIGS.", "23-27 are perspective views illustrating one example of a wafer level process for making a new inkjet print bar such as the print bar shown in FIGS.", "11-16.FIG.", "28 is a detail from FIG.", "23.FIGS.", "29-31 illustrate other examples of a new fluid flow structure for a printhead die.", "The same part numbers designate the same or similar parts throughout the figures.", "The figures are not necessarily to scale.", "The relative size of some parts is exaggerated to more clearly illustrate the example shown.", "DESCRIPTION Inkjet printers that utilize a substrate wide print bar assembly have been developed to help increase printing speeds and reduce printing costs.", "Conventional substrate wide print bar assemblies include multiple parts that carry printing fluid from the printing fluid supplies to the small printhead dies from which the printing fluid is ejected on to the paper or other print substrate.", "While reducing the size and spacing of the printhead dies continues to be important for reducing cost, channeling printing fluid from the larger supply components to ever smaller, more tightly spaced dies requires complex flow structures and fabrication processes that can actually increase cost.", "A new fluid flow structure has been developed to enable the use of smaller printhead dies and more compact die circuitry to help reduce cost in substrate wide inkjet printers.", "A print bar implementing one example of the new structure includes multiple printhead dies molded into an elongated, monolithic body of moldable material.", "Printing fluid channels molded into the body carry printing fluid directly to printing fluid flow passages in each die.", "The molding in effect grows the size of each die for making external fluid connections and for attaching the dies to other structures, thus enabling the use of smaller dies.", "The printhead dies and printing fluid channels can be molded at the wafer level to form a new, composite printhead wafer with built-in printing fluid channels, eliminating the need to form the printing fluid channels in a silicon substrate and enabling the use of thinner dies.", "The new fluid flow structure is not limited to print bars or other types of printhead structures for inkjet printing, but may be implemented in other devices and for other fluid flow applications.", "Thus, in one example, the new structure includes a micro device embedded in a molding having a channel or other path for fluid to flow directly into or onto the device.", "The micro device, for example, could be an electronic device, a mechanical device, or a microelectromechanical system (MEMS) device.", "The fluid flow, for example, could be a cooling fluid flow into or onto the micro device or fluid flow into a printhead die or other fluid dispensing micro device.", "These and other examples shown in the figures and described below illustrate but do not limit the invention, which is defined in the Claims following this Description.", "As used in this document, a “micro device” means a device having one or more exterior dimensions less than or equal to 30 mm; “thin” means a thickness less than or equal to 650 μm; a “sliver” means a thin micro device having a ratio of length to width (L/W) of at least three; a “printhead” and a “printhead die” mean that part of an inkjet printer or other inkjet type dispenser that dispenses fluid from one or more openings.", "A printhead includes one or more printhead dies, “printhead” and “printhead die” are not limited to printing with ink and other printing fluids but also include inkjet type dispensing of other fluids and/or for uses other than printing.", "FIGS.", "1 and 2 are elevation and plan section views, respectively, illustrating one example a new fluid flow structure 10.Referring to FIGS.", "1 and 2, structure 10 includes a micro device 12 molded into in a monolithic body 14 of plastic or other moldable material.", "A molded body 14 is also referred to herein as a molding 14.Micro device 12, for example, could be an electronic device, a mechanical device, or a microelectromechanical system (MEMS) device.", "A channel or other suitable fluid flow path 16 is molded into body 14 in contact with micro device 12 so that fluid in channel 16 can flow directly into or onto device 12 (or both).", "In this example, channel 16 is connected to fluid flow passages 18 in micro device 12 and exposed to exterior surface 20 of micro device 12.In another example, shown in FIGS.", "3 and 4, flow path 16 in molding 14 allows air or other fluid to flow along an exterior surface 20 of micro device 12, for instance to cool device 12.Also, in this example, signal traces or other conductors 22 connected to device 12 at electrical terminals 24 are molded into molding 14.In another example, shown in FIGS.", "5 and 6, micro device 12 is molded into body 14 with an exposed surface 26 opposite channel 16.In another example, shown in FIGS.", "7 and 8, micro devices 12A and 12B are molded into body 14 with fluid flow channels 16A and 16B.", "In this example, flow channels 16A contact the edges of outboard devices 12A while flow channel 16B contacts the bottom of inboard device 12B.", "FIG.", "9 is a block diagram illustrating a system 28 implementing a new fluid flow structure 10 such as one of the flow structures 10 shown in FIGS.", "1-8.Referring to FIG.", "9, system 28 includes a fluid source 30 operatively connected to a fluid mover 32 configured to move fluid to flow path 16 in structure 10.A fluid source 30 might include, for example, the atmosphere as a source of air to cool an electronic micro device 12 or a printing fluid supply for a printhead micro device 12.Fluid mover 32 represents a pump, a fan, gravity or any other suitable mechanism for moving fluid from source 30 to flow structure 10.FIG.", "10 is a block diagram illustrating an inkjet printer 34 implementing one example of a new fluid flow structure 10 in a substrate wide print bar 36.Referring to FIG.", "10, printer 34 includes print bar 36 spanning the width of a print substrate 38, flow regulators 40 associated with print bar 36, a substrate transport mechanism 42, ink or other printing fluid supplies 44, and a printer controller 46.Controller 46 represents the programming, processor(s) and associated memories, and the electronic circuitry and components needed to control the operative elements of a printer 10.Print bar 36 includes an arrangement of printheads 37 for dispensing printing fluid on to a sheet or continuous web of paper or other print substrate 38.As described in detail below, each printhead 37 includes one or more printhead dies in a molding with channels 16 to feed printing fluid directly to the die(s).", "Each printhead die receives printing fluid through a flow path from supplies 44 into and through flow regulators 40 and channels 16 in print bar 36.FIGS.", "11-16 illustrate an inkjet print bar 36 implementing one example of a new fluid flow structure 10, such as might be used in printer 34 shown in FIG.", "10.Referring first to the plan view of FIG.", "11, printheads 37 are embedded in an elongated, monolithic molding 14 and arranged generally end to end in rows 48 in a staggered configuration in which the printheads in each row overlap another printhead in that row.", "Although four rows 48 of staggered printheads 37 are shown, for printing four different colors for example, other suitable configurations are possible.", "FIG.", "12 is a section view taken along the line 12-12 in FIG.", "11.FIGS.", "13-15 are detail views from FIG.", "12, and FIG.", "16 is a plan view diagram showing the layout of some of the features of printhead die flow structure 10 in FIGS.", "12-14.Referring now to FIGS.", "11-15, in the example shown, each printhead 37 includes a pair of printhead dies 12 each with two rows of ejection chambers 50 and corresponding orifices 52 through which printing fluid is ejected from chambers 50.Each channel 16 in molding 14 supplies printing fluid to one printhead die 12.Other suitable configurations for printhead 37 are possible.", "For example, more or fewer printhead dies 12 may be used with more or fewer ejection chambers 50 and channels 16.", "(Although print bar 36 and printheads 37 face up in FIGS.", "12-15, print bar 36 and printheads 37 usually face down when installed in a printer, as depicted in the block diagram of FIG.", "10.)", "Printing fluid flows into each ejection chamber 50 from a manifold 54 extending lengthwise along each die 12 between the two rows of ejection chambers 50.Printing fluid feeds into manifold 54 through multiple ports 56 that are connected to a printing fluid supply channel 16 at die surface 20.Printing fluid supply channel 16 is substantially wider than printing fluid ports 56, as shown, to carry printing fluid from larger, loosely spaced passages in the flow regulator or other parts that carry printing fluid into print bar 36 to the smaller, tightly spaced printing fluid ports 56 in printhead die 12.Thus, printing fluid supply channels 16 can help reduce or even eliminate the need for a discrete “fan-out” and other fluid routing structures necessary in some conventional printheads.", "In addition, exposing a substantial area of printhead die surface 20 directly to channel 16, as shown, allows printing fluid in channel 16 to help cool die 12 during printing.", "The idealized representation of a printhead die 12 in FIGS.", "11-15 depicts three layers 58, 60, 62 for convenience only to clearly show ejection chambers 50, orifices 52, manifold 54, and ports 56.An actual inkjet printhead die 12 is a typically complex integrated circuit (IC) structure formed on a silicon substrate 58 with layers and elements not shown in FIGS.", "11-15.For example, a thermal ejector element or a piezoelectric ejector element formed on substrate 58 at each ejection chamber 50 is actuated to eject drops or streams of ink or other printing fluid from orifices 52.A molded flow structure 10 enables the use of long, narrow and very thin printhead dies 12.For example, it has been shown that a 100 μm thick printhead die 12 that is about 26 mm long and 500 μm wide can be molded into a 500 μm thick body 14 to replace a conventional 500 μm thick silicon printhead die.", "Not only is it cheaper and easier to mold channels 16 into body 14 compared to forming the feed channels in a silicon substrate, but it is also cheaper and easier to form printing fluid ports 56 in a thinner die 12.For example, ports 56 in a 100 μm thick printhead die 12 may be formed by dry etching and other suitable micromachining techniques not practical for thicker substrates.", "Micromachining a high density array of straight or slightly tapered through ports 56 in a thin silicon, glass or other substrate 58 rather than forming conventional slots leaves a stronger substrate while still providing adequate printing fluid flow.", "Tapered ports 56 help move air bubbles away from manifold 54 and ejection chambers 50 formed, for example, in a monolithic or multi-layered orifice plate 60/62 applied to substrate 58.It is expected that current die handling equipment and micro device molding tools and techniques can be adapted to mold dies 12 as thin as 50 μm, with a length/width ratio up to 150, and to mold channels 16 as narrow as 30 μm.", "And, the molding 14 provides an effective but inexpensive structure in which multiple rows of such die slivers can be supported in a single, monolithic body.", "FIGS.", "17-21 illustrate one example process for making a new printhead fluid flow structure 10.FIG.", "22 is a flow diagram of the process illustrated in FIGS.", "17-21.Referring first to FIG.", "17, a flex circuit 64 with conductive traces 22 and protective layer 66 is laminated on to a carrier 68 with a thermal release tape 70, or otherwise applied to carrier 68 (step 102 in FIG.", "22).", "As shown in FIGS.", "18 and 19, printhead die 12 is placed orifice side down in opening 72 on carrier 68 (step 104 in FIG.", "22) and conductor 22 is bonded to an electrical terminal 24 on die 12 (step 106 in FIG.", "22).", "In FIG.", "20, a molding tool 74 forms channel 16 in a molding 14 around printhead die 12 (step 108 in FIG.", "22).", "A tapered channel 16 may be desirable in some applications to facilitate the release of molding tool 74 or to increase fan-out (or both).", "After molding, printhead flow structure 10 is released from carrier 68 (step 110 in FIG.", "22) to form the completed part shown in FIG.", "21 in which conductor 22 is covered by layer 66 and surrounded by molding 14.In a transfer molding process such as that shown in FIG.", "20, channels 16 are molded into body 14.In other fabrication processes, it may be desirable to form channels 16 after molding body 14 around printhead die 12.While the molding of a single printhead die 12 and channel 16 is shown in FIGS.", "17-21, multiple printhead dies and printing fluid channels can be molded simultaneously at the wafer level.", "FIGS.", "23-28 illustrate one example wafer level process for making print bars 36.Referring to FIG.", "23, printheads 37 are placed on a glass or other suitable carrier wafer 68 in a pattern of multiple print bars.", "(Although a “wafer” is sometimes used to denote a round substrate while a “panel” is used to denote a rectangular substrate, a “wafer” as used in this document includes any shape substrate.)", "Printheads 37 usually will be placed on to carrier 68 after first applying or forming a pattern of conductors 22 and die openings 72 as described above with reference to FIG.", "17 and step 102 in FIG.", "22.In the example shown in FIG.", "23, five sets of dies 78 each having four rows of printheads 37 are laid out on carrier wafer 66 to form five print bars.", "A substrate wide print bar for printing on Letter or A4 size substrates with four rows of printheads 37, for example, is about 230 mm long and 16 mm wide.", "Thus, five die sets 78 may be laid out on a single 270 mm×90 mm carrier wafer 66 as shown in FIG.", "23.Again, in the example shown, an array of conductors 22 extend to bond pads 23 near the edge of each row of printheads 37.Conductors 22 and bond pads 23 are more clearly visible in the detail of FIG.", "28.", "(Conductive signal traces to individual ejection chambers or groups of ejection chambers, such as conductors 22 in FIG.", "21, are omitted to not obscure other structural features.)", "FIG.", "24 is a close-up section view of one set of four rows of printheads 37 taken along the line 24-24 in FIG.", "23.Cross hatching is omitted for clarity.", "FIGS.", "23 and 24 show the in-process wafer structure after the completion of steps 102-112 in FIG.", "23.FIG.", "25 shows the section of FIG.", "24 after molding step 114 in FIG.", "23 in which body 14 with channels 16 is molded around printhead dies 12.Individual print bar strips 78 are separated in FIG.", "26 and released from carrier 68 in FIG.", "27 to form five individual print bars 36 (step 116 in FIG.", "23).", "While any suitable molding technology may be used, testing suggests that wafer level molding tools and techniques currently used for semiconductor device packaging may be adapted cost effectively to the fabrication of printhead die fluid flow structures 10 such as those shown in FIGS.", "21 and 27.A stiffer molding 14 may be used where a rigid (or at least less flexible) print bar 36 is desired to hold printhead dies 12.A less stiff molding 14 may be used where a flexible print bar 36 is desired, for example where another support structure holds the print bar rigidly in a single plane or where a non-planar print bar configuration is desired.", "Also, although it is expected that molded body 14 usually will be molded as a monolithic part, body 14 could be molded as more than one part.", "FIGS.", "29-31 illustrate other examples of a new fluid flow structure 10 for a printhead die 12.In these examples, channels 16 are molded in body 14 along each side of printhead die 12, for example using a transfer molding process such as that described above with reference to FIGS.", "17-21.Printing fluid flows from channels 16 through ports 56 laterally into each ejection chamber 50 directly from channels 16.In the example of FIG.", "30, orifice plate 62 is applied after molding body 14 to close channels 16.In the example of FIG.", "31, a cover 80 is formed over orifice plate 62 to close channels 16.Although a discrete cover 80 partially defining channels 16 is shown, an integrated cover 80 molded into body 14 could also be used.", "As noted at the beginning of this Description, the examples shown in the figures and described above illustrate but do not limit the invention.", "Other examples are possible.", "Therefore, the foregoing description should not be construed to limit the scope of the invention, which is defined in the following claims." ] ]
Patent_15872713
[ [ "EDDY CURRENT ARRAY PROBE AND METHOD FOR LIFT-OFF COMPENSATION DURING OPERATION WITHOUT KNOWN LIFT REFERENCES", "The invention provides a method for compensating the sensitivity variations induced by lift-off variations for an eddy current array probe.", "The invention uses the eddy current array probe coils in two separate ways to produce a first set of detection channels and a second set of lift-off measurement channels without the need to add coils dedicated to the lift-off measurement operation.", "Another aspect of the invention provides an improved calibration process which combines the detection and lift-off measurement channel calibration on a simple calibration block including a reference defect without the need of a pre-defined lift-off condition." ], [ "1.An EC (Eddy Current) system for detecting flaws in a test object, the system comprising: (a) an EC array probe configured with a sensor arrangement including: (i) a plurality of first type EC sensors arranged in channels and configured to induce eddy currents in the test object and to sense and output first signals representative of flaws in the test object; (ii) a plurality of second type EC sensors configured to produce from the test object second signals indicative of a lift-off distance of said orthogonal and absolute EC sensors relative to said test object, said EC coil arrangement being configured so that a pre-determined ratio is established between said second signals and said first signals, at different lift-off distances; (b) a setup table comprising calibration values for said orthogonal EC sensors with corresponding lift-off compensation values for said channels based on said second signals; and (c) an acquisition unit responsive to said calibration and lift-off compensation values in said setup table and to said second signals and configured to convert said first signals obtained from said orthogonal EC sensors during actual testing of said test object, so as to obtain third signals which are representative of said flows in said test object, said third signals being substantially independent of actual lift-off distances prevailing between said EC sensors and said test object at the time of obtaining said first signals doing said actual testing.", "2.The system of claim 1, wherein the EC array probe is provided on a printed circuit board.", "3.The system of claim 1, wherein said EC array probe comprises overlapping coils configured as driver and receiver coils.", "4.The system of claim 2, wherein said plurality of first type EC sensors are configured to generate a first set of orthogonal channels that extend along a first line.", "5.The system of claim 4, wherein said plurality of second type EC sensors are arranged so that absolute channels are arranged along at least one line, that extends parallel to said first line.", "6.The system of claim 5, wherein at least one pair of said absolute channels physically sandwich said orthogonal channels.", "7.The system of claim 6, wherein an average of two absolute, channel sensitive areas are used to obtain a lift-off value for a corresponding orthogonal channel.", "8.The system of claim 1, wherein said absolute channels are located not to be in line with longitudinal or transversal test object cracks when said cracks are located on a sensitive area of an orthogonal channel.", "9.The system of claim 1, wherein said acquisition unit is effective to drive the first type and second type channel sensors simultaneously.", "10.The system of claim 1, wherein corresponding first type and second type channels use same sets of drive coils to enable faster acquisition and more stable signals.", "11.The system of claim 3, wherein said driver coils are connected as part of an impedance bridge to realize the absolute channels.", "12.The system of claim 1, wherein said first type sensors are orthogonal sensors and said second type sensors are absolute sensors.", "13.The system of claim 1, wherein said system is configured as a differential Eddy Current array probe.", "14.The system of claim 12, wherein said absolute EC sensors are formed of physical coils which also form said orthogonal EC sensors.", "15.The system of claim 2, wherein said probes are arranged in at least four layers on said circuit board.", "16.The system of claim 2, wherein said EC array probe comprises GMR sensors.", "17.The system of claim 2, wherein said EC array probe comprises AMR sensors.", "18.The system of claim 2, wherein said EC array probe comprises Hall Effect sensors.", "19.A method for testing an object using an EC (Eddy Current) system, the method comprising the steps of: providing an EC array probe including: (i) a plurality of first type EC sensors arranged in a plurality of channels and configured to induce eddy currents in a test object and to output first signals representative of flaws in the test object; and (ii) a plurality of second type EC sensors arranged in channels and configured to produce from the test object second signals indicative of a lift-off distance of said first type and second type EC sensors relative to said test object, said EC coil arrangement being configured so that a substantially constant ratio is established between said second signals and said first signals, at different lift-off distances; performing a probe array system setup including storing at least a gain value on each orthogonal channel relative to a known calibration notch using the first type EC sensors; obtaining relative to each orthogonal channel an amplitude vector value by using said second type EC sensors; and storing said gain and amplitude vector values in a setup table.", "20.The method of claim 19, further including performing a data acquisition procedure comprising: acquiring actual Eddy Current data for said first type channels and second type channels relative to said object, said data including raw orthogonal data and raw absolute data for each channel; calculating amplitude vector lengths; and compensating said raw orthogonal data for lift-off effects utilizing said absolute vector lengths and applying said calibration gain values to obtain third signal which are representative of flaws in said object and independent of said lift off distances.", "21.The method of claim 20, wherein said system setup step includes setting a phase rotation value and a gain value at each orthogonal channel and calculating both gain and phase values at each position.", "22.The method of claim 20, including acquiring said orthogonal and absolute data simultaneously during actual testing of said test object.", "23.The method of claim 20, including driving said orthogonal and absolute EC sensor simultaneously.", "24.The method of claim 20, wherein said amplitude vector values are between air and a calibration base line." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Eddy current inspection is commonly used to non-destructively detect flaws in surfaces of manufactured components fabricated from a conductive material, such as bars, tubes, and special parts for automotive, aeronautic or energy industries.", "Over the years, eddy current sensors have been designed with different configurations and shapes.", "Typical eddy current sensor configurations include impedance bridge, pitch-catch (alternatively called reflection or transmit-receive) and differential configurations, but can also include more complex combinations such as pitch-catch with differential receivers, multi-differential, etc.", "An even greater variety of probe shapes has been developed over the years, with a few of them being truly successful configurations, as known in the industry.", "One such known first type of eddy current sensor, named orthogonal, cross-wound or plus point, is mounted on a cube or a cross-shaped core, with two coils wrapped orthogonally to each other.", "One of the coils is the driver and is wrapped perpendicularly to the other coil core axis, used as the receiver.", "On this particular orthogonal sensor, the driver and the receiver coils are positioned perpendicularly to the component to inspect.", "This feature decouples the driver magnetic field from the sensitive axis of the receiver, thereby reducing the sensitivity of the receiver to surface noise that does not represent a flaw.", "With the advances of printed circuit board (PCB) technologies over the last decades, it is now possible to manufacture some eddy current sensor shapes and configurations on a thin flexible support.", "Even more interesting is the use of these manufacturing technologies to manufacture eddy current array probes, since the reduced cost, flexibility and reproducibility are critical factors for a successful array probe design.", "The present assignee's pending U.S. patent application Ser.", "No.", "12/832,620 describes how to build an orthogonal probe with the printed circuit board technology.", "The contents of said Ser.", "No.", "12/832,620 application are incorporated by reference herein.", "Many eddy current sensors generate a very strong signal representative of variations in the distance (lift-off) between the sensor and inspected part.", "Such sensors referred to herein as being of a second type are commonly referred to as having an “absolute” response because they provide relatively direct information of the coupling between the sensor and the inspected component.", "On the other hand, a few configurations (including the orthogonal and some differential arrangements) only exhibit a reduction in sensitiveness with increasing lift-off.", "Such configurations are then ideal to conduct an inspection over irregular parts (such as welds or hot rolled bars) or when the inspection environment cannot provide a perfectly stable lift-off.", "Still, even for orthogonal and differential sensors, the potential sensitivity variations related to corresponding lift-off variations are an important limiting factor for the detection capabilities of eddy current sensors.", "This problem is even more important for eddy current array probes which include several independent eddy current channels because it is easier to maintain a constant lift-off for a single sensor than for a sensor array.", "Various terms used herein have the following definitions: (i) An eddy current sensor is a complete coil arrangement capable of generating eddy currents in the test part and receiving the magnetic field produced by those eddy currents; (ii) An Eddy Current Array (ECA) probe is a complete assembly including several sensors; and (iii) An Eddy Current Array (ECA) channel is a unique combination of sensor and test conditions (frequency, gain, etc), such that a thirty two sensor ECA probe driven with two test frequencies would generate, for example, sixty four channels.", "U.S. Pat.", "No.", "5,371,461 discloses a means for compensating the lift-off for an ECA probe made out of etched coils by combining differential sensors for defect detection and pitch-catch sensors for lift-off measurement in the same probe.", "In this patent, the added pitch-catch sensors require additional coils to be etched in the probe, which adds to the probe complexity and size.", "The contents of U.S. Pat.", "No.", "5,371,461 are incorporated by reference herein.", "The method presented in U.S. Pat.", "No.", "5,371,461 also requires the use of a precise lift-off reference to calibrate the lift-off measurement channels.", "Such a reference may be very difficult to obtain for complex and/or irregular shaped parts.", "This lift-off reference also adds to the complexity of the solution regarding its day to day usage because of the additional calibration steps and the precision level involved.", "Other methods found in the prior art (for example, in U.S. publication 200300716 or U.S. Pat.", "No.", "4,727,322) include the use of a pre-defined impedance plane relative to a set of measured variables, including lift-off.", "These methods require intensive calculation and/or experimental data to achieve results on very limited set of probe and part configurations.", "Accordingly, it is an object of the disclosure to provide a means for compensating the lift-off sensitivity variations for either a differential or orthogonal eddy current probe array without the use of additional coils.", "It is also an object of the disclosure to provide a means for compensating the lift off without the need to calibrate the probe on a fixed lift-off reference.", "It is a further object of the disclosure to have a means for compensating the lift-off without the need for pre-generated tables specific to an application or probe.", "A still further object of the disclosure is to reduce the number of interconnections in the probe, thus allowing a more compact probe design.", "Yet another object of the disclosure is to enable conducting the lift-off compensation calibration and detection channel calibration simultaneously.", "Still another object of the disclosure is to eliminate the need for pre-calculated lift-off tables which are typically dependent on the inspected material and sensor characteristics (test frequency, sensor size, etc)." ], [ "<SOH> SUMMARY OF THE DISCLOSURE <EOH>The invention provides a method for compensating the sensitivity variations induced by corresponding lift-off variations for an eddy current array probe.", "The invention uses the eddy current array probe coils in two separate ways to produce a first set of detection channels and a second set of lift-off measurement channels without the need to add coils dedicated to the lift-off measurement operation.", "Another aspect of the invention provides an improved calibration process which combines the detection and lift-off measurement channel calibration on a simple calibration block including a reference defect without the need of a pre-defined lift-off condition.", "In a preferred embodiment of the invention, an EC probe array system for detecting flaws in a test object is provided.", "That system includes: (a) an EC coil arrangement including: (i) a plurality of orthogonal EC sensors arranged in channels and configured to induce eddy currents in the test object and to sense and output first signals representative of flaws in the test object; (ii) a plurality of absolute EC sensors configured to produce from the test object second signals indicative of a lift-off distance of said orthogonal and absolute EC sensors relative to said test object, said EC coil arrangement being configured so that a pre-determined or given ratio is established between said second signals and said first signals, at different lift-off distances; (b) a setup table comprising calibration values for said orthogonal EC sensors with corresponding lift-off compensation values for each of said channels based on said second signals; and (c) a processor or acquisition unit responsive to said calibration and lift-off compensation values in said setup table and to the second signals and configured to convert said first signals obtained from said orthogonal EC sensors during actual testing of said test object, so as to obtain third signals which are representative of said Eddy Currents in said test object, said third signals being substantially independent of actual lift-off distances prevailing between said EC sensors and said test object at the time of obtaining said first signals during actual testing.", "In further preferred embodiments, the EC coil arrangement is provided on a printed circuit board.", "The EC coil arrangement may comprise coils configured as overlapped coils and configured as driver and receiver coils.", "The processor may drive the orthogonal absolute channels sensors simultaneously and with a pitch-catch type configuration.", "Also, orthogonal and absolute channels may use the same sets of drive coils to enable faster acquisition and more stable signals.", "In the method according to the present disclosure, the aforementioned EC coil arrangement is utilized to perform a probe array system setup including setting at least a gain value and preferably a phase rotation value on each orthogonal channel relative to a known calibration notch using the orthogonal EC sensors.", "Relative to each orthogonal channel, an amplitude vector is also obtained by using the absolute EC sensors and gain and absolute vector length values are stored in a setup table.", "Subsequent to preparing the setup table, actual testing is conducted by acquiring data for the orthogonal and absolute channels to obtain raw orthogonal data and raw absolute data for each channel.", "Amplitude vector lengths are calculated and the raw orthogonal data is compensated for the lift-off effects utilizing the absolute vector lengths and/or calibration gain values to obtain compensated data for the object being tested.", "Other features and advantages of the present invention will become apparent from the following description of the invention which refers to the accompanying drawings." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application claims the benefit and priority of U.S. Non-Provisional patent application Ser.", "No.", "13/427205 filed Mar.", "22, 2012 entitled AN EDDY CURRENT ARRAY PROBE AND METHOD FOR LIFT-OFF COMPENSATION DURING OPERATION WITHOUT KNOWN LIFT REFERENCES, the entire disclosures of which are incorporated herein by reference.", "FIELD OF THE INVENTION The present invention relates to non-destructive testing and inspection systems (NDT/NDI), and more particularly to Eddy Current Array technology (ECA), eddy current probes etched on printed circuit board and lift-off compensation.", "BACKGROUND OF THE INVENTION Eddy current inspection is commonly used to non-destructively detect flaws in surfaces of manufactured components fabricated from a conductive material, such as bars, tubes, and special parts for automotive, aeronautic or energy industries.", "Over the years, eddy current sensors have been designed with different configurations and shapes.", "Typical eddy current sensor configurations include impedance bridge, pitch-catch (alternatively called reflection or transmit-receive) and differential configurations, but can also include more complex combinations such as pitch-catch with differential receivers, multi-differential, etc.", "An even greater variety of probe shapes has been developed over the years, with a few of them being truly successful configurations, as known in the industry.", "One such known first type of eddy current sensor, named orthogonal, cross-wound or plus point, is mounted on a cube or a cross-shaped core, with two coils wrapped orthogonally to each other.", "One of the coils is the driver and is wrapped perpendicularly to the other coil core axis, used as the receiver.", "On this particular orthogonal sensor, the driver and the receiver coils are positioned perpendicularly to the component to inspect.", "This feature decouples the driver magnetic field from the sensitive axis of the receiver, thereby reducing the sensitivity of the receiver to surface noise that does not represent a flaw.", "With the advances of printed circuit board (PCB) technologies over the last decades, it is now possible to manufacture some eddy current sensor shapes and configurations on a thin flexible support.", "Even more interesting is the use of these manufacturing technologies to manufacture eddy current array probes, since the reduced cost, flexibility and reproducibility are critical factors for a successful array probe design.", "The present assignee's pending U.S. patent application Ser.", "No.", "12/832,620 describes how to build an orthogonal probe with the printed circuit board technology.", "The contents of said Ser.", "No.", "12/832,620 application are incorporated by reference herein.", "Many eddy current sensors generate a very strong signal representative of variations in the distance (lift-off) between the sensor and inspected part.", "Such sensors referred to herein as being of a second type are commonly referred to as having an “absolute” response because they provide relatively direct information of the coupling between the sensor and the inspected component.", "On the other hand, a few configurations (including the orthogonal and some differential arrangements) only exhibit a reduction in sensitiveness with increasing lift-off.", "Such configurations are then ideal to conduct an inspection over irregular parts (such as welds or hot rolled bars) or when the inspection environment cannot provide a perfectly stable lift-off.", "Still, even for orthogonal and differential sensors, the potential sensitivity variations related to corresponding lift-off variations are an important limiting factor for the detection capabilities of eddy current sensors.", "This problem is even more important for eddy current array probes which include several independent eddy current channels because it is easier to maintain a constant lift-off for a single sensor than for a sensor array.", "Various terms used herein have the following definitions: (i) An eddy current sensor is a complete coil arrangement capable of generating eddy currents in the test part and receiving the magnetic field produced by those eddy currents; (ii) An Eddy Current Array (ECA) probe is a complete assembly including several sensors; and (iii) An Eddy Current Array (ECA) channel is a unique combination of sensor and test conditions (frequency, gain, etc), such that a thirty two sensor ECA probe driven with two test frequencies would generate, for example, sixty four channels.", "U.S. Pat.", "No.", "5,371,461 discloses a means for compensating the lift-off for an ECA probe made out of etched coils by combining differential sensors for defect detection and pitch-catch sensors for lift-off measurement in the same probe.", "In this patent, the added pitch-catch sensors require additional coils to be etched in the probe, which adds to the probe complexity and size.", "The contents of U.S. Pat.", "No.", "5,371,461 are incorporated by reference herein.", "The method presented in U.S. Pat.", "No.", "5,371,461 also requires the use of a precise lift-off reference to calibrate the lift-off measurement channels.", "Such a reference may be very difficult to obtain for complex and/or irregular shaped parts.", "This lift-off reference also adds to the complexity of the solution regarding its day to day usage because of the additional calibration steps and the precision level involved.", "Other methods found in the prior art (for example, in U.S. publication 200300716 or U.S. Pat.", "No.", "4,727,322) include the use of a pre-defined impedance plane relative to a set of measured variables, including lift-off.", "These methods require intensive calculation and/or experimental data to achieve results on very limited set of probe and part configurations.", "Accordingly, it is an object of the disclosure to provide a means for compensating the lift-off sensitivity variations for either a differential or orthogonal eddy current probe array without the use of additional coils.", "It is also an object of the disclosure to provide a means for compensating the lift off without the need to calibrate the probe on a fixed lift-off reference.", "It is a further object of the disclosure to have a means for compensating the lift-off without the need for pre-generated tables specific to an application or probe.", "A still further object of the disclosure is to reduce the number of interconnections in the probe, thus allowing a more compact probe design.", "Yet another object of the disclosure is to enable conducting the lift-off compensation calibration and detection channel calibration simultaneously.", "Still another object of the disclosure is to eliminate the need for pre-calculated lift-off tables which are typically dependent on the inspected material and sensor characteristics (test frequency, sensor size, etc).", "SUMMARY OF THE DISCLOSURE The invention provides a method for compensating the sensitivity variations induced by corresponding lift-off variations for an eddy current array probe.", "The invention uses the eddy current array probe coils in two separate ways to produce a first set of detection channels and a second set of lift-off measurement channels without the need to add coils dedicated to the lift-off measurement operation.", "Another aspect of the invention provides an improved calibration process which combines the detection and lift-off measurement channel calibration on a simple calibration block including a reference defect without the need of a pre-defined lift-off condition.", "In a preferred embodiment of the invention, an EC probe array system for detecting flaws in a test object is provided.", "That system includes: (a) an EC coil arrangement including: (i) a plurality of orthogonal EC sensors arranged in channels and configured to induce eddy currents in the test object and to sense and output first signals representative of flaws in the test object; (ii) a plurality of absolute EC sensors configured to produce from the test object second signals indicative of a lift-off distance of said orthogonal and absolute EC sensors relative to said test object, said EC coil arrangement being configured so that a pre-determined or given ratio is established between said second signals and said first signals, at different lift-off distances; (b) a setup table comprising calibration values for said orthogonal EC sensors with corresponding lift-off compensation values for each of said channels based on said second signals; and (c) a processor or acquisition unit responsive to said calibration and lift-off compensation values in said setup table and to the second signals and configured to convert said first signals obtained from said orthogonal EC sensors during actual testing of said test object, so as to obtain third signals which are representative of said Eddy Currents in said test object, said third signals being substantially independent of actual lift-off distances prevailing between said EC sensors and said test object at the time of obtaining said first signals during actual testing.", "In further preferred embodiments, the EC coil arrangement is provided on a printed circuit board.", "The EC coil arrangement may comprise coils configured as overlapped coils and configured as driver and receiver coils.", "The processor may drive the orthogonal absolute channels sensors simultaneously and with a pitch-catch type configuration.", "Also, orthogonal and absolute channels may use the same sets of drive coils to enable faster acquisition and more stable signals.", "In the method according to the present disclosure, the aforementioned EC coil arrangement is utilized to perform a probe array system setup including setting at least a gain value and preferably a phase rotation value on each orthogonal channel relative to a known calibration notch using the orthogonal EC sensors.", "Relative to each orthogonal channel, an amplitude vector is also obtained by using the absolute EC sensors and gain and absolute vector length values are stored in a setup table.", "Subsequent to preparing the setup table, actual testing is conducted by acquiring data for the orthogonal and absolute channels to obtain raw orthogonal data and raw absolute data for each channel.", "Amplitude vector lengths are calculated and the raw orthogonal data is compensated for the lift-off effects utilizing the absolute vector lengths and/or calibration gain values to obtain compensated data for the object being tested.", "Other features and advantages of the present invention will become apparent from the following description of the invention which refers to the accompanying drawings.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates a simplified representation of the prior art flat shaped orthogonal eddy current array probe built on a two layer printed circuit board FIG.", "2 is the four layer printed circuit board extension of the FIG.", "1 representation and the illustration of the possible shape of the orthogonal channels FIG.", "3 illustrates the absolute channels created for the probe structure of FIG.", "2 FIG.", "4 shows that cracks affecting the orthogonal channels will not affect the corresponding absolute channel.", "FIG.", "5 shows the absolute and orthogonal sensitive area on the four layer probe of FIG.", "2.FIG.", "6 illustrates the scan of a calibration block including a reference notch and a probe lift-off.", "FIG.", "7 is the impedance plane results obtain on the orthogonal channels from the scan of FIG.", "6 block with four defined lift off condition.", "FIG.", "8 is the impedance plane results obtain on the absolute channels from the scan of FIG.", "6 block with four defined lift off condition.", "FIG.", "9 proposes an amplitude based analysis of the test signals shown on FIG.", "7 and FIG.", "8.FIG.", "10 is a flowchart describing the proposed calibration method.", "FIG.", "11 is a flowchart describing the proposed signal processing method.", "FIG.", "12 shows a hardware configuration for a system of the invention.", "DETAILED DESCRIPTION OF THE INVENTION Related patent application Ser.", "No.", "12/832,620 describes how to build an ECA probe on a printed circuit board.", "The contents of patent application Ser.", "Nos.", "12/832,620 and of 12/847,074 are incorporated by reference herein.", "The structure presented in application Ser.", "No.", "12/832,620 is disposed on two PCB layers.", "A simplified representation of such structure is shown on FIG.", "1 for a four sensor orthogonal ECA probe 1 including five driver coils (2a to 2e) and five receiver coils (3a to 3e) resulting in four sensitive spots (4a to 4d) with orthogonal sensor response.", "The coil arrangement (such as 5 and 6) that generates orthogonal sensor response will be referenced to as “orthogonal channels” in this document.", "As first stated in paragraph [0035] of the mentioned application, it is also possible to use the multi-layer capabilities of the printed circuit boards to increase the resolution of the orthogonal ECA probe.", "FIG.", "2 illustrates a four layer version of the ECA probe 10 built using this principle.", "The two bottom layers (11a to 11e and 12a to 12e) are connected to driver signals while the two upper layers (13a to 13e and 14a to 14e) are connected to receiver signals in order to generate orthogonal channels such as 16, 17, 18 and 19.The bottom layer coils 11a to 11e operate with the top layer coils 14a to 14e to generate a first set of orthogonal channels while coils 12a to 12e operate with the coils 13a to 13e to generate a second set of orthogonal channels.", "From the probe structure shown on FIG.", "2, it is an object of the current invention to teach how to obtain absolute channels for monitoring the lift-off.", "FIG.", "3 illustrates how these channels are built from the structure of probe 10.Some coils, partially overlapping the driver coils, are connected as receivers.", "For example, pitch-catch sensor configuration 36 uses two fourth layer coils (11b and 11c) as a driver and one second layer coil (13d) as receiver.", "In another example, pitch-catch configuration 33 uses two third layer coils (12b and 12c) as a driver and one fourth layer coil (11c) as a receiver.", "As a matter of fact, the same coil can be used as a driver and a receiver through the sequence (as already disclosed in prior art Pat.", "No.", "6,344,739).", "Using coil combinations similar to 31, 32, 33, 34, 35 and 36 for the whole probe 10, we obtain a set of nine sensitive areas (30a to 30i) with absolute sensor response extending over the whole probe length.", "The coil arrangements (such as 31 to 36) that generate absolute sensor response will be referred to herein as “absolute channels” in this disclosure.", "The newly created absolute channels are inherently very sensitive to lift off, because the proximity of the inspected part will directly impact the magnetic field flux in the shared area of the driver and receiver coils (11c and 13d for example) defining the sensitive area (30f for example) of the absolute channel (36 for example).", "FIG.", "4 also demonstrates that the new absolute channel will not be sensitive to a longitudinal 41 or transversal 40 crack to be detected by the orthogonal channel because the absolute channel sensitive area (30f for example) is not in line with longitudinal or transverse crack when this crack is located on the orthogonal channel sensitive area (15d for example).", "So, the described structure makes it possible to substantially completely decouple the lift-off and crack measurements for this probe.", "As further demonstrated on FIG.", "5, each orthogonal channel sensitive area is located exactly in between two absolute channels sensitive areas on the index axis.", "So, we can use the average value between these two absolute channels to produce an approximation of the lift-off conditions for the corresponding orthogonal channel.", "It must be understood that the selection of coils to be used in the absolute channel construction was made in order to acquire the orthogonal and absolute channels simultaneously and with a pitch-catch type configuration which is naturally more stable than an impedance bridge.", "For example, orthogonal channel 16 and absolute channel 36 use the same set of two driver coils 11b and 11c.", "So, these two channels can be acquired simultaneously by the acquisition electronics.", "This configuration is advantageous because it allows a faster acquisition (through simultaneous operation) and a stable signal, but it is not a mandatory requirement so there will be other possible arrangements respecting the essence of the invention.", "Connecting the driver coils as part of an impedance bridge to build the absolute channels, for example, is another method to obtain a valid set of absolute channels for lift-off monitoring without adding new coils in the probe structure.", "It is also possible to envision other ECA probe types respecting the scope of this invention.", "For example, in U.S. Pat.", "No.", "5,371,461 FIG.", "3, one could dispose of the compensation coil 52 of U.S. Pat.", "No.", "5,371,461 by connecting driver coil 42 of said patent through an impedance bridge.", "Now that we have described means for building channels for detection (orthogonal channels in the preferred embodiment) and lift-off monitoring (absolute channels made out from a pitch-catch sensor arrangement in the preferred embodiment), we describe how these signals are processed in order to obtain a lift-off compensated eddy current probe array without the use of a lift-off reference.", "As shown on FIG.", "6, a reference block 50 comprising a long transversal reference notch 51 is scanned in direction 53 with a given lift-off 52.The probe is first nulled in AIR to generate a reference point for an infinite lift off condition, which will become important later in this discussion.", "The block 50 is then scanned four times with increasing lift off (in the example ; Lift-off A=0 mm ; Lift-off B=0.63 mm ; Lift-off C=1.27 mm ; Lift-off D=1.9 mm) to provide the required background information needed to describe the invention.", "FIG.", "7 shows the impact of lift-off on the reference defect detection amplitude on orthogonal channel 16 impedance plane display.", "In this case, defect amplitude 55 is obtained with lift-off A, defect amplitude 56 is obtained with lift-Off B, defect amplitude 57 is obtained with lift-off C and defect amplitude 58 is obtained with lift-off D. FIG.", "8 shows the impact of lift-off on absolute channel 36 impedance plane display.", "In this case, the total signal amplitude vector 60 results from lift-off A , the total signal amplitude vector 61 results from lift-off B, the total signal amplitude vector 62 results from lift-off C and the total signal amplitude vector 63 results from lift-off D. It is interesting to note that reference notch 51 generates very weak signals on FIG.", "7 compared to the strong lift-off signal.", "For example, with lift A, defect amplitude 64 is orders of magnitude lower than the corresponding total signal amplitude vector 60 resulting from lift A.", "This is a desirable behavior since we want to use the absolute channels for lift-off monitoring only.", "FIG.", "9 shows a graph representing a combined view of the defect amplitude readings 55, 56, 57, 58 on the orthogonal channels and the total signal amplitude vector readings 60, 61, 62 and 63 on the absolute channels relative to the lift-off conditions.", "As seen in the figure, both data series can be fitted by exponential curves 70 and 71.Moreover, the shape of curves 70 and 71 (which is defined by the exponent) is almost the same (e−0.6322*Lift vs. e−0.6557*Lift in this example).", "This observation is very important because it means the ratio “Ortho_Amplitude(Lift)/Abs_Vector(Lift)” is almost independent of the lift.", "For example: 0.3834*e−0.6557*Lift/2.3521 e−0.6322*Lift=0.163*e−0.0235*Lift.", ".", ".", "which is about 0.2 dB/mm variation compared to about 5.7 dB/mm for the orthogonal channel.", "This later observation forms the foundation of the signal processing method of the invention.", "For the following discussion we will approximate “Ortho_Amplitude(Lift)/Abs_Vector(Lift)” as being a constant, pre-determined value totally independent of lift-off.", "It must be understood that the use of the same coil set for defect detection and lift-off monitoring contributes to having similar shaped curves, since the shape of the curve is provided by the magnetic coupling between coils and the inspected part.", "Thus, by dynamically comparing the orthogonal and absolute amplitudes at each measured point (channel), the orthogonal amplitude can be connected for the actual prevailing lift-off during each measurement, without specific knowledge of the lift-off amount, per se.", "We now turn our attention to FIG.", "10, which describes how the probe is to be calibrated with a reference notch such as 51 but without a known reference lift-off.", "We first NULL the probe in AIR, (Step 102) start the acquisition (Step 104), scan the reference notch (Step 106) and define the notch position by manually or automatically indicating where the notch signal begins and ends (Step 108).", "At this point, the information we have is equivalent to the signals presented in FIG.", "8 and FIG.", "7 but for a single unknown lift-off.", "In other words, if notch 51 is scanned in the calibration process with lift-off B, the system should be able to read defect amplitude 56 and total amplitude vector 61 but the actual value of lift-off B will be unknown to both the acquisition system and the user.", "The information available at this point is first used to calibrate the orthogonal channels by applying a calibration GAIN and ROTATION on the raw signal (Step 1010), in order to reach a pre-defined value for the reference defect 51.This pre-defined value (which typically includes both an angular and amplitude target) is common to all orthogonal channels and thus makes it possible to obtain a uniform detection of the reference defect 51 for all orthogonal channels.", "The calibration GAIN and ROTATION for each orthogonal channel is saved in the setup (Step 1012).", "Simultaneously, we use the information generated in [0046] on the absolute channels to calculate the vector length between AIR and the signal's baseline obtained on the calibration block 50 (Step 1014).", "A single absolute vector length value (which could in fact be the average between two absolute channels or other absolute channel combinations adapted to the probe and application) is saved in the setup and associated with its corresponding orthogonal channel.", "For example, in probe 10, if we use absolute channels at position 30a and 30b to compensate the lift-off for the orthogonal channel at position 15a we could average absolute channels at position 30a and 30b and save this pre-determined value in the setup with reference to the channel at position 15a.", "This value will be referenced here as “Absolute_RefLenght(n,Cal_Lift)” where “n” is the orthogonal channel# identifier and “Cal_Lift” is the lift-off condition present during calibration (Step 1016).", "Now looking at FIG.", "11, we will use the information now included in the calibration file and the properties of the “Ortho_Amplitude(Lift)/Abs_Vector(Lift)” ratio to generate a lift compensated orthogonal channel.", "The process described on FIG.", "11 is applied dynamically (during the acquisition) but could easily be applied in post-processing as well (after the acquisition).", "The first step of the process is, again, to NULL the probe in AIR (Step 112) in order to have an infinite lift-off reference.", "After starting the acquisition (Step 114), each new data set corresponding to the impedance plane results (x,y) for one given orthogonal channel at one given scan position is processed separately (Step 116).", "Such data set will be referenced here as “Ortho_raw(n, Lift)” where “n” is the orthogonal channel# identifier and “Lift” is the lift-off condition at the time of measuring the data set.", "The first step in processing is to find the absolute channel total vector length, at the current scan position, corresponding to the orthogonal channel currently being processed (Step 118).", "The relationship between the orthogonal and absolute channel must be the same as previously defined in calibration.", "This value will be referenced here as “Absolute_VLenght(n, Lift)” where “n” is the orthogonal channel# identifier and “Lift” is the lift-off condition at the time of measuring the data set.", "Ortho_raw(n,Lift) is then processed with the following relationship to generate a lift-off compensated orthogonal channel reading; “Ortho_compensated(n, Cal_Lift)=(Ortho_raw(n,Lift)/Absolute_Vlenght(n,Lift))*Absolute_RefLenght(n)” (Step 1110).", "The generated “Ortho_compensated(n,Cal_Lift)” channel is then relatively independent of the current lift-off but is then dependent on the lift-off present during the system calibration.", "To remove this dependency and thus provide a completely lift off independent reading, the calibration GAIN and PHASE are applied to Ortho_compensated(n,Cal_Lift) (Step 1112), until all channels are so processed (Steps 1114, 1116 and 1118).", "As an end result, for a given flaw size, the system should generate a uniform defect signal amplitude no matter which orthogonal channel detects the flaw and without regard to the calibration and inspection lift-off FIG.", "12 shows a hardware configuration of a typical system that can implement the foregoing method.", "The subject EC probe array system comprises a processor 122 or acquisition unit which is operable and controlled through a user interface 124 and which can display test results, commands and the like, display 126.Orthogonal sensors 128, as well as absolute sensors or coils 129 interact, electromagnetically, with the test object 50 to obtain the various signals and to implement the methods described above via software program instructions stored or loaded onto the processor 122, in a manner well known in the art.", "It is important to point out that the described lift compensation method can easily be adapted to operate a multi-frequency inspection.", "This can be done either by generating absolute and orthogonal channels for each frequency or by using a unique set of absolute channels to compensate the multi-frequency orthogonal channels.", "It is also important to mention that while the figures and description describes an ECA probe with eight orthogonal sensors, the method proposed in this invention is applicable as long as the coil configuration makes it possible to build at least one sensor for defect detection and one sensor for lift-off measurement.", "In the foregoing embodiments, the EC sensors have been described and depicted as being coil windings.", "However, as will be recognized by one of skill in the art, other types of magnetic field sensors can be used, such as, for example, GMR (“Giant Magneto Resistance”), AMR (“Anisotropic Magneto Resistance”), or Hall Effect sensors.", "Although the present invention has been described in relation to particular embodiments thereof, many other variations and modifications and other uses will become apparent to those skilled in the art.", "It is preferred, therefore, that the present invention be limited not by the specific disclosure herein, but only by the appended claims." ] ]
Patent_15872719
[ [ "VEHICLE REMOTE CONTROL SYSTEM AND VEHICLE-MOUNTED APPARATUS INCORPORATED IN THE SAME", "A vehicle remote control system including an electronic key pre-registered as a device via which a vehicle can be remote-operated, and a mobile communication device pre-registered as a device that belongs to a user of the vehicle.", "In the system, a vehicle-mounted authentication unit is configured to determine whether or not authentication of the electronic key and the mobile communication device has succeeded, and a vehicle-mounted allowance determination unit is configured to, if it is determined by the vehicle-mounted authentication unit that the authentication of the electronic key and the mobile communication device has succeeded, allow operation of a predetermined vehicle-mounted activation unit." ], [ "1.A vehicle remote control system comprising: an electronic key pre-registered as a device via which a vehicle can be remote-operated; a mobile communication device pre-registered as a device that belongs to a user of the vehicle; a vehicle-mounted authentication unit configured to determine whether or not authentication of the electronic key and the mobile communication device has succeeded; and a vehicle-mounted allowance determination unit configured to, if it is determined by the vehicle-mounted authentication unit that the authentication of the electronic key and the mobile communication device has succeeded, allow operation of a predetermined vehicle-mounted activation unit, wherein at least one of the electronic key and the mobile communication device comprises: a primary authentication unit configured to, if determining that both the electronic key and the mobile communication device are communicable with each other and carried by the user, determine that authentication between the electronic key and the mobile communication device has succeeded; and a transmit processing unit configured to, if it is determined by the primary authentication unit that the authentication between the electronic key and the mobile communication device has succeeded, transmit to the vehicle via a transmitter an authentication signal including a signal indicative of the electronic key and the mobile communication device being pre-registered devices, wherein the vehicle-mounted authentication unit is configured to, upon receipt of the authentication signal, authenticate the authentication signal, and upon successful authentication of the authentication signal, determine that the authentication of the electronic key and the mobile communication device has succeeded." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>In accordance with a first exemplary embodiment of the present invention, there is provided a vehicle remote control system including: an electronic key pre-registered as a device via which a vehicle can be remote-operated; a mobile communication device pre-registered as a device that belongs to a user of the vehicle; a vehicle-mounted authentication unit configured to determine whether or not authentication of the electronic key and the mobile communication device has succeeded; and a vehicle-mounted allowance determination unit configured to, if it is determined by the vehicle-mounted authentication unit that the authentication of the electronic key and the mobile communication device has succeeded, allow operation of a predetermined vehicle-mounted activation unit.", "In accordance with a second exemplary embodiment of the present invention, there is provided a vehicle-mounted apparatus incorporated in a vehicle remote control system, where the system includes an electronic key pre-registered as a device via which a vehicle can be remote-operated and a mobile communication device pre-registered as a device that belongs to a user of the vehicle.", "The apparatus includes: a vehicle-mounted authentication unit configured to determine whether or not authentication of the electronic key and the mobile communication device has succeeded; and a vehicle-mounted allowance determination unit configured to, if it is determined by the vehicle-mounted authentication unit that the authentication of the electronic key and the mobile communication device has succeeded, allow operation of a predetermined vehicle-mounted activation unit.", "It is determined whether or not only authentication of the electronic key but also authentication of the mobile communication device has succeeded.", "If the authentication of the electronic key and the authentication of the mobile communication device have both succeeded, operation of the activation unit is allowed or permitted.", "Therefore, even if only the electronic key is stolen, a person who stole the electronic key is unable to operate the activation unit, which can improve the security of the system." ], [ "CROSS-REFERENCE TO RELATED APPLICATION This application is based on and claims the benefit of priority from earlier Japanese Patent Application No.", "2014-238977 filed Nov. 26, 2014, and is a continuation of U.S. application Ser.", "No.", "14/951,238 filed on Nov. 24, 2015, the descriptions of which is incorporated herein by reference.", "BACKGROUND Technical Field The present invention relates to a vehicle remote control system that allows a user to instruct operation of a vehicle-mounted actuation unit via a device carried by the user, and to a vehicle-mounted apparatus incorporated in the system.", "Related Art An electronic key system is known as a system that allows a vehicle door to be locked or unlocked in response to an instruction from a device carried by a vehicle user.", "A variety of developments to increase security have been experienced in electronic key systems.", "For example, the system as disclosed in Japanese Patent Application Laid-Open Publication No.", "2001-027063 is configured to use a rolling code that changes in value each time as a plaintext used for authentication.", "The electronic key may be stolen even if the code is modified to prevent the code from being reproduced, which is likely to permit vehicle theft.", "Particularly, when an automatically driven vehicle that can travel to a person carrying the electronic key when the electronic key is pressed is in practical use, it is ever more desired to improve the security of the vehicle remote control system.", "In consideration of the foregoing, exemplary embodiments of the present invention are directed to providing a secure vehicle remote control system and a vehicle-mounted apparatus incorporated in the system.", "SUMMARY In accordance with a first exemplary embodiment of the present invention, there is provided a vehicle remote control system including: an electronic key pre-registered as a device via which a vehicle can be remote-operated; a mobile communication device pre-registered as a device that belongs to a user of the vehicle; a vehicle-mounted authentication unit configured to determine whether or not authentication of the electronic key and the mobile communication device has succeeded; and a vehicle-mounted allowance determination unit configured to, if it is determined by the vehicle-mounted authentication unit that the authentication of the electronic key and the mobile communication device has succeeded, allow operation of a predetermined vehicle-mounted activation unit.", "In accordance with a second exemplary embodiment of the present invention, there is provided a vehicle-mounted apparatus incorporated in a vehicle remote control system, where the system includes an electronic key pre-registered as a device via which a vehicle can be remote-operated and a mobile communication device pre-registered as a device that belongs to a user of the vehicle.", "The apparatus includes: a vehicle-mounted authentication unit configured to determine whether or not authentication of the electronic key and the mobile communication device has succeeded; and a vehicle-mounted allowance determination unit configured to, if it is determined by the vehicle-mounted authentication unit that the authentication of the electronic key and the mobile communication device has succeeded, allow operation of a predetermined vehicle-mounted activation unit.", "It is determined whether or not only authentication of the electronic key but also authentication of the mobile communication device has succeeded.", "If the authentication of the electronic key and the authentication of the mobile communication device have both succeeded, operation of the activation unit is allowed or permitted.", "Therefore, even if only the electronic key is stolen, a person who stole the electronic key is unable to operate the activation unit, which can improve the security of the system.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is an overall diagram of a vehicle remote control system in accordance with a first embodiment of the present invention; FIG.", "2 is a block diagram of a parking lot monitor of FIG.", "1; FIG.", "3 is a block diagram of a central server of FIG.", "1; FIG.", "4 is a block diagram of a vehicle-mounted system of FIG.", "1; FIG.", "5 is a block diagram of an electronic key of FIG.", "1; FIG.", "6 is a block diagram of a smartphone of FIG.", "1; FIG.", "7 is a flowchart of a process performed in a controller of a smartphone in accordance with the first embodiment; FIG.", "8 is a flowchart of a process performed in a controller of a vehicle-mounted system at startup of automatic driving in accordance with the first embodiment; FIG.", "9 is an example of a travel path along which an automatically driven vehicle travels to a user; FIG.", "10 is a flowchart of a process performed in the controller of the vehicle-mounted system after automatic driving is started in accordance with the first embodiment; FIG.", "11 is an example of a driving condition notification image displayed on a display of the smartphone in accordance with the first embodiment; FIG.", "12 is an example of a driving condition notification image displayed on a display of a smartphone in accordance with a second embodiment; FIG.", "13 is a flowchart of a process performed in a controller of an electronic key in accordance with a third embodiment; FIG.", "14 is a flowchart of a process performed in a controller of an electronic key in accordance with a fourth embodiment; FIG.", "15 is a flowchart of a process performed in a controller of the vehicle-mounted system in accordance with the fourth embodiment; and FIG.", "16 is a flowchart of a process performed in a controller of a smartphone in accordance with the fourth embodiment.", "DESCRIPTION OF SPECIFIC EMBODIMENTS Embodiments of the present invention now will be described more fully hereinafter with reference to the accompanying drawings, in which embodiments of the invention are shown.", "This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.", "Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.", "Like numbers refer to like elements throughout.", "First Embodiment A vehicle remote control system 1 in accordance with a first embodiment of the present invention will now be explained with reference to FIG.", "1.The vehicle remote control system 1 is configured to allow a user at a location remote from an automatically driven vehicle 2 to make the automatically driven vehicle 2 travel to the user's location.", "The vehicle remote control system 1 includes, as shown in FIG.", "1, a parking lot monitor 10, a central server 20, an electronic key 30, a smartphone 40, and a vehicle-mounted system 100.The vehicle-mounted system 100 is mounted in the automatically driven vehicle 2.The electronic key 30 and the smartphone 40 are carried by the user 3 of the automatically driven vehicle 2.Automatic driving of the automatically driven vehicle 2 is enabled by the vehicle-mounted system 100.Manned driving of the automatically driven vehicle 2 is enabled as well.", "As shown in FIG.", "1, the vehicle-mounted system 100 includes a data communication module (DCM) 106, a first near field communication unit (NC1) 115, a second near field communication unit (NC2) 116, and a third near field communication unit (NC3) 117.The other components of the vehicle-mounted system 100 will be described later with reference to FIG.", "4.The DCM 106 is configured to communicate wirelessly with the central server 20 and the smartphone 40 through a public communication network.", "The central server 20 and the smartphone 40 are also communicable with each other through the public communication network.", "The first near field communication unit 115 is configured to communicate with the electronic key 30 using frequencies in the UHF band to receive, from the electronic key 30, a signal indicative of locking or unlocking of doors of the automatically driven vehicle 2 or a signal indicative of start or stop of automatic driving.", "The second near field communication unit 116 is configured to communicate wirelessly with the smartphone 40 within a communication range of tens to hundreds of meters in compliance with a near field communication standard, such as Bluetooth (registered trademark).", "The second near field communication unit 116 may communicate wirelessly with the electronic key 30 as well.", "The third near field communication unit 117 is configured to communicate with the parking lot monitor 10 in compliance with a communication standard used for vehicle-to-infrastructure and vehicle-to-vehicle communication.", "(Parking Lot Monitor) The parking lot monitor 10 is installed in a parking lot to detect various parking lot information, such as information about objects present in the parking lot.", "As shown in FIG.", "2, the parking lot monitor 10 includes a camera 11, a vehicle-to-infrastructure communication unit 12, and a controller 13.The camera 11 is installed at a position at which the camera 11 can capture an entirety of the parking lot.", "If a single camera cannot capture the entirety of the parking lot, a plurality of cameras may be installed at different positions in the parking lot.", "The vehicle-to-infrastructure communication unit 12 is configured to communicate with the third near field communication unit 117 of the vehicle-mounted system 100 in compliance with the communication standard used for vehicle-to-infrastructure and vehicle-to-vehicle communication, where, for example, the operating frequency is in the 700 MHz band, the 5.8 GHz band, or the 5.9 GHz band and the communication range is in the order of tens to hundreds of meters.", "The parking lot monitor 10 and the vehicle-mounted system 100 may communicate with each other via another communication unit than the vehicle-to-infrastructure communication unit 12.The controller 13 may be a microcomputer including a central processing unit (CPU), a read-only memory (ROM), a random-access memory (RAM) and the like.", "Various functions may be implemented by the CPU executing computer programs stored in the ROM.", "For example, the controller 13 is configured to analyze an image captured by the camera 11 to detect a position and a type of an object present in a lane of the parking lot, and transmit the detection result via the vehicle-to-infrastructure communication unit 12.Additionally, a map of the parking lot may be transmitted via the vehicle-to-infrastructure communication unit 12.", "(Central Server) The central server 20 includes, as shown in FIG.", "3, a wide area communication unit 21, a storage 22, and a controller 23.The wide area communication unit 21 is configured to conduct wide area communication via connection to a public communication network.", "The storage 22 has map data stored therein.", "The map data includes, as well as road data, information about locations and travel directions of lanes in each of at least some of the parking lots on the map.", "The controller 23 may be a microcomputer including a central processing unit (CPU), a read-only memory (ROM), a random-access memory (RAM) and the like.", "The controller 23 may control the wide area communication unit 21 by the CPU executing computer programs stored in the ROM.", "The wide area communication unit 21 is controlled by the controller 23 to communicate with a wide area communication unit 42 of the smartphone 40 and the DCM 106 of the vehicle-mounted system 100.", "(Vehicle-Mounted System) The vehicle-mounted system 100 includes many components, as shown in FIG.", "4.The controller 130 and the other components of the vehicle-mounted system 100 may be connected directly to each other, or may be connected via an on-board local area network (LAN).", "The controller 130, as a vehicle-mounted apparatus, is configured to control the other components of the vehicle-mounted system 100 as shown in FIG.", "4.The controller 130 may be formed of a single microcomputer including a central processing unit (CPU), a read-only memory (ROM), a random-access memory (RAM) and the like, or may be formed of a plurality of such microcomputers.", "The controller 130 serves as a vehicle-mounted authentication unit 131, an allowance determination unit 132, and an automatic-driving control unit 133, which are described later.", "Some or all of the functions of the controller 130 may be implemented by hardware, for example, by a single integrated circuit (IC) or a plurality of integrated circuits.", "A GNSS receiver 101 is configured to receive radio waves from satellites of the global navigation satellite system (GNSS) to detect a location of the GNSS receiver 101 and input the detected location to the controller 130.The location detected by the GNSS receiver 101 is indicative of a location of the automatically driven vehicle 2.A front-facing camera 102 is configured to capture an image of a predetermined area forward of the automatically driven vehicle 2.A rear-facing camera 103 is configured to capture an image of a predetermined area rearward of the automatically driven vehicle 2.The images captured by the front-facing camera 102 and the rear-facing camera 103 of the automatically driven vehicle 2 are inputted to the controller 130.A sonar 104 is disposed on at least one of a front end face, a rear end face, and left and right side faces of the automatically driven vehicle 2 to detect a position of an object around the automatically driven vehicle 2.The position of the object detected by the sonar 104 is inputted to the controller 130.A radar 105, which may be a millimeter-wave radar or a laser radar, is provided forward or/and rearward of the automatically driven vehicle 2.The radar 105 provided forward of the automatically driven vehicle 2 is configured to detect an object present in a probe-wave irradiated area forward of the automatically driven vehicle 2.The radar 105 provided rearward of the automatically driven vehicle 2 is configured to detect an object present in a probe-wave irradiated area rearward of the automatically driven vehicle 2.The position of the object detected by the radar 105 is inputted to the controller 130.A data communication module (DCM) 106 is configured to conduct wide area wireless communication via a public communication network.", "An acceleration sensor 107 is configured to detect an acceleration experienced by the automatically driven vehicle 2.More specifically, the acceleration sensor 107 may be configured to detect an acceleration or accelerations along a single axis or two axes, preferably, accelerations along the three axes.", "A wheel speed sensor 108 is configured to detect a rotational speed of each wheel of the automatically driven vehicle 2.A vehicle-speed sensor 109 is configured to detect a speed of the automatically driven vehicle 2.A gyro sensor 110 is configured to detect a rate of change in each of an azimuth angle, a roll angle, and a pitch angle of the automatically driven vehicle 2.A steering angle sensor 111 is configured to detect a steering angle of the automatically driven vehicle 2.Detected values of the acceleration sensor 107, the wheel speed sensor 108, the vehicle-speed sensor 109, the gyro sensor 110, and the steering angle sensor 111 are inputted to the controller 130.An external memory 112 is configured to store therein codes used to authenticate the electronic key 30 and the smartphone 40.The presence of the codes stored in the external memory 112 means that the electronic key 30 and the smartphone 40 are registered with the vehicle-mounted system 100.The display unit 113 is configured to display whether or not the automatically driven vehicle 2 is in automatic driving.", "When the automatically driven vehicle 2 is in automatic driving, monitoring of surroundings monitoring sensors is displayed, where the surroundings monitoring sensors include the front-facing camera 102, the rear-facing camera 103, the sonar 104, and the radar 105.A speaker 114 is configured to, during automatic driving of the automatically driven vehicle 2, output a sound in the vicinity of the automatically driven vehicle 2 to indicate that the automatically driven vehicle 2 is in automatic driving.", "The speaker 114 is further configured to output a sound in the vicinity of the automatically driven vehicle 2 prior to start of automatic driving to indicate the start of automatic driving.", "Another speaker may be provided to output a sound in a passenger compartment.", "The first near field communication unit 115, the second near field communication unit 116, and the third near field communication unit 117 have been already explained.", "Hence, any repetitive description about them is omitted.", "A low frequency (LF) transmitter 118 is configured to transmit a baseband signal received from the controller 130 as a radio wave in the LF band of 30 kHz-300 kHz (hereinafter referred to as an LF radio wave).", "An antenna of the LF transmitter 118 has a communication range of several meters.", "Map data 119 is stored in a predetermined storage.", "As with the map data stored in storage 22 of the central server 20, the map data 119 includes, as well as road data, information about lanes in the parking lots on the map.", "The information about lanes in the parking lots on the map may include information about whether or not there is a rule for travel directions of the lanes for at least some of the parking lots on the map.", "The storage storing the map data 119 may be another memory than the external memory 112, or may be included in the external memory 112.A steering actuator 120 is configured to axially drive a rack shaft to steer the steered wheels.", "A vehicle drive-power generator 121, such as an internal-combustion engine, an electrical motor, or a combination of them, is configured to generate drive power for driving the automatically driven vehicle 2.A drive-power detector 122 is configured to detect the drive power generated by the drive-power generator 121.A detected drive power value is inputted to the controller 130.A brake actuator 123 is configured to hydraulically or electrically compress a brake pad to decrease a rotational speed of a vehicle wheel.", "A brake switching mechanism 124 is hydraulically or electrically controlled to switch a parking brake from locked to unlocked, and vice versa.", "The steering actuator 120, the drive-power generator 121, the brake actuator 123, the brake switching mechanism 124 are controlled by the controller 130.", "(Electronic Key) The electronic key 30 is registered with the vehicle-mounted system 100 as a device capable of remotely controlling the automatically driven vehicle 2.As shown in FIG.", "5, the electronic key 30 includes an LF receiver 31, a UHF transmitter 32, a near field communication unit 33, a GNSS receiver 34, a console 35, a display 36, and a speaker 37.The LF receiver 31 is configured to receive the LF radio wave transmitted by the LF transmitter 118 of the vehicle-mounted system 100, demodulate the received radio wave to extract the baseband signal, and output the extracted baseband signal to the controller 38.The UHF transmitter 32 is configured to modulate a signal received from the controller 38 and transmit the modulated signal as a UHF radio wave.", "The near field communication unit 33 is configured to communicate wirelessly with the second near field communication unit 116 of the vehicle-mounted system 100 in compliance with the same near field communication standard as used in the second near field communication unit 116.A GNSS receiver 34, which has the same configuration as the GNSS receiver 101 of the vehicle-mounted system 100 has, is configured to receive radio waves from the satellites of the global navigation satellite system to detect a current location of the GNSS receiver 34 based on the radio waves received from the satellites and input the detected current location to the controller 38.A console 35 is provided with three switches 35a-35c, that is, a door lock switch 35a, a door unlock switch 35b, an automatic driving switch 35c.", "The door lock switch 35a is operated to transmit an instruction to lock doors of the automatically driven vehicle 2.The door unlock switch 35b is operated to transmit an instruction to unlock the doors of the automatically driven vehicle 2.The automatic driving switch 35c is operated to start or stop automatic driving of the automatically driven vehicle 2.When the automatic driving switch 35c is activated while the automatically driven vehicle 2 is not in automatic driving, an instruction to start automatic driving of the automatically driven vehicle 2 will be transmitted.", "When the automatic driving switch 35c is activated while the automatically driven vehicle 2 is in automatic driving, an instruction to stop automatic driving of the automatically driven vehicle 2 will be transmitted.", "Alternatively, two switches may be separately provided, one for starting automatic driving and the other for stopping automatic driving.", "A removable cover may be provided for preventing the automatic driving switch 35c from being operated.", "Ordinarily, the automatic driving switch 35c is covered with the removable cover and unexposed.", "When automatic driving is requested, the cover is removed so that the automatic driving switch 35c can be operated.", "This can prevent the automatic driving switch 35c from being inadvertently activated.", "Various messages, such as a message indicative of whether or not the automatically driven vehicle 2 is in automatic driving, may be displayed on the display 36.", "(Smartphone) The smartphone 40 serving as a mobile communication device, as with the electronic key 30, is pre-registered with the vehicle-mounted system 100 as belonging to a user 3 of the automatically driven vehicle 2.The smartphone 40 is also registered with the electronic key 30.As shown in FIG.", "6, the smartphone 40 includes a GNSS receiver 41, a wide area communication unit 42, an external memory 43, a console 44, a display 45, a speaker 46, and a near field communication unit 47.A GNSS receiver 41, which has the same configuration as the GNSS receiver 101 or 41 of the vehicle-mounted system 100 or the electronic key 30 has, is configured to receive radio waves from the satellites of the global navigation satellite system to detect a current location of the GNSS receiver 41 based on the radio waves received from the satellites and input the detected current location to the controller 48.The wide area communication unit 42 is configured to conduct wide area communication via connection to the public communication network.", "The smartphone 40 is configured to communicate with the central server 20 and the DCM 106 of the vehicle-mounted system 100 via the wide area communication unit 42.The external memory 43 may be a writable non-volatile memory, such as a flash memory or the like.", "Some of applications installed on the smartphone 40 are stored in the external memory 43.In the present embodiment, an automatic driving application 43a is stored in the external memory 43.The automatic driving application 43a is executed when the user 3 guides the automatically driven vehicle 2 in automatic driving.", "Execution of the automatic driving application 43a allows the user 3 to start or stop automatic driving, determine a location of the automatically driven vehicle 2 during automatic driving, or check a condition surrounding the automatically driven vehicle 2 via the smartphone 40.The console 44 may include a touch panel superimposed on a viewing surface of the display 45 or a mechanical switch surrounding the display 45.The user 3 operates the console 44 to provide an automatic-driving start instruction to start automatic driving or an automatic-driving stop instruction to stop automatic driving.", "The display 45 is configured to, during execution of the automatic driving application 43a, display whether or not the automatically driven vehicle 2 is in automatic driving or the condition surrounding the automatically driven vehicle 2, or the like.", "The speaker 46 is configured to output a sound that indicates that automatic driving has been started or a sound that indicates automatic driving has been stopped.", "The near field communication unit 47 is configured to communicate wirelessly with the second near field communication unit 116 of the vehicle-mounted system 100 and the near field communication unit 33 of the electronic key 30 in compliance with the same near field communication standard as used in the second near field communication unit 116 and the near field communication unit 33.", "(Process at Startup of Automatic Driving) Processes performed in the electronic key 30, the smartphone 40, and the vehicle-mounted system 100 at startup of automatic driving will now be explained.", "The controller 48 of the smartphone 40 performs the process shown in FIG.", "7 periodically.", "This process is initiated when an automatic driving application 43a is launched.", "The controller 48 of the smartphone 40 includes a primary authentication unit 48a and a transmit processing unit 48b.", "The primary authentication unit 48a of the smartphone 40 is responsible for execution of steps S11-S16.The transmit processing unit 48b of the smartphone 40 is responsible for execution of steps S17, S18.In step S11, a startup image is displayed on the display 45.At least an automatic driving start button for indicating start of automatic driving is displayed in the startup image.", "In step S12, authentication is performed by communicating with the electronic key 30, where it is determined whether or not the smartphone 40 and the electronic key 30 have been pre-registered with each other.", "The registration of the smartphone 40 with the electronic key 30 and the registration of the electronic key 30 with the smartphone 40 are performed by the user 3 or an automobile retailer employee.", "This authentication may be performed using an automatic authentication function effected between two devices near each other such as defined in compliance with the well-known Bluetooth communication standard prior to the automatic driving start button being pressed.", "In step S13, it is determined whether or not the authentication has succeeded.", "If it is determined that the authentication has failed, the process of FIG.", "7 ends.", "If it is determined that the authentication has succeeded, then the process proceeds to step S14.In step S14, it is determined whether or not the automatic driving start button displayed on the display 45 has been operated.", "If it is determined that the automatic driving start button displayed on the display 45 has not been operated, then step S14 is repeated.", "Although not shown in FIG.", "7, in the event that the automatic driving application 43a is terminated by the user 3 while step S14 is repeatedly performed, the process of FIG.", "7 ends.", "If it is determined that the automatic driving start button displayed on the display 45 has been operated, then the process proceeds to step S15.In step S15, a distance between the electronic key 30 and the smartphone 40 is calculated.", "For example, the distance between the electronic key 30 and the smartphone 40 may be calculated based on the strength of a radio wave transmitted by the near field communication unit 33 of the electronic key 30 and then received by the near field communication unit 47 of the smartphone 40.Since the radio wave strength decreases with distance, the distance can be calculated from the radio wave strength.", "Alternatively, the distance between the electronic key 30 and the smartphone 40 may be calculated from the current locations detected by the GNSS receivers 34, 41 of the electronic key 30 and the smartphone 40.In step S16, it is determined whether or not the distance calculated in step S15 is equal to or less than a threshold distance (referred to as a mobile distance).", "The mobile distance is a predefined distance such that, if a distance between the electronic key 30 and the smartphone 40 is equal to or less than the mobile distance, it can be assumed that both the electronic key 30 and the smartphone 40 are carried by the user 3.The mobile distance may be set to about several meters.", "This because that the user 3 may wear one of the electronic key 30 and the smartphone 40 and carry the other in a bag that may be placed at a short distance from the user 3.Alternatively, step S15 may be skipped, and in step S16, it may be determined whether or not the distance between the electronic key 30 and the smartphone 40 is equal to or less than the mobile distance by comparing the strength of the received radio wave with a radio wave strength threshold.", "If in step S16 it is determined that the distance is greater than the mobile distance, the process of FIG.", "7 ends.", "If in step S16 it is determined that the distance is equal to or less than the mobile distance, then the process of FIG.", "7 proceeds to step S17.In step S17, a current location of the smartphone 40 is acquired from the GNSS receiver 41.Alternatively, the current location may be acquired from the GNSS receiver 34 of the electronic key 30.In step S18, an automatic driving instruction signal (as an authentication signal) including the current location acquired in step S17, a code used to authenticate the smartphone 40, and an automatic driving instruction signal for instructing the start of automatic driving transmitted from the near field communication unit 47 to the vehicle-mounted system 100.The controller 130 of the vehicle-mounted system 100 performs a process shown in FIG.", "8 periodically when the automatically driven vehicle 2 is in a stationary state.", "When an ignition switch is off, the automatically driven vehicle 2 is in the stationary state.", "Therefore, the process of FIG.", "8 may be performed when the ignition switch is off.", "In addition, even when the ignition switch is on, the process of FIG.", "8 may be performed when the shift position is at a parking position.", "The controller 130 of the vehicle-mounted system 100 includes the authentication unit 131, the allowance determination unit 132, and the automatic-driving control unit 133.The authentication unit 131 is responsible for execution of steps S21, S22 of FIG.", "8.The allowance determination unit 132 is responsible for execution of steps S23-S25 of FIG.", "8.The automatic-driving control unit 133 is responsible for execution of steps S26 of FIG.", "8.In step S21, it is determined whether or not the automatic driving instruction signal has been received.", "As described above, the automatic driving instruction signal is transmitted step S18 of FIG.", "7 from the smartphone 40.If in step S21 it is determined that the automatic driving instruction signal has not been received, then the process of FIG.", "8 ends.", "If in step S21 it is determined that the automatic driving instruction signal has been received, then the process of FIG.", "8 proceeds to step S22.In step S22, authentication for the automatic driving instruction signal is processed, where the code included in the automatic driving instruction signal and the code stored in the external memory 112 are matched.", "Step S22 is allowed to be performed if in step S13 it is determined that the authentication has succeeded and if in step 16 it is determined that the distance between the electronic key 30 and the smartphone 40 is equal to or less than the mobile distance.", "In the case of successful authentication in step S22, it can be determined that both the authentication of the electronic key 30 and the authentication of the smartphone 40 have already succeeded.", "This is because the authentication in step S22 can be processed successfully only if the authentication in step S13 has succeeded and it has been determined in step S16 that the distance between the electronic key 30 and the smartphone 40 is equal to or less than the mobile distance.", "In step S23, it is determined whether or not the authentication in step S22 has succeeded.", "If the authentication in step S22 has failed, then the process proceeds to step S24.In step S24, a disallowance notification (as a disallowance signal) is transmitted from the second near field communication unit 116 (as a transmitter) to the smartphone 40 that has transmitted the automatic driving instruction signal.", "The smartphone 40 receives the disallowance notification via the near field communication unit 47.Upon receipt of the disallowance notification via the near field communication unit 47, the controller 48 controls the display 45 to display that automatic driving is disallowed.", "The second near field communication unit 116 may be replaced with any other communication unit that is wirelessly communicable with the smartphone 40.If in step S23 it is determined that the authentication has succeeded, then the process proceeds to step S25, where automatic driving is determined to be allowed and an automatic-driving start notification is transmitted from the second near field communication unit 116 to the smartphone 40.Upon receipt of the automatic-driving start notification at the smartphone 40, an indication that automatic driving is about to start is displayed on the display 45.In step S26, a travel path 7 along which the automatically driven vehicle 2 is automatically driven to a location of the user 3 is set up.", "FIG.", "9 is an example of the travel path 7 where the user 3 is lying at an entrance of a parking lot.", "In the example of FIG.", "9, only one-way lanes are provided as indicated by arrows 5.In such a case, the automatically driven vehicle 2 may travel not along a shortest path 6 to the user 3, but along the travel path 7, where the automatically driven vehicle 2 may travel further from the user 3 along part of the travel path 7.Subsequently to step S26, automatic driving is started.", "More specifically, a process of FIG.", "10 is performed.", "(Process Performed in Vehicle-Mounted System During Automatic Driving) The entire process of FIG.", "10 is performed by the automatic-driving control unit 133.In step S31, the brake switching mechanism 124 is activated to release or unlock the parking brake.", "At the same time, the brake actuator 123 is activated to prevent the wheels from rotating.", "In step S32, the surroundings monitoring sensors are activated to start surroundings monitoring.", "In step S33, sounding an alert from the speaker 114 (as a warning unit) is started to ensure that persons in the parking lot are aware that the automatically driven vehicle 2 is in automatic driving.", "Thereafter, the speaker 114 sounds the alert periodically.", "In step S34, the automatically driven vehicle starts moving or running.", "The automatically driven vehicle may start moving after a certain period of time elapses after sounding the alert from the speaker 114 is started.", "This period of time may be several to tens of seconds.", "During automatic driving, the steering actuator 120 is used to control a traveling direction of the automatically driven vehicle 2 while controlling the speed of the automatically driven vehicle 2 by controlling the drive-power generator 121 and the brake actuator 123.The automatically driven vehicle 2 thereby travels along the travel path 7 set up prior to the start of automatic driving.", "During automatic driving, the surroundings monitoring is conducted periodically by using the front-facing camera 102, the rear-facing camera 103, the sonar 104, and the radar 105.In step S35, based on results of the surroundings monitoring, it is determined whether or not there is a person within a predetermined distance from the automatically driven vehicle 2.The determination may be made by using the surroundings monitoring sensors or may be made not only by using the surroundings monitoring sensors, but also by acquiring a location of the person from the parking lot monitor 10.If in step S35 it is determined that there is a person within the predetermined distance from the automatically driven vehicle 2, then the process proceeds to step S36.In step S36, the automatically driven vehicle 2 is decelerated so that the person detected around the automatically driven vehicle 2 can pay attention to the presence of the automatically driven vehicle 2.The person detected around the automatically driven vehicle 2 can know that the automatically driven vehicle 2 has recognized the presence of the person.", "If in step S35 it is determined that there is no person within the predetermined distance from the automatically driven vehicle 2, or after the automatically driven vehicle 2 is decelerated, the process proceeds to step S37.In step S37, a current location of the automatically driven vehicle 2 is detected.", "The current location of the automatically driven vehicle 2 is detected using the GNSS receiver 101.Alternatively, the current location of the automatically driven vehicle 2 may be detected based on a trajectory produced by using the vehicle-speed sensor 109, the wheel speed sensor 108, the acceleration sensor 107, the steering angle sensor 111, and a location at which the automatically driven vehicle 2 is parked in the parking lot determined by the parking lot map.", "The current location of the automatically driven vehicle 2 may be acquired from the parking lot monitor 10 since the parking lot monitor 10 monitors a location of the automatically driven vehicle 2 in the parking lot.", "In step S38, a driving condition signal (as an surroundings condition signal) including the current location of the automatically driven vehicle 2 detected in step S37 and the latest forward and rearward images is transmitted from the second near field communication unit 116 or the DCM 106 to the smartphone 40.The forward image is an image captured by the front-facing camera 102, and the rearward image is an image captured by the rear-facing camera 103.In step S39, it is determined whether or not the automatically driven vehicle 2 has reached the location of the user 3.If in step S39 it is determined that the automatically driven vehicle 2 has not reached the location of the user 3 yet, then the process returns to step S35 and automatic driving is continued.", "If in step S39 it is determined that the automatically driven vehicle 2 has reached the location of the user 3, then the process proceeds to step S40.In step S40, a parking process is performed, where the parking brake is locked by deactivating the drive-power generator 121 and activating the brake switching mechanism 124.", "(Presentation of Smartphone During Automatic Driving) The smartphone 40 receives via the near field communication unit 47 or the wide area communication unit 42 (as a receiver) the driving condition signal transmitted in step S38 from the vehicle-mounted system 100.Upon receipt of the driving condition signal via the near field communication unit 47 or the wide area communication unit 42, the controller 48 displays a driving condition notification image 480 as shown in FIG.", "11 on the display 45.The driving condition notification image 480 includes a location notification image 481, a forward image 482, a rearward image 483, and a stop button 484.The location notification image 481 is a map image for notifying the user 3 of the current location of the automatically driven vehicle 2, which includes a starting point marking 481a, a destination marking 481b, a current location marking 481c, and a planned route 481d.", "A position of the current location marking 481c in the location notification image 481 is determined based on the current location of the automatically driven vehicle 2 detected in step S37.The starting point marking 481a represents a location of the automatically driven vehicle 2 at the start of automatic driving.", "The destination marking 481b represents a location of the smartphone 40.The planned route 481d represents the travel path 7 determined in step S26.The forward image 482 is the latest forward image captured by the front-facing camera 102.The rearward image 483 is the latest rearward image captured by the rear-facing camera 103.The stop button 484 is a button operated by the user 3 to stop the automatically driven vehicle 2.The driving condition signal is sequentially transmitted until the automatically driven vehicle 2 arrives at the user 3.Therefore, the driving condition notification image 480 as shown in FIG.", "11 is displayed on the display 45 of the smartphone 40 until the automatically driven vehicle 2 arrives at the user 3.", "(Advantages) In the vehicle remote control system 1 of the first embodiment, upon successful authentication with the electronic key 30 (in step S13), the smartphone 40 transmits the automatic driving instruction signal to the vehicle-mounted system 100 (in step S18).", "If it is determined that the authentication of the automatic driving instruction signal received from the smartphone 40 has succeeded (in step S23), automatic driving is allowed (in step S25).", "Therefore, the successful authentication of the automatic driving instruction signal received from the smartphone 40 allows it to be determined that the authentication of the electronic key 30, as well as the authentication of the smartphone 40, has succeeded.", "Thus, in the present embodiment, the determination that the authentication of the smartphone 40 and the electronic key 30 has succeeded allows the vehicle-mounted system 100 to start automatic driving.", "With this configuration, even if only the electronic key 30 is stolen, the person who stole the electronic key 30 is unable to operate the console of the smartphone 40 that is remote from the electronic key 30, which can improve the security of the system.", "In addition, in the present embodiment, the automatic driving instruction signal is transmitted from the smartphone 40, and the driving condition notification image 480 is displayed on the display 45 of the smartphone 40, where the driving condition notification image 480 indicates the location of the automatically driven vehicle 2 during automatic driving and the images of surroundings of the automatically driven vehicle 2.This configuration allows the user 3 to start automatic driving and monitor the automatically driven vehicle 2 during automatic driving via the smartphone 40.If automatic driving is disallowed, the disallowance notification is displayed on the display 45 of the smartphone 40.This allows the user 3 to avoid a situation where the user 3 waits for the automatically driven vehicle 2 to reach the location of the user 3 despite automatic driving having not been started.", "When starting automatic driving, the vehicle-mounted system 100 sounds the alert (in step S33) after the successful authentication (in step S23) and prior to the automatically driven vehicle 2 starting to move.", "This allows a person around the automatically driven vehicle 2 to pay attention to motion of the automatically driven vehicle 2 before the automatically driven vehicle 2 starts to move.", "If a person is detected within a predetermined distance from the automatically driven vehicle 2 during automatic driving, the automatically driven vehicle 2 decelerates (in step S36).", "This allows the person detected around the automatically driven vehicle 2 to know that the automatically driven vehicle 2 has recognized the presence of the person.", "In addition, the deceleration of the automatically driven vehicle 2 facilitates the person detected around the automatically driven vehicle 2 avoiding the automatically driven vehicle 2.During automatic driving, the driving condition notification image 480 is displayed on the display 45 of the smartphone 40.Looking at the driving condition notification image 480, the user 3 can know the location of the automatically driven vehicle 2 and surroundings of the automatically driven vehicle 2 until the automatically driven vehicle 2 reaches the location of the user 3.If, looking at the forward image 482 and the rearward image 483, the user 3 determines that the automatically driven vehicle 2 should be stopped, the user 3 may operate the stop button 484 to stop the automatically driven vehicle 2.Second Embodiment A second embodiment of the present invention will now be explained.", "In the present and subsequent embodiments, elements having the same functions as in the first embodiment are assigned the same numbers, except where specified otherwise, and will not be described again for brevity.", "In the present embodiment, in step S38 of FIG.", "10, a driving condition signal that, instead of the surroundings images, includes an object position detected by the surroundings monitoring sensors is transmitted.", "Upon receipt of the driving condition signal, the smartphone 40 displays a driving condition notification image 480a as shown in FIG.", "12 on the display 45.The driving condition notification image 480a includes the location notification image 481 and the stop button 484 that are the same as included in the driving condition notification image 480 of the first embodiment.", "The driving condition notification image 480a includes an object position notification image 485 instead of the forward image 482 and the rearward image 483.The object position notification image 485 is an image in which a plurality of location notification blocks 485b are formed around a profile 485a of the automatically driven vehicle 2.A location notification block 485b corresponding to the object position included in the driving condition signal is different in color from another location notification block 485b in which there is no object.", "In the second embodiment, the driving condition notification image 480a as shown in FIG.", "12 is displayed on the display 45 of the smartphone 40.Therefore, if, looking at the position notification image 485, the user 3 determines that the automatically driven vehicle 2 has to be stopped, the user 3 can stop the automatically driven vehicle 2 by operating the stop button 484.Third Embodiment A third embodiment of the present invention will now be explained.", "In the third embodiment, the electronic key 30 performs authentication with the smartphone 40 and transmits an automatic driving instruction signal, where the controller 38 of the electronic key 30 performs a process shown in FIG.", "13 periodically.", "The controller 38 of the electronic key 30 includes a primary authentication unit 38a and a transmit processing unit 38b.", "The primary authentication unit 38a of the electronic key 30 is responsible for execution of steps S51-S56, and the transmit processing unit 38b of the electronic key 30 is responsible for execution of step S57.In step S51, it is determined whether or not the automatic driving switch 35c has been pressed.", "If it is determined that the automatic driving switch 35c has not been pressed, then the process of FIG.", "13 ends.", "If it is determined that the automatic driving switch 35c has been pressed, then the process proceeds to step S52.In step S52, the electronic key 30 communicates with the smartphone 40 to perform the authentication, where it is determined whether or not the electronic key 30 and the smartphone 40 have been pre-registered with each other.", "This authentication may be performed beforehand as in step S12.In step S53, it is determined whether or not the authentication has succeeded.", "If it is determined that the authentication has failed, the process of FIG.", "13 ends.", "If it is determined that the authentication has succeeded, then the process proceeds to step S54.In step S54, a current location of the electronic key 30 is acquired.", "The current location of the electronic key 30 may be acquired from the GNSS receiver 34 of the electronic key 30 or from the smartphone 40.In the configuration where the current location of the electronic key 30 is acquired from the smartphone 40, the GNSS receiver 34 may be removed from the electronic key 30.In step S55, a distance between the electronic key 30 and the smartphone 40 is calculated.", "For example, the distance between the electronic key 30 and the smartphone 40 may be calculated based on the strength of a radio wave transmitted by the near field communication unit 47 of the smartphone 40 and then received by the near field communication unit 33 of the electronic key 30.Alternatively, the distance between the electronic key 30 and the smartphone 40 may be calculated from the current locations detected by the GNSS receivers 34, 41 of the electronic key 30 and the smartphone 40.In step S56, it is determined whether or not the distance calculated in step S55 is equal to or less than the mobile distance (being the same as defined in the first embodiment).", "Alternatively, as in the first embodiment, step S55 may be skipped, and in step S56, it may be determined whether or not the distance between the electronic key 30 and the smartphone 40 is equal to or less than the mobile distance by comparing the strength of the received radio wave with a predetermined threshold.", "If in step S56 it is determined that the distance between the electronic key 30 and the smartphone 40 is greater than the mobile distance, then the process ends.", "If in step S56 it is determined that the distance between the electronic key 30 and the smartphone 40 is equal to or less than the mobile distance, then the process of FIG.", "13 proceeds to step S57.In step S57, an automatic driving instruction signal (as an authentication signal) including the current location acquired in step S54 and a code used to authenticate the electronic key 30 is transmitted from the near field communication unit 47 or from the UHF transmitter 32 to the vehicle-mounted system 100.In the second embodiment, as in the first embodiment, the vehicle-mounted system 100 performs the process of FIG.", "8 to determine whether to allow automatic driving.", "An allowance or disallowance notification may be transmitted to the electronic key 30 or the smartphone 40.When the disallowance notification is transmitted to the electronic key 30, an indication that automatic driving has been disallowed is displayed on display 36.Meanwhile, after automatic driving is started, the process of FIG.", "10 is performed.", "Fourth Embodiment A fourth embodiment of the present invention will now be explained.", "In the fourth embodiment, the controller 38 of the electronic key 30 performs a process shown in FIG.", "14 periodically.", "In the fourth embodiment, the electronic key 30 serves as a primary communication device, and the smartphone 40 serves as a secondary communication device.", "In step S61, it is determined whether or not the automatic driving switch 35c has been pressed.", "If it is determined that the automatic driving switch 35c has not been pressed, then the process of FIG.", "14 ends.", "If it is determined that the automatic driving switch 35c has been pressed, then the process of FIG.", "14 proceeds to step S62.In step S62, an automatic driving instruction signal is transmitted from the UHF transmitter 32 of the electronic key 30.The automatic driving instruction signal includes a signal indicative of automatic driving, and further includes a code used to authenticate the electronic key 30 as included in a signal transmitted from an electronic key of a well-known electronic key system.", "Therefore, the automatic driving instruction signal serves as an authentication signal.", "In the fourth embodiment, the automatic driving instruction signal includes no current location of the electronic key 30.When the signal transmitted by the UHF transmitter 32 is the automatic driving instruction signal, the automatic driving instruction signal may have higher transmission power with a longer communication distance as compared with when the signal transmitted by the UHF transmitter 32 is a signal indicative of locking or unlocking of vehicle doors.", "The authentication unit 131 of the controller 130 of the vehicle-mounted system 100 performs a process shown in FIG.", "15 periodically.", "In step S71, it is determined whether or not automatic driving instruction signal transmitted from the electronic key 30 has been received by the first near field communication unit 115.If it is determined that the automatic driving instruction signal has not been received by the first near field communication unit 115, then the process of FIG.", "15 ends.", "If it is determined that the automatic driving instruction signal has been received by the first near field communication unit 115, then the process proceeds to step S72.In step S72, a confirmation signal is transmitted to the registered smartphone 40 to confirm whether or not the automatic driving instruction signal has been transmitted by a normal user 3.When the confirmation signal is received by the smartphone 40 and the start instruction button is pressed, a response signal is transmitted from the smartphone 40.In step S73, it is determined whether or not the response signal transmitted from the registered smartphone 40 has been received by the second near field communication unit 116.In the fourth embodiment, the first near field communication unit 115 and the second near field communication unit 116 serves as a receiver.", "If in step S73 it is determined that the response signal transmitted from the registered smartphone 40 has been received by the second near field communication unit 116, it can be considered that the authentication between the electronic key 30 and the smartphone 40 has succeeded.", "Then, the process proceeds to step S25 of FIG.", "8.If in step S73 it is determined that the response signal transmitted from the registered smartphone 40 has not been received by the second near field communication unit 116, the process proceeds to step S74.In step S74, it is determined whether or not a predetermined wait time has elapsed since the transmission of the confirmation signal.", "If in step S74 it is determined that the predetermined wait time has not elapsed yet since the transmission of the confirmation signal, the process returns to step S73.If in step S74 it is determined that the predetermined wait time has elapsed since the transmission of the confirmation signal, the process of FIG.", "15 ends.", "The controller 48 of the smartphone 40 performs a process shown in FIG.", "16 periodically while the automatic driving application 43a is activated.", "The automatic driving application 43a may be a resident application or a user-activated application.", "In step S81, it is determined whether or not the confirmation signal transmitted from the vehicle-mounted system 100 in step S72 of FIG.", "15 has been received.", "If in step S81 it is determined that the confirmation signal has not been received, then the process of FIG.", "16 ends.", "If in step S81 it is determined that the confirmation signal has been received, then the process of FIG.", "16 proceeds to step S82.In step S82, a start instruction button is displayed on the display 45.In step S83, it is determined whether or not the start instruction button has been operated.", "If it is determined that the start instruction button has not been operated, then the process proceeds to step S84.In step S84, it is determined whether or not a predetermined wait time has elapsed since the receipt of the confirmation signal.", "If it is determined that the predetermined wait time has not elapsed yet since the receipt of the confirmation signal, then the process returns to step S83.If it is determined that the predetermined wait time has elapsed since the receipt of the confirmation signal, then the process of FIG.", "16 proceeds to step S85.In step S85, a current location of the smartphone 40 is acquired from the GNSS receiver 41.In step S86, a response signal including the current location acquired in step S85 is transmitted from the near field communication unit 47 to the vehicle-mounted system 100.As described above, in step S73, it is determined that the response signal has been received by the vehicle-mounted system 100.", "(Advantages) In the fourth embodiment, the electronic key 30 is configured to transmit the automatic driving instruction signal via the UHF transmitter 32 and the automatic driving instruction signal does not include the current location of the electronic key 30.The UHF transmitter 32 may be included in an electronic key of a well-known electronic key system.", "Therefore, in the fourth embodiment, the electronic key 30 may have a small change in configuration from the electronic key of the well-known electronic key system.", "In the fourth embodiment, the electronic key 30 is configured such that the automatic driving instruction signal has higher transmission power as compared with a signal indicative of locking or unlocking of vehicle doors.", "Therefore, in the fourth embodiment, the electronic key 30 may have a smaller change in configuration from the electronic key of the well-known electronic key system as compared with an electronic key provided with an additional communication unit operable in a different communication scheme based on a different frequency band different from the UHF band.", "In addition, automatic driving can be started only when the vehicle-mounted system 100 receives the response signal transmitted by the registered smartphone 40 in response to the confirmation signal from the vehicle-mounted system 100.This can increases the security of the system.", "(Modifications) It is to be understood that the invention is not to be limited to the specific embodiment disclosed above and that modifications and other embodiments are intended to be included within the scope of the appended claims.", "(First Modification) In each of the first to fourth embodiments, the controller 130 of the vehicle-mounted system 100 includes the automatic-driving control unit 133 as an activation unit.", "The allowance determination unit 132 is configured to allow operation of the activation unit.", "Alternatively, the activation unit may be a door lock unit to lock or unlock the vehicle doors, an engine control unit to start the engine of the vehicle, or a program updater to update a program of a controller mounted in the vehicle.", "(Second Modification) In each of the first and second embodiments, during automatic driving, the vehicle-mounted system 100 establishes the communication with the smartphone 40 and then sequentially transmits the driving condition signal to the smartphone 40.If the communication is interrupted, the automatic-driving control unit 133 may halt automatic driving.", "When automatic driving is halted, the automatically driven vehicle 2 is stopped.", "Preferably, if the communication with the vehicle-mounted system 100 is interrupted during automatic driving, the smartphone 40 may display on the display 45 an indication that automatic driving has been halted.", "(Third Modification) The electronic key 30 and the smartphone 40 may be each provided with an infrared communication unit and/or a near field communication unit for communicating with each other.", "(Fourth Modification) In each of the first to fourth embodiments, the smartphone 40 and the vehicle-mounted system 100 communicate directly with each other, and the electronic key 30 and the vehicle-mounted system 100 communicate directly with each other.", "Alternatively, the smartphone 40 and the vehicle-mounted system 100 may communicate indirectly with each other via the central server 20 or the parking lot monitor 10.The electronic key 30 and the vehicle-mounted system 100 may communicate indirectly with each other via the parking lot monitor 10 or the smartphone 40.", "(Fifth Modification) In a modification to the fourth embodiment, the process performed in the electronic key 30 (steps S61-S62 of FIG.", "14) and the process performed in the smartphone 40 (steps S81 to S86 of FIG.", "16) may be exchanged.", "In such a modification, the smartphone 40 serves as a primary communication device, and the electronic key 30 serves as a secondary communication device." ] ]
Patent_15872720
[ [ "Autonomous Unmanned Road Vehicle for Making Deliveries", "An autonomous unmanned road vehicle and how it can be used to make deliveries.", "The unmanned vehicle is capable of operating autonomously on paved roadways.", "The vehicle has a control system for autonomous driving and a perception system for detecting objects in its surroundings.", "The vehicle also has one or more cargo compartments for carrying the delivery items.", "The vehicle may have a flashing light beacon to increase the conspicuousness of the vehicle.", "In consideration that the vehicle does not carry passengers, the size and/or motor power of the vehicle may be reduced as compared to conventional passenger vehicles." ], [ "1.A method of transporting an item from a sender to a recipient using an autonomous unmanned road vehicle that comprises a cargo compartment but does not have any passenger seats, the method comprising: receiving from the sender, a request for transporting an item from a location designated by the sender to a location designated by the recipient, wherein the request includes the recipient's contact information; from a fleet of multiple autonomous unmanned road vehicles, assigning a vehicle for transporting the item; driving the assigned vehicle, at least partly in an autonomous manner, to the sender's designated location via a paved roadway; receiving into the cargo compartment, an item to be sent to the recipient; driving the assigned vehicle, at least partly in an autonomous manner, to the recipient's designated location; notifying the recipient that the assigned vehicle is on its way or has arrived.", "2.The transportation method of claim 1, wherein the fleet of vehicles operates from a home base facility.", "3.The transportation method of claim 2, wherein the assigned vehicle travels within an operating area that is within a 15 miles radius around the home base facility.", "4.The transportation method of claim 2, wherein the home base facility is located in an area that is zoned for commercial, industrial, or mixed residential-commercial use.", "5.The transportation method of claim 4, wherein the home base facility is located within 6 miles from a residential area, or area that is zoned for residential use, or a residential building.", "6.The transportation method of claim 2, wherein the home base facility is located within 6 miles from a residential area, or area that is zoned for residential use, or a residential building.", "7.The transportation method of claim 2, wherein the home base facility has a recovery truck.", "8.The transportation method of claim 7, wherein the home base facility has a covered garage for vehicle storage.", "9.The transportation method of claim 2, wherein the home base facility has a covered garage for vehicle storage.", "10.The transportation method of claim 2, wherein the transportation method is implemented in a delivery service and the home base facility is dedicated solely for the delivery service.", "11.The transportation method of claim 2, wherein the transportation method is implemented in a delivery service and the home base facility is located at a business facility that operates a different type of business, other than the delivery service.", "12.The transportation method of claim 2, wherein the home base facility has personnel and equipment for maintaining the fleet of vehicles.", "13.The transportation method of claim 12, wherein the home base facility has a recovery truck.", "14.The transportation method of claim 1, wherein the assigned vehicle comprises radio communications equipment, and further comprising remotely monitoring the assigned vehicle through its radio communications equipment while driving the assigned vehicle.", "15.The transportation method of claim 14, wherein the driving of the assigned vehicle is performed by a combination of human control via remote operation and autonomous control.", "16.The transportation method of claim 1, further comprising, on a street at the recipient's designated location, parking the assigned vehicle such that access to the cargo compartment is not positioned on the side facing the street.", "17.The transportation method of claim 1, wherein the assigned vehicle is neither the sender's or the recipient's possession.", "18.The transportation method of claim 1, further comprising notifying the sender that the assigned vehicle is on its way or has arrived.", "19.The transportation method of claim 1, wherein the sender's request further includes information about the item being delivered.", "20.The transportation method of claim 15, wherein the assigned vehicle further comprises an external loudspeaker and an external microphone.", "21.The transportation method of claim 1, the assigned vehicle further comprises an external loudspeaker and an external microphone." ], [ "<SOH> BACKGROUND <EOH>In the transportation and logistics industry, the “last mile” problem refers to the delivery of goods to the final destination.", "There are many challenges to making delivery to the final destination.", "Some examples include theft of packages if they are left on the doorstep of the recipient's home, having to schedule a delivery time with the recipient, having to skip the delivery and return another day, leaving the package with an unreliable concierge or roommate, requiring the presence of the recipient at an inconvenient time, or requiring the recipient to travel to a special locker or other designated location to pickup their package.", "We propose using an autonomous unmanned road vehicle for an improved delivery service." ], [ "<SOH> SUMMARY <EOH>Our invention relates to autonomous unmanned road vehicles and how they can be used to make deliveries.", "In one embodiment, our invention is a method of transporting tangible goods.", "The method comprises loading multiple packages onto a transport vehicle at a regional distribution facility.", "The packages are destined for multiple delivery destinations that are designated by different postal addresses.", "The packages are transported to a local distribution facility via the transport vehicle.", "The recipients are notified that their packages are ready for delivery.", "After receiving a delivery request notification from a recipient, the package is loaded onto an autonomous unmanned ground vehicle.", "The unmanned ground vehicle is driven on a paved roadway to the recipient's delivery destination.", "The recipient is notified that their package has arrived or will be arriving.", "The package is then delivered to the recipient's delivery destination.", "In some embodiments, the method further comprises: sending an access code to the recipient for accessing the package; accepting the correct access code entered by the recipient; and allowing access to the package.", "Another method for transporting tangible goods comprises loading multiple packages onto an autonomous unmanned ground vehicle for delivery to multiple delivery destinations that are designated by different postal addresses.", "The unmanned vehicle is driven on a paved roadway to a waiting area.", "At least 85% of the delivery destinations are within a 6 mile radius of the waiting area.", "The recipients are notified that their packages are ready for delivery.", "After receiving a delivery request notification from a recipient of a package, the vehicle is driven to the recipient's delivery destination.", "The recipient is notified that their package has arrived or will be arriving.", "The package is delivered at the recipient's delivery destination.", "The vehicle may then return to the same waiting area or go to a different waiting area.", "In some embodiments, the method further comprises: sending an access code to the recipient for accessing the package; accepting the correct access code entered by the recipient; and allowing access to the package.", "Another embodiment of our invention is a system for delivering tangible goods.", "The system comprises a regional distribution facility and a local distribution facility that receives packages from the regional distribution facility.", "The packages received by the local distribution facility are destined for multiple delivery destinations that are designated by different postal addresses.", "The system further comprises an autonomous unmanned ground vehicle for delivering the packages to the delivery destinations and an operations hub having equipment to communicate with the unmanned vehicle and the recipients of the packages.", "In another embodiment, the system comprises: a distribution facility that receives packages that are destined for multiple delivery destinations that are designated by different postal addresses; an autonomous unmanned ground vehicle for delivering the packages to the delivery destinations; an operations hub having equipment to communicate with the unmanned vehicle and the recipients of the packages; and a waiting area where the unmanned ground vehicle can park while awaiting a delivery request.", "Another embodiment of our invention is a method of transporting packages that are destined for multiple delivery destinations using an autonomous unmanned ground vehicle.", "The packages are transported from a first location to a second (intermediate) location.", "The recipients of the packages are notified that their packages are ready for delivery.", "After receiving a delivery request notification from a recipient of a package, the unmanned ground vehicle that is loaded with the recipient's package is driven from the intermediate location to the recipient's delivery destination.", "The recipient is notified that their package has arrived or will be arriving.", "After delivering the package, the vehicle is driven back to the intermediate location.", "Another embodiment of our invention is a method of delivering retail goods to customers on-demand.", "The method comprises receiving a purchase order from a customer for delivery to a delivery destination (the purchase order comprising a purchased item).", "At a local retail facility located within a 6 mile radius of the delivery destination, the purchased item is put into delivery packaging.", "A message is sent to the customer that their purchase order is ready for delivery.", "The customer's delivery request is received at a time after the purchase order is received.", "After receiving this delivery request, the delivery packaging containing the customer's purchased item is loaded into an autonomous unmanned ground vehicle, which is driven to the customer's delivery destination.", "The customer is notified that their purchase order has arrived or will be arriving.", "The purchased item is delivered at the customer's delivery destination.", "In some cases, the purchase order includes a cold food item that is put into a separate delivery packaging.", "In some cases, while awaiting the delivery request, the delivery packaging holding the cold food item is kept in a refrigerated space at the local retail facility.", "In some cases, the vehicle has a cold compartment that is thermally insulated and/or cooled, and the container holding the cold food item is loaded into the cold compartment.", "In some cases, the container for the cold food item is reusable, and after making the delivery, the vehicle stands by and waits until the container is returned to the vehicle, and departs afterwards.", "In some cases, the purchased item is held in a cargo compartment in the unmanned ground vehicle, and the method further comprises: sending an access code to the customer for accessing the cargo compartment; accepting the entry of a correct access code; and allowing access to the cargo compartment.", "Another embodiment of our invention is a delivery system for delivering retail goods to customers.", "The system comprises a local retail facility that has an inventory of retail goods and is located within a 6 mile radius of the customers' residences.", "The delivery system further comprises a computer system for receiving purchase orders of retail goods from customers and an autonomous unmanned ground vehicle for delivering the purchase orders to the customers' residences.", "The delivery system further comprises an operations hub having equipment to communicate with the unmanned vehicle and the customers.", "In some cases, the local retail facility operates both as a walk-in retail store and a delivery service of retail goods.", "In some cases, the delivery service is operated out of one or more back rooms/areas of the local retail facility.", "Another embodiment of our invention is another method for transporting tangible goods.", "The method uses a home base facility that has a fleet of autonomous unmanned ground vehicles.", "After receiving a request from a sender for delivery of an item from the sender's designated location to a recipient at the recipient's location, an unmanned vehicle is selected for the sender's request.", "The selected vehicle may or may not be located at the home base facility.", "The unmanned ground vehicle is driven to the sender's designated location.", "The sender is notified that the unmanned ground vehicle has arrived or will be arriving.", "At the sender's designated location, the item is received into the unmanned ground vehicle.", "The unmanned ground vehicle is driven to the recipient's location.", "The recipient is notified that the unmanned ground vehicle has arrived or will be arriving.", "The item is delivered at the recipient's location.", "Another embodiment of our invention is another system for transporting tangible goods.", "The system comprises a fleet of autonomous unmanned ground vehicles and a home base facility where the unmanned ground vehicles are kept.", "The system further comprises an operations hub for coordinating the use of the unmanned ground vehicles.", "The unmanned ground vehicles operate only in an area that is contained within a 15 mile radius around the home base facility.", "Another embodiment of our invention is a method for transporting tangible goods over a regional area.", "The method uses a fleet of autonomous unmanned ground vehicles and multiple home base facilities that are geographically separated in an area contained within a circle having a radius of 64 miles.", "After receiving a request from a sender for delivery of an item from the sender's designated location to a recipient at the recipient's location, an unmanned vehicle is selected for the sender's request.", "The selected vehicle may or may not be located at a home base facility.", "The unmanned ground vehicle is driven to the sender's designated location.", "The sender is notified that the unmanned ground vehicle has arrived or will be arriving.", "At the sender's designated location, the item is received into the unmanned ground vehicle.", "The unmanned ground vehicle is driven to the recipient's location.", "The recipient is notified that the unmanned ground vehicle has arrived or will be arriving.", "The item is delivered at the recipient's location.", "The overall area in which the vehicle operates is contained within two or more adjoining or overlapping circles that each have a radius of 9 miles around a home base facility.", "Another embodiment of our invention is a system for transporting tangible goods over a regional area.", "The system comprises a fleet of autonomous unmanned ground vehicles and a network of multiple home base facilities geographically separated in an area contained within a circle having a radius of 64 miles.", "The system further comprises an operations hub for coordinating the use of the unmanned ground vehicles.", "The unmanned ground vehicles operate only in an area that is contained within two or more adjoining or overlapping circles that each have a radius of 9 miles around a home base facility." ], [ "RELATED APPLICATIONS This application claims the benefit of U.S.", "Provisional Applications Ser.", "No.", "61/841,912 (filed 1 Jul.", "2013), No.", "61/893,281 (filed 20 Oct. 2013), No.", "61/909,227 (filed 26 Nov. 2013), No.", "61/916,261 (filed 15 Dec. 2013), No.", "61/921,464 (filed 28 Dec. 2013), and No.", "61/970,881 (filed 26 Mar.", "2014), all of which are incorporated by reference herein.", "TECHNICAL FIELD Our invention relates to using autonomous (e.g.", "driverless or self-driving) vehicles for making deliveries.", "BACKGROUND In the transportation and logistics industry, the “last mile” problem refers to the delivery of goods to the final destination.", "There are many challenges to making delivery to the final destination.", "Some examples include theft of packages if they are left on the doorstep of the recipient's home, having to schedule a delivery time with the recipient, having to skip the delivery and return another day, leaving the package with an unreliable concierge or roommate, requiring the presence of the recipient at an inconvenient time, or requiring the recipient to travel to a special locker or other designated location to pickup their package.", "We propose using an autonomous unmanned road vehicle for an improved delivery service.", "SUMMARY Our invention relates to autonomous unmanned road vehicles and how they can be used to make deliveries.", "In one embodiment, our invention is a method of transporting tangible goods.", "The method comprises loading multiple packages onto a transport vehicle at a regional distribution facility.", "The packages are destined for multiple delivery destinations that are designated by different postal addresses.", "The packages are transported to a local distribution facility via the transport vehicle.", "The recipients are notified that their packages are ready for delivery.", "After receiving a delivery request notification from a recipient, the package is loaded onto an autonomous unmanned ground vehicle.", "The unmanned ground vehicle is driven on a paved roadway to the recipient's delivery destination.", "The recipient is notified that their package has arrived or will be arriving.", "The package is then delivered to the recipient's delivery destination.", "In some embodiments, the method further comprises: sending an access code to the recipient for accessing the package; accepting the correct access code entered by the recipient; and allowing access to the package.", "Another method for transporting tangible goods comprises loading multiple packages onto an autonomous unmanned ground vehicle for delivery to multiple delivery destinations that are designated by different postal addresses.", "The unmanned vehicle is driven on a paved roadway to a waiting area.", "At least 85% of the delivery destinations are within a 6 mile radius of the waiting area.", "The recipients are notified that their packages are ready for delivery.", "After receiving a delivery request notification from a recipient of a package, the vehicle is driven to the recipient's delivery destination.", "The recipient is notified that their package has arrived or will be arriving.", "The package is delivered at the recipient's delivery destination.", "The vehicle may then return to the same waiting area or go to a different waiting area.", "In some embodiments, the method further comprises: sending an access code to the recipient for accessing the package; accepting the correct access code entered by the recipient; and allowing access to the package.", "Another embodiment of our invention is a system for delivering tangible goods.", "The system comprises a regional distribution facility and a local distribution facility that receives packages from the regional distribution facility.", "The packages received by the local distribution facility are destined for multiple delivery destinations that are designated by different postal addresses.", "The system further comprises an autonomous unmanned ground vehicle for delivering the packages to the delivery destinations and an operations hub having equipment to communicate with the unmanned vehicle and the recipients of the packages.", "In another embodiment, the system comprises: a distribution facility that receives packages that are destined for multiple delivery destinations that are designated by different postal addresses; an autonomous unmanned ground vehicle for delivering the packages to the delivery destinations; an operations hub having equipment to communicate with the unmanned vehicle and the recipients of the packages; and a waiting area where the unmanned ground vehicle can park while awaiting a delivery request.", "Another embodiment of our invention is a method of transporting packages that are destined for multiple delivery destinations using an autonomous unmanned ground vehicle.", "The packages are transported from a first location to a second (intermediate) location.", "The recipients of the packages are notified that their packages are ready for delivery.", "After receiving a delivery request notification from a recipient of a package, the unmanned ground vehicle that is loaded with the recipient's package is driven from the intermediate location to the recipient's delivery destination.", "The recipient is notified that their package has arrived or will be arriving.", "After delivering the package, the vehicle is driven back to the intermediate location.", "Another embodiment of our invention is a method of delivering retail goods to customers on-demand.", "The method comprises receiving a purchase order from a customer for delivery to a delivery destination (the purchase order comprising a purchased item).", "At a local retail facility located within a 6 mile radius of the delivery destination, the purchased item is put into delivery packaging.", "A message is sent to the customer that their purchase order is ready for delivery.", "The customer's delivery request is received at a time after the purchase order is received.", "After receiving this delivery request, the delivery packaging containing the customer's purchased item is loaded into an autonomous unmanned ground vehicle, which is driven to the customer's delivery destination.", "The customer is notified that their purchase order has arrived or will be arriving.", "The purchased item is delivered at the customer's delivery destination.", "In some cases, the purchase order includes a cold food item that is put into a separate delivery packaging.", "In some cases, while awaiting the delivery request, the delivery packaging holding the cold food item is kept in a refrigerated space at the local retail facility.", "In some cases, the vehicle has a cold compartment that is thermally insulated and/or cooled, and the container holding the cold food item is loaded into the cold compartment.", "In some cases, the container for the cold food item is reusable, and after making the delivery, the vehicle stands by and waits until the container is returned to the vehicle, and departs afterwards.", "In some cases, the purchased item is held in a cargo compartment in the unmanned ground vehicle, and the method further comprises: sending an access code to the customer for accessing the cargo compartment; accepting the entry of a correct access code; and allowing access to the cargo compartment.", "Another embodiment of our invention is a delivery system for delivering retail goods to customers.", "The system comprises a local retail facility that has an inventory of retail goods and is located within a 6 mile radius of the customers' residences.", "The delivery system further comprises a computer system for receiving purchase orders of retail goods from customers and an autonomous unmanned ground vehicle for delivering the purchase orders to the customers' residences.", "The delivery system further comprises an operations hub having equipment to communicate with the unmanned vehicle and the customers.", "In some cases, the local retail facility operates both as a walk-in retail store and a delivery service of retail goods.", "In some cases, the delivery service is operated out of one or more back rooms/areas of the local retail facility.", "Another embodiment of our invention is another method for transporting tangible goods.", "The method uses a home base facility that has a fleet of autonomous unmanned ground vehicles.", "After receiving a request from a sender for delivery of an item from the sender's designated location to a recipient at the recipient's location, an unmanned vehicle is selected for the sender's request.", "The selected vehicle may or may not be located at the home base facility.", "The unmanned ground vehicle is driven to the sender's designated location.", "The sender is notified that the unmanned ground vehicle has arrived or will be arriving.", "At the sender's designated location, the item is received into the unmanned ground vehicle.", "The unmanned ground vehicle is driven to the recipient's location.", "The recipient is notified that the unmanned ground vehicle has arrived or will be arriving.", "The item is delivered at the recipient's location.", "Another embodiment of our invention is another system for transporting tangible goods.", "The system comprises a fleet of autonomous unmanned ground vehicles and a home base facility where the unmanned ground vehicles are kept.", "The system further comprises an operations hub for coordinating the use of the unmanned ground vehicles.", "The unmanned ground vehicles operate only in an area that is contained within a 15 mile radius around the home base facility.", "Another embodiment of our invention is a method for transporting tangible goods over a regional area.", "The method uses a fleet of autonomous unmanned ground vehicles and multiple home base facilities that are geographically separated in an area contained within a circle having a radius of 64 miles.", "After receiving a request from a sender for delivery of an item from the sender's designated location to a recipient at the recipient's location, an unmanned vehicle is selected for the sender's request.", "The selected vehicle may or may not be located at a home base facility.", "The unmanned ground vehicle is driven to the sender's designated location.", "The sender is notified that the unmanned ground vehicle has arrived or will be arriving.", "At the sender's designated location, the item is received into the unmanned ground vehicle.", "The unmanned ground vehicle is driven to the recipient's location.", "The recipient is notified that the unmanned ground vehicle has arrived or will be arriving.", "The item is delivered at the recipient's location.", "The overall area in which the vehicle operates is contained within two or more adjoining or overlapping circles that each have a radius of 9 miles around a home base facility.", "Another embodiment of our invention is a system for transporting tangible goods over a regional area.", "The system comprises a fleet of autonomous unmanned ground vehicles and a network of multiple home base facilities geographically separated in an area contained within a circle having a radius of 64 miles.", "The system further comprises an operations hub for coordinating the use of the unmanned ground vehicles.", "The unmanned ground vehicles operate only in an area that is contained within two or more adjoining or overlapping circles that each have a radius of 9 miles around a home base facility.", "BRIEF DESCRIPTION OF THE DRAWINGS FIGS.", "1A-1C show different views of an autonomous unmanned road vehicle as an example of our invention.", "FIG.", "2A shows a lidar apparatus in operating mode when the vehicle is traveling.", "FIG.", "2B shows the lidar apparatus in protected mode inside of a metal shield when the vehicle is parked.", "FIG.", "3A shows a lidar apparatus in operating mode when the vehicle is traveling.", "FIG.", "3B shows the lidar apparatus lowered into the mounting base and body of the vehicle when the vehicle is parked.", "FIG.", "4A shows a side view of a light beacon and perception apparatus integrated into a rotating cylinder; FIG.", "4B shows an overhead view.", "FIG.", "5A shows a front view of a perception apparatus mounted on a stalk such that the sensor eye is elevated above the level of the flashing light beacon; FIG.", "5B shows an overhead view.", "FIG.", "6 shows an example of how an autonomous unmanned road vehicle can be used to make deliveries from a distribution facility.", "FIG.", "7 shows another example of how an autonomous unmanned road vehicle can be used to make deliveries from a distribution facility and waiting area.", "FIGS.", "8-10 show an example of how an autonomous unmanned road vehicle can be used to make deliveries from a supermarket store.", "FIGS.", "8 and 9 show different views of the back of the supermarket store.", "FIG.", "10 shows the delivery vehicle loaded with a customer order.", "FIG.", "11 shows examples of how operating areas may appear in regards to shape.", "FIG.", "12 shows an example of how an autonomous unmanned road vehicle can be used to make deliveries from a home base facility.", "FIG.", "13 shows another example of an operating area for an autonomous unmanned road vehicle in a regional delivery network.", "FIG.", "14 shows an example of a regional delivery network.", "DETAILED DESCRIPTION Our invention contemplates the use of the unmanned ground vehicle for transporting tangible goods, such as packages, retail goods, or other items.", "An example of the unmanned ground vehicle is shown in FIGS.", "1A-1C, which will be explained in further detail below.", "The unmanned vehicle is designed to be capable of operating autonomously (e.g.", "navigating and driving) on paved roadways (e.g.", "paved with asphalt, concrete, or composites) that are ordinarily used for motor vehicle traffic.", "Examples of paved roadways include streets, roads, highways, freeways, avenues, boulevards, bridges, tunnels, etc.", "The paved roadways may be public or private.", "The paved roadways may have traffic lanes, pavement markings, traffic signals or traffic signs, speed limits, median dividers between opposite-direction traffic, or other typical features of roadways.", "The paved roadways may be designated with identifying names (e.g.", "Main Street) or numbers (e.g.", "Route 101) by a government authority (e.g.", "municipal government).", "For operating on paved roadways, the autonomous driving capabilities of the unmanned vehicle may include obeying traffic signals and/or signs; obeying speed limits; making turns at intersections; observing pavement line markings and staying within travel lanes; changing lanes; avoiding other vehicles on the roadway and maintaining a safe distance with the vehicle ahead; avoiding pedestrians and stopping for pedestrians crossing the roadway or school buses; giving signals (e.g.", "braking light, turn signal, etc.)", "to other vehicles or other drivers; reducing speed for shopping centers, parking lots, downtown areas, vicinity of schools, vicinity of playgrounds, in vicinity of pedestrians, and/or residential roadways; parking in designated areas or according to parking rules or regulations; entering and exiting limited access highways (e.g.", "interstate highways), and/or other such capabilities.", "The vehicle's control system may include a navigation system that is capable of autonomously driving the vehicle to specific coordinates, landmarks, or street address locations (e.g.", "1250 Main Street, Anytown, Mass.", "90210, a fictitious address).", "The vehicle's navigation system may use a map that, in addition to the conventional roadway and navigational information, further contains specific information about traffic or roadway infrastructure features.", "Examples of such specific information include location of off-site parking spaces; location of curbside parking spaces; which lanes to use during travel or making turns; locations and orientations of traffic signals (such as signal lights and stop signs); speed limits; location of residential, commercial, and/or industrial areas; traffic patterns; road conditions such as the location speed bumps or potholes; location of intersections; location of pedestrian crossings and areas frequented by pedestrians; location of road construction sites, etc.", "In addition to location information, other types of information that may be associated include timing, orientation, tolls/fees, times of availability, etc.", "This information may be acquired in any suitable manner, such as by additional pre-navigation and mapping of the area in which the vehicle will be operated.", "Perception System The vehicle has a computer control system for its autonomous driving capability and has a perception system for detecting objects in its surroundings.", "The “perception system” includes a perception apparatus to collect image information and other components for processing the image information, such as associated computer hardware and software.", "The “perception apparatus” includes the sensor eye and other associated components, such as sensors, detectors, emitters (e.g.", "radio, conventional light, laser), drive motors and mechanical parts, mirrors, etc.", "Examples of perception apparatus include cameras, lidar, radar, sonar, etc.", "The sensor eye is the part of the perception apparatus where it directly receives its “point-of-view” of the environment (e.g.", "the opening, lens, or window through which light enters the perception apparatus).", "The perception apparatus may use any of various types of sensors, including photodetectors (e.g.", "in a camera or lidar), radar receiver, or sonar receiver.", "The vehicle's perception system may use a single or multiple different modalities.", "In some embodiments, the perception apparatus uses a photodetector, such as an optical image sensor in a camera or photodiodes in a lidar.", "The perception apparatus may be one of the more expensive components of the vehicle.", "Moreover, the perception apparatus may be vulnerable to potentially damaging external forces, such as vandalism, weather conditions, debris, etc.", "Thus, in some embodiments, the perception apparatus may be enclosed in a protective housing that is at least partially transparent, such as a polycarbonate or poly(methyl-methacrylate) dome.", "In some embodiments, the perception apparatus can be put into a protected mode in which it is shielded or otherwise protected from these potentially damaging external forces.", "The perception apparatus can be put into the protected mode in appropriate circumstances such as when the vehicle is not driving, when a threat is detected, when parked, when under attack, when the vehicle is disabled, etc.", "The perception apparatus can be switched from the operational mode to the protected mode and vice versa.", "This protected mode can be provided by any suitable mechanism such as a shield being raised around the perception apparatus or it being retracted into an internal part of the vehicle.", "For example, FIG.", "2A shows the lidar apparatus 50 (with sensor eye 52 and mounted on a stalk 54) in operating mode when the vehicle is driving.", "But as shown in FIG.", "2B, when the vehicle is parked, the lidar apparatus 50 is put in protected mode with a metal shield 56 being raised around the lidar apparatus 50.In another example, FIGS.", "3A and 3B show the lidar apparatus 50 put into protected mode by retracting it into the mounting base 58 and the body of the vehicle when parked.", "We consider that this particular feature of the perception apparatus having a protected mode can be used with any autonomous ground vehicle, such as self-driving passenger vehicles, and not necessarily limited to the passengerless delivery vehicles described herein.", "Light Beacon In some embodiments, the vehicle has a flashing light beacon (e.g.", "on the roof of the vehicle) that operates while traveling on a roadway.", "This may be useful to increase the conspicuousness of the vehicle.", "The flashing may be produced in any suitable manner, including electrically-produced (e.g.", "strobing as a burst-like flash or pulsing) or mechanically-produced (e.g.", "rotating light beam or reflective shield).", "Since the unmanned vehicle does not pose a danger to anyone, the light beacon may be designed to operate in a manner that avoids causing annoyance, distraction, alarm, fright, or sense of potential danger or urgency, such as causing other drivers to pull over to the side of the road or causing pedestrians to be afraid of crossing the street when an unmanned vehicle approaches.", "This can be achieved by using a slower flash rate, lower luminous intensity, selecting the color of the light, selecting the type of flashing, or reducing the number of flashing lamps in the light beacon.", "In some embodiments, none of the light beacon(s) on the vehicle produce a strobing-type flash, which can be unnecessarily annoying, distracting, or alarming to people.", "In some embodiments, only mechanically-produced flashing is used for light beacon(s) on the vehicle.", "In some embodiments, no strobing-type flashing is used for any light beacon(s) on the vehicle.", "In some embodiments, the flash rate of the light beacon is relatively slow.", "In some cases, the flash rate of the light beacon is slower than 120 per minute; in some cases, slower than 105 per minute; in some cases, slower than 90 per minute; in some cases, slower than 75 per minute; in some cases, slower than 60 per minute; in some cases, slower than 45 per minute.", "As used herein, “flash rate” means the rate as discerned by ordinary, unassisted human perception.", "For example, some conventional warning lights emit double flashes or quad flashes (i.e.", "two quick flashes or four quick flashes that are perceived as a single flash).", "In such a case, each double flash or quad flash would be counted as a single flash.", "The light beacon may have one or more flashing lamps.", "If the light beacon has multiple flashing lamps, in some cases, the lamps may flash synchronously, alternately, or some other pattern.", "If the light beacon has multiple flashing lamps, in some cases, the multiple lamps flash only in an alternating pattern.", "In some cases, the light beacon has only a single or at most two flashing lamps.", "This may be useful because having too many flashing lamps can be unnecessarily annoying, distracting, or alarming to people.", "In some embodiments, each flash of the light beacon has relatively lower luminous intensity (candela) than beacons used on emergency or hazard vehicles.", "In some cases, the light beacon is designed to operate such that each flash has a luminous intensity of less than 800 cd (candela) in full daylight conditions; in some cases, less than 600 cd; in some cases, less than 500 cd; and in some cases, less than 400 cd.", "This feature does not exclude the possibility that there may be other intensities used for operating in other or intermediate lighting conditions, such as night, dawn/dusk, rain, fog, etc.", "The luminous intensity can be measured using conventional instruments such as a photometer.", "For the light beacon, it may be desirable to avoid colors that are associated with emergencies or hazard vehicles.", "In some embodiments, the vehicle has one or more light beacons, but none are blue.", "In some embodiments, the vehicle has one or more light beacons, but none are red.", "In some embodiments, the vehicle has one or more light beacons, but none are amber.", "Combinations of the preceding are also possible (e.g.", "not blue nor red).", "In some embodiments, the light beacon uses only non-emergency colors, such as white, amber, yellow, yellow-orange, orange, green, green-yellow, purple, or violet.", "In order to avoid interfering with the perception system, in some embodiments, the light spectrum emitted by the light beacon is different from the light spectrum emitted (if it does so) by the perception apparatus.", "In order to avoid interfering with the perception apparatus, in some embodiments, the light beacon may be positioned at an elevation that is different from the sensor eye of the perception apparatus.", "For example, the light beacon may be positioned at an elevation above or below that of the sensor eye.", "Setting the sensor eye of the perception apparatus at an elevation higher than the light beacon can improve the field of perception, especially if the vehicle has a relatively lower height.", "In some embodiments, the light beacon and the perception apparatus are mounted above or below each other with at least some part of the perception apparatus vertically overlapping with at least some part of the light beacon.", "For example, FIG.", "5A shows the perception apparatus 50 mounted on a stalk 54 such that the sensor eye 52 is elevated above the level of the flashing light beacon 34.Moreover, as shown in FIG.", "5B, there is vertical overlap of the perception apparatus 50 and the flashing light beacon 34 from the overhead view.", "In some cases, both the light beacon and the perception apparatus are mounted on the same upwardly protruding structure on top of the vehicle (e.g.", "on a stalk or mounting base).", "In some cases, both the light beacon and the perception apparatus are positioned on the same vertically-extending axis.", "In some cases, both the light beacon and the perception apparatus are made to spin on the same vertically-extending axis.", "In such cases, the light beacon and the perception apparatus may rotate synchronously.", "For example, FIGS.", "4A and 4B show the light beacon and perception apparatus being integrated into a rotating cylinder and housed within a protective glass dome 24.There are three lamps 32 on the cylinder that spins in the direction shown by the arrow.", "The sensor eye 22 (i.e.", "a window in the cylinder) of the perception apparatus is positioned between two of the lamps 32 and rotates together with the lamps 32.Vehicle Color & Graphics In some embodiments, at least some part of the vehicle is given a feminine color.", "This may be useful in deterring hostile physical actions (e.g.", "vandalism) against the vehicle.", "The term “feminine color” as used herein means a color that is generally considered by Americans to be more feminine than being masculine or neutral.", "This can be determined by a market research survery asking people whether they believe that a particular color is feminine, masculine, or neutral.", "The survey would be on a sample of adults in America who received their entire K-12 (kindergarten through grade 12) schooling in America, and the survey group composition being equally male and female in number.", "Examples of feminine colors include pink and pastel colors.", "The feminine color may be the predominant color of the vehicle (e.g.", "the base paint color) or may play a lesser role (e.g.", "part of the graphics).", "In some embodiments, the exterior of the vehicle displays an image of a female person (e.g.", "photo or illustration) or female character (e.g.", "cartoon drawing or figure, such as Tinker Bell).", "In some cases, the female person or character in the image is smiling.", "This may be useful in deterring hostile physical actions (e.g.", "vandalism) against the vehicle.", "In some embodiments, the vehicle has an anti-graffiti surface provided by a specialized anti-graffiti coating, paint, film, etc.", "Speed Limit Because the vehicle may have a relatively smaller size, relatively weaker motor power, and/or relatively more unstable aerodynamics, the vehicle may travel at a relatively slower speed as compared to conventional passenger cars.", "In some embodiments, the speed of the vehicle is limited to a maximum allowable speed V (e.g.", "having a speed governor), with V being a value of 65 mph or less (e.g.", "V=57 mph or V=48 mph); in some cases, V being a value of 60 mph or less; in some cases, V being a value of 55 mph or less; in some cases, V being a value of 50 mph or less; in some cases, V being a value of 45 mph or less.", "In some embodiments, the vehicle does not operate on roadways having a speed limit of 50 mph or greater; in some cases, on roadways having a speed limit of 55 mph or greater; in some cases, on roadways having a speed limit of 65 mph or greater (e.g.", "does not operate on interstate highways).", "However, because the vehicle is designed for traveling on conventional roadways, the vehicle is capable of maintaining speeds to keep pace with traffic.", "As such, in some cases, the vehicle is capable of traveling at speeds faster than 25 mph; and in some cases, faster than 35 mph; and in some cases, faster than 45 mph.", "Technical Problems The unmanned vehicle's control system may be programmed to monitor the condition of the vehicle.", "In some embodiments, the control system assesses technical problems being experienced by the vehicle, and if needed, the control system drives the vehicle to travel to a base facility (such as the nearest distribution facility, retail facility, or home base facility as will be described below) or to park itself (preferably at a safe place away from the flow of traffic).", "The vehicle may park at any suitable place, such as on the side of the road (e.g.", "on the shoulder), at an on-street parking site, or off-street parking site.", "Afterwards, the vehicle may standby and await the arrival of a recovery truck.", "The technical problems that can trigger this response may include one or more of: mechanical problem (e.g.", "flat tire), electrical problem (e.g.", "light beacon not working), electromechanical problem (e.g.", "electric motor malfunction), communication problem (e.g.", "loss of communication link), low battery charge, or low fuel.", "Detection and/or response to the problem may be performed autonomously or semi-autonomously (i.e.", "under a combination of human and autonomous control).", "For example, the vehicle may detect and assess the technical problem on its own and find safe parking on its own; or the problem may be assessed at the operations hub and the operations hub commands or guides the vehicle to a safe parking area; or some combination of these actions.", "In some embodiments, this response is triggered by the remaining battery charge falling below some threshold P, wherein P has a value in the range of 20% to zero (e.g.", "triggered when less than 17% battery charge remaining); in some cases, P has a value in the range of 15% to zero; in some cases, P has a value in the range of 10% to zero.", "In some embodiments, this response is triggered by the remaining amount of fuel falling below some threshold F, wherein F has a value in the range of 20% to zero (e.g.", "triggered when less than 18% fuel remaining); in some cases, F has a value in the range of 15% to zero; in some cases, F has a value in the range of 10% to zero.", "Surveillance System In some embodiments, the vehicle has a surveillance system that operates separately or in conjunction with the perception system.", "The surveillance system may share the same components as the perception system, such as using the same camera(s).", "The surveillance system is designed to counter hostile physical actions against the vehicle, such as vandalism.", "As such, the surveillance system may be operating during a time when the vehicle is not traveling or when the driving perception system is not active.", "For example, the surveillance system may be operating when the vehicle is parked.", "The surveillance system includes a multidirectional camera system that has one or more cameras for imaging in multiple directions.", "A variety of different configurations are possible for the camera system.", "For example, the camera system may have a single camera that can turn to different directions, or multiple cameras that are pointed in different directions.", "The cameras used may be the same or different from any cameras used in the perception system.", "The camera can be made to be easily visible or conspicuous to deter hostile physical actions against the vehicle (e.g.", "vandalism, theft, or aggressive driving against the vehicle).", "Warning Sign The vehicle may be the target of hostile physical actions, such as vandalism or other drivers on the road interfering with the operation of the vehicle (e.g.", "bump into it, nudge it, push if off the road, block its path, etc.).", "To deter this kind of hostile action, the vehicle may display an externally visible written warning notice.", "Examples of such warning notices include: “Vehicle Under Video Surveillance” or “Do Not Interfere with this Vehicle/Violators Will be Prosecuted.” Other methods for countering against hostile physical actions are also described herein.", "Communications Equipment The vehicle is equipped with radio communications equipment such as a receiver, transmitter, transceiver (e.g.", "cellular radio transceiver), and/or antenna.", "The radio communications equipment may be used for communicating with the operations hub and/or the customers.", "The radio communications equipment may operate via any suitable radio link such as a cellular network, WiFi, satellite, or combinations thereof.", "The radio communications equipment may be integrated with or in connection with the control system, surveillance system, and/or perception system of the vehicle.", "The vehicle may have audio and/or visual equipment to communicate with people standing near the vehicle.", "In some embodiments, the vehicle has an external loudspeaker, external microphone, and/or external video display screen.", "These can be useful in a variety of circumstances.", "For example, the external loudspeaker can be used to talk with the delivery recipient or passerby, or to ward off vandals (e.g.", "“please step away from the vehicle”), or make requests (e.g.", "“please move out of the way”).", "The microphone can allow the delivery recipient or passerby to speak with someone at the operations hub for the vehicle.", "For example, if the vehicle is improperly parked, a policeman can speak into the microphone to ask the operations hub to move the vehicle; or for example, a bystander can ask the operations hub to move the vehicle because it is blocking the way.", "In some embodiments, the vehicle has an electronic payment device (e.g.", "credit card reader, smartphone payment processor, etc.).", "In some cases, the electronic payment device is involved in unlocking or opening a cargo compartment door of the vehicle.", "For example, when the recipient makes a payment with the electronic payment device, the compartment door is unlocked so that the recipient can access the delivered item.", "Vehicle Suspension & Body Since the vehicle is not designed to carry passengers, the suspension design can be different from those typically used in contemporary passenger cars.", "In some embodiments, the vehicle has a suspension that uses springs (e.g.", "coil, leaf, etc.", "), but no damping mechanism (e.g.", "no shock absorbers).", "In some embodiments, the vehicle does not have a fully independent suspension system on all wheels.", "In such cases, only the front wheels, or only the rear wheels, or neither have an independent suspension.", "That is, the vehicle can have a suspension configuration with: (1) the front wheels are independently linked, but the rear wheels are dependently linked; (2) the rear wheels are independently linked, but the front wheels are dependently linked; (3) both the front and rear wheels are dependently linked.", "The vehicle may have 3-6 wheels.", "In some embodiments, the vehicle is steered at both the front and rear wheels (e.g.", "4-wheel steering).", "This can allow crab steering to facilitate parallel parking curbside.", "In some embodiments, the vehicle has wheels without separate tires, or has tires that are non-pneumatic (e.g.", "solid rubber tires or the Tweel made by Michelin) or semi-pneumatic.", "Semi-pneumatic tires have a hollow air-filled center, but the air is not pressurized.", "This feature can be useful in making the vehicle more resistant to vandalism (e.g.", "tire slashing).", "This feature can also be useful for reducing the maintenance cost of the vehicle.", "Also, since the vehicle is not designed to carry passengers, not being constrained by personal comfort considerations can lower the cost of the vehicle.", "Because the vehicle may be relatively lightweight, it may experience instability at higher travel speeds.", "Vehicle stability can be enhanced by aerodynamic design of the vehicle for reducing air turbulence around the vehicle, reducing aerodynamic lift, and/or produce downforce on the vehicle.", "Such designs can include shaping the vehicle body appropriately (e.g.", "a wedge shaped front), giving the vehicle a spoiler (to reduce turbulence and aerodynamic lift), and/or giving the vehicle a wing to produce downforce.", "Operations Hub Coordination of the delivery operations may be performed by an operations hub.", "To perform this, the operations hub may have personnel and equipment to remotely operate the vehicle, communicate with the vehicle (e.g.", "for sending commands, receiving monitoring information from the vehicle, etc.", "), and/or remotely monitor the vehicle.", "The operations hub can also communicate with any of the facilities described below (e.g.", "distribution facility, home base facility, local retail facility).", "Communications with the customer or recipient (sending and receiving) can be performed by operations hub or by the vehicle itself, and can be made via any suitable medium, such as through wired or wireless communication devices such as mobile phones, desktop computers, home control panel (for a home automation system), etc.", "The communications with the customer or recipient may be in the form of phone calls, voice messages, emails, text messages, message alerts, or any other suitable means of notification.", "The operations hub may be a single physical location or multiple physical locations that functionally work together.", "The operations hub may be physically and/or functionally combined or integrated with any of the facilities described below (e.g.", "distribution facility, home base facility, local retail facility), or it may be separate functionally and/or physically.", "In some embodiments, the person who remotely operates the unmanned vehicle has a driver's license in the state where the vehicle is being operated.", "The operations hub may be handling the operation of multiple unmanned ground vehicles.", "In some cases, the operations hub is in command of 10 or more vehicles; in some cases, 15 or more vehicles; in some cases, 25 or more vehicles.", "Vehicle Dimensions Because the vehicle should be large enough to carry cargo, the unmanned vehicle may have a dry (empty) weight of at least 450 lbs; in some cases, at least 550 lbs; in some cases, at least 700 lbs.", "But because the vehicle does not carry passengers, typical human comfort and safety features can be omitted, thus reducing the weight of the vehicle.", "As such, the unmanned vehicle may have a dry (empty) weight of less than 7,000 lbs; in some cases, less than 5,000 lbs.", "; in some cases, less than 3,000 lbs.", "; in some cases, less than 2,000 lbs.", "; in some cases, less than 1,500 lbs.", "In some embodiments, the unmanned vehicle has a wheelbase of at least 30 inches; in some cases, at least 40 inches; in some cases, at least 60 inches; in some cases, at least 75 inches.", "In some embodiments, the unmanned vehicle has a wheelbase of less than 210 inches; in some cases, less than 170 inches; in some cases, less than 150 inches; in some cases, less than 130 inches; in some cases, less than 105 inches.", "In some embodiments, the unmanned vehicle has a maximum payload capacity of at least 75 lbs; in some cases, at least 150 lbs; in some cases, at least 200 lbs; in some cases, at least 300 lbs; in some cases, at least 400 lbs; in some cases, at least 600 lbs; in some cases, at least 800 lbs.", "In some embodiments, the unmanned vehicle has a maximum payload capacity that is less than 2,000 lbs; in some cases, less than 1,500 lbs; in some cases, less than 1,200 lbs; in some cases, less than 900 lbs.", "In some embodiments, the unmanned vehicle has a total cargo volume of at least 20 cu ft; in some cases, at least 40 cu ft; in some cases, at least 60 cu ft; in some cases, at least 90 cu ft.", "In some embodiments, the vehicle has a total cargo volume of less than 600 cu ft; in some cases, less than 400 cu ft; in some cases, less than 200 cu ft; in some cases, less than 100 cu ft.", "Examples of vehicle dimensions that may be suitable include those similar to the Smart™ electric minicar, 4-wheel all-terrain or sport utility vehicles (ATV), or golf carts.", "Since the unmanned ground vehicle is not designed to carry passengers, it can have a relatively narrower width.", "In some embodiments, both the front and rear track widths of the vehicle are narrower than 80 inches; in some cases, narrower than 75 inches; in some cases, narrower than 70 inches; in some cases, narrower than 65 inches; in some cases, narrower than 60 inches; in some cases, narrower than 55 inches; in some cases, narrower than 50 inches; in some cases, narrower than 45 inches; in some cases, narrower than 40 inches.", "In some embodiments, the main body of the unmanned vehicle has a height of less than 8 feet (not including projecting elements such as antennas, cameras, signal lights, perception apparatus, light beacons, or other accessory elements, etc.", "); in some cases, less than 7 feet; in some cases, less than 6 feet; in some cases, less than 5 feet 6 inches; in some cases, less than 5 feet.", "However, because the vehicle may be designed to allow recipients to easily access the delivered items without the need for special equipment, the height should not be too low.", "In some embodiments, the main body of the unmanned vehicle has a height of greater than 4 feet; in some cases, greater than 5 feet.", "Low Center of Gravity The vehicle can be made to have a relatively lower center of gravity (CoG) height.", "This feature can be useful for a variety of reasons, including improving vehicle stability while traveling or resisting tipping-over by vandals.", "In some embodiments, the vehicle (unloaded and empty of fuel, if any required) has a CoG height of lower than 25 inches from the ground; in some cases, lower than 24 inches; in some cases, lower than 23 inches; in some cases, lower than 22 inches; in some cases, lower than 21 inches; in some cases, lower than 20 inches; in some cases, lower than 19 inches; in some cases, lower than 18 inches; in some cases, lower than 17 inches; in some cases, lower than 16 inches from the ground.", "The CoG height can be lowered by placement of batteries, electric drive motors, and other equipment closer to the ground level, or reducing the height of the vehicle.", "As such, in some embodiments, any batteries and/or electric drive motors of the vehicle are positioned beneath a cargo compartment or located at a level beneath a cargo compartment of the vehicle.", "Road Operating Equipment The unmanned vehicle also has equipment for operating on roadways.", "For example, the unmanned vehicle may have a signal light (e.g.", "turn signal light); brake light (on the rear); forward facing light (e.g.", "headlights or beam lights) for illumination when operating during nighttime or reduced visibility conditions; exterior light (e.g.", "navigation light, emergency light, hazard light, strobe light, flashing light, spinning light, etc.)", "and/or reflector to enhance the conspicuousness of the unmanned vehicle to others; illuminated license plate; etc.", "The unmanned vehicle may also be covered under liability insurance for personal injury and/or property damage.", "Cargo Compartment The unmanned vehicle has one or more compartments for holding delivery cargo.", "The compartments may be closed/locked and be opened/unlocked in a secure manner.", "For example, the compartments may be opened/unlocked remotely by the operations hub upon request by the recipient.", "In another example, the recipient may be given an access code (e.g.", "via a smartphone) and the vehicle has an external keypad for entering the access code.", "Entry of the correct access code will open/unlock the compartment.", "In another example, the compartments may be unlocked/opened by the recipient's personal electronic device such as a smartphone.", "In some embodiments, one or more of the compartments are designed for holding cold food items.", "For example, such cold compartments could be thermally-insulated (specifically designed for thermal insulation) and/or cooled.", "Temperature cooling can be provided in any suitable manner.", "For example, cooling could be provided by using refrigerant materials such as water ice, dry ice, or reusable cold packs (e.g.", "gel bags or bricks).", "In another example, cooling could be provided by electrical refrigeration.", "In some embodiments, the vehicle has multiple separate cargo compartments that are individually accessible and/or lockable.", "This can allow the vehicle to make multiple deliveries to different recipients.", "For example, the vehicle can travel to one destination and deliver an item contained in one compartment, and then travel to another destination and deliver another item contained in a different compartment.", "The cargo compartment may also have lighting to enhance visibility for the user, which may be particularly useful for nighttime deliveries.", "The lighting may be activated by opening of the compartment door.", "The vehicle may also have a camera for monitoring inside the compartment(s).", "This can be useful for preventing theft or monitoring the security of the contents.", "For safety reasons, access to the cargo compartment (e.g.", "cargo door) may be located away from the side facing the street.", "For example, the cargo compartment access may be located only on the right side (with respect to the forward direction), top side, front side, and/or back side of the vehicle.", "In some cases, access to the cargo compartment is not located on the left side of the vehicle.", "Vehicle Power Source The unmanned vehicle may be propelled by any suitable power source, including conventional power sources such as gasoline or diesel, or alternative power sources such as battery-electric, natural gas, fuel cell, hybrid-electric, etc., or any combination thereof.", "Because the unmanned vehicle may be making mostly short trips, the unmanned vehicle may be powered by range-limited power sources, such as by electricity accumulator apparatus (e.g.", "batteries or capacitors).", "In some cases, the vehicle may be hybrid-powered, i.e.", "electrically-powered in combination with a fuel engine.", "In some cases, such electrically-powered vehicles may not have (omit) any apparatus for generating electricity from fuel (e.g.", "fuel cell or gasoline-powered generator).", "For example, the unmanned vehicle may draw all its motive power from electricity accumulators only (e.g.", "battery-only) and has no other source of motive power or electricity generation.", "The vehicle is propelled by one or more motors, which can be electric or fuel powered.", "Because the unmanned vehicle does not carry passengers and because it may be designed to be relatively lighter and relatively slower, the motor power of the vehicle may be relatively weaker compared to passenger cars.", "In this regard, the following embodiments are possible.", "In embodiments where the vehicle is propelled by electric motor(s) only and if the vehicle has only a single electric motor, in some cases, the rated maximum horsepower of the electric motor may be less than 90 hp; and in some cases, less than 75 hp; and in some cases, less than 60 hp.", "However, because the vehicle is designed for traveling on conventional roadways, the vehicle should have sufficient power to maintain a speed that keeps pace with traffic.", "As such, the rated maximum horsepower of the electric motor may be greater than 25 hp; and in some cases, greater than 35 hp.", "In embodiments where the vehicle is propelled by electric motor(s) only and if the vehicle has multiple electric motors (e.g.", "one on each of the front wheels), in some cases, the rated maximum horsepower of each electric motor may be less than 75 hp; and in some cases, less than 60 hp; and in some cases, less than 45 hp.", "However, because the vehicle is designed for traveling on conventional roadways, the vehicle should have sufficient power to maintain a speed that keeps pace with traffic.", "As such, the rated maximum horsepower of each electric motor may be greater than 15 hp; and in some cases, greater than 20 hp.", "In embodiments where the vehicle is propelled by a combination of an internal combustion motor and electric motor(s) (i.e.", "a hybrid-powered vehicle) and if the vehicle has only a single electric motor, in some cases, the rated maximum horsepower of the electric motor may be less than 60 hp; and in some cases, less than 45 hp; and in some cases, less than 30 hp.", "In embodiments where the vehicle is propelled by a combination of an internal combustion motor and electric motor(s) (i.e.", "a hybrid-powered vehicle) and if the vehicle has multiple electric motors, in some cases, the rated maximum horsepower of each electric motor may be less than 45 hp; and in some cases, less than 30 hp; and in some cases, less than 20 hp.", "In embodiments where the vehicle is propelled by an internal combustion motor (exclusively or in conjunction with an electric motor), a relatively smaller motor may be used as compared to passenger cars.", "In some cases, the internal combustion motor has only three cylinders, in some cases only two cylinders, in some cases only a single cylinder.", "The relatively smaller motor can also be characterized by its displacement volume.", "In some cases, the displacement volume of the internal combustion motor may be less than 900 cc; in some cases, less than 750 cc; in some cases, less than 600 cc.", "Unmanned Operation Not having a human operator on board, the unmanned vehicle is able to operate on roadways in ordinary conditions without any human control, i.e.", "autonomously.", "The unmanned vehicle operates fully autonomously or partly autonomously, i.e.", "under a combination of human and autonomous control.", "For example, although the vehicle may be fully capable of driving autonomously, this autonomous control may be supplemented by human control via remote-operation on a as-needed basis, such as for vehicle breakdown, changes in traffic patterns, road construction, road or lane closures, detours, traffic accidents, severe weather conditions, or some other unexpected disruption to roadway traveling conditions.", "Thus, any reference made herein about the unmanned vehicle traveling to various places means that the vehicle is driven at least partly in an autonomous manner.", "The unmanned vehicle is designed to carry cargo but not human passengers.", "Because the unmanned vehicle is not designed for onboard human presence, the vehicle may not have one or more of the following: seats for passengers, windows, seatbelts, airbags, climate control (e.g.", "heating or air conditioning), audio entertainment system, passenger doors, etc.", "Because the autonomous vehicle is designed to operate without a human driver inside the vehicle, the vehicle may not have (omit) one or more of the following: steering wheel, gear lever or selector, accelerator pedal, foot brake, speedometer, side view mirror, rear view mirror, glass windshield, windshield wiper, etc.", "Example Vehicle FIGS.", "1A-1C show an example of the unmanned ground vehicle of our invention.", "A flashing light beacon 30 is mounted on the roof of the main body 10.A perception apparatus 20 (here, a lidar apparatus) is mounted on top of the light beacon 30.The vehicle has a cargo compartment which can be accessed by opening the cargo door 12 (having hinges 15 and door handle 14).", "To unlock the cargo door 12, the customer enters the correct access code into the keypad 42.To improve visibility and safety, the vehicle also has a reflector stripe 16 and rear brake lights 44.The vehicle is also equipped with an audio loudspeaker 40 so that someone in the operations hub can speak with the delivery customer or bystanders.", "Uses of the Autonomous Unmanned Road Vehicle The autonomous unmanned road vehicle of our invention can be used in a variety of ways for making deliveries.", "The delivery destinations can be designated in any suitable manner to identify its location, such as GPS (global positioning system) coordinates, cellular network, and/or postal address as recognized by the postal service, emergency services (fire, ambulance, etc.", "), mapping agencies or firms, or courier services, etc.", "For example, a delivery destination may be designated as 1250 Main Street, Anytown, Mass.", "90210 (fictitious address).", "The delivery destinations can be specified in even more detail (e.g.", "a specific side of a corner or a specific side of a building).", "Non-limiting examples of delivery destinations include residences and businesses, such as restaurants, offices, retail stores, etc.", "The delivery is received by the recipient or customer, or someone on their behalf, such as a family member, friend, roommate, doorman, receptionist, etc.", "Because the items may be delivered without assistance, in some embodiments, the weight of each single item (e.g.", "a parcel) or bundled item (e.g.", "a shopping bag or box filled with grocery items), which is intended to be carried as a unit, may be relatively light such that they can be lifted or picked-up without assistance.", "In some cases, each single or bundled item being delivered weighs less than 90 lbs; in some cases, less than 75 lbs; in some cases, less than 50 lbs; in some cases, less than 25 lbs; in some cases, less than 20 lbs.", "A.", "Delivery of Packages In one embodiment, the unmanned vehicle can be used for delivering packages (e.g.", "boxes, parcels, envelopes, shipments, mail items, letters, etc.)", "that are destined for multiple (two or more) delivery destinations.", "This can be useful in situations where the recipient is not present at the delivery destination when the delivery is ready to be made.", "As such, the recipient can request delivery upon demand.", "Our invention can be particularly useful in making deliveries to residences (i.e.", "the delivery destinations are peoples' homes).", "For example, the recipient may not be able to receive their package until they return home from work, but can request delivery after they arrive home from work.", "The residences may be located in an area that is zoned for residential use.", "Because the packages may be delivered to the recipient without assistance, in some embodiments, the packages for delivery may be limited to those that are relatively lighter such that they can be lifted or picked-up without assistance.", "In some cases, each of the packages are less than 90 lbs in weight; in some cases, less than 75 lbs in weight; in some cases, less than 50 lbs in weight.", "Distribution Facility At a distribution facility, one or more packages for delivery are loaded onto the unmanned vehicle.", "The distribution facility can be any facility that provides a place to receive packages and load them onto the unmanned vehicle.", "Non-limiting examples of distribution facilities include warehouses, distribution centers, sorting facilities, loading facilities, processing facilities, transportation facilities, etc.", "Other examples of distribution facilities that can be used by our invention are further described below.", "The distribution facility may further be involved in receiving, sorting, storing, and/or processing packages.", "The distribution facility may be combined or integrated with an operations hub.", "The distribution facilities referred to herein can be part of a larger distribution network.", "Regional and Local Distribution Facilities In certain embodiments, our invention uses one or more regional distribution facilities that each distribute packages to multiple (two or more) local distribution facilities, each of which serves a delivery zone with multiple delivery destinations.", "At a regional distribution facility, the packages are loaded onto a transport vehicle for delivery to a local distribution facility.", "The vehicle used in this transport phase may be any conventional ground vehicle and does not have to be an unmanned vehicle.", "The transport vehicle then travels to the local distribution facility, which is responsible for delivering the packages to their delivery destinations.", "At the local distribution facility, the transport vehicle may wait without unloading or unload the packages destined for the delivery destinations served by the local distribution facility.", "The local distribution facility is connected to the delivery destinations via paved roadways.", "To provide timely on-demand delivery, the local distribution facility is generally located close to the delivery destinations.", "In some embodiments, all the delivery destinations served by the local distribution facility are within a 10 mile radius of the local distribution facility; in some cases, within a 6 mile radius; in some cases, within a 3 mile radius.", "In some embodiments, at least 85% of the delivery destinations served by the local distribution facility are within a 10 mile radius of the local distribution facility; in some cases, within a 6 mile radius; in some cases, within a 3 mile radius.", "In some cases, the local distribution facility is dedicated solely for the delivery service.", "But in other cases, the local distribution facility may be located at a business facility that operates a different type of business (other than the delivery service), such as a retail store, office building, gas station, parking garage or parking lot, or school.", "For example, the delivery service may be operated out of a back room, on the parking lot, or from the back alley of the business facility.", "Examples of retail stores where the local distribution facility could be located include grocery store, supermarket, warehouse store, department store, convenience store, variety store, drug or pharmacy store, electronics store, restaurant, office supply store, hardware or building supply store, etc.", "This is a useful feature because many retail stores already exist in close proximity to residential areas (e.g.", "neighborhood grocery stores).", "In some embodiments, the local distribution facility is located at an already-established business facility that has been modified to also operate the delivery service but continues to operate the already-existing business (e.g.", "by remodeling, renovation, or other modification of the premises such that it can continue the already-operating business).", "For example, a back room or area of a retail store (e.g.", "grocery store or convenience store) could be converted or renovated to operate the delivery service.", "In another example, the parking lot of a shopping center could be equipped to hold and maintain a fleet of unmanned vehicles, along with other equipment, personnel, and/or housing to operate the delivery service.", "In cases where the local distribution facility is located at a business facility that also operates a different type of business, there may be some employee staff who are dedicated to the delivery service (e.g.", "maintaining or operating the vehicles).", "However, it may also be possible to have employee(s) who work both the other business operations and also the delivery service.", "As such, in some cases, the business facility operates with at least one employee in at least one work shift working in both the other business operation and the delivery service; and in some cases, at least three employees in at least one work shift who work in this manner.", "In some embodiments, the local distribution facility is located in an area that is zoned for commercial, industrial, and/or mixed residential-commercial use.", "In some embodiments, there is a residential area or an area that is zoned for residential use located within a 6 mile radius of the local distribution facility; in some cases, within a 3 mile radius.", "This can be a useful feature because many deliveries may be made to residences.", "In some cases, the local distribution facility has a covered garage for storing the vehicle(s) when not in use (e.g.", "during idle time or overnight).", "Because the regional distribution facility does not necessarily provide on-demand delivery, it can generally be located farther away from the delivery destinations served by the local distribution facility.", "In some embodiments, all the delivery destinations served by the local distribution facility are outside a 1 mile radius of the regional distribution facility; in some cases, outside a 3 mile radius; in some cases, outside a 6 mile radius.", "In some embodiments, at least 85% of the delivery destinations served by the local distribution facility are outside a 1 mile radius of the regional distribution facility; in some cases, outside a 3 mile radius; in some cases, outside a 6 mile radius.", "These statistical parameters may be applicable to a particular regional distribution facility, a particular local distribution facility, or system-wide.", "That is, infringement of our patent may occur at the level of the particular regional distribution facility, local distribution facility, or system-wide.", "The recipients are notified that their packages are ready for delivery.", "This notification may occur at any suitable time point, such as after the packages arrive at the local distribution facility.", "This notification to the recipients may be performed by the operations hub.", "After receiving this notification, a recipient can request delivery of their package(s) (e.g.", "by replying back to the ready notification).", "This delivery request is received at the local distribution facility (e.g.", "via the operations hub) and the requested package(s) is loaded onto an unmanned ground vehicle.", "If multiple delivery requests are received, the packages for the multiple requests may be loaded.", "The unmanned vehicle is then sent to the recipient's delivery destination.", "The unmanned ground vehicle travels, being driven at least partly in an autonomous manner, to the recipient's delivery destination via a paved roadway.", "To confirm the recipient's request, the recipient may be notified (e.g.", "by the operations hub) that the requested package(s) is on its way.", "This notification may occur at any suitable time point, such as when the package(s) is loaded onto the unmanned vehicle or when the vehicle is in transit to the delivery destination.", "Because the unmanned vehicle is expected to make deliveries through multiple round trips as demanded, for each excursion from the local distribution facility, the vehicle carries less than the total number of packages to be delivered for all the delivery destinations being served by that local distribution facility.", "For example, considering a hypothetical situation in which the local distribution facility has to deliver a total of 28 packages for delivery to 25 delivery destinations, the vehicle may end up making 20 round trips to make these deliveries, and for each round trip, carry the package(s) for only one or two delivery destinations.", "In some embodiments, for each excursion from the local distribution facility to make a delivery(s), the vehicle visits only two delivery destinations or fewer before returning back to the local distribution facility; in some cases, visits only three delivery destinations or fewer; in some cases, visits only four delivery destinations or fewer.", "FIG.", "6 shows an example of how the our invention can be implemented.", "At a regional distribution facility 60, a conventional delivery truck 62 is loaded with packages that are destined for multiple residential delivery destinations (▴).", "After loading, the truck 62 travels to local distribution facility 70.Here, the packages destined for delivery zone X are unloaded.", "All the delivery destinations in delivery zone X are within a 6 mile radius of the local distribution facility 70.After unloading the packages at local distribution facility 70, the truck 62 then travels to local distribution facility 72 to drop-off their packages.", "The operations hub notifies the package recipients that their packages are ready for delivery to their delivery destinations.", "When a recipient in delivery zone X requests a delivery (e.g.", "upon returning home from work), the recipient's package(s) is loaded into an unmanned ground vehicle 74 at local distribution facility 70.On command, the unmanned vehicle 74 then travels to the recipient's delivery destination in delivery zone X.", "In transit, the operations hub notifies the recipient that the package is on its way.", "When the unmanned delivery vehicle 74 arrives at the delivery destination, the operations hub notifies the recipient that the package has arrived and provides an access code for opening the cargo compartment of the unmanned delivery vehicle.", "When the recipient enters the correct access code (e.g.", "on an external keypad on the unmanned vehicle), the cargo door is unlocked.", "The recipient picks-up the package and closes the cargo door.", "The recipient presses a button on the unmanned vehicle indicating that the package delivery is completed.", "With this, the unmanned vehicle 74 makes another delivery or returns to the local distribution facility 70.Delivery to a recipient in delivery zone Y can be made in the same manner, using an unmanned ground vehicle 76 sent from local distribution facility 72.Waiting Areas In certain embodiments, our invention uses a waiting area where the unmanned vehicle can park while it awaits its next delivery request (e.g.", "in between deliveries).", "At a base distribution facility (e.g.", "a local distribution facility), the unmanned ground vehicle is loaded with multiple packages to be delivered to multiple delivery destinations.", "With the packages loaded, the unmanned vehicle leaves the base distribution facility and drives, at least partly in an autonomous manner, to the waiting area (although it may first make a delivery(s) before arriving at the waiting area).", "The unmanned vehicle parks at the waiting area and awaits a command to make the next delivery.", "The waiting area is a location that is a short distance away from the delivery destinations so that deliveries can be made on-demand.", "In some embodiments, all the delivery destinations being served by the unmanned vehicle are within a 10 mile radius of the waiting area; in some cases, within a 6 mile radius; in some cases, within a 3 mile radius.", "In some embodiments, at least 85% of the delivery destinations being served by the unmanned vehicle are within a 10 mile radius of the waiting area; in some cases, within a 6 mile radius; in some cases, within a 3 mile radius.", "These statistical parameters may be applicable to a particular base facility or system-wide.", "That is, infringement of our patent may occur at the level of the particular base facility or system-wide.", "Any suitable location where the unmanned vehicle can temporarily park can serve as the waiting area.", "In some embodiments, the waiting area can be an on-street parking site (e.g.", "curbside parking) and/or an off-street parking site such as a parking structure, surface parking lot, or even a residential garage or driveway (with the owner's authorization).", "In some embodiments, the waiting area is located at a business facility that operates a different type of business (other than the delivery service) as explained above, such as a retail store.", "For example, the waiting area can be in the parking lot of a grocery store.", "In cases where the waiting area is located at a business facility, there may be some employee staff who are dedicated to the delivery service (e.g.", "maintaining or operating the vehicles).", "However, it may also be possible to have employee(s) who work both the other business operations and also the delivery service.", "As such, in some cases, the business facility operates with at least one employee in at least one work shift working in both the other business operation and the delivery service; and in some cases, at least three employees in at least one work shift who work in this manner.", "In some embodiments, the waiting area has equipment and/or personnel for maintaining the unmanned vehicle (e.g.", "recharging equipment, refueling equipment, repair equipment, tow truck or recovery truck, security guards to guard over the vehicles, repair personnel, etc.).", "In some embodiments, the waiting area is located in an area that is zoned for commercial, industrial, and/or mixed residential-commercial use.", "There may be more than one waiting area available for serving the delivery destinations.", "For example, after making a delivery, the closest of several predetermined waiting areas may be selected.", "But the waiting area(s) does not necessarily have to be pre-determined.", "For example, a waiting area may be found on an ad hoc basis (e.g.", "if the usual waiting area is not available).", "In another example, after making a delivery, that delivery destination or somewhere close may be made as the current waiting area.", "The recipients are notified that their packages are ready for delivery.", "This notification may occur at any suitable time point, such as after the packages are loaded onto the unmanned delivery vehicle or when the unmanned vehicle arrives at the waiting area.", "This notification to the recipients may be performed by the operations hub.", "After receiving this notification, a recipient can request delivery of the package(s) (e.g.", "by replying back to the ready notification).", "The operations hub sends a command to the unmanned vehicle to make the requested delivery.", "The unmanned ground vehicle then travels, being driven at least partly in an autonomous manner, to the recipient's delivery destination via a paved roadway.", "To confirm the recipient's request, the recipient may be notified (e.g.", "by the operations hub) that the requested package(s) is on its way.", "This notification may occur at any suitable time point, such as when the vehicle is in transit to the delivery destination.", "FIG.", "7 shows another example of how the our invention can be implemented.", "At a base distribution facility 80, unmanned ground vehicles 82 and 84 are loaded with packages that are destined for multiple residential delivery destinations (▴) within their assigned delivery zones A and B.", "After loading, the unmanned vehicles are sent on their way to their respective delivery zones A and B.", "Each vehicle travels to its respective waiting area (X) and parks there, awaiting a command to make a delivery.", "Alternatively, the vehicle may make a delivery(s) before traveling to the waiting area.", "All the delivery destinations being served by the unmanned vehicle for that particular excursion are within a 6 mile radius of the waiting area (X).", "Although FIG.", "7 shows the waiting area being within the delivery zone, this does not have to be the case.", "For example, the delivery zone may be a residential area, but the waiting area may be located in a commercial zone that is adjacent to the residential area.", "In transit, the operations hub notifies the package recipients that their packages are ready for delivery to their delivery destinations.", "When a recipient in delivery zone A requests a delivery (e.g.", "upon returning home from work), the operations hub sends a command to the unmanned vehicle 82 for delivery zone A to make that delivery.", "The unmanned vehicle 82 departs from the waiting area and travels to the delivery destination.", "In transit to the recipient's delivery destination, the operations hub notifies the recipient that the package is on its way.", "When the unmanned delivery vehicle 82 arrives at the delivery destination, the operations hub notifies the recipient that the package has arrived and provides an access code for opening the cargo compartment of the unmanned delivery vehicle.", "When the recipient enters the correct access code (e.g.", "on an external keypad on the unmanned vehicle), the cargo door is unlocked.", "The recipient picks-up the package and closes the cargo door.", "The recipient presses a button on the unmanned vehicle indicating that the package delivery is completed.", "With this, the unmanned vehicle 82 makes another delivery or returns to the waiting area.", "Delivery to a recipient in delivery zone B can be made in the same manner using unmanned ground vehicle 84.General Embodiment In certain embodiments, our invention may be considered more generally as a method of transporting packages that are destined for multiple delivery destinations using an unmanned ground vehicle.", "The packages are transported from a first location to a second (intermediate) location.", "Examples of first locations include regional distribution facilities and base distribution facilities as described above (e.g.", "a local distribution facility); examples of intermediate locations include local distribution facilities and waiting areas as described above.", "(Note that a local distribution facility can be considered a first location or an intermediate location, depending upon the overall configuration of the delivery network.)", "The intermediate location is connected with the delivery destinations via paved roadways.", "In some embodiments, all the delivery destinations are within a 10 mile radius of the intermediate location; in some cases, within a 6 mile radius; in some cases, within a 3 mile radius.", "In some embodiments, at least 85% of the delivery destinations are within a 10 mile radius of the intermediate location; in some cases, within a 6 mile radius; in some cases, within a 3 mile radius.", "These statistical parameters may be applicable to a particular first location, particular intermediate location, or system-wide.", "That is, infringement of our patent may occur at the level of the particular first location, particular intermediate location, or system-wide.", "In some embodiments, all the delivery destinations are outside a 1 mile radius of the first location; in some cases, outside a 3 mile radius; in some cases, outside a 6 mile radius.", "In some embodiments, at least 85% of the delivery destinations are outside a 1 mile radius of the first location; in some cases, outside a 3 mile radius; in some cases, outside a 6 mile radius.", "These statistical parameters may be applicable to a particular first location or system-wide.", "That is, infringement of our patent may occur at the level of the particular first location or system-wide.", "The method comprises notifying the recipients that their packages are ready for delivery.", "After receiving this notification, a recipient may communicate a request notification requesting delivery of their package to the delivery destination.", "In response to the delivery request, an unmanned ground vehicle that is loaded with the package(s) is sent from an intermediate location to the recipient's delivery destination on a paved roadway.", "The unmanned ground vehicle travels, being driven at least partly in an autonomous manner, to the recipient's delivery destination via a paved roadway.", "The recipient is notified that their package has arrived or will be arriving.", "After making the delivery, the unmanned ground vehicle makes another delivery or is driven, at least partly in an autonomous manner, on a paved roadway back to the intermediate location.", "Delivery Performance Because the second (intermediate) location is located close to the recipient's delivery destination, our invention can provide on-demand delivery in a timely manner.", "In some embodiments, greater than 50% of the deliveries arrive at the recipient's delivery destination within 45 minutes of the delivery request; and in some cases, greater than 75% (as applied to a particular first location and/or system-wide).", "Whereas in conventional delivery methods the recipient often must accommodate to the delivery schedule, our delivery method allows the deliveries to be made at a time convenient for the recipient.", "For example, many working people are not at home during the workday.", "Our invention can offer the convenience of receiving a package during after-work hours.", "While at work, the recipient may receive a notification that a package has arrived and is ready for delivery.", "When the recipient returns home, they can request delivery of the package to their home.", "As such, in some embodiments, at least 50% of the weekday deliveries to residences are made between the hours of 3 pm to 11 pm (as applied to a particular first location and/or system-wide); in some cases, at least 70% of the weekday deliveries as aforementioned.", "B.", "Delivery of Retail Goods In this embodiment, our invention provides another method of delivering retail goods to customers using an unmanned ground vehicle.", "A variety of different types of retail goods can be delivered using our method.", "For example, the retail goods may be food products (e.g.", "groceries or prepared meals); consumables (e.g.", "baby care, medicines, personal care products, health care products, beauty care products, household products, cleaning supplies, clothing/apparel, etc.", "); and/or durable goods (e.g.", "electronics, appliances, hardware supplies, etc.).", "Such retail goods may be found in retail stores such as grocery stores, supermarkets, hypermarkets, warehouse stores, department stores, convenience stores, variety stores, drug or pharmacy stores, electronics stores, restaurants, etc.", "Purchase Order A purchase order is received from a customer.", "The purchase order includes one or more purchased items to be delivered to the customer at a designated delivery destination.", "The customer can make the purchase order in any suitable manner, such using a wired or wireless communication devices (e.g.", "mobile phones), desktop computers, home control panel (for a home automation system), etc.", "The purchase order can be made through any suitable type of interface, such as website with a browser, specialized programs (e.g.", "smartphone apps), telephone menu, an automated home inventory system, etc.", "For example, the purchase order can be placed through the Internet using a smartphone.", "Local Retail Facility The purchase order is received by and/or transmitted to a local retail facility that serves end-user/consumer customers, i.e.", "stocks products that are packaged in a manner intended for the end-user/consumer.", "The local retail facility is connected to the customer's delivery destination via paved roadways.", "To provide timely on-demand delivery, the local retail facility is generally located close to the customer's delivery destination.", "In some embodiments, the local retail facility is located within a 10 mile radius of the customer's delivery destination; in some cases, within a 6 mile radius; in some cases, within a 3 mile radius.", "In some embodiments, there is a residential area or an area that is zoned for residential use located within a 6 mile radius of the local retail facility; in some cases, within a 3 mile radius.", "This can be a useful feature because many deliveries may be made to residences.", "Delivery Packaging At the local retail facility, the item(s) in the customer's purchase order are collected and placed into one or more delivery packaging that are designated for that customer's purchase order.", "The delivery packaging may be disposable or reusable, and may take any suitable form such as paper or plastic bags, cardboard boxes, cartons, plastic containers, etc.", "There may be delivery packaging of different types, shapes, sizes, etc., to accommodate different types of merchandise or different quantities of merchandise.", "For example, non-perishable goods may be put into disposable paper bags and perishable food products may be put into reusable insulated plastic containers.", "Depending upon the type and quantity of merchandise in the purchase order, the purchased items may be held in multiple delivery packaging.", "Different packaging may used together.", "For example, multiple paper bags may be put into a larger plastic container.", "Some purchased items may be too large or bulky to place into a delivery packaging.", "Such items may be held as loose items while waiting to be loaded onto the delivery vehicle.", "Because the purchased items may be delivered without assistance, in some embodiments, the total weight of each packaging holding the purchased item(s) may be relatively light such that they can be lifted or picked-up without assistance.", "In some cases, each of the loaded delivery packaging weighs less than 50 lbs; in some cases, less than 25 lbs; in some cases, less than 20 lbs.", "The customer's purchase order may include cold food products (e.g.", "cooled, refrigerated, frozen, or perishable), such as produce, frozen foods, milk, fruit juices, meats, cheese, dairy, eggs, etc.", "To maintain freshness while waiting to be loaded onto the delivery vehicle, packaging holding cold food items could be stored in a cooled space at the local retail facility, such as a refrigerator or freezer.", "For example, they could be stored in a large commercial refrigerator or a refrigerated room such as a walk-in cooler, refrigerator, or freezer.", "Alternatively or in combination, cold food items could be placed into special delivery containers that are thermally-insulated (specifically designed for thermal insulation) and/or cooled.", "Temperature cooling can be provided in any suitable manner.", "For example, cooling could be provided by using refrigerant materials such as water ice, dry ice, or reusable cold packs (e.g.", "gel bags or bricks).", "In another example, cooling could be provided by electrical refrigeration.", "Walk-In Retail Store In some cases, the local retail facility is specialized solely for delivery service of the retail goods (similar to a warehouse).", "But in other cases, the local retail facility may operate as both a conventional walk-in retail store and a delivery service.", "Examples of walk-in retail stores include grocery stores, supermarkets, hypermarkets, warehouse stores, department stores, convenience stores, variety stores, drug or pharmacy stores, electronics stores, restaurants, office supply store, hardware or building supply store, etc.", "For example, the delivery service may be operated out of one or more back rooms or areas of the walk-in retail store.", "The inventory of merchandise for the walk-in retail store may also be used to supply the delivery service.", "In some cases, the local retail facility is an already-established conventional walk-in retail store that has been modified to also operate the delivery service but continues to operate the already-existing business (e.g.", "by remodeling, renovation, or other modification of the premises such that it can continue the already-operating business).", "For example, one or more back rooms or areas of the walk-in retail store could be converted or renovated to operate the delivery service.", "This is a useful feature because many retail stores already exist in close proximity to residential areas (e.g.", "neighborhood grocery stores).", "In cases where the local retail facility operates as both a conventional walk-in retail store and a delivery service, there may be some employee staff who are dedicated to the delivery service (e.g.", "maintaining or operating the vehicles).", "However, it may also be possible to have employee(s) who work both the walk-in retail store and also the delivery service.", "As such, in some cases, the local retail facility operates with at least one employee in at least one work shift working in both the walk-in retail store and the delivery service; and in some cases, at least three employees in at least one work shift who work in this manner.", "Delivery The customer is notified when their purchase order is ready for delivery.", "The purchase order is ready for delivery and now awaits a delivery request from the customer.", "When the customer's delivery request is received, the package(s) containing the customer's purchase order are loaded into an unmanned ground vehicle.", "The unmanned ground vehicle is not the possession of the customer.", "Some other party, such as the local retail facility, has legal possession of the unmanned ground vehicle (e.g.", "owns, leases, or through other contractual arrangement).", "In some cases, the local retail facility has a vehicle bay where the unmanned ground vehicle(s) is parked while being loaded.", "Because the unmanned vehicle may have a lower height than conventional delivery trucks, in some cases, the vehicle bay has a clearance height (e.g.", "ceiling height) of less than 15 feet; in some cases, less than 12 feet; in some cases, less than 10 feet of clearance height.", "In some cases, the local retail facility has a covered garage for storing the vehicle(s) when not in use (e.g.", "during idle time or overnight).", "The unmanned vehicle is then sent to the customer's delivery destination.", "The unmanned vehicle travels, being driven at least partly in an autonomous manner, to the delivery destination via a paved roadway.", "To confirm the customer's delivery request, the customer may be notified (e.g.", "by the operations hub) that the delivery is on its way.", "This notification may occur at any suitable time point, such as when the goods are loaded onto the unmanned vehicle or when the vehicle is in transit to the delivery destination.", "In some cases, one or more of the packaging used for making the delivery is reusable and intended to be returned to the local retail facility.", "For example, the container holding the cold food items may be designed for reuse.", "The recipient removes the container from the vehicle and unpacks it (e.g.", "move the cold food items into the refrigerator).", "During this time, the vehicle will stand-by until the container is returned to the vehicle.", "Delivery Performance Because the local retail facility is located close to the customer's delivery destination and the customer's purchase order is prepared before the delivery request, our invention can provide on-demand delivery in a timely manner.", "In some embodiments, greater than 50% of the purchase orders made by the customers arrive at the delivery destination within 45 minutes of the customers' delivery request; and in some cases, greater than 75% (as applied to a particular local retail facility and/or system-wide).", "Whereas in conventional delivery methods the customer often must accommodate to the delivery schedule, our delivery method allows the deliveries to be made at a time convenient for the customer.", "For example, for many customers, receiving deliveries at home after work hours is more convenient.", "In some embodiments of our invention, greater than 50% of the weekday (Monday-Friday) deliveries are made in the hours of 3 pm to 11 pm; in some cases, greater than 70% (as applied to a particular local retail facility and/or system-wide).", "Our method can provide same day delivery with high reliability.", "In some cases, greater than 75% of the purchase orders received between the hours of 7 am to 3 pm are delivered the same day; in some cases, greater than 90% of the purchase orders received between the hours of 7 am to 3 pm are delivered the same day (as applied to a particular local retail facility and/or system-wide).", "Because our method uses unmanned delivery vehicles, a high volume of deliveries can be made.", "In some cases, a local retail facility makes an average of 25 purchase order deliveries per day; in some cases, an average of 60 per day; in some cases, an average of 125 per day.", "Our invention can be useful in situations where the customer will not be present at the delivery destination when the delivery is ready to be sent.", "For example, many working people are not at home during the workday.", "Our invention can offer the convenience of making a purchase order in the morning or afternoon hours (e.g.", "at their workplace).", "When they return home, they can request delivery of the purchased goods to their homes.", "As such, in some embodiments, at least 35% of the weekday purchase orders for delivery to residences are made between the hours of 7 am to 5 pm, and at least 50% of the weekday deliveries to residences (same day as purchase order) are made between the hours of 3 pm to 11 pm (as applied to a particular local retail facility and/or system-wide); in some cases, at least 50% of the weekday purchase orders and at least 70% of the weekday deliveries as aforementioned.", "Our invention can offer the convenience of making a purchase order on the night prior for on-demand delivery the next day.", "As such, in some embodiments, at least 15% of the purchase orders for delivery to residences the next day are made between the overnight hours of 5 pm to 12 midnight (as applied to a particular local retail facility and/or system-wide); in some cases, at least 25% of the purchase orders as aforementioned.", "Example Embodiment FIGS.", "8-10 show an example of how our invention might be implemented.", "FIG.", "8 shows the back of a supermarket store (perspective view).", "The front of the store is a conventional walk-in supermarket store.", "There is a vehicle bay 90 where the unmanned delivery vehicle can be parked.", "Employees load the delivery vehicle through the service doors 92.FIG.", "9 shows another view of the back of the supermarket (elevation view with see-through).", "Multiple customer purchase orders have been received.", "The employees have collected the purchased items and put them into delivery packaging (for customer order #1, #2, and so on).", "Some of the purchased items are cold food items.", "These are put into thermally-insulated plastic containers 102 and stored in a refrigerated room 100 (e.g.", "walk-in refrigerator).", "Non-perishable items are put into disposable cardboard boxes 104 and kept at ambient temperatures.", "The customers have been notified that their purchase orders are ready for delivery to the designated destinations.", "The unmanned delivery vehicle 96 is parked in the vehicle bay 90 awaiting a delivery request.", "In FIG.", "10, the customer for purchase order #4 has requested delivery to the customer's home.", "Store employees load purchase order #4 into the delivery vehicle 96.The insulated container for order #4 is loaded into the cold compartment 106 of the vehicle (bottom), which itself is thermally-insulated and electrically refrigerated.", "The cardboard boxes holding the non-perishable items are loaded into the top compartment (no temperature control).", "After loading, the delivery vehicle 96 is sent on its way to the customer's home.", "In transit to the delivery destination, the customer is notified that the delivery is on its way.", "When the unmanned delivery vehicle 96 arrives at the delivery destination, the customer is notified that the delivery vehicle has arrived and is given an access code for opening the cargo compartment of the unmanned delivery vehicle.", "When the customer enters the correct access code (e.g.", "on an external keypad on the unmanned vehicle), the cargo door is unlocked.", "The customer picks-up the delivery packaging and takes them inside home.", "After unpacking the cold food items in the insulated container, the customer returns the insulated container into the cold compartment of the vehicle and closes the cargo door.", "The customer then presses a button on the unmanned vehicle indicating that the delivery is completed.", "With this, the unmanned vehicle returns to the supermarket or makes more deliveries.", "C. Taxi Delivery Service This embodiment of our invention contemplates the use of an autonomous unmanned road vehicle to transport items from a sender to a recipient.", "The sender makes a request for a delivery vehicle (like a request for a taxi) to pick-up an item for delivery to a recipient at a designated delivery location.", "Home Base Facility In this embodiment, the invention uses a home base facility that serves as a place where a fleet of unmanned ground vehicles is kept and maintained.", "The home base facility can be any suitable facility where the vehicles can be maintained, stored, house equipment or personnel involved in the delivery service, and/or house communication equipment for operating the delivery service, etc.", "The home base facility may have personnel and equipment for maintaining the unmanned vehicles, such as battery recharging equipment, replacement batteries, replacement parts, fuel and fueling equipment, repair tools and equipment, etc.", "The home base facility may also have a recovery truck (e.g.", "tow truck or carrier truck) to be dispatched to recover or repair an unmanned vehicle if it experiences problems (e.g.", "loss of battery power, breakdown, traffic collision, vandalism, etc.).", "In some cases, the home base facility is dedicated solely for the taxi delivery service.", "But in other cases, the home base may be located at a business facility that operates a different type of business (other than the delivery service), such as a retail store, office building, gas station, parking garage or parking lot, or school.", "For example, the delivery service may be operated out of a back room, on the parking lot, or from the back alley of the business facility.", "Examples of retail stores where the home base facility could be located include grocery store, supermarket, warehouse store, department store, convenience store, variety store, drug or pharmacy store, electronics store, restaurant, office supply store, hardware or building supply store, etc.", "This is a useful feature because many retail stores already exist in close proximity to residential areas (e.g.", "neighborhood grocery stores).", "The facility for the home base does not have to be newly constructed.", "In some embodiments, the home base is located at an already-established business facility that has been modified to also operate the delivery service but continues to operate the already-existing business (e.g.", "by remodeling, renovation, or other modification of the premises such that it can continue the already-operating business).", "For example, a back room or area of a retail store (e.g.", "grocery store or convenience store) could be converted or renovated to operate the delivery service.", "In another example, the parking lot of a shopping center could be equipped to hold and maintain a fleet of unmanned vehicles, along with other equipment, personnel, and/or housing to operate the delivery service.", "In cases where the home base facility is located at a business facility that also operates a different type of business, there may be some employee staff who are dedicated to the delivery service (e.g.", "maintaining or operating the vehicles).", "However, it may also be possible to have employee(s) who work both the other business operations and also the delivery service.", "As such, in some cases, the business facility operates with at least one employee in at least one work shift working in both the other business operation and the delivery service; and in some cases, at least three employees in at least one work shift who work in this manner.", "In some embodiments, the home base facility is located in an area that is zoned for commercial, industrial, and/or mixed residential-commercial use.", "In some embodiments, the home base facility is located within 6 miles from a residential area, or land that is zoned for residential use, or a residential building (e.g.", "condominium, apartment building, townhouse, rowhouse, detached single-family house, etc.).", "This is a useful feature because many requests may involve delivery to residences.", "In some cases, the home base facility has a covered garage for storing the vehicle(s) when not in use (e.g.", "during idle time or overnight).", "Delivery Request The sender makes a request for transporting one or more items from a location designated by the sender (which may be the sender's own location or another location) to a recipient's location, i.e.", "delivery destination.", "The delivery service of our invention receives the request and assigns one or more of the unmanned ground vehicles for the transportation job.", "The selected vehicle is one that is in relative close proximity to the sender's designated location to provide timely on-demand delivery service.", "Proximity to the sender's designated location may be determined based on any suitable parameter, such as straight-line distance, travel distance, and/or travel time.", "Estimates of proximity may vary depending upon various external factors such as road and traffic conditions, time of day, weather conditions, traffic signal patterns, number of turns required, availability of highways or expressways on the way, etc.", "The selected vehicle may be idle or traveling.", "For example, the selected vehicle may be at the home base facility, parked at a temporary waiting area, or in transit (e.g.", "returning to home base, going to a temporary waiting area, finishing a delivery job, roaming, etc.).", "The selected vehicle is one that is in relative close proximity to the sender's designated location to provide timely on-demand delivery.", "As such, in some embodiments, for greater than 60% of all accepted taxi requests made by senders, the selected vehicle arrives at the sender's designated location within 45 minutes of the sender's taxi request; in some cases, for greater than 75% of all accepted taxi requests.", "These statistical parameters may be applicable to a particular home base facility, particular regional network, and/or system-wide.", "That is, infringement of our patent may occur at the level of particular home base facility(s), particular region(s), or system-wide.", "Here, “all accepted requests” means not counting denied requests (such as prank calls) but encompassing the possibility of delaying incidents, whether expected or unexpected, such as traffic collision, vandalism, road closure, heavy traffic conditions, incorrect or non-existent sender location, inability to access the sender's location (e.g.", "gated community), etc.", "In some embodiments, the sender is a business entity and the recipient is a customer (which may be another business entity or an individual).", "Many types of businesses may be able to use our invention for delivering items to customers, including retail businesses (as described above).", "Many types of items can be delivered using our invention, including consumer and commercial items.", "Examples of consumer items (i.e.", "products that are packaged in a manner intended for the end-user/consumer) that can be delivered include foods, groceries, medical supplies and drugs, propane gas, drinking water, postal packages, office supplies, household products, personal care products, electronic goods, baby care products, clothing/apparel, etc.", "The sender does not have to be a business.", "Our invention can also be used by individuals for delivering personal items (e.g.", "for sending a gift package to a friend).", "In some embodiments, the taxi request includes the recipient's contact information, such as phone number, messaging interface (e.g.", "texting app), email, etc.", "The taxi request can be made in any suitable manner, such as using wired or wireless communication devices (e.g.", "mobile phones), desktop computers, home control panel (for a home automation system), etc.", "The request can be made through any suitable type of interface, such as website with a browser, specialized programs (e.g.", "smartphone apps), telephone menu, an automated system, etc.", "In some cases, the taxi request further includes information about the item being delivered.", "This information can be useful in assigning a suitable vehicle for the delivery task.", "Examples of such useful information include the dimensions of the item, weight of the item, whether it is hot food that needs a heated compartment, or cold food that needs a cooled compartment, etc.", "For example, if the item is a hot food item, a vehicle having a heated compartment can be assigned.", "Or for example, if the item is a cold food item, then a vehicle having a refrigerated compartment can be assigned.", "If the item is relatively small, a smaller vehicle can be assigned, and other such accommodations or optimizations for using the fleet of available vehicles.", "Drive to Sender The unmanned vehicle travels, being driven at least partly in an autonomous manner, to the sender's designated location via a paved roadway.", "The sender may be notified (e.g.", "by the operations hub) that the vehicle is on its way and/or has arrived.", "Upon arrival at the sender's designated location, the vehicle is loaded with the item(s) to be sent.", "After loading the vehicle, the vehicle is made to proceed to the recipient's location.", "This may be accomplished in any suitable manner, such as closing the cargo compartment door and pressing a button indicating that the item has been loaded.", "Drive to Recipient The unmanned vehicle travels, being driven at least partly in an autonomous manner, to the recipient's location via a paved roadway.", "The recipient may be notified that the vehicle is on its way and/or has arrived.", "In some cases, one or more of the packaging used for making the delivery is reusable and intended to be returned to the sender or the home base facility.", "For example, the container holding the cold food items may be designed for reuse.", "The recipient removes the container from the vehicle and unpacks it (e.g.", "move the cold food items into the refrigerator).", "During this time, the vehicle will stand-by until the container is returned to the vehicle.", "After making the delivery, the vehicle may then (1) return to a home base facility; (2) travel to another recipient's location to make another delivery; (3) travel back to the sender's designated location to pick-up another item for delivery; (4) travel to another sender's designated location; or (5) travel to a waiting area as described above.", "Service Operating Area As the vehicle travels from place to place, having the vehicle stay within relatively close proximity to the home base facility can be a useful feature in case the unmanned vehicle experiences problems.", "If the unmanned vehicle becomes disabled, a recovery truck can be dispatched from the home base facility to reach the disabled vehicle quickly.", "As such, in some embodiments, as the unmanned vehicle travels from place to place, the area in which the vehicle operates (operating area) is contained within a 15 mile radius around the home base facility; in some cases, within a 12 mile radius; in some cases, within a 9 mile radius; in some cases, within a 6 mile radius.", "In addition to proximity to the home base facility, the operating area may be planned in consideration of many factors such as the local geography, road layouts, population density, natural and man-made obstacles, traffic patterns, etc.", "Examples of operating areas are shown in FIG.", "11 (A, B, and C), drawn as polygonal shapes.", "In each case, the vehicle's operating area is contained within a radius R around the home base facility HB.", "FIG.", "12 shows an example of how our invention might be implemented.", "The delivery service provider has a fleet of unmanned ground vehicles at the home base facility (HB) that are ready to receive requests for making deliveries.", "Someone at an office building calls a pizza restaurant and places an order for a pizza for delivery to the office location.", "The pizza restaurant begins preparing the pizza and requests a taxi delivery vehicle from the delivery service indicating the office building as the delivery destination and the customer's contact information (e.g.", "cell phone number).", "The delivery service assigns one of the unmanned ground vehicles for this delivery job and is sent to the pizza restaurant.", "The delivery vehicle self-drives to the pizza restaurant and the delivery service notifies the pizza restaurant that the vehicle is on its way.", "When the vehicle arrives at the sender's location, the pizza restaurant may be notified of its arrival.", "One of the pizza restaurant staff loads the customer's pizza into the vehicle's cargo compartment.", "The staff person presses a button on the vehicle indicating that the delivery item is loaded.", "The vehicle then self-drives to the designated office building.", "The delivery service notifies the customer that the vehicle is on its way and/or has arrived (e.g.", "by a text message).", "The delivery service also gives the customer an access code for unlocking the cargo door on the vehicle.", "The customer goes to meet the vehicle and enters the correct access code to open the cargo door to take delivery of the pizza.", "The vehicle then leaves and returns to the home base or proceeds to its next task.", "In this instance, the delivery service has also received a request from a pharmacy to deliver medications to an elderly patient at her residence.", "This same vehicle is determined to be the one in closest proximity and is therefore selected for this next delivery task.", "As instructed, the vehicle self-drives from the office building to the pharmacy and the delivery service notifies the pharmacy that the vehicle is on its way.", "When the vehicle arrives at the pharmacy, the pharmacy may be notified of its arrival.", "One of the pharmacy staff loads the medication into the vehicle's cargo compartment.", "The staff person presses a button on the vehicle indicating that the delivery item is loaded.", "The vehicle then self-drives to the designated customer residence.", "The delivery service notifies the customer that the vehicle is on its way and/or has arrived (e.g.", "by a phone call).", "The delivery service also gives the customer an access code for unlocking the cargo door on the vehicle.", "When the vehicle arrives, the customer (or someone on her behalf) enters the access code and takes the medication.", "The vehicle then leaves and returns to the home base, goes to a waiting area, or proceeds to its next task.", "As the vehicle travels from the home base facility to the pizza restaurant, to the office building, to the pharmacy, and to the patient's residence, the vehicle stays in an operating area that is contained within a 15 mile radius around the home base.", "Regional Delivery Network Our invention can also be implemented over a wider region using multiple home base facilities distributed over a geographic area.", "This feature may be useful for implementing our invention in a metropolitan area (such as the Maryland/Virginia/DC metro area).", "The vehicle may travel from place to place throughout the delivery region while being kept in relatively close proximity to a home base facility.", "As explained above, this can be a useful feature in case the vehicle experiences problems on the road.", "As such, in some embodiments, our invention uses a network of multiple home base facilities in a delivery region.", "The network of home base facilities allows the vehicle to roam throughout the delivery region.", "As such, in some embodiments, each home base facility in the delivery region is within a 9 mile radius of at least one other home base facility; in some cases, within a 6 mile radius; in some cases, within a 3 mile radius.", "In some embodiments, all the home base facilities of the regional network are contained within a circle (e.g.", "as drawn on a map) having a radius of 64 miles; in some cases, 48 miles radius; in some cases, 36 miles radius; in some cases, 24 miles radius; in some cases, 18 miles radius; in some cases, 12 miles radius.", "To keep the vehicle in close proximity to a home base facility, in some embodiments, the overall area in which the vehicle operates is contained within two or more adjoining or overlapping circles that each have a radius of 9 miles around a home base facility; in some cases, each having a radius of 6 miles; in some cases, each having a radius of 3 miles.", "FIG.", "13 shows an example of an operating area for a vehicle.", "The operating area for a particular unmanned vehicle is shown in gray shading.", "The regional delivery network has four home base facilities HB.", "The drawing figure also shows a circle of 9 mile radius centered around each home base facility.", "As shown here, the vehicle's operating area is contained within the four overlapping circles.", "FIG.", "14 shows an example of a regional delivery network.", "The delivery region is defined by the outer dashed line 110 around a geographic region that includes a river and a forest area.", "There are four service areas (designated as numbers 1, 2, 3, and 4) in the region.", "Each service area has one or more home base facilities HB.", "Each home base facility in the delivery region is within a 9 mile radius of at least one other home base facility.", "Moreover, for this regional network, all the home base facilities are contained within a circle having a radius of R. The dashed line inside the delivery region shows an example of a route 112 taken by an unmanned ground vehicle as it takes multiple service calls throughout the day.", "These service calls take the unmanned vehicle from the home base facility in service area 1 into service area 3 and ultimately ends at the home base facility for service area 4.The foregoing description and examples have been set forth merely to illustrate our invention and are not intended to be limiting.", "Each of the disclosed aspects and embodiments of our invention may be considered individually or in combination with other aspects, embodiments, and variations of our invention.", "Modifications of the disclosed embodiments incorporating the spirit and substance of our invention may occur to persons skilled in the art, and such modifications are within the scope of our invention." ] ]
Patent_15872723
[ [ "Spray-Dried Blood Products and Methods of Making Same", "The present invention is directed to a method of preparing dehydrated blood products, comprising the steps of: (a) providing a hydrated blood product; (b) spray-drying the hydrated blood product to produce a dehydrated blood product, as well as dehydrated blood products made by the method.", "The present invention is directed to a method of treating a patient suffering from a blood-related disorder, comprising the steps of: (a) rehydrating a therapeutic amount of the dehydrated blood products to produce a rehydrated therapeutic composition; and (b) administering the rehydrated therapeutic composition to the patient.", "The present invention is directed to a bandage or surgical aid comprising the dehydrated blood products described above." ], [ "1.A method of preparing dehydrated plasma, comprising the steps of: a. providing hydrated plasma; and b. spray-drying said hydrated plasma to produce dehydrated plasma wherein clotting factors are preserved after spray drying.", "2.The method of claim 1, wherein said hydrated plasma is physically or chemically modified.", "3.The method of claim 2, wherein said modification is chemical fixation.", "4.The method of claim 2, wherein said modification comprises additional diagnostic or therapeutic reagents.", "5.The method of claim 4, wherein said diagnostic or therapeutic reagents are selected from the group consisting of imaging agents, concentration factors, performance enhancement drugs, antimicrobial and antiviral reagents, universal donor solutions, and combinations thereof.", "6.Dehydrated plasma made by the method of claim 1.7.A method of treating a patient suffering from a blood-related disorder, comprising the steps of: a. rehydrating a therapeutic amount of the dehydrated plasma blood products of claim 6 to produce a rehydrated therapeutic composition; and b. administering said rehydrated therapeutic composition to said patient.", "8.A bandage or surgical aid comprising the dehydrated plasma of claim 6.9.Spray dried plasma, wherein when said spray dried plasma is rehydrated to form a rehydrated plasma composition, said composition has a turbidity (A500) value less than that of a comparable rehydrated lyophilized composition of plasma." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>In one embodiment, the present invention is directed to a method of preparing dehydrated blood products, comprising the steps of: (a) providing a hydrated blood product; (b) spray-drying the hydrated blood product to produce a dehydrated blood product, as well as dehydrated blood products made by the method.", "In another embodiment, the present invention is directed to a method of treating a patient suffering from a blood-related disorder, comprising the steps of: (a) rehydrating a therapeutic amount of the dehydrated blood products to produce a rehydrated therapeutic composition; and (b) administering the rehydrated therapeutic composition to the patient.", "In another embodiment, the present invention is directed to a bandage or surgical aid comprising the dehydrated blood products described above.", "In yet another embodiment, the present invention is directed to a method of preparing dehydrated fixed blood platelets, comprising the steps of: (a) providing hydrated fixed blood platelets; and (b) spray-drying the hydrated fixed blood platelets to produce a dehydrated fixed blood platelets, as well as dehydrated fixed blood platelets made by the method.", "In yet another embodiment, the present invention is directed to a method of treating a patient suffering from a blood-related disorder, comprising the steps of: (a) rehydrating a therapeutic amount of the dehydrated fixed blood platelets to produce a rehydrated therapeutic composition; and (b) administering the rehydrated therapeutic composition to the patient.", "In yet another embodiment, the present invention is directed to a bandage or surgical aid comprising the dehydrated fixed blood platelets described above.", "In yet another embodiment, the present invention is directed to spray dried fixed blood platelets having spherical-dimpled geometry, wherein when said spray dried fixed blood platelets are rehydrated to form a rehydrated fixed blood platelet composition, the composition has a turbidity (A 500 ) value less than that of a comparable rehydrated lyophilized composition of fixed blood platelets.", "These and other embodiments will become evident on reading the following detailed description of the invention." ], [ "BACKGROUND OF THE INVENTION Field of the Invention The present invention is directed to methods of preparing dried blood products using spray-drying as an alternative to conventional lyophilization (freeze-drying), and products made by the method.", "Using the method of the invention, increased recovery rates of dried product are possible.", "The final product displays at least three-fold concentration over native plasma, as well as increased reconstitution rates when mixed with liquids.", "Brief Description of the Related Art Spray-drying is a technology in which a solution is atomized in a stream of flowing gas for rapid solvent vaporization (e.g., dehydration).", "The result is the formation on a sub-second timescale of microparticles composed of the residual solute.", "Spray-drying has been used as a industrial process in the material,4 food5 and pharmaceutical6,7 industries for decades.", "(e.g., see Bergsoe8 for an earlier review).", "More recently, spray-drying has facilitated the preparation of protein therapeutics as microparticles for inhalation,9 the formulation of advanced carrier-therapeutic microstructures,10-12 and new classes of micromaterials.13-15 The role of kinetic, phase transition, mass transfer, heat transfer, and other physical processes in determining ultimate particle size and composition are well-understood (e.g., see Vehring16 for a recent review), and research in spray-drying is an extremely active area in materials science research.", "An important finding from this body of research is that in aqueous systems the heat of vaporization reduces the temperature of the particles during the volatilization process.", "Thus, thermal denaturation of proteins can be minimized for preservation of protein activities.", "During World War II, the benefits of whole blood transfusion were appreciated, but logistical difficulties related to collection, transport, outdating and typing mismatch for transfusion reactions limited widespread utilization17.Dried plasma was thus developed as a surrogate for whole blood18.American, British and Canadian military transfusion services extensively utilized dried plasma1 during World War II with a very favorable safety profile.", "The methods for preparing U.S. Army-Navy dried plasma were originally scaled to commercial volumes by Sharp and Dohme, Inc. (and later by a larger industrial consortium) with lyophilization technologies analogous to today's freeze-drying protocols19.The dried U.S. Army-Navy plasma was anticoagulated with 0.67% (w/v) sodium citrate, and after 1942 was rehydrated with 0.1% (w/v) citric acid.", "Rehydration with citric acid was found to result in a final product pH of 7.4-7.6 for a more favorable preservation of thrombin generation20.Dried U.S. Army-Navy plasma was placed in widespread civilian use after 1945, and used in the initial phases of the Korean War.", "However, despite nascent development of ultraviolet irradiation microbial decontamination methods21, the production of dried plasma was suspended in 1953, the stated reason being hepatitis contamination.", "However, civilian use of plasma, mostly as fresh frozen plasma, has greatly expanded, with over 13 million units being collected in 200522.In current medical practice plasma is used for a variety of indications, one of the most important being as a component of resuscitation mixtures in trauma with massive blood loss.", "Plasma contains components, such as the coagulation factors and fibrinogen, which are frequently diminished in hemorrhagic shock-related coagulopathies (e.g., see Hardy et al.23).", "Several medical findings point towards the utility of a hyper-concentrated plasma product.", "The desirability of low volume resuscitation, as facilitated by products such as hyper-concentrated plasma, is becoming increasingly accepted since the initial observations of adverse outcomes related to standard resuscitation.24-26 Incidences of transfusion associated cardiac overload and fluid overload-associated acute respiratory distress syndrome might be avoided with low volume resuscitation.27,28 Administration of reduced volumes can also be desirable if ongoing hemorrhage is exacerbating dilutional coagulopathies (e.g.", "see Stern for a review29).", "The development of advanced resuscitation products, such as hemoglobin-based oxygen carriers (HBOCs),30 facilitate the ability to achieve adequate tissue oxygenation without infusion of large volumes of fluids.", "However, the introduction of HBOCs is anticipated to create a need for low volume products to supplement hemostatic systems, such as concentrated plasma.", "Dried blood products are known in the art, and the predominant technique for achieving the dried product is lyophilization (freeze-drying).", "For example, U.S. Pat.", "Nos.", "4,287,087 and 4,145,185 to Brinkhous et al.", "disclose dried blood platelets that have been fixed with a crosslinking reagent such as formaldehyde.", "U.S. Pat.", "Nos.", "5,656,498, 5,651,966; 5,891,393; 5,902,608; and 5,993,804 disclose additional dried blood products.", "Such products are useful for therapeutic purposes because they are stable, have long shelf life, and can be used potentially in powder form to arrest bleeding in patients undergoing severe trauma.", "However, such products must be manufactured under strict sterile conditions in order to avoid contamination.", "With current transfusion practices, plasma is frequently provided as a thawed single donor “fresh frozen” product.", "However, since refrigeration is difficult to provide in forward military applications, underdeveloped countries, and in wilderness medicine situations, this form factor can be logistically problematic.", "Thus, the elimination of freezing (lyophilization) via a dried plasma product would be a significant advantage.", "In addition, the dried plasma product is significantly easier to pathogen reduce than is fresh frozen plasma.", "The present invention is believed to be an answer to that need.", "SUMMARY OF THE INVENTION In one embodiment, the present invention is directed to a method of preparing dehydrated blood products, comprising the steps of: (a) providing a hydrated blood product; (b) spray-drying the hydrated blood product to produce a dehydrated blood product, as well as dehydrated blood products made by the method.", "In another embodiment, the present invention is directed to a method of treating a patient suffering from a blood-related disorder, comprising the steps of: (a) rehydrating a therapeutic amount of the dehydrated blood products to produce a rehydrated therapeutic composition; and (b) administering the rehydrated therapeutic composition to the patient.", "In another embodiment, the present invention is directed to a bandage or surgical aid comprising the dehydrated blood products described above.", "In yet another embodiment, the present invention is directed to a method of preparing dehydrated fixed blood platelets, comprising the steps of: (a) providing hydrated fixed blood platelets; and (b) spray-drying the hydrated fixed blood platelets to produce a dehydrated fixed blood platelets, as well as dehydrated fixed blood platelets made by the method.", "In yet another embodiment, the present invention is directed to a method of treating a patient suffering from a blood-related disorder, comprising the steps of: (a) rehydrating a therapeutic amount of the dehydrated fixed blood platelets to produce a rehydrated therapeutic composition; and (b) administering the rehydrated therapeutic composition to the patient.", "In yet another embodiment, the present invention is directed to a bandage or surgical aid comprising the dehydrated fixed blood platelets described above.", "In yet another embodiment, the present invention is directed to spray dried fixed blood platelets having spherical-dimpled geometry, wherein when said spray dried fixed blood platelets are rehydrated to form a rehydrated fixed blood platelet composition, the composition has a turbidity (A500) value less than that of a comparable rehydrated lyophilized composition of fixed blood platelets.", "These and other embodiments will become evident on reading the following detailed description of the invention.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is an electron micrograph of microspheres of spray-dried plasma produced according to the present invention; FIG.", "2 is a graph showing coagulation factor levels in various samples; FIG.", "3 depicts graphs showing native coagulation pathway turnover with spray dried plasma produced according to the method of the invention; FIG.", "4 is an electron micrograph showing fibrin ultrastructure from spray dried plasma produced according to the method of the invention; FIG.", "5 is a graph depicting the turbidity and rehydration rate of spray-dried vs. lyophilized plasma at several concentrations; FIG.", "6 is an electron micrograph of rehydrated spray-dried derivatized blood platelets; FIG.", "7 is another electron micrograph of rehydrated spray-dried derivatized blood platelets; and FIG.", "8 are electron micrographs illustrating ristocetin agglutination of spray-dried rehydrated platelets made according to the method of the invention.", "DETAILED DESCRIPTION OF THE INVENTION As indicated above, the present invention is directed to methods of preparing dehydrated blood products, and dehydrated blood products made by the method.", "Useful hydrated blood products that may be dehydrated by the method of the invention include, but are not limited to, whole blood, blood plasma, blood platelets, red blood cells, blood serum, plasma, and combinations of these.", "One particularly useful blood product that is suitable for the method of the present invention is blood platelets that have been fixed with a fixative agent, such as formaldehyde or paraformaldehyde.", "Additionally, the blood products may be modified with additional diagnostic or therapeutic agents, such as imaging agents, concentration factors, performance enhancement drugs, antimicrobial and antiviral reagents, universal donor solutions, and the like, as well as combinations of these.", "One example of a useful modified product is STASIX (derivatized dried blood platelets) available from Entegrion, Inc. (Research Triangle Park, NC).", "The technique of spray-drying is used in the method of the invention as an alternative to conventional drying techniques known in the art, such as lyophilization (freeze drying).", "Spray drying is a method of transforming material in a fluid state into a dried particulate form by spraying a feed of a material into a warm drying medium.", "Spray drying involves evaporation of moisture from an atomized feed by mixing the spray and the drying medium in a controlled fashion.", "The drying medium is typically air, although other gases such as nitrogen may also be used.", "The drying proceeds until the desired moisture content is reached in the sprayed particles and the product is then separated from the drying medium.", "The complete process of spray drying basically consists of a sequence of four processes.", "The dispersion can be achieved with a pressure nozzle, a two fluid nozzle, a rotary disk atomizer or an ultrasonic nozzle.", "Selection upon the atomizer type depends upon the nature and amount of feed and the desired characteristics of the dried product.", "The higher the energy for the dispersion, the smaller are the generated droplets.", "The manner in which spray contacts the drying air is an important factor in spray dryer design, as this has great bearing on dried product properties by influencing droplet behavior during drying.", "In one embodiment, the material is sprayed in the same direction as the flow of hot air through the apparatus.", "The droplets come into contact with the hot drying gas when they are the most moist.", "In another embodiment, the material is sprayed in the opposite direction of the flow of hot gas.", "The hot gas flows upwards and the product falls through increasingly hot air into the collection tray.", "The residual moisture is eliminated, and the product becomes very hot.", "This method is suitable only for thermally stabile products.", "In yet another embodiment, the advantages of both spraying methods are combined.", "The product is sprayed upwards and only remains in the hot zone for a short time to eliminate the residual moisture.", "Gravity then pulls the product into the cooler zone.", "This embodiment is particularly advantageous because the product is only in the hot zone for a short time, and is less likely to be affected by heat.", "In the spray drying method, air is mostly used as drying medium, but other gases such as nitrogen may also be used.", "The gas stream is heated electrically or in a burner and after the process exhausted to atmosphere.", "If the heating medium is recycled and reused, typically an inert gas such as nitrogen, is used instead of air.", "Use of nitrogen is advantageous when flammable solvents, toxic products or oxygen sensitive products are processed.", "During the spray drying process, as soon as droplets of the spray come into contact with the drying gas, evaporation takes place from the saturated vapor film which is quickly established at the droplet surface.", "Due to the high specific surface area and the existing temperature and moisture gradients, heat and mass transfer results in efficient drying.", "The evaporation leads to a cooling of the droplet and thus to a small thermal load.", "Drying chamber design and air flow rate provide a droplet residence time in the chamber, so that the desired droplet moisture removal is completed and product removed from the dryer before product temperatures can rise to the outlet drying air temperature.", "Hence, there is little likelihood of heat damage to the product.", "Two systems are used to separate the product from the drying medium.", "First, primary separation of the drying product takes place at the base of the drying chamber, and second, total recovery of the dried product in the separation equipment.", "In one embodiment, a cyclone is used to collect the material.", "Based on inertial forces, the particles are separated to the cyclone wall as a down-going strain and removed.", "Other systems such as electrostatic precipitators, textile (bag) filters or wet collectors like scrubbers, may also be used to collect the dried product.", "As used in the present invention, spray drying offers advantages over other drying methods such as lyophilization (freeze drying).", "Use of spray drying produces a product that is more consistent, less clumpy, and better dispersed than freeze drying methods.", "The highly dispersed particles produced by spray drying also allow for a rapid rehydration rate, which is likely a result of a larger available surface area.", "By contrast, the clumped nature of a freeze dried product, results in substantially longer rehydration times for the blood products that are dried in the method of the invention.", "Since many transfusions and other uses of blood products can be highly time-sensitive, this higher rate of rehydration can be a significant advantage in battlefield or emergency treatment situations.", "As explained in more detail below, spray dried fixed blood platelets of the invention can be rehydrated to form a rehydrated fixed blood platelet composition, and the composition has a turbidity (A500) value less than that of a comparable rehydrated lyophilized composition of fixed blood platelets.", "The spray-dried products of the method of the invention may be used as topical treatments in treating wounds.", "In one embodiment, the products may be used directly on a wound to assist clotting, or may be applied to a bandage or surgical aid or covering to assist in wound healing.", "In an alternative embodiment, the rehydrated forms of the spray-dried products of the method of the invention may be administered via intravenous injection as therapeutic treatments to patients afflicted with blood-related disorders such as thrombocytopenia (including washout thrombocytopenia), hemorrhagic platelet dysfunction, and trauma victims experiencing severe bleeding.", "EXAMPLES General Design and Methods Spray-dried Plasma Concentration.", "Human pooled solvent-detergent treated plasma (Kedrion S.p.A., Barga, Italy) and porcine plasma from a pool of ten animals (donated by the Francis Owen Blood Research Laboratory, University of North Carolina at Chapel Hill) can be spray-dried over a range of instrumental run parameters or freeze-dried with a standard lyophilization cycle to obtain different sized dehydrated microparticles.", "The products are then rehydrated with different volumes of sterile water that contain a low concentration of glycine at pH=2.4 to compensate for the loss of protons during the dehydration process and compared to establish the upper limit for concentration.", "Details of the experiments follow: Plasma dehydration.", "Porcine and human plasma can be spray-dried in a Buchi B-270 research spray-dryer at a flow rate of 415 liters N2 per hour at 140° C., 130° C., 120° C., 110° C., and lower if dehydration can be obtained.", "Runs are preferably performed three times at each temperature and with each type (i.e., porcine and human) plasma.", "The final product can be analyzed for moisture content and microparticles imaged with scanning electron microscopy.", "Portions of pig and human plasma may also be lyophilized at −20° C. for three days from a 4 mm layer to obtain a “lyophilization control” cake.", "As shown in the accompanying Figures, spray-dried material is observed to be a fine powder, and appear as microspheres under the microscope, while lyophilized material forms a cake.", "Plasma rehydration.", "Spray-dried and lyophilization control lots (each in triplicate) are rehydrated with the appropriate volume of sterile water with glycine for 1×, 2×, 3×, 4× and possibly higher hyper-concentration of the plasma.", "Rehydration can be with glycine solutions at pH=2.4 for a product with a final rehydrated pH=7.4 as follows: 1×-20 mM glycine, 2×-40 mM glycine, 3×-60 mM glycine, 4×-80 mM glycine, etc.", "Physical and chemical analysis.", "The following analysis may be performed with each triplicate sample of starting plasma (pre-spray dry), each lot spray-dried material and the lyophilized control plasma.", "Comparisons can be made with the Wilcoxon Signed Rank Test, and directionality will be assessed using the Sign test.", "Turbidity and rate of solubilization—Optical measurement of the light absorption at 700 nm can assess turbidity as a function of time after initiation of the rehydration reaction.", "Viscosity can be estimated with a falling ball viscometer.", "Coagulation factor levels (including FII, FV, FVII, FVIII, FIX, FX, FXII, FXII, FXIII, protein S, protein C, von Willebrand factor) are measured with ELISA analysis.", "Coagulation pathway turnover—Prothrombin times and activated partial thromboplastin times are measured with concentrated plasmas after dilution of the hyper-concentrated solutions to 1×.", "Final clots are examined with scanning electron microscopy to assess fiber thickness and density.", "A concentrated solution preferably will have the appropriate rheology for standard transfusion practice in which coagulation factor levels and activities are within normal intra- and inter-individual ranges of variation.", "This solution can be utilized for the “most concentrated” infusions in porcine studies described below.", "Safety evaluation of concentrated plasma products in pigs.", "The goal of these studies is to identify a maximum tolerated dose for hyper-concentrated plasma preparations in injured pigs.", "Animals are subjected to hepatic injuries for blood loss and induction of compensated hemorrhagic shock.", "Animals are then be infused with hyper-concentrated plasma porcine preparations until an adverse hemodynamic response is noted.", "At the termination of the experiment animals is sacrificed and subjected to post-mortem analysis for histological evidence of prothrombotic complications.", "The endpoint of this analysis will be the definition of the relationship between maximum tolerated dose and degree of plasma concentration.", "Induction of Shock in Pigs and Infusion of hyper-concentrated plasma.", "40 to 50 kg pigs (obtained from the Division of Laboratory Animal Medicine (UNC) breeding colony) are anesthetized.", "Analysis of hemodynamic and vasoactive processes.", "Several sensors are placed to follow hemodynamic and vasoactive processes: a pulmonary artery thermo dilution catheter is inserted via the external jugular vein into a pulmonary artery; micromanometer-tipped catheters are positioned via the left femoral vessels into the right atrium and thoracic aorta; a 0.22 gauge catheter is inserted into the left femoral artery and connected to a withdrawal pump.", "Patterns of blood flow are measured by placing Doppler flow probes on the cephalic and mesenteric arteries; this procedure can be supported by carotid artery cut down and laparotomy.", "Induction of shock and infusion of hyper-concentrated plasma.", "Hemorrhagic shock can be induced by withdrawing 40% of total blood volume over a one-hour period.", "After withdrawal of blood and verification of hemorrhagic shock (mean arterial blood pressure <40 mm Hg, shift in cephalic, splanchnic blood flow pattern), the animals are infused with multiple doses of 1× spray-dried plasma or hyper-concentrated spray-dried plasma at an intermediate and high level of concentration (to be determined as described above).", "Each infusion is preferably a volume equivalent to 1/10th of the animal's blood volume, and is preferably performed over a three minute period with a Harvard syringe pump.", "Hemodynamic and other physiological parameters can be measured, and infusions can be stopped when two successive boluses result in worsening hemodynamic stability.", "Animals are then be sacrificed for autopsy and histological analysis.", "The number of animals and the infused products used in this Example are shown in Table 1.TABLE 1 Infused Product Number of Animals 1x Plasma 3 Intermediate Concentration (e.g., 2x) 3 High Concentration (e.g., 4x) 3 Total Animals 9 Microvasculopathologies and hemolytic disorders.", "After sacrifice, selected renal, hepatic, pulmonary, splenic, lung and other tissue are prepared for light microscopic analysis.", "The histological analysis focuses on identifying signs of macroscopic or disseminated intravascular coagulation or premature induction of selected organ failure.", "Data analysis.", "Comparisons between plasma groups are made with the Wilcoxon Signed Rank Test, and directionality assessed using the Sign test.", "Example 1: Spray-Drying of Plasma and Preservation of Coagulation Protein Activities The following series of experiments demonstrate that plasma can be spray-dried to obtain dehydrated microparticles, and then rehydrated to the original volume for plasma with native coagulation factor levels and coagulation parameters.", "Solvent-detergent pooled plasma was subjected to standard spray-drying (415 liters N2 per hour at 120° C. in Butchi, Inc. B-270) to obtain the product depicted in FIG.", "1.The spherical-dimpled geometry of the resulting microparticles is similar to the shapes obtained when other proteins are spray-dried, indicating that a protein surface shell forms as a result of the initial kinetics of water removal and concentration (e.g., see Vehring16).", "However, this geometry is distinctive over lyophilized plasma which displays a jagged surface texture.", "Upon rehydration with 20 mM glycine, pH=2.4 to compensate for proton loss during the drying process for the original protein concentration, the coagulation factor levels were found to be essentially the same as in the original plasma before spray drying as shown in FIG.", "2.Spray-drying also had an insignificant effect on the kinetics of plasma coagulation (FIG.", "3).", "There was a statistical trend (that was not significant in this analysis) towards enhanced coagulation protein molecular turnover after spray-drying, an effect that might be related to differences in the association states of proteins in plasma samples.", "The fibrin strands after spray-dried plasma fibrinogen polymerization had normal morphology (FIG.", "4).", "In contrast to the methods of the present invention, freezing and lyophilized plasma results in a product that contains microscopic and macroscopic domains of varying composition due to phase separation.", "The result is that rehydration at super-physiological concentrations is time consuming and results in a turbid suspension.", "This point is demonstrated by the data presented in FIG.", "5 which shows A500 (turbidity) for several concentrations of rehydrated plasma.", "The solvent-detergent treated plasma product was subjected to spray-drying or lyophilization, then rehydrated for native (1×), 2×, 3× or 4× final concentration.", "Rehydration times, based on the time for macroscopic dissolution to occur, was dramatically faster with the spray-dried material due to the massive surface area of the microparticle formulation, and results in a significantly less turbid suspension as shown by lower A500 values in FIG.", "5.In addition to the plasma described above, other blood products may be dried and rehydrated in accordance with the description above.", "Virtually any treated or untreated blood product may be used in the method of the invention.", "Examples of blood products include whole blood, blood plasma, blood platelets, red blood cells, blood serum, as well as combinations of these.", "The blood products may be used in the method of the invention in their naturally occurring state, or may be modified in any way.", "Examples of modifications of these blood products include fixation with a fixing agent such as formaldehyde or paraformaldehyde as described in U.S. Pat.", "Nos.", "5,651,966; 5,891,393; 5,902,608; and 5,993,804; addition of imaging agents, concentration factors, performance enhancement drugs, antimicrobial and antiviral reagents and universal donor solutions.", "One example of a useful modified product is STASIX (derivatized dried blood platelets) available from Entegrion, Inc. (Research Triangle Park, NC).", "The following is a general protocol for rehydration of spray-dried STASIX particles.", "Example 2: Rehydration of Spray Dried Derivatized Blood Platelets The goal of this example is to rehydrate spray-dried derivatized blood platelets (sold under the tradename STASIX and available from Entegrion, Inc., NC) so that the concentration of all components (platelet particles, buffer salts, bulking agents (e.g., human serum albumin)) are the same as the suspension that went into the spray-drier.", "This was achieved in three stages.", "First, a “reference A280 value” for the bulking medium used for the pre-spray-dried suspension is obtained.", "This is an A280 nm value for the pre-spray-dry after the platelets are spun out, reflecting the supernatant protein concentration, which is largely human serum albumin bulking agent.", "Second, a trial rehydration with the post-spray-dried powder is performed at 10% (w/v), then the optical density at 280 nm (A280) of the bulking agent (human serum albumin) is measured.", "Third, the pre-spray-dried supernatant A280 and 10% supernatant A280 values are compared (ratioed) to determine how far off the 10% rehydration approximation was.", "This ratio is then used to calculate the exact weight percentage of dried powder that is needed to match the bulking agent protein concentration of the pre-spray dried suspension.", "The platelet count of the post-rehydration particles are then measured two ways.", "First with a Hiska cell counter and second by measuring the optical turbidity.", "These values, and related rehydration volumes, form the starting point for all the particle characterization assays.", "Procedure 1.Measure the optical density of the pre-spray dry to obtain the reference A280 value.", "a) Thaw the liquid pre-spray dry sample and spin out the particles by centrifuging on a desktop microfuge at a setting of five for two minutes.", "Retain the supernatant.", "b) Dilute the supernatant 1/10 into citrated saline in triplicate and measure A280 values with the nanodrop spectrometer.", "2.Measure protein optical density of 10% (w/v) suspension a) Weigh out several (approximately 4) 20-50 mg particle portions in microfuge tubes.", "Record the mass.", "Rehydrate one tube with distilled water for a 10% (w/v) suspension.", "Save the remaining tubes for future analysis.", "b) Spin out particles as above and retain supernatant.", "c) Dilute each rehydrated sample supernatant 1/10 into citrated saline in triplicate and measure the A280 values.", "3.Calculate the rehydration weight percentage to match the pre-spray dried value as follows.", "a) Divide the A280 values from the diluted pre-spray dry supernatant by the dilution factor (1/10) and average the three values to obtain a theoretical reference A280 value or A280, ref.", "b) Divide the A280 values form the 10% rehydration supernatant by the dilution factor (1/10) and average the three values to obtain a theoretical undiluted A280 value, referred to as A280, 10%.", "c) Ratio A280, 10% to the A280, ref value according to Equation 1 to obtain the proper rehydration mass (w/v) of post spray-dry powder so that the rehydrated sample will have the same A280 value as the reference A280 value.", "Weight percentage (w/v)*=10% (w/v)×A280,ref/A250,10% (Equation 1) weight percentage can be in units of mg/ml, e.g., 8.9% (w/v) is equivalent to 89 mg/ml.", "Measurement of STASIX Particle Counts a) Dilute the 10% rehydration suspension (don't perform the cell spin out) 1/10 with citrated saline in triplicate.", "b) Measure the turbidity at A500 of each sample.", "c) Measure the direct cell count with the Hiska hematological analyzer.", "d) Calculate and factor in yield loss.", "Electron micrographs of rehydrated spray-dried derivatized blood platelets (rehydrated STASIX) are shown in FIG.", "6 and FIG.", "7.Example 3: Single Dose Range-Finding Intravenous Toxicity Study in Cynomolgus Monkeys A study was designed to assess the toxicity of spray-dried derivatized dried blood platelets (spray-dried Stasix as described above, then rehydrated) when administered via intravenous infusion (over approximately 5 minutes) to monkeys as a single dose.", "A recovery subgroup of the animals was observed for 7 days.", "Five groups of monkeys were used—Group 1—vehicle (buffer) control; Group 2—1× therapeutic STASIX dose; Group 3—5× therapeutic STASIX dose; Group 4-10× therapeutic STASIX dose; and Group 5—human serum albumin (500 mg/kg).", "Dosages were respectively 0.0, 2.1×109, 1.05×1010, 2.1×1010, and 0.0 platelets/kg in group 1, 2, 3, 4, and 5.A 1× dose is the estimated therapeutic STASIX dose in a human patient, i.e., an additional 30,000 platelet particles per microliter of blood.", "No adverse effects either symptomatic or micro-pathologic were seen in any of the monkeys used in this experiment.", "Since 2 male monkeys and 2 female monkeys all tolerated a 10× therapeutic dose of STASIX infused over the very brief time period of only 5 minutes, the no observable adverse effect level (NOAEL) is at least 10× the therapeutic dose.", "In a human clinical setting, STASIX doses would be infused at a much slower time rate of 20 minutes.", "Necropsy of the 14 study monkeys comprising the 5 dosing groups was conducted at either Day 2 or Day 8 following infusion, and showed no evidence of the development of microthrombi in either the heart or lungs.", "In summary, in a detailed animal study conducted by a major outside research laboratory under all appropriate animal use and handling regulations, STASIX was shown to display no harmful effects at either a macroscopic or microscopic level at doses up to 10 times the intended human therapeutic dose.", "Example 4: Spray-Drying of Aldehyde Stabilized Platelets The utility of spray-drying as an alternative to lyophilization for the dehydration of aldehyde-stabilized platelets is examined in this example.", "Human apheresis platelets were stabilized using the procedure of Read et al.", "described in U.S. Pat.", "No.", "5,651,966, which is herein incorporated by reference in its entirety.", "Spray-drying (415 liters N2 per hour at 120° C.) of the final aldehyde-stabilized platelet suspension at 2.0 million platelets/microliter in 5% (w/v) human serum albumin as described above resulted in a fine powder that, upon examination, consisted of spherical particles with 3 to 30 micron diameters similar to those shown in FIGS.", "6 and 7.Seventeen independent dried platelet preparations were prepared with spray-drying and then rehydrated for the original pre-dehydration volumes.", "The yield (post-rehydration/pre-spray drying) of countable platelets was 96.8%+/−7.0% (standard deviation) for these seventeen runs.", "FIG.", "8 depicts spray-dried platelets after rehydration, exchange into normal human plasma (as a von Willebrand factor source) and addition of ristocetin to 1 mg/ml (Panel B) or a corresponding volume of control buffer (Panel A).", "Large aggregates were noted with ristocetin addition, indicating that spray-drying preserved glycoprotein 1B—von Willebrand factor receptor functions.", "Cynomolgus monkeys (1 or 2/sex/group) received a single 5-minute intravenous infusion of the spray-dried platelets at doses of 2.1×109, 1.05×1010, or 2.1×1010 platelets/kg.", "Control animals (2/sex) received vehicle (5.375 mM sodium citrate and 2 mM cysteine in physiological saline) and an additional group received 500 mg/kg human serum albumin (HSA).", "The dose volume was 2 mL/kg/min for all groups.", "Animals were observed for 1 or 7 days post-dose.", "One day after dose administration, 1 animal/sex/group was euthanized and necropsied.", "One animal per sex from the control and high-dose (2.1×1010 platelets/kg) groups were held for 7 days prior to necropsy.", "Parameters evaluated during the study were viability, clinical observations, body weights, clinical pathology (pretest, day 2 and day 8), organ weights, macroscopic observations and microscopic pathology.", "Administration of all doses of spray-dried platelets (up to 2.1×1010 platelets/kg) was well tolerated.", "Hematology changes were limited to a decrease in the number of platelets and an increase in mean platelet volume in one of the two high-dose (2.1×1010 platelets/kg) animals (the female) on the day following dose administration.", "There were no observed changes in coagulation or clinical pathology parameters.", "Increases in spleen weight, relative to control values, were seen in all test article- and HSA-treated animals.", "Microscopic observations showed slight to moderate increases in the size of germinal centers in the spleen in mid- and high-dose (1.05×1010 or 2.1×1010 platelets/kg) females and the HSA-treated female on day 2 and the high-dose female (only group necropsied) on day 8 that correlated with macroscopic observations of tan discoloration and surface abnormalities of the spleen in some animals.", "Germinal center enlargement in females was considered a possible response to HSA.", "Similar findings were not seen in the vehicle treated control, which had smaller germinal centers.", "However, because active germinal centers are a common finding in monkey spleens, and because the sample size was small, this finding may be within normal background range.", "The persistence of splenic germinal center enlargement after 7 days in one animal suggests lack of recovery, which would be consistent with germinal center reaction to antigenic stimulation, but this finding may also reflect normal background variation.", "Example 5—Spray-Drying of Plasma and Testing in Pigs— Plasma separated from fresh porcine blood was either stored as fresh frozen plasma (FFP) or preserved as freeze dried plasma (FDP) or spray-dried plasma (SDP, prepared as detailed in previous examples).", "For in-vitro testing: SDP was reconstituted in distilled water which was either equal (1×SDP) or one-third (3×SDP) the original volume of FFP.", "Analysis included measurements of prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen levels, and activity of selected clotting factors.", "For in-vivo testing swine were subjected to polytrauma (femur fracture, grade V liver injury) and hemorrhagic shock (60% arterial hemorrhage, with the “lethal triad” of acidosis, coagulopathy and hypothermia), and treated with FFP, FDP, or 3×SDP (n=4-5/group).", "Coagulation profiles (PT, PTT, thromboelastography) were measured at baseline (BL), post-shock (PS), post crystalloid (PC), treatment (MO), and during 4 hours of monitoring (M 1-4).", "In-vitro testing revealed that clotting factors were preserved after spray-drying.", "The coagulation of FFP and 1×SDP were similar, with 3×SDP showing a prolonged PT/PTT.", "Polytrauma/hemorrhagic shock produced significant coagulopathy, and 3×SDP infusion was as effective as FFP and FDP in reversing it.", "These results show that plasma can be spray-dried, and reconstituted to one-third its original volume without compromising the coagulation properties in-vivo.", "This shelf-stable, low-volume, hyperoncotic, hyperosmotic plasma is a logistically attractive option for the treatment of trauma-associated and other coagulopathies.", "REFERENCES 1.Kendrick, B. G. D. B.", "Blood Program in World War II.", "U.S. Government Printing Office Library of Cong.", "Cat.", "No.", "64-60006, http://amedd.mil/booksdoc/wwii/blood/default.htm (1964).", "2.Ketchum, L., Hess, J. R. & Hiippala, S. Indications for early fresh frozen plasma, cryoprecipitate, and platelet transfusion in trauma.", "The Journal of trauma 60, S51-58 (2006).", "3.Erber, W. N. & Perry, D. J.", "Plasma and plasma products in the treatment of massive haemorrhage.", "Best Pract Res Clin Haematol 19, 97-112 (2006).", "4.Smith, M. W. Spray-drying synthetic detergents.", "Manufacturing chemist and aerosol news 22, 186-187 (1951).", "5.Heldman, D. R., Hall, C. W. & Hedrick, T. I.", "Air filtration for the spray drying of dairy products.", "Journal of dairy science 51, 466-470 (1968).", "6.Raff, A. M., Robinson, M. J.", "& Svedres, E. V. Spray-drying of tablet granulations.", "I.", "A preliminary report.", "Journal of pharmaceutical sciences 50, 76-79 (1961).", "7.Riegelman, S., Swintosky, J. V., Hiquchi, T. & Busse, L. W. Studies on pharmaceutical powders and the state of subdivision.", "IV.", "The application of spray-drying techniques to pharmaceutical powders.", "Journal of the American Pharmaceutical Association 39, 444-450 (1950).", "8.Bergsoe, C. Progress in spray-drying.", "Manufacturing chemist and aerosol news 20, 72-75 (1949).", "9.Maltesen, M. J., Bjerregaard, S., Hovgaard, L., Havelund, S. & van de Weert, M. Quality by design—Spray drying of insulin intended for inhalation.", "Eur J Pharm Biopharm 70, 828-838 (2008).", "10.Borghetti, G. S., Lula, I. S., Sinisterra, R. D. & Bassani, V. L. Quercetin/beta-Cyclodextrin Solid Complexes Prepared in Aqueous Solution Followed by Spray-drying or by Physical Mixture.", "AAPS PharmSciTech (2009).", "11.Mohammed, G. A., Puri, V. & Bansal, A. K. Coprocessing of nevirapine and stavudine by spray drying.", "Pharmaceutical development and technology 13, 299-310 (2008).", "12.Ochiuz, L. & Peris, J. E. Preparation and characterisation of alendronate-loaded chitosan microparticles obtained through the spray drying technique.", "Medicinal chemistry (Shariqah (United Arab Emirates)) 5, 191-196 (2009).", "13.Iskandar, F. et al.", "Production of morphology-controllable porous hyaluronic acid particles using a spray-drying method.", "Acta biomaterialia (2008).", "14.Sen, D. et al.", "Evaporation Driven Self-Assembly of a Colloidal Dispersion during Spray Drying: Volume Fraction Dependent Morphological Transition.", "Langmuir (2009).", "15.Zhang, X. et al.", "Preparation of a dispersible PEGylate nanostructured lipid carriers (NLC) loaded with 10-hydroxycamptothecin by spray-drying.", "Chemical & pharmaceutical bulletin 56, 1645-1650 (2008).", "16.Vehring, R. Pharmaceutical particle engineering via spray drying.", "Pharmaceutical research 25, 999-1022 (2008).", "17.Churchhill, C. Surgery in World War II.", "The physiologic effects of wounds.", "U.S. Government Printing Office (1952).", "18.Blalock, A.", "Report on Committee on Transfusion, National Research Council.", "(1940).", "19.Harper, S. B.", "The preparation and experimental use of dried blood plasma.", "Proceedings of Staff Meetings of the Mayo Clinic 15, 689-694 (1940).", "20.Strumia, D. Minutes, meeting of subcommittee on blood substitutes.", "Division of Medical Sciences, National Research Council (1942).", "21.Allen, J., Enerson, D., Barron, E. and Sykes, C. Pooled plasma with little or no risk of homologous serum Jaundice.", "J.", "A. M. A.", "152, 1421-1423 (1954).", "22.Whitaker, B. a. S., M. The 2005 Nationwide Blood Collection and Utilization Survey Report.", "AABB and US Dept.", "HHS http://www.aabb.org./apps/docs/05nbcursrpt.pdf (2005).", "23.Hardy, J. F., De Moerloose, P. & Samama, M. Massive transfusion and coagulopathy: pathophysiology and implications for clinical management.", "Can J Anaesth 51, 293-310 (2004).", "24.Baxter, C. R. & Shires, T. Physiological response to crystalloid resuscitation of severe burns.", "Annals of the New York Academy of Sciences 150, 874-894 (1968).", "25.Shires, T. Initial care of the injured patient.", "The Journal of trauma 10, 940-948 (1970).", "26.Shires, T., Coln, D., Carrico, J.", "& Lightfoot, S. Fluid Therapy in Hemorrhagic Shock.", "Arch Surg 88, 688-693 (1964).", "27.Skeate, R. C. & Eastlund, T. Distinguishing between transfusion related acute lung injury and transfusion associated circulatory overload.", "Current opinion in hematology 14, 682-687 (2007).", "28.Triulzi, D. J. Transfusion-related acute lung injury: current concepts for the clinician.", "Anesthesia and analgesia 108, 770-776 (2009).", "29.Stern, S. A. Low-volume fluid resuscitation for presumed hemorrhagic shock: helpful or harmful?", "Current opinion in critical care 7, 422-430 (2001).", "30.Reynolds, P. S., Barbee, R. W., Skaflen, M. D. & Ward, K. R. Low-volume resuscitation cocktail extends survival after severe hemorrhagic shock.", "Shock (Augusta, Ga. 28, 45-52 (2007).", "31.Fischer, T. H., Merricks, E., Raymer, R., Nichols, T., Hayes, P., Bode, A., Pearce, L. and Manning, J.", "The co-infusion of rehydrated lyopholized platelets wth HBOC-201 for hemostasis in dilutional thrombocytopenia.", "Blood 98, 2250 (2001).", "32.Manning, J. E. et al.", "Selective aortic arch perfusion using serial infusions of perflubron emulsion.", "Acad Emerg Med 4, 883-890 (1997).", "33.Manning, J. E. et al.", "Selective aortic arch perfusion during cardiac arrest: enhanced resuscitation using oxygenated perflubron emulsion, with and without aortic arch epinephrine.", "Ann Emerg Med 29, 580-587 (1997).", "34.Manning, J. E. et al.", "Selective aortic arch perfusion with hemoglobin-based oxygen carrier-201 for resuscitation from exsanguinating cardiac arrest in swine.", "Critical care medicine 29, 2067-2074 (2001).", "35.Toung, T., Reilly, P. M., Fuh, K. C., Ferris, R. & Bulkley, G. B. Mesenteric vasoconstriction in response to hemorrhagic shock.", "Shock (Augusta, Ga. 13, 267-273 (2000).", "36.Brummel-Ziedins, K., Vossen, C. Y., Rosendaal, F. R., Umezaki, K. & Mann, K. G. The plasma hemostatic proteome: thrombin generation in healthy individuals.", "J Thromb Haemost 3, 1472-1481 (2005).", "37.Budowsky, E., Ackerman, S., Purmal, A., Edson, C., Williams, M. Methods and compositions for inactivating viruses.", "U.S. Pat.", "No.", "6,369,048 (2002).", "38.Burnouf, T. et al.", "Nanofiltration of single plasma donations: feasibility study.", "Vox Sang 84, 111-119 (2003).", "39.Burnouf-Radosevich, M., Appourchaux, P., Huart, J. J.", "& Burnouf, T. Nanofiltration, a new specific virus elimination method applied to high-purity factor IX and factor XI concentrates.", "Vox Sang 67, 132-138 (1994).", "40.Horowitz, B. a. C., S. Removal of antibodies from blood-derived compositions while retaining coagulation factors.", "U.S. Pat.", "No.", "5,541,294 (1996).", "41.Bakaltcheva, I., O'Sullivan, A. M., Hmel, P. & Ogbu, H. Freeze-dried whole plasma: evaluating sucrose, trehalose, sorbitol, mannitol and glycine as stabilizers.", "Thrombosis research 120, 105-116 (2007).", "42.MacLennan, S. & Williamson, L. M. Risks of fresh frozen plasma and platelets.", "The Journal of trauma 60, S46-50 (2006).", "43.Solheim, B. G. Universal pathogen-reduced plasma in elective open-heart surgery and liver resection.", "Clin Med Res 4, 209-217 (2006).", "44.Noddeland, H. et al.", "Universal solvent/detergent-treated fresh frozen plasma (Uniplas-rationale and clinical properties.", "Thrombosis research 107 Suppl 1, S33-37 (2002).", "45.Medwatch, F. Imporrtant safety information regarding Plas+SD.", "http://www.fda.gov/medwatch/safety/2002/plassd_deardoc.pdf (2002).", "46.Monroe, D. M., Hoffman, M., Allen, G. A.", "& Roberts, H. R. The factor VII-platelet interplay: effectiveness of recombinant factor VIIa in the treatment of bleeding in severe thrombocytopathia.", "Seminars in thrombosis and hemostasis 26, 373-377 (2000).", "47.Monroe, D. M., Hoffman, M. & Roberts, H. R. Platelets and thrombin generation.", "Arterioscler Thromb Vasc Biol 22, 1381-1389 (2002).", "48.Deveras, R. A.", "& Kessler, C. M. Reversal of warfarin-induced excessive anticoagulation with recombinant human factor Vila concentrate.", "Annals of internal medicine 137, 884-888 (2002).", "49.Freeman, W. D. et al.", "Recombinant factor VIIa for rapid reversal of warfarin anticoagulation in acute intracranial hemorrhage.", "Mayo Clin Proc 79, 1495-1500 (2004).", "50.Sorensen, B., Johansen, P., Nielsen, G. L., Sorensen, J. C. & Ingerslev, J.", "Reversal of the International Normalized Ratio with recombinant activated factor VII in central nervous system bleeding during warfarin thromboprophylaxis: clinical and biochemical aspects.", "Blood Coagul Fibrinolysis 14, 469-477 (2003).", "51.Talkad, A., Mathews, M., Honings, D., Jahnel, J.", "& Wang, D. Reversal of warfarin-induced anticoagulation with factor Vila prior to rt-PA in acute stroke.", "Neurology 64, 1480-1481 (2005)." ] ]
Patent_15872727
[ [ "HIGH DENSITY OUTER LAYER OF A GOLF CLUB HEAD", "Embodiments of a golf club head comprising a body having a body material density, a strike face having a strike face material density, and a coating comprising a coating material having a coating material density greater than the body material density or the strike face material density are described herein." ], [ "1.A golf club head comprising: a body comprising a body material having a body material density, the body including: a crown, a sole opposite the crown, a heel, a toe opposite the heel, and a back end; a strike face made of a strike face material having a strike face material density; an outer surface; an inner surface; and a coating positioned directly on and in contact with the outer surface of a portion of the sole near a center region of the back end of the club head; and wherein the coating consisting of a coating material having a coating material density, wherein the coating material density is greater than the body material density, the coating material density is between 150 and 400 g/in3, and the body material comprises titanium.", "2.The golf club head of claim 1, wherein the strike face material is the same as the body material, and the coating material is different than the strike face material and the body material.", "3.The golf club head of claim 1, wherein the strike face material is different than the body material, and the coating material is different than the strike face material or the body material.", "4.The golf club head of claim 1, wherein the coating is positioned on the outer surface of the club head on at least a portion of the crown, the sole, the heel, the toe, the strike face, the back end, or the hosel.", "5.The golf club of claim 1, wherein the coating further comprises a surface area ranging from approximately 0-70 in2.6.The golf club of claim 1, wherein the coating further comprises a thickness ranging from approximately 0.00001-0.10 inches.", "7.The golf club of claim 1, wherein the weight of the coating ranges from approximately 1-15 grams.", "8.The golf club head of claim 1, wherein the coating comprises cobalt beryllium copper, pure palladium, tungsten carbide, tungsten rhenium, or pure tungsten.", "9.The golf club head of claim 1, wherein the coating covers over a weight pad or a weight member of the golf club head.", "10.The golf club head of claim 1, wherein the coating material density is between 175 and 400 g/in3.11.A golf club head comprising a body comprising a body material having a body material density, the body including: a crown, a sole opposite the crown, a heel, a toe opposite the heel, and a back end; a strike face made of a strike face material having a strike face material density; an outer surface; an inner surface; and a coating positioned directly on and in contact with the outer surface of a first portion of the sole and a second portion of the sole; wherein, the first portion covers an area of the sole between the toe and the rear end, and the second portion covers an area of the sole between the heel and the rear end; and wherein the coating consisting of a coating material having a coating material density, wherein the coating material density is greater than the body material density, the coating material density is between 150 and 400 g/in3, and the body material comprises titanium.", "12.The golf club head of claim 11, wherein the strike face material is the same as the body material, and the coating material is different than the strike face material and the body material.", "13.The golf club head of claim 11, wherein the strike face material is different than the body material, and the coating material is different than the strike face material or the body material.", "14.The golf club head of claim 11, wherein the coating is positioned on the outer surface of the club head on at least a portion of the crown, the sole, the heel, the toe, the strike face, the back end, or the hosel.", "15.The golf club of claim 11, wherein the coating further comprises a surface area ranging from approximately 0-70 in2.16.The golf club of claim 11, wherein the coating further comprises a thickness ranging from approximately 0.00001-0.10 inches.", "17.The golf club of claim 11, wherein the weight of the coating ranges from approximately 1-15 grams.", "18.The golf club head of claim 11, wherein the coating comprises cobalt beryllium copper, pure palladium, tungsten carbide, tungsten rhenium, or pure tungsten.", "19.The golf club head of claim 11, wherein a perimeter of the coating abuts a weight pad or a weight member of the golf club head.", "20.The golf club head of claim 11, wherein the coating material density is between 175 and 400 g/in3." ], [ "<SOH> BACKGROUND <EOH>Golf club heads may include wood-type club heads (e.g., drivers and fairway woods), iron-type club heads (e.g., irons and wedges), and putter-type club heads.", "Golf club head designs vary and generally aim to optimize head center of gravity position and increase club head moment of inertia.", "The head center of gravity position affects performance characteristics of the golf club including direction, trajectory, distance, and spin of the golf ball.", "Increased club head moment of inertia increases the consistency of ball trajectory and direction for off-center hits.", "Many golf club heads are designed to optimize head center of gravity position and increase club head moment of inertia by using weighting ports or inserts.", "These designs may require complicated manufacturing and assembly processes and do not easily allow for optimization of head center of gravity position with precision.", "In addition, use of weighting ports can affect the overall aerodynamics of the club head.", "Therefore, there is a need in the art for the ability to distribute weight of golf club heads more precisely to optimize center of gravity positions and increase club head moment of inertia." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>FIG.", "1 illustrates a perspective view of a golf club head.", "FIG.", "2 illustrates a cross-sectional view of the golf club head of FIG.", "1 taken along line A-A.", "FIG.", "3 illustrates a cross-sectional view of one embodiment of a golf club head having a coating.", "FIG.", "4 illustrates a cross-sectional view of another embodiment of a golf club head having a coating.", "FIG.", "5 illustrates a cross-sectional view of another embodiment of a golf club head having a coating.", "FIG.", "6 illustrates a cross-sectional view of another embodiment of a golf club head having a coating.", "FIG.", "7 illustrates a cross-sectional view of another embodiment of a golf club head having a coating.", "FIG.", "8 illustrates a cross-sectional view of another embodiment of a golf club head having a coating.", "FIG.", "9 illustrates a cross-sectional view of another embodiment of a golf club head having a coating.", "FIG.", "10A illustrates a top view of another embodiment of a golf club head having a coating.", "FIG.", "10B illustrates a bottom view of the golf club head of FIG.", "10A FIG.", "11 illustrates a bottom view of another embodiment of a golf club head having a coating.", "FIG.", "12 illustrates a bottom view of another embodiment of a golf club head having a coating.", "FIG.", "13 illustrates a bottom view of another embodiment of a golf club head having a coating.", "FIG.", "14 illustrates a bottom view of another embodiment of a golf club head having a coating.", "FIG.", "15 illustrates a cross-sectional view of one embodiment of a golf club head having a first coating and a second coating.", "FIG.", "16 illustrates a cross-sectional view of another embodiment of a golf club head having a first coating and a second coating.", "FIG.", "17 illustrates a cross-sectional view of another embodiment of a golf club head having a first coating and a second coating.", "FIG.", "18 illustrates a cross sectional view of another embodiment of a golf club head having a first coating and a second coating.", "FIG.", "19 illustrates a cross-sectional view of another embodiment of a golf club head having a surface roughness, a first coating, and a second coating.", "FIG.", "20 illustrates a method of manufacturing a golf club head having a coating.", "FIG.", "21 illustrates a method of manufacturing a golf club head having a surface roughness and a coating.", "detailed-description description=\"Detailed Description\" end=\"lead\"?", "For illustrative purposes, the drawings described above may not represent actual scaling of the size of the coating or plurality of coatings relative to the club head size.", "For example, the coating thickness to club head thickness ratio may be shown as larger in the drawings than the actual coating thickness to club head thickness ratio per the dimensions disclosed within the detailed description.", "Other aspects of the disclosure will become apparent by consideration of the detailed description and accompanying drawings.", "For simplicity and clarity of illustration, the drawing figures illustrate the general manner of construction, and descriptions and details of well-known features and techniques may be omitted to avoid unnecessarily obscuring the present disclosure.", "Additionally, elements in the drawing figures are not necessarily drawn to scale.", "For example, the dimensions of some of the elements in the figures may be exaggerated relative to other elements to help improve understanding of embodiments of the present disclosure.", "The same reference numerals in different figures denote the same elements." ], [ "CROSS REFERENCES This claims benefit to U.S.", "Provisional Patent Application No.", "62/447,226, filed on Jan. 17, 2017, and is a continuation-in-part of U.S. patent application Ser.", "No.", "15/159,623, filed May 19, 2016, which claims benefit of U.S.", "Provisional Patent Application No.", "62/163,888, filed May 19, 2015, all of which are incorporated herein by reference.", "FIELD OF INVENTION The present disclosure relates to golf clubs having golf club heads with a high density thin outer layer.", "Specifically, the present disclosure relates to wood-type golf club heads, iron-type golf club heads, wedge-type golf club heads, and putter-type golf club heads.", "BACKGROUND Golf club heads may include wood-type club heads (e.g., drivers and fairway woods), iron-type club heads (e.g., irons and wedges), and putter-type club heads.", "Golf club head designs vary and generally aim to optimize head center of gravity position and increase club head moment of inertia.", "The head center of gravity position affects performance characteristics of the golf club including direction, trajectory, distance, and spin of the golf ball.", "Increased club head moment of inertia increases the consistency of ball trajectory and direction for off-center hits.", "Many golf club heads are designed to optimize head center of gravity position and increase club head moment of inertia by using weighting ports or inserts.", "These designs may require complicated manufacturing and assembly processes and do not easily allow for optimization of head center of gravity position with precision.", "In addition, use of weighting ports can affect the overall aerodynamics of the club head.", "Therefore, there is a need in the art for the ability to distribute weight of golf club heads more precisely to optimize center of gravity positions and increase club head moment of inertia.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates a perspective view of a golf club head.", "FIG.", "2 illustrates a cross-sectional view of the golf club head of FIG.", "1 taken along line A-A.", "FIG.", "3 illustrates a cross-sectional view of one embodiment of a golf club head having a coating.", "FIG.", "4 illustrates a cross-sectional view of another embodiment of a golf club head having a coating.", "FIG.", "5 illustrates a cross-sectional view of another embodiment of a golf club head having a coating.", "FIG.", "6 illustrates a cross-sectional view of another embodiment of a golf club head having a coating.", "FIG.", "7 illustrates a cross-sectional view of another embodiment of a golf club head having a coating.", "FIG.", "8 illustrates a cross-sectional view of another embodiment of a golf club head having a coating.", "FIG.", "9 illustrates a cross-sectional view of another embodiment of a golf club head having a coating.", "FIG.", "10A illustrates a top view of another embodiment of a golf club head having a coating.", "FIG.", "10B illustrates a bottom view of the golf club head of FIG.", "10A FIG.", "11 illustrates a bottom view of another embodiment of a golf club head having a coating.", "FIG.", "12 illustrates a bottom view of another embodiment of a golf club head having a coating.", "FIG.", "13 illustrates a bottom view of another embodiment of a golf club head having a coating.", "FIG.", "14 illustrates a bottom view of another embodiment of a golf club head having a coating.", "FIG.", "15 illustrates a cross-sectional view of one embodiment of a golf club head having a first coating and a second coating.", "FIG.", "16 illustrates a cross-sectional view of another embodiment of a golf club head having a first coating and a second coating.", "FIG.", "17 illustrates a cross-sectional view of another embodiment of a golf club head having a first coating and a second coating.", "FIG.", "18 illustrates a cross sectional view of another embodiment of a golf club head having a first coating and a second coating.", "FIG.", "19 illustrates a cross-sectional view of another embodiment of a golf club head having a surface roughness, a first coating, and a second coating.", "FIG.", "20 illustrates a method of manufacturing a golf club head having a coating.", "FIG.", "21 illustrates a method of manufacturing a golf club head having a surface roughness and a coating.", "For illustrative purposes, the drawings described above may not represent actual scaling of the size of the coating or plurality of coatings relative to the club head size.", "For example, the coating thickness to club head thickness ratio may be shown as larger in the drawings than the actual coating thickness to club head thickness ratio per the dimensions disclosed within the detailed description.", "Other aspects of the disclosure will become apparent by consideration of the detailed description and accompanying drawings.", "For simplicity and clarity of illustration, the drawing figures illustrate the general manner of construction, and descriptions and details of well-known features and techniques may be omitted to avoid unnecessarily obscuring the present disclosure.", "Additionally, elements in the drawing figures are not necessarily drawn to scale.", "For example, the dimensions of some of the elements in the figures may be exaggerated relative to other elements to help improve understanding of embodiments of the present disclosure.", "The same reference numerals in different figures denote the same elements.", "DETAILED DESCRIPTION In the embodiments described below, a high density thin outer layer of material or coating is applied to a golf club head.", "By distributing a high density thin outer layer of material over a portion or the entire golf club head, the weight distribution of the golf club head can be controlled.", "This strategic placement of high density coating materials on the golf club head maximize distribution of the weight to the outermost perimeter of the club away from the center of gravity thereby maximizing the ability to increase the moment of inertia.", "The coating of high density material may be at any thickness or depth, but is suitable for very thin layers between 0.10 inches to as thin as 0.00001 inches.", "The coating of high density material can be applied to a surface of the club head by vapor deposition, plasma spray, plating, or spotting.", "Therefore, greater precision can be achieved for particular weight placement on the golf club head at a desired depth or thickness using a variable set of metal alloy materials.", "Being able to control these variables using high density materials can be used to optimize the head center of gravity and maximize the club head moment of inertia to achieve desired performance characteristics of the club head.", "The terms “first,” “second,” “third,” “fourth,” and the like in the description and in the claims, if any, are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order.", "It is to be understood that the terms so used are interchangeable under appropriate circumstances such that the embodiments described herein are, for example, capable of operation in sequences other than those illustrated or otherwise described herein.", "Furthermore, the terms “include,” and “have,” and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, device, or apparatus that comprises a list of elements is not necessarily limited to those elements, but may include other elements not expressly listed or inherent to such process, method, system, article, device, or apparatus.", "The terms “left,” “right,” “front,” “back,” “top,” “bottom,” “over,” “under,” and the like in the description and in the claims, if any, are used for descriptive purposes and not necessarily for describing permanent relative positions.", "It is to be understood that the terms so used are interchangeable under appropriate circumstances such that the embodiments of the apparatus, methods, and/or articles of manufacture described herein are, for example, capable of operation in other orientations than those illustrated or otherwise described herein.", "Discretionary weight, as described herein, refers to a portion of the total weight of the club head that can be positioned to optimize performance without impacting the structural integrity of the club head.", "Before any embodiments of the disclosure are explained in detail, it is to be understood that the disclosure is not limited in its application to the details of construction and the arrangement of components set forth in the following description or illustrated in the following drawings.", "The disclosure is capable of other embodiments and of being practiced or of being carried out in various ways.", "FIGS.", "1-2 illustrate an embodiment of a golf club head 100 having a strike face 10 and a body 14 including a crown 18, a sole 24 opposite the crown 18, a heel 28, a toe 34 opposite the heel 28, and a back end 38.The body 14 and the strike face 10 together form the club head 100 having an outer surface 42 and an inner surface 46, as illustrated in the cross-sectional view of the club head 100 taken along line A-A in FIG.", "2.The body 14 of the club head 100 comprises a body material having a body material density.", "The body material may be any suitable material including titanium, stainless steel, tungsten, aluminum, other metals, composites, metal alloys, or any other material.", "In some embodiments, the body 14 of the club head 100 comprises different materials having different densities.", "For example, the crown 18 may comprise a crown material having a crown material density and the sole 24 may comprise a sole material having a sole material density, wherein the sole material and sole material density are different than the crown material and crown material density, respectively.", "In this example, the crown material density may be greater than the sole material density, or the crown material density may be less than the sole material density.", "In embodiments where the body 14 comprises different materials having different densities, the densities of each body material may be averaged to represent the body material density.", "The strike face 10 of the club head 100 comprises a strike face material having a strike face material density.", "The strike face material may be any suitable material including titanium, stainless steel, tungsten, aluminum, other metals, composites, metal alloys, or any other material.", "In other embodiments, the strike face 10 may comprise different materials having different densities.", "When the strike face 10 comprises different materials having different densities, the densities of each strike face material may be averaged to represent the strike face material density.", "The body material may be the same as the strike face material, or the body material may be different than the strike face material.", "Further, the body material density may be the same as the strike face material density, or the body material density may be different than the strike face material density.", "For example, the strike face material density may be higher than the body material density, or the strike face material density may be lower than the body material density.", "The club head 100 may further include a coating or plurality of coatings 50, as described in further detail in the embodiments of FIGS.", "3-18 below.", "In some embodiments, the club head 100 can include one coating 50 comprising a coating material having a coating material density (e.g.", "the embodiments of the club head illustrated FIGS.", "3-14 and described in further detail below).", "In some embodiments, the club head can include more than one coating.", "For example, in some embodiments the club head 100 can include a first coating 501 comprising a first coating material having a first coating density, and a second coating 502 comprising a second coating material having a second coating density (e.g.", "the embodiments of the club head illustrated FIGS.", "15-18 and described in further detail below).", "In many embodiments, the coating 50 has a surface area, a weight, and a thickness 56 defining a thickness profile.", "The surface area of the coating 50 defines a perimeter 62 (illustrated in FIGS.", "10-14) when specific portions of the club head 100 are covered by the coating 50.In embodiments where the coating 50 includes a plurality of coatings 50, the plurality of coatings can include a first coating 501 and a second coating 502, the first coating 501 having a first surface area, a first weight, and a first thickness 561 defining a first thickness profile, and the second coating 502 having a second surface area, a second weight, a second thickness 562 defining a second thickness profile.", "The coating or plurality of coatings 50 can be applied to the club head 100 in various positions or plurality of positions, as described further in the embodiments of FIGS.", "3-14 below.", "In some embodiments, the coating 50 can be applied directly onto one or both of the outer surface of the club head body 14 and the strike face 10 of the club head 100.In some embodiments, one or more of the coatings of the plurality of coatings 50 can be applied directly onto another one of the coatings of the plurality of coatings 50.FIG.", "3 illustrates an embodiment of the club head 200 having a strike face 10 and a body 14 including a crown 18, a sole 24 opposite the crown 18, a heel 28, a toe 34 opposite the heel 28, and a back end 38.The body 14 and the strike face 10 together form the club head 200 having an outer surface 42 and an inner surface 46.The club head 200 further includes a coating 50.Referring to FIG.", "3, in the illustrated embodiment, the coating 50 is positioned on the outer surface 42 of the club head 200.Further, the coating 50 covers or is positioned over the entire outer surface 42 of the club head 200 including the strike face 10 and the body 14.Accordingly, in the illustrated embodiment, the strike face 10, the crown 18, the sole 24, the heel 28, the toe 34, and the back end 38 of the club head 200 are covered by the coating 50.In the illustrated embodiment, the thickness 56 of the coating 50 is approximately constant.", "For example, the thickness 56 of the coating 50 on the crown 18 is approximately the same as the thickness on the sole 24, the heel 28, the toe 34, the back end 38, and the strike face 10.FIG.", "4 illustrates another embodiment of the club head 300 having a strike face 10 and a body 14 including a crown 18, a sole 24 opposite the crown 18, a heel 28, a toe 34 opposite the heel 28, and a back end 38.The body 14 and the strike face 10 together form the club head 300 having an outer surface 42 and an inner surface 46.The club head 300 further includes a coating 50.Referring to FIG.", "4, in the illustrated embodiment, the coating 50 is positioned on the outer surface 42 of the club head 200.Further, in the illustrated embodiment, the coating 50 covers or is positioned over a portion of the outer surface 42 of the club head 300.Specifically, the coating 50 covers or is positioned over the body 14 of the club head 300 including the crown 18, the sole 24, the heel 28, the toe 34, and the back end 38.Accordingly, the crown 18, the sole 24, the heel 28, the toe 34, and the back end 38 are covered by the coating 50.The strike face 10 is not covered by the coating 50.Further referring to FIG.", "4, in the illustrated embodiment, the thickness 56 of the coating 50 is approximately constant.", "For example, the thickness 56 of the coating 50 on the crown 18 is approximately the same as the thickness on the sole 24, the heel 28, the toe 34, and the back end 38.Further, the thickness 56 of the coating 50 tapers or decreases near the edges of the coating 50 (e.g.", "near the periphery of the strike face 10).", "For example, in the illustrated embodiment, the thickness of the coating 50 tapers or decreases near the strike face 10 of the club head 200.FIG.", "5 illustrates another embodiment of the club head 400 having a strike face 10 and a body 14 including a crown 18, a sole 24 opposite the crown 18, a heel 28, a toe 34 opposite the heel 28, and a back end 38.The body 14 and the strike face 10 together form the club head 400 having an outer surface 42 and an inner surface 46.The club head 400 further includes a coating 50.In the illustrated embodiment, the coating 50 is positioned on the outer surface 42 of the club head 400.Further, in the illustrated embodiment, the coating 50 covers or is positioned over a portion of the outer surface 42 of the club head 400.Specifically, the coating 50 covers or is positioned over the strike face 10 of the club head 400.Further, in the illustrated embodiment, the thickness 56 of the coating 50 is approximately constant.", "For example, the thickness 56 of the coating 50 on the strike face 10 near the heel 28, the toe 34, the crown 18, or the sole 24 is approximately the same.", "Further, the thickness 56 of the coating 50 tapers or decreases near the edges of the coating 50.For example, the thickness of the coating 50 tapers or decreases near the periphery of the strike face 10.FIG.", "6 illustrates another embodiment of the club head 500 having a strike face 10 and a body 14 including a crown 18, a sole 24 opposite the crown 18, a heel 28, a toe 34 opposite the heel 28, and a back end 38.The body 14 and the strike face 10 together form the club head 500 having an outer surface 42 and an inner surface 46.The club head 500 further includes a coating 50.Referring to FIG.", "6, in the illustrated embodiment, the coating 50 is positioned on the outer surface 42 of the club head 500.Further, in the illustrated embodiment, the coating 50 covers or is positioned over a portion of the outer surface 42 of the club head 500.Specifically, the coating 50 covers or is positioned over at least a portion of the back end 38 of the club head 500.In some embodiments, the coating 50 can extend along the entire back end 38 from the heel 28 to the toe 34 of the club head 500.Further, in some embodiments, the coating 50 can extend along a portion of the back end 38 of the club head 500.For example, in some embodiments, the coating 50 can extend along the back end 38 from near the heel 28 to near the toe 34 of the club head 500.Further referring to FIG.", "6, in the illustrated embodiment, the thickness 56 of the coating 50 is greatest near the rearward most part of the back end 38 and gradually tapers or decreases near the edges of the coating 50 toward the crown 18 and the sole 24.For example, the thickness of the coating 50 tapers or decreases near the crown 18 and the sole 24 of the club head 500.FIG.", "7 illustrates another embodiment of the club head 600 having a strike face 10 and a body 14 including a crown 18, a sole 24 opposite the crown 18, a heel 28, a toe 34 opposite the heel 28, and a back end 38.The body 14 and the strike face 10 together form the club head 600 having an outer surface 42 and an inner surface 46.The club head 600 further includes a coating 50.Referring to FIG.", "7, in the illustrated embodiment, the coating 50 is positioned on the outer surface 42 of the club head 600.Further, in the illustrated embodiment, the coating 50 covers or is positioned over a portion of the outer surface 42 of the club head 600.Specifically, the coating 50 covers or is positioned over a portion of the sole 24 near the back end 38 of the club head 600.In some embodiments, the coating 50 can extend along the entire length of the sole 24 from near the heel 28 to near the toe 34 of the club head 600.Further, in some embodiments, the coating 50 can extend along only a portion of the sole 24.In the illustrated embodiment, the thickness 56 of the coating 50 gradually tapers or decreases near the edges of the coating 50 toward the back end 38 and the strike face 10.FIG.", "8 illustrates another embodiment of the club head 700 having a strike face 10 and a body 14 including a crown 18, a sole 24 opposite the crown 18, a heel 28, a toe 34 opposite the heel 28, and a back end 38.The body 14 and the strike face 10 together form the club head 700 having an outer surface 42 and an inner surface 46.The club head 700 further includes a coating 50 having more than one discrete portion.", "Referring to FIG.", "8, in the illustrated embodiment, the coating 50 is positioned on the outer surface 42 of the club head 700.Further, in the illustrated embodiment, the coating 50 covers or is positioned over a portion of the outer surface 42 of the club head 700.Specifically, the coating 50 includes a first portion that covers or is positioned over a portion of the sole 24 near the back end 38 of the club head 600, and a second portion that covers or is positioned over a portion of the crown 18 near the back end 38 of the club head.", "In some embodiments, the first portion of the coating 50 can extend along the entire length of the sole 24 from near the heel 28 to near the toe 34 of the club head 700.Further, in some embodiments, the second portion of the coating 50 can extend along only a portion of the crown 18 from near the heel 28 to near the toe 34 of the club head 700.In the illustrated embodiment, the thickness 56 of the coating 50 gradually tapers or decreases near the edges of the first portion of the coating 50 on the sole 24 and near the edges of the second portion of the coating 50 on the crown 18.FIG.", "9 illustrates another embodiment of club head 800 having a strike face 10 and a body 14 including a crown 18, a sole 24 opposite the crown 18, a heel 28, a toe 34 opposite the heel 28, and a back end 38.The body 14 and the strike face 10 together form the club head 800 having an outer surface 42 and an inner surface 46.The club head 800 further includes a coating 50.Referring to FIG.", "9, in the illustrated embodiment, the coating 50 is positioned on the outer surface 42 of the club head 800.Further, in the illustrated embodiment, the coating 50 covers or is positioned over a portion of the outer surface 42 of the club head 800.Specifically, the coating 50 covers or is positioned over at least a portion of the back end 38 of the club head 800.In some embodiments, the coating 50 can extend along the entire back end 38 from the heel 28 to the toe 34 of the club head 800.Further, in some embodiments, the coating 50 can extend along a portion of the back end 38 of the club head 800.For example, in some embodiments, the coating 50 can extend along the back end 38 from near the heel 28 to near the toe 34 of the club head 800.Further referring to FIG.", "9, in the illustrated embodiment, the thickness 56 of the coating 50 varies defining a thickness profile.", "The thickness profile illustrated can be a bowtie contour of the coating 50 at the back end 38 of the club head 800.In the illustrated embodiment, the thickness 56 of the coating 50 gradually increases and then decreases in a direction from the back end 38 toward the crown 18 of the club head 800.Further, in the illustrated embodiment, the thickness 56 of the coating 50 gradually increases and then decreases in a direction from the back end 38 toward the sole 24 of the club head 800.FIGS.", "10A and 10B illustrate another embodiment of the club head 900 having a strike face 10 and a body 14 including a crown 18, a sole 24 opposite the crown 18, a heel 28, a toe 34 opposite the heel 28, and a back end 38.The body 14 and the strike face 10 together form the club head 900 having an outer surface 42 and an inner surface 46.The club head 900 further includes a coating 50 having more than one discrete portion.", "Referring to FIGS.", "10A and 10B, in the illustrated embodiment, the coating 50 is positioned on the outer surface 42 of the club head 900.Further, in the illustrated embodiment, the coating 50 covers or is positioned over a portion of the outer surface 42 of the club head 700.Specifically, in the illustrated embodiment, the coating 50 includes a first portion that covers or is positioned over the entire crown 18 (FIG.", "10A) and a second portion that covers or is positioned over the entire sole 24 (FIG.", "10B) of the club head 900.In the illustrated embodiment, the thickness 56 of the first portion of the coating 50 positioned on the crown 18 is approximately constant.", "Further, in the illustrated embodiment, the thickness 56 of the second portion of the coating 50 positioned on the sole 24 is approximately constant.", "FIG.", "11 illustrates another embodiment of the club head 1100 having a strike face 10 and a body 14 including a crown 18, a sole 24 opposite the crown 18, a heel 28, a toe 34 opposite the heel 28, and a back end 38.The body 14 and the strike face 10 together form the club head 1100 having an outer surface 42 and an inner surface 46.The club head 1100 further includes a coating 50.Referring to FIG.", "11, in the illustrated embodiment, the coating 50 is positioned on the outer surface 42 of the club head 1100.Further, in the illustrated embodiment, the coating 50 covers or is positioned over a portion of the outer surface 42 of the club head 600.Specifically, the coating 50 covers or is positioned over a portion of the sole 24 near the center region of the back end 38 of the club head 600.In some embodiments, the coating 50 covers a portion of the club head 600 having a weight pad or weight member.", "In some embodiments, the coating 50 directly contacts the outer surface 42 of the club head 1100.In the illustrated embodiment, the perimeter 62 of the coating 50 defines a trapezoidal shape, corresponding to the shape of the weight pad or weight member.", "The shape of the coating 50 can correspond to any weight pad or weight member that can be any shape such as a trapezoidal, square, hexagonal, circular, triangular, or any other polygon or shape with at least one curved surface.", "Further, in the illustrated embodiment, the thickness 56 of the coating 50 is approximately constant.", "FIG.", "12 illustrates another embodiment of the club head 1200 having a strike face 10 and a body 14 including a crown 18, a sole 24 opposite the crown 18, a heel 28, a toe 34 opposite the heel 28, and a back end 38.The body 14 and the strike face 10 together form the club head 1200 having an outer surface 42 and an inner surface 46.The club head 1200 further includes a coating 50 having more than one discrete portion.", "Referring to FIG.", "12, in the illustrated embodiment, the coating 50 is positioned on the outer surface 42 of the club head 1200.Further, in the illustrated embodiment, the coating 50 covers or is positioned over a portion of the outer surface 42 of the club head 1200.Specifically, the coating 50 includes a first portion that covers or is positioned over a portion of the sole 24 near the toe 34 (between the toe 34 and the rear end 38) and a second portion that covers or is positioned over a portion of the sole 24 near the heel 28 (between the heel 28 and the rear end 38) of the club head 1200.In some embodiments, the first portion is spaced equally between the rear end 38 and the toe 34.In some embodiments, the second portion is spaced equally between the rear end 38 and the heel 28.In the illustrated embodiment, the perimeter 62 of the first portion of the coating 50 defines a rectangular shape, and the perimeter 62 of the second portion of the coating 50 defines a rectangular shape.", "In some embodiments, a section of the perimeter 62 of the first portion abuts a weight pad or weight member of the golf club head 1200.In some embodiments, a section of the perimeter 62 of the second portion abuts a weight pad or weight member of the golf club head 1200.Further, in the illustrated embodiment, the thickness 56 of the coating 50 is approximately constant.", "FIG.", "13 illustrates another embodiment of the club head 1300 having a strike face 10 and a body 14 including a crown 18, a sole 24 opposite the crown 18, a heel 28, a toe 34 opposite the heel 28, and a back end 38.The body 14 and the strike face 10 together form the club head 1300 having an outer surface 42 and an inner surface 46.The club head 1300 further includes a coating 50.Referring to FIG.", "13, in the illustrated embodiment, the coating 50 is positioned on the outer surface 42 of the club head 1300.Further, in the illustrated embodiment, the coating 50 covers or is positioned over a portion of the outer surface 42 of the club head 1300.Specifically, the coating 50 is positioned over a portion of the sole 24 near the heel 28 of the club head 1200.In some embodiments, the coating 50 is spaced equally between the rear end 38 and the heel 28.In the illustrated embodiment, the perimeter 62 of the coating 50 defines a rectangular shape.", "In some embodiments, a section of the perimeter 62 of the coating 50 abuts a weight pad or weight member of the golf club head 1200.Further, in the illustrated embodiment, the thickness 56 of the coating 50 is approximately constant.", "FIG.", "14 illustrates another embodiment of the club head 1400 having a strike face 10 and a body 14 including a crown 18, a sole 24 opposite the crown 18, a heel 28, a toe 34 opposite the heel 28, and a back end 38.The body 14 and the strike face 10 together form the club head 1400 having an outer surface 42 and an inner surface 46.The club head 1400 further includes a coating 50.Referring to FIG.", "14, in the illustrated embodiment, the coating 50 is positioned on the outer surface 42 of the club head 1400.Further, in the illustrated embodiment, the coating 50 covers or is positioned over a portion of the outer surface 42 of the club head 1400.Specifically, the coating 50 is positioned over the entire sole 24 of the club head 1400.In the illustrated embodiment, the thickness 56 of the coating 50 is approximately constant.", "FIG.", "15 illustrates an embodiment of the club head 2000 having a strike face 10 and a body 14 including a crown 18, a sole 24 opposite the crown 18, a heel 28, a toe 34 opposite the heel 28, and a back end 38.The body 14 and the strike face 10 together form the club head 2000 having an outer surface 42 and an inner surface 46.The club head 2000 further includes a first coating 501 and second coating 502.Referring to FIG.", "15, in the illustrated embodiment, the first coating 501 is positioned on the outer surface 42 of the club head 2000.Further, the first coating 501 covers or is positioned over the entire outer surface 42 of the club head 2000 including the strike face 10 and the body 14.Accordingly, in the illustrated embodiment, the strike face 10, the crown 18, the sole 24, the heel 28, the toe 34, and the back end 38 of the club head 2000 are covered by the first coating 501.In the illustrated embodiment, the thickness 561 of the first coating 501 is approximately constant.", "For example, the thickness 561 of the first coating 501 on the crown 18 is approximately the same as the thickness 561 on the sole 24, the heel 28, the toe 34, the back end 38, and the strike face 10.Further referring to FIG.", "15, in the illustrated embodiment, the second coating 502 covers or is positioned over the first coating 501 of the club head 2000.In the illustrated embodiment, the thickness 562 of the second coating 502 is approximately constant.", "For example, the thickness 562 of the second coating 502 on the crown 18 is approximately the same as the thickness 562 on the sole 24, the heel 28, the toe 34, the back end 38, and the strike face 10.FIG.", "16 illustrates another embodiment of the club head 2100 having a strike face 10 and a body 14 including a crown 18, a sole 24 opposite the crown 18, a heel 28, a toe 34 opposite the heel 28, and a back end 38.The body 14 and the strike face 10 together form the club head 2100 having an outer surface 42 and an inner surface 46.The club head 2100 further includes a first coating 501 and second coating 502.Referring to FIG.", "16, in the illustrated embodiment, the first coating 501 is positioned on the outer surface 42 of the club head 2100.Further, in the illustrated embodiment, the first coating 501 covers or is positioned over a portion of the outer surface 42 of the club head 2100.Specifically, the first coating 501 covers or is positioned over a portion of the crown 18 near the back end 38 of the club head 2100.In some embodiments, the first coating 501 can extend along the entire length of the crown 18 from near the heel 28 to near the toe 34 of the club head 2100.In the illustrated embodiment, the thickness 561 of the first coating 501 gradually tapers or decreases near the edges of the first coating 501 on the crown 18.Further referring to FIG.", "16, in the illustrated embodiment, the second coating 502 is positioned on the outer surface 42 of the club head 2100.Further, in the illustrated embodiment, the second coating 502 covers or is positioned over a portion of the outer surface 42 of the club head 2100.Specifically, the second coating 502 covers or is positioned over a portion of the sole 24 near the back end 38 of the club head 2100.In some embodiments, the second coating 502 can extend along the entire length of the sole 24 from near the heel 28 to near the toe 34 of the club head 2100.In the illustrated embodiment, the thickness 562 of the second coating 502 gradually tapers or decreases near the edges of the second coating 502 on the sole 24.FIG.", "17 illustrates another embodiment of the club head 2200 having a strike face 10 and a body 14 including a crown 18, a sole 24 opposite the crown 18, a heel 28, a toe 34 opposite the heel 28, and a back end 38.The body 14 and the strike face 10 together form the club head 2200 having an outer surface 42 and an inner surface 46.The club head 2200 further includes a first coating 501 and second coating 502.Referring to FIG.", "17, in the illustrated embodiment, the first coating 501 is positioned on the outer surface 42 of the club head 2200.Further, the first coating 501 covers or is positioned over the entire body 14 of the club head 2200.Accordingly, the crown 18, the sole 24, the heel 28, the toe 34, and the back end 38 of the club head 2200 are covered by the first coating 501.In the illustrated embodiment, the thickness 561 of the first coating 501 is approximately constant.", "For example, the thickness 561 of the first coating 501 on the crown 18 is approximately the same as the thickness 561 on the sole 24, the heel 28, the toe 34, the back end 38, and the strike face 10.Further referring to FIG.", "17, in the illustrated embodiment, the second coating 502 covers or is positioned over a portion of the first coating 501 of the club head 2200 near the back end 38.In some embodiments, the second coating 502 can extend along the entire back end 38 from the heel 28 to the toe 34 of the club head 2200.Further, in some embodiments, the second coating 502 can extend along a portion of the back end 38 of the club head 2200.For example, in some embodiments, the second coating 502 can extend along the back end 38 from near the heel 28 to near the toe 34 of the club head 2200.In the illustrated embodiment, the thickness 562 of the second coating 502 is greatest near the rearward most part of the back end 38 and gradually tapers or decreases near the edges of the second coating 502.For example, the thickness of the second coating 502 tapers or decreases near the crown 18 and the sole 24 of the club head 2200.FIG.", "18 illustrates another embodiment of the club head 2300 having a strike face 10 and a body 14 including a crown 18, a sole 24 opposite the crown 18, a heel 28, a toe 34 opposite the heel 28, and a back end 38.The body 14 and the strike face 10 together form the club head 2300 having an outer surface 42 and an inner surface 46.The club head 2300 further includes a first coating 501 and second coating 502.Referring to FIG.", "18, in the illustrated embodiment, the first coating 501 is positioned on the outer surface 42 of the club head 2300.Further, the first coating 501 covers or is positioned over a portion of the club head 2300 including the back end 38.In the illustrated embodiment, the thickness 561 of the first coating 501 is greatest near the rearward most part of the back end 38 and gradually tapers or decreases near the edges of the first coating 501.For example, the thickness of the first coating 501 tapers or decreases near the crown 18 and the sole 24 of the club head 2300.Further referring to FIG.", "18, in the illustrated embodiment, the second coating 502 covers or is positioned over a portion of the first coating 501 and the outer surface 42 of the club head 2300.In the illustrated embodiment, the thickness 562 of the second coating 502 is approximately constant and tapers toward the edges of the second coating 502.Further referring to FIG.", "18, in some embodiments, the first and second coatings 501, 502 can extend along the entire back end 38 from the heel 28 to the toe 34 of the club head 2300.Further, in some embodiments, the first and second coatings 501, 502 can extend along a portion of the back end 38 of the club head 2300.For example, in some embodiments, the first and second coatings 501, 502 can extend along the back end 38 from near the heel 28 to near the toe 34 of the club head 2200.As described above, FIGS.", "3-18 illustrate various embodiments of the club head having a coating or plurality of coatings 50 (e.g.", "club head 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, or 2300).", "The embodiments of the club head having the coating or plurality of coatings 50 described herein are not limited by position.", "In other embodiments, the coating 50 can be positioned anywhere on the club head.", "For example, the coating 50 can cover at least a portion of the crown 18, the sole 24, the heel 28, the toe 34, the back end 38, the strike face 10, or any combination thereof on the outer surface 42 of the club head.", "For further example, the coating 50 can cover at least a portion of the crown 18, the sole 24, the heel 28, the toe 34, the back end 38, the strike face 10, or any combination thereof on the inner surface 46 of the club head.", "Further, the embodiments of the club head having one or more coatings 50 (e.g.", "club head 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, or 2300) described herein are not limited by number of discrete coating portions.", "For example, in other embodiments, each of the plurality of coatings 50 can have any number of discrete portions such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or any other number of discrete portions.", "Further, the embodiments of the club head having the coating or plurality of coatings 50 (e.g.", "club head 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, or 2300) described herein are not limited by number of coatings.", "For example, in other embodiments, the one or more coatings 50 can include 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or any other number of coatings.", "As described above, FIGS.", "15-18 illustrate various embodiments of the club head 2000, 2100, 2200, 2300 having a plurality of coatings 50 including a first coating 501 and a second coating 502 positioned in various locations.", "In other embodiments, the first coating 501 and the second coating 502 can be positioned anywhere on the club head.", "For example, the first coating 501 can cover at least a portion of the crown 18, the sole 24, the heel 28, the toe 34, the back end 38, the strike face 10, the hosel 40, or any combination thereof on the outer surface 42 of the club head.", "For further example, the first coating 501 can cover at least a portion of the crown 18, the sole 24, the heel 28, the toe 34, the back end 38, the strike face 10, the hosel 40, or any combination thereof on the inner surface 46 of the club head.", "In addition, the second coating 502 can cover at least a portion of the crown 18, the sole 24, the heel 28, the toe 34, the back end 38, the strike face 10, the hosel 40, or any combination thereof on the outer surface 42 of the club head.", "Further, the second coating 502 can cover at least a portion of the crown 18, the sole 24, the heel 28, the toe 34, the back end 38, the strike face 10, the hosel 40, or any combination thereof on the inner surface 46 of the club head.", "The second coating 502 may be applied to the club head 200 in the same position as the first coating 501, or the second coating 502 may be applied to the club head 200 in a different position than the first coating 501.Further, the second coating 502 may be applied to at least a portion of the same position as the first coating 501.Referring to FIGS.", "3-14, the embodiments of the club head having one or more coatings 50 (e.g.", "club head 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, or 2300) described herein are not limited by coating shape.", "For example, in other embodiments, the perimeter 62 of the coating 50 can define any shape such as a circle, ellipse, triangle, square, rectangle, or any other polygon or shape with at least one curved surface.", "As described above, FIGS.", "15-18 illustrate various embodiments of the club head 2000, 2100, 2200, 2300 having a plurality of coatings 50 including a first coating 501 and a second coating 502 having various shapes.", "In some embodiments, the first coating 501 and the second coating 502 have similar shapes.", "In other embodiments, the first coating 501 and the second coating 502 can have different shapes.", "For example, the perimeter 62 of the first coating 501 can define any shape such as a circle, ellipse, triangle, square, rectangle, or any other polygon or shape with at least one curved surface.", "For further example, the perimeter 62 of the second coating 502 can define any shape such as a circle, ellipse, triangle, square, rectangle, or any other polygon or shape with at least one curved surface.", "Referring to FIGS.", "3-14, the embodiments of the club head having one or more coatings 50 (e.g.", "club head 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, or 2300) described herein are not limited by thickness profile.", "In other embodiments, the coating can have any thickness profile, such as constant, linear, quadratic, sinusoidal, exponential, or any other suitable profile.", "For example, thickness 56 of the coating 50 may increase when moving away from the perimeter 62 or the thickness 56 of the coating 50 may decrease when moving away from the perimeter 62.Further, the thickness 56 of the coating 50 may be greatest at any position or plurality of positions on the club head (e.g.", "club head 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, or 2300), such as, for example, the crown 18, the sole 24, the heel 28, the toe 34, the back end 38, the strike face 10, the hosel 40, or any combination of the described positions.", "In embodiments of the club head 2000, 2100, 2200, 2300 having a plurality of coatings 50 including a first coating 501 and a second coating 502, the first thickness 561 of the first coating 501 can have the same thickness profile as the second thickness 562 of the second coating 502, or the first thickness 561 of the first coating 501 can have a different thickness profile than the second thickness 562 of the second coating 502.In many embodiments (e.g.", "club head 100, 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, 2300), the surface area of the coating 50 may range from approximately 0-70 square inches (in2).", "For example, the surface area of the coating 50 may be approximately 0, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, or 70 in2.The surface area of the coating may cover any percentage (i.e.", "0%-100%) of the club head surface area.", "For example, the surface area may cover approximately 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, or 100% of the surface area of the club head 100.As described above, the surface area of the coating 50 can comprise a single, discrete portion, such as, for example when the coating 50 covers the entire club head (e.g.", "club head 200) or when the coating 50 covers at least a portion of the crown 18, the sole 24, the heel 28, the toe 34, the back end 38, or the strike face 10 (e.g.", "club head 300, 400, 500, 600, 800, 1100, 1300, 1400).", "Conversely, the surface area of the coating 50 can comprise a plurality of discrete portions when the coating 50 includes more than one portion (e.g.", "club head 700, 900, 1200).", "For example, the surface area of the coating 50 comprises a plurality of discrete portions when the coating 50 includes a first portion that covers at least a portion of the crown 18 and a second portion that covers at least a portion of the sole 24 (e.g.", "club head 900).", "When the coating 50 is divided into a plurality of portions, the sum of the surface areas of each portion define the surface area of the coating 50.In these or other embodiments, the surface area of the coating 50 may range from approximately 0-70 in2.For example, the surface area of the coating 50 may be approximately 0, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, or 70 in2.Further, the surface area of the coating 50 may cover any percentage (i.e.", "0%-100%) of the club head surface area.", "For example, the surface area of the coating 50 may cover approximately 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, or 100% of the surface area of the club head.", "As described above, FIGS.", "15-18 illustrate various embodiments of a club head 2000, 2100, 2200, 2300 having a plurality of coatings 50 including a first coating 501 and a second coating 502 positioned in various locations.", "In these or other embodiments, the first surface area of the first coating 501 may range from approximately 0-70 square inches (in2).", "For example, the first surface area of the first coating 501 may be approximately 0, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, or 70 in2.Further, the first surface area of the first coating 501 may cover any percentage (i.e.", "0%-100%) of the club head surface area.", "For example, the first surface area of the first coating 501 may cover approximately 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, or 100% of the surface area of the club head.", "Further, in these or other embodiments, the second surface area of the second coating 502 may range from approximately 0-70 square inches (in2).", "For example, the second surface area of the second coating 502 may be approximately 0, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, or 70 in2.For example, the second surface area of the second coating 502 may be approximately 0, 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, or 70 in2.Further, the second surface area of the second coating 502 may cover any percentage (i.e.", "0%-100%) of the club head surface area.", "For example, the second surface area of the second coating 502 may cover approximately 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, or 100% of the surface area of the club head.", "Further still, in these or other embodiments, the first surface area of the first coating 501 can be the same as the second surface area of the second coating 502, or the first surface area of the first coating 501 can be different than the second surface area of the second coating 502.Referring to Table 1 below, the coating material can be any material capable of being applied to the club head (e.g.", "club head 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, or 2300) in a thin layer between 0.10 inches and 0.00001 inches in thickness or depth 56.The coating material can be a particular metal alloy having a coating material density.", "The density of the coating material can be between 100 g/in3 to 400 g/in3.For example, the coating material density may be 100, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 260, 270, 280, 290, 300, 310, 320, 330, 340, 350, 360, 370, 380, 390, or 400 g/in3.In many embodiments, the coating material density is greater than at least one of the body material density or the strike face material density.", "For example, in some embodiments, the coating material density is greater than the body material density.", "For further example, in some embodiments, the coating material density is greater than the strike face material density.", "For further example, in some embodiments, the coating material density is greater than both the body material density and the strike face material density.", "The density of the coating material applied to the body 14 of the club head (e.g.", "club head 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, or 2300) can be 1.0 times, 1.25 times, 1.50 times, 2.0 times, 2.25 times, 2.50 times, 2.75 times, 3.0 times or higher than the body material density.", "The density of the coating material applied to the strike face 10 of the club head (e.g.", "club head 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, or 2300) can be 1.0 times, 1.25 times, 1.50 times, 2.0 times, 2.25 times, 2.50 times, 2.75 times, 3.0 times or higher than the strike face material density.", "Further referring to Table 1, the coating material may be beryllium based alloy, a copper based alloy, a palladium based alloy, a tungsten based alloy, a rhenium based alloy, a cobalt based alloy, a rhodium based alloy, a ruthenium based alloy, a molybdenum based alloy, a nickel based alloy, an iron based alloy, or cadium based alloy.", "The coating material may be a pure-based metal such as pure beryllium, pure copper, pure palladium, pure tungsten, pure rhenium, pure cobalt, pure rhodium, pure ruthenium, pure molybdenum, pure nickel, pure iron, or pure cadium.", "Table 1 illustrates exemplary coating materials and their densities.", "The coating material may be any alloy including, but not limited to, cobalt, beryllium, copper alloy, a tungsten carbide alloy, or a tungsten, rhenium alloy.", "TABLE 1 Exemplary coating materials and associated coating material densities Coating Material Exemplary Coating Materials Density (g/in3) Cobalt Beryllium Copper 144.70 Pure Palladium 199.27 Tungsten Carbide 256.13 Tungsten Rhenium 314.96 Pure Tungsten 316.27 The thickness 56 of the coating 50 applied to the body 14 of the club head (e.g.", "club head 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, or 2300) can range from approximately 0.00001-0.10 inches to add approximately 1-25 grams, 1-20 grams, 1-15 grams, or 1-10 grams of discretionary weight to the club head 100.The thickness 56 of the coating 50 can be approximately 0.00001 inches (0.254 μm), 0.000025 inches (0.635 μm), 0.00005 inches (1.27 μm), 0.000075 inches (1.905 μm), 0.0001 inches (2.54 μm), 0.00025 inches (6.35 μm), 0.0005 inches (12.7 μm), 0.00075 inches (19.05 μm), 0.001 inches (25.4 μm), 0.0025 inches (63.5 μm), 0.005 inches (127 μm), 0.0075 inches (190.5 μm), 0.01 inches (254 μm), 0.025 inches (635 μm), 0.05 inches (1270 μm), 0.075 inches (1905 μm), or 0.10 inches (2540 μm).", "The thickness 56 of the coating 50 can range from approximately 0.00001 inches (0.254 μm) to 0.0075 inches (190.5 μm), 000025 inches (0.635 μm) to 0.075 inches (1905 μm), 0.00075 inches (1.905 μm) to 0.05 inches (1270 μm), 0.001 inches (25.4 μm) to 0.025 inches (635 μm), 0.0025 inches (63.5 μm) to 0.01 inches (254 μm), or 0.005 inches (127 μm) to 0.0075 inches (190.5 μm).", "The thickness 56 of the coating 50 may add approximately 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25 grams of discretionary weight to the club head 100.In embodiments of the club head 2000, 2100, 2200, 2300 having a plurality of coatings 50 including a first coating 501 and a second coating 502.The first coating 501 can have the same or a different thickness than the second coating 502.The first thickness 561 of the first coating 501 may range from approximately 0.00001-0.10 inches to add approximately 1-25 grams, 1-20 grams, 1-15 grams, or 1-10 grams of discretionary weight to the club head 200.For example, the first thickness 561 of the first coating 501 can be approximately 0.00001 inches (0.254 μm), 0.000025 inches (0.635 μm), 0.00005 inches (1.27 μm), 0.000075 inches (1.905 μm), 0.0001 inches (2.54 μm), 0.00025 inches (6.35 μm), 0.0005 inches (12.7 μm), 0.00075 inches (19.05 μm), 0.001 inches (25.4 μm), 0.0025 inches (63.5 μm), 0.005 inches (127 μm), 0.0075 inches (190.5 μm), 0.01 inches (254 μm), 0.025 inches (635 μm), 0.05 inches (1270 μm), 0.075 inches (1905 μm), or 0.10 inches (2540 μm).", "The thickness 56 of the first coating 501 can range from approximately 0.00001 inches (0.254 μm) to 0.0075 inches (190.5 μm), 000025 inches (0.635 μm) to 0.075 inches (1905 μm), 0.00075 inches (1.905 μm) to 0.05 inches (1270 μm), 0.001 inches (25.4 μm) to 0.025 inches (635 μm), 0.0025 inches (63.5 μm) to 0.01 inches (254 μm), or 0.005 inches (127 μm) to 0.0075 inches (190.5 μm).", "For further example, the first coating 501 may add approximately 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25 grams of discretionary weight to the club head.", "Further, the second thickness 562 of the second coating 502 may range from approximately 0.00001-0.10 inches to add approximately 1-25 grams, 1-20 grams, 1-15 grams, or 1-10 grams of discretionary weight to the club head 200.For example, the second thickness 562 of the second coating 502 may be approximately 0.00001 inches (0.254 μm), 0.000025 inches (0.635 μm), 0.00005 inches (1.27 μm), 0.000075 inches (1.905 μm), 0.0001 inches (2.54 μm), 0.00025 inches (6.35 μm), 0.0005 inches (12.7 μm), 0.00075 inches (19.05 μm), 0.001 inches (25.4 μm), 0.0025 inches (63.5 μm), 0.005 inches (127 μm), 0.0075 inches (190.5 μm), 0.01 inches (254 μm), 0.025 inches (635 μm), 0.05 inches (1270 μm), 0.075 inches (1905 μm), or 0.10 inches (2540 μm).", "The thickness 56 of the second coating 502 can range from approximately 0.00001 inches (0.254 μm) to 0.0075 inches (190.5 μm), 000025 inches (0.635 μm) to 0.075 inches (1905 μ), 0.00075 inches (1.905 μm) to 0.05 inches (1270 μm), 0.001 inches (25.4 μm) to 0.025 inches (635 μm), 0.0025 inches (63.5 μm) to 0.01 inches (254 μm), or 0.005 inches (127 μm) to 0.0075 inches (190.5 μm).", "For further example, the second coating 502 may add approximately 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25 grams of discretionary weight to the club head.", "Additional layers including a third coating 503, fourth coating 504, or fifth coating 505 can have similar thicknesses and relationships to the other coating layers as the first 501 and second coating 502.In these or other embodiments, the first coating 501 and the second coating 502 may be applied to the club head (e.g.", "club head 2000, 2100, 2200, 2300) such that the first weight of first coating 501 and the second weight of the second coating 502 together add a desired discretionary weight of the club head.", "The total weight of the coating or plurality of coatings 50 (e.g.", "sum of the first weight and the second weight) can range from approximately 1-25 grams, 1-20 grams, 1-15 grams, or 1-10 grams.", "For example, the sum of the first weight and the second weight can be approximately 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25 grams.", "In many embodiments, the coating or plurality of coatings 50, as described herein, may be used to position discretionary weight to achieve specific head center of gravity positions.", "For example, the coating 50 may be applied to the club head (e.g.", "club head 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, or 2300) at the back end 38 to shift the center of gravity of the club head toward the back end 38.For further example, the coating 50 may be applied to the club head 100, 200 on the sole 24 to shift the center of gravity toward the sole 24.Further still, the coating 50 may be applied to the back end 38 and the sole 24 of the club head to shift the head center of gravity toward the back end 38 and the sole 24.While the examples described herein illustrate the coating 50 positioned to shift the head center of gravity toward the back end 38 and/or the sole 24 of the club head, the coating 50 may be positioned anywhere on the club head to shift the center of gravity in any direction, including toward the crown 18, toward the sole 24, toward the heel 28, toward the toe 34, toward the strike face 10, toward the back end 38, towards at least a portion of the hosel 40, or in any combination of the described directions of the club head to optimize the performance characteristics of the club head.", "The ability to apply the coating 50 uniformly over the club head or in specific portions of the club head at a micro level allows for precise control of the head center of gravity position.", "In many embodiments, the center of gravity of the of club head having coating 50 (e.g.", "club head 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, or 2300), can shift by up to approximately 0.05 inches, 0.15 inches, 0.25 inches, 0.35 inches, 0.45 inches, 0.55 inches, 0.65 inches, 0.75 inches, or up to 85 inches in a direction toward the heel 28, toward the toe 34, toward the sole 24, toward the crown 18, toward the strike face 10, toward the back end 38, or any combination of the described directions, compared to a similar club head without a coating.", "In many embodiments, the coating 50, as described herein, can also increase the moment of inertia of the club head about an x-axis extending through the center of gravity from the heel 28 to the toe 34, and/or about the y-axis extending through the center of gravity from the crown 18 to the sole 24.In general, club head moment of inertia increases as weight or mass is distributed farther from the head center of gravity.", "Applying the coating 50 as described herein, allows for positioning of discretionary weight at increased or maximized distances from the head center of gravity.", "Therefore, the coating 50 of the club head (e.g.", "club head 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, or 2300) may be used to increase and/or maximize the moment of inertia of the club head.", "Increasing the moment of inertia of the club head results in increased consistency in ball direction, trajectory, and distance.", "Therefore, off-center hits will behave more similarly to on-center hits for the club head having the coating 50.In many embodiments, the moment of inertia about the x-axis of the club head having the coating 50 (e.g.", "club head 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, or 2300) can be increased by up to approximately 2.5%, 5%, 7.5%, 10%, 12.5%, 15%, 17.5%, or 20%, compared to a similar club head without a coating.", "In other embodiments, the moment of inertia about the x-axis of the club head having the coating 50 can be increased by approximately 1% to 9%, 2.5% to 5%, 5% to 10%, 5% to 15%, or 10% to 20%, compared to a similar club head without a coating.", "In many embodiments, the moment of inertia about the y-axis of the club head 100, 200 having the coating 50 can be increased by up to approximately 2.5%, 5%, 7.5%, 10%, 12.5%, 15%, 17.5%, or 20%.", "In other embodiments, the moment of inertia about the y-axis of the club head having the coating 50 can be increased by approximately 1% to 11%, 2.5% to 5%, 5% to 10%, 5% to 15%, or 10% to 20% compared to a similar club head without a coating.", "Referring to Tables 2-4 below, the coating material, in combination with the surface area and thickness 56, may be designed to add a desired discretionary weight to the club head (e.g.", "club head 100, 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, 2300).", "For example, Table 2 illustrates exemplary coatings 50 having varying coating material densities, position on the club head (related to surface area), and thicknesses 56 required to add 1 gram of discretionary weight to the club head.", "For a further example, Table 3 illustrates exemplary coatings 50 having varying coating material densities, positions on the club head (related to surface area), and coating thicknesses 56 required to add 5 grams of discretionary weight to the club head.", "For a further example, Table 4 illustrates exemplary coatings 50 having varying coating material densities, positions on the club head (related to surface area), and thicknesses 56 required to add 10 grams of discretionary weight to the club head.", "While the examples illustrated in Tables 2-4 provide exemplary discretionary weights, coating materials, positions, and thicknesses 56 of the coating 50, the same principles apply to add any amount of discretionary weight to the club head, such as, for example, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25 grams of discretionary weight.", "For instance, to add 20 grams of weight to the club head, a tungsten carbide coating, having a density of 256.13, requires a coating thickness of 0.00154 inches across the entire body, 0.0134 inches across the face, 0.00170 across the body, 0.00435 across the crown, 0.00435 across the skirt/sole, or 0.01956 across a portion of the sole over a sole weight.", "Further, the thickness 56 of the coating 50 may be varied for any coating position to adjust the relationship between the coating thickness 56 and coating material, position, and/or discretionary weight.", "TABLE 2 Exemplary coating thicknesses for varying coating materials and positions to add 1 gram of discretionary weight to the club head Coating Position on Club Head and thickness (inches) required for a coating weight of 1 gram Coating Portion of Material Entire the sole Coating Density Club Strike over a sole Material (g/in3) Head face Body Crown Sole weight Ti 8-1-1 71.45 0.00027 0.00233 0.00030 0.00078 0.00078 0.00350 Cobalt 144.70 0.00013 0.00115 0.00015 0.00038 0.00038 0.00173 Beryllium Copper Pure 199.27 0.00010 0.00084 0.00011 0.00028 0.00028 0.00125 Palladium Tungsten 256.13 0.00008 0.00065 0.00008 0.00022 0.00022 0.00098 Carbide Tungsten 314.96 0.00006 0.00053 0.00007 0.00018 0.00018 0.00079 Rhenium Pure 316.27 0.00006 0.00053 0.00007 0.00018 0.00018 0.00079 Tungsten TABLE 3 Exemplary coating thicknesses for varying coating materials and positions to add 5 grams of discretionary weight to the club head Coating Position on Club Head and thickness (inches) required for a coating weight of 5 grams Coating Portion of Material Entire the sole Coating Density Club Strike over a sole Material (g/in3) Head face Body Crown Sole weight Ti 8-1-1 71.45 0.00135 0.01166 0.00152 0.00389 0.00389 0.01749 Cobalt 144.70 0.00066 0.00576 0.00075 0.00192 0.00192 0.00864 Beryllium Copper Pure 199.27 0.00048 0.00418 0.00055 0.00139 0.00139 0.00627 Palladium Tungsten 256.13 0.00038 0.00325 0.00042 0.00108 0.00108 0.00488 Carbide Tungsten 314.96 0.00031 0.00265 0.00035 0.00088 0.00088 0.00397 Rhenium Pure 316.27 0.00030 0.00263 0.00034 0.00088 0.00088 0.00395 Tungsten TABLE 4 Exemplary coating thicknesses for varying coating materials and positions to add 10 grams of discretionary weight to the club head Coating Position on Club Head and thickness (inches) required for a coating weight of 10 grams Coating Portion of Material Entire the sole Coating Density Club Strike over a sole Material (g/in3) Head face Body Crown Sole weight Ti 8-1-1 71.45 0.00269 0.02333 0.00304 0.00788 0.00778 0.03499 Cobalt 144.70 0.00133 0.01152 0.00150 0.00384 0.00384 0.01728 Beryllium Copper Pure 199.27 0.00097 0.00836 0.00109 0.00279 0.00279 0.01255 Palladium Tungsten 256.13 0.00075 0.00651 0.00085 0.00217 0.00217 0.00976 Carbide Tungsten 314.96 0.00061 0.00529 0.00069 0.00176 0.00176 0.00794 Rhenium Pure 316.27 0.00061 0.00527 0.00069 0.00176 0.00176 0.00790 Tungsten As illustrated in Tables 2-4, the coating 50 having a lower coating material density will require a greater thickness 56 than the coating 50 having a higher coating material density to add the same discretionary weight over the same surface area to the club head.", "Similarly, the coating 50 having a higher material coating density will require less thickness 56 than the coating 50 having a lower coating material density to add the same discretionary weight over the same surface area to the club head.", "In general, the coating material density, thickness 56, and/or surface area of the coating 50 may be increased to increase the amount of discretionary weight added to the club head by the coating 50.Similarly, the coating material density, thickness 56, and/or surface area of the coating 50 may be decreased to decrease the amount of discretionary weight added to the club head by the coating 50.Referring to Tables 2-4, the thickness 56 of the coating 50 may range from approximately 0.00001-0.10 inches to add approximately 1-25 grams, 1-20 grams, 1-15 grams, or 1-10 grams of discretionary weight to the club head 100.For example, the thickness 56 of the coating 50 may be approximately 0.00001, 0.000025, 0.00005, 0.000075, 0.0001, 0.00025, 0.0005, 0.00075, 0.001, 0.0025, 0.005, 0.0075, 0.01, 0.025, 0.05, 0.075, or 0.10 inches.", "For further example, the thickness 56 of the coating 50 may add approximately 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25 grams of discretionary weight to the club head 100.Golf Club Head with Surface Roughness Prior to Coating In other embodiments, the club head 2400 similar to the club heads described above (e.g.", "200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, or 2300), comprises of a plurality of coatings 50 including a first coating 501 and a second coating 502.The club head in this exemplary embodiment further comprises a surface roughness 68.The surface roughness 68 of the club head 2400 is formed onto the outer surface 42 of the club head 2400.The surface roughness can be formed on at least a portion of the crown 18, the sole 24, the heel 28, the toe 34, the back end 38, the strike face 10, the hosel 40, or any combination thereof on the outer surface 42 of the club head.", "For example, the surface roughness 68 is formed on the sole 24 near the back end 38, and equidistant from the toe 34 and the heel 28 of the cub head.", "In other examples, the surface roughness 68 is formed in the sole 18 near the back end 38 closer to the heel 28, or closer to the toe 34 of the club head.", "The surface roughness 68 of the club head 2400 comprises a depth downward into the outer surface 42, wherein the depth ranges between 25 micro inches to 100 micro inches, 25 micro inches to 40 micro inches, 40 micro inches to 55 micro inches, 55 micro inches to 70 micro inches, 70 micro inches to 85 micro inches, or 85 micro inches to 100 micro inches.", "For example, the depth of the surface roughness can be 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, or 100 micro inches.", "As described above in FIGS.", "15-18, the first coating 501 of the club head 2400 can be positioned in various locations on the outer surface 42 of the club head.", "For example, the first coating 501 can cover at least a portion of the crown 18, the sole 24, the heel 28, the toe 34, the back end 38, the strike face 10, the hosel 40, or any combination thereof on the outer surface 42 of the club head.", "Similarly, the first coating 501 can cover at least just a portion of the surface roughness 68 formed on any portion of the club head, at least just a portion of the outer surface 42 of the club head, or any combination thereof.", "For example, the first coating 501 can cover at least a portion of the surface roughness 68 formed on the crown 18, and at least a portion of the surface roughness 68 formed on a portion of the sole 24 near the back end 38.In other embodiments, the first coating 501 can cover at least a portion of the surface roughness 68 and at least a portion of the outer surface 42 of the club head.", "For example, the first coating 501 can cover at least a portion of the surface roughness 68 formed on the sole 24 of the club head, and cover at least a portion of the crown 18.In some embodiments, the material of the first coating 501 is a primer.", "The primer can be an oil alkyd primer, a latex primer, or an organic/inorganic zinc primer such as zinc chromate, zinc rich epoxy, urethane zinc, or any other kind of material that can be applied to the body 14 of the club head.", "In other embodiments, the material of the first coating 501 is a non-primer such as a beryllium based alloy, a copper based alloy, a palladium based alloy, a tungsten based alloy, a rhenium based alloy, a cobalt based alloy, a rhodium based alloy, a ruthenium based alloy, a molybdenum based alloy, a nickel based alloy, an iron based alloy, or cadium based alloy.", "In other embodiments still, the material of the first coating 501 can be a pure-based metal such as pure beryllium, pure copper, pure palladium, pure tungsten, pure rhenium, pure cobalt, pure rhodium, pure ruthenium, pure molybdenum, pure nickel, pure iron, or pure cadium.", "As described above in FIGS.", "15-18, the second coating 502 can cover at least a portion of the crown 18, the sole 24, the heel 28, the toe 34, the back end 38, the strike face 10, the hosel 40, or any combination thereof on the outer surface 42 of the club head.", "Further, the second coating 502 can cover at least a portion of just the first coating 501, just the surface roughness 68, just the outer surface 42 of the club head, or a combination thereof.", "For example, the second coating 502 can cover at least a portion of the crown 18.In another example, the second coating 502 can cover at least a portion of the first coating 501 positioned on the surface roughness 68 formed on the sole 24 of the club head.", "In other examples, the second coating 502 can cover at least a portion of the surface roughness 68 formed on the sole 24 near the toe 34 of the club head.", "In some embodiments, the material of the second coating 502 can be any material that can be applied to a club head.", "The material of the second coating 502 can be a beryllium based alloy, a copper based alloy, a palladium based alloy, a tungsten based alloy, a rhenium based alloy, a cobalt based alloy, a rhodium based alloy, a ruthenium based alloy, a molybdenum based alloy, a nickel based alloy, an iron based alloy, or cadium based alloy.", "In other embodiments, the material of the second coating 502 can be a pure-based metal such as pure beryllium, pure copper, pure palladium, pure tungsten, pure rhenium, pure cobalt, pure rhodium, pure ruthenium, pure molybdenum, pure nickel, pure iron, or pure cadium.", "The first coating 501 comprises a density, and the second coating 502 comprises a density.", "The density of the first coating 501 can be different from the density of the second coating 502.In some embodiments, the density of the first coating 501 is less than the density of the second coating 502, while in other embodiments, the density of the first coating 501 is greater than the density of the second coating 502.Still, in other embodiment, the density of the first coating 501 can be the same as the density of the second coating 502.In many embodiments, the plurality of coatings 50, as described above may be used to position discretionary weight to achieve specific head center of gravity positions.", "Adjusting the center of gravity can affect the MOI of the club head, as well as the spin and trajectory of the ball.", "For example, a lower center of gravity near the back end 38, and near the toe 34 can decrease the spin of the ball while maintain a trajectory similar to a club head 2400 having higher loft.", "In one example, the plurality of coatings 50 can be applied to the sole 24 near the back end 38 to shift the center of gravity toward the sole 24 and the back end 38 of the club head.", "Further upon this example, the plurality of coatings 50 can be applied more near the toe 34 to shift the center of gravity toward the toe 34 of the club head.", "In some embodiments, the center of gravity of the club head 2400 can shift from 0.2 inches to 0.48 inches toward the sole 24 of the club head, from 0.01 inches to 0.26 inches toward the back end 38 of the club head, and from 0.005 inches to 0.065 inches toward the toe 34.For example, the center of gravity can shift toward the sole 24 by 0.02 inches, 0.05 inches, 0.10 inches, 0.15 inches, 0.20 inches, 0.25 inches, 0.30 inches, 0.35 inches, 0.40 inches, 0.45 inches, or 0.48 inches; while the center of gravity can further shift toward the back end 38 by 0.01 inches, 0.03 inches, 0.06 inches, 0.09 inches, 0.12 inches, 0.15 inches, 0.18 inches, 0.21 inches, or 0.26 inches; while the center of gravity can further still shift toward the toe 34 by 0.005 inches, 0.010 inches, 0.015 inches, 0.020 inches, 0.025 inches, 0.030 inches, 0.035 inches, 0.040 inches, 0.045 inches, 0.050 inches, 0.055 inches, 0.060 inches, and 0.065 inches compared to a club head 2400 with no coating.", "In one example, the plurality of coatings 50 can be applied to a portion of the sole near the heel or a portion of the sole near the toe.", "In another example, the plurality of coatings 50 can be applied to both a portion of the sole near the heel and a portion of the sole near the toe, as illustrated in FIG.", "12.In some embodiments, the center of gravity of the club head 1200 of FIG.", "12 or the club head 1300 of FIG.", "13 can shift from 0.01 inches to 0.07 inches toward the sole 24 of the club head, from 0.005 inches to 0.10 inches toward the back end 38 of the club head, and from 0.005 inches to 0.055 inches toward the toe 34.For example, the center of gravity can shift toward the sole 24 by 0.01 inches, 0.02 inches, 0.03 inches, 0.04 inches, 0.05 inches, 0.06 inches, or 0.07 inches; while the center of gravity can further shift toward the back end 38 by 0.005 inches, 0.008 inches, 0.010 inches, 0.02 inches, 0.03 inches, 0.04 inches, 0.05 inches, 0.06 inches, 0.07 inches, 0.08 inches, 0.09 inches, or 0.10 inches; while the center of gravity can further still shift toward the toe 34 by 0.005 inches, 0.010 inches, 0.015 inches, 0.020 inches, 0.025 inches, 0.030 inches, 0.035 inches, 0.040 inches, 0.045 inches, 0.050 inches, or 0.055 inches, compared to a club head 1200 or 1300 with no coating.", "In other embodiments of the club heads 1200 and 1300 with the plurality of coatings 50, the center of gravity of the club head 1200 or club head 1300 can shift from 0.005 inches to 0.25 inches toward the strike face 10 of the club head and 0.005 inches to 0.095 inches toward the heel 28.For example, the center of gravity can shift toward the strike face 10 by 0.005 inches, 0.01 inches, 0.03 inches, 0.06 inches, 0.09 inches, or 0.095 inches; while the center of gravity can further shift toward the heel 28 by 0.005 inches, 0.01 inches, 0.02 inches, 0.03 inches, 0.04 inches, 0.05 inches, 0.06 inches, 0.07 inches, 0.08 inches, 0.09 inches, or 0.095 inches, compared to a club head 1200 or 1300 with no coating.", "In many embodiments the plurality of coatings 50 can increase the moment of inertia about the x-axis extending through the center of gravity from the heel 28 to the toe 34, and/or about the y-axis extending through the center of gravity from the crown 18 to the sole 24.Increasing the moment of inertia of the club head 2400 can increase the consistency of ball direction, trajectory, and distance.", "Therefore, the club head 2400 is more forgiving for off-center shots.", "In one example, the plurality of coatings 50 can be applied to the sole 24 near the back end 38, and more near the toe 34 to increase the moment of inertia about the x-axis by 7.5% to 11.0% and increase the moment of inertia about the y-axis by 2.5% to 5.5%.", "For example, the moment of inertia about the x-axis can increase by 7.5%, 7.8%, 8.1%, 8.4%, 8.7%, 9.0%, 9.3%, 9.6%, 9.9%, 10.2%, 10.5%, 10.8%, or 11.0%; while the moment of inertia about the y-axis by 2.5%, 2.8%, 3.1%, 3.4%, 3.7%, 4.0%, 4.3%, 4.6%, 4.9%, 5.2%, or 5.5%, compared to a similar club head 2400 with no coating.", "The plurality of coatings 50 can further affect the statistical area of the club head.", "The statistical area of the club head 2400 is the area in which the ball lands consecutively with the same swing conditions (i.e.", "the swing, the stance, environmental conditions).", "The smaller the statistical area of the club head, the more consistent the shots in where they land.", "More consistent shots allow for a player to better gauge the landing and distance of the ball.", "In some embodiments, the plurality of coatings 50 applied onto the surface roughness can decrease the statistical area of the ball flight ranging from 10% to 24%.", "For example, the statistical area of the ball flight can be 10%, 12%, 14%, 16%, 18%, 20%, 22% or 24%, compared to a similar club head 2400 without a plurality of coatings 50.The plurality of coatings 50 further affects the spin rate of the ball.", "A high ball spin rate increases the chance the ball will roll backwards upon landing, thus losing distance.", "Likewise, the lower the ball spin rate, the lower the chance the ball will roll backwards, but instead roll forward, thus increasing distance.", "The plurality of coatings 50 applied to the club head 2400 decreases the spin rate of the ball by 190 rpm to 230 rpm, while maintaining the same lauch angle as a similar club head 2400 without any coating.", "For example, the plurality of coatings 50 can decrease the ball spin rate by 190 rpm, 195 rpm, 200 rpm, 205 rpm, 210 rpm, 215 rpm, 220 rpm, 225 rpm, or 230 rpm, compared to a similar club head 2400 without any coating.", "FIG.", "20 illustrates a method of manufacturing the club head (e.g.", "club head 100, 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, 2300).", "The method includes providing a club head having a strike face 10 and a body 14 with a crown 18, a sole 24 opposite the crown 18, a heel 28, a toe 34 opposite the heel 28, and a back end 38, and applying at least one coating 50 to at least a portion of the club head 100.The coating 50 may be applied to a surface of the club head by vapor deposition, plasma spray, plating, or spotting.", "The process of applying the coating 50 may involve spraying the club head with a powered material under high pressure at approximately room temperature.", "Further, the coating 50 may be applied to the club head using any other process capable of applying the coating 50 to the club head in a thin layer.", "FIG.", "21 illustrates a method of manufacturing the club head 2400.The method is similar to the method described above of FIG.", "20, but further comprises applying a surface roughness 68 to the outer surface 42 of club head provided 2400 prior to applying a plurality of coatings 50.The process of applying a surface roughness 68 to the outer surface 42 of the club head 2400 may involve grinding, sand, sand blasting, abrasive blasting, laser texturing, or any process of creating surface texture on a club head.", "The outer surface 42 can be roughened using various types of blast media, including but not limited to, beaded titanium and beaded stainless steel alloy.", "In some embodiments, the surface roughness 68 can range from 30 to 180 microinches (μin) deep.", "For example, the surface roughness 68 can be 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 105, 110, 115, 120, 125, 130, 135, 140, 145, 150, 155, 160, 165, 170, 175, or 180 μin deep.", "The methods of manufacturing and providing a club head club head of FIGS.", "20 and 21 may comprise polishing the head after casting to remove excess gate material and clean the surface.", "Polishing can further help remove surface porosity.", "In some embodiments of the methods, before application of the coating, at least a portion of the club head's outer surface 42 is cleaned using air to remove excess media and dust.", "In other embodiments of the methods, before application of the coating, at least a portion of the club head's outer surface 42 is cleaned using liquid to remove excess media and dust.", "The cleaning liquid may comprise acetone, isopropyl alcohol, or any other suitable liquid.", "In other embodiments of the methods, any suitable cleaning mechanism can be employed to remove excess media and dust.", "Furthermore, in some embodiments of the methods of manufacturing, a target area is masked with guiding tape before the layers are applied to the target area.", "The method of manufacturing club head of FIGS.", "20 and 21 may also be used to manufacture club head 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, 2300, and 2400 by repeating the process of applying the coating for the second coating, third coating, fourth coating, and/or fifth coating of the club head.", "Further, the method of manufacturing the club head is merely exemplary and is not limited to the embodiments presented herein.", "The method can be employed in many different embodiments or examples not specifically depicted or described herein.", "In some embodiments, the processes of the method described can be performed in any suitable order.", "In other embodiments, one or more of the processes may be combined, separated, or skipped.", "In the illustrated embodiments, the club heads (e.g.", "club head 100, 200, 300, 400, 500, 600, 700, 800, 900, 1100, 1200, 1300, 1400, 2000, 2100, 2200, 2300, 2400) are shown as a wood-type club head.", "However, the club head may be any type of club head including a wood-type club head (e.g., driver or fairway wood), an iron-type club head (e.g., iron or wedge), or a putter-type club head.", "Further, the embodiments described herein illustrate the club head having the coating on the outer surface 42 of the club head.", "In other embodiments, the coating may be applied to the inner surface 46 of the club head to achieve similar results.", "EXAMPLES Example 1 Referring to FIGS.", "10A and 10B, an exemplary club head 900 having the coating 50 comprising tungsten carbide (density of approximately 256.13 g/in3), with a first portion positioned over the entire crown 18 and a second portion positioned over the entire sole 24, each portion having a thickness 56 of approximately 0.001 inches, and adding a total of approximately 9.9 grams of weight to the club head 900 shifted the center of gravity approximately 0.076 inches toward the toe 34, approximately 0.050 inches toward the crown 18, and approximately 0.020 inches toward the back end 38, compared to a similar club head without the coating.", "Further, in this example, the coating 50 increased the moment of inertia about the x-axis by approximately 5.3%, and increased the moment of inertia about the y-axis by approximately 4.5%, compared to a similar club head without the coating.", "Example 2 Referring to FIG.", "11, an exemplary club head 1100 having the coating 50 comprising tungsten carbide (density of approximately 256.13 g/in3), positioned over the entire sole 24, having a thickness 56 of approximately 0.009 inches, and adding approximately 11.4 grams of weight to the club head 1100 shifted the center of gravity by approximately 0.014 inches toward the toe 34, approximately 0.055 inches toward the sole 24, and approximately 0.085 inches toward the back end 38, compared to a similar club head without the coating.", "Further, in this example, the coating 50 increased moment of inertia about the x-axis by approximately 8.1%, and increased the moment of inertia about the y-axis by approximately 8.6%, compared to a similar club head without the coating.", "Example 3 Referring to FIG.", "12, an exemplary club head 1200 having the coating 50 comprising tungsten carbide (density of approximately 256.13 g/in3), with a first portion positioned over the a portion of the sole 24 near the toe 34 and a second portion positioned over a portion of the sole 24 near the heel 28, each portion having a thickness 56 of approximately 0.006 inches, and adding a total of approximately 8.2 grams of weight to the club head shifted the center of gravity by approximately 0.045 inches toward the toe 34, approximately 0.010 inches toward the sole 24, and approximately 0.020 inches toward the back end 38, compared to a similar club head without the coating.", "Further, in this example, the coating 50 increased the moment of inertia about the x-axis by approximately 2.2%, and increased the moment of inertia about the y-axis by approximately 3.5%, compared to a similar club head without the coating.", "Example 4 Referring to FIG.", "13, an exemplary club head 1300 having the coating 50 comprising tungsten carbide (density of approximately 256.13 g/in3), positioned over a portion of the sole 24 near the heel 28, having a thickness 56 of approximately 0.009 inches, and adding approximately 9.0 grams of weight to the club head 1300 shifted the center of gravity by approximately 0.082 inches toward the heel 28, approximately 0.010 inches toward the sole 24, and approximately 0.190 inches toward the strike face 10, compared to a similar club head without the coating.", "Further, in this example, the coating 50 increased the moment of inertia about the x-axis by approximately 5.5%, and increased the moment of inertia about the y-axis to approximately 2.7%, compared to a similar club head without the coating.", "Example 5 Referring to FIG.", "14, an exemplary club head 1400 having the coating 50 comprising tungsten carbide (density of approximately 256.13 g/in3), positioned over the entire sole 24, having a thickness 56 of approximately 0.002 inches, and adding approximately 10.3 grams of weight to the club head 1300 shifted the center of gravity by approximately 0.010 inches toward the toe 34, approximately 0.055 inches toward the sole 24, and approximately 0.050 inches toward the back end 38, compared to a similar club head without the coating.", "Further, in this embodiment, the coating 50 increased the moment of inertia about the x-axis by approximately 4.2%, and increased the moment of inertia about the y-axis by approximately 4.4%, compared to a similar club head without the coating.", "Example 6 Referring to FIG.", "19, an exemplary club head 2400, comprising a surface roughness 68 formed on the sole 24 near the back end 38, further comprises a first coating 501 covering the surface roughness 68, and further still comprising a second coating 502, covering the first coating 502 adds approximately 10.9 grams of weight to the club head.", "The added weight by the first and second coating 501 and 502 at that distinct location shifted the center of gravity of the club head by approximately 0.042 inches toward the toe 34, approximately 0.28 inches toward the sole 24, and approximately 0.11 inches toward the back end 38, compared to a similar club head 2400 with the surface roughness and coating.", "Further in this embodiment, the first and second coating 501 and 502 increased the moment of inertia about the x-axis by approximately 7.7%, and increased the moment of inertia about the y-axis by approximately 4.3%, compared to a similar club head without the surface roughness and coating.", "Further still in this embodiment, the first and second coating 501 and 502 comprised a 17% smaller statistic area, and a 215 rpm less spin with a similar launch angle, compared to a club head without the surface roughness, and coating.", "Example 7 Referring to FIG.", "11, a first exemplary embodiment of the club head 1100, further comprises a surface roughness 68 (not shown in FIG.", "11) formed on the sole 24 near the back end 38.The club head 1100 further comprises a first coating 501 covering the surface roughness 68, and further still comprising a second coating 502 covering the first coating 501, together adding approximately 10.0 grams of weight to the club head.", "For example, the first coating comprises a primer and the second coating comprises a high density material.", "In a second exemplary embodiment of the club head 1100, only a first coating 501 is applied over the surface roughness 68, adding approximately 10.0 grams of weight to the club head.", "For example, the first coating 501 comprises a high density material, and no primer is applied between the club head and the first coating 501.According to a test that compared three control heads to three heads of the first exemplary embodiment and to three heads of the second exemplary embodiment, the center of gravity of the club head was shifted further toward the toe 34, lower toward the sole 24, and further toward the back end 38.Table 5 below shows the averages of the CG locations as measured with an x-coordinate axis extending positively from the center of mass towards the heel of the club head and parallel to the ground plane, a y-coordinate axis extending positively from the center of the sole towards the crown and perpendicular to the ground plane, and a z-coordinate axis extending positively rearward from the club strike face and parallel to the ground plane.", "The results show that, on average, the added weight of the first and second coating 501 and 502 of the first exemplary embodiment at the distinct rear location shifted the center of gravity of the club head by approximately 0.020 inches toward the toe 34, approximately 0.140 inches toward the sole 24, and approximately 0.076 inches toward the back end 38, compared to a similar club head 1100 with no coating.", "This shift in the center of gravity improves performance characteristics of the golf club.", "The test results also showed that, on average, the added weight of the first coating 501 of the second exemplary embodiment, at the distinct rear location, shifted the center of gravity of the club head by approximately 0.034 inches toward the toe 34, approximately 0.047 inches toward the sole 24, and approximately 0.080 inches toward the back end 38.Testing shows that this shift in the center of gravity increased the carry yard distance by 0.9 yards, as expected from the center of gravity data.", "TABLE 5 Exemplary locations of CG position within various embodiments Type of club head X-axis CG Y-axis CG Z-axis CG First exemplary embodiment −0.0053 0.92 1.836 (with primer and high density layer) Second exemplary embodiment −0.007 1.013 1.840 (with high density layer) Control club head 0.028 1.060 1.760 The spin rate was shown to decrease by 6.7% for the second exemplary embodiment.", "The second exemplary embodiment showed a spin rate of 2983 rpms as compared to a spin rate of 3198 rpms for the control club.", "The lower spin rate reduces unwanted roll once the ball lands on the ground, which results in a player hitting more accurate shots.", "The statistical area, representing the area within which test shots land, for the second exemplary embodiment, covers around 1009 square yards, which is 14.5% less area than is covered by a similar control club.", "The statistical area for a similar control club head covers around 1180 square yards.", "This test shows that a first coating on a portion of the sole 24 near the rear increases the performance precision of a golf club head, allowing a player to hit more consistent shots.", "Replacement of one or more claimed elements constitutes reconstruction and not repair.", "Additionally, benefits, other advantages, and solutions to problems have been described with regard to specific embodiments.", "The benefits, advantages, solutions to problems, and any element or elements that may cause any benefit, advantage, or solution to occur or become more pronounced, however, are not to be construed as critical, required, or essential features or elements of any or all of the claims.", "As the rules to golf may change from time to time (e.g., new regulations may be adopted or old rules may be eliminated or modified by golf standard organizations and/or governing bodies such as the United States Golf Association (USGA), the Royal and Ancient Golf Club of St. Andrews (R&A), etc.", "), golf equipment related to the apparatus, methods, and articles of manufacture described herein may be conforming or non-conforming to the rules of golf at any particular time.", "Accordingly, golf equipment related to the apparatus, methods, and articles of manufacture described herein may be advertised, offered for sale, and/or sold as conforming or non-conforming golf equipment.", "The apparatus, methods, and articles of manufacture described herein are not limited in this regard.", "While the above examples may be described in connection with a driver-type golf club, the apparatus, methods, and articles of manufacture described herein may be applicable to other types of golf club such as a fairway wood-type golf club, a hybrid-type golf club, an iron-type golf club, a wedge-type golf club, or a putter-type golf club.", "Alternatively, the apparatus, methods, and articles of manufacture described herein may be applicable other type of sports equipment such as a hockey stick, a tennis racket, a fishing pole, a ski pole, etc.", "Moreover, embodiments and limitations disclosed herein are not dedicated to the public under the doctrine of dedication if the embodiments and/or limitations: (1) are not expressly claimed in the claims; and (2) are or are potentially equivalents of express elements and/or limitations in the claims under the doctrine of equivalents.", "Various features and advantages of the disclosure are set forth in the following claims." ] ]
Patent_15872733
[ [ "NEURAL SLEEVE FOR NEUROMUSCULAR STIMULATION, SENSING AND RECORDING", "The present disclosure relates to neuromuscular stimulation and sensing cuffs.", "The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger.", "More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component.", "One or more electrodes are housed within the reusable component.", "The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit.", "The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement." ], [ "1.A device for neuromuscular stimulation, comprising: a reusable sleeve; and one or more electrodes housed within the reusable sleeve.", "2.The device of claim 1, wherein the reusable sleeve comprises at least two flexible fingers along which the one or more electrodes are located, the flexible fingers extending in the same direction from a first connector, and one or more conductive mediums disposed on each flexible finger.", "3.The device of claim 2, wherein the conductive medium comprises a hydrogel, a lotion, or a conductive polymer.", "4.The device of claim 2, wherein the at least two flexible conductive pathways can be wrapped helically.", "5.The device of claim 2, further comprising a fabric layer disposed on an exterior of the reusable sleeve.", "6.The device of claim 2, wherein each flexible finger includes a conductive circuit layer.", "7.The device of claim 6, wherein each flexible finger includes an insulating base layer upon which the conductive circuit layer is laid.", "8.The device of claim 6, wherein each flexible finger includes an insulating cover layer over the conductive circuit layer.", "9.The device of claim 2, wherein each flexible finger includes a plurality of hydrogel discs disposed over each electrode.", "10.The device of claim 9, wherein the rigidizer interfaces with a processing device.", "11.The device of claim 2, having the first connector and a second connector, wherein at least two additional flexible fingers also extend from the second connector in the same direction as the flexible fingers extending from the first connector; and at least one webbing connects a flexible finger extending from the first connector to a flexible finger extending from the second connector.", "12.The device of claim 11, wherein the flexible fingers taper towards a center axis of the reusable sleeve.", "13.The device of claim 11, wherein each flexible finger includes: a non-electrode-containing portion; and a scalloped, electrode-containing portion distal from the connector.", "14.The device of claim 13, wherein each flexible finger further includes a non-scalloped, electrode-containing portion.", "15.The device of claim 11, wherein at least one flexible finger comprises: a first portion which is transverse to a center axis of the reusable sleeve; and a second portion which is parallel to the center axis of the reusable sleeve.", "16.The device of claim 1, comprising an inner disposable sleeve, the inner disposable sleeve comprising a conductive medium in contact with the multiple electrodes.", "17.The device of claim 16, wherein the conductive medium comprises a hydrogel which is relatively more conductive in a z-direction than in a x-direction or a y-direction.", "18.The device of claim 16, wherein: the conductive medium is less conductive in a regular state; and the conductive medium becomes more conductive upon application of external pressure in a direction of the external pressure.", "19.The device of claim 18, wherein the conductive medium comprises a compressible polymer and a conductive filler dispersed in the compressible polymer.", "20.The device of claim 19, wherein the conductive filler comprises carbon fibers, carbon nanotubes, or metallic particles.", "21.The device of claim 16, wherein the conductive medium is dry in an initial state and becomes tacky upon any one of: application of an electrical current; a change in temperature; a change in pH; or a change in moisture; or wherein the conductive medium comprises a stimuli-sensitive polymer.", "22.The device of claim 1, wherein each electrode of the multiple electrodes includes concentric rows of teeth about 200 μm to about 300 μm in height.", "23.The device of claim 1, wherein the reusable sleeve comprises a flexible material.", "24.The device of claim 1, wherein the reusable sleeve comprises: a rigid shell; and a hinge running parallel to a longitudinal axis of the reusable sleeve.", "25.The device of claim 1, wherein the reusable sleeve comprises a user interface for selectively configuring electrodes and adjusting stimulation level or pattern.", "26.The device of claim 25, wherein the reusable sleeve comprises buttons including light emitting diode (LED) based touchscreen displays on a back side of each of the multiple electrodes.", "27.The device of claim 1, wherein the reusable sleeve comprises an accelerometer; and is configured for gesture control of devices.", "28.The device of claim 1, wherein the reusable sleeve is expandable.", "29.The device of claim 1, wherein the reusable sleeve comprises a compression sleeve fabric on which the multiple electrodes are printed using silk-screen technology employing conductive polycellulose or silver/carbon-based ink.", "30.The device of claim 29, further comprising a conductive pathway including an accelerometer.", "31.The device of claim 1, wherein the reusable sleeve comprises a flexible circuit including electrodes connected by electrode traces that (i) house sensors and (ii) the electrode traces are arranged in a zig-zag pattern.", "32.The device of claim 31, wherein the sensors comprise any combination of pressure sensors; strain gauges; accelerometers; a micro-electro-mechanical system (MEMS) including a 3-axis accelerometer and 3-axis magnetometer; a capacitive sensor including a flexible insulating dielectric layer sandwiched between flexible electrodes; a stretch sensor including a material that changes electrical resistance when stretched or strained; a resonant bend sensor including a resistance-inductance-capacitance (RLC) circuit; a sensor including at least one bladder configured to hold a fluid or air; a fiber optic cable and a measurement tool configured to measure a bend in the fiber optic cable based on a frequency or attenuation change in a signal of the fiber optic cable; and a video motion tracking system configured to track a marker of the reusable sleeve.", "33.The device of claim 1, wherein the reusable sleeve comprises conductive fibers and a dry fit material.", "34.The device of claim 1, wherein the reusable sleeve is in the form of a fingerless glove.", "35.The device of claim 1, wherein the multiple electrodes are woven into the reusable sleeve using conductive threads.", "36.The device of claim 1, wherein the reusable sleeve is configured to: cover both a leg portion and a foot portion of a patient; and support gait-training.", "37.The device of claim 1, wherein the reusable sleeve comprises a shirt configured to deliver electrical stimulation to a backside of a patient.", "38.The device of claim 1, wherein the multiple electrodes are configured to both deliver electrical simulation and sense a neural signal of a patient." ], [ "<SOH> BACKGROUND <EOH>The following relates generally to systems, methods and devices for neuromuscular stimulation, sensing, and recording.", "Generally, the system may be used to receive thought signals indicative of an intended action and provide electrical stimulation to nerves and/or muscles to effectuate the intended action, thereby bypassing or assisting a damaged or degenerated region/pathway of the nervous system.", "The devices of the present disclosure are neuromuscular stimulation cuffs, also referred to herein as “neural sleeves,” which deliver stimulation to restore movement to parts of the body not under volitional control due to damaged or degenerated neural regions/pathways from brain or spinal cord injury, stroke, nerve damage, motor neural disease, and other conditions or injuries.", "The system can also be used in a patient that has some local neural or muscle degeneration for therapeutic or rehabilitation purposes.", "Subcutaneous implantable neurostimulation cuffs have been commonly used to block pain and to restore function to damaged or degenerative neural pathways.", "These implantable cuffs are wrapped around a target nerve and generally include one or more electrodes arranged to stimulate the nerve.", "By including more than one electrode and/or a different geometry of electrodes, implantable cuffs such as the flat interface nerve electrode (FINE) have been able to achieve stimulation selectivity at the level of individual nerve vesicles.", "Transcutaneous neurostimulation cuffs behave similarly to implantable cuffs, however there are important differences.", "Because the electrodes are placed on the surface of the skin, rather than below it, stimulation often can better target skeletal muscle tissue or muscle groups, rather than peripheral nerves located deeper under the skin.", "Muscular stimulation may be preferable to stimulating major peripheral nerves, e.g.", "ulnar, median, radial nerves, as stimulating these nerves may cause a patient to feel a tingling sensation and it is more difficult to effect the desired movement.", "By increasing the number and layout of electrodes in a neuromuscular cuff, similar to the direction taken with implanted nerve cuff designs, current generation neuromuscular stimulation cuffs have been able to selectively stimulate individual muscles or muscle groups and achieve finer movements such as individual finger flexing and extension.", "Flexible-like transcutaneous cuffs have been developed which fit around a human appendage such as a forearm to control the wrist or fingers.", "These flexible cuffs may include sensors which record muscle activity, or electromyography (EMG) signals, and stimulate in response to the EMG signals.", "Thin film technologies have also become important in the development of functional electrostimulation (FES) devices.", "Devices incorporating thin film technology are often based on a polyimide substrate covered by a chromium, gold, or platinum film.", "Current transcutaneous neuromuscular stimulation electrodes (or patches) present many limitations.", "Such neuromuscular patches are typically large (several cm across or more) and have a single electrode (conductive surface).", "This does not allow selective stimulation of small muscles segments for fine wrist and finger control.", "It would be desirable to provide improved devices for neuromuscular stimulation.", "Flexible sleeves with multiple small electrodes would allow programmable spatial stimulation patterns, which is highly desirable when attempting to restore complex muscular movements through neuromuscular stimulation." ], [ "<SOH> BRIEF DESCRIPTION <EOH>The present disclosure relates to systems, methods, and devices for thought-controlled neuromuscular stimulation.", "Included is a neuromuscular stimulation cuff (i.e.", "“neural sleeve”) which receives a thought signal indicative of an intended action, and in response, stimulates a damaged region/pathway of the nervous system to effectuate the intended action.", "The neuromuscular cuff may include a flexible design, e.g., including a plurality of electrodes arranged on flexible fingers.", "The flexible fingers allow for variable sized neuromuscular regions, e.g.", "paralyzed limbs, to fit within the neuromuscular cuff.", "The fingers may also allow for increased electrode positioning choices for reanimation of complex muscle movements.", "The neuromuscular cuff may further include an array of electrogel discs which provide enhanced electrical contact as well as keep the cuff adhered to the skin during stimulation-induced movement.", "In yet other embodiments, a device for neuromuscular stimulation includes a flexible printed circuit board having at least one finger and a plurality of electrogel discs disposed on the at least one finger.", "In additional different embodiments, a method for producing a neuromuscular cuff includes providing a layer of polyimide, etching a conductive copper circuit including a plurality of electrodes into the layer of polyimide to form an etched circuit layer, adhering a cover layer onto the etched circuit layer to form a flexible printed circuit board (PCB), and cutting at least one finger from the flexible PCB.", "In other embodiments disclosed herein, devices for neuromuscular stimulation include: a reusable sleeve; and one or more electrodes housed within the reusable sleeve.", "In particular embodiments, the reusable sleeve comprises at least two flexible fingers along which the one or more electrodes are located, each flexible finger extending in the same direction from a connector.", "Each finger contains one or more flexible conductive pathways that lead to the electrode(s) previously described.", "A plurality of conductive mediums is disposed on the flexible fingers to conduct the electrical impulses from the electrodes.", "As a result, each flexible finger is able to conform to different arm profiles and accommodate twisting of the arm.", "The conductive medium may comprise a hydrogel, a lotion, or a conductive polymer.", "The flexible fingers may be oriented with respect to the connector so that they can be wrapped helically (e.g.", "around a patient's limb).", "The device may further comprise a fabric layer disposed on an exterior of the reusable sleeve.", "Each flexible finger may include a conductive circuit layer, which can be arranged in the form of one or more conductive pathways.", "That conductive circuit layer may be laid upon an insulating base layer, for example made of a polyimide.", "The flexible finger may include an insulating cover layer over the conductive circuit layer.", "The flexible finger may include a plurality of hydrogel discs disposed over each electrode, wherein each hydrogel disk is independently connected to a rigidizer.", "The rigidizer may interface with a processing device, such as a computer or other electronic device.", "In other embodiments, a device for neuromuscular stimulation includes: a reusable sleeve; multiple electrodes housed within the reusable sleeve; and an inner disposable sleeve, the inner disposable sleeve comprising a conductive medium in contact with the multiple electrodes.", "The conductive medium may comprise a hydrogel which is relatively more conductive in a z-direction than in a x-direction or a y-direction.", "The conductive medium may be less conductive in a regular state; and the conductive medium may become more conductive upon application of external pressure in a direction of the external pressure.", "The conductive medium may include a compressible polymer and a conductive filler dispersed in the compressible polymer.", "The conductive filler may be carbon-based and comprise carbon fibers.", "The conductive filler may comprise any of: carbon fibers, carbon nanotubes, or metallic particles (e.g.", "silver; gold; platinum; or palladium).", "The conductive medium may be dry in an initial state and then become tacky upon any one of: application of an electrical current; a change in temperature; a change in pH; or a change in moisture.", "The conductive medium may include a stimuli-sensitive polymer.", "Each electrode of the multiple electrodes may include concentric rows of teeth about 200 μm to about 300 μm in height.", "The reusable sleeve may include a flexible material.", "In other embodiments, the reusable sleeve may include: a rigid shell; and a hinge running parallel to a longitudinal axis of the reusable sleeve.", "Sometimes, the reusable sleeve may include a user interface for selectively configuring electrodes and adjusting stimulation level or pattern.", "The reusable sleeve may be expandable.", "In other embodiments, the reusable sleeve may include a compression sleeve fabric on which the multiple electrodes are printed using silk-screen technology employing conductive polycellulose or silver/carbon-based ink.", "The device may further include a conductive pathway including an accelerometer.", "The reusable sleeve may include a flexible circuit which may include electrodes connected by electrode traces; the electrode traces may house sensors; and the electrode traces may be arranged in a zig-zag pattern to enhance flexibility and/or durability.", "The sensors may include any combination of pressure sensors; strain gauges; accelerometers; a micro-electro-mechanical system (MEMS) including a 3-axis accelerometer and 3-axis magnetometer; a capacitive sensor including a flexible insulating dielectric layer sandwiched between flexible electrodes; a stretch sensor including a material that changes electrical resistance when stretched or strained; a resonant bend sensor including a resistance-inductance-capacitance (RLC) circuit; a sensor including at least one bladder configured to hold a fluid or air; a fiber optic cable and a measurement tool configured to measure a bend in the fiber optic cable based on a frequency or attenuation change in a signal of the fiber optic cable; and a video motion tracking system configured to track a marker of the reusable sleeve.", "The reusable sleeve may include conductive/carbon fibers and a dry fit material.", "The reusable sleeve may be in the form of a fingerless glove made of a stretchy material.", "The multiple electrodes may be woven into the reusable sleeve using conductive threads.", "The reusable sleeve may include buttons including light emitting diode (LED) based touchscreen displays on a back side of each of the multiple electrodes.", "The reusable sleeve may include an accelerometer, and may be configured for gesture control of devices.", "The reusable sleeve may be configured to cover both a leg portion and a foot portion of a patient; and support gait-training.", "The reusable sleeve may include a shirt configured to deliver electrical stimulation to a backside of a patient.", "The multiple electrodes may be configured to both deliver electrical simulation and sense a neural signal of a patient.", "In another aspect, a device for neuromuscular stimulation may include: a reusable sleeve; and multiple electrodes housed within the reusable sleeve; wherein the reusable sleeve comprises at least two flexible fingers for housing the multiple electrodes, the flexible fingers extending in the same direction, and a plurality of conductive mediums disposed thereon.", "In another aspect, a device for neuromuscular stimulation includes: a reusable sleeve comprising a continuous substrate; and multiple electrodes housed within the reusable sleeve; wherein the continuous substrate comprises a non-conductive portion and conductive, parallel pathways.", "These and other non-limiting aspects of the present disclosure are discussed in more detail below." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "14/728,512, filed Jun.", "2, 2015, now U.S. Pat.", "No.", "//insert later//, which was a continuation-in-part of U.S. patent application Ser.", "No.", "14/649,025, filed on Jun.", "2, 2015, now U.S. Pat.", "No.", "//insert later//, which was a 371 of PCT Application No.", "PCT/US2013/073247, filed on Dec. 5, 2013, which claimed priority to both U.S.", "Provisional Patent Application Ser.", "No.", "61/733,736, filed on Dec. 5, 2012, and to U.S.", "Provisional Patent Application Ser.", "No.", "61/734,150, filed on Dec. 6, 2012.BACKGROUND The following relates generally to systems, methods and devices for neuromuscular stimulation, sensing, and recording.", "Generally, the system may be used to receive thought signals indicative of an intended action and provide electrical stimulation to nerves and/or muscles to effectuate the intended action, thereby bypassing or assisting a damaged or degenerated region/pathway of the nervous system.", "The devices of the present disclosure are neuromuscular stimulation cuffs, also referred to herein as “neural sleeves,” which deliver stimulation to restore movement to parts of the body not under volitional control due to damaged or degenerated neural regions/pathways from brain or spinal cord injury, stroke, nerve damage, motor neural disease, and other conditions or injuries.", "The system can also be used in a patient that has some local neural or muscle degeneration for therapeutic or rehabilitation purposes.", "Subcutaneous implantable neurostimulation cuffs have been commonly used to block pain and to restore function to damaged or degenerative neural pathways.", "These implantable cuffs are wrapped around a target nerve and generally include one or more electrodes arranged to stimulate the nerve.", "By including more than one electrode and/or a different geometry of electrodes, implantable cuffs such as the flat interface nerve electrode (FINE) have been able to achieve stimulation selectivity at the level of individual nerve vesicles.", "Transcutaneous neurostimulation cuffs behave similarly to implantable cuffs, however there are important differences.", "Because the electrodes are placed on the surface of the skin, rather than below it, stimulation often can better target skeletal muscle tissue or muscle groups, rather than peripheral nerves located deeper under the skin.", "Muscular stimulation may be preferable to stimulating major peripheral nerves, e.g.", "ulnar, median, radial nerves, as stimulating these nerves may cause a patient to feel a tingling sensation and it is more difficult to effect the desired movement.", "By increasing the number and layout of electrodes in a neuromuscular cuff, similar to the direction taken with implanted nerve cuff designs, current generation neuromuscular stimulation cuffs have been able to selectively stimulate individual muscles or muscle groups and achieve finer movements such as individual finger flexing and extension.", "Flexible-like transcutaneous cuffs have been developed which fit around a human appendage such as a forearm to control the wrist or fingers.", "These flexible cuffs may include sensors which record muscle activity, or electromyography (EMG) signals, and stimulate in response to the EMG signals.", "Thin film technologies have also become important in the development of functional electrostimulation (FES) devices.", "Devices incorporating thin film technology are often based on a polyimide substrate covered by a chromium, gold, or platinum film.", "Current transcutaneous neuromuscular stimulation electrodes (or patches) present many limitations.", "Such neuromuscular patches are typically large (several cm across or more) and have a single electrode (conductive surface).", "This does not allow selective stimulation of small muscles segments for fine wrist and finger control.", "It would be desirable to provide improved devices for neuromuscular stimulation.", "Flexible sleeves with multiple small electrodes would allow programmable spatial stimulation patterns, which is highly desirable when attempting to restore complex muscular movements through neuromuscular stimulation.", "BRIEF DESCRIPTION The present disclosure relates to systems, methods, and devices for thought-controlled neuromuscular stimulation.", "Included is a neuromuscular stimulation cuff (i.e.", "“neural sleeve”) which receives a thought signal indicative of an intended action, and in response, stimulates a damaged region/pathway of the nervous system to effectuate the intended action.", "The neuromuscular cuff may include a flexible design, e.g., including a plurality of electrodes arranged on flexible fingers.", "The flexible fingers allow for variable sized neuromuscular regions, e.g.", "paralyzed limbs, to fit within the neuromuscular cuff.", "The fingers may also allow for increased electrode positioning choices for reanimation of complex muscle movements.", "The neuromuscular cuff may further include an array of electrogel discs which provide enhanced electrical contact as well as keep the cuff adhered to the skin during stimulation-induced movement.", "In yet other embodiments, a device for neuromuscular stimulation includes a flexible printed circuit board having at least one finger and a plurality of electrogel discs disposed on the at least one finger.", "In additional different embodiments, a method for producing a neuromuscular cuff includes providing a layer of polyimide, etching a conductive copper circuit including a plurality of electrodes into the layer of polyimide to form an etched circuit layer, adhering a cover layer onto the etched circuit layer to form a flexible printed circuit board (PCB), and cutting at least one finger from the flexible PCB.", "In other embodiments disclosed herein, devices for neuromuscular stimulation include: a reusable sleeve; and one or more electrodes housed within the reusable sleeve.", "In particular embodiments, the reusable sleeve comprises at least two flexible fingers along which the one or more electrodes are located, each flexible finger extending in the same direction from a connector.", "Each finger contains one or more flexible conductive pathways that lead to the electrode(s) previously described.", "A plurality of conductive mediums is disposed on the flexible fingers to conduct the electrical impulses from the electrodes.", "As a result, each flexible finger is able to conform to different arm profiles and accommodate twisting of the arm.", "The conductive medium may comprise a hydrogel, a lotion, or a conductive polymer.", "The flexible fingers may be oriented with respect to the connector so that they can be wrapped helically (e.g.", "around a patient's limb).", "The device may further comprise a fabric layer disposed on an exterior of the reusable sleeve.", "Each flexible finger may include a conductive circuit layer, which can be arranged in the form of one or more conductive pathways.", "That conductive circuit layer may be laid upon an insulating base layer, for example made of a polyimide.", "The flexible finger may include an insulating cover layer over the conductive circuit layer.", "The flexible finger may include a plurality of hydrogel discs disposed over each electrode, wherein each hydrogel disk is independently connected to a rigidizer.", "The rigidizer may interface with a processing device, such as a computer or other electronic device.", "In other embodiments, a device for neuromuscular stimulation includes: a reusable sleeve; multiple electrodes housed within the reusable sleeve; and an inner disposable sleeve, the inner disposable sleeve comprising a conductive medium in contact with the multiple electrodes.", "The conductive medium may comprise a hydrogel which is relatively more conductive in a z-direction than in a x-direction or a y-direction.", "The conductive medium may be less conductive in a regular state; and the conductive medium may become more conductive upon application of external pressure in a direction of the external pressure.", "The conductive medium may include a compressible polymer and a conductive filler dispersed in the compressible polymer.", "The conductive filler may be carbon-based and comprise carbon fibers.", "The conductive filler may comprise any of: carbon fibers, carbon nanotubes, or metallic particles (e.g.", "silver; gold; platinum; or palladium).", "The conductive medium may be dry in an initial state and then become tacky upon any one of: application of an electrical current; a change in temperature; a change in pH; or a change in moisture.", "The conductive medium may include a stimuli-sensitive polymer.", "Each electrode of the multiple electrodes may include concentric rows of teeth about 200 μm to about 300 μm in height.", "The reusable sleeve may include a flexible material.", "In other embodiments, the reusable sleeve may include: a rigid shell; and a hinge running parallel to a longitudinal axis of the reusable sleeve.", "Sometimes, the reusable sleeve may include a user interface for selectively configuring electrodes and adjusting stimulation level or pattern.", "The reusable sleeve may be expandable.", "In other embodiments, the reusable sleeve may include a compression sleeve fabric on which the multiple electrodes are printed using silk-screen technology employing conductive polycellulose or silver/carbon-based ink.", "The device may further include a conductive pathway including an accelerometer.", "The reusable sleeve may include a flexible circuit which may include electrodes connected by electrode traces; the electrode traces may house sensors; and the electrode traces may be arranged in a zig-zag pattern to enhance flexibility and/or durability.", "The sensors may include any combination of pressure sensors; strain gauges; accelerometers; a micro-electro-mechanical system (MEMS) including a 3-axis accelerometer and 3-axis magnetometer; a capacitive sensor including a flexible insulating dielectric layer sandwiched between flexible electrodes; a stretch sensor including a material that changes electrical resistance when stretched or strained; a resonant bend sensor including a resistance-inductance-capacitance (RLC) circuit; a sensor including at least one bladder configured to hold a fluid or air; a fiber optic cable and a measurement tool configured to measure a bend in the fiber optic cable based on a frequency or attenuation change in a signal of the fiber optic cable; and a video motion tracking system configured to track a marker of the reusable sleeve.", "The reusable sleeve may include conductive/carbon fibers and a dry fit material.", "The reusable sleeve may be in the form of a fingerless glove made of a stretchy material.", "The multiple electrodes may be woven into the reusable sleeve using conductive threads.", "The reusable sleeve may include buttons including light emitting diode (LED) based touchscreen displays on a back side of each of the multiple electrodes.", "The reusable sleeve may include an accelerometer, and may be configured for gesture control of devices.", "The reusable sleeve may be configured to cover both a leg portion and a foot portion of a patient; and support gait-training.", "The reusable sleeve may include a shirt configured to deliver electrical stimulation to a backside of a patient.", "The multiple electrodes may be configured to both deliver electrical simulation and sense a neural signal of a patient.", "In another aspect, a device for neuromuscular stimulation may include: a reusable sleeve; and multiple electrodes housed within the reusable sleeve; wherein the reusable sleeve comprises at least two flexible fingers for housing the multiple electrodes, the flexible fingers extending in the same direction, and a plurality of conductive mediums disposed thereon.", "In another aspect, a device for neuromuscular stimulation includes: a reusable sleeve comprising a continuous substrate; and multiple electrodes housed within the reusable sleeve; wherein the continuous substrate comprises a non-conductive portion and conductive, parallel pathways.", "These and other non-limiting aspects of the present disclosure are discussed in more detail below.", "BRIEF DESCRIPTION OF THE DRAWINGS The following is a brief description of the drawings, which are presented for the purposes of illustrating the exemplary embodiments disclosed herein and not for the purposes of limiting the same.", "FIG.", "1 is an overview diagram of one embodiment of a system for thought-controlled neuromuscular stimulation.", "FIG.", "2 is a block diagram for the decoding and re-encoding architecture operating within the system of FIG.", "1.FIG.", "3 is a flow diagram for one embodiment of a method for providing thought-controlled neuromuscular stimulation.", "FIG.", "4 is a perspective drawing of a neural sleeve according to an exemplary embodiment, shown in place on a human arm.", "FIG.", "5 is a diagram for a concept design for fabricating one embodiment of the neural sleeve.", "FIG.", "6 is a diagram for an etched circuit layer for fabricating one embodiment of the neural sleeve.", "FIG.", "7 is a close-up view diagram of the etched circuit layer of FIG.", "6.FIG.", "8 is an alternative close-up view diagram of the etched circuit layer of FIG.", "6.FIG.", "9 is a diagram for a coverlay layer used in fabricating one embodiment of the neural sleeve.", "FIG.", "10 is a diagram for a silkscreen layer used in fabricating one embodiment of the neural sleeve.", "FIG.", "11 is a stack-up diagram used in fabricating one embodiment of the neural sleeve.", "FIG.", "12 is a flow diagram for one embodiment of a method for producing a neural sleeve.", "FIG.", "13 is an exemplary photograph showing individual finger movement within a system for thought-controlled neuromuscular stimulation.", "FIG.", "14 is an exemplary photograph showing two neural sleeve devices according to one embodiment disposed on a preparation bench.", "FIG.", "15 is an exemplary photograph showing two neural sleeve devices according to the embodiment of FIG.", "14.FIG.", "16 is an exemplary photograph showing two neural sleeve devices according to a different embodiment.", "FIG.", "17 is an exemplary photograph showing a rigidizer and the primary side of a neural sleeve device according to yet another embodiment.", "FIG.", "18 is an exemplary photograph showing the positioning of a patient's arm region over two neural sleeve devices according to the embodiment of FIG.", "14.FIG.", "19 is an exemplary photograph showing two neural sleeve devices according to the embodiment of FIG.", "14 which are wrapped around a patient's arm region in preparation for neuromuscular stimulation.", "FIG.", "20 is an exemplary photograph showing two neural sleeve devices according to the embodiment of FIG.", "14 which are alternatively wrapped around a patient's arm region in preparation for neuromuscular stimulation.", "FIG.", "21 is diagram of another exemplary embodiment of a neural sleeve.", "In this embodiment, conductive pathways extend from two different connectors.", "The fingers extend in the same direction, and taper towards a center axis.", "FIG.", "22 is an exemplary illustration of a fingerless neural sleeve in the form of a glove that can reach up to the elbow.", "FIG.", "23 is an exemplary illustration of a variation of the neural sleeve of FIG.", "22, in which the neural sleeve includes a user interface on the exterior in the form of buttons.", "FIG.", "24 is an exemplary illustration of a neural sleeve made of a flexible material with electrodes on the interior and implants for providing directionality to the neural sleeve.", "FIG.", "25 is an exemplary illustration of a neural sleeve in the form of a rigid shell having two hemicylindrical halves joined together by a hinge along the sidewall.", "FIG.", "26 is a cross-sectional illustration of a resuable neural sleeve, which is in the form of a flat flexible sheet that can be wrapped around the arm.", "FIG.", "27 is an exemplary illustration of a neural sleeve with expandable bladders for pushing the electrodes against the skin.", "A handle can be included with the sleeve for proper registration/orientation of the neural sleeve.", "FIG.", "28 is an exemplary magnified illustration of the construction of the flexible conductive pathways of the neural sleeve.", "These pathways can include electrodes as well as other components, for example strain gauges.", "FIG.", "29 is an illustrative diagram showing a neural sleeve applied to the arm of a user.", "This particular neural sleeve is in the form of a fingerless glove that covers the palm of the hand, extends past the wrist and the through the elbow up to the shoulder of the user.", "The locations of various sensors are highlighted in this diagram.", "DETAILED DESCRIPTION A more complete understanding of the processes and apparatuses disclosed herein can be obtained by reference to the accompanying drawings.", "These figures are merely schematic representations and are not intended to indicate relative size and dimensions of the assemblies or components thereof.", "Although specific terms are used in the following description for the sake of clarity, these terms are intended to refer only to the particular structure of the embodiments selected for illustration in the drawings, and are not intended to limit the scope of the disclosure.", "In the drawings and the following description below, it is to be understood that like numeric designations refer to components of like function.", "With reference to FIG.", "1 and FIG.", "2, a system for thought-controlled neuromuscular stimulation may include a cortical implant 102 implanted into the cerebral cortex region of the brain.", "The cortical implant 102 in one embodiment includes a microelectrode sensing array, as depicted in FIG.", "1.The microelectrode sensing array includes multiple channels (e.g.", "96 channels) and may be wired to an amplifier which further amplifies signals received by the microelectrode array.", "The cortical implant 102 records “brain waves,” more particularly neural signals which are representative of a varied set of mental activities.", "Neural signals include electrical signals produced by neural activity in the nervous system including action potentials, multi-unit activity, local field potential, ECoG, and EEG.", "These neural signals are sent wirelessly or, alternatively, through a wired connection, from the cortical implant 102 to a receiver on a neural signal processor device 104 for processing of the neural signals.", "In another embodiment, a scalp based interface, headset, or other sensor 102 picks up electroencephalogram (EEG) signals and sends them to the receiver on the neural signal processor device 104.The neural signal processor 104 may include a processor including neural decoding algorithms 106 and/or control algorithms 108.These algorithms 106, 108 allow for a received neural signal input to be decoded and subsequently re-encoded for use in neuromuscular stimulation.", "For example, a received neural signal may be isolated to predict arm and/or hand movements a patient is thinking about.", "The neural signal processor 104 may also include an oscilloscope or other signal waveform viewing and/or manipulation device.", "The neural signal processor also preferably includes an isolated pulse stimulator 111 which receives a processed signal and generates a pulse signal for use in neuromuscular stimulation by an attached neuromuscular stimulation cuff 110.With reference to FIG.", "2, the system for thought control at a more complex architectural level includes the cortical implant or sensor 102 and the neural signal processor 104 which allow for the recording of neural signals and the initial processing of the signals, respectively.", "Initial signal processing may include analog to digital conversion, normalization, and/or other filtering and processing methods known by one having ordinary skill in the art.", "Initially processed signals are then decoded by the neural decoding algorithms 106.In exemplary embodiments, the neural decoding algorithms 106 include force-based algorithms with firing-rate estimators.", "The decoded signal output of the neural decoding algorithms 106 is further processed by the stimulation control algorithms 108.In exemplary embodiments, the stimulation control algorithms 108 produce an output of peak current amplitude modulated, pulse width modulated, or frequency modulated pulse trains going to the cuff electrodes.", "The pulse train can also be a non-stationary Poisson type train where average pulse rate (frequency) is modulated.", "This may help reduce muscle fatigue as it more closely matches to the body's natural nervous system.", "An example of using poisson-distributed impulse trains to characterize neurons in a region of the brain is disclosed in Pienkowski et al., Wiener-Volterra Characterization of Neurons in Primary Auditory Cortex Using Poisson-Distributed Impulse Train Inputs, J. Neurophysiology (March 2009).", "Stimulation control algorithms 108 may be altered through input received from a training profile 107.The training profile 107 may include training profile data representative of past user training sessions, e.g.", "motion demonstrations or coaching periods.", "Training data may be used to alter and/or define simulation control algorithms 108 during signal processing.", "Incorporating training data into stimulation control algorithms 108 through a model-based approach yields more accurate decoding, e.g.", "patient thoughts accurately translated into a complex motion, than prior position-based decoding efforts have shown.", "Additionally or alternatively, wrist-hand position feedback 109 may be used to alter and/or define stimulation control algorithms 108 during signal processing.", "Signal control algorithm 108 output may be sent to the isolated pulse generator 111, where the signal is converted into a waveform that is suitable for neurostimulation.", "Suitable waveforms may include monophasic and biphasic pulses with a voltage between 80 to 300 Volts.", "However, even higher voltages may be used as long as safe current levels are maintained and proper insulation is used.", "In exemplary embodiments, the waveform is a monophasic pulse with a peak current of 0-20 mA which is modulated to vary strength of muscle contraction, frequency of 50 Hz, and a pulse width duration of 500 ms.", "The output of the isolated pulse generator 111 is sent to the neuromuscular stimulation cuff 110 to deliver functional electrostimulation to the patient.", "With reference to the flow diagram set forth in FIG.", "3, a method for providing thought-controlled neuromuscular stimulation S100 starts at S101.At S102 neurological signals are received from a patient indicative of an intended action.", "For example, neurological signals may be received though cortical implant 102.At S104 the neurological signals are processed, which may include analog to digital conversion or filtering.", "At S106, the digitized signals are decoded by at least one neural decoding algorithm 106.At S108, the decoded signals are processed by at least one stimulation control algorithm 108.At S110, the method alternatively includes altering the stimulation control algorithms 108 by training data which is stored in the training profile 107.At S112, the method alternatively includes altering the stimulation control algorithms 108 based on movement data, e.g.", "wrist-hand position feedback 109.At S114, the output of the at least one signal control algorithm 108 is converted into a re-encoded signal consisting of multiple pulse trains, each pulse train going to a corresponding electrode 114.At S114, neuromuscular stimulation is delivered to the patient by sending the re-encoded signal to the neuromuscular stimulation cuff 110.In another embodiment, the method for providing thought-controlled neuromuscular stimulation S100 further includes at S117 delivering neuromuscular stimulation to the patient by selectively delivering stimulation to at least one pair of electrodes 114 within a neuromuscular cuff 110 to effectuate the intended action.", "In yet another embodiment, the method S100 further includes S103 recording neurological signals from a patient.", "These neurological signals may be sensed from, e.g., a forearm or wrist region with neural pathway damage.", "Recording may also occur at a neurologically intact region such as a functional leg, for which stimulation pulses can be provided for stimulating commonly tied motions in damaged limbs, e.g.", "arms and legs.", "Commonly tied motions include hip and arm movements or pivoting movements.", "In the same embodiment, method S100 at S118 may further include delivering neuromuscular stimulation to the patient by selectively stimulating to at least one pair of electrodes within the neuromuscular cuff 110 based on the re-encoded signal.", "With reference to FIG.", "4, an exemplary embodiment of the neuromuscular stimulation cuff 110 includes a flexible printed circuit board (PCB) 112 upon which electrodes 114 and hydrogel discs 116 are arranged in an electrogel disc array 118.The neuromuscular stimulation cuff 110 fits over a damaged or degenerative region 120 of the nervous system, e.g.", "a patient's arm as illustrated.", "The flexible PCB 112 acts as a substrate upon which the electrodes and other conductive materials are laid.", "This flexible base layer may be comprised of a single layer of a flexible insulating material, for example a polyimide material.", "Up to approximately twenty electrodes 114 may be individually etched onto each finger 124 of the flexible PCB 112 as a copper layer.", "In exemplary embodiments, the flexible PCB 112 has a total of eighty electrodes 114 disposed over four fingers 124.The electrodes 114 may be subsequently plated with a conductive metal such as gold, palladium, or silver for greater conductivity.", "In some embodiments, electrodes 114 both stimulate a neuromuscular region 120 by stimulating individual muscles and/or groups of muscles, as well as monitor or record skeletal muscle activity, specifically electromyography (EMG) signals.", "Sensed EMG data pertaining to a sensed muscle target may be used in methods for closed or open loop stimulation of the muscle target.", "Sensed EMG data may also be analyzed in deciding whether to reposition the neuromuscular stimulation cuff 110 within the neuromuscular region 120 or to turn off individual electrodes 114 within the electrogel disc array 118.Hydrogel discs 116 may be rolled over the electrodes 114 to provide enhanced electrical and mechanical coupling.", "When appropriately aligned, the hydrogel discs 116 completely cover the electrodes 114 and effectively form conductive electrogel discs 117.Put another way, the electrodes are located between the base layer and the hydrogel discs.", "Electrical coupling is enhanced in that hydrogel provides greater conductive contact with the skin than is achievable with a bare metal-plated electrode surface.", "Additionally, a carrier signal provided to any of the electrogel discs 117 in the electrogel array 118 may conduct through the tissues of a patient and be released at any other electrogel disc 117 provided in the array 118.Enhanced mechanical coupling is provided through the exemplary adherence characteristics of hydrogel to the skin.", "Hydrogel discs 116 may stay coupled to the skin even during complex patient movement.", "The hydrogel discs are commercially available as a tape which may be rolled on an electrode surface.", "One such example includes AmGel 2550 from AmGel Technologies.", "In the exemplary embodiment of the neuromuscular cuff shown in FIG.", "4, the hydrogel discs are provided through custom spaced hydrogel discs located on AmGel 2550 rolled hydrogel tape.", "In the alternative, instead of hydrogel discs, a lotion or discs of a conductive polymer could be used.", "The electrogel disc array 118 is spread over a plurality of fingers 124, wherein the fingers 124 are cut from the flexible PCB 112 to provide additional flexibility in the placement of electrogel discs 117.Reanimation of complex motion may require stimulating muscles which are not located directly along the dimensions of a conventionally shaped neuromuscular cuff 110.By wrapping fingers 124 around different muscular regions, e.g.", "the lower wrist and thumb, complex motions such as thumb movement may be reanimated more effectively than with limited placement options.", "FIGS.", "5-11 are views of various layers of the neuromuscular stimulation cuff, and are separated for convenience and understanding.", "With reference to FIG.", "5, one embodiment of the neuromuscular stimulation cuff device 110 (or neural sleeve) may be fabricated in accordance with a concept design 500.Dimensions of and between the various components of the concept design 500 are indicated in millimeters (mm).", "The concept design 500 includes, as shown here, an insulating base layer, for example made of a single layer of polyimide base material 522.In some embodiments, the polyimide base material is a DuPont AP8523E polyimide which is 50 μm (micrometers) thick and rolled-annealed copper clad at 18 μm thick.", "This base material serves as a substrate for the other layers of the neuromuscular stimulation cuff.", "This base material is formed, for example by cutting, into at least two flexible fingers.", "As illustrated here, the base material 522 is cut into four fingers 524, where the electrodes will be located or housed.", "The fingers can be attached to each other, for example by five webbings 525 which run between adjacent fingers.", "The fingers 524 extend in the same direction from the rigidizer 530, which acts as a connector for one end of the fingers.", "In other words, the ends of the fingers distal from the rigidizer are all located in the same direction relative to the rigidizer, or put another way the rigidizer 530 is at one end of the device.", "It is noted that the fingers 524 are shown here as extending at a 90-degree angle relative to the connector/rigidizer 530.It is contemplated that the flexible fingers could extend at any angle from the connector 530.Referring back to FIG.", "4, setting the flexible fingers at an angle from the rigidizer would permit the flexible fingers to be wound helically around the arm and down along the entire length of the arm.", "The rigidizer 530 is used for interfacing with the neural signal processor 104.Drilled holes 531 are additionally located on the rigidizer 530 which represent connector pin insertion points.", "In exemplary embodiments, eighty drilled holes 531 are approximately 1.016 mm in diameter with a tolerance of +/−0.05 mm.", "As illustrated here, the fingers 524 are parallel to each other along their entire length.", "As will be seen later, this is not a requirement.", "If desired, an optional fork 526 can be located at the end of the fingers opposite the connector/rigidizer 530.The fork connects all of the fingers, and can be provided for structural support for design and mounting.", "Drilled holes 527 are provided in the fork 526 for support and/or mounting purposes.", "In some embodiments, the four drilled holes 527 are approximately 2.387 mm in diameter with a tolerance of +/0.076 mm.", "Headers 528 extend between the rigidizer and the fingers.", "These headers are thinner than the fingers, and connect the fingers 524 to the rigidizer 530.The headers are also part of the overall flexible finger, though they are not always required.", "Though not illustrated, webbings can also be provided between adjacent headers as well if desired.", "Again, as will be seen later, the fork 526 is optional, though the connector 530 is required.", "With reference to FIG.", "6, a conductive circuit layer 600 for fabricating the neuromuscular stimulation cuff device 110 is shown.", "The conductive circuit layer 600 is located on the surface of the insulating polyimide substrate 622, upon which copper electrodes 640 and connective copper traces 642 are formed to make a conductive pathway, for example by etching, deposition, ablation, etc.", "The electrodes 640 and traces 642 run along the four fingers 624 of the substrate 622.The traces 642 run longitudinally down the four headers 628 to electrically connect the electrodes 642 to the connector/rigidizer 630.Again, the connector/rigidizer 630 is used for interfacing with the neural signal processor 104.The traces 642 continue onto rigidizer 630 and end, in this exemplary embodiment, at eighty connective points 632, which represents twenty connective points 632 per finger 624.Each of the eighty connective points 632 corresponds to an individual electrode 640, electrically connected through an individual trace 642.FIG.", "7 is a closer view of the conductive circuit layer 600 of FIG.", "6.The substrate 622, electrodes 640, and traces 642 are more particularly seen here.", "Each electrode 640 is individually connected to a single trace 642, and the trace 642 runs down header 628 to the connector/rigidizer 630 (not shown).", "In some embodiments, the traces 642 are approximately 0.127 mm in width.", "As illustrated here, each electrode 640 includes at least one ear 641 which is used to support the electrode 640 upon the insulating substrate 622.As seen here, each electrode includes a central area 643 and three ears 641.The central area has a circular shape, and is used as an electrical contact.", "Each ear extends beyond the perimeter of the central area.", "As illustrated here, two ears are separated by 60 degrees, and are separated from the third ear by 150 degrees.", "Referring to FIG.", "8, the conductive circuit layer illustrated in FIG.", "6 may include electrodes 640 that are approximately 12 mm in diameter (not counting the ear) and spaced 15 mm apart.", "This 15 mm spacing between electrodes would dictate the custom spacing required for subsequent application of hydrogel discs 114.FIG.", "9 illustrates an insulating cover or “coverlay” layer 700 which would be placed over the electrodes and traces.", "The coverlay layer can be made from a single layer of an insulating material such as polyimide 722, which is preferably thinner than the substrate upon which the electrodes and traces are copper-etched or otherwise formed.", "In one embodiment, the coverlay layer is a DuPont LF0110 polyimide material which is a 25 μm thick coverfilm.", "A further thickness of 25 μm of acrylic adhesive can be used for adhering the coverlay layer 700 to the conductive circuit layer 600.The coverlay layer also includes a fork 726, fingers 724, headers 728, and rigidizer section 730 which corresponds to these areas on the base substrate 522 and the conductive circuit layer 600.Cutouts 740 are left in the fingers to expose the central area of the electrodes, and on the rigidizer section 730 for the electrical connectors.", "The insulating cover layer 700, when applied over the conductive circuit layer 600, covers the copper traces 642 formed on the fingers 724 and the headers 728.The coverlay layer 700 does not cover the central area 643 of the electrodes, but does cover the ears 641, thus fixing the electrodes in place between the substrate and the coverlay layer.", "In addition, the electrical connectors in the rigidizer section 730 will remain uncovered.", "The exposed central areas of the electrodes 640 are preferably plated with a conductive metal such as tin, platinum, or gold.", "In one embodiment, exposed copper electrodes are plated with electroless-nickel-immersion-gold (ENIG) at the level of 3-8 μm gold over 100-150 μm nickel.", "FIG.", "10 is a diagram for a silkscreen layer 800 that can be used in fabricating the neuromuscular stimulation cuff device 110.The silkscreen layer 800 is applied to the combination of the conductive circuit layer 600 and coverlay layer 700 to identify individual electronic elements.", "A first silkscreen identification number 850 is provided to each electrode 840 so that it may be more easily found after visual inspection.", "In one embodiment, first silkscreen identification numbers 850 span from A1-A20 and D1-D20 to represent eighty individual electrodes 840.A second silkscreen identification number 852 identifies the connection ports for a rigidizer 830.In one embodiment, second silkscreen identification numbers 852 span from J1-J4.Both first and second silkscreen identification numbers 850, 852 are provided on a secondary side of the neuromuscular stimulation cuff 110, or side facing away from exposed electrodes 740.In an exemplary embodiment, silkscreen identification numbers 850, 852 are provided by white epoxy nonconductive ink.", "Referring now to FIG.", "11, various embodiments of the neuromuscular stimulation cuff device may be fabricated according to stack-up diagram 900.An insulating base material (e.g.", "polyimide) provides a substrate 950 upon which various components are fixed.", "A secondary side rigidizer 830 is laminated to a secondary surface of the substrate 950.The conductive circuit layer 600 is fabricated onto a primary surface of the substrate (opposite the secondary surface), and includes electrodes and traces that form conductive pathways on the flexible base substrate.", "The coverlay layer 700 is subsequently adhered to the conductive circuit layer 600 which covers the traces and leaves exposed portions of the electrodes.", "The combination of the substrate 950, conductive circuit layer 600, and coverlay layer 700 is defined as the flexible finger 912.Primary rigidizer 730 is stacked upon the coverlay layer to complete the electrical connection required to interface the flexible finger with the neural signal processor 104.With reference to the flow diagram set forth in FIG.", "12, one embodiment of a method for producing a neuromuscular cuff S200 starts at S201.At S202 a single layer of polyimide base material 950 is provided.", "At S204, a conductive circuit layer is fabricated onto the polyimide base material 950 by etching a conductive copper circuit into the polyimide.", "At S206 a polyimide coverlay layer 700 is adhered to the conductive circuit layer 600.Adhering the coverlay layer 700 to the conductive circuit layer 600 completes the formation of a flexible PCB from which the flexible conductive pathways 912 will be formed.", "At S208, a plurality of flexible fingers are formed from the flexible PCB to provide additional contact points for stimulation of muscles or sensing EMG signals.", "At S210, finger webbings 725 may optionally be cut from the flexible PCB to separate the flexible fingers and provide additional flexibility, such as to accommodate limb twisting (such as the forearm) while maintaining contact.", "At S212, hydrogel may optionally be rolled over the electrodes to create electrogel discs 117.At S214, a rigidizer 630, 730, 830 is attached to the flexible fingers 912 for interfacing with the neural signal processor 104.At S216, the flexible fingers 912 are interfaced with the neural signal processor 104.With reference to FIG.", "13, individual finger movement within a system for thought-controlled neuromuscular stimulation 1000 is demonstrated.", "A neuromuscular cuff 1010 according to one embodiment is wrapped over a damaged or degenerative region 1020 of the nervous system.", "The neuromuscular cuff 1010 is interfaced with a neurological signal processor 1004 through attached rigidizer 1030.The rigidizer is attached to a connection port 1005 on the neural signal processor 1004.Received neurological signals indicative of patient thinking about moving their first two digits has been decoded and re-encoded into pulse train signals transmitted to various electrodes on the neuromuscular stimulation cuff 1010.Using a specific number and spacing of electrodes/electrogel discs 1017 in neuromuscular stimulation cuff 1010 has allowed for high resolution and non-invasive neuromuscular stimulation which effectuates the intention of the patient.", "Electrogel discs 1017 operate in pairs when reanimating motion.", "Individual digit movement may be effectuated through the operation of two to three pairs (4 to 6 units) of electrogel discs 1017 which are stimulating in tandem.", "Selecting particular pairs of electrogel discs 1017 to reanimate motion as indicated by a decoded brain signal is advantageously performed by the neuromuscular stimulation cuff 1010, as each electrogel disc 1017 is connected to the neurological signal processor 1004 individually along a single traces etched into a conductive layer of flexible polyimide material.", "With reference to FIG.", "14, two neuromuscular cuff devices 1010 according to one embodiment are disposed on a preparation bench 1070.The preparation bench 1070 may be used to keep cuff devices 1010 flat and roll hydrogel tape across electrodes 1016.Properly adhered hydrogel discs 116 (not shown) should fully cover the surface of electrodes 1014.With reference to FIG.", "15, two neuromuscular cuff devices 1010 according to the embodiment of FIG.", "14 are shown.", "The cuff devices 1010 each include a fork 1026 for additional support when designing and/or placing the cuff devices 1010 over a damaged or degenerative region/pathway of the nervous system (not shown).", "Again, the fork is optional.", "With reference to FIG.", "16, two neuromuscular cuff devices 1110 according to a different embodiment are shown.", "A fork 1126 is provided at one end of each cuff for additional design and/or structural support, similar to the fork 626 in FIG.", "6.Here, a second fork 1127 is also provided located along the headers 1128.Put another way, the flexible fingers 1124 are bracketed by a fork on each end.", "The additional fork 1127 provides additional support in combination with fork 1126 for situations when the neuromuscular cuff 1110 must be stretched flat across a surface.", "Additional fork 1127 can also maintains flexible fingers 1124 within the same damaged or degenerative region/pathway 1120 (not shown), which effectively concentrates stimulation and prevents flexibility.", "With reference to FIG.", "17, the primary side of another embodiment of the neuromuscular cuff 1200 is shown.", "Hydrogel discs 1216 have been applied to electrodes 1214 (not shown, covered), forming an electrogel disc array 1218.Two of the four flexible fingers 1224 still include the hydrogel tape before being separated from hydrogel discs 1216.Electrogel discs 1217 are not connected to each other within the array 1218 so that the electrogel discs 1217 may be independently stimulated.", "While not exposed to the air, copper traces 1242 are viewable through the polyimide cover layer 700.A secondary side rigidizer 1230 is shown by folding the primary side over at the headers 1228.Connectors 1234 on the secondary side rigidizer 1230 allow for the neuromuscular stimulation cuff 1200 to be interfaced with the neural signal processor 104 (not shown).", "Each pin 1236 within connector 1234 is electrically connected with a single electrogel disc 1217.With reference to FIG.", "18, a patient's arm including damaged or degenerative regions/pathways 1020 is placed over two neuromuscular cuff devices 1010 according to the embodiment of FIG.", "14.Flexible headers 1028 may be used as support while positioning the device 1010 under an arm.", "With reference to FIG.", "19, two neuromuscular cuff devices 1010 in an exemplary embodiment are wrapped around a patient's arm region 1020 in preparation for neuromuscular stimulation.", "The two cuff devices 1010 together provide 160 separate electrodes for stimulating finger or wrist movements.", "The flexible fingers 1024 permit the neuromuscular cuff to fit around the arm region 1020 at points of varying circumference.", "Hydrogel discs 1016 (not shown) keep both cuffs 1010 adhered to the arm.", "With reference to FIG.", "20, two neuromuscular cuff devices 1010 according to the embodiment of FIG.", "14 are alternatively wrapped around a patient's arm region in preparation for neuromuscular stimulation.", "Only two flexible fingers 1024 of one of the neuromuscular cuff devices 1010 have been applied, while all of the flexible fingers 1024 on the other cuff device 1010 are already wrapped around the patient's arm.", "More or less electrodes can be used, as shown in FIG.", "20, depending on the nature of the damage to a patent's nervous system region/pathway 1020 and the type of movement one wishes to reanimate through neuromuscular stimulation.", "In another exemplary embodiment, the flexible fingers of a neural sleeve 2110 do not need to be straight for their entire length.", "Referring now to FIG.", "21, flexible fingers 2124 extend from first connector 2130, which has a rectangular shape in this illustration.", "The flexible conductive pathways 2124 in this embodiment “change” directions as they extend from connector 2130.For example, an upper flexible finger 2124a first extends upwards from the connector 2130, then changes direction so that its electrodes 2140 are to the right of the connector 2130.A center flexible finger 2124b extends from the right-hand side of the connector 2130 off to the right of the connector.", "A lower flexible finger 2124c first extends downwards from the connector 2130, then changes direction so that its electrodes 2140 are also to the right of the connector 2130.Notably, none of the electrodes 2140 are present to the left of the connector 2130.This embodiment of a neural sleeve 2110 also contains more than one connector/rigidizer.", "As illustrated here, the neural sleeve 2110 has a first connector 2130 and a second connector 2131.Flexible fingers extend in the same direction (here, to the right) of both connectors.", "Webbings 2135 connect flexible fingers extending from each connector 2130, 2131.There may be any number of webbings 2135, and the webbings 2135 may connect the flexible fingers at any portion of their length.", "Here, the webbings 2135 are present along a non-electrode-containing portion 2150 of the flexible fingers (i.e.", "the header portion).", "Though not depicted, it is specifically contemplated that the flexible fingers of one connector 2130 may be of a different length from the flexible fingers of the other connector 2131.The electrodes 2140 may be evenly spaced apart along the length of the flexible fingers 2124, or their spacing may vary, for example becoming shorter or longer, as the distance from the connector 2130 increases.", "For example, muscle segments get smaller closer to the wrist, so the electrodes need to be closer together as well.", "However, the electrodes do not need to be present along the entire length of the flexible fingers.", "As seen here, the flexible fingers 2124 may include a non-electrode-containing portion 2150 extending from the connector, which is similar to the header 528 of the embodiment of FIG.", "5.The flexible finger may also include a non-scalloped electrode-containing portion 2160, and a scalloped electrode-containing portion 2170 at the distal end of the flexible finger (i.e.", "distal from the connector).", "It should be noted that none of the flexible fingers overlap with each other.", "The electrode-containing portions 2160, 2170 of the flexible fingers have a different shape from each other.", "One reason for this difference in shape is because, as seen here, the distal ends of the flexible fingers 2124 extend inwardly towards a center axis 2105 of the neural sleeve 2110.Put another way, the flexible fingers 2124 taper inwards towards the center axis 2105.The scalloped portions 2170 of adjacent flexible fingers permit them to fit into a smaller area while still providing a suitable number of electrodes (note the electrodes do not change in size).", "However, the flexible fingers 2124 all still extend in the same direction away from the connector 2130, i.e.", "to the right in this figure.", "Put another way, the flexible fingers comprise a first portion which is transverse to the center axis 2105, and a second portion which is parallel to the center axis.", "These portions are particularly seen in the flexible finger 2124a, which first extends upwards (i.e.", "transversely to the center axis), then extends parallel to the center axis.", "This particular embodiment is intended to be used on a patient's arm with the two connectors 2130, 2131 located near the shoulder, and the scalloped portions 2170 near the wrist and hand.", "In other exemplary embodiments, it is contemplated that the neural sleeve will include both an outer, reusable component, and an inner, disposable component.", "Advantageously, this allows for a reduced per-use cost for the outer component, while permitting multiple different persons to use the outer component without hygienic concerns.", "The outer reusable sleeve contains the electrodes.", "It is contemplated that the outer sleeve/reusable component, in several embodiments, could be made of a flexible, stretchy, and/or compressible fabric material which would fit snugly against the user's arm.", "The material could also be a dry-fit material, i.e.", "a material which can move sweat away from the user's arm and permit the sweat to evaporate.", "The connector and flexible fingers would line the interior of the outer sleeve.", "For example, conductive threads or fibers could be woven into the fabric material.", "Alternatively, the conductive traces and electrodes could be printed onto the outer sleeve material using silk-screen technology, for example using conductive polycellulose, a silver-based ink, or carbon-based ink.", "FIG.", "22 and FIG.", "23 show one exemplary embodiment of this neural sleeve.", "FIG.", "22 is an illustration of a neural sleeve 2210 which is in the form of a fingerless glove.", "Not visible in FIG.", "22 is an inner sleeve containing a conductive medium.", "FIG.", "23 is an illustration of a variation on the neuosleeve outer component.", "As illustrated here, the neural sleeve 2310 has a user interface on the exterior reusable component, which can be used for control (including registration, activation, configuration and so forth) of individual electrodes or groups of electrodes, allowing a user to configure the electrodes or adjust a stimulation level or pattern.", "For example, the outer component may include buttons 2311 (e.g.", "in the form of LED-based touchscreens).", "While only four buttons are illustrated here, the user interface can include any number of buttons, and those buttons can be of any shape.", "Another aspect of the present disclosure is illustrated in FIG.", "24.The neural sleeve itself may be made in a bidirectional manner, i.e.", "both ends of the sleeve are of the same construction.", "It is contemplated that directional implants 2402, 2404 could be used to provide directional information to the neural sleeve 2410, e.g.", "which end of the neural sleeve is closer to the elbow or the wrist.", "These implants may be located in the patient's limb, or located at opposite ends of the neural sleeve itself.", "Only one such implant is needed to identify the orientation/direction of the neural sleeve.", "It is noted that three-dimensional information can also be provided by such implants.", "Also depicted are the electrodes 2420.FIG.", "25 is another embodiment of the reusable outer component.", "Here, the outer component is in the form of a rigid shell 2510.The shell is separated into two hemicylindrical halves 2512, 2514 which are joined together by a hinge 2511.The hinge runs parallel to the longitudinal axis 2505 of the shell.", "A closing mechanism 2516 is located on opposite open ends of the halves for keeping the shell closed once it is closed around the user's limb.", "Within the shell is padding for conforming the shell to the user's limb, or a bladder that can be inflated with air.", "The shell houses the electrodes 2520 (which are used for both sensing and delivering neuromuscular stimulation), as well as other accompanying electronics.", "It is contemplated that the disposable inner component (not shown) is first applied to the inside of the shell, or reusable dry electrodes are attached to the inside of the shell.", "Then the limb is placed in the shell, the shell closes around the limb, and the soft padding conforms around the limb and applies pressure on the electrodes against the limb, or the air bladder is inflated to apply pressure to the electrodes against the limb.", "Alternatively, as seen in the cross-sectional view of FIG.", "26, the neural sleeve can be in the form of a flexible sheet 2610 which is wrapped around the user's limb 2601.The electrodes (not visible) are spaced throughout the flexible sheet, and a closing mechanism 2605 is present on opposite ends of the sheet.", "Such a mechanism may be, for example, a hook-and-loop fastener.", "FIG.", "27 illustrates another potential embodiment of the neural sleeve.", "Desirably, the electrodes are fitted snugly against the patient's limb.", "In this embodiment, the neural sleeve 2710 contains bladders 2720 that can be filled with air or some fluid, causing the neural sleeve to expand and push the electrodes 2730 against the limb.", "A pneumatic pump can be used to fill the bladders.", "A directional implant 2702 is also present here at a distal end 2704 of the sleeve.", "In addition, a handle 2740 is also present at the distal end of the sleeve.", "This handle is intended to help with registration of the electrodes in known positions, and also provides directionality to the neural sleeve.", "The neural sleeve can incorporate several different types of sensors to provide information on data and feedback on the position and movements of the limb and other body parts.", "For example, desired position information from the sensors can include a 3-dimensional location (X, Y, Z coordinates) of various points on the hand and arm relative to the body and to each other, and rotation information of the wrist, elbow, and shoulder relative to the body.", "Orientation of various body parts with respect to gravity can also be measured with an accelerometer (or inclinometer).", "Motions of the hand and arm may be derived from position sensors or from independent sensors.", "Other desired information includes joint angles at the elbow, wrist, thumb and fingers (or other body joints).", "A variety of concepts for sensors may be used to measure one or more of these data items.", "Broad categories of sensors include accelerometers, micro-electro-mechanical (MEMS), electronic (based on resistance, capacitance, or resonance), fluid bladders, optical fiber bend sensors, and video tracking systems.", "Again, these concepts can be generally applied to a neural sleeve on any body part or limb (e.g.", "arm, hand, leg, foot, etc.).", "FIG.", "28 illustrates some aspects which can be used for sensing.", "This is a magnified picture of a flexible conductive pathway 2810.Electrodes 2820 are present on the flexible conductive pathway.", "Here, four electrodes 2820, 2822, 2824, 2826 are illustrated.", "Electrode traces 2830 are present between the electrodes.", "As seen here, the trace have a zig-zag pattern, which can be used as a strain gauge.", "In a first sensor aspect, integrated 6-axis MEMS (3-axis accelerometer and 3-axis magnetometer) sensors can be used to measure the position and orientation of the elbow and wrist relative to the location of the shoulder (e.g.", "the top of the humerus bone).", "When combined, these sensors can provide a reference frame utilizing the Earth's local gravitational (center of Earth) and magnetic (magnetic north) fields.", "Using this reference frame in conjunction with a defined 3-axis Cartesian coordinate system, different joints can be located in both position (X, Y, Z) and orientation (Ψ (yaw), θ (pitch), φ (roll)) relative to the origin of the Cartesian coordinate system at the shoulder using these same MEMS sensors.", "Adjacent MEMS sensors can be placed at strategic locations where the length between sensors does not change (or the change is a sufficiently small amount) when the joints are bent or rotated.", "For example, sensors can be placed at locations on the shoulder, elbow, and wrist where the distance between adjacent sensors remains fixed due to fixed bone lengths.", "The calculation of position and orientation of each joint may use the 3-axis Cartesian coordinate system and reference frame, the fixed distance between adjacent sensors, and the 3-axis output signals from the accelerometers or magnetometers.", "Calculations may involve direction cosine matrices, Euler transformations, or matrix multiplication.", "For sensors that are not adjacent to the origin, their coordinates may be transformed back to the coordinate system origin through intermediate transformations between adjacent sensors.", "For example, if there are sensors at the shoulder, elbow, and wrist then the elbow coordinates can be calculated directly relative to the origin (shoulder), but the wrist coordinates must first be calculated relative to the elbow coordinates and then calculated again relative to the origin.", "The reason for this is because the path lengths must be known for each sensor location and the only way to do this is by coordinate transformations along fixed length paths (e.g., wrist to elbow and elbow to shoulder).", "A wide range of MEMS sensors with integrated 3-axis accelerometers and magnetometers may be used.", "Examples of manufacturers of these devices include Analog Devices, Bosch, Freescale, Honeywell, and ST Microelectronics.", "Also, 9-axis sensors available with integrated 3-axis, accelerometers, magnetomers, and gyros may be used.", "Additional solutions may exist for joint locations where a fixed bone length cannot be counted on such as the hand and fingers.", "In a second sensor aspect, a capacitive sensor may comprise a flexible insulating dielectric layer with thin flexible electrodes on either side.", "A voltage differential is applied between the electrodes, creating a capacitor.", "When the dielectric changes shape (e.g.", "due to pressure or bending), the capacitance of the sensor changes and can be detected by electronic measuring techniques.", "Capacitive pressure sensors may be used in a variety of mechanical systems to measure barometric pressure or pressures inside equipment.", "Such sensors may be incorporated into the sleeve at joints (e.g.", "wrist, elbow) such that bending of the joint stretches or bends the dielectric layer.", "The sensors may also be applied away from joints (e.g.", "middle of the forearm) to measure the pressure of the sleeve against the arm.", "In a third sensor aspect, resistive bend or stretch sensors (e.g.", "strain gauges) may be used.", "These sensors may be made from any material that changes electrical resistance when stretched or strained.", "This change in resistance is measured with a standard electrical circuit.", "Strain gauges may use metal, either alone or applied to a flexible thin film substrate.", "Resistive bend sensors or strain gauges also can be made from the following three general classes of materials.", "First, elastomers (such as silicone rubber) or polymers containing electrically conductive fillers may be used.", "Fillers can include carbon black, graphite, graphene, carbon nanotubes, silver nanoparticles, silver nanowires.", "Second, inherently conductive polymers may be used.", "Third, piezoelectric polymers may be used.", "Resistive sensors may also be applied at joints.", "Bending of the joint will stretch the sensor, causing a measurable change in resistance.", "Pronation and supination of the wrist can be measured by using sensors in the form of long elastic bands that stretch at an angle from the wrist to the elbow.", "Each motion (e.g.", "pronation and supination) will create opposite effects in the bands, causing one to lengthen and the other to shorten.", "In a fourth sensor aspect, resonant bend sensors may be used.", "Resonant bend sensors comprise RLC circuits that change resonance frequency when one of the three components changes its value.", "Rather than having a separate circuit to measure the resistance of each resistive sensor element, the resistive sensors may be wired in parallel at appropriate locations in the neural sleeve.", "Each sensor may have a different resistance to produce a different resonant frequency in the circuit.", "A sweep of voltage or current may be used to test each sensor in rapid succession; this measures changes in resonant frequency to determine changes in resistance and thus in strain of that specific sensor.", "In a fifth sensor aspect, a sensor may comprise numerous trapped volumes (e.g.", "fluid bladders) containing air or liquid that respond to changes in motion.", "For each motion to be detected, a fluid bladder of a specifically designed shape would be placed at an appropriate location such that the pressure in the bladder would change only in response to that motion.", "For example, there may be one bladder at the wrist in a position and shape to detect wrist flexion, while a different bladder at the wrist detects pronation.", "Sensing elements, such as pressure transducers or strain gauges, would respond to the pressure changes.", "In a sixth sensor aspect, bend sensors also can be made from fiber optics rather than electrical components.", "The principle is similar to the electronic bend sensors in that when the fiber is bent, a measurable property such as frequency or attenuation changes and this change can be measured.", "The usage would be similar to the bend sensors described above, with fiber optic bend sensors integrated into the sleeve at joints such as the wrist, such that the sensor bends with bending of the joint.", "In a seventh sensor aspect, a variety of video motion tracking systems may be used to measure and track the position of the limb while using the neural sleeve.", "These systems are similar to the ones used for motion capture in movies and video games.", "One or more cameras may focus on the sleeve during use.", "To provide the best accuracy, these systems would include markers at key locations on the sleeve to be tracked.", "Depending on the type of marker selected, the camera may operate in visible light or infrared.", "A number of options are available for markers, including: (i) dots in a contrasting color or multiple distinct colors that can be tracked by the external camera(s) (similar to typical movie motion capture); (ii) colored light emitting diodes (LEDs); (iii) Infrared (IR) LEDs at various frequencies in the near-IR range; and (iv) thermal elements such as electrically resistive heaters that create localized warm spots to be tracked by a camera sensitive to long wavelength infrared (LWIR).", "FIG.", "29 is a perspective illustration of a neural sleeve 2910 showing how various sensors could be placed thereon and implemented.", "The neural sleeve extends from the shoulder down to the wrist.", "First, a trio of MEMS sensors 2920, 2922, 2924 are located at the shoulder, elbow, and wrist, respectively.", "These can be used to measure position and orientation relative to each other.", "Next, a capacitive sensor 2930 is located at the elbow.", "Resistive bend sensors 2940, 2942 stretch at an angle from the wrist to the elbow.", "Motion will create opposite effects in these sensors, causing one to lengthen and the other to shorten.", "As discussed above, it is contemplated that the neural sleeve will be made of a reusable outer component and an inner component that can be easily disposed of.", "The inner component comprises a conductive medium that contacts the electrodes present in the outer component and provides a conductive interface/medium between the electrode and the user's skin.", "In particular embodiments, the conductive medium can be a hydrogel, or a lotion, or a conductive polymer.", "In some embodiments, the conductive medium is more conductive in a z-direction and less conductive in either of a x-direction or a y-direction.", "Put another way, the conductive medium may become more conductive upon application of external pressure, in the direction of external pressure.", "This property can be obtained from a compressible polymer and a conductive filler dispersed in the compressible polymer.", "The conductive filler can be in the form of carbon fibers, carbon nanotubes, or metallic particles such as silver, gold, platinum, or palladium.", "The conductive filler is sparsely distributed in the polymer so that when pressure is applied, the conductive fillers make contact with each other and provide a conductive path from the electrode to the skin.", "Other conductive hydrogels include a cross-linked alginate polymer or a cross-linked polymeric hydrogel.", "In alternative embodiments, to facilitate attachment to a patient, the conductive medium may be selected such that it becomes more tacky or sticky upon application of an electrical current, a change in temperature, a change in pH, or a change in moisture.", "The conductive medium may be a stimuli-sensitive polymer.", "To further facilitate attachment and/or delivery of electrical simulation, the electrodes may include concentric rows of teeth about 200 μm to about 300 μm in height.", "If desired, the neural sleeve may be configured for gesture control of various devices.", "Examples of devices that may be controlled are: a computer cursor; an automatic remote; and a haptic interface.", "The gesture control aspects are also used in virtual reality applications.", "Gesture control is facilitated by the addition of sensors on the neuromuscular stimulation device/neural sleeve.", "It is noted that the electrodes present in the neural sleeve for stimulation can also be used for sensing.", "In another aspect, a neural sleeve device is used to support gait-training.", "To facilitate this, the neural sleeve would be adapted to cover both a leg portion and a foot portion of the patient.", "This allows the neural sleeve to cover both the muscles and the joint of a patient, and advantageously allows for sensing of a foot flexing.", "A hip portion may also be covered; this allows for stimulation of additional areas to promote recovery following surgery.", "In yet another aspect, neuromuscular stimulation may be delivered to the backside of the patient.", "To facilitate this, the neuromuscular stimulation device may be in the form of a shirt, vest, garment, belt, or so forth, with the electrodes appropriately placed to contact the backside.", "The neuromuscular sleeve/neural sleeve could be operated in a wireless, battery-operated mode.", "In this case, the battery pack and the electronics module can be strapped on the upper arm of the subject in the form of an arm band.", "The device can be connected to the user's mobile device and/or PC for data transfer and real time tracking/monitoring.", "It will further be appreciated that the disclosed techniques may be embodied as a non-transitory storage medium storing instructions readable and executable by a computer, (microprocessor or microcontroller of an) embedded system, or various combinations thereof.", "The non-transitory storage medium may, for example, comprise a hard disk drive, RAID or the like of a computer; an electronic, magnetic, optical, or other memory of an embedded system, or so forth.", "The present disclosure has been described with reference to exemplary embodiments.", "Obviously, modifications and alterations will occur to others upon reading and understanding the preceding detailed description.", "It is intended that the present disclosure be construed as including all such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof." ] ]
Patent_15872734
[ [ "Mattress", "A foam mattress in which a layer of latex or latex-like foam placed above a layer of memory foam is described.", "This construction of the mattress provides the contouring pressure relief that a visco-elastic foam provides with a top surface with quick recovery (a latex-like “bounce”) that prevents people from getting “stuck” in the visco-elastic foam and improves the springiness of the mattress.", "The mattress may also include straps and cinches to aid in transportation of the mattress.", "The mattress may also include removable covers that aid in keeping the mattress clean." ], [ "1-20.", "(canceled) 21.An apparatus comprising: a mattress, the mattress comprising a first horizontal layer, a second horizontal layer positioned below the first horizontal layer, and a third horizontal layer positioned below the second horizontal layer; wherein the first horizontal layer comprises latex foam; wherein the second horizontal layer comprises memory foam; wherein the third horizontal layer comprises polyurethane foam; and wherein the first horizontal layer has a rebound of at least 40%.", "22.The apparatus as in claim 21, wherein the first horizontal layer has an airflow of at least 2 cubic feet per minute.", "23.The apparatus as in claim 21, wherein the first horizontal layer has a support factor of at least 2.24.The apparatus as in claim 21, wherein the first horizontal layer has a 25% IFD of between 6 to 18 pounds.", "25.The apparatus as in claim 21, wherein the first horizontal layer has a density of between 2 to 4 pounds per cubic foot.", "26.The apparatus as in claim 21, wherein the first horizontal layer has an airflow of at least 2 cubic feet per minute; and wherein the first horizontal layer has a support factor of at least 2.27.The apparatus as in claim 21, wherein the first horizontal layer has an airflow of at least 2 cubic feet per minute; and wherein the first horizontal layer has a 25% IFD of between 6 to 18 pounds.", "28.The apparatus as in claim 21, wherein the first horizontal layer has an airflow of at least 2 cubic feet per minute; and wherein the first horizontal layer has a density of between 2 to 4 pounds per cubic foot.", "29.The apparatus as in claim 21, wherein the first horizontal layer has a support factor of at least 2; and wherein the first horizontal layer has a 25% IFD of between 6 to 18 pounds.", "30.The apparatus as in claim 21, wherein the first horizontal layer has a support factor of at least 2; and wherein the first horizontal layer has a density of between 2 to 4 pounds per cubic foot.", "31.The apparatus as in claim 21, wherein the first horizontal layer has a 25% IFD of between 6 to 18 pounds; and wherein the first horizontal layer has a density of between 2 to 4 pounds per cubic foot.", "32.The apparatus as in claim 21, wherein the first horizontal layer has an airflow of at least 2 cubic feet per minute; wherein the first horizontal layer has a support factor of at least 2; and wherein the first horizontal layer has a 25% IFD of between 6 to 18 pounds.", "33.The apparatus as in claim 21, wherein the first horizontal layer has an airflow of at least 2 cubic feet per minute; wherein the first horizontal layer has a support factor of at least 2; and wherein the first horizontal layer has a density of between 2 to 4 pounds per cubic foot.", "34.The apparatus as in claim 21, wherein the first horizontal layer has an airflow of at least 2 cubic feet per minute; wherein the first horizontal layer has a 25% IFD of between 6 to 18 pounds; and wherein the first horizontal layer has a density of between 2 to 4 pounds per cubic foot.", "35.The apparatus as in claim 21, wherein the first horizontal layer has a support factor of at least 2; wherein the first horizontal layer has a 25% IFD of between 6 to 18 pounds; and wherein the first horizontal layer has a density of between 2 to 4 pounds per cubic foot.", "36.The apparatus as in claim 21, wherein the first horizontal layer has an airflow of at least 2 cubic feet per minute; wherein the first horizontal layer has a support factor of at least 2; wherein the first horizontal layer has a 25% IFD of between 6 to 18 pounds; and wherein the first horizontal layer has a density of between 2 to 4 pounds per cubic foot.", "37.An apparatus comprising: a mattress, the mattress comprising a first horizontal layer, a second horizontal layer positioned below the first horizontal layer, and a third horizontal layer positioned below the second horizontal layer; wherein the first horizontal layer comprises latex foam; wherein the second horizontal layer comprises memory foam; wherein the third horizontal layer comprises polyurethane foam; and wherein the first horizontal layer has an airflow of at least 2 cubic feet per minute.", "38.The apparatus as in claim 37, wherein the first horizontal layer has a support factor of at least 2.39.The apparatus as in claim 37, wherein the first horizontal layer has a 25% IFD of between 6 to 18 pounds.", "40.The apparatus as in claim 37, wherein the first horizontal layer has a density of between 2 to 4 pounds per cubic foot.", "41.The apparatus as in claim 37, wherein the first horizontal layer has a support factor of at least 2; and wherein the first horizontal layer has a 25% IFD of between 6 to 18 pounds.", "42.The apparatus as in claim 37, wherein the first horizontal layer has a support factor of at least 2; and wherein the first horizontal layer has a density of between 2 to 4 pounds per cubic foot.", "43.The apparatus as in claim 37, wherein the first horizontal layer has a 25% IFD of between 6 to 18 pounds; and wherein the first horizontal layer has a density of between 2 to 4 pounds per cubic foot.", "44.The apparatus as in claim 37, wherein the first horizontal layer has a support factor of at least 2; wherein the first horizontal layer has a 25% IFD of between 6 to 18 pounds; and wherein the first horizontal layer has a density of between 2 to 4 pounds per cubic foot.", "45.An apparatus comprising: a mattress, the mattress comprising a first horizontal layer, a second horizontal layer positioned below the first horizontal layer, and a third horizontal layer positioned below the second horizontal layer; wherein the first horizontal layer comprises latex foam; wherein the second horizontal layer comprises memory foam; wherein the third horizontal layer comprises polyurethane foam; and wherein the first horizontal layer has a support factor of at least 2.46.The apparatus as in claim 45, wherein the first horizontal layer has a 25% IFD of between 6 to 18 pounds.", "47.The apparatus as in claim 45, wherein the first horizontal layer has a density of between 2 to 4 pounds per cubic foot.", "48.The apparatus as in claim 45, wherein the first horizontal layer has a 25% IFD of between 6 to 18 pounds; and wherein the first horizontal layer has a density of between 2 to 4 pounds per cubic foot.", "49.An apparatus comprising: a mattress, the mattress comprising a first horizontal layer, a second horizontal layer positioned below the first horizontal layer, and a third horizontal layer positioned below the second horizontal layer; wherein the first horizontal layer comprises latex foam; wherein the second horizontal layer comprises memory foam; wherein the third horizontal layer comprises polyurethane foam; and wherein the first horizontal layer has a 25% IFD of between 6 to 18 pounds.", "50.The apparatus as in claim 49, wherein the first horizontal layer has a density of between 2 to 4 pounds per cubic foot.", "51.An apparatus comprising: a mattress, the mattress comprising a first horizontal layer, a second horizontal layer positioned below the first horizontal layer, and a third horizontal layer positioned below the second horizontal layer; wherein the first horizontal layer comprises latex foam; wherein the second horizontal layer comprises memory foam; wherein the third horizontal layer comprises polyurethane foam; and wherein the first horizontal layer has a density of between 2 to 4 pounds per cubic foot.", "52.An apparatus comprising: a mattress, the mattress comprising a first horizontal layer, a second horizontal layer positioned below the first horizontal layer, and a third horizontal layer positioned below the second horizontal layer; wherein the first horizontal layer comprises latex foam; wherein the second horizontal layer comprises memory foam; wherein the third horizontal layer comprises polyurethane foam; and wherein the second horizontal layer has a recovery of at least 1 second.", "53.The apparatus as in claim 52, wherein the second horizontal layer has an airflow of at least 1 cubic feet per minute.", "54.The apparatus as in claim 52, wherein the second horizontal layer has a support factor of less than 2.6.55.The apparatus as in claim 52, wherein the second horizontal layer has a glass transition temperature of between 40 to 80 degrees Fahrenheit.", "56.An apparatus comprising: a mattress, the mattress comprising a first horizontal layer, a second horizontal layer positioned below the first horizontal layer, and a third horizontal layer positioned below the second horizontal layer; wherein the first horizontal layer comprises latex foam; wherein the second horizontal layer comprises memory foam; wherein the third horizontal layer comprises polyurethane foam; and wherein the second horizontal layer has a 25% IFD of between 6 and 18 pounds.", "57.The apparatus as in claim 56, wherein the second horizontal layer has an airflow of at least 1 cubic feet per minute.", "58.The apparatus as in claim 56, wherein the second horizontal layer has a support factor of less than 2.6.59.The apparatus as in claim 56, wherein the second horizontal layer has a glass transition temperature of between 40 to 80 degrees Fahrenheit.", "60.An apparatus comprising: a mattress, the mattress comprising a first horizontal layer, a second horizontal layer positioned below the first horizontal layer, and a third horizontal layer positioned below the second horizontal layer; wherein the first horizontal layer comprises latex foam; wherein the second horizontal layer comprises memory foam; wherein the third horizontal layer comprises polyurethane foam; and wherein the second horizontal layer has a density of between 2 and 6 pounds per cubic foot.", "61.The apparatus as in claim 60, wherein the second horizontal layer has an airflow of at least 1 cubic feet per minute.", "62.The apparatus as in claim 60, wherein the second horizontal layer has a support factor of less than 2.6.63.The apparatus as in claim 60, wherein the second horizontal layer has a glass transition temperature of between 40 to 80 degrees Fahrenheit.", "64.The apparatus as in claim 52, wherein the second horizontal layer has a 25% IFD of between 6 and 18 pounds.", "65.The apparatus as in claim 64, wherein the second horizontal layer has an airflow of at least 1 cubic feet per minute.", "66.The apparatus as in claim 64, wherein the second horizontal layer has a support factor of less than 2.6.67.The apparatus as in claim 64, wherein the second horizontal layer has a glass transition temperature of between 40 to 80 degrees Fahrenheit.", "68.The apparatus as in claim 52, wherein the second horizontal layer has a density of between 2 and 6 pounds per cubic foot.", "69.The apparatus as in claim 68, wherein the second horizontal layer has an airflow of at least 1 cubic feet per minute.", "70.The apparatus as in claim 68, wherein the second horizontal layer has a support factor of less than 2.6.71.The apparatus as in claim 68, wherein the second horizontal layer has a glass transition temperature of between 40 to 80 degrees Fahrenheit.", "72.The apparatus as in claim 56, wherein the second horizontal layer has a density of between 2 and 6 pounds per cubic foot.", "73.The apparatus as in claim 72, wherein the second horizontal layer has an airflow of at least 1 cubic feet per minute.", "74.The apparatus as in claim 72, wherein the second horizontal layer has a support factor of less than 2.6.75.The apparatus as in claim 72, wherein the second horizontal layer has a glass transition temperature of between 40 to 80 degrees Fahrenheit.", "76.The apparatus as in claim 52, wherein the second horizontal layer has a 25% IFD of between 6 and 18 pounds; and the second horizontal layer has a density of between 2 and 6 pounds per cubic foot.", "77.The apparatus as in claim 76, wherein the second horizontal layer has an airflow of at least 1 cubic feet per minute.", "78.The apparatus as in claim 76, wherein the second horizontal layer has a support factor of less than 2.6.79.The apparatus as in claim 76, wherein the second horizontal layer has a glass transition temperature of between 40 to 80 degrees Fahrenheit.", "80.An apparatus comprising: a mattress, the mattress comprising a first horizontal layer, a second horizontal layer positioned below the first horizontal layer, and a third horizontal layer positioned below the second horizontal layer; wherein the first horizontal layer comprises latex foam; wherein the second horizontal layer comprises memory foam; wherein the third horizontal layer comprises polyurethane foam; and wherein the third horizontal layer has a density of between 1 and 4 pounds per cubic foot.", "81.The apparatus as in claim 80, wherein the third horizontal layer has a 25% IFD of between 15 to 50 pounds.", "82.An apparatus comprising: a mattress, the mattress comprising a first horizontal layer, a second horizontal layer positioned below the first horizontal layer, and a third horizontal layer positioned below the second horizontal layer; wherein the first horizontal layer comprises latex foam; wherein the second horizontal layer comprises memory foam; wherein the third horizontal layer comprises polyurethane foam; and wherein the third horizontal layer has a 25% IFD of between 15 to 50 pounds." ], [ "<SOH> BACKGROUND <EOH>Although the traditional spring mattress is the dominant category of mattresses sold within the United States, both latex foam mattresses and visco-elastic (memory) foam mattresses have been sold in the U.S. as specialty-category mattresses.", "Both latex and memory foams have benefits and drawbacks in mattress construction and design.", "Latex foam has a very quick recovery rate (i.e., is “bouncy”), is highly breathable and can be produced using natural or synthetic materials.", "If natural materials are used, the mattress can be marketed as such, adding to its desirability in the marketplace.", "Nonetheless, latex foam mattresses have the highest average return rate of any type of mattress sold in the U.S.—usually due to the resonant “bouncing” that the user feels on a latex foam mattress and/or inadequate pressure relief The market for memory foam mattresses was built nearly single-handedly by Tempur-Pedic through novel marketing techniques, such as an association with space-age technology and the image of a handprint “stuck” in the foam top layer after the hand is removed.", "Due to its slow recovery (or memory), visco-elastic memory foam was marketed as an aid for pressure relief and to enable isolation of one sleeper from another because the foam does not translate vibration.", "But memory foam mattresses also have a somewhat high return rate, often due to complaints such as: 1) “getting stuck” (i.e., not being able to turn over when changing sleeping positions); 2) overheating (the foam is not highly breathable and the contouring causes the foam to closely hug large portions of the body limiting air flow); and 3) not being conducive for comfort during sex because of the tendency to “get stuck.” Further, both latex and memory foam are expensive materials.", "Manufacturers often use them only for the top layer(s) of a mattress, often referred to as the comfort layer(s).", "The comfort layer(s) are usually 1-5″ thick and typically consist of 1-3 different foam types laminated together.", "Beneath these layer(s), regular polyurethane foam is typically used to provide some support and to increase mattress thickness.", "Some newer “hybrid” mattresses use pocketed spring coils instead of polyurethane foam.", "To combat the “stuck” feeling of memory foam, some manufacturers have developed quick-response memory foam.", "Other manufacturers use thinner layers of memory foam (atop poly foam) to limit the depth that user can sink into the foam.", "A few manufacturers have put latex foam underneath the memory foam to benefit from the quick return (i.e.", "bounce) that the latex foam provides.", "But this solution may not solve the problems noted above where memory foam is the top layer of the mattress.", "Accordingly, there is a need for a novel foam mattress construction that couples the contouring pressure relief of memory foam with quick-recovery of latex foam that prevents users from getting “stuck” in the memory foam and improves the springiness of the mattress.", "Such an arrangement will benefit from the breathability and bounciness of latex foam while mitigating the resonant bouncing and poorer pressure relief characteristics of latex foam." ], [ "<SOH> BRIEF DESCRIPTION OF THE FIGURES <EOH>The accompanying figures, where like reference numerals refer to identical or functionally similar elements throughout the separate views, together with the detailed description below, are incorporated in and form part of the specification, and serve to further illustrate embodiments of concepts that include the claimed invention, and explain various principles and advantages of those embodiments.", "FIG.", "1 is a cross-section view of a three-layer mattress in accordance with some embodiments.", "FIG.", "2 is a cross-section view of a four-layer mattress in accordance with some embodiments.", "FIG.", "3 is a cross-section view of a five-layer mattress in accordance with some embodiments.", "FIGS.", "4A and 4B are perspective views of a rolled-up mattress in accordance with some embodiments.", "FIGS.", "5A and 5B are perspective views of a mattress with a removable cover in accordance with some embodiments.", "FIGS.", "6A and 6B are perspective views of a mattress with a removable cover in accordance with some embodiments.", "FIGS.", "7A, 7B and 7C are perspective views of a mattress with a button-down cover in accordance with some embodiments.", "detailed-description description=\"Detailed Description\" end=\"lead\"?", "Skilled artisans will appreciate that elements in the figures are illustrated for simplicity and clarity and have not necessarily been drawn to scale.", "For example, the dimensions of some of the elements in the figures may be exaggerated relative to other elements to help to improve understanding of embodiments of the present invention.", "The apparatus and method components have been represented where appropriate by conventional symbols in the drawings, showing only those specific details that are pertinent to understanding the embodiments of the present invention so as not to obscure the disclosure with details that will be readily apparent to those of ordinary skill in the art having the benefit of the description herein." ], [ "RELATED APPLICATIONS This application claims the benefit of the U.S.", "Provisional Patent Application Ser.", "No.", "61/982,235 filed on Apr.", "21, 2014.FIELD OF THE DISCLOSURE The present disclosure is directed to a foam mattress with improved features related to its construction, transportation and cleaning.", "BACKGROUND Although the traditional spring mattress is the dominant category of mattresses sold within the United States, both latex foam mattresses and visco-elastic (memory) foam mattresses have been sold in the U.S. as specialty-category mattresses.", "Both latex and memory foams have benefits and drawbacks in mattress construction and design.", "Latex foam has a very quick recovery rate (i.e., is “bouncy”), is highly breathable and can be produced using natural or synthetic materials.", "If natural materials are used, the mattress can be marketed as such, adding to its desirability in the marketplace.", "Nonetheless, latex foam mattresses have the highest average return rate of any type of mattress sold in the U.S.—usually due to the resonant “bouncing” that the user feels on a latex foam mattress and/or inadequate pressure relief The market for memory foam mattresses was built nearly single-handedly by Tempur-Pedic through novel marketing techniques, such as an association with space-age technology and the image of a handprint “stuck” in the foam top layer after the hand is removed.", "Due to its slow recovery (or memory), visco-elastic memory foam was marketed as an aid for pressure relief and to enable isolation of one sleeper from another because the foam does not translate vibration.", "But memory foam mattresses also have a somewhat high return rate, often due to complaints such as: 1) “getting stuck” (i.e., not being able to turn over when changing sleeping positions); 2) overheating (the foam is not highly breathable and the contouring causes the foam to closely hug large portions of the body limiting air flow); and 3) not being conducive for comfort during sex because of the tendency to “get stuck.” Further, both latex and memory foam are expensive materials.", "Manufacturers often use them only for the top layer(s) of a mattress, often referred to as the comfort layer(s).", "The comfort layer(s) are usually 1-5″ thick and typically consist of 1-3 different foam types laminated together.", "Beneath these layer(s), regular polyurethane foam is typically used to provide some support and to increase mattress thickness.", "Some newer “hybrid” mattresses use pocketed spring coils instead of polyurethane foam.", "To combat the “stuck” feeling of memory foam, some manufacturers have developed quick-response memory foam.", "Other manufacturers use thinner layers of memory foam (atop poly foam) to limit the depth that user can sink into the foam.", "A few manufacturers have put latex foam underneath the memory foam to benefit from the quick return (i.e.", "bounce) that the latex foam provides.", "But this solution may not solve the problems noted above where memory foam is the top layer of the mattress.", "Accordingly, there is a need for a novel foam mattress construction that couples the contouring pressure relief of memory foam with quick-recovery of latex foam that prevents users from getting “stuck” in the memory foam and improves the springiness of the mattress.", "Such an arrangement will benefit from the breathability and bounciness of latex foam while mitigating the resonant bouncing and poorer pressure relief characteristics of latex foam.", "BRIEF DESCRIPTION OF THE FIGURES The accompanying figures, where like reference numerals refer to identical or functionally similar elements throughout the separate views, together with the detailed description below, are incorporated in and form part of the specification, and serve to further illustrate embodiments of concepts that include the claimed invention, and explain various principles and advantages of those embodiments.", "FIG.", "1 is a cross-section view of a three-layer mattress in accordance with some embodiments.", "FIG.", "2 is a cross-section view of a four-layer mattress in accordance with some embodiments.", "FIG.", "3 is a cross-section view of a five-layer mattress in accordance with some embodiments.", "FIGS.", "4A and 4B are perspective views of a rolled-up mattress in accordance with some embodiments.", "FIGS.", "5A and 5B are perspective views of a mattress with a removable cover in accordance with some embodiments.", "FIGS.", "6A and 6B are perspective views of a mattress with a removable cover in accordance with some embodiments.", "FIGS.", "7A, 7B and 7C are perspective views of a mattress with a button-down cover in accordance with some embodiments.", "Skilled artisans will appreciate that elements in the figures are illustrated for simplicity and clarity and have not necessarily been drawn to scale.", "For example, the dimensions of some of the elements in the figures may be exaggerated relative to other elements to help to improve understanding of embodiments of the present invention.", "The apparatus and method components have been represented where appropriate by conventional symbols in the drawings, showing only those specific details that are pertinent to understanding the embodiments of the present invention so as not to obscure the disclosure with details that will be readily apparent to those of ordinary skill in the art having the benefit of the description herein.", "DETAILED DESCRIPTION I. Definitions In this disclosure, the listed terms will be defined as follows: Density of a foam is its mass per unit volume.", "Density may be measured in pounds per cubic foot (pcf).", "IFD is Indentation Force Deflection, which is a method for determining the firmness, and load bearing capacity of foam.", "IFD measures the load required to depress a 50 square inch compression platen into a foam specimen.", "IFD is usually reported at 25% deflection of the specimen's height and is measured in pounds.", "IFD may be measured with ASTM D3574-11 Test B1.Airflow is a measure of the air permeability of a foam and is measured in cubic feet per minute (cfm).", "Airflow may be measured with ASTM D3574-11 Test G. Recovery is a measure of how quickly a foam returns to original shape after being displaced and is measured in seconds.", "Recovery is typically used to measure the memory effect of visco-elastic foams.", "Recovery may be measured with ASTM D3574-11 Test M. Rebound is measure of the elasticity of a foam and is measured as a percentage.", "A steel ball is dropped on a foam specimen, and the percentage height it rebounds (relative to drop height) is measured.", "Rebound may be measured with ASTM D3574-11 Test H. Support Factor (SF) is the ratio of 65% IFD over 25% IFD and is a unitless measurement.", "SF is a measure of the “deeper” support of a foam, and is an indicator as to whether a foam will bottom out or not.", "SF may be measured with ASTM D3574-11 Test B1.Tg is the glass transition temperature of the foam.", "It is a property of all foams but is most relevant with memory foams because memory foams have a Tg within the range of normal ambient temperature (40° F.-80° F.).", "Tg is the point at which a foam transitions from stiff to pliable.", "Below Tg, a foam is stiff.", "Above Tg, a foam is pliable.", "The transition in mechanical properties can be dramatic, even with but a few degrees change in temperature.", "Tg, may be measured with dynamic mechanical analysis (DMA) or thermal stress analysis (TSA).", "Latex foam is any high resilience foam where: i) a rebound may be greater than 40%; ii) airflow may be greater than 3.5 cfm; and iii) recovery may be less than 0.5 seconds.", "Latex foam may be natural latex, styrene butadiene rubber (SBR), polyurethane or any blend of the above foams.", "Latex-like foam is any foam intended to simulate the mechanical properties of latex foam—(i) a rebound may be greater than 40%; ii) airflow may be greater than 3.5 cfm; and iii) recovery may be less than 0.5 seconds—but with polyurethane, polyethylene or other non-natural or non-SBR resins or any blend of the above foams.", "Memory foam is any polyurethane foam with a low rebound, delayed recovery and a temperature-sensitive response.", "More specifically: i) the rebound may be from 1-2%; ii) the recovery may be greater than 1 second; and iii) the temperature-sensitive response may be the foam softening in response to body heat and having a Tg between 40° F. and 80° F. II.", "Mattress Length and Width The mattresses described herein may be of any suitable length and width, including without limitation U.S. or non-U.S. standard sizes such as King, Queen, Full, Twin, Extra Long, California King, Youth and Crib.", "III.", "The Three-Layer Mattress Turing to FIG.", "1, shown is cross-section of a three-layer mattress 100 with a cover 110.The cross-section of the depth of the mattress 100 includes a first layer 120, a second layer 130 and a third layer 140.A.", "First Embodiment In a first embodiment, the total depth 180 of the mattress 100 may be 9.5 inches.", "The first layer depth 150 of the mattress 100 may be 1.5 inches.", "The second layer depth 160 of the mattress may be 1.5 inches.", "The third layer depth 170 of the mattress may be 6.5 inches.", "In this first embodiment, the first layer 120 is a layer of latex foam.", "The first layer 120 may consist of C1 latex from Mountain Top Foam and may have the physical properties shown in Table 1.TABLE 1 Test Potential Target Tolerance Unit Method Range Unit Density 3.3 ±0.2 pcf n/a 2 to 4 pcf 25% IFD 12 ±1 lb ASTM 6 to 18 lb D3574-11 Test B1 Airflow >4 minimum cfm ASTM >2 cfm D3574-11 Test G Recovery <0.5 maximum seconds ASTM <1 seconds D3574-11 Test M Rebound 65 ±5 % ASTM >40 % D3574-11 Test H Support 3 ±0.1 n/a ASTM >2 n/a Factor D3574-11 Test B1 Tg n/a In Table 1, the rightmost two columns demonstrate potential ranges of physical properties related to the first layer 120.The second layer 130 is a layer of memory foam.", "The second layer 130 may consist of 4 lb Visco memory foam and may have the physical properties shown in Table 2.TABLE 2 Test Potential Target Tolerance Unit Method Range Unit Density 4.0 ±0.1 pcf n/a 2 to 6 pcf 25% IFD 10 ±1 lb ASTM 6 to 18 lb D3574-11 Test B1 Airflow >2 minimum cfm ASTM >1 cfm D3574-11 Test G Recovery 3 ±1 seconds ASTM >1 seconds D3574-11 Test M Rebound 2 maximum % ASTM <5 % D3574-11 Test H Support 2.2 ±0.1 n/a ASTM <2.6 n/a Factor D3574-11 Test B1 Tg 60 ±2 ° F. DMA 40 to 80 ° F. In Table 2, the rightmost two columns demonstrate potential ranges of physical properties related to the second layer 130.In the mattress industry, two important parameters used to describe a foam are IFD and SF.", "Standard test protocols specify the test specimen size and loading regime for these parameters, which creates measurement consistency.", "Such test protocols may be found in ASTM D3574-11.IFD is an indication of foam firmness and indicates how much force a foam pushes back with when a user pushes into it.", "Industry norms use 25% IFD numbers as a basis for comparison—so an IFD 8 foam (8 pounds of push-back) feels softer than a IFD 20 foam (20 pounds of push-back).", "SF represents the “deeper” support of a foam, and is an indicator as to whether a foam will bottom out or not.", "SF is the ratio of the 65% IFD to the 25% IFD—the ratio of the force required to depress a sample to 65% of its original height to the force required to depress a sample to 25% of its original height (the standard IFD measurement).", "SF illustrates how much a single type of foam pushes back the more the user pushes into it.", "Thus, a foam with a SF of 3 and an IFD of 8 pushes back with 24 pounds force upon 65% compression, while an IFD 8 foam with a SF of 2 only pushes back with 16 pounds at 65% compression.", "A linear “spring” foam generally has a SF of 2.6.Latex and latex-like foam typically have a higher SF (approximately 3.0-3.3).", "Memory foam typically has a lower SF (approximately 2.0-2.2).", "These differences are quite significant in the overall feel of the mattress.", "In the mattress industry, it has been a widely accepted rule of thumb that the top layers of foam should have the lowest SF to reduce pressure points, and that the SF should increase as one moves down into the layers.", "By having the first layer 120 being comprised of a latex or latex-like foam and placed on top of the second layer 130 being comprised of memory foam, the commonly-held rule regarding SF is inverted.", "Nonetheless, a successful experience for the mattress user is achieved because the foam layers of the bed act as a series of springs.", "This arrangement eliminates the “stuckness” of memory foam while retaining the pressure relief and motion isolation of the memory foam.", "At the same time, this arrangement benefits from the breathability and bounciness of latex or latex-like foam while mitigating the resonant bouncing and poorer pressure relief characteristics of latex or latex-like foam.", "The third layer 140 adds overall support and depth for the mattress and may consist of 1.8 pcf conventional polyurethane foam and may have the physical properties shown in Table 3.TABLE 3 Test Potential Target Tolerance Unit Method Range Unit Density 1.8 ±0.1 Pcf n/a 1 to 4 pcf 25% IFD 32 ±3 Lb ASTM 15 to lb D3574-11 50 Test B1 Airflow >4 minimum Cfm ASTM >2 cfm D3574-11 Test G Recovery <0.5 maximum Seconds ASTM <1 seconds D3574-11 Test M Rebound 50 ±5 % ASTM >40 % D3574-11 Test H Support 1.9 ±0.1 n/a ASTM 1.5 to n/a Factor D3574-11 3.5 Test B1 Tg n/a In Table 3, the rightmost two columns demonstrate potential ranges of physical properties related to the third layer 140.B.", "The Second Embodiment In a second embodiment, the total depth 180 of the mattress 100 may range from 1 to 22 inches.", "The first layer depth 150 of the mattress 100 may range from 0.25 to 5 inches.", "The second layer depth 160 of the mattress may range from 0.25 inches to 5 inches.", "The third layer depth 170 of the mattress may range from 0.5 to 12 inches.", "The second embodiment is similar to the first embodiment in that the first layer 120 is latex or latex-like foam and the second layer 130 is memory foam.", "The third layer 140 may be any of the following: i) latex foam; ii) latex-like foam; iii) polyurethane visco-elastic “memory” foam; iv) conventional polyurethane foam; v) HR (high resilience) polyurethane foam; or vi) any other polyurethane, polyethylene or polyester Foam.", "IV.", "The Four-Layer Mattress Turing to FIG.", "2, shown is cross-section of a four-layer mattress 200 with a cover 210.The cross-section of the depth of the mattress 200 includes a first layer 220, a second layer 230, a third layer 240 and a fourth layer 250.The total depth 295 of the mattress 200 may range from 1 to 22 inches.", "The first layer depth 260 of the mattress 200 may range from 0.25 to 5 inches.", "The second layer depth 270 of the mattress may range from 0.25 inches to 5 inches.", "The third layer depth 280 of the mattress may range from 0.25 to 5 inches.", "The fourth layer depth 290 of the mattress may range from 0.25 to 12 inches.", "The first layer 220 may be latex or latex-like foam.", "The second layer 230, third layer 240 and fourth layer 250 may be any of the following: i) latex foam; ii) latex-like foam; iii) polyurethane visco-elastic “memory” foam; iv) conventional polyurethane foam; v) HR (high resilience) polyurethane foam; or vi) any other polyurethane, polyethylene or polyester foam.", "In one embodiment, at least one of the second layer 230, third layer 240 and fourth layer 250 is memory foam.", "In one embodiment, at least one upper layer has a SF higher than a layer below that upper layer.", "V. The Five-Layer Mattress Turing to FIG.", "3, shown is cross-section of a five-layer mattress 300 with a cover 305.The cross-section of the depth of the mattress 300 includes a first layer 310, a second layer 315, a third layer 320, a fourth layer 325 and a fifth layer 330.The total depth 360 of the mattress 300 may range from 1.25 to 22 inches.", "The first layer depth 335 of the mattress 300 may range from 0.25 to 5 inches.", "The second layer depth 340 of the mattress may range from 0.25 inches to 5 inches.", "The third layer depth 345 of the mattress may range from 0.25 to 5 inches.", "The fourth layer depth 350 of the mattress may range from 0.25 to 5 inches.", "The fifth layer depth 355 of the mattress may range from 0.25 to 12 inches.", "The first layer 310 may be latex or latex-like foam.", "The second layer 315, third layer 320, fourth layer 325 and fifth layer 330 may be any of the following: i) latex foam; ii) latex-like foam; iii) polyurethane visco-elastic “memory” foam; iv) conventional polyurethane foam; v) HR (high resilience) polyurethane foam; or vi) any other polyurethane, polyethylene or polyester Foam.", "In one embodiment, at least one of the second layer 315, third layer 320, fourth layer 325 and fifth layer 330 is memory foam.", "In one embodiment, at least one upper layer has a SF higher than a layer below that upper layer.", "VI.", "Mattress Transportation Moving a mattress is a cumbersome task.", "For example, queen-sized mattresses can weigh up to 100 pounds, and are typically floppy with poor affordance for carrying.", "They are difficult to get through doorways, down stairs and into cars.", "As such, many people will discard mattresses when they move because the burdens and costs of moving a mattress are too great.", "Turing to FIG.", "4A, shown is a mattress system 400 with two features that facilitate moving so that mattresses are not discarded and have greater long-term value to their owner.", "The mattress body 405 incorporates straps 410, 412, 414 integrated into the design that hold the mattress in an easily transportable shape once rolled up or folded.", "The straps may be webbing, string or any other material with high tensile strength.", "The straps may tie, have buckles or incorporate any other fasteners 420, 422, 424 that enable the straps to hold the mattress together.", "The user manually rolls up and/or folds the mattress, and the straps are located in a convenient place such that once rolled, the mattress may easily be strapped together.", "By integrating the straps, the rolling and strapping process is easier and ensures that all users have the proper materials at hand to roll the mattress for transport.", "Turing to FIG.", "4B, shown is another view of the mattress system 400.In addition to the straps 410, 412, 44, the mattress body 405 has integrated backpack, shoulder and/or hand straps 420, 430 installed via a securing mechanism 440 that allow the mattress body 405 to be readily carried by one or more people on their shoulders and/or back.", "This greatly facilitates portability, increasing the odds that an owner will take their mattress with them to their new home and be able to do so with minimal hassle.", "In another embodiment, the cinch straps and carrying straps are part of a separate “wrap” or bag rather than integrated into the mattress.", "VII.", "Integrated Mattress Washable Pad Mattresses are expensive investments that often become stained with sweat and/or other bodily fluids.", "Even when used with sheets and a mattress pad (a separately-purchased cover that is used to protect the mattress), mattresses become stained.", "In nearly all cases, the cover of the mattress itself is not washable other than through spot cleaning.", "A limited number of mattresses (often futon-style) may have a cover that completely zips off and can be laundered, but this is often a cumbersome process because it requires a lot of manipulation of the heavy mattress.", "Staining of mattresses limits their resale value and can prevent people from giving a mattress to friends when they decide to move town or upgrade to a different mattress.", "Turing to FIG.", "5A, shown is a mattress system 500 including a mattress body 510 and of a removable section of a detachable mattress cover 520 that protects the primary mattress cover from stains and that can be washed or replaced with a new one in order to “refresh” the mattress.", "In this embodiment, the mattress cover 520 covers the entire top of the mattress body 510 and is secured to the mattress body 510 by a securing mechanism 530.It may be reversible to quickly provide a clean top surface, and it may have different colors from the mattress body 510 in order to better hide stains.", "The securing mechanism 530 may be secured at approximately the same depth all around the mattress body 510 and may consist of hook and loop fasteners, zippers, buttons, snaps, ties or any combination thereof Turing to FIG.", "5B, shown is a mattress system 505 including a mattress body 510 and a removable section of a detachable mattress cover 550 that protects the primary mattress cover from stains and that can be washed or replaced with a new one in order to “refresh” the mattress.", "In this embodiment, the mattress cover 550 covers a portion of the top of the mattress body 510 and is secured to the mattress body 510 by a securing mechanism 540.The mattress cover 550 may be located in the area most likely to absorb bodily fluids (in the region from the head to the upper thigh).", "It may cover just the top of the mattress body 510 so it can be easily removed and laundered.", "It may be reversible to quickly provide a clean top surface, and it may have different colors from the primary mattress in order to better hide stains.", "The securing mechanism 540 may be secured at approximately the same depth around the mattress body 510 to best secure the mattress cover 550 The securing mechanism 540 may consist of hook and loop fasteners, zippers, buttons, snaps, ties or any combination thereof Turing to FIGS.", "6A and 6B, shown is a mattress system 600 with a removable mattress pad 610 that surrounds a portion of the mattress body 510.The mattress pad 610 may be placed in the area most likely to absorb bodily fluids (in the region from the head to the upper thigh).", "It may cover just the top of the mattress body 510 so it can be easily removed and laundered.", "It may be reversible to quickly provide a clean top surface, and it may have different colors from the primary mattress in order to better hide stains.", "Turing to FIG.", "7A, shown is a mattress system 700 with a removable mattress pad 730.It is secured to the mattress body 510 via a button 710 attached to the mattress body 510 and a button hole 720 installed in the mattress pad 730.Turning to FIG.", "7B, shown is a mattress system 704 where the mattress pad 730 is attached to the mattress body (not shown) by means of the button 710 attached to the mattress.", "Turning to FIG.", "7C, shown is a mattress system 706 where the mattress pad 750 is attached to a portion of the mattress body 760 via a button 710 attached to the mattress body 760.The mattress pads 730, 750 may be reversible to quickly provide a clean top surface, and may have different colors from the primary mattress in order to better hide stains.", "In the foregoing specification, specific embodiments have been described.", "However, one of ordinary skill in the art appreciates that various modifications and changes can be made without departing from the scope of the invention as set forth in the claims below.", "Accordingly, the specification and figures are to be regarded in an illustrative rather than a restrictive sense, and all such modifications are intended to be included within the scope of present teachings.", "The benefits, advantages, solutions to problems, and any element(s) that may cause any benefit, advantage, or solution to occur or become more pronounced are not to be construed as critical, required, or essential features or elements of any or all the claims.", "The invention is defined solely by the appended claims including any amendments made during the pendency of this application and all equivalents of those claims as issued.", "Moreover in this document, relational terms such as first and second, top and bottom, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions.", "The terms “comprises,” “comprising,” “has”, “having,” “includes”, “including,” “contains”, “containing” or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises, has, includes, contains a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.", "An element proceeded by “comprises .", ".", ".", "a”, “has .", ".", ".", "a”, “includes .", ".", ".", "a”, “contains .", ".", ".", "a” does not, without more constraints, preclude the existence of additional identical elements in the process, method, article, or apparatus that comprises, has, includes, contains the element.", "The terms “a” and “an” are defined as one or more unless explicitly stated otherwise herein.", "The terms “substantially”, “essentially”, “approximately”, “about” or any other version thereof, are defined as being close to as understood by one of ordinary skill in the art.", "The term “coupled” as used herein is defined as connected, although not necessarily directly and not necessarily mechanically.", "A device or structure that is “configured” in a certain way is configured in at least that way, but may also be configured in ways that are not listed.", "The Abstract of the Disclosure is provided to allow the reader to quickly ascertain the nature of the technical disclosure.", "It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.", "In addition, in the foregoing Detailed Description, it can be seen that various features are grouped together in various embodiments for the purpose of streamlining the disclosure.", "This method of disclosure is not to be interpreted as reflecting an intention that the claimed embodiments require more features than are expressly recited in each claim.", "Rather, as the following claims reflect, inventive subject matter lies in less than all features of a single disclosed embodiment.", "Thus the following claims are hereby incorporated into the Detailed Description, with each claim standing on its own as a separately claimed subject matter." ] ]
Patent_15872737
[ [ "PNEUMATIC VEHICLE TIRE", "A pneumatic vehicle tire has a nominal tire cross-sectional height H of at most 110 mm, bead regions with bead cores, a radial carcass which runs around the bead cores in the bead regions axially on the inside to axially on the outside forming carcass turn-ups, and side wall regions, which each have a wing profile and a side wall profile.", "The wing profiles are the only rubber components extending in contact with the radial carcass in the radially outer region of the side wall region.", "The carcass turn-ups end at a radial height (h1), determined from a base line, of 15 mm to 65 mm.", "At least in a region between a radial height (h2) of 29% of the nominal side wall height and a radial height (h3) of at least 80% of the height H, the wing profiles are the only rubber components that extend outside the radial carcass." ], [ "1.A pneumatic vehicle tire comprising: a tread including tread edge regions; the pneumatic vehicle tire having a nominal tire cross-sectional height (H) of at most 110 mm; a belt assembly; bead regions each having a bead core and horn profile; a radial carcass running around each bead core in each bead region axially on the inside to axially on the outside forming carcass turn-ups; side wall regions each having a wing profile and a side wall profile; said wing profiles being the only rubber components extending in contact with said radial carcass in radially outer regions of said side wall regions; said wing profiles each having a radially inner end section which runs out in a tapered manner in the direction of said bead regions and which overlaps corresponding side wall profiles on the outside; said wing profiles each further having respective radially outer end sections, which run out at corresponding ones of said tread edge regions; said side wall profiles each being, in cross section, a substantially strip-shaped rubber component arranged between corresponding ones of said wing profiles and horn profiles; said carcass turn-ups ending at a radial height (h1) of 15 mm to 65 mm determined from a base line (BL); said wing profiles being, at least in respective regions between a radial height (h2) determined from said base line (BL) of 29% of a nominal side wall height, and a radial height (h3) determined from said base line (BL) of at least 80% of said tire cross-sectional height (H), the only rubber components that extend outside said radial carcass; and, said base line (BL) extending in the axial direction and being configured to intersect a rim where an outer end of a rim radius is situated.", "2.The pneumatic vehicle tire of claim 1, wherein said wing profiles, from a height (h2) of 25% of the nominal side wall height, are the only rubber components that extend outside said radial carcass.", "3.The pneumatic vehicle tire of claim 1, wherein, in the direction of said tread up to said height (h3) of up to 90% of said tire cross-sectional height (H), said wing profiles are the only rubber components that extend outside said radial carcass.", "4.The pneumatic vehicle tire of claim 1, wherein: said wing profiles have a thickness (d) perpendicular to the extent of said radial carcass in said side wall regions in which said wing profiles are the only rubber components extending outside the radial carcass; and, said sidewall thickness (d) lies in a range from 1.0 mm to 3.5 mm.", "5.The pneumatic vehicle tire of claim 1, wherein: said wing profiles have a thickness (d) perpendicular to the extent of said radial carcass in said side wall regions in which they are the only rubber components extending outside the radial carcass; and, said sidewall thickness (d) is 2.5 mm.", "6.The pneumatic vehicle tire of claim 1, wherein: said wing profiles have a thickness (d) perpendicular to the extent of said radial carcass in said side wall regions in which they are the only rubber components extending outside the radial carcass; and, said sidewall thickness (d) is at least 1.5 mm.", "7.The pneumatic vehicle tire of claim 1, wherein: said wing profiles have a thickness (d) perpendicular to the extent of said radial carcass in said side wall regions in which they are the only rubber components extending outside the radial carcass; and, said sidewall thickness (d) is at most 1.8 mm.", "8.The pneumatic vehicle tire of claim 1, wherein: said wing profiles have a thickness (d) perpendicular to the extent of said radial carcass in said side wall regions in which they are the only rubber components extending outside the radial carcass; and, said sidewall thickness (d) is substantially constant.", "9.The pneumatic vehicle tire of claim 1, wherein: said horn profiles each have a radially outer horn profile end section; corresponding ones of said side wall profiles, said radially outer horn profile end sections and said wing profiles each form a rim protection rib in said side wall regions; and, said rim protection ribs each having, perpendicularly to the extent of the radial carcass, a maximum thickness lying in a range from 4 mm to 14 mm." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Such a pneumatic vehicle tire is known from US2014/0027034.In the case of this pneumatic vehicle tire, the wing profiles are the only rubber components that extend in the radially outer regions of the side walls, and therefore the rubber thickness in these regions can be kept less than in embodiments in which the side wall profiles and wing profiles overlap in this region.", "In the case of this known tire, provision is furthermore made for the turn-ups of the radial carcass to be folded back so as to extend under the belt assembly.", "However, this known tire has such a high radial stiffness in the side wall regions that it is in need of improvement in respect especially of its handling characteristics and of the road noise transmitted into the interior of the vehicle." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>It is an object of the invention to eliminate the above mentioned disadvantages and furthermore to enable the pneumatic vehicle tire to be made even slimmer in the side wall regions.", "The object can, for example, be achieved by virtue of the fact that the carcass turn-ups end at a radial height, determined from a base line, of 15 mm to 65 mm, and that, at least in a region between a radial height, determined from the base line, of 29% of the nominal side wall height and a radial height, determined from the base line, of at least 80% of the tire cross-sectional height, the wing profiles are the only rubber components that extend outside the radial carcass, wherein the base line extends in the axial direction and intersects the rim where the outer end of the rim radius is situated.", "In the case of a tire embodied in accordance with the invention, the head region of the tire is to a large extent mechanically decoupled from the bead regions of the tire, especially as a result of the lower radial stiffness that can be achieved in the side wall regions.", "The carcass turn-ups ending at a relatively low height and the relatively large region within which only the wing profiles extend as rubber components are responsible for the decoupling.", "The folding back of the carcass turn-ups under the belt assembly—the term “C ply” being used here—which is provided in the embodiment known from US2014/0027034, results in increased shoulder pressure of the tire in the ground contact area in the sensitive shoulder regions.", "This increased shoulder pressure can also result in increased shoulder abrasion.", "In the case of tires embodied in accordance with the invention, the wing profiles can furthermore be made very thin, thus further reducing the radial side wall stiffness.", "Pneumatic vehicle tires with a low side wall thickness have better handling characteristics since they can deflect to a greater extent.", "This increases, in particular, the dynamic ground contact area of the tire, this being associated with better power transmission and therefore improved handling characteristics.", "The mechanical decoupling already mentioned furthermore has the effect of reducing tire noise in the interior of the vehicle.", "By virtue of the possibility of reducing the rubber thickness in the side wall regions even further, it is additionally possible to achieve a weight saving, which results in a significant improvement in the rolling resistance of the tire.", "An embodiment of the invention in which, from a height of 25% of the nominal side wall height, the wing profiles are the only rubber components that extend outside the radial carcass, is particularly preferred.", "In the direction of the tread up to a height of up to 90% of the tire cross-sectional height, the wing profiles are in this case preferably the only rubber components that extend outside the radial carcass.", "This embodiment is advantageous for particularly effective reduction of the radial side wall stiffness.", "According to another advantageous embodiment, the thickness of the wing profiles perpendicularly to the extent of the radial carcass in those side wall regions in which they are the only rubber components extending outside the radial carcass is 1.0 mm to 3.5 mm, in particular up to 2.5 mm.", "A thickness of the wing profiles in these regions of 1.5 mm to 1.8 mm is particularly advantageous.", "In this case, the thickness of the wing profiles in these side wall regions should be substantially constant.", "In each side wall region, the side wall profile, the radially outer end section of the horn profile and the wing profile can furthermore advantageously form a rim protection rib, the maximum thickness of which perpendicularly to the extent of the radial carcass is 4.0 mm to 14.0 mm." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation application of international patent application PCT/EP2016/052677, filed Feb. 9, 2016 designating the United States and claiming priority from German application 10 2015 213 403.2, filed Jul.", "16, 2015, and the entire content of both applications is incorporated herein by reference.", "FIELD OF THE INVENTION The invention relates to a pneumatic vehicle tire having a nominal tire cross-sectional height of at most 110 mm, having a tread, a belt assembly, bead regions with bead cores and horn profiles, a radial carcass, which runs around the bead cores in the bead regions axially on the inside to axially on the outside, forming carcass turn-ups, and having side wall regions, which each have a wing profile and a side wall profile, wherein the wing profile is the only rubber component extending in contact with the radial carcass in the radially outer region of the side wall region and has a radially inner end section which runs out in a tapered manner in the direction of the bead region and which overlaps the side wall profile on the outside, and has a radially outer end section, which runs out at the tread edge region, and wherein, in cross section, the side wall profile is a substantially strip-shaped rubber component arranged between the wing profile and the horn profile.", "BACKGROUND OF THE INVENTION Such a pneumatic vehicle tire is known from US2014/0027034.In the case of this pneumatic vehicle tire, the wing profiles are the only rubber components that extend in the radially outer regions of the side walls, and therefore the rubber thickness in these regions can be kept less than in embodiments in which the side wall profiles and wing profiles overlap in this region.", "In the case of this known tire, provision is furthermore made for the turn-ups of the radial carcass to be folded back so as to extend under the belt assembly.", "However, this known tire has such a high radial stiffness in the side wall regions that it is in need of improvement in respect especially of its handling characteristics and of the road noise transmitted into the interior of the vehicle.", "SUMMARY OF THE INVENTION It is an object of the invention to eliminate the above mentioned disadvantages and furthermore to enable the pneumatic vehicle tire to be made even slimmer in the side wall regions.", "The object can, for example, be achieved by virtue of the fact that the carcass turn-ups end at a radial height, determined from a base line, of 15 mm to 65 mm, and that, at least in a region between a radial height, determined from the base line, of 29% of the nominal side wall height and a radial height, determined from the base line, of at least 80% of the tire cross-sectional height, the wing profiles are the only rubber components that extend outside the radial carcass, wherein the base line extends in the axial direction and intersects the rim where the outer end of the rim radius is situated.", "In the case of a tire embodied in accordance with the invention, the head region of the tire is to a large extent mechanically decoupled from the bead regions of the tire, especially as a result of the lower radial stiffness that can be achieved in the side wall regions.", "The carcass turn-ups ending at a relatively low height and the relatively large region within which only the wing profiles extend as rubber components are responsible for the decoupling.", "The folding back of the carcass turn-ups under the belt assembly—the term “C ply” being used here—which is provided in the embodiment known from US2014/0027034, results in increased shoulder pressure of the tire in the ground contact area in the sensitive shoulder regions.", "This increased shoulder pressure can also result in increased shoulder abrasion.", "In the case of tires embodied in accordance with the invention, the wing profiles can furthermore be made very thin, thus further reducing the radial side wall stiffness.", "Pneumatic vehicle tires with a low side wall thickness have better handling characteristics since they can deflect to a greater extent.", "This increases, in particular, the dynamic ground contact area of the tire, this being associated with better power transmission and therefore improved handling characteristics.", "The mechanical decoupling already mentioned furthermore has the effect of reducing tire noise in the interior of the vehicle.", "By virtue of the possibility of reducing the rubber thickness in the side wall regions even further, it is additionally possible to achieve a weight saving, which results in a significant improvement in the rolling resistance of the tire.", "An embodiment of the invention in which, from a height of 25% of the nominal side wall height, the wing profiles are the only rubber components that extend outside the radial carcass, is particularly preferred.", "In the direction of the tread up to a height of up to 90% of the tire cross-sectional height, the wing profiles are in this case preferably the only rubber components that extend outside the radial carcass.", "This embodiment is advantageous for particularly effective reduction of the radial side wall stiffness.", "According to another advantageous embodiment, the thickness of the wing profiles perpendicularly to the extent of the radial carcass in those side wall regions in which they are the only rubber components extending outside the radial carcass is 1.0 mm to 3.5 mm, in particular up to 2.5 mm.", "A thickness of the wing profiles in these regions of 1.5 mm to 1.8 mm is particularly advantageous.", "In this case, the thickness of the wing profiles in these side wall regions should be substantially constant.", "In each side wall region, the side wall profile, the radially outer end section of the horn profile and the wing profile can furthermore advantageously form a rim protection rib, the maximum thickness of which perpendicularly to the extent of the radial carcass is 4.0 mm to 14.0 mm.", "BRIEF DESCRIPTION OF THE DRAWING The invention will now be described with reference to the single FIG.", "of the drawing (FIG.", "1) which shows a cross section of half of a pneumatic vehicle tire.", "DESCRIPTION OF THE PREFERRED EMBODIMENTS OF THE INVENTION The size and dimension figures given herein refer to a tire mounted on a standard rim under a standard internal pressure but in the no-load state in accordance with E.T.R.T.O.", "standards in the current version.", "The radial distances or heights are determined from a base line BL, which extends in the axial direction and intersects the rim where the outer end of the rim radius is situated.", "The nominal width should be understood to be the nominal width in millimeters given in the tire dimension figures in accordance with the E.T.R.T.O.", "standards.", "Thus, in the tire dimension “235/35R19”, for example, the number 235 is the nominal width in millimeters and the number 35 is the nominal aspect ratio.", "According to this example, 35% of the nominal width of the tire therefore corresponds to the nominal side wall height, and this is therefore 82.25 mm in this example.", "Pneumatic vehicle tires embodied in accordance with the invention are passenger car tires of radial configuration with nominal side wall heights of up to 110 mm.", "The pneumatic vehicle tire shown in section in FIG.", "1 has a tread 1, bead regions 2 with bead cores 3, a one- or multi-part apex (core profile) 4 and a horn profile 5, and furthermore side wall profiles 6, a belt assembly 7, a radial carcass 8 and an airtight inner layer 9.As will be described below in detail, a wing profile 10 extends over each of the side wall regions of the pneumatic vehicle tire.", "The apex 4, the horn profile 5, the side wall profile 6 and the wing profile 10 are rubber profiles, which can be produced from the usual rubber compounds for these components.", "The tread 1, which is not the subject matter of the invention, can be embodied or constructed in a known manner, for example, in a single layer or in two layers with a tread base and a tread cap.", "The tread 1 is furthermore provided in a manner which is known but not shown with tread profiling and is produced by coextrusion together with the two wing profiles 10, which overlap with the tread edge regions.", "Generally, the wing profiles 10 are composed of the same rubber compound as the side wall profiles 6.However, the rubber compound of the wing profiles 10 can also differ from that of the side wall profiles 6.In a known manner, the radial carcass 8 has at least one ply composed of rubberized cords, in particular rubberized textile cords, which extend at least substantially in a radial direction.", "The carcass 8, which in each case extends from axially on the inside to axially on the outside around the bead cores 3, extends with its turned-over sections, the turn-ups 8a, to a height h1 of 15 mm to 65 mm.", "The bead assembly 7 has at least two belt plies 7a, 7b with strengthening members, in particular steel cords, which cross each other but run parallel in each ply.", "The belt plies 7a, 7b can be covered by a single- or multi-ply bandage (not shown), which consists in a known manner of bandage cords, for example, nylon cords, embedded in rubber and extending substantially in the circumferential direction.", "Together with the side wall profile 6 and the wing profile 10, that section of the horn profile 5 which extends axially outside the carcass turn-up 8a or carcass ply 8 forms a rim protection rib 11 having an edge K running around in a ring shape along the side wall region at the thickest point of the protection rib 11.The side wall region radially outside the edge K has a concavely rounded outer contour and, radially inside the edge K, a convexly curved section along the radially outer region of the horn profile 5.The greatest rubber thickness in the region of the rim protection rib 11, determined perpendicularly to the extent of the carcass 8, is between 4 mm and 14 mm.", "The wing profile 10 extends from the tread 1, via the shoulder region of the tire, along the side wall region and has two end sections 10a, 10b, which externally overlap the adjoining components.", "End section 10a overlaps the tread edge region, and end section 10b overlaps the side wall profile 6.At least between a height h2 of 29% of the nominal side wall height of the pneumatic vehicle tire concerned and the boundary 12, situated on the carcass 8, between the wing profile 10 and the tread 1, the wing profile 10 is the only rubber component extending outside the carcass 8.The wing profiles 10 are preferably the only rubber components from a height h2 of 25% of the nominal side wall height.", "The boundary 12 is situated at a height h3 of 80% to 90% of the cross-sectional height H. Radially outside this boundary 12, end section 10a runs out along the tread 1 with a substantially continuous reduction in its thickness but does not protrude into the region of the ground contact area of the tread 1.Starting at height h2, end section 10b of the wing profile 10 extends in the direction of the bead region 2, wherein end section 10b has a decreasing thickness on the outside of the side wall profile 6 and runs out along the side wall profile 6.The radially inner end of end section 10b of the wing profile 10 is situated at a height h4 of 20% to 25% of the nominal side wall height and radially outside the edge K. The side wall profile 6 is of substantially strip-shaped configuration in cross section, is situated between the horn profile 5 and end section 10b of the wing profile 10 and likewise has two relatively narrow tapering end sections, an end section running out along end section 10b of the wing profile 10 and an end section running out between the horn profile 5 and along the protection rib 11 as far as the edge K. In each side wall region in which the wing profile 10 is the only rubber components extending outside the carcass ply 8, it has a thickness d of 1.0 mm to 3.5 mm, preferably up to 2.5 mm, in particular at least 1.5 mm and, in particular, at most 1.8 mm, at each point perpendicularly to the extent of the radial carcass 8.In this region, the thickness d of the wing profile 10 is largely constant but can also vary slightly, in particular by up to 0.2 mm.", "Tires embodied in accordance with the invention have a lower radial stiffness in the side wall regions, this being associated with a number of advantageous effects, which are mentioned at the outset.", "It is understood that the foregoing description is that of the preferred embodiments of the invention and that various changes and modifications may be made thereto without departing from the spirit and scope of the invention as defined in the appended claims.", "LIST OF REFERENCE NUMBERS 1 Tread 2 Bead region 3 Bead core 4 Apex 5 Horn profile 6 Side wall profile 6a, 6b End section 7 Belt assembly 7a, 7b Belt ply 8 Radial carcass 8a Carcass turn-up 9 Inner layer 10 Wing profile 10a, 10b End section 11 Protective rib 12 Boundary BL Base line d Thickness H Cross-sectional height h1, h2, h3, h4 Height K Edge" ] ]
Patent_15872738
[ [ "SEMICONDUCTOR DEVICE AND MANUFACTURING METHOD THEREOF", "A semiconductor device and a manufacturing method thereof are provided.", "The semiconductor device includes: a deep trench in a substrate; a sidewall insulating film on a side surface of the deep trench; an interlayer insulating film on the sidewall insulating film; and an air gap in the interlayer insulating film." ], [ "1.A semiconductor device comprising: a substrate; a second conductivity type buried layer disposed in the substrate; a second conductivity type low dopant density well region disposed on the second conductivity type buried layer; high dopant density well regions of a second conductivity type disposed at left and right sides of the second conductivity type low dopant density well region and disposed on the second conductivity type buried layer, wherein each of the high dopant density well regions has a dopant density higher than that of the second conductivity type low dopant density well region, and the high dopant density well regions are in direct contact with the second conductivity type low dopant density well region and the second conductivity type buried layer; a first conductivity type body region in the second conductivity type low dopant density well region; a second conductivity type source region in direct contact with the first conductivity body region; a first gate electrode and a second gate electrode on the substrate, wherein both the first and second gate electrodes overlap with the first conductivity type body region; and a deep trench in the substrate.", "2.The semiconductor device according to claim 1, further comprising: a sidewall insulating film on a side surface of the deep trench; an interlayer insulating film on the sidewall insulating film, wherein the interlayer insulating film extends to a bottom of the deep trench.", "3.The semiconductor device according to claim 2, wherein the sidewall insulating film includes a first sidewall insulating film and a second sidewall insulating film, and the second sidewall insulating film is formed on the first sidewall insulating film and in direct contact with the first sidewall insulating film.", "4.The semiconductor device according to claim 2, wherein the sidewall insulating film comprises a HLD film, a TEOS film, a SOG film or a BPSG film, and the interlayer insulating film comprises a BPSG film.", "5.The semiconductor device according to claim 2, wherein the sidewall insulation film contacts a thermal oxide film formed on the deep trench.", "6.The semiconductor device according to claim 1, further comprising: a second conductivity type first well region and a second conductivity type second well region in the substrate; a second conductivity type first drain region in the second conductivity type first well region; a second conductivity type second drain region in the second conductivity type second well region; and a first conductivity type contact region in the first conductivity type body region.", "7.The semiconductor device according to claim 6, further comprising: an isolation region formed between the first conductivity type contact region and the deep trench.", "8.The semiconductor device according to claim 7, wherein the isolation region comprises a local oxidation of silicon (LOCOS) or a shallow trench.", "9.The semiconductor device according to claim 6, further comprising: a protection layer comprising an insulating film and an etching stopper film formed over the substrate, the insulating film and the etching stopper film comprising an oxide or a nitride.", "10.The semiconductor device according to claim 6, wherein a depth of the deep trench is greater than a depth of the first well region or the second well region.", "11.The semiconductor device according to claim 1, further comprising a channel stop implantation region at a bottom of the deep trench, wherein the deep trench is tapered in shape so that an upper end of the deep trench has a greater width than a lower end of the deep trench.", "12.The semiconductor device according to claim 1, wherein the first conductivity body region is formed between the first gate electrode and the second gate electrode, and wherein the first conductivity type body region is in direct contact with the second conductivity type low dopant density well region.", "13.The semiconductor device according to claim 1, wherein the first conductivity body region is spaced apart from the second conductivity type buried layer via the second conductivity type low dopant density well region.", "14.The semiconductor device according to claim 1, further comprising: a second conductivity type first well region and a second conductivity type second well region in the substrate, wherein the second conductivity type low dopant density well region is disposed between the second conductivity type first well region and the second conductivity type second well region.", "15.A semiconductor device comprising: a substrate; a second conductivity type buried layer disposed in the substrate; a second conductivity type low dopant density well region disposed on the second conductivity type buried layer; high dopant density well regions of a second conductivity type disposed at left and right sides of the second conductivity type low dopant density well region and disposed on the second conductivity type buried layer, wherein the second conductivity type low dopant density well region has a dopant density lower than that of the high dopant density well regions which are in direct contact with the low dopant density well region and the second conductivity type buried layer; a gate electrode disposed on the second conductivity type low dopant density well region; field oxide regions on the second conductivity type low dopant density well region and high dopant density well regions; a deep trench disposed adjacent to at least one of the field oxide regions and between two of the field oxide regions; a sidewall insulating film disposed on a side surface of the deep trench; an interlayer insulating film formed in the deep trench region and on the gate electrode; and an air gap within the deep trench, wherein the air gap has a sharp pointed cross-sectional shape toward a bottom of the deep trench.", "16.The semiconductor device according to claim 15, wherein the sidewall insulating film contacts a thermal oxide film formed on the deep trench.", "17.A semiconductor device comprising: a substrate of a first conductivity type; a second conductivity type buried layer disposed in the substrate; a second conductivity type low dopant density well region disposed on the second conductivity type buried layer, and high dopant density well regions of a second conductivity type disposed at left and right sides of the second conductivity type low dopant density well region, wherein each of the high dopant density well regions has a dopant density higher than that of the second conductivity type low dopant density well region, and the high dopant density well regions are in direct contact with the second conductivity type low dopant density well region and the second conductivity type buried layer; a body region in the second conductivity type low dopant density well region; a source region in direct contact with the body region, wherein the body region has a first conductivity type and the source region has a second conductivity type; a gate electrode on the substrate, wherein the gate electrode overlaps with the body region; and a deep trench in the substrate, wherein the deep trench is in direct contact with the high dopant density well regions and the second conductivity type buried layer.", "18.The semiconductor device according to claim 17, further comprising: a sidewall insulating film on a side surface of the deep trench; and a second conductivity type first well region and a second conductivity type second well region in the substrate, wherein sidewall insulating film contacts a thermal oxide film formed on the deep trench.", "19.The semiconductor device according to claim 18, wherein a depth of the deep trench is greater than a depth of the first well region or the second well region.", "20.The semiconductor device according to claim 18, wherein the sidewall insulating film includes a first sidewall insulating film and a second sidewall insulating film, and the second sidewall insulating film is formed on the first sidewall insulating film and in direct contact with the first sidewall insulating film." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>In one general aspect, there is provided a semiconductor device, comprising: a substrate, a second conductivity type buried layer disposed in the substrate, a second conductivity type low dopant density well region disposed on the second conductivity type buried layer, high dopant density well regions of a second conductivity type disposed at left and right sides of the second conductivity type low dopant density well region and disposed on the second conductivity type buried layer, wherein each of the high dopant density well regions has a dopant density higher than that of the second conductivity type low dopant density well region, and the high dopant density well regions are in direct contact with the second conductivity type low dopant density well region and the second conductivity type buried layer, a first conductivity type body region in the second conductivity type low dopant density well region; a second conductivity type source region in direct contact with the first conductivity body region, a first gate electrode and a second gate electrode on the substrate, a deep trench in the substrate, a sidewall insulating film on a side surface of the deep trench, and an interlayer insulating film on the sidewall insulating film, wherein both the first and second gate electrodes overlap with the first conductivity type body region.", "The general aspect of the semiconductor device may further include: a well region in the substrate; a body region and a drain region in the well region; and a gate electrode region on the substrate.", "The general aspect of the semiconductor device may further include a shallow trench formed between the drain region and the deep trench.", "The shallow trench may be a LOCOS trench, and the deep trench may be a DTI structure.", "The general aspect of the semiconductor device may further include: an insulating film on the substrate; and a hard mask film on the insulating film, in which the interlayer insulating film is formed on the hard mask film.", "A depth of the deep trench may be greater than a depth of the well region.", "The sidewall insulating film may include a first sidewall insulating film and a second sidewall insulating film.", "A height of the sidewall insulating film may be greater than a height of the gate electrode region, and may be equal to a height of the hard mask film.", "The interlayer insulating film may extend to a bottom of the deep trench.", "The sidewall insulating film may include a HLD film, a TEOS film, a SOG film or a BPSG film, and the interlayer insulating film may include a BPSG film.", "An upper end of the air gap may be located lower than an upper surface of the substrate.", "An upper end of the air gap may be located less than or equal to 0.5 μm below an upper surface of the substrate.", "A total thickness of the sidewall insulating film formed within the deep trench may be in a range of 1% to 70% of a width of an upper end of the deep trench.", "A total thickness of the sidewall insulating film and the interlayer insulating film formed within the deep trench may be in a range of 1% to 80% of a width of an upper end of the deep trench.", "The general aspect of the semiconductor device may further include: a support formed between the air gap and another air gap adjacent to the air gap.", "In another general aspect, there is provided a semiconductor device comprising: a substrate, a second conductivity type buried layer disposed in the substrate, a second conductivity type low dopant density well region disposed on the second conductivity type buried layer, high dopant density well regions of a second conductivity type disposed at left and right sides of the second conductivity type low dopant density well region and disposed on the second conductivity type buried layer, wherein the second conductivity type low dopant density well region has a dopant density lower than that of the high dopant density well regions which are in direct contact with the low dopant density well region and the second conductivity type buried layer, a gate electrode disposed on the second conductivity type low dopant density well region, field oxide regions on the second conductivity type low dopant density well region and high dopant density well regions, a deep trench disposed adjacent to at least one of the field oxide regions and between two of the field oxide regions, a sidewall insulating film disposed on a side surface of the deep trench, an interlayer insulating film formed in the deep trench region and on the gate electrode, and an air gap within the deep trench, wherein the air gap has a sharp pointed cross-sectional shape toward a bottom of the deep trench.", "The air gap may be located within the trench, and an upper end of the air gap may be formed at a position lower than an upper surface of the substrate.", "Throughout the drawings and the detailed description, unless otherwise described, the same drawing reference numerals will be understood to refer to the same elements, features, and structures.", "The relative size and depiction of these elements may be exaggerated for clarity, illustration, and convenience." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a Continuation of U.S. patent application Ser.", "No.", "14/067,335 filed on Oct. 30, 2013, which claims benefit under 35 U.S.C.", "§ 119(a) of Korean Patent Application 10-2013-0034805 filed on Mar.", "29, 2013, in the Korean Intellectual Property Office, the entire disclosures of which are incorporated herein by reference for all purpose.", "BACKGROUND 1.Field The following description relates to a semiconductor device and a method of manufacturing the same, and to a semiconductor device manufactured by performing a Deep Trench Isolation (DTI) process on a semiconductor substrate after device structures such as a source, a drain, and a gate are formed on the semiconductor substrate by a silicide process and a method of manufacturing such a semiconductor device.", "2.Description of Related Art The development of electronic technology resulted in an increased demand for compact multi-functional electronic devices.", "For this reason, System on Chip (SoC) technology emerged.", "System on chip technology refers to a technology for implementing a single system that integrates a plurality of devices into a single chip.", "With the recent development of MEMS (Micro-Electro-Mechanical System) technology and NEMS (Nano-Electro-Mechanical System) technology, attempts to implement various devices as a single chip have taken place.", "However, when a plurality of devices is integrated into a single substrate, interference is prone to occur between the devices.", "For instance, heat generated in driving of one device may transfer to another device through the substrate, and the heat may influence an operation of the second device.", "Thus, the interference between the devices may result in malfunction of the overall product.", "In order to prevent the occurrence of malfunctions, a device isolation structure may be utilized to electrically isolate each of the devices on the single substrate from other devices.", "Examples of technologies used for forming device isolation structures include a local oxidation of silicon (LOCOS) process, a trench isolation process and the like.", "The LOCOS process is an isolation method that involves masking a surface of a substrate with a relatively hard material such that a silicon nitride layer, and thermally growing a thick oxide layer in an opening of a mask.", "The trench isolation process is a method that involves forming a trench having an appropriate depth in a silicon substrate and filling the inside of the trench with an insulating film to electrically isolate devices from each other.", "Another kind of trench isolation process is the Deep Trench Isolation (DTI) process used for isolating wells.", "Among the various technologies for forming device isolation structures, the deep trench isolation process is often applied to satisfy the requirement of high-integration of semiconductor devices.", "By using a deep trench isolation structure (DTI structure), it is possible to reduce a pitch of the transistor and to improve latch-up leading to a decrease in device characteristics due to current leakage and overcurrent.", "As a result, the DTI structure has characteristics suitable for reducing the size of chips and for improving the performance of devices.", "In manufacturing processes for producing semiconductor devices in which a DTI structure is formed, the DTI process is generally performed before a process of forming a LOCOS or a shallow trench (STI) in the semiconductor substrate.", "Incidentally, in manufacturing a semiconductor device such as a Lateral Double-diffused Metal Oxide Semiconductor (LDMOS) used as a high voltage power device, when the DTI process is performed before the LOCOS process or a process of forming a gate electrode, various issues may occur.", "For example, in the manufacturing process of the semiconductor device, a plurality of annealing processes are performed as processes subsequent to the DTI process.", "Accordingly, the thermal stress resulting from the processes may affect a trench structure formed in the semiconductor substrate by the DTI process.", "In order to reduce the problems resulting from the thermal stress, many additional processes for releasing the thermal stress may be performed, and the additional processes may in turn impose other challenges or problems.", "Patent Document: Korean Laid-Open Publication No.", "2011-0030356 SUMMARY In one general aspect, there is provided a semiconductor device, comprising: a substrate, a second conductivity type buried layer disposed in the substrate, a second conductivity type low dopant density well region disposed on the second conductivity type buried layer, high dopant density well regions of a second conductivity type disposed at left and right sides of the second conductivity type low dopant density well region and disposed on the second conductivity type buried layer, wherein each of the high dopant density well regions has a dopant density higher than that of the second conductivity type low dopant density well region, and the high dopant density well regions are in direct contact with the second conductivity type low dopant density well region and the second conductivity type buried layer, a first conductivity type body region in the second conductivity type low dopant density well region; a second conductivity type source region in direct contact with the first conductivity body region, a first gate electrode and a second gate electrode on the substrate, a deep trench in the substrate, a sidewall insulating film on a side surface of the deep trench, and an interlayer insulating film on the sidewall insulating film, wherein both the first and second gate electrodes overlap with the first conductivity type body region.", "The general aspect of the semiconductor device may further include: a well region in the substrate; a body region and a drain region in the well region; and a gate electrode region on the substrate.", "The general aspect of the semiconductor device may further include a shallow trench formed between the drain region and the deep trench.", "The shallow trench may be a LOCOS trench, and the deep trench may be a DTI structure.", "The general aspect of the semiconductor device may further include: an insulating film on the substrate; and a hard mask film on the insulating film, in which the interlayer insulating film is formed on the hard mask film.", "A depth of the deep trench may be greater than a depth of the well region.", "The sidewall insulating film may include a first sidewall insulating film and a second sidewall insulating film.", "A height of the sidewall insulating film may be greater than a height of the gate electrode region, and may be equal to a height of the hard mask film.", "The interlayer insulating film may extend to a bottom of the deep trench.", "The sidewall insulating film may include a HLD film, a TEOS film, a SOG film or a BPSG film, and the interlayer insulating film may include a BPSG film.", "An upper end of the air gap may be located lower than an upper surface of the substrate.", "An upper end of the air gap may be located less than or equal to 0.5 μm below an upper surface of the substrate.", "A total thickness of the sidewall insulating film formed within the deep trench may be in a range of 1% to 70% of a width of an upper end of the deep trench.", "A total thickness of the sidewall insulating film and the interlayer insulating film formed within the deep trench may be in a range of 1% to 80% of a width of an upper end of the deep trench.", "The general aspect of the semiconductor device may further include: a support formed between the air gap and another air gap adjacent to the air gap.", "In another general aspect, there is provided a semiconductor device comprising: a substrate, a second conductivity type buried layer disposed in the substrate, a second conductivity type low dopant density well region disposed on the second conductivity type buried layer, high dopant density well regions of a second conductivity type disposed at left and right sides of the second conductivity type low dopant density well region and disposed on the second conductivity type buried layer, wherein the second conductivity type low dopant density well region has a dopant density lower than that of the high dopant density well regions which are in direct contact with the low dopant density well region and the second conductivity type buried layer, a gate electrode disposed on the second conductivity type low dopant density well region, field oxide regions on the second conductivity type low dopant density well region and high dopant density well regions, a deep trench disposed adjacent to at least one of the field oxide regions and between two of the field oxide regions, a sidewall insulating film disposed on a side surface of the deep trench, an interlayer insulating film formed in the deep trench region and on the gate electrode, and an air gap within the deep trench, wherein the air gap has a sharp pointed cross-sectional shape toward a bottom of the deep trench.", "The air gap may be located within the trench, and an upper end of the air gap may be formed at a position lower than an upper surface of the substrate.", "Throughout the drawings and the detailed description, unless otherwise described, the same drawing reference numerals will be understood to refer to the same elements, features, and structures.", "The relative size and depiction of these elements may be exaggerated for clarity, illustration, and convenience.", "BRIEF DESCRIPTION OF THE DRAWINGS FIGS.", "1 to 12B are cross-sectional views for describing an example of a method for fabricating a semiconductor device according to the present disclosure.", "FIG.", "13 is a photograph depicting an air gap formed after the process is finished in an example of a semiconductor device formed according to the present disclosure.", "FIG.", "14 is a photograph depicting an example of a semiconductor substrate in which two semiconductor devices are provided with air gaps 200 in a horizontal direction.", "FIG.", "15 is an enlarged view of an example of a trench region illustrated in FIGS.", "12A and 12B.", "FIG.", "16 is an enlarged view of a semiconductor substrate in which two semiconductor devices are brought into contact with each other, as illustrated in FIG.", "12B.", "FIG.", "17 is a cumulative curve illustrating current leakage characteristics of an example of a semiconductor device according to the present disclosure.", "Throughout the drawings and the detailed description, unless otherwise described, the same drawing reference numerals will be understood to refer to the same elements, features, and structures.", "The relative size and depiction of these elements may be exaggerated for clarity, illustration, and convenience.", "DETAILED DESCRIPTION The following detailed description is provided to assist the reader in gaining a comprehensive understanding of the methods, apparatuses, and/or systems described herein.", "However, various changes, modifications, and equivalents of the systems, apparatuses and/or methods described herein will be apparent to one of ordinary skill in the art.", "Also, descriptions of functions and constructions that are well known to one of ordinary skill in the art may be omitted for increased clarity and conciseness.", "Throughout the drawings and the detailed description, the same reference numerals refer to the same elements.", "The drawings may not be to scale, and the relative size, proportions, and depiction of elements in the drawings may be exaggerated for clarity, illustration, and convenience.", "The features described herein may be embodied in different forms, and are not to be construed as being limited to the examples described herein.", "Rather, the examples described herein have been provided so that this disclosure will be thorough and complete, and will convey the full scope of the disclosure to one of ordinary skill in the art.", "Unless indicated otherwise, a statement that a first layer is “on” a second layer or a substrate is to be interpreted as covering both a case where the first layer is directly contacts the second layer or the substrate, and a case where one or more other layers are disposed between the first layer and the second layer or the substrate.", "The spatially-relative expressions such as “below”, “beneath”, “lower”, “above”, “upper”, and the like may be used to conveniently describe relationships of one device or elements with other devices or among elements.", "The spatially-relative expressions should be understood as encompassing the direction illustrated in the drawings, added with other directions of the device in use or operation.", "Further, the device may be oriented to other directions and accordingly, the interpretation of the spatially-relative expressions is based on the orientation.", "The expression such as “first conductivity type” and “second conductivity type” as used herein may refer to the conductivity types such as N or P types which are opposed to each other, and an example explained and exemplified herein encompasses complementary examples thereof.", "According to the present disclosure, there is provided an example of a manufacturing process in which a DTI process is performed on a semiconductor device.", "The DTI process for isolating devices may be performed immediately after a gate electrode or a silicide structure is formed during the manufacturing process of the semiconductor device.", "Hereinafter, a semiconductor device and a manufacturing method of producing the semiconductor device according to an example of the present disclosure will be described with reference to FIGS.", "1 to 12.FIGS.", "1 to 12 are cross-sectional views for describing an example of a manufacturing method of a semiconductor device according to the present disclosure.", "In the example of the manufacturing method, the process of forming an N-type LDMOS (Lateral Double diffused MOS) device will be described as an example of a lateral DMOS; however, the present disclosure is not limited thereto.", "FIG.", "1 is a cross-sectional view of a semiconductor device before the DTI process is performed in accordance with an example of a manufacturing method according to the present disclosure.", "The illustrated cross-sectional view is a cross-sectional view of an NLDMOS device as an integrated power device constituting a BCD (Bipolar-CMOS-DMOS) device.", "Referring to FIG.", "1, the NLDMOS device is in a state in which device structures such as a source, a drain, and a gate are already formed.", "A structure of the NLDMOS device will be briefly described below.", "In the NLDMOS device, an n-type buried layer (NBL) 112 is formed inside a p-type silicon substrate 110 as a high doped region.", "A p-epitaxial layer 114 is formed on the buried layer 112, and high density n-well (HDNW) regions 116 are formed at left and right sides of the p-epitaxial layer 114.As explained later, the p-epitaxial layer 114 may be changed to an n-type region after the process of forming a DTI structure.", "The p-epitaxial layer 114 is a region in which impurities doped into the high density n-well (HDNW) regions 116 are diffused through an annealing process during the manufacture process of the semiconductor device.", "After the conversion into an n-type region, this region is an n-well region (i.e., a low density n-well region) doped at a density relatively lower than those of the high density n-well (HDNW) regions 116.The low density n-well region is formed to have a depth shallower than that of a trench to be described below.", "Gate electrodes 126 are formed above the silicon substrate 110 with a gate oxidation film 125 disposed therebetween for insulation.", "A p-body region 118 in which a p+ contact region 118a and n+ source regions 118b are provided is formed in a predetermined region of the p-epitaxial layer 114 or the low density n-well region.", "High density n+ drain regions 122 surrounded by low concentration doped regions (NW) 120 are formed in the high density n-well (HDNW) regions 116.In this example, the p-body region 118 may be initially formed on the p-epitaxial layer 114 or the low density n-well region.", "The p-body region 118 may be subsequently formed in the p-epitaxial layer 114 before the semiconductor device is manufactured and/or formed in the low density n-well region after the annealing processes are all finished.", "Thus, the p+ contact region 118a and n+ source regions 118b are subsequently disposed within the p-body region.", "Referring to FIG.", "1, a silicide layer 124 is formed on the p-body region 118 and on the gate electrodes 126.The silicide layer 124 includes, for example, TiSi2 or CoSi2.A LOCOS trench or a shallow trench (STI) region 128 is formed in order to reduce an electric field between the gate electrode 126 and the n+drain region 122.In an example of a method for manufacturing a semiconductor device, the process of forming the trench starts after the silicide layer 124 is formed.", "Referring to FIG.", "1, an insulating film 130 is deposited on the entire surface of the p-type silicon substrate 110, including the top surfaces of the p-body region 118, the n+ drain regions 122, and the gate electrodes 126.The insulating film 13 may be deposited by a low-pressure chemical vapor deposition (LPCVD) method or a high temperature low pressure deposition (HLD) method.", "In this example, the insulating film 130 is deposited to have a thickness of about 1,000 angstroms to about 2,000 angstroms.", "Examples of the insulation film 130 may include an oxidation film or a nitride film.", "The nitride film may more effectively serve as an etching stopper film so as not to expose the gate electrode 126.Subsequently, referring to FIG.", "2, a Tetra Ethyl Ortho Silicate (TEOS) layer 140 is deposited on the insulation film 130 as a silicon oxidation film.", "The TEOS layer 140 may have a thickness of about 5,000 angstroms to about 15,000 angstroms.", "The TEOS layer 140 may serve as a hard mask used as a blocking layer in a subsequent trench forming process.", "Referring to FIG.", "3, after the TEOS layer 140 is formed as the hard mask, a patterned photo resist 150 is coated on the TEOS layer 140.The photo resist 150 is used to remove the TEOS layer 140 as oxides for the hard mask by a photo-lithography method.", "Further, the photo resist is patterned such that regions corresponding to regions of the p-type silicon substrate 110 where trenches are formed are not coated.", "Otherwise, a separate process for patterning the photo resist 150 may be performed.", "Thereafter, referring to FIG.", "4, the TEOS layer 140 is etched by using the photo resist 150 as a mask.", "Then, parts of the TEOS layer 140 corresponding to the uncoated regions of the photo resist 150 are etched to a surface of the p-type silicon substrate 110.As a result, portions of top surfaces of the high density n-well (HDNW) regions 116 are partially exposed.", "For instance, referring to FIG.", "4, the TEOS layer 140 is etched to correspond to the pattern of the photo resist 150.In FIG.", "4, the portions of the TEOS layer 140 that are etched is marked with reference label “A.” When a part of the TEOS layer 140 is etched, the photo resist 150, which has been used as the mask, may be removed.", "The photo resist 150 may be removed by a dry ashing process and a cleaning process.", "FIG.", "5 illustrates a state in which a part of the TEOS layer 140 is etched and the photo resist 150 is removed.", "Subsequently, a process of forming a trench in the p-type silicon substrate 110 is performed.", "Referring to FIG.", "6, the p-type silicon substrate 110 is etched, and trench regions B are formed.", "Here, the trench regions B are formed in the p-type silicon substrate 110 by a dry etching method, and are formed to correspond to the etched regions A of the TEOS layer 140.An etching gas used in the dry etching method does not influence the TEOS layer 140 but etches only the p-type silicon substrate 110.In this example, a side surface of the trench region B is not at a right angle with the upper surface of the semiconductor substrate; rather, the side surface of the trench region B is a slightly inclined surface.", "The inclined surface results due to the weakening of the intensity of the etching gas along the depth of the trench.", "In one example, the trench formed by such an etching method has a depth of about 2 μm to about 30 μm.", "In another example, the trench region B formed in the p-type silicon substrate 110 has a depth of about one and a half to about three times a depth of the p-epitaxial layer 114 formed in the p-type silicon substrate 110.Referring to FIG.", "6, when the etching process for forming the trench region B is performed, polymers are also formed.", "Since such polymers cause a decrease in performance of the semiconductor device, the polymers need to be removed.", "Accordingly, after the etching process is finished, it is necessary to perform a post cleaning process for removing the polymers.", "A cleaning solution that contains a Buffered Oxide Etchant (BOE) is used as a cleaning solution during the post cleaning process.", "Also, after the post cleaning process is completed, an oxidation process may be performed.", "The oxidation process may be performed to remove various defects generated on a surface of the p-type silicon substrate 110 during the etching process performed to form the trench region B.", "As described above, when the trench region B is formed in the p-type silicon substrate 110, a dry oxidation process is performed to form a thermal oxide film 160 on a boundary of the trench region B as illustrated in FIG.", "7.This thermal oxide film is formed in order to block electric leaking components occurring along the boundary of the trench region B.", "In addition, channel stop implantation is performed on a bottom surface 162 of the trench region B to block leakage current to prevent the formation of channels other than predetermined channels.", "Referring to FIGS.", "12A and 12B, a gap-fill process is subsequently performed to form a void or an air gap 200 within the trench region B.", "The air gap serves as an insulating member.", "Accordingly, when the air gap is formed, it is possible to insulate devices formed in the p-type silicon substrate 110 in a horizontal direction in addition to a trench structure to be electrically stabilized.", "A height of the air gap formed within the trench region B contributes significantly to the ability of the trench to prevent interferences.", "According to one example, an upper end of the air gap is located at a position lower than the surface of the p-type silicon substrate 110.If the height of the air gap is higher than the surface of the silicon substrate 110, the inside of the air gap may be exposed to the outside in a deposition process of a HLD oxidation film as oxides and an etch-back process of removing a part of the deposited HLD oxidation film, which will be described below.", "Thus, the inside of the air gap may be contaminated by foreign substances, so that a decrease in performance of the semiconductor device may result.", "Hereinafter, a process for forming the air gap will be described in detail.", "In this example, the deposition process and the etch-back process of the HLD oxidation film, which form a sidewall insulating film, are repeatedly performed twice.", "However, the present disclosure is not limited thereto.", "In other examples, the deposition process and the etch-back process of the HLD oxidation film may be performed one time as long as the air gap is formed at a position lower than the top surface of the silicon substrate.", "Alternatively, the deposition process and the etch-back process may be performed again, for the third time, if the air gap is not appropriately formed even though the deposition process and the etch-back process are performed twice.", "However, in this example, the deposition process and the etch-back process may be performed twice in order to simplify the manufacturing process.", "Accordingly, the deposited HLD oxidation film needs to have an appropriate thickness in consideration of the subsequent process.", "Referring to FIG.", "8, the deposition process of the HLD oxidation film is performed to form a first sidewall insulating film of the air gap.", "Hereinafter, this process is referred to as a “first DTI HLD deposition process.” During the first DTI HLD deposition process, a HLD oxidation film 170 is deposited on a top surface of the p-type silicon substrate 110 and on the side surface of the trench region B.", "The HLD oxidation film 170 includes an oxidation film material.", "During the first DTI HLD depositing process, the HLD oxidation film 170 needs to be deposited to have an appropriate thickness such that after the subsequent two etch-back processes and one deposition process, the air gap is formed at a position lower than the surface of the p-type silicon substrate 110.The thickness to be used may be determined based on an experiment result value obtained through multiple experiments.", "Further, referring to FIG.", "8, the HLD oxidation film 170 is formed with a greater height than the gate electrode 126, and is formed to be approximately equal or similar to the TEOS layer 140 in height.", "The TEOS layer may serve as a hard mask.", "In one example, a deposition temperature of the HLD oxidation film 170 used as a gap-fill material for the trench region B may range between about 550° C. to about 750° C. In the event it is necessary to avoid high deposition temperature during the manufacturing process, a material such as TEOS, SOG, or BPSG that have a low deposition temperature may be deposited instead of the HLD oxidation film 170.The deposition temperature of the TEOS is approximately 400° C. lower than the HLD oxidation film 170.The HLD oxidation film 170 is deposited by a HLD method.", "The HLD method results in the formation of a LPCVD oxidation film, and the thickness of the HLD oxidation film 170 deposited on the top surface of the p-type silicon substrate 110 is slightly different from the thickness of the HLD oxidation film 170 deposited on the side surface of the trench region B.", "Accordingly, referring to FIG.", "8, an edge C of an upper edge of the side surface of the trench region B and the top surface of the p-type silicon substrate 110 are formed in a thick overhang shape by the different thicknesses of the HLD oxidation films 170 along the depth of the trench region B.", "That is, the width of the void within the trench region B may be broader at the middle portion of the trench region B than at the upper portion of the trench region B.", "After the first DTI HLD deposition process is finished, a first etch-back process of removing a part of the HLD oxidation film 170 is performed.", "The first etch-back process is performed by the dry etching method.", "Referring to FIG.", "9, during the first etch-back process, the HLD oxidation film 170 formed on the p-type silicon substrate 110 and a portion of the TEOS layer 140 are removed.", "In other words, as illustrated in FIG.", "9, the TEOS layer 140 is removed until a part of the oxidation film or the nitride film 130 formed on the gate electrode 126 is exposed.", "In this example, the etch-back process is performed with care so as not to damage a structure of the gate electrode 126.Referring back to FIG.", "9, a certain amount of HLD oxidation film 170 formed on the side surface of the trench region B remains after the first etch-back process.", "After the completion of the first DTI HLD deposition process and the first etch-back process, as illustrated in FIG.", "9, a distance between the upper edges of the trench region B is enlarged.", "Thus, it is difficult to form an air gap of appropriate thickness within the p-type silicon substrate 110.For this reason, as illustrated in FIG.", "10, a second DTI HLD deposition process is performed.", "The second DTI deposition process is performed in a similar manner to the first DTI HLD deposition process.", "FIG.", "10 illustrates a state of the semiconductor device after the second DTI HLD deposition process is performed.", "Referring to FIG.", "10, a distance between the two upper edges of the trench region B decreases due to the second DTI deposition process, and the upper edges D of the trench region B again have an overhang shape.", "In this example, the distance between the side walls of the trench region B is greater in a middle region of the trench region B than the distance between the two upper edges D of the trench region B.", "Referring to FIG.", "11, subsequently, a second etch-back process is performed to remove the HLD oxidation film 170.The second etch-back process needs to be performed so as not to damage structures of the device such as the gate electrode 126.The structure that results after the second etch-back process is illustrated in FIG.", "11.As illustrated in FIG.", "11, the overhang shape of the trench B is preserved.", "In addition, a distance between the upper edges of the trench region B is smaller after the second etch-back process than the distance between the upper edges after the first etch-back process.", "As demonstrated by this example, in order to form the air gap in the trench region B at a position lower than the surface of the p-type silicon substrate 110, the deposition process and the etch-back process of the HLD oxidation film may be performed twice.", "In this example, performing the deposition process and the etch-back process twice as illustrated facilitate forming the overhang structure along the edges of the upper portions of the trench region B.", "For instance, in this example, the overhang structure found in the final product is formed during the second deposition process of the HLD oxidation film.", "Although the HLD oxidation film 170 is largely etched during the etch-back process to decrease the height of the air gap, the etch-back process is performed so as not to influence structures of the device such as the gate electrode 126 as described above.", "Lastly, after the deposition process and the etch-back process of the HLD oxidation film are performed twice, a BPSG (boron phosphorus silicate glass) material 180 used as an interlayer insulating material (ILD) may be deposited on the entire area of the p-type silicon substrate 110 and may seal the opening along the upper edges of the trench region B in an upper portion of the trench region B, forming an air gap within a middle region of the trench region B.", "Referring to FIGS.", "12A and 12B, in one example, the BPSG 180 is deposited within the trench and fills a portion of the trench.", "A film of the BPSG 180 used during the process needs to have flow properties that are more favorable than the HLD oxidation film during the high-temperature annealing process.", "With suitable flow properties, the BPSG may pass through a narrow entrance between the upper edges of the trench region B.", "As a result, the BPSG may be deposited on the HLD oxidation film formed on the side surfaces of the trench.", "In addition, some of the BPSG may be deposited on the lower portion of the trench.", "Referring to FIG.", "12A, after the gap-fill process is performed, the BPSG 180 is deposited over the entire surface of the p-type silicon substrate 110 as an interlayer insulating film.", "The BPSG 180 also seals the opening to the trench region B, so that the air gap 200 is formed within the trench region B.", "FIG.", "12B illustrates two semiconductor devices that are arranged in repetition in a horizontal direction.", "Further, a support is formed between the two semiconductor devices.", "The support will be further described below with reference to FIG.", "16.Meanwhile, referring to FIGS.", "13 and 14, an air gap formed in a silicon substrate through the example of manufacturing process described above is illustrated in photographs.", "FIG.", "13 depicts an air gap formed after the trench producing process described above.", "FIG.", "13(a) demonstrate the overhang shape of the trench formed by the above described process.", "As depicted in FIG.", "13(b), the air gap is formed at a position lower than a surface of the silicon substrate.", "According to one example, an upper edge of the air gap may be formed at a position that is less than or equal to 0.5 μm upwards from a surface of the semiconductor substrate.", "FIG.", "14 depicts a semiconductor substrate in which two semiconductor devices are formed in a horizontal direction.", "A plurality of air gaps 200 is disposed between the semiconductor devices.", "With such a configuration, it is possible to effectively prevent interference between the semiconductor devices by the air gaps.", "FIG.", "15 illustrates an enlarged cross-sectional view of the trench region of the semiconductor device illustrated in FIGS.", "12A and 12B.", "FIG.", "15 further describes various dimensions of the trench region B.", "Referring to FIG.", "15, in one example, a critical diameter D1 or a width of the upper end portion of the trench region B is in a range of 1.2 μm to 3.0 μm, and a thickness (D2+D3) of the HLD oxidation film 170 formed on the side surface of the air gap 200 in a middle portion of the trench region B is in a range of 0.30 μm to 0.8 μm.", "In one example, the HLD oxidation film 170 is formed to have a total thickness (D2+D3) in a range of about 1% to about 70% of the width or the critical diameter D1.By setting the thickness in this range, it is possible to minimize stress and to easily form the air gap 200 in the trench region B.", "When the thickness of the HLD oxidation film 170 is thinner than 1% of the width of the upper end of the trench, it is difficult to easily form the air gap 200.Further, when the thickness of the HLD oxidation 170 is thicker than 70% of the width of the upper end of the trench, stress may occur on the silicon substrate due to a difference in coefficients of thermal expansion between the HLD oxidation film 170 and the n-well region 116 of the silicon substrate.", "In addition, the HLD oxidation film 170 and the BPSG 180 may be formed to have the total thickness in a range of about 1% to about 80% of the width of the upper end of the trench.", "With the provided dimension, it is possible to facilitate the formation of the air gap and reduce the occurrence of stress.", "FIG.", "16 is an enlarged view of a portion of the semiconductor substrate of FIG.", "12B in which the two semiconductor devices are provided in contact with each other.", "Referring to FIG.", "16, a support 210 is formed between the air gaps 200 provided around the peripheries of two adjacent semiconductor devices.", "The support 210 serves to maintain a shape of the air gap 200.In the example depicted in FIG.", "16, the support 210 has a width w of approximately 0.5 μm to approximately 3 μm.", "In a semiconductor device manufactured by the process described above, current leakage characteristics are considerably improved in comparison to the conventional semiconductor devices.", "The above conventional semiconductor devices herein refers to a semiconductor device manufactured by being formed of DTI structure before forming device structures e.g.", "a source and drain, etc.", "FIG.", "17 is a cumulative curve illustrating current leakage characteristics according to the example described above.", "The X-axis represents measuring leakage current of each device and Y-axis represents cumulative percent at each level of the leakage current level.", "For comparison, vertical dot line is inserted at leakage current level at 1 uA.", "The curve “L” corresponds to the example according to the present disclosure.", "The curve “L” shows the higher cumulative percent at 1 uA than other curves “M”, which means that the leakage current level more decreased by fabricating DTI structure after forming device structures e.g.", "a source and drain.", "It can be seen from FIG.", "17 that the current leakage characteristics are significantly improved in comparison to the conventional semiconductor devices.", "Here, the current leakage characteristics in FIG.", "17 result from one semiconductor device as illustrated in FIG.", "12A and the curves other than curve L represent values of the current leakage characteristics to the above conventional semiconductor devices.", "As stated above, in the examples of semiconductor device according to the present disclosure, by performing the DTI process after a transistor structure such as a source or a drain is formed in the semiconductor substrate, it is possible to reduce a manufacturing time and cost of the semiconductor device.", "An aspect of the present disclosure provides a semiconductor device and a manufacturing method thereof, with which it is possible to simplify a manufacturing process and to solve issues occurring in an annealing process subsequent to a DTI process by improving the manufacturing process of the semiconductor device that performs an insulating operation between devices by using a DTI structure.", "In this example, the semiconductor device may be manufactured as a final product through multiple steps of a manufacturing process, and the present disclosure provides, as an example, a semiconductor device with performance and effect equivalent to or even superior to existing semiconductor devices by improving the manufacturing process of the semiconductor device.", "There are also provided a semiconductor device and a manufacturing method thereof, with which a manufacturing process of the semiconductor device may be improved such that a deep trench isolation (DTI) process for isolating a device is performed immediately after a gate electrode or a silicide structure is formed in the manufacturing process of the semiconductor device.", "Since the process of forming a DTI structure is performed after the silicide process, it is possible to prevent various defects caused by an annealing process performed after the DTI process and to reduce the number of steps in the manufacturing process of the semiconductor device in which the DTI structure is formed.", "As a result, with this example, it is possible to reduce a manufacturing time and cost.", "Although the present disclosure has been described in connection with a number of examples, it should be understood by those skilled in the art that various changes, modifications, and equivalent examples can be made without departing from the scope and sprit of the present disclosure.", "Accordingly, the scope of the present disclosure should not be limited by these examples.", "For instance, although various examples of the present disclosure have been described with respect to an NLDMOS (Lateral Double diffused MOS) device, the present disclosure is applicable to other types of semiconductor devices, including semiconductor devices having a p-type LDMOS device and a Deep trench Isolation structure (DTI structure).", "Further, while various examples of manufacturing methods have been described in which the deposition process and the etch-back process of the HLD oxidation film are performed twice, the present disclosure is not limited thereto.", "For example, the deposition process and the etch-back process of the HLD oxidation film may be performed only one time.", "Moreover, after a DTI structure is formed, when the DTI etching process is finished, the forming process of the LPCVD oxidation film, the deposition process of the BPSG (boron phosphorus silicate glass), the etch-back process, and the deposition process of the BPSG (boron phosphorus silicate glass) may be performed instead of the gap-fill process of the trench region, so that the air-gap of the trench region may be filled.", "Examples of semiconductor devices and manufacturing methods thereof may exhibit the following effects.", "During the manufacturing process of the semiconductor device in which a DTI structure is formed, a process of forming the DTI structure that is generally performed before the existing LOCOS process, may be performed after a silicide process in which transistor structures such as a source and a drain are all formed.", "Accordingly, it is possible to prevent occurrence of various defects in a substrate or a trench structure that results during an annealing process.", "In one example, the defects of the trench structure are prevented, so that current leakage characteristics of the semiconductor device may be improved.", "Conventionally, in order to manufacture the semiconductor device to which the DTI structure is formed, an additional process is required for controlling the defects of the semiconductor substrate.", "However, with the method described in the present disclosure, by changing an order of the DTI process, it is possible to reduce the number of steps in the manufacturing process of the semiconductor device in which the DTI structure is formed.", "As a result, it is possible to reduce a manufacturing time and cost.", "For example, seventy one (71) steps are substantially required for the existing process for manufacturing the semiconductor device through the DTI step.", "However, in the present disclosure, it is possible to reduce the number of steps to be thirty (30) steps.", "While this disclosure includes specific examples, it will be apparent to one of ordinary skill in the art that various changes in form and details may be made in these examples without departing from the spirit and scope of the claims and their equivalents.", "The examples described herein are to be considered in a descriptive sense only, and not for purposes of limitation.", "Descriptions of features or aspects in each example are to be considered as being applicable to similar features or aspects in other examples.", "Suitable results may be achieved if the described techniques are performed in a different order, and/or if components in a described system, architecture, device, or circuit are combined in a different manner and/or replaced or supplemented by other components or their equivalents.", "Therefore, the scope of the disclosure is defined not by the detailed description, but by the claims and their equivalents, and all variations within the scope of the claims and their equivalents are to be construed as being included in the disclosure." ] ]
Patent_15872747
[ [ "Fabrication Method for Emissive Display with Light Management System", "A method is provided for fabricating an emissive display substrate with a light management system.", "The method provides a transparent first substrate with a top surface and forms a plurality of emissive element wells.", "The well sidewalls are formed from a light absorbing material or a light reflector material.", "In one aspect, a light blocking material film layer is formed overlying the first substrate top surface, and the emissive element sidewalls are formed in the light blocking material film layer.", "In another aspect, a transparent second substrate is formed overlying the first substrate top surface.", "Then, the emissive element wells are formed in the second substrate with via surfaces, and the light blocking material is deposited overlying the well via surfaces.", "Additionally, the light blocking material may be formed on the bottom surface of each well.", "An emissive display substrate with light management system is provided below." ], [ "1-13.", "(canceled) 14.A method for fabricating an emissive display substrate with a light management system, the method comprising: providing a transparent first substrate with a top surface; forming a transparent second substrate overlying the first substrate top surface; forming a plurality of emissive element wells in the second substrate with via surfaces; depositing a light blocking material overlying the well via surfaces: forming emissive element well sidewalls from the light blocking material; and, using a fluidic assembly process to populate the wells with emissive elements.", "15.The method of claim 14 wherein the light blocking material is selected from the group consisting of a light absorbing material and a light reflector material.", "16-18.", "(canceled) 19.The method of claim 14 wherein providing the first substrate includes providing a substrate with a first plurality of electrical interfaces formed on the top surface; and, wherein forming the emissive element wells includes etching the second substrate to expose the first plurality of electrical interfaces, forming an electrical interface on each well bottom surface.", "20.The method of claim 18 wherein forming well sidewalls from the light blocking material includes: conformally depositing the light absorbing blocking material overlying the second substrate top surface and filling the wells; patterning the light blocking material to avoid the electrical interface formed on the well bottom surface; and, etching the light absorbing blocking material to expose the electric interface on each well bottom surface.", "21.", "(canceled) 22.The method of claim 15 wherein the light absorber material is selected from a group consisting of a black polymer resin, a black photoresist, a material comprising carbon black, and a material comprising graphene oxide.", "23.The method of claim 15 wherein the light reflector material is selected from a group consisting of aluminum, titanium, silver, tin, indium, nickel, and gold.", "24.The method of claim 14 wherein forming the emissive element wells includes forming emissive wells with sloped via surfaces; and, wherein forming emissive element well sidewalls includes forming sloped emissive element well sidewalls 25.", "(canceled) 26.A method for managing the direction of light emitted from an emissive display substrate, the method comprising: providing a transparent substrate and a plurality of emissive element wells; forming light blocking material well sidewalls; populating the wells with emissive elements using a fluidic assembly process; and, in response to the light blocking material sidewalls, preventing the propagation of light between adjacent wells.", "27.A method for fabricating an emissive display substrate with a light management system, the method comprising: providing a transparent first substrate with a top surface; forming a light blocking material film layer overlying the first substrate top surface; forming a plurality of emissive element wells in the light blocking material film layer; and, using a fluidic assembly process, populating the emissive element wells with emissive elements.", "28.The method of claim 27 wherein the light blocking material is selected from the group consisting of a light absorbing material and a light reflector material.", "29.The method of claim 27 wherein forming the plurality of emissive element wells in the light blocking material film layer includes forming the light blocking material on a bottom surface of each well.", "30.The method of claim 29 wherein providing the first substrate includes providing a substrate with a plurality of electrical interfaces formed on the top surface; the method further comprising: patterning the light blocking material to avoid the electrical interface formed on the well bottom surface; and, etching the light blocking film layer to expose the first plurality of electrical interfaces, forming an electrical interface on each well bottom surface.", "31.The method of claim 28 wherein the light absorber material is selected from a group consisting of a black polymer resin, a black photoresist, a material comprising carbon black, and a material comprising graphene oxide.", "32.The method of claim 28 wherein the light reflector material is selected from a group consisting of aluminum, titanium, silver, tin, indium, nickel, and gold.", "33.The method of claim 27 wherein forming the emissive element wells includes forming emissive element wells with sloped via surfaces; and, wherein forming emissive element well sidewalls includes forming sloped emissive element well sidewalls 34.A method for fabricating an emissive display substrate with a light management system, the method comprising: providing a transparent first substrate with a top surface; forming emissive element wells in the first substrate with via surfaces; depositing a light blocking material overlying the well via surfaces; and, using a fluidic assembly process, populating the emissive element wells with emissive elements.", "35.The method of claim 34 wherein the light blocking material is selected from the group consisting of a light absorbing material and a light reflector material.", "36.The method of claim 34 further comprising: forming the light blocking material on a bottom surface of each well.", "37.The method of claim 34 wherein depositing the light blocking material overlying the well via surfaces includes: conformally depositing a light blocking material film layer; patterning the light blocking material to avoid an electrical interface formed on each well bottom surface; and, etching the light blocking film layer to expose the first plurality of electrical interfaces, forming an electrical interface on each well bottom surface.", "38.The method of claim 35 wherein the light absorber material is selected from a group consisting of a black polymer resin, a black photoresist, a material comprising carbon black, and a material comprising graphene oxide.", "39.The method of claim 35 wherein the light reflector material is selected from a group consisting of aluminum, titanium, silver, tin, indium, nickel, and gold.", "40.The method of claim 34 wherein forming the emissive element wells includes forming emissive element wells with sloped via surfaces; and, wherein forming emissive element well sidewalls includes forming sloped emissive element well sidewalls." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>Described herein are structural features used with direct emitting emissive elements, such as micro light emitting diodes (uLEDs), which control the directionality of light emitted.", "An emissive display may be composed of a multitude of uLED pixels; each one addressed individually.", "It is important that the direction of the light emitted by each uLED is controlled to reduce light leakage between pixels to ensure color quality and contrast.", "The light from each uLED is emitted from all surfaces including the faces and the sides and is thus emitted in directions perpendicular and parallel to the surface of the display.", "Unless controlled, the light emitted along the direction nominally parallel to a transparent display substrate surface will propagate to adjacent pixels.", "The structure features described herein are used to reflect or absorb this light.", "Reflective materials may include metals already incorporated into the backplane manufacturing, including aluminum, titanium, silver, tin, indium, nickel, gold, or other reflective metals.", "Absorptive materials may include black polymer resin and black photoresist materials containing carbon black or graphene oxide.", "Accordingly, a method is provided for fabricating an emissive display substrate with a light management system.", "The method provides a transparent first substrate with a top surface and forms a plurality of emissive element wells.", "The well sidewalls are formed from a light blocking material.", "In the simplest case, the wells are formed in the first substrate.", "As mentioned above, the light blocking material may be a light absorbing material or a light reflector material.", "In one aspect, a light blocking material film layer is formed overlying the first substrate top surface, and the emissive element sidewalls are formed in the light blocking material film layer.", "In another aspect, a transparent second substrate is formed overlying the first substrate top surface.", "Then, the emissive element wells are formed in the second substrate with via surfaces, and the light blocking material is deposited overlying the well via surfaces.", "Additionally, the light blocking material may be formed on the bottom surface of each well.", "If the first substrate includes electrical interfaces formed on the top surface, the emissive element wells formed in the second substrate are etched to expose an electrical interface formed on each well bottom surface.", "Then, the light blocking material on the well bottom surface is patterned to avoid the electrical interface formed on the well bottom surface.", "In another aspect, prior to depositing the light blocking material, a fluidic assembly process is used to populate the wells with emissive elements.", "Note, the wells can also be populated using a pick-and-place process, which is inherently more time consuming.", "The well sidewall light blocking material is then formed by conformally depositing the light absorbing blocking material overlying the second substrate top surface and filling the wells, and etching the light absorbing blocking material to expose the emissive elements.", "Additional details of the above-described method and an emissive display substrate with light management system are provided below." ], [ "RELATED APPLICATIONS Any and all applications, if any, for which a foreign or domestic priority claim is identified in the Application Data Sheet of the present application are hereby incorporated by reference under 37 CFR 1.57.BACKGROUND OF THE INVENTION 1.Field of the Invention This invention generally relates to emissive displays and, more particularly, to a light management system for an emissive display made using the micro-size emissive elements.", "2.Description of the Related Art A red-green-blue (RGB) display can be made with micro-sized emissive elements, such as a micro light emitting diode (μLED).", "Such a display might be used in a television, computer monitor, or handheld device.", "Micro-sized emissive elements may have a diameter or cross-section of less than 100 microns.", "The emissive elements are aligned in some manner into pixel arrays.", "Conventional processing and integration steps following the placement of emissive elements include metallization to connect the emissive elements to a matrix of control lines.", "If the display is fabricated using a fluidic fabrication process, the display substrate is formed with an array of wells to capture the emissive elements.", "Typically, the display substrate is made of a transparent material such as glass.", "As a result, light can leak propagate through the transparent substrate between adjacent wells, which degrades color quality and contrast.", "It would be advantageous if the light emission from each emissive substrate well could be controlled such that light from the emissive elements in wells is only directed to the top surface of a transparent surface, and prevented from propagating into adjacent wells.", "SUMMARY OF THE INVENTION Described herein are structural features used with direct emitting emissive elements, such as micro light emitting diodes (uLEDs), which control the directionality of light emitted.", "An emissive display may be composed of a multitude of uLED pixels; each one addressed individually.", "It is important that the direction of the light emitted by each uLED is controlled to reduce light leakage between pixels to ensure color quality and contrast.", "The light from each uLED is emitted from all surfaces including the faces and the sides and is thus emitted in directions perpendicular and parallel to the surface of the display.", "Unless controlled, the light emitted along the direction nominally parallel to a transparent display substrate surface will propagate to adjacent pixels.", "The structure features described herein are used to reflect or absorb this light.", "Reflective materials may include metals already incorporated into the backplane manufacturing, including aluminum, titanium, silver, tin, indium, nickel, gold, or other reflective metals.", "Absorptive materials may include black polymer resin and black photoresist materials containing carbon black or graphene oxide.", "Accordingly, a method is provided for fabricating an emissive display substrate with a light management system.", "The method provides a transparent first substrate with a top surface and forms a plurality of emissive element wells.", "The well sidewalls are formed from a light blocking material.", "In the simplest case, the wells are formed in the first substrate.", "As mentioned above, the light blocking material may be a light absorbing material or a light reflector material.", "In one aspect, a light blocking material film layer is formed overlying the first substrate top surface, and the emissive element sidewalls are formed in the light blocking material film layer.", "In another aspect, a transparent second substrate is formed overlying the first substrate top surface.", "Then, the emissive element wells are formed in the second substrate with via surfaces, and the light blocking material is deposited overlying the well via surfaces.", "Additionally, the light blocking material may be formed on the bottom surface of each well.", "If the first substrate includes electrical interfaces formed on the top surface, the emissive element wells formed in the second substrate are etched to expose an electrical interface formed on each well bottom surface.", "Then, the light blocking material on the well bottom surface is patterned to avoid the electrical interface formed on the well bottom surface.", "In another aspect, prior to depositing the light blocking material, a fluidic assembly process is used to populate the wells with emissive elements.", "Note, the wells can also be populated using a pick-and-place process, which is inherently more time consuming.", "The well sidewall light blocking material is then formed by conformally depositing the light absorbing blocking material overlying the second substrate top surface and filling the wells, and etching the light absorbing blocking material to expose the emissive elements.", "Additional details of the above-described method and an emissive display substrate with light management system are provided below.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a partial cross-sectional view of an emissive display substrate with a light management system.", "FIG.", "2 is a partial cross-sectional view depicting a first variation of the light management system.", "FIG.", "3 is a partial cross-sectional view depicting a second variation of the light management system.", "FIGS.", "4A and 4B are, respectively, partial cross-sectional and plan views related to the second variation of light management system present in FIG.", "3.FIGS.", "5A and 5B are partial cross-sectional views depicting the display light management system subsequent to the addition of emissive elements.", "FIG.", "6 is a partial cross-sectional diagram of the light management feature enabled as a well structure created from a reflective material.", "FIG.", "7 is a partial cross-sectional view depicting a light management feature enabled as a well structure created from a light absorbing material.", "FIG.", "8 is a partial cross-sectional view depicting the light management feature enabled as a well structure coated with a light reflecting material.", "FIG.", "9 is a partial cross-sectional view of the light management feature enabled a well structure coated with a light absorbing material.", "FIG.", "10 is a partial cross-sectional view depicting the light management feature enabled as a well structure, with emissive elements overcoated with a light absorbing layer.", "FIG.", "11 is a flowchart illustrating a method for fabricating an emissive display substrate with a light management system.", "FIG.", "12 is a flowchart illustrating a method for managing the direction of light emitted from an emissive display substrate.", "DETAILED DESCRIPTION FIG.", "1 is a partial cross-sectional view of an emissive display substrate with a light management system.", "The display 100 comprises a first substrate 102 with a first substrate top surface 104.For example, the first substrate 102 may be a transparent material such as glass or plastic, but alternatively the material be a non-transparent plastic, metal, or silicon material.", "A plurality of emissive element wells 106 exists (one well is shown), with well sidewalls formed from a light blocking material 108.In one simple aspect as shown, the wells 106 are formed directly in the first substrate 102.The light blocking material may be either a light absorbing material or a light reflector material.", "Some examples of a light absorber material include a black polymer resin, a black photoresist, a material comprising carbon black, or a material comprising graphene oxide.", "Some examples of a light reflector material include aluminum, titanium, silver, tin, indium, nickel, and gold.", "Advantageously, these materials are commonly used in thin-film display and integrated circuit (IC) fabrication processes.", "In one aspect, for example see FIG.", "8, the well via surfaces and sidewalls are sloped.", "FIG.", "2 is a partial cross-sectional view depicting a first variation of the light management system.", "In this aspect, the light blocking material forms a film layer 108 overlying the first substrate top surface 104.The wells 106 are formed in the light blocking material film layer 108.Although not shown, the light blocking film layer need not necessary be etched to expose the first substrate top surface when the well is formed.", "FIG.", "3 is a partial cross-sectional view depicting a second variation of the light management system.", "In this aspect, a transparent second substrate 300 with a top surface 302 overlies the first substrate top surface 104.The wells 106 are formed in the second substrate 300 with well via surfaces 302, and light blocking material sidewalls 108 overlie the well via surfaces.", "Although not shown, the second substrate need not necessary be etched to expose the first substrate top surface when the well is formed.", "FIGS.", "4A and 4B are, respectively, partial cross-sectional and plan views related to the second variation of light management system present in FIG.", "3.In this aspect, the light blocking material 402 is formed on a bottom surface 400 of each well 106.Note, light blocking material 402 and 108 are typically the same material formed in the same process, but have been given different reference designators for the purpose of clarity.", "Although not shown, the second substrate need not necessary be etched to expose the first substrate top surface when the well is formed.", "If an electrical interface 404 is formed on each well bottom surface 400, as shown in FIG.", "4B, the light blocking material 402 on the bottom surface 400 of each well is patterned to avoid the electrical interface formed on the well bottom surface.", "In this example the well is shown as having a circular shape, but other shapes (e.g., square, rectangular, oval, etc.)", "are also possible.", "Although not shown, each well may include an additional electrical interface that would be exposed by the patterning of the light blocking material 402.FIGS.", "5A and 5B are partial cross-sectional views depicting the display light management system subsequent to the addition of emissive elements.", "In this aspect, the display 100 further comprises emissive elements 500 populating the wells 106.Optionally, as shown in FIG.", "5A, if the wells 106 include an electrical interface 404 formed on each well bottom surface 400, the emissive elements 500 each have an electrical contact 502 connected to the electrical interface formed on the well bottom surfaces.", "In some aspects not shown, the well bottom surface includes two electrical interfaces and the emissive element includes two electrical contacts.", "Although a second transparent substrate 300 is used in this example, with light blocking sidewalls 108, alternatively, the light blocking sidewalls can be formed from a light blocking film layer, as shown in FIG.", "2.As shown in FIG.", "5B, wells 106 are formed in the top surface 504 of second substrate 300.Absorbing type light blocking material 506 overlies the second substrate top surface 504 and forms the well sidewalls.", "Absorbing type light blocking material 506 is patterned to expose a top surface 508 of each emissive element 500.The variations presented above describe structural elements employed within a direct emitting emissive element display to control the directionality of the light emitted by the emissive element.", "One example of an emissive element is a micro light emitting diode (uLED).", "The display is comprised of a multitude of uLED pixels; each one addressed individually.", "It is important that the direction of the light emitted by each uLED is controlled to reduce light leakage between pixels to ensure color quality and contrast.", "The light from each uLED is emitted from all surfaces including the faces and the sides and is thus emitted in directions perpendicular and parallel to the surface of the display substrate.", "The light emitted along the direction nominally parallel to the surface would propagate to adjacent pixels without a structure to reflect or absorb this light.", "These structural elements are either an absorbing or reflecting type.", "Reflective materials that can be used include metals already incorporated into the backplane manufacturing including aluminum, titanium, silver, tin, indium, nickel, gold or other reflective metals.", "Absorptive materials include black polymer resin and black photoresist materials containing carbon black or graphene oxide.", "FIG.", "6 is a partial cross-sectional diagram of the light management feature enabled as a well structure created from a reflective material.", "Shown are wells 106-0 and 106-n.", "This reflective material could be metal for example.", "A substrate 102 such as glass is supplied onto which a metal electrode may be patterned (not shown) by standard photolithographic methods.", "A reflective well layer 600 is deposited several microns in thickness with exact thickness determined by the thickness of the emissive elements (500-0 and 500-n).", "The reflective well layer 600 is patterned by photolithographic methods forming wells 106-0 and 106-n. Emissive elements 500-0 and 500-n may be fluidically assembled into the well structure, and if electrical interfaces exist on the well bottom layer (not shown), they are connected to the emissive elements through a solder process.", "FIG.", "7 is a partial cross-sectional view depicting a light management feature enabled as a well structure created from a light absorbing material.", "This absorbing material could be black matrix material for example.", "A substrate 102 such as glass is supplied onto which a metal electrode (not shown) may be patterned by standard photolithographic methods.", "An absorbing well layer 700 is deposited several microns in thickness with the exact thickness determined by the thickness of the emissive element.", "The absorbing well layer 700 is patterned by photolithographic methods to form wells 106-0 and 106-n. Emissive elements 500-0 and 500-n are fluidically assembled into the well structures 106-0 and 106-n, respectively, and if electrical interfaces exist on the well bottom layer (not shown), they are connected to the emissive elements through a solder process.", "FIG.", "8 is a partial cross-sectional view depicting the light management feature enabled as a well structure coated with a light reflecting material.", "This reflecting material could be a metal for example.", "A substrate such as glass 102 is supplied onto which a metal electrode (not shown) may be patterned by standard photolithographic methods.", "Well pattern layer 300, typically made from a transparent material, is deposited to be several microns in thickness with the exact thickness determined by the thickness of the emissive element.", "The well pattern layer 300 is patterned by photolithographic methods to form wells 106-0 and 106-n. A reflective coating 800-0 and 800-n is respectively deposited on well structures 106-0 and 106-n through an evaporation or sputter process for example.", "The reflective coatings 800-0 and 800-n are patterned by photolithographic methods.", "Emissive elements 500-0 and 500-n are fluidlically assembled into the well structures 106-0 and 106-n, and if electrical interfaces exist on the well bottom layer (not shown), they are connected to the emissive elements through a solder process.", "FIG.", "9 is a partial cross-sectional view of the light management feature enabled a well structure coated with a light absorbing material.", "This absorbing material may be a black matrix material for example.", "A substrate 102 such as glass is supplied onto which a metal electrode (not shown) is optionally patterned by standard photolithographic methods.", "A transparent well pattern layer 300 is deposited several microns in thickness with the exact thickness determined by the thickness of the emissive element.", "The well layer 300 is patterned by photolithographic methods to form wells 106-0 and 106-n. An absorbing coating 900-0 and 900-n is deposited, respectively on well structures 106-0 and 106-n.", "The absorbing coating is patterned by photolithographic methods.", "Emissive elements 500-0 and 500-n are fluidically assembled, respectively, into the well structures 106-0 and 106-n, and if electrical interfaces exist on the well bottom layer (not shown), they are connected to the emissive elements through a solder process.", "FIG.", "10 is a partial cross-sectional view depicting the light management feature enabled as a well structure, with emissive elements overcoated with a light absorbing layer.", "This absorbing material 1000 can be a black matrix material for example.", "A substrate 102 such as glass is supplied onto which a metal electrode (not shown) is optionally patterned by standard photolithographic methods.", "A transparent well pattern layer 300 is deposited several microns in thickness with the exact thickness determined by the thickness of the emissive element.", "The well layer 300 is patterned by photolithographic methods to form wells 106-0 and 106-n. Emissive elements 500-0 and 500-n are fluidically assembled, respectively into the well structures 106-0 and 106-n, and if electrical interfaces exist on the well bottom layer (not shown), they are connected to the emissive elements through a solder process.", "The absorbing coating 1000 is deposited on a well structure.", "The absorbing coating 1000 is patterned by photolithographic methods.", "FIG.", "11 is a flowchart illustrating a method for fabricating an emissive display substrate with a light management system.", "Although the method is depicted as a sequence of numbered steps for clarity, the numbering does not necessarily dictate the order of the steps.", "It should be understood that some of these steps may be skipped, performed in parallel, or performed without the requirement of maintaining a strict order of sequence.", "Generally however, the method follows the numeric order of the depicted steps.", "The method starts at Step 1100.Step 1102 provides a transparent first substrate with a top surface.", "Step 1104 forms a plurality of emissive element wells, and Step 1106 forms well sidewalls from a light blocking material.", "As noted above, the blocking material may be a light absorbing material such as a black polymer resin, a black photoresist, a material comprising carbon black, or a material comprising graphene oxide.", "Otherwise, the light blocking material is a light reflector material such as aluminum, titanium, silver, tin, indium, nickel, and gold.", "In one aspect, the wells are formed directly in the first substrate.", "In another aspect, forming the emissive element wells in Step 1104 includes forming wells with sloped via surfaces, and forming well sidewalls in Step 1106 includes forming sloped well sidewalls.", "In one aspect, Step 1103a forms a light blocking material film layer overlying the first substrate top surface.", "Then, forming well sidewalls in Step 1106 includes forming the emissive element sidewalls in the light blocking material film layer.", "In this aspect, Step 1108 may use a fluidic assembly process to populate the emissive element wells with emissive elements.", "Alternatively, a pick-and-place process can be used to populate the wells.", "In another aspect, Step 1103b forms a transparent second substrate overlying the first substrate top surface.", "Then, forming the emissive element wells in Step 1104 includes forming the emissive element wells in the second substrate with via surfaces, and forming the well sidewalls in Step 1106 includes depositing the light blocking material overlying the well via surfaces.", "Optionally, Step 1106 may form the light blocking material on a bottom surface of each well.", "If Step 1102 provides the first substrate with electrical interfaces formed on the first substrate top surface, then forming the emissive element wells in Step 1104 includes etching the second substrate to expose an electrical interface formed on each well bottom surface.", "Similarly, forming the light blocking material on the bottom surface of each well in Step 1106 would then include patterning the light blocking material to avoid the electrical interface formed on the well bottom surface.", "In this aspect, Step 1108 uses a fluidic assembly process to populate the emissive element wells with emissive elements.", "Alternatively, a pick-and-place process can be used to populate the wells.", "In another aspect using the transparent second substrate, Step 1105 uses a fluidic assembly process to populate the wells with emissive elements prior to depositing the light blocking material.", "Then, forming well sidewalls from a light blocking material includes substeps.", "Step 1106a conformally deposits a light absorbing blocking material overlying the second substrate top surface and filling the wells, and Step 1106b etches the light absorbing blocking material to expose the emissive elements.", "FIG.", "12 is a flowchart illustrating a method for managing the direction of light emitted from an emissive display substrate.", "The method begins at Step 1200.Step 1202 provides a transparent substrate and a plurality of emissive element wells.", "Step 1204 forms light blocking material well sidewalls and Step 1206 populates the wells with emissive elements using a fluidic (or pick-and-place) assembly process.", "As noted in the explanation of FIG.", "11, in some aspects Step 1206 may be performed before Step 1204.In response to the light blocking material sidewalls, Step 1208 prevents the propagation of light between adjacent wells.", "An emissive display light management system has been provided.", "Examples of particular material, circuit layouts, and process steps have been presented to illustrate the invention.", "However, the invention is not limited to merely these examples.", "Other variations and embodiments of the invention will occur to those skilled in the art." ] ]
Patent_15872749
[ [ "SALMONELLA-BASED VECTORS FOR CANCER IMMUNOTHERAPY TARGETING WILMS' TUMOR GENE WT1", "The present invention relates to an attenuated mutant strain of Salmonella comprising a recombinant DNA molecule encoding Wilms' tumor Protein I.", "In particular, the present invention relates to the use of said attenuated mutant strain of Salmonella in cancer immunotherapy." ], [ "1.A method of treating cancer comprising administering to a subject an attenuated mutant strain of Salmonella comprising at least one copy of a recombinant DNA molecule comprising an expression cassette encoding Wilms' Tumor Protein (WT1) in cancer immunotherapy.", "2.The method of claim 1, wherein the attenuated mutant strain of Salmonella is Salmonella enterica typhi Ty21a.", "3.The method claim 1, wherein the expression cassette is a eukaryotic expression cassette.", "4.The method of claim 1, wherein WT1 is selected from the group consisting of human WT1 and a protein that shares at least 80% sequence identity therewith.", "5.The method of claim 1, wherein the recombinant DNA molecule comprises a kanamycin antibiotic resistance gene, a pMB1 ori, and a eukaryotic expression cassette encoding human WT1 or a protein that shares at least 80% sequence identity therewith, under the control of a CMV promoter.", "6.", "(canceled) 7.", "(canceled) 8.", "(canceled) 9.The method of claim 1, wherein the cancer immunotherapy further comprises administration of one or more further attenuated mutant strain(s) of Salmonella comprising at least one copy of a recombinant DNA molecule comprising an expression cassette encoding a tumor antigen and/or a tumor stroma antigen.", "10.The method of claim 9, wherein the attenuated mutant strain of Salmonella is co-administered with said one or more further attenuated mutant strain(s) of Salmonella.", "11.The method of claim 1, wherein cancer immunotherapy is accompanied by chemotherapy, radiotherapy or biological cancer therapy.", "12.The method of claim 1, wherein the attenuated mutant strain of Salmonella is administered orally.", "13.The method of claim 1, wherein the cancer is selected from leukemia and solid tumors.", "14.The method of claim 1, wherein the attenuated mutant strain of Salmonella is administered as a the single dose comprising from about 105 to about 1011 colony forming units (CFU).", "15.The method of claim 1, for individualized cancer immunotherapy comprising a step of assessing the tumor antigen expression pattern and/or stroma antigen expression pattern of the subject.", "16.The method of claim 1, wherein WT1 is truncated.", "17.The method of claim 16, wherein the truncated WT1 has the amino acid sequence as found in SEQ ID NO 1.18.The method of claim 9, wherein said one or more further attenuated mutant strain(s) of Salmonella is/are Salmonella typhi Ty21a comprising a eukaryotic expression cassette.", "19.The method of claim 18, wherein said one or more further attenuated mutant strain(s) of Salmonella comprise(s) an attenuated mutant strain of Salmonella encoding human VEGFR-2.20.The method of claim 13, wherein the leukemia is selected from acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL).", "21.The method of claim 13, wherein the solid tumor is selected from lung cancer, breast cancer, esophageal, colon, colorectal, gastric, cholangioductal, pancreatic cancer, glioblastoma, head and neck cancer, synovial sarcoma, angiosarcoma, osteosarcoma, thyroid cancer, cervical, endometrial, ovarian cancer, neuroblastoma, rhabdomyosarcoma and prostate cancer." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Wilms' tumor gene 1 (WT1) encodes a zinc finger transcription factor involved in cell proliferation and differentiation.", "It is highly expressed in a wide variety of malignancies including several types of hematological malignancies and various solid tumors.", "In contrast, normal tissue expression of WT1 in adults is restricted to gonads, uterus, kidney, mesothelium and CD34 + progenitor cells in various types of tissues.", "WT1 was originally proposed as a tumor suppressor gene.", "However, more recent evidence points to oncogenic functions of this transcription factor; Wt-1 negatively affects differentiation and promotes proliferation of progenitor cells.", "Furthermore, overexpressed WT1 is immunogenic; WT1 specific T cells as well as IgG anti-WT1 antibodies have been observed in cancer patients.", "Thus, WT-1 is a promising candidate for the development of cancer vaccines.", "Human clinical trials with WT1 vaccines based on HLA (human leukocyte antigen)-restricted WT1 peptide fragments have been reported.", "Osada et al., Clin Cancer Res 2009; 15:2789-2796, discloses a WT1-encoding Adenovirus Vaccine.", "To the inventor's knowledge, no live bacterial cancer vaccine targeting WT1 has been reported.", "Furthermore, no oral cancer vaccine targeting WT1 has been described.", "Attenuated derivatives of Salmonella enterica are attractive vehicles for the delivery of heterologous antigens to the mammalian immune system, since S. enterica strains can potentially be delivered via mucosal routes of immunization, i.e.", "orally or nasally, which offers advantages of simplicity and safety compared to parenteral administration.", "Furthermore, Salmonella strains elicit strong humoral and cellular immune responses at the level of both systemic and mucosal compartments.", "Batch preparation costs are relatively low and formulations of live bacterial vaccines are highly stable.", "Attenuation can be accomplished by deletion of various genes, including virulence, regulatory, and metabolic genes.", "Several Salmonella typhimurium strains attenuated by aro mutations have been shown to be safe and effective delivery vehicles for heterologous antigens in animal models.", "Approaches of delivering DNA constructs encoding antigens, in particular VEGF receptor proteins, via live attenuated Salmonella typhimurium strains into mouse target cells are described in WO 03/073995.Niethammer et al., (Nature Medicine 2002, 8(12), 1369) demonstrated that the attenuated S. typhimurium aroA strain SL7207 harboring an expression vector encoding the murine vascular endothelial growth factor receptor 2 (VEGFR-2 or FLK-1), which is essential for tumor angiogenesis, is functional as a cancer vaccine.", "There is however only one attenuated Salmonella enterica serovar strain, namely Salmonella enterica serovar typhi Ty21a (short: S. typhi Ty21a), which has been accepted for use in humans and is distributed under the trade name of Vivotif® (Berna Biotech Ltd., a Crucell Company, Switzerland; marketing authorization number PL 15747/0001 dated 16 Dec. 1996).", "This well-tolerated, live oral vaccine against typhoid fever was derived by chemical mutagenesis of the wild-type virulent bacterial isolate S. typhi Ty2 and harbors a loss-of-function mutation in the galE gene, as well as other less defined mutations.", "It has been licensed as typhoid vaccine in many countries after it was shown to be efficacious and safe in field trials.", "WT1 is a promising tumor antigen for the development of cancer vaccines.", "Major limitations of previously available WT1 peptide vaccines are HLA-restriction and parenteral administration.", "The great need for improved cancer therapy approaches based on targeting WT1 has not been met so far." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>In one aspect, the present invention relates to an attenuated mutant strain of Salmonella comprising at least one copy of a recombinant DNA molecule comprising an expression cassette encoding Wilms' Tumor Protein (WT1).", "The attenuated Salmonella strain of the present invention was shown to exhibit antitumor activity in a mouse model challenged with murine leukemia cells.", "To the inventor's knowledge, this novel attenuated Salmonella strain is the first live bacterial cancer vaccine targeting WT1.In addition, the attenuated.", "Salmonella strain of the present invention is the first oral cancer vaccine targeting WT1.Since WT1 is overexpressed in a wide variety of hematological malignancies and solid tumor, the attenuated Salmonella strain of the present invention has great potential as universal cancer vaccine.", "In a first study, the vaccine according to the present invention (VXM06) has been demonstrated to efficiently prolong survival of mice bearing intraperitoneally implanted leukemia cells.", "These results indicate that vaccination with VXM06 may lead to an immune response and the development of an immune memory against tumor cells overexpressing WT1.It is remarkable and surprising that the novel vaccine VXM06 is effective at relatively low doses.", "The attenuated Salmonella mutant strain of the present invention may be applied in monotherapy or in combination with a second attenuated mutant strain of Salmonella comprising a DNA molecule encoding a second tumor antigen.", "Furthermore, the attenuated mutant strain of the present invention may be administered in combination with chemotherapy, radiotherapy or biological cancer therapy.", "Treatment with VXM06 may also be effective, if the patient has developed a resistance to chemotherapy (chemo-refractory patients).", "The novel attenuated Salmonella strain of the present invention might therefore be useful in novel, greatly improved cancer therapy approaches.", "In particular embodiments, the attenuated mutant strain of Salmonella is of the species Salmonella enterica .", "In particular embodiments, the attenuated mutant strain of Salmonella is Salmonella typhi Ty21a.", "In particular embodiments, the expression cassette is a eukaryotic expression cassette.", "In particular embodiments, WT1 is selected from the group consisting of human WT1 and a protein that shares at least about 80% sequence identity therewith.", "In particular embodiments, WT1 is truncated.", "In particular embodiments, the zinc finger domain of WT1 is deleted.", "In particular embodiments, the truncated WT1 has the amino acid sequence as found in SEQ ID NO 1.In particular embodiments, the recombinant DNA molecule comprises the kanamycin antibiotic resistance gene, the pMB1 ori, and a eukaryotic expression cassette encoding human WT1 or a protein that shares at least 80% sequence identity therewith, particularly truncated human WT1, under the control of a CMV promoter.", "In particular embodiments, the recombinant DNA molecule is a plasmid designated pVAX10.hWT1 and has the nucleic acid sequence as found in SEQ ID NO 2.In particular embodiments, the attenuated mutant strain of Salmonella is for use as a medicament.", "In particular embodiments, the attenuated mutant strain of Salmonella is for use as a vaccine.", "In particular embodiments, the attenuated mutant strain of Salmonella is for use in cancer immunotherapy.", "In particular embodiments, cancer immunotherapy further comprises administration of one or more further attenuated mutant strain(s) of Salmonella comprising at least one copy of a recombinant DNA molecule comprising an expression cassette encoding a tumor antigen and/or a tumor stroma antigen.", "In particular embodiments, said one or more further attenuated mutant strain(s) of Salmonella is/are Salmonella typhi Ty21a comprising a eukaryotic expression cassette.", "In particular embodiments, said one or more further strain(s) of Salmonella comprise(s) an attenuated mutant strain(s) of Salmonella encoding human VEGFR-2.In particular embodiments, the attenuated mutant strain of Salmonella is co-administered with said one or more further attenuated mutant strain(s) of Salmonella.", "In particular embodiments, cancer immunotherapy is accompanied by chemotherapy, radiotherapy or biological cancer therapy.", "In particular embodiments, the attenuated mutant strain of Salmonella is administered during the chemotherapy or the radiotherapy treatment cycle or during biological cancer therapy.", "In particular embodiments, the attenuated mutant strain of Salmonella is administered before the chemotherapy or the radiotherapy treatment cycle or before biological cancer therapy.", "In particular embodiments, the attenuated mutant strain of Salmonella is administered after the chemotherapy or the radiotherapy treatment cycle or after biological cancer therapy.", "In further embodiments the attenuated mutant strain of Salmonella is administered before and during at least one of the chemotherapy, the radiotherapy treatment cycle and the biological cancer therapy.", "In cases where more than one of the chemotherapy, the radiotherapy and the biological cancer therapy are carried out the attenuated mutant strain of Salmonella may be administered before or during or before and during at least one of these therapies, particularly during at least two of these therapies.", "In particular embodiments, the attenuated mutant strain of Salmonella is administered orally.", "In particular embodiments, the cancer is selected from leukemia, particularly from acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), and from solid tumors, particularly from lung cancer, breast cancer, esophageal, colon, colorectal, gastric, cholangioductal, pancreatic cancer, glioblastoma, head and neck cancer, synovial sarcoma, angiosarcoma, osteosarcoma, thyroid cancer, cervical, endometrial, ovarian cancer, neuroblastoma, rhabdomyosarcoma, prostate cancer.", "In particular embodiments, the single dose is from about 10 5 to about 10 11 , particularly from about 10 6 to about 10 10 , more particularly from about 10 6 to about 10 9 , more particularly from about 10 6 to about 10 8 , most particularly from about 10 6 to about 10 7 colony forming units (CFU).", "In particular embodiments, the attenuated mutant strain of Salmonella is for use in personalized cancer immunotherapy comprising the step of assessing the tumor antigen expression pattern and/or stroma antigen expression pattern of a patient." ], [ "FIELD OF THE INVENTION The present invention relates to an attenuated mutant strain of Salmonella comprising a recombinant DNA molecule encoding Wilms' tumor Protein 1.In particular, the present invention relates to the use of said attenuated mutant strain of Salmonella in cancer immunotherapy.", "BACKGROUND OF THE INVENTION Wilms' tumor gene 1 (WT1) encodes a zinc finger transcription factor involved in cell proliferation and differentiation.", "It is highly expressed in a wide variety of malignancies including several types of hematological malignancies and various solid tumors.", "In contrast, normal tissue expression of WT1 in adults is restricted to gonads, uterus, kidney, mesothelium and CD34+ progenitor cells in various types of tissues.", "WT1 was originally proposed as a tumor suppressor gene.", "However, more recent evidence points to oncogenic functions of this transcription factor; Wt-1 negatively affects differentiation and promotes proliferation of progenitor cells.", "Furthermore, overexpressed WT1 is immunogenic; WT1 specific T cells as well as IgG anti-WT1 antibodies have been observed in cancer patients.", "Thus, WT-1 is a promising candidate for the development of cancer vaccines.", "Human clinical trials with WT1 vaccines based on HLA (human leukocyte antigen)-restricted WT1 peptide fragments have been reported.", "Osada et al., Clin Cancer Res 2009; 15:2789-2796, discloses a WT1-encoding Adenovirus Vaccine.", "To the inventor's knowledge, no live bacterial cancer vaccine targeting WT1 has been reported.", "Furthermore, no oral cancer vaccine targeting WT1 has been described.", "Attenuated derivatives of Salmonella enterica are attractive vehicles for the delivery of heterologous antigens to the mammalian immune system, since S. enterica strains can potentially be delivered via mucosal routes of immunization, i.e.", "orally or nasally, which offers advantages of simplicity and safety compared to parenteral administration.", "Furthermore, Salmonella strains elicit strong humoral and cellular immune responses at the level of both systemic and mucosal compartments.", "Batch preparation costs are relatively low and formulations of live bacterial vaccines are highly stable.", "Attenuation can be accomplished by deletion of various genes, including virulence, regulatory, and metabolic genes.", "Several Salmonella typhimurium strains attenuated by aro mutations have been shown to be safe and effective delivery vehicles for heterologous antigens in animal models.", "Approaches of delivering DNA constructs encoding antigens, in particular VEGF receptor proteins, via live attenuated Salmonella typhimurium strains into mouse target cells are described in WO 03/073995.Niethammer et al., (Nature Medicine 2002, 8(12), 1369) demonstrated that the attenuated S. typhimurium aroA strain SL7207 harboring an expression vector encoding the murine vascular endothelial growth factor receptor 2 (VEGFR-2 or FLK-1), which is essential for tumor angiogenesis, is functional as a cancer vaccine.", "There is however only one attenuated Salmonella enterica serovar strain, namely Salmonella enterica serovar typhi Ty21a (short: S. typhi Ty21a), which has been accepted for use in humans and is distributed under the trade name of Vivotif® (Berna Biotech Ltd., a Crucell Company, Switzerland; marketing authorization number PL 15747/0001 dated 16 Dec. 1996).", "This well-tolerated, live oral vaccine against typhoid fever was derived by chemical mutagenesis of the wild-type virulent bacterial isolate S. typhi Ty2 and harbors a loss-of-function mutation in the galE gene, as well as other less defined mutations.", "It has been licensed as typhoid vaccine in many countries after it was shown to be efficacious and safe in field trials.", "WT1 is a promising tumor antigen for the development of cancer vaccines.", "Major limitations of previously available WT1 peptide vaccines are HLA-restriction and parenteral administration.", "The great need for improved cancer therapy approaches based on targeting WT1 has not been met so far.", "OBJECTS OF THE INVENTION In view of the prior art, it is an object of the present invention to provide a novel oral WT1 targeting cancer vaccine.", "Such a WT1 targeting cancer vaccine would offer major advantages for improving the treatment options for cancer patients.", "SUMMARY OF THE INVENTION In one aspect, the present invention relates to an attenuated mutant strain of Salmonella comprising at least one copy of a recombinant DNA molecule comprising an expression cassette encoding Wilms' Tumor Protein (WT1).", "The attenuated Salmonella strain of the present invention was shown to exhibit antitumor activity in a mouse model challenged with murine leukemia cells.", "To the inventor's knowledge, this novel attenuated Salmonella strain is the first live bacterial cancer vaccine targeting WT1.In addition, the attenuated.", "Salmonella strain of the present invention is the first oral cancer vaccine targeting WT1.Since WT1 is overexpressed in a wide variety of hematological malignancies and solid tumor, the attenuated Salmonella strain of the present invention has great potential as universal cancer vaccine.", "In a first study, the vaccine according to the present invention (VXM06) has been demonstrated to efficiently prolong survival of mice bearing intraperitoneally implanted leukemia cells.", "These results indicate that vaccination with VXM06 may lead to an immune response and the development of an immune memory against tumor cells overexpressing WT1.It is remarkable and surprising that the novel vaccine VXM06 is effective at relatively low doses.", "The attenuated Salmonella mutant strain of the present invention may be applied in monotherapy or in combination with a second attenuated mutant strain of Salmonella comprising a DNA molecule encoding a second tumor antigen.", "Furthermore, the attenuated mutant strain of the present invention may be administered in combination with chemotherapy, radiotherapy or biological cancer therapy.", "Treatment with VXM06 may also be effective, if the patient has developed a resistance to chemotherapy (chemo-refractory patients).", "The novel attenuated Salmonella strain of the present invention might therefore be useful in novel, greatly improved cancer therapy approaches.", "In particular embodiments, the attenuated mutant strain of Salmonella is of the species Salmonella enterica.", "In particular embodiments, the attenuated mutant strain of Salmonella is Salmonella typhi Ty21a.", "In particular embodiments, the expression cassette is a eukaryotic expression cassette.", "In particular embodiments, WT1 is selected from the group consisting of human WT1 and a protein that shares at least about 80% sequence identity therewith.", "In particular embodiments, WT1 is truncated.", "In particular embodiments, the zinc finger domain of WT1 is deleted.", "In particular embodiments, the truncated WT1 has the amino acid sequence as found in SEQ ID NO 1.In particular embodiments, the recombinant DNA molecule comprises the kanamycin antibiotic resistance gene, the pMB1 ori, and a eukaryotic expression cassette encoding human WT1 or a protein that shares at least 80% sequence identity therewith, particularly truncated human WT1, under the control of a CMV promoter.", "In particular embodiments, the recombinant DNA molecule is a plasmid designated pVAX10.hWT1 and has the nucleic acid sequence as found in SEQ ID NO 2.In particular embodiments, the attenuated mutant strain of Salmonella is for use as a medicament.", "In particular embodiments, the attenuated mutant strain of Salmonella is for use as a vaccine.", "In particular embodiments, the attenuated mutant strain of Salmonella is for use in cancer immunotherapy.", "In particular embodiments, cancer immunotherapy further comprises administration of one or more further attenuated mutant strain(s) of Salmonella comprising at least one copy of a recombinant DNA molecule comprising an expression cassette encoding a tumor antigen and/or a tumor stroma antigen.", "In particular embodiments, said one or more further attenuated mutant strain(s) of Salmonella is/are Salmonella typhi Ty21a comprising a eukaryotic expression cassette.", "In particular embodiments, said one or more further strain(s) of Salmonella comprise(s) an attenuated mutant strain(s) of Salmonella encoding human VEGFR-2.In particular embodiments, the attenuated mutant strain of Salmonella is co-administered with said one or more further attenuated mutant strain(s) of Salmonella.", "In particular embodiments, cancer immunotherapy is accompanied by chemotherapy, radiotherapy or biological cancer therapy.", "In particular embodiments, the attenuated mutant strain of Salmonella is administered during the chemotherapy or the radiotherapy treatment cycle or during biological cancer therapy.", "In particular embodiments, the attenuated mutant strain of Salmonella is administered before the chemotherapy or the radiotherapy treatment cycle or before biological cancer therapy.", "In particular embodiments, the attenuated mutant strain of Salmonella is administered after the chemotherapy or the radiotherapy treatment cycle or after biological cancer therapy.", "In further embodiments the attenuated mutant strain of Salmonella is administered before and during at least one of the chemotherapy, the radiotherapy treatment cycle and the biological cancer therapy.", "In cases where more than one of the chemotherapy, the radiotherapy and the biological cancer therapy are carried out the attenuated mutant strain of Salmonella may be administered before or during or before and during at least one of these therapies, particularly during at least two of these therapies.", "In particular embodiments, the attenuated mutant strain of Salmonella is administered orally.", "In particular embodiments, the cancer is selected from leukemia, particularly from acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), and from solid tumors, particularly from lung cancer, breast cancer, esophageal, colon, colorectal, gastric, cholangioductal, pancreatic cancer, glioblastoma, head and neck cancer, synovial sarcoma, angiosarcoma, osteosarcoma, thyroid cancer, cervical, endometrial, ovarian cancer, neuroblastoma, rhabdomyosarcoma, prostate cancer.", "In particular embodiments, the single dose is from about 105 to about 1011, particularly from about 106 to about 1010, more particularly from about 106 to about 109, more particularly from about 106 to about 108, most particularly from about 106 to about 107 colony forming units (CFU).", "In particular embodiments, the attenuated mutant strain of Salmonella is for use in personalized cancer immunotherapy comprising the step of assessing the tumor antigen expression pattern and/or stroma antigen expression pattern of a patient.", "DETAILED DESCRIPTION OF THE INVENTION The present invention may be understood more readily by reference to the following detailed description of the invention and the examples included therein.", "In one aspect, the present invention relates to an attenuated mutant strain of Salmonella comprising at least one copy of a recombinant DNA molecule comprising an expression cassette encoding Wilms' Tumor Protein (WT1).", "According to the invention, the attenuated Salmonella strain functions as the bacterial carrier of the recombinant DNA molecule comprising an expression cassette encoding Wilms' Tumor Protein (WT1) for the delivery of said recombinant DNA molecule into a target cell.", "In the context of the present invention, the term “attenuated” refers to a bacterial strain of reduced virulence compared to the parental bacterial strain, not harboring the attenuating mutation.", "Attenuated bacterial strains have preferably lost their virulence but retained their ability to induce protective immunity.", "Attenuation can be accomplished by deletion of various genes, including virulence, regulatory, and metabolic genes.", "Attenuated bacteria may be found naturally or they may be produced artificially in the laboratory, for example by adaptation to a new medium or cell culture or they may be produced by recombinant DNA technology.", "In the context of the present invention, the term “mutant strain” refers to a bacterial strain harboring a mutation in its genome.", "In this context, the term “mutation” refers to a change in a nucleic acid sequence, including point mutations, insertions, deletions, translocations and inversions.", "In the context of the present invention, the term “comprises” or “comprising” means “including, but not limited to”.", "The term is intended to be open-ended, to specify the presence of any stated features, elements, integers, steps or components, but not to preclude the presence or addition of one or more other features, elements, integers, steps, components or groups thereof.", "The term “comprising” thus includes the more restrictive terms “consisting of” and “essentially consisting of”.", "In one embodiment the term “comprising” as used throughout the application and in particular within the claims may be replaced by the term “consisting of”.", "In the context of the present invention, the term “recombinant DNA molecule” refers to an engineered DNA construct, preferably composed of DNA pieces of different origin.", "The recombinant DNA molecule can be a linear nucleic acid, or preferably, a circular recombinant DNA plasmid generated by introducing an open reading frame encoding WT1 into an expression vector plasmid.", "In the context of the present invention, the term “expression cassette” refers to a nucleic acid unit comprising at least the WT1 gene under the control of regulatory sequences controlling its expression.", "The expression cassette comprised in the attenuated mutant strain of Salmonella can preferably mediate transcription of the included open reading frame encoding WT1 in a target cell.", "Expression cassettes typically comprise a promoter, at least one open reading frame and a transcription termination signal.", "The zinc finger transcription factor Wilms' tumor protein 1 is encoded by the WT1 gene.", "It contains four zinc finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus.", "Multiple transcript variants, resulting from alternative splicing at two coding exons, have been well characterized.", "WT1 plays an essential role in the development of the urogenital system and is involved in cell proliferation and differentiation.", "The WT1 gene was isolated as the gene responsible for a childhood renal neoplasm, Wilms' tumor.", "It is highly expressed in a wide variety of malignancies including several types of hematological malignancies and various solid tumors.", "In contrast, normal tissue expression of WT1 in adults is restricted to gonads, uterus, kidney, mesothelium and progenitor cells in various types of tissues.", "Due to its expression profile, its oncogenic functions and its immunogenic potential, the tumor antigen WT1 is a promising candidate for the development of cancer vaccines.", "In particular embodiments, the attenuated mutant strain of Salmonella is of the species Salmonella enterica.", "In particular embodiments, the attenuated mutant strain of Salmonella is Salmonella typhi Ty21a.", "The attenuated S. typhi Ty21a strain is the active component of Typhoral L®, also known as Vivotif® (manufactured by Berna Biotech Ltd., a Crucell Company, Switzerland).", "It is currently the only licensed live oral vaccine against typhoid fever.", "This vaccine has been extensively tested and has proved to be safe regarding patient toxicity as well as transmission to third parties (Wandan et al., J.", "Infectious Diseases 1982, 145:292-295).", "The vaccine is licensed in more than 40 countries.", "The Marketing Authorization number of Typhoral L® is PL 15747/0001 dated 16 Dec. 1996.One dose of vaccine contains at least 2×109 viable S. typhi Ty21a colony forming units and at least 5×109 non-viable S. typhi Ty21a cells.", "One of the biochemical properties of the Salmonella typhi Ty21a bacterial strain is its inability to metabolize galactose.", "The attenuated bacterial strain is also not able to reduce sulfate to sulfide which differentiates it from the wild-type Salmonella typhi Ty2 strain.", "With regard to its serological characteristics, the Salmonella typhi Ty21a strain contains the O9-antigen which is a polysaccharide of the outer membrane of the bacteria and lacks the O5-antigen which is in turn a characteristic component of Salmonella typhimurium.", "This serological characteristic supports the rationale for including the respective test in a panel of identity tests for batch release.", "In particular embodiments, the expression cassette is a eukaryotic expression cassette.", "In the context of the present invention, the term “eukaryotic expression cassette” refers to an expression cassette which allows for expression of the open reading frame in a eukaryotic cell.", "It has been shown that the amount of heterologous antigen required to induce an adequate immune response may be toxic for the bacterium and result in cell death, over-attenuation or loss of expression of the heterologous antigen.", "Using a eukaryotic expression cassette that is not expressed in the bacterial vector but only in the target cell may overcome this toxicity problem and the protein expressed may exhibit a eukaryotic glycosylation pattern.", "A eukaryotic expression cassette comprises regulatory sequences that are able to control the expression of an open reading frame in a eukaryotic cell, preferably a promoter and a polyadenylation signal.", "Promoters and polyadenylation signals included in the recombinant DNA molecules comprised by the attenuated mutant strain of Salmonella of the present invention are preferably selected to be functional within the cells of the subject to be immunized.", "Examples of suitable promoters, especially for the production of a DNA vaccine for humans, include but are not limited to promoters from Cytomegalovirus (CMV), such as the strong CMV immediate early promoter, Simian Virus 40 (SV40), Mouse Mammary Tumor Virus (MMTV), Human Immunodeficiency Virus (HIV), such as the HIV Long Terminal Repeat (LTR) promoter, Moloney virus, Epstein Barr Virus (EBV), and from Rous Sarcoma Virus (RSV) as well as promoters from human genes such as human actin, human myosin, human hemoglobin, human muscle creatine, and human metallothionein.", "In a particular embodiment, the eukaryotic expression cassette contains the CMV promoter.", "In the context of the present invention, the term “CMV promoter” refers to the strong immediate-early cytomegalovirus promoter.", "Examples of suitable polyadenylation signals, especially for the production of a DNA vaccine for humans, include but are not limited to the bovine growth hormone (BGH) polyadenylation site, SV40 polyadenylation signals and LTR polyadenylation signals.", "In a particular embodiment, the eukaryotic expression cassette included in the recombinant DNA molecule comprised by the attenuated mutant strain of Salmonella of the present invention comprises the BGH polyadenylation site.", "In addition to the regulatory elements required for expression of the heterologous WT1 gene, like a promoter and a polyadenylation signal, other elements can also be included in the recombinant DNA molecule.", "Such additional elements include enhancers.", "The enhancer can be, for example, the enhancer of human actin, human myosin, human hemoglobin, human muscle creatine and viral enhancers such as those from CMV, RSV and EBV.", "Regulatory sequences and codons are generally species dependent, so in order to maximize protein production, the regulatory sequences and codons are preferably selected to be effective in the species to be immunized.", "The person skilled in the art can produce recombinant DNA molecules that are functional in a given subject species.", "In particular embodiments, WT1 is selected from the group consisting of human WT1 and a protein that shares at least about 80% sequence identity therewith.", "In this context, the term “about” or “approximately” means within 80% to 120%, alternatively within 90% to 110%, including within 95% to 105% of a given value or range.", "In the context of the present invention, the term “protein that shares at least about 80% sequence identity with human WT1” refers to a protein that differs in the amino acid sequence and/or the nucleic acid sequence encoding the amino acid sequence of human WT1.The protein may be of natural origin, e.g.", "a homolog of WT1 of a different species, or an engineered protein, e.g.", "an engineered WT1 derivative.", "It is known that the usage of codons is different between species.", "Thus, when expressing a heterologous protein in a target cell, it may be necessary, or at least helpful, to adapt the nucleic acid sequence to the codon usage of the target cell.", "Methods for designing and constructing derivatives of a given protein are well known to anyone of ordinary skill in the art.", "The protein that shares at least about 80% sequence identity with human WT1 may contain one or more mutations comprising an addition, a deletion and/or a substitution of one or more amino acids.", "According to the teaching of the present invention, said deleted, added and/or substituted amino acids may be consecutive amino acids or may be interspersed over the length of the amino acid sequence of the protein that shares at least about 80% sequence identity with human WT1.According to the teaching of the present invention, any number of amino acids may be added, deleted, and/or substitutes, as long as the sequence identity with human WT1 is at least about 80%.", "In particular embodiments, the sequence identity with human WT1 is at least about 80%, at least about 85%, at least about 90%, or most particularly at least about 95%.", "Methods and algorithms for determining sequence identity including the comparison of a parental protein and its derivative having deletions, additions and/or substitutions relative to a parental sequence, are well known to the practitioner of ordinary skill in the art.", "On the DNA level, the nucleic acid sequences encoding the protein that shares at least about 80% sequence identity with human WT1 may differ to a larger extent due to the degeneracy of the genetic code.", "In particular embodiments, WT1 is truncated.", "In particular embodiments, the zinc finger domain of WT1 is deleted.", "In particular embodiments, the truncated WT1 has the amino acid sequence as found in SEQ ID NO 1.The zinc finger domain at the C-terminus of WT1 comprises four zinc finger motifs.", "Truncated WT1 of the amino acid sequence as found in SEQ ID NO 1 represents amino acids 1 to 371 of UniProt ref P19544-7.Deletion of the zinc finger domain minimizes the risk of immunological cross reactivity with other zinc finger containing transcription factors.", "Furthermore, truncated WT1 lacking the zinc finger domain has greater immunogenic potential than full-length WT1.In addition, deletion of the zinc finger motifs, which are essential for DNA binding, abrogates the oncogenic potential of WT1, thus minimizing the risk of oncogenesis.", "In particular embodiments, the recombinant DNA molecule comprises the kanamycin antibiotic resistance gene, the pMB1 ori, and a eukaryotic expression cassette encoding human WT1 or a protein that shares at least 80% sequence identity therewith, particularly truncated human WT1, under the control of a CMV promoter.", "In particular embodiments, the recombinant DNA molecule is a plasmid designated pVAX10.hWT1 and has the nucleic acid sequence as found in SEQ ID NO 2.In particular embodiments, the recombinant DNA molecule is derived from commercially available pVAX1™ expression plasmid (Invitrogen, San Diego, Calif.).", "This expression vector was modified by replacing the high copy pUC origin of replication by the low copy pMB1 origin of replication of pBR322.The low copy modification was made in order to reduce the metabolic burden and to render the construct more stable.", "The generated expression vector backbone was designated pVAX10.Inserting human, truncated WT1 into this expression vector backbone via NheI/XhoI yielded the expression plasmid pVAX10.hWT1 having the nucleic acid sequence as found in SEQ ID NO 2.The expression plasmid pVAX10.hWT1 is schematically depicted in FIG.", "3.In particular embodiments, the attenuated mutant strain of Salmonella is for use as a medicament.", "In particular embodiments, the attenuated mutant strain of Salmonella is for use as a vaccine.", "In the context of the present invention, the term “vaccine” refers to an agent which is able to induce an immune response in a subject upon administration.", "A vaccine can preferably prevent, ameliorate or treat a disease.", "A vaccine in accordance with the present invention comprises an attenuated mutant strain of Salmonella, preferably S. typhi Ty21a.", "The vaccine in accordance with the present invention further comprises at least one copy of a recombinant DNA molecule comprising an expression cassette, preferably a eukaryotic expression cassette, encoding WT1, preferably selected from human WT1 or a protein that shares at least about 80% sequence identity therewith.", "Preferably, said WT1 is truncated, particularly the zinc finger domain is deleted.", "The live attenuated Salmonella mutant strain according to the present invention comprising a recombinant DNA molecule encoding WT1 can be used as a vehicle for the oral delivery of this recombinant DNA molecule.", "Such a delivery vector comprising a DNA molecule encoding a heterologous antigen, such as WT1, is termed DNA vaccine.", "Genetic immunization might be advantageous over conventional vaccination.", "The target DNA can be detected for a considerable period of time thus acting as a depot of the antigen.", "Sequence motifs in some plasmids, like GpC islands, are immunostimulatory and can function as adjuvants furthered by the immunostimulation due to LPS and other bacterial components.", "In contrast to peptide vaccines that can only mediate immunity against a small fragment of the WT1 protein, genetic vaccination may result in immunity against a wide variety of epitopes present over the whole length of the encoded WT1 protein.", "Apart from that, WT1 peptide vaccine, which have been used in clinical trials for the most part, have limited application due to HLA restriction of the peptides, i.e.", "their binding capacity to HLA molecules of antigen presenting cells (APCs).", "In contrast, the DNA vaccine of the present invention is not HLA restricted.", "Live bacterial vectors produce their own immunomodulatory factors such as lipopolysaccharides (LPS) in situ which may constitute an advantage over other forms of administration such as microencapsulation.", "Moreover, the use of the natural route of entry proves to be of benefit since many bacteria, like Salmonella, egress from the gut lumen via the M cells of Peyer's patches and migrate eventually into the lymph nodes and spleen, thus allowing targeting of vaccines to inductive sites of the immune system.", "The vaccine strain of Salmonella typhi, Ty21a, has been demonstrated to-date to have an excellent safety profile.", "Upon exit from the gut lumen via the M cells, the bacteria are taken up by phagocytic cells, such as macrophages and dendritic cells.", "These cells are activated by the pathogen and start to differentiate, and probably migrate into the lymph nodes and spleen.", "Due to their attenuating mutations, bacteria of the S. typhi Ty21 strain are not able to persist in these phagocytic cells but die at this time point.", "The recombinant DNA molecules are released and subsequently transferred into the cytosol of the phagocytic immune cells, either via a specific transport system or by endosomal leakage.", "Finally, the recombinant DNA molecules enter the nucleus, where they are transcribed, leading to WT1 expression in the cytosol of the phagocytic cells.", "Specific cytotoxic T cells against WT1 are induced by the activated antigen presenting cells.", "There is no data available to-date indicating that S. typhi Ty21a is able to enter the bloodstream systemically.", "The live attenuated Salmonella typhi Ty21a vaccine strain thus allows specific targeting of the immune system while exhibiting an excellent safety profile.", "Attenuated derivatives of Salmonella enterica are attractive as vehicles for the delivery of heterologous antigens to the mammalian immune system because S. enterica strains can potentially be delivered via mucosal routes of immunization, i.e.", "orally or nasally, which offers advantages of simplicity and safety compared to parenteral administration.", "Furthermore, Salmonella strains elicit strong humoral and cellular immune responses at the level of both systemic and mucosal compartments.", "In particular embodiments, the attenuated mutant strain of Salmonella is for use in cancer immunotherapy.", "In particular embodiments, cancer immunotherapy further comprises administration of one or more further attenuated mutant strain(s) of Salmonella comprising at least one copy of a recombinant DNA molecule comprising an expression cassette encoding a tumor antigen and/or a tumor stroma antigen.", "In particular embodiments, said one or more further mutant strain(s) of Salmonella is/are Salmonella typhi Ty21a comprising a eukaryotic expression cassette.", "In particular embodiments, said one or more further strain(s) of Salmonella comprise(s) an attenuated mutant strain of Salmonella encoding human VEGFR-2.Combining the attenuated mutant strain of Salmonella of the present invention with a second attenuated mutant strain comprising a DNA molecule encoding a second tumor antigen may have synergistic antitumor effects.", "In particular, simultaneous targeting of different tumor antigens may minimize the risk of tumor escape.", "Combining WT1 based cancer immunotherapy with VEGFR-2 based immunotherapy may prove especially effective, since WT1 overexpressing tumor cells and the tumor vasculature are attacked at the same time.", "In particular embodiments, the attenuated mutant strain of Salmonella is co-administered with said one or more further attenuated mutant strain(s) of Salmonella.", "In the context of the present invention, the term “co-administration” or “co-administer” means administration of two different attenuated mutant strains of Salmonella within three consecutive days, more particularly within two consecutive days, more particularly on the same day, more particularly within 12 hours.", "Most particularly, in the context of the present invention, the term “co-administration” refers to simultaneous administration of two different attenuated mutant strains of Salmonella.", "In particular embodiments, cancer immunotherapy is accompanied by chemotherapy, radiotherapy or biological cancer therapy.", "For cure of cancer, complete eradication of cancer stem cells may be essential.", "For maximal efficacy, a combination of different therapy approaches may be beneficial.", "In the context of the present invention, the term “biological cancer therapy” or “cancer immunotherapy” refers to the stimulation of the patient's immune system to attack malignant tumor cells or the tumor stroma.", "Biological cancer therapy approaches include delivery of tumor antigens, delivery of therapeutic antibodies as drugs, administration of immunostimulatory cytokines and administration of immune cells.", "Chemotherapeutic agents that may be used in combination with the attenuated mutant strain of Salmonella of the present invention may be, for example: gemcitabine, amifostine (ethyol), cabazitaxel, cisplatin, dacarbazine (DTIC), dactinomycin, docetaxel, mechlorethamine, streptozocin, cyclophosphamide, carrnustine (BCNU), lomustine (CCNU), doxorubicin (adriamycin), doxorubicin lipo (doxil), folinic acid, gemcitabine (gemzar), daunorubicin, daunorubicin lipo (daunoxome), procarbazine, ketokonazole, mitomycin, cytarabine, etoposide, methotrexate, 5-fluorouracil (5-FU), vinblastine, vincristine, bleomycin, paclitaxel (taxol), docetaxel (taxotere), aldesleukin, asparaginase, busulfan, carboplatin, cladribine, camptothecin, CPT-11, 10-hydroxy-7-ethyl-camptothecin (SN38), dacarbazine, floxuridine, fludarabine, hydroxyurea, ifosfamide, idarubicin, mesna, interferon alpha, interferon beta, irinotecan, mitoxantrone, topotecan, leuprolide, megestrol, melphalan, mercaptopurine, oxaliplatin, plicamycin, mitotane, pegaspargase, pentostatin, pipobroman, plicamycin, streptozocin, tamoxifen, teniposide, testolactone, thioguanine, thiotepa, uracil mustard, vinorelbine, chlorambucil and combinations thereof.", "Most preferred chemotherapeutic agents according to the invention in combination with VXM06 are cabazitaxel, carboplatin, oxaliplatin, cisplatin, cyclophosphamide, docetaxel, gemcitabine, doxorubicin, paclitaxel (taxol), irinotecan, vincristine, vinblastine, vinorelbin, folinic acid, 5-fluorouracil and bleomycin, especially gemcitabine.", "It may be also favorable dependent on the occurrence of possible side effects, to include treatment with antibiotics or anti-inflammatory agents.", "Should adverse events occur that resemble hypersensitivity reactions mediated by histamine, leukotrienes, or cytokines, treatment options for fever, anaphylaxis, blood pressure instability, bronchospasm, and dyspnoea are available.", "Treatment options in case of unwanted T-cell derived auto-aggression are derived from standard treatment schemes in acute and chronic graft vs. host disease applied after stem cell transplantation.", "Cyclosporin and glucocorticoids are proposed as treatment options.", "In the unlikely case of systemic Salmonella typhi Ty21a type infection, appropriate antibiotic therapy is recommended, for example with fluoroquinolones including ciprofloxacin or ofloxacin.", "Bacterial infections of the gastrointestinal tract are to be treated with respective agents, such as rifaximin.", "In particular embodiments, the attenuated mutant strain of Salmonella is administered during the chemotherapy or the radiotherapy treatment cycle or during biological cancer therapy.", "In particular embodiments, the attenuated mutant strain of Salmonella is administered before the chemotherapy or the radiotherapy treatment cycle or before biological cancer therapy.", "This approach may have the advantage that chemotherapy or radiotherapy can be performed under conditions of enhanced cancer immunity.", "In particular embodiments, the attenuated mutant strain of Salmonella is administered after the chemotherapy or the radiotherapy treatment cycle or after biological cancer therapy.", "In particular embodiments, the attenuated mutant strain of Salmonella is administered orally.", "Oral administration is simpler, safer and more comfortable than parenteral administration.", "WT1 peptide vaccines, which have been used in clinical trials for the most part, are usually administered subcutaneously or intradermally, often resulting in skin erythema and local inflammation reactions.", "These adverse effects may be overcome by oral administration of the DNA vaccine of the present invention.", "The attenuated mutant strain of Salmonella of the present invention may however also be administered by any other suitable route.", "Preferably, a therapeutically effective dose is administered to the subject, and this dose depends on the particular application, the type of malignancy, the subject's weight, age, sex and state of health, the manner of administration and the formulation, etc.", "Administration may be single or multiple, as required.", "The attenuated mutant strain of Salmonella of the present invention may be provided in the form of a solution, a suspension, lyophilisate, or any other suitable form.", "It may be provided in combination with pharmaceutically acceptable carriers, diluents, and/or excipients.", "Agents for adjusting the pH value, buffers, agents for adjusting toxicity, and the like may also be included.", "In the context of the present invention, the term “pharmaceutically acceptable” refers to molecular entities and other ingredients of pharmaceutical compositions that are physiologically tolerable and do not typically produce untoward reactions when administered to a mammal (e.g., human).", "The term “pharmaceutically acceptable” may also mean approved by a regulatory agency of a Federal or a state government or listed in the U.S. Pharmacopeia or other generally recognized pharmacopeia for use in mammals, and, more particularly, in humans.", "In particular embodiments, the cancer is selected from leukemia, particularly from acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), and from solid tumors, particularly from lung cancer, breast cancer, esophageal, colon, colorectal, gastric, cholangioductal, pancreatic cancer, glioblastoma, head and neck cancer, synovial sarcoma, angiosarcoma, osteosarcoma, thyroid cancer, cervical, endometrial, ovarian cancer, neuroblastoma, rhabdomyosarcoma, prostate cancer.", "The vaccine of the present invention is surprisingly effective at relatively low doses.", "In particular embodiments, the single dose is from about 105 to about 1011, particularly from about 106 to about 1010, more particularly from about 106 to about 109, more particularly from about 106 to about 108, most particularly from about 106 to about 107 colony forming units (CFU).", "Administration of low doses of this live bacterial vaccine minimizes the risk of excretion and thus of transmission to third parties.", "In this context, the term “about” or “approximately” means within a factor of 3, alternatively within a factor of 2, including within a factor of 1.5 of a given value or range.", "In particular embodiments, the attenuated mutant strain of Salmonella is for use in individualized cancer immunotherapy comprising the step of assessing the tumor antigen expression pattern and/or stroma antigen expression pattern of a patient.", "VXM06 can be used—either by itself or in combination with other Salmonella typhi Ty21a based cancer vaccines comprising eukaryotic expression systems—for the treatment of various cancer types.", "In particular embodiments, VXM06 may be used for individualized patient specific cancer treatment.", "For that purpose, the patient's tumor and/or stromal antigen expression pattern may be assessed in a first step for example by companion diagnostics targeting the patient's specific tumor and/or stromal antigen pattern.", "Depending on the patient's tumor and/or stromal antigen expression pattern VMX06 may be administered either alone or in combination with one or more suitable further Salmonella typhi Ty21a based cancer vaccine(s) comprising eukaryotic expression systems.", "Combinations of VXM06 with one or more further Salmonella typhi Ty21a based cancer vaccine(s) may however also be administered as fixed combinations.", "These cocktails combining two or more Salmonella typhi Ty21a based cancer vaccines can be composed from separate off the shelf products.", "The combinations, either fixed or individualized may contain VXM01 as anti-angiogenic basis therapy.", "SHORT DESCRIPTION OF FIGURES AND TABLES FIG.", "1: Amino acid sequence of truncated human WT1 encoded by WT1 cDNA contained in plasmid pVAX10.hWT1 FIG.", "2: Nucleic acid sequence of pVAX10.hWT1 FIG.", "3: Plasmid map of pVAX10.hWT1 FIG.", "4: Kaplan-Meier survival curves of mice bearing FBL-3 leukemia treated with VXM0m_empty, VXM06m and VXM06 FIG.", "5: Mean survival of mice bearing FBL-3 leukemia treated with VXM0m_empty, VXM06m and VXM06 Table 1: In vitro gene synthesis: phosphorylation reaction setup Table 2: In vitro gene synthesis: amplification of ligation product—PCR profile Table 3: Vaccine compositions Table 4: Assessment of antitumor activity—experimental design Table 5: Survival of mice bearing FBL-3 leukemia treated with VXM0m_empty, VXM06m and VXM06 Table 6: Number of dead animals after tumor challenge over time Table 7: Mean and median survival of mice bearing FBL-3 leukemia treated with VXM0m_empty, VXM06m and VXM06 EXAMPLES Example 1: Preparation of Recombinant Plasmids pVAX10.mWT1 and pVAX10.hWT1 Human truncated WT1 (1116 bp, WT1 sequence according to UniProt reference sequence P19544-7, truncated by the zinc finger domain) and murine truncated WT1 (1101 bp, WT1 sequence according to UniProt reference sequence P22561-5, truncated by the zinc finger domain) were cloned into the pVAX10 backbone derived of pVAX10.VR2-1.WT1 DNA fragments were generated by double-strand gene synthesis, where oligonucleotides were linked together using a thermostable ligase.", "Oligo Design and Synthesis: In a first step, the gene sequence of truncated human and truncated murine WT1 (truncated by the zinc finger domain) were subdivided into individual oligonucleotides of 40 to 50 bases using the software “SeqEditor” (Entelechon).", "The defined oligonucleotides overlapped and corresponded to both DNA strands.", "After synthesis of the oligonucleotides of both DNA strands, the oligonucleotides were diluted with 10 mM Tris (pH 8.5) to a final concentration of 50 pmol/μl.", "Kinase Reaction: The in vitro synthesized oligonucleotides were then phosphorylated by incubation with T4 polynucleotide kinase in order to allow for subsequent ligation of the oligonucleotides.", "Forward and reverse oligonucleotides were phosphorylated.", "The reaction setup is summarized in the following Table 1: Volume Ingredient 10 μl Primer mix 10 μl 10x T4 Polynucleotide kinase (PNK) buffer 10 μl ATP (25 mM) 68 μl Sterile water 2 μl T4 PNK (10 U/μl) The reaction mixture was incubated for 1 hour at 37° C. in a water bath.", "Then the T4 polynucleotide kinase was inactivated by a five-minute heat step at 95° C. and afterwards immediately cooled on ice until further treatment.", "12.5 μL of the kinase mixture was used directly for ligation (20 U Taq DNA ligase, 35 μl reaction volume (New England Biolabs, M0208S).", "The denaturation step at 95° C. was followed by progressive cooling (1° C./min).", "During this process, the complementary oligonucleotides assemble to a double strand DNA.", "The process was performed in a thermocycler (Personal Cycler, Biometra).", "By addition of the thermostable Taq DNA ligase, the 5′-PO4-end of the oligonucleotides were linked with the free 3′-OH-end of the following oligonucleotide.", "By repeated denaturation and renaturation steps, mismatched oligonucleotides were released.", "At the end of the program, the mixture was cooled at 4° C. Amplification of the Ligation Products by PCR: 5 μl of the obtained ligation products (about 1.1 kb) were amplified by PCR in a 50 μl volume with flanking primers as depicted in the following Table 2: no step temperature time No of cycles 1 denaturation 95° C. 5 min 1 2 denaturation 95° C. 30 sec 3 annealing 57° C. 30 sec {close oversize brace} 30x 4 elongation 72° C. 90 sec 5 extra-elongation 72° C. 5 min 1 6 cooling 4° C. ∞ 1 The PCR mixture contained the following components: 0.2-0.5 μM of each primer, 20 mM Tris-CI, pH 8.8, 10 mM KCl, 10 mM (NH4)2SO4, 2 mM MgSO4, 0.1% Triton X-100, 25 mM dNTP (each), 2 U VentR polymerase.", "The in vitro synthesized DNA fragments (human and murine truncated WT1; about 1.1 kb each) were cloned into the pVAX10 backbone via NheI/XhoI (the VEGFR-2 coding region of recombinant plasmid pVAX10.VR2-1 was replaced by truncated human or murine WT1).", "For quality control, the entire plasmids were sequenced and aligned to the respective reference sequence after transformation into E. coli.", "Both sequences proved to be free of errors.", "The resulting plasmids were designated pVAX10.mWT1 and pVAX10.hWT1.Example 2: Transformation of Attenuated Salmonella Strains with the Recombinant Plasmids S. typhi Ty 21a was transformed with plasmid pVAX10.hWT1.S.", "typhimurium SL7207 (aroK) was transformed with plasmid pVAX10.mVVT1.The transformation was performed by electroporation.", "Preparation of Competent Salmonella Cells: Glycerol cultures of S. typhi Ty21a and S. typhimurium SL7207 were inoculated on LB plates (animal component free [ACF] soy peptone).", "The plates were incubated at 37° C. overnight.", "One colony each was used for overnight-liquid-preculture.", "3 ml LB medium (ACF soy peptone) inoculated with one colony each was incubated at 37° C. and 180 rpm overnight.", "To prepare competent cells, 2×300 ml of LB medium (ACF soy peptone) were inoculated with 3 ml of the overnight culture and incubated at 37° C. and 180 rpm up to an OD600 of about 0.5.The cultures were then put on ice for 10 minutes.", "Subsequently, the bacteria were centrifuged for 10 minutes at 3000×g at 4° C. and each pellet was resuspended in 500 mL of ice cold H2Odest.", "After a new centrifugation step, the bacterial pellets were washed twice in 10% ice cold glycerol.", "Both pallets were put together in 2 ml of 10% glycerol and finally frozen in aliquots of 50 μL on dry ice.", "The used glycerol did not contain any animal ingredients (Sigma Aldrich, G5150).", "Transformation of Competent Salmonella Cells: For each transformation reaction, a 50 μl aliquot of competent cells was thawed on ice for 10 minutes.", "After adding 3-5 μL of plasmid DNA (pVAX10.hWT1 for competent S. typhi Ty21a cells and pVAX10.mWT1 for competent S. typhimurium SL7207 cells) the mixtures were incubated on ice for five minutes.", "Subsequently, the mixtures were transferred to pre-cooled cuvettes (1 mm thickness).", "The electric pulse was carried out at 12.5 kV/cm.", "Immediately afterwards, 1 ml of LB medium (ACF soy peptone) was added to the cells, the cells were transferred into a 2 ml Eppendorf tube and shaken for 1 hour at 37° C. After a short centrifugation step on a bench centrifuge (16600 rcf, 20s), the bacterial pellet was resuspended in 200 μl of LB (ACF soy peptone) antibiotic-free medium.", "The mixtures were applied with a Drigalski spatula on LB plates (ACF soy peptone) containing kanamycin (concentration=25 μg/ml or 50 μg/ml).", "The plates were incubated at 37° C. overnight.", "Plasmid Preparation of Recombinant Salmonella Clones: Three clones of each recombinant Salmonella strain were incubated overnight in 3 ml of LB medium (ACF soy peptone) containing kanamycin (50 μg/ml) at 37° C. The bacterial culture was then pelleted by centrifugation (16600 rcf, 30 s).", "Plasmid isolation was performed using the NucleoSpin Plasmid Kit from Macherey-Nagel.", "The plasmid DNA was eluted from the silica gel columns with 50 μl water.", "5 μl of the eluate was used in agarose gel electrophoresis for control.", "For long-term storage, 1 ml glycerol cultures of the positive clones were produced.", "For this purpose, 172 μl glycerol (no animal ingredients) was added to 828 μl medium of a logarithmically growing 3 ml culture in a 1 low ml screw microtube.", "The samples were stored at −70° C. until further use.", "Complete Sequencing of Recombinant Plasmid DNA Isolated from Salmonella: 3 ml of liquid LB-Kan medium (ACF soy peptone) were inoculated with one colony of recombinant Salmonella (S. typhi Ty21a harboring pVAX10.hWT1 and S. typhimurium SL7207 harboring pVAX10.mVVT1) and incubated overnight at 37° C. and 180 rpm.", "The overnight culture was pelleted by centrifugation at 1300 rpm for 30 s on a bench centrifuge (Biofuge pico, Heraeus).", "The plasmid isolation was performed with the NucleoSpin Plasmid Kit from Macherey-Nagel.", "After alkaline lysis and precipitation of high molecular weight genomic DNA and cellular components, the plasmid DNA was loaded onto columns with a silica membrane.", "After a washing step, the plasmids were eluted from the column with 50 μl of sterile water and sequenced.", "The sequences were then compared with the respective reference sequence by clone specific alignments, i.e.", "the plasmid sequences of each Salmonella clone was one by one aligned with the reference sequence.", "All sequences were in line with the respective reference sequences.", "The recombinant Salmonella strains were designated VXM06 (S. typhi Ty21a harboring plasmid pVAX10.hWT1) and VXM06m (S. typhimurium SL7207 harboring plasmid pVAX10.mVVT1).", "Example 3: Assessing Antitumor Activity of VXM06 and VXM06m in Syngeneic Leukemia Mouse Model The efficacy of VXM06 and VXM06m was assessed in a syngeneic leukemia C57/BL6J mouse model over a period of 43 days (with dose administration on alternate days for 4 occasions followed by leukemia cell inoculation at day 17).", "Two groups, each comprising 10 male mice (n=10) either received VXM06 (S. typhi Ty21a containing pVAX10.hWT1 coding for truncated human WT1) or VXM06m (S. typhimurium containing pVAX10.mWT1 coding for truncated murine WT1) at doses of 1010 CFU/occasion.", "One similarly constituted control group received VXM0m_empty (S. typhimurium vector control with no expression plasmid) at the same dose as the treated groups.", "During the study, body weight, mortality, and survival investigations were undertaken.", "Prior to this main study, a pilot study over 14 days in male C57616 mice (n=5 per group) without vaccination was performed using 5.0×106 and 3.0×107 FBL-3 cells, after which the first cell concentration was judged as optimal for the main vaccination study.", "DNA Vaccines: VXM06, VXM06m, and the S. typhimurium empty vector (VXM0m_empty) without expression plasmid were stored at ≤−80° C. until use.", "Vials being used during vaccination were not frozen again but discarded afterwards.", "The DNA vaccines under investigation are characterized in the following Table 3: Test item Batch Concentration Quantity VXM0m_empty VXM01m-e.1-01/2010 1011 CFU/ml 0.7 ml/vial (10 vials) VXM06m VXM06m-031.1-01/2012 1011 CFU/ml 0.7 ml/vial (10 vials) VXM06 VXM06-031.1-01/2012 1011 CFU/ml 0.7 ml/vial (10 vials) Route of Drug Administration: 100 μl of VXM0m_empty, VXM06m and VXM06 were applied per animal and application.", "After thawing of test items, application took place within 30 min.", "All test substances were administered by oral gavage (per os, P.O) via cannula with an injection volume of 100 μl/mouse.", "Regardless of animal groups, each animal received pre-dose application buffer to neutralize acid medium in the stomach prior to dosing (100 μl/animal/application for all dose groups).", "This buffer contained 2.6 g sodium hydrogen carbonate, 1.7 g L-ascorbic acid, 0.2 g lactose monohydrate and 100 ml of drinking water.", "Pre-dose applications were performed up to 30 minutes prior to application of the test items.", "Cell Culture: The WT1 overexpressing mouse leukemia cells FBL-3 required passaging to ensure viability and to attain the required amount of cells.", "The exponentially growing tumor cells were collected, mixed with trypan blue (at the recommended dilution 1:1) for viability determination, and manually counted using a counting chamber under optical microscope.", "FBL-3 cells were washed and resuspended in serum-free RPMI medium for injections into C57BL/6 mice.", "Vaccination and Tumor Cell Inoculation: Cell injection conditions for intraperitoneal (I.P.)", "injection: cell viability ≥97%; 5.0×106 cells/500 μl/mouse.", "Animals (30 C57BL/6 mice, 4-6 weeks, male, ≈20 g each, Charles River, France) were numbered, given a unique animal identification ear notch mark; the body weight was measured twice a week.", "Ten mice each (n=10 male) were vaccinated with VXM0m_empty, VXM06m, and VMX06.Vaccination was carried out by oral gavage of 1010 CFU/application at days 1, 3, 5, and 7.At day 17, FBL-3 tumor cells were inoculated in mice by I.P.", "route.", "The experimental design is summarized in the following Table 4: Tumor Dose Admin.", "Group Animals cells Treatment (CFU/adm) route Treatment schedule 1 10 5 × 106 VXM0m_empty 1010 (in 100 μl) PO Q2D × 4 (D1, D3, D5, D7) 2 10 5 × 106 VXM06m 1010 (in 100 μl) PO Q2D × 4 (D1, D3, D5, D7) 3 10 5 × 106 VXM96 1010 (in 100 μl) PO Q2D × 4 (D1, D3, D5, D7) Results: Survival data for the three treatment groups are listed in the following Table 5: Group 1; Group 2; Group 3; VXM0m_empty VXM06m VXM06 Day Survival Survival Survival −3 10 10 10 1 10 10 10 5 9 9 10 7 9 9 10 12 9 9 10 15 9 9 10 19 9 8 10 22 9 8 10 26 9 8 10 29 5 7 9 33 0 4 4 36 0 1 3 40 0 1 1 43 0 0 0 A daily clinical examination of all animals was performed: behavior, signs of suffering (cachexia, becoming, and difficulties moving or feeding).", "The number of dead animals after tumor challenge are listed in the following Table 6: Time Survival Dead treatment 1 9 0 VXM0m_empty 12 6 3 VXM0m_empty 15 2 4 VXM0m_empty 16 0 2 VXM0m_empty 1 8 0 VXM06m 12 7 1 VXM06m 14 6 1 VXM06m 16 4 2 VXM06m 19 1 3 VXM06m 26 0 1 VXM06m 1 10 0 VXM06 12 9 1 VXM06 14 8 1 VXM06 15 6 2 VXM06 16 4 2 VXM06 19 3 1 VXM06 v21 2 1 VXM06 22 1 1 VXM06 26 0 1 VXM06 FIG.", "4 depicts Kaplan-Meier survival curves of mice bearing FBL-3 leukemia treated with VXM0m_empty, VXM06m and VXM06.Mice treated with VXM06m and VXM06 survived longer compared to the control mice (up to 26 days).", "About 40% the mice that received VXM06m and VXM06 survived longer than those treated with VXM0m_empty.", "Mean and median survival of the three test groups are depicted in the following Table 7: VXM0m_empty VMX06m VXM06 9 8 10 Mice Survival time 1 12 12 12 2 12 14 14 3 12 16 15 4 15 16 15 5 15 19 16 6 15 19 16 7 15 19 19 8 16 26 21 9 16 22 10 26 Median 15 17.5 16 Mean 14.2 17.6 17.6 SD 1.6 4.0 4.1 SEM 0.5 1.4 1.3 Var.", "2.6 15.7 16.6 FIG.", "5 depicts the mean survival of mice bearing FBL-3 leukemia treated with VXM0m_empty, VXM06m and VXM06.Mice treated with VXM06m and VXM06 survived longer compared to the control mice.", "This study demonstrated the effectiveness of the constructs VXM06 and VXM06m in targeting WT1 overexpressing leukemia cells in a mouse model.", "The control mice treated with empty vector survived for up to 16 days after tumor cell challenge (see FIG.", "4).", "In contrast, the mice treated with VXM06m or with VXM06 showed prolonged survival compared to the mice vaccinated with the control vector VXM0m_empty (up to 26 days for both test items).", "About 40% of the mice that received VXM06m or VXM06 survived longer than those in the control group treated with VXM0m_empty.", "In summary, VXM06m and VXM06 showed a pharmacodynamic effect on the survival of test animals in this syngeneic C57616 leukemia mouse model.", "A similar pharmacodynamic effect of the two compounds VXM06m and VXM06 compared to empty vector was observed.", "These results show that these vaccines were able to trigger a response against WT1 in an immune-competent mouse leukemia model resulting in longer survival of animals compared to animals treated with empty vector." ] ]
Patent_15872750
[ [ "Implement Washing Apparatus and Method", "An implement washing apparatus is disclosed.", "A portable, rigid housing defines at least a first basin and a second basin.", "The first basin has an open top and closed side walls and bottom for containing liquid to soak the implement.", "The second basin has side walls that include a plurality of bristles in an arrangement directed generally inwardly to a center of the second basin to scrub the implement." ], [ "1.An implement washing apparatus for placement on a subdividing wall of a sink, the apparatus comprising: a first basin, a second basin, and a third basin, the first basin having an open top and a closed body for containing liquid to soak the implement, the second basin having at least one side wall having a first plurality of bristles directed generally inwardly to a center of the second basin to scrub the implement, and the third basin having at least one side wall connected with a rotating member at least partially within the third basin, the rotating member having a second plurality of bristles extending radially therefrom; and a bridge connecting the first basin with the second basin, the bridge having a downward facing arch proximate the open top of the first basin for placement on the subdividing wall of the sink, the bridge further having two bridge walls extending down from the downward facing arch, one of the two bridge walls defining a portion of the closed body of the first basin, the other of the two bridge walls defining a portion of the at least one side wall of the second basin.", "2.The implement washing apparatus in accordance with claim 1, wherein at least one of the first and second plurality of bristles are formed of a rigid, non-abrasive material.", "3.The implement washing apparatus in accordance with claim 1, wherein the housing is formed of a water-resistant, resilient material from a group of water-resistant, resilient materials that consists of: plastic, thermoplastic, acrylic, stainless steel, aluminum, carbon fiber, and rubber.", "4.An implement washing apparatus comprising: a first basin having an open top and a closed body, the first basin for containing liquid to soak the implement; a second basin connected with the first basin via the closed body, the second basin having a first plurality of bristles to scrub the implement; a bridge connecting the first basin with the second basin, the bridge having a downward facing arch proximate the open top of the first basin, the bridge further having two bridge walls extending down from the downward facing arch, one of the two bridge walls defining a portion of the closed body of the first basin, the other of the two bridge walls defining a portion of the at least one side wall of the second basin; and a third basin connected with the first or second basin, and having a rotating member that includes a second plurality of bristles extending radially from the rotating member, the second plurality of bristles being softer than the first plurality of bristles.", "5.The implement washing apparatus in accordance with claim 4, wherein at least one of the first and second plurality of the bristles are formed of a rigid, non-abrasive material.", "6.The implement washing apparatus in accordance with claim 4, wherein the first and second basins are formed of a water-resistant, resilient material from a group of water-resistant, resilient materials that consists of: plastic, thermoplastic, acrylic, stainless steel, aluminum, carbon fiber, and rubber." ], [ "<SOH> BACKGROUND <EOH>Outside of using modern dishwashers, the most common technique used for washing implements such as utensils, cutting knives, or other tools or equipment, has been to hold the implement with one hand, and alternatively scrub the implement with a brush or sponge held by the other hand and rinse under running water from a faucet.", "In some cases, implements are allowed to soak first in a basin formed by a sink, a glass, or a bowl, to soften foodstuffs or dirt that sticks to the implements.", "Yet, even in these cases, the soaked implements must be scrubbed and washed using two hands as described above.", "Further, when such basin is used, they are separate and removed from any scrubbing tool.", "The scrubbing tool may be set aside near the edge of a sink, in the sink, on the floor surrounding the sink, or in any of a number of locations removed from the basin.", "This separation leads to unnecessary difficulty and complexity in a process to wash implements, as well as requiring the user to use both hands during the washing process." ], [ "<SOH> SUMMARY <EOH>This document presents an implement washing apparatus, and a method for using the same, in which the aforementioned problems are addressed to make an implement washing process economical, easy and efficient.", "Further, the implement washing apparatus provides a unitary device, which may also be modular, for keeping the two major functions of a washing process—soaking and scrubbing—in near proximity to each other.", "In one aspect, an implement washing apparatus is made of a portable, rigid housing defining at least a first basin and a second basin, the first basin having an open top and closed side walls and bottom for containing liquid to soak the implement.", "The second basin has side walls that include a plurality of bristles in an arrangement directed generally inwardly to a center of the second basin to scrub the implement.", "In other aspect, the implement washing apparatus can have further numbers of basins, of any size, and can be adapted to fit in a sink or over a bridge between two or more compartments of a sink.", "The details of one or more embodiments are set forth in the accompanying drawings and the description below.", "Other features and advantages will be apparent from the description and drawings, and from the claims." ], [ "CROSS REFERENCE TO RELATED APPLICATION This application is a continuation of U.S. patent application Ser.", "No.", "15/351,404, entitled IMPLEMENT WASHING APPARATUS AND METHOD,” filed Nov. 14, 2016, that in turn is a continuation of U.S. patent application Ser.", "No.", "15/013,967, entitled “IMPLEMENT WASHING APPARATUS AND METHOD,” filed Feb. 2, 2016, that in turn is a continuation of U.S. patent application Ser.", "No.", "14/088,005, entitled, “IMPLEMENT WASHING APPARATUS AND METHOD,” filed Nov. 22, 2013, that in turn is a continuation of U.S. patent application Ser.", "No.", "13/012,672, entitled, “IMPLEMENT WASHING APPARATUS AND METHOD,” filed Jan. 24, 2011, that in turn claims the benefit under 35 U.S.C.", "§ 119(e) of the following provisional application, all of which is incorporated herein by reference in its entirety: U.S. Ser.", "No.", "61/297,693, entitled “IMPLEMENT WASHING APPARATUS AND METHOD,” filed Jan. 22, 2010.BACKGROUND Outside of using modern dishwashers, the most common technique used for washing implements such as utensils, cutting knives, or other tools or equipment, has been to hold the implement with one hand, and alternatively scrub the implement with a brush or sponge held by the other hand and rinse under running water from a faucet.", "In some cases, implements are allowed to soak first in a basin formed by a sink, a glass, or a bowl, to soften foodstuffs or dirt that sticks to the implements.", "Yet, even in these cases, the soaked implements must be scrubbed and washed using two hands as described above.", "Further, when such basin is used, they are separate and removed from any scrubbing tool.", "The scrubbing tool may be set aside near the edge of a sink, in the sink, on the floor surrounding the sink, or in any of a number of locations removed from the basin.", "This separation leads to unnecessary difficulty and complexity in a process to wash implements, as well as requiring the user to use both hands during the washing process.", "SUMMARY This document presents an implement washing apparatus, and a method for using the same, in which the aforementioned problems are addressed to make an implement washing process economical, easy and efficient.", "Further, the implement washing apparatus provides a unitary device, which may also be modular, for keeping the two major functions of a washing process—soaking and scrubbing—in near proximity to each other.", "In one aspect, an implement washing apparatus is made of a portable, rigid housing defining at least a first basin and a second basin, the first basin having an open top and closed side walls and bottom for containing liquid to soak the implement.", "The second basin has side walls that include a plurality of bristles in an arrangement directed generally inwardly to a center of the second basin to scrub the implement.", "In other aspect, the implement washing apparatus can have further numbers of basins, of any size, and can be adapted to fit in a sink or over a bridge between two or more compartments of a sink.", "The details of one or more embodiments are set forth in the accompanying drawings and the description below.", "Other features and advantages will be apparent from the description and drawings, and from the claims.", "BRIEF DESCRIPTION OF THE DRAWINGS These and other aspects will now be described in detail with reference to the following drawings.", "FIGS.", "1A and 1B illustrate one variation of an implement washing apparatus.", "FIGS.", "2A and 2B illustrate another variation of an implement washing apparatus.", "FIG.", "3 is a perspective view of yet another variation of an implement washing apparatus.", "FIG.", "4 is a side view of the implement washing apparatus shown in FIG.", "3.FIGS.", "5A and 5B illustrate another variation of an implement washing apparatus.", "FIG.", "6 is a perspective view of yet another variation of an implement washing apparatus.", "Like reference symbols in the various drawings indicate like elements.", "DETAILED DESCRIPTION This document describes an implement washing apparatus, and a method for making and using an implement washing apparatus.", "In preferred exemplary implementations, an implement washing apparatus includes at least a first basin for soaking one or more implements, and at least a second basin, connected with or otherwise integrated with the first basin, for scrubbing the soaked one or more implements with a set of bristles that are connected with side walls of the second basin.", "The implement washing apparatus may include a bridge for being mounted on a subdividing wall of a multi-basin sink, for example, or may include one or more suction cups or friction-bearing feet on the bottom of the apparatus to fix the implement washing apparatus in a desired position.", "In accordance with the preferred exemplary implementations, a user can place the one or more implements in the first basin, which can then be filled, or be pre-filled, with a cleaning fluid such as water or soap and water.", "The one or more implements can be left to soak in the first basin for a desired amount of time, to loosen any matter such as food, dirt or stains that is solidly stuck on the one or more implements.", "The user can then select at least one implement from the first basin and place that implement into the second basin to scrub the loosened material from the implement.", "The implement may be “dunked” repeatedly into the second basin, in order to guide the implement along some of the set of bristles, where the bristles forcibly remove the loosened but still-stuck on matter.", "FIG.", "1A is a side view and FIG.", "1B is a top-down view of an implement washing apparatus 100 for soaking and scrubbing one or more implements 101.The implements include food utensils or other tools, such as knives, sticks, scissors, or any other implement that may be soiled with stuck-on matter such as food or dirt, which typically is not fully cleaned by even a dishwasher if available.", "The implement washing apparatus 100 includes a housing 102.The housing can be squared or rounded, and can include one or more side walls and a bottom.", "The one or more side walls and the bottom can be closed and impermeable to fluids such as water.", "Alternatively, selected areas of either the side walls and/or the bottom can be provided with one or more holes or channels to allow fluid and other matter to exit the housing.", "The housing 102 may include, or defines, a first basin 104 and a second basin 106.More basins may also be defined in the housing.", "The first basin 104 includes closed side walls and a closed bottom, and is adapted and arranged to hold a liquid such as water or soap and water, to soak one or more implements 101.The second basin 106 includes side walls and a bottom.", "The side walls of the second basin 106 includes a number of bristles 107 that are attached to the side walls and which are generally directed inwardly to a central area of the second basin 106.In some variations, the bottom of the second basin 106 may also include bristles that extend upwardly.", "The bristles 107 may be part of, for example, a brush, or may be connected to a wire that circumscribes the inside of the side walls of the second basin 106.The housing 102, and therefore the first and second basins 104, 106, may be formed of a water-proof, rigid material such as plastic, PVC, thermoplastic, nylon, acrylic, carbon fiber composite material, hardened rubber, stainless steel, aluminum, or other material.", "The bristles 107 can be formed of any material that is preferably non-abrasive, such as plastic, nylon, of any other non-abrasive yet flexibly rigid material.", "The housing 102 of the implement washing apparatus 100 can include one or more subdividing walls 108 that join and connect the first and second basins 104, 106.The subdividing wall 108 may form at least one of the side walls of the first and/or second basins 104, 106.The subdividing wall 108 may also be formed of a connection of side walls of the first and second basins 104, 106.FIG.", "2A shows a top-down view and FIG.", "2B shows a side view of an alternative implement washing apparatus 200.The implement washing apparatus includes a first basin 204, a second basin 206, and may include a third basin 220 and fourth basin 222.The second basin 206 includes a set of bristles 207 adapted for scrubbing an implement.", "The bristles 207 are shown as extending radially from a rotor that is connected on opposite ends to opposing side walls of the second basin 206.In this arrangement, the second basin 206 can be used to wash and scrub generally planar or wide implements such as plates, bowls, or a number of different implements simultaneously.", "Each of the basins in the implement washing apparatus 200 may be adapted to hold fluid such as water or soap.", "As shown in FIG.", "2A, the third basin 220 includes bristles 221, which may include a first set of bristles that are generally directed inwardly, while a second set of bristles are attached to, and radiating outwardly from, an upward-extending protrusion.", "In this arrangement, implements such as bowls, cups, glasses or mugs may be scrubbed by the bristles 221.The fourth basin 222 may include inwardly directed bristles 223 that are attached to at least some side walls of the fourth basin.", "The implement washing apparatus 200 may further include one or more bridges 208.Each bridge 208 is adapted to connect at least two basins together, as well as provide a downward facing arch for placement on a subdividing wall of a multi-basin sink, for example.", "The bridge 208 and basins may all be formed from one unitary material that makes up housing for the implement washing apparatus 200.FIG.", "3 is a perspective view and FIG.", "4 is a side view an implement washing apparatus 300 in accordance with yet another variation.", "The implement washing apparatus 300 includes a soak basin 302, a scrub basin 304, a rinse basin 306, and a dry basin 308.These basins of the implement washing apparatus 300 can be used sequentially to soak, scrub, rinse and then dry an implement such as a fork, knife, spoon, or other implement.", "The soak basin 302, scrub basin 304, and rinse basin 306 are preferably completely closed except for a top opening, to be able to hold water or other liquid.", "For instance, the soak basin 302 is adapted for holding warm water with soap that soaks an implement and any matter stuck thereon.", "The scrub basin 304 can also hold water or other liquid, but also includes bristles 305 or other scrubbing members which allow an implement to be inserted therein and scrubbed against them.", "The rinse basin 306 preferably holds just water to rinse off any remaining matter or soap suds.", "The dry basin 308 includes a number of holes 310 on a bottom surface to allow draining of any water, liquid or other matter therethrough.", "Implements can therefore be placed in the dry basin 308 where they will dry automatically and without further user manipulation.", "Two or more of the basins 302, 304, 306 and 308 may be connected together by connectors 312.For instance, a subunit can include two basins, and two subunits can be connected together by connectors 312 to form the implement washing apparatus 300.Alternatively, a subunit can include one basin, and two or more basins can be connected together to form the implement washing apparatus 300.Accordingly, an implement washing apparatus 300 may have one to any number of basins.", "In some implementations, each basin can be provided in a common form, i.e.", "with holes 310 and receptacles for holding bristles 305 or other scrubbing members, and the user can configure the common form to hold water by way of a bottom cover that can be placed at the bottom of the basin to cover the holes.", "In this way, each basin can be made from the common faun and tailored with accessories based on user needs or preferences.", "Further, the number of basins used by a user and connected together can be tailored for the environment or sink size, etc.", "FIG.", "5A is a side view and FIG.", "5B is a top-down view of an implement washing apparatus 500 for soaking and scrubbing one or more implements 501, similar to the implementation shown in FIGS.", "1A and 1B.", "However, instead of a subdividing wall between a first basin 504 and a second basin 506, the implement washing apparatus 500 includes a soap basin 510 that is enclosed by opposing side walls 512, top wall 514, opposing end walls 516 and bottom wall 518.In this arrangement, the soap basin 510 forms substantially a hollow rectangular basin, although in other arrangements the soap basin 510 can be rounded, curvilinear or multi-angular.", "The top wall 514 includes an inlet 520 that is closeable by a rubber pump stop 522.The rubber pump stop 522 is compressible, to subject the inner cavity of the soap basin 510 to additional pressure.", "At least one of the opposing side walls 516 includes a set of holes 524 that are sized to inhibit flow of liquid soap therethrough unless the rubber pump stop 522 is compressed and additional pressure is exerted to the inner cavity of the soap basin 510.Since liquid soap generally has a higher viscosity than water in the first and/or second basins 504 and 506, the holes 524 are small, and can range from 0.01 to 10 millimeters.", "The size of the hole is adapted to and consistent with the viscosity of the liquid soap being held in the soap basin 510.The holes 524 are preferably spaced apart at equal increments along the bottom of the side wall(s) 512 of the soap basin 510, to enable dispensing of the liquid soap into the first and/or second basins 504, 506 (illustrated by thin arrows in FIGS.", "5A and 5B) upon compression of the rubber pump stop 522, as indicated by the thick arrow in FIG.", "5A.", "FIG.", "6 is a perspective view of yet another variation of an implement washing apparatus 600, which is similar to the apparatus 300 shown in FIG.", "3, except apparatus 600 includes a soap basin 610 between at least two basins (602, 604) of the two or more basins (602, 604, 606, 608).", "The soap basin 610 is arranged and operates similarly to the basin 510 described above.", "Further, soap basin 610 can be connected to remote basins by soap dispensing channels arranged along the side or bottom, or within the housing 601 of the implement washing apparatus 600.The channels can have a cross-sectional area that is substantially the same as any holes that dispense liquid soap from the soap basin 610 to any other basin.", "Alternatively, other pairs of basins may be separated by a separate soap basin, to provide the implement washing apparatus 600 with two or more soap basins.", "The above-described implement washing apparatuses can be used by a user for one-handed washing of implements, using waterproof, inexpensive and resilient basins.", "The implement washing apparatuses can also save significant amounts of water during the implement washing process, as the rinse cycle can be metered by water in the rinse basin, and food from the implements is easier to rinse off.", "Those having skill the art would recognize that the arrangements illustrated herein, especially the number and arrangement of basins within the apparatuses, are not limited to the specific number and arrangement as described herein.", "Although a few embodiments have been described in detail above, other modifications are possible.", "Other embodiments may be within the scope of the following claims." ] ]
Patent_15872752
[ [ "COUPLING FITTING FOR PIPES", "The invention is directed to a coupling fitting, having a pipeline and having a connector sleeve.", "The pipeline and connector sleeve are each separate parts and are fixedly and non-detachably connected to one another by a connecting ring which can be produced in situ by injection molding plastics material.", "The invention is also directed to a method for making the coupling fitting." ], [ "1.A coupling fitting comprising: a pipeline having an inner diameter and defining an end and an outwardly directed radial annular bead disposed at a predetermined distance from said end; a connecting sleeve pushed onto said pipeline; said connecting sleeve having a first end disposed in the region of said annular bead and an inner wall surface defining a first inner diameter dimensioned so as to cause said annular bead and said inner wall surface to conjointly define a gap therebetween; said connecting sleeve further having a second end defining a second inner diameter which corresponds to said inner diameter of said pipeline; said radial annular bead and said end of said pipeline conjointly defining a transition zone wherein said first inner diameter transitions to said second inner diameter so as to permit said connecting sleeve to be pushed onto said pipeline only so far until said end of said pipeline does not fit any farther into said second diameter of said connecting sleeve; said end of said pipeline and said annular bead together with said coupling sleeve and said pipeline conjointly defining an annular cavity; an elastic annular seal disposed in said annular cavity; an injection molded connecting ring made of plastics material in an injection-molding process and being disposed in a region of said coupling fitting which is axially dimensioned so as to permit said connecting ring to cover over said first end of said connecting sleeve both in a first direction toward said second end of said connecting sleeve as well as in a second direction opposite said first direction to a predetermined dimension; and, the plastics material, because of injection pressure, extending through said gap into said annular cavity up to said elastic annular seal and extending from behind said annular bead in a direction away from said end of said pipeline so as to form a shoulder extending inwardly to said pipeline.", "2.The coupling fitting of claim 1, wherein said connecting sleeve has at least one annular groove into which said plastics material of said connecting ring engages.", "3.The coupling fitting of claim 1, wherein said coupling fitting further comprises a holder having a part thereof embedded in the plastics material of said connecting ring.", "4.The coupling fitting of claim 3, wherein said part projecting into the plastics material of said connecting ring has at least one through hole which is filled with said plastics material.", "5.A method of making a coupling fitting which includes a pipeline having an inner diameter and defining an end and a connecting sleeve, the method comprising the steps of: generating an annular bead on the pipeline disposed at a predetermined distance from the end of the pipeline; pushing an elastic annular seal onto the end of the pipeline so as to cause the annular seal to come to rest between the bead and the end of the pipeline; pushing the connecting sleeve having first and second ends onto the end of the pipeline until the first end comes to rest in the region of said bead so as to cause the outer diameter of the bead and a first inner diameter of the connecting sleeve to conjointly define a gap therebetween and the second end of said connecting sleeve having a second inner diameter corresponding to the inner diameter of the pipeline; the annular bead and the end of the pipeline conjointly defining a transition zone wherein the first inner diameter of said connecting sleeve transitions to the second inner diameter thereof so as to permit the connecting sleeve to be pushed onto the pipeline only so far until the end of the pipeline does not fit any farther into the second diameter of the connecting sleeve; and, injection molding the assembly composed of pipeline end and connecting sleeve to form a connecting ring of plastics material in a region which is axially dimensioned such that the connecting ring covers over the pushed-on first end of the connecting sleeve both in a first direction toward the second end of the connecting sleeve and in a second direction opposite the first direction by a predetermined dimension, wherein the plastics material of the connecting ring is, owing to the injection pressure, pressed through the gap as far as the elastic seal and, secondly, the injected material is pressed around the pipeline behind the bead in a direction away from the pipeline end, such that a shoulder is formed which extends inwardly to the pipeline.", "6.The method of claim 5 comprising the further step of: arranging a holder in the region of the connecting ring to be injection molded, in such a way that a part of the holder projects into the region in which injection molding is to be performed, and said part is encapsulated by the injection-molded plastics material during the injection molding process.", "7.The method of claim 6, wherein part of the holder which projects into the region in which injection molding is to be performed has at least one through hole into which the injection-molded plastics material ingresses during the injection molding process." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Coupling fittings have long been known and used.", "A problem in the case of such fittings may be that the fitting, especially in the case of plug-in connections, must have particular profiles which must be integrally formed on, or attached in fluid-tight fashion in some other way to, the affected end of the line.", "In particular in the case of metallic pipelines, it is common practice for such coupling fittings to be attached by brazing.", "This is however associated with a certain degree of effort and corresponding costs.", "Furthermore, the high temperatures that arise during the brazing process can undesirably adversely affect adjoining components.", "This problem can be circumvented if use is made of fittings composed of plastic, which may for example be adhesively bonded on or else produced in situ by an injection molding process.", "EP 0531709 B1 presents a fitting of this type which is injection-molded onto the end of a pipeline composed of plastic.", "Here, the entire connector part is produced as an injection molding.", "Thus, a relatively large volume of material is required, which leads inter alia to increased cooling times.", "WO 2004/018176 A1 likewise discloses a fitting of the type discussed in the introduction.", "In this case, the plastics pipeline is cohesively connected, by an injection molding process using a plastic, to a connector sleeve which is likewise composed of plastic and which is fitted onto the pipe.", "This principle however functions only with materials which, under the thermal conditions in the injection molding process, fuse together with the injection-molded material at least at the surfaces.", "This greatly restricts the material selection; for example, it is thus not possible to use metallic pipelines.", "Also, extremely exact process control must be ensured, because otherwise there is the risk of leaks forming." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>It is an object of the invention to provide a coupling fitting of the type discussed above such that, with the broadest possible range of usable materials and the least possible material usage, the fitting can be securely and sealingly connected to the pipeline, wherein undesired thermal loading of the components involved and of adjacent components can be avoided.", "The object is achieved in that the fitting has the following features: a radially outwardly directed, encircling bead which is spaced apart from the end of the pipeline by a predetermined dimension; a connector sleeve which is pushed onto the pipeline, the first end of which connector sleeve is arranged in the region of the bead of the pipeline and has a first inner diameter such that a gap is present between the outer diameter of the bead and the first inner diameter of the sleeve, and the second end of which connector sleeve has a second inner diameter which corresponds to the inner diameter of the pipeline, and the first diameter transitions into the second diameter in a transition region between the bead and the end of the pipeline, such that the sleeve can be pushed onto the end of the pipeline only as far as a point at which the end of the pipeline fits no further into the second diameter of the sleeve; an elastic annular seal, which is arranged both between the end of the pipeline and the bead as well as between the pushed-on sleeve and the pipeline; a connecting ring which is arranged in a region which is axially dimensioned such that it covers the pushed-on first end of the sleeve both in the direction of the non-pushed-on second end of the sleeve and in the opposite direction by a predetermined dimension and can be produced in a plastics injection-molding process, wherein the plastics material of the connecting ring can, owing to the injection pressure, be pre-pressed through the gap as far as the elastic seal and, secondly, the injected material can be pressed around the pipeline behind the bead of the pipeline in a direction pointing away from the pipeline end, such that a shoulder can be formed which extends inwardly as far as the pipeline.", "In this way, it is possible to prevent the pipeline from being able to be pulled out of the fitting.", "The injection-molded material pre-pressed against the elastic seal causes the seal to be axially compressed, such that the sealing action between the sleeve and the pipeline can be further intensified.", "In one embodiment of the invention, the pushed-on sleeve has, in the region of the connecting ring, at least one encircling groove into which the material of the connecting ring engages.", "The connection of the connecting ring to the connector sleeve is in this way intensified by means of a positively locking component.", "In one embodiment of the invention, the coupling fitting has a holder which is arranged at least partially in the region of the connecting ring, such that at least a part of the holder is embedded into the material of the connecting ring.", "By means of this arrangement, a holder together with the connecting ring can be produced in one working step with the pipeline.", "In one embodiment of the invention, that part of the holder which projects into the connecting ring has at least one through-hole which is filled with the injection-molded material.", "This arrangement has the advantage that the holder can also be connected in positively locking fashion to the connecting ring.", "The invention furthermore relates to a method for producing a coupling fitting, having a pipeline and having a connector sleeve.", "In this case, the invention is based on the object of producing the connection discussed in the introduction so as to be secure and sealed in the simplest possible manner and with the least possible material usage, wherein undesired thermal loading of the components involved and of adjacent components is avoided.", "The object is achieved in that the connection is made by the following working steps: producing an encircling bead on the pipeline, wherein the bead is spaced apart from the end of the pipeline by a predetermined dimension; pushing an elastic, ring-shaped seal onto the end of the pipeline such that the seal comes to lie between the bead and the end of the pipeline; pushing a sleeve onto the end of the pipeline such that the first end of the sleeve comes to lie in the region of the bead of the pipeline and has a first inner diameter such that a gap is formed between the outer diameter of the bead and the first inner diameter of the sleeve, and the second end of which sleeve has a second inner diameter which corresponds to the inner diameter of the pipeline, and the first diameter transitions into the second diameter in a transition region between the bead and the end of the pipeline, such that the sleeve can be pushed onto the end of the pipeline only as far as a point at which the end of the pipeline fits no further into the second diameter of the sleeve; encapsulating the assembly composed of pipeline end and sleeve to form a connecting ring in a region which is axially dimensioned such that the connecting ring covers the pushed-on first end of the sleeve both in the direction of the non-pushed-on second end of the sleeve and in the opposite direction by a predetermined dimension and is produced in a plastics injection-molding process, wherein the material of the connecting ring is, owing to the injection pressure, pressed through the gap as far as the elastic seal and, secondly, the injected material is pressed around the pipeline behind the bead of the pipeline in a direction pointing away from the pipeline end, such that a shoulder is formed which extends inwardly as far as the pipeline.", "In this way, an inwardly pointing shoulder of the encapsulation forms behind the bead of the pipeline, which shoulder prevents the pipeline from being able to be pulled out of the fitting.", "The inflow of the injection-molded material against the elastic seal causes the seal to be axially compressed, such that the sealing action between the sleeve and the pipeline is further intensified.", "In one embodiment of the invention, the pushed-on sleeve has, in the region of the encapsulation, at least one encircling groove into which the injection-molded material flows during the injection-molding process.", "Thus, positive locking is generated between the sleeve and the solidified injection-molded material, which positive locking improves the reliability with which the sleeve and the pipeline are prevented from being pulled apart.", "In one embodiment of the invention, the method furthermore comprises the following step: arranging a holder in the region of the connecting ring to be encapsulated, in such a way that a part of the holder projects into the region in which injection molding is to be performed, and the part is encapsulated by the injection-molded material during the injection molding process.", "This arrangement has the advantage that a holder does not have to be separately attached.", "In one embodiment of the invention, that part of the holder which projects into the region in which injection molding is to be performed has at least one through-hole into which the injection-molded material ingresses during the injection molding process.", "In this way, the holder is also connected in positively locking fashion to the connecting ring." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation application of international patent application PCT/EP2016/054500, filed Mar.", "3, 2016, designating the United States and claiming priority from German application 10 2015 213 223.4, filed Jul.", "15, 2015, and the entire content of both applications is incorporated herein by reference.", "FIELD OF THE INVENTION The invention relates to a coupling fitting, having a pipeline and having a connector sleeve.", "BACKGROUND OF THE INVENTION Coupling fittings have long been known and used.", "A problem in the case of such fittings may be that the fitting, especially in the case of plug-in connections, must have particular profiles which must be integrally formed on, or attached in fluid-tight fashion in some other way to, the affected end of the line.", "In particular in the case of metallic pipelines, it is common practice for such coupling fittings to be attached by brazing.", "This is however associated with a certain degree of effort and corresponding costs.", "Furthermore, the high temperatures that arise during the brazing process can undesirably adversely affect adjoining components.", "This problem can be circumvented if use is made of fittings composed of plastic, which may for example be adhesively bonded on or else produced in situ by an injection molding process.", "EP 0531709 B1 presents a fitting of this type which is injection-molded onto the end of a pipeline composed of plastic.", "Here, the entire connector part is produced as an injection molding.", "Thus, a relatively large volume of material is required, which leads inter alia to increased cooling times.", "WO 2004/018176 A1 likewise discloses a fitting of the type discussed in the introduction.", "In this case, the plastics pipeline is cohesively connected, by an injection molding process using a plastic, to a connector sleeve which is likewise composed of plastic and which is fitted onto the pipe.", "This principle however functions only with materials which, under the thermal conditions in the injection molding process, fuse together with the injection-molded material at least at the surfaces.", "This greatly restricts the material selection; for example, it is thus not possible to use metallic pipelines.", "Also, extremely exact process control must be ensured, because otherwise there is the risk of leaks forming.", "SUMMARY OF THE INVENTION It is an object of the invention to provide a coupling fitting of the type discussed above such that, with the broadest possible range of usable materials and the least possible material usage, the fitting can be securely and sealingly connected to the pipeline, wherein undesired thermal loading of the components involved and of adjacent components can be avoided.", "The object is achieved in that the fitting has the following features: a radially outwardly directed, encircling bead which is spaced apart from the end of the pipeline by a predetermined dimension; a connector sleeve which is pushed onto the pipeline, the first end of which connector sleeve is arranged in the region of the bead of the pipeline and has a first inner diameter such that a gap is present between the outer diameter of the bead and the first inner diameter of the sleeve, and the second end of which connector sleeve has a second inner diameter which corresponds to the inner diameter of the pipeline, and the first diameter transitions into the second diameter in a transition region between the bead and the end of the pipeline, such that the sleeve can be pushed onto the end of the pipeline only as far as a point at which the end of the pipeline fits no further into the second diameter of the sleeve; an elastic annular seal, which is arranged both between the end of the pipeline and the bead as well as between the pushed-on sleeve and the pipeline; a connecting ring which is arranged in a region which is axially dimensioned such that it covers the pushed-on first end of the sleeve both in the direction of the non-pushed-on second end of the sleeve and in the opposite direction by a predetermined dimension and can be produced in a plastics injection-molding process, wherein the plastics material of the connecting ring can, owing to the injection pressure, be pre-pressed through the gap as far as the elastic seal and, secondly, the injected material can be pressed around the pipeline behind the bead of the pipeline in a direction pointing away from the pipeline end, such that a shoulder can be formed which extends inwardly as far as the pipeline.", "In this way, it is possible to prevent the pipeline from being able to be pulled out of the fitting.", "The injection-molded material pre-pressed against the elastic seal causes the seal to be axially compressed, such that the sealing action between the sleeve and the pipeline can be further intensified.", "In one embodiment of the invention, the pushed-on sleeve has, in the region of the connecting ring, at least one encircling groove into which the material of the connecting ring engages.", "The connection of the connecting ring to the connector sleeve is in this way intensified by means of a positively locking component.", "In one embodiment of the invention, the coupling fitting has a holder which is arranged at least partially in the region of the connecting ring, such that at least a part of the holder is embedded into the material of the connecting ring.", "By means of this arrangement, a holder together with the connecting ring can be produced in one working step with the pipeline.", "In one embodiment of the invention, that part of the holder which projects into the connecting ring has at least one through-hole which is filled with the injection-molded material.", "This arrangement has the advantage that the holder can also be connected in positively locking fashion to the connecting ring.", "The invention furthermore relates to a method for producing a coupling fitting, having a pipeline and having a connector sleeve.", "In this case, the invention is based on the object of producing the connection discussed in the introduction so as to be secure and sealed in the simplest possible manner and with the least possible material usage, wherein undesired thermal loading of the components involved and of adjacent components is avoided.", "The object is achieved in that the connection is made by the following working steps: producing an encircling bead on the pipeline, wherein the bead is spaced apart from the end of the pipeline by a predetermined dimension; pushing an elastic, ring-shaped seal onto the end of the pipeline such that the seal comes to lie between the bead and the end of the pipeline; pushing a sleeve onto the end of the pipeline such that the first end of the sleeve comes to lie in the region of the bead of the pipeline and has a first inner diameter such that a gap is formed between the outer diameter of the bead and the first inner diameter of the sleeve, and the second end of which sleeve has a second inner diameter which corresponds to the inner diameter of the pipeline, and the first diameter transitions into the second diameter in a transition region between the bead and the end of the pipeline, such that the sleeve can be pushed onto the end of the pipeline only as far as a point at which the end of the pipeline fits no further into the second diameter of the sleeve; encapsulating the assembly composed of pipeline end and sleeve to form a connecting ring in a region which is axially dimensioned such that the connecting ring covers the pushed-on first end of the sleeve both in the direction of the non-pushed-on second end of the sleeve and in the opposite direction by a predetermined dimension and is produced in a plastics injection-molding process, wherein the material of the connecting ring is, owing to the injection pressure, pressed through the gap as far as the elastic seal and, secondly, the injected material is pressed around the pipeline behind the bead of the pipeline in a direction pointing away from the pipeline end, such that a shoulder is formed which extends inwardly as far as the pipeline.", "In this way, an inwardly pointing shoulder of the encapsulation forms behind the bead of the pipeline, which shoulder prevents the pipeline from being able to be pulled out of the fitting.", "The inflow of the injection-molded material against the elastic seal causes the seal to be axially compressed, such that the sealing action between the sleeve and the pipeline is further intensified.", "In one embodiment of the invention, the pushed-on sleeve has, in the region of the encapsulation, at least one encircling groove into which the injection-molded material flows during the injection-molding process.", "Thus, positive locking is generated between the sleeve and the solidified injection-molded material, which positive locking improves the reliability with which the sleeve and the pipeline are prevented from being pulled apart.", "In one embodiment of the invention, the method furthermore comprises the following step: arranging a holder in the region of the connecting ring to be encapsulated, in such a way that a part of the holder projects into the region in which injection molding is to be performed, and the part is encapsulated by the injection-molded material during the injection molding process.", "This arrangement has the advantage that a holder does not have to be separately attached.", "In one embodiment of the invention, that part of the holder which projects into the region in which injection molding is to be performed has at least one through-hole into which the injection-molded material ingresses during the injection molding process.", "In this way, the holder is also connected in positively locking fashion to the connecting ring.", "BRIEF DESCRIPTION OF THE DRAWING The invention will now be described with reference to the single figure of the drawing (FIG.", "1) which shows a coupling fitting according to the invention in longitudinal section.", "DESCRIPTION OF THE PREFERRED EMBODIMENTS OF THE INVENTION In FIG.", "1, the coupling fitting 1 has a pipeline 2 with an inner diameter 3 and has an end contour 4 and an encircling bead 5.The coupling 1 further includes a connector sleeve 6 with a first inner diameter 8 and a second inner diameter 7.The first inner diameter 8 is dimensioned such that a gap 9 exists between the encircling bead 5 and the connector sleeve 6.Between the end contour 4, the bead 5 and the inner diameter 8 of the connector sleeve 6, there is arranged an elastic ring seal 10 which seals off the pipeline 2 against the sleeve 6.The sleeve 6 has an encircling groove 11 on its outer circumference.", "In the end region 12 of the sleeve 6, which end region is pushed onto the pipeline 2 over the bead 5, a connecting ring 13 composed of plastics material is injection-molded thereon.", "The connecting ring 13 completely covers the end region 12 of the sleeve 6 in an axial direction.", "The plastics material of the connecting ring 13 has, during the injection molding process, ingressed through the gap 9 into a cavity 14.The cavity 14 is formed by the elastic seal 10, the inner diameter 8 of the sleeve 6 and the pipeline 2.Owing to the injection-molding pressure, the seal 10 has been compressed slightly, which gives rise to an increase in the contact pressure of the seal 10 and thus an improvement of the sealing action.", "The connecting ring 13 furthermore engages around the outer circumference of the sleeve 6, wherein the material is also pressed into the groove 11.The connecting ring 13 furthermore extends around the end region 12 of the sleeve 6 such that, behind the end 12 of the sleeve 6 in the direction of the pipeline 2, the connecting ring 13 forms a shoulder 15 which extends as far as the pipeline 2.Here, the bead 5 is also enclosed or enveloped.", "The connecting ring 13 thus prevents the inadvertent separation of sleeve 6 and pipeline 2 both in positively locking fashion, by engagement into the groove 11 and behind the bead 5, and by frictional engagement between the sleeve 6 and pipeline 2.It is understood that the foregoing description is that of the preferred embodiments of the invention and that various changes and modifications may be made thereto without departing from the spirit and scope of the invention as defined in the appended claims.", "LIST OF REFERENCE SIGNS Part of the Description 1 Coupling fitting 2 Pipeline 3 Inner diameter of the pipeline 2 4 End contour of the pipeline 2 5 Encircling bead of the pipeline 2 6 Connector sleeve/sleeve 7 Second inner diameter of the sleeve 6 8 First inner diameter of the sleeve 6 9 Gap 10 Elastic ring seal/seal 11 Encircling groove of the sleeve 6 12 End region of the sleeve 6 13 Connecting ring 14 Cavity 15 Shoulder of the sleeve 6" ] ]
Patent_15872760
[ [ "COMPOSITES AND COMPOSITIONS FOR THERAPEUTIC USE AND METHODS OF MAKING AND USING THE SAME", "Disclosed herein are embodiments of composites and compositions that can be used for therapeutic applications in vivo and/or in vitro.", "The disclosed composites can comprise cores having magnetic nanoparticles, quantum dots, or combinations thereof and zwitterionic polymeric coatings that facilitate solubility and bioconjugation.", "The compositions disclosed herein can comprise the composites and one or more biomolecules, drugs, or combinations thereof.", "Also disclosed herein are methods of making the composites, composite components, and methods of making quantum dots for use in the composites." ], [ "1.A composite, comprising: a core comprising one or more magnetic nanoparticles, one or more quantum dots, or a combination thereof; and a zwitterionic polymeric coating defining the core and comprising a zwitterionic polymer having a structure satisfying a formula wherein each R1 independently is hydrogen or aliphatic; each R2 is —C(O)Z, wherein Z is hydroxyl, ether, amine, thiol, or thioether; each R3 independently is amide-aliphatic-amine, amide-aliphatic-amine-aliphatic-carboxylate, amide-aliphatic-amine-aliphatic-sulfonate, or amide-aliphatic-thiol; p is an integer selected from zero to 5; q is an integer selected from zero or 1; and each of a and b independently is an integer selected from 1 to 200.2.The composite of claim 1, wherein the zwitterionic polymeric coating comprises a zwitterionic polymer having a structure satisfying a formula selected from wherein each R1 independently is hydrogen or aliphatic; each of X1, X2, X3, X4, and X5 independently is NRb, N(Rb)2+, oxygen, or sulfur, wherein each Rb independently is hydrogen, aliphatic, heteroaliphatic, aryl, or heteroaryl; each of A1, A2, A3, A4, and A5 independently is aliphatic or heteroaliphatic; each of Y1, Y2, and Y3 independently is amine, thiol, carboxylate or sulfonate; each Z independently is hydroxyl, ether, amine, thiol, or thioether; n is an integer selected from 1 to 200; each m is an integer selected from 0 to 3; each p independently is an integer selected from zero to 5; each of a, b, and c independently is an integer selected from 1 to 200.3.The composite of claim 1, wherein each R1 independently is hydrogen, alkyl, alkenyl, or alkynyl; each of X1, X2, X3, X4, and X5 independently is NRb, N(Rb)2+, oxygen, or sulfur, wherein each Rb independently is hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, phenyl, naphthyl, or pyridinyl; each of A1, A2, A3, A4, and A5 independently is alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, or heteroalkynyl; each of Y1 and Y2 independently is carboxylate or sulfonate and Y3 is thiol; each Z is hydroxyl; and m is 1.4.The composite of claim 1, wherein the zwitterionic polymeric coating comprises a zwitterionic polymer have a structure selected from 5.The composite of claim 1, wherein the core comprises at least one magnetic nanoparticle and at least one quantum dot.", "6.The composite of claim 1, wherein the core is doped with a metal selected from Cu, Ag, Au, Mn, Zn, or combinations thereof and wherein the core is doped with greater than 0 mol % to 10 mol % of the metal.", "7.The composite of claim 6, wherein the core is a quantum dot core and the quantum dot core comprises a ZnS or a chloride shell.", "8.The composite of claim 1, wherein the magnetic nanoparticle is MnFe2O4, Fe3O4, CoFe2O4, FePt or a combination thereof.", "9.The composite of claim 1, wherein the core comprises a combination of MnFe2O4 nanoparticles and an AgInS2 quantum dot, a CuInS2 quantum dot, or a combination thereof.", "10.The composite of claim 1, comprising: a core comprising a combination of MnFe2O4 nanoparticles and CuInS2 quantum dots, AgInS2 quantum dots, or both CuInS2 quantum dots, AgInS2 quantum dots; and a zwitterionic polymeric coating comprising a zwitterionic polymer having a structure selected from 11.The composite of claim 10, wherein the core further comprises a dopant selected from Cu, Ag, Au, Mn, Zn, or combinations thereof, a ZnS or chloride shell, or both the dopant and the ZnS or chloride shell.", "12.A composition comprising: a composite having a core comprising one or more magnetic nanoparticles, one or more quantum dots, or a combination thereof and a zwitterionic polymeric coating comprising a zwitterionic polymer having a structure satisfying a formula wherein each R1 independently is selected from hydrogen or aliphatic; each R2 is —C(O)Z, wherein Z is selected from hydroxyl, ether, amine, thiol, or thioether; each R3 independently is selected from amide-aliphatic-amine, amide-aliphatic-amine-aliphatic-carboxylate, amide-aliphatic-amine-aliphatic-sulfonate, or amide-aliphatic-thiol; p is an integer selected from zero to 5; q is an integer selected from zero or 1; and each of a and b independently is an integer selected from 1 to 200; and a biomolecule, a drug, or a combination thereof.", "13.The composition of claim 12, wherein the biomolecule is chemically conjugated to the composite through the zwitterionic polymeric coating or through a carboxylate group of the zwitterionic polymeric coating.", "14.The composition of claim 13, wherein the carboxylate group of the zwitterionic polymeric coating is further chemically bound to a linker, wherein the linker is also chemically bound to the biomolecule.", "15.The composition of claim 12, wherein the biomolecule is selected from chlorotoxin, avidin, biotin, folic acid, arginylglycylaspartic acid, or combinations thereof.", "16.The composition of claim 12, wherein the drug is encapsulated within the zwitterionic polymeric coating and is selected from doxorubicin, daunorubicin, epirubicin, idarubicin, or a combination thereof.", "17.A method of making the composite of claim 1, comprising: combining, to form a mixture, a solution comprising the one or more magnetic nanoparticles, the one or more quantum dots, or the combination thereof with a solution of the zwitterionic polymer; dispersing the mixture into water using sonication to form a dispersed composition; and isolating the composite from the dispersed composition.", "18.A method of making a quantum dot, comprising: combining a Group 11 metal precursor with a Group 13 metal precursor, one or more ligands, a solvent, or a combination thereof to form a precursor mixture; and heating the precursor mixture to a temperature sufficient to facilitate formation of the quantum dot.", "19.The method of claim 18, wherein the Group 11 metal precursor is a copper-containing precursor, a silver-containing precursor, or a combination thereof and the temperature ranges from 150° C. to 200° C. 20.A method for imaging cells, comprising: contacting a cell with the composite of claim 1; and detecting cellular update and/or the location of the composite in the cell.", "21.A method of delivering a therapeutic drug to a subject, comprising contacting the subject with a therapeutically effective amount of a composition comprising the therapeutic drug and the composite of claim 1." ], [ "<SOH> BACKGROUND <EOH>Magnetofluorescent nanoparticles enabling simultaneous fluorescence labeling and magnetic field assisted separation, sorting, heating or imaging are gaining momentum for biomedical applications at the cellular, tissue or anatomical levels.", "For this reason, research approaches have been reported on the controlled synthesis of magnetofluorescent nanoparticles regarding their size, shape, composite and surface properties.", "To achieve colloidal stability and biocompatibility for various in vitro or in vivo applications, the hydrophilic shell of these type of magnetofluorescent nanoparticles are usually formed by anti-fouling poly(ethylene glycol) (PEG) chains.", "Zwitterion-coating approaches also have been developed for individual cadmium-based quantum dots or AuNPs but not for magnetofluorescent compounds.", "These approaches mainly involve the coupling of zwitterions with thiol ligands, such as dihydrolipoic acid.", "These coupled ligands are further exchanged with native hydrophobic ligands (trioctylphosphine oxide) to form thiol-bound zwitterionic quantum dots through the high binding affinity of thiols to Zn or Au atoms on quantum dot or AuNP surface.", "Significant efforts are still needed to develop high quality quantum dots into broader biomedical applications especially for in vitro or in vivo sensing/imaging and drug delivery.", "There exists a need in the art for facile, scalable methods of making chalcopyrite quantum dots that are compatible for use in magnetofluorescent composites comprising nanoparticles.", "There also exists a need in the art for composites comprising zwitterionic coatings that can be used to produce composites capable for biomedical use and/or coupling to biomolecules." ], [ "<SOH> SUMMARY <EOH>Disclosed herein are embodiments of composites comprising a core comprising one or more nanoparticles (such as magnetic nanoparticles), one or more quantum dots, or a combination thereof, and a zwitterionic polymeric coating comprising a zwitterionic polymer having any one of the formulas and/or structures disclosed herein.", "In some embodiments, the core comprises at least one magnetic nanoparticle and at least one quantum dot.", "Also disclosed herein are embodiments of compositions comprising a composite having a core comprising one or more magnetic nanoparticles, one or more quantum dots, or a combination thereof, a zwitterionic polymeric coating defining the core, and a biomolecule, a drug, or a combination thereof.", "Also disclosed herein are embodiments of methods for making the composites, methods of making quantum dots, and methods of using the disclosed composites for visualizing uptake/binding in cells or tissues and/or treating subjects.", "The foregoing and other objects, features, and advantages of the present disclosure will become more apparent from the following detailed description, which proceeds with reference to the accompanying figures." ], [ "CROSS REFERENCE TO RELATED APPLICATION This application claims the benefit of U.S.", "Provisional Application No.", "62/569,291, filed on Oct. 6, 2017; and is a continuation-in-part of PCT Application No.", "PCT/US2016/042613, filed on Jul.", "15, 2016, which claims the benefit of U.S.", "Provisional Application No.", "62/203,325, filed Aug. 10, 2015, and U.S.", "Provisional Application No.", "62/194,122, filed on Jul.", "17, 2015; each of these applications is incorporated herein by reference in its entirety.", "ACKNOWLEDGMENT OF GOVERNMENT SUPPORT This invention was made with government support under Contract No.", "1P20GM103650 awarded by the National Institutes of Health.", "The government has certain rights in the invention.", "FIELD The present disclosure concerns embodiments of composites and compositions comprising nanoparticle and/or quantum dot cores, and zwitterionic polymeric coatings.", "Also disclosed herein are embodiments of methods of making components used in the composites and compositions, as well as methods of making and using the composites and compositions.", "BACKGROUND Magnetofluorescent nanoparticles enabling simultaneous fluorescence labeling and magnetic field assisted separation, sorting, heating or imaging are gaining momentum for biomedical applications at the cellular, tissue or anatomical levels.", "For this reason, research approaches have been reported on the controlled synthesis of magnetofluorescent nanoparticles regarding their size, shape, composite and surface properties.", "To achieve colloidal stability and biocompatibility for various in vitro or in vivo applications, the hydrophilic shell of these type of magnetofluorescent nanoparticles are usually formed by anti-fouling poly(ethylene glycol) (PEG) chains.", "Zwitterion-coating approaches also have been developed for individual cadmium-based quantum dots or AuNPs but not for magnetofluorescent compounds.", "These approaches mainly involve the coupling of zwitterions with thiol ligands, such as dihydrolipoic acid.", "These coupled ligands are further exchanged with native hydrophobic ligands (trioctylphosphine oxide) to form thiol-bound zwitterionic quantum dots through the high binding affinity of thiols to Zn or Au atoms on quantum dot or AuNP surface.", "Significant efforts are still needed to develop high quality quantum dots into broader biomedical applications especially for in vitro or in vivo sensing/imaging and drug delivery.", "There exists a need in the art for facile, scalable methods of making chalcopyrite quantum dots that are compatible for use in magnetofluorescent composites comprising nanoparticles.", "There also exists a need in the art for composites comprising zwitterionic coatings that can be used to produce composites capable for biomedical use and/or coupling to biomolecules.", "SUMMARY Disclosed herein are embodiments of composites comprising a core comprising one or more nanoparticles (such as magnetic nanoparticles), one or more quantum dots, or a combination thereof, and a zwitterionic polymeric coating comprising a zwitterionic polymer having any one of the formulas and/or structures disclosed herein.", "In some embodiments, the core comprises at least one magnetic nanoparticle and at least one quantum dot.", "Also disclosed herein are embodiments of compositions comprising a composite having a core comprising one or more magnetic nanoparticles, one or more quantum dots, or a combination thereof, a zwitterionic polymeric coating defining the core, and a biomolecule, a drug, or a combination thereof.", "Also disclosed herein are embodiments of methods for making the composites, methods of making quantum dots, and methods of using the disclosed composites for visualizing uptake/binding in cells or tissues and/or treating subjects.", "The foregoing and other objects, features, and advantages of the present disclosure will become more apparent from the following detailed description, which proceeds with reference to the accompanying figures.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a combined photoluminescence spectrum of AgInS2 (AIS) quantum dots and AIS/ZnS quantum dots where the inset shows a digital photograph of AIS quantum dots and AIS/ZnS quantum dots in organic solvents exposed under a UV laser beam.", "FIG.", "2 is a combined Fourier Transform Infrared (FT-IR) spectrum of a representative polymer precursor (“PMAO”), a representative polymer intermediate (“PMAO-DMAPA”), and a zwitterionic polymer (“PMAO-CB-SB”).", "FIG.", "3 is a combined FT-IR spectra of amidosulfobetaine-16 (“ASB-16”) (with sulfobetaine) and N-dodecyl-N,N-(dimethylammonio)butyrate (“DDMAB”) (with carboxybetaine).", "FIG.", "4 is a graph of normalized photoluminescence intensity (a.u.)", "as a function of wavelength (nm) illustrating representative and normalized photoluminescence intensity of CIS quantum dots in the time course of growth at 240° C. FIG.", "5 is a combined 1H-NMR spectrum illustrating NMR spectra of a representative polymer precursor (“PMAO”), a representative polymer intermediate (“PMAO-DMAPA”), and a zwitterionic polymer (“PMAO-CB-SB”).", "FIGS.", "6A-6C illustrate TEM and EDX images of representative composite cores; FIG.", "6A is a TEM image of a representative composite core having a nanoparticle to quantum dot ratio of 1:4; FIG.", "6B is a zoomed image of a single composite core illustrating both spherical and irregular particle shapes representing nanoparticles and quantum dots; and FIG.", "6C is an EDX spectrum.", "FIGS.", "7A and 7B are graphs illustrating results obtained from analysis of representative composites; FIG.", "7A is a combined photoluminescence spectrum of hydrophobic quantum dots in organic solvent and water-soluble composites as disclosed herein; FIG.", "7B is a graph of R2 parameters of composites disclosed herein versus (Mn+Fe) concentration (the slope r2 of each curve=R2/[(Mn+Fe) concentration]), wherein the inset image is a representative magnetic resonance image of zwitterionic magnetofluorescent nanoparticles and zwitterionic magnetic nanoparticles.", "FIGS.", "8A and 8B illustrate results obtained from analysis of representative composites; FIG.", "8A is a combined spectrum illustrating photoluminescence of hydrophobic quantum dots in THF and water-soluble composites; and FIG.", "8B is a graph of R2 parameters of composites versus (Mn+Fe) concentration (the slope r2 of each curve=R2/[(Mn+Fe) concentration]), wherein the inset image is a representative magnetic resonance image of composites fabricated with the nanoparticle to quantum dot mass ratios of 1:0, 1:1, 1:2, and 1:4.FIG.", "9 illustrates the UV-Vis absorbance spectra of quantum dots in THF and representative water-soluble composites.", "FIG.", "10 is a bar graph of fluorescence stability of representative composites in PBS solutions at pH values ranging from 4-9, which illustrates the colloidal stability of the composites in aqueous solutions.", "FIG.", "11 is a bar graph of fluorescence stability of representative composites in water at 4° C. FIG.", "12 is a bar graph of long-term stability of representative composites in water at 4° C. FIGS.", "13A and 13B are graphs illustrating cell viability cell treated with representative composites disclosed herein illustrating that the composites have no significant effects on cell cytotoxicity; FIG.", "13A shows cell viability of U-87 MG cells treated with composites at different concentrations over 24 hours; and FIG.", "13B shows cell viability of HEK-293 cells treated with zwitterionic magnetofluorescent nanoparticles at different concentrations over 24 hours.", "FIG.", "14 is a graph illustrating cell viability of U-87 MG cell and HEK-293 cells treated with representative composites at difference concentrations over 24 hours.", "FIG.", "15 is a bar graph illustrating the fluorescence responses to biotinylated magnetic microbeads after incubation with serial dilutions of non-conjugated and Neutravidin-conjugated composites from their stock suspensions.", "FIGS.", "16A-16E illustrate results obtained for representative composites disclosed herein; FIG.", "16A is a confocal image illustrating cellular uptake/internalization of cyclophosphamide (“CTX”)-conjugated composites by U-87 cells; FIG.", "16B is a confocal image illustrating cellular uptake/internalization of non-conjugated composites by U-87 cells; FIG.", "16C is a confocal image illustrating cellular uptake/internalization of CTX-conjugated composites by HEK-293; FIG.", "16D is a confocal image illustrating cellular uptake/internalization of non-conjugated composites by HEK-293 cells; and FIG.", "16E is a bar graph of micelle photoluminescence intensity as a function of composite concentration illustrating the fluorescent intensity per unit area of cytoplasm for U-87 and HEK-293 cells incubated with CTX- and non-conjugated composites with different concentrations.", "FIGS.", "17A-17D are confocal images at different channels and their overlays demonstrating the cellular uptake/internalization of CTX-conjugated composites by U-87 (FIG.", "17A) and HEK-293 (FIG.", "17C) and non-conjugated composites under the same concentration of particles by U-87 (FIG.", "17B) and HEK-293 (FIG.", "17D).", "FIG.", "18 illustrates the evolution of the photoluminescence spectra of a representative quantum dot used in composites described herein during the time course of growth at 170° C. FIGS.", "19A-19C are images illustrating results obtained from TEM and EDX analysis of representative quantum dots made using methods described herein; FIG.", "19A is a TEM image of a representative quantum dot; FIG.", "19B is a high resolution TEM image of a representative quantum dot; and FIG.", "19C is an EDX spectrum of a representative quantum dot.", "FIG.", "20 is an EDX spectrum of a representative quantum dot made using a thermal decomposition synthesis embodiment.", "FIG.", "21 illustrates XRD patterns for representative shell-coated and shell-free quantum dots; diffraction peaks of tetragonal AgInS2 and cubic ZnS are shown as references.", "FIG.", "22 illustrates photoluminescence spectra of representative quantum dots made using a disclosed thermal decomposition method embodiment.", "FIG.", "23 illustrates UV-Vis absorption spectra representative quantum dots synthesized at different ratios (1:1, 1:2 and 1:4), wherein the inset provides digital photograph of the quantum dots under room lights.", "FIGS.", "24A and 24B are digital photographs of representative quantum dots made using a disclosed thermal decomposition method embodiment; FIG.", "24A illustrates quantum dots made using a Ag:In molar ratio of Ag:In=1:1; and FIG.", "24B illustrates quantum dots made using a Ag:In molar ratio of Ag:In=1:2.FIGS.", "25A and 25B are graphs illustrating the photostability of AIS quantum dots (FIG.", "25A) and AIS/ZnS quantum dots (FIG.", "25B), wherein quantum dots in organic solvents were under continuous exposure of a 365 nm UV lamp for 120 minutes and their photoluminescence was measured every 30 minutes.", "FIG.", "26 is a schematic illustration of quantum dot-loaded micelles comprising quantum dots made using thermal decomposition method embodiments disclosed herein.", "FIG.", "27 illustrates photoluminescence spectra of representative quantum dots in hexane and quantum dot micelles in water, wherein the insets are the hydrodynamic size distribution of the resulting quantum dot-micelles measured by DSL (top) and the corresponding TEM image of the quantum dot-micelles.", "FIGS.", "28A-28C are TEM and EDX images obtained for representative quantum dots; FIG.", "28A is a TEM image of an individual quantum dot-micelle; FIG.", "28B is a high resolution TEM image of an individual quantum dot-micelle; and FIG.", "28C is an EDX spectrum of quantum dot-micelles.", "FIG.", "29 illustrates FT-IR spectra of representative quantum dots, PLGA-PEG, CTX, quantum dot-micelles, and CTX-conjugated quantum dot-micelles.", "FIGS.", "30A-30C illustrate results obtained from analysis of representative quantum dots made using a disclosed thermal decomposition method embodiment; FIG.", "30A shows confocal images demonstrating the cellular uptake/internalization of CTX-conjugated quantum dot-micelles (100 times diluted from stock) by U-87 cells; FIG.", "30B shows confocal images presenting the quenching effect of 1,10-phenanthroline on the uptake/internalization; and FIG.", "30C shows quantitative data indicating the cellular uptake/internalization and the quenching effect under the different concentrations or dilutions of CTX-conjugated quantum dot-micelles (100-800 times dilutions).", "FIGS.", "31A-31E illustrate results obtained from analysis of representative quantum dots made using a disclosed thermal decomposition methods embodiment; FIG.", "31A is an overlaid confocal image of U-87 cells after incubation with CTX-conjugated micelles comprising the quantum dots; FIG.", "31B is an overlaid confocal image of U-87 cells after incubation with non-conjugated micelles comprising the quantum dots; FIG.", "31C is an overlaid confocal image of HEK-293 cells after incubating with CTX-conjugated micelles comprising the quantum dots; FIG.", "31D is an overlaid confocal image of HEK-293 cells after incubating with non-conjugated micelles comprising the quantum dots; and FIG.", "31E illustrates the fluorescent intensity per unit area of cytoplasm for U-87 and HEK-293 cells incubated with CTX-conjugated and non-conjugated AIS/ZnS micelles.", "FIG.", "32 provides an exemplary schematic of a representative method of making micelles comprising the polymeric coatings disclosed herein.", "FIG.", "33 is a schematic diagram illustrating a representative composite and use of the composite to administer drug molecules to a cell.", "FIGS.", "34A and 34B each are TEM images of a representative quantum dot made using a disclosed thermal decomposition method embodiment.", "FIGS.", "35A and 35B show results obtained from analyzing representative doped quantum dots; FIG.", "35A is a graph of photoluminescence intensity (a.u.)", "as a function of wavelength (nm) showing the effect of Cu-dopant concentrations on photoluminescence for surface-doped quantum dots, wherein the inset data plot shows that the evolution of photoluminescence spectra of non-doped AIS nanocrystals is not significant in the time course of growth; and FIG.", "35B shows the absorption spectra of the copper-doped quantum dots with different Cu initial concentrations.", "FIGS.", "36A and 36B show results obtained from time course analysis of Cu-doped quantum dots; FIG.", "36A shows the evolution of photoluminescence spectra of 3.33% Cu:AIS quantum dots in the time course of reaction using a surface doping approach, wherein the inset is the evolution of photoluminescence spectra of Cu:AIS quantum dots prepared through a homogenous reaction; FIG.", "36B shows the temporal evolution of absorption spectra of 3.33% Cu:AIS quantum dots.", "FIGS.", "37A-37D show characterization data of representative Cu-doped quantum dots disclosed herein; FIG.", "37A shows XRD patterns for AIS, 1.67% Cu:AIS and 6.67% Cu:AIS quantum dots; FIG.", "37B shows TEM and high resolution TEM (insets) images of AIS quantum dots; FIG.", "37C shows TEM and high resolution TEM (insets) images of 1.67% Cu:AIS quantum dots; and FIG.", "37D shows TEM and high resolution TEM (insets) images of 6.67% Cu:AIS quantum dots.", "FIGS.", "38A-38D show results obtained from characterization analysis of representative embodiments of Cu-doped core quantum dots and Cu-doped core/shell quantum dots; FIG.", "38A shows digital images of Cu:AIS and Cu:AIS/ZnS quantum dots suspended in organic solvents under a UV lamp; FIG.", "38B is a combined absorption spectrum of photoluminescence and absorption spectra of the core and core/shell quantum dots; FIG.", "38C is shows the XRD patterns of 6.67% Cu:AIS and Cu:AIS/ZnS quantum dots; FIG.", "38D shows TEM and high resolution TEM (inset) images of 6.67% Cu:AIS/ZnS quantum dots.", "FIGS.", "39A and 39B are photoluminescence decay curves showing the photoluminescence decay for representative Cu:AIS quantum dots (FIG.", "39A) and Cu:AIS/ZnS quantum dots (FIG.", "39B).", "FIG.", "40 is a graph of cell viability (%) as a function of composite (referred to as “micelle”) concentration showing cell viability of U-87 MG cell and HEK-293 cells treated with representative composite embodiments at different concentrations over 48 hours.", "FIGS.", "41A-41F are overlaid confocal images demonstrating the cellular uptake/internalization of RGD-conjugated, RAD-conjugated, and non-conjugated composites under the same dilution or concentration of composites (25 times dilution from the conjugate stock) by U-87 (FIGS.", "41A-41C) and HEK-293 (FIGS.", "41D-41F).", "FIG.", "42 is a graph of composite (or “micelle”) photoluminescence intensity as a function of composite (“micelle”) concentration showing the fluorescent intensity per unit area of cytoplasm for U-87 and HEK-293 cells incubated with non-conjugated micelles, RAD-conjugated micelles, and RGD-conjugated composites with different dilutions or concentrations (all p values for each comparison are less than 0.001).", "FIG.", "43 is an illustration of a sensing probe as described herein.", "FIGS.", "44A and 44B are spectra showing absorbance and photoluminescence intensity for composites comprising chloride shells (FIG.", "44A) and control examples without chloride shells (FIG.", "44B).", "FIGS.", "45A-45C illustrate results obtained from analyzing Mn-doped nanocrystals as described herein, wherein the surface doping is used; FIG.", "45A shows a representative synthesis of Mn:AIZS-ZnS nanocrystal embodiments and the effect of Mn levels on photoluminescence tunability, wherein AIZS cores are formed first, Mn and Zn precursors are added to the surface, and the nanocrystal surfaces are further passivated by zinc (yellow, red, and green represent AIZS composites, Mn, and ZnS shell, respectively); FIG.", "45B is a graph showing photoluminescence spectra of Mn:AIZS/ZnS nanocrystals as compared to an undoped AIZS/ZnS nanocrystal; and FIG.", "45C is a graph showing absorption spectra of the nanocrystals, wherein some there is some spectrum overlap between photoluminescence spectra and absorption spectra indicating some photoluminescence emissions will be reabsorbed by the nanocrystals themselves.", "FIG.", "46 illustrates XRD patterns of an undoped AIS/ZnS nanocrystal, a 0.025 mmol-Mn-doped AIS/ZnS nanocrystal, a 0.075 mmol-Mn-doped AIS/ZnS nanocrystal, and a 0.125 mmol-Mn-doped AIS/ZnS nanocrystal, wherein diffraction peaks of tetragonal AgInS2 and ZnS, as obtained from the JCPDS database (specifically, JCPDS #25-1330 and JCPDS #05-0566), are shown as references.", "FIGS.", "47A-47D illustrate images of a Mn-doped nanocrystal embodiments, wherein FIG.", "47A is a TEM image of a 0.075 mmol-Mn-doped AIZS/ZnS nanocrystal; FIG.", "47B is a high resolution TEM image of a 0.075 mmol-Mn-doped AIZS/ZnS nanocrystal; FIG.", "47C is a fast Fourier transform (FFT) pattern on the HRTEM image of a 0.075 mmol-Mn-doped AIZS/ZnS nanocrystal; and FIG.", "47D is an EDX spectrum of the 0.075 mmol-Mn-doped AIZS/ZnS nanocrystal, which illustrates Ag, In, Mn, Zn and S elements (and wherein the unlabeled peaks above 10 KeV are gold elements from the gold-mesh grid used for TEM imaging).", "FIG.", "48 is a graph illustrating photoluminescence decay curves of a 0.075 mmol-Mn-doped AIZS/ZnS nanocrystal, wherein the sample is excited at 300 nm by a xenon lamp and its photoluminescence decays were measured at different wavelengths.", "FIG.", "49 is a collection of photographic images illustrating results obtained from a thermal stability study of Mn:AIZS/ZnS nanocrystal, wherein the Mn:AIZS nanocrystal solutions are shown at room temperature, after heating at 170° C., and cooled down to room temperature under a UV lamp.", "FIGS.", "50A-50C are images illustrating results from analyzing a Mn-doped nanocrystal embodiment wherein the core of the nanocrystal is doped; FIG.", "50A is an illustration of such a nanocrystal wherein Mn atoms are doped into the core of an AZIS nanocrystal and then the cores are shelled with ZnS layers; FIG.", "50B is a graph showing fluorescence and absorption spectra of Mn-doped AZIS/ZnS nanocrystals; and FIG.", "50C is a graph showing fluorescence decays of Mn-doped AZIS/ZnS nanocrystals under different Ag levels in the composites.", "FIGS.", "51A and 51B provide a schematic illustration of a representative composite wherein a zwitterionic polymer encapsulates both magnetic nanoparticles and I(II)-III-VI quantum dots through self-assembly (FIG.", "51B) and representative magnetic resonance image and optical image of the composite at difference concentrations, wherein the concentration is marked by the Fe+Mn mass/mL (FIG.", "51B).", "FIG.", "52 is a graph illustrating results obtained from cell viability testing, wherein unconjugated and chlorotoxin-conjugated conjugates prepared using composite embodiments described herein were incubated with cells over 72 hours.", "FIGS.", "53A and 53B are images showing intracellular distribution of conjugated micelles in U-87, wherein micelles, endosomes or lysosomes are stained with Lysotracker green, and nuclei are stained with DAPI appear red, green, and blue, respectively; FIG.", "53A shows distribution after 3 hours of incubation; and FIG.", "53B shows distribution after 24 hours of incubation.", "FIGS.", "54A-54C shows results obtained from measuring the fluorescence lifetime of a control (organic dye C153) and two composite embodiments described herein, namely an Mn-doped AZIS/ZnS composite having an average lifetime of 0.1 ms (FIG.", "54B) and another embodiment having an average lifetime of 1 ms (FIG.", "54C), wherein the insets show the zero backgrounds.", "DETAILED DESCRIPTION I.", "Explanation of Terms The following explanations of terms are provided to better describe the present disclosure and to guide those of ordinary skill in the art in the practice of the present disclosure.", "As used herein, “comprising” means “including” and the singular forms “a” or “an” or “the” include plural references unless the context clearly dictates otherwise.", "The term “or” refers to a single element of stated alternative elements or a combination of two or more elements, unless the context clearly indicates otherwise.", "Unless explained otherwise, all technical and scientific terms used herein have the same meaning as commonly understood to one of ordinary skill in the art to which this disclosure belongs.", "Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present disclosure, suitable methods and materials are described below.", "The materials, methods, and examples are illustrative only and not intended to be limiting, unless otherwise indicated.", "Other features of the disclosure are apparent from the following detailed description and the claims.", "Unless otherwise indicated, all numbers expressing quantities of components, molecular weights, percentages, temperatures, times, and so forth, as used in the specification or claims are to be understood as being modified by the term “about.” Accordingly, unless otherwise indicated, implicitly or explicitly, the numerical parameters set forth are approximations that can depend on the desired properties sought and/or limits of detection under standard test conditions/methods.", "When directly and explicitly distinguishing embodiments from discussed prior art, the embodiment numbers are not approximates unless the word “about” is recited.", "Furthermore, not all alternatives recited herein are equivalents.", "To facilitate review of the various embodiments of the disclosure, the following explanations of specific terms are provided.", "Certain functional group terms include an Ra group that, though not part of the defined functional group, indicates how the functional group attaches to the compound to which it is bound.", "Aliphatic: A hydrocarbon, or a radical thereof, having at least one carbon atom to 50 carbon atoms, such as one to 25 carbon atoms, or one to ten carbon atoms, and which includes alkanes (or alkyl), alkenes (or alkenyl), alkynes (or alkynyl), including cyclic versions thereof, and further including straight- and branched-chain arrangements, and all stereo and position isomers as well.", "Alkyl: A saturated monovalent hydrocarbon having at least one carbon atom to 50 carbon atoms, such as one to 25 carbon atoms, or one to ten carbon atoms, wherein the saturated monovalent hydrocarbon can be derived from removing one hydrogen atom from one carbon atom of a parent compound (e.g., alkane).", "An alkyl group can be branched, straight-chain, or cyclic (e.g., cycloalkyl).", "Alkenyl: An unsaturated monovalent hydrocarbon having at least two carbon atoms to 50 carbon atoms, such as two to 25 carbon atoms, or two to ten carbon atoms, and at least one carbon-carbon double bond, wherein the unsaturated monovalent hydrocarbon can be derived from removing one hydrogen atom from one carbon atom of a parent alkene.", "An alkenyl group can be branched, straight-chain, cyclic (e.g., cycloalkenyl), cis, or trans (e.g., E or Z).", "Alkynyl: An unsaturated monovalent hydrocarbon having at least two carbon atoms to 50 carbon atoms, such as two to 25 carbon atoms, or two to ten carbon atoms and at least one carbon-carbon triple bond, wherein the unsaturated monovalent hydrocarbon can be derived from removing one hydrogen atom from one carbon atom of a parent alkyne.", "An alkynyl group can be branched, straight-chain, or cyclic (e.g., cycloalkynyl).", "Aryl: An aromatic carbocyclic group comprising at least five carbon atoms to 15 carbon atoms, such as five to ten carbon atoms, having a single ring or multiple condensed rings, which condensed rings can or may not be aromatic provided that the point of attachment is through an atom of the aromatic carbocyclic group.", "Carboxylate: RaC(O)O−, wherein Ra is the atom of the formulas disclosed herein to which the carboxyl group is attached.", "Composite: A material comprising a core (which may comprise a nanoparticle, a quantum dot having a core or core/shell structure, or a combination or plurality thereof) and a zwitterionic polymeric coating comprising a zwitterionic polymer having a structure satisfying a formula disclosed herein, wherein the zwitterionic polymer coating encapsulates the core and wherein the composite exhibits properties that differ from each of its individual components.", "Encapsulated: When a drug is described herein as “encapsulated,” it is intended to mean that the drug is located within or attached to polymer side chains of the zwitterionic polymeric coatings described herein and/or within the core of the composite as defined by the zwitterionic polymeric coating.", "Heteroaliphatic: An aliphatic group comprising at least one heteroatom to 20 heteroatoms, such as one to 15 heteroatoms, or one to 5 heteroatoms, which can be selected from, but not limited to oxygen, nitrogen, sulfur, selenium, phosphorous, and oxidized forms thereof within the group.", "Heteroalkyl/Heteroalkenyl/Heteroalkynyl: An alkyl, alkenyl, or alkynyl group (which can be branched, straight-chain, or cyclic) comprising at least one heteroatom to 20 heteroatoms, such as one to 15 heteroatoms, or one to 5 heteroatoms, which can be selected from, but not limited to oxygen, nitrogen, sulfur, selenium, phosphorous, and oxidized forms thereof within the group.", "Heteroaryl: An aryl group comprising at least one heteroatom to six heteroatoms, such as one to four heteroatoms, which can be selected from, but not limited to oxygen, nitrogen, sulfur, selenium, phosphorous, and oxidized forms thereof within the ring.", "Such heteroaryl groups can have a single ring or multiple condensed rings, wherein the condensed rings may or may not be aromatic and/or contain a heteroatom, provided that the point of attachment is through an atom of the aromatic heteroaryl group.", "Magnetic Nanoparticle: A class of nanoparticles that can be manipulated using magnetic field gradients.", "Quantum Dot: A nanoscale particle that exhibits size-dependent electronic and optical properties due to quantum confinement.", "The quantum dots disclosed herein generally have at least one dimension less than 100 nanometers.", "The disclosed quantum dots may be colloidal quantum dots, i.e., quantum dots that may remain in suspension when dispersed in a liquid medium.", "Sulfonate: A functional group having a formula RaSO3−, wherein Ra is the atom of the formulas disclosed herein to which the sulfonate is attached.", "Zwitterionic Polymer/Zwitterionic Polymeric Coating: A polymer or polymeric coating disclosed herein that comprises both positive and negative electrical charges and that comprises a polymeric backbone having one or more zwitterionic side-chains extending therefrom.", "Typically, the polymers and polymeric coatings comprise at least one functional group that comprises a positive charge and at least one functional group that comprises a negative charge, and in most embodiments both such functional groups are located in the same polymer side chain (as distinguished from the polymer backbone).", "II.", "Introduction Micellar magnetofluorescent nanoparticles inherit the merits of magnetic nanoparticles (e.g., high saturation magnetization) and quantum dots (e.g., photostability and luminescence wavelength tunability), and also provide complementary merits from both magnetic resonance imaging and optical imaging (i.e., high spatial resolution and high sensitivity).", "Conventional methods used to produce magnetofluorescent nanoparticles require forming a hydrophilic shell using anti-fouling poly(ethylene glycol) (PEG) chains to achieve colloidal stability and biocompatibility for various in vitro or in vivo applications.", "Although PEG chains render such nanoparticles stable in physiological media, PEG groups are sensitive to solution pH and salinity and tend to cause such nanoparticles to aggregate in acidic or salt-rich microenvironments.", "This aggregation further degrades and can even change the diagnosis/therapy functionalities devised for original nanoparticles.", "This shortcoming of PEG-functionalized magnetofluorescent nanoparticles limits their applications in biological or biomedical applications, where harsh conditions are ubiquitous.", "For instance, many cellular organelles are maintained under acidic conditions and rich in salts.", "Moreover, it has been suggested in the art that PEG may induce in vivo production of anti-PEG immunoglobulin M (IgM) antibodies, which further affects in vivo applications of PEG coated magnetofluorescent nanoparticles.", "Other conventional magnetofluorescent nanoparticles comprise cadmium-based quantum dots and/or gold nanoparticles with dihydrolipoic acid that can undergo ligand exchange with trioctylphosphine oxide ligands to form zwitterionic cadmium-based quantum dots or gold nanoparticles with singular ligands that are coupled to the cadmium core through a sulfur atom.", "Zwitterion coupled thiol ligands, however, have not been applicable to the preparation of magnetofluorescent nanoparticles integrating both magnetic nanoparticles and quantum dots.", "These thiol ligands are individually attached to the core and do not comprise a polymeric backbone.", "The disclosed composites and methods of making the same address deficiencies associated with conventional composites and techniques.", "For example, scalable syntheses of high quality quantum dots are desired because a large amount of bright quantum dots can be produced in a single synthetic reaction to sustain biomedical research for reliable experimental observation or data collection and also save synthesis costs.", "The disclosed methods provide the ability to obtain such scalable syntheses.", "In addition, since quantum dots usually are synthesized in organic solvents and thus capped with hydrophobic ligands, facile surface/interface chemistries are required to render I—III-VI quantum dots water-dispersible and also to provide functional groups for subsequent bio-conjugation with biological moieties.", "The disclosed composites and compositions address this need.", "Additionally, the composites disclosed herein possess several merits including dual imaging properties, high (Mn+Fe) recovery, excellent stability in aqueous solutions with a wide pH/ionic-strength range and physiological media, minimal cytotoxicity, the ability to tune photoluminescence by surface doping, and cell targeting capabilities before and after bio-conjugation.", "Without being limited to a particular theory, it is currently believed that the high recovery of the composites is attributed to the efficient wrapping of the composite cores by the aliphatic tails of the zwitterionic polymeric coating, and that the colloidal stability, and minimal cytotoxicity for cell targeting results from the nature of the incorporated zwitterionic groups.", "Additionally, the composites can be used for cell imaging and the photoluminescence tunability of the composites from the visible to near infrared (NIR) range contributes to their utility in in vivo diagnosis.", "The fluorescence imaging data obtained from the composites (e.g., NIR and magnetic resonance imaging) may also be used to provide complimentary information on tumor biology and thus enhance diagnosis accuracy.", "III.", "Composites and Compositions Disclosed herein are embodiments of composites and compositions thereof, wherein the composites comprise a core having a nanoparticle, quantum dot, or combination thereof and a polymeric coating that encapsulates the core.", "In exemplary embodiments, the composites comprise magnetofluorescent cores and a zwitterionic polymeric coating suitable for promoting biocompatibility and coupling to biomolecules.", "In particular disclosed embodiments, the magnetofluorescent core comprises at least one quantum dot and at least one magnetic nanoparticle.", "The zwitterionic polymer coating, which comprises a polymeric backbone from which zwitterionic side chains extend, can be used to encapsulate the core of the composite, such as by forming a polymeric layer that surrounds a composition of magnetic nanoparticles, quantum dots, or a combination thereof.", "In particular disclosed embodiments, the zwitterionic polymeric coating comprises a polymer having a hydrophobic portion and a hydrophilic portion.", "The hydrophobic portion can be oriented so that it interacts with the core comprising the magnetic nanoparticles, quantum dots, or combination thereof to form a micellar core.", "The hydrophilic portion can be oriented so that it extends from the micellar core to promote solubility and/or biomolecular conjugation.", "In some embodiments, the zwitterionic polymeric coating can comprise a polymer having a pH-responsive group, which can comprise a combination of a functional group positioned on the polymeric chain of the polymer, which comprises a tertiary amine, and a functional group positioned on the polymeric chain of the polymer, which comprises a carboxyl group.", "The combination of these two functional groups can provide a weak zwitterionic moiety.", "In such a weak zwitterion, the free proton from the carboxyl group can be transferred to the tertiary amine without affecting the neutral charge of the whole pair.", "In some embodiments, the pKa of the carboxyl group of the weak zwitterionic moiety is around 5.0-6.0, and can be protonated in acidic endosomes and thus lead to osmotic swelling and endosome rupture benefitting the ensodomal escape of micelles.", "In yet additional embodiments, the zwitterionic polymer can comprise carboxybetaine groups that can also absorb protons in acidic conditions for endosomal escape.", "In some embodiments, the molar ratio of functional groups present on the zwitterionic polymeric coating (e.g., carboxybetaine groups, sulfobetaine groups, pH responsive groups, and thiol-containing groups) can be modified to provide a desired reactivity of the micelle formed with the polymeric coating and the core.", "In particular disclosed embodiments, the zwitterionic polymeric coating can comprise a polymer having a structure meeting Formula I below.", "With reference to Formula I, each R1 can provide the hydrophobic portion of the polymer and independently can be selected from hydrogen or aliphatic; each R2 independently can be —C(O)Z, wherein Z can be selected from hydroxyl, ether, amine, thiol, or thioether; each R3 can (alone or in combination with R2) provide the hydrophilic portion of the polymer and independently can be selected from amide-aliphatic-amine (e.g., —CO(NRb)C1-C10alkylN(Rb)2, wherein each Rb independently can be selected from hydrogen, aliphatic, heteroaliphatic, aryl, or heteroaryl), amide-aliphatic-amine-aliphatic-carboxylate (e.g., —CO(NRb)C1-C10alkyl [N(Rb)2]+C1-C10alkyl-CO2−, wherein each Rb independently can be selected from hydrogen, aliphatic, heteroaliphatic, aryl, or heteroaryl), amide-aliphatic-amine-aliphatic-sulfonate (e.g., —CO(NRb)C1-C10alkyl [N(Rb)2]+C1-C10alkyl-SO3−, wherein each Rb independently can be selected from hydrogen, aliphatic, heteroaliphatic, aryl, or heteroaryl), or amide-aliphatic-thiol (e.g., —CO(NRb)C1-C10alkylSH, wherein Rb can be selected from hydrogen, aliphatic, heteroaliphatic, aryl, or heteroaryl); p can be an integer selected from zero to 5; q can be an integer selected from zero or 1; and each of a and b independently can be an integer selected from 1 to 200.In some embodiments, the zwitterionic polymeric coating can comprise a polymer having a structure satisfying any one of Formulas II-VI below.", "With reference to Formulas II-VI, each R1 independently can be selected from hydrogen or aliphatic; each X1, X2, X3, X4, and X5 independently can be selected from NRb, N(Rb)2+, oxygen, or sulfur, wherein each Rb independently can be selected from hydrogen, aliphatic, heteroaliphatic, aryl, or heteroaryl; each A1, A2, A3, A4, and A5 independently can be selected from aliphatic or heteroaliphatic; each Y1, Y2, and Y3 independently can be selected from amine, thiol, carboxylate or sulfonate; each Z independently can be selected from hydroxyl, ether, amine, thiol, or thioether; n can be an integer selected from 1 to 200; each m can be an integer selected from 0 to 3, such as 0, 1, 2, or 3; each p independently can be an integer selected from zero to 5; a can be an integer selected from 1 to 200, such as 1 to 100 or 5 to 50; and b and c independently can be an integer selected from 0 to 200, such as 1 to 100 or 5 to 50.In particular disclosed embodiments, each R1 independently can be selected from hydrogen, alkyl, alkenyl, or alkynyl; each X1, X2, X3, X4, and X5 independently can be selected from NRb, N(Rb)2+, oxygen, or sulfur, wherein each Rb independently can be selected from hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, phenyl, naphthyl, or pyridinyl; each A1, A2, A3, A4, and A5 independently can be selected from alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, or heteroalkynyl; each Y1 and Y2 independently can be selected from carboxylate or sulfonate; Y3 can be SH; each Z independently can be selected from hydroxyl, thiol, or NH2; and m is 1.In yet additional embodiments, each R1 independently can be selected from hydrogen or C1-C20 alkyl (such as C1-C16 alkyl, or C1-C10 alkyl); each X1, X2, X3, X4, and X5 independently can be selected from NH or NMe2+; each A1, A2, A3, A4, and A5 independently can be selected from C1-C20 alkyl (such as C1-C10 alkyl or C1-C5 alkyl, or C1-C3 alkyl); each Y1 and Y2 independently can be selected from carboxylate or sulfonate; Y3 can be SH; and each Z independently can be hydroxyl.", "In exemplary embodiments, the zwitterionic polymer coating can have any one of the structures below.", "The composites disclosed herein can comprise a core that includes a nanoparticle, a quantum dot, or a combination thereof.", "In particular embodiments, the core comprises a magnetic nanoparticle, a quantum dot, or a combination thereof.", "In yet additional embodiments, the core comprises a magnetic nanoparticle and a quantum dot.", "In such embodiments, the core is considered magnetofluorescent.", "In particular disclosed embodiments, the composite comprises MnFe2O4 magnetic nanoparticles, CuInS2 quantum dots, AgInS2 quantum dots, or any combination thereof.", "In some embodiments, the nanoparticles are magnetic and can be nanoparticles comprising a metal selected from Mn, Fe, Ni, Co, or combinations thereof.", "In particular disclosed embodiments, the magnetic nanoparticle comprises a metal and/or a metal oxide, such as an iron oxide, a nickel oxide, a cobalt oxide, a manganese oxide, or a combination thereof.", "Exemplary magnetic nanoparticles include, but are not limited to MnFe2O4, Fe3O4, CoFe2O4, FePt, or a combination thereof.", "In some embodiments, the nanoparticles, quantum dots, or both can have core sizes of greater than 1 nm to 10 nm, such as 1 nm to 8 nm, or 1 nm to 5 nm.", "Suitable quantum dots that can be used in the composites disclosed herein include, but are not limited to, tertiary or ternary quantum dots, such as AgInS2, Ag(In,Ga)Se2, Ag(Zn,Sn)Se2, Ag(Zn,Sn)S2, AgIn(Se,S)2, AgZn(Se,S)2, AgSn(Se,S)2, and Ag(Zn,Sn)(Se,S)2ZnSSe, ZnSeTe, ZnSTe, ScSTe, HgSSe, HgSeTe, HgSTe, ZnHgS, ZnHgSe, ZnHgTe, ZnHgSSe, ZnHgSeTe, InGaAs, GaAlAs, InGaN, CuInS2, Cu(In,Ga)Se2, Cu(Zn,Sn)Se2, Cu(Zn,Sn)S2, CuIn(Se,S)2, CuZn(Se,S)2, CuSn(Se,S)2, and Cu(Zn,Sn)(Se,S)2.In some embodiments, the quantum dots used in the composites are quantum dots.", "Exemplary quantum dots include, but are not limited to, CuInS2 quantum dots and AgInS2 quantum dots.", "The quantum dot can be a core quantum dot or a core/shell quantum dot.", "In core/shell embodiments, the quantum dot can be selected from any quantum dot described herein and can further comprise a shell made of a binary material selected from, but not limited to, CdS, CdSe, CdTe, GaAs, InAs, InN, InP, InSb, PbS, PbSe, PbTe, ZnS, ZnSe, or ZnTe; an ion species, such as a halide (e.g., bromide, chloride, fluoride, or iodide); or a combination thereof.", "In exemplary embodiments, ZnS or chloride is selected as the shell component.", "Exemplary embodiments of core/shell quantum dots include, but are not limited to, CuInS2/ZnS quantum dots and AgInS2/ZnS quantum dots.", "Core and core/shell quantum dots can be used in combination with nanoparticles, particularly nanoparticles, to form an overall core used in the composites disclosed herein.", "The core of the composite also can be doped with one or more metals.", "In particular disclosed embodiments, quantum dots (core and/or core/shell quantum dots) and/or nanoparticles (e.g., magnetic nanoparticles) can be doped with a metal selected from Cu, Ag, Au, Mn, Zn, or combinations thereof.", "Doping the cores of the disclosed composites provides the ability to tune the optical properties and material characteristics of the cores and also can prolong the photoluminescence lifetime of the composites disclosed herein.", "Photoluminescence tuning of the composites can be used avoid cross-talk with other existing dyes in bioimaging/sensing, and also provides design flexibility for optoelectronic devices, such as light-emitting diodes (LEDs) with different color emissions.", "Like other composites disclosed herein, the doped cores can be encapsulated with the zwitterionic polymeric coatings disclosed herein to form composites.", "The doped composites can be used as photoluminescent probes in cellular imaging and tissue imaging.", "Also disclosed herein are compositions comprising the composites described above and one or more biomolecules.", "In some embodiments, the biomolecules of the composition can be the same.", "In yet other embodiments, multiple different biomolecules can be used.", "Biomolecules can be selected from targeting ligands, antibodies, nucleic acids, therapeutic molecules, or a peptide having biofunctionality, or combinations thereof.", "In exemplary embodiments, the biomolecules can be selected from chlorotoxin, avidin, biotin, folic acid, arginylglycylaspartic acid, or combinations thereof.", "The biomolecules can be chemically conjugated to the composites, such as electrostatically and/or covalently.", "In some embodiments, biomolecules can be covalently bound to functional groups on the composite, such as carboxylate groups of the zwitterionic polymer coating.", "In some embodiments, the composites can comprise a mixture of carboxylate and sulfonate functional groups to facilitate conjugation to biomolecules through the carboxylate groups and also to maintain the zwitterionic nature of the polymer using sulfonate groups, which do not react with the biomolecules.", "In some embodiments, the disclosed compositions can be used to determine and demonstrate the biomedical uses of the composites and compositions, such as by performing cellular/tissue studies to investigate cytotoxicity of the composites and/or compositions and specific cellular binding/uptake of conjugated composites by cells, such as tumor cells.", "In some embodiments, drugs, such as chemotherapy drugs (e.g., doxorubicin, daunorubicin, epirubicin, idarubicin, or the like) can be loaded into the cores of micelles for therapeutic drug delivery applications.", "Once exposed to physiological conditions (e.g., circulation environments), drugs encapsulated in micelles usually are released within the first several hours, after which their concentrations reach a saturation plateau.", "The burst release should be minimal before micelles are internalized into target cells, but efficient after they are in target cells.", "To prevent premature drug leakage, thiol groups can be incorporated into the zwitterionic polymer to form disulfide cross-linkages in oxidative conditions and thereby form a cross-linked layer of the zwitterionic polymeric coating.", "FIG.", "33 illustrates an exemplary embodiment wherein a cross-linked layer 3300 is formed by thiol groups of a polymeric coating backbone.", "The presence to thiol groups can help different polymer backbones to cross link with each other and form a shell on the surface.", "This shell is stable under physiological conditions minimizing drug leakage, but sensitive to and degradable in intracellular reductive-microenvironments.", "As illustrated in FIG.", "33, the cross-linked layer can encapsulate quantum dots 3302 and drug molecules 3304.The devised shell is designed to help micelles to achieve more drug release inside cells.", "The composites disclosed herein can be characterized using a variety of techniques.", "In some embodiments, Fourier transform infrared (FT-IR) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy can be used to characterize the composites.", "In yet additional embodiments, the composites can be characterized based on their particle composition and size, iron content recovery rates, optical properties, colloidal stability, and magnetic relaxivity in harsh conditions using transmission electron microscopy (TEM), energy-dispersive X-ray (EDX) spectroscopy, dynamic light scattering (DLS), UV-Vis spectroscopy, fluorescence spectroscopy, magnetic resonance spectroscopy, and combinations thereof.", "IV.", "Methods of Making Composite Components, Composites, and Compositions Described herein are embodiments of methods for making the composite components described above, the composites themselves, and compositions comprising the composites.", "Methods for making composite components, such as the zwitterionic polymer coating and the quantum dots that can be used in the magnetofluorescent core also are described below.", "In some embodiments of making the zwitterionic polymers described herein, the methods comprise converting a polymer precursor to a polymeric intermediate, which can then be reacted with suitable reagents that provide the zwitterionic portion of the polymer.", "As illustrated in Scheme 1, polymeric precursor 100 can be converted to polymeric intermediate 102 by addition of an appropriate nucleophile to polymeric precursor 100, which ring-opens to provide polymeric intermediate 102.With respect to Scheme 1, each R1, R2, X2, A1, m a, and p can be as recited above; Za can be selected from oxygen or NRb; and each R4 independently can be selected from hydrogen or aliphatic.", "In particular embodiments, a method as illustrated in Scheme 2 can be used to produce polymeric intermediate 202 from polymeric precursor 200.In some embodiments, the zwitterionic polymer coating can comprise functional groups suitable for forming disulfide cross-linkages within the polymeric coating to thereby form a cross-linked layer of the polymer (FIG.", "33).", "In such embodiments, the disulfide-containing polymers can be made by reacting a polymeric precursor with a disulfide-containing reagent, such as 2-(2-pyridyldithio)ethylamine.", "The disulfide bond of the disulfide-containing reagent can be reduced to a thiol using excess dithiothreitol (DTT).", "The crosslinking between thiol groups of the polymeric coating can be conducted under aqueous oxidative conditions during the removal of DTT from micelles by dialysis against PBS buffer.", "The polymeric intermediate can then be converted to a zwitterionic polymer 300 by reacting polymeric intermediate 102 with one or more different electrophiles capable of providing a carboxylate moiety, a sulfonate moiety, or a combination thereof, as illustrated in Scheme 3 below.", "In some embodiments, a cyclic lactone and/or a cyclic sulfone can be used as the electrophile component.", "An exemplary method of producing a zwitterionic polymer is illustrated below in Scheme 4.As illustrated in Scheme 4, polymeric intermediate 202 is reacted with β-propiolactone and 1,3-propanesultone in one step to provide the carboxylate- and sulfonate-containing zwitterionic polymer 400.This method can be used to produce such compounds in one step without having to utilize multiple steps to attach both the carboxylate and the sulfonate moieties.", "The resulting zwitterionic polymer possesses carboxybetaine groups, sulfobetaine groups, and hydrophobic groups on their backbones.", "Compared to sulfobetaine, carboxybetaine groups are not only zwitterions but also supply carboxyl heads for bio-conjugation with conventional EDC/NHS cross-linkers.", "The sulfobetaine groups are insensitive to regular bio-crosslinking reactions and thus keep the zwitterionic property of the amphiphiles during conjugation.", "Although simple carboxyl groups are presented on the polymer backbone, carboxybetaine in the polymeric coating can further increase the biomolecule loading capability of composites through bio-crosslinking.", "Moreover, carboxybetaine branches can be provided that are similar to or substantially similar to the length of the sulfobetaine branches and therefore are easy to access for bio-conjugation.", "In yet additional embodiments, the zwitterionic polymeric coating can be made by first making a functionalized zwitterionic intermediate 500 and then reacting the functionalized zwitterionic intermediate 500 with a polymeric precursor 100, such as is illustrated in Scheme 5.With respect to Scheme 5, each of R1, R2, R4, X1, X2, A1, Za, m, a, and p can be as recited above.", "A representative method of making the zwitterionic polymer in this fashion is illustrated in Scheme 6 below.", "To produce the composites, the zwitterionic polymeric coating together with hydrophobic magnetic nanoparticles, quantum dots, or a combination thereof can be dissolved in organic solvents and then dispersed into water under sonication.", "FIG.", "32 provides an exemplary schematic of a representative method of making micelles comprising the polymeric coatings disclosed herein.", "As illustrated in FIG.", "32, an organic solution 3200 comprising a polymer as disclosed herein, one or more quantum dots, nanoparticles, a drug, or any combination thereof is mixed with water and undergoes sonication using a sonicator 3202.After sonication the micelles begin to form (3204) and vacuum removal of the organic solvents provides the formed micelles (3206).", "After dispersion, organic solvents can be removed by vacuum under rotary evaporation.", "In the dispersion and vacuum, hydrophobic alkyl tails in the amphiphiles interact with hydrophobic nanoparticles, quantum dots, or both to form the stable micellar cores, and carboxylate and sulfonate groups are exposed to water.", "In some embodiments, the quantum dots used in the composites disclosed herein can be made using a thermal decomposition method.", "The thermal decomposition method can be easily scaled up to a commercial scale for quantum dot production as compared to conventional hot-injection methods.", "In some embodiments, a quantum dot precursor is used in the thermal decomposition method.", "In comparison to hot-injection methods, the present method does not require multiple washing and dryings steps or the use of toxic sodium diethyldithiocarbamate to produce the quantum dot precursor.", "Instead, the present methods use metal precursors and non-toxic ligands to produce the quantum dots in situ.", "No complex precursors, external sulfur sources, or other solvents are needed.", "Also, all chemicals used in the methods are commercially available.", "The thermal decomposition methods described herein can comprise combining a Group 11 metal precursor, a Group 13 metal precursor, and a ligand in a thiol-containing solvent.", "In some embodiments, the Group 11 metal precursor is selected from a silver precursor or a copper precursor.", "In some embodiments, the Group 13 metal precursor is an indium precursor.", "In particular disclosed embodiments, silver acetate or copper acetate can be used as the Group 11 metal precursor and indium acetate can be used as the Group 13 metal precursor.", "Suitable ligands include, but are not limited to fatty acids, such as oleic acid, palmitoleic acid, linoleic acid, and the like.", "In some embodiments, the thiol-containing solvent is dodecanethiol, octadecanethiol, octanethiol, decanethiol, or combinations thereof.", "The Group 11 metal precursor, the Group 13 metal precursor, and the ligand are combined in the thiol-containing solvent and are heated at a temperature suitable to facilitate thermal decomposition of the precursors to thereby form the desired quantum dots, such as quantum dots.", "In some embodiments, the temperature ranges from 150° C. to 200° C., such as 160° C. to 190° C., or 170° C. to 180° C. In particular disclosed embodiments, the reaction mixture of the Group 11 metal precursor, the Group 13 metal precursor, the ligand, and the solvent is heated at 170° C. In some embodiments, the methods can use a particular ratio of metal precursors to provide the disclosed quantum dots.", "In some embodiments, a Group 11:Group 13 metal precursor molar ratio ranging from 1:1 to 1:5 can be used, such as 1:1 to 1:4, or 1:1 to 1:3, or 1:1 to 1:2.In exemplary embodiments, an Ag:In molar ratio of 1:2 or a Cu:In molar ratio of 1:2 can be used.", "In some embodiments, the method can further comprise growing a shell on the quantum dot surface to enhance quantum yield.", "To enhance the quantum dot quantum yield (QY), a ZnS shell can grown on the quantum dot surface to form quantum dots having increased quantum yield as compared to quantum dots without a shell.", "In an exemplary embodiment of the thermal decomposition methods disclosed herein, which is described solely by way of example, indium acetate and silver acetate or copper acetate can be reacted with a sulfur source, such as dodecanethiol, to form intermediate compounds of Ag(SC12H25)x or Cu(SC12H25)x and In(SC12H25)x upon heating and are dissolved in dodecanethiol.", "As the reaction temperature is raised to a temperature ranging from 150° C. to 200° C.", "(e.g., 160° C. to 190° C., or 170° C. to 180° C.) the intermediate compounds can act as precursors and further decompose to form Ag—S or Cu—S and In—S to form Ag—In—S or Cu—In—S particles.", "Without being limited to a particular theory, it is currently believed that a 1:2 molar ratio of Cu:In or Ag:In can be used to circumvent the possibility of producing Ag2S or Cu2S particles.", "To further enhance the quantum yield, the AIS or CIS quantum dots can be passivated with a shell, such as a ZnS shell to form AIS/ZnS or CIS/ZnS quantum dots.", "In some embodiments, the core/shell quantum dots exhibited a significant quantum yield up to 41% but with a blue shift, as demonstrated in FIG.", "1.Embodiments of doped composites can be made using new synthetic methods disclosed herein that are reproducible and avoid multiple washing/drying steps and complex synthetic reactions.", "In particular disclosed embodiments, the methods use dopant precursors that are commercially available and relatively safe to use (e.g., no glove box is needed in preparing these precursors, and no highly restricted handling or disposal is required).", "In some embodiments, the methods described above for making the composites can be further modified to include a step whereby dopant precursors, such as CuI, Mn(acetate)2, Zn(acetate)2, AgNO3, Au(acetate)3, and the like, are added to composite solutions to provide surface-doped composites.", "In yet additional embodiments, doped composites comprising a core passivated with a shell can be made by coating and/or etching the shell components onto a doped core composition formed using a dopant precursor and a composite solution.", "Thus, in particular disclosed embodiments, a surface doping method is used, in contrast to a homogenous doping technique where the dopant is merely added to the precursors used to make the composite.", "The amount of dopant added can range from greater than 0 mol % to 15 mol %, such as from greater than 0 mol % to 10 mol %, or 3 mol % to 10 mol %, or 6 mol % to 10 mol %.", "In some representative embodiments, 3.33 mol %, 6.67 mol % and 10 mol % of the dopant can be added.", "In particular disclosed embodiments, a dopant precursor can be dissolved in a suitable solvent and then added dropwise to a solution comprising the un-doped composite.", "The composite solution can be heated to temperatures ranging from 120° C. to 200° C. or higher prior to addition of the dopant.", "After the dopant is added, the resulting reaction mixture can be cooled to ambient temperature.", "Methods for making doped core/shell composites can comprise preparing a doped composite as described above and then growing the shell on the doped core by adding selected shell precursors to a solution comprising the doped composite.", "In particular disclosed embodiments, the amount of the shell precursor added to the solution typically is an amount that would provide a sufficient number of shell atoms absorbed on to the surface of the doped composite; thus, in some embodiments, the amount can be determined based on the diameter of the doped composite.", "As an exemplary embodiment, doped core/shell composites can be obtained by preparing a shell precursor solution having a fixed concentration of the shell precursor, such as Zn(acetate)2, and then injecting a selected volume of the shell precursor solution (e.g., 0.5 mL) into a reactor comprising the doped composite.", "In some embodiments, at least 1 to 20 injections, such as 1 to 15 injections, or 2 to 10 injections, or 4 to 9 injections of the shell precursor solution can be added.", "After each injection, the quantum yield of the composites can be assessed to provide a curve of quantum yield as a function of injection time.", "This curve can be used to obtain suitable injection times and the total amount of the precursor solution to be added to provide the desired core/shell doped composites.", "The doping methods described above can be used to provide doped composites that exhibit high quantum yields (e.g., 50% or higher, such as 60% or higher) and prolonged photoluminescent lifetimes (e.g., 300 ns or more, such as 500 ns or more).", "The optical properties and material characteristics of the doped composites can be characterized using photoluminescence spectroscopy, UV-Vis spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), energy-dispersive X-ray (EDX) spectroscopy, time-resolved photoluminescence spectroscopy, or combinations thereof.", "V. Methods of Using Composites and Compositions The composites and compositions described herein can be used for biomedical imaging, biosensing, and therapeutic treatment.", "In some embodiments, the composites and compositions can be used for cell- or tissue-based diagnosis and therapy.", "For example, the composites and compositions can be used as contrast agents and/or probes for imaging cells, tumors, and/or detecting endogenous targets expressed in cells.", "In some embodiments, the compositions can comprise a composite and a biomolecule having therapeutic activity and/or a therapeutic drug and therefore the compositions can be used to treat, prevent, and/or ameliorate a disease or disorder.", "The disclosed composites and compositions are non-toxic, stable, and aqueous-soluble, and thus are suited for imaging of subjects both in vitro and in vivo as well as for drug delivery to a subject.", "In some embodiments, the composites and/or composite components (e.g., cores and/or zwitterionic polymer) can be used as imaging probes for flow cytometry, cell and tissue staining, cell tracking, Western blotting, in vivo imaging, and the like.", "In yet additional embodiments, the composites can be used as sensing probes.", "An exemplary sensing probe is illustrated in FIG.", "43.According to the embodiment illustrated in FIG.", "43, a sensing probe 4300 comprises an absorbent portion 4302, a capturing antibody portion 4304, a membrane (e.g., a nanocellulose membrane) 4306, a composite portion 4308, which comprising one or more of the composites disclosed herein, and a sample application portion 4310.Sensing probes like that illustrated in FIG.", "43 can be used to detect the presence of a particular analyte of interest.", "When such sensors are used, the photoluminescence produced by the composite portion can be used as a signal under continuous excitation.", "As the composites exhibit long photoluminescence lifetimes, the time-resolved photoluminescence of these composites also can be used as signals.", "In such embodiments, the time-resolved photoluminescence signals are produced by exciting the composites with a pulse light source; after the pulse excitation light is switched off, the composites will still emit fluorescence for several hundred nanoseconds or longer.", "Such a time-resolved signal can avoid the interference of any background (autofluorescence).", "In particular disclosed embodiments, the disclosed composites are combined with a biomolecule to produce a composition.", "The biomolecule can be coupled to the composite chemically, such as through a covalent or electrostatic bond.", "In some embodiments, the biomolecule can be covalently coupled to the composite using conjugation reagents and methods, such as by maleimide-thiol reaction chemistry, NHS-ester reaction chemistry, amino acid couplings, and the like.", "The coupling of the composite and the biomolecule can be evaluated and confirmed using FT-IR spectroscopy.", "After conjugation of the composite and the biomolecule to form the composition, it can be administered to a subject or it can be exposed to a sample in vitro.", "The composition can be administered using any suitable administration route, such as oral administration, injection, topical administration, inhalation, or a combination thereof.", "In particular disclosed embodiments, the composition can further comprise a pharmaceutically acceptable carrier, such as water or other pharmaceutically acceptable solvent.", "In some embodiments, the composition can be administered as a solution, a dispersion, a tablet, or a capsule.", "In some embodiments, the doped composites disclosed herein can be in various biomedical applications, such as cell targeting and imaging applications.", "In particular disclosed embodiments, the doped composites comprise a zwitterionic polymeric coating disclosed herein.", "These doped composites can be conjugated to targeting moieties, such as antibodies, haptens, peptides, a member of a specific binding pair, and other suitable targeting biomolecules.", "In particular disclosed embodiments, the doped composites can be coupled to peptides using peptide coupling reagents, such as, but are not limited to 2-(7-aza-1H-benzotriazol-1-yl)-N,N,N′,N′-tetramethylaminium hexafluorophosphate, 2-(1H-benzotriazol-1-yl)-N,N,N′,N′-hexafluorophosphate, 2-(6-chloro-1H-benzotriazol-1-yl)-N,N,N′,N′-tetramethylaminium hexafluorophosphate, 1-hydroxybenzotriazole, dicyclohexylcarbodiimide, diisopropylcarbodiimide, N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide-HCl, benzotriazol-1-yloxy-tris(dimethylamino)-phosphonium hexafluorophosphate, benzotriazol-1-yloxy-tripyrrolidino-phosphonium hexafluorophosphate, bromo-tripyrrolidino-phosphonium hexafluorophosphate, and the like, or a combination thereof.", "These peptide coupling reagents also can be used for other composites disclosed herein (that is, non-doped composites).", "In particular disclosed embodiments, the doped composites can be coupled to an RGD peptide for targeting tumors and/or mutations in brain cells, kidney cells, liver cells, breast tissue cells, and the like.", "In yet additional embodiments, the doped composites (and other composites disclosed herein) can be combined with therapeutics and/or image contrast agents to deliver drugs to particular targets within a subject and/or to provide additional imaging of such targets.", "VI.", "Overview of Several Embodiments Some embodiments disclosed herein concern composites comprising a core comprising one or more magnetic nanoparticles, one or more quantum dots, or a combination thereof; and a zwitterionic polymeric coating comprising a zwitterionic polymer having a structure satisfying a formula wherein each R1 independently is selected from hydrogen or aliphatic; each R2 is —C(O)Z, wherein Z is selected from hydroxyl, ether, amine, thiol, or thioether; each R3 independently is selected from amide-aliphatic-amine, amide-aliphatic-amine-aliphatic-carboxylate, amide-aliphatic-amine-aliphatic-sulfonate, or amide-aliphatic-thiol; p is an integer selected from zero to 5; q is an integer selected from zero or 1; and each of a and b independently is an integer selected from 1 to 200.In some embodiments, the zwitterionic polymeric coating comprises a zwitterionic polymer having a structure satisfying a formula selected from wherein each R1 independently is selected from hydrogen or aliphatic; each of X1, X2, X3, X4, and X5 independently is selected from NRb, N(Rb)2+, oxygen, or sulfur, wherein each Rb independently is selected from hydrogen, aliphatic, heteroaliphatic, aryl, or heteroaryl; each of A1, A2, A3, A4, and A5 independently is selected from aliphatic or heteroaliphatic; each of Y1, Y2, and Y3 independently is selected from amine, thiol, carboxylate or sulfonate; each Z independently is selected from hydroxyl, ether, amine, thiol, or thioether; n is an integer selected from 1 to 200; each m is an integer selected from 0 to 3; each p independently is an integer selected from zero to 5; each of a, b, and c independently is an integer selected from 1 to 200.In any or all of the above embodiments, each R1 independently is selected from hydrogen, alkyl, alkenyl, or alkynyl; each of X1, X2, X3, and X5 independently is selected from NRb, N(Rb)2+, oxygen, or sulfur, wherein each Rb independently is selected from hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, phenyl, naphthyl, or pyridinyl; each of A1, A2, A3, A4, and A5 independently is selected from alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, or heteroalkynyl; each of Y1 and Y2 independently is selected from carboxylate or sulfonate and Y3 is thiol; each Z is hydroxyl; and m is 1.In any or all of the above embodiments, the zwitterionic polymeric coating comprises a zwitterionic polymer have a structure In any or all of the above embodiments, the core comprises at least one magnetic nanoparticle and at least one quantum dot.", "In any or all of the above embodiments, the core is doped with a metal selected from Cu, Ag, Au, Mn, Zn, or combinations thereof.", "In some embodiments, the core is doped with greater than 0 mol % to 10 mol % of the metal.", "In any or all of the above embodiments, the core is a quantum dot core and the quantum dot core comprises a ZnS shell.", "In some embodiments, the quantum dot core exhibits a quantum yield of greater than 50%.", "In any or both of these embodiments, the quantum dot core exhibits a photoluminescence lifetime ranging from 300 to 500 nanoseconds.", "In any or all of the above embodiments, the quantum dot is a quantum dot.", "In any or all of the above embodiments, wherein the quantum dot comprises copper or silver.", "In any or all of the above embodiments, the quantum dot is an AgInS2 quantum dot or a CuInS2 quantum dot.", "In any or all of the above embodiments, the quantum dot further comprises a ZnS shell.", "In any or all of the above embodiments, the magnetic nanoparticle comprises Fe.", "In any or all of the above embodiments, wherein the magnetic nanoparticle is MnFe2O4, Fe3O4, CoFe2O4, FePt or a combination thereof.", "In any or all of the above embodiments, the core comprises a combination of MnFe2O4 nanoparticles and an AgInS2 quantum dot, a CuInS2 quantum dot, or a combination thereof.", "Also disclosed herein are embodiments of composites comprising: a core comprising a combination of MnFe2O4 nanoparticles and CuInS2 quantum dots, AgInS2 quantum dots, or both; and a zwitterionic polymeric coating comprising a zwitterionic polymer having a structure selected from In any or all of the above embodiments, the core further comprises a dopant, a shell, or both.", "In some embodiments, the dopant is a metal selected from Cu, Ag, Au, Mn, Zn, or combinations thereof.", "In some or both of these embodiments, the shell is a ZnS or chloride shell.", "Also disclosed herein are embodiments of compositions, comprising: a composite having a core comprising one or more magnetic nanoparticles, one or more quantum dots, or a combination thereof and a zwitterionic polymeric coating comprising a zwitterionic polymer having a structure satisfying a formula wherein each R1 independently is selected from hydrogen or aliphatic; each R2 is —C(O)Z, wherein Z is selected from hydroxyl, ether, amine, thiol, or thioether; each R3 independently is selected from amide-aliphatic-amine, amide-aliphatic-amine-aliphatic-carboxylate, amide-aliphatic-amine-aliphatic-sulfonate, or amide-aliphatic-thiol; p is an integer selected from zero to 5; q is an integer selected from zero or 1; and each of a and b independently is an integer selected from 1 to 200; and a biomolecule, a drug, or a combination thereof.", "In some embodiments, the core further comprises a dopant, a shell, or both.", "In some or both of these embodiments, the dopant is a metal selected from Cu, Ag, Au, Mn, Zn, or combinations thereof.", "In any or all of the above embodiments, the shell is a ZnS or a chloride shell.", "In any or all of the above embodiments, the biomolecule is conjugated to the composite.", "In any or all of the above embodiments, the biomolecule is chemically conjugated to the composite through the zwitterionic polymeric coating.", "In any or all of the above embodiments, the biomolecule is chemically conjugated to the composite through a carboxylate group of the zwitterionic polymeric coating.", "In some embodiments, the carboxylate group of the zwitterionic polymeric coating is further chemically bound to a linker, wherein the linker is also chemically bound to the biomolecule.", "In any or all of the above embodiments, the biomolecule is selected from chlorotoxin, avidin, biotin, folic acid, arginylglycylaspartic acid, or combinations thereof.", "In any or all of the above embodiments, the drug is encapsulated within the zwitterionic polymeric coating.", "In any or all of the above embodiments, the drug is doxorubicin, daunorubicin, epirubicin, idarubicin, or a combination thereof.", "Also disclosed herein are embodiments of methods for making a composite, comprising: combining, to form a mixture, a solution comprising one or more magnetic nanoparticles, one or more quantum dots, or a combination thereof with a solution of a zwitterionic polymer having a structure satisfying a formula wherein each R1 independently is selected from hydrogen or aliphatic; each R2 is —C(O)Z, wherein Z is selected from hydroxyl, ether, amine, thiol, or thioether; each R3 independently is selected from amide-aliphatic-amine, amide-aliphatic-amine-aliphatic-carboxylate, amide-aliphatic-amine-aliphatic-sulfonate, or amide-aliphatic-thiol; p is an integer selected from zero to 5; q is an integer selected from zero or 1; and each of a and b independently is an integer selected from 1 to 200; dispersing the mixture into water using sonication to form a dispersed composition; and isolating the composite from the dispersed composition.", "In any or all of the above embodiments, the method further comprises centrifuging the dispersed composition to remove non-composite by-products.", "Also disclosed herein are embodiments of methods for making a quantum dot, comprising: combining a Group 11 metal precursor with a Group 13 metal precursor, one or more ligands, a solvent, or a combination thereof to form a precursor mixture; and heating the precursor mixture to a temperature sufficient to facilitate formation of the quantum dot.", "In any or all of the above embodiments, the Group 11 metal precursor is a copper-containing precursor, a silver-containing precursor, or a combination thereof.", "In any or all of the above embodiments, the Group 11 metal precursor is copper acetate, silver acetate, or a combination thereof.", "In any or all of the above embodiments, the Group 13 metal precursor comprises indium.", "In any or all of the above embodiments, the Group 13 metal precursor is indium acetate.", "In any or all of the above embodiments, a metal molar ratio of Ag:In of 1:2 or a metal molar ratio of Cu:In of 1:2 is used.", "In any or all of the above embodiments, the temperature ranges from 150° C. to 200° C. In any or all of the above embodiments, the temperature is 170° C. In some embodiments, the methods comprise combining copper acetate, silver acetate, or a combination thereof with indium acetate, oleic acid, and dodecanethiol to form a precursor mixture; and heating the precursor mixture to a temperature ranging from 160° C. to 180° C. to facilitate formation of a CuInS2 quantum dot, an AgInS2 quantum dot, or a combination thereof.", "Embodiments of methods of imaging cells also are disclosed herein, with such methods comprising: contacting a cell with an imaging amount of the composite having a core comprising one or more magnetic nanoparticles, one or more quantum dots, or a combination thereof and a zwitterionic polymeric coating comprising a zwitterionic polymer having a structure satisfying a formula wherein each R1 independently is selected from hydrogen or aliphatic; each R2 is —C(O)Z, wherein Z is selected from hydroxyl, ether, amine, thiol, or thioether; each R3 independently is selected from amide-aliphatic-amine, amide-aliphatic-amine-aliphatic-carboxylate, amide-aliphatic-amine-aliphatic-sulfonate, or amide-aliphatic-thiol; p is an integer selected from zero to 5; q is an integer selected from zero or 1; and each of a and b independently is an integer selected from 1 to 200; or a composition comprising the composite and a biomolecule, a drug, or both; and detecting cellular update and/or the location of the composite in the cell.", "In any or all of the above embodiments, detecting the location of the composite comprises exposing the cell to a stain and visually imaging the cell to detect cellular uptake of the composite.", "In any or all of the above embodiments, detecting the location of the composite comprises analyzing the cell using photoluminescence spectroscopy to determine the photoluminescent intensity of the composite.", "Also disclosed herein are embodiments of a method of delivering a therapeutic drug to a subject, comprising: contacting the subject with a therapeutically effective amount of a composition comprising the therapeutic drug and a composite having a core comprising one or more magnetic nanoparticles, one or more quantum dots, or a combination thereof and a zwitterionic polymeric coating comprising a zwitterionic polymer having a structure satisfying a formula wherein each R1 independently is selected from hydrogen or aliphatic; each R2 is —C(O)Z, wherein Z is selected from hydroxyl, ether, amine, thiol, or thioether; each R3 independently is selected from amide-aliphatic-amine, amide-aliphatic-amine-aliphatic-carboxylate, amide-aliphatic-amine-aliphatic-sulfonate, or amide-aliphatic-thiol; p is an integer selected from zero to 5; q is an integer selected from zero or 1; and each of a and b independently is an integer selected from 1 to 200.In any or all of the above embodiments, therapeutic drug is encapsulated within the zwitterionic polymeric coating.", "In any or all of the above embodiments, the drug is doxorubicin, daunorubicin, epirubicin, idarubicin, or a combination thereof.", "VII.", "Examples Materials Poly(maleic anhydride-alt-1-octadecene (PMAO, average Mn 30000-50000), 3-(dimethylamino)-1-propylamine (DMAPA, 99%), N,N-diisopropylethylamine (DIPEA, 99.5%), β-propiolactone (Grade II, ≥90%), gelatin, and poly-D-lysine (PDL) were purchased from Sigma-Aldrich.", "1,3-propanesultone (99%) was purchased from Alfa Aesar.", "Tetrahydrofuran (THF, >99%), ethanol (>99%), methanol (>99%), dichloromethane and chloroform (>99.9%) were purchased from Pharmco-AAPER.", "U-87 MG (HTB-14) and HEK-293 cells (CRL-1537) were ordered from the American Type Culture Collection (ATCC).", "RPMI-1640, MEM and DMEM media were from Corning Cellgro.", "Paraformaldehyde, Dulbecco's phosphate buffered saline (DPBS), and phosphate buffered saline (PBS) were from Fisher Scientific.", "Heat-inactivated fetal bovine serum (FBS) and stempro accutase were from Gibco.", "Bovine serum albumin (BSA) was from MP Biomedicals.", "Chlorotoxin (CTX) was purchased from Alomone Labs.", "Fluorescein diacetate (FDA), propidium iodide (PI), 4′,6-diamidino-2-phenylindole (DAPI) were was from Pierce.", "All chemicals or reagents were used as received without further purification.", "The infrared (IR) spectra were acquired using a Perkin-Elmer Frontier FT-IR spectrometer equipped with Spectrum 10 software and Universal ATR sampling accessory.", "The nuclear magnetic resonance (NMR) spectra were obtained on Varian VNMRS operating at 500 MHz (′H) and 298K.", "For the zwitterionic magnetofluorescent nanoparticle preparation, a probe-type Misonix Ultrasonic Liquid Processor (QSonica) was used.", "Transmission electron microscope (TEM) images and Energy-dispersive X-ray (EDX) spectra were acquired using a JEOL analytical transmission electron microscope (model JEM 2100F) operated with a 200 kV acceleration voltage and equipped with an Oxford Energy-Dispersive X-ray (EDX) spectrometer.", "The optical characteristics of zwitterionic magnetofluorescent nanoparticles including ultraviolet-visible (UV-Vis) and photoluminescence spectra were collected using Shimadzu UV-2450 spectrometer and Shimadzu RF-5301PC spectrofluorometer.", "The hydrodynamic sizes were measured in H2O using a Malvern Zetasizer Nano ZS dynamic light scattering (DLS) instrument equipped with a HeNe laser operating at 632.8 nm and a scattering detector at 173 degrees.", "For iron content assay and colloidal stability embodiments, a Perkin-Elmer microplate reader was used.", "Cell viability or cytotoxicity were estimated using a BD Biosciences SORP LSR II flow cytometer with 4 lasers (405 nm, 488 nm, 561 nm and 640 nm) and 18 fluorescence detectors.", "Magnetic resonance imaging was performed on a Bruker BioSpec 7T horizontal bore system.", "Fluorescent cellular images were taken using Leica TCS SP8 (DM 6000 CS) confocal scanning microscope.", "Preparation of Zwitterionic Amphiphiles Generally, the synthesis of zwitterionic amphiphilic polymer PMAO-carboxybetaine-sulfobetaine involved two steps.", "In the first step, PMAO anhydride rings were opened by the primary amine groups of DMAPA leading to the presence of terminal carboxyl and tertiary amine groups on the polymer backbone.", "In the second step, tertiary amines reacted with β-propiolactone and 1,3-propanesultone to form carboxybetaine and sulfobetaine groups, respectively.", "To avoid possible ring-opening polymerization of β-propiolactone and/or 1,3-propanesultone, the second-step reaction was started in ice-bath and the total molarity of both β-propiolactone and 1,3-propanesultone was controlled to be slightly higher than that of tertiary amines (if all anhydride rings in PMAO were opened).", "Of note, although the molar ratio between β-propiolactone and 1,3-propanesultone can be tuned, in this embodiment an 1:1 ratio of them was used to demonstrate the proof of concept on PMAO-carboxybetaine-sulfobetaine.", "The synthesis is simple, and its production yield is >80%.", "In one example, PMAO-DMAPA was first prepared by stirring the mixture of 2.02 g PMAO and 1.1 mL DMAPA in 25 mL CH2Cl2 over ice-bath for 3 hours followed by precipitation of the product by adding acetone.", "The white precipitate was collected by filtration and then washed 3 times (with sonication) by dissolving in ˜15-20 mL CHCl3 and precipitating with acetone (3 times volume excess).", "The product was dried under vacuum overnight resulting in 2.03 g (˜77% yield) of PMAO-DMAPA.", "For the synthesis of PMAO-DMAPA-carboxybetaine-sulfobetaine, the mixture of 0.50 g PMAO-DMAPA, 192 μL DIPEA, 38.4 μL of β-propiolactone, and 68.2 mg 1,3-propanesultone in 5 mL CH2Cl2 was stirred over ice-bath for ˜3 hours and then at room temperature overnight.", "The resulting lightly cloudy mixture was pipetted into centrifuge tubes and washed (>5 times) by dissolving in ˜1 mL CHCl3-MeOH (1:1, v/v), precipitating with acetone (3-5 times volume) and collecting the precipitate by centrifugation.", "The white solid was dried under vacuum overnight giving 0.54 g of product (˜88% yield).", "The synthesized PMAO derivatives were characterized by FTIR, as shown in FIG.", "2.PMAO-DMAPA spectrum showed the disappearance of anhydride C═O at around 1857 cm−1 and 1776 cm−1 and the appearance of new peaks at around 1713 cm−1 for carboxyl C═O, around 1649 cm−1 for amide C═O, and around 1560 cm−1 for amide N—H, which indicates the addition of DMAPA to PMAO.", "In the spectrum of PMAO-carboxybetaine-sulfobetaine, the peaks from PMAO-DMAPA are represented and some new peaks at around 1175 cm−1 and 1035 cm−1 are observed.", "As shown in FIG.", "3, the peaks at around 1175 cm−1 and 1035 cm−1 are also observed in the FTIR spectrum of amidosulfobetaine-16 (ASB-16) which is an alkyl chain with a sulfobetaine head.", "These two peaks represent S═O in the sulfo group.", "The spectrum comparison and analysis indicates the formation of sulfobetaine after the reaction of the tertiary amines of PMAO-DMAPA with 1,3-propanesultone.", "Peaks associated with carboxybetaine in PMAO-carboxybetaine-sulfobetaine are not significant for observation, probably because the peaks for the additional carboxyl C═O from the formed carboxybetaine groups in PMAO-carboxybetaine-sulfobetaine are overlapping with those of the existing carboxyl C═O in PMAO-DMAPA.", "However, a slight distortion at around 1590 cm−1 in the spectrum of PMAO-carboxybetaine-sulfobetaine (not marked but close to the mark line at 1560 cm−1) is still distinguishable.", "Considering there is a significant peak at around 1590 cm−1 for N-Dodecyl-N,N-(dimethylammonio)butyrate (DDMAB) which is an alkyl chain with a carboxybetaine head (as shown in FIG.", "1), this minor distortion may suggest the addition of carboxybetaine to PMAO.", "The synthesized PMAO derivatives dissolved in a mixture of CDCl3 and CD3OD were further characterized using NMR.", "All NMR spectra were presented in FIG.", "5.For all samples, the hydrophobic alkyl chain (C18) of the polymer was observed at 0.80 ppm for —CH3 and 1.18 ppm for —CH2.For PMAO-DMAPA, two additional peaks are presented at 2.66 ppm and 1.76 ppm.", "In literature, the following peaks have been reported for the attachment of DMAPA to polymer backbones: C(O)NHCH2 at 3.2-3.3 ppm, CH2N(CH3)2 at 2.36 ppm, N(CH3)2) at 2.2 ppm, CH2CH2N(CH3)2 at 1.6 ppm.", "The observed peaks due to the addition of DMAPA to PMAO appear in the chemical shift range as reported in the literature for the same chemical group.", "For PMAO-carboxybetaine-sulfobetaine, it has two peaks at 1.88 ppm and 2.75 ppm (similar to these of PMAO-DMAPA), but have an additional peak at around 3.02 ppm.", "Literature has reported the following peaks due to the carboxybetaine addition to polymer backbones: C(O)NHCH2 at 2.75-3.48 ppm, C(O)NHCH2CH2 at 1.55-2 ppm, CH2N+(CH3)2 at 2.75-3.48 ppm, N+(CH3)2 at 2.9-3.3 ppm, CH2CH2COO− at 3.4-3.55 ppm, CH2COO− at 2.25-2.75 ppm; and the follow peaks due to the sulfobetaine addition to polymer backbones: C(O)NHCH2 at 3.2 ppm, C(O)NHCH2CH2 at 1.9 ppm, CH2N+(CH3)2 at 3.3 ppm, N+(CH3)2 at 3.05-3.1 ppm, CH2CH2CH2SO3− at 3.4 ppm, CH2CH2SO3− at 2.15 ppm, and CH2CH2SO3− at 2.89 ppm.", "The peaks for PMAO-carboxybetaine-sulfobetaine match with what were reported.", "For the synthesis of PMAO-DMAPA-CBSB, PMAO-DMAPA (0.50 g) was first dissolved in 5 mL of anhydrous CHCl3 and then cooled over ice-H2O bath.", "Then, DIPEA (192 μL, 1.1 mmole) was added and the mixture stirred for 5 minutes before adding β-propiolactone (38.4 μL, 0.55 mmole), and 1,3-propanesultone (67.9 g, 0.55 mmole).", "The reaction mixture was stirred over ice-H2O bath for 3 hours and then at room temperature overnight.", "The resulting lightly cloudy mixture was pipetted into centrifuge tubes and washed (7×) by dissolving in ˜1 mL CHCl3-MeOH (1:1, v/v), precipitating with acetone (3-5× volume) and collecting the precipitate by centrifugation.", "The white solid was dried under vacuum overnight giving 0.54 g of product.", "For the alternative approach for the introduction of carboxybetaine group, PMAO-CBtBu was first prepared by stirring the mixture of PMAO-DMAPA (0.50 g), DIPEA (0.40 mL, 2.3 mmol), and tert-butyl bromoacetate (0.52 mL, 3.4 mmole) in 5 mL of anhydrous CHCl3 at room temperature overnight.", "The clear reaction mixture was poured into 50 mL anhydrous Et2O to precipitate the product.", "The white precipitate was collected and washed with 15 mL Et2O (3×) and dried under vacuum giving 1.0 g of product.", "As the product weighed more than expected, it was re-washed with 10 mL acetone (3×), but much less solid was isolated and the product was found to have dissolved in acetone, as solids were collected after rotary evaporation of the acetone filtrate (0.96 g).", "The product isolated from evaporation of acetone was used without further purification for the next reaction.", "It was stirred with 1.2 mL TFA under Argon for 1 h to hydrolyze the tert-butyl ester group.", "The product (PMAO-CB) was precipitated and washed with anhydrous Et2O, and then dried under vacuum (0.63 g) and further washed with acetone giving 0.55 g of white solid after drying.", "In some embodiments, amino intermediates comprising CB and SB units can be made and then used to open maleic anhydride-containing polymers.", "The primary amine of DMAPA was first protected by reaction with di-tert-butyl dicarbonate (Boc anhydride) to obtain Boc-DMAPA.", "The reaction of Boc-DMAPA with β-propiolactone (or 1,3-propanesultone) was followed by acid treatment to remove the protecting group and obtain the corresponding acid salt of amino-CB (or amino-SB).", "The obtained intermediates were characterized by 1H NMR spectroscopy and confirmed by comparison with literature data when available.", "The obtained Boc-DMAPA was reacted with 1,3-propanesultone, which was followed by acid hydrolysis of Boc protecting group to get the corresponding acid salt of amino-SB.", "The 1H NMR of the product showed the disappearance of the signal at 1.44 ppm (compared with Boc-DMAPA) which indicates the removal of the Boc protecting group.", "The proton peaks were also assigned as indicated below.", "The products/intermediates for the synthesis of amino-SB were also characterized by FTIR spectroscopy.", "The addition of 1,3-propanesultone to Boc-DMAPA is indicated by the more prominent peaks at 1163 cm−1 (overlapping with C—N vibration) and 1033 cm−1 for S═O of the sulfonic group.", "The removal of the Boc protecting group is confirmed by the disappearance of the peaks at 1694 cm−1 and 1528 cm−1 from the C═O and N—H, respectively, of Boc-DMAPA.", "The amino-CB was alternatively prepared from the reaction between Boc-DMAPA and tert-butyl bromoacetate, which is eventually followed by acid hydrolysis of the tert-butyl groups to give the corresponding acid salt of amino-CB.", "The 1H NMR spectrum of the product showed the disappearance of the tert-butyl groups at 1.54 and 1.45 ppm, indicating the deprotection (removal of Boc and tert-butyl ester groups) by acid hydrolysis.", "The isolated products/intermediates for amino-CB were also characterized by FTIR spectroscopy.", "For the reaction of Boc-DMAPA and t-butyl bromoacetate, the appearance of overlapping peaks at 1740 cm−1 and 1691 cm−1 are for the C═O of butyl ester and the C═O of Boc group, respectively.", "The peaks at 1249 cm−1 and 1152 cm−1 are for the C—O vibration of the t-butyl ester group which disappeared after removal of the protecting groups via HCl hydrolysis, along with the peak at 1691 cm−1 from removal of Boc protecting group.", "The C═O for amino-CB (acid salt) is found to have shifted to 1740 cm−1 corresponding to that for carboxylic acid.", "The broad peak at 2800 cm−1, aside from containing the C—H, also represents the O—H from the carboxylic group.", "The protection of the primary amine of DMAPA was done by stirring (under Ar) the solution of DMAPA (5 mL, 39.3 mmole) in 21 mL anhydrous MeOH and di-tert-butyl dicarbonate (Boc anhydride, 9.6 mL, 41.4 mmole) over ice/H2O bath for at least 1 hour and then allowing mixture to reach room temperature and continued stirring overnight.", "Bubbling (from formation of CO2) occurred during the addition of Boc anhydride.", "The resulting clear, colorless solution was concentrated by rotary evaporation, dissolved in 30 mL H2O, and then washed with EtOAc (25 mL×5).", "The combined EtOAc washes was dried over anhydrous Na2SO4, filtered to remove the drying agent, and the filtrate concentrated by rotary evaporation.", "The residue was dried under vacuum giving 5.64 g (71% yield) of colorless oil.", "To synthesize the sulfobetaine intermediate, Boc-DMAPA (2.51 g, 12.4 mmole) was dissolved in 15 mL of anhydrous DMF and then 1.56 mL (2.13 g, 17.4 mmol) of 1,3-propanesultone (1.56 mL, 17.4 mmole) was added.", "The clear, colorless solution was stirred at room temperature for 2 days.", "The resulting clear reaction mixture was added to 100 mL of anhydrous Et2O to precipitate the product, which came out as viscous material.", "After cooling the mixture in the freezer for 1 hour, the lightly cloudy supernatant was decanted.", "The wash was repeated (2 more times) by dissolving the residue in MeCN, adding Et2O, cooling in the freezer, and decantation of the supernatant.", "The viscous residue was transferred into a pre-weighed flask using MeCN, concentrated by rotary evaporation, and dried under vacuum overnight giving 4.51 g (112% yield) of white, foamy residue.", "The sample was re-washed using MeCN and Et2O (3×) resulted to 4.39 g (109% yield) of foamy residue after drying.", "Although the sample weighed more than expected, it was used as is for the acid hydrolysis of the Boc protecting group using aqueous HCl.", "Boc-DMAPA-SB (4.15 g, 12.8 mmole) was dissolved in 11 mL of H2O and 5.3 mL of concentrated HCl (˜5× excess) was added, during which bubbling occurred.", "The mixture was stirred (loosely stoppered) at room temperature overnight.", "The sample was concentrated by rotary evaporation (remaining HCl/H2O was co-evaporated with 10 mL Et2O (3×)) and the residue dried under vacuum giving 4.21 g of viscous residue.", "The product was re-stirred with 30 mL of 4 M HCl in MeOH for 4 hours, concentrated with rotary evaporation (with Et2O co-evaporation) and then dried under vacuum giving 4.67 g of faintly yellow oil.", "The sample was used as is for reaction with PMAO.", "For the remaining sample, several trials were done to isolate the HCl salt as a solid.", "Eventually, the sample (3.34 g) was dissolved in 10 mL MeOH and CH2C12/iPrOH/MeOH (10:5:1, volume ratio) was added in portions (used 45 mL) at which a solid mass collected at the bottom of the flask.", "The sample was washed with CH2C12/iPrOH/MeOH (10:5:1, volume ratio) and after drying under vacuum a white solid was obtained.", "The sample was transferred into a fitted funnel by repeatedly washing with CH2C12/iPrOH/MeOH (10:5:1, volume ratio) (with sonication), and after drying under vacuum, 2.04 g of white solid was obtained.", "For the synthesis of the carboxybetaine intermediate, Boc-DMAPA (1.26 g, 6.23 mmole) was dissolved in 6 mL anhydrous MeCN and then tert-butyl bromoacetate (1.31 mL, 8.72 mmole) was added.", "The mixture was stirred at 50° C. (oil bath temperature) for 24 hours.", "After cooling to room temperature, the reaction mixture was added to Et2O to precipitate the product, which came out as viscous residue.", "The mixture was cooled in the freezer for 1 hour and the supernatant was decanted.", "The wash was repeated (2 more times) by dissolving the residue in MeCN and adding Et2O.", "The residue was transferred into a pre-weighed flask using MeCN, concentrated by rotary evaporation, and then dried under vacuum overnight giving 2.32 g of white, foamy residue.", "The product was used as is for the next reaction, which is the acid hydrolysis of Boc and t-Bu ester groups using aqueous HCl.", "Boc-DMAPA-CB-tBuester (2.17 g) was dissolved in 10 mL of H2O and 4.6 mL of concentrated HCl (˜5× excess) was added, during which bubbling occurred.", "The mixture was stirred (loosely stoppered) at room temperature for 2 hours.", "The mixture was concentrated by rotary evaporation (with Et2O co-evaporation) and then dried under vacuum giving 1.58 g of viscous residue.", "The NMR spectrum showed that the Boc and t-Bu groups were gone.", "In the attempt to recover the product as a solid, the sample was re-stirred with 15 mL of 4M HCl in MeOH for 2 hours, concentrated by rotary evaporation (with Et2O co-evaporation), and rinsed with acetone.", "After drying under vacuum, solid sample was obtained.", "The sample was transferred into a fritted funnel by repeated washing (with sonication) with Et2O and then CH2C12/iPrOH/MeOH (10:5:1, volume ratio) and then dried under vacuum giving 0.99 g of white solid.", "For the synthesis of PMAO-CBSB, PMAO (100 mg, 2.5 μmole, ˜285 μmole anhydride) was dissolved in 5 mL anhydrous CHCl3.In a separate container, amino-SB (HCl salt, 42 mg) and amino-CB (HCl salt, 33 mg) were mixed with 500 μL anhydrous MeOH (some undissolved solid present).", "DIPEA (300 μL) was added to convert the intermediates to the free base form, resulting in a clear, colorless solution.", "The solution of amino-SB and amino-CB was added to PMAO and the mixture stirred at room temperature for 24 hours.", "The reaction mixture was concentrated by rotary evaporation and the residue dissolved in CHCl3-MeOH (1:1, v/v).", "The product was precipitated by adding acetone and collected by centrifugation.", "The dissolution in CHCl3-MeOH and precipitation with acetone was repeated 2 more times and the residue dried under vacuum giving 144 mg of white solid.", "Preparation of Zwitterionic Magnetofluorescent Nanoparticles On the basis of the synthesized PMAO-carboxybetaine-sulfobetaine, zwitterionic magnetofluorescent nanoparticles integrating small MnFe2O4 magnetic nanoparticles and CuInS2/ZnS quantum dots in the micellar cores were fabricated.", "Magnetic nanoparticles and quantum dots were around 5 nm.", "Using the disclosed methods to produce composites comprising quantum dots, the quantum dot photoluminescence can be tuned from 650 nm-800 nm (FIG.", "4).", "In one example, CuInS2 quantum dots with around 720 nm photoluminescence emission were prepared, and after ZnS shell growth the CuInS2/ZnS quantum dots emit photoluminescence at around 685 nm.", "A solution of 0.6 mg MnFe2O4 magnetic nanoparticles and 2.4 mg CuInS2/ZnS quantum dots in THF (900 μL) and 1.7 mg PMAO-carboxybetaine-sulfobetaine in CHCl3-MeOH (˜50 μL) was layered on top of cold water in a glass vial.", "The mixture was ultrasonicated using the Misonix Ultrasonic Liquid Processor with a 5 W output power for 1 minute.", "After sonication, the organic solvents were removed by rotary evaporation at room temperature and the sample filtered through a 0.2 μm syringe filter.", "Empty micelles or single-nanoparticle based micelles were removed by centrifugation at 18,000 rpm for 25 min (twice).", "The collected zwitterionic magnetofluorescent nanoparticles were dispersed in 400 μL of water, and stored at 4° C. until further use.", "The fabricated zwitterionic magnetofluorescent nanoparticles were characterized using TEM and EDXS.", "FIGS.", "6A and 6B present TEM images of zwitterionic magnetofluorescent nanoparticles, and the images indicate the sizes of zwitterionic magnetofluorescent nanoparticles in around 50˜60 nm.", "On the basis of TEM imaging, the overall size of zwitterionic magnetofluorescent nanoparticles mostly distributed over a range of 20˜150 nm was observed.", "EDX analysis in FIG.", "6C further demonstrates that zwitterionic magnetofluorescent nanoparticles are composed of Mn, Fe, O, Cu, In, Zn and S elements.", "In addition to TEM, DLS data of zwitterionic magnetofluorescent nanoparticles have been collected and presented in Table 1.The hydrodynamic sizes of zwitterionic magnetofluorescent nanoparticles are 99 nm with a standard deviation at 60 nm.", "The zwitterionic magnetofluorescent nanoparticle hydrodynamic sizes mainly are contributed by the micelle hydrophobic core (imaged by TEM), the polymer shell, and the hydration layer caused by zwitterions on the polymer shell.", "The (Mn+Fe) content in zwitterionic magnetofluorescent nanoparticles was also quantified on the basis of the iron content determination of zwitterionic magnetofluorescent nanoparticles using thiocyanate colorimetry.", "Table 1 also shows that the (Mn+Fe) recovery rate for 0.6 mg magnetic nanoparticles input to zwitterionic magnetofluorescent nanoparticles is as high as around 60%.", "TABLE 1 Hydrodynamic sizes and (Mn + Fe) recovery rates of zwitterionic magnetofluorescent nanoparticles and zwitterionic magnetic nanoparticles Hydrody- (Mn + Fe) namic sizes recovery rates Particles (nm) (%) zwitterionic 99 ± 60 62 ± 1 magnetofluorescent nanoparticles zwitterionic magnetic 133 ± 69 60 ± 4 nanoparticles The photoluminescence spectrum of zwitterionic magnetofluorescent nanoparticles is shown in FIG.", "7A, compared to that of quantum dots in organic solvents.", "The photoluminescence intensities are scaled by the quantum yield of zwitterionic magnetofluorescent nanoparticles relative to that of hydrophobic quantum dots in THF (the measured quantum yields of zwitterionic magnetofluorescent nanoparticles are <10%).", "It can be seen that the photoluminescence of zwitterionic magnetofluorescent nanoparticles is significantly quenched.", "The quenching may be caused by the MNP absorption on quantum dot emissions, or by the reduction of quantum dot excitation/emission surfaces due to the blocking effect of surrounding magnetic nanoparticles.", "FIGS.", "7A and 7B also show that the overall photoluminescence property of zwitterionic magnetofluorescent nanoparticles are tunable by adjusting the MNP:quantum dot mass ratio in the fabrication process.", "Additional embodiments are illustrated in FIGS.", "8A and 8B.", "The absorbance of the prepared zwitterionic magnetofluorescent nanoparticles was characterized using a UV-Vis spectrophotometer, as shown in FIG.", "9.No significant difference on UV-Vis absorbance curves was observed for all fabricated zwitterionic magnetofluorescent nanoparticles.", "The magnetic imaging features of magnetofluorescent nanoparticles were characterized using a magnetic resonance imaging (MRI) instrument (Bruker BioSpec).", "The MR images of zwitterionic magnetofluorescent nanoparticles were acquired with a conventional spin echo acquisition (TR=6000 ms) with TE values ranging from 9.5 ms to 190 ms. T2 parameter (or R2 parameter, R2=1/T2) of zwitterionic magnetofluorescent nanoparticles was extracted by fitting the exponential decay of the signal waveform and measuring the signal intensity at a series of different TE values.", "FIG.", "7B presents R2 parameter (or 1/T2) of zwitterionic magnetofluorescent nanoparticles vs (Mn+Fe) concentration.", "The relaxivity (r2) of zwitterionic magnetofluorescent nanoparticles was calculated as the slope of the R2 curve.", "The relaxivity r2 value of zwitterionic magnetofluorescent nanoparticles is around 150 mM−1s−1.R2 parameter of zwitterionic magnetic nanoparticles (using magnetic nanoparticles and the synthesized zwitterionic amphiphiles but not containing any quantum dots) also was measured as a comparison.", "The relaxivity r2 of zwitterionic magnetic nanoparticles is around 266 mM−1s−1.In literature, T2 parameter of agglomerated nanomagnet clusters has been formulated and discussed.", "Briefly, for agglomerated nanomagnets, 1/T2=16faΔω2τD/45 with fa being the volume fraction occupied by the agglomerated nanomagnets, Δω=μoMγ/3 (where μo is the vacuum magnetic permeability, M is the particle magnetization, and γ is the proton gyromagnetic ratio), and τD is the translational diffusion time around the cluster (τD=Ra2/D where Ra being the cluster radius and D being the water diffusion coefficient).", "Although the formula of T2 parameter discussed for the agglomerated system is built only on small magnetic nanoparticles, it can be applicable to zwitterionic magnetofluorescent nanoparticles with a mixture of quantum dots and magnetic nanoparticles.", "Specifically, fa probably can be re-defined as the volumic fraction occupied by magnetic nanoparticles in zwitterionic magnetofluorescent nanoparticles.", "Considering zwitterionic magnetofluorescent nanoparticles and zwitterionic magnetic nanoparticles have the similar size ranges (as shown in Table 1), the increase of quantum dots over magnetic nanoparticles in the fabrication may cause the decrease of fa, which further result in the total net magnetization (M) of zwitterionic magnetofluorescent nanoparticles to drop.", "Thus, quantum dots involved in the fabrication cause R2 and thus r2 decrement of zwitterionic magnetofluorescent nanoparticles.", "In spite of the R2 or r2 drop, the relaxivity value for zwitterionic magnetofluorescent nanoparticles is still comparable to many reported ones.", "Of note, the fabricated zwitterionic magnetic nanoparticles also can be considered as excellent contrasts for MRI because of their high magnetic relaxivity and (Mn+Fe) recovery rate.", "Cell Cytotoxicity of Magnetofluorescent Nanoparticles In biosensing/imaging applications, aggregation of zwitterionic magnetofluorescent nanoparticles will cause the degradation or even loss of their physiochemical and biological functionalities, and thus zwitterionic magnetofluorescent nanoparticles are expected to have excellent colloidal stability.", "The photoluminescence intensity of zwitterionic magnetofluorescent nanoparticles dispersed in PBS-5% FBS with pH 4-9, a 1 M NaCl-5% FBS and human serum was monitored over 72 hours at 37° C. using a microplate reader, and presented in FIG.", "10.With reference to FIG.", "10, the different time periods included in the legend correspond to different bars present for each pH value shown on the graph, as read from left to right for the time and for each bar.", "That is, each group of bars for each pH value is ordered by increasing time period from left to right.", "For example, the left-most bar of each pH bar set corresponds to 1 hour and the right most bar of each pH bar set corresponds to 72 hours.", "The photoluminescence intensity and hence stability of these zwitterionic magnetofluorescent nanoparticles was maintained in all these conditions.", "Moreover, no precipitates or significant photoluminescence intensity decreases were observed over one week at 37° C. Stored at 4° C., the zwitterionic magnetofluorescent nanoparticles were also found to be stable in water at over at months (FIGS.", "11 and 12).", "As with FIG.", "10, each group of bars shown in FIGS.", "11 and 12 includes one bar for each different time period provided by the legend, and time periods are organized in increasing order so that each bar from left to right corresponds to an increased time period (e.g., the left-most bar of each group represents a time period of 1 hour and the right-most bar of each group represents week 10).", "The excellent stability of these zwitterionic magnetofluorescent nanoparticles in these conditions especially in a solution with pH4, a solution with 1M salinity, and serum, is very attractive.", "Carboxybetaine groups and sulfobetaine groups coated on the surface of zwitterionic magnetofluorescent nanoparticles should be attributed to this stability.", "These zwitterions facilitate a hydration layer coating on zwitterionic magnetofluorescent nanoparticles, and the hydration layer is very stable and almost remains unperturbed under harsh conditions such as high/low pH values, high salinity, and complex matrix.", "The stability of zwitterionic magnetofluorescent nanoparticles offers a great deal of flexibility for their biomedical applications.", "The cytotoxicity of the zwitterionic magnetofluorescent nanoparticles was studied using human primary glioblastoma cells (U-87 MG) and human embryonic kidney 293 cells (HEK-293).", "U-87 MG and HEK-293 represent tumor cells and normal cells, respectively.", "FIGS.", "13A and 13B show the measured cell viabilities for U-87 MG and HEK-293 after 24-hour incubation with zwitterionic magnetofluorescent nanoparticles under different concentrations, respectively.", "With reference to FIGS.", "13A and 13B, each bar of the different bar groups represents a different MNP:quantum dot ratio, with each left-most bar representing an MNP:QD of 1:1, each middle bar representing an MNP:QD of 1:2, and each right-most bar representing an MNP:QD of 1:4.An additional embodiment is illustrated in FIG.", "14.With reference to FIG.", "14, the left-most bar of each bar group represents the data for U-87 MG cells, and the right-most bar of each bar group represents the data for HEK-293 cells.", "It can be seen that the cell viabilities under different particle concentrations are comparable to controls, and thus the zwitterionic magnetofluorescent nanoparticles are biocompatible and their cytotoxicity is minimal.", "In one example, A U-87 MG human brain glioblastoma cell line was cultured (37° C., 5% CO2) on 24-well plastic plates in MEM medium with 10% FBS overnight.", "The human embryonic kidney cell line HEK-293 was cultured (37° C., 5% CO2) on 24-well plastic plates in RPMI-1640 medium with 10% FBS overnight.", "For the zwitterionic magnetofluorescent nanoparticle cytotoxicity examples, cells were incubated with zwitterionic magnetofluorescent nanoparticles in growth medium at various concentrations.", "After 24-hour incubation, cells were gently rinsed with DPBS and released from well bottom using stempro accutase, and then stained with FDA and PI to determine live versus dead cells.", "Dead cells (red staining by PI) and live cells (green staining by FDA) were counted using a BDBiosciences SORP LSR II flow cytometer.", "The cell viability was calculated as the ratio of live cells over the sum of live cells and dead cells.", "Conjugation of Composites with Neutravidin for Avidin-Biotin Binding Assay To verify that zwitterionic magnetofluorescent nanoparticles are capable for bioconjugation, zwitterionic magnetofluorescent nanoparticles with a MNP:quantum dot mass ratio at 1:4 were fabricated and conjugated with Neutravidin using regular EDC/NHS cross-linker.", "The conjugated zwitterionic magnetofluorescent nanoparticles were then incubated with biotinylated magnetic microbeads (˜4 μm in diameter).", "After incubation, microbeads were washed and their fluorescence was measured.", "FIG.", "15 shows the fluorescence responses of the microbeads after their incubation with serial dilutions of Neutravidin-conjugated zwitterionic magnetofluorescent nanoparticles (FIG.", "15, right-most bars of each bar group) from the stock suspension (or with different concentrations).", "As controls, the fluorescence responses of the biotinylated magnetic microbeads after their incubation with non-conjugated zwitterionic magnetofluorescent nanoparticles (FIG.", "15, left-most bars of each bar group) under the same dilutions were measured.", "For each dilution or concentration, the fluorescence response for non-conjugated zwitterionic magnetofluorescent nanoparticles is clearly lower than that of conjugated zwitterionic magnetofluorescent nanoparticles.", "Thus, zwitterionic magnetofluorescent nanoparticles can be covalently conjugated with biomolecules.", "In addition, the assay result indicates that the nonspecific binding (NSB) of non-conjugated zwitterionic magnetofluorescent nanoparticles to microbeads is very low.", "The low NSB may be attributed to the nature of zwitterion (for example, the hydration layer of zwitterions makes zwitterionic magnetofluorescent nanoparticles more hydrophilic and minimizes the electrostatic or hydrophobic absorption of zwitterionic magnetofluorescent nanoparticles on the reaction surface).", "In one example, zwitterionic magnetofluorescent nanoparticles with the MNP:quantum dot mass ratio at 1:4 were prepared and suspended in 200 μL H2O.", "A 50-μL portion of the zwitterionic magnetofluorescent nanoparticles was mixed with 7.2 μg EDC (37.5 nmole in PBS pH 7.4), 8.1 μg sulfo-NHS (37.5 nmole in PBS pH 7.4), 13.6 μL Neutravidin (1.13 nmole in H2O), and the total volume brought to 100 μL with PBS pH 7.4.The mixture was incubated for 2 hours at room temperature.", "After incubation, the magnetofluorescent nanoparticles were washed by centrifugation using PBS pH 7.4 (3×).", "The residue was dispersed in 200 μL PBS pH 7.4.Three μL of biotinylated magnetic microbeads (4.5 μm diameter, 4×108 beads/mL) were placed in each well of a microplate.", "Different volumes of the conjugate stock solution were loaded into wells, and PBS pH 7.4 buffer was used to bring the total volume in each well to 50 μL.", "The unconjugated zwitterionic quantum dot stock solution under the same dilutions was used as controls.", "The microplate was vortexed at room temperature for 1 hour, and then the magnetic microbeads in each well were washed using PBS pH 7.4 with 1% BSA and dispersed in 50 μL of PBS pH 7.4.The fluorescence signals of the suspended microbeads in wells were measured using a microplate reader at the excitation wavelength of 405 nm and the emission wavelength of 655 nm.", "The examples were performed in triplicates.", "Tumor Cell Targeting Using Peptide Conjugated Zwitterionic Magnetofluorescent Nanoparticles For cellular imaging studies, CTX was used as a targeting ligand.", "CTX is a 36-amino acid peptide that specifically binds to matrix metalloproteinase II (MMP-2) present on the surface of glioma cells with high affinity.", "The specific binding results in loss of gelatinase activity, disruption in chloride channel currents, reduction in both MMP-2 and chloride channel expressions, and internalization of chloride channels.", "U-87 is a human primary glioblastoma cell line expressing MMP-2 receptors, and CTX can specifically bind to and be internalized into U-87.To investigate whether CTX-conjugated zwitterionic magnetofluorescent nanoparticles can be specifically targeted to and internalized into U-87, a nonmalignant cell line human embryonic kidney 293 (HEK-293) was used as a control.", "FIGS.", "16A-16D present the representative overlaid confocal images demonstrating the cellular uptake/internalization when each type of cells were incubated with CTX- and non-conjugated zwitterionic magnetofluorescent nanoparticles under the same concentration of particles (i.e., 0.1 μg (Mn+Fe)/mL).", "Corresponding to each overlaid image in FIGS.", "16A-16D, FIG.", "17 shows the associated confocal images at different channels.", "FIG.", "16E shows fluorescence intensity per unit cytoplasm area (counting >200 cells) under a series of zwitterionic magnetofluorescent nanoparticle concentrations.", "It can be seen that U-87 cells do internalize more CTX-conjugated zwitterionic magnetofluorescent nanoparticles than HEK-293, and non-conjugated zwitterionic magnetofluorescent nanoparticles produce no significant cellular uptake by both cell lines.", "Through this comparison, it can be concluded that CTX-conjugated zwitterionic magnetofluorescent nanoparticles are specific to U-87.It was also observed that HEK-293 did internalize some CTX-conjugated zwitterionic magnetofluorescent nanoparticles at high concentrations.", "It is believed that the cellular uptake of CTX-conjugated micelles may involve pinocytosis mechanisms in high concentration ranges.", "In one example, zwitterionic magnetofluorescent nanoparticles were conjugated with CTX via EDC/sulfo-NHS mediated reaction.", "Briefly, 60 μL of the collected zwitterionic magnetofluorescent nanoparticles were reacted with 50 μg CTX with the assistance of EDC/sulfo-NHS in PBS for 2˜3 hours.", "The CTX-conjugated zwitterionic magnetofluorescent nanoparticles were washed using centrifuge, suspended in 250 μL PBS, and stored at 4° C. before use.", "A U-87 MG human brain glioblastoma cell line was cultured (37° C., 5% CO2) on glass coverslip coated with gelatin in MEM medium with 10% FBS until 50-80% confluency was achieved.", "The human embryonic kidney cell line HEK-293 was cultured (37° C., 5% CO2) on glass coverslip coated with PDL (poly-D-lysine) in RPMI-1640 medium with 10% FBS until 50˜80% confluency was achieved.", "For the zwitterionic magnetofluorescent nanoparticle tumor cell targeting examples, cells were incubated with CTX conjugated zwitterionic magnetofluorescent nanoparticle in DMEM with 2% BSA at various concentrations.", "As control, cells were also incubated with non-conjugated zwitterionic magnetofluorescent nanoparticles.", "After 2 hours of incubation, cells were gently rinsed three times with PBS, fixed with 4% PFA in PBS solution for 20 minutes and washed three times with PBS.", "For cellular nuclei staining, cells were incubated with DAPI, washed three times with PBS, and then mounted on glass slides.", "Cells were imaged using a Leica confocal microscope and images were analyzed using ImageJ.", "The statistical significance (p<0.05) was determined by the single-tailed student t test.", "Methods of Making Quantum Dots Using Thermal Decomposition Silver Acetate (99%), Indium (III) Acetate (99.99%), Zinc Stearate (ZnO: 12.5-14%), and Paraformaldehyde (97%) were purchased from Alfa Aesar.", "Sulfur (>99.99%), Trioctylphosphine (TOP, 90%), 1-Dodecanethiol (98%), 1-Octadecene (ODE, 90%), Oleic Acid (99%), Methanol (99.93%), and 1,10-Phenanthroline (99%) were purchased from Sigma Aldrich.", "Tetrahydrofuran (THF, >99%), Ethanol (>99%), Chloroform (>99.9%), and Hexane (95%) were purchased from Pharmco-AAPER.", "Methoxy poly(ethylene glycol)-b-poly(lactide-co-glycolide) (PEG-PLGA) (MW˜5000:5000 Da) and maleimide-PEG-PLGA (MW˜5000:5000 Da) were purchased from Akina, Inc. Dulbecco's Phosphate Buffered Saline (DPBS), Phosphate Buffered Saline (PBS), Ethylenediaminetetraacetic Acid (EDTA), Acetonitrile (99.96%) and Traut's Reagent were from Fisher Scientific.", "Heat-inactivated Fetal Bovine Serum (FBS) was from Gibco.", "U-87 MG and HEK-293 cells were ordered from the American Type Culture Collection (ATCC).", "RPMI-1640, MEM and DEMEM media were from Corning Cellgro.", "7-Aminoactinomycin D dye (7-AAD, excitation at 488 nm and emission at 647 nm) for cell nucleic acid staining was from Invitrogen.", "Chlorotoxin (CTX) was purchased from Alomone Labs.", "Bovine Serum Albumin (BSA) was from MP Biomedicals.", "Zeba spin desalting columns (MWCO 7k) were from Pierces.", "The ultraviolet and visible (UV-Vis) spectra of materials were obtained with a UV-Vis spectrometer (UV-2450 from Shimadzu).", "Photoluminescence spectra of quantum dots in organic-phase and aqueous-phase were acquired using a spectrophotometer (RF-5301PC from Shimadzu) Photoluminescence intensity of quantum dots in various buffers was obtained using a microplate reader (PerkinElmer 2030 equipped with a 535 nm emission filter and a 405 nm excitation filter).", "Transmission electron microscope (TEM) images and Energy-dispersive X-ray (EDX) spectra were acquired using a JEOL analytical transmission electron microscope (model JEM 2100F operated with a 200 kV acceleration voltage) equipped with an Oxford Energy-Dispersive X-ray (EDX) spectrometer.", "X-ray Diffraction (XRD) data was collected by a coupled Theta:2-Theta scan on a Rigaku Ultima-III diffractometer equipped with Copper X-ray tube with Ni beta filter, parafocusing optics, computer-controlled slits, and D/Tex Ultra 1D strip detector.", "The hydrodynamic sizes of micelles were measured using a dynamic light scattering (DLS) instrument (Malvern Zetasizer Nano ZS) equipped with a HeNe laser operating at 632.8 nm and a scattering detector at 173 degrees.", "Probe sonication was performed with a Misonix ultrasonic processor (QSonica S-4000) equipped with a microtip.", "Infrared (IR) spectra of materials were collected using a Fourier transform infrared (FT-IR) spectrometer (Perkin-Elmer Frontier) with Spectrum 10 software and the Universal ATR Sampling Accessory.", "Cells were imaged using a Leica confocal microscope and images were analyzed using ImageJ.", "Quantum yields of quantum dots were calculated according to the following equation, using standard references including Rhodamine 6G (emission peak at 556 nm, QY=95% in ethanol) and Oxazine 170 (emission peak at 640 nm, QY=63% in methanol), QYS=QYR×(IS/IR)×(AR/AS)×(nS/nR)2 where QYS and QYR are the quantum yields of sample and a standard reference, respectively; IS and IR are the integrations of fluorescence emissions of sample and a standard reference, respectively; AS and AR are the corresponding absorbance of sample and a standard reference, respectively; and nS and nR are the refractive indices of the corresponding solvents.", "During quantum yield measurements, the absorbance of each sample or each standard reference deviated by less than 0.1.For each sample, the standard reference with the most similar absorption and/or luminescence characteristics was chosen for quantum yield measurements.", "AIS/ZnS Quantum Dot Synthesis For a typical synthetic reaction, silver acetate (0.1 mmol), Indium (III) acetate (0.2 mmol), DDT (4 mL) and oleic acid (0.2 mmol, 63.5 μL) were added in a three-necked round bottom flask equipped with a condenser and magnetic stir bar.", "This mixture was degassed under vacuum for 20 minutes at 130° C. until the solution became clear.", "The solution temperature was then increased to 170° C. under a flow of Argon.", "As the temperature was increased, the color of the reaction solution changed gradually from yellow to orange, indicating the nucleation and growth of AIS quantum dots.", "Small amounts of the reaction solution (0.1-0.2 mL) were collected using a syringe at different time intervals and injected into hexane in clean vials to terminate growth of quantum dots.", "All solutions collected from the studies were diluted in a quartz cuvette with hexane for UV-Vis absorbance and photoluminescence measurements.", "After the reaction was complete, the solution was cooled to room temperature.", "The crude quantum dots solution was purified repeatedly with the solvent combinations of hexane/ethanol and chloroform/acetone by centrifugation and dried under vacuum.", "For ZnS shell growth, the Zn precursor was prepared by mixing zinc stearate (1.6 mmol) and ODE (4 mL) in a round-bottom flask.", "The mixture was gradually heated to ˜100° C. with stirring under vacuum until no vigorous bubbling was observed.", "The temperature was increased to 160° C. under argon until a clear solution was obtained.", "The sulfur precursor was prepared by dissolving sulfur (1.6 mmol) in DDT (3.2 mL) and TOP (0.8 mL).", "The ZnS shell coating of AIS quantum dots was carried out in situ without purification of the core.", "4 mL ODE was added to the crude AIS solution.", "This core solution was degassed under vacuum at 130° C. for 30 min and then to 210° C. under Argon.", "Both zinc and sulfur precursors were injected in sequence 5 times to the core growth solution at 210° C. in 0.5 mL portions at 15 min intervals.", "After reactions were complete, mixtures were cooled down to room temperature and AIS/ZnS quantum dots were purified using hexane/ethanol and chloroform/acetone, and dried under vacuum.", "It is possible to collect around 40 mg AIS quantum dots and around 100 mg AIS/ZnS quantum dots per reaction.", "FIG.", "18 shows photoluminescence spectra of AIS quantum dots during the time course of growth at 170° C. It can be seen that the quantum yield of AIS quantum dots is enhanced during growth reaching 13% at 75 min.", "The quantum yield enhancement over time is likely caused by a reduction of quantum dot core defects during heat treatment.", "Nevertheless, the photoluminescence spectral shift is not significant or sensitive to growth time.", "This optical characteristic suggests that AIS growth is very slow.", "The slow growth of AIS quantum dots is probably due to the relatively mild reaction temperature.", "When using a higher reaction temperature (230° C.), typically for CIS quantum dots, it was found that the products of the AIS synthetic system are hard to solubilize in chloroform and hexane, and thus hard to characterize optically.", "Characterization of Quantum Dots AIS quantum dots and AIS/ZnS quantum dots were further characterized using TEM.", "FIGS.", "19A and 19B present TEM and high resolution TEM (HRTEM) images of AIS and AIS/ZnS quantum dots, respectively.", "TEM images of CIS quantum dots made using thermal decomposition method embodiments disclosed herein are shown in FIGS.", "34A (normal resolution) and 34B (high resolution).", "The HRTEM images reveal crystalline patterns and sizes (˜4.5 nm for AIS and ˜6 nm for AIS/ZnS) of both quantum dots, indicating that the synthesized particles to be nanocrystals.", "Energy-dispersive X-ray (EDX) spectra confirm that AIS/ZnS quantum dots are composed of Ag, In, Zn, and S (FIG.", "19C) and AIS quantum dots are composed of Ag, In and S (FIG.", "20).", "More specifically, Table 1 shows the elemental atomic ratios of AIS and AIS/ZnS quantum dots.", "For AIS quantum dots, the atomic ratio between Ag and In is close to 1:1 with the atomic percentage of In slightly higher.", "For AIS/ZnS quantum dots, the atomic percentages of Ag and In drop off but the Ag percentage is reduced to a greater extent, and the atomic percentages of Zn and S are increased.", "The significant reduction of Ag atomic percentage in AIS/ZnS is probably due to Zn etching to replace Ag during the ZnS shell growth.", "It is generally agreed that cation exchange between Zn ions (from Zn precursor) with Ag (or Cu) in AIS (or CIS) causes photoluminescence blue shift and quantum yield enhancement.", "As shown in FIG.", "1, both effects were observed after growing ZnS shell on AIS cores.", "EDX analysis demonstrates a good match of the observed photoluminescence blue shift and quantum dot brightness enhancement of AIS/ZnS quantum dots compared to AIS quantum dots.", "The crystal phase of the AIS and AIS/ZnS quantum dots was examined by X-ray powder diffraction (XRD), as shown in FIG.", "21.The XRD pattern of AIS quantum dots shows three broad peaks at 2θ=26.8°, 44.6° and 52.2°, which can be assigned respectively to the diffractions of the (112), (204) and (312) planes of the tetragonal AgInS2.No other phases or impurities were observed.", "The AIS/ZnS quantum dots diffraction pattern shows a similar profile to that of the AIS quantum dots with three right-shifted peaks at 2θ of 27.7°, 46.0° and 54.0°.", "These peaks can be seen at positions intermediate between the diffractions of (112), (204), and (312) planes of tetragonal AgInS2 and the diffractions of (111), (220), and (311) planes of cubic ZnS, suggesting that Zn atoms were deposited on or diffused into the surface of the AIS cores.", "It should be noted that all characterized materials MS and AIS/ZnS quantum dots were synthesized with an original Ag:In precursor molar ratio of 1:2.This ratio can be used to avoid possible side products or black precipitates in reactions.", "AIS quantum dots were synthesized at different Ag:In precursor molar ratios (Ag:In=1:1, 1:2, and 1:4) without changing other conditions.", "The collected AIS samples were diluted in hexane and their photoluminescence and UV-Vis absorbance spectra were measured.", "As shown in FIG.", "22, all samples have similar photoluminescence spectra without obvious shifts.", "However, as illustrated in FIG.", "23, AIS quantum dots synthesized with Ag:In=1:1 have a wider absorbance wavelength range than the other two samples.", "Moreover, the AIS quantum dot solution (Ag:In=1:1) is a dark brown color, as illustrated in the inset of FIG.", "23.This suggests that there is something else (possibly Ag2S) produced during the reaction with Ag:In=1:1 at 170° C. but particles are not large enough to precipitate.", "The AIS quantum dot solution (Ag:In=1:1) was further used to grow the ZnS shell on AIS quantum dots and as shown in FIG.", "24A, the resultant product includes both a green solution and black precipitates.", "However, after the ZnS shell growth of AIS quantum dots (Ag:In=1:2), the resultants are clear (FIG.", "24B).", "These observations lead to the molar ratio of Ag:In=1:2 used in the synthesis.", "AIS synthesis using Ag:In=1:4 was not performed, because this ratio does not significantly shift quantum dot photoluminescence and excess In precursors in the reaction increase synthesis cost.", "In the proposed thermal decomposition approach, indium acetate and silver acetate could initially react with DDT to form intermediate compounds of Ag(SC12H25)x and In(SC12H25)x upon heating and are dissolved in DDT.", "As the reaction temperature is raised to 170° C., the intermediate compounds could act as precursors and further are decomposed into Ag—S and In—S to form Ag—In—S particles.", "Considering that there are some unexpected materials produced in the reaction with a molar ratio of Ag:In at 1:1, it is possible that Ag(SC12H25)x compounds are decomposed faster than In(SC12H25)x compounds and thus Ag—S are excess to form dark Ag2S particles.", "This could explain why 1:2 molar ratio of Ag:In is good for the reaction.", "Of note, the photostability of the produced AIS and AIS/ZnS quantum dots were tested and presented in FIGS.", "25A and 25B.", "It can be seen that AIS/ZnS quantum dots remain their photostability but AIS quantum dots are significantly photobleached.", "The photobleaching of AIS quantum dots could be caused by complex UV-induced chemical reactions at the interface between AIS and organic solvents.", "For example, electrons excited from AIS react with organic solvents to form free radicals which could further etch the AIS surface and quench the AIS photoluminescence.", "The photostability of AIS/ZnS quantum dots is believed to benefit from the protection of AIS core by its ZnS shell.", "To demonstrate potential biomedical applications of the produced AIS/ZnS quantum dots, these quantum dots were loaded into the core of PLGA-PEG based micelles to form quantum dot-micelles.", "The quantum dot-micelle preparation is schematically illustrated in FIG.", "26.Briefly, AIS/ZnS quantum dots were mixed with amphiphilic polymers of PLGA-PEG in organic solvents, and then dispersed them into water with sonication.", "During the vacuuming or water-replacement of organic solvents, the hydrophobic portion (PLGA) of the polymers and quantum dots are self-associated into a semi-solid core, and the hydrophilic portion (PEG) of the polymers forms a coronal layer.", "Photoluminescence spectra of AIS/ZnS quantum dots before and after water transfer via micelles were measured and are shown in FIG.", "27.It can be seen that the quantum dot-micelles show a slight red-shift in photoluminescence spectra and remain around 30% quantum yield compared to quantum dots suspended in organic solvents.", "The red-shift and the quantum yield drop after the phase transfer is believed to be caused by a compact quantum dot cluster in micelle cores.", "In the compact cluster, the emission photons from smaller quantum dots are absorbed by larger quantum dots to emit at longer wavelengths (a Förster resonance energy transfer process).", "Moreover, the cluster reduces the total excitation and emission surface area of quantum dots, resulting in a quantum yield drop.", "In spite of quenching, the quantum dot-micelles are still adequate for optical imaging applications.", "The insets of FIG.", "27 show the hydrodynamic sizes (126 nm±53 nm) of the quantum dot-loaded micelles measured by DLS and the TEM image of quantum dot-micelles, respectively.", "FIGS.", "28A and 28B show the TEM image and high resolution TEM image of an individual micelle.", "It can be seen that some dots are presented in a single micelle, and with further zooming into the micelle crystal lattices of dots are observed.", "Further EDS analysis on micelles (FIG.", "28C) shows that silver, indium, zinc and sulfur elements are presented in micelles, which are the composites of AIS/ZnS quantum dots.", "Preparation of AIS/ZnS Micelles The solution of 2.4 mg AIS/ZnS quantum dots and 9.6 mg PEG-PLGA (50% PEG-PLGA and 50% maleimide-PEG-PLGA) in THF/acetonitrile was layered on the top of cold water in a glass vial.", "The mixture was ultrasonicated using the Misonix Ultrasonic Liquid Processor with a 3 W output power for 1 minute.", "After sonication, THF/acetonitrile was removed by rotary evaporation at room temperature and the sample filtered through a 0.2 μm syringe filter to remove large aggregates.", "Empty micelles or single-nanoparticle based micelles were removed by centrifugation at 18,000 rpm for 15 minutes.", "The collected micelles were then re-filtered through a 0.2 μm syringe filter, concentrated using a centrifugal filter, dispersed in 400 μL of water, and stored at 4° C. until further use.", "Cell Culture, Cellular Uptake/Internalization of AIS/ZnS Micelles, and Cellular Imaging A U-87 MG human brain glioblastoma cell line (ATCC HTB-14) was maintained in Minimum Essential Media (MEM, Corning Cellgro) supplemented with 10% FBS at 37° C. and 5% CO2.The human embryonic kidney cell line HEK-293 (ATCC CRL-1537) was maintained in RPMI-1640 medium (Corning Cellgro) supplemented with 10% FBS at 37° C. and 5% CO2.For the quantum dot-micelle cellular uptake assay, U-87 and HEK-293 cells were plated on 24-well plastic plates and allowed to propagate for 2-3 days until they reached 50-80% confluency.", "The cells were incubated with CTX-conjugated or non-conjugated AIS/ZnS quantum dot-micelles in cell culture medium with 2% BSA for 2 hours at 37° C. After incubation, the solution was removed and the cells were washed three times with cold PBS buffer (pH 7.4).", "Then cells were fixed with 4% paraformaldehyde in PBS at room temperature for 20 minutes, followed by cell nucleus staining with 7-Aminoactinomycin D (7-AAD) for 45 minutes.", "The cells were examined by a laser scanning confocal microscope (LSCM, Leica, TCS SP8, Germany).", "The statistical significance (p<0.05) was determined by the single-tailed student t test.", "To demonstrate potential biomedical or biological applications of AIS/ZnS quantum dots, these quantum dots were loaded into the core of PLGA-PEG (5 kDa:5 kDa) based micelles to form the AIS/ZnS quantum dot-micelles and further investigated their specific-targeting functionality as cellular imaging probes or contrasts.", "With functional groups such as maleimide on PEG heads, the quantum dot-micelles were conjugated with chlorotoxin (CTX), a ligand that specifically binds to U-87 brain tumor cells.", "Cellular imaging studies showed that the quantum dot-micelles conjugated with CTX are specifically internalized into the brain tumor cells.", "Since the hydrophobic core of micelles can be loaded with both drugs and image contrasts, the specific cellular internalization suggests that the quantum dot-micelle structures could be important and versatile nanoplatforms for cell- or tissue-based diagnosis and therapy.", "Moreover, loading multiple quantum dots in the hydrophobic cores could avoid the blinking effect of single quantum dot and therefore facilitate continuous image tracking.", "Notably, the common surface modification approaches using thiolated ligands to exchange hydrophobic ligands capped on quantum dots (CdSe or CdS) are less favorable for AIS/ZnS quantum dots.", "This is because quantum dots, including AIS/ZnS quantum dots, are usually capped with the strong coordinating ligand dodecanethiol which is hard to displace by other foreign thiols.", "Although some groups have reported the use of amphiphilic polymers to encapsulate quantum dots (CdSe or CdS), they need an overnight air-dry process followed by a heated film hydration, or a 24-hour dialysis to remove organic solvents or excess amphiphilic polymers.", "The heated hydration or the prolonged dialysis may be incompatible with certain functional groups (e.g., maleimide) on polymers for bioconjugation.", "Moreover, these studies used cadmium-based quantum dots, which have been concerns for biomedical applications and environments.", "Loading cadmium-free AIS/ZnS quantum dots into PLGA-PEG based micelles for biomedical applications is simple and fast and effectively avoids these potential limitations.", "For CTX conjugation, the thiolation of CTX was completed by dispersing 12.5 nmol of CTX in 100 μL of PBS (pH8, 5 mM EDTA) with 125 nmol of Traut's reagent in 9 μL of PBS (pH 8, 5 mM EDTA) for 1 hour at room temperature.", "A volume of 87 μL of the prepared micelles in PBS (pH 6.7) was incubated with the thiolated CTX for 2-3 hours at room temperature.", "The resultant CTX-AIS/ZnS micelle product was purified using Zeba spin desalting columns (MWCO 7k) equilibrated with PBS, resuspended in 400 μL of PBS as a stock solution and stored at 4° C. before use.", "AIS/ZnS micelles without CTX conjugation were used as controls.", "For cellular imaging studies, CTX was used as a target ligand and used U-87 MG brain tumor cells as model cells.", "CTX is a 36-amino acid peptide that was originally isolated from scorpion venom, and specifically binds to tumors of neuroectodermal origin.", "Further studies have demonstrated that CTX is a specific matrix metalloproteinase II (MMP2) inhibitor and can bind with MMP2 present on the surface of glioma cells with high affinity.", "The specific binding results in loss of gelatinase activity, disruption in chloride channel currents, reduction in both MMP2 and chloride channel expressions, and internalization of chloride channels.", "Recent studies have also implicated annexin A2 (ANXA2) as a new recognition target of CTX in multiple tumor cell lines, which may activate similar uptake mechanisms as those of MMP2.U-87 is a human primary glioblastoma cell line expressing MMP2 receptors, and CTX can specifically bind to and be internalized into U-87.In this example, quantum dot-micelles were conjugated with CTX via a maleimide-thiol reaction.", "The CTX conjugation was confirmed by Fourier transform infrared spectroscopy, as shown in FIG.", "29.The spectrum of the AIS/ZnS quantum dot-micelles exhibits the characteristics of both the alkyl chains in oleic acid and dodecanethiol from AIS/ZnS quantum dots, corresponding to the CH2 stretching vibrations peaks at 2922 cm−1 and 2852 cm−1, and the ester carbonyl in PLGA from PLGA-PEG, corresponding to the C═O peaks at 1757 cm−1.After CTX conjugation with the quantum dot-micelles, a new peak at 1650 cm−1 corresponding to the N—H band of primary amines in lysine and arginine residues of CTX, appears in the spectrum of CTX-conjugated quantum dot-micelles.", "This appearance indicates the successful conjugation of CTX with the quantum dot-micelles.", "In order to verify that (i) CTX conjugated quantum dot-micelles can be internalized into U-87 cells and (ii) the internalization is due to the CTX-MMP2 interaction, two sets of examples were performed.", "In the first, U-87 cells were incubated with CTX conjugated quantum dot-micelles spiked in DEME with 2% BSA for 2 hours.", "In the second, 400 μM 1,10-phenanthroline was added to DEME, keeping all other conditions same.", "1,10-phenanthroline is a broad-spectrum MMP2 inhibitor and can disrupt the MMP2 activity by chelating and removing Zn ions from the catalytic domain of MMP2.As a result, 1,10-phenanthroline can block the interaction between CTX and MMP2 and thus the sequential cellular internalization process.", "After incubation, the U-87 cells from two sets of examples were washed, fixed, stained and imaged.", "Representative confocal images shown in FIG.", "30A demonstrates the cellular uptake/internalization of CTX-conjugated quantum dot-micelles by U-87 cells.", "The representative confocal images in FIG.", "30B illustrate the quenching effect of 1,10-phenanthroline on uptake/internalization.", "FIG.", "30C shows quantitative data (the fluorescence intensity from the internalized quantum dot-micelles per unit cytoplasm area counting >200 cells) comparing cellular uptake/internalization and the quenching effect under the different concentrations or dilutions of CTX-conjugated quantum dot-micelles (100-800 times dilution).", "These results demonstrate that the internalization of CTX-conjugated quantum dot-micelles into U-87 cells is caused by an interaction between CTX and MMP2.To further confirm that CTX-conjugated quantum dot-micelles is specific to U-87, human embryonic kidney 293 cells (HEK-293), a nonmalignant cell line that does not express MMP2 and ANXA2 on cell surfaces, was used as controls to examine their response to quantum dot-micelles conjugated with/without CTX and compared to those of U-87.FIGS.", "31A and 31B and FIGS.", "31C and 31D show the representative cellular uptake images (overlaid confocal images) for U-87 and HEK-293, respectively, under the same quantum dot-micelle concentration or dilution.", "FIG.", "31E shows fluorescence intensity (from the internalized quantum dot-micelles) per unit cytoplasm area under a series of dilutions of quantum dot-micelles stock solutions.", "It can be seen that U-87 cells do internalize more CTX-conjugated quantum dot-micelles (FIG.", "31E, left-most bar of each bar group) than HEK-293 (FIG.", "31E, third bar from the left for each bar group), and non-conjugated quantum dot-micelles (FIG.", "31E, second and fourth bars from the left for each bar group) produce no significant cellular uptake by both cell lines.", "Through this comparison, it can be concluded that CTX-conjugated quantum dot-micelles are specific to U-87.Interestingly, it was also observed that HEK-293 did internalize some CTX-conjugated quantum dot-micelles at a high concentration.", "Some pioneer work has reported that CTX can increase the rate of pinocytic internalization.", "The cellular uptake of CTX-conjugated micelles may involve pinocytosis mechanisms in high concentration ranges.", "Using PLGA-PEG to wrap AIS/ZnS quantum dots is an effective approach for phase transfer and bio-applications.", "The AIS/ZnS quantum dot-micelles can be used as image contrasts or probes can be used to detect endogenous targets expressed on brain tumor cells, or more broadly to cell- or tissue-based diagnosis and therapy.", "Similar quantum dot-micelles also can be constructed using the zwitterionic polymeric coatings described herein.", "Synthesis of Cu:AIS Quantum Dots Ag(DDTC) (0.1 mmol), In(Ac)3 (0.2 mmol) and DDT (4 mL) were added in a three-necked round bottom flask equipped with a condenser and magnetic stir bar.", "This mixture was degassed under vacuum for 30 min at 125° C. until the solution became clear.", "The solution temperature was then increased to 190˜200° C. under a flow of argon and held at this temperature for 10 min to grow AIS cores.", "After the reaction was completed, the solution was cooled to room temperature, and 4 mL of ODE was added to the AIS core growth solution without any purification.", "Then the solution was heated to 120° C. under vacuum for 20 min and then to 190˜200° C. under argon.", "Copper precursors prepared by dissolving CuI (0.2 mmol) in DDT (8 mL) were injected into the solution for the formation of Cu:AIS quantum dots.", "After 10 min growth, the solution was cooled to room temperature.", "The nanocrystal solution was purified repeatedly with the solvent combinations of hexane/ethanol and chloroform/acetone by centrifugation and then dried under vacuum.", "For the synthesis of Cu:AIS quantum dots with different Cu doping concentrations, the Cu initial concentrations ([Cu]/([Ag]+[In])) were changed in the range from 0˜10 mol %.", "Small amounts of the reaction solution (0.1˜0.2 mL) were collected using a syringe at different time intervals and injected into hexane in clean vials to terminate growth of quantum dots.", "All solutions collected from the example were diluted in a quartz cuvette with hexane for UV-Vis absorbance and photoluminescence measurements.", "Synthesis of Cu:AIS/ZnS Quantum Dots For ZnS shell growth, the zinc precursor was prepared by dissolving zinc stearate (0.4 mmol) in ODE (4 mL) at 140° C., and the sulfur precursor was prepared by dissolving sulfur (0.4 mmol) in DDT (3.2 mL) and TOP (0.8 mL).", "The growth of the ZnS shell on Cu:AIS quantum dots was conducted in situ without purification of the core solution.", "Once the growth of cores was completed, the nanocrystal solution was heated up to 210° C. under argon.", "Then both zinc and sulfur precursors were injected in sequence 3 times to the Cu:AIS growth solution in 0.5 mL portions at 15 min intervals.", "After the reaction was finished, mixtures were cooled down to room temperature and Cu:AIS/ZnS quantum dots were purified using hexane/ethanol and chloroform/acetone, and dried under vacuum.", "Quantum yields of quantum dots were calculated according to the following equation, using standard references including Rhodamine 6G (emission peak at 556 nm, QY=95% in ethanol) and Oxazine 170 (emission peak at 640 nm, QY=63% in methanol), QYS=QYR×(IS/IR)×(AR/AS)×(nS/nR)2 where QYS and QYR are the quantum yields of sample and a standard reference, respectively; IS and IR are the integrations of fluorescence emissions of sample and a standard reference, respectively; AS and AR are the corresponding absorbance of sample and a standard reference, respectively; and nS and nR are the refractive indices of the corresponding solvents.", "In quantum yield measurements, the absorbance of each sample or each standard reference deviated by less than 0.1.For each sample, the standard reference with the most similar absorption and/or luminescence characteristics was chosen for quantum yield measurements.", "Amphiphile-Encapsulated Cu:AIS/ZnS Composite Probes for Cellular Imaging 6.67% Cu:AIS/ZnS quantum dots were encapsulated using zwitterionic polymeric coatings using methods disclosed above.", "2.4 mg Cu:AgInS2/ZnS quantum dots in THF (900 μL) and 1.6 mg zwitterionic amphiphiles in CHCl3-MeOH (64 μL) were dispersed into water under sonication.", "After sonication, the organic solvents were removed by rotary evaporation at room temperature and the sample was filtered through a 0.2 μm syringe filter.", "Empty micelles or single-nanoparticle based micelles were removed by centrifugation at 18 000 rpm for 25 min.", "The collected micelles were dispersed in 400 μL of water as the micelle stock.", "60 μL of the micelle stock was reacted with 0.3 mg RGD in borate buffer for 2˜3 hours after the activation of carboxyl groups on micelles' surface using EDC/Sulfo-NHS.", "The RGD-conjugated micelles were washed by centrifugation, suspended in 200 μL borate, and stored at 4° C. before use as the conjugate stock.", "The same reaction was done for the conjugation of micelles with RAD peptide, and the RAD-conjugated micelles were used as a negative control.", "Non-conjugated micelles were also used as a control.", "A U-87 MG human brain glioblastoma cell line was cultured (37° C., 5% CO2) on glass coverslips coated with gelatin in MEM medium with 10% FBS until 50˜80% confluency was achieved.", "The human embryonic kidney cell line HEK-293 was cultured (37° C., 5% CO2) on glass coverslips coated with PDL (poly-D-lysine) in RPMI-1640 medium with 10% FBS until 50˜80% confluency was achieved.", "For the specific cell targeting examples, cells were incubated with RGD-conjugated micelles in DMEM with 2% BSA at various concentrations or dilutions.", "As controls, cells were also incubated with RAD-conjugated micelles and non-conjugated micelles.", "After 3 h incubation, cells were gently rinsed three times with PBS, fixed with 4% PFA in PBS solution for 20 minutes and washed three times with PBS.", "For cellular nuclei staining, cells were incubated with DAPI, washed three times with PBS, and then mounted on glass slides.", "Cells were imaged using a confocal microscope.", "Two-way ANOVA was applied to detect the differences among two cell lines.", "SAS (Statistical Analysis Software) 9.4 was used for data analysis.", "Cu atoms were doped into AIS composites through a surface doping strategy—AIS quantum dots were first grown via thermal decomposition and then Cu precursors were injected into the AIS NC solution to react with AIS quantum dots.", "FIG.", "35A presents the effect of Cu concentrations on the photoluminescence spectra of Cu doped AIS quantum dots (Cu:AIS quantum dots).", "It can be seen that the photoluminescence peak wavelength shows a continuous red shift from around 600 to 660 nm as Cu concentration in reaction is increased from 0 to 6.67% (molar percentage), and the red shift is not significant for Cu concentration above 6.67% or at 10%.", "The corresponding UV-vis absorption spectra of these Cu:AIS quantum dots are shown in FIG.", "35B As the Cu concentration increases, the absorbance edges of these samples are monotonously shifted to longer wavelength.", "The absorption edge of 10% Cu:AIS is similar to that of 6.67% Cu:AIS.", "This observation is consistent with their photoluminescence spectra.", "In FIG.", "35A it can also be seen that quantum yields of Cu:AIS quantum dots decrease from around 30% to 20% with the increase of Cu concentrations from 0% to 6.67%.", "Quantum yield of 10% Cu:AIS quantum dots even decrease further even though the photoluminescence is not red shifted.", "Through further comparing the photoluminescence spectra of Cu:AIS quantum dots, it can be seen that their shapes are also affected by Cu concentrations.", "The shape dependence on Cu concentration implicates that Cu atoms are incorporated into NC lattices and cause some changes of the lattice energy band or contribute to NC photoluminescence mechanisms.", "Of note, as shown in the inset of FIG.", "35A the photoluminescence of non-doped or pure AIS quantum dots prepared in the thermal decomposition is hard to be tuned by the NC growth time.", "It can be seen that Cu doping is an effective way to tune nanocrystal photoluminescence.", "The reason to adopt surface doping is that the optical property of quantum dots is more controllable than that using homogenous doping.", "With 3.33% Cu:AIS quantum dots as a demonstration, FIG.", "36A shows the evolution of their photoluminescence spectra in the time course of reaction through surface doping.", "It can be seen that around 45 nm red-shift occurs at 5 min after Cu injection.", "With further prolonged reaction time, no remarkable change in photoluminescence is observed with respect to peak wavelength and quantum yield.", "The similar observation is also noticed in their absorption spectra as shown in FIG.", "36B This demonstrates that the Cu doping of AIS quantum dots is a fast and reliable process.", "However, with the same starting materials, if Cu precursor is mixed with silver and indium precursors in DDT for thermal decomposition, the photoluminescence of the produced quantum dots is observed to red shift to around 650 nm and then blue shift to around 600 nm, as shown in the inset of FIG.", "36A.", "Moreover, the photoluminescence spectra become broader in the time course of reaction.", "It is possible that the final products could have both sub-populations of doped AIS quantum dots and non-doped (or intrinsic) AIS quantum dots.", "Clearly, surface doping is a better approach to control the NC optical property.", "To further understand the optical property of Cu:AIS quantum dots, these quantum dots were first characterized using XRD, TEM and EDX.", "Three representative samples (pure AIS, 1.67% Cu:AIS and 6.67% Cu:AIS) were investigated.", "As shown in FIG.", "37A, the XRD pattern of the pure AIS quantum dots can be indexed with a tetragonal AgInS2 crystal.", "Three apparent diffraction peaks observed at 20=26.8, 44.7, and 52.6° can be assigned to diffractions from the (112), (204) and (312) planes of the tetragonal phase.", "Compared to the pure AIS quantum dots, diffraction patterns of Cu:AIS quantum dots slightly shifts to the higher angle side and approaches the 20 values of the tetragonal CuInS2 (CIS) along with the increase of Cu concentration.", "Since the ionic radius of Cu (0.74 nm) is smaller than that of Ag (1.14 nm), the observed shifts of the XRD patterns indicate the gradual replacement of Ag with Cu to form Cu:AIS quantum dots instead of forming individual CIS quantum dots.", "These three samples were further characterized using TEM.", "FIG.", "37B-37D present their TEM and high-resolution TEM (HRTEM) images.", "TEM images of AIS and Cu:AIS quantum dots show that their sizes are at 4˜5 nm, indicating that the incorporation of Cu does not significantly influence the particle size.", "The HRTEM images show lattice plane spacings of 0.342, 0.340, and 0.332 nm for AIS, 1.67% Cu:AIS, and 6.67% Cu:AIS quantum dots, respectively.", "The values of these spacings are corresponding to (112) planes determined from diffraction peaks at around 26-28° of XRD patterns in FIG.", "37A.", "Both HRTEM and XRD data reveal that the obtained Cu:AIS quantum dots are not a mixture of individual AIS and CIS phases, but a Cu:AIS crystal.", "The energy dispersive X-ray (EDX) spectra further confirms that AIS quantum dots are composed of Ag, In, and S and Cu:AIS quantum dots are composed of Cu, Ag, In and S. The resultant elemental compositions of AIS and Cu:AIS quantum dots are summarized in Table 1.For pure AIS quantum dots, the atomic ratio between Ag and In is close to 1:1.For Cu:AIS quantum dots, as Cu concentration is increased in the reaction, more Cu atoms are doped into quantum dots but the atomic percentage of Ag decreases.", "This observation indicates that Cu atoms enter the AIS structure and partially replace Ag atoms.", "The reason for the preferential substitution of Ag instead of In probably is that the Ag—S bond is weaker than the In—S bond.", "More Cu atoms doped into quantum dots could cause more structure or surface defects quenching the NC photoluminescence for lower quantum yields.", "The EDX analysis of 10% Cu:AIS quantum dots was also conducted and the result shows that the element atomic ratio of Cu:Ag:In:S is 5.1:16.4:27.3:51.2.Compared to the element atomic ratio for 6.67% Cu:AIS quantum dots (as shown Table 1), more Cu atoms are observed in 10% Cu:AIS quantum dots.", "It is possible that the Cu level in AIS quantum dots may get saturated for 6.67% Cu:AIS quantum dots, and thus with a higher Cu concentration in doping, additional Cu atoms may be absorbed on NC surface to quench photoluminescence but not affect the position of photoluminescence peak.", "To enhance the photoluminescence quantum yield, AIS and Cu:AIS quantum dots were passivated with a shell of ZnS to form AIS/ZnS and Cu:AIS/ZnS quantum dots.", "The quantum yields of AIS/ZnS, 1.67% Cu:AIS/ZnS and 6.67% Cu:AIS quantum dots are around 52.6%, 52.6%, 56.5% quantum yields, respectively.", "All of them present 30˜50 nm blue shift in their photoluminescence spectra after ZnS coating.", "FIG.", "38A shows digital photographs of Cu:AIS and Cu:AIS/ZnS quantum dots suspended in organic solvents under a UV lamp.", "It can be seen that the emission colors of cores and core/shell structures are Cu-concentration dependent.", "FIG.", "38B demonstrates the typical photoluminescence and absorption spectra of 6.67% Cu:AIS quantum dots before and after ZnS coating.", "FIG.", "38C shows that the XRD diffraction pattern of the 6.67% Cu:AIS/ZnS quantum dots has a similar profile to that of 6.67% Cu:AIS cores, and shows a medium phase of Cu:AIS and ZnS crystals.", "The three main peaks shift to the high angle side and locate in the middle position of the pattern of Cu:AIS quantum dots and the standard pattern of cubic ZnS, which further suggests that Zn atoms are deposited or diffused to the surface of the Cu:AIS cores.", "FIG.", "38D shows the corresponding TEM and HRTEM images.", "The HRTEM image also reveals that the quantum dots have a clear lattice fringe with a plane spacing of 0.310 nm.", "The lattice planet spacing is close to that of the (111) plane in cubic ZnS quantum dots.", "Similar to the core samples, Cu:AIS/ZnS quantum dots have a size around 4˜5 nm.", "Probably, the ZnS coating is mainly dominated by zinc etching into core quantum dots.", "As confirmed by the EDX spectrum of 6.67% Cu:AIS/ZnS quantum dots, the elemental composition ratios of Cu, Ag, In, Zn, and S obtained from EDX analysis were 2.1%, 9.5%, 19.8%, 12.7%, and 55.8%, respectively.", "Both the atomic percentages of Ag and In decrease, however, the amount of Ag is reduced to a greater extent.", "At the same time, the atomic percentage of Zn is increased.", "The more reduction of Ag atomic percentage in Cu:AIS/ZnS quantum dots is probably due to Zn etching to preferentially replace Ag during the ZnS shell growth.", "The Cu concentration in the core/shell structures was observed to be is slightly lower than that of the Cu:AIS cores.", "Such results suggest that in the Cu doping process, a portion of Cu atoms may sit on the surface of AIS cores and be replaced by zinc atoms during ZnS coating or zinc etching, and another portion of Cu atoms may diffuse into an inner layer of AIS lattice which cannot be replaced by zinc but still affect the photoluminescence of core/shell quantum dots.", "FIG.", "39A shows the decay curves for AIS, 1.67% Cu:AIS, and 6.67% Cu:AIS quantum dots.", "FIG.", "39B presents the decay curves for their corresponding core/shell structures.", "For each decay curve, a biexponential function (l(t)=A1e−t/τ1+A2e−t/τ2) was used to fit the curve.", "τ1 and τ2 are the short and long lifetime parameters, respectively.", "A1 and A2 are the amplitudes of the decay components at t=0.Table 2 lists the extracted characteristics parameters (τ1, τ2, A1, and A2) for all investigated samples.", "According to literature, the photoluminescence lifetime parameters of AIS quantum dots could be associated with different electron-hole recombination pathways or mechanisms.", "After light excitation, electrons will be relaxed from conduction bands to surface trap states and donor states.", "The short lifetime is be attributed to electron transition from surface trap states (caused by surface defects) to valence bands.", "The long lifetime is attributed to electron transition from donor states to acceptor states, which results in the broad emission peaks of AIS quantum dots.", "From Table 2, it is observed that upon comparing A1 parameter for each core and its corresponding core/shell structure, A1 parameter is decreased and τ1 is increased after ZnS shell growth.", "Considering the ZnS shell growth on each core causes quantum yield enhancement, it is reasonable to attribute the decrease of A1 to the minimization of surface defects.", "The prolonged τ1 of core/shell structures probably is associated with electron transition from near-surface trap states or deep trap states to valence bands.", "The near-surface trap states or deep trap states could be closer to the donor states in energy levels and thus have a relatively longer lifetime for electrons.", "Upon examining the effect of Cu concentrations on A1 and τ1 of AIS cores, it can be seen that A1 of Cu:AIS cores is decreased compared to that of non-doped AIS cores.", "According to the literature model, the A1 decrease should implicate the minimization of surface defects and thus the enhancement of quantum yield upon Cu doping.", "However, FIG.", "35A show that Cu doping causes the decrease of quantum yields.", "Moreover, as shown in FIG.", "35A with low Cu concentrations, a shoulder in the photoluminescence spectrum is presented at the right side of the main photoluminescence peak.", "As Cu concentration increases, the shoulder is shifted to the left side of the main photoluminescence peak.", "As shown in Table 2, Cu doping also prolongs the average photoluminescence lifetime of quantum dots.", "It seems that although the literature model can well explain the effect of ZnS coating as well as some phenomena of non-doped or intrinsic AIS quantum dots, a more sophisticated model or a different viewpoint is needed to explain the photoluminescence mechanisms of Cu:AIS quantum dots as well as the reason for the prolonged average photoluminescence lifetime upon Cu doping.", "According to literature, the decrease of quantum yields with the increase of Cu doping levels is probably due to two reasons: (i) more defects in Cu:AIS lattice are created; (ii) high doping concentration causes closer distance between Cu atoms and cause strong Cu—Cu interaction and photoluminescence quenching.", "The transition/change of the photoluminescence spectrum shape versus Cu concentration in doping may be caused by multiple electron-hole recombination paths.", "According to literature, Cu doping could introduce additional Cu T2 states in the bandgap of AIS quantum dots.", "Meanwhile, our material characterization shows that Cu can etch and replace Ag in AIS host quantum dots, and the doped Cu could form a Cu—In—S(CIS) layer on AIS surface.", "The formed CIS layer could possess some nature of CIS bandgap, and new donor-acceptor pairs from CIS structures could be existing.", "The new CIS donor-acceptor pairs also are energy levels incorporated in the bandgap of AIS hosts.", "On the other hand, AIS also has its own donor-acceptor pairs.", "As a result, there could be several electron-hole recombination paths.", "The photoluminescence of quantum dots should be a synergistic effect of all these recombination paths.", "Cu T2 states and/or new CIS donor-acceptor pairs are Cu-concentration dependent, and thus gradually they can be more dominant than AIS donor-acceptor pairs as the Cu concentration increases in the doping process.", "As a result, the change of the photoluminescence spectrum shape versus Cu concentration can be observed.", "With respect to the prolonged average photoluminescence lifetime, due to the incorporation of Cu T2 states, the excited-state lifetime of the dopant emission is longer than the excitonic emission and the surface emission.", "Thus, Cu doped quantum dots gain a prolonged photoluminescence lifetime.", "The new CIS donor-acceptor pairs also are energy levels in the AIS bandgap and they could function as Cu T2 states to prolong the average photoluminescence lifetime.", "Of note, these T2 states and/or new CIS donor-acceptor pairs should be the causes for the emission at longer wavelengths (or red-shift in the doping process).", "Through this measurement on photoluminescence decay, it is also good to know that the average photoluminescence lifetime of the produced quantum dots is in the range of 300˜500 ns.", "The quantum dots with long lifetimes are attractive for bioimaging—as bioimaging probes, they can be scanned using microscopy not only in regular intensity-based fluorescence mode but also in time-resolved fluorescence mode.", "Specifically, in the time-resolved mode, the long lifetime can distinguish NC fluorescence signals from the fast decaying autofluorescence in cells/tissue, and ensure quantum dots for more sensitive imaging.", "TABLE 2 Nanocrystals τ1/ns A1 τ2/ns A2 τavg/ns AIS 49 51.6% 369 48.4% 329 1.67% Cu:AIS 62 45.2% 413 54.8% 374 6.67% Cu:AIS 66 44.8% 414 55.2% 374 AIS/ZnS 125 49.2% 416 50.8% 350 1.67% Cu:AIS/ZnS 131 41.7% 461 58.3% 405 6.67% Cu:AIS/ZnS 151 42.2% 499 57.8% 436 To demonstrate potential biomedical applications of Cu:AIS/ZnS quantum dots (i.e., specific targeting to brain tumor cells), composites with 6.67% Cu:AIS/ZnS quantum dots and a zwitterionic polymer coating were formed through self-assembling.", "Human primary glioblastoma U-87 MG cells and human embryonic kidney 293 cells (HEK-293) are cell lines used in this example.", "The cytotoxicity of the micelles was first studied using these two cell lines.", "Cells were incubated with micelles in growth medium with 10% FBS at various concentrations for 48 hours at 37° C. After incubation, the growth medium was removed and the cells released from well bottom using stempro accutase, and then stained with FDA/PI to determine live vs dead cells using flow cytometry (Dead cells are red staining by PI and live cells are green staining by FDA).", "The cell viability was calculated as the ratio of live cells over the sum of live cells and dead cells.", "FIG.", "40 shows the measured cell viabilities for U-87 MG (right-most bar for each bar group) and HEK-293 (left-most bar for each bar group) after 48-hour incubation with micelles under different concentrations.", "It can be seen that for each cell line, the cell viabilities under all different micelle concentrations are around 95%, which are comparable to that of controls (no micelles in incubation).", "Thus the micelles loaded with Cu:AIS quantum dots are biocompatible.", "On the basis of the cytotoxicity example, these micelles were further conjugated with RGD and RAD peptides via EDC/Sulfo-NHS mediated reaction.", "RGD can specifically target to integrin αvβ3 overexpressed on U-87 MG cells and thus it is specific to U-87 MG cells.", "RAD with a molecular structure similar to RGD but is nonspecific to U-87 MG cells and thus used as a control.", "HEK-293 not expressing integrin αvβ3 is used as a cell line control.", "In cellular uptake studies, each cell line was incubated with the RGD-conjugated micelles, RAD-conjugated micelles, and non-conjugated micelles under difference concentrations or dilutions in MEM medium with 2% BSA for 3 hours at 37° C. After incubation, cells were gently rinsed three times with PBS, fixed with 4% PFA in PBS solution for 20 minutes and washed three times with PBS.", "Afterwards, cells were incubated with DAPI for cellular nuclei staining, washed three times with PBS, and then mounted on glass slides.", "The mounted cells were then imaged using a Leica confocal microscope and images were analyzed using ImageJ.", "FIGS.", "41A-41F shows representative cellular uptake images (overlaid confocal images) for U-87 and HEK-293.Quantitative data counting >100 cells for each experimental condition were presented in FIG.", "42.It can be seen that for each micelle concentration or dilution, U-87 cells internalize more RGD-conjugated micelles (FIG.", "42, third bar from the left for each bar group) than HEK-293 (FIG.", "42, sixth bar from the left for each bar group).", "RAD-conjugated (FIG.", "42, second and fifth bars from the left for each bar group) and non-conjugated micelles (FIG.", "42, left-most and fourth bars from the left for each bar group) had no significant cellular uptake by any of cell lines.", "Clearly, the micelles using Cu:AIS/ZnS quantum dots can be applied to the detection of endogenous targets expressed on brain tumor cells.", "In this embodiment, the micelles were scanned in regular intensity-based fluorescence mode.", "Scanning also could be conducted in time-resolved fluorescence mode to achieve better image quality with respect to signal/noise ratio.", "In addition, radioactive Cu may be doped into AIS quantum dots so that the achieved quantum dots have dual imaging functionalities for positron emission tomography (PET) and luminescence imaging.", "Considering the hydrophobic core of micelles can also be loaded with both drugs and image contrasts, the specific cellular internalization suggests that the cadmium-free Cu:AIS/ZnS-micelles may also load drugs to be versatile nanoplatforms for cell- or tissue-based diagnosis and therapy.", "Effect of Chloride Surface Passivation on AgInS2 (AIS) QDs In these examples, AIS quantum dots re synthesized using In(Ac)3 and then are mixed with InCl3 solution at 130° C. (InCl3 dissolved in a mixture of oleic acid and 1-octadecene).", "The controls used as comparisons can be synthesized using In(Ac)3 and then mixing with In(Cl)3 solution at 130° C. ((In(Ac)3 dissolved in a mixture of oleic acid and 1-octadecene).", "At 130° C., such a temperature will not trigger any reactions but promote the diffusion of chloride to quantum dot surfaces.", "In some examples, AIS QDs were synthesized using silver nitrate (0.1 mmol), In(Ac)3 (0.2 mmol), 1-DDT (8 mL) and oleic acid (250 μL) at 175° C. Then, the quantum dot solution was cooled down from 175° C. and maintained at 130° C. under an Ar flow.", "0.1 mmol InCl3 or In(Ac)3 was dissolved in a mixture of oleic acid and 1-octadecene at 130° C. 2.5 mL of InCl3 or In(Ac)3 solution was injected into the quantum dot solution for 60 min stirring.", "The quantum dot solutions were sampled for quantum yield measurements before and after the injection of InCl3 or In(Ac)3 solution.", "The data are illustrated graphically in FIGS.", "44A and 44B, wherein FIG.", "44A shows that with chloride treatment, the quantum dots reach around 40% enhancement, and FIG.", "44B shows that without chloride treatment, the quantum yield of the quantum dots remains unchanged.", "Synthesis of Mn-Doped AIZS/ZnS Composites Ag(DDTC) (0.1 mmol), In(Ac)3 (0.2 mmol) and DDT (4 mL) were added into a 50 mL three-necked round bottom flask equipped with a condenser and a magnetic stir bar.", "The mixture was heated to 125° C. under vacuum until a clear solution was obtained, and to 200° C. under a flow of argon for 10 minute reaction.", "Then, 0.5 mL of Zn precursors (0.4 mmol zinc stearate in 4 mL of ODE) was added drop-wise into the AIS core solution to form AIZS nanocrystals.", "Afterwards, 0.25, 0.75 or 1.25 mL of Mn precursors, which were prepared by dissolving 0.1 mmol Mn(Ac)2 in the mixture of 0.75 mL of ODE and 0.25 mL of OAm, were added drop-wise into the AIZS nanocrystal solution and the solution was maintained at 240° C. for 15 minutes.", "Subsequently, for the ZnS shell coating or nanocrystal surface etching by zinc, 2 mL of Zn precursors were slowly added drop-wise to the Mn-doped AIZS growth solution (cooled to 200° C.) and the solution was then maintained at 200° C. After the reaction was complete, the mixture was cooled down to room temperature.", "The Mn:AIZS/ZnS nanocrystals were purified repeatedly with the solvent combinations of hexane/ethanol and chloroform/acetone by centrifugation and then dried under vacuum.", "Undoped AIZS/ZnS nanocrystals were prepared in the way as described above but without any addition of Mn precursors.", "Results obtained from this example are shown in FIGS.", "45A-45C, 46, 47A-47D, and 48.Thermal stability study was performed on these Mn-doped ternary nanocrystals.", "A small amount of 0.075 mmol-Mn-doped AIZS/ZnS nanocrystals were dissolved in ODE and DDT (DDT is a native ligand coated on nanocrystals during synthesis, and it is thus here used as surfactant for nanocrystals).", "After vacuum and nitrogen filling, the solution was heated from room temperature (RT) to 170° C. and then back to room temperature.", "In this example, temperatures higher than 170° C. were avoided to avoid thermal decomposition of DDT.", "As shown in FIG.", "49, after 50° C., the photoluminescence of the solution apparently fades with a slight blue-shift (towards yellow emission) in the time course of the temperature rising to 170° C. The photoluminescence (intensity and wavelength) of the solution recovers as the temperature is back to RT.", "This is a reversible photoluminescence quenching.", "Other two types of Mn:AIZS/ZnS nanocrystals were also tested and presented the similar behavior to that of 0.075 mmol-Mn:AIZS/ZnS nanocrystals.", "The results are illustrated in FIG.", "49.In another example, Mn-doped AZIS nanocrystals (schematically illustrated in FIG.", "50A) were prepared using 0.2 mmol Zn precursor, 0.2 mmol In precursor, 0.025 mmol Mn precursor, 0.8 mmol sulfur precursor, and Ag precursor in the range of 0.025˜0.1 mmol.", "After Mn atoms were doped into AZIS nanocrystals, a Zn precursor and sulfur precursor were added into the reaction flask to grow a ZnS shell on nanocrystals to form Mn-doped AZIS/ZnS nanocrystals.", "As references, AZIS/ZnS nanocrystals using the exact same conditions above but without any Mn precursors in synthesis were made.", "Results from analyzing nanocrystals formed in this example are shown in FIGS.", "50B and 50C.", "In this example, a composite comprising I(II)-III-VI nanocrystals was made having a composite structure similar to that illustrated schematically in FIG.", "51A (though a person of ordinary skill in the art with the benefit of this disclosure recognizes that the synthesized composite may have more or fewer zwitterionic ligands that the four illustrated in FIG.", "51A).", "The solution of 0.6 mg MnFe2O4 magnetic nanoparticles and 2.4 mg I(II)-III-VI nanocrystals in THF (900 μL) and 1.7 mg PMAO-CBSB in CHCl3-MeOH (˜50 μL) was layered on top of cold water in a glass vial.", "The mixture was ultrasonicated using the Misonix Ultrasonic Liquid Processor with a 5 W output power for 1 minute.", "After sonication, the organic solvents were removed by rotary evaporation at room temperature and the sample filtered through a 0.2 μm syringe filter.", "Empty micelles or single-nanoparticle based micelles were removed by centrifugation at 18,000 rpm for 25 min (twice).", "The collected ZW-MFNP conjugates were dispersed in 400 μL of water, and stored at 4° C. until further use.", "Representative magnetic resonance image and optical images obtained from such composites at difference concentrations are provided by FIG.", "51B.", "In another example, composites were further coupled with chlorotoxin.", "As shown by FIG.", "52, such conjugated composites are biocompatible with different cell lines (e.g., U87, HEK293, and activated THP1).", "In another example, U87 cells were co-incubated with chlorotoxin-conjugated conjugates (7.2 mg NC/mL) and 1 mM LysoTracker (ex465/em535, a fluorescent marker from Invitrogen for secondary endosomes or lysosomes) for 3 hours and 24 hours, respectively.", "Afterward, U87 cells were fixed and stained with DPAI, and then scanned using confocal microscopy.", "Representative overlay images for 3 and 24 hr incubation times are shown in FIGS.", "53A and 53B, respectively.", "Spot provided by these images represent micelles (smaller peripheral spots relative to the large spots), endosomes/lysosomes (smaller peripheral spots relative to the large spots) and nuclei (large spots).", "Also indicated in FIGS.", "53A and 53B is the co-localization of micelles with endosomes/lysosomes.", "Such co-localization is qualitative, and it is affected by the intensity the different peripheral spots in these images.", "Mander's and Costes's methods, which are implemented in ImageJ as Plugin Coloc2, were used for colocalization analysis.", "These approaches are not affected by the intensity difference of two colors or probes, and automatically eliminate image backgrounds caused from autofluorescence, nonspecific labeling of dyes or markers, and probe fluorescence arising from out-of-focus image planes.", "With ImageJ, the colocalization ratio defined as (pixels of red)colocalized/(pixels of red)total is found to be (0.78±0.25) for 3 hours incubation and (0.10±0.07) for 24 hours incubation, counting 10˜20 cells to analyze the colocalization ratio (in some studies 10˜20 cells were counted).", "This ratio indicates that the endosome/lysosome escape efficiency, which is defined as (1−colocalization ratio), is low in the early stage of micelle uptake by cells, but high with longer incubation times.", "Table 3 lists the element atomic ratio for each investigated nanocrystals using EDX.", "With the increase of Mn levels in doping, the mole fractions of Mn atoms (Mn/(Ag+In+Zn+Mn+S)) that are incorporated in nanocrystals are increased—0.52%, 2.46%, and 2.96% for 0.025 mmol-, 0.075 mmol-, and 0.125 mmol-Mn-doped nanocrystals, respectively.", "TABLE 3 Measured Atomic Ratio by EDX Nanocrystals Mn Zn Ag In S AIZS/ZnS — 15.16 11.92 16.56 56.36 0.025 mmol-Mn:AIZS/ZnS 0.52 21.48 10.71 18.70 48.60 0.075 mmol-Mn: AIZS/ZnS 2.46 16.40 8.32 18.13 54.69 0.125 mmol-Mn:AIZS/ZnS 2.96 19.56 12.99 13.46 51.05 As shown in Table 4, the fast and slow decays for 0.075 mmol-Mn:AIZS/ZnS nanocrystals are corresponding to τ1 at around 40 μs and τ2 at around 614 μs.", "These lifetimes are much longer than those of undoped AIZS/ZnS nanocrystals measured at their own photoluminescence peak wavelength.", "Moreover, the photoluminescence decays of 0.075 mmol-Mn:AIZS/ZnS nanocrystals measured at different wavelengths (550, 585, 700 nm) also present their own τ1 and τ2 in tens of microseconds and hundreds of microseconds.", "Without being limited to a single theory, it currently is believed that a thin layer of Mn was formed in host AIZS/ZnS nanocrystals, and that Mn clusters or concentrated Mn dopants may exist in this layer.", "Experimentally, photoluminescence quenching with Mn doping in nanocrystals was observed, which indicates Mn-related defect formation.", "The fast decay of 0.075 mmol-Mn:AIZS/ZnS nanocrystals could result from radiative decay from trap states (caused by Mn related lattice strains or defects) to the valence band.", "The trap states could be aligned or overlapping with Mn 3d states, so that excited electrons in conduction band could be relaxed to the trap states directly or through Mn 3d states as relay states.", "The fast decay of the nanocrystals also could be from the emission of Mn dopants but with Mn—Mn spin coupling due to concentrated Mn in the Mn-doped layer.", "Additionally, because the AIZS/ZnS nanocrystals act as host nanocrystals, the fast decay may also arise from alloying of Mn with AIZS/ZnS nanocrystals in a thin layer.", "That means, the new alloys may have new bandgap structures or electron-hole recombination paths.", "It is also possible that the photoluminescence of 0.075 mmol-Mn:AIZS/ZnS nanocrystals is a synergistic effect of various photoluminescence mechanisms.", "Notably, from Table 4, the intensity percentage of the slow decayed photoluminescence (i.e., A2) is low as several percent over the whole photoluminescence intensity.", "Other nanocrystals with different Mn doping were measured in a similar way as 0.075 mmol-Mn:AIZS/ZnS nanocrystals.", "Their photoluminescence lifetime parameters are also listed in Table 4.The decay behavior of 0.125 mmol-Mn:AIZS/ZnS nanocrystals is very similar to that of 0.075 mmol-Mn:AIZS/ZnS nanocrystals.", "0.025 mmol-Mn:AIZS/ZnS nanocrystals have smaller τ1 and A2 parameters compared to the other two types of nanocrystals, and thus they present short average photoluminescence lifetimes.", "According to Table 3, the Mn level in 0.025 mmol-Mn:AIZS/ZnS nanocrystals is much less than that in other two types of nanocrystals.", "The small τ1 and A2 for 0.025 mmol-Mn:AIZS/ZnS nanocrystals could be related to the low Mn level in the hosts.", "Interestingly, according to the literature, a lower Mn level in host nanocrystals should produce a longer photoluminescence lifetime probably because the Mn—Mn distance is long.", "Such a conflict indicates that the Mn emission with Mn—Mn coupling could be existing but not be the major photoluminescence mechanism for the fast decay (corresponding to τ1) in Mn:AIZS/ZnS nanocrystals.", "Without being limited to a single theory, it currently is believed that he radiative decay from trap states or new electron-hole recombination pathways in the Mn-alloyed AISZ layer could be the dominant mechanisms for the fast decayed photoluminescence.", "With respect to A2, it may be relative to the ratio of the number of Mn pairs or diluted Mn dopants out of the Mn-doped layer over the number of all Mn dopants (in and out of the Mn-doped layer).", "For a low level Mn (0.025 mmol) in the doping reaction, the Mn spatial distribution in nanocrystals could be more uniform by diffusion when compared to high Mn levels, and thus the ratio of the number of Mn dopants out of the doped layer over the number of Mn dopants in and out of the doped layer (or alternatively A2) would be smaller.", "Notably, all prepared nanocrystals have their average photoluminescence lifetimes above one hundred microseconds, and they have good potential to be used as time-gated or time resolved probes in biosening/imaging.", "TABLE 4 Measured τ1 τ2 τavg Nanocrystals Wavelength (ms) A1 (ms) A2 (ms) 0.025 mmol- 525 nm 21.8 98.9% 332.6 1.1% 66.6 Mn:AIZS/ZnS 575 nm 30.1 98.1% 280.0 1.9% 67.5 625 nm 27.2 99.1% 517.0 0.9% 100.6 700 nm 17.5 99.8% 498.9 0.2% 39.9 0.075 mmol- 550 nm 33.0 97.0% 311.1 3.0% 95.3 Mn:AIZS/ZnS 585 nm 41.2 96.6% 519.1 3.4% 187.2 635 nm 40.1 96.0% 614.2 4.0% 263.5 700 nm 31.0 98.2% 480.8 1.8% 129.1 0.125 mmol- 550 nm 33.4 97.8% 321.1 2.2% 85.1 Mn:AIZS/ZnS 585 nm 41.3 96.7% 509.7 3.3% 178.6 642 nm 42.8 96.8% 496.4 3.2% 169.4 700 nm 32.3 98.2% 264.1 1.8% 62.9 FIGS.", "54A-54C include results obtained from analyzing the fluorescence lifetime of a control (organic dye Coumarin 153 in ethanol) and two Mn-doped composite embodiments of the present disclosure, which were prepared by encapsulating Mn-doped AZIS/ZNS nanocrystals (their average lifetimes at around 0.1 and 1 ms, respectively) with a zwitterionic polymeric coating as described herein.", "This data was obtained using an optical detection system, which was capable of measuring fluorescence above 520 nm.", "In view of the many possible embodiments to which the principles of the present disclosure may be applied, it should be recognized that the illustrated embodiments are only preferred examples of the present disclosure and should not be taken as limiting the scope.", "Rather, the scope of the present disclosure is defined by the following claims.", "We therefore claim as our invention all that comes within the scope and spirit of these claims." ] ]
Patent_15872763
[ [ "BALLISTICS SYSTEMS AND METHODS", "A scope may include an adjustment dial, which may be moved among a plurality of positions to configure the scope to compensate for projectile drops.", "The adjustment dial may be labeled with dial-calibration data, which may include one or more distance indicators and/or one or more windage hold-off indicators.", "The scope may be attached to a gun and the dial-calibration data may be at least partially generated using ballistics performance data based on shots fired by the gun.", "The dial-calibration data may be at least partially generated using shooting conditions.", "An electronic device may include a derived distance calculation module, which may be configured to use a distance to a target and actual shooting conditions to calculate a derived distance.", "The derived distance may be used in connection with an adjustment dial labeled with dial-calibration data at least partially generated using shooting conditions different from the actual shooting conditions." ], [ "1-21.", "(canceled) 22.A method of creating a label or an etching for an adjustment dial used to adjust a scope for a gun, said method comprising the steps of: receiving ballistics performance data, said ballistics performance data being associated with shots taken during a range test using the gun to which the scope is attached, wherein the adjustment dial is rotated among indicated positions during the range test; providing a dial-calibration data generation module for generating said dial-calibration data using said ballistics performance data; and creating said label or etching for said adjustment dial using said dial-calibration data, said label or etching including distance indicators, wherein said label or etching is created by at least one of an etching apparatus, a label making apparatus, and a printing apparatus.", "23.The method of claim 22, wherein said ballistics performance data comprises impact variance data from one or more shots taken during the range test.", "24.The method of claim 23, wherein said impact variance data comprises one or more distances above or below an expected impact point for one or more shots taken at a particular distance during the range test.", "25.The method of claim 22, wherein said ballistics performance data is received via the Internet.", "26.The method of claim 22, wherein said dial-calibration data generation module is implemented as a part of a web service.", "27.The method of claim 26, wherein said web service receives said ballistics performance data from a browser or other software program operating on a computing device.", "28.The method of claim 22 further comprising the step of: receiving expected shooting conditions data, said expected shooting conditions data including one or more conditions under which the gun is expected to be used; wherein said dial-calibration data is generated using said ballistics performance data and said expected shooting conditions data.", "29.The method of claim 28, wherein said expected shooting conditions data includes at least one of pressure data, temperature data, elevation data and humidity data at which the gun is expected to be used.", "30.The method of claim 22 further comprising the steps of: receiving expected shooting conditions data for conditions under which the gun is expected to be used, said expected shooting conditions data including one or more of the following: pressure data; temperature data; elevation data; and humidity data; generating said dial-calibration data using said ballistics performance data and said expected shooting conditions data.", "31.The method of claim 22 further comprising the steps of: receiving at least one of: ballistics coefficient data provided by a manufacturer of a projectile to be shot; muzzle velocity data provided by the projectile manufacturer; and shooting conditions data under which the range test is expected to be performed; and generating a projectile trajectory using at least one of said ballistics coefficient data, said muzzle velocity data and said range test expected shooting conditions data.", "32.The method of claim 31 further comprising the step of generating a range card using said projectile trajectory.", "33.The method of claim 32, wherein said range card includes: distance data indicating one or more distances from which projectiles may be shot as part of the range test; and dial position data indicating one or more positions for the adjustment dial to be used when said projectiles are shot by the gun to which the scope is attached.", "34.The method of claim 32, wherein said ballistics performance data may be entered into said range card.", "35.The method of claim 22, wherein said label or etching further includes windage hold-off indicators.", "36.A method of creating a label or an etching for an adjustment dial used to adjust a scope for a gun, said method comprising the steps of: receiving expected shooting conditions data, said expected shooting conditions data including one or more conditions under which the gun is expected to be used; providing a dial-calibration data generation module for generating dial-calibration data using said expected shooting conditions data; and creating said label or etching for said adjustment dial using said dial-calibration data, said label or etching including distance indicators, wherein said label or etching is created by at least one of an etching apparatus, a label making apparatus, and a printing apparatus.", "37.The method of claim 36, wherein said expected shooting conditions data includes at least one of pressure data, temperature data, elevation data, and humidity data at which the gun is expected to be used.", "38.The method of claim 36 further comprising the step of: receiving ballistics performance data, said ballistics performance data being associated with shots taken during a range test using the gun to which the scope is attached; wherein said dial-calibration data is generated using said ballistics performance data and said expected shooting conditions data.", "39.The method of claim 36, wherein said label or etching further includes windage hold-off indicators.", "40.A method of creating a label or an etching for an adjustment dial used to adjust a scope for a gun, wherein said adjustment dial is rotatable among a plurality of positions to configure the scope to compensate for projectile drops associated with various distances to a target, wherein said label or etching includes distance indicators, wherein the improvement comprises: receiving shooting conditions data under which a range test is performed, said range test shooting conditions data including at least one of the following: pressure data; temperature data; elevation data; and humidity data; receiving ballistics performance data obtained during said range test, said ballistics performance data including one or more distances above or below an expected impact point for one or more shots taken at a particular distance during the range test; providing a dial-calibration data generation module for generating dial-calibration data using said range test shooting conditions data and said ballistics performance data; and providing one of an etching apparatus, a label making apparatus, and a printing apparatus for creating said label or etching for said adjustment dial using said dial-calibration data.", "41.A system for creating a label or an etching for an adjustment dial used to adjust a scope for a gun, said system comprising: a dial-calibration data generation module that receives expected shooting conditions data and generates dial-calibration data using said expected shooting conditions data; and at least one of an etching apparatus, label making apparatus and printing apparatus that uses said dial-calibration data to create said label or etching for said adjustment dial.", "42.The system of claim 41 further comprising a ballistics calculation module that generates a projectile trajectory using one or more the of the following: ballistics coefficient data provided by a manufacturer of a projectile to be shot; muzzle velocity data provided by the projectile manufacturer; and shooting conditions data under which a range test is expected to be performed.", "43.The system of claim 42 further comprising a range card generation module that generates a range card, wherein said range card includes: distance data indicating one or more distances from which projectiles may be shot as part of the range test; and dial position data indicating one or more positions for the adjustment dial to be used when said projectiles are shot by the gun to which the scope is attached.", "44.The system of claim 41, wherein said expected shooting conditions data includes at least one of pressure data, temperature data, elevation data, and humidity data at which the gun is expected to be used.", "45.The system of claim 41, wherein said expected shooting conditions data is received by said dial-calibration data generation module via the Internet." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> BRIEF SUMMARY OF EMBODIMENTS OF THE INVENTION <EOH>A need therefore exists for systems and/or methods that eliminate or diminish the disadvantages and problems described above.", "One aspect is a scope that may include an adjustment dial, which may be moved among a plurality of positions to configure the scope to compensate for projectile drops.", "The adjustment dial may be labeled with dial-calibration data, which may include one or more distance indicators.", "In particular, the adjustment dial may be sized and configured to move among a plurality of positions to configure the scope to compensate for projectile drops associated with a range of distances to a target, and the distance indicators may be configured to indicate at least some of the distances within the range.", "Desirably, the distance indicators may allow a shooter to quickly select a distance to a target to configure the scope to compensate for a projectile drop associated with the selected distance.", "Another aspect is a scope that may include an adjustment dial that may be labeled with dial-calibration data, which may include one or more distance indicators and/or one or more windage hold-off indicators.", "The windage hold-off indicators may be configured to indicate a hold-off to compensate for an amount of deflection caused by a crosswind.", "To configure the scope to compensate for a projectile drop associated with a particular distance to a target, the shooter may move the adjustment dial to select the distance to the target.", "After the adjustment dial has been moved to select the distance to the target, a reference mark's position relative to various windage hold-off indicators may advantageously allow the shooter to quickly identify a hold-off tailored to the selected distance.", "The shooter may then apply the hold-off and fire the gun at the target.", "A further aspect is a scope that may include an adjustment dial that may be labeled with dial-calibration data, which may be at least partially generated using one or more of the following factors: sight-height data, muzzle velocity data, dial specification data, ballistics coefficient data, ballistics performance data, projectile-form-factor data, projectile caliber, projectile weight, air-density factors (such as, pressure data, temperature data, elevation data, humidity data and/or other air-density factors) and wind data.", "Significantly, using one or more of these factors may allow more accurate dial-calibration data to be generated—thus facilitating more accurate shooting with the scope.", "Of course, these factors are not required and other factors may be used to generate the dial-calibration data.", "Yet another aspect is a scope that may include an adjustment dial, which may be used in connection with a plurality of interchangeable components, such as turrets or other components.", "The components may be labeled with different dial-calibration data and may be sized and configured to be connected to and disconnected from a portion of the adjustment dial.", "For example, a first component may be labeled with first dial-calibration data that is at least partially generated using one set of shooting conditions, while a second component may be labeled with second dial-calibration data that is at least partially generated using a different set of shooting conditions.", "This may advantageously allow the adjustment dial to be used with different dial-calibration data tailored to the shooting conditions under which the scope is being used.", "If desired, the first and second dial calibration data may be at least partially generated based on one or more shots fired by a gum attached to the scope, which may further tailor the dial-calibration data to the gun.", "Still another aspect is a system that may include an electronic device, which may include a derived distance calculation module.", "The derived distance calculation module may be configured to use a distance to a target and actual shooting conditions to calculate a derived distance.", "The derived distance may be used in connection with a scope's adjustment dial labeled with dial-calibration data that was at least partially generated using shooting conditions different from the actual shooting conditions.", "Desirably, this may allow a shooter to accurately aim at a target under shooting conditions that are different from those used to generate the dial-calibration data, which may increase the scope's flexibility.", "These and other aspects, features and advantages of the present invention will become more fully apparent from the following detailed description of preferred embodiments and appended claims." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority and the benefit of U.S. provisional patent application 60/822,289, which was filed Aug. 14, 2006 and entitled RAPID FIELD BALLISTIC COMPENSATOR AND METHOD OF PROVIDING THE SAME, the disclosure of which is incorporated by reference in its entirety.", "BACKGROUND OF THE INVENTION Field of the Invention The present application relates generally to ballistics, guns and scopes.", "Description of Related Art Hunting and target shooting are very popular activities.", "Because accurately aiming guns may become more difficult as the distance to a target increases, scopes are often used in connection with guns.", "Generally, a scope may be connected to a gun and a shooter may look through the scope to view and aim at a target.", "But, even when using a scope, shooters may find it difficult and/or time consuming to accurately aim at a target.", "BRIEF SUMMARY OF EMBODIMENTS OF THE INVENTION A need therefore exists for systems and/or methods that eliminate or diminish the disadvantages and problems described above.", "One aspect is a scope that may include an adjustment dial, which may be moved among a plurality of positions to configure the scope to compensate for projectile drops.", "The adjustment dial may be labeled with dial-calibration data, which may include one or more distance indicators.", "In particular, the adjustment dial may be sized and configured to move among a plurality of positions to configure the scope to compensate for projectile drops associated with a range of distances to a target, and the distance indicators may be configured to indicate at least some of the distances within the range.", "Desirably, the distance indicators may allow a shooter to quickly select a distance to a target to configure the scope to compensate for a projectile drop associated with the selected distance.", "Another aspect is a scope that may include an adjustment dial that may be labeled with dial-calibration data, which may include one or more distance indicators and/or one or more windage hold-off indicators.", "The windage hold-off indicators may be configured to indicate a hold-off to compensate for an amount of deflection caused by a crosswind.", "To configure the scope to compensate for a projectile drop associated with a particular distance to a target, the shooter may move the adjustment dial to select the distance to the target.", "After the adjustment dial has been moved to select the distance to the target, a reference mark's position relative to various windage hold-off indicators may advantageously allow the shooter to quickly identify a hold-off tailored to the selected distance.", "The shooter may then apply the hold-off and fire the gun at the target.", "A further aspect is a scope that may include an adjustment dial that may be labeled with dial-calibration data, which may be at least partially generated using one or more of the following factors: sight-height data, muzzle velocity data, dial specification data, ballistics coefficient data, ballistics performance data, projectile-form-factor data, projectile caliber, projectile weight, air-density factors (such as, pressure data, temperature data, elevation data, humidity data and/or other air-density factors) and wind data.", "Significantly, using one or more of these factors may allow more accurate dial-calibration data to be generated—thus facilitating more accurate shooting with the scope.", "Of course, these factors are not required and other factors may be used to generate the dial-calibration data.", "Yet another aspect is a scope that may include an adjustment dial, which may be used in connection with a plurality of interchangeable components, such as turrets or other components.", "The components may be labeled with different dial-calibration data and may be sized and configured to be connected to and disconnected from a portion of the adjustment dial.", "For example, a first component may be labeled with first dial-calibration data that is at least partially generated using one set of shooting conditions, while a second component may be labeled with second dial-calibration data that is at least partially generated using a different set of shooting conditions.", "This may advantageously allow the adjustment dial to be used with different dial-calibration data tailored to the shooting conditions under which the scope is being used.", "If desired, the first and second dial calibration data may be at least partially generated based on one or more shots fired by a gum attached to the scope, which may further tailor the dial-calibration data to the gun.", "Still another aspect is a system that may include an electronic device, which may include a derived distance calculation module.", "The derived distance calculation module may be configured to use a distance to a target and actual shooting conditions to calculate a derived distance.", "The derived distance may be used in connection with a scope's adjustment dial labeled with dial-calibration data that was at least partially generated using shooting conditions different from the actual shooting conditions.", "Desirably, this may allow a shooter to accurately aim at a target under shooting conditions that are different from those used to generate the dial-calibration data, which may increase the scope's flexibility.", "These and other aspects, features and advantages of the present invention will become more fully apparent from the following detailed description of preferred embodiments and appended claims.", "BRIEF DESCRIPTION OF THE DRAWINGS The appended drawings contain figures of preferred embodiments to further illustrate and clarify the above and other aspects, advantages and features of the present invention.", "It will be appreciated that these drawings depict only preferred embodiments of the invention and are not intended to limit its scope.", "The invention will be described and explained with additional specificity and detail through the use of the accompanying drawings in which: FIG.", "1 is a perspective view of an exemplary scope; FIG.", "2 is a diagram of an exemplary reticle that may be used in connection with the scope shown in FIG.", "1, illustrating the reticle aiming at an exemplary target; FIG.", "3 is an exploded view of the scope shown in FIG.", "1; FIG.", "4 is another exploded view of the scope shown in FIG.", "1; FIG.", "5 is a front view of a portion of the scope shown in FIG.", "1, illustrating an exemplary adjustment dial; FIG.", "6 is a diagram of exemplary dial-calibration data that may be used to label the adjustment dial shown in FIG.", "5; FIGS.", "7A and 7B are flowcharts illustrating an exemplary method; FIG.", "8 is a block diagram illustrating an exemplary system; FIG.", "9 is a diagram of an exemplary range card; FIG.", "10 is a block diagram illustrating another exemplary system; FIG.", "11 is a perspective view of an exemplary electronic device; FIG.", "12 is a top view of the electronic device shown in FIG.", "11; FIG.", "13 is a side view of the electronic device shown in FIG.", "11; FIG.", "14 is a rear view of the electronic device shown in FIG.", "11; FIG.", "15 is a block diagram illustrating an exemplary system, illustrating an exemplary configuration of an electronic device; FIG.", "16 is a block diagram illustrating another exemplary system; and FIG.", "17 is a block diagram illustrating an exemplary configuration of an electronic device.", "DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention is generally directed towards ballistics systems and methods.", "The principles of the present invention, however, are not limited to ballistics systems and methods.", "It will be understood that, in light of the present disclosure, the ballistics systems and methods disclosed herein can be successfully used in connection with other types of systems and methods.", "A detailed description of the ballistics systems and methods now follows.", "A scope 10 shown in FIG.", "1 may be used to aim a gun, such as a rifle, revolver or other gun.", "In particular, the scope 10 may be sized and configured to be connected to the gun and a shooter may look through the scope to view and aim at a target.", "The scope 10 preferably comprises a rifle scope sized and configured to be connected to a rifle; however, the scope may be any other suitable scope and may be sized and configured to be connected to any other suitable gun, As shown in FIG.", "2, the scope 10 may include a reticle 12 that may facilitate aiming at a target 14.It will be appreciated that the reticle 12 may have any suitable shape and/or configuration and that a target 14 may include animals (such as deer, elk, bears, varmints and the like), inanimate objects (such as paper targets) or any other suitable target.", "As shown in FIGS.", "2-5, the scope 10 preferably includes an adjustment dial 16 (such as, a turret, a knob, a wheel, a disk or plate, or other adjustment mechanism), which may be used to adjust the scope.", "Desirably, the adjustment dial 16 may be rotated or otherwise moved among a plurality of positions to configure the scope to compensate for projectile drops associated with various distances to a target.", "In further detail, as shown in FIGS.", "5-6, the adjustment dial 16 may include dial-calibration data 18, which may include one or more distance indicators 20 (such as distance indicators 20a-h) configured to indicate a distance to a target.", "A distance indicator 20 may include, for example, a number or other symbol 22 indicating a distance to a target.", "The distance indicator 20 may also include a reference mark 24, which may be associated with the number or symbol.", "The distance indicator 20, however, does not require any number or symbol 22 and may simply include a reference mark 24, if desired.", "The dial-calibration data 18 preferably includes a plurality of distance indicators 20 configured to indicate various distances.", "For example, a first distance indicator 20 may indicate a first distance to a target and a second distance indicator 20 may indicate a second distance to a target.", "Desirably, when the first distance indicator 20 is aligned with a reference mark 26 of the scope 10, the scope is preferably configured to compensate for a first projectile drop associated with the first distance, and when the second distance indicator 20 is aligned with the scope's reference mark 26, the scope is preferably configured to compensate for a second projectile drop associated with the second distance.", "Consequently, the adjustment dial 16 may be rotated or otherwise moved within a range of positions in which the reference mark 26 is aligned with, or positioned between, various distance indicators 20.When the reference mark 26 is aligned with a distance indicator 20, the scope 10 is preferably configured to compensate for a projectile drop associated with the distance associated with the distance indicator.", "When the reference mark 26 is positioned between a pair of distance indicators 20, the scope 10 is preferably configured to compensate for a projectile drop associated with a distance between the distances associated with the pair of distance indicators.", "Desirably, the adjustment dial 16 may be rotated or otherwise moved within a range of discrete positions (using, for example, “clicks”) or within an at least substantially continuous range of positions.", "As shown in FIGS.", "5-6, the dial-calibration data 18 may include the distance indicators 20a-h configured to indicate 200 yards, 300 yards, 400 yards, 500 yards, 600 yards, 700 yards, 800 yards and 900 yards, respectively.", "It will be appreciated, however, that the dial-calibration data 18 may include any other suitable number of distance indicators configured to indicate any other suitable distances.", "As shown in FIGS.", "5-6, the dial-calibration data 18 may also include one or more windage hold-off indicators 28 (such as windage hold-off indicators 28a-g) configured to indicate a hold-off to compensate for an amount of deflection caused by a crosswind.", "An exemplary hold-off may include a number of hash marks, dots or other such features of a reticle; a minutes-of-angle (“MOA”) adjustment; and/or any other suitable hold-off.", "A windage hold-off indicator 28 may include, for example, a number or other symbol 30 indicating a hold-off for an amount of crosswind deflection.", "The windage hold-off indicator 28 may also include a reference mark 32, which may be associated with the number or symbol.", "The windage hold-off indicator 28, however, does not require any number or symbol 30 and may simply include a reference mark 32, if desired.", "The dial-calibration data 18 preferably includes a plurality of windage hold-off indicators 28 configured to indicate various hold-offs.", "For example, a first windage hold-off indicator 28 may indicate a first hold-off for a first amount of crosswind deflection and a second hold-off indicator 28 may indicate a second hold-off for a second amount of crosswind deflection.", "The windage hold-off indicators 28 may be configured to indicate various hold-offs depending, for example, upon the distance to a target.", "In further detail, when a windage hold-off indicator 28 is aligned with a distance indicator 20, the windage hold-off indicator 28 preferably indicates a hold-off for crosswind deflection from a target that is located at the distance associated with the distance indicator.", "When a windage hold-off indicator 28 is positioned between a pair of distance indicators 20, the windage hold-off indicator 28 preferably indicates a hold-off for crosswind deflection from a target that is located at a distance between the distances associated with the pair of distance indicators.", "Thus, the windage hold-off indicators 28 may be configured to indicate various hold-offs depending, for example, upon the distance to target.", "Significantly, the windage hold-off indicators 28 may advantageously allow a shooter to quickly and easily apply a hold-off tailored to a selected distance to a target.", "In further detail, to configure the scope 10 to compensate for a projectile drop associated with a particular distance to a target, the shooter may rotate or move the adjustment dial 16 within a range of positions in which the reference mark 26 is aligned with, or positioned between, various distance indicators 20, as discussed above.", "After the adjustment dial 16 has been rotated or moved to select the distance to the target, the reference mark 26 may be aligned with, or positioned between, various windage hold-off indicators 28, thus advantageously allowing the shooter to quickly identify a hold-off tailored to the selected distance to the target.", "In particular, if the reference mark 26 is aligned with a windage hold-off indicator 28, the shooter may know to use the hold-off indicated by the windage hold-off indicator 28.In addition, if the reference mark 26 is positioned between a pair of windage hold-off indicators 28, the shooter may know to use a hold-off between the hold-offs associated with the pair of windage hold-off indicators.", "Either way, the shooter may quickly identify a hold-off tailored to the selected distance to the target and then quickly apply that hold-off.", "Preferably, some or all of the windage hold-off indicators 28 may be configured to indicate various hold-offs for various amounts of deflection caused by a particular amount of crosswind, but at different distances to a target.", "For example, as shown by a notation 34 in FIG.", "6, the windage hold-off indicators 28 may be configured to indicate minute-of-angle (“MOA”) adjustments that compensate for particular amount of crosswind, such as a 5 mile-per-hour (“MPH”) crosswind.", "In this example, the windage hold-off indicator 28c includes a number “1” that indicates a 1 MOA adjustment for a 5 MPH crosswind, and the windage hold-off indicator 28g includes a number “2” that indicates a 2 MOA adjustment for a 5 MPH crosswind.", "In addition, in this example, the windage hold-off indicators 28a, 28b, 28d, 28e, 28f respectively indicate a ½ MOA adjustment, a ¾ MOA adjustment, a 1¼ MOA adjustment, a 1½ MOA adjustment and a 1¾ MOA adjustment for a 5 MPH crosswind.", "Thus, for instance, when the adjustment dial 16 has been rotated or moved to select a distance to a target (as discussed above) and the reference mark 26 is aligned with the windage hold-off indicator 28c, a shooter may quickly and easily see that a 1 MOA hold-off should be applied to adjust for a 5 MPH crosswind.", "Also, for instance, when the adjustment dial 16 has been rotated or moved to select a distance to a target (as discussed above) and the reference mark 26 is positioned between the windage hold-off indicators 28e, 28f, the shooter may quickly and easily see that a hold-off between 1½ MOA and 1¾ MOA should be applied to adjust for a 5 MPH crosswind.", "In some embodiments, where a windage hold-off indicator 28 may be configured to indicate a hold-off for a first amount of crosswind, a shooter may quickly and easily calculate a hold-off for a second amount of crosswind by multiplying the indicated hold-off by (y/x), where x is the first amount of crosswind and y is the second amount of crosswind.", "Thus, if the first amount of crosswind is 5 MPH, the indicated hold-off should be doubled when second amount of crosswind is 10 MPH (y/x=10/5=2) or tripled when the second amount of crosswind is 15 MPH (y/x=15/5=3).", "Thus, when the adjustment dial 16 has been rotated or moved to select a distance to a target (as discussed above) and the reference mark 26 is aligned with the windage hold-off indicator 28c, a shooter may quickly and easily see that a 1 MOA hold-off should be applied to adjust for a 5 MPH crosswind, a 2 MOA hold-off should be applied to adjust for a 10 MPH crosswind or a 3 MOA hold-off should be applied to adjust for a 15 MPH crosswind.", "In the examples above, the windage hold-off indicators 28 may have been illustrated to be configured to indicate hold offs for a 5 MPH crosswind; however, the windage hold-off indicators 28 may be configured to indicate hold-offs for a 1 MPH crosswind, a 2 MPH crosswind, a 5 MPH crosswind, a 10 MPH crosswind, a 20 MPH crosswind or any larger or smaller crosswind, if desired, In addition, although the windage hold-off indicators 28 may have been illustrated to be configured to indicate MOA hold-offs, the windage hold-off indicators 28 need not be configured to indicate MOA hold-offs and that the windage hold-off indicators may be configured to indicate other types of hold-offs.", "As shown in FIG.", "2, the reticle 12 may include one or more hash marks, dots or other such features sized and configured to indicate one or more hold-offs that may be quickly and easily used to aim at a target 14.For example, the reticle 12 may include hash marks 36a-h, which may indicate various hold-offs from a “zero point” 38.Thus, when the adjustment dial 16 has been rotated or moved to select a distance to a target and the shooter determines the hold-off that should be applied, the shooter may aim the hash mark 36 associated with that hold-off at the target 14.For instance, after determining that the hash mark 36c is associated with the proper hold-off, shooters may aim the hash mark 36c at a desired portion of the target 14, as shown in FIG.", "12, and may shoot their gun.", "As discussed below with reference to the various processes and systems, the dial-calibration data 18 may be at least partially generated using one or more of the following factors: sight-height data, muzzle velocity data, dial specification data, ballistics coefficient data, ballistics performance data, projectile-form-factor data, projectile caliber, projectile weight, air-density factors (suck as, pressure data, temperature data, elevation data, humidity data and/or other air-density factors) and wind data.", "Significantly, using one or more of these factors may allow more accurate dial-calibration data 18 to be generated—thus facilitating more accurate shooting with the scope 10.It will be appreciated, however, that the dial-calibration data 18 may be at least partially generated using these factors and/or other factors using other processes and/or systems.", "Thus, the exemplary processes and systems discussed below are not required and are merely used for illustration.", "An exemplary method 38 shown in FIGS.", "7A-7B may be used to make at least a portion of the scope 10, and an exemplary system 40 shown in FIG.", "8 may include a range card generation module 42, a ballistics calculation module 44, a dial-calibration data generation module 46, an etching apparatus 48, a label making apparatus 50 and a printing apparatus 52.Desirably, some or all of the method 38 may be performed by the system 40; the range card generation module 42; the ballistics calculation module 44; the dial-calibration data generation module 46; the etching apparatus 48; the label making apparatus 50; the printing apparatus 52; other systems, modules, apparatuses and the like; or any combination thereof.", "Of course, the entire method 38 need not be performed; and any part or parts of the method 38 may be performed alone, or in combination other methods, to provide a useful result.", "In further detail, the range card generation module 42 may receive sight-height data at block 54.The sight-height data preferably indicates a position of the scope 10 relative to a gun to which the scope is attached.", "For instance, the sight-height data may indicate the distance from the center axis of the scope 10 to the center axis of the barrel of the gun.", "At block 56, the range card generation module 42 may receive dial specification data.", "The dial specification data preferably indicates a range of positions among which the adjustment dial 16 may be rotated or moved and how those positions configure the scope 10 to compensate for projectile drops.", "For example, the dial specification data may indicate a one or more “clicks” among which the adjustment dial 16 may be rotated or moved and how the “clicks” alter the aim of the scope 10 to compensate for projectile drops, such as, a MOA adjustment provided by a “click.” At block 58, the ballistics calculation module 44 may receive first ballistics coefficient data.", "The first ballistics coefficient data may indicate a ballistics coefficient, such as a ballistics coefficient provided by a manufacturer of a projectile to be shot by the gun to which the scope 10 is attached.", "At block 60, the ballistics calculation module 44 may receive first muzzle velocity data.", "The first muzzle velocity data may indicate a muzzle velocity, such as a muzzle velocity provided by the projectile manufacturer.", "At block 62, the ballistics calculation module 44 may receive first shooting conditions data.", "The first shooting conditions data may indicate one or more shooting conditions under which a range test is expected to be performed.", "For example, the first shooting conditions data may include first pressure data, first temperature data, first elevation data and/or first humidity data, which may respectively indicate the barometric pressure, the temperature, the elevation and/or the humidity at which the range test is expected to be performed.", "Thus, as shown in FIG.", "7A, block 62 may include block 64 at which the ballistics calculation module 44 may receive the first pressure data, the first temperature data, the first elevation data and/or the first humidity data.", "The first shooting conditions data, however, does not require the first pressure data, the first temperature data, the first elevation data or the first humidity data and may include data indicating other shooting conditions.", "At block 66, the ballistics calculation module 44 may generate first projectile trajectory data configured to indicate a trajectory for a projectile.", "The ballistics calculation module 44 may generate the first projectile trajectory data using the first ballistics coefficient data received at block 58, the first muzzle velocity data received at block 60, some or all of the first shooting conditions data received at block 62 and/or other data (for instance, a drag model associated with a projectile's form factor).", "At block 68, the range card generation module 42 may generate a range card, such as a range card 70 shown in FIG.", "9.As shown in FIG.", "6, the range card 70 may include fields (such as fields 72, 74, 76, 78, 80, 82, 84) into which shooting conditions data, ballistics performance data and/or other data may be entered.", "The range card 70 may also include distance data 86 configured to indicate one or more distances from which projectiles may be shot as part of a range test.", "The range card 70 may further include dial position data 88 configured to indicate one or more positions for the adjustment dial 16 to be used when those projectiles are shot by the gun to which the scope 10 is attached.", "For example, the dial position data 88 may be configured to indicate one or more “clicks” of the adjustment dial 16.In further detail, the block 68 may include blocks 90, 92.At block 90, the range card generation module 42 may select a distance and, at block 92, may generate dial position data 88 associated with the distance selected at the block 90.Preferably, at block 92, the range card generation module 42 may generate dial position data 88 that indicates a position for the adjustment dial 16 that configures the scope 10 to compensate for an expected projectile drop at the selected distance.", "In particular, at block 92, the range card generation module 42 preferably generates this dial position data 88 using the first projectile trajectory generated at block 66, the sight-height data received at block 54, the dial specification data received at block 56 and/or other data.", "As shown in FIG.", "7A, blocks 90, 92 may be repeated for several different distances.", "For example, blocks 90, 92 may be repeated to generate dial position data 88 for 200 yards, 300 yards, 400 yards, 500 yards, 600 yards, 700 yards, 800 yards, 900 yards and/or other distances, as illustrated by the range card 70 shown in FIG.", "9.As shown in FIG.", "7B, a shooter may perform a range test at block 94.For example, the block 94 may include blocks 96, 98, 100 at which the shooter may enter second shooting conditions in the range card 70, take one or more shots at targets positioned at various distances using the gun to which the scope 10 is attached, and enter ballistics performance data associated with those shots in the range card 70.In further detail, the second shooting conditions may include second elevation data, second pressure data, second temperature data, and/second humidity data; and at block 96, the shooter may enter the second elevation data, the second pressure data, the second temperature data, and/the second humidity data into the fields 74, 76, 78, 80 of the range card 70.The second pressure data, the second temperature data, the second elevation data and the second humidity data may respectively indicate the barometric pressure, the temperature, the elevation and/or the humidity at which one or more of the shots are taken at block 98.The second shooting conditions data, however, does not require the second pressure data, the second temperature data, the second elevation data or the second humidity data and may include data indicating other shooting conditions.", "At block 98, a shooter may take one or more shots at some or all of the distances indicated by the distance data 86.In particular, after positioning the adjustment dial 16 to the position indicated by the dial position data 88, the shooter may take one or more shots at the distance indicated by its associated distance data 86.For example, after positioning the adjustment dial 16 to the position indicated by the dial position data 88c (twelve “clicks”), the shooter may take one or more shots at the distance indicated by its associated distance data 86c (400 yards).", "The shooter preferably takes multiple shots at each distance, for example, about five to ten shots at each distance.", "Of course, more or fewer shots may be taken, if desired.", "The shooter preferably takes the shots at block 98 using a particular type of projectile (for instance, projectiles sharing the same caliber, weight, form factor, manufacturer and/or the like) to obtain ballistics performance data for that particular type of projectile, as fired by the particular gun connected to the scope 10.As part of the range test performed at block 94, the shooter may “zero” the scope 10, for example, prior to taking some or all of the shots taken at the block 98.For instance, as shown in the range card 70, it may be expected that the adjustment dial 16 will require zero “clicks” to compensate for a projectile drop at 200 yards.", "In this example, one or more practice shots at 200 yards may be taken to determine a position of the adjustment dial 16 at which the scope 10 adequately compensates for projectile drop at 200 yards, and after taking these practice shots, the adjustment dial 16 may be recalibrated to a zero point.", "In further detail, as shown in FIGS.", "3-4, the adjustment dial 16 may include a turret 102 that may be selectively connected to a spindle 103 in a variety of relative positions using, for example, a screw 104.Consequently, with the adjustment dial 16 at which the scope 10 adequately compensates for projectile drop at 200 yards, the adjustment dial 16 may be recalibrated to a zero point by connecting the turret 102 to the spindle 103 at that zero point.", "It will be appreciated, however, that the shooter need not “zero” the scope 10 as part of the range test performed at the block 94.The adjustment dial 16 may also include a stop 105, a base 106 and a dust cover 107, if desired.", "The adjustment dial 16 may, as discussed above, rotate or move within a range of positions to select various distances to a target, and the stop 105 may be configured to limit that rotation or movement.", "In particular, the stop 105 may be configured to limit the rotation of the adjustment dial 16 to one revolution or a fraction of a revolution, which may help avoid confusion relating to rotating the adjustment dial 16 more than one times.", "In addition, this may allow the adjustment dial 16 to be quickly returned to a minimum or maximum rotational position, if desired.", "The stop 105 preferably has a generally ring-shaped configuration; however, the stop 105 may have other suitable shapes and/or configurations.", "It will be appreciated that the adjustment dial 16 does not require the stop 105 and that the adjustment dial 16 may be configured to rotate more than one revolution, if desired.", "At block 100, the shooter may record ballistics performance data associated with the shots taken at block 98.For example, the ballistics performance data may include an impact variance, such as a distance above or below an expected impact point.", "In particular, the ballistics performance data may include an impact variance for the distances at which the shots were taken, which the shooter may enter into the fields 84.The impact variance may comprise, for instance, an impact variance for a single shot taken at a particular distance or an average, a mean, a median or a mode of the impact variances for some or all of the shots taken the particular distance.", "The ballistics performance data may also include a muzzle velocity, which the shooter may enter into the field 72.The muzzle velocity may comprise, for instance, a muzzle velocity for a single shot taken during the range test or an average, a mean, a median or a mode of a muzzle velocity for some or all of the shots taken during the range test As shown in FIG.", "7B, at block 108, the ballistics calculation module 44 may receive the second shooting conditions entered at block 96 and may, at block 110, receive the ballistics performance data entered at block 100.At block 112, the ballistics calculation module 44 may calculate second ballistics coefficient data indicating a ballistics coefficient of the projectiles shot at block 98.For example, the ballistics calculation module 44 may calculate the second ballistics coefficient data using the shooting conditions received at block 108, the ballistics performance data received at block 110, the first projectile trajectory generated at block 66 and/or other data.", "As mentioned above, the shooter preferably takes the shots at block 98 using a particular type of projectile (for instance, projectiles sharing the same caliber, weight, form factor, manufacturer and/or the like) to obtain ballistics performance data for that particular type of projectile, as fired by the particular gun connected to the scope 10.Thus, if the second ballistics coefficient data is calculated using the ballistics performance data received at block 110, the second ballistics coefficient data may more accurately reflect the ballistics coefficient for this particular type of projectile, as fired by the particular gun connected to the scope 10.At block 114, the dial-calibration data generation module 46 may receive third shooting conditions data and may, at block 116, generate dial-calibration data 18.At block 118, the adjustment dial 16 of the scope may be labeled using the dial-calibration data generated at block 116.In further detail, the third shooting conditions data received at block 114 may indicate one or more expected shooting conditions under which the gun is expected to be used.", "For example, the third shooting conditions data may include third pressure data, third temperature data, third elevation data and/or third humidity data, which may respectively indicate the barometric pressure, the temperature, the elevation and/or the humidity at which the gun is expected to be used.", "The third shooting conditions data, however, does not require the third pressure data, the third temperature data, the third elevation data or the third humidity data and may include data indicating other shooting conditions.", "At block 116, the dial-calibration data generation module 46 may generate dial-calibration data 18, for example, the distance indicators 20, the windage hold-off indicators 28 and their relative positions.", "The dial-calibration data generation module 46 may generate dial-calibration data 18 using the second ballistics coefficient data calculated at block 112, the third shooting conditions data received at block 114, the ballistics performance data received at the block 110 (for instance, a muzzle velocity), the first projectile trajectory generated at block 66 and/or other data (such as the sight-height data received at block 54, the dial specification data received at block 56, and/or the first muzzle velocity received at block 60).", "Significantly, if the dial-calibration data generation module 46 generates the dial-calibration data 18 using the ballistics performance data received at the block 110 and/or the second ballistics coefficient data, the generated dial-calibration data 18 may be more accurately customized to the gun and type of projectiles shot during the range test performed at block 94.Moreover, if the dial-calibration data generation module 46 generates the dial-calibration data 18 using the sight-height data received at block 54 and/or the dial specification data received at block 56, the generated dial-calibration data 18 may be more accurately customized to the scope 10 and its position relative to the gun.", "Further, if the dial-calibration data generation module 46 generates the dial-calibration data 18 using the third shooting conditions data, the generated dial-calibration data 18 may be more accurately customized to particular shooting conditions under which the scope 10 and the gun are expected to be used.", "It will be appreciated, however, that the dial-calibration data generation module 46 may generate dial-calibration data 18 without the range test performed at block 94 or its associated ballistics performance data.", "For example, the dial-calibration data generation module 46 may receive sight-height data, dial specification data, ballistics coefficient data, muzzle velocity data, shooting conditions data, other data or any combination thereof and may use such data to generate dial-calibration data 18 at block 116.The ballistics coefficient data may indicate a ballistics coefficient, such as a ballistics coefficient provided by a manufacturer of a projectile to be shot by the gun to which the scope 10 is attached.", "The muzzle velocity data may indicate a muzzle velocity, such as a muzzle velocity provided by the projectile manufacturer.", "The shooting conditions data may indicate one or more shooting conditions under which the gun is expected to be used.", "At block 118, the adjustment dial 16 may be labeled using the dial-calibration data 18 generated at block 116.For example, at block 118, the etching apparatus 48 may use the generated dial-calibration data 18 to etch the distance indicators 20 and/or the windage hold-off indicators 28 into a portion of the adjustment dial 16, such as the turret 102.In another example, at block 118, the label making apparatus 50 may use the generated dial-calibration data 18 to create a label including the distance indicators 20 and/or the windage hold-off indicators 28, which label may be placed on a portion of the adjustment dial 16, such as the turret 102.In yet another example, at block 118, the printing apparatus 52 may use the generated dial-calibration data 18 to print the distance indicators 20 and/or the windage hold-off indicators 28 onto a portion of the adjustment dial 16, such as the turret 102.It will be appreciated, however, that the adjustment dial 16 may be labeled using the generated dial-calibration data 18 using other suitable means.", "If desired, a plurality of turrets 102 may be interchangeably used with the scope 10.In particular, some or all of the method 38 may be repeatedly performed to create a plurality of turrets 102 that may be interchangeably connected to the scope 10.Significantly, this may allow the turrets 102 to be labeled with different dial-calibration data 18 that is customized to different types of projectiles, different shooting conditions, etc.", "For example, a plurality of range tests may be performed to create different turrets 102 suitable for different types of projectiles.", "In addition, blocks 114, 116, 118 may be repeated to label multiple turrets 102 with dial-calibration data 18 generated using different shooting conditions.", "Thus, the turrets 102 may be customized to the different shooting conditions under which the scope 10 and the gun are expected to be used.", "In some instances, the different turrets 102 may include dial-calibration data 18 generated using different elevations (such as, 2,000 feet; 4,000 feet; 6,000 feet; 8,000 feet; etc.).", "In such instances, when at a first elevation, a shooter may connect (to the scope 10) a first turret 102 having first dial-calibration data 18 suitable for the first elevation; and when the shooter goes to a second elevation, the shooter may disconnect the first turret and replace it with a second turret 102 having second first dial-calibration data 18 suitable for the second elevation.", "As discussed above, the range card module 42, the ballistics calculation module 44 and/or the dial-calibration data generation module 46 may receive sight-height data, dial specification data, ballistics coefficient data, muzzle velocity data, shooting conditions data and/or other data.", "As discussed below, the modules may send and/or receive this data in a variety of different ways.", "In some embodiments, as shown in FIG.", "8, the range card module 42, the ballistics calculation module 44 and/or the dial-calibration data generation module 46 may be implemented as a part of a web service 120, which may be configured to receive this data via a network, such as the Internet, a local area network (LAN), a wide area network (WAN), other types of networks, or the like.", "For example, the range card module 42, the ballistics calculation module 44 and/or the dial-calibration data generation module 46 of the web service 120 may receive such data from a browser or other software program 122, which may be operating on a computing device 124, such as a desktop computer, a laptop computer, a palmtop computer, a personal digital assistant (PDA), a mobile phone, other computing devices, and the like.", "In particular, the browser 122 may receive and display a web page from the web service 120, and the web page may be configured to receive user input including sight-height data, dial specification data, ballistics coefficient data, muzzle velocity data, shooting conditions data, other data or any combination thereof.", "For instance, in one embodiment, the range card 70 generated at block 68 in FIG.", "7A may be a web page, which a person may print out.", "Using this print-out, a person may manually record the second shooting conditions data and/or ballistics performance data.", "Afterwards, the person may enter the second shooting conditions data and/or ballistics performance data into this range-card web page (or another web page) at blocks 96 and 100 in FIG.", "7B.", "The browser 122 may then send this user input to the web service 120 via the web page.", "The web service 120 may be hosted by, for example, a suitable hardware device.", "In some embodiments, as shown in FIG.", "10, the range card module 42, the ballistics calculation module 44 and/or the dial-calibration data generation module 46 may be implemented as a part of an electronic device 126, such as a computing device, a laser range finder or other suitable electronic device.", "The electronic device 126 may include a display 128 and one or more user input devices 130, such as a keyboard, pushbuttons, etc.", "The display 128 may display a user interface configured to receive user input including sight-height data, dial specification data, ballistics coefficient data, muzzle velocity data, shooting conditions data and/or other data.", "For instance, in one embodiment, the display 128 may display the range card 70 generated at block 68 in FIG.", "7A, and a person may use the user input device 130 to enter the second shooting conditions data and/or ballistics performance data into the displayed range card at blocks 96 and 100 in FIG.", "7B.", "It will be appreciated, however, that the range card module 42, the ballistics calculation module 44 and the dial-calibration data generation module 46 need not be implemented as a part of an electronic device 126 or a web service 120 and may be implemented in other suitable devices, systems, etc.", "As shown in FIGS.", "11-15, the system 40 may include an electronic device 132.The electronic device 132 preferably includes a derived-distance calculation module 134, which may be configured to use a distance to a target to calculate a derived distance that may be used in connection with an adjustment dial 16.As mentioned above, the adjustment dial 16 may include dial-calibration data 18 that may be customized to a set of shooting conditions under which the scope 10 and the gun are expected to be used.", "For example, the dial-calibration data 18 may include one or more distance indicators 20 customized to these expected shooting conditions.", "Significantly, when the scope 10 and the gun are to be used under actual shooting conditions that differ from these expected shooting conditions, the derived-distance calculation module 134 may advantageously use a distance to a target to calculate a derived distance that, when the adjustment dial 16 has been rotated or moved to select the derived distance, the scope 10 is configured to compensate for a projectile drop for the distance to the target under the actual shooting conditions.", "To calculate the derived distance, the derived-distance calculation module 134 may use the distance to the target and any other suitable data, for instance, the dial-calibration data 18, expected shooting conditions data, sight-height data, dial specification data, ballistics coefficient data, muzzle velocity data, actual shooting conditions data, and/or other data.", "The electronic device 132 may include a display 136, which may advantageously display the derived distance to a shooter who may quickly and easily rotate or otherwise move the adjustment dial 16 to select the derived distance.", "In further detail, the expected shooting conditions data may include the shooting conditions data received at block 114 of the method 38.The ballistics coefficient data may indicate a ballistics coefficient, such as a ballistics coefficient provided by a manufacturer of a projectile to be shot by the gun or a ballistics coefficient calculated at block 112.The muzzle velocity data may indicate a muzzle velocity, such as a muzzle velocity provided by the projectile manufacturer or a muzzle velocity measured at block 100.The actual shooting conditions data may indicate one or more shooting conditions under which the gun and the scope 10 are to be used.", "For example, the actual shooting conditions data may include pressure data, temperature data, elevation data and/or humidity data, which may respectively indicate the barometric pressure, the temperature, the elevation and/or the humidity at which the gun and the scope 10 are to be used.", "The actual shooting conditions data may also include wind data, which may indicate an amount and/or direction of wind present when the gun and the scope are to be used.", "The actual shooting conditions data may further include compass heading data and/or tilt data, which may respectively indicate the direction and/or the tilt (e.g., incline or decline) at which the gun and the scope 10 are to be used.", "The actual shooting conditions data may be different from the expected shooting conditions data in a variety of ways.", "For example, the actual shooting conditions data may include additional types of data (such as wind data, compass heading data and/or incline data) that may not have been included in the expected shooting conditions used to generate the adjustment dial's dial-calibration data 18.Also for example, the actual shooting conditions data and the expected shooting conditions data may indicate different conditions, such as different barometric pressures, temperatures, elevations and/or humidity.", "The derived-distance calculation module 134 may receive the dial-calibration data 18, the expected shooting conditions data, the sight-height data, the dial specification data, the ballistics coefficient data, the muzzle velocity data, the actual shooting conditions data and/or other data using a variety of means.", "In some embodiments, for example, the electronic device 132 may include a barometric pressure sensor 138, a temperature sensor 140, an elevation sensor 142, a humidity sensor 144, a wind sensor 146, a compass heading sensor 148 and/or a tilt sensor 150, which may sense actual shooting conditions and respectively send associated actual shooting conditions data to the derived-distance calculation module 134.In particular, the barometric pressure sensor 138, the temperature sensor 140, the elevation sensor 142, the humidity sensor 144, the wind sensor 146, the compass heading sensor 148 and the tilt sensor 150 may respectively send pressure data, temperature data, elevation data, humidity data, wind data, compass heading data and tilt data to the derived-distance calculation module 134.In some embodiments, the electronic device 132 may include a GPS module that may provide the elevation data or a location from which the elevation data may be derived.", "In addition, as best seen in FIGS.", "11-15, the electronic device 132 may be a laser range finder, which may include a laser transmit and receive device 152.The laser transmit and receive device 152 may be configured to transmit and receive light, for example, to help the laser range finder determine a distance to a target or other item, which the derived-distance calculation module 134 may use in calculating the derived distance.", "It will be appreciated, however, that the electronic device 132 does not require a laser transmit and receive device 152 and that the electronic device 132 need not be laser range finder.", "For instance, the electronic device 132 may be a laser range finder, a computing device or any other suitable electronic device.", "In some embodiments, the derived-distance calculation module 134 may receive the dial-calibration data 18, the expected shooting conditions data, the sight-height data, the dial specification data, the ballistics coefficient data and/or the muzzle velocity data from the computing device 124 (FIGS.", "8 and 15) or the electronic device 126 (FIGS.", "10 and 16).", "In particular, the electronic device 132 may include an interface 154, such as a USB port, FireWire® port or other interface, via which the computing device 124 or the electronic device 126 may send such data to the derived-distance calculation module 134 of the electronic device 132.The interface 154, however, is not required and some or all of the features of the electronic device 120 may be integrated into the electronic device 132, as shown in FIG.", "17.It will be appreciated that the electronic device 132 may receive the dial-calibration data 18, the expected shooting conditions data, the sight-height data, the dial specification data, the ballistics coefficient data, the muzzle velocity data, the actual shooting conditions data and/or other data via sensors, user input (using, for instance, one or more user input devices 156) or any other suitable means.", "As shown in FIGS.", "15-17, the electronic device 132 may include a windage hold-off calculation module 158, which may be configured to calculate a hold-off to compensate for an amount of deflection caused by a crosswind.", "An exemplary hold-off may include a number of hash marks, dots or other such features of a reticle; a minutes-of-angle (“MOA”) adjustment; and/or any other suitable hold-off.", "To calculate the hold-of, the windage hold-off calculation module 158 may use the distance to a target, the dial-calibration data 18, the expected shooting conditions data, the sight-height data, the dial specification data, the ballistics coefficient data, the muzzle velocity data, the actual shooting conditions data and/or other data that the derived-distance calculation module 134 may or may not use to calculate the derived distance.", "In some embodiments, the windage hold-off calculation module 158 may receive this data in a variety of ways including, but not limited to, the ways discussed above that the derived-distance calculation module 134 may receive this data.", "The display 136 of the electronic device 132 may advantageously display the hold-off to a shooter who may quickly and easily apply the hold-off.", "If desired, the display 136 of the electronic device 132 may advantageously be configured to display the hold-off, the derived distance, or both.", "As shown above, the methods and systems described above can be implemented using one or more modules, which may include, for example, software and/or hardware.", "The software and/or hardware may include web services, object-oriented software components, class components, task components, processes, functions, attributes, procedures, subroutines, segments of program code, drivers, firmware, microcode, circuitry, data, databases, data structures, tables, arrays, variables, field programmable gate arrays (FPGAs), application-specific integrated circuits (ASICs), processors, computing devices, firmware, other software components and/or other hardware components.", "If desired, the functionality provided for in the modules discussed above may be combined into fewer modules or further separated into additional modules, if desired, Although this invention has been described in terms of certain preferred embodiments, other embodiments apparent to those of ordinary skill in the art are also within the scope of this invention.", "Accordingly, the scope of the invention is intended to be defined only by the claims which follow." ] ]
Patent_15872764
[ [ "CARBONACEOUS NANOPARTICLES, METHODS OF MAKING SAME AND USES THEREOF", "Compositions of carbonaceous nanoparticle fabrication and their use for electrode materials in supercapacitors are provided.", "The supercapacitor includes a first electrode having a first substrate and carbonaceous nanoparticles; a second electrode comprising a second substrate and carbonaceous nanoparticles; a separator positioned between the first electrode and the second electrode; and an electrolyte.", "Methods of making an electrode for a supercapacitor are also provided." ], [ "1.A supercapacitor, comprising: a first electrode comprising a first substrate and carbonaceous nanoparticles; a second electrode comprising a second substrate and carbonaceous nanoparticles; a separator positioned between the first electrode and the second electrode; and an electrolyte, wherein the carbonaceous nanoparticles are made according to the method of claim 1.2.The supercapacitor of claim 1, wherein the first substrate comprises a first metal.", "3.The supercapcacitor of claim 2, wherein the first metal comprises stainless steel.", "4.The supercapacitor of claim 1, wherein the second substrate comprises a second metal.", "5.The supercapacitor of claim 4, wherein the second metal comprises stainless steel.", "6.The supercapacitor of claim 1, wherein the separator comprises plastic.", "7.The supercapacitor of claim 6, wherein the plastic comprises polypropylene.", "8.The supercapacitor of claim 6, wherein the plastic comprises a composition resistant to attack by acids and bases.", "9.The supercapacitor of claim 1, wherein the electrolyte comprises potassium hydroxide.", "10.The supercapacitor of claim 1, wherein the supercapacitor has an energy density greater than or equal to about 2 mMwh/cm3.11.The supercapacitor of claim 1 having a power density, wherein the power density comprises greater than or equal to about 4 kW/cm3.12.A method of making an electrode for a supercapacitor, comprising: applying to a substrate a suspension of a liquid dispersant comprising carbonaceous nanoparticles formed according to a method, said method comprising: reacting a first carbon source with a second carbon source in the presence of a nitrogen source in a DC arc furnace to form a composite nanoparticle, wherein the second carbon source comprises a dopant, wherein the composite nanoparticle comprises a crystalline carbon phase having an amorphous phase comprising dopant or carbide; and removing the amorphous second layer to form the carbonaceous nanoparticle; drying the suspension of carbonaceous nanoparticles on the substrate; and compacting the dried suspension of carbonaceous nanoparticles on the substrate with a uniaxial pressure less than or equal to 1000 MPa to create an electrode.", "13.The method of claim 12, wherein the liquid dispersant comprises an alcohol." ], [ "<SOH> BACKGROUND <EOH>A supercapacitor, which is also known as an ultracapacitor and formerly known as an electric double-layer capacitor (EDLC)) is a high-capacity electrochemical capacitor with capacitance values up to 10,000 farads at 1.2 volt that bridge the gap between electrolytic capacitors and rechargeable batteries.", "They typically store 10 to 100 times more energy per unit volume or mass than electrolytic capacitors, can accept and deliver charge much faster than batteries, and tolerate many more charge and discharge cycles than rechargeable batteries.", "They are however 10 times larger than conventional batteries for a given charge.", "Supercapacitors are used in applications requiring many rapid charge/discharge cycles rather than long term compact energy storage: within cars, buses, trains, cranes and elevators, where they are used for recovery energy from braking, short-term energy storage or burst-mode power delivery.", "Smaller units are used as memory backup for static random-access memory (SRAM).", "The salient feature of a supercapacitor is its ability to deliver much higher power density than a conventional battery.", "Supercapacitors are usually large devices owing to specific design requirements.", "Supercapacitors are constructed with two metal foils (current collectors), each coated with an electrode material such as activated carbon, which serve as the power connection between the electrode material and the external terminals of the capacitor.", "Specifically to the electrode material is its very large surface area.", "The activated carbon is electrochemically etched, so that the surface of the material is about a factor 100,000 larger than the smooth surface.", "Supercapacitor electrodes are generally thin coatings applied and electrically connected to a conductive, metallic current collector.", "Electrodes must have good conductivity, high temperature stability, long-term chemical stability (inertness), high corrosion resistance and high surface areas per unit volume and mass.", "Other requirements include environmental friendliness and low cost.", "The amount of double-layer as well as pseudocapacitance stored per unit voltage in a supercapacitor is predominantly a function of the electrode surface area.", "Therefore supercapacitor electrodes are typically made of porous, spongy material with an extraordinarily high specific surface area, such as activated carbon.", "Additionally, the ability of the electrode material to perform faradaic charge transfers enhances the total capacitance.", "Generally, the smaller the electrode's pores, the greater the capacitance and energy density.", "However, smaller pores increase (ESR) and decrease power density.", "Applications with high peak currents require larger pores and low internal losses, while applications requiring high energy density need small pores.", "Carbon electrodes for use in superconductors have been made with various carbon sources, including activated carbon, activated carbon fibers, carbon aerogel, carbide-derived carbon, graphene sheets, carbon nanotubes, onion-shaped carbon nanoparticles and template carbon." ], [ "<SOH> BRIEF SUMMARY <EOH>In a first aspect, a method of making a carbonaceous nanoparticle is provided.", "The method includes two steps.", "The first step includes reacting a first carbon source with a second carbon source in a nitrogen source in a DC arc furnace to form a composite nanoparticle.", "The second carbon source includes a dopant.", "The composite nanoparticle includes a crystalline carbon phase having an amorphous phase comprising dopant or carbide.", "The second step includes removing the amorphous second layer to form the carbonaceous nanoparticle.", "In a second aspect, a supercapacitor is provided.", "The supercapacitor includes a first electrode having a first substrate and carbonaceous nanoparticles; a second electrode comprising a second substrate and carbonaceous nanoparticles; a separator positioned between the first electrode and the second electrode; and an electrolyte.", "The carbonaceous nanoparticles are preferably made according to the method of the first aspect.", "In a third aspect, a method of making an electrode for a supercapacitor is provided.", "The method includes the several steps.", "The first step includes applying to a substrate a suspension of a liquid dispersant comprising carbonaceous nanoparticles formed according to the method of the first aspect.", "The second step includes drying the suspension of carbonaceous nanoparticles on the substrate.", "The third step includes compacting the dried suspension of carbonaceous nanoparticles on the substrate with a uniaxial pressure less than or equal to 1000 MPa to create an electrode.", "These and other features, objects and advantages of the present invention will become better understood from the description that follows.", "In the description, reference is made to the accompanying drawings, which form a part hereof and in which there is shown by way of illustration, not limitation, embodiments of the invention." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a divisional of U.S. non-provisional patent application Ser.", "No.", "14/671,758, filed Mar.", "27, 2015, which claims benefit of priority under 35 U.S.C.", "119 to U.S. provisional patent application Ser.", "No.", "61/970,988, filed Mar.", "27, 2014, and entitled “Carbonaceous Nanoparticles, Methods of Making Same and Uses Thereof,” the content of which is herein incorporated by reference in its entirety.", "STATEMENT OF GOVERNMENT INTEREST This invention was made with government support under DMR-0843962 awarded by the National Science Foundation.", "The government has certain rights in the invention.", "FIELD The present disclosure relates to methods for making carbon-based nanoparticles and their uses in supercapacitors.", "BACKGROUND A supercapacitor, which is also known as an ultracapacitor and formerly known as an electric double-layer capacitor (EDLC)) is a high-capacity electrochemical capacitor with capacitance values up to 10,000 farads at 1.2 volt that bridge the gap between electrolytic capacitors and rechargeable batteries.", "They typically store 10 to 100 times more energy per unit volume or mass than electrolytic capacitors, can accept and deliver charge much faster than batteries, and tolerate many more charge and discharge cycles than rechargeable batteries.", "They are however 10 times larger than conventional batteries for a given charge.", "Supercapacitors are used in applications requiring many rapid charge/discharge cycles rather than long term compact energy storage: within cars, buses, trains, cranes and elevators, where they are used for recovery energy from braking, short-term energy storage or burst-mode power delivery.", "Smaller units are used as memory backup for static random-access memory (SRAM).", "The salient feature of a supercapacitor is its ability to deliver much higher power density than a conventional battery.", "Supercapacitors are usually large devices owing to specific design requirements.", "Supercapacitors are constructed with two metal foils (current collectors), each coated with an electrode material such as activated carbon, which serve as the power connection between the electrode material and the external terminals of the capacitor.", "Specifically to the electrode material is its very large surface area.", "The activated carbon is electrochemically etched, so that the surface of the material is about a factor 100,000 larger than the smooth surface.", "Supercapacitor electrodes are generally thin coatings applied and electrically connected to a conductive, metallic current collector.", "Electrodes must have good conductivity, high temperature stability, long-term chemical stability (inertness), high corrosion resistance and high surface areas per unit volume and mass.", "Other requirements include environmental friendliness and low cost.", "The amount of double-layer as well as pseudocapacitance stored per unit voltage in a supercapacitor is predominantly a function of the electrode surface area.", "Therefore supercapacitor electrodes are typically made of porous, spongy material with an extraordinarily high specific surface area, such as activated carbon.", "Additionally, the ability of the electrode material to perform faradaic charge transfers enhances the total capacitance.", "Generally, the smaller the electrode's pores, the greater the capacitance and energy density.", "However, smaller pores increase (ESR) and decrease power density.", "Applications with high peak currents require larger pores and low internal losses, while applications requiring high energy density need small pores.", "Carbon electrodes for use in superconductors have been made with various carbon sources, including activated carbon, activated carbon fibers, carbon aerogel, carbide-derived carbon, graphene sheets, carbon nanotubes, onion-shaped carbon nanoparticles and template carbon.", "BRIEF SUMMARY In a first aspect, a method of making a carbonaceous nanoparticle is provided.", "The method includes two steps.", "The first step includes reacting a first carbon source with a second carbon source in a nitrogen source in a DC arc furnace to form a composite nanoparticle.", "The second carbon source includes a dopant.", "The composite nanoparticle includes a crystalline carbon phase having an amorphous phase comprising dopant or carbide.", "The second step includes removing the amorphous second layer to form the carbonaceous nanoparticle.", "In a second aspect, a supercapacitor is provided.", "The supercapacitor includes a first electrode having a first substrate and carbonaceous nanoparticles; a second electrode comprising a second substrate and carbonaceous nanoparticles; a separator positioned between the first electrode and the second electrode; and an electrolyte.", "The carbonaceous nanoparticles are preferably made according to the method of the first aspect.", "In a third aspect, a method of making an electrode for a supercapacitor is provided.", "The method includes the several steps.", "The first step includes applying to a substrate a suspension of a liquid dispersant comprising carbonaceous nanoparticles formed according to the method of the first aspect.", "The second step includes drying the suspension of carbonaceous nanoparticles on the substrate.", "The third step includes compacting the dried suspension of carbonaceous nanoparticles on the substrate with a uniaxial pressure less than or equal to 1000 MPa to create an electrode.", "These and other features, objects and advantages of the present invention will become better understood from the description that follows.", "In the description, reference is made to the accompanying drawings, which form a part hereof and in which there is shown by way of illustration, not limitation, embodiments of the invention.", "BRIEF DESCRIPTION OF THE DRAWINGS The features, objects and advantages other than those set forth above will become more readily apparent when consideration is given to the detailed description below.", "Such detailed description makes reference to the following drawings.", "FIG.", "1A depicts the morphological characterization of as-synthesized BN-HCDN, wherein high-resolution SEM image of nanoparticles collected from the chamber wall.", "FIG.", "1B depicts TEM image of a cluster of these nanoparticles on a holey carbon grid.", "FIG.", "1C depicts high-resolution TEM images of as-synthesized BN-HCDN.", "FIG.", "2A shows EELS analysis results for the as-synthesized BN-HCDN, wherein STEM image of as elected BN-HCDN to be mapped by EELS.", "FIG.", "2B shows EELS spectrum of particle from FIG.", "2A showing the B, C, and N edges of EELS.", "FIG.", "2C shows elemental mapping image of B (188-208 eV).", "FIG.", "2D shows elemental mapping image of N (401-421 eV).", "FIG.", "2E shows the over lay image of FIGS.", "2C and 2D.", "FIG.", "3A illustrates the morphological characterization of annealed BN-HCDN (BN-1H), wherein high-resolution annular dark field-STEM images are shown.", "FIG.", "3B illustrates bright field high-resolution STEM images of single BN-1H particle.", "FIG.", "3C illustrates a comparison of electron diffraction patterns between as-synthesized BN-HCDN (left) and BN-1H (right).", "Bright spots in the right half indicate graphitic (crystalline) characteristics of BN-1H, compared with the hazy pattern of as-synthesized BN-HCDN in the left half.", "FIG.", "4A illustrates a porosity analysis from the BET measurement, wherein gas adsorption/desorption analysis using N2 (77.4 K) of the BN-HCDN before and after the annealing process for high-resolution N2 isotherms.", "FIG.", "4B depicts the pore-size distribution of FIG.", "4A (calculated by using a slit NLDFT model).", "FIG.", "5A depicts XPS spectrum analysis for the N, BN, and BN-1H samples for a survey spectrum.", "FIG.", "5B depicts a high-resolution spectrum of C 1s.", "FIG.", "5C depicts a high-resolution spectrum of B 1s.", "FIG.", "5D depicts a high-resolution spectrum of N 1s.", "FIG.", "6A illustrates electrochemical characterization in three electrode configuration in a comparison study among the samples of N, as-synthesized BN, and BN-1H, wherein CV curves measured in 6 M KOH electrolyte from −1.0 to 0 V at 100 mV s−1.FIG.", "6B illustrates galvanostatic charge/discharge profiles at the current density of 3 Ag−1.FIG.", "6C depicts an in-depth study of BN-1H, wherein Galvanostatic charge/discharge profiles at different current densities obtained in 6 M of KOH.", "FIG.", "6D depicts CV curves obtained in different electrolyte systems of 6 M KOH and 1 M of H2SO4 at scan rate of 1 V s−1.FIG.", "6E depicts an in-depth study of BN-1H, wherein Galvanostatic charge/discharge profiles at different current densities obtained in 1 M of H2SO4.FIG.", "7A depicts electrochemical characterization of thin film supercapacitor, wherein CVs profiles of a thin film supercapacitor of BN-1H in a 6 M KOH, at different scan rates, from low to high.", "FIG.", "7B depicts galvanostatic charge/discharge curves at different current densities.", "FIG.", "7C depicts complex plane plot of the impedance analysis, with a magnification for the high-frequency region in the inset.", "FIG.", "7D depicts the real and imaginary part of the capacitance (C′ and C″) as a function of frequency.", "Very low relaxation time constant τ0 (8.5 ms) is confirmed.", "While the present invention is amenable to various modifications and alternative forms, exemplary embodiments thereof are shown by way of example in the drawings and are herein described in detail.", "It should be understood, however, that the description of exemplary embodiments is not intended to limit the invention to the particular forms disclosed, but on the contrary, the intention is to cover all modifications, equivalents and alternatives falling within the spirit and scope of the invention as defined by the embodiments above and the claims below.", "Reference should therefore be made to the embodiments and claims herein for interpreting the scope of the invention.", "DETAILED DESCRIPTION The compositions and methods now will be described more fully hereinafter with reference to the accompanying drawings, in which some, but not all permutations and variations of embodiments of the invention are shown.", "Indeed, the invention may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.", "These embodiments are provided in sufficient written detail to describe and enable one skilled in the art to make and use the invention, along with disclosure of the best mode for practicing the invention, as defined by the claims and equivalents thereof.", "Likewise, many modifications and other embodiments of the compositions and methods described herein will come to mind to one of skill in the art to which the invention pertains having the benefit of the teachings presented in the foregoing descriptions and the associated drawings.", "Therefore, it is to be understood that the invention is not to be limited to the specific embodiments disclosed and that modifications and other embodiments are intended to be included within the scope of the appended claims.", "Although specific terms are employed herein, they are used in a generic and descriptive sense only and not for purposes of limitation.", "Glossary of Terms and Definitions Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of skill in the art to which the invention pertains.", "Although any methods and materials similar to or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods and materials are described herein.", "Moreover, reference to an element by the indefinite article “a” or “an” does not exclude the possibility that more than one element is present, unless the context clearly requires that there be one and only one element.", "The indefinite article “a” or “an” thus usually means “at least one.” As used herein, “about” means within a statistically meaningful range of a value or values such as a stated concentration, length, molecular weight, pH, sequence identity, time frame, temperature or volume.", "Such a value or range can be within an order of magnitude, typically within 20%, more typically within 10%, and even more typically within 5% of a given value or range.", "The allowable variation encompassed by “about” will depend upon the particular system under study, and can be readily appreciated by one of skill in the art.", "Ranges recited herein include the defined boundary numerical values as well as sub-ranges encompassing any non-recited numerical values within the recited range.", "For example, a range from about 0.01 mM to about 10.0 mM includes both 0.01 mM and 10.0 mM.", "Non-recited numerical values within this exemplary recited range also contemplated include, for example, 0.05 mM, 0.10 mM, 0.20 mM, 0.51 mM, 1.0 mM, 1.75 mM, 2.5 mM 5.0 mM, 6.0 mM, 7.5 mM, 8.0 mM, 9.0 mM, and 9.9 mM, among others.", "Exemplary sub-ranges within this exemplary range include from about 0.01 mM to about 5.0 mM; from about 0.1 mM to about 2.5 mM; and from about 2.0 mM to about 6.0 mM, among others.", "Supercapacitor Designs with Nitrogen and Boron Co-Doped Carbon HDCN A cost-effective approach to fabricate high performance supercapacitors using specially designed and processed nitrogen and boron co-doped carbon HDCN is presented.", "The process requires assembly of closely-interconnected nanoparticles with large internal/external surfaces and plenty of sub-nanochannels for high speed charge transport.", "The supercapacitor is formed under 700 MPa of uniaxial pressure to reduce the internal resistance of the device and to improve the power density.", "This integrated approach provided a power density of nearly 4.58 kW cm−3.In addition, an energy density of 2.45 mWhcm−3 was also obtained.", "The described fabrication process can be easily scalable for manufacturing.", "The disclosed hierarchical design and assembly of the HCDN is based on vertically integrating optimal materials-performance at each length scale, ranging from the atomic to micrometers in length.", "At the atomic level, an abundance of active sites for chemical activity and charge accumulation are needed.", "At this level, doping the carbon with nitrogen and boron will alter its electronic properties as well as seeding the structural change for the growth of the HCDN during synthesis.", "At the sub-nano level, abundant channels for efficient mass/charge transport of electrolyte species are needed within the nano-structure.", "At the nano-structure level, it is necessary to assure that the HCDN has a shape for optimum packing of charges and good electrical contact among the HCDN particles for rapid charge transport.", "Finally, at the micron level, the HCDN must be assembled and mechanically compacted between the two electrodes to deliver the maximum power density.", "Thus the elastic properties of the HCDN were part of the design consideration.", "The HCDN synthesis and characterization at each length scale is presented.", "A discussion of the supercapacitor fabrication and product performance is presented in the examples.", "In view of the foregoing, including the examples presented herein, specific aspects of the invention are now presented.", "In a first aspect, a method of making a carbonaceous nanoparticle is provided.", "The method includes two steps.", "The first step includes reacting a first carbon source with a second carbon source in the presence of a nitrogen source in a DC arc furnace to form a composite nanoparticle.", "The second carbon source includes a dopant.", "The composite nanoparticle includes a crystalline carbon phase having an amorphous phase comprising dopant or carbide.", "The second step includes removing the amorphous second layer to form the carbonaceous nanoparticle.", "In one respect of the first aspect, the first carbon source is selected from graphite and carbon black.", "In another respect, the dopant includes boron.", "In another respect, the dopant includes boron carbide (B4C).", "In another respect, the ratio of the weight percent of the first carbon source to the second carbon source comprising is from about 2:1 to about 20:1.In one respect, the ratio of the weight percent of the first carbon source to the second carbon source includes a ratio of about 9:1.In another respect, the nanoparticle includes a substantially spherical shape having nanohorns and nanographene sheets.", "In a second aspect, a supercapacitor is provided.", "The supercapacitor includes a first electrode having a first substrate and carbonaceous nanoparticles; a second electrode comprising a second substrate and carbonaceous nanoparticles; a separator positioned between the first electrode and the second electrode; and an electrolyte.", "The carbonaceous nanoparticles are preferably made according to the method of the first aspect.", "In one respect, the supercapacitor includes a first substrate having a first metal.", "In another respect, the supercapcacitor includes a first metal having stainless steel.", "In another respect, the supercapcacitor includes a second substrate having a second metal.", "In another respect, the supercapcacitor includes a second metal having stainless steel.", "In another respect, the supercapcacitor includes a separator having plastic.", "In another respect, the supercapcacitor includes a plastic having polypropylene.", "In another respect, the supercapcacitor includes a plastic having a composition resistant to attack by acids and bases.", "In another respect, the supercapcacitor includes an electrolyte comprising potassium hydroxide.", "In another respect, the supercapcacitor includes an energy density greater than or equal to about 2 mMwh/cm3.In another respect, the supercapcacitor includes a power density of greater than or equal to about 4 kW/cm3.In a third aspect, a method of making an electrode for a supercapacitor is provided.", "The method includes the several steps.", "The first step includes applying to a substrate a suspension of a liquid dispersant comprising carbonaceous nanoparticles formed according to the method of the first aspect.", "The second step includes drying the suspension of carbonaceous nanoparticles on the substrate.", "The third step includes compacting the dried suspension of carbonaceous nanoparticles on the substrate with a uniaxial pressure less than or equal to 1000 MPa to create an electrode.", "In one respect of the third aspect, the liquid dispersant comprises an alcohol.", "In some respect, the alcohol is selected from a group consisting of ethanol, methanol and isopropyl alcohol.", "In another respect, the substrate comprises a metal.", "In some respects, the metal comprises stainless steel.", "In other respects, the first step of applying comprises spraying.", "For example, in some respects, spraying comprises electro-spraying.", "In other respects, the third aspect includes additional steps, such as repeating the steps to create an additional electrode.", "In this regard, the electrode of this aspect further includes the step of providing a separator.", "In some respects, separator comprises plastic.", "In other respects, the plastic comprises polypropylene.", "In yet other respects, the method includes additional steps of sandwiching the separator between the electrodes to create a dry supercapacitor.", "In this regard, the method includes an additional step of providing electrolyte.", "In this regard, the electrolyte comprises potassium hydroxide.", "In this regard, the method further includes the step of soaking the dry supercapacitor with the electrolyte to create the supercapacitor.", "EXAMPLES The invention will be more fully understood upon consideration of the following non-limiting examples, which are offered for purposes of illustration, not limitation.", "Example 1.Nanoparticle Design and Synthesis BN-HCDN Fabrication and Structural Analysis The first goal is to synthesize a HCDN with near spherical shape consisting of doped crystalline frame-work having numerous internal nano-channels and sharp tips for the transport and accumulation of charges.", "To achieve such an architecture the following two-step processing sequence was taken to synthesize the unique HCDN: First, a composite nanoparticle was synthesized consisting of fine lamella layers of crystalline carbon sandwiched between amorphous layers of nitride and/or carbide materials.", "Second, the amorphous layers of the composite nanoparticle were selectively etched away by heating the sample in air at 450° C. to produce the desired structure.", "DC arcs have been extensively used in nano-carbon studies [see, for example, V. P. Dravid et al., Science 1993, 259:1601; X. K. Wang et al., App.", "Phys.", "Lett.", "1995, 66:2430; N. Li et al., Carbon 2010, 48:255; B. Lee et al., Energy Environ.", "Sci.", "2012, 5:6941; X. Lin et al., Appl.", "Phys.", "Lett.", "1994, 64:181].", "To perform the first step, a DC arc was configured as a high temperature furnace where a hole in the cathode serves as a crucible that can be filled with materials to be incorporated into the products [S. P. Doherty et al., Carbon 2006, 44:1511].", "An optimal mixture of 90% graphite powder and 10% B4C powder was used to synthesize the HCDN particles.", "B4C was used primarily as a source for boron doping; nitrogen gas was used as the nitrogen source for co-doping.", "The arc was operated with high purity nitrogen at 300 Torr and a temperature around 3,000° C. Under these conditions, a composite HCDN was obtained as proposed in step one described above.", "Nitrides and carbides in the HCDN remain amorphous while carbon achieved its crystalline form.", "(Note: HCDN samples were also synthesized with pure hydrogen and nitrogen gas only.", "However, the electrical-chemical properties of these samples were inferior, most likely due to their structural properties.", "Thus, this study focused on the B—N co-doped samples.)", "The morphology of the as synthesized B—N co-doped HCDN (BN) collected from the chamber wall is shown in the SEM image (FIG.", "1A).", "The spherical particles are quite uniform in size, and they range between 40-60 nm.", "A transmission electron microscopy (TEM) image, FIG.", "1B, provides a closer view of a cluster of these particles on a holey carbon grid.", "FIG.", "1C is a higher magnification of a composite particle showing the crystalline carbon as the matrix embedded with amorphous materials.", "To study the composition of the as synthesized HCDN, electron energy loss spectroscopy (EELS) was used to map the locations of B, N, and C in the individual particles, and X-ray photoelectron spectroscopy (XPS) was used to study the average amount of each element and their local bonding environment over an assembly of nanoparticles.", "FIG.", "2A shows a scanning transmission electron microscopy (STEM) image of a selected nanoparticle mapped by EELS.", "STEM images and EELS were acquired in a probe-corrected JEOL ARM200F equipped with a GIF Tridiem operated at 80 kV.", "The electron energy loss spectrum of the whole nanoparticle clearly shows the B, C, and N edges (FIG.", "2B).", "From this mapping (FIG.", "2C-E) it is clear that both B and N are uniformly present across the nanoparticle indicating that the crystalline and amorphous phases of the composite HCDN are homogeneously distributed within the particle.", "In the second step of the synthesis, the amorphous materials in the composite HCDN was selectively etch-removed by heating the sample at 450° C. in air.", "FIG.", "3A is an annular dark field image of a typical nanoparticle (BN-1H) after 1 hour of treatment to remove the amorphous material from the nanoparticles.", "It shows how the dense nano-composite particle has transformed into a nano-porous particle.", "By further focusing on a single nanoparticle (FIG.", "3B), it is quite revealing to see the transformation of a compact composite nanoparticle into a crystalline carbon “skeleton” framework, which consists of densely populated inter-nested carbon nano-horns [M. Yudasaka et al., Carbon nanotub.", "2008, 111:605] and twisted nano-graphite sheets.", "The inset to FIG.", "3B shows the fine structure of a typical nano-horn.", "An electron diffraction pattern (FIG.", "3C) was obtained from as deposited BN-HCDN (left half circle) and after 1-hour heat treatment, BN-1H (right half circle).", "The existence of diffraction spots in the rings indicates the presence of randomly oriented carbon crystallites in the BN-1H sample.", "From the TEM images, it is clear that nanochannels have been created within the particle that will improve charge transport.", "Second, the presence of horn-shaped nanostructures will help to induce charging effects around their tips and promote local chemical activities.", "Thirdly, the inter-connection among the annealed HCDN particles will further enhance the charge flow among the assemblies of these nanoparticles.", "BN-HCDN Nanoparticle Porosity While it is clear from the micrographs that selective etching can transform a dense composite HCDN particle into a highly nano-porous crystalline carbon nanoparticle, it is also desirable to quantify the change in porosity that takes place.", "To this end, a Brunauer-Emmett-Teller (BET) pore structure analysis was carried out.", "The isotherms are Type II IUPAC classification without adsorption hysteresis (FIG.", "4A).", "The observed adsorption isotherm appears to be representative of an adsorption isotherm on a flat surface.", "The etching process results in a remarkably enhanced N2 adsorption uptake at low relative pressure (P/Po), which is indicative of a huge increase in nanoporosity.", "Moreover, continuous N2 uptake can be observed in the relative pressure range of 0.3˜0.6, which also implies the presence of large increase in porosity.", "The pore size distribution was calculated using the quenched solid density functional theory (QSDFT) method that was part of the Quarda Win software package (Quanta chrome Instruments, USA), assuming a slit pore geometry.", "From this analysis there is only a minor amount of pores with characteristics in the micropore range for the as synthesized BN sample.", "On the other hand, there are two obvious peaks in the micropore range for the etched sample: one very sharp peak just above 1 nm and another broad peak (with one tenth the height) between 2-3 nm (FIG.", "4B).", "This dramatic increase in pore volume around 1 nm can be attributed to the presence of numerous nanochannels and/or sub-nanochannels formed by the intertwined nano-carbon layers and nano-horns left behind in the etched nanoparticle discussed above [S. Bandow et al., Chem.", "Phys.", "Lett.", "2000, 321:514; S. Utsumi et al., J. Phys.", "Chem.", "B 2005, 109:14319].", "As a result, the surface area and pore volume of the etched sample increase over the unetched sample from 193.3 m2 g−1 to 554.3 m2 g−1, and from 0.27 cm3 g−1 to 0.51 cm3 g−1, respectively.", "It should be pointed out here that these values remain nearly the same after the HCDN film is compacted with a pressure of 700 MPa.", "BN-HCDN XPS Analysis Extensive XPS studies were performed on the BN and BN-1H particles.", "From the survey spectrum of the N and BN samples (FIG.", "5A) indicates the incorporation of N and B into these materials.", "The nitrogen and boron concentrations in the as grown co-doped sample, BN, are about 4 at % and 3 at % respectively (Table 1).", "TABLE 1 Summary of XPS peak analysis for N, BN, and BN-1H samples.", "C1 B2 N3 Sample C-B C-C C-N C-O Content B-C B-N B-CO2 B-O Content N-6 N-5 N-Q N — 60.9% 21.1% 18.0% — — — 4.0 at % 71.7% 21.8% 6.5% BN 6.7% 69.7% 13.2% 10.4% 3.0 at % 18.7% 50.5% 30.8% — 4.1 at % 58.8% 36.6% 4.6% BN-1h 3.6% 72.3% 10.5% 13.5% 0.8 at % 15.7% 48.7% 27.7% 7.9% 2.2 at % 41.1% 51.1% 7.8% 1C-B (283.4 eV), C-C (284.6 eV), C-N (286.2 eV), and C-O (288.3 eV) 2B-C (189.5 eV), B-N (190.6 eV), B-CO2 (192 eV), and B-O (193 eV) 3N-6 (Pyridinic-398.5 eV), N-5 (Pyrrolic-400.5 eV), and N-Q (Quaternary-401.2 eV) The predominate asymmetric C 1s peak, shown in FIG.", "5B, indicates the existence of C—N, C—B, and/or C—O bonds in addition to C—C bonds.", "The C 1s spectrum could be deconvoluted into four peaks at 283.5, 284.7, 286.3, and 288.4 eV; these were assigned to C—B, sp2 C═C, C—N, and/or C—O bonds, and π-π sp2 satellite transitions respectively [S. Maldonado et al., Carbon 2006, 44:1429; W. J. Hsieh et al., Carbon 2005, 43:820; P. Hammer et al., J. Vac.", "Sci.", "Technol.", "A 2000, 18:2277; H. Valdés et al.", "Langmuir 2002, 18:2111; K. László et al., Carbon 2001, 39, 1217; Y. C. Lin et al., Appl.", "Phys.", "Lett.", "2010, 96:133110; S. T. Jackson et al., Appl.", "Surf Sci.", "1995, 90:195].", "The B1s core level can be divided into maximum 4 peaks of B—O (193 eV), BCO2 (192 eV), B—N (190.6 eV) and B—C (189.5 eV) (FIG.", "5C) [W. J. Hsieh et al.", "Carbon 2005, 43:820; Y. Kang et al., Carbon 2013, 61:200; S. H. Sheng et al., J.", "Mater.", "Chem.", "2012, 22:390].", "The relatively large amount of B—N bonding indicates that N from the reaction gas reacts preferentially with B over C when B is present.", "The high resolution N1s peak can be deconvoluted into 3 components (FIG.", "5D); N-6 (398.6 eV), N-5 (400.6 eV), and N-Q (401.6 eV) [W. J. Hsieh et al., Carbon 2005, 43:820; Y. C. Lin et al.", "Appl.", "Phys.", "Lett.", "2010, 96:133110].", "N-6 corresponds to pyridinic substitution in the carbon lattice, N-5 to pyrrolic substitution in the carbon lattice and/or B—N bonding, and N-Q to graphitic substitution in the carbon lattice.", "Considering large amount of B—N bonding indicated from the B1s spectra, it can be assumed that there are also large amount of N—B bonding, along with the pyrrolic N substitution, in peak N-6 in the B doped samples.", "As depicted above, due to the nature of ternary mixture in BN sample, there are large amount of different bonding at lower binding energy comparing with N sample (including N-6 and N-5).", "Although the amount of Band N were somewhat decreased by the 1h annealing, sufficient quantities of B (0.8 at %) and N (2.2 at %) remain to change the surface chemistry of the BN-1h sample thereby increasing its electrochemical activities.", "Moreover, it should be noted that most of the nitrogen species present are as pyridinic (N-6) and pyrrolic (N-5) substitution.", "This is because nitrogen can act as an edge termination agent during the graphene growth in a role similar to hydrogen in a hydrogen arc growth [Y. C. Lin et al., Appl.", "Phys.", "Lett.", "2010, 96:133110].", "These N-6 and N-5 species are favorable for accumulating charges during supercapacitor operation due to their appropriate electron configuration and binding energy [F. M. Hassan et al., J.", "Mater.", "Chem.", "A 2013, 1:2904].", "Nitrogen bonding around the nano-graphitic edges favors pyridinic substitution [Lin et al.", "(2010)]; density function theory (DFT) calculation indicates this should produce a p-type material [D. Usachov et al., NanoLett.", "2011, 11:5401].", "XPS also indicates pyrrolic N-substitution where the Fermi level is in the middle of the gap.", "After annealing in air, the amount of oxygen species (such as hydroxyl, ester, ketone, and carboxylic groups) on the surface of the HCDN were slightly increased from ca.", "7 at % to 10 at %.", "Addition of these groups further enhances the redox reaction for more charge accumulation, and also increases the hydrophilic surface property for better wettability of the materials, which eventually increase the overall electrochemical performance of BN-1H HCDN [M. Inagakia et al., J.", "Power Sources 2010, 195:7880].", "The difference in surface wettability of these samples with contact angle measurements was shown, wherein the BN-1H sample has the best wettability.", "BN-HCDN Sample Densification The HCDN nanoparticles were compacted or densified into a film under uniaxial pressure for the fabrication of supercapacitors.", "The densification of the HCDN film is needed to optimize the device performance to obtain both the highest energy density and power density.", "This requires the optimization of at least two important parameters: charge density (amount of charge per volume) stored in the capacitor, and the supercapacitor charging and discharging rate (which requires the minimization of internal resistance of the device).", "In addition, the device needs to possess long-term stability through cycling.", "Densification is thus a key step to achieving these properties.", "To assure the nanoparticle film was not over-compressed (beyond its elastic limit), in-situ nano-indentation measurements were performed on single selected BN-1H HCDN particles in a HR-TEM.", "An AFM-TEM in situ holder from Nanofactory AB was used to perform the compression experiments [G. Casillas et al., Philos.", "Mag.", "2012, 92:4437; G. Casillas et al., Jose-Yacaman, Nanoscale.", "2013, 5:6333].", "Briefly, the nanoparticles are drop-casted onto an Au wire, which is mounted in to the AFM-TEM holder and once inside the TEM, they are compressed by a Si tip.", "The deflection of the cantilever is used to compute the load applied on the particles and the area of contact is estimated from the TEM images.", "The results showed that a single nanoparticle was able to withstand ˜1000 MPa of stress at the contact point without any deformation (except for the sharp tips).", "Beyond this stress the nanoparticle started to compress plastically.", "According to these results, an uniaxial pressure of 700 MPa was used to ensure that the nanoparticles were not damaged in the film formation process discussed below (See, for example the BET isotherm result for compressed BN-1H sample).", "BN-HCDN Electrical Measurement Hall measurements were performed on normally ˜300 μm thick BN-1H co-doped HCDN films.", "The HCDN particles were compacted under a uniaxial pressure of 700M Pa to form the films.", "The Hall mobility was determined to be ˜2 cm2V−1·s−1 with a p-type carrier density of 5×1019 cm−3 to yield a conductivity of ˜15 S cm−1.This carrier density is about one order of magnitude higher than an N-doped sample grown in the nitrogen arc without boron doping, while the p-type mobility is the same.", "Thus, the BN co-doped sample is more conductive by roughly a factor of 10.This information is very important to the design of the supercapacitor.", "To achieve high rates of charging and discharging, the internal resistance of the device needs to be very low.", "BN-HCDN Electrochemical Analysis As a demonstration of the advantage of its unique structure, the electrochemical activity of B—N co-doped HCDN material was compared with N-doped HCDN samples using a three-electrode cell.", "FIG.", "6A shows typical cyclic voltammograms (CV) for a three-electrode cell in 6 M KOH at a scan rate of 100 mVs−1.The as-deposited BN-HCDN exhibits a much larger CV curve than the N sample corresponding to superior electrochemical activities for storing charges.", "Considering the similar values for surface area (193.3 m2g−1 for the BN sample and 215 m2g−1 for the N sample), the increase in electrochemical activity is attributed to the synergetic effect of B—N co-doping in the carbon structure as discussed earlier.", "Sharp response at the voltage changing point represents the fast charge/discharge characteristics owing to the favorable surface chemical properties of B—N co-doping effects.", "Heteroatom doping in the carbon framework changes the electronic properties of the material with the heteroatoms being more favorable for the attraction of ions in the electrolyte compared to that of the carbon atoms, thus inducing pseudo capacitance [F. M. Hassan et al., J.", "Mater.", "Chem.", "A 2013, 1:2904].", "Additionally, the presence of heteroatoms in the carbon matrix can enhance the wettability (hydrophilicity) between electrolyte and electrode materials [E. Iyyamperumal et al., ACS Nano 2012, 6:5259].", "Therefore, the heteroatom doping could not only introduce extra pseudo capacitance but also enhance the electric double-layer capacitance.", "The B—N co-doped synergetic effect becomes more significant after 1-hour annealing process.", "Due to the highly increased conductivity of the BN-1H sample relative to the BN sample, faster response can be obtained resulting in a nearly rectangular shaped CV curve.", "Moreover, characteristics of the redox reaction became more obvious showing the appearance of “humps” in the CV curves (FIG.", "6A).", "Capacitive behaviors can also be observed, exhibiting linear behavior during the galvanostatic charge/discharge experiments performed at 3 Ag−1 (FIG.", "6B).", "The specific capacitance of BN-1H sample was calculated from the discharging curves with values of as high as 277 Fg−1 at a current density of 0.2 Ag−1.For the further validation of the advantages of B—N co-doping, an electrochemical activity test was also performed in acidic media (1 M of H2SO4).", "FIG.", "6C shows charging/discharging scans as a function of current for 6 M KOH solution, while FIG.", "6E shows that for 1 M H2SO4 solution.", "FIG.", "6D compares the differences in the electrolyte solutions in C-V plots.", "The specific capacitance of the BN-1H was calculated from galvanostatic charge/discharge curves according to the relation Cspec=I·tm−1·V−1, where I is the charge/discharge current, t is the discharge time, m is the mass of electrode material and V is the voltage difference.", "The highest capacitance values, calculated from the discharge curves, were 277 Fg−1, and 245 Fg−1 in 6 M KOH and 1 M H2SO4, respectively.", "Considering the surface area (554.3 m2g−1), this value can be converted to a considerably high value of 49.9 μFcm−2 which is much higher value than 10˜30 μFcm−2 which are typically showed in carbon materials [L. L. Zhang and X. S. Zhao, Chem.", "Soc.", "Rev.", "2009, 38:2520; J. Han et al., ACS Nano 2013, 7:19].", "This means the BN-1H has highly electrochemical-active surface characteristics.", "Example 2.Supercapacitor Fabrication Fabrication and Properties of Two-Electrode BN-HCDN Supercapacitors The above results demonstrate BN-1H particles have superior electro-chemical properties and thus should be used for the fabrication of the two-electrode supercapacitors.", "The steps taken to prepare the devices are as follows: BN-1H carbon nanoparticles processed from the arc furnace as describe above are electro-sprayed onto two identical stainless steel substrates to form thin films of BN-1H.", "In order to retain high efficiency (low internal resistance), no organic binding material has been used in assembly the BN-1H nanoparticles.", "The thin films are further compacted under a pressure of 700 MPa to a thickness of ca.", "1 μm.", "The two densified electrodes are sandwiched together mechanically with a polypropylene separator layer between them.", "This assembly is then soaked in the 6 M of KOH electrolyte.", "FIG.", "7 shows the characteristics of a typical supercapacitor.", "Cyclic voltammograms (CVs) were recorded at scan rates from 1,000 mV s−1 to 10,000 mV s−1 to test the power capability of the thin film supercapacitor (FIG.", "7A).", "Almost perfect rectangular shaped CV curves, up to the very high scan rate, indicate low resistance, as well as its high power characteristics for the device.", "The galvanostatic charge/discharge curves at three current densities are shown in FIG.", "7B.", "The specific capacitance was calculated from the discharge curves with values of 28.3, 28.1, and 28.1 F cm−3 obtained at current densities of 600, 1200, and 3000 mA cm−3, respectively (FIG.", "7B).", "Electrochemical impedance spectroscopy (EIS) further confirms the superior power performance of the compacted BN-1H thin film supercapacitor.", "The vertical feature in the Nyquist plot of BN-1H shows the nearly ideal capacitive behavior of the cell.", "The equivalent series resistance obtained from the intercept of the plot on the real axis is only 0.34 Ωcm−2.From the expanded high-frequency range data (FIG.", "7C, inset), a transition between the RC semicircle and the migration of electrolyte was observed at a frequency ca.", "3000 Hz.", "The diffusion of electrolyte ions stopped ca.", "400 Hz, and thereafter the full capacitance was reached.", "The thin film supercapacitor of BN-1H shows superior frequency response with a very small relaxation time constant to of 8.5 ms (τ0 being the minimum time needed to discharge all the energy from the device with an efficiency of greater than 50% [P. Banerjee, I. Perez, L. Henn-Lecordier, S. B. Lee, G. W. Rubloff, Nat.", "Nanotech.", "2009, 4:292]; FIG.", "7D).", "This small time constant for BN-1H is very promising compared with previously reported values for planar micro-supercapacitors: activated carbon (700 ms) [D. Pech et al., Nat.", "Nanotech.", "2010, 5:651], onion-like carbon (26 ms) [Pech (2010)] and direct laser writing graphene device (19 ms) [M. F. El-Kady and R. B. Kaner, Nat.", "Commun.", "2013, 4:1475].", "The measured electrical properties of the BN-1H two-electrode supercapacitor give a high power density (4.58 kW cm−3) and energy density (2.45 mWh cm−3).", "Furthermore, the thin film BN-1H supercapacitors show excellent cycling stability, retaining ca.", "90% of the initial performance after 10,000 charge/discharge cycles.", "Synthesis of Boron and Nitrogen Doped Arc Carbon Materials The arc system used in this study is described in detail elsewhere [L. S. Wang et al., Appl.", "Phys.", "A 2007, 87:1].", "Briefly, the arc consists of two electrodes.", "The cathode is a solid ⅜-inch diameter randomly oriented graphite (ROG) rod.", "The anode is a cup-like structure fabricated from a ⅜-inch diameter ROG rod with a 3/16-inch diameter hole, 4 inch deep, in the center of the end facing the cathode.", "The hole, or cup, in the anode cup is filled with tightly compacted graphite powder; as a boron (B) source 10 wt % B4C was mixed with graphite powder.", "After the chamber was evacuated, 300 Torr of Nitrogen (N) gas was introduced.", "Nitrogen was used as nitrogen source.", "A 100 Amp DC arc was applied to heat the graphite powder inside the hole.", "A potential of 27-28 V was maintained between the electrodes by adjusting the spacing between them, typically 0.5 to 0.7 inch.", "A typical synthesis experiment lasts ca.", "7 min.", "The arc soot deposited on the surface of chamber was collected.", "Some graphite impurities exist in the as-collected soot, so a purification process was performed to remove un-desired carbon species.", "First, the as-collected sample was dispersed in a solution of water and ethanol (9:1) and then sonicated to make a highly dispersed suspension.", "The suspension was centrifuged to remove heavy graphitic balls from the arc soot.", "After the centrifugation, the supernatant was freeze-dried overnight to yield the purified arc soot.", "This sample is designated as the as-synthesized BN-HCDN herein.", "For the control experiment, pure graphite powder without B4C addition was introduced into the arc discharge process to produce soot doped with only nitrogen, which is designated as the N sample.", "For the synthesis of the BN-1H sample, as-synthesized carbon soot underwent a heat treatment in air at 450° C. to etch-remove of the amorphous portion of the material.", "Characterization of Synthesized Materials Scanning electron microscopic (SEM) images were obtained using a Hitachi SU8030 field emission SEM (FESEM).", "Transmission electron microscopy (TEM), selected area electron diffraction (SAED) studies were performed using a JEOL 2100F FAST TEM working at 200 kV.", "Structural characterization of the arc carbon was done by X-ray diffraction (XRD, D/MAX-A, Rigaku) featuring Jade Analysis software.", "The surface area and pore size distribution of the synthesized HCDN were measured by nitrogen adsorption/desorption isotherms, using a Micrometrics ASAP 2020 system.", "The sample was degassed at 398 K under vacuum overnight before analysis, to remove any adsorbed impurities.", "The surface area was measured using the Brunauer-Emmett-Teller (BET) model for relative pressures and the distribution of pore dimensions was calculated using the Barrett-Joyner-Halenda (BJH) model.", "XPS spectra were recorded on a Thermo Scientific ESCALAB 250Xi.", "All binding energies (BEs) are referred to the graphitic C 1s line at 284.7 eV.", "Compressing Test for the BN-1H Sample The in situ TEM experiments were performed in a JEOL JEM-2010F.", "Images were recorded with an AMT CCD camera.", "The sample was diluted in ethanol, ultrasonicated and drop-casted on to a 0.25-mm Au wire that was mounted on an N force-probing holder (AFM-TEM holder) from Nanofactory Instruments AB.", "The sample is mounted on a piezotube which enables three-dimensional movement with sub-nanometer precision.", "For load measurements, this holder relies on the deflection of a silicon cantilever with a sharp tip.", "These experiments were carried out with a cantilever of a spring constant of 2.3 nNm−1.Finally, the stress can be estimated by assuming a circular area of contact and measuring the diameter from the TEM micrographs.", "Electrochemical Characterization of Synthesized Materials Three-Electrode Test: Electrochemical measurements were performed using an AUTOLAB PGASTAT 302N potentiostat with a standard three-electrode setup in both 6 M of KOH and 1 M H2SO4.Working electrodes were prepared by drop-casting the samples on a glassy carbon electrode: A Pt plate and an Ag/AgCl electrode saturated with KCl were used as a counter electrode and reference electrode, respectively.", "Cyclic voltammograms were recorded within the range from 0 to −1 V in KOH and from 0 to 1 V in H2SO4 at various scan rates.", "Galvanostatic charge/discharge was carried out within the same voltage range of CV measurement at various current densities.", "Electrochemical impedance spectroscopy (EIS) measurement was carried out by applying voltage amplitude of 10 mV at OCV (open circuit voltage) in the frequency range from 100 kHz to 50 mHz.", "Calculations: The capacitance of each device was calculated from the galvanostatic charge/discharge curves using the formula: For a three electrode configuration: C electrode = i × Δ   t Δ   V Where i (A) is the discharge current, Δt (s) is the discharge time, ΔV (V) is the voltage change (excluding the iR drop) within the discharge time.", "Gravimetric specific capacitance was calculated by dividing capacitance by the mass of electrode material.", "For a two electrode thin film configuration: C device = i × Δ   t Δ   V × 4 Where i (A) is the discharge current, Δt (s) is the discharge time, ΔV (V) is the voltage change (excluding the iR drop) within the discharge time, the multiplier of 4 adjusts the capacitance of the cell and the combined mass of two electrodes to the capacitance and mass of a single electrode.", "Specific capacitance was calculated based on the volume of the device according to the following formula: Volumetric capacitance (Cv)=Cdevice/V where V refers to the volume (cm3) of the device.", "The energy density (Whcm−3) and power density (Wcm−3) derived from the charge/discharge curves are calculated by the following equations: E = C v × Δ   V 2 2 × 3600 P = Δ   V 2 4 · R ESR · V For the calculation of maximum power density, RESR (equivalent series resistance) of the device was obtained from the EIS (Electrochemical impedance spectroscopy) measurements.", "INCORPORATION BY REFERENCE All of the patents, patent applications, patent application publications and other publications recited herein are hereby incorporated by reference as if set forth in their entirety.", "The present invention has been described in connection with what are presently considered to be the most practical and preferred embodiments.", "However, the invention has been presented by way of illustration and is not intended to be limited to the disclosed embodiments.", "Accordingly, one of skill in the art will realize that the invention is intended to encompass all modifications and alternative arrangements within the spirit and scope of the invention as set forth in the appended claims." ] ]
Patent_15872768
[ [ "HOCKEY SKILLS TRAINING SYSTEM AND METHOD OF USING THE SAME", "A hockey skills training system comprising a foldable high density polymer game board surface; a pair of nested goals disposed on one side of the shooting surface; a handle attached to the shooting surface; and at least one puck; and at least one puck shooting device." ], [ "1.A playing surface for a hockey skills training system, said playing surface comprising a hard low friction polymer surface; a first goal disposed at one end of said surface, said first goal comprising a semi-rigid arch member extending across the end of said surface; second goal, said second goal disposed across the end of said surface and nested within said first goal.", "2.The apparatus of claim 1, wherein the surface is foldable.", "3.A system for hockey skills training, said system comprising: a high density polymer game board; a pair of nested goals disposed at one end of said surface; removable attached netting attached to each goal; a handle attached to said shooting surface; at least one puck; and at least one puck shooting device.", "4.The system of claim 3, wherein the game board is foldable.", "5.A method of playing a hockey skills training game, said method comprising the steps of: providing a pair of game boards; placing each one of said game boards a predetermined distance apart from one another; placing a plurality of pucks on one game board; providing a pair of teams, each team comprising at least one player; placing a team at each board; alternating turns between each team to allow at least one member of each team to shoot at least one puck towards the opposing net on said opposing board; and keeping track of the number of successful attempts by each team." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>In one exemplary embodiment, the present invention comprises a hockey skills training system, said system comprising a hard low friction polymer surface; a net frame disposed at one end of said surface, said net frame comprising a semi-rigid arch member extending across the end of said surface; a second net frame, said second net frame disposed across the end of said surface within said first net frame netting disposed over said first net frame and said second net frame a handle attached to said high density surface.", "In another exemplary embodiment, the present invention comprises a hockey skills training, said system comprising: a high density polymer shooting surface; a pair of nested goals disposed at one end of said surface; removable attached netting attached to each goal; a handle attached to said shooting surface; at least one puck; and at least one puck shooting device.", "In another exemplary embodiment, the present invention comprises a method of playing a hockey skills training game said method comprising the steps of providing a pair of game boards; placing each one of said game boards a predetermined distance apart from one another; placing a plurality of pucks on one game board; providing a pair of teams, each team comprising at least one player; placing a team at each board; alternating turns between each team to allow at least one member of each team to shoot at least one puck towards the opposing net on said opposing board; and keeping track of the number of successful attempts by each team." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS The present non-provisional application claims priority to provisional patent application 62/126,060, filed Feb. 27, 2015.BACKGROUND 1.Field of the Art The present invention relates generally to athletic training devices and methods.", "More specifically, the present invention relates to a physical game and method of playing the game whereby athletic, specifically hockey, skills are developed.", "2.Description of the Prior Art The ability to pass a hockey puck to another player so that it flies through the air like a frisbie over opposing players while still landing flat on the ice for a teammate to control is a very useful hockey skill.", "This type of pass is usually executed when a defensive player tries to get his/her stick in between an offensive player with the puck and the offensive player's teammate across ice.", "To execute this type of pass, a player “opens” the blade of his/her hockey stick (like a golf wedge) so that the puck is positioned at the heel of the blade.", "With a very slight wrist action, the puck is swept across the blade to drive the puck into the air.", "Developing a good pass technique requires a lot of practice, and the present invention is a useful aid in developing this skill.", "SUMMARY In one exemplary embodiment, the present invention comprises a hockey skills training system, said system comprising a hard low friction polymer surface; a net frame disposed at one end of said surface, said net frame comprising a semi-rigid arch member extending across the end of said surface; a second net frame, said second net frame disposed across the end of said surface within said first net frame netting disposed over said first net frame and said second net frame a handle attached to said high density surface.", "In another exemplary embodiment, the present invention comprises a hockey skills training, said system comprising: a high density polymer shooting surface; a pair of nested goals disposed at one end of said surface; removable attached netting attached to each goal; a handle attached to said shooting surface; at least one puck; and at least one puck shooting device.", "In another exemplary embodiment, the present invention comprises a method of playing a hockey skills training game said method comprising the steps of providing a pair of game boards; placing each one of said game boards a predetermined distance apart from one another; placing a plurality of pucks on one game board; providing a pair of teams, each team comprising at least one player; placing a team at each board; alternating turns between each team to allow at least one member of each team to shoot at least one puck towards the opposing net on said opposing board; and keeping track of the number of successful attempts by each team.", "BRIEF DESCRIPTION OF THE DRAWINGS The present invention will be understood more fully from the detailed description given hereinafter and from the accompanying drawings of the preferred embodiment of the present invention, which, however, should not be taken to limit the invention, but are for explanation and understanding only.", "In the drawings: FIG.", "1 shows a perspective view of a system in accordance with the present invention.", "FIG.", "2 shows a perspective view of a system arranged to perform the method of the present invention.", "FIG.", "3 shows an embodiment of game pieces for use with the present invention.", "FIG.", "4 shows an embodiment of the system of the present invention adapted for transport.", "FIG.", "5 shows a cross-sectional view of the embodiment shown in FIG.", "4.FIG.", "6 shows a diagram of a method of using the present invention.", "DETAILED DESCRIPTION OF THE EMBODIMENTS The present invention will be discussed hereinafter in detail in terms of various exemplary embodiments according to the present invention with reference to the accompanying drawings.", "In the following detailed description, numerous specific details are set forth in order to provide a thorough understanding of the present invention.", "It will be obvious, however, to those skilled in the art that the present invention may be practiced without these specific details.", "In other instances, well-known structures are not shown in detail in order to avoid unnecessary obscuring of the present invention.", "Thus, all of the implementations described below are exemplary implementations provided to enable persons skilled in the art to make or use the embodiments of the disclosure and are not intended to limit the scope of the disclosure, which is defined by the claims.", "As used herein, the word “exemplary” or “illustrative” means “serving as an example, instance, or illustration.” Any implementation described herein as “exemplary” or “illustrative” is not necessarily to be construed as preferred or advantageous over other implementations.", "Moreover, in the present description, the terms “upper”, “lower”, “left”, “rear”, “right”, “front”, “vertical”, “horizontal”, and derivatives thereof shall relate to the invention as oriented in FIG.", "1.Furthermore, there is no intention to be bound by any expressed or implied theory presented in the preceding technical field, background, brief summary or the following detailed description.", "It is also to be understood that the specific devices and processes illustrated in the attached drawings, and described in the following specification, are simply exemplary embodiments of the inventive concepts defined in the appended claims.", "Hence, specific dimensions and other physical characteristics relating to the embodiments disclosed herein are not to be considered as limiting, unless the claims expressly state otherwise.", "Referring first to FIG.", "1, hockey skills training system 1000 comprises of at least one playing surface/game board 100.Each board 100 is preferably 24″×42″ with machined sockets for placement of nested goals 200 and 300 at one end.", "Both goals 200 and 300 are made of steel and covered with marine grade vinyl trim encapsulating ¾″ high tenacity polypropelene (“HTPP”) square industrial grade netting.", "Board 100 comprises a hard low friction surface such as high density polyethlene (“HDPE”) surface attached with 30 zinc plated countersunk screws to an extruded aluminum channel frame with HDPE plastic gussets in each corner.", "The aluminum channel has an annodized finish to protect the unit from rusting.", "Large goal 200 is 23½ wide by 12″ high and is disposed at one end of board 100.The small goal 300 is 5″ high by 9″ wide and is nested within large goal 200.Goals 200 and 300 are fixedly attached to one end of board 100.The posts of goals 200 and 300 are made of steel and the netting is an industrial grade ¾″ high tenacity polypropylene (“HTPP”) knotless net.", "The design of each goal is such that one simply picks up the back of each net to retrieve pucks for each turn.", "Steel piping holds the netting snug to the ground containing even hard passes.", "Small net 300 is designed to create a pocket for high scoring shots within the game.", "Each goal 200 and 300 fits onto the board at one end, and the netting is attached via velcro to the frame to create a pocket.", "The posts for each goal 200 and 300 are made of steel, and the netting is an industrial grade ¾″ HTPP knotless net.", "Pucks 400 may comprise a soft vinyl puck.", "Standard a harder puck can be used.", "In one exemplary embodiment, hockey skills training system 1000 comprises two boards 100 with goals 200 and 300 handle 500, and pucks 400 (FIG.", "3).", "In one exemplary embodiment, a first board 100 is used as a “shooting pad.” Board 100 comprises a plastic shooting surface preferably made of a High Grade High Density Polyethylene (“HDPE”).", "The method of the present invention comprises arranging two boards 100 preferably 24 feet apart as shown in FIG.", "2.The distance is measured from the front of one board 100 to the front of another board 100.Those of ordinary skill in the art will appreciate that other distances may be used.", "A game is played preferably with two teams.", "Each team preferably comprises two players with three pucks 400 of a distinguished color for each team.", "One player from each team takes position on opposing boards 100 and all pucks 400 are started from one side.", "Referring now to FIG.", "6, the foul line is defined as the front of the board.", "A player shall not cross the foul line before the puck is released.", "Violation will result in no points for the foul puck, and the puck is to be removed from play before any more pucks are sauced.", "Pucks already on the board that have been knocked off the board by a foul puck will be returned to the same location on the board.", "Additionally, pucks that are on the board, but are knocked into the net by a foul puck must be returned to their original location on the board.", "Pucks that bounce off the ground and come to rest on the board or in the net, do not count, and shall be removed from play before any more pucks are sauced.", "Again, if other pucks are contacted, the same rules as above apply.", "Pucks that come to rest on the board, but are hanging over the board and touching the ground or grass, do not count, and shall be removed from play before any more pucks are passed.", "The team listed on top in the tournament bracket shall begin play first.", "Each player throws all four pucks by alternating tosses with the opposing player.", "The round is complete after all eight pucks are “sauced.” The points are awarded as follows: 3 points for each puck made in the small net.", "1 point for each puck made in the large net.", "A puck must go completely in the net to count for 3 points.", "Any puck(s) that is partially in the net and partially on the board counts as 1 point.", "The score for each round is determined by each team combining their points for all pucks in the net with all pucks on the board.", "The team with the higher total subtracts the opposing team's points and earns the points of the difference between the two totals.", "The team with the lower total does not earn any points for the round.", "The team that scores more points for the round goes first in the next round.", "If there is a tie, the team that went first in the previous round shall go first in the next round.", "No movements or actions that cause distractions to opposing players are allowed.", "A tournament official shall resolve any discrepancies or rulings that cannot be resolved mutually between two teams.", "The winner is declared once a team reaches or exceeds 21 points after the completion of a round.", "The boards of the present invention work best on a flat surface.", "Make sure each board is stable and not rocking during play.", "It is best if each board is kept dry, clean, with minimum exposure to UV.", "Each board 100 is preferably foldable for convenience transport as shown in FIGS.", "4 and 5.The above-described embodiments are merely exemplary illustrations set forth for a clear understanding of the principles of the invention.", "Many variations, combinations, modifications, or equivalents may be substituted for elements thereof without departing from the scope of the invention.", "It should be understood, therefore, that the above description is of an exemplary embodiment of the invention and included for illustrative purposes only.", "The description of the exemplary embodiment is not meant to be limiting of the invention.", "A person of ordinary skill in the field of the invention or the relevant technical art will understand that variations of the invention are included within the scope of the claims." ] ]
Patent_15872778
[ [ "REGIONAL OXIMETRY SLEEVE FOR MOBILE DEVICE", "A system includes a mobile computing device, a sleeve, a contact surface, a sensor module, and a telemetry module.", "The mobile computing device has a first processor within a housing.", "The sleeve has an internal surface configured to fit the housing.", "The contact surface is disposed on an external surface of the sleeve.", "The sensor module is coupled to the contact surface and is configured to generate an electrical signal corresponding to a measured physiological parameter associated with tissue at the contact surface.", "The telemetry module is coupled to the sensor module and is configured to communicate data corresponding to the electrical signal to the mobile computing device." ], [ "1.A method comprising: pairing a first communication module of a mobile computing device with a second communication module of a sleeve, the mobile computing device configured to fit an internal surface of the sleeve, the sleeve having a sleeve processor coupled to a sleeve memory and the sleeve having a contact surface; executing instructions using the sleeve processor, the instructions stored on the sleeve memory, the instructions configured to generate a measured signal using an optical sensor coupled to the contact surface, the measured signal corresponding to a tissue at the contact surface; communicating the measured signal from the sleeve to the mobile computing device using the first communication module and using the second communication module; and executing instructions using the device processor to generate display data for a display of the mobile computing device.", "2.The method of claim 1 wherein executing the instructions using the sleeve processor includes calculating a temperature using a temperature transducer.", "3.The method of claim 1 wherein executing the instructions using the sleeve processor includes emitting light from the optical sensor.", "4.The method of claim 1 wherein executing instructions using the sleeve processor includes calculating regional oximetry.", "5.The method of claim 1 further including displaying regional oximetry data based on the display data using the display." ], [ "<SOH> BACKGROUND <EOH>A measure of regional oximetry can provide an indication as to tissue health.", "Existing technology for measuring regional oximetry is inadequate.", "One example includes an optical sensor coupled by a wire to a separate processing module.", "The sensor may be secured to the patient by an adhesive or by a strap encircling the patient and is tethered by wire to the processing module.", "This arrangement of a sensor and a processor module with a connecting wire is unsatisfactory for certain applications.", "For example, in an emergency situation or a battlefield environment, the separate nature of the modules and the connecting wire can be inconvenient and may be prone to failure." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>In the drawings, which are not necessarily drawn to scale, like numerals may describe similar components in different views.", "Like numerals having different letter suffixes may represent different instances of similar components.", "The drawings illustrate generally, by way of example, but not by way of limitation, various embodiments discussed in the present document.", "FIG.", "1A illustrates a view of a sleeve and mobile computing device, according to one example.", "FIG.", "1B illustrates a view of a sleeve, according to one example.", "FIG.", "2 illustrates a view of a sleeve with tissue, according to one example.", "FIG.", "3 illustrates a block diagram of a system, according to one example.", "FIG.", "4 illustrates a flow chart of a system, according to one example.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CLAIM OF PRIORITY This application is a divisional of and claims the benefit of priority under 35 U.S.C.", "§ 120 to U.S. patent application Ser.", "No.", "14/082,950, filed on Nov. 18, 2013, which is hereby incorporated by reference herein in its entirety.", "BACKGROUND A measure of regional oximetry can provide an indication as to tissue health.", "Existing technology for measuring regional oximetry is inadequate.", "One example includes an optical sensor coupled by a wire to a separate processing module.", "The sensor may be secured to the patient by an adhesive or by a strap encircling the patient and is tethered by wire to the processing module.", "This arrangement of a sensor and a processor module with a connecting wire is unsatisfactory for certain applications.", "For example, in an emergency situation or a battlefield environment, the separate nature of the modules and the connecting wire can be inconvenient and may be prone to failure.", "OVERVIEW The present inventors have recognized, among other things, that a problem to be solved can include providing a system for measuring regional oximetry based on a rapidly established temporary coupling to the tissue and using a mobile computing device.", "The present subject matter can help provide a solution to this problem, such as by a system including a sensor module that can be coupled to a mobile device and manually positioned at a tissue site.", "The mobile device can display results and can communicate the data to a remote device using wireless communication.", "This overview is intended to provide an overview of subject matter of the present patent application.", "It is not intended to provide an exclusive or exhaustive explanation of the invention.", "The detailed description is included to provide further information about the present patent application.", "BRIEF DESCRIPTION OF THE DRAWINGS In the drawings, which are not necessarily drawn to scale, like numerals may describe similar components in different views.", "Like numerals having different letter suffixes may represent different instances of similar components.", "The drawings illustrate generally, by way of example, but not by way of limitation, various embodiments discussed in the present document.", "FIG.", "1A illustrates a view of a sleeve and mobile computing device, according to one example.", "FIG.", "1B illustrates a view of a sleeve, according to one example.", "FIG.", "2 illustrates a view of a sleeve with tissue, according to one example.", "FIG.", "3 illustrates a block diagram of a system, according to one example.", "FIG.", "4 illustrates a flow chart of a system, according to one example.", "DETAILED DESCRIPTION FIG.", "1A illustrates a view of system 100A.", "including sleeve 120A and mobile computing device 50A, according to one example.", "Mobile computing device 50A includes user interface 60A, here shown as a touch-screen configured for displaying data and for receiving user input.", "Mobile computing device 50A includes housing 55A having an outer dimension that can be characterized as a length, a width, or a thickness.", "Mobile computing device 50A can include a cellular telephone (such as a smart-phone), a mini computer, or a tablet computer.", "Sleeve 120A has inner surface 122A configured to receive housing 55A.", "Sleeve 120A can include a rubber molded component or a plastic component having an inner surface configured to securely couple with mobile computing device 50A and to provide physical protection to mobile computing device 50A.", "FIG.", "1B illustrates a view of sleeve 120B, according to one example.", "Sleeve 120B includes inner surface 122B configured to mate with an external dimension of a mobile computing device.", "Sleeve 120B includes contact surface 130A.", "Contact surface 130A has a sensor module including emitter 138A and emitter 138B.", "Emitter 138A emits light that is received by detector 136A along short pathway 140A and light that is received by detector 136B along long pathway 142B.", "Emitter 138B emits light that is received by detector 136B along short pathway 140B and light that is received by detector 136A along long pathway 142A, Light received by detector 136A and detector 136B, using the combination of long pathway 142A, long pathway 142B, short pathway 140A, and short pathway 140B can be processed to generate a measure of regional oximetry (also called tissue oximetry).", "In one example, the calculation entails addition and subtraction of attenuations as detected by detector 136A and detector 136B.", "Detector 136A and detector 136B can include an optical transducer that provides an electrical signal corresponding to detected light.", "The arrangement of optical elements (such as emitter 138A, emitter 138B, detector 136A, and detector 136B) and the number of optical elements (or transducers) can be configured for a particular purpose.", "In one example, contact surface 130A is arranged such that emitter 138A and emitter 138B are at opposing ends and detector 136A and detector 136B are located there between.", "FIG.", "2 illustrates a view of sleeve 120C with tissue 20, according to one example.", "Sleeve 120C includes an inner surface 122C configured to receive a mobile computing device.", "Sleeve 120C includes contact surface 130B.", "Contact surface 130B includes a sensor module configured to generate data as to tissue 20 in contact with contact surface 130B.", "In the example illustrated, tissue 20 is urged against contact surface 130B with sufficient force, as shown at arrows A, to deflect a complaint surface of contact surface 130B.", "As shown, contact surface 130B has a profile as indicated at 70 at a time before tissue 20 is urged into contact surface 130B.", "Strap 40 is affixed to sleeve 120C and encircles a portion of tissue 20, here shown as a section view of a limb (such as an arm or a leg).", "Strap 40, in one example includes a band or strap to retain tissue 20 and contact surface 130B in close proximity.", "In one example, contact surface 130B has a pre-formed contour that conforms to tissue 20.FIG.", "3 illustrates a block diagram of system 100B, according to one example.", "System 100B includes sleeve 120D and mobile computing device 50B.", "Sleeve 120D includes sensor module 134, processor 310, memory 315, telemetry module 320, and power supply 305.Power supply 305 can include a battery and circuitry for regulating power or for charging a battery.", "In one example, power 305 derives electrical energy from a wired coupling with power supply 355 of mobile computing device 50B, as shown by link 390.Power supply 305 is coupled to sensor module 134, processor 310, and telemetry module 320.Sensor module 134 can include a one or more optical detectors (such as detector 136A or detector 136B), one or more optical emitters (such as emitter 138A and emitter 138B), a temperature sensor, a pressure sensor, or an accelerometer.", "In various examples, a sensor can be referred to as a transducer.", "Processor 310, along with measured data from sensor module 134, can provide a variety of blood and tissue measurements.", "For example, a suitable algorithm and a sensor can be configured to provide data as to the following parameters or conditions: Regional saturation (rSO2) Hemoglobin (Hb) concentration in tissue Tissue temperature SpO2 Total hemoglobin (tHb) Hematocrit Anemia CO2 COHb MetHb pH Respiration Perfusion Apnea Pulse wave velocity Blood pressure Interstitial pressure Arterial stiffness Intracranial Pressure Intrauterine pressure/contractions Glucose Cardiac output Bilirubin Hydration Hematoma Vascular compliance Tissue viability Malaria Blood cancer Thrombocytopenia (low platelet count) Sepsis Thrombosis Compartment syndrome In addition, a suitable algorithm and sensor module can provide data as to a material property of an object or as to a surface.", "This can include processing based on data corresponding to an optical measurement, a mechanical measurement, an acoustic measurement, or an electrical measurement.", "For example, data can correspond to an event counter, an event marker (time mark), a density measurement, a conductivity measurement, a concentration measurement, a color measurement, or a light level measurement.", "Processor 310 can include a digital processor or an analog processor circuit.", "In one example, processor 310 includes a microprocessor.", "In the example shown, processor 310 is coupled to memory 315 and processor 310 is configured to execute instructions to implement an algorithm as described elsewhere in this document.", "In one example, memory 315 is configured to store data generated by sensor module 134 or configured to store calibration information for sensor module 134.Processor 310 is coupled to telemetry module 320.In one example, telemetry module 320 includes a wired connection with a corresponding telemetry module 360 of mobile computing device 50B, as shown at link 380.In one example, telemetry module 320 communicates with telemetry module 360 by a wireless channel, as depicted by antenna 325 and antenna 365, shown at link 370.In one example, link 370 includes a radio frequency communication channel, one example of which is known commonly as Bluetooth.", "In other examples, link 370 includes an infrared communication channel, a near-field inductive coupling, or an ultrasonic (or acoustic) coupling.", "Mobile computing device 50B includes I/O module 60B coupled to telephone module 330.I/O module 60B can include a touch-sensitive screen configured to receive user-entered data or keystrokes and configured to display visual data.", "Telephone module 330 can include a cellular telephone module, a text message module, or other wireless communication module.", "Telephone module 330 can allow data exchange with a cloud-based server or storage facility.", "Telephone module 330 is coupled to processor 340.Processor 340 is coupled to memory 345 and coupled to telemetry module 360.Mobile computing device 50B includes power 355 coupled to telephone module 330, processor 340, and telemetry module 360.FIG.", "4 illustrates flow chart 400 implemented by a system, according to one example.", "Flow chart 400 includes, at 410, pairing communication modules.", "In one example, this entails establishing a wireless link between telemetry module 320 (and using antenna 325) and telemetry module 360 (and using antenna 365) in a process known as pairing.", "Pairing can include exchanging access credentials and coordinating handshaking protocols, Some communication protocols, such as Bluetooth, are paired by executing a predetermined algorithm.", "At 420, method 400 includes executing instructions to generate a measured signal using sensor module 134.This can include executing instructions (stored in memory 315) using processor 310 to implement an algorithm.", "The algorithm can entail operating an emitter (such as emitter 138A or emitter 138B) according to a particular protocol and receiving an output signal from a detector (such as detector 136A or detector 136B).", "In one example, this can include receiving a temperature signal from a temperature transducer.", "At 430, method 400 includes communicating the measured signal to the mobile computing device.", "Communicating can include sending and receiving a wireless signal (using wireless telemetry modules) or can include communicating using a wired connection between the sleeve and the mobile computing device.", "At 440, method 400 includes executing instructions using processor 340 to generate a visible display of data.", "The data can be displayed on user interface 60A or on I/O module 60B.", "Various Notes & Examples Example 1 can include a system having a mobile computing device, a sleeve, a contact surface, a sensor module, and a telemetry module.", "The mobile computing device can include a first processor within a housing.", "The sleeve can include an internal surface configured to fit the housing.", "The contact surface can include an external surface of the sleeve.", "The sensor module is coupled to the contact surface and can be configured to generate an electrical signal corresponding to a measured physiological parameter associated with tissue at the contact surface.", "The telemetry module can be coupled to the sensor module and configured to communicate data corresponding to the electrical signal to the mobile computing device.", "Example 2 can include, or can optionally be combined with the subject matter of Example 1 to optionally include wherein the mobile computing device includes a smart telephone.", "Example 3 can include, or can optionally be combined with the subject matter of Example 1 to optionally include wherein the contact surface includes a compliant member, the compliant member configured to conform to a tissue contour.", "Example 4 can include, or can optionally be combined with the subject matter of Example 1 to optionally include wherein the contact surface has a curved contour.", "Example 5 can include, or can optionally be combined with the subject matter of Example 1 to optionally include wherein the contact surface includes a non-stick surface.", "Example 6 can include, or can optionally be combined with the subject matter of Example 1 to optionally include wherein the electrical signal corresponds to regional oximetry.", "Example 7 can include, or can optionally be combined with the subject matter of Example 1 to optionally include wherein the sensor module includes at least two optical detectors and wherein the electrical signal is determined by a combination of the at least two optical detectors.", "Example 8 can include, or can optionally be combined with the subject matter of Example 1 to optionally include wherein the sensor module is coupled to a battery.", "Example 9 can include, or can optionally be combined with the subject matter of Example 1 to optionally include a second processor coupled to the sensor module, the second processor configured to generate the data.", "Example 10 can include, or can optionally be combined with the subject matter of Example 1 to optionally include wherein the telemetry module includes a wireless transceiver.", "Example 11 can include, or can optionally be combined with the subject matter of Example 1 to optionally include wherein the mobile computing device is configured to execute instructions to communicate with a remote device.", "Example 12 can include, or can optionally be combined with the subject matter of Example 1 to optionally include wherein the mobile computing device is configured to execute instructions to communicate with a remote device in near real-time.", "Example 13 can include, or can optionally be combined with the subject matter of Example 1 to optionally include wherein the housing includes a retention strap.", "Example 14 can include a device having a sleeve, a contact surface, a sensor module, and a telemetry module.", "The sleeve can have an internal surface configured to fit an external dimension of a mobile computing device.", "The contact surface is on an external surface of the sleeve.", "The sensor module is coupled to the contact surface and configured to generate an electrical signal corresponding to a measured physiological parameter associated with tissue at the contact surface.", "The telemetry module is coupled to the sensor module and configured to communicate data corresponding to the electrical signal to the mobile computing device.", "Example 15 can include, or can optionally be combined with the subject matter of Example 14 to optionally include wherein the sleeve includes a rubber housing.", "Example 16 can include, or can optionally be combined with the subject matter of Example 14 to optionally include wherein the electrical signal corresponds to regional oximetry.", "Example 17 can include, or can optionally be combined with the subject matter of Example 14 to optionally include wherein the telemetry module includes a radio frequency transceiver.", "Example 18 can include, or can optionally be combined with the subject matter of Example 14 to optionally include a battery coupled to at least one of the sensor module and the telemetry module.", "Example 19 can include, or can optionally be combined with the subject matter of Example 14 to optionally include wherein the sensor module includes at least two optical detectors.", "Example 20 can include a method including pairing a first communication module of a mobile computing device with a second communication module of a sleeve.", "The mobile computing device is configured to fit an internal surface of the sleeve.", "The sleeve has a sleeve processor coupled to a sleeve memory and the sleeve has a contact surface.", "The method includes executing instructions using the sleeve processor.", "The instructions are stored on the sleeve memory.", "The instructions are configured to generate a measured signal using an optical sensor coupled to the contact surface.", "The measured signal corresponds to a tissue at the contact surface, The method includes communicating the measured signal from the sleeve to the mobile computing device using the first communication module and using the second communication module.", "The method includes executing instructions using the device processor to generate display data for a display of the mobile computing device.", "Example 21 can include, or can optionally be combined with the subject matter of Example 20 to optionally include wherein executing the instructions using the sleeve processor includes calculating a temperature using a temperature transducer.", "Example 22 can include, or can optionally be combined with the subject matter of Example 20 to optionally include wherein executing the instructions using the sleeve processor includes emitting light from the optical sensor.", "Example 23 can include, or can optionally be combined with the subject matter of Example 20 to optionally include wherein executing the instructions using the sleeve processor includes calculating regional oximetry.", "Example 24 can include, or can optionally be combined with the subject matter of Example 20 to optionally include displaying regional oximetry data based on the display data using the display.", "Each of these non-limiting examples can stand on its own, or can be combined in various permutations or combinations with one or more of the other examples.", "The above detailed description includes references to the accompanying drawings, which form a part of the detailed description.", "The drawings show, by way of illustration, specific embodiments in which the invention can be practiced.", "These embodiments are also referred to herein as “examples.” Such examples can include elements in addition to those shown or described.", "However, the present inventors also contemplate examples in which only those elements shown or described are provided.", "Moreover, the present inventors also contemplate examples using any combination or permutation of those elements shown or described (or one or more aspects thereof), either with respect to a particular example (or one or more aspects thereof), or with respect to other examples (or one or more aspects thereof) shown or described herein.", "In the event of inconsistent usages between this document and any documents so incorporated by reference, the usage in this document controls.", "In this document, the terms “a” or “an” are used, as is common in patent documents, to include one or more than one, independent of any other instances or usages of “at least one” or “one or more.” in this document, the term “or” is used to refer to a nonexclusive or, such that “A or B” includes “A but not B,” “B but not A,” and “A and B,” unless otherwise indicated.", "In this document, the terms “including” and “in which” are used as the plain-English equivalents of the respective terms “comprising” and “wherein.” Also, in the following claims, the terms “including” and “comprising” are open-ended, that is, a system, device, article, composition, formulation, or process that includes elements in addition to those listed after such a term in a claim are still deemed to fall within the scope of that claim.", "Moreover, in the following claims, the terms “first,” “second,” and “third,” etc.", "are used merely as labels, and are not intended to impose numerical requirements on their objects.", "Method examples described herein can be machine or computer-implemented at least in part.", "Some examples can include a computer-readable medium or machine-readable medium encoded with instructions operable to configure an electronic device to perform methods as described in the above examples.", "An implementation of such methods can include code, such as microcode, assembly language code, a higher-level language code, or the like.", "Such code can include computer readable instructions for performing various methods.", "The code may form portions of computer program products.", "Further, in an example, the code can be tangibly stored on one or more volatile, non-transitory, or non-volatile tangible computer-readable media, such as during execution or at other times.", "Examples of these tangible computer-readable media can include, but are not limited to, hard disks, removable magnetic disks, removable optical disks (e.g., compact disks and digital video disks), magnetic cassettes, memory cards or sticks, random access memories (RAMS), read only memories (ROMs), and the like.", "The above description is intended to be illustrative, and not restrictive.", "For example, the above-described examples (or one or more aspects thereof) may be used in combination with each other.", "Other embodiments can be used, such as by one of ordinary skill in the art upon reviewing the above description.", "The Abstract is provided to comply with 37 CFR.", "§ 1.72(b), to allow the reader to quickly ascertain the nature of the technical disclosure.", "It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.", "Also, in the above Detailed Description, various features may be grouped together to streamline the disclosure.", "This should not be interpreted as intending that an unclaimed disclosed feature is essential to any claim.", "Rather, inventive subject matter may lie in less than all features of a particular disclosed embodiment.", "Thus, the following claims are hereby incorporated into the Detailed Description as examples or embodiments, with each claim standing on its own as a separate embodiment, and it is contemplated that such embodiments can be combined with each other in various combinations or permutations.", "The scope of the invention should be determined with reference to the appended claims, along with the full scope of equivalents to which such claims are entitled." ] ]
Patent_15872779
[ [ "DRIVING SUPPORT APPARATUS FOR A VEHICLE", "A driving support apparatus for a vehicle is provided.", "The apparatus causes an alarm unit to issue an alarm based on a lane marking of an own lane in which an own vehicle runs.", "The apparatus includes a leading vehicle detection section that determines a leading vehicle running in the own lane, a crossing over determination section that determines whether or not the leading vehicle has crossed over the lane marking present at an opposite side of the target, when a target is present at a left side or a right side of the leading vehicle in the own lane, and an alarm inhibition section that inhibits the alarm based on a result of the determination whether or not the leading vehicle has crossed over the lane marking present at the opposite side of the target." ], [ "1.A driving support apparatus for a vehicle, the apparatus causing an alarm unit to issue an alarm based on a lane marking of an own lane in which an own vehicle runs and comprising: an allowance determination section that determines whether or not the own vehicle is allowed to cross over the lane marking, and an alarm inhibition section that inhibits the alarm when the allowance determination section determines that the own vehicle is allowed to cross over the lane marking.", "2.The driving support apparatus according to claim 1, wherein the allowance determination section determines whether or not the own vehicle is allowed to cross over the lane marking, based on an obstacle present ahead of the own vehicle or a situation of a leading vehicle.", "3.The driving support apparatus according to claim 1, wherein the lane marking includes a virtual lane." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY <EOH>An embodiment provides a driving support apparatus for a vehicle, the apparatus being able to appropriately cause an alarm to be issued which indicates that an own vehicle has crossed over a lane marking.", "As an aspect of the embodiment, a driving support apparatus for a vehicle is provided.", "The apparatus causes an alarm unit to issue an alarm based on a lane marking of an own lane in which an own vehicle runs.", "The apparatus includes: a leading vehicle detection section that determines a leading vehicle running in the own lane; a crossing over determination section that determines whether or not the leading vehicle has crossed over the lane marking present at an opposite side of the target, when a target is present at a left side or a right side of the leading vehicle in the own lane; and an alarm inhibition section that inhibits the alarm based on a result of the determination whether or not the leading vehicle has crossed over the lane marking present at the opposite side of the target." ], [ "CROSS-REFERENCE TO RELATED APPLICATION This application is based on and claims the benefit of priority from earlier Japanese Patent Application No.", "2015-219820 filed Nov. 9, 2015, the description of which is incorporated herein by reference.", "BACKGROUND Technical Field The present invention relates to a driving support apparatus for a vehicle.", "Related Art Conventionally, various driving support techniques have been proposed which are for supporting driving of the driver of a vehicle.", "For example, a technique is known in which when an own vehicle has deviated from a driving lane, an alarm is issued to the driver of the own vehicle (e.g.", "refer to JP-A-2008-117054).", "However, in the above conventional technique, it can be considered that deviation of the own vehicle from the traveling lane is allowed in some surrounding environments in which, for example, there are stopped or parked vehicles, persons, structures, or the like at the edge of the lane in which the own vehicle runs.", "In this case, it can be considered that an alarm indicating that the own vehicle has deviated from the traveling lane may be unnecessarily issued though the driver is purposefully making the own vehicle deviate from the driving lane.", "In this regard, if an unnecessary alarm is issued, the driver may feel discomfort.", "Hence, There is room for improvement.", "SUMMARY An embodiment provides a driving support apparatus for a vehicle, the apparatus being able to appropriately cause an alarm to be issued which indicates that an own vehicle has crossed over a lane marking.", "As an aspect of the embodiment, a driving support apparatus for a vehicle is provided.", "The apparatus causes an alarm unit to issue an alarm based on a lane marking of an own lane in which an own vehicle runs.", "The apparatus includes: a leading vehicle detection section that determines a leading vehicle running in the own lane; a crossing over determination section that determines whether or not the leading vehicle has crossed over the lane marking present at an opposite side of the target, when a target is present at a left side or a right side of the leading vehicle in the own lane; and an alarm inhibition section that inhibits the alarm based on a result of the determination whether or not the leading vehicle has crossed over the lane marking present at the opposite side of the target.", "BRIEF DESCRIPTION OF THE DRAWINGS In the accompanying drawings: FIG.", "1 is a drawing showing a configuration of a driving support system; FIG.", "2 is a drawing showing a situation in which a vehicle is allowed to cross over a lane marking; FIG.", "3 is a drawing illustrating a lateral distance H1 and allowance determination; FIG.", "4 is a flowchart illustrating a processing procedure for inhibiting an alarm; FIG.", "5 is a drawing illustrating a lateral distance H2 and allowance determination; and FIG.", "6 is a flowchart illustrating a processing procedure for inhibiting an alarm.", "DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS First Embodiment Hereinafter, an embodiment of a driving support apparatus for a vehicle will be descried with reference to the drawings.", "The driving support apparatus according to the present embodiment is mounted in the vehicle, and performs various driving support processes when the driver drives the vehicle.", "First, the schematic configuration of the driving support system will be described with reference to FIG.", "1.In FIG.", "1, a driving support ECU 10, which is a driving support apparatus, is connected with an imaging unit 21, a radar 22, a yaw rate sensor 23, a steering angle sensor 24, and a vehicle speed sensor 25, from each of which the driving support ECU 10 receives detection signals and various kinds of information.", "The imaging unit 21 is an in-vehicle camera and includes a CCD camera, a CMOS image sensor, a near-infrared camera, or the like.", "The imaging unit 21 acquires images of surrounding environments of the vehicle including a driving lane of the vehicle.", "Then, the imaging unit 21 generates image data representing the acquired images and sequentially outputs the image data to the driving support ECU 10.The imaging unit 21 is disposed, for example, in the vicinity of the upper end of the front windshield of the vehicle, and acquires images of an area extending ahead of the vehicle and in a predetermined angular range centering on the imaging axis thereof.", "Note that the imaging unit 21 may be a monocular camera or a stereo camera.", "The radar 22 transmits an electromagnetic wave as a transmission wave and receives a reflected wave thereof to detect a target, and is configured by a millimeter-wave radar, a laser radar, or the like.", "The radar 22 is mounted on the front part of the vehicle, and scans an area, which extends ahead of the vehicle and over a range of a predetermined angle centering on the optical axis thereof with, a radar signal.", "Then, the radar 22 generates distance measurement data based on the time period between the transmission of an electromagnetic wave ahead of the vehicle and the reception of a reflected wave, and sequentially outputs the generated data to the driving support ECU 10.The distance measurement data includes information on a direction in which an object is present, the distance to the object, and a relative speed.", "The yaw rate sensor 23 has, for example, an oscillator such as a tuning fork, and detects distortion generated in the oscillator based on the yaw moment of the own vehicle to detect a yaw angle of the own vehicle.", "The steering angle sensor 24 detects an operation angle of the steering wheel, that is, a steering angle.", "The vehicle sensor 25 is provided to a rotating shaft transferring power to the wheels of the vehicle, and outputs a detection signal depending on the vehicle speed.", "In addition, the driving support ECU 10 is connected with an alarm unit 31.The alarm unit 31 informs the driver of the fact that a dangerous situation has arisen in the own vehicle, the fact that any prohibited act has been carried out, or the like.", "The alarm unit 31 is, for example, a loudspeaker provided in the vehicle interior.", "When the driving support ECU 10 outputs a control command, the alarm unit 31 gives information to the driver by a sound or the like.", "Note that, instead of the alarm of the alarm unit 31, information may be given to the driver by applying reaction force against vibration and driving operation to the driver from the steering wheel.", "In addition, information may be given to the driver by indication on a display panel such as a display provided to an instrument panel.", "The driving support ECU 10 is a computer including a CPU, a ROM, a RAM, and an I/O.", "The driving support ECU 10 executes a program installed in the ROM to achieve various functions.", "Specifically, as basic operation, the driving support ECU 10 determines whether or not the own vehicle has crossed over a lane marking of the lane in which the own vehicle runs (hereinafter, referred to as own lane).", "If the driving support ECU 10 determines that the own vehicle has crossed over a lane marking, the driving support ECU 10 outputs a control command to the alarm unit 31.Thereby, the alarm unit 31 gives information to the driver.", "In addition, in the present embodiment, even when the own vehicle has crossed over a lane marking of the own lane, issuing an alarm is inhibited if the own vehicle is allowed to cross over the lane marking.", "As a means for inhibiting an alarm, the driving support ECU 10 achieves, in addition to the above functions, functions of a target detection section 11, a leading vehicle detection section 12, a crossing over determination section 13, an allowance determination section 14, and an alarm inhibition section 15.Based on information (image data and distance measurement data) on an object obtained by the imaging unit 21 and the radar 22, the target detection section 11 detects a target included in the data.", "For example, the target detection section 11 combines information on the object extracted from the image data of the imaging unit 21 with information on the object extracted from the distance measurement data of the radar 22 to detect a target.", "Instead of this, a target may be detected by using any one of the information on the object extracted from the image data of the imaging unit 21 and the information on the object extracted from the distance measurement data of the radar 22.The target detected by the target detection section 11 is output to the leading vehicle detection section 12.Based on the target detected by the target detection section 11, the leading vehicle detection section 12 detects a forward vehicle, which is one of the vehicles running ahead of the own vehicle and in the own lane, in which the own vehicle runs, as a leading vehicle on condition that the forward vehicle is closest to the own vehicle (the distance between the own vehicle and the forward vehicle is shorter than the distances between the own vehicle and other vehicles running ahead of the own vehicle and in the own lane).", "In addition to the above, a leading vehicle may be detected by using a lateral distance between a travel path of the forward vehicle and the own vehicle or an own lane probability map.", "In addition, the leading vehicle detection section 12 detects one of the forward vehicles as a leading vehicle on condition that the difference between the width of the own vehicle and the width of the leading vehicle is equal to or less than a threshold value Th1.The crossing over determination section 13 determines whether or not the leading vehicle has crossed over a lane marking of the own lane.", "Specifically, the crossing over determination section 13 recognizes a white line (lane marking) of the own lane based on the imaging result of the imaging unit 21.Then, the crossing over determination section 13 detects an obstacle at the left side or the right side of the leading vehicle in the own lane, and determines whether or not the leading vehicle has crossed over a lane marking present at the opposite side of the obstacle.", "The result of the determination whether or not the leading vehicle has crossed over a lane marking present at the opposite side of the obstacle is output to the alarm inhibition section 15.Note that the lane marking is not limited to a white line but may be a solid line such as a yellow line, or Botts' Dots.", "Furthermore, the lane marking may be a virtual lane obtained based on roadside information on guardrails or the like.", "The allowance determination section 14 determines whether or not the own vehicle is in a situation in which the own vehicle is allowed to cross over a lane marking.", "Specifically, it is determined whether or not the own vehicle is in a situation in which the own vehicle is allowed to run while crossing over a lane marking based on the size of a travel area (available unobstructed travel area) of the own vehicle, the travel area being other than an area of the own lane which is occupied by obstacles.", "The result of the determination whether or not the own vehicle is allowed to cross over a lane marking is output to the alarm inhibition section 15.The alarm inhibition section 15 determines not to cause an alarm to be issued even when the own vehicle has crossed over a lane marking, based on the result of the determination whether or not the leading vehicle has crossed over the lane marking present at the opposite side of the obstacle and the result of the determination whether or not the own vehicle is allowed to cross over the lane marking.", "The inhibition about an alarm will be further described.", "Depending on the surrounding environments of the own vehicle in which, for example, there are obstacles such as stopped or parked vehicles, persons, structures, and the like at the edge of the own lane, it can be considered that the own vehicle may be allowed to cross over a lane marking.", "Referring to FIG.", "2, a specific example will be described in which an own vehicle is allowed to cross over a lane marking.", "In FIG.", "2, an own vehicle M1 and a leading vehicle M2 running ahead of the own vehicle M1 are running in a straight line in an own lane L, and vehicles are present, which are waiting for right turning, at the right side of the leading vehicle M2.In this case, the vehicles waiting for right turning in the own lane L are present as an obstacle B with respect to the leading vehicle M2 and the own vehicle M1 running in a straight line in the own lane L. As shown in FIG.", "2, when the leading vehicle M2 runs in the own lane L and in a travel area R at the left side of the obstacle B, if the travel area R is narrower than the width of the leading vehicle M2, the leading vehicle M2 crosses over a lane marking D opposite to the obstacle B.", "In addition, also when the own vehicle M1 runs in the travel area R following the leading vehicle M2, the own vehicle M1 crosses over the lane marking D. At this time, the alarm unit 31 issues an alarm indicating that the own vehicle M1 has crossed over the lane marking D. In this case, although the driver has purposefully made the own vehicle M1 cross over the lane marking D, an alarm indicating that the own vehicle M1 has crossed over the lane marking D is unnecessarily issued.", "Thus, in the present embodiment, if the crossing over determination section 13 determines that the leading vehicle has crossed over the lane marking opposite to the obstacle, and if the allowance determination section 14 determines that the width of the leading vehicle is smaller than that of the travel area, the alarm inhibition section 15 determines not to cause an alarm to be issued even if the own vehicle crosses over the lane marking.", "The determination whether or not the own vehicle is allowed to cross over a lane marking will be described with reference to FIG.", "3.In FIG.", "3, the own vehicle M1 and the leading vehicle M2 running ahead of the own vehicle M1 are running in the own lane L, and the obstacle B is present right next to the leading vehicle M2.In addition, the lane marking D is present at the left side of the leading vehicle M2.The allowance determination section 14 obtains a lateral distance H1, which is a distance between the lateral position of the lane marking D in the lane width direction and the lateral position of the obstacle B, and the width W of the leading vehicle M2, and determines whether or not the width W of the leading vehicle M2 is larger than the lateral distance H1.Note that the lateral distance H1 and the width W are obtained from the imaging result of the imaging unit 2.If the width W of the leading vehicle M2 is larger than the lateral distance H1, when the leading vehicle M2 runs in the travel area R, the leading vehicle M2 crosses over the lane marking D. In this case, when the own vehicle M1 runs in the travel area R following the leading vehicle M2, it can be considered that the driver of the own vehicle M1 purposefully makes the own vehicle M1 cross over the lane marking D. Hence, when the leading vehicle M2 has crossed over the lane marking D, if it is determined that the width W of the leading vehicle M2 is larger than the lateral distance H1, it is determined that an alarm is not caused to be issued even if the own vehicle M1 crosses over the lane marking D. Next, a processing procedure for inhibiting an alarm performed by the driving support ECU 10 will be described with reference to the flowchart in FIG.", "4.The present process is repeatedly performed by the driving support ECU 10 at predetermined intervals while the vehicle is running.", "First, in steps S11 and S12, the target detection section 11 detects a target so that the leading vehicle detection section 12 detects a leading vehicle based on the target.", "Next, in step S13, the leading vehicle detection section 12 determines whether or not a leading vehicle is detected.", "If Yes in step 13, the present process proceeds to step S14.In S14, if an obstacle is present at the left side or the right side of the leading vehicle in the own lane, the crossing over determination section 13 determines whether or not the leading vehicle has passed over a lane marking present at the opposite side of the obstacle.", "In this case, the crossing over determination section 13 may determine that the leading vehicle has passed over the lane marking present at the opposite side of the obstacle when the leading vehicle has actually passed over the lane marking present at the opposite side of the obstacle.", "If Yes in step S14, the present process proceeds to steps S15 and S16, in which the leading vehicle detection section 12 detects the lateral distance H1 and the width of the leading vehicle.", "Next, in step S17, the allowance determination section 14 determines whether or not the own vehicle is allowed to cross over the lane marking based on the lateral distance H1 and the width of the leading vehicle.", "If YES in step S17, the present process proceeds to step S18.In step S18, even if the own vehicle has crossed over the lane marking when the own vehicle runs in the travel area, the alarm inhibition section 15 determines that an alarm is not caused to be issued.", "Then, the present process is ended.", "According to the present embodiment described above, the following excellent advantageous effects can be obtained.", "In the above configuration, when an obstacle is detected at the right or the left of the leading vehicle, and the leading vehicle has crossed over the lane marking present at the opposite side of the obstacle, issuing an alarm performed when the own vehicle has passed over the lane marking is inhibited.", "In this case, it is determined whether or not an alarm indicating that the own vehicle has crossed over the lane marking is necessary, and even if the own vehicle has crossed over the lane marking, an alarm is not issued if unnecessary.", "Hence, an unnecessary alarm can be inhibited from being issued.", "As a result, an alarm indicating that the own vehicle has crossed over the lane marking can be appropriately issued.", "In the above configuration, it is determined whether or not the own vehicle is allowed to cross over the lane marking based on the size of the travel area.", "If it is determined to be allowed, an alarm is inhibited from being issued.", "In this case, since it is determined whether or not the own vehicle is allowed to cross over the lane marking, and an unnecessary alarm is inhibited from being issued, an unnecessary alarm can be appropriately inhibited from being issued.", "In the above configuration, if the width of the leading vehicle is larger than the lateral distance H1 between the lane marking and the target, it is determined that the own vehicle is allowed to cross over the lane marking.", "In this case, if the width of the leading vehicle is larger than the lateral distance H1, it is determined that the own vehicle crosses over the lane marking when running in the travel area, whereby the own vehicle is allowed to cross over the lane marking.", "Hence, before the own vehicle runs in the travel area, it can be determined whether or not the own vehicle is allowed to cross over the lane marking.", "Second Embodiment Next, the second embodiment will be described.", "In the following description, the configurations similar to those of the above embodiment are denoted by the same reference numerals, and redundant descriptions are appropriately omitted.", "A travel path extending from the center position in the width direction of the leading vehicle may be generated.", "Based on a lateral distance, which is a distance between a position on the travel path (path position) and a lateral position of an obstacle, it may be determined whether or not the own vehicle is allowed to cross over a lane marking.", "In FIG.", "5, a travel path T is generated based on, for example, positions of the leading vehicle obtained at predetermined intervals.", "Then, the allowance determination section 14 obtains a lateral distance H2 between the position of the leading vehicle M2 on the travel path (path position) T of the leading vehicle M2 and the lateral position of the obstacle B, the position being obtained before the leading vehicle M2 reaches the travel area R, and the width W of the leading vehicle M2, and determines whether or not the half of the width W of the leading vehicle M2 is larger than the lateral distance H2.If the half of the width W of the leading vehicle M2 is larger than the lateral distance H2, when the leading vehicle M2 runs in the travel area R, the leading vehicle M2 crosses over the lane marking D to avoid the obstacle B.", "In this case, when the own vehicle M1 runs in the travel area R following the leading vehicle M2, it can be considered that the driver of the own vehicle M1 purposefully makes the own vehicle M1 cross over the lane marking D. Hence, when the leading vehicle M2 has crossed over the lane marking D, if it is determined that the half of the width W of the leading vehicle M2 is larger than the lateral distance H2, it is determined that an alarm should not be caused to be issued even if the own vehicle M1 crosses over the lane marking D. Next, a processing procedure for inhibiting an alarm performed by the driving support ECU 10 will be described with reference to the flowchart in FIG.", "6.The present process is performed instead of the process of FIG.", "4.In FIG.", "6, the same steps as those of FIG.", "4 are denoted by the same step numbers.", "FIG.", "6 differs from FIG.", "4 in that steps S21 to S23 are added.", "In steps S11 to S13, the leading vehicle detection section 12 determines that a leading vehicle is detected.", "Next, in step S21, the leading vehicle detection section 12 obtains a travel path of the leading vehicle.", "In step S14, if the crossing over determination section 13 determines that the leading vehicle has passed over a lane marking, in steps S22 and S16, the leading vehicle detection section 12 obtains the lateral distance H2 and the width of the leading vehicle.", "Next, in step S23, the allowance determination section 14 determines whether or not the own vehicle is allowed to cross over the lane marking based on the lateral distance H2 and the half of the width W. According to the present embodiment described above, the following excellent advantageous effects can be obtained.", "In the above configuration, if the half of the width of the leading vehicle is larger than the lateral distance H2 between the position on the path (path position) and the obstacle, it is determined that the own vehicle is allowed to cross over the lane marking.", "In this case, it can be determined whether or not the own vehicle is allowed to cross over the lane marking based on the positional relationship between the leading vehicle and the obstacle in the lane width direction.", "Other Embodiments The above embodiments may be modified as below.", "Even if the width of the leading vehicle is larger than the lateral distance H1, which is a lateral distance between the lane marking and the obstacle, when the width of the own vehicle is smaller than the width of the leading vehicle, it can be considered that the own vehicle may run in the travel area without crossing over the lane marking.", "In this regard, in the first embodiment, if the width of the leading vehicle is larger than the lateral distance H1, the driving support ECU 10 determines that the own vehicle is not allowed to cross over the lane marking.", "However, this can be modified as below.", "Even if the width of the leading vehicle is larger than the travel area, when the difference obtained by subtracting the width of the own vehicle from the width of the leading vehicle is equal to or more than a threshold value Th2 (Th2>0), the driving support ECU 10 may determine that the own vehicle is not allowed to cross over the lane marking.", "In this case, considering the difference between the width of the leading vehicle and the width of the own vehicle, it can be accurately determined whether or not the own vehicle is allowed to cross over the lane marking.", "In the first embodiment, it is determined whether or not the own vehicle is allowed to cross over the lane marking based on the width of the leading vehicle.", "This may be modified so as to determine whether or not the own vehicle is allowed to cross over the lane marking based on the width of the own vehicle.", "In this case, for example, if the width of the own vehicle is larger than the lateral distance H1 between the lane marking and the obstacle, it may be determined that the own vehicle is allowed to cross over the lane marking.", "Hence, regardless of the width of the leading vehicle, it can be determined whether or not the own vehicle is allowed to cross over the lane marking.", "In addition, instead of using the width of the leading vehicle, a predetermined value may be used.", "In short, it may be determined whether or not the own vehicle is allowed to cross over the lane marking based on the size of the travel area.", "In the second embodiment, a travel path of the leading vehicle is generated to obtain the distance between the travel path and an obstacle as the lateral distance H2 between the position on the path (path position) and the obstacle.", "This may be modified so as to detect a running position of the own vehicle based on the yaw rate sensor 23, the steering angle sensor 24, and the vehicle sensor 25 and generate a travel path of the own vehicle to obtain the distance between the travel path and the obstacle as the lateral distance H2.When an obstacle is moving, the size of the travel area differs between when the leading vehicle passes through the travel area and when the own vehicle passes through the travel area.", "In this regard, it may be determined whether or not the own vehicle is allowed to cross over the lane marking based on the moving speed and the moving direction of the obstacle.", "Thereby, even when the size of the travel area changes as the obstacle moves, it can be determined whether or not the own vehicle is allowed to cross over the lane marking considering the moving speed and the moving direction of the obstacle.", "In the above configuration, the present invention is applied to a vehicle driven by driving operation of the driver.", "However, the present invention may be applied to a vehicle performing follow-up control under which the vehicle follows a leading vehicle based on the running position of the leading vehicle.", "Under this follow-up control, when the leading vehicle has crossed over the lane marking to avoid an obstacle, the own vehicle following the leading vehicle also crosses over the lane marking if the own vehicle is allowed to cross over the lane marking.", "At this time, the alarm inhibition section 15 inhibits an alarm of the own vehicle.", "Although the alarm inhibition section 15 determines that an alarm is not caused to be issued even when the own vehicle has crossed over the lane marking.", "This can be changed so as to change the manner of the alarm to inhibit the alarm from being issued.", "As an aspect of the embodiment, a driving support apparatus for a vehicle is provided.", "The apparatus causes an alarm unit (31) to issue an alarm based on a lane marking of an own lane in which an own vehicle (M1) runs.", "The apparatus includes: a leading vehicle detection section (12) that determines a leading vehicle (M2) running in the own lane; a crossing over determination section (13) that determines whether or not the leading vehicle has crossed over the lane marking present at an opposite side of the target, when a target is present at a left side or a right side of the leading vehicle in the own lane; and an alarm inhibition section (15) that inhibits the alarm based on a result of the determination whether or not the leading vehicle has crossed over the lane marking present at the opposite side of the target.", "If a target such as a stopped vehicle or a structure is present in the lane, a travel area of the own vehicle may narrow.", "In this case, when the own vehicle passes through the travel area, the own vehicle may cross over the lane marking.", "When the own vehicle crosses over the lane marking, an unnecessary alarm may be issued.", "In this regard, when a target is detected at the right or the left of the leading vehicle, and the leading vehicle has crossed over the lane marking present at the opposite side of the target, issuing an alarm performed when the own vehicle has passed over the lane marking is inhibited.", "In this case, it is determined whether or not an alarm indicating that the own vehicle has crossed over the lane marking is necessary, and even if the own vehicle has crossed over the lane marking, an alarm is not issued if unnecessary.", "Hence, an unnecessary alarm can be inhibited from being issued.", "As a result, an alarm indicating that the own vehicle has crossed over the lane marking can be appropriately issued.", "It will be appreciated that the present invention is not limited to the configurations described above, but any and all modifications, variations or equivalents, which may occur to those who are skilled in the art, should be considered to fall within the scope of the present invention." ] ]
Patent_15872780
[ [ "CAPACITY CONTROL VALVE", "A capacity control valve includes: a pressure-sensitive body positioned in a third valve chamber; an adapter provided on the free end of the pressure sensitive body having a circular seating surface; a third valve part that moves integrally with a valve element in the third valve chamber and has a circular engagement surface that opens/closes intake-side passages by engaging with and separating from the seating surface of the adapter; and a solenoid that applies an electromagnetic drive force to the valve element in the direction of closing a first valve part, wherein the pressure-sensitive body is formed by a formed bellows made of material having greater yield stress than phosphor bronze, and the formed bellows has its diameter set smaller and its stroke longer than the diameter and stroke of a phosphor bronze bellows." ], [ "1.A capacity control valve, comprising: discharge-side passages communicating a discharge chamber that discharges fluid and a control chamber that controls a discharge rate of fluid; a first valve chamber formed along the discharge-side passages; intake-side passages communicating an intake chamber that takes in fluid and the control chamber; a second valve chamber formed along the intake-side passages; a valve element that integrally has a first valve part that opens/closes the discharge-side passages in the first valve chamber and a second valve part that opens/closes the intake-side passages in the second valve chamber, where the first and second valve parts open/close in opposite directions due to reciprocating motion; a valve body accommodating the valve element in a manner allowing a reciprocating motion, and cooperating with the valve element to form the first valve chamber and the second valve chamber; a third valve chamber formed along the intake-side passages at a position closer to the control chamber than to the second valve chamber; a pressure-sensitive body positioned in the third valve chamber to apply, by extending, a bias force in a direction of opening the first valve part, and also to contract as a surrounding pressure increases; an adapter provided on a free end of the pressure-sensitive body in extending/contracting direction and having a circular seating surface; a third valve part that moves integrally with the valve element in the third valve chamber and has a circular engagement surface that opens/closes the intake-side passages by engaging with and separating from the seating surface of the adapter; and a solenoid that applies an electromagnetic drive force to the valve element in a direction of closing the first valve part; the capacity control valve characterized in that: the valve element is located between the first valve chamber and the second valve chamber, and has an outer circumferential face part slidably movable relative to an inner circumferential face of the valve body; plural of screw grooves are formed on the outer circumferential face part; each of the plural threads of screw grooves communicates with the first valve chamber and does not communicate with the second valve chamber, when the first valve part is closed, and communicates neither with the first valve chamber nor the second valve chamber, when the first valve part is opened.", "2.A capacity control valve according to claim 1, wherein the plural threads of screw grooves are provided in a position equally spaced in the circumferential direction.", "3.A capacity control valve according to claim 1, wherein at least one end in the side of the first valve chamber of each of the plural threads of screw grooves is an incomplete screw part.", "4.A capacity control valve according to claim 1, wherein each of the plural threads of screw grooves communicates with the first valve chamber, in such a manner that only the incomplete screw part opens to the first valve chamber, when the first valve part is closed." ], [ "<SOH> BACKGROUND ART <EOH>A swashplate type variable-capacity compressor used for an automobile air-conditioning system, etc., comprises, for example, a rotational axis driven by the rotational force of an engine to turn; a swashplate connected to the rotational axis in a manner allowing for change in its inclination angle relative to the rotational axis; and a compression piston connected to the swashplate, wherein the inclination angle of the swashplate is changed to change the stroke of the piston and thereby control the discharge rate of refrigerant gas.", "This inclination angle of the swashplate is continuously changed by utilizing the intake pressure in an intake chamber that takes in refrigerant gas, the discharge pressure in a discharge chamber that discharges refrigerant gas pressurized by the piston, and the control chamber pressure in a control chamber (crank chamber) that houses the swashplate, while also using a capacity control valve driven by electromagnetic force to open/close in order to control the pressure in the control chamber as deemed appropriate, thereby adjusting the balance of pressures acting upon both sides of the piston.", "For such capacity control valve, one comprising the following, for example, is known, as shown in FIG.", "4 (hereinafter referred to as “Prior Art 1”; refer to Patent Literature 1, for example) discharge-side passages 73 , 77 communicating a discharge chamber and control chamber; a first valve chamber 82 formed along the discharge-side passages; intake-side passages 71 , 72 communicating an intake chamber and the control chamber; a second valve chamber (actuation chamber) 83 formed along the intake-side passages; a valve element 81 where a first valve part 76 positioned in the first valve chamber 82 to open/close the discharge-side passages 73 , 77 undergoes reciprocating motion integrally with a second valve part 75 positioned in the second valve chamber 83 to open/close the intake-side passages 71 , 72 , and the two valve parts open/close in opposite directions; a third valve chamber (capacity chamber) 84 formed along the intake-side passages 71 , 72 at a position closer to the control chamber; a pressure-sensitive body (bellows) 78 positioned in the third valve chamber to apply a bias force in the extending (expanding) direction and also to contract as the surrounding pressure increases; a valve seat body (engagement part) 80 provided on the free end of the pressure-sensitive body in the expanding/contracting direction and having a circular seating surface; a third valve part (valve-opening connection part) 79 that moves integrally with the valve element 81 in the third valve chamber 84 and is able to open/close the intake-side passages by engaging with and separating from the valve seat body 80 ; and a solenoid S that applies an electromagnetic drive force to the valve element 81 .", "The capacity control valve 70 is also designed in such a way that, if a need arises during capacity control to change the control chamber pressure on the variable-capacity compressor, the discharge chamber and control chamber can be connected to allow for adjustment of the pressure in the control chamber (control chamber pressure) Pc, without having to provide a clutch mechanism on the compressor.", "Additionally, its constitution is such that, if the control chamber pressure Pc rises while the variable-capacity compressor is stopped, the third valve part (valve-opening connection part) 79 is separated from the valve seat body (engagement part) 80 to open the intake-side passages and thereby communicate the intake chamber and control chamber.", "On the capacity control valve 70 thus constituted, the relational expression of the force of each installed spring that generates a snapping force, and the balancing force generated by the pressure of working fluid that flows in, is given by Pc (Ab−Ar 1 )+Pc (Ar 1 −As)+Pd (As−Ar 2 )+Ps (Ar 2 −Ar 1 )+Ps×Ar 1 =Fb+S 1 −Fsol, based on the constitution shown in FIG.", "4 .", "This relational expression can be organized as Pc (Ab−As)+Pd (As−Ar 2 )+Ps×Ar 2 =Fb+S 1 −Fsol.", "Then, assuming the relationship of pressure-receiving areas including the effective pressure-receiving area Ab of the pressure-sensitive body (bellows) 78 , seal pressure-receiving area As of the first valve part 76 , and pressure-receiving area Ar 2 of the second valve part 75 , to be Ab=As=Ar 2 , the above expression can be rewritten as Ps×Ar 2 =Fb+S 1 −Fsol.", "In other words, by making the effective pressure-receiving area Ab of the pressure-sensitive body (bellows) 78 , seal pressure-receiving area As of the first valve part 76 , and pressure-receiving area Ar 2 of the second valve part 75 identical or roughly identical, the control accuracy of the capacity control valve 1 will improve because only the intake pressure Ps flowing from the intake-side passage 71 acts upon the valve element 81 .", "The symbols in the aforementioned expression are as follows: Ab - - - Effective pressure-receiving area of the pressure-sensitive body (bellows) 78 Ar 1 - - - Pressure-receiving area (cross-section area) of the third valve part 79 As - - - Seal pressure-receiving area of the first valve part 76 Ar 2 - - - Pressure-receiving area of the second valve part 75 Fb - - - Snapping (spring) force of the pressure-sensitive body (bellows) (overall) S 1 - - - Spring (snapping) means 85 Fsol - - - Electromagnetic force of the electromagnetic coil Ps - - - Intake pressure Pd - - - Discharge pressure Pc - - - Control pressure (crank chamber pressure) As described above, to achieve a capacity control valve of good control accuracy, the relationship of pressure-receiving areas including the effective pressure-receiving area Ab of the pressure-sensitive body 78 , seal pressure-receiving area As of the first valve part 76 , and pressure-receiving area Ar 2 of the second valve part 75 , must be Ab=As=Ar 2 , and therefore it can be said that the diameter of the capacity control valve is determined by the diameter of the pressure-sensitive body 78 or diameter of the valve element 81 .", "In Prior Art 1, the pressure-sensitive body 78 hermetically connects one end of a metal bellows 78 A to a partition adjustment part 86 and connects the other end to the valve seat body 80 , and a coil spring 87 is housed in the bellows 78 A.", "This bellows 78 A is made of phosphor bronze to achieve good workability, but from the viewpoint of spring property, phosphor bronze has a small yield stress as a material itself and cannot ensure a long stroke, and also a bellows made of phosphor bronze tends to undergo characteristic changes such as drop in load when an excessive pressure is applied or during use at high temperature, which makes it impossible to reduce the diameter or eliminate the coil spring 87 .", "To reduce the diameter of a phosphor bronze bellows, the thickness of the bellows must be increased and its length also increased in order to ensure long-enough stroke, meaning that a length dimension greater than the overall length of the current bellows is needed, which could result in poor formability and might also cause the bellows to project from the outer diameter dimension of the compressor because the overall length in the axial direction must be extended.", "For these reasons, the diameter of the valve element 81 must be increased in order to ensure the “maximum flow rate (valve full-open flow rate)” which is an important characteristic required of a capacity control valve.", "In other words, producing the bellows 78 A using phosphor bronze makes it impossible to ensure a long stroke and therefore necessitates increasing the diameter of the pressure-sensitive body 78 and that of the valve element 81 , and also in light of the tendency of such bellows to undergo characteristic changes, the coil spring 87 must be included, and consequently the diameter of the capacity control valve increases.", "On the other hand, it is proposed that a control valve of simple structure comprising a pressure-sensitive unit provided in a solenoid unit be obtained by designing the pressure-sensitive unit with a movable end formed on one end of a bellows using strong magnetic material and a fixed end formed on the other end of the bellows using strong magnetic material, and by opposingly positioning the movable end and fixed end inside the bellows with a specified gap provided in between so that the movable end and fixed end form a magnetic circuit for the solenoid unit; wherein such control valve is such that the bellows is formed with stainless material by considering the joining property of the movable end and fixed end formed with strong magnetic material (hereinafter referred to as “Prior Art 2,” refer to Patent Literature 2).", "However, the invention of Prior Art 2 was developed with the object of allowing the components of the pressure-sensitive unit to also function as the components of the solenoid unit because the magnetic circuit for the solenoid unit is formed in the pressure-sensitive unit, thereby simplifying the structure and helping reduce the cost, while also making it easy to assemble the control valve, and furthermore the idea of forming the bellows with stainless material is simply a way to achieve good joining property of the movable end and fixed end formed with strong magnetic material and it does not reduce the diameter of the capacity control valve, and consequently the diameter of the capacity control valve, including the outer diameter of the coil, remains large." ], [ "<SOH> SUMMARY OF INVENTION <EOH>" ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation-in-part of U.S. patent application Ser.", "No.", "14/384,045, filed Sep. 9, 2014, which is the US National Phase under 35 USC § 371 of International Application PCT/JP2013/063501, filed May 15, 2013, which claims priority to Japanese Patent Application No.", "2012-118385, filed May 24, 2012.The International Application was published under.", "PCT Article 21(2) in a language other than English.", "TECHNICAL FIELD The present invention relates to a capacity control valve that variably controls the capacity or pressure of working fluid, and specifically to a capacity control valve that controls the discharge rate of a variable-capacity compressor, etc., used for an automobile air-conditioning system, etc., according to the pressure load.", "BACKGROUND ART A swashplate type variable-capacity compressor used for an automobile air-conditioning system, etc., comprises, for example, a rotational axis driven by the rotational force of an engine to turn; a swashplate connected to the rotational axis in a manner allowing for change in its inclination angle relative to the rotational axis; and a compression piston connected to the swashplate, wherein the inclination angle of the swashplate is changed to change the stroke of the piston and thereby control the discharge rate of refrigerant gas.", "This inclination angle of the swashplate is continuously changed by utilizing the intake pressure in an intake chamber that takes in refrigerant gas, the discharge pressure in a discharge chamber that discharges refrigerant gas pressurized by the piston, and the control chamber pressure in a control chamber (crank chamber) that houses the swashplate, while also using a capacity control valve driven by electromagnetic force to open/close in order to control the pressure in the control chamber as deemed appropriate, thereby adjusting the balance of pressures acting upon both sides of the piston.", "For such capacity control valve, one comprising the following, for example, is known, as shown in FIG.", "4 (hereinafter referred to as “Prior Art 1”; refer to Patent Literature 1, for example) discharge-side passages 73, 77 communicating a discharge chamber and control chamber; a first valve chamber 82 formed along the discharge-side passages; intake-side passages 71, 72 communicating an intake chamber and the control chamber; a second valve chamber (actuation chamber) 83 formed along the intake-side passages; a valve element 81 where a first valve part 76 positioned in the first valve chamber 82 to open/close the discharge-side passages 73, 77 undergoes reciprocating motion integrally with a second valve part 75 positioned in the second valve chamber 83 to open/close the intake-side passages 71, 72, and the two valve parts open/close in opposite directions; a third valve chamber (capacity chamber) 84 formed along the intake-side passages 71, 72 at a position closer to the control chamber; a pressure-sensitive body (bellows) 78 positioned in the third valve chamber to apply a bias force in the extending (expanding) direction and also to contract as the surrounding pressure increases; a valve seat body (engagement part) 80 provided on the free end of the pressure-sensitive body in the expanding/contracting direction and having a circular seating surface; a third valve part (valve-opening connection part) 79 that moves integrally with the valve element 81 in the third valve chamber 84 and is able to open/close the intake-side passages by engaging with and separating from the valve seat body 80; and a solenoid S that applies an electromagnetic drive force to the valve element 81.The capacity control valve 70 is also designed in such a way that, if a need arises during capacity control to change the control chamber pressure on the variable-capacity compressor, the discharge chamber and control chamber can be connected to allow for adjustment of the pressure in the control chamber (control chamber pressure) Pc, without having to provide a clutch mechanism on the compressor.", "Additionally, its constitution is such that, if the control chamber pressure Pc rises while the variable-capacity compressor is stopped, the third valve part (valve-opening connection part) 79 is separated from the valve seat body (engagement part) 80 to open the intake-side passages and thereby communicate the intake chamber and control chamber.", "On the capacity control valve 70 thus constituted, the relational expression of the force of each installed spring that generates a snapping force, and the balancing force generated by the pressure of working fluid that flows in, is given by Pc (Ab−Ar1)+Pc (Ar1−As)+Pd (As−Ar2)+Ps (Ar2−Ar1)+Ps×Ar1=Fb+S1−Fsol, based on the constitution shown in FIG.", "4.This relational expression can be organized as Pc (Ab−As)+Pd (As−Ar2)+Ps×Ar2=Fb+S1−Fsol.", "Then, assuming the relationship of pressure-receiving areas including the effective pressure-receiving area Ab of the pressure-sensitive body (bellows) 78, seal pressure-receiving area As of the first valve part 76, and pressure-receiving area Ar2 of the second valve part 75, to be Ab=As=Ar2, the above expression can be rewritten as Ps×Ar2=Fb+S1−Fsol.", "In other words, by making the effective pressure-receiving area Ab of the pressure-sensitive body (bellows) 78, seal pressure-receiving area As of the first valve part 76, and pressure-receiving area Ar2 of the second valve part 75 identical or roughly identical, the control accuracy of the capacity control valve 1 will improve because only the intake pressure Ps flowing from the intake-side passage 71 acts upon the valve element 81.The symbols in the aforementioned expression are as follows: Ab - - - Effective pressure-receiving area of the pressure-sensitive body (bellows) 78 Ar1 - - - Pressure-receiving area (cross-section area) of the third valve part 79 As - - - Seal pressure-receiving area of the first valve part 76 Ar2 - - - Pressure-receiving area of the second valve part 75 Fb - - - Snapping (spring) force of the pressure-sensitive body (bellows) (overall) S1 - - - Spring (snapping) means 85 Fsol - - - Electromagnetic force of the electromagnetic coil Ps - - - Intake pressure Pd - - - Discharge pressure Pc - - - Control pressure (crank chamber pressure) As described above, to achieve a capacity control valve of good control accuracy, the relationship of pressure-receiving areas including the effective pressure-receiving area Ab of the pressure-sensitive body 78, seal pressure-receiving area As of the first valve part 76, and pressure-receiving area Ar2 of the second valve part 75, must be Ab=As=Ar2, and therefore it can be said that the diameter of the capacity control valve is determined by the diameter of the pressure-sensitive body 78 or diameter of the valve element 81.In Prior Art 1, the pressure-sensitive body 78 hermetically connects one end of a metal bellows 78A to a partition adjustment part 86 and connects the other end to the valve seat body 80, and a coil spring 87 is housed in the bellows 78A.", "This bellows 78A is made of phosphor bronze to achieve good workability, but from the viewpoint of spring property, phosphor bronze has a small yield stress as a material itself and cannot ensure a long stroke, and also a bellows made of phosphor bronze tends to undergo characteristic changes such as drop in load when an excessive pressure is applied or during use at high temperature, which makes it impossible to reduce the diameter or eliminate the coil spring 87.To reduce the diameter of a phosphor bronze bellows, the thickness of the bellows must be increased and its length also increased in order to ensure long-enough stroke, meaning that a length dimension greater than the overall length of the current bellows is needed, which could result in poor formability and might also cause the bellows to project from the outer diameter dimension of the compressor because the overall length in the axial direction must be extended.", "For these reasons, the diameter of the valve element 81 must be increased in order to ensure the “maximum flow rate (valve full-open flow rate)” which is an important characteristic required of a capacity control valve.", "In other words, producing the bellows 78A using phosphor bronze makes it impossible to ensure a long stroke and therefore necessitates increasing the diameter of the pressure-sensitive body 78 and that of the valve element 81, and also in light of the tendency of such bellows to undergo characteristic changes, the coil spring 87 must be included, and consequently the diameter of the capacity control valve increases.", "On the other hand, it is proposed that a control valve of simple structure comprising a pressure-sensitive unit provided in a solenoid unit be obtained by designing the pressure-sensitive unit with a movable end formed on one end of a bellows using strong magnetic material and a fixed end formed on the other end of the bellows using strong magnetic material, and by opposingly positioning the movable end and fixed end inside the bellows with a specified gap provided in between so that the movable end and fixed end form a magnetic circuit for the solenoid unit; wherein such control valve is such that the bellows is formed with stainless material by considering the joining property of the movable end and fixed end formed with strong magnetic material (hereinafter referred to as “Prior Art 2,” refer to Patent Literature 2).", "However, the invention of Prior Art 2 was developed with the object of allowing the components of the pressure-sensitive unit to also function as the components of the solenoid unit because the magnetic circuit for the solenoid unit is formed in the pressure-sensitive unit, thereby simplifying the structure and helping reduce the cost, while also making it easy to assemble the control valve, and furthermore the idea of forming the bellows with stainless material is simply a way to achieve good joining property of the movable end and fixed end formed with strong magnetic material and it does not reduce the diameter of the capacity control valve, and consequently the diameter of the capacity control valve, including the outer diameter of the coil, remains large.", "CITATION LIST Patent Literatures Patent Literature 1: International Patent Laid-open No.", "2007/119380 Patent Literature 2: Japanese Patent Laid-open No.", "2011-117396 SUMMARY OF INVENTION Technical Problem The present invention was developed to solve the problems of Prior Arts 1 and 2 mentioned above, and the object of the present invention is to provide a capacity control valve which has no internal spring positioned in the bellows of the pressure-sensitive unit and also reduces the diameter of the valve element and that of the bellows to achieve size reduction and weight reduction.", "Solution to Problem To achieve the aforementioned object, firstly the capacity control valve proposed by the present invention comprises: discharge-side passages communicating a discharge chamber that discharges fluid and a control chamber that controls the discharge rate of fluid; a first valve chamber formed along the discharge-side passages; intake-side passages communicating an intake chamber that takes in fluid and the control chamber; a second valve chamber formed along the intake-side passages; a valve element that integrally has a first valve part that opens/closes the discharge-side passages in the first valve chamber and a second valve part that opens/closes the intake-side passages in the second valve chamber, where the two valve parts open/close in opposite directions due to reciprocating motion; a third valve chamber formed along the intake-side passages at a position closer to the control chamber than to the second valve chamber; a pressure-sensitive body positioned in the third valve chamber to apply, by extending, a bias force in the direction of opening the first valve part, and also to contract as the surrounding pressure increases; an adapter provided on the free end of the pressure-sensitive body in the extending/contracting directions, and having a circular seating surface; a third valve part that moves integrally with the valve element in the third valve chamber, and has a circular engagement surface that opens/closes the intake-side passages by engaging with and separating from the seating surface of the adapter; and a solenoid that applies an electromagnetic drive force to the valve element in the direction of closing the first valve part; wherein such capacity control valve is characterized in that: the pressure-sensitive body is formed by a formed bellows made of material having greater yield stress than phosphor bronze; and the formed bellows has its diameter set smaller and its stroke longer than the diameter and stroke of a phosphor bronze bellows.", "According to these features, the diameter of the bellows and that of the valve element can be reduced and response of the valve element can be improved, while at the same time the diameter of the valve body can be reduced.", "Furthermore, the diameter of the capacity control valve containing the solenoid can be reduced and consequently the capacity control valve can be made lighter and more space-saving.", "Eventually, such capacity control valve can contribute to the size reduction and weight reduction of a swashplate-type variable-capacity compressor and weight reduction of a vehicle, thus helping provide environmentally friendly products.", "Additionally, a smaller bellows diameter leads to a smaller adapter diameter, which in turn improves the vibration resistance of the bellows and also improves the vibration resistances of other movable parts as a result of reduced weights of the parts due to diameter reduction.", "All these can ultimately contribute to improved durability.", "Secondly, the capacity control valve proposed by the present invention is characterized in that, in the first feature, the pressure-sensitive body is preferably formed with austenitic stainless material.", "According to these features, a pressure-sensitive body having high spring property and yield stress and suitable for diameter reduction can be obtained.", "Thirdly, the capacity control valve proposed by the present invention is characterized in that, in the first or second features, the adapter provided on the free end of the formed bellows and partition adjustment member provided on the fixed end are formed with non-magnetic material.", "Fourthly, the capacity control valve proposed by the present invention is characterized in that, in the third feature, the partition adjustment member is preferably formed with austenitic stainless material.", "According to the third and fourth features, good sliding property is achieved when the pressure-sensitive body is press-fit into the valve body via the partition adjustment member, which leads to ease of manufacturing.", "Fifthly, the capacity control valve proposed by the present invention is characterized in that, in the third or fourth feature, the formed bellows, adapter, and partition adjustment member are fixed by means of electron beam welding, and the interior of the formed bellows is kept in an absolute vacuum state.", "According to these features, the interior of the formed bellows can be kept in an absolute vacuum state by utilizing the advantages of electron beam welding, which in turn makes it possible to sense the absolute intake pressure and which thereby improves the sensing accuracy.", "Also because the bellows, partition adjustment member, and adapter, all formed with the same non-magnetic material, are fixed by means of electron beam welding, welding becomes easy and welding reliability can be improved.", "Advantageous Effects of Invention The present invention has excellent effects as described below: (1) The pressure-sensitive body is formed by a formed bellows made of material having greater yield stress than phosphor bronze, and the formed bellows has its diameter set smaller and its stroke longer than the diameter and stroke of a phosphor bronze bellows, and therefore the diameter of the bellows and that of the valve element can be reduced and response of the valve element can be improved and also the diameter of the valve body can be reduced.", "Furthermore, the diameter of the capacity control valve containing the solenoid can be reduced and consequently the capacity control valve can be made lighter and more space-saving.", "Eventually, such capacity control valve can contribute to the size reduction and weight reduction of a swashplate-type variable-capacity compressor and weight reduction of a vehicle, thus helping provide environmentally friendly products.", "Additionally, a smaller bellows diameter leads to a smaller adapter diameter, which in turn improves the vibration resistance of the bellows and also improves the vibration resistances of other movable parts as a result of reduced weights of the parts due to diameter reduction.", "All these reductions can ultimately contribute to improved durability.", "(2) The pressure-sensitive body is preferably formed with austenitic stainless material such that a pressure-sensitive body having high spring property and yield stress and which is suitable for diameter reduction can be obtained.", "(3) The adapter provided on the free end of the formed bellows and partition adjustment member provided on the fixed end are formed with non-magnetic material, and the partition adjustment member is preferably formed with austenitic stainless material, and therefore good sliding property is achieved when the pressure-sensitive body is press-fit into the valve body via the partition adjustment member, which leads to ease of manufacturing.", "(4) The formed bellows, adapter, and partition adjustment member are fixed by means of electron beam welding, and the interior of the formed bellows is kept in an absolute vacuum state, and since the interior of the formed bellows can be kept in an absolute vacuum state by utilizing the advantages of electron beam welding, it becomes possible to sense the absolute intake pressure and the sensing accuracy improves as a result.", "Also because the bellows, partition adjustment member, and adapter, all formed with the same non-magnetic material, are fixed by means of electron beam welding, welding becomes easy and welding reliability can be improved.", "BRIEF DESCRIPTION OF DRAWINGS FIG.", "1 This is a schematic block diagram showing a swashplate-type variable-capacity compressor equipped with a capacity control valve conforming to the present invention.", "FIG.", "2 This is a longitudinal section view showing an overview of the capacity control valve pertaining to an embodiment of the present invention.", "FIG.", "3 These are enlarged views of pressure-sensitive bodies of capacity control valves, where (a) shows the capacity control valve pertaining to an embodiment of the present invention, while (b) shows the capacity control valve in Prior Art 1.FIG.", "4 This is a longitudinal section view showing an overview of the capacity control valve in Prior Art 1.FIG.", "5 This is an enlarged section view of the capacity control valve pertaining to another embodiment of the present invention, showing a position of the screw grooves when the first valve part is closed.", "FIG.", "6 This is an enlarged section view of the capacity control valve pertaining to said another embodiment of the present invention, showing a position of the screw grooves when the first valve part is opened.", "DESCRIPTION OF EMBODIMENTS A mode for carrying out a capacity control valve pertaining to the present invention is explained in detail by referring to the drawings, but it should be noted that interpretations of the present invention are not at all limited to the following, and various changes, modifications, and improvements can be added based on the knowledge of those skilled in the art so long as they do not deviate from the scope of the present invention.", "As shown in FIG.", "1, a swashplate-type variable-capacity compressor M comprises, for example: a casing 10 that defines a discharge chamber 11, a control chamber (also referred to as “crank chamber”) 12, an intake chamber 13, multiple cylinders 14, a port lib that communicates each cylinder 14 and the discharge chamber 11 and is opened/closed by a discharge valve 11a, a port 13b that communicates each cylinder 14 and the intake chamber 13 and is opened/closed by an intake valve 13a, a discharge port 11c and intake port 13c connected to an external cooling circuit, a connection passage 15 that serves as a discharge-side passage communicating the discharge chamber 11 and control chamber 12, a connection passage 16 that serves as the discharge-side passage and also as an intake-side passage communicating the control chamber 12 and intake chamber 13; and a connection passage 17 that serves as an intake-side passage, etc.", "; a rotational axis 20 projecting outward from inside the control chamber (crank chamber) 12 in a freely rotatable manner; a swashplate 21 that turns integrally with the rotational axis 20 and is connected in a manner allowing for change in its inclination angle relative to the rotational axis 20; multiple pistons 22 engaged in the respective cylinders 14 in a manner freely undergoing reciprocating motion; multiple connection members 23 connecting the swashplate 21 and respective pistons 22; a driven pulley 24 installed on the rotational axis 20; and a capacity control valve V conforming to the present invention which is embedded in the casing 10.Also, the swashplate-type variable-capacity compressor M has a connection passage 18 that directly communicates the control chamber (crank chamber) 12 and intake chamber 13, where a fixed orifice 19 is provided in the connection passage 18.Furthermore, this swashplate-type variable-capacity compressor M has a cooling circuit connected to the discharge port 11c and intake port 13c, and a condenser 25, expansion valve 26, and evaporator 27 are sequentially provided in this cooling circuit.", "As shown in FIG.", "2, the capacity control valve V comprises, for example: a valve body 30 formed with metal material or resin material; a valve element 40 positioned in the valve body 30 in a manner freely undergoing reciprocating motion; a pressure-sensitive body 50 that biases the valve element 40 in one direction; and a solenoid 60 connected to the valve body 30 and applying an electromagnetic drive force to the valve element 40.The solenoid 60 comprises, for example: a casing 62 connected to the valve body 30; a sleeve 63 having one end closed; a cylindrical fixed iron core 64 positioned on the interior side of the casing 62 and sleeve 63; a driving rod 65 forming a connection passage 44 on the interior side of the fixed iron core 64 in a manner freely undergoing reciprocating motion, with its tip connected to the valve element 40; a movable iron core 66 bonded to the other end of the driving rod 65; a coil spring 67 that biases the movable iron core 66 in the direction of opening a first valve part 41; and an excitation coil 68 wound on the exterior side of the sleeve 63 via a bobbin.", "The valve body 30 comprises, for example: connection passages 31, 32, 33 that function as discharge-side passages; connection passages 33, 34 that function as intake-side passages together with the connection passage 44 of the valve element 40 described later; a first valve chamber 35 formed along the discharge-side passages; a second valve chamber 36 formed along the intake-side passages; a guide passage 37 that guides the valve element 40; and a third valve chamber 38 formed along the discharge-side passages and intake-side passages at a position closer to the control chamber 12.Also, a partition adjustment member 39 that defines the third valve chamber 38 and also constitutes a part of the valve body 30 is press-fit into the valve body 30.In other words, the connection passage 33 and third valve chamber 38 are formed in a manner also serving as a part of the discharge-side passages and intake-side passages, while the connection passage 32 communicates the first valve chamber 35 and third valve chamber 38 and also forms a valve hole through which the valve element 40 is inserted (gaps through which fluid flows are ensured as the valve element 40 is inserted).", "Note that the connection passages 31, 33, 34 are each provided in a multiple number (such as four at 90-degree intervals) and positioned radially in the circumferential direction.", "Also, in the first valve chamber 35, a seating surface 35a on which the first valve part 41 of the valve element 40 described later is seated is formed on the rim of the connection passage (valve hole) 32, while, in the second valve chamber 36, a seating surface 36a on which the second valve part 42 of the valve element 40 described later is seated is formed at the edge of the fixed iron core 64 described later.", "The valve element 40 is formed in an approximate cylinder shape and comprises, for example: a first valve part 41 on one end; a second valve part 42 on the other end; a third valve part 43 connected as an add-on to a side opposite to the second valve part 42 side by sandwiching the first valve part 41 in between; and a connection passage 44 that penetrates from the second valve part 42 to the third valve part 43 in the axial direction and functions as an intake-side passage.", "The third valve part 43 is formed in a manner flaring from a diameter-reduced state from the first valve chamber 35 toward the third valve chamber 38 and is guided through the connection passage (valve hole) 32, and also comprises a circular engagement surface 43a opposingly facing the adapter 53 described later on its outer periphery rim.", "The pressure-sensitive body 50 comprises a bellows 51, adapter 53 and partition adjustment member 39, for example.", "The bellows 51 is fixed on one end to the partition adjustment member 39 and retains the adapter 53 on the other end (free end).", "As shown in FIG.", "3, the adapter 53 has a hollow cylindrical part 53a whose tip engages with the third valve part 43 and whose cross-section has an approximate C shape, as well as a bulging part 53c that bulges into the bellows 51, and a circular seating surface 53b that opposingly engages with and separates from the engagement surface 43a of the third valve 43 is provided at the tip of the hollow cylindrical part 53a.", "The pressure-sensitive body 50 is positioned in the third valve chamber 38 to apply, by extending (expanding), a bias force in the direction of opening the first valve part 41, and also to contract as the surrounding pressure (in the third valve chamber 38 and connection passage 44 of the valve element 40) increases, thereby actuating to weaken the bias force applied to the first valve part 41.FIG.", "3 shows enlarged views of pressure-sensitive bodies of capacity control valves, where (a) shows the capacity control valve pertaining to the embodiment of the present invention, while (b) shows the capacity control valve in Prior Art 1.In FIG.", "3, the bellows 51 of the pressure-sensitive body 50 in the capacity control valve V pertaining to the embodiment of the present invention shown in (a) is formed by a formed bellows made of material having greater yield stress than phosphor bronze, or, for example, preferably by a formed bellows made of austenitic stainless material, where the bellows 51 has its diameter set smaller and its stroke longer than the diameter and stroke of the phosphor bronze bellows 78A under Prior Art 1 shown in (b).", "Also, while the pressure-sensitive body 78 under Prior Art 1 has a coil spring 87 in the bellows 78A, no internal spring or other such member is provided in the bellows 51 of the pressure-sensitive body 50 under the present invention.", "Furthermore, the gap a between the end of the bulging part 39a that bulges into the bellows 51 of the partition adjustment member 39 on one hand, and the end of the bulging part 53c that bulges into the bellows 51 of the adapter 53 on the other, is set larger than the corresponding gap under Prior Art 1.One end (fixed end) of the bellows 51 is fixed to the partition adjustment member 39, while the adapter 53 is retained at the other end (free end), where the partition adjustment member 39, and adapter 53 are formed with non-magnetic material.", "The partition adjustment member 39 is preferably formed with austenitic stainless material.", "The bellows 51, partition adjustment member 39, and adapter 53 are fixed by means of electron beam welding and the interior of the formed bellows is kept in an absolute vacuum state.", "The formed bellows pertaining to the embodiment of the present invention, made of material having greater yield stress than phosphor bronze, has higher spring property compared to the phosphor bronze bellows and thus allows the internal spring to be eliminated and diameter B1 of the bellows 51 to be reduced, and because its yield stress itself is also high, a longer stroke can be provided.", "Even when the diameter of the valve element 40 is reduced, therefore, a long stroke can be provided to compensate for the smaller degree of opening of the valve element 40, effectively permitting diameter reduction of the valve element 40 and improving the response of the valve element 40.Because the diameter of the valve element 40 can be reduced, the diameter B2 of the valve body 30 can also be reduced.", "Furthermore, the diameter B3 of the capacity control valve V containing the solenoid 60 can also be reduced, which makes the capacity control valve lighter and more space-saving.", "This space-saving design also contributes to the size reduction and weight reduction of a swashplate-type variable-capacity compressor M and weight reduction of a vehicle, thus helping provide environmentally friendly products.", "Furthermore, a smaller bellows 51 diameter leads to a smaller adapter 53 diameter, which in turn improves the vibration resistance of the bellows 51 and also improves the vibration resistances of other movable parts as a result of reduced weights of the parts due to diameter reduction.", "All these can ultimately contribute to improved durability.", "When the capacity control valve V pertaining to an embodiment of the present invention is compared with the capacity control valve 70 under Prior Art 1, the following are found: Bellows diameter B1/B1′=5.95/7.9=0.75 Valve body diameter B2/B2′=14.9/18.8=0.79 Capacity control valve diameter B3/B3′=21.7/23.6=0.92 As the figures show, the diameters are significantly smaller.", "Additionally, since the valve body 30 is normally made of brass, use of phosphor bronze for the pressure-sensitive body 78 under Prior Art 1 results in the two parts having similar hardness and consequently, poor sliding property when the partition adjustment part 86 is press-fit into the valve body 30.On the other hand, the capacity control valve V pertaining to an embodiment of the present invention allows its partition adjustment member 39, and adapter 53 to be formed with non-magnetic material instead of strong magnetic material as in Prior Art 2, and therefore when at least the partition adjustment member 39 is formed with austenitic stainless material, greater sliding property is achieved when the partition adjustment member 39 is press-fit into the valve body 30 because both have a different hardness, and ease of manufacturing is ensured as a result.", "Furthermore, the capacity control valve V pertaining to an embodiment of the present invention is such that the bellows 51, partition adjustment member 39, and adapter 53 are fixed by means of electron beam welding, and by positioning the cathode in the formed bellows, the interior of the formed bellows can be kept in an absolute vacuum state when the parts are welded, and this allows for sensing of the absolute intake pressure Ps and improves the sensing accuracy compared to when the interior of the bellows is simply kept in negative pressure as is the case of Prior Art 2.Also, because the bellows 51, partition adjustment member 39, and adapter 53 can be formed with the same stainless material, stable production is possible by means of electron beam welding and the reliability improves as a result.", "The foregoing explained an embodiment of the present invention by referring to the drawings, but specific constitutions are not at all limited to the embodiment and the present invention also includes changes and additions made to the extent that they do not deviate from the gist of the present invention.", "For example, the aforementioned embodiment cited austenitic stainless material as a favorable material for the pressure-sensitive body because it has greater yield stress than phosphor bronze and therefore demonstrates higher spring property and yield stress and is suitable for diameter reduction.", "However, the material is not at all limited to the foregoing and ferritic stainless material may be used, as well.", "Also in the aforementioned embodiment, the partition adjustment member and adapter were formed with non-magnetic material, for example.", "However, their material is not at all limited to the foregoing and, if the pressure-sensitive body uses ferritic stainless material, the same material may be used, as well.", "FIG.", "5 and FIG.", "6 are diagrams showing an enlarged section of the capacity control valve pertaining to the second example of the present invention.", "In the explanation below, the example shown in FIG.", "1, FIG.", "2 and FIG.", "3(a) is referred to as first example, and the example shown in FIG.", "5 and FIG.", "6 is referred to as second example.", "FIG.", "5 and FIG.", "6 are enlarged section views for showing difference with the first example, which show positions of the valve element when the first valve part is closed and when the first valve part is opened, respectively.", "In explanation of the second example, a component identical to that of the first example is designated with the same sign, and an explanation thereof is omitted to avoid an overlapping explanation, and mainly, portions different from the first example are explained.", "In FIG.", "5 and FIG.", "6, the capacity control valve V100 representing the second example comprises, for example, a valve element 110, a pressure-sensitive body 50 and a solenoid 60.The valve element 110 integrally has a first valve part 41 that opens/closes connection passages 31 and 32 as discharge-side passages in a first valve chamber 35 and a second valve part 42 that opens/closes a connection passage 34 as an intake-side passage in a second valve chamber 36, where the two valve parts open/close in opposite directions due to reciprocating motion.", "Needless to say, the valve element 110 is also driven by an electromagnetic drive force of a solenoid 60 shown in FIG.", "2 (illustration omitted in FIG.", "5 and FIG.", "6), so as to be moved to the side of the pressure-sensitive body 50 as in the first example.", "The valve element 110 is accommodated in a valve body 30 so as to be allowed a reciprocating motion, and cooperate with the valve body 30 to define the first valve chamber 35 and the second valve chamber 36.The valve element 110 is located between the first valve chamber 35 and the second valve chamber 36, and has an outer circumferential face part 120 which is slidably movable relative to an inner circumferential face 30a of the valve body 30.On this outer circumferential face part 120, multiple-thread screw grooves 130 are formed.", "In the second example shown in FIG.", "5 and FIG.", "6, the pressure-sensitive body 50 is a springless type pressure-sensitive body which is not provided with a spring for biasing the valve element 110 toward the side of the solenoid 60, similarly as in the first example shown in FIG.", "1, FIG.", "2, and FIG.", "3(a), the springless type referring to such a type that is not provided with the spring 87 in the conventional capacity control valve shown in FIG.", "3 (b) and FIG.", "4.In the second example in which such a springless type pressure-sensitive body 50 is used, it is possible to make the bias force against the valve element 110 comparatively small, by keeping the interior of the bellows 51 in a vacuum state.", "As a result, it is possible to reduce the electromagnetic drive force of the solenoid 60 and achieve an energy-saving effect.", "However, on the other hand, there is a possibility that, when released from the electromagnetic drive force of the solenoid 60, the valve element 110 becomes hard to be brought back to the side of the solenoid 60 by a comparative small bias force of the bellows 51.Specifically, between the outer circumferential face part 120 of the valve element 110 and the inner circumferential face 30a of the valve body 30, an adhesive force is partially generated between the outer circumferential face part 120 and the inner circumferential face 30a, due to an eccentricity.", "As a result, a frictional force gives a comparatively significant influence to a relative movement of the valve element 110 and the valve body 30.In such a case, the valve element 110 receives the comparatively significant influence of the adhesive force or the frictional force between the outer circumferential face part 120 and the inner circumferential face 30a of the valve body 30, causing a poor functioning that the valve element 110 becomes hard to move.", "In order to sort out this poor functioning, the capacity control valve V100 is provided with the screw grooves 130 that is an important feature of the present invention.", "As shown in FIG.", "5, when the first valve part 41 is closed, each of the screw grooves 130 communicates with the first valve chamber 35 and does not communicate with the second valve chamber 36.Meanwhile, as shown in FIG.", "6, when the first valve part 41 is opened, each of the screw grooves 130 communicates neither with the first valve chamber 35 nor the second valve chamber 36.In this connection, the closed state of the first valve part 41 is a state where the first valve part 41 is seated on the valve seat 30b as shown in FIG.", "5, and the open state is a state where the first valve part 41 is separated from the valve seat 30b as shown in FIG.", "6.In the second example shown in FIG.", "5 and FIG.", "6, the screw grooves 130 are provided in two threads, in a position equally spaced in the circumferential direction.", "In other words, when the first valve part 41 is closed, the screw grooves 130 of two threads each communicate with the first valve chamber 35 at a position 180° turned around the central axis of the valve element 110.At least one end in the side of the first valve chamber 35 of each of the screw grooves 130 is an incomplete screw part 130a.", "The incomplete screw part 130a refers to an end of a screw groove in which a depth and a width of a screw groove 130 is gradually reduced toward the screw end.", "In the second example, a length of the incomplete screw part 130a is set such that when the first valve part 41 is closed, only the incomplete screw part 130a in a screw groove 130 opens to the first valve chamber 35 to communicate with the first valve chamber 35, as shown in FIG.", "5.On the other hand, the end in the side of the second valve chamber 36 of a screw groove 130 may be an incomplete screw part, though not illustrated.", "The capacity control valve V100 configured as described above not only naturally has the effects similar to those of the capacity control valve V1 of the first example shown in FIG.", "1, FIG.", "2 and FIG.", "3 (a), but further has the following effects.", "When the solenoid 60 applies an electromagnetic drive force to the valve element 110, and the valve element 110 moves to the side of the pressure-sensitive body 50, the first valve chamber 35 is closed.", "At this time, the incomplete screw parts 130a of the screw grooves 130 open to the first valve chamber 35 so that the first valve chamber 35 communicates with the screw grooves 130, and the screw grooves 130 are filled with a working fluid in the first valve chamber 35.Next, when the electromagnetic drive force of the solenoid 60 is removed, the valve element 110 is to be moved toward the side of the solenoid 60 by an extension (expansion) of the pressure-sensitive body 50.At this time, there is a concern that the valve element 110 becomes hard to be moved due to a comparatively significant influence of an adhesive force and a frictional force between the outer circumferential face part 120 and the inner circumferential face 30a of the valve body 30.However, the working fluid, which filled the screw grooves 130 when the first valve part 41 is closed, is not discharged from the screw grooves 130, since when the first valve part 41 is opened, the screw grooves 130 have no communication with the first valve chamber 35, and the working fluid is taken between the inner circumferential face 30a of the valve body 30 and the outer circumferential face part 120 of the valve element 110 to allow a high pressure to be maintained over the entire circumference.", "As a result, a lubricating effect of the working fluid in the screw grooves 130 reduces the adhesive force and the frictional force between the inner circumferential face 30a of the valve body 30 and the outer circumferential face part 120 of the valve element 110.Accordingly, even a weak bias force of the pressure-sensitive body 50 to the valve element 110 can smoothly move the valve element 110 to the side of the solenoid 60, and can surely open the first valve part 41 to a targeted degree of opening.", "In addition, since the screw grooves 130 are provided in a position equally spaced in the circumferential direction, it is possible to capture the working fluid of the first valve chamber 35 evenly between the valve element 110 and the valve body 30, and it is possible to reduce the frictional force between the inner circumferential face 30a of the valve body 30 and the outer circumferential face part 120 of the valve element 110 uniformly in the circumferential direction.", "Furthermore, since at least one end in the side of the first valve chamber 35 of each of the screw grooves 130 is the incomplete screw part 130a, it is possible to reduce a level difference of the screw groove 130 relative to the outer circumferential face part 120 of the valve element 110, in the incomplete screw part 130a.", "As a result, at a start of movement of the valve element 110, it is possible to control a rapid change of pressure of the working fluid, in the level difference of the incomplete screw part 130a which opens to the first valve chamber 35.In addition, since the incomplete screw part 130a is formed at the end in the side of the first valve chamber of the screw grooves 130 as described above, when the valve element 110 is moved from the direction of closing the first valve chamber 35 to the direction of opening the first valve chamber 35, it is possible to inhibit the working fluid in the screw grooves 130 from being discharged to the first valve chamber 35, and accordingly, a sufficient lubricating effect by a high pressure working fluid is secured between the inner circumferential face 30a of the valve body 30 and the outer circumferential face part 120 of the valve element 110.Furthermore, when the first valve part 41 is closed, each of the screw grooves 130 communicates with the first valve chamber 35, in such a manner that only the incomplete screw part 130a in the end in the side of the first valve chamber 35 opens to the first valve chamber 35.Therefore, it is possible to further control the above-described rapid change of the working fluid at a start of movement of the valve element 110 and the discharge of the working fluid in the screw grooves 130 to the first valve chamber 35 when the first valve chamber is opened, and accordingly, it is possible to further ensure the improvement in lubricating performance.", "Incidentally, the capacity control valve pertaining to the present invention should not be limited to those in the second example shown in FIG.", "5 and FIG.", "6, and other modified modes are naturally included in the scope of the present invention, so long as they are in a scope not deviate from the gist of the present invention.", "REFERENCE SIGNS LIST 10 Casing 11 Discharge chamber 12 Control chamber (crank chamber) 13 Intake chamber 14 Cylinder 15 Connection passage 16 Connection passage 17 Connection passage 18 Connection passage 19 Fixed orifice 20 Rotational axis 21 Swashplate 22 Piston 23 Connection member 24 Driven pulley 25 Condenser 26 Expansion valve 27 Evaporator 30 Valve body 30a Inner circumferential face 30b Valve seat 31, 32 Connection passage (discharge-side passage) 33 Connection passage (control chamber-side passage) 34 Connection passage (intake-side passage) 35 First valve chamber 35a Seating surface 36 Second valve chamber 36a Seating surface 37 Guide passage 38 Third valve chamber 39 Partition adjustment member 40 Valve element 41 First valve part 42 Second valve part 43 Third valve part 43a Engagement surface 44 Connection passage 50 Pressure-sensitive body 51 Bellows 53 Adapter 53a Hollow cylindrical part 53b Circular seating surface 53c Bulging part 60 Solenoid 62 Casing 63 Sleeve 64 Fixed iron core 65 Driving rod 66 Movable iron core 67 Coil spring 68 Excitation coil 87 Spring 110 Valve element 120 Outer circumferential face part 130 Screw grooves 130a Screw part M Swashplate-type variable-capacity compressor V Capacity control valve Pd Discharge pressure Ps Intake pressure Pc Control chamber pressure" ] ]
Patent_15872781
[ [ "BLADE COMPRISING A SHANK, PROVIDED WITH A DEPRESSED PORTION", "The shank of a blade includes a first side and a second side provided with a depression.", "By concentrating this depression on a single side, a shank that is more rigid and resistant with an equal lightening is obtained, with the stress concentrations depending on the depth of the depression but being absent from first flat side.", "The vibrations and bending deformations are also reduced." ], [ "1.A blade comprising: a vane; and a foot, the foot comprising successively, by moving away from the vane, a platform, a shank and a bulb, the shank being connected to the platform and to the bulb by junction lines, the shank comprising first and second main faces respectively directed in a suction side and a pressure side of the blade and parallel, wherein the first main face is substantially plane or curvilinear, and the second main face is provided with a depressed portion extending over a depth of at least 25% of a thickness of the shank between the first and second main faces, and the depressed portion is limited by two main sides respectively parallel to the junction lines, said main sides being separated, along each line in a height direction of the blade which extends from the bulb to a tip edge of the vane, by a distance D1 which is at least 50% of a distance D2 separating the junction lines.", "2.The blade according to claim 1, wherein the depressed portion extends over at least 35% of the thickness of the shank.", "3.The blade according to claim 1, wherein the depressed portion has a bottom that is substantially flat or curvilinear surrounded by a curved edge that connects to the bottom without forming an angle.", "4.The blade according to claim 2, wherein the depressed portion has a bottom that is substantially flat or curvilinear surrounded by a curved edge that connects to the bottom without forming an angle.", "5.The blade according to claim 1, wherein the depressed portion is limited by rectilinear sides joined by curvilinear transitions.", "6.The blade according to claim 1, wherein said two main sides are separated by at least 66% of the distance separating the junction lines.", "7.The blade according to claim 1, wherein the depressed portion has a maximal dimension D1max in said height direction superior to at least 0.67 times a maximal dimension in a length direction of the foot which is perpendicular to the height direction.", "8.The blade according to claim 1, wherein the depressed portion spans at least 40% of a distance L2 between two opposite free edges of said second main face.", "9.The blade according to claim 1, wherein the depressed portion spans at least 50% of a distance L2 between two opposite free edges of said second main face.", "10.The blade according to claim 1, wherein the depressed portion is limited by three sides only including said two main sides, and transitions between said three sides, the transition between said two main sides being curvilinear with a constant radius of curvature, a third side of said three sides being parallel to a free edge of said second main face.", "11.The blade according to claim 10, wherein the blade is a blade at a first stage of blades in a compressor.", "12.The blade according to claim 1, wherein the shank connects to the bulb by a juncture having a constant radius of curvature and portions joined to the shank and the bulb and respectively tangent thereto." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation-in-part application of U.S. application Ser.", "No.", "14/579,426 filed Dec. 22, 2014, which claims priority to France Application No.", "13 63374 filed Dec. 23, 2013.U.S.", "application Ser.", "No.", "14/579,426 is herein incorporated by reference in its entirety for all purposes.", "DESCRIPTION This invention relates to a blade comprising a shank provided with a depressed portion on a single side.", "This blade, which can be a turbomachine compressor blade, comprises an outside vane subjected to aerodynamic forces, and a foot retained in a rotating disc; the foot comprises a platform flush with the surface of the disc and from which the vane rises, a bulb retaining the blade against the centrifugal forces and retained in an enlargement of a groove of the disc, and a shank joining the bulb to the platform, and housed in a main portion of the groove.", "Portions with a depression have sometimes been dug into the main or lateral faces of the shank so as to lighten the blade.", "Disadvantages, such as local increases in the static stresses and an alteration in the frequency of the bending modes, have however been observed with respect to blades of which the shanks are devoid of a depression.", "In French patent application 12 60527, it was undertaken to reduce these disadvantages and to bring the behaviour of the blade provided with portions with a depression closer to that of a blade with perfectly flat shanks, by choosing dissymmetric portions with a depression, in particular with regards to the depth.", "This application clearly specifies that the portions with a depression are established on the two main sides of the shank.", "Document U.S. Pat.", "No.", "5,435,694 A describes a blade wherein the shank is joined to the platform or to the bulb by fillets, which are mouldings with a slightly concave section, in order to reduce the stress that the blade in service is subjected to.", "Portions slightly with a depression are added in order to reinforce this effect, by decreasing the concentrations of stress around the fillets.", "These portions with a depression are defined by two successive radii of curvature and are superficial.", "They are much smaller in height (they extend only in a part of the shank height between the platform and the bulb) than in the length direction of the shank.", "It is not sought to lighten the blade by means of these portions with a depression or by fillets, which are shallow, but only to relieve stress concentrations.", "GB 2 162 588 A describes a blade shank provided with a recess that opens onto one of the end faces of the shank in order to lighten it.", "This design is suitable for relatively thick shanks.", "The structure of the shank remains symmetrical in the angular direction on either side of a median plane extending in the length of the shank.", "The invention relates to a lightened blade, designed to minimise the degradations in aeromechanical performance, in particular concerning the concentrations of stress and the frequency of the bending modes.", "According to the invention, one of the main faces of the shank is substantially plane or curvilinear—in any case with a regular surface without relief—while the other of the main faces is provided with a depressed portion, extending over a depth of at least 25%, and advantageously by at least 35%, of a thickness of the shank, between the main faces.", "It is specified that the main faces of the shank—which extends roughly in the axial direction of the disc and of the turbomachine to which the blade belongs—are the lateral faces with the largest surface area, roughly perpendicular to the angular direction of the disc and of the machine, giving onto the intrados and extrados sides of the blade, and extending in the length direction of the foot of the blade, which corresponds to its direction of insertion into the cutout of the disc, and in the height direction of the foot, which corresponds to the radial direction of the blade in the machine, from the foot to the tip of the vane.", "And the depressed portion is limited by two main sides, respectively parallel to junction lines of the shank to the bulb and to the platform, said main sides being separated, along each line in the height direction of the blade crossing said main sides, by at least 50% of a distance separating said junction lines.", "Unlike in U.S. Pat.", "No.", "5,435,694 A, the greatest possible area and a greater depth are allotted to the depressed portion in order to obtain an important lightening.", "But this lightening should not entail a loss of mechanical characteristics, especially stiffness to vibrations and resistance to shocks produced by ingestion of solid bodies, compared to blades having a foot with a uniform cross-section and a regular shape.", "A satisfactory result in these aspects has been stated with the blade feet of the invention, which have a dissymmetric cross-section, since the depressed portion is provided on one face only, the other face remaining smooth: this other face maintains the resistance and stiffness qualities of the blade almost completely, even when an important lightening has been obtained after the opposite face has been hollowed.", "Depressed portions symmetrically arranged in both main faces would not maintain these characteristics well, nor would a general thickness reduction of the shank.", "For the same reasons, the inventive depressed portion does not extend to the free ends of the foot (in the length direction thereof), and it is normally defined by a closed, continuous outline.", "The degradation in the performance obtained on the blade is then clearly less substantial than with portions with a depression distributed symmetrically on the two sides of the shank, or even than with the portions with a depression opposite and moderately dissymmetric considered in application FR 12 60527.And GB 2 162 588 does not suggest that a dissymmetric shank in the angular direction would improve the rigidity of the shank in the same direction wherein the bending of the blade is exerted.", "Indeed, flatness maintained on one of the main faces increases the rigidity of the blade with regards to the deformations in bending and prevents the introduction of concentrations of stress on one side: it can therefore be considered to arrange the depression on the side where the concentrations of stress are the least feared, i.e.", "the side that is the least loaded in the critical situations to be considered, such as the loss of a blade, in order to obtain a globally satisfactory distribution over the blade by not weakening the other side.", "According to other optional improvements, the depressed portion has a bottom that is substantially flat or curvilinear (parallel to the main face, and therefore at a uniform depth), surrounded by a curved edge, connecting to the bottom without forming an angle, in order to obtain a good lightening without favouring concentrations of stress at the edge of the portion; and it is advantageously limited by rectilinear sides joined by curvilinear transitions.", "The dimensioning of the depressed portion can also comply with certain general rules, pursuant to the principle mentioned above that the area is advantageously as great as possible for obtaining a great lightening.", "The height of the depressed portion (in the height direction of the foot, or radial direction of the blade) is thus not limited to the 50% value of the distance between the junction lines of the shank to the bulb and the platform; contrarily, it is advantageous that this height be superior, e. g. at least 66% of this distance.", "Similarly, a great span of the depressed portion in the length direction of the foot (between the free ends) is sought.", "If this is possible, the depressed portion can extend from 30% to 80% (typically at least 40% or 50% in ordinary blade designs) of the distance between the opposite edges, at the free ends, of the main face on which it is provided.", "This arrangement is not always practicable, however, in situations in which the shank height steeply varies along the feet and may become too low near an end to receive the depression.", "The situation may arise e. g. for blades at the entrance of compressors, which is a place where one can favourably consider to insert the inventive blades.", "In a typical design, the depressed portion is limited by only three sides then, i. e. the two main sides already mentioned, which are linked with a curved transition having a constant radius of curvature, and a third side, parallel to a free edge of the face.", "Even then, the span of the depressed portion in the length direction of the foot is advantageously as great as possible.", "To synthesize the foregoing rules, one may remember that the depressed portion advantageously has, in the height direction, a maximal dimension which is superior to at least 0.67 times a maximal dimension in the perpendicular direction, or length direction, of the foot; and the depth of the depression is at least 25%, and more preferably 35%, of the shank thickness.", "It is contemplated that the shank will connect the bulb with a transition having a constant radius, and junctions to the shank and the bulb respectively tangent thereto so that no recess is present at this connection between the bulb and the shank.", "The invention shall now be described in liaison with the following figures: FIG.", "1 is a general view of the blade in the angular direction; FIG.", "2 is a view of the foot of the blade in the axial direction; FIGS.", "3 and 4 illustrate a particularly preferred embodiment of the invention; and FIG.", "5 illustrates the connection of the shank to the bulb.", "FIG.", "1 shows a blade in accordance with the invention, provided with a vane 1 to the exterior and with a foot 2 engaged in the rotating disc 3, with the foot 2 comprising a platform 4 joined to the vane 1, a bulb 5 opposite the platform 4, and a shank 6, joining the two latter items.", "As the platform 4 is conical, the shank 6 is trapezoidal.", "A tip edge of the vane 1 is referred to by 9, and a height direction R of the blade extends from the bulb 5 to the tip edge 9.The shank 6 comprises two main faces 7 and 8 opposite, shown in FIG.", "2, giving onto the pressure side and suction sides of the blade and extending roughly in the direction of the axis of rotation of the disc 3.The main face 7 is flat (smooth, with a linear or curvilinear extension), but the main face 8 is provided with a depressed portion 10, taking a flat bottom 12 and an edge 14 connecting the bottom 12 to the main face 8.The edge 14 is connected to the bottom 12 without forming any sharp angle, but with a progressive rounding.", "The depressed portion 10 is of trapezoidal shape, as shown in FIG.", "1, with a first longitudinal side 15, close to the bulb 5 and parallel to its junction with the shank 6, a second longitudinal side 16 close to the platform 4 and parallel to the connection between it and the shank 6, and two other sides 17 and 18, connecting the latter together and curvilinear at least at the ends.", "The depressed portion 10 can be present according to case on the pressure side or the suction side of the blade.", "By making use of a depression on a single side of the shank 6, the gain in mass is provided while still minimising the effect on the aerodynamic and mechanical behaviour of the blade: the static stress, the position of the first bending mode and the response of the first bending mode under substantial stress, are improved with respect to a blade comprising, for the same lightening, portions with a depression on the two sides.", "In relation to such a blade comprising two portions with a depression, it has been observed, in a design in accordance with the invention, wherein the thickness of the shank 6 (distance between the two main faces 7 and 8) was 15.4 mm and the depressed portion had a depth of 5.7 mm, a static stress at the output of the blade, on its contact surfaces with the disc 3, reduced by 5% in the most loaded zone with respect to a blade having depressions on the two sides and a similar lightening; and for a first bending mode, the deformations measured in the shank 6 were reduced by 30% following substantial stress such as floating (instability due to the interaction of the fluid with the structure of the vanes 1 which has for effect to amplify the vibration of the blades), ingestions of foreign bodies or the loss of a vane 1.It is therefore possible to hope for a better resistance, or a longer resistance in the case of fatigue, of the foot 2, and better resistance of the vanes 1 with regards to vibrations.", "It is to be added that the frequency of the bending mode is not modified by the concentration of the lightening of a single side, in such a way that the invention does not require having to again optimise the blade with regards to these frequencies, once the optimisation has been carried out for blades with shanks recessed on the two sides.", "The same considerations apply to blade shanks of which the main faces would be curvilinear instead of being flat: the depressed portion would again be located on only one of its main faces and would be dimensioned in the same way.", "A particularly preferred embodiment of the invention is represented in FIGS.", "3 and 4, which illustrate a blade to be disposed at the first stage in an inlet of a compressor in a turbojet machine.", "A part of the description of FIGS.", "1 and 2 holds here, and the elements of this embodiment that correspond to similar elements of the foregoing embodiment will carry the same numerals with an increase of 100.They are the vane 101, foot 102, platform 104, bulb 105, shank 106, the flat main face (the suction side here) 107, the other main face (the pressure side here) 108, depressed portion 110, bottom 112 and edge 114.Hereunder we indicate some characteristics specific to this embodiment, or which particularly deserve to be mentioned.", "The inner radius of the vane 101 steeply varies along the foot 102, and the shank 106 has a strongly trapezoidal shape, almost triangular here, the platform 104 being adjacent to the bulb 105 at a free edge 120 of the shank 106.The depressed portion 110 has the greatest possible area, taking into account the dimensions of the shank 106 and the curvature of the edge 114.It is triangular here, and it is defined by three rectilinear sides 115, 116 and 118.The side 115 is parallel to the junction line 121 between the bulb 105 and the shank 106, and adjacent thereto.", "The side 116 is approximately parallel to the junction line 122 between the shank 106 and the platform 104 and not far therefrom; because of reinforcing bumpers 123 of the platform 104 that connect to the upper part of shank 106, a distance must nonetheless be kept between this junction line 122 and the side 116.It is generally advantageous that the distance D1 between the main sides 115 and 116 which are parallel to the junction lines 121 and 122, and the distance D2 between these junction lines, satisfy the ratio D1/D2>50% at least, and better D1/D2>66%.", "This relationship is valid for any line extending in the height direction R (corresponding to the radial direction of the blade when it is installed in the machine, from the foot 102 to the tip of the vane 101), and intersecting the main sides 115 and 116, that is for almost all the area of the depressed portion 110 (except the ends in the length direction X, at which it is limited by other sides and curved junctions), although both D1 and D2 vary in the length direction X.", "The third side 118 of the depressed portion 110 is parallel to the free end 124 of the shank 106, opposite to the other free end 120 in the length direction X of the foot 102, perpendicular to the height direction R and corresponding to a direction of insertion of the foot 102 into a groove of the disc.", "Here again, the main sides are connected by curvilinear transitions having a great radius, one of which joining the main sides 115 and 116 adjacent to the junction lines 121 and 122.In the present case in which the shank 106 becomes very low near one of the free ends 120, the dimension L1 of the depressed portion 110 in the length direction X must be reduced so that the juncture 125 keeps a sufficient radius; if the shank 106 has a more regular height, the depressed portion could have a quadrangular shape and a greater length L1 so that a ratio L1/L2, in which L2 is the distance between the free ends 120 and 124, could reach 50% or more, up to 80%.", "This ratio L1/L2 may be over 30%, preferably over 40%, in embodiments similar to FIGS.", "3 and 4.The great span of the depressed portion 10 or 110 in the height direction R is illustrated also by this ratio, which is advantageous complied with: D1max/L1>0.67, greater values being more preferred.", "D1max is the maximal dimension of the depressed portion 10 or 110 in the height direction R. The depth of the depressed portion 110 in this embodiment conforms to the foregoing rules and may be 30% to 40% of the thickness of the shank 106.It will be noticed (FIG.", "5) that the junction line 121 between the bulb 105 and shank 106 does not comprise any depression but has a constant radius of curvature in cross-section, connecting to the surfaces of the bulb 105 and shank 106 with portions 126 and 127 tangent thereto, so that any sudden change of orientation or inclination is avoided, and no concavity is created, at this place." ] ]
Patent_15872782
[ [ "Shaft seal assembly", "An illustrative embodiment of a shaft seal assembly generally includes a fixed stator, a floating stator, and a sealing member.", "In the illustrative embodiment the fixed stator may be formed with one or more fluid conduits that are in fluid communication with one or fluid conduits formed in the floating stator.", "The fluid conduits in the floating stator may be in fluid communication with one or more fluid conduits formed in a sealing member.", "A rotational interface may exist between the sealing member and a shaft, and the various fluid conduits may be configured to create a fluid barrier at that interface.", "Other embodiments of a shaft seal assembly may create a fluid barrier at a rotational interface between a rotor and a floating stator." ], [ "1.A method of creating a pressurized fluid barrier between a shaft and a sealing member at an interface therebetween, said method comprising the steps of: a. engaging a fixed stator with a housing, wherein said shaft protrudes from and is rotatable with respect to said housing, and wherein said fixed stator comprises: i. an annular recess along a portion of a radial-interior surface of said fixed stator, wherein said annular recess includes first and second radially oriented surfaces and a circumferential axially oriented surface; ii.", "an inlet extending from a radial-exterior surface of said fixed stator to said annular recess in a generally radial direction, wherein said fixed stator is engaged with a housing at an aperture of said housing, wherein a shaft rotatable with respect to said housing extends outward from said aperture; b. positioning said shaft sealing member in said annular recess, wherein a predetermined clearance in a radial dimension between a radial-exterior surface said shaft sealing member and said radial-interior surface of said annular recess in said fixed stator is equal to an amount of allowed relative movement between said shaft sealing member and said fixed stator in said radial dimension, and wherein said shaft sealing member comprises: i. a floating stator having a radial-interior surface that is substantially concave in shape, wherein a pin recess is formed in said floating stator and extends from said radial-exterior surface of said shaft sealing member to said radial-interior surface of said floating stator; ii.", "a sealing member, wherein said sealing member includes a radial-exterior surface with a substantially convex shape that corresponds to the radial-interior surface of said floating stator so as to create a spherical interface therebetween, wherein said sealing member is positioned adjacent said shaft extending from said housing; and, iii.", "a plurality of radial bores extending from said radial-exterior surface of said sealing member to said radial-interior surface thereof; and, c. providing a pressurized sealing fluid to said inlet formed in said fixed stator, wherein said pressurized sealing fluid travels through said inlet to said pin recess formed in said floating stator, through said pin recess to said sealing member, and through said plurality of radial bores formed in said sealing member to form a pressurized fluid barrier between said radial-interior surface of said sealing member and said shaft.", "2.The method according to claim 1 wherein said plurality of radial bores is further defined as 16 radial bores evenly spaced about the periphery of said sealing member.", "3.The method according to claim 1 wherein said plurality of radial bores is further defined as being arranged in corresponding pairs, and wherein said plurality of radial bores are evenly spaced about the periphery of said sealing member.", "4.The method according to claim 1 wherein said plurality of radial bores is further defined as being unevenly spaced about the periphery of said sealing member.", "5.The method according to claim 1 wherein said fixed stator further comprises an inlet, and wherein said pressurized sealing fluid is provided to said inlet.", "6.The method according to claim 5 wherein said floating stator further comprises a fluid conduit, wherein said fluid conduit is in fluid communication with both said inlet and said spherical interface.", "7.The method according to claim 6 wherein said fluid conduit in said floating stator is further defined as being a second pin recess.", "8.The shaft seal assembly according to claim 7 wherein said pin recess further comprises a pin recess enlarged portion on a radially inward portion thereof adjacent said sealing member.", "9.The method according to claim 1 wherein said sealing member further comprises a recess formed in said radial-exterior surface thereof, wherein said recess does not extend to said radial-interior surface of said sealing member.", "10.The method according to claim 9 further comprising a pin, wherein a first portion of said pin is positioned in said pin recess and a second portion of said pin is positioned in said recess.", "11.The shaft seal assembly according to claim 1, wherein said annular recess is defined by a first and a second radially oriented surface and a circumferential axially oriented surface.", "12.The shaft seal assembly according to claim 11 wherein said fixed stator is further defined as comprising a main body and a face plate, wherein said face plate is selectively engageable with said main body, and wherein an interior surface of said face plate forms said first radially oriented surface of said annular recess.", "13.The shaft seal assembly according to claim 12 wherein said face plate is further defined as having a face plate pin recess formed in said interior surface thereof.", "14.The shaft seal assembly according to claim 13 wherein said face plate is further defined as having a face plate seal groove formed in said interior surface thereof, wherein a seal is positioned in said face plate seal groove.", "15.The shaft seal assembly according to claim 14 wherein said floating stator is further defined as having a floating stator seal groove formed in said radial-interior surface thereof, wherein a seal is positioned in said floating stator seal groove." ], [ "<SOH> FIELD OF THE INVENTION <EOH>The present invention relates to a shaft seal assembly with multiple embodiments.", "In certain embodiments, the shaft seal assembly may be used as a product seal between a product vessel and a shaft therein." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>In order that the advantages of the invention will be readily understood, a more particular description of the invention briefly described above will be rendered by reference to specific embodiments illustrated in the appended drawings.", "Understanding that these drawings depict only typical embodiments of the invention and are not therefore to be considered limited of its scope, the invention will be described and explained with additional specificity and detail through the use of the accompanying drawings.", "FIG.", "1 is a perspective exterior view of the shaft seal assembly.", "FIG.", "2 is an exterior end view of the shaft seal assembly with the shaft element aligned.", "FIG.", "3 is a sectional view of a first embodiment of the shaft seal assembly, as shown in FIG.", "2 and mounted to a housing.", "FIG.", "3A illustrates the first surface seal-shaft integrity during angular and radial shaft alignment.", "FIG.", "3B illustrates second surface seal-shaft integrity during angular and radial shaft alignment.", "FIG.", "4 is an exterior end view with the shaft misaligned.", "FIG.", "5 is a sectional view of the first embodiment as shown in FIG.", "3 with both angular and radial misalignment of the shaft applied.", "FIG.", "5A illustrates first seal-shaft integrity allowed by articulation during angular and radial shaft misalignment.", "FIG.", "5B illustrates second seal-shaft integrity allowed by articulation during angular and radial shaft misalignment.", "FIG.", "6 is a sectional view of a second embodiment of the shaft seal assembly as shown in FIG.", "2 .", "FIG.", "7 is a sectional view of a third embodiment as shown in FIG.", "2 .", "FIG.", "8 is a perspective view of a fourth embodiment as mounted to a vessel wall.", "FIG.", "9 is a cross-sectional view of a first embodiment of the pressure balanced shaft seal assembly mounted to a housing wherein the shaft is in alignment.", "FIG.", "9A is a detailed view of the portion of the first embodiment of the pressure balanced shaft seal assembly adjacent the vent wherein the shaft is in alignment.", "FIG.", "9B is a detailed view of the portion of first embodiment of the pressure balanced shaft seal assembly adjacent the fluid return pathway wherein the shaft is in alignment.", "FIG.", "10 is a cross-sectional view of the first embodiment of the pressure balanced shaft seal assembly shown during shaft misalignment.", "FIG.", "10A is a detailed view of the portion of the first embodiment of the pressure balanced shaft seal assembly adjacent the vent wherein the shaft is misaligned.", "FIG.", "10B is a detailed view of the portion of the first embodiment of the pressure balanced shaft seal assembly adjacent the fluid return pathway wherein the shaft is misaligned.", "FIG.", "11 is a cross-sectional view of a second embodiment of the pressure balanced shaft seal assembly wherein the shaft is in alignment.", "FIG.", "12 is a cross-sectional view of a third embodiment of the pressure balanced shaft seal assembly wherein the shaft is in alignment.", "FIG.", "13 is a cross-sectional view of another embodiment of a bearing isolator (or shaft seal assembly) configured with a rotor.", "FIG.", "14 is a cross-sectional view of a portion of yet another embodiment of a bearing isolator (or shaft seal assembly) configured with a rotor.", "FIG.", "14A is a cross-sectional view of the portion of the embodiment of a bearing isolator shown in FIG.", "14 with the shaft misaligned and/or radially displaced.", "FIG.", "15 is a partial cross-sectional view of the embodiment of a bearing isolator shown in FIG.", "13 wherein the shaft is misaligned and/or radially displaced.", "FIG.", "15A is a detailed view of a portion of the embodiment bearing isolator shown in FIG.", "15 .", "FIG.", "16A is an exterior face view of an illustrative embodiment of a multi-hole shaft seal assembly, wherein certain hidden surfaces are shown with broken lines.", "FIG.", "16B is a cross-sectional view of the embodiment of a multi-hole shaft seal assembly shown in FIG.", "16A along line A-A.", "FIG.", "17A is an exterior face view of one embodiment of a sealing member that may be used with various embodiments of a multi-hole shaft seal assembly.", "FIG.", "17B is a cross-sectional view of the embodiment of a sealing member shown in FIG.", "17A along line K-K. detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS REFERENCE TO RELATED APPLICATIONS Applicant Inpro/Seal LLC, a limited liability company organized under the laws of the state of Delaware and the United States of America, states that this application is a continuation of U.S. patent application Ser.", "No.", "15/026,205 filed on Mar.", "30, 2016, which application was filed as an entry into the National Phase in the United States, claimed the filing benefit of, and was based on PCT Patent Application assigned serial number PCT/US2014/058325, filed on Sep. 30, 2014, which claimed priority from provisional U.S. Pat.", "App.", "No.", "61/884,880 filed on Sep. 30, 2013, all of which are incorporated by reference herein in their entireties.", "FIELD OF THE INVENTION The present invention relates to a shaft seal assembly with multiple embodiments.", "In certain embodiments, the shaft seal assembly may be used as a product seal between a product vessel and a shaft therein.", "STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT No federal funds were used to create or develop the invention herein.", "REFERENCE TO SEQUENCE LISTING, A TABLE, OR A COMPUTER PROGRAM LISTING COMPACT DISK APPENDIX N/A BRIEF DESCRIPTION OF THE DRAWINGS In order that the advantages of the invention will be readily understood, a more particular description of the invention briefly described above will be rendered by reference to specific embodiments illustrated in the appended drawings.", "Understanding that these drawings depict only typical embodiments of the invention and are not therefore to be considered limited of its scope, the invention will be described and explained with additional specificity and detail through the use of the accompanying drawings.", "FIG.", "1 is a perspective exterior view of the shaft seal assembly.", "FIG.", "2 is an exterior end view of the shaft seal assembly with the shaft element aligned.", "FIG.", "3 is a sectional view of a first embodiment of the shaft seal assembly, as shown in FIG.", "2 and mounted to a housing.", "FIG.", "3A illustrates the first surface seal-shaft integrity during angular and radial shaft alignment.", "FIG.", "3B illustrates second surface seal-shaft integrity during angular and radial shaft alignment.", "FIG.", "4 is an exterior end view with the shaft misaligned.", "FIG.", "5 is a sectional view of the first embodiment as shown in FIG.", "3 with both angular and radial misalignment of the shaft applied.", "FIG.", "5A illustrates first seal-shaft integrity allowed by articulation during angular and radial shaft misalignment.", "FIG.", "5B illustrates second seal-shaft integrity allowed by articulation during angular and radial shaft misalignment.", "FIG.", "6 is a sectional view of a second embodiment of the shaft seal assembly as shown in FIG.", "2.FIG.", "7 is a sectional view of a third embodiment as shown in FIG.", "2.FIG.", "8 is a perspective view of a fourth embodiment as mounted to a vessel wall.", "FIG.", "9 is a cross-sectional view of a first embodiment of the pressure balanced shaft seal assembly mounted to a housing wherein the shaft is in alignment.", "FIG.", "9A is a detailed view of the portion of the first embodiment of the pressure balanced shaft seal assembly adjacent the vent wherein the shaft is in alignment.", "FIG.", "9B is a detailed view of the portion of first embodiment of the pressure balanced shaft seal assembly adjacent the fluid return pathway wherein the shaft is in alignment.", "FIG.", "10 is a cross-sectional view of the first embodiment of the pressure balanced shaft seal assembly shown during shaft misalignment.", "FIG.", "10A is a detailed view of the portion of the first embodiment of the pressure balanced shaft seal assembly adjacent the vent wherein the shaft is misaligned.", "FIG.", "10B is a detailed view of the portion of the first embodiment of the pressure balanced shaft seal assembly adjacent the fluid return pathway wherein the shaft is misaligned.", "FIG.", "11 is a cross-sectional view of a second embodiment of the pressure balanced shaft seal assembly wherein the shaft is in alignment.", "FIG.", "12 is a cross-sectional view of a third embodiment of the pressure balanced shaft seal assembly wherein the shaft is in alignment.", "FIG.", "13 is a cross-sectional view of another embodiment of a bearing isolator (or shaft seal assembly) configured with a rotor.", "FIG.", "14 is a cross-sectional view of a portion of yet another embodiment of a bearing isolator (or shaft seal assembly) configured with a rotor.", "FIG.", "14A is a cross-sectional view of the portion of the embodiment of a bearing isolator shown in FIG.", "14 with the shaft misaligned and/or radially displaced.", "FIG.", "15 is a partial cross-sectional view of the embodiment of a bearing isolator shown in FIG.", "13 wherein the shaft is misaligned and/or radially displaced.", "FIG.", "15A is a detailed view of a portion of the embodiment bearing isolator shown in FIG.", "15.FIG.", "16A is an exterior face view of an illustrative embodiment of a multi-hole shaft seal assembly, wherein certain hidden surfaces are shown with broken lines.", "FIG.", "16B is a cross-sectional view of the embodiment of a multi-hole shaft seal assembly shown in FIG.", "16A along line A-A.", "FIG.", "17A is an exterior face view of one embodiment of a sealing member that may be used with various embodiments of a multi-hole shaft seal assembly.", "FIG.", "17B is a cross-sectional view of the embodiment of a sealing member shown in FIG.", "17A along line K-K.", "DETAILED DESCRIPTION Element Listing (FIGS.", "1-12) Description Element No.", "Shaft 1 Fixed stator 2 Fixed stator (part-line) 2a Labyrinth seal 3 Radiused face 3a Floating stator 4 Fluid return pathway 5 Shaft seal clearance 6 First o-ring 7 Anti-rotation pin 8 Vent 9 Anti-rotation groove (floating stator) 10 Spherical interface 11 Anti-rotation pin 12 Second o-ring 13 Labyrinth seal pattern grooves 14 First o-ring channel 15 Cavity for anti-rotation device (fixed stator) 16 Axial face of labyrinth seal 17 Axial face of floating stator 18 Second o-ring channel 19 First clearance between floating stator/fixed stator 20 Second clearance between floating stator/fixed stator 21 Throttle groove 22 Labyrinth pattern annular groove 23 Sleeve 24 Shaft seal assembly 25 Throttle (alignment skate) 26 Floating stator annular groove 27 Labyrinth seal passage 28 Floating stator passage 29 Housing 30 Angle of misalignment 31 Bearings and bearing cavity 32 Mounting bolts 33 Vessel wall 34 Pressure balanced shaft seal assembly 40 Labyrinth seal interior face 42 Floating stator interior face 44 Pressure balancing annular channel 46 First radial interface 47a Second radial interface 47b Fixed stator annular groove 48 Annular groove radial-interior surface 48a Detailed Description Before the various embodiments of the present invention are explained in detail, it is to be understood that the invention is not limited in its application to the details of construction and the arrangements of components set forth in the following description or illustrated in the drawings.", "The invention is capable of other embodiments and of being practiced or of being carried out in various ways.", "Also, it is to be understood that phraseology and terminology used herein with reference to device or element orientation (such as, for example, terms like “front”, “back”, “up”, “down”, “top”, “bottom”, and the like) are only used to simplify description of the present invention, and do not alone indicate or imply that the device or element referred to must have a particular orientation.", "In addition, terms such as “first”, “second”, and “third” are used herein and in the appended claims for purposes of description and are not intended to indicate or imply relative importance or significance.", "Furthermore, any dimensions recited or called out herein are for exemplary purposes only and are not meant to limit the scope of the present disclosure in any way unless so recited in the claims.", "FIGS.", "1-5 provide various views of a first illustrative embodiment of the shaft seal assembly 25 that allows for sealing various lubricating solutions within bearing housing 30 and/or preventing ingress of contaminants to the housing 30, which may be configured as a bearing housing.", "FIGS.", "6 and 7 provide alternative illustrative embodiments of the shaft seal assembly 25 wherein sealing fluids are used.", "Applicant herein defines sealing fluids to include at least both liquids and vapors.", "Applicant considers air, nitrogen, water and steam as well as any other fluid that may work with the proposed shaft seal assembly to provide a pressurized fluid barrier for any and all embodiments disclosed herein to be within the purview of the present disclosure.", "The gas or fluid chosen may be based at least upon process suitability with the product to be sealed.", "FIG.", "1 is a perspective exterior view of the first illustrative embodiment of a shaft seal assembly 25 arranged and engaged with a shaft 1 inserted through the fixed stator 2 of shaft seal assembly 25.FIG.", "2 is an exterior end view of the shaft seal assembly with shaft 1 aligned within the shaft seal assembly 25.FIG.", "3 is a sectional view of a first embodiment of the shaft seal assembly 25 shown in FIG.", "2 illustrating that the shaft seal assembly 25 may be configured as a labyrinth seal for retaining lubrication solution within the bearing cavity 32 of housing 30 and/or preventing ingress of contaminants into the housing 30.The shaft 1 shown in FIG.", "3 may experience radial, angular or axial movement relative to the fixed stator 2 or a portion thereof at various times.", "The fixed stator 2 of the shaft seal assembly 25 may be engaged with a housing 30 via any suitable method and/or structure, including but not limited to flange-mounted or press-fit.", "The shaft seal assembly 25 may also be used in applications with a rotating housing and stationary shaft.", "(Not shown) As required by the particular application of the shaft 1 and/or shaft seal assembly 25, the shaft 1 may be allowed to move freely in the axial direction in relation to the shaft seal assembly 25.A labyrinth seal 3 having an interior surface may be positioned adjacent shaft 1.A defined clearance 6 may exist between the interior surface of said labyrinth seal 3 and the shaft 1.A radiused surface 3a may be configured such that it is opposite the interior surface of the labyrinth seal 3.The radiused surface 3a of the labyrinth seal 3 and the interior of the floating stator 4 may be configured to form a spherical interface 11.O-ring channels 15 and o-rings 7 may be disposed to cooperate with the radiused surface 3a of the labyrinth seal 3 to seal (or trap) fluid migration through, between and along engaged labyrinth seal 3 and floating stator 4 while maintaining a spherical interface 11, which spherical interface 11 may allow limited relative rotational movement (articulation) between labyrinth seal 3 and floating stator 4.O-ring channels 15, as shown, may be machined into the floating stator 4 and may be positioned at the spherical interface 11 with labyrinth seal 3.O-ring channels 15 may be configured such that they are annular and continuous in relation to labyrinth seal 3.The o-ring channel 15 and o-ring 7 may also be placed in the labyrinth seal 3 adjacent the spherical interface 11.In certain embodiments, o-rings 7 may be constructed of materials that are compatible with both the product to be sealed and the preferred sealing fluid.", "O-ring channels 15 and o-rings 7 are but one possible combination of structures that may be used to seal various potions within the shaft seal assembly 25.Any other structures and/or method suitable for the particular embodiment of a shaft seal assembly 25 may be used without limitation.", "Strategically placed anti-rotation pin(s) 12 may be inserted into anti-rotation grooves 10 and may serve to limit relative rotational movement between labyrinth seal 3 and floating stator 4.A plurality of anti-rotation grooves 10 and pins 12 may be placed around the radius of the shaft 1.If the shaft seal assembly 25 is used in combination with a sealing fluid, strategic anti-rotation pins 12 may be removed allowing corresponding anti-rotation grooves 10 to serve as a fluid passage through vent 9 and lubricant return 5, one illustrative embodiment of which is shown in FIG.", "7.Additionally, the relationship of the diameters of anti-rotation pins 12 and anti-rotation grooves 10 may be selected to allow more or less angular misalignment of the shaft 1, respectively.", "For example, a relatively small-diameter anti-rotation pin 12 used with a large-diameter anti-rotation groove 10 would allow for greater relative movement of the labyrinth seal 3 in relation to the floating stator 4 in response to angular misalignment of shaft 1.A labyrinth seal 3 is one possible embodiment of a sealing structure that may be used adjacent to the shaft 1 within the shaft seal assembly 25.However, other structures and/or methods may be used to achieve similar functionality without limitation.", "An annular channel may be formed within fixed stator 2 and may be defined by clearance 20 and 21 as allowed between the exterior of said floating stator 4 and the interior of the fixed stator 2 of shaft seal assembly 25.The annular channel of fixed stator 2 is highlighted as A-A′ in FIG.", "2.The annular channel of the fixed stator 2 may be formed with interior surfaces that are configured such that they are substantially perpendicular to said shaft 1.The exterior surfaces of the floating stator 4, which may be substantially encompassed within the annular channel of the fixed stator 2, may cooperatively engage with the first and second interior perpendicular faces of the fixed stator 2.An inner interface may be formed by the first (shaft seal assembly 25 inboard side) perpendicular annular channel surface of the fixed stator 2 engaging with the first (inboard side) perpendicular face of the floating stator 4.An outer interface may be formed by the second (shaft seal assembly 25 outboard side) perpendicular annular interior channel surface of the fixed stator 2 engaging with the second (outboard side) perpendicular face of the floating stator 4.O-ring channels 19 and o-rings 13 may be disposed therein and may cooperate with the surfaces of floating stator 4 that are in perpendicular to relation to shaft 1.These o-rings 13 may function to seal (or trap) fluid migration between and along engaged floating stator 4 while allowing limited relative rotational movement between floating stator 4 and fixed stator 2.Floating stator 4 and fixed stator 2 are one possible embodiment of cooperatively engaged portions of a shaft seal assembly 25 that may be configured to allow relative motion between the portions in at least one dimension, and which may be used in combination with labyrinth seal 3 within the shaft seal assembly 25.However, other structures and/or methods may be used to achieve similar functionality without limitation.", "O-ring channels 19 may be configured such that they are annular and continuous in relation to shaft 1.In an embodiment not shown herein, the o-ring channels 19 and o-rings 13 may be placed in the body of the floating stator 4 rather than the fixed stator 2.It is contemplated that for many applications it may be optimal to place those o-ring channels 19 and corresponding o-rings 13 in similar proximal relation.", "In certain embodiments, o-rings 7 may be constructed of materials that are compatible with both the product to be sealed and the preferred sealing fluid.", "O-ring channels 15 and o-rings 7 are but one possible combination of structures that may be used to seal various potions within the shaft seal assembly 25.Any other structures and/or method suitable for the particular embodiment of a shaft seal assembly 25 may be used without limitation.", "Strategically placed anti-rotation pin(s) 8 may be inserted into anti-rotation groove(s) 16 and may serve to limit both relative radial and rotational movement between floating stator 4 and interior side of fixed stator 2.A plurality of anti-rotation grooves 16 and pins 8 may be placed around the radius of the shaft 1.The relationship of the diameters of anti-rotation pins 8 and anti-rotation grooves 16 may also be selected to allow more or less angular misalignment of the shaft.", "For example, a small-diameter anti-rotation pin 8 and large-diameter fixed stator anti-rotation groove may allow for greater relative movement of the labyrinth seal 3 in response to angular misalignment of shaft 1.The labyrinth pattern seal grooves 14 may be pressure equalized by venting through one or more vents 9.If so desired, the vents 9 may be supplied with a pressurized sealing fluid such that the sealing fluid over-pressurizes the labyrinth area 14 and shaft seal clearance 6 to increase the efficacy of shaft seal assembly 25.A spherical interface 11 between the labyrinth seal 3 and the floating stator 4 may be configured to allow for angular misalignment between the shaft 1 and fixed stator 2.O-ring channels 19 are annular with the shaft 1 and, as shown, may be machined into the fixed stator 2 and positioned at the interface between the fixed stator 2 and floating stator 4.O-ring channel 19 may also be placed in the floating stator 4 and may be engaged with o-rings 13, which may be configured to provide sealing contact with the fixed stator 2.FIG.", "3A illustrates seal-shaft integrity during angular and radial shaft 1 alignment.", "This view highlights the alignment of the axial face 17 of the labyrinth seal 3 and the axial face 18 of the floating stator 4.Particular focus is drawn to the alignment of the axial faces 17, 18 at the spherical interface 11 between the floating stator 4 and labyrinth 3.FIG.", "3B illustrates the shaft-seal integrity during angular and radial shaft 1 alignment at the surface opposite that shown in FIG.", "3A.", "This view highlights the alignment of the axial faces 17, 18 of labyrinth seal 3 and floating stator 4, respectively, for the opposite portion of the shaft seal assembly 25 as shown in FIG.", "3A.", "Those of ordinary skill in the art will appreciate that because the shaft 1 and the illustrative embodiments of a shaft seal assembly 25 are of a circular shape and nature, the surfaces are shown 360 degrees around shaft 1.Again, particular focus is drawn to the alignment of the axial faces 17, 18 at the spherical interface 11 between the labyrinth seal 3 and floating stator 4.FIGS.", "3A and 3B also illustrate the first defined clearance 20 between the floating stator 4 and the fixed stator 2 and the second defined clearance 21 between the floating stator 4 and fixed stator 2 and opposite the first defined clearance 20.In FIGS.", "2, 3, 3A and 3B, the shaft 1 is not experiencing radial, angular or axial movement with respect to a housing 30.Accordingly, in the illustrative embodiments the width of the defined clearances 20 and 21, which may be substantially equal, may indicate little movement or misalignment upon the floating stator 4.FIG.", "4 is an exterior end view of the shaft seal assembly 25 with the rotatable shaft 1 misaligned therein.", "FIG.", "5 is a sectional view of the first embodiment of the shaft seal assembly 25 as shown in FIG.", "3 with both angular and radial misalignment of the shaft 1 applied.", "The shaft 1 as shown in FIG.", "5 is also of the type that may experience radial, angular or axial movement relative to the fixed stator 2 (and/or housing 30) of the shaft seal assembly 25.As shown at FIG.", "5, the defined radial clearance 6 of labyrinth seal 3 with shaft 1 may be maintained even though the angle of shaft misalignment 31 has changed.", "The shaft 1 still may be allowed to move freely in the axial direction even though the angle of shaft misalignment 31 has changed.", "The arrangement of the shaft seal assembly 25 may allow the labyrinth seal 3 to move with the floating stator 4 upon introduction of radial movement of said shaft 1.The labyrinth seal 3 and floating stator 4 may be secured together by one or more compressed o-rings 7 or any other suitable structure and/or method.", "Rotation of the labyrinth seal 3 within the floating stator 4 may be prevented by anti-rotation members, which may include but are not limited to screws, anti-rotation pins 8, or similar devices to inhibit rotation.", "The pins as shown in FIGS.", "3, 3A, 3B, 5, 6 and 7 are one structure for preventing rotation of the labyrinth seal 3 and floating stator 4.However, any other suitable structure and/or method may be used to achieve similar results without limitation.", "Lubricant, sealing fluid, or other media may be collected and drained through a series of one or more optional drains or lubricant return pathways 5.The labyrinth seal 3 may be pressure-equalized by venting through one or more vents 9.If so desired, the vents 9 may be supplied with pressurized air or other gas or fluid media to over-pressurize the labyrinth seal 3 to increase seal efficacy.", "The combination of close tolerances between the cooperatively engaged mechanical portions of the shaft seal assembly 25 and pressurized sealing fluid may inhibit both product and contaminant contact with the internals of the shaft seal assembly 25.The spherical interface 11 between the labyrinth seal 3 and the floating stator 4 may be configured to allow for angular misalignment between the shaft 1 and fixed stator 2.O-ring channel 19 and o-ring 13, which may be disposed therein, may cooperate with the opposing faces of the floating stator 4, which may be configured such that they are substantially in perpendicular relation to the rotational axis of the shaft 1.In this manner, the o-rings 13 may cooperate with the floating stator 4 to seal (or trap) fluid migration between and along the floating stator 4 while allowing relative radial movement between stator 4 and fixed stator 2.FIG.", "5A illustrates seal-shaft integrity allowed by the shaft seal assembly 25 during angular and radial shaft 1 misalignment.", "This view highlights the offset or articulation of the axial faces 17 of the labyrinth seal 3 may have in relation the axial faces 18 of the floating stator 4 for a first portion of the shaft seal assembly 25.Particular focus is drawn to the offset of the axial faces 17, 18 at the spherical interface 11 between labyrinth seal 3 and floating stator 4.FIG.", "5B illustrates seal-shaft integrity for a second surface, opposite the first surface shown in FIG.", "5A, during angular and radial shaft misalignment.", "This view highlights that during misalignment of shaft 1, axial faces 17, 18, of the labyrinth seal 3 and floating stator 4, respectively, may not be aligned but instead move (articulate) in relation to each other.", "The shaft-to-seal clearance 6 may be maintained in response to the shaft 1 misalignment and the overall seal integrity may not be compromised because the seal integrity of the floating stator 4 to fixed stator 2 and the floating stator 4 to labyrinth seal 3 may be maintained during shaft 1 misalignment.", "Those of ordinary skill in the art will appreciate that because the shaft 1 and shaft seal assembly 25 may be circular in shape and nature, the surfaces are shown 360 degrees around shaft 1.FIGS.", "5A and 5B also illustrate the first clearance or gap 20 between the floating stator 4 and the fixed stator 2 and the second clearance or gap 21 between the floating stator 4 and fixed stator 2 and opposite the first clearance or gap 20 during relative movement (other than rotational) between the shaft 1 and the housing 30.In FIGS.", "4, 5, 5A and 5B, the shaft 1 is experiencing radial, angular, or axial movement during rotation of the shaft 1 and the width of the gaps or clearances 20, 21 are shown as having changed in response to that movement as compared to the gaps or clearances 20, 21 depicted in FIGS.", "3, 3A and 3B.", "The change in dimensions of clearance 20, 21 indicate the floating stator 4 may move in response to the movement or angular misalignment of shaft 1.The shaft seal assembly 25 may allow articulation between axial faces 17, 18, maintenance of spherical interface 11 and radial movement at first and second clearance, 20, 21, respectively, while maintaining shaft seal clearance 6.FIG.", "6 is a sectional view of a second embodiment of the shaft seal assembly 25 as shown in FIG.", "2 for over-pressurization with alternative labyrinth seal pattern grooves 14.In this embodiment, the labyrinth seal pattern grooves 14 may be comprised of a friction-reducing substance such as polytetrafluoroethylene (PTFE), wherein the friction-reducing substance may be configured such that it forms a close clearance to the shaft 1.PTFE is also sometimes referred to as Teflon®, which is manufactured and marketed by Dupont.", "PTFE is a plastic with high chemical resistance, low and high temperature capability, resistance to weathering, low friction, electrical and thermal insulation, and high lubricity.", "Carbon or any other materials without limitation may be substituted for PTFE to provide the necessary sealing qualities and lubricous qualities for labyrinth seal pattern grooves 14.Pressurized sealing fluids may be supplied to over-pressurize the lubricious labyrinth pattern 26 as shown in FIG.", "6.The pressurized sealing fluids may be introduced to the annular groove 23 of the throttle 26 through one or more inlets.", "Throttle 26 may also be referred to as “an alignment skate” by those of ordinary skill in the art.", "Throttle 26 may allow the labyrinth seal 3 to respond to movement of the shaft 1 caused by the misalignment of the shaft 1.The pressurized sealing fluid may pass through the close clearance formed between the shaft 1 and labyrinth seal 3 having throttle 26.The close proximity of the throttle 26 to the shaft 1 also may create resistance to the sealing fluid flow over the shaft 1 and may cause pressure to build up inside the annular groove 23.Floating annular groove 27 in cooperation and connection with annular groove 23 also may provide an outlet for excess sealing fluid to be bled out of shaft seal assembly 25 for pressure equalization or to maintain a continuous fluid purge on the shaft sealing assembly 25 during operation.", "An advantage afforded by this aspect of the shaft sealing assembly 25 is its application wherein “clean-in place” product-seal decontamination procedures are preferred or required.", "Examples would include food grade applications.", "FIG.", "7 illustrates shaft seal assembly 25 with the anti-rotation pin 12 removed to improve visualization of the inlets.", "These would typically be comprised of, but are not limited to, a series of ports, inlets or passages about the circumference of the shaft seal assembly 25.FIG.", "7 also illustrates that the shape and pattern of the labyrinth seal 3 may be varied from one embodiment of the shaft seal assembly 25 to the next.", "The shape of throttles 26 may also be varied as shown by the square profile shown at throttle groove 22 in addition to the circular-type 26.Also note that where direct contact with the shaft 1 is not desired, the shaft seal assembly 25 may be used in combination with a separate sleeve 24 that would be attached by varied means to the shaft 1.FIG.", "8 shows that another embodiment of the shaft seal assembly 25 wherein the shaft seal assembly 25 has been affixed to a vessel wall 34.The shaft seal assembly 25 may be affixed to vessel wall 34 through securement members (e.g., including but not limited to mounting bolts 33) to ensure improved sealing wherein shaft 1 is subjected to angular misalignment.", "The mounting bolts 33 and slots (not numbered) through the shaft seal assembly 25 exterior are one structure and method of mounting the shaft seal assembly 25 to a housing 30.However, any suitable structure and/or method may be used without limitation.", "In certain applications, especially those wherein the process side of shaft seal assembly 25 (generally the area to the left of the shaft seal assembly 25 as shown in FIGS.", "3-3B and 5-7) is at an increased pressure, it is desirable for the shaft seal assembly 25 to be configured to balance the pressure experienced by the shaft seal assembly 25 in the axial direction.", "A pressure balanced shaft seal assembly 40 that balances the pressure (in the axial direction) that the product applies to the labyrinth seal interior face 42 and floating stator interior face 44 is shown in FIGS.", "9-12.In the first embodiment of the pressure balanced shaft seal assembly as shown in FIGS.", "9-10B, the shaft sealing member (i.e., the labyrinth seal 3 in combination with the floating stator 4) includes a pressure balancing annular channel 46.Save for the pressure balancing annular channel 46, the pressure balanced shaft seal assembly 40 may operate in generally the same manner as the shaft seal assembly 25 shown in FIGS.", "1-8 and described in detail above.", "That is, the floating stator 4 may be positioned in the fixed stator annular groove 48.The first clearance between floating stator/fixed stator 20, which in the embodiments pictured herein may be between the floating stator radial-exterior surface 45 and the annular groove radial-interior surface 48a (shown in FIGS.", "9A and 9B), may account at least for radial perturbations of the shaft 1 with respect to the housing 30.The spherical interface 11 between the floating stator 4 and the labyrinth seal 3 may account at least for angular perturbations of the shaft 1 with respect to the housing 30.The pressure balancing annular channel 46 may be formed in the floating stator 4 adjacent the first radial interface 47a between the floating stator 4 and the fixed stator 2, as shown in FIGS.", "9-10 for the first embodiment.", "As shown in the various embodiments pictured herein, the first radial interface 47a between the floating stator 4 and the fixed stator 2 may be adjacent the portion of the fixed stator 2 fashioned with the cavity for anti-rotation device 16.That is, the axial face of the floating stator 4 that is positioned within the fixed stator 2 and furthest from the process side of the pressure balanced shaft seal assembly 40.A second radial interface 47b between the floating stator 4 and fixed stator 2, which may be substantially parallel to the first radial interface 47a, may be positioned closer to the process side of the pressure balanced shaft seal assembly 40 as compared to the first radial interface 47a.", "In many applications the optimal radial dimension of the pressure balancing annular channel 46 may be substantially similar to the radial dimension of the floating stator interior face 44 so that the area of the floating stator 4 acted upon by the product and the area of the floating stator 4 acted upon by the sealing fluid may have relatively equal surface areas.", "In such a configuration, the axial forces may generally balance if the product and the sealing fluid are pressurized to approximately the same value.", "Accordingly, the optimal radial dimension of the pressure balancing annular channel 46 may depend on the design characteristics of the entire system, and the radial dimension of the pressure balancing annular channel 46 may be any suitable amount for a particular application, whether greater or less than the radial dimension of the floating stator interior face 44.The axial dimension of the pressure balancing annular channel 46 may also vary depending on the design characteristics of the entire system, including but not limited to the specific sealing fluid that is used, the product pressure, and the pressure of the sealing fluid.", "In some applications the optimal axial dimension of the pressure balancing annular channel 46 will be 0.005 of an inch, but may be greater in other embodiments and less in still other embodiments.", "The pressure balancing annular channel 46 may allow sealing fluid introduced into the first clearance between floating stator/fixed stator 20 (from where the sealing fluid may enter the pressure balancing annular channel 46) to act upon the floating stator 4 in an axial direction.", "Typically, the process side of the pressure balanced shaft seal assembly 40 (generally the area to the left of the pressure balanced shaft seal assembly 40 as shown in FIGS.", "9-12) experiences forces from the process fluid acting upon the labyrinth seal interior face 42 and floating stator interior face 44.These forces are most often due to the pressure generated by the rotating equipment to which the shaft 1 is coupled.", "For example, if the shaft 1 is coupled to a fluid pump generating seventy pounds per square inch (psi) of head pressure, the process side of the pressure balanced shaft seal assembly 40 may be pressurized to approximately 70 psi.", "This pressurized fluid may act upon the labyrinth seal interior face 42 and floating stator interior face 44, and consequently urge the labyrinth seal 3 and floating stator 4 in the axial direction away from the process side of the pressure balancing shaft seal assembly 40 (i.e., generally to the right side of the drawing as depicted in FIGS.", "9-12).", "By contrast, sealing fluid located in the pressure balancing annular channel 46 may urge the labyrinth seal 3 and floating stator 4 in the axial direction toward the process side of the pressure balancing shaft seal assembly 40, which may substantially cancel the axial force the product exerts upon the pressure balancing shaft seal assembly 40, depending on the design of the sealing fluid system.", "FIGS.", "11 and 12 show a second and third embodiment of the pressure balanced shaft seal assembly 40, respectively.", "The second and third embodiments of the pressure balanced shaft seal assembly 40 generally correspond to the second and third embodiments of the shaft seal assembly 25 as shown in FIGS.", "7 and 8 and described in detail above.", "However, as with the first embodiment of the pressure balanced shaft seal assembly 40 as shown in FIGS.", "9-10B, the second and third embodiments include a pressure balancing annular channel 46.The various embodiments of the pressure balanced shaft seal assembly 40 pictured and described herein may be formed with a fixed stator 2 and floating stator 4 that may be comprised of two distinct portions.", "These embodiments may facilitate assembly of the pressure balanced shaft seal assembly 40 since in the embodiments pictured herein the majority of the floating stator 4 may be positioned within the fixed stator 2.When installing a pressure balanced shaft seal assembly 40 according to the first embodiment (as pictured in FIGS.", "9-10B), the first portion of fixed stator 2 (i.e., the portion adjacent the process side of the pressure balanced shaft seal assembly 40) may be affixed to a housing 30.Next, the floating stator 4 and labyrinth seal 3 may be positioned as a singular assembled piece (wherein the components forming the spherical interface 11 have been preassembled) between the shaft 1 and the first portion of the fixed stator 2.The placement of the floating stator 4 and labyrinth seal 3 within the fixed stator 3 may forms the second axial interface 47b between the fixed stator 2 and floating stator 4.Finally, the second portion of the fixed stator 2 (i.e., the portion furthest from the process side of the pressure balanced shaft seal assembly 40) may be positioned adjacent to and affixed to the first portion of the fixed stator 2.The positioning of the second portion of the fixed stator 2 subsequently may form the first radial interface 47a between the fixed stator 2 and floating stator 4.Alternatively, the floating stator 4 and labyrinth seal 3 may be separately positioned within the fixed stator annular groove 48.For example, after the first portion of the fixed stator 2 has been affixed to the housing 30, the first portion of the floating stator 4 may be positioned within the fixed stator annular groove 48.The placement of the first portion of the floating stator 4 within the fixed stator annular groove 48 may form the second axial interface 47b between the fixed stator 2 and floating stator 4.Next, the labyrinth seal 3 may be positioned adjacent the shaft 3, the placement of which may form a portion of the spherical interface 11 between the floating stator 4 and labyrinth seal 3.Next, the second portion of the floating stator 4 may be positioned adjacent the first portion of the floating stator 4 and affixed thereto with a plurality of anti-rotation pins 8, which may complete the spherical interface 11 between the floating stator 4 and labyrinth seal 3.Finally, the second portion of the fixed stator 2 may be affixed to the first portion of the fixed stator 2 with a plurality of bolts, rivets, or other fasteners without limitation, the placement of which may form the first axial interface 47a between the floating stator 4 and fixed stator 2.Any suitable securing members known to those skilled in the art may be used to affix the first and second portions of the floating stator 4 to one another or to affix the first and second portions of the fixed stator 2 to one another in any embodiments of a shaft seal assembly 25 or pressure balanced shaft seal assembly 40 without limitation.", "Element Listing (FIGS.", "13-15A) Description Element No.", "Shaft 10 Bearing isolator 18 Housing 19 Rotor 20 Stator 30, 31a Fixed stator 31 Passage 40, 40a Spherical surface 50, 51 Clearance 52 Frictional seal 60 Flange unit 61a Center point 80 Conduit 99 Fluid 100 Pin 101 Annular recess 102 FIG.", "13 shows another embodiment of a bearing isolator 18 (or shaft seal assembly) mounted adjacent a shaft 10.The shaft 10 may extend through the bearing isolator 18 and/or the housing 19.A source of gas or fluid, 100 which may include but is not limited water, gas, vapor and/or lubricant, may also be in communication with the bearing isolator 18 via conduit 99.The rotor 20 may be affixed to the shaft 10 by means by a frictional seal 60, which may be configured as one or more o-rings.", "The rotor 20 may be configured to follow the rotational movement of the shaft 10 because of the frictional engagement of the seals 60.The passages 40 and 40a may be configured as shown but will not be described in detail here because such description is already understood by those of ordinary skill in the art.", "A pair of corresponding spherical surfaces 50 and 51 may be used to create a self-aligning radial clearance 52 between the rotor 20 and the stator 30 prior to, during, and after use.", "This clearance 52 may be maintained at a constant value even as the shaft 10 becomes misaligned during use.", "Various amounts and direction of misalignment between the centerline of the shaft 10 and the housing 19 are illustrated in FIGS.", "15-17.An annular recess 102 between the stator 30 and fixed stator 31 may allow the bearing isolator 18 to accommodate a predetermined amount of radial shaft displacement.", "In the embodiments shown herein, the spherical surfaces 50, 51 may have a center point identical from the axial faces of both the rotor and stator 20, 30, respectively.", "However, the spherical surfaces 50, 51 may be radially, and/or as shown, vertically spaced apart.", "These spherical surfaces 50, 51 may move radially in response to and/or in connection with and/or in concert with the radially positioning of other components of the bearing isolator 18.Typically, if the shaft 10 becomes misaligned with respect to the housing 19, the rotor 20 may consequently become misaligned with respect thereto, and then the spherical surfaces 50, 51 and/or the stator 30, moving radially within the annular recess of the fixed stator 31, may compensate for the misalignment.", "FIGS.", "15 and 15A illustrate that in one embodiment of the bearing isolator 18, the rotor 20 may move with respect to the stator 30, 31 as shaft 10 is misaligned with respect to housing 19 through the interaction between spherical surfaces 50, 51.Such relative movement to help to ensure the distances between the center points of the rotor 20 and stator 30 and a fixed point on the housing 19 are constant or relatively constant during use.", "In the embodiment of the bearing isolator 18 shown in FIGS.", "14 and 14A, the spherical surfaces 50, 51 may be positioned on a fixed stator 31 and stator 31a, respectively, rather than on the rotor 20 and stator 30.Still referring to FIGS.", "14 and 14A, this design may allow the rotor 20 and stator 31a to move with respect to the fixed stator 31, flange unit 61a, and/or housing 19.The rotor 20, stator 31a, and fixed stator 31 may move radially with respect to the flange unit 61a (and consequently with respect to the housing 19) as best shown in FIG.", "14A.", "In this embodiment of the bearing isolator 18 there may be a very minimal amount of relative rotation between the spherical surfaces 50, 51.The embodiment of the bearing isolator 18 shown in FIGS.", "14 and 14A may provide for controlled radial movement of the fixed stator 31, stator 31a, and/or rotor 20 with respect to flange unit 61a, which flange unit 61a may be engaged with a housing 19.Rotational movement of the fixed stator 30 with respect to the flange unit 61a may be prevented by anti-rotational pins 101.The fixed stator 31 may be frictionally secured to the flange unit 61a using a frictional seal 61, which may be made of any material with sufficient elasticity and frictional characteristics to hold the fixed stator 31 in a fixed radial position with respect to the flange unit 61a but still be responsive to the radial forces when the shaft 10 is misaligned.", "Changes to the radial position of the fixed stator 31, stator 31a, and/or rotor 20 and the resulting positions thereof (as well as the resulting position of the interface between the fixed stator 31 and stator 31a) may occur until the radial force is fully accommodated or until the maximum radial displacement of the bearing isolator 18 is reached.", "Referring now to FIGS.", "15 and 15A, in operation the rotor 20 may be moved radially as the shaft 10 becomes misaligned with respect to the housing 19.Radial movement of the spherical surfaces 50, 51 between the stator 31a and fixed stator 31 may result from this pressure.", "FIG.", "15 shows potential resultant radial movement of center point 80 as the shaft 10 is misaligned.", "During normal operation, the shaft 10 is typically horizontal with respect to the orientation shown in FIG.", "15, as represented by line A.", "As the shaft 10 becomes misaligned in a manner represented by line B, the center point 80 may move to a point along line A″.", "As the shaft 10 becomes misaligned in a manner represented by line B′, the center point 80 may move to a point along line A′.", "However, in other shaft 10 misalignments, the radial positions of the rotor 20, stator 30, and/or fixed stator 31 may be constant and the spherical surfaces 50, 51 may compensate for the shaft 10 misalignment.", "From the preceding description it will be apparent that the bearing isolator 18 may provide a constant seal around the shaft 10 because the distance between the spherical surfaces 50, 51 may be maintained as a constant regardless of shaft 10 misalignment of a normal or design nature.", "The physical dimensions of the spherical surfaces 50 and 51 may vary in linear value and in distance from the center point 80, depending on the specific application of the bearing isolator 18.These variations will be utilized to accommodate different sizes of shafts and seals and different amounts of misalignment, and therefore in no way limit the scope of the bearing isolator 18 as disclosed herein.", "Additionally, and suitable structure and/or method for engaging various elements with one another either rotationally, fixedly, or with various degrees of freedom of motion therebetween may be used with the shaft seal assembly 18 without limitation, including but not limited to screws, bolts, pins, chemical adhesives, interference fits, and/or combinations thereof.", "Element Listing (FIGS.", "16-17) Description Element No.", "Shaft seal assembly 10 Shaft 12 Fastener 14 Fixed stator 20 Fixed stator seal groove 20a Main body 21 Face plate 22 Face plate pin recess 22a Face plate seal groove 22b Inlet 24 Annular recess 26 Seal 28 Floating stator 30 Floating stator seal groove 30a Radial exterior surface 32 First pin recess 33 Pin 34 Second pin recess 35 Second pin recess enlarged portion 35a Floating stator annular groove 37 Concave surface 38 Sealing member 40 Recess 42 Radial bore 44 Radial bore inlet 44a Radial bore outlet 44b Radial interior surface 46 Convex surface 48 Another embodiment of a shaft seal assembly 10 is shown in FIGS.", "16A & 16B.", "This embodiment is similar to the embodiment of the shaft seal assembly 25 described above and shown in FIGS.", "1-12.The shaft seal assembly 10 may include a fixed stator 20, floating stator 30, and a sealing member 40, as shown.", "In the pictured embodiment, the sealing member 40 may be positioned adjacent a shaft 12 that is rotatable with respect to the shaft seal assembly 10 and/or housing.", "Accordingly, a rotational interface may exist between a radial interior surface 46 of the sealing member 40 positioned adjacent the shaft 12 and an exterior portion of the shaft 12.In other embodiments of the shaft seal assembly 10 not pictured herein, the sealing member 40 may be engaged with the shaft 12 such that it rotates therewith (e.g., the shaft seal assembly 10 may be configured with a rotor).", "In such an embodiment, a rotational interface may exist between a concave surface 38 of the floating stator 30 and a convex surface 48 of the sealing member 40.Accordingly, the scope of the shaft seal assembly 10 as disclosed herein extends to shaft seal assemblies 10 in which the sealing member 40 does or does not rotate with a shaft 12.The embodiment of the shaft seal assembly 10 shown in FIGS.", "16A & 16B may include a fixed stator 20 that may be securely mounted to a housing (not shown in FIGS.", "16A & 16B) by any suitable methods and/or structure.", "The fixed stator 20 may include a main body 21 and a face plate 22 that may be engaged with one another via one or more fasteners 14.It is contemplated that a fixed stator 20 formed with a main body 21 and face plate 22 may facilitate ease of installation of the shaft seal assembly 10 in certain applications.", "In such applications, the main body 21 may be affixed to the housing, the sealing member 40 and floating stator 30 may be positioned appropriately, and then the face plate 22 may be secured to the main body 21.However, the scope of the present disclosure is in no way limited by the specific mounting and/or installation method of the shaft seal assembly 10.The fixed stator 20 may be formed with an annular recess 26 into which a portion of the floating stator 30 and/or sealing member 40 may be positioned.", "A predetermined clearance between the radial exterior surface 32 of the floating stator 30 (as well as the axial exterior surfaces thereof) and the interior surfaces of the annular recess 26 may be selected to allow for a predetermined amount of relative radial and/or axial movement between the fixed stator 20 and floating stator 30.At least one pin 34 (which may be radially oriented as in the embodiment shown in FIGS.", "16A & 16B) may be engaged with the floating stator 30 at a second pin recess 35, and a portion of the pin 34 may extend into a recess 42 formed in the sealing member 40.Additionally, other pins (not shown, but which may be axially oriented) also may be engaged with the floating stator about a first pin recess 33, and a portion of that pin may extend into a face plate pin recess 22a.", "In the illustrative embodiment shown in FIGS.", "16A & 16B, the pins 35 may mitigate relative rotation between the floating stator 30 and the sealing member 40.Axially oriented pins (not shown) may mitigate relative rotation between the floating stator 30 and the fixed stator 20.The axial interfaces between the floating stator 30 and fixed stator 20 may be sealed with seals 28, which seals 28 may be positioned in fixed stator seal grooves 20a and/or face plate seal grooves 22b.", "The seals 28 may be configured as o-rings, but may be differently configured in other embodiments of the shaft seal assembly 10 without limitation.", "The floating stator 30 may also be formed with a concave surface 38 in a radial interior portion thereof.", "This concave surface 38 may form a semi-spherical interface with a corresponding convex surface 48 formed in the radial exterior portion of the sealing member 40.Accordingly, the shaft seal assembly 10 shown in FIGS.", "16A & 16B may accommodate shaft 12 misalignment, shaft 12 radial movement, and shaft 12 axial movement with respect to the shaft seal assembly 10 and/or equipment housing in an identical and/or similar manner to that previously described for the shaft seal assemblies 25 shown in FIGS.", "1-12.The illustrative embodiment of the shaft seal assembly 10 also may include various fluid conduits for applying a sealing fluid to the shaft seal assembly 10.The fixed stator 20 may be formed with one or more inlets 24 for introduction of a sealing fluid to the shaft seal assembly 10.The inlet 24 may be in fluid communication with the annular recess 26 formed in the fixed stator 20, which annular recess 26 may be in fluid communication with one or more radial passages (not shown) formed in the floating stator 30 and extending from the radial exterior surface 32 thereof to the concave surface 38 thereof.", "Alternatively, or in addition to the one or more radial passages, the second pin recess 35 formed in the floating stator 30 may be configured to allow a specific amount of sealing fluid to traverse the length of the second pin recess 35 in a radially inward direction.", "The radially interior terminus of the second pin recess 35 may be formed with a second pin recess enlarged portion 35a.", "Alternatively, the floating stator 30 may be formed with a floating stator annular groove 37 on the concave surface 38 thereof.", "These radial passages, second pin recess 35, second pin recess enlarged portion 35a, and/or floating stator annular groove 37 may serve as a conduit for sealing fluid from the annular recess 26 of the fixed stator 20 to the convex surface 48 of the sealing member 40.Accordingly, the scope of the shaft seal assembly 10 is not limited by the specific combinations of fluid conduits disclosed herein, but extends to all configurations of fluid conduits that may supply a sealing fluid to the sealing member 40.The fixed stator 20 and/or seals 28 between the fixed stator 20 and floating stator 30 may be configured so that the majority of sealing fluid introduced to the inlet 24 passes through the floating stator 30 (by any fluid conduit configuration, as explained above) in a radially inward direction.", "The semi-spherical interface between the floating stator 30 concave surface 38 and the sealing member 40 convex surface 48 may be sealed with seals 28, which seals 28 may be positioned in floating stator seal grooves 30a and/or sealing member seal grooves (not shown).", "The seals 28 may be configured as o-rings, but any suitable structure and/or method may be used without limitation.", "The floating stator 30, sealing member 40, and/or seals 28 therebetween may be configured so that the majority of sealing fluid exiting the floating stator 30 passes through the sealing member 40 through a plurality of radial bores 44 in a direction from the convex surface 48 of the sealing member 40 to the radial interior surface 46 thereof (i.e., in a generally radially inward direction, such that the sealing fluid exits the shaft seal assembly 10 adjacent the shaft 12).", "The fixed stator 20, floating stator 30, and/or sealing member 40 may be configured such that the fluid conduits formed therein allow the majority of sealing fluid to exit the shaft seal assembly 10 from an area between the sealing member 40 and shaft 12 at a predetermined rate for a given set of operation parameters (e.g., sealing fluid viscosity, pressure, and/or volumetric flow rate, rpm of shaft 12, etc.).", "The illustrative embodiment of the shaft seal assembly 10 may be formed with thirty two (32) radial bores 44 in the sealing member 40 in corresponding pairs equally spaced about the circumference of the sealing member, which is best shown in FIGS.", "17A & 17B.", "Each radial bore 44 may be formed with a radial bore inlet 44a adjacent the convex surface 48 and a radial bore outlet 44b adjacent the radial interior surface 46.However, in other embodiments of the sealing member 40 not shown herein, the sealing member 40 may be configured with differently configured radial bores 44, different numbers of radial bores 44, and/or different relative positions of radial bores 44 without limitation.", "It is contemplated that the configuration of radial bores 44 shown in the embodiment of a sealing member 40 pictured in FIGS.", "17A and 17B may be more efficient than other configurations in that a lower volumetric flow rate of sealing fluid may be required for a given set of operational parameters when compared to the prior art.", "Additionally, the smooth, generally cylindrical configuration of the radial interior surface 46 may create a pressurized fluid barrier between the shaft 12 and the sealing member 40 at the interface thereof (e.g., a “lift-off” seal).", "This may lead to a nearly frictionless shaft seal assembly 10 with no and/or minimal contact between the shaft 12 and the sealing member 40 during operation.", "However, in other embodiments, different numbers, spacing, and/or configurations of the fluid conduits in the fixed stator 20, floating stator 30, and/or sealing member 40 may be used without departing from the spirit and scope of the shaft seal assembly 10 as disclosed and claimed herein.", "In light of the present disclosure, it will be apparent to those skilled in the art that the configuration of fluid conduits disclosed herein may be adapted to create a pressurized fluid barrier between any interface at which two elements are rotating with respect to one another, such as the articulated seal disclosed in U.S. Pat.", "No.", "7,090,403.U.S.", "Pat.", "No.", "7,090,403 is incorporated by reference herein in its entirety, and discloses embodiments of a shaft seal assembly having a spherical rotational interface between a rotor and a floating stator (such as those shown in FIGS.", "13, 15, and 15A) and embodiments of a shaft seal assembly having a generally non-rotating spherical interface between two portions of a stator (such as those shown in FIGS.", "14 and 14A).", "Accordingly, the scope of the shaft seal assembly 10 as disclosed herein is not limited by the location and/or type of rotational interface the shaft seal assembly 10 is configured to accommodate.", "For example, in an embodiment not pictured herein, the stator 30 of an embodiment similar to that shown in FIGS.", "13, 15, and 15A may be configured with one or more generally narrow diameter radial bores (which may be generally similar to those shown in the embodiment in FIGS.", "17A and 17B).", "Those radial bores may be configured so as to provide fluid from an external source (which may be in fluid communication with passage 40) to the interface between spherical surfaces on the stator portions 31, 31a (which may be configured as a concave surface on stator 31 and a convex surface on stator 31a).", "Alternatively, the stator 31 may be configured with radial bores that serve to provide fluid from an external source (which may be in fluid communication with passage 40) to the interface between stator 31a and rotor 20, which may be a rotational interface having a labyrinth seal pattern and/or one or more seals (which may be configured as o-rings) therein.", "The specific configuration and/or physical dimensions of the various features of the fixed stator 20, floating stator 30, and/or sealing member 40 (e.g., the radial dimension of the annular recess 26, the surface area of the concave surface 38 and/or convex surface 48, the diameter, length, and orientation of the radial bores 44, etc.)", "may vary depending on the specific application of the shaft seal assembly 10.These variations may be utilized to accommodate different sizes of shafts 12 and/or shaft seal assemblies 10 and different amounts and/or types of relative movement between a shaft 12 and shaft seal assembly 10.The materials used to construct the shaft seal assemblies 10, 25 and various elements thereof will vary depending on the specific application, but it is contemplated that bronze, brass, stainless steel, or other non-sparking metals and/or metallic alloys and/or combinations thereof will be especially useful for some applications.", "Accordingly, the above-referenced elements may be constructed of any material known to those skilled in the art or later developed, which material is appropriate for the specific application of the shaft seal assembly 10, 25, without departing from the spirit and scope of the shaft seal assemblies 10, 25 as disclosed and claimed herein.", "Having described the preferred embodiments, other features of the shaft seal assemblies 10, 25 will undoubtedly occur to those of ordinary skill in the art, as will numerous modifications and alterations in the embodiments as illustrated herein, all of which may be achieved without departing from the spirit and scope of the shaft seal assemblies 10, 25 disclosed herein.", "Accordingly, the methods and embodiments pictured and described herein are for illustrative purposes only.", "It should be noted that the shaft seal assemblies 10, 25 are not limited to the specific embodiments pictured and described herein, but are intended to apply to all similar apparatuses and methods for accommodating shaft(s) misalignment with respect to a housing and/or shaft seal assembly 10, 25, whether the misalignment is angular, radial, and/or axial; and for configuring a shaft seal assembly 10 to create a pressurized fluid barrier between a rotating element and a non-rotating element.", "Modifications and alterations from the described embodiments will occur to those skilled in the art without departure from the spirit and scope of the shaft seal assemblies 10, 25." ] ]
Patent_15872783
[ [ "FUEL COMPOSITION FOR GCI ENGINES AND METHOD OF PRODUCTION", "GCI fuel compositions and methods of making them are described.", "The GCI fuel compositions comprises a fuel blend having an initial boiling point in a range of about 26° C. to about 38° C. and a final boiling point in a range of about 193° C. to less than 250° C., a density of about 0.72 kg/l to about 0.8 kg/l at 15° C., a research octane number of about 70 to about 85, and a cetane number of less than about 27, the fuel blend comprising a naphtha stream and a kerosene stream." ], [ "1.A GCI fuel composition comprising: a fuel blend having an initial boiling point in a range of about 26° C. to about 38° C. and a final boiling point in a range of about 193° C. to less than 250° C., a density of about 0.72 kg/l to about 0.8 kg/l at 15° C., a research octane number of about 70 to about 85, and a cetane number of less than about 27, the fuel blend comprising a naphtha stream and a kerosene stream.", "2.The fuel composition of claim 1 wherein the fuel composition has at least one of: an olefin content of the fuel composition less than about 18 lv %; an aromatic content of the fuel composition less than about 35 lv %; a sulfur content of the fuel composition less than about 10 wt ppm; and a benzene content of the fuel composition less than about 1 lv %.", "3.The fuel composition of claim 1: wherein the naphtha stream comprises at least one of: a hydrotreated straight run naphtha stream; an isomerate stream; a butane stream; a reformate stream; a gasoline stream; a hydrotreated FCC naphtha stream; and an alkylate stream.", "4.A method of making a GCI fuel composition comprising: blending a naphtha stream and a kerosene stream to form a fuel blend having an initial boiling point in a range of about 26° C. to about 38° C. and a final boiling point in a range of about 193° C. to less than 250° C., a density of about 0.72 kg/l to about 0.8 kg/l at 15° C., a research octane number of about 70 to about 85, and a cetane number of less than about 27.5.The method of claim 4 wherein wherein the naphtha stream comprises at least one of: a hydrotreated straight run naphtha stream; an isomerate stream; a butane stream; a reformate stream; a gasoline stream; a hydrotreated FCC naphtha stream; and an alkylate stream.", "6.The method of claim 4 wherein the naphtha stream comprises a hydrotreated straight run naphtha stream and wherein the hydrotreated straight run naphtha stream is formed by: hydrotreating a straight run naphtha stream.", "7.The method of claim 4 wherein the naphtha stream comprises an isomerate stream and wherein the isomerate stream is formed by: isomerizing at least a portion of a hydrotreated straight run naphtha stream.", "8.The method of claim 4 wherein the naphtha stream comprises a reformate stream and wherein the reformate stream is formed by: reforming at least a portion of a hydrotreated straight run naphtha stream.", "9.The method of claim 4 wherein the naphtha stream comprises a gasoline stream and wherein the gasoline stream comprises a blend of one or more of butane, reformate, isomerate, FCC naphtha, and alkylate.", "10.The method of claim 4 wherein the naphtha stream comprises a hydrotreated FCC naphtha stream, and wherein the hydrotreated FCC naphtha stream is formed by: fluid catalytically cracking at least one of an atmospheric gas oil stream, a vacuum gas oil stream, a coker gas oil stream, an unconverted oil stream, a light vacuum gas oil stream, or a hydrotreated gas oil stream to form an FCC stream; separating the FCC stream into the FCC naphtha stream and at least one other stream; and hydrotreating the FCC naphtha stream.", "11.The method of claim 10 wherein separating the FCC stream into the FCC naphtha stream and the at least one other stream comprises: separating the FCC stream into at least the FCC naphtha stream and a FCC cycle oil stream; and hydrotreating and separating the FCC cycle oil stream into at least a hydrotreated kerosene stream, and wherein the kerosene stream comprises the hydrotreated kerosene stream.", "12.The method of claim 4 wherein the naphtha stream comprises an alkylate stream and wherein the alkylate stream is formed by: fluid catalytically cracking at least one of an atmospheric gas oil stream, a vacuum gas oil stream, a coker gas oil stream, an unconverted oil stream, a light vacuum gas oil stream, or a hydrotreated gas oil stream to form an FCC stream; separating the FCC stream into a C3/C4 stream and at least one other stream; separating the C3/C4 stream into at least a C3 olefin stream and a C4 stream; and alkylating at least a portion of the C3 olefin steam, the C4 stream, or both.", "13.The method of claim 4 wherein the kerosene stream is formed by at least one of: separating a hydrocarbon feed stream into a first straight run kerosene stream and at least one other stream, and hydrotreating the first straight run kerosene stream; or separating a hydrocarbon feed stream into a first straight run kerosene/diesel stream and at least one other stream, and hydrotreating and separating the first straight run kerosene/diesel stream into a second straight run kerosene stream, and at least one other stream.", "14.The method of claim 4 wherein the kerosene stream is formed by at least one of: hydrocracking a first atmospheric gas oil stream, and separating the hydrocracked atmospheric gas oil stream into a first kerosene stream and at least one other stream; or hydrocracking a second atmospheric gas oil stream, separating the hydrocracked atmospheric gas oil stream into a kerosene/diesel stream and at least one other stream; and separating the kerosene/diesel stream into a second kerosene stream and at least one other stream.", "15.The method of claim 14 wherein separating the hydrocracked atmospheric gas oil stream into the first kerosene stream and the at least one other stream comprises separating the hydrocracked atmospheric gas oil stream into at least the first kerosene stream, a hydrocracker heavy naphtha stream, and an unconverted oil stream.", "16.The method of claim 14 wherein separating the hydrocracked atmospheric gas oil stream into the kerosene/diesel stream and the at least one other stream comprises separating the hydrocracked atmospheric gas oil stream into at least the kerosene/diesel stream, a hydrocracker heavy naphtha stream, and an unconverted oil stream.", "17.The method of claim 14 wherein the first or second atmospheric gas oil stream is formed by: separating a hydrocarbon feed stream into the first or second atmospheric gas oil stream and at least one other stream.", "18.The method of claim 4 further comprising: separating a hydrocarbon feed stream into at least a straight run naphtha stream, a straight run kerosene/diesel stream, an atmospheric gas oil stream, and an atmospheric residue stream; hydrotreating the straight run naphtha stream to form a hydrotreated straight run naphtha stream; isomerizing the at least a portion of the hydrotreated straight run naphtha stream to form an isomerate stream; reforming at least a portion of the hydrotreated straight run naphtha stream to form a reformate stream; hydrotreating and separating the straight run kerosene/diesel stream into at least a hydrotreated straight run kerosene stream and at least one other stream; hydrocracking at least a portion of the atmospheric gas oil stream to form a hydrocracked stream; separating the hydrocracked stream to form at least a second kerosene/diesel stream, a hydrocracker naphtha stream, and an unconverted oil stream; hydrotreating and separating the second kerosene/diesel stream into a second hydrotreated kerosene stream and at least one other stream; vacuum separating the atmospheric residue stream to form at least a light vacuum gas oil stream and a vacuum gas oil stream; optionally partially hydrocracking at least a portion of one or more of the atmospheric gas oil stream, the light vacuum gas oil, or the unconverted oil stream; fluid catalytically cracking at least one of the atmospheric gas oil stream, the vacuum gas oil stream, a coker gas oil stream, the unconverted oil stream, the light vacuum gas oil stream, or a hydrotreated gas oil stream to form an FCC stream; separating the FCC stream into at least a C3/C4 stream, a FCC naphtha stream, and a FCC cycle oil stream; and hydrotreating the FCC naphtha stream to form a hydrotreated FCC naphtha stream; hydrotreating and separating the FCC cycle oil stream into at least a third hydrotreated kerosene stream; separating the C3/C4 stream into at least a C3 olefin stream and a C4 stream; and alkylating at least a portion of the C3 olefin steam, the C4 stream, or both to form an alkylate stream; wherein the naphtha stream comprises at least one of: the hydrotreated straight run naphtha stream; the isomerate stream; the reformate stream; the hydrotreated FCC naphtha stream; and the alkylate stream; and wherein the kerosene stream comprises at least one of: the straight run hydrotreated kerosene stream; the second hydrotreated kerosene stream; and the third hydrotreated kerosene stream.", "19.The method of claim 18 further comprising at least one of: combining at least a portion of the atmospheric gas oil stream with the light vacuum gas oil stream; and combining the hydrocracker naphtha stream with the hydrotreated straight run naphtha stream.", "20.The method of stream 18 further comprising: coking the vacuum gas oil stream to form a coked vacuum gas oil stream; separating the coked vacuum gas oil stream into at least a coker naphtha stream, a coker gas oil stream, and a coke stream; and at least one of: combining the coker gas oil stream with the light vacuum gas oil stream, or the atmospheric gas oil stream, or both; and combining the coker naphtha stream with the straight run naphtha stream." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Global transport will continue to be powered largely by petroleum-based liquid fuels in the next few decades.", "The increase in demand for transportation fuel will be mostly in the commercial transport sector (heavy duty road, air, marine and rail), and much more diesel and jet fuel will be needed in the future compared to gasoline.", "Moreover, gasoline octane quality needs to increase to enable more efficient spark ignition engines.", "This poses significant challenges to the refining industry and is likely to increase the availability of low octane components in the gasoline boiling range.", "One approach to mitigate the imbalance in demand growth between gasoline and middle distillates is to change the demand requirements of future engines.", "There is little prospect of moving aviation from using conventional jet fuel to any significant degree, but some compression ignition (CI) engines could move from conventional diesel to natural gas (NG), particularly in markets such as the U.S. where the shale gas revolution has brought in an era of cheap and abundant gas.", "Development trends in internal combustion (IC) engines are likely to have a significant impact on the properties required of future fuels.", "Moreover, there are very good opportunities to develop new engine/fuel systems which can be beneficial from the fuel and engine side as well as help to mitigate the demand imbalance.", "For instance, CI engines running on low octane (research octane number (RON) of about 70) gasoline and with more relaxed volatility requirements compared to current gasoline could be at least as efficient as current diesel engines but cheaper.", "This concept is known as Gasoline Compression Ignition (GCI).", "Today's IC engines are either spark ignition (SI) engines running on gasoline or CI engines running on diesel fuel.", "In SI engines, gasoline is premixed with air, and the mixture is compressed.", "Heat release occurs in an expanding turbulent flame initiated by a spark near the top of the compression stroke, top dead center (TDC).", "In a diesel engine, air is compressed, and fuel is injected near TDC.", "Combustion is initiated by autoignition as the fuel vaporizes, mixes, and reacts with oxygen in the engine cylinder.", "Currently, the passenger car sector is dominated by SI engines, whereas the commercial sector (heavy duty road, air, rail and marine) is dominated by CI engines.", "SI engines are run at a stoichiometric fuel and air mixture that enables a three-way catalyst to be used to treat the exhaust and reduce tail-pipe emissions of unburned hydrocarbons (HC), carbon monoxide (CO) and NOx to extremely low levels.", "CI engines are more efficient than SI engines, but suffer from high engine-out emissions of particulates and NOx (nitrogen oxides) which are very difficult to control by after-treatment of the oxygen-rich exhaust with catalysts.", "Particulates are formed in diesel engines because diesel fuel with a Cetane Number (CN) greater than about 40 autoignites too easily, before it has had a chance to mix adequately with oxygen.", "Exhaust gas recirculation (EGR) can be used to control NOx, but it reduces in-cylinder particulate oxidation and leads to increased engine-out particulate emissions.", "Hence, it is very difficult to control particulates and NOx simultaneously in diesel engines.", "Engine manufacturers are currently trying to solve this problem by using very expensive technology such as very high injection pressures and complex after-treatment systems to control NOx and particulates.", "Some of these technologies compromise fuel efficiency.", "Controlling particulates and nitrogen oxides (NOx) at reasonable cost without compromising efficiency would be much easier to meet if diesel engines were run on fuels which do not ignite as easily as diesel fuel, allowing more time for fuel and air to mix before combustion starts.", "Gasoline Compression Ignition (GCI) engines are currently under development that can achieve substantially higher combustion efficiency than conventional diesel and gasoline spark ignition engines.", "These new GCI engines are similar in operation to Homogeneous Charge Compression Ignition (HCCI) engines, but have the fuel injection just prior to TDC on the compression stroke.", "These new engines can utilize different fuel compositions than conventional internal combustion engines.", "GCI engines may be at least as efficient as CI engines, and more efficient than the most advanced SI engines.", "They may also be less expensive than advanced CI engines.", "There is a need for a fuel which has acceptable particulate and NOx emissions and which can be used in GCI engines, and for methods of making the fuel." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>One aspect of the invention is a GCI fuel composition.", "In one embodiment, the GCI fuel composition comprises a fuel blend having an initial boiling point in a range of about 26° C. to about 38° C. and a final boiling point in a range of about 193° C. to less than 250° C., a density of about 0.72 kg/l to about 0.8 kg/l at 15° C., a research octane number of about 70 to about 85, and a cetane number of less than about 27, the fuel blend comprising a naphtha stream and a kerosene stream.", "Another aspect of the invention is method of making a GCI fuel composition.", "In one embodiment, the method includes blending a naphtha stream and a kerosene stream to form a fuel blend having an initial boiling point in a range of about 26° C. to about 38° C. and a final boiling point in a range of about 193° C. to less than 250° C., a density of about 0.72 kg/l to about 0.8 kg/l at 15° C., a research octane number of about 70 to about 85, and a cetane number of less than about 27." ], [ "This application is a continuation of co-pending International Application No.", "PCT/US16/41755, entitled FUEL COMPOSITION FOR GCI ENGINES AND METHOD OF PRODUCTION, filed Jul.", "11, 2016, which claims the benefit of U.S.", "Provisional Application Ser.", "No.", "62/194,631, entitled FUEL COMPOSITION AND METHOD OF MAKING, filed Jul.", "20, 2015, each of which is incorporated herein by reference.", "BACKGROUND OF THE INVENTION Global transport will continue to be powered largely by petroleum-based liquid fuels in the next few decades.", "The increase in demand for transportation fuel will be mostly in the commercial transport sector (heavy duty road, air, marine and rail), and much more diesel and jet fuel will be needed in the future compared to gasoline.", "Moreover, gasoline octane quality needs to increase to enable more efficient spark ignition engines.", "This poses significant challenges to the refining industry and is likely to increase the availability of low octane components in the gasoline boiling range.", "One approach to mitigate the imbalance in demand growth between gasoline and middle distillates is to change the demand requirements of future engines.", "There is little prospect of moving aviation from using conventional jet fuel to any significant degree, but some compression ignition (CI) engines could move from conventional diesel to natural gas (NG), particularly in markets such as the U.S. where the shale gas revolution has brought in an era of cheap and abundant gas.", "Development trends in internal combustion (IC) engines are likely to have a significant impact on the properties required of future fuels.", "Moreover, there are very good opportunities to develop new engine/fuel systems which can be beneficial from the fuel and engine side as well as help to mitigate the demand imbalance.", "For instance, CI engines running on low octane (research octane number (RON) of about 70) gasoline and with more relaxed volatility requirements compared to current gasoline could be at least as efficient as current diesel engines but cheaper.", "This concept is known as Gasoline Compression Ignition (GCI).", "Today's IC engines are either spark ignition (SI) engines running on gasoline or CI engines running on diesel fuel.", "In SI engines, gasoline is premixed with air, and the mixture is compressed.", "Heat release occurs in an expanding turbulent flame initiated by a spark near the top of the compression stroke, top dead center (TDC).", "In a diesel engine, air is compressed, and fuel is injected near TDC.", "Combustion is initiated by autoignition as the fuel vaporizes, mixes, and reacts with oxygen in the engine cylinder.", "Currently, the passenger car sector is dominated by SI engines, whereas the commercial sector (heavy duty road, air, rail and marine) is dominated by CI engines.", "SI engines are run at a stoichiometric fuel and air mixture that enables a three-way catalyst to be used to treat the exhaust and reduce tail-pipe emissions of unburned hydrocarbons (HC), carbon monoxide (CO) and NOx to extremely low levels.", "CI engines are more efficient than SI engines, but suffer from high engine-out emissions of particulates and NOx (nitrogen oxides) which are very difficult to control by after-treatment of the oxygen-rich exhaust with catalysts.", "Particulates are formed in diesel engines because diesel fuel with a Cetane Number (CN) greater than about 40 autoignites too easily, before it has had a chance to mix adequately with oxygen.", "Exhaust gas recirculation (EGR) can be used to control NOx, but it reduces in-cylinder particulate oxidation and leads to increased engine-out particulate emissions.", "Hence, it is very difficult to control particulates and NOx simultaneously in diesel engines.", "Engine manufacturers are currently trying to solve this problem by using very expensive technology such as very high injection pressures and complex after-treatment systems to control NOx and particulates.", "Some of these technologies compromise fuel efficiency.", "Controlling particulates and nitrogen oxides (NOx) at reasonable cost without compromising efficiency would be much easier to meet if diesel engines were run on fuels which do not ignite as easily as diesel fuel, allowing more time for fuel and air to mix before combustion starts.", "Gasoline Compression Ignition (GCI) engines are currently under development that can achieve substantially higher combustion efficiency than conventional diesel and gasoline spark ignition engines.", "These new GCI engines are similar in operation to Homogeneous Charge Compression Ignition (HCCI) engines, but have the fuel injection just prior to TDC on the compression stroke.", "These new engines can utilize different fuel compositions than conventional internal combustion engines.", "GCI engines may be at least as efficient as CI engines, and more efficient than the most advanced SI engines.", "They may also be less expensive than advanced CI engines.", "There is a need for a fuel which has acceptable particulate and NOx emissions and which can be used in GCI engines, and for methods of making the fuel.", "SUMMARY OF THE INVENTION One aspect of the invention is a GCI fuel composition.", "In one embodiment, the GCI fuel composition comprises a fuel blend having an initial boiling point in a range of about 26° C. to about 38° C. and a final boiling point in a range of about 193° C. to less than 250° C., a density of about 0.72 kg/l to about 0.8 kg/l at 15° C., a research octane number of about 70 to about 85, and a cetane number of less than about 27, the fuel blend comprising a naphtha stream and a kerosene stream.", "Another aspect of the invention is method of making a GCI fuel composition.", "In one embodiment, the method includes blending a naphtha stream and a kerosene stream to form a fuel blend having an initial boiling point in a range of about 26° C. to about 38° C. and a final boiling point in a range of about 193° C. to less than 250° C., a density of about 0.72 kg/l to about 0.8 kg/l at 15° C., a research octane number of about 70 to about 85, and a cetane number of less than about 27.BRIEF DESCRIPTION OF THE DRAWING The FIGURE is an illustration of one embodiment of a refining process according the present invention.", "DETAILED DESCRIPTION OF THE INVENTION A new low octane fuel composition has been identified for use in GCI engines, as well as a refinery process to produce the new fuel composition.", "The GCI fuel composition has a wide boiling range from light naphtha to kerosene, a low RON, and a low CN, while meeting all other gasoline specifications for olefins, aromatics, and sulfur.", "The GCI fuel composition is injected earlier in the engine cycle compared to normal diesel fuel.", "Particulates and NOx can be far more easily controlled by using fuels with high ignition delay.", "The final boiling point (FBP) of the GCI fuel composition is higher than that of conventional gasoline, which provides more time for the fuel to mix with oxygen before combustion starts so that particulate formation can be minimized.", "This makes it easier to control NOx using EGR.", "Also, the injection pressure does not need to be as high as it is for CI engines (e.g., about 40-50 MPa); rather, it can be closer to the pressure of turbo-charged SI engines (e.g., about 15 MPa).", "Consequently, the after-treatment focus can be on the oxidation of hydrocarbons (HC) and CO rather than control of NOx and particulates.", "The efficiency if the GCI engine is at least as high as with conventional diesel combustion.", "The GCI fuel composition comprises a fuel blend having an initial boiling point in a range of about 26° C. to about 38° C. and a final boiling point of about 193° C. to less than 250° C., a density of about 0.72 kg/l to about 0.8 kg/l at 15° C., a RON of about 70 to about 85, and a CN of less than about 27.Desirably, the olefin content is less than about 18 lv % (liquid volume %), and the aromatic content is less than about 35 lv %.", "Desirably, the fuel composition has a sulfur content of less than about 50 wt ppm, or less than about 10 wt ppm, and a benzene content of less than about 1 lv %.", "The cetane number is generally at least about 5 or at least about 10.The GCI fuel composition can be made by blending a naphtha stream and a kerosene stream to have a fuel blend having the specified properties.", "The final boiling point can be in a range of about 193° C. to less than 250° C., or about 193° C. to less than 245° C., or about 193° C. to less than 240° C., or about 193° C. to less than 235° C., or about 193° C. to less than 230° C., or about 193° C. to less than 225° C., or about 193° C. to less than 220° C., or about 193° C. to less than 215° C. A unique specification of the new GCI fuel composition is the end point limitation of less than 250° C., coupled with a cetane number less than 27.Directionally, as the hydrocarbon chain length increases (higher end point), the autoignition temperature for a hydrocarbon/air mixture decreases, autoigniting quicker.", "NOx and particulates are formed when fuel autoignites before mixing adequately with oxygen.", "The lower end point of new GCI fuel composition, less than 250° C., limits the amount of diesel (longer hydrocarbon chain) into the new GCI fuel composition.", "Jet and kerosene streams have lower cetane values than diesel; i.e., about 40 vs. higher cetane numbers for diesel.", "(The EU-V diesel specification for cetane number is at least 51).", "The higher the cetane number, the easier it is for the fuel to autoignite.", "Consequently, the end point limitation will limit the hydrocarbon chain length, minimizing the formation of NOx and particulates due to limiting autoignition, resulting in a cleaner fuel with reduced emissions.", "The new GCI fuel composition can be produced in a conventional refinery with modifications.", "One unique characteristic of the process is that, in some embodiments, the heavy naphtha can bypass the reforming unit and be blended with light naphtha and a kerosene fraction that only needs to be hydrotreated to reduce sulfur content.", "This reduces the refinery operating cost to produce the fuel and increases the produced fuel volume by avoiding volume loss across the reforming unit.", "The naphtha stream can comprise one or more of a hydrotreated straight run naphtha stream; an isomerate stream; a butane stream; a reformate stream; a gasoline stream; a hydrotreated FCC naphtha stream; and an alkylate stream.", "The kerosene stream can be hydrotreated straight run kerosene or hydrotreated kerosene made from FCC cycle oil.", "The kerosene stream can include jet fuel, either straight run jet fuel or jet fuel made from FCC cycle oil.", "One advantage of the new GCI fuel composition is that lower value streams, such as nC4 (RONC about 94), light naphtha (C5-C6, RONC about 65), and isomerate (C5/C6, RONC about 80-90), can be used in the composition.", "This allows other high RONC gasoline blending streams, e.g., 2-methylpropane (iC4, RONC about 105), reformate (RONC about 90-104), alkylate (RONC about 94-96), and/or methyl-tert-butyl ether (MTBE, RONC about 117) to be used for the higher RONC gasoline blends.", "Isomerate is a gasoline blend stock, but the amount allowed in gasoline is limited due to distillation and Reed vapor pressure (RVP) constraints to a maximum of about 50 lv %.", "However, the new GCI fuel composition allows for higher amounts, e.g., up to about 80 lv %.", "MTBE and alkylate are very valuable blend stocks for gasoline.", "They are not required for the GCI fuel composition, although they can be used if desired.", "The amount of MTBE being produced in a refinery is typically limited by the amount of iC4 olefins from the FCC (Fluid Catalytic Cracking) and Coker units.", "The MTBE produced is typically consumed by the refiner for the higher gasoline blends.", "Alkylate is also another key blend stock which will not be required for the GCI fuel composition.", "Alkylate is a desired blend stock due to its properties: no aromatics, no benzene, and low RVP with high RONC.", "As gasoline trends toward higher RONC, alkylate and MTBE will be required for the higher RONC blends, making them more valuable blend stocks.", "This reduces the desirability of using them in the GCI fuel composition.", "One limiting specification for the GCI fuel composition is the specific gravity.", "However, since the upper limit of the final boiling point can be higher than for gasoline, kerosene can be blended to increase the specific gravity and energy content.", "Thus, the GCI fuel composition provides the refiner significant product blending flexibility and a value added disposition for low value streams.", "The naphtha stream has an initial boiling point range of about 0° C. to about 104° C. and a final boiling point range of about 146° C. to about 226° C. In some embodiments, the naphtha stream contains hydrotreated straight run naphtha, including light naphtha and/or heavy naphtha, having an initial boiling point range of about 0° C. to about 104° C. and a final boiling point range of about 146° C. to about 204° C. The hydrotreated straight run naphtha stream typically has a sulfur content of less than about 50 wt ppm, or less than about 10 wt ppm.", "The hydrotreated straight run light naphtha stream typically has an initial boiling point range of about 0° C. to about 35° C. and a final boiling point range of about 74° C. to about 104° C. The hydrotreated straight run heavy naphtha stream typically has an initial boiling point range of about 74° C. to about 104° C. and a final boiling point range of about 146° C. to about 204° C. The isomerate stream typically has an initial boiling point range of about 27° C. to about 32° C. and a final boiling point range of about 79° C. about 107° C. The butane stream typically has an initial boiling point of about −12° C. and a final boiling point of about −1° C. The reformate stream typically has an initial boiling point range of about 27° C. to about 32° C. and a final boiling point range of about 182° C. to about 222° C. The gasoline stream typically has an initial boiling point range of about 32° C. to about 49° C. and a final boiling point range of about 182° C. to about 216° C. The hydrotreated FCC naphtha stream typically has an initial boiling point range of about 32° C. to about 49° C. and a final boiling point range of about 82° C. to about 216° C. The hydrotreated FCC naphtha stream typically has a sulfur content of less than about 50 wt ppm, or less than about 10 wt ppm.", "The alkylate stream typically has an initial boiling point range of about 32° C. to about 49° C. and a final boiling point range of about 171° C. to about 188° C. The kerosene stream typically has an initial boiling point range of about 146° C. to about 166° C. and a final boiling point range of about 249° C. to about 271° C. In some embodiments, the kerosene stream can include jet fuel.", "The hydrotreated kerosene stream typically has a sulfur content of less than about 50 wt ppm, or less than about 10 wt ppm.", "The jet fuel stream typically has an initial boiling point range of about 149° C. to about 166° C. and a final boiling point range of about 243° C. to about 252° C. The hydrotreated jet fuel stream typically has a sulfur content of less than about 50 wt ppm, or less than about 10 wt ppm.", "The hydrotreated straight run naphtha stream is typically present in an amount of about 0 to about 30 lv %, or about 0 lv % to about 25 lv %, or about 0 lv % to about 20 lv %, or about 5 lv % to about 30 lv %, or about 10 lv % to about 30 lv %.", "The isomerate stream is typically present in an amount of about 0 lv % to about 80 lv %, or about 0 lv % to about 75 lv %, or about 0 lv % to about 70 lv %, or about 0 lv % to about 65 lv %, or about 5 lv % to about 80 lv %, or about 10 lv % to about 80 lv %, or about 20 lv % to about 80 lv %, or about 30 lv % to about 80 lv %, or about 40 lv % to about 80 lv %, or about 50 lv % to about 80 lv % or about 5 lv % to about 65 lv %, or about 10 lv % to about 65 lv %, or about 20 lv % to about 65 lv %, or about 30 lv % to about 65 lv %, or about 40 lv % to about 65 lv %, or about 50 lv % to about 65 lv %.", "The butane stream is typically present in an amount of about 0 lv % to about 10 lv %.", "The reformate stream is typically present in an amount of about 0 lv % to about 50 lv %, or about 0 lv % to about 40 lv %, or about 0 lv % to about 30 lv %, or about 0 lv % to about 20 lv %, about 0 lv % to about 15 lv %.", "The gasoline stream is typically present in an amount of about 0 lv % to about 50 lv %, or about 0 lv % to about 40 lv %, or about 0 lv % to about 30 lv %, or about 0 lv % to about 20 lv %, or about 0 lv % to about 10 lv %, or about 10 lv % to about 50 lv %, or about 20 lv % to about 50 lv %, or about 30 lv % to about 50 lv %, or about 40 lv % to about 50 lv %.", "The hydrotreated FCC naphtha stream is typically present in an amount of about 0 lv % to about 40 lv %, or about 0 lv % to about 35 lv %, or about 0 lv % to about 30 lv %, or about 0 lv % to about 25 lv %, or about 0 lv % to about 20 lv %.", "The alkylate stream is typically present in an amount of about 0 lv % to about 35 lv %, or about 0 lv % to about 30 lv %, or about 0 lv % to about 25 lv %.", "The kerosene stream (straight run and/or made by hydrocracking) is typically present in an amount of about 0 lv % to about 50 lv %, or about 0 lv % to about 45 lv %, or about 0 lv % to about 40 lv %, or about 0 lv % to about 35 lv %, or about 0 lv % to about 30 lv %, or about 0 lv % to about 25 lv %, or about 5 lv % to about 50 lv %, or about 10 lv % to about 50 lv %, or about 15 lv % to about 50 lv %, or about 20 lv % to about 50 lv %.", "The jet fuel stream (straight run and/or made by hydrocracking) is typically present in an amount of about 0 lv % to about 40 lv %, or about 0 lv % to about 35 lv %, or about 0 lv % to about 30 lv %, or about 0 lv % to about 25 lv %.", "The hydrotreated kerosene and/or jet fuel streams typically have a sulfur content of less than about 50 wt ppm, or less than about 10 wt ppm.", "In some embodiments, the GCI fuel composition includes about 0 lv % to about 20 lv % hydrotreated heavy naphtha, about 50 lv % to about 70 lv % isomerate, about 0 lv % to about 10 lv % butanes, about 0 lv % to about 15 lv % reformate, about 0 lv % to about 20 lv % hydrotreated FCC naphtha, and about 0 lv % to about 35 lv % hydrotreated kerosene.", "Shown below are only a few non-limiting examples of possible blends for the GCI fuel composition.", "The blends highlight the flexibility and the large ranges possible.", "The GCI fuel composition increases the refiners blending flexibility and profitability by using the lower value streams.", "Blend Blend stock liq vol A B C Kerosene lv % 29.0% 26.7% 0.1% Hydrotreated FCC Naphtha lv % 0.1% 14.7% 17.2% Hydrotreated Straight Run lv % 0.0% 0.0% 17.2% Heavy Naphtha Isomerate lv % 63.8% 57.3% 53.2% nC4 lv % 7.0% 1.3% 0.4% Reformate lv % 0.0% 0.0% 11.8% Total lv % 100.0% 100.0% 100.0% In some embodiments, the hydrotreated straight run heavy naphtha stream is formed by hydrotreating a straight run naphtha stream to form a hydrotreated straight run naphtha stream.", "In some embodiments, the hydrotreated straight run naphtha stream can be separated into a hydrotreated straight run light naphtha stream and a hydrotreated straight run heavy naphtha stream.", "The hydrotreated straight run light and heavy naphtha streams typically have a sulfur content of less than about 50 wt ppm, or less than about 10 wt ppm.", "In some embodiments, the isomerate stream can be formed by isomerizing at least a portion of the hydrotreated straight run naphtha, e.g., the hydrotreated straight run light naphtha stream.", "In some embodiments, the butanes stream can be formed by fractionating and treating (e.g., with an amine treatment) a hydrocarbon feed stream.", "Alternatively, the butanes stream can be formed as byproducts of various processes in the refinery, including, but not limited to, reforming, fluid catalytic cracking, coking, and hydrocracking.", "One or more of the byproduct streams from these processes can be combined, treated (e.g., with an amine treatment), and fractionated to form the butane stream.", "In some embodiments, the reformate stream can be formed by reforming at least a portion of the hydrotreated straight run naphtha stream, e.g., the hydrotreated straight run heavy naphtha stream.", "In some embodiments, the gasoline stream is formed by blending one or more of butanes, reformate, isomerate, FCC naphtha, and alkylate.", "The gasoline stream would meet the product specification for gasoline, e.g., the specifications for olefins, sulfur (e.g., less than about 50 wt ppm, or less than about 10 wt ppm), and aromatics.", "In some embodiments, the hydrotreated FCC naphtha stream can be formed by fluid catalytically cracking at least one of an atmospheric gas oil stream, a vacuum gas oil stream, a coker gas oil stream, an unconverted oil stream, a light vacuum gas oil stream, or a hydrotreated gas oil stream to form an FCC stream.", "The FCC stream can be separated into a FCC naphtha stream (typically along with one or more other streams), which can then be hydrotreated.", "In some embodiments, the other streams can include a FCC cycle oil stream.", "In some embodiments, the FCC cycle oil stream can be hydrotreated and separated into a kerosene stream (including jet fuel or the jet fuel can be a separate stream, as desired) (typically along with one or more other streams).", "In some embodiments, the alkylate stream can be formed by fluid catalytically cracking at least one of an atmospheric gas oil stream, a vacuum gas oil stream, a coker gas oil stream, an atmospheric gas oil stream, a heavy cycle oil stream, a light vacuum gas oil stream, or a hydrotreated gas oil stream to form an FCC stream.", "The FCC stream can be separated into a C3/C4 stream (typically along with one or more other streams).", "The C3/C4 stream includes C3 and C4 paraffins and olefins.", "In some embodiments, the C3/C4 stream can be separated into at least a C3 olefin stream and a C4 stream.", "Further separation can take place, if desired, such as separating the C4 stream into a C4 olefin stream and a C4 paraffin stream, and/or separating the iC4 olefins from the C4 stream or the C4 olefin stream.", "The C3 olefins and/or all or a portion of the C4 stream can be alkylated.", "All or a portion of the iC4 olefin stream can be converted to methyl-tert-butyl ether (MTBE).", "Alternatively, a C4 stream could be formed by separating a hydrocarbon feed stream into different fractions including a C4 olefin stream and/or an iC4 olefin stream.", "In some embodiments, the kerosene stream can be formed by separating a hydrocarbon feed stream into a straight run kerosene stream (typically along with one or more other streams) and hydrotreating the straight run kerosene stream, or by separating a hydrocarbon feed stream into a straight run kerosene/diesel stream (typically along with one or more other streams), and hydrotreating and separating the straight run kerosene/diesel stream into a hydrotrotreated straight run kerosene stream (including jet fuel or the jet fuel can be a separate stream, as desired) (typically along with one or more other streams).", "The hydrotreated kerosene stream typically has a sulfur content of less than about 50 wt ppm, or less than about 10 wt ppm.", "In some embodiments, the kerosene stream can be formed by at least one of: hydrocracking a first atmospheric gas oil stream, and separating the hydrocracked atmospheric gas oil stream into a first kerosene stream and at least one other stream; or hydrocracking a second atmospheric gas oil stream, separating the hydrocracked atmospheric gas oil stream into a kerosene/diesel stream and at least one other stream; and separating the kerosene/diesel stream into a second kerosene stream and at least one other stream.", "In some embodiments, the first and/or second kerosene streams can be optionally hydrotreated if desired.", "The hydrotreated kerosene stream typically has a sulfur content of less than about 50 wt ppm, or less than about 10 wt ppm.", "In some embodiments, a jet fuel stream can be formed by separating a hydrocarbon feed into a straight run jet fuel stream (typically along with one or more other streams), and hydrotreating the straight run jet fuel stream; separating a hydrocarbon feed into a straight run jet/diesel stream (typically along with one or more other streams), and hydrotreating and separating the straight run jet/diesel stream into a hydrotreated jet fuel stream (typically along with one or more other streams); hydrocracking an atmospheric gas oil stream, and separating the hydrocracked atmospheric gas oil stream into a jet fuel stream (typically along with one or more other streams), or by hydrocracking an atmospheric gas oil stream, and separating the hydrocracked atmospheric gas oil stream into a kerosene/diesel stream (typically along with one or more other streams), and separating the kerosene/diesel stream into a jet fuel stream, (typically along with one or more other streams).", "In some embodiments, the jet fuel streams made by hydrocracking the atmospheric gas oil stream can be optionally hydrotreated if desired.", "The hydrotreated jet fuel stream(s) typically has a sulfur content of less than about 50 wt ppm, or less than about 10 wt ppm.", "In some embodiments, as discussed above, rather than forming separate jet fuel and kerosene streams, a single stream containing kerosene and jet fuel can be formed.", "In some embodiments, the hydrocracked atmospheric gas oil stream is separated into at least the jet fuel stream or the kerosene/diesel stream, a hydrocracker heavy naphtha stream, and an unconverted oil stream.", "In some embodiments, the hydrocracker heavy naphtha stream can be combined with the straight run naphtha stream.", "In some embodiments, the atmospheric gas oil stream can be formed by separating a hydrocarbon feed stream into the atmospheric gas oil stream (typically along with one or more other streams).", "In some embodiments, a hydrocarbon feed stream is separated into at least a straight run naphtha stream, a straight run kerosene/diesel stream, an atmospheric gas oil stream, and an atmospheric residue stream.", "The straight run naphtha stream can be hydrotreated to form a hydrotreated straight run naphtha stream.", "At least a portion of the hydrotreated straight run naphtha stream can be isomerized to form an isomerate stream.", "At least a portion of the hydrotreated straight run naphtha stream can be reformed to form the reformate stream.", "The straight run kerosene/diesel stream can be hydrotreated and separated into at least a hydrotreated straight run kerosene stream and at least one other stream.", "At least a portion of the atmospheric gas oil stream can be hydrocracked to form a hydrocracked stream.", "The hydrocracked stream can be separated to form at least a second kerosene/diesel stream, a hydrocracker naphtha stream, and an unconverted oil stream.", "The kerosene/diesel stream can be separated (and optionally hydrotreated) into at least a second kerosene stream and at least one other stream.", "The atmospheric residue stream can be vacuum separated to form a light vacuum gas oil stream and a vacuum gas oil stream.", "Optionally, at least a portion of one or more of the atmospheric gas oil stream, the light vacuum gas oil, or the unconverted oil stream can be partially hydrocracked.", "At least one of the atmospheric gas oil stream, the vacuum gas oil stream, a coker gas oil stream, the unconverted oil stream, the light vacuum gas oil stream, or a hydrotreated gas oil stream can be fluid catalytically cracked to form an FCC stream.", "The FCC stream can be separated into at least a C3/C4 stream, an FCC naphtha stream, and an FCC cycle oil stream (including light and/or heavy cycle oil).", "The FCC naphtha stream can be hydrotreated to form a hydrotreated FCC naphtha stream.", "The FCC cycle oil stream can be hydrotreated and separated into at least a third hydrotreated kerosene stream.", "The C3/C4 stream can be separated into at least a C3 olefin stream and a C4 stream.", "At least a portion of the C3 olefin steam, the C4 stream, or both can be alkylated to form an alkylate stream.", "The naphtha stream comprises at least one of: the straight run hydrotreated naphtha stream; the isomerate stream; the reformate stream; the hydrotreated FCC naphtha stream; the alkylate stream, a butane stream, and a gasoline stream.", "The straight run hydrotreated naphtha stream and the hydrotreated FCC naphtha stream typically have a sulfur content of less than about 50 wt ppm, or less than about 10 wt ppm.", "The kerosene stream comprises at least one of: the straight run hydrotreated kerosene stream; the second kerosene stream; and the third hydrotreated kerosene stream.", "The straight run hydrotreated kerosene stream and the third hydrotreated kerosene streams typically have a sulfur content of less than about 50 wt ppm, or less than about 10 wt ppm.", "In some embodiments, the method can include at least one of: combining at least a portion of the atmospheric gas oil stream with the light vacuum gas oil stream; and combining the hydrocracker naphtha stream with the hydrotreated straight run naphtha stream.", "In some embodiments, the vacuum gas oil stream can be coked to form a coked vacuum gas oil stream.", "The coked vacuum gas oil stream can be separated into at least a coker naphtha stream, a coker gas oil stream, and a coke stream.", "The method can include at least one of: combining the coker gas oil stream with the light vacuum gas oil stream, or the atmospheric gas oil stream, or both; and combining the coker naphtha stream with the straight run naphtha stream.", "The FIGURE illustrates one embodiment of a process 100 for making the GCI fuel composition.", "A hydrocarbon feed stream 105 is fed to a crude distillation unit 110 where it is separated into multiple streams including e.g., liquefied petroleum gas (LPG) stream 115, straight run naphtha stream 120, straight run kerosene/diesel stream 125, atmospheric gas oil stream 130, and atmospheric residue stream 135.The LPG stream 115 can be recovered and be sold or used as feed for a hydrogen plant, for example.", "The straight run naphtha stream 120 can be sent to naphtha hydrotreating zone 140 where it is hydrotreated in the presence of hydrogen over a hydrotreating catalyst to remove heteroatoms, such as sulfur, nitrogen, and metals from the hydrocarbon feedstock, and to saturate hydrocarbons with double and triple bonds and aromatics.", "In some embodiments, the hydrotreated straight run naphtha may be separated into a hydrotreated straight run light naphtha stream 145 and a hydrotreated straight run heavy naphtha stream 150.The hydrotreated straight run light naphtha stream 145 can be sent to isomerization zone 155 where the hydrotreated straight run light naphtha is isomerized over an isomerization catalyst to increase alkyl branching on the naphtha molecules.", "The isomerate stream 160 can be sent to a gasoline pool 162 for blending.", "At least a portion 165 of the isomerate stream 160 can be sent to the blending zone 170 for the GCI fuel composition.", "At least a portion 175 of the hydrotreated straight run heavy naphtha stream 150 can bypass the catalytic reforming zone 180 and be sent to the blending zone 170.At least a portion 185 of the hydrotreated straight run heavy naphtha stream 150 can be sent to the catalytic reforming zone 180 for reforming over reforming catalyst to increase the alkyl branching and aromaticization of the naphtha molecules.", "The reformate stream 190 can be sent to the gasoline pool 162.A portion 195 of the reformate stream 190 can be sent to the blending zone 170.The straight run kerosene/diesel stream 125 can be hydrotreated over hydrotreating catalyst in the presence of hydrogen and separated in a hydrotreating and separation zone 196 into at least kerosene stream 197 and diesel stream 198, and optionally straight run jet fuel stream 199.Kerosene stream 197 and/or optional jet fuel stream 199 can be sent to the blending zone 170.Diesel stream 198 can be sent to the diesel pool (not shown).", "Alternatively, separate straight run kerosene, jet fuel, and diesel streams could be formed in the crude distillation unit 110.The atmospheric gas oil stream 130 can be sent to a hydrocracking zone 200 for hydrocracking the atmospheric gas oil stream over a hydrocracking catalyst in the presence of hydrogen.", "The hydrocracked atmospheric gas oil is then separated into multiple streams including, e.g., a hydrocracker naphtha stream 205, a kerosene/diesel stream 210, and an unconverted oil stream 215.The hydrocracker naphtha stream 205 can be combined with hydrotreated straight run heavy naphtha stream 150, if desired.", "The kerosene/diesel stream 210 can be separated into jet fuel stream 220, kerosene stream 222, and diesel stream 225 in separation zone 217.Separation zone 217 can include optionally hydrotreating the jet fuel stream 220, kerosene stream 222, and diesel stream 225 in the presence of hydrogen over a hydrotreating catalyst, if desired.", "Jet fuel stream 220 and/or kerosene stream 222 can be sent to the blending zone 170, while diesel stream 225 can be sent to the diesel pool.", "Alternatively, the kerosene stream and jet fuel streams can be combined.", "The atmospheric residue stream 135 can be sent to a vacuum separation zone 230 where it is separated into light vacuum gas oil stream 235 and vacuum gas oil stream 240.Light vacuum gas oil stream 235 is sent to partial hydrocracking zone 245 for partial hydrocracking over hydrocracking catalyst in the presence of hydrogen.", "The hydrocracked stream 250 is sent to a fluid catalytic cracking (FCC) zone 255.The FCC stream is separated into a C3/C4 stream 260, FCC naphtha stream 265, FCC cycle oil stream 270, and slurry oil stream 275.The C3/C4 stream 260 can be separated into two or more streams, such as a C3 olefin stream and a C4 stream.", "The C3 olefins and/or a portion of the C4 stream can be sent to an alkylation zone 285 for alkylation.", "The alkylate stream 290 can be sent to the gasoline pool 162.A portion 293 of the alkylate stream 290 can be sent to the blending zone 170.An iC4 olefin portion 295 of stream 260 can be sent to an etherification zone 300 where it is reacted to form an MTBE stream 305.The MTBE stream 305 can be sent to the gasoline pool 162.The FCC naphtha stream 265 can be sent to hydrotreating zone 280 where it is hydrotreated over hydrotreating catalyst in the presence of hydrogen.", "The hydrotreated FCC naphtha stream 307 can be sent to the gasoline pool 162.A portion 310 of the hydrotreated FCC naphtha stream 307 can be sent to the blending zone 170.In some embodiments, a butane stream 311 can be sent to the blending zone 170.In some embodiments, a gasoline stream 313 from the gasoline pool 162 can be sent to the blending zone 170.In some embodiments, the FCC cycle oil stream 270 can be sent to hydrotreating and separation zone 196 to be hydrotreated and separated into hydrotreated kerosene stream 197, hydrotreated diesel stream 198, and hydrotreated jet fuel stream 199.Alternatively, the kerosene and jet fuel streams can be combined.", "The slurry oil stream 275 can be used as fuel oil.", "In some embodiments, the vacuum gas oil stream 240 can be sent to a coking zone 315 for coking.", "It can be separated into a coker naphtha stream 320, a coker gas oil stream 325, and a coke stream 330.The coker naphtha stream 320 can be sent to the naphtha hydrotreating zone 140.In some embodiments, the coker gas oil stream 325 can be combined with light vacuum gas oil stream 235 and/or atmospheric gas oil stream 130.The coke stream 330 can be used for fuel in the refineries utilities.", "Depending on the metal content, it could also be sold for use as fuel for industrial boilers, for use in cement, and for use in synthetic graphite.", "In some embodiments, a portion 335 of the atmospheric gas oil stream 130 can be sent to the fluid catalytic cracking zone 255.In some embodiments, a portion 340 of the atmospheric gas oil stream 130 can be sent to the partial hydrocracking zone 245.In some embodiments, a portion 345 of the light vacuum gas oil stream 235 can be combined with the atmospheric gas oil stream 130.The GCI fuel composition is a blend of naphtha and kerosene.", "The naphtha can comprise one or more of the hydrotreated straight run naphtha stream, hydrotreated straight run heavy naphtha stream 175, the isomerate stream 165, the butane stream 311, the reformate stream 195, the gasoline stream 313, the FCC naphtha stream 310, and the alkylate stream 293.The kerosene can comprise one or more of the kerosene streams 197 and 222, and the jet fuel streams 199 and 220.As used herein, the term about means within 10% of the value, or within 5%, or within 1%.", "While at least one exemplary embodiment has been presented in the foregoing detailed description, it should be appreciated that a vast number of variations exist.", "It should also be appreciated that the exemplary embodiment or exemplary embodiments are only examples, and are not intended to limit the scope, applicability, or configuration of the claimed subject matter in any way.", "Rather, the foregoing detailed description will provide those skilled in the art with a convenient road map for implementing an exemplary embodiment or embodiments.", "It being understood that various changes may be made in the function and arrangement of elements described in an exemplary embodiment without departing from the scope set forth in the appended claims.", "SPECIFIC EMBODIMENTS While the following is described in conjunction with specific embodiments, it will be understood that this description is intended to illustrate and not limit the scope of the preceding description and the appended claims.", "A first embodiment of the invention is a GCI fuel composition comprising a fuel blend having an initial boiling point in a range of about 26° C. to about 38° C. and a final boiling point in a range of about 193° C. to less than 250° C., a density of about 0.72 kg/l to about 0.8 kg/l at 15° C., a research octane number of about 70 to about 85, and a cetane number of less than about 27, the fuel blend comprising a naphtha stream and a kerosene stream.", "An embodiment of the invention is one, any or all of prior embodiments in this paragraph up through the first embodiment in this paragraph wherein the fuel composition has at least one of: an olefin content of the fuel composition less than about 18 lv %; an aromatic content of the fuel composition less than about 35 lv %; a sulfur content of the fuel composition less than about 10 wt ppm; and a benzene content of the fuel composition less than about 1 lv %.", "An embodiment of the invention is one, any or all of prior embodiments in this paragraph up through the first embodiment in this paragraph wherein the naphtha stream comprises at least one of a hydrotreated straight run naphtha stream; an isomerate stream; a butane stream; a reformate stream; a gasoline stream; a hydrotreated FCC naphtha stream; and an alkylate stream.", "A second embodiment of the invention is a method of making a GCI fuel composition comprising blending a naphtha stream and a kerosene stream to form a fuel blend having an initial boiling point in a range of about 26° C. to about 38° C. and a final boiling point in a range of about 193° C. to less than 250° C., a density of about 0.72 kg/l to about 0.8 kg/l at 15° C., a research octane number of about 70 to about 85, and a cetane number of less than about 27.An embodiment of the invention is one, any or all of prior embodiments in this paragraph up through the second embodiment in this paragraph wherein the naphtha stream comprises at least one of a hydrotreated straight run naphtha stream; an isomerate stream; a butane stream; a reformate stream; a gasoline stream; a hydrotreated FCC naphtha stream; and an alkylate stream.", "An embodiment of the invention is one, any or all of prior embodiments in this paragraph up through the second embodiment in this paragraph wherein the hydrotreated straight run naphtha stream is formed by hydrotreating a straight run naphtha stream.", "An embodiment of the invention is one, any or all of prior embodiments in this paragraph up through the second embodiment in this paragraph wherein the isomerate stream is formed by isomerizing at least a portion of the hydrotreated straight run naphtha stream.", "An embodiment of the invention is one, any or all of prior embodiments in this paragraph up through the second embodiment in this paragraph wherein the reformate stream is formed by reforming at least a portion of the hydrotreated straight run naphtha stream.", "An embodiment of the invention is one, any or all of prior embodiments in this paragraph up through the second embodiment in this paragraph wherein the gasoline stream comprises a blend of one or more of butane, reformate, isomerate, FCC naphtha, and alkylate.", "An embodiment of the invention is one, any or all of prior embodiments in this paragraph up through the second embodiment in this paragraph wherein the hydrotreated FCC naphtha stream is formed by fluid catalytically cracking at least one of an atmospheric gas oil stream, a vacuum gas oil stream, a coker gas oil stream, an unconverted oil stream, a light vacuum gas oil stream, or a hydrotreated gas oil stream to form an FCC stream; separating the FCC stream into the FCC naphtha stream and at least one other stream; and hydrotreating the FCC naphtha stream.", "An embodiment of the invention is one, any or all of prior embodiments in this paragraph up through the second embodiment in this paragraph wherein separating the FCC stream into the FCC naphtha stream and the at least one other stream comprises separating the FCC stream into at least the FCC naphtha stream and a FCC cycle oil stream; and hydrotreating and separating the FCC cycle oil stream into at least a hydrotreated kerosene stream.", "An embodiment of the invention is one, any or all of prior embodiments in this paragraph up through the second embodiment in this paragraph wherein the alkylate stream is formed by fluid catalytically cracking at least one of an atmospheric gas oil stream, a vacuum gas oil stream, a coker gas oil stream, an unconverted oil stream, a light vacuum gas oil stream, or a hydrotreated gas oil stream to form an FCC stream; separating the FCC stream into a C3/C4 stream and at least one other stream; separating the C3/C4 stream into at least a C3 olefin stream and a C4 stream; and alkylating at least a portion of the C3 olefin steam, the C4 stream, or both.", "An embodiment of the invention is one, any or all of prior embodiments in this paragraph up through the second embodiment in this paragraph wherein the kerosene stream is formed by at least one of separating a hydrocarbon feed stream into a first straight run kerosene stream and at least one other stream, and hydrotreating the first straight run kerosene stream; or separating a hydrocarbon feed stream into a first straight run kerosene/diesel stream and at least one other stream, and hydrotreating and separating the first straight run kerosene/diesel stream into a second straight run kerosene stream, and at least one other stream.", "An embodiment of the invention is one, any or all of prior embodiments in this paragraph up through the second embodiment in this paragraph wherein the kerosene stream is formed by at least one of hydrocracking a first atmospheric gas oil stream, and separating (and optionally hydrotreating) the hydrocracked atmospheric gas oil stream into a first kerosene stream and at least one other stream; or hydrocracking a second atmospheric gas oil stream, separating the hydrocracked atmospheric gas oil stream into a kerosene/diesel stream and at least one other stream; and separating (and optionally hydrotreating) the kerosene/diesel stream into a second kerosene stream and at least one other stream.", "An embodiment of the invention is one, any or all of prior embodiments in this paragraph up through the second embodiment in this paragraph wherein separating the hydrocracked atmospheric gas oil stream into the first kerosene stream and the at least one other stream comprises separating the hydrocracked atmospheric gas oil stream into at least the first kerosene stream, a hydrocracker heavy naphtha stream, and an unconverted oil stream.", "An embodiment of the invention is one, any or all of prior embodiments in this paragraph up through the second embodiment in this paragraph wherein separating the hydrocracked atmospheric gas oil stream into the kerosene/diesel stream and the at least one other stream comprises separating the hydrocracked atmospheric gas oil stream into at least the kerosene/diesel stream, a hydrocracker heavy naphtha stream, and an unconverted oil stream.", "An embodiment of the invention is one, any or all of prior embodiments in this paragraph up through the second embodiment in this paragraph wherein the first or second atmospheric gas oil stream is formed by separating a hydrocarbon feed stream into the first or second atmospheric gas oil stream and at least one other stream.", "An embodiment of the invention is one, any or all of prior embodiments in this paragraph up through the second embodiment in this paragraph further comprising separating a hydrocarbon feed stream into at least a straight run naphtha stream, a straight run kerosene/diesel stream, an atmospheric gas oil stream, and an atmospheric residue stream; hydrotreating the straight run naphtha stream to form a hydrotreated straight run naphtha stream; isomerizing the at least a portion of the hydrotreated straight run naphtha stream to form an isomerate stream; reforming at least a portion of the hydrotreated straight run naphtha stream to form a reformate stream; hydrotreating and separating the straight run kerosene/diesel stream into at least a hydrotreated straight run kerosene stream and at least one other stream; hydrocracking at least a portion of the atmospheric gas oil stream to form a hydrocracked stream; separating the hydrocracked stream to form at least a second kerosene/diesel stream, a hydrocracker naphtha stream, and an unconverted oil stream; separating (and optionally hydrotreating) the second kerosene/diesel stream into a second kerosene stream and at least one other stream; vacuum separating the atmospheric residue stream to form at least a light vacuum gas oil stream and a vacuum gas oil stream; optionally partially hydrocracking at least a portion of one or more of the atmospheric gas oil stream, the light vacuum gas oil, or the unconverted oil stream; fluid catalytically cracking at least one of the atmospheric gas oil stream, the vacuum gas oil stream, a coker gas oil stream, the unconverted oil stream, the light vacuum gas oil stream, or a hydrotreated gas oil stream to form an FCC stream; separating the FCC stream into at least a C3/C4 stream, a FCC naphtha stream, and a FCC cycle oil stream; and hydrotreating the FCC naphtha stream to form a hydrotreated FCC naphtha stream; hydrotreating and separating the FCC cycle oil stream into at least a third hydrotreated kerosene stream; separating the C3/C4 stream into at least a C3 olefin stream and a C4 stream; and alkylating at least a portion of the C3 olefin steam, the C4 stream, or both to form an alkylate stream; wherein the naphtha stream comprises at least one of the hydrotreated straight run naphtha stream; the isomerate stream; the reformate stream; the hydrotreated FCC naphtha stream; the alkylate stream, a butane stream, and a gasoline stream; and wherein the kerosene stream comprises at least one of the straight run hydrotreated kerosene stream; the second kerosene stream; and the third hydrotreated kerosene stream.", "An embodiment of the invention is one, any or all of prior embodiments in this paragraph up through the second embodiment in this paragraph further comprising at least one of combining at least a portion of the atmospheric gas oil stream with the light vacuum gas oil stream; and combining the hydrocracker naphtha stream with the hydrotreated straight run naphtha stream.", "The method of stream 18 further comprising coking the vacuum gas oil stream to form a coked vacuum gas oil stream; separating the coked vacuum gas oil stream into at least a coker naphtha stream, a coker gas oil stream, and a coke stream; and at least one of combining the coker gas oil stream with the light vacuum gas oil stream, or the atmospheric gas oil stream, or both; and combining the coker naphtha stream with the straight run naphtha stream.", "An embodiment of the invention is one, any or all of prior embodiments in this paragraph up through the second embodiment in this paragraph wherein the GCI fuel composition has at least one of an olefin content of the fuel composition less than about 18 lv %; an aromatic content of the fuel composition less than about 35 lv %; a sulfur content of the fuel composition less than about 10 wt ppm; and a benzene content of the fuel composition less than about 1 lv %.", "Without further elaboration, it is believed that using the preceding description that one skilled in the art can utilize the present invention to its fullest extent and easily ascertain the essential characteristics of this invention, without departing from the spirit and scope thereof, to make various changes and modifications of the invention and to adapt it to various usages and conditions.", "The preceding preferred specific embodiments are, therefore, to be construed as merely illustrative, and not limiting the remainder of the disclosure in any way whatsoever, and that it is intended to cover various modifications and equivalent arrangements included within the scope of the appended claims.", "In the foregoing, all temperatures are set forth in degrees Celsius and, all parts and percentages are by weight, unless otherwise indicated." ] ]
Patent_15872796
[ [ "Hierarchical transmission in wireless communications", "A wireless communication device includes a communication interface and a processor that operate to generate a first transmission stream by processing first information based on first parameter(s) and a second transmission stream by processing second information based on second parameter(s).", "In some examples, the second at least one parameter is relatively less robust than the first at least one parameter, and the second information augments the first information when combined with the first information.", "The wireless communication device then transmits the first transmission stream and the second transmission stream to at least one other wireless communication device.", "Examples of such parameters include forward error correction (FEC) code, error correction code (ECC), modulation coding set (MCS), modulation type including a mapping of constellation points arranged in a constellation, power (e.g., transmit (TX) power), orthogonal frequency division multiplexing (OFDM) configuration, and/or a multiple-input-multiple-output (MIMO) configuration." ], [ "1.A wireless communication device comprising: a communication interface; and processing circuitry that is coupled to the communication interface, wherein at least one of the communication interface or the processing circuitry configured to: generate a first symbol stream by processing first information based on a first at least one parameter; generate a second symbol stream by processing second information based on a second at least one parameter that is less robust than the first at least one parameter, wherein the second information augments the first information when combined with the first information; and transmit the first symbol stream and the second symbol stream to at least one other wireless communication device.", "2.The wireless communication device of claim 1, wherein at least one of: the first at least one parameter includes at least one of: a first forward error correction (FEC) code; a first error correction code (ECC); a first modulation coding set (MCS); a first modulation type including a first mapping of a first plurality of constellation points arranged in a first constellation; a first power; a first orthogonal frequency division multiplexing (OFDM) configuration; or a first multiple-input-multiple-output (MIMO) configuration; or the second at least one parameter includes at least one of: a second FEC code; a second ECC; a second MCS; a second modulation type including a second mapping of a second plurality of constellation points arranged in a second constellation; a second power; a second OFDM configuration; or a second MIMO configuration.", "3.The wireless communication device of claim 1, wherein: the first symbol stream includes a first plurality of symbols each having a first number of bits; and the second symbol stream includes a second plurality of symbols each having a second number of bits that is greater than the first number of bits.", "4.The wireless communication device of claim 1, wherein: the first information corresponds to a video stream based on a first resolution; and the second information augments the first information when combined with the first information to generate the video stream based on a second resolution that is higher than the first resolution.", "5.The wireless communication device of claim 1, wherein: the first information corresponds to an image based on a first resolution; and the second information augments the first information when combined with the first information to generate the image based on a second resolution that is higher than the first resolution.", "6.The wireless communication device of claim 1, wherein the at least one of the communication interface or the processing circuitry is further configured to: select the first at least one parameter based on a first signal to noise ratio (SNR) corresponding to a first communication pathway via which the first symbol stream is to be transmitted; and select the second at least one parameter based on a second SNR corresponding to a second communication pathway via which the second symbol stream is to be transmitted, wherein the second SNR is higher than the first SNR.", "7.The wireless communication device of claim 1 further comprising: an access point (AP), wherein the at least one other wireless communication device includes a wireless station (STA).", "8.The wireless communication device of claim 1 further comprising: a wireless station (STA), wherein the at least one other wireless communication device includes an access point (AP).", "9.A wireless communication device comprising: a communication interface; and processing circuitry that is coupled to the communication interface, wherein at least one of the communication interface or the processing circuitry configured to: generate a first symbol stream by processing first information based on a first at least one parameter, wherein the first symbol stream includes a first plurality of symbols each having a first number of bits; generate a second symbol stream by processing second information based on a second at least one parameter that is less robust than the first at least one parameter, wherein the second information augments the first information when combined with the first information, wherein the second symbol stream includes a second plurality of symbols each having a second number of bits that is greater than the first number of bits; and transmit the first symbol stream and the second symbol stream to at least one other wireless communication device, wherein the first information corresponds to media based on a first resolution, and wherein the second information augments the first information when combined with the first information to generate the media based on a second resolution that is higher than the first resolution.", "10.The wireless communication device of claim 9, wherein at least one of: the first at least one parameter includes at least one of: a first forward error correction (FEC) code; a first error correction code (ECC); a first modulation coding set (MCS); a first modulation type including a first mapping of a first plurality of constellation points arranged in a first constellation; a first power; a first orthogonal frequency division multiplexing (OFDM) configuration; or a first multiple-input-multiple-output (MIMO) configuration; or the second at least one parameter includes at least one of: a second FEC code; a second ECC; a second MCS; a second modulation type including a second mapping of a second plurality of constellation points arranged in a second constellation; a second power; a second OFDM configuration; or a second MIMO configuration.", "11.The wireless communication device of claim 9, wherein the at least one of the communication interface or the processing circuitry is further configured to: select the first at least one parameter based on a first signal to noise ratio (SNR) corresponding to a first communication pathway via which the first symbol stream is to be transmitted; and select the second at least one parameter based on a second SNR corresponding to a second communication pathway via which the second symbol stream is to be transmitted, wherein the second SNR is higher than the first SNR.", "12.The wireless communication device of claim 9 further comprising: an access point (AP), wherein the at least one other wireless communication device includes a wireless station (STA).", "13.The wireless communication device of claim 9 further comprising: a wireless station (STA), wherein the at least one other wireless communication device includes an access point (AP).", "14.A method for execution by a wireless communication device, the method comprising: generating a first symbol stream by processing first information based on a first at least one parameter; generating a second symbol stream by processing second information based on a second at least one parameter that is less robust than the first at least one parameter, wherein the second information augments the first information when combined with the first information; and transmitting, via a communication interface of the wireless communication device, the first symbol stream and the second symbol stream to at least one other wireless communication device.", "15.The method of claim 14, wherein at least one of: the first at least one parameter includes at least one of: a first forward error correction (FEC) code; a first error correction code (ECC); a first modulation coding set (MCS); a first modulation type including a first mapping of a first plurality of constellation points arranged in a first constellation; a first power; a first orthogonal frequency division multiplexing (OFDM) configuration; or a first multiple-input-multiple-output (MIMO) configuration; or the second at least one parameter includes at least one of: a second FEC code; a second ECC; a second MCS; a second modulation type including a second mapping of a second plurality of constellation points arranged in a second constellation; a second power; a second OFDM configuration; or a second MIMO configuration.", "16.The method of claim 14, wherein: the first symbol stream includes a first plurality of symbols each having a first number of bits; and the second symbol stream includes a second plurality of symbols each having a second number of bits that is greater than the first number of bits.", "17.The method of claim 14, wherein: the first information corresponds to media based on a first resolution; and the second information augments the first information when combined with the first information to generate the media based on a second resolution that is higher than the first resolution.", "18.The method of claim 14, wherein: the first information corresponds to a video stream based on a first resolution; and the second information augments the first information when combined with the first information to generate the video stream based on a second resolution that is higher than the first resolution.", "19.The method of claim 14, wherein: the first information corresponds to an image based on a first resolution; and the second information augments the first information when combined with the first information to generate the image based on a second resolution that is higher than the first resolution.", "20.The method of claim 14, wherein the wireless communication device includes an access point (AP), and the at least one other wireless communication device includes a wireless station (STA)." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS <EOH>FIG.", "1 is a diagram illustrating an embodiment of a wireless communication system.", "FIG.", "2 is a diagram illustrating an embodiment of dense deployment of wireless communication devices.", "FIG.", "3A is a diagram illustrating an example of communication between wireless communication devices.", "FIG.", "3B is a diagram illustrating another example of communication between wireless communication devices.", "FIG.", "3C is a diagram illustrating another example of communication between wireless communication devices.", "FIG.", "3D is a diagram illustrating another example of communication between wireless communication devices.", "FIG.", "3E is a diagram illustrating another example of communication between wireless communication devices.", "FIG.", "4A is a diagram illustrating an example of orthogonal frequency division multiplexing (OFDM) and/or orthogonal frequency division multiple access (OFDMA).", "FIG.", "4B is a diagram illustrating another example of OFDM and/or OFDMA.", "FIG.", "4C is a diagram illustrating another example of OFDM and/or OFDMA.", "FIG.", "4D is a diagram illustrating another example of OFDM and/or OFDMA.", "FIG.", "5A is a diagram illustrating an example of power allocation among different bit streams (e.g., encoded bit streams).", "FIG.", "5B is a diagram illustrating another example of power allocation among different bit streams (e.g., encoded bit streams).", "FIG.", "5C is a diagram illustrating an example of adaptive encoding for different transmission streams.", "FIG.", "5D is a diagram illustrating another example of adaptive encoding for different transmission streams.", "FIG.", "6A is a diagram illustrating an example of different types of modulations or modulation coding sets (MCSs) used for modulation of different bit or symbol streams.", "FIG.", "6B is a diagram illustrating an example of different labeling of constellation points in a constellation.", "FIG.", "6C is a diagram illustrating an example of different arrangements of constellation points in a type of constellation.", "FIG.", "6D is a diagram illustrating an example of adaptive symbol mapping/modulation for different transmission streams.", "FIG.", "6E is a diagram illustrating an example of adaptive symbol mapping/modulation for different transmission streams.", "FIG.", "7A is a diagram illustrating an example of constellation point distribution of a constellation points in a constellation (e.g., with different power allocations).", "FIG.", "7B is a diagram illustrating another example of constellation point distribution of a constellation points in a constellation (e.g., with different power allocations).", "FIG.", "7C is a diagram illustrating an example of different transmission streams associated with different modulations.", "FIG.", "8A is a diagram illustrating another example of different transmission streams associated with different modulations.", "FIG.", "8B is a diagram illustrating another example of different transmission streams associated with different modulations.", "FIG.", "8C is a diagram illustrating an embodiment of a method for execution by one or more wireless communication devices.", "FIG.", "8D is a diagram illustrating another embodiment of a method for execution by one or more wireless communication devices.", "FIG.", "9 is a diagram illustrating another embodiment of a method for execution by one or more wireless communication devices.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS REFERENCE TO RELATED PATENTS/PATENT APPLICATIONS The present U.S. Utility patent application claims priority pursuant to 35 U.S.C.", "§ 120 as a continuation of U.S. Utility application No.", "14/510,510, entitled “Hierarchical transmission in wireless communications,” filed Oct. 9, 2014, pending, which claims priority pursuant to 35 U.S.C.", "§ 119(e) to U.S.", "Provisional Application No.", "61/888,813, entitled “Hierarchical transmission in wireless communications,” filed Oct. 9, 2013, both of which are hereby incorporated herein by reference in their entirety and made part of the present U.S. Utility patent application for all purposes.", "BACKGROUND Technical Field The present disclosure relates generally to communication systems; and, more particularly, to hierarchical transmission and reception of communications within single user, multiple user, multiple access, and/or MIMO wireless communications.", "Description of Related Art Communication systems support wireless and wire lined communications between wireless and/or wire lined communication devices.", "The systems can range from national and/or international cellular telephone systems, to the Internet, to point-to-point in-home wireless networks and can operate in accordance with one or more communication standards.", "For example, wireless communication systems may operate in accordance with one or more standards including, but not limited to, IEEE 802.11x (where x may be various extensions such as a, b, n, g, etc.", "), Bluetooth, advanced mobile phone services (AMPS), digital AMPS, global system for mobile communications (GSM), etc., and/or variations thereof.", "In some instances, wireless communication is made between a transmitter (TX) and receiver (RX) using single-input-single-output (SISO) communication.", "Another type of wireless communication is single-input-multiple-output (SIMO) in which a single TX processes data into radio frequency (RF) signals that are transmitted to a RX that includes two or more antennae and two or more RX paths.", "Yet an alternative type of wireless communication is multiple-input-single-output (MISO) in which a TX includes two or more transmission paths that each respectively converts a corresponding portion of baseband signals into RF signals, which are transmitted via corresponding antennae to a RX.", "Another type of wireless communication is multiple-input-multiple-output (MIMO) in which a TX and RX each respectively includes multiple paths such that a TX parallel processes data using a spatial and time encoding function to produce two or more streams of data and a RX receives the multiple RF signals via multiple RX paths that recapture the streams of data utilizing a spatial and time decoding function.", "Some communication systems suffer deleteriously from interference, noise, etc.", "There may be instances in which a first device is able to communicate at a first signal to noise ratio (SNR) while a second device is able to communicate only at a second SNR that is different than the first SNR.", "Typically, communications for both the first and second devices is being tailored to the lower SNR among the first and second SNRs.", "As such, the device that is able to communicate at the relatively higher SNR is forced to communicate at the relatively lower SNR of the other device.", "The prior art does not provide an adequate solution to address these and other deficiencies.", "BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS FIG.", "1 is a diagram illustrating an embodiment of a wireless communication system.", "FIG.", "2 is a diagram illustrating an embodiment of dense deployment of wireless communication devices.", "FIG.", "3A is a diagram illustrating an example of communication between wireless communication devices.", "FIG.", "3B is a diagram illustrating another example of communication between wireless communication devices.", "FIG.", "3C is a diagram illustrating another example of communication between wireless communication devices.", "FIG.", "3D is a diagram illustrating another example of communication between wireless communication devices.", "FIG.", "3E is a diagram illustrating another example of communication between wireless communication devices.", "FIG.", "4A is a diagram illustrating an example of orthogonal frequency division multiplexing (OFDM) and/or orthogonal frequency division multiple access (OFDMA).", "FIG.", "4B is a diagram illustrating another example of OFDM and/or OFDMA.", "FIG.", "4C is a diagram illustrating another example of OFDM and/or OFDMA.", "FIG.", "4D is a diagram illustrating another example of OFDM and/or OFDMA.", "FIG.", "5A is a diagram illustrating an example of power allocation among different bit streams (e.g., encoded bit streams).", "FIG.", "5B is a diagram illustrating another example of power allocation among different bit streams (e.g., encoded bit streams).", "FIG.", "5C is a diagram illustrating an example of adaptive encoding for different transmission streams.", "FIG.", "5D is a diagram illustrating another example of adaptive encoding for different transmission streams.", "FIG.", "6A is a diagram illustrating an example of different types of modulations or modulation coding sets (MCSs) used for modulation of different bit or symbol streams.", "FIG.", "6B is a diagram illustrating an example of different labeling of constellation points in a constellation.", "FIG.", "6C is a diagram illustrating an example of different arrangements of constellation points in a type of constellation.", "FIG.", "6D is a diagram illustrating an example of adaptive symbol mapping/modulation for different transmission streams.", "FIG.", "6E is a diagram illustrating an example of adaptive symbol mapping/modulation for different transmission streams.", "FIG.", "7A is a diagram illustrating an example of constellation point distribution of a constellation points in a constellation (e.g., with different power allocations).", "FIG.", "7B is a diagram illustrating another example of constellation point distribution of a constellation points in a constellation (e.g., with different power allocations).", "FIG.", "7C is a diagram illustrating an example of different transmission streams associated with different modulations.", "FIG.", "8A is a diagram illustrating another example of different transmission streams associated with different modulations.", "FIG.", "8B is a diagram illustrating another example of different transmission streams associated with different modulations.", "FIG.", "8C is a diagram illustrating an embodiment of a method for execution by one or more wireless communication devices.", "FIG.", "8D is a diagram illustrating another embodiment of a method for execution by one or more wireless communication devices.", "FIG.", "9 is a diagram illustrating another embodiment of a method for execution by one or more wireless communication devices.", "DETAILED DESCRIPTION FIG.", "1 is a diagram illustrating an embodiment of a wireless communication system 100.The wireless communication system 100 includes base stations and/or access points 112-116, wireless communication devices 118-132 (e.g., wireless stations (STAs)), and a network hardware component 134.The wireless communication devices 118-132 may be laptop computers, or tablets, 118 and 126, personal digital assistants 120 and 130, personal computers 124 and 132 and/or cellular telephones 122 and 128.The details of an embodiment of such wireless communication devices are described in greater detail with reference to FIG.", "2.The base stations (BSs) or access points (APs) 112-116 are operably coupled to the network hardware 134 via local area network connections 136, 138, and 140.The network hardware 134, which may be a router, switch, bridge, modem, system controller, etc., provides a wide area network connection 142 for the communication system 100.Each of the base stations or access points 112-116 has an associated antenna or antenna array to communicate with the wireless communication devices in its area.", "Typically, the wireless communication devices register with a particular base station or access point 112-116 to receive services from the communication system 100.For direct connections (i.e., point-to-point communications), wireless communication devices communicate directly via an allocated channel.", "Any of the various wireless communication devices (WDEVs) 118-132 and BSs or APs 112-116 may include a processor and a communication interface to support communications with any other of the wireless communication devices 118-132 and BSs or APs 112-116.In an example of operation, a processor implemented within one of the devices (e.g., any one of the WDEVs 118-132 and BSs or APs 112-116) is configured to process at least one signal received from and/or to generate at least one signal to be transmitted to another one of the devices (e.g., any other one of the WDEVs 118-132 and BSs or APs 112-116).", "Note that general reference to a communication device, such as a wireless communication device (e.g., WDEVs) 118-132 and BSs or APs 112-116 in FIG.", "1, or any other communication devices and/or wireless communication devices may alternatively be made generally herein using the term ‘device’ (e.g., with respect to FIG.", "2 below, “device 210” when referring to “wireless communication device 210” or “WDEV 210,” or “devices 210-234” when referring to “wireless communication devices 210-234”; or with respect to FIG.", "3 below, use of “device 310” may alternatively be used when referring to “wireless communication device 310”, or “devices 390 and 391 (or 390-391)” when referring to wireless communication devices 390 and 391 or WDEVs 390 and 391).", "The processor of any one of the various devices, WDEVs 118-132 and BSs or APs 112-116, may be configured to support communications via at least one communication interface with any other of the various devices, WDEVs 118-132 and BSs or APs 112-116.Such communications may be uni-directional or bi-directional between devices.", "Also, such communications may be uni-directional between devices at one time and bi-directional between those devices at another time.", "In an example of operation, one of the devices, such as device 130, includes a communication interface and a processor that cooperatively operate to support communications with another device, such as device 116, among others within the system.", "The processor is operative to generate and interpret different signals, frames, packets, symbols, etc.", "for transmission to other devices and that have been received from other devices.", "Considering one particular type of transmission between devices, the device 130 generates an orthogonal frequency division multiplexing (OFDM) symbol (or a packet or frame that includes one or more OFDM symbols).", "The device 130 generates two or more transmission streams based on different information and different parameters.", "In one specific example, the device 130 generates a first transmission stream by processing first information based on a first at least one parameter and a second transmission stream by processing second information based on a second at least one parameter.", "The second at least one parameter is different than the first at least one parameter and can be relatively more or less robust than the first at least one parameter.", "In some instances, the second transmission stream includes entirely different information than and is unrelated to the first transmission stream.", "However, in other instances, the second transmission stream includes information that, when combined with the first information within the first transmission stream, modifies the first information.", "For example, the second transmission stream can include second information to augment the first information within the first transmission stream.", "In another example of operation, device 130 receives a first transmission stream and a second transmission stream from device 116.The device 130 processes the first transmission stream to extract first information there from.", "The device 130 processes the second transmission stream to determine whether or not second information may be successfully extracted from the second transmission stream.", "For example, the first transmission stream may be transmitted from device 116 with sufficient robustness in a noisy environment such that it is successfully received and can be successfully processed by device 130, but the second transmission stream may be transmitted from device 116 with relatively less robustness in the noisy environment such that it cannot be successfully received or processed by device 130.Depending on the determination of whether or not the second information from the second transmission stream may be recovered successfully, the device 130 generates an output signal based on either the first information only that is extracted from the first transmission stream (e.g., when the second information within the second transmission stream cannot be successfully recovered) or both the first information and the second information that are extracted from the first and second transmission streams (e.g., when the second information within the second transmission stream can be successfully recovered).", "In certain examples, the first transmission stream is transmitted with sufficiently robust parameters that it can be received and processed by device 130 even in a relatively very noisy environment.", "As such, an assumption can be made that the first transmission stream will be successfully received and processed by device 130.However, the second transmission stream may not always be successfully received and processed by device 130 (e.g., depending on the noise, interference, signal to noise ratio (SNR), signal to interference noise ratio (SINR), etc.)", "of a communication pathway between devices 116 and 130.In an example in which the second information is successfully recovered and the second information is wholly independent from the first information, the device 130 recovers both the first information and the second information and may use them for different purposes.", "In another example in which the second information is successfully recovered and the second information is related to or tied to the first information, the device 130 recovers both the first information and the second information and utilizes them together for a given purpose.", "In examples with one or more additional transmission streams, if any of the one or more additional transmission streams can be received and information recovered there from, then any information recovered from the one or more additional transmission streams may also be used in conjunction with information recovered from the first, second, and/or other one or more additional transmission streams.", "For example, a first device (e.g., device 130) may be able only to recover information from a first transmission stream, a second device (e.g., device 128) may be able to recover information from both the first transmission stream and a second transmission stream, and a third device (e.g., device 132) may be able to recover information from both the first and second transmission streams and a third transmission stream.", "As such, the first device (e.g., device 130) can generate a first output signal based on information from the first transmission stream, the second device (e.g., device 128) can generate a second output signal based on information from both the first and second transmission streams, and the third device (e.g., device 132) can generate a third output signal based on information from all of the first, second, and third second transmission streams.", "In a video signaling example, the first output signal may be 480i resolution video, the second output signal may be 720i resolution video, and the third output signal may be 1080i resolution video (e.g., such that output signals of greater or improved quality can be generated when information can be recovered from additional transmission stream(s)).", "FIG.", "2 is a diagram illustrating an embodiment 200 of dense deployment of wireless communication devices (shown as WDEVs in the diagram).", "Any of the various WDEVs 210-234 may be access points (APs) or wireless stations (STAs).", "For example, WDEV 210 may be an AP or an AP-operative STA that communicates with WDEVs 212, 214, 216, and 218 that are STAs.", "WDEV 220 may be an AP or an AP-operative STA that communicates with WDEVs 222, 224, 226, and 228 that are STAs.", "In certain instances, at least one additional AP or AP-operative STA may be deployed, such as WDEV 230 that communicates with WDEVs 232 and 234 that are STAs.", "The STAs may be any type of one or more wireless communication device types including wireless communication devices 118-132, and the APs or AP-operative STAs may be any type of one or more wireless communication devices including as BSs or APs 112-116.Different groups of the WDEVs 210-234 may be partitioned into different basic services sets (BSSs).", "In some instances, at least one of the WDEVs 210-234 are included within at least one overlapping basic services set (OBSS) that cover two or more BSSs.", "As described above with the association of WDEVs in an AP-STA relationship, one of the WDEVs may be operative as an AP and certain WDEVs of the WDEVs can be implemented within the same basic services set (BSS).", "This disclosure presents novel architectures, methods, approaches, etc.", "that allow for improved spatial re-use for next generation WiFi or wireless local area network (WLAN) systems.", "Next generation WiFi systems are expected to improve performance in dense deployments where many clients and AP are packed in a given area (e.g., which may be an area [indoor and/or outdoor] with a high density of devices, such as a train station, airport, stadium, building, shopping mall, arenas, convention centers, colleges, downtown city centers, etc.", "to name just some examples).", "Large numbers of devices operating within a given area can be problematic if not impossible using prior technologies.", "In an example of operation, devices 210 and 216 communicate with one another.", "The device 210 includes a communication interface and a processor that cooperatively operate to support communications with another device, such as device 216, among others within the system.", "The processor is operative to generate and interpret different signals, frames, packets, symbols, etc.", "for transmission to other devices and that have been received from other devices.", "Considering one particular type of transmission between devices, the device 210 generates an OFDM packet that includes one or more OFDM symbols.", "The device 210 generates two or more transmission streams by processing different information based on different parameters and transmits the two or more transmission streams to device 216.In this embodiment 200, there may be rapidly changing or varying noise, interference, SNRs, etc.", "of the various communication links between the devices.", "The device 210 generates and transmits the two or more transmission streams based on different parameters such that a first at least one of the transmission streams is transmitted in such a way of (e.g., using one or more parameters that are relatively robust) that most or all of the other devices in the system are able to receive, demodulate, and successfully recover information there from.", "The device 210 generates a second at least one transmission stream with at least one different parameter than the first at least one of the transmission stream (e.g., using one or more parameters that are relatively less robust, provide for greater throughput, greater information carrying capacity, etc.).", "A device, such as device 216, should always or almost always be able to recover information from the first at least one transmission stream successfully.", "However, there may be times in which device 216 cannot recover information from the second at least one transmission stream successfully.", "The device 210 generates an output signal based on either only the information that is extracted from the first at least one transmission stream (e.g., when information from the second at least one transmission stream cannot be successfully recovered) or information extracted from both the first and second at least one transmission streams.", "In certain examples, the first at least one transmission stream is transmitted with sufficiently robust parameters that it can be received and processed by device 210 even in a relatively very noisy environment.", "As such, an assumption can be made that the first transmission stream will be successfully received and processed by device 210.However, the second transmission stream may not always be successfully received and processed by device 210 (e.g., depending on the noise, interference, signal to noise ratio (SNR), signal to interference noise ratio (SINR), etc.)", "of a communication pathway between devices 210 and 216.FIG.", "3A is a diagram illustrating an example 301 of communication between wireless communication devices.", "A wireless communication device 310 (e.g., which may be any one of devices 118-132 as with reference to FIG.", "1) is in communication with another wireless communication device 390 via a transmission medium.", "The wireless communication device 310 includes a communication interface 320 to perform transmitting and receiving of at least one packet or frame (e.g., using a transmitter 322 and a receiver 324) (note that general reference to packet or frame may be used interchangeably).", "The wireless communication device 310 also includes a processor 330, and an associated memory 340, to execute various operations including interpreting at least one packet or frame transmitted to wireless communication device 390 and/or received from the wireless communication device 390 and/or wireless communication device 391.The wireless communication devices 310 and 390 (and/or 391) may be implemented using at least one integrated circuit in accordance with any desired configuration or combination of components, modules, etc.", "within at least one integrated circuit.", "Also, the wireless communication devices 310, 390, and 391 may each include more than one antenna for transmitting and receiving of at least one packet or frame (e.g., WDEV 390 may include m antennae, and WDEV 391 may include n antennae).", "FIG.", "3B is a diagram illustrating another example 302 of communication between wireless communication devices.", "In an example of operation, the processor 330 of device 310 generates and interprets different signals, frames, packets, symbols, etc.", "for transmission to other devices and that have been received, via communication interface 320, from other devices (e.g., device 390).", "Considering one particular type of transmission between devices, the processor 330 of device 310 generates an orthogonal frequency division multiplexing (OFDM) symbol (or a packet or frame that includes one or more OFDM symbols).", "The processor 330 generates two or more transmission streams based on different information and different parameters.", "In one specific example, the processor 330 generates a first transmission stream by processing first information based on a first at least one parameter and a second transmission stream by processing second information based on a second at least one parameter.", "The second at least one parameter is different than the first at least one parameter and can be relatively more or less robust than the first at least one parameter.", "In some instances, the second transmission stream includes entirely different information than and is unrelated to the first transmission stream.", "However, in other instances, the second transmission stream includes information that, when combined with the first information within the first transmission stream, modifies the first information.", "For example, the second transmission stream can include second information to augment the first information within the first transmission stream.", "In another example of operation, processor 330 receives a first transmission stream and a second transmission stream from processor 390.The processor 330 processes the first transmission stream to extract first information there from.", "The processor 330 processes the second transmission stream to determine whether or not second information may be successfully extracted from the second transmission stream.", "For example, the first transmission stream may be transmitted from processor 390 with sufficient robustness in a noisy environment such that it is successfully received and can be successfully processed by processor 330, but the second transmission stream may be transmitted from processor 390 with relatively less robustness in the noisy environment such that it cannot be successfully received or processed by processor 330.Depending on the determination of whether or not the second information from the second transmission stream may be recovered successfully, the processor 330 generates an output signal based on either the first information only that is extracted from the first transmission stream (e.g., when the second information within the second transmission stream cannot be successfully recovered) or both the first information and the second information that are extracted from the first and second transmission streams (e.g., when the second information within the second transmission stream can be successfully recovered).", "In certain examples, the first transmission stream is transmitted with sufficiently robust parameters that it can be received and processed by processor 330 even in a relatively very noisy environment.", "As such, an assumption can be made that the first transmission stream will be successfully received and processed by processor 330.However, the second transmission stream may not always be successfully received and processed by processor 330 (e.g., depending on the noise, interference, signal to noise ratio (SNR), signal to interference noise ratio (SINR), etc.)", "of a communication pathway between devices 310 and 390.Some examples of some parameters used to generate transmission streams include forward error correction (FEC) code, error correction code (ECC), modulation coding set (MCS), modulation type including a mapping of constellation points arranged in a constellation, power (e.g., transmit (TX) power), orthogonal frequency division multiplexing (OFDM) configuration, and/or a multiple-input-multiple-output (MIMO) configuration.", "The first and second transmission streams may vary by as few as one parameter or as many as all parameters.", "For example, the first transmission stream may be based on any one or more of a first FEC code, a first ECC, a first MCS, a first modulation type including a first mapping of first constellation points arranged in a first constellation, a first power, first OFDM configuration, and the second transmission stream may be based on any one or more of a second FEC code, a second ECC, a second MCS, a second modulation type including a second mapping of second constellation points arranged in a second constellation, a second power, second OFDM configuration, and/or second MIMO configuration.", "Examples of FEC codes or ECCs may include turbo code, convolutional code, turbo trellis coded modulation (TTCM), low density parity check (LDPC) code, Reed-Solomon (RS) code, BCH (Bose and Ray-Chaudhuri, and Hocquenghem) code, binary convolutional code (BCC), etc.", "Examples of MCSs may include any of a variety of different combinations of modulation, symbol mapping, etc.", "such as within various communication protocols, standards, and/or recommended practices (e.g., MCS0, MCS1, etc.).", "Examples of modulation types may include constellations of a particular type or shape quadrature phase shift keying (QPSK), 16 QAM, M-QAM (e.g., where M=64, 256, etc.)", "etc.", "among other types of modulation, and may specify particular constellation point labeling within those constellations.", "Examples of powers, such as transmission powers, can include a first transmission power, second transmission power, etc.", "Examples of OFDM configurations can include identification of one or more frequency bands, one or more channels within the one or more frequency bands, number of sub-carriers, spacing between such sub-carriers, any OFDM framing, number of symbols within such OFDM framing, and/or any other related characteristic dealing with OFDM.", "Examples of MIMO configurations may include specifying which antenna are to transmit certain transmission streams, a number of streams, a number of space time streams, a type of beamforming performed by the antennas, transmit powers of the antennas, antenna weight vectors (AWVs), etc.", "and/or any other related characteristic dealing with MIMO configuration.", "The processor 330 may generate the second transmission stream using certain parameters relative to the first transmission stream that are relatively less robust yet provide for a greater throughput of information.", "For example, when generating the second transmission stream relative to the first transmission stream, the processor 330 uses a second FEC code that is relatively less robust and has relatively higher code rate than the first FEC of the first transmission stream or a second ECC that is relatively less robust and has relatively higher code rate than the first ECC of the first transmission stream.", "In another example, when generating the second transmission stream, the processor 330 uses a second MCS that is relatively less robust and provides for relatively higher throughput than the first MCS of the first transmission stream.", "In another example, when generating the second transmission stream, the processor 330 generates symbols based on a modulation having relatively more constellation points than used for the first transmission stream and symbols within the second transmission stream include relatively more bits per symbol than the symbols within the first transmission stream.", "In another example, when transmitting the second transmission stream, the processor 330 transmits, via the communication interface 320, the second transmission stream with relatively lower power than the first transmission stream.", "In such an example, the processor 330 transmits, via the communication interface 320, the first transmission stream at a relatively higher power to provide for a greater probability that the first transmission stream will be successfully received by the recipient device, such as device 390.In some examples, the operations shown within FIG.", "3C, FIG.", "3D, FIG.", "3E can be viewed as being performed at or during three successive periods of time (e.g., FIG.", "3C at or during a first time, FIG.", "3D at or during a second time, and FIG.", "3 at or during a third time).", "FIG.", "3C is a diagram illustrating another example 303 of communication between wireless communication devices.", "In this diagram, the device 310 generates and transmits a first transmission stream and a second transmission stream to one or more other devices 390-391.The first transmission stream is generated by processing first information based on a first at least one parameter, and the second transmission stream is generated by processing second information based on a second at least one parameter.", "The first and second transmission streams may be wholly independent from one another or related such that second information within the second transmission stream modifies or augments the first information within the first transmission stream.", "In certain examples, device 310 generates and transmits the first transmission stream using the first at least one parameter that is selected to ensure that all of devices 390-391 will be able successfully to recover the first information therein (e.g., first at least one parameter selected based on at least one characteristic of a first communication pathway such as noise, interference, SNR, SINR, etc.", "), and the device 310 generates and transmits a second transmission stream using the second at least one parameter that is selected based on a relatively lower robustness and higher throughput and such that at least one, though perhaps not all in some instances, of the devices 390 through 391 will be able successfully recovered the second information therein (e.g., second at least one parameter selected based on at least one characteristic of a second communication pathway such as noise, interference, SNR, SINR, etc.).", "FIG.", "3D is a diagram illustrating another example 304 of communication between wireless communication devices.", "In this diagram, one or both of devices 390-391 provides feedback information to device 310.This feedback information may be related to channel estimation, channel characterization, noise estimation, interference estimation, inter-symbol interference (ISI), signal to noise ratio (SNR), signal to interference noise ratio (SINR), and/or any other feedback information including characterization of the communication pathway between the device providing the feedback information and device 310.For example, device 390 may provide first feedback information to device 310 relating to the communication pathway between devices 390 and 310, and device therein anyone may provide second feedback information to device 310 relating to the communication pathway between devices 390 and 310.FIG.", "3E is a diagram illustrating another example 305 of communication between wireless communication devices.", "In this diagram, relative to the diagram of FIG.", "3C, the device 310 generates and transmits a first transmission stream and a second transmission stream to one or more other devices 390-391 but using at least one different parameter than is used in FIG.", "3C.", "For example, based on feedback information received from one or both of devices 390-391, device 310 can modify at least one parameter used to generate one or both of the first and second transmission streams.", "Generally speaking, different transmission streams may be adapted and changed over time based on information related to local and/or remote operating conditions relative to device 310, local and/or remote operating conditions relative to devices 390-391, etc.", "Note that device 310 can generate the first and second transmission streams based on any of a variety of different signaling schemes (e.g., orthogonal frequency division multiplexing (OFDM), orthogonal frequency division multiple access (OFDMA), multi-user multiple-input-multiple-output (MU-MIMO), single-user multiple-input-multiple-output (SU-MIMO), etc.).", "In one example, device 310 employs OFDM signaling.", "Some information regarding OFDM and/or OFDMA is provided below.", "FIG.", "4A is a diagram illustrating an example 401 of orthogonal frequency division multiplexing (OFDM) and/or orthogonal frequency division multiple access (OFDMA).", "OFDM's modulation may be viewed as dividing up an available spectrum into a plurality of narrowband sub-carriers (e.g., relatively lower data rate carriers).", "The sub-carriers are included within an available frequency spectrum portion or band.", "This available frequency spectrum is divided into the sub-carriers or tones used for the OFDM or OFDMA symbols and packets/frames.", "Typically, the frequency responses of these sub-carriers are non-overlapping and orthogonal.", "Each sub-carrier may be modulated using any of a variety of modulation coding techniques (e.g., as shown by the vertical axis of modulated data).", "A communication device may be configured to perform encoding of one or more bits to generate one or more coded bits used to generate the modulation data (or generally, data).", "For example, a processor of a communication device may be configured to perform forward error correction (FEC) and/or error correction code (ECC) of one or more bits to generate one or more coded bits.", "Examples of FEC and/or ECC may include turbo code, convolutional code, turbo trellis coded modulation (TTCM), low density parity check (LDPC) code, Reed-Solomon (RS) code, BCH (Bose and Ray-Chaudhuri, and Hocquenghem) code, etc.", "The one or more coded bits may then undergo modulation or symbol mapping to generate modulation symbols.", "The modulation symbols may include data intended for one or more recipient devices.", "Note that such modulation symbols may be generated using any of various types of modulation coding techniques.", "Examples of such modulation coding techniques may include binary phase shift keying (BPSK), quadrature phase shift keying (QPSK), 8-phase shift keying (PSK), 16 quadrature amplitude modulation (QAM), 32 amplitude and phase shift keying (APSK), etc., uncoded modulation, and/or any other desired types of modulation including higher ordered modulations that may include even greater number of constellation points (e.g., 1024 QAM, etc.).", "FIG.", "4B is a diagram illustrating another example 402 of OFDM and/or OFDMA.", "A transmitting device transmits modulation symbols via the sub-carriers.", "OFDM and/or OFDMA modulation may operate by performing simultaneous transmission of a large number of narrowband carriers (or multi-tones).", "In some applications, a guard interval (GI) or guard space is sometimes employed between the various OFDM symbols to try to minimize the effects of ISI (Inter-Symbol Interference) that may be caused by the effects of multi-path within the communication system, which can be particularly of concern in wireless communication systems.", "In addition, a CP (Cyclic Prefix) and/or cyclic suffix (CS) (shown in right hand side of FIG.", "4A) that may be a copy of the CP may also be employed within the guard interval to allow switching time, such as when jumping to a new communication channel or sub-channel, and to help maintain orthogonality of the OFDM and/or OFDMA symbols.", "Generally speaking, an OFDM and/or OFDMA system design is based on the expected delay spread within the communication system (e.g., the expected delay spread of the communication channel).", "In a single-user system in which one or more OFDM symbols or OFDM packets/frames are transmitted between a transmitter device and a receiver device, all of the sub-carriers or tones are dedicated for use in transmitting modulated data between the transmitter and receiver devices.", "In a multiple user system in which one or more OFDM symbols or OFDM packets/frames are transmitted between a transmitter device and multiple recipient or receiver devices, the various sub-carriers or tones may be mapped to different respective receiver devices as described below with respect to FIG.", "4C.", "FIG.", "4C is a diagram illustrating another example 403 of OFDM and/or OFDMA.", "Comparing OFDMA to OFDM, OFDMA is a multi-user version of the popular orthogonal frequency division multiplexing (OFDM) digital modulation scheme.", "Multiple access is achieved in OFDMA by assigning subsets of subcarriers to individual recipient devices or users.", "For example, first sub-carrier(s)/tone(s) may be assigned to a user 1, second sub-carrier(s)/tone(s) may be assigned to a user 2, and so on up to any desired number of users.", "In addition, such sub-carrier/tone assignment may be dynamic among different respective transmissions (e.g., a first assignment for a first packet/frame, a second assignment for second packet/frame, etc.).", "An OFDM packet/frame may include more than one OFDM symbol.", "Similarly, an OFDMA packet/frame may include more than one OFDMA symbol.", "In addition, such sub-carrier/tone assignment may be dynamic among different respective symbols within a given packet/frame or superframe (e.g., a first assignment for a first OFDMA symbol within a packet/frame, a second assignment for a second OFDMA symbol within the packet/frame, etc.).", "Generally speaking, an OFDMA symbol is a particular type of OFDM symbol, and general reference to OFDM symbol herein includes both OFDM and OFDMA symbols (and general reference to OFDM packet/frame herein includes both OFDM and OFDMA packets/frames, and vice versa).", "FIG.", "4C shows example 403 where the assignments of sub-carriers to different users are intermingled among one another (e.g., sub-carriers assigned to a first user includes non-adjacent sub-carriers and at least one sub-carrier assigned to a second user is located in between two sub-carriers assigned to the first user).", "The different groups of sub-carriers associated with each user may be viewed as being respective channels of a plurality of channels that compose all of the available sub-carriers for OFDM signaling.", "FIG.", "4D is a diagram illustrating another example 404 of OFDM and/or OFDMA.", "In this example 404, the assignments of sub-carriers to different users are located in different groups of adjacent sub-carriers (e.g., first sub-carriers assigned to a first user include first adjacently located sub-carrier group, second sub-carriers assigned to a second user include second adjacently located sub-carrier group, etc.).", "The different groups of adjacently located sub-carriers associated with each user may be viewed as being respective channels of a plurality of channels that compose all of the available sub-carriers for OFDM signaling.", "Generally, a communication device may be configured to include a processor configured to process received OFDM or OFDMA symbols and/or frames and to generate such OFDM or OFDMA symbols and/or frames.", "Note that general reference to OFDM herein, such as with respect to an OFDM packet, may be adapted to include OFDM or OFDMA.", "The processor of any communication device described herein may be implemented to generate an OFDM packet based on any of the examples, embodiments, or variants described herein.", "That communication device may then be implemented to transmit such an OFDM packet to another communication device.", "This disclosure presents hierarchical transmission mechanisms for wireless communications that enable at least a portion of the information carried in a packet to be received successfully with higher probability than others.", "In comparison to prior art approaches, current transmission modes based on prior IEEE 802.11 standards, protocols, and/or recommended practices operates based on an all or nothing approach (e.g., a transmission is either received successfully or not, and a re-transmission of the entire packet must occur when not received successfully).", "This disclosure also presents approaches to improve performance of wireless communications when high levels or fluctuation of overlapping basic services set (OBSS) interference occurs.", "In this case, changes in the predicted signal to interference noise ratio (SINR) occur even mid-packet and make it harder for the link adaptation to converge to the right modulation coding set (MCS) or number of spatial streams (e.g., in next generation type IEEE 802.11 systems such as described with reference to FIG.", "3).", "In such an environment, a wireless communication device (e.g., receiver) can employ techniques to be able to decode a portion of the information if the SINR drops lower (e.g., than some threshold) and the full information if SINR is high are very useful.", "However, note that a penalty or reduction of performance may be incurred since the SINR required to decode the full information is higher than the SINR required under normal currently used transmissions in existing IEEE 802.11 standards, protocols, and/or recommended practices.", "A wireless communication device may be configured to choose the transmission parameters carefully depending on feedback signal over a period of time for a given communication link (e.g., from a receiver wireless communication device) as each communication link may experience different levels of interference with different fluctuation over time.", "Multi-layered transmission splits the information (e.g., which can be encoded information, uncoded information, and/or any combination thereof) into 2 or more bit streams where the first stream is mapped to the more robust layer (e.g., requiring lower SINR to decode) and the second stream is mapped to the less robust layer (e.g., requiring higher SINR to decode).", "Two techniques are described below as follows: 1.Use of 2 or more encoded streams superposed over each other with different power allocation (e.g.", "the second stream can be 10 dB weaker to enable robust decoding of the first stream which is designed to work at SINR<10 dB).", "Users first decode the more robust stream.", "Users with high SINR can decode the second stream by subtracting the first.", "The power allocation ratio is a system tradeoff that is determined based on the expected signal coverage—lowest signal to noise ratio (SNR) expected to highest SNR expected such that all users can decode the baseline layer and a high percentage of users can decode the second layer and is signaled in the SIG field (e.g.", "4 bits denoting a certain range from 3 dB to 15 dB).", "Note that usage of multiple streams can be used in conjunction with one or more antennas at the transmit and receive side (e.g., such as using wireless communication devices 410 and 490 with any desired numbers of antennas).", "2.Use of stretched modulation symbols (e.g., QAM symbols) where each quadrant constellation point is shifted away from the origin (0,0) point.", "A user with lower SNR only decodes the correct quadrant (the 2 most reliable bits of the QAM symbol) that provides a portion of the information.", "A user with higher SNR can decode all QAM points.", "Similarly to the previous method the stretching level is determined by the system depending on the SNR expected.", "Note also that any desired type of modulation or modulations may be used and be scaled accordingly (e.g., 4-QAM/QPSK, 8-phase shift keying (PSK), 32 amplitude and phase shift keying (APSK), 64-QAM, 128-QAM, 256-QAM, etc.", "and/or even higher ordered modulations including larger numbers of constellation points).", "FIG.", "5A is a diagram illustrating an example 501 of power allocation among different bit streams (e.g., encoded bit streams).", "At least two different bit streams (e.g., encoded streams) are mapped to different layers (e.g., having one or more different operational parameters).", "The multi-layered transmission splits the information (e.g., which can be encoded information, uncoded information, and/or any combination thereof) into 2 or more bit streams where the first stream is mapped to the more robust layer (e.g., requiring lower SINR to decode) and the second stream is mapped to the less robust layer (e.g., requiring higher SINR to decode).", "In some embodiments, there can be additional streams (e.g., up to n).", "In FIG.", "5A, a first stream is mapped to a first layer having a first power allocation, and a second stream is mapped to a second layer having a second power allocation.", "In some embodiments, another stream n is mapped to another layer n having an n-th power allocation.", "FIG.", "5B is a diagram illustrating another example 502 of power allocation among different bit streams (e.g., encoded bit streams).", "The respective streams (e.g., 1, 2, and so on up to n) are mapped differently than in FIG.", "5A.", "In FIG.", "5B, the first stream is mapped to a first layer having a first modified power allocation (e.g., different than the first power allocation), and a second stream is mapped to a second layer having a second modified power allocation (e.g., different than the second power allocation).", "In some embodiments, another stream n is mapped to another layer n having an n-th modified power allocation (e.g., different than the n-th power allocation).", "A wireless communication device may be configured to perform adaptive power allocation among 2 or more streams at different times based on any desired considerations.", "Multi-Layer Transmission (e.g., for Video Applications) Multi-layered transmission can be used to provide higher throughput to devices with better link (e.g., with communication pathways with higher SNR or SINR, lower noise, lower interference, etc.", "or generally a communication link that allows for communications based on relatively less robust and/or higher throughput parameters).", "These techniques are usually coupled with splitting the video transmission to 2 or more bit streams where the first stream provides a baseline video quality and is mapped to the more robust layer and the second stream provides higher resolution video quality (e.g., 15 frames per second (fps) vs. 30 or 60 fps) or standard definition television (SDTV) resolution vs. high definition television (HDTV) vs. 8K HDTV resolution) and is mapped to the less robust layer.", "Two techniques are described as follows: 1.Use of 2 or more encoded streams superposed over each other with different power allocation (e.g., the second stream can be 10 dB weaker to enable robust decoding of the first stream which is designed to work at signal to interference noise ratio (SINR)<10 dB).", "Receiver wireless communication devices (e.g., users) first decode the more robust stream.", "Those receiver wireless communication devices (e.g., users) with high SNR can decode the second stream by subtracting the first.", "The power allocation ratio is a system tradeoff that is determined based on the expected signal coverage as defined in terms of the lowest SNR expected to highest SNR expected such that all users can decode the baseline layer and a high percentage of users can decode the second layer and is signaled in the SIG field (e.g., 4 bits denoting a certain range from 3 dB to 15 dB).", "Note that usage of multiple streams can be used in conjunction with one or more antennas at the transmit and receive sides.", "2.Use of stretched quadrature amplitude modulation (QAM) symbols where each quadrant constellation point is shifted away from the origin (0,0) point.", "A user with lower SNR only decodes the correct quadrant (the 2 most reliable bits of the QAM symbol) that provides the baseline video quality.", "A user with higher SNR can be able to decode all QAM points.", "Similarly to the previous method the stretching level is determined by the system depending on the SNR expected.", "FIG.", "5C is a diagram illustrating an example 503 of adaptive encoding for different transmission streams.", "In this diagram, a processor of a device (e.g., processor 330 of device 310) is implemented to perform encoding processing using any one or more of different types of FEC codes or ECCs.", "The processor generates two or more encoded streams based on the various FEC codes or ECCs.", "In some examples, two or more encoded streams are based on the same FEC code or ECC.", "In other examples, two or more encoded streams are based on different FEC codes or ECCs.", "In this example, at or during a first time, the processor generates a first encoded stream based on low density parity check (LDPC) code, and a second encoded stream based on Reed-Solomon (RS) code.", "Generally, any number of additional encoded streams may be generated based on any one or more FEC codes or ECCs (e.g., up to an n-th encoded stream based on turbo code).", "Note that these encoded streams subsequently undergo appropriate processing to generate transmission streams for transmission to one or more other devices (e.g., including processing such as that performed by an analog front end (AFE) which may include digital to analog conversion, scaling, frequency shifting, filtering, etc.).", "FIG.", "5D is a diagram illustrating another example 504 of adaptive encoding for different transmission streams.", "The operations of this diagram may be viewed as being at or during a different time than the first time of FIG.", "5C.", "Based on one or more considerations, the processor adapts one or more of the FEC codes or ECCs used to generate the two or more encoded streams.", "For example, based on feedback provided from a recipient device to which the two or more encoded streams of FIG.", "5C have been transmitted, the processor selects different one or more FEC codes or ECCs to generate the two or more encoded streams.", "In this example, at or during a second time, the processor generates the first encoded stream based on BCH (Bose and Ray-Chaudhuri, and Hocquenghem) code.", "Generally speaking adaptation between different FEC codes or ECCs may be made for the various encoded streams at different times based on different criteria.", "FIG.", "6A is a diagram illustrating an example 601 of different types of modulations or modulation coding sets (MCSs) used for modulation of different bit or symbol streams.", "Information, data, etc.", "may be modulated using various modulation coding techniques.", "Examples of such modulation coding techniques may include binary phase shift keying (BPSK), quadrature phase shift keying (QPSK) or quadrature amplitude modulation (QAM), 8-phase shift keying (PSK), 16 quadrature amplitude modulation (QAM), 32 amplitude and phase shift keying (APSK), 64-QAM, etc., uncoded modulation, and/or any other desired types of modulation including higher ordered modulations that may include even greater number of constellation points (e.g., 1024 QAM, etc.).", "Generally, a device that generates two or more transmission streams based on different parameters can generate a first transmission stream based on a first at least one parameter such as a first MCS that is relatively more robust and provides for relatively lower throughput than a second transmission stream based on a second at least one parameter such as a second MCS that is relatively less robust and provides for relatively higher throughput.", "Relatively lower-ordered modulation/MCS (e.g., relatively fewer bits per symbol, relatively fewer constellation points per constellation, etc.)", "may be used for the first transmission stream to ensure reception by a recipient device and so that the recipient device can successfully recover information therein (e.g., being relatively more robust, easier to demodulate, decode, etc.).", "Relatively higher-ordered modulation/MCS (e.g., relatively more bits per symbol, relatively more constellation points per constellation, etc.)", "may be used for the second transmission stream so that any recipient device that can successfully recover information there from can use it as well.", "This second information within the second transmission stream may be separate and independent from first information included within the first transmission stream or may be intended for use in conjunction with the first information included within the first transmission stream.", "FIG.", "6B is a diagram illustrating an example 602 of different labeling of constellation points in a constellation.", "This diagram uses an example of a QPSK/QAM shaped constellation having different labeling of the constellation points therein that may be used at different times.", "In an example operation, a device generates a transmission stream based on the labeling 1 at or during a first time and based on the labeling 2 at or during a second time.", "The particular labeling of constellation points within a constellation is one example of a parameter that may be used to generate a transmission stream and that may change and vary over time.", "FIG.", "6C is a diagram illustrating an example 603 of different arrangements of constellation points in a type of constellation.", "This diagram also uses an example of a QPSK/QAM shaped constellation but with varying placement of the four constellation points based on different forms of QPSK (e.g., QPSK1, QPSK2, and QPSK3).", "Note that the relative distance of the four constellation points may be scaled differently at different times, yet such that each constellation point is included within a separate quadrant.", "Comparing QPSK2 to QPSK1, the constellation points of QPSK2 are relatively further from the origin than QPSK1.Comparing QPSK3 to QPSK2, the constellation points of QPSK3 are shifted up or down relative to QPSK2.Note that any other type of shape of constellation may similarly be varied based on the principles described with respect to FIG.", "6B and FIG.", "6C.", "For example, the labeling and or placement of the constellation points within a 8-PSK type constellation, a 16 QAM type constellation, and/or any other type constellation may change in very as a function of time based on any desired consideration as well.", "FIG.", "6D is a diagram illustrating an example 604 of adaptive symbol mapping/modulation for different transmission streams.", "In this diagram, a processor of a device (e.g., processor 330 of device 310) is implemented to perform symbol mapping or modulation based on different modulations, symbol mappings, MCSs, etc.", "at or during different times.", "In some examples, two or more encoded streams are based on the same modulation, symbol mapping, MCS, etc.", "In other examples, two or more encoded streams are based on different modulations, symbol mappings, MCSs, etc.", "In this example, at or during a first time, the processor generates a first symbol stream based on a first QAM/QPSK mode (e.g., QPSK1 of FIG.", "6C) and a second symbol stream based on a second QAM/QPSK mode (e.g., QPSK2 of FIG.", "6C).", "Generally, any number of additional symbol streams may be generated based on any one or more modulations, symbol mappings, MCSs, etc.", "(e.g., up to an n-th symbol stream based on 16 QAM).", "Note that these symbol streams subsequently undergo appropriate processing to generate transmission streams for transmission to one or more other devices (e.g., including processing such as that performed by an analog front end (AFE) which may include digital to analog conversion, scaling, frequency shifting, filtering, etc.).", "FIG.", "6E is a diagram illustrating an example 605 of adaptive symbol mapping/modulation for different transmission streams.", "The operations of this diagram may be viewed as being at or during a different time than the first time of FIG.", "6D.", "Based on one or more considerations, the processor adapts one or more of the modulations, symbol mappings, MCSs, etc.", "used to generate the two or more symbol streams.", "For example, based on feedback provided from a recipient device to which the two or more encoded streams of FIG.", "6D have been transmitted, the processor selects different one or more modulations, symbol mappings, MCSs, etc.", "to generate the two or more symbol streams.", "In this example, at or during a second time, the processor generates the first symbol stream based on 16 QAM, the second symbol stream based on 64 QAM, and optional an n-th symbol stream based on 256 QAM.", "FIG.", "7A is a diagram illustrating an example 701 of constellation point distribution of a constellation points in a constellation (e.g., with different power allocations).", "Generally, a 16-QAM modulation includes 16 constellation points, and each constellation point corresponds to a respective 4-bit label or 4-bit symbol (e.g., 0000, 0001, 0010, and so on up to 1111).", "FIG.", "7B is a diagram illustrating another example 702 of constellation point distribution of a constellation points in a constellation (e.g., with different power allocations).", "Relative to FIG.", "7A, this variant 16 QAM constellation includes constellation points that are extended out relative to the constellation points of FIG.", "7A.", "FIG.", "7B depicts constellation points of both 16 QAM shaped constellations (e.g., one having constellation points extended out relative to the other).", "FIG.", "7B has a larger gap requiring much higher SNR to decode all bits but needing lower SNR to decode the un-stretched constellation points.", "In a specific example using FIG.", "7B, the constellation plot of this diagram shows two examples of stretched 16 QAM where 2 bits are used mapped to the correct quadrant (shown as the hashed constellation points and identified as QPSK1/QAM1) and are relatively more robust then the 2 bits that are used to map to a specific point within the quadrant (shown as the empty constellation points and identified as QPSK2/QAM2).", "For example, a first transmission stream may include 2 bits symbols that identify the particular quadrant of interest such as being centrally located within a cluster of four other constellation points in each quadrant.", "This first transmission stream will map each symbol therein to one of the four hashed constellation points that is identified as QPSK1/QAM1.A second transmission stream may also include 2 bits symbols.", "The second transmission stream will map each symbol therein to one of the four empty constellation points that is identified as QPSK2/QAM2 that are clustered around the identified hashed constellation point that has been identified from the first transmission stream using QPSK1/QAM1.FIG.", "7C is a diagram illustrating an example 703 of different transmission streams associated with different modulations.", "In this diagram, a first transmission stream includes 2 bits symbols as identified by the hashed constellation points as QPSK1/QAM1 and each symbol of the first transmission stream includes information and also identifies a particular one of the four quadrants.", "A first transmission stream includes 4 bits symbols as identified by the empty constellation points as 16 QAM that are clustered around each of the four constellation points associated with the first transmission stream.", "A recipient device that is able to recover first information from the first transmission stream can use that first information.", "When the recipient device is able to recover information from the second transmission stream, the device can use that second information as well (e.g., either in for use in conjunction with the first information or separately from the first information).", "In a first specific example, the first information included within the first transmission stream corresponds to 480i or 480p resolution video, and the second information included within the second transmission stream corresponds to 1080i or 1080p resolution video.", "In a second specific example, the first information included within the first transmission stream corresponds to 480i or 480p resolution video, and the second information included within the second transmission stream, when combined with the first information recovered from the first transmission stream, corresponds to 1080i or 1080p resolution video (e.g., the device combines the first information and the second information to recover the 1080i or 1080p resolution video).", "Note that using different transmission streams to convey video of different resolutions is just one example of use for such hierarchical transmission is described herein.", "Any of a variety of types of information may be transmitted via the different transmission streams (e.g., any type of media including images, video, audio, etc., any type of data including files, e-mails, text messages, etc., and/or any other type of information that may be transmitted between devices within a communication system).", "Note that other types of modulations may be used for different transmission streams or the same type of modulation may be used for different transmission streams.", "For example, as shown with respect to FIG.", "7B, both a first and a second transmission stream use a QPSK type constellation such that symbols of the second transmission stream are mapped around a particular QPSK constellation that is identified by a centrally located constellation point from information recovered from the first transmission stream.", "Note that any types of combinations of different modulations may be used for the different transmission streams (e.g., example 1: QPSK for the first transmission stream and 8-PSK for the second transmission stream; example 2: 8-PSK for the first transmission stream and QPSK for the second transmission stream; example 3: 16 QAM for the first transmission stream and QPSK for the second transmission stream; etc.).", "FIG.", "8A is a diagram illustrating another example 801 of different transmission streams associated with different modulations.", "FIG.", "8B is a diagram illustrating another example 802 of different transmission streams associated with different modulations.", "These figures, FIGS.", "8A and 8B, show different constellation point distributions of a particular modulation (e.g., with different power allocations).", "The plots in these diagrams show two specific examples of a 16 QAM modulation and also show the relative magnitudes of the in-phase (I) and quadrature (Q) axes.", "One of the modulations is stretched 16 QAM (FIG.", "8B) where 2 bits are mapped to the quadrant and are more robust and 2 bits mapped to the specific point within the quadrant.", "FIG.", "8A uses lower stretching level leading to smaller gap between the two groups of bits.", "FIG.", "8B has a larger gap requiring much higher SNR to decode all bits but needing lower SNR to decode the un-stretched constellation points.", "The stretching factor is a system parameter (e.g., one of the parameters by which a device generates transmission streams), similarly to one or more multi-layer transmissions, that may be selected or optimized for one or more specific applications or deployments.", "Such information may be signaled in a particular field of a packet or frame (e.g., a signal field (SIG) field of an OFDM packet communication).", "The current acknowledgement (ACK) needs to be expanded to support feedback of the number of layers received correctly.", "For example, in a 2 layer hierarchical transmission, a receiver wireless communication device (e.g., wireless station (STA)) may ACK reception of the base layer only or both layers.", "Based on the feedback, the transmitter can decide whether to use the regular transmission mode or hierarchical transmission mode.", "For example, wireless communication devices or users that are close to an access point (AP), and those wireless communication devices don't experience large SNR fluctuations may use the regular transmission mode.", "Users at the cell edge or coverage region edge are more likely to use hierarchical transmission mode.", "Referring again to these figures, FIG.", "8A and 8B, FIG.", "8A uses lower stretching level leading to smaller gap between the two groups of bits.", "FIG.", "8B has larger gap requiring much higher SNR to decode all bits but needing lower SNR to decode the un-stretched constellation points.", "Similar to the multi-layer transmission the stretching factor is a system parameter optimized for a specific deployments and signaled in the SIG field.", "Determination of Modulation Coding Set (MCS) Whether a communication system operates using a single MCS single layer transmission scheme or a multi-layer transmission scheme as described herein, the MCS and the multi-layer transmission parameters need to be determined.", "At least three novel ways to perform this are presented herein.", "Any one of these three ways can be used to augment another one of the other three: 1.A-priori knowledge about the deployment (AP density, path loss) can enable prediction of the parameters (collecting location information using location queries or geolocation protocol, such as global positioning system (GPS)).", "This may correspond to the location of APs and clients (e.g., STAs).", "2.Feedback (RSSI, recommended MCS) of unicast (UCAST) transmissions (management frames, ACKs response) may be used.", "The aggregated power of all APs is predicted/accounted for.", "For example, the received power for every STA from all APs maybe summed up to predict received power in broadcast mode.", "3.Feedback of actual broadcast transmissions may be used.", "The system could start from more robust parameters and progress based on feedback.", "FIG.", "8C is a diagram illustrating an embodiment of a method 803 for execution by one or more wireless communication devices.", "The method 803 begins by generating a first transmission stream by processing first information based on a first at least one parameter (block 810).", "The method 803 continues by generating a second transmission stream by processing second information based on a second at least one parameter that is relatively less robust than the first at least one parameter (block 820).", "In one example, the second information augments the first information when combined with the first information.", "In another example, the first and second information are wholly independent from one another.", "The method 803 then operates by transmitting, via a communication interface of the wireless communication device, the first transmission stream and the second transmission stream to at least one other wireless communication device (block 830).", "FIG.", "8D is a diagram illustrating another embodiment of a method 804 for execution by one or more wireless communication devices.", "The method 804 begins by generating a first transmission stream corresponding to 480p video (block 811).", "The method 804 continues by generating a second transmission stream corresponding to 1080i video (block 821).", "In some examples, the second transmission stream, when combined with the first transmission stream, corresponds to 1080i video.", "The method 804 then operates by transmitting, via a communication interface of the wireless communication device, the first transmission stream and the second transmission stream to at least one other wireless communication device (block 831).", "FIG.", "9 is a diagram illustrating another embodiment of a method 900 for execution by one or more wireless communication devices.", "The method 900 begins by receiving a first transmission stream from another wireless communication device, wherein the first transmission stream includes first information that is based on a first at least one parameter (block 910).", "The method 900 continues by receiving a second transmission stream from the other wireless communication device (block 920).", "In one example, the second transmission stream includes second information that is based on a second at least one parameter.", "In another example, the first and second transmission streams are independent from one another.", "The method 900 then operates by processing the first transmission stream to extract the first information there from (block 930).", "The method 900 continues by processing the second transmission stream to determine whether the second information may be successfully extracted from the second transmission stream (block 940).", "When it is determined that the second information may be successfully extracted from the second transmission stream (block 950), the method 900 continues by processing the second transmission stream to extract the first information there from and generate a first output signal based on both the first information and the second information (block 960).", "Alternatively, when it is determined that the second information cannot be successfully extracted from the second transmission stream (block 950), the method 900 then operates by generating a second output signal based on only the first information (block 970).", "It is noted that the various operations and functions described within various methods herein may be performed within a wireless communication device (e.g., such as by the processor 330, communication interface 320, and memory 340 as described with reference to FIG.", "3A) and/or other components therein.", "Generally, a communication interface and processor in a wireless communication device can perform such operations.", "Examples of some components may include one of more baseband processing modules, one or more media access control (MAC) layer components, one or more physical layer (PHY) components, and/or other components, etc.", "For example, such a processor can perform baseband processing operations and can operate in conjunction with a radio, analog front end (AFE), etc.", "The processor can generate such signals, packets, frames, and/or equivalents etc.", "as described herein as well as perform various operations described herein and/or their respective equivalents.", "In some embodiments, such a baseband processing module and/or a processing module (which may be implemented in the same device or separate devices) can perform such processing to generate signals for transmission to another wireless communication device using any number of radios and antennae.", "In some embodiments, such processing is performed cooperatively by a processor in a first device and another processor within a second device.", "In other embodiments, such processing is performed wholly by a processor within one device.", "As may be used herein, the terms “substantially” and “approximately” provides an industry-accepted tolerance for its corresponding term and/or relativity between items.", "Such an industry-accepted tolerance ranges from less than one percent to fifty percent and corresponds to, but is not limited to, component values, integrated circuit process variations, temperature variations, rise and fall times, and/or thermal noise.", "Such relativity between items ranges from a difference of a few percent to magnitude differences.", "As may also be used herein, the term(s) “configured to,” “operably coupled to,” “coupled to,” and/or “coupling” includes direct coupling between items and/or indirect coupling between items via an intervening item (e.g., an item includes, but is not limited to, a component, an element, a circuit, and/or a module) where, for an example of indirect coupling, the intervening item does not modify the information of a signal but may adjust its current level, voltage level, and/or power level.", "As may further be used herein, inferred coupling (i.e., where one element is coupled to another element by inference) includes direct and indirect coupling between two items in the same manner as “coupled to”.", "As may even further be used herein, the term “configured to,” “operable to,” “coupled to,” or “operably coupled to” indicates that an item includes one or more of power connections, input(s), output(s), etc., to perform, when activated, one or more its corresponding functions and may further include inferred coupling to one or more other items.", "As may still further be used herein, the term “associated with,” includes direct and/or indirect coupling of separate items and/or one item being embedded within another item.", "As may be used herein, the term “compares favorably” or equivalent, indicates that a comparison between two or more items, signals, etc., provides a desired relationship.", "For example, when the desired relationship is that signal 1 has a greater magnitude than signal 2, a favorable comparison may be achieved when the magnitude of signal 1 is greater than that of signal 2 or when the magnitude of signal 2 is less than that of signal 1.As may also be used herein, the terms “processing module,” “processing circuit,” “processor,” and/or “processing unit” may be a single processing device or a plurality of processing devices.", "Such a processing device may be a microprocessor, micro-controller, digital signal processor, microcomputer, central processing unit, field programmable gate array, programmable logic device, state machine, logic circuitry, analog circuitry, digital circuitry, and/or any device that manipulates signals (analog and/or digital) based on hard coding of the circuitry and/or operational instructions.", "The processing module, module, processing circuit, and/or processing unit may be, or further include, memory and/or an integrated memory element, which may be a single memory device, a plurality of memory devices, and/or embedded circuitry of another processing module, module, processing circuit, and/or processing unit.", "Such a memory device may be a read-only memory, random access memory, volatile memory, non-volatile memory, static memory, dynamic memory, flash memory, cache memory, and/or any device that stores digital information.", "Note that if the processing module, module, processing circuit, and/or processing unit includes more than one processing device, the processing devices may be centrally located (e.g., directly coupled together via a wired and/or wireless bus structure) or may be distributedly located (e.g., cloud computing via indirect coupling via a local area network and/or a wide area network).", "Further note that if the processing module, module, processing circuit, and/or processing unit implements one or more of its functions via a state machine, analog circuitry, digital circuitry, and/or logic circuitry, the memory and/or memory element storing the corresponding operational instructions may be embedded within, or external to, the circuitry comprising the state machine, analog circuitry, digital circuitry, and/or logic circuitry.", "Still further note that, the memory element may store, and the processing module, module, processing circuit, and/or processing unit executes, hard coded and/or operational instructions corresponding to at least some of the steps and/or functions illustrated in one or more of the Figures.", "Such a memory device or memory element can be included in an article of manufacture.", "One or more embodiments of an invention have been described above with the aid of method steps illustrating the performance of specified functions and relationships thereof.", "The boundaries and sequence of these functional building blocks and method steps have been arbitrarily defined herein for convenience of description.", "Alternate boundaries and sequences can be defined so long as the specified functions and relationships are appropriately performed.", "Any such alternate boundaries or sequences are thus within the scope and spirit of the claims.", "Further, the boundaries of these functional building blocks have been arbitrarily defined for convenience of description.", "Alternate boundaries could be defined as long as the certain significant functions are appropriately performed.", "Similarly, flow diagram blocks may also have been arbitrarily defined herein to illustrate certain significant functionality.", "To the extent used, the flow diagram block boundaries and sequence could have been defined otherwise and still perform the certain significant functionality.", "Such alternate definitions of both functional building blocks and flow diagram blocks and sequences are thus within the scope and spirit of the claimed invention.", "One of average skill in the art will also recognize that the functional building blocks, and other illustrative blocks, modules and components herein, can be implemented as illustrated or by discrete components, application specific integrated circuits, processors executing appropriate software and the like or any combination thereof.", "The one or more embodiments are used herein to illustrate one or more aspects, one or more features, one or more concepts, and/or one or more examples of the invention.", "A physical embodiment of an apparatus, an article of manufacture, a machine, and/or of a process may include one or more of the aspects, features, concepts, examples, etc.", "described with reference to one or more of the embodiments discussed herein.", "Further, from figure to figure, the embodiments may incorporate the same or similarly named functions, steps, modules, etc.", "that may use the same or different reference numbers and, as such, the functions, steps, modules, etc.", "may be the same or similar functions, steps, modules, etc.", "or different ones.", "Unless specifically stated to the contra, signals to, from, and/or between elements in a figure of any of the figures presented herein may be analog or digital, continuous time or discrete time, and single-ended or differential.", "For instance, if a signal path is shown as a single-ended path, it also represents a differential signal path.", "Similarly, if a signal path is shown as a differential path, it also represents a single-ended signal path.", "While one or more particular architectures are described herein, other architectures can likewise be implemented that use one or more data buses not expressly shown, direct connectivity between elements, and/or indirect coupling between other elements as recognized by one of average skill in the art.", "The term “module” is used in the description of one or more of the embodiments.", "A module includes a processing module, a processor, a functional block, hardware, and/or memory that stores operational instructions for performing one or more functions as may be described herein.", "Note that, if the module is implemented via hardware, the hardware may operate independently and/or in conjunction with software and/or firmware.", "As also used herein, a module may contain one or more sub-modules, each of which may be one or more modules.", "While particular combinations of various functions and features of the one or more embodiments have been expressly described herein, other combinations of these features and functions are likewise possible.", "The present disclosure of an invention is not limited by the particular examples disclosed herein and expressly incorporates these other combinations." ] ]
Patent_15872798
[ [ "METHOD OF ESTABLISHING COMMUNICATIONS", "A method of establishing communications with a first device is disclosed.", "The method includes: the first device presenting connection information to a second device; receiving a response from a second device; establishing an association with the second device; transmitting, in response to a determination that the first device and the second device are connected for data, first data to the second device, the first data comprising addressing information for a server; receiving second data from the second device, the second data comprising second information for establishing communications with the first device; and configuring the first device to receive third data from a location remote to the first device using the second information from the second data." ], [ "1.A method of establishing communications with a first device, the method comprising, at the first device: connecting to the second device; in response to a determination that the first device and the second device are connected, transmitting first data to the second device, the first data comprising addressing information for a server; receiving an activation payload from the second device, the activation payload comprising information from the server; and in response to receiving the activation payload from the second device, configuring, using the information from the server, the first device to receive data from a location remote to the first device.", "2.The method of claim 1, wherein: the first device is not able to connect to the server directly, and the second device is able to connect to the server directly.", "3.The method of claim 1, wherein: the first device and the second device have network capabilities, the network capabilities of the first device are more limited than the network capabilities of the second device, and receiving data from a location remote to the first device comprises receiving the data using the network capabilities of the second device.", "4.The method of claim 3, wherein: the network capabilities of the first device include access to a LAN, the network capabilities of the second device include access to one or more of a WAN, the Internet, a Wi-Fi network, and a cellular network, and the network capabilities of the first device do not include access to the one or more of a WAN, the Internet, a Wi-Fi network, and a cellular network.", "5.The method of claim 1, wherein: receiving data from a location remote to the first device comprises receiving the data via one or more of a WAN, the Internet, a Wi-Fi network, and a cellular network, and the network capabilities of the first device do not include access to the one or more of a WAN, the Internet, a Wi-Fi network, and a cellular network.", "6.The method of claim 1, wherein connecting to the second device comprises: pairing with the second device; and establishing a communication channel with the second device.", "7.The method of claim 1, wherein the first data comprises an activation package.", "8.The method of claim 1, wherein the activation payload comprises authentication information.", "9.The method of claim 1, wherein the second device comprises the server.", "10.The method of claim 1, wherein the location remote to the first device corresponds to the location of a cloud server.", "11.The method of claim 1, wherein the location remote to the first device corresponds to the location of the second device.", "12.The method of claim 1, wherein the first device and the second device are connected to a network, and the remote location corresponds to the location of a third device connected to the network.", "13.The method of claim 1, wherein the second device comprises a network gateway.", "14.The method of claim 1, wherein the second device is one of a tablet PC, a smartphone, a cellular phone, a digital media player, an electronic reader, an electronic wearable device, a smart TV, a video game console, a desktop computer, and a laptop computer.", "15.The method of claim 1, wherein receiving data from a location remote to the first device comprises synchronizing data between the first device and the location remote to the first device.", "16.A method of establishing communications with a first device, the method comprising, at a second device: connecting to the first device; in response to a determination that the first device and the second device are connected, receiving first data from the first device, the first data comprising addressing information for a server; connecting to the server using the first data; sending an activation payload to the first device, the activation payload comprising information from the server; and in response to the first device being configured to receive data from a location remote to the first device using the information from the server, sending data to the first device.", "17.The method of claim 16, wherein: the first device is not able to connect to the server directly, and the second device is able to connect to the server directly.", "18.The method of claim 16, wherein: the first device and the second device have network capabilities, the network capabilities of the first device are more limited than the network capabilities of the second device, and the first device receiving data from a location remote to the first device comprises the first device receiving the data using the network capabilities of the second device.", "19.The method of claim 18, wherein: the network capabilities of the first device include access to a LAN, the network capabilities of the second device include access to one or more of a WAN, the Internet, a Wi-Fi network, and a cellular network, and the network capabilities of the first device do not include access to the one or more of a WAN, the Internet, a Wi-Fi network, and a cellular network.", "20.The method of claim 16, wherein: the first device receiving data from a location remote to the first device comprises the first device receiving the data via one or more of a WAN, the Internet, a Wi-Fi network, and a cellular network, and the network capabilities of the first device do not include access to the one or more of a WAN, the Internet, a Wi-Fi network, and a cellular network.", "21.The method of claim 16, wherein connecting to the first device comprises: pairing with the first device; and establishing a communication channel with the first device.", "22.The method of claim 16, wherein the second device comprises the server.", "23.The method of claim 16, wherein the second device comprises a network gateway.", "24.The method of claim 16, wherein the location remote to the first device corresponds to the location of the second device.", "25.A non-transitory computer-readable storage medium storing instructions which, when executed by a processor of a first device, perform a method comprising, at the first device: connecting to the second device; in response to a determination that the first device and the second device are connected, transmitting first data to the second device, the first data comprising addressing information for a server; receiving an activation payload from the second device, the activation payload comprising information from the server; and in response to receiving the activation payload from the second device, configuring, using the information from the server, the first device to receive data from a location remote to the first device.", "26.A non-transitory computer-readable storage medium storing instructions which, when executed by a processor of a second device, perform a method comprising, at the second device: connecting to the first device; in response to a determination that the first device and the second device are connected, receiving first data from the first device, the first data comprising addressing information for a server; connecting to the server using the first data; sending an activation payload to the first device, the activation payload comprising information from the server; and in response to the first device being configured to receive data from a location remote to the first device using the information from the server, sending data to the first device." ], [ "<SOH> BACKGROUND <EOH>A new (or freshly-restored) electronic device usually needs to be activated before it can be used.", "The activation process can typically involve, for example, initializing some basic settings (e.g., date/time, language), security (e.g., username, password), and/or other system and network settings (e.g., phone number, network account) associated with the device.", "Some devices (e.g., smartphones) require a network connection for at least part of the activation process to, for example, register with and receive confirmation from a network server and/or download data from a network.", "However, the activation process can be a challenge for devices restricted by their limited network capabilities and other limitations." ], [ "<SOH> SUMMARY <EOH>This generally relates to activating an electronic device using another electronic device.", "In the embodiments discussed below, the device being activated can be referred to as the first device and the device assisting with the activation of the first device can be referred to as the second device.", "The first device can have limited network capability and/or restricted by its form factor, which can make it difficult for it to perform a self-activation.", "The first device can be paired with the second device.", "A secure channel can be established between the paired devices to allow the first device to pass data to the second device.", "The second device can, in turn, serve as a proxy to make the activation request on behalf of the first device and return the necessary information to the first device to complete the activation process." ], [ "CROSS REFERENCES TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "15/599,088, filed May 18, 2017 and published on Sep. 7, 2017 as U.S. Patent Publication No.", "2017-0257756, which is a continuation of U.S. patent application Ser.", "No.", "14/474,716, filed Sep. 2, 2014 and issued on May 23, 2017 as U.S. Pat.", "No.", "9,661,495, the contents of which are incorporated herein by reference in their entirety for all purposes.", "FIELD This relates generally to methods and systems for activating a device, and more particularly, to using a second device to activate a first device.", "BACKGROUND A new (or freshly-restored) electronic device usually needs to be activated before it can be used.", "The activation process can typically involve, for example, initializing some basic settings (e.g., date/time, language), security (e.g., username, password), and/or other system and network settings (e.g., phone number, network account) associated with the device.", "Some devices (e.g., smartphones) require a network connection for at least part of the activation process to, for example, register with and receive confirmation from a network server and/or download data from a network.", "However, the activation process can be a challenge for devices restricted by their limited network capabilities and other limitations.", "SUMMARY This generally relates to activating an electronic device using another electronic device.", "In the embodiments discussed below, the device being activated can be referred to as the first device and the device assisting with the activation of the first device can be referred to as the second device.", "The first device can have limited network capability and/or restricted by its form factor, which can make it difficult for it to perform a self-activation.", "The first device can be paired with the second device.", "A secure channel can be established between the paired devices to allow the first device to pass data to the second device.", "The second device can, in turn, serve as a proxy to make the activation request on behalf of the first device and return the necessary information to the first device to complete the activation process.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a block diagram illustrating an exemplary network including a first device and a second device, according to an embodiment of the disclosure.", "FIG.", "2 is a flowchart illustrating exemplary steps of activating a first device using a second device as a proxy, according to an embodiment of the disclosure.", "FIG.", "3 is a block diagram illustrating the exemplary modules of a first device, according to an embodiment of the disclosure.", "FIG.", "4 is a block diagram illustrating the exemplary modules of a second device, according to an embodiment of the disclosure.", "FIG.", "5 is a block diagram illustrating the exemplary modules of the network server, according to an embodiment of the disclosure.", "FIG.", "6 illustrates exemplary components of a computing system such as the first device or second device described in the embodiments of the disclosure.", "DETAILED DESCRIPTION In the following description of example embodiments, reference is made to the accompanying drawings in which it is shown by way of illustration specific embodiments that can be practiced.", "It is to be understood that other embodiments can be used and structural changes can be made without departing from the scope of the various embodiments.", "This generally relates to activating an electronic device using another electronic device.", "In the embodiments discussed below, the device being activated can be referred to as the first device and the device assisting with the activation of the first device can be referred to as the second device.", "The first device can have limited network capability and/or restricted by its form factor, which can make it difficult for it to perform a self-activation.", "The first device can be paired with the second device.", "A secure channel can be established between the paired devices to allow the first device to pass data to the second device.", "The second device can, in turn, serve as a proxy to make the activation request on behalf of the first device and return the necessary information to the first device to complete the activation process.", "FIG.", "1 illustrates an exemplary network including the first and second devices 100, 102.The first device 100 can be any electronic device including, but not limited to, a tablet PC, smartphone, cellular phone, digital media player, electronic reader, electronic wearable device, smart TV, video game console, a personal computer (PC), and Mac.", "In some embodiments, the first device 100 can have limited network capability, at least before it is activated.", "For example, the first device 100 may not be able to connect to a cellular or Wi-Fi network and can be limited to having only short distance wireless connections such as a Bluetooth connection.", "The cellular or Wi-Fi capabilities can be unavailable before the activation process is completed.", "Additionally or alternatively, in some embodiments, the first device 100 can be limited by its form factor.", "For example, the first device 100 may not include a virtual or physical keypad that allows a user to enter input such as a Wi-Fi password to establish a Wi-Fi connection.", "As such, the first device 100 may not be able to perform one or more steps of the activation process (e.g., a step that requires a Wi-Fi connection to a network server) on its own.", "In the embodiments described below, the first device 100 can use the second device 102 as its proxy to solve this problem.", "More specifically, the second device 102 can perform a number of steps including, for example, making the activation request to a network server 104 on behalf of the first device 100 and forwarding a confirmation and other information from the network server 104 to the first device 100.The second device 102 can also be any electronic device including, but not limited to, a tablet PC, smartphone, cellular phone, digital media player, electronic reader, electronic wearable device, smart TV, video game console, a personal computer (PC), and Mac.", "Preferably, unlike the first device 100, the second device 102 can be network enabled to connect to, for example, a Wi-Fi or cellular network to communicate with other devices (e.g., network server 104) on the same network.", "Accordingly, the second device 102 can perform its own activation without assistance from another device.", "The second device 102 can additionally have short distance network capability such as Bluetooth that allows it to communicate with the first device 100, as will be detailed below.", "In addition, the second device can include common I/O devices such as a camera, scanner, microphone, and/or display for interfacing with a user and/or another device.", "Referring back to FIG.", "1, the second device can be connected to a network server 104 via a network.", "The network can be any type of computer network including, but not limited to, a local area network (LAN), wide area network (WAN), the Internet, Wi-Fi network, and cellular network.", "The network server 104 can be a cloud server or any other types of computer servers.", "In this embodiment, the first device may not be able to connect to the network server 104 directly when it has not been activated yet.", "FIG.", "2 is a flowchart illustrating the exemplary steps in a method of activating the first device 100, according to an embodiment of the disclosure.", "In this embodiment, the second device 102 can serve as a proxy for the first device 100 by passing the required information back and forth between the first device 100 and the network server 104.As illustrated in FIG.", "2, the activation process can start by powering up the first device (step 201).", "In one embodiment, a welcome screen can be shown followed by one or more screens that allow one or more local setup steps (e.g., selecting a language) to be performed (step 202).", "If the first device is a wearable device, the first device can determine if it is being worn by the user.", "This can be done using one or more sensors (e.g., a touch, proximity sensor, a heart rate sensor, or other biological sensor) built in the first device.", "If it is determined that the first device is not being worn by the user, the first device can display a message asking the user to put on the device to continue the activation process (step 203).", "This step can be optional if the device is already being worn by the user or if the device is not a wearable device.", "In some embodiments, this step can be optional regardless of whether the device is a wearable device or not.", "In this embodiment, because of its limited network capability, the first device may not be able to connect to the network directly.", "Accordingly, the first device can be required to connect to a proxy device such as the second device to continue the activation process.", "For example, the first device can launch an application (e.g., a mobile app) to display a computer-readable code (e.g., a Quick Response (QR) code or bar code) on its display (step 204).", "Specific examples of computer-readable code are disclosed in U.S. patent application Ser.", "No.", "14/339,754, which is hereby incorporated by reference in its entirely.", "In some implementations, the computer readable code is not visible or is difficult to be seen by the human eye.", "The computer-readable code can encode information that can be used in the activation process.", "For example, the computer-readable code can include a device ID for identifying the first device to another device (e.g., the second device).", "In addition, the computer-readable code can include a Bluetooth out-of-band ID (or other similar information) for establishing a communication channel between the first device and the second device.", "In this embodiment, when the computer-readable code is displayed on the first device, the first device can start advertising itself to other devices using, for example, the Bluetooth LE standard advertising protocol (step 205).", "The first device can remain in this state until a response from another device (e.g., the second device) is received.", "Alternatively, the advertising can end after a predetermined period of time.", "To initiate the pairing process, the second device can, for example, scan the computer-readable code displayed on the first device (step 206).", "In one embodiment, a code-scanning app can be launched on the second device.", "The app can turn on the camera on the second device and use the camera to scan the code (e.g., a QR code) displayed on the first device.", "The second device can then use the app to extract the information such as the device ID and the Bluetooth out-of-band key from the code (step 207).", "In other embodiments, different mechanisms can be used to pass the same information from the first device to the second device.", "For example, in one embodiment, the information can be encoded in, for example, an audio clip, that can be captured by a microphone on the second device.", "In another embodiment, a user can tap the two devices together to transfer the information.", "It should be understood that the disclosure is not limited to the mechanisms mentioned in this document and that any suitable means can be used for passing information between the two devices in order to pair the devices.", "In one embodiment, the pairing process can include the first and second devices performing a “handshake” to make sure that the devices are connectible.", "Once it is determined that they can connect, the devices can be connected using, for example, the Bluetooth out-of-band key (e.g., a 16-byte key) extracted from the computer-readable code.", "The key can define the first device as a re-connectable device to the second device and be plugged in on both devices to pair the devices.", "If successful, a Bluetooth secure channel can be brought up (step 208).", "With the secure channel in place, the devices can verify if their identity services (IDS) are running normally (step 209).", "The IDS can include a queue for storing forward messages between the two devices and, thus, be used as a messaging system for facilitating communications between the first and second devices.", "Part of bringing up the IDS can also include checking whether both devices are valid to make sure that not only that there can be a secure connection between them, but that the devices themselves are trusted devices.", "In one embodiment, a device can be deemed a trusted device if it runs the same OS or is on the same platform with respect to the other device.", "After the second device determines that the pairing with the first device is successful and the devices are connected for data, the second device can notify the first device to activate using the IDS channel that has been brought up (step 210).", "This communication can be transmitted via the secure channel within the IDS.", "Although a secure channel within IDS is described as the communication channel between the two devices in this embodiment, it should be understood that other suitable communication channels/services can also be used for performing the same tasks.", "Then, the first device can put together a package of activation data, which can include, for example, the device type, serial number, and unique ID associated with the first device along with a network address such as a uniform resource locator (URL) that identifies the location of a network server.", "The first device can send the package to the second device via the secure channel (step 212).", "After receiving the activation package from the first device, the second device can connect to the network server based on the network address and perform a proxy activation at the network server (step 213).", "The network server can, in turn, send an activation payload back to the second device (step 214).", "The activation payload can include, for example, a confirmation that the first device is a valid device, updates for the first device's regulatory images, and one or more keys for digital rights management (DRM) security.", "The second device can pass this activation payload to the first device via the secured channel within the IDS (step 215).", "Using the information in the activation payload, the first device can complete the activation by, for example, updating its regulatory images, setting up its DRM security, and performing other necessary steps to put itself in an activated state.", "The first device can then notify the second device whether the activation is successful (step 216).", "If the activation is successful, the process is finished.", "If not, the first device can request the second device to display a message to inform the user that the activation has failed and provide an option for the user to try activating the first device again.", "Because IDS can also be used by a messaging service on the devices, they can also leverage a high-level user account (e.g., an Apple ID) associated with the first device to provide additional and/or more advanced features on the first device.", "In one embodiment, the first device can receive a temporary account to identify itself when it is paired with the second device.", "Thereafter, the first device can ask the user to authorize the device using his high-level user account (e.g., Apple ID).", "When authorization is done, additional processes such as software opt-ins and data synchronization (e.g., copying or moving data from the second device and/or another remote location, e.g., a cloud storage, to the first device) can be performed.", "Additionally or alternatively, with the upgraded account, the first device can have direct Wi-Fi access and/or connect to a cloud server by using a push token associated with the account.", "Additionally or alternatively, storage space for the first device can be allocated on the second device or a remote server for backing up and storing data from the first device.", "The secure channel within the IDS can be preserved after the pairing stage to facilitate further communications between the two devices.", "Although embodiment of FIG.", "2 illustrates using one device (e.g., the second device) to activate another device (e.g., the first device), it should be understood that any suitable device within Bluetooth range of the first device can be used to activate the first device.", "FIG.", "3 is a block diagram illustrating the exemplary modules of the first device 100 of FIG.", "1.The first device 100 can include, for example, a prompting module 301, display module 302, advertising module 303, connecting module 304, activation package creating module 305, transmitting module 306, receiving module 307, and notifying module 308.The prompting module 301 can prompt the user to wear the first device.", "Additionally or alternatively, the prompting module 301 can prompt the user to select some of the local settings (e.g., language) of the first device 100.The display module 301 can display a computer-readable code such as a QR code to be used for pairing the first device with another device.", "The advertising module 302 can advertise the first device to other devices in its vicinity (e.g., within the Bluetooth connection radius).", "The connecting module 303 can establish a connection (e.g., a secure channel within IDS) between the first device and the second device.", "The activation package creating module 304 can create an activation package including information that can be used by the second device to perform a proxy activation.", "The transmitting module 305 can transmit the activation package to the second device.", "The receiving module 306 can receive an activation payload from the second device.", "The notifying module 307 can notify the second device whether the activation process is a success.", "It should be understood that some of the modules illustrated in FIG.", "3 can be optional and the first device 100 can include other modules not illustrated in FIG.", "3.FIG.", "4 is a block diagram illustrating the exemplary modules of the second device 102 of FIG.", "1.The second device 102 can include, for example, a scanning module 401, extracting module 402, connecting module 403, notifying module 404, proxy activation module 405, and activation payload forwarding module 406.The scanning module 401 can scan the computer-readable code displayed on a device being activated (e.g., the first device).", "The extracting module 402 can extract information from the scanned computer-readable code.", "The connecting module 403 can establish a communication channel with the first device using information extracted from the scanned computer-readable code.", "The notifying module 404 can notify the first device (e.g., the first device) that a communication channel has been established for transmitting information required to complete the activation of the first device.", "The proxy activating module 405 can perform a proxy activation at a network server in response to a request from the first device.", "The activation payload forward module 406 can forward an activation payload received from the network server to the first device.", "It should be understood that some of the modules illustrated in FIG.", "4 can be optional and the second device 102 can include other modules not illustrated in FIG.", "4.FIG.", "5 is a block diagram illustrating the exemplary modules of the network server 104 of FIG.", "1.The network server 104 can include a receiving module 501 configured to receive an activation request from a device on the network.", "The device can be a device to be activated or a device (e.g., the second device 102) serving as a proxy to the device (e.g., the first device 100) being activated.", "The network server 104 can also include an activation payload generating module 502 that can generate an activation payload to be used in activating a device and a transmitting module 503 that can transmit the activation payload to either the device being activated or the device serving as a proxy to the device being activated.", "Each of the modules of FIGS.", "3-5 can be implemented in software, hardware, or a combination of the two.", "In some embodiments, one or more of the modules of the first device 100, second device 102, and network server 104 can be implemented in software and stored and/or transported within any non-transitory computer-readable storage medium for use by or in connection with an instruction execution system, apparatus, or device, such as a computer-based system, processor-containing system, or other system that can fetch the instructions from the instruction execution system, apparatus, or device and execute the instructions.", "In the context of this document, a “non-transitory computer-readable storage medium” can be any medium that can contain or store the program for use by or in connection with the instruction execution system, apparatus, or device.", "The non-transitory computer readable storage medium can include, but is not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus or device, a portable computer diskette (magnetic), a random access memory (RAM) (magnetic), a read-only memory (ROM) (magnetic), an erasable programmable read-only memory (EPROM) (magnetic), a portable optical disc such a CD, CD-R, CD-RW, DVD, DVD-R, or DVD-RW, or flash memory such as compact flash cards, secured digital cards, USB memory devices, memory sticks, and the like.", "The non-transitory computer readable storage medium can be part of a computing system that can be the first device, second device, or network server in the above-described embodiments.", "FIG.", "6 illustrates exemplary common components of one such computing system.", "As illustrated, the system 600 can include a central processing unit (CPU) 602, I/O components 604 including, but not limited to one or more of display, keypad, touch screen, speaker, and microphone, storage medium 606 such as the ones listed in the last paragraph, and network interface 608, all of which can be connected to each other via a system bus 610.The storage medium 606 can include the modules of FIGS.", "3-5 depending on whether the system is the first device 100, second device 102, or network server 104.Although embodiments have been fully described with reference to the accompanying drawings, it is to be noted that various changes and modifications will become apparent to those skilled in the art.", "Such changes and modifications are to be understood as being included within the scope of the various embodiments as defined by the appended claims." ] ]
Patent_15872801
[ [ "SYSTEM FOR PROVIDING CONTINUAL DRAINAGE IN NEGATIVE PRESSURE WOUND THERAPY", "A system for subatmospheric pressure therapy in connection with healing a wound is provided.", "The system includes a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source.", "The system further includes an exudate conduit in fluid communication with the wound dressing and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum source and a vent conduit in fluid communication with the collection canister and the wound dressing for introducing air into the reservoir to facilitate flow of exudate through the exudate conduit." ], [ "1-3.", "(canceled) 4.A negative pressure wound therapy system comprising: a wound dressing comprising a cover layer configured to be placed over a wound and form a substantially fluid tight seal around the wound; a port configured to be positioned over and attached to the cover layer in order to be in fluid communication with the wound, the port comprising: a wound-facing surface configured to be positioned over the cover layer; and one or more fluid flow paths configured to introduce fluid under the cover layer, wherein at least one fluid flow path extends beyond the wound-facing surface of the port; and an elongate conduit configured to fluidically connect the port to a negative pressure source to provide negative pressure to the wound, wherein the elongate conduit is independent of the one or more fluid flow paths.", "5.The system according to claim 4, wherein the at least one fluid flow path is configured to extend into the wound when the port is attached to the cover layer.", "6.The system according to claim 4, wherein at least one tube fluid flow path includes a filter at an end opposite from an end that extends beyond the wound-facing surface of the port.", "7.The system according to claim 4, wherein at least one fluid flow path includes a puncturing tip at an end that extends beyond the wound-facing surface of the port.", "8.The system according to claim 4, wherein at least one fluid flow path comprises a valve operable to control the flow of fluid into the wound.", "9.The system according to claim 8, wherein the valve is a needle valve.", "10.The system according to claim 4, wherein each of the one or more fluid flow paths extends beyond the wound-facing surface of the port.", "11.The system according to claim 10, wherein the port is circular, and wherein the one or more fluid flow paths are placed around an interior circular portion of the port.", "12.The system according to claim 4, wherein the wound dressing further comprises a wound packing material configured to be disposed in the wound, and wherein the at least one fluid flow path is configured to extend into the wound packing material when the port is attached to the cover layer.", "13.The system according to claim 4, wherein the at least one fluid flow path is configured to introduce atmospheric air under the cover layer.", "14.The system according to claim 4, wherein the one or more fluid flow paths comprise tubes.", "15.The system according to claim 4, wherein the port comprises a central opening configured to be in fluid communication with the elongate conduit.", "16.A method of providing negative pressure wound therapy, the method comprising: positioning a wound dressing comprising a cover layer over a wound to form a substantially fluid tight seal around the wound; positioning over and attaching to the cover layer a wound-facing surface of a port, wherein the port comprises one or more fluid flow paths configured to introduce fluid under the cover layer, and wherein at least one fluid flow path extends beyond the wound-facing surface of the port and includes an end positioned at least partially under the cover layer and in the wound; and connecting a negative pressure source to the port via an elongate conduit, wherein the elongate conduit is independent of the one or more fluid flow paths.", "17.The method according to claim 16, wherein each of the one or more fluid flow paths extends beyond the wound-facing surface of the port.", "18.The method according to claim 16, further comprising positioning wound packing material in the wound, and wherein the end of the at least one fluid flow path at least partially extends into the wound packing material.", "19.The method according to claim 16, further comprising introducing fluid into the wound through the at least one fluid flow path.", "20.The method according to claim 19, further comprising introducing atmospheric air through the at least one fluid flow path." ], [ "<SOH> BACKGROUND <EOH>1.Technical Field The present disclosure relates generally to treating a wound with negative or reduced pressure.", "In particular, the disclosure relates to a system for providing continual drainage of fluids from a wound site to a collection canister.", "2.Background of Related Art Various techniques to promote healing of a wound involve providing suction to the wound.", "For example, a vacuum source may serve to carry wound exudates away from the wound, which may otherwise harbor bacteria that inhibit the body's natural healing process.", "One particular technique for promoting the body's natural healing process may be described as negative pressure wound therapy (NPWT).", "This technique involves the application of a reduced pressure, e.g.", "sub-atmospheric, to a localized reservoir over a wound.", "Sub-atmospheric pressure has been found to assist in closing the wound by promoting blood flow to the area, thereby stimulating the formation of granulation tissue and the migration of healthy tissue over the wound.", "This technique has proven effective for chronic or non-healing wounds, but has also been used for other purposes such as post-operative wound care.", "The general NPWT protocol provides for covering the wound with a flexible cover layer such as a polymeric film, for example, to establish a vacuum reservoir over the wound where a reduced pressure may be applied by individual or cyclic evacuation procedures.", "To allow the reduced pressure to be maintained over time, the cover layer may include an adhesive periphery that forms a substantially fluid tight seal with the healthy skin surrounding the wound.", "Although some procedures may employ a micro-pump contained within the vacuum reservoir, most NPWT treatments apply a reduced pressure using an external vacuum source.", "Fluid communication must therefore be established between the reservoir and the vacuum source.", "To this end, a fluid port is coupled to the cover layer to provide an interface for an exudate conduit extending from the external vacuum source.", "Fluid being drained from the reservoir through the exudate conduit tends to stagnate with slow fluid buildup.", "This stagnation results in interrupted and/or incomplete fluid drainage.", "Accordingly, it would be beneficial to have a negative pressure wound therapy system that included a controlled or fixed “leak” to provide for continuous and/or complete fluid drainage." ], [ "<SOH> SUMMARY <EOH>A system for subatmospheric pressure therapy in connection with healing a wound is provided.", "The system includes a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source.", "The system further includes an exudate conduit in fluid communication with the wound dressing and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum source and a vent conduit in fluid communication with the collection canister and the wound dressing for introducing air into the reservoir to facilitate flow of exudate through the exudate conduit.", "The vent conduit may define an internal dimension less than a corresponding internal dimension of the exudate conduit.", "The exudate conduit and the vent conduit may include independent tube segments, or instead may include integral tube segments.", "A filter may be in fluid communication with the vent conduit.", "The filter includes a hydrophobic material.", "The filter may instead or additionally include a bacterial filter.", "Also provided is a system for subatmospheric pressure therapy in connection with healing a wound including a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source.", "The system further includes an exudate conduit in fluid communication with the wound dressing and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum source and a vent mounted to the wound dressing, the vent being selectively movable between a closed position and an open position, the vent permitting ingress of air within the reservoir when in the open position.", "The vent may include a flap mounted to the wound dressing cover, the flap being movable between the closed position and the open position.", "The flap may be releasably securable in the closed position with an adhesive.", "A filter membrane may be mounted adjacent the flap.", "The filter membrane may include a hydrophobic material.", "The filter membrane may instead or additionally include a bacterial filter.", "Additionally, provided is a system for subatmospheric pressure therapy in connection with healing a wound including a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source.", "The system further includes an exudate conduit in fluid communication with the wound dressing and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum source and a filtered air vent mounted to the wound dressing cover, the filtered air vent adapted to permit ingress of air within the reservoir to facilitate flow of exudate through the exudate conduit.", "Additionally, provided is a system for subatmospheric pressure therapy in connection with healing a wound including a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source.", "The system also includes a wound port operatively connected to the wound dressing in fluid communication with the reservoir.", "The wound port includes a vacuum port and at least one tube piercing through the wound port into the reservoir, the tube being operable to allow ambient air into the reservoir.", "The system further includes an exudate conduit in fluid communication with the wound port and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum.", "Additionally, provided is a system for subatmospheric pressure therapy in connection with healing a wound including a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source.", "The system also includes a wound port operatively connected to the wound dressing in fluid communication with the reservoir.", "The wound port includes a vacuum port and a plurality of holes arranged circumferentially around the wound port, the plurality of holes being operable to allow ambient air into the reservoir.", "The system further includes an exudate conduit in fluid communication with the wound port and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum.", "Additionally, provided is a system for subatmospheric pressure therapy in connection with healing a wound including a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source.", "The system also includes a wound port operatively connected to the wound dressing in fluid communication with the reservoir.", "The wound port includes a vacuum port and an orifice being operable to allow ambient air into the reservoir.", "The system further includes an exudate conduit in fluid communication with the wound port and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum.", "Additionally, provided is a system for subatmospheric pressure therapy in connection with healing a wound including a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source.", "The system also includes a wound port operatively connected to the wound dressing in fluid communication with the reservoir.", "The system further includes an exudate conduit in fluid communication with the wound port and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum.", "The exudate conduit has a first conduit for providing a pathway for the exudate between the reservoir and the collection canister and a second conduit in fluid communication with ambient atmosphere and the wound dressing for introducing air into the reservoir to facilitate flow of exudate through the exudate conduit." ], [ "BACKGROUND 1.Technical Field The present disclosure relates generally to treating a wound with negative or reduced pressure.", "In particular, the disclosure relates to a system for providing continual drainage of fluids from a wound site to a collection canister.", "2.Background of Related Art Various techniques to promote healing of a wound involve providing suction to the wound.", "For example, a vacuum source may serve to carry wound exudates away from the wound, which may otherwise harbor bacteria that inhibit the body's natural healing process.", "One particular technique for promoting the body's natural healing process may be described as negative pressure wound therapy (NPWT).", "This technique involves the application of a reduced pressure, e.g.", "sub-atmospheric, to a localized reservoir over a wound.", "Sub-atmospheric pressure has been found to assist in closing the wound by promoting blood flow to the area, thereby stimulating the formation of granulation tissue and the migration of healthy tissue over the wound.", "This technique has proven effective for chronic or non-healing wounds, but has also been used for other purposes such as post-operative wound care.", "The general NPWT protocol provides for covering the wound with a flexible cover layer such as a polymeric film, for example, to establish a vacuum reservoir over the wound where a reduced pressure may be applied by individual or cyclic evacuation procedures.", "To allow the reduced pressure to be maintained over time, the cover layer may include an adhesive periphery that forms a substantially fluid tight seal with the healthy skin surrounding the wound.", "Although some procedures may employ a micro-pump contained within the vacuum reservoir, most NPWT treatments apply a reduced pressure using an external vacuum source.", "Fluid communication must therefore be established between the reservoir and the vacuum source.", "To this end, a fluid port is coupled to the cover layer to provide an interface for an exudate conduit extending from the external vacuum source.", "Fluid being drained from the reservoir through the exudate conduit tends to stagnate with slow fluid buildup.", "This stagnation results in interrupted and/or incomplete fluid drainage.", "Accordingly, it would be beneficial to have a negative pressure wound therapy system that included a controlled or fixed “leak” to provide for continuous and/or complete fluid drainage.", "SUMMARY A system for subatmospheric pressure therapy in connection with healing a wound is provided.", "The system includes a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source.", "The system further includes an exudate conduit in fluid communication with the wound dressing and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum source and a vent conduit in fluid communication with the collection canister and the wound dressing for introducing air into the reservoir to facilitate flow of exudate through the exudate conduit.", "The vent conduit may define an internal dimension less than a corresponding internal dimension of the exudate conduit.", "The exudate conduit and the vent conduit may include independent tube segments, or instead may include integral tube segments.", "A filter may be in fluid communication with the vent conduit.", "The filter includes a hydrophobic material.", "The filter may instead or additionally include a bacterial filter.", "Also provided is a system for subatmospheric pressure therapy in connection with healing a wound including a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source.", "The system further includes an exudate conduit in fluid communication with the wound dressing and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum source and a vent mounted to the wound dressing, the vent being selectively movable between a closed position and an open position, the vent permitting ingress of air within the reservoir when in the open position.", "The vent may include a flap mounted to the wound dressing cover, the flap being movable between the closed position and the open position.", "The flap may be releasably securable in the closed position with an adhesive.", "A filter membrane may be mounted adjacent the flap.", "The filter membrane may include a hydrophobic material.", "The filter membrane may instead or additionally include a bacterial filter.", "Additionally, provided is a system for subatmospheric pressure therapy in connection with healing a wound including a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source.", "The system further includes an exudate conduit in fluid communication with the wound dressing and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum source and a filtered air vent mounted to the wound dressing cover, the filtered air vent adapted to permit ingress of air within the reservoir to facilitate flow of exudate through the exudate conduit.", "Additionally, provided is a system for subatmospheric pressure therapy in connection with healing a wound including a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source.", "The system also includes a wound port operatively connected to the wound dressing in fluid communication with the reservoir.", "The wound port includes a vacuum port and at least one tube piercing through the wound port into the reservoir, the tube being operable to allow ambient air into the reservoir.", "The system further includes an exudate conduit in fluid communication with the wound port and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum.", "Additionally, provided is a system for subatmospheric pressure therapy in connection with healing a wound including a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source.", "The system also includes a wound port operatively connected to the wound dressing in fluid communication with the reservoir.", "The wound port includes a vacuum port and a plurality of holes arranged circumferentially around the wound port, the plurality of holes being operable to allow ambient air into the reservoir.", "The system further includes an exudate conduit in fluid communication with the wound port and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum.", "Additionally, provided is a system for subatmospheric pressure therapy in connection with healing a wound including a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source.", "The system also includes a wound port operatively connected to the wound dressing in fluid communication with the reservoir.", "The wound port includes a vacuum port and an orifice being operable to allow ambient air into the reservoir.", "The system further includes an exudate conduit in fluid communication with the wound port and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum.", "Additionally, provided is a system for subatmospheric pressure therapy in connection with healing a wound including a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source.", "The system also includes a wound port operatively connected to the wound dressing in fluid communication with the reservoir.", "The system further includes an exudate conduit in fluid communication with the wound port and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum.", "The exudate conduit has a first conduit for providing a pathway for the exudate between the reservoir and the collection canister and a second conduit in fluid communication with ambient atmosphere and the wound dressing for introducing air into the reservoir to facilitate flow of exudate through the exudate conduit.", "BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the present disclosure and, together with the detailed description of the embodiments given below, serve to explain the principles of the disclosure.", "FIG.", "1 depicts an embodiment of a NPWT system in accordance with the present disclosure; FIG.", "2 depicts an embodiment of an NPWT treatment apparatus including a vent conduit; FIG.", "3A is a partial cross sectional view of the conduits of the NPWT treatment apparatus of FIGS.", "1 and 2 connected in an alternate configuration; FIG.", "3B is a partial cross sectional view of an alternative embodiment of the fluid port of FIGS.", "1 and 2; FIG.", "4 is a cross sectional view of an alternative embodiment of the wound dressing in accordance with the present disclosure; FIGS.", "5A and 5B depict alternative embodiments of the wound dressing in accordance with the present disclosure; FIGS.", "6A and 6B depict alternative embodiments of the wound dressing in accordance with the present disclosure; FIGS.", "7A and 7B depict alternative embodiments of the wound dressing in accordance with the present disclosure; FIGS.", "8A and 8B depict alternative embodiments of the wound dressing in accordance with the present disclosure; FIG.", "9 depicts an alternative embodiment of the wound port in accordance with the present disclosure; FIGS.", "10A and 10B depict alternative embodiments of the wound port in accordance with the present disclosure; and FIGS.", "11A-11D depict alternative embodiments of the wound port in accordance with the present disclosure.", "DETAILED DESCRIPTION OF EMBODIMENTS Various embodiments of the present disclosure provide negative pressure wound therapy systems (or apparatus) including a collection canister having a chamber to collect wound fluids.", "Embodiments of the presently disclosed negative pressure wound therapy systems are generally suitable for use in applying negative pressure to a wound to facilitate healing of the wound in accordance with various treatment modalities.", "Embodiments of the presently disclosed negative pressure wound therapy systems are entirely portable and may be worn or carried by the user such that the user may be completely ambulatory during the therapy period.", "Embodiments of the presently disclosed negative pressure wound therapy apparatus and components thereof may be entirely reusable or may be entirely disposable after a predetermined period of use or may be individually disposable whereby some of the components are reused for a subsequent therapy application.", "Hereinafter, embodiments of the presently disclosed negative pressure wound therapy systems and embodiments of the presently disclosed sensors for use in negative pressure wound therapy systems will be described with reference to the accompanying drawings.", "Like reference numerals may refer to similar or identical elements throughout the description of the figures.", "As used herein, “wound exudate”, or, simply, “exudate”, generally refers to any fluid output from a wound, e.g., blood, serum, and/or pus, etc.", "As used herein, “fluid” generally refers to a liquid, a gas or both.", "Referring to FIG.", "1, a NPWT apparatus according to an embodiment of the present disclosure is depicted generally as 10 for use on a wound bed “w” surrounded by healthy skin “s”.", "Negative pressure wound therapy apparatus 10 includes a wound dressing 12 positioned relative to the wound bed “w” to define a vacuum chamber 14 about the wound bed “w” to maintain negative pressure at the wound area.", "Wound dressing 12 includes a contact layer 18, a wound filler 20 and a wound cover 24.Contact layer 18 is intended for placement within the wound bed “w” and may be relatively non-supportive or flexible to substantially conform to the topography of the wound bed “w”.", "A variety of materials may be used for the contact layer 18.Contact layer 18 selection may depend on various factors such as the patient's condition, the condition of the periwound skin, the amount of exudate and/or the condition of the wound bed “w”.", "Contact layer 18 may be formed from perforated film material.", "The porous characteristic of the contact layer 18 permits exudate to pass from the wound bed “w” through the contact layer 18.Passage of wound exudate through the contact layer 18 may be substantially unidirectional such that exudate does not tend to flow back into the wound bed “w”.", "Unidirectional flow may be encouraged by directional apertures, e.g., apertures positioned at peaks of undulations or cone-shaped formations protruding from the contact layer 18.Unidirectional flow may also be encouraged by laminating the contact layer 18 with materials having absorption properties differing from those of the contact layer 18, or by selection of materials that promote directional flow.", "A non-adherent material may be selected for forming the contact layer 18 such that the contact layer 18 does not tend to cling to the wound bed “w” or surrounding tissue when it is removed.", "One example of a material that may be suitable for use as a contact layer 18 is commercially available under the trademark XEROFLOW® offered by Tyco Healthcare Group LP (d/b/a Covidien).", "Another example of a material that may be suitable for use as the contact layer 18 is the commercially available CURITY® non-adherent dressing offered by Tyco Healthcare Group LP (d/b/a Covidien).", "Wound filler 20 is positioned in the wound bed “w” over the contact layer 18 and is intended to transfer wound exudate.", "Wound filler 20 is conformable to assume the shape of any wound bed “w” and may be packed up to any level, e.g., up to the level of healthy skin “s” or to overfill the wound such that wound filler 20 protrudes over healthy skin “s”.", "Wound filler 20 may be treated with agents such as polyhexamethylene biguanide (PHMB) to decrease the incidence of infection and/or other medicaments to promote wound healing.", "A variety of materials may be used for the wound filler 20.An example of a material that may be suitable for use as the wound filler 20 is the antimicrobial dressing commercially available under the trademark KERLIX™ AMD™ offered by Tyco Healthcare Group LP (d/b/a Covidien).", "Cover layer 24 may be formed of a flexible membrane, e.g., a polymeric or elastomeric film, which may include a biocompatible adhesive on at least a portion of the cover layer 24, e.g., at the periphery 26 of the cover layer 24.Alternately, the cover layer 24 may be a substantially rigid member.", "Cover layer 24 may be positioned over the wound bed “w” such that a substantially continuous band of a biocompatible adhesive at the periphery 26 of the cover layer 24 forms a substantially fluid-tight seal with the surrounding skin “s”.", "An example of a material that may be suitable for use as the cover layer 24 is commercially available under the trademark CURAFORM ISLAND® offered by Tyco Healthcare Group LP (d/b/a Covidien).", "Cover layer 24 may act as both a microbial barrier and a fluid barrier to prevent contaminants from entering the wound bed “w” and to help maintain the integrity thereof In one embodiment, the cover layer 24 is formed from a moisture vapor permeable membrane, e.g., to promote the exchange of oxygen and moisture between the wound bed “w” and the atmosphere.", "An example of a membrane that may provide a suitable moisture vapor transmission rate (MVTR) is a transparent membrane commercially available under the trade name POLYSKIN® II offered by Tyco Healthcare Group LP (d/b/a Covidien).", "A transparent membrane may help to permit a visual assessment of wound conditions to be made without requiring removal of the cover layer 24.Wound dressing 12 may include a vacuum port 30 having a flange 34 to facilitate connection of the vacuum chamber 14 to a vacuum system.", "Vacuum port 30 may be configured as a rigid or flexible, low-profile component and may be adapted to receive a conduit 36 in a releasable and fluid-tight manner.", "An adhesive on at least a portion of the underside of the flange 34 may be used to provide a mechanism for affixing the vacuum port 30 to the cover layer 24.The relative positions, size and/or shape of the vacuum port 30 and the flange 34 may be varied from an embodiment depicted in FIG.", "1.For example, the flange 34 may be positioned within the vacuum chamber 14 such that an adhesive on at least a portion of an upper side surface of the flange 34 affixes the vacuum port 30 to the cover layer 24.A hollow interior portion of the vacuum port 30 provides fluid communication between the conduit 36 and the vacuum chamber 14.Conduit 36 extends from the vacuum port 30 to provide fluid communication between the vacuum chamber 14 and the vacuum source 40.Alternately, the vacuum port 30 may not be included in the dressing 12 if other provisions are made for providing fluid communication with the conduit 36.Any suitable conduit may be used for the conduit 36, including conduit fabricated from flexible elastomeric or polymeric materials.", "In the negative pressure wound therapy apparatus 10 illustrated in FIG.", "1, the conduit 36 includes a first conduit section 36A, a second conduit section 36B, a third conduit section 36C and a fourth conduit section 36D.", "The first conduit section 36A extends from the vacuum port 30 and is coupled via a fluid line coupling 100 to the second conduit section 36B, which extends to the collection canister 38.The third conduit section 36C extends from the collection canister 38 and is coupled via another fluid line coupling 100 to the fourth conduit section 36D, which extends to the vacuum source 40.The shape, size and/or number of conduit sections of the conduit 36 may be varied from the first, second, third and fourth conduit sections 36A, 36B, 36C and 36D depicted in FIG.", "1.The first, second, third and fourth conduit sections 36A, 36B, 36C and 36D of the conduit 36 may be connected to components of the apparatus 10 by conventional air-tight means, such as, for example, friction fit, bayonet coupling, or barbed connectors.", "The connections may be made permanent.", "Alternately, a quick-disconnect or other releasable connection means may be used to provide some adjustment flexibility to the apparatus 10.Collection canister 38 may be formed of any type of container that is suitable for containing wound fluids.", "For example, a semi-rigid plastic bottle may be used for the collection canister 38.A flexible polymeric pouch or other hollow container body may be used for the collection canister 38.Collection canister 38 may contain an absorbent material to consolidate or contain the wound fluids or debris.", "For example, super absorbent polymers (SAP), silica gel, sodium polyacrylate, potassium polyacrylamide or related compounds may be provided within collection canister 38.At least a portion of canister 38 may be transparent or semi-transparent, e.g., to permit a visual assessment of the wound exudate to assist in evaluating the color, quality and/or quantity of exudate.", "A transparent or semi-transparent portion of the collection canister 38 may permit a visual assessment to assist in determining the remaining capacity or open volume of the canister and/or may assist in determining whether to replace the collection canister 38.The collection canister 38 is in fluid communication with the wound dressing 12 via the first and second conduit sections 36A, 36B.", "The third and fourth conduit sections 36C, 36D connect the collection canister 38 to the vacuum source 40 that generates or otherwise provides a negative pressure to the collection canister 38.Vacuum source 40 may include a peristaltic pump, a diaphragmatic pump or other suitable mechanism.", "Vacuum source 40 may be a miniature pump or micropump that may be biocompatible and adapted to maintain or draw adequate and therapeutic vacuum levels.", "The vacuum level of subatmospheric pressure achieved may be in the range of about 20 mmHg to about 500 mmHg In embodiments, the vacuum level may be about 75 mmHg to about 125 mmHg, or about 40 mmHg to about 80 mmHg One example of a peristaltic pump that may be used as the vacuum source 40 is the commercially available Kangaroo PET Eternal Feeding Pump offered by Tyco Healthcare Group LP (d/b/a Covidien).", "Vacuum source 40 may be actuated by an actuator (not shown) which may be any means known by those skilled in the art, including, for example, alternating current (AC) motors, direct current (DC) motors, voice coil actuators, solenoids, and the like.", "The actuator may be incorporated within the vacuum source 40.In embodiments, the negative pressure wound therapy apparatus 10 includes one or more fluid line couplings 100 that allow for selectable coupling and decoupling of conduit sections.", "For example, a fluid line coupling 100 may be used to maintain fluid communication between the first and second conduit sections 36A, 36B when engaged, and may interrupt fluid flow between the first and second conduit sections 36A, 36B when disengaged.", "Thus, fluid line coupling 100 may facilitate the connection, disconnection or maintenance of components of the negative pressure wound therapy apparatus 10, including the replacement of the collection canister 38.Additional or alternate placement of one or more fluid line couplings 100 at any location in line with the conduit 36 may facilitate other procedures.", "For example, the placement of a fluid line coupling 100 between the third and fourth conduit sections 36C, 36D, as depicted in FIG.", "1, may facilitate servicing of the vacuum source 40.Referring to FIG.", "2, an NPWT apparatus similar to the NPWT apparatus of FIG.", "1 is depicted generally as 10 for use on a wound “w” surrounded by healthy skin “s.” The NPWT apparatus 10 of FIG.", "2 includes a vent conduit 37 that extends from between contact layer 18 and cover layer 22 of wound dressing 12 to collection canister 38.Vent conduit 37 may be integral formed with wound dressing 12.Alternatively, vent conduit 37 may be inserted between contact layer 18 and cover layer 22 by a clinician during application of the wound dressing 12, or may have been previously inserted therebetween prior to application.", "Vent conduit 37 may be releasably connected to the collection canister 38 by conventional air-tight means such as friction fit, bayonet coupling, or barbed connectors.", "Vent conduit 37 is configured to provide a low flow of air from the reservoir 14 to the collection canister 38.Vent conduit 37 includes a smaller diameter than exudate conduit 36 and may be formed of any suitable conduit including those fabricated from flexible elastomeric or polymeric materials.", "An air filter 39 positioned along the air flow path filters the air flowing from collection canister 38 to remove any impurities, including bacteria and other infectious material.", "Filter 39 may include a hydrophobic material to prevent wetting.", "In operation, wound dressing 12 is placed adjacent a wound “w” with the vent conduit 37 extending from between the contact layer 18 and the cover layer 22.If the vent conduit 37 is not integral formed with the wound dressing 12, the clinician may be required to position the vent conduit 37 between the layers during application of the wound dressing 12.Vacuum source 50 is then activated to produce a sub-atmospheric pressure in the reservoir 14 of the wound dressing 12.Fluid from the reservoir 14 is drawn through aperture 24 in cover layer 22, into fluid port 30 and along exudate conduit 36 to be deposited in collection canister 40.As fluid and other exudates are drawn through exudate conduit 36, filtered air is received within the reservoir 14 of the wound dressing 12 through the vent conduit 37.The low flow filtered air flowing from the collection canister 38 through the vent conduit 37, in combination with the high flow drainage occurring through exudate conduit 36, creates a sump action between the reservoir 14 and the collection canister 40.This sump action ensures continuous flow through exudate conduit 36, thereby preventing fluid stagnation and its complications.", "Because of capillary action, fluid from reservoir 14 only flows through the larger diameter exudate conduit 36.With reference now to FIG.", "3A, in an alternative embodiment of the present disclosure, a wound dressing 112 is substantially similar to wound dressing 12 described hereinabove, and will only be described as relates to the differences therebetween.", "Wound dressing 112 includes a cover layer 122 having a first or fluid aperture 124 and a second or vent aperture 125.A fluid port 130 is in fluid communication with fluid aperture 124 and is configured for operable engagement with exudate conduit 136.A vent port 131 is in fluid communication with vent aperture 125 and is configured for operable engagement with vent conduit 137.Fluid and vent ports 130, 131 may be affixed to cover layer 122 in any suitable manner.", "Each of fluid and vent port 130, 131 are in fluid communication with collection canister 38 (FIGS.", "1 and 2).", "Wound dressing 112 operates in substantially the same manner as wound dressing 12.When connected to collection canister 40 and the vacuum source 50 is activated, the sub-atmospheric pressure produced by the vacuum source 50 creates a suction that draws fluid from the reservoir 114.Vent conduit 137 provides the reservoir 114 with a low flow of filtered air to ensure continuous fluid flow through the exudate conduit 136.Turning now to FIG.", "3B, in another embodiment, wound dressing 212 is substantially similar to the wound dressings 12, 112 described hereinabove.", "Wound dressing 212 includes a cover layer 222 having a first and second aperture 224, 225.Positioned adjacent first and second apertures 224, 225 is a fluid/vent port 230.Port 230 is configured to fluidly communicate first aperture 224 of wound dressing 212 with collection canister 38 (FIGS.", "1 and 2) via exudate conduit 236.Port 230 is further configured to fluidly communicate second aperture 225 of wound dressing 212 with collection canister 40 via vent conduit 237.As discussed above, the difference in size between exudate conduit 236 and vent conduit 237 results in capillary action that causes fluid to flow only through the larger exudate conduit 36.With reference now to FIG.", "4, in yet another embodiment, a wound dressing 312 similar to those described above including a vent assembly 340 formed in a cover layer 322.Vent assembly 340 includes a filter member 342 and a flap or cover member 344.Filter member 342 may be integrally formed with, or otherwise affixed to, the cover layer 322.In one embodiment, filter member 342 is secured to the cover layer 322 with an adhesive.", "Filter member 342 is configured to provide reservoir 314 of wound dressing 312 with filtered air.", "To prevent wetting, the filter member 342 may be hydrophobic.", "Filter member 342 may be sized depending on the desired flow therethrough.", "A larger filter member 342 would provide a greater amount of airflow; however, if the filter member 342 is too large, it may reduce the effectiveness of the NWPT.", "Flap 344 may be integrally formed with cover layer 322.Alternatively, flap 344 may be releasably secured over filter member 342.Flap 344 may be attached to or separable from cover member 322.Flap 344 may be configured to selectively partially or completely uncover filter member 342.In this manner, a clinician may affect the flow of air into the reservoir 314.Although shown including flap 344, it is envisioned that wound dressing 312 may be provided with filter member 342 exposed.", "In use, wound dressing 312 is applied to a wound “w” in a conventional manner.", "Activation of the vacuum source 40 (FIGS.", "1 and 2) initiates drainage from reservoir 314 of wound dressing 312.At any time prior to or during the drainage process, flap 344 may be partially or complete pulled back to expose filter member 342.As described above, the more of filter member 342 that is exposed, the greater the possible airflow into reservoir 14.The airflow provided to reservoir 14 through filter member 342 acts in a manner similar to the sump action described above.", "In this manner, vent assembly 340 permits continuous fluid flow through exudate conduit 336, thereby preventing fluid stagnation and its complications.", "With reference to FIGS.", "5A and 5B, in yet another embodiment, a wound port 500 is shown.", "Wound port 500 is suitable for use with the above described wound dressings.", "Wound port 500 has a plastic cover 510 which includes a vacuum port 512.In addition to the vacuum port 512, the plastic cover 510 has tube 520.Tube 520 may be made of a small-bore stainless steel or rigid plastic.", "Tube 520 is used to provide a controlled or fixed leak by admitting air into the wound dressing.", "Tube 520 can be arranged to allow the insertion of tube 520 into the wound port 500 so that depth adjustment and placement within the wound packing material is possible as indicated by the arrows in FIGS.", "5A and 5B.", "As such, air can be injected into the wound packing material to direct movement of excess exudate toward the vacuum port and out of the wound.", "Tube 520 may have a valve (not shown) to adjust the flow rate of air into the wound bed.", "The valve may be a small needle valve that can be attached to the tube 520 to allow for infinite adjustment of air flow into the wound dressing.", "The end of tube 520 that may be exposed to ambient atmosphere or to a source of air may include a filter 522.Filter 522 may be a q-tip like air filter to prevent clogging of the tube and also prevent dirt and other contaminants from entering the wound site.", "Alternatively, filter 522 may include a charcoal filter to prevent odor, a hydrophobic filter, or any sintered or porous material.", "The tip of tube 520 that is inserted into the wound packing material may be equipped with a puncturing tip 524 to allow for easier insertion into the wound packing material.", "With reference to FIGS.", "6A and 6B, in yet another embodiment, a wound port 600 is shown.", "As shown in FIG.", "6A, wound port 600 has tube 610 in separate locations around a circumference of the wound port 600.Each tube may include a punctured tip or a filter as described above.", "As shown in FIG.", "6B, the distance “a” between tube 610 and tube 612 may be one distance and the distance “b” between tube 610 and 614 may be a distance different the distance “a”.", "On the other hand, the difference between each tube may be similar as in the distance “c” between tube 620 and 622 and tube 620 and 624.Although FIGS.", "6A and 6B show a specific number of tubes, any number of tubes may be arranged outside a circumference of the wound port 600.With reference to FIGS.", "7A and 7B, in yet another embodiment, a wound port 700 is shown having a tube 710 which is similar to the tubes described above.", "Tube 710 may be slightly larger in diameter to allow for fluids to enter the wound site.", "The fluids may include a solution to flush the wound such as saline or it may be an anesthetic to anesthetize the wound area.", "Tube 710 may be fitted with valve 712 to open and close the pathway into the wound site.", "Additionally, the end of tube 710 may be fitted with a luer connector 714 to create a fluid tight connection with additional tubing, syringes, or any other conduits.", "Alternatively, instead of a valve, a plug (not shown) could be used to close the luer connector.", "With reference to FIG.", "7B, a hypodermic needle 716 may be inserted into tube 710.Hypodermic needle 716 could be used to deliver a solution to a specific area of the wound or it could be used to obtain a sample of blood, exudate or tissue from the wound site.", "With reference to FIGS.", "8A and 8B, in yet another embodiment, a wound port 800 is shown.", "Instead of using tubes as described above to allow a controlled or fixed leak, a number of small holes arranged in a circumference around the wound port 800 may be provided.", "The holes may take the form of a simple puncture 810 of a given size as shown in FIG.", "8A.", "Alternatively, the holes 822 may be formed in a plate 820 that is radio frequency (RF) welded to the wound port 800.With reference to FIG.", "9, in yet another embodiment, a cross section of wound port 900 is shown.", "Wound port 900 is operatively connected to wound dressing 910 and includes a flange 912.Flange 912 may have a circular or any polygonal shape.", "A body 914 is connected to the flange 912 which is fluidly connected to conduit 916.Conduit 916 leads directly or indirectly to the collection canister.", "Body 914 has as small orifice 920 used to provide a controlled leak into the wound site.", "The diameter of the orifice 920 and the pressure difference between the outside of the wound port 900 and the inside of the wound port 90 create a controllable air leak into the wound port 900 via the orifice.", "The small orifice 920 can be created in various ways.", "The orifice 920 can be integral to the port design, such as a molded in feature.", "It can be created via post molding micro-piercing into the port using a needle or syringe.", "Alternatively, assembly or insertion of a small tube that allows for communication of air from outside the wound port 900 to inside the wound port 900 can be used to create the orifice 920.With reference to FIGS.", "10A and 10B, in yet another embodiment, a wound port 1000 is shown.", "Wound port 1000 is operatively connected to wound dressing 1010 and includes a flange 1012.Flange 1012 may have a circular or any polygonal shape.", "A body 1014 is connected to the flange 1012 which is fluidly connected to conduit 1016.Conduit 1016 leads directly or indirectly to the collection canister.", "Conduit 1016 includes a main lumen 1110 used to provide a pathway for exudate between the wound “w” and the collection canister.", "A secondary lumen or vent lumen is provided in conduit 1016 to provide a controlled leak to the wound site.", "Exudate enters lumen 1110 at area 1114 and air exits lumen 1112 at area 1116.Secondary lumen 1112 is exposed to the ambient environment or to a source of air to provide a controlled leak in the wound port 1000.Although FIG.", "10B depicts lumens 1110 and 1112 in a single conduit 1016, lumens 1110 and 1112 can be provided as separate conduits.", "With reference to FIG.", "11A, in yet another embodiment, a wound dressing 1200 is shown having a wound port 1210.Wound dressing 1200 and wound port 1210 are similar to wound dressing 12, 112, and 212 and wound port 1210 are similar to wound port 30, 130 and 230 described hereinabove.", "A vent conduit 1220 may be inserted into the top of wound port 1210 to provide a source of filtered air into the wound dressing 1200 through the vent conduit 1220.Vent conduit 1220 may be a stainless steel needle having a lumen extending through the needle.", "The end of vent conduit 1220 has filter 1225 to filter the air from the ambient atmosphere.", "The low flow filtered air flowing from the ambient atmosphere through the vent conduit 1220, in combination with the high flow drainage occurring through an exudate conduit, creates a sump action between the wound and a collection canister.", "This sump action ensures continuous flow through exudate conduit 36, thereby preventing fluid stagnation and its complications.", "As discussed above, the difference in size between exudate conduit and vent conduit 1220 results in capillary action that causes fluid to flow only through the larger exudate conduit.", "FIGS.", "11B-11D depict a wound port 1210 similar to the wound port in FIG.", "11A.", "In FIGS.", "11B-11D, the vent conduit 1220 is placed on the side of the wound port 1210 rather than the top of the wound port 1210 as shown in FIG.", "11A.", "FIG.", "11D depicts the end of vent conduit 1220 being located in the wound port 1210 above an exudate orifice 1230.Although the foregoing disclosure has been described in some detail by way of illustration and example, for purposes of clarity or understanding, it will be obvious that certain changes and modifications may be practiced within the scope of the appended claims.", "For example, the individual fluid and vent conduits may be substituted for by a conduit having a dual lumen.", "To ensure the capillary action, one lumen must be larger than the other; however, the lumens may be coaxial or parallel." ] ]
Patent_15872810
[ [ "APPARATUS AND PROCESS FOR PREPARATION OF SMALL WATER CLUSTER AND SMALL MOLECULAR CLUSTER WATER PREPARED THEREFROM", "The invention provides an apparatus of treating water to obtain small water cluster, which comprises one or more illumination devices and one or more holders holding metal particles.", "The invention also provides a method of preparing the small water cluster and the small water cluster prepared from the apparatus or the method." ], [ "1.A water treatment apparatus for preparing small water cluster, comprising one or more illumination devices and one or more holders holding metal particles capable of surface plasma resonance, provided that the holder allows illumination of the metal particles.", "2.The apparatus of claim 1, wherein the holder is a transparent hollow column or hollow container having one or more inlets and one or more outlets and optionally the one or more outlets have a switching control valve, wherein the transparent hollow column or hollow container fills with metal particles capable of surface plasma resonance.", "3.The apparatus of claim 2, wherein the outlet of the column is narrower than the inlet of the column.", "4.The apparatus of claim 1, wherein the illumination device is a light source providing a wavelength ranging from 100 nm to 3,000 nm.", "5.The apparatus of claim 1, wherein the illumination device is a daylight lamp, LED lamp, lamp bulb, mercury lamp, metal halide lamp, sodium lamp or halogen lamp.", "6.The apparatus of claim 5, wherein the LED lamp is an LED green lamp.", "7.The apparatus of claim 1, wherein the metal particle is a nano-gold particle, a nano-silver particle, a nano-platinum particle, a nano-rhodium particle, a nano-copper particle, a nano-nickel particle, a nano-zirconium particle, a nano-alloy particle, a nano-TiO2 particle, a nano-gold/silver particle, a nano-gold/TiO2 particle, or a combination thereof.", "8.The apparatus of claim 1, wherein the metal particle is a nano-gold particle, nano-silver particle, nano-gold/silver particle or a nano-gold/TiO2 particle.", "9.The apparatus of claim 1, wherein the metal particle is deposited on the surface of ceramic or chitosan to for a nano-gold/ceramic particle or a nano-gold/chitosan particle.", "10.The apparatus of claim 1, wherein the size of the metal particle is 0.1 nm to 1,000 nm.", "11.The apparatus of claim 1, wherein the metal particle is spherical, cylindrical, elliptical, cuboidal or cubical in shape.", "12.A hemodialysis apparatus, comprising a hemodialysis bag or a hemodialysis column coated with nano-metal particles and an illumination device as stated in claim 1." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Water (H 2 O) is an inorganic material consisting of two elements, hydrogen and oxygen.", "Water is important for all organisms and is an essential element of organisms.", "The elements and molecular structure bestow it with unique properties, particularly the formation of hydrogen bond.", "In the structure of water, there are two receptors and two donors of forming hydrogen bonds, respectively; and various structures between water molecules are formed by hydrogen bond, such as tetrahedron structure like ice, dimer and polymer.", "Therefore, at the microenvironment level, the water molecule is called a “water cluster,” which is a water molecule cluster formed with discontinuous hydrogen structure.", "The hydrogen bonds of small water cluster are cleaved more easily to form individual water molecules, so the small water cluster has stronger diffusion power and faster absorption rate.", "Therefore, compared to the large water cluster, the small water cluster can readily pass through the water channel on a cell membrane and allow an ingredient to enter a cell easily and improve metabolism.", "After water is boiled or gasified, it will become small molecule water; however, after cooling it to room temperature, water molecules will form a large molecule cluster.", "A water cluster has an antioxidant effect after hydrogen gas is added; however, due to low solubility of hydrogen gas, the hydrogen gas will rapidly effuse to atmosphere.", "The solubility of solids and gas in water can be increased by elevating temperature and pressure; however, an additional apparatus and process are necessary to achieve this effect.", "More, after it returns to normal temperature and pressure, the solubility will return to the original state without increased solubility.", "Taiwan Patent No.", "M382845 discloses a filtration element with a composite layer and a filtration apparatus having the element, said composite layer consisting of nano noble metal chitosan composite, and the composite comprising a chitosan substrate and a number of nano noble metal particles adsorbed on the surface of the chitosan substrate.", "The harmful substances in a fluid can be removed after passing through the composite having the substrate and nano noble metal so as to achieve antibacteria and deodorization effects.", "Furthermore, the filtration and adsorption are improved in view of the adsorption of impurities by chitosan.", "However, the water treated by the apparatus still cannot achieve satisfactory small water cluster.", "U.S. Pat.", "No.", "5,800,576 provides water cluster compositions characterized by high oxygen reactivity due to protruding, delocalized pπ orbitals.", "The patent application uses a hypersonic nozzle containing nickel or nickel alloy, which is different from that of the prior art, to destroy the interaction between water molecules when water passes through the nozzle to obtain water clusters containing 5 to 300 water molecules and having high oxygen reactivity.", "However, the property only exists in the water microdroplets formed by instant spray.", "US 20110218251 A1 discloses a product having solid stable water clusters including a plurality of water molecules connected with one another by electrical dipole interaction via internal electric field of ions and having a permanent electric dipole moment with an electrical field surrounding the solid stable water clusters.", "The patent application discloses a product with stable solid water clusters, each sized from a nanometer to a micrometer and formed by the electrical dipole interaction surrounding the water cluster.", "The chamber having ultrapure water is filled with argon gas to avoid contact with carbon dioxide.", "After an additive (such as sodium chloride, vitamin, amino acid, hormone, protein, enzyme, polypeptide, polysaccharide, DNA, RNA) is introduced to the chamber, electrical dipole interaction occurs between the additive and water to form stable water clusters.", "However, the need in the patent application, for an additive means the resulting water is not pure water.", "US 20110089049 A1 provides an electrolytic method for treatment of water to increase the dissolved oxygen content; the method further aids the distribution and exposure of radicals through the water cluster.", "The patent application discloses a method of obtaining a single water cluster by confining a water molecule in an environment of nano-materials including nano-carbon tube or grapheme nano-layer and containing nitrogen, alloy, palladium, palladium-gold or palladium-silver, and the size of the water cluster is 0.5 to 100 nanometers.", "However, the method of the patent application cannot provide water continuously.", "US 20110039951A1 discloses a method including providing a nano-environment and confining heavy or light water in the nano-environment such that at least one water cluster forms.", "However, the water treated by the above method cannot achieve satisfactory small water cluster.", "US 20130056355A1 provides a water treatment system based on electric and magnetic fields, which employs water to pass through a pipe containing a rare earth alloy formed by lanthanum, yttrium, cerium, praseodymium, neodymium, samarium, titanium and zinc metal alloy and excites electrons of water to form an electric field and then pass through a pipe with a permanent magnet to create electric and magnetic fields to break hydrogen bonds between partial water molecules.", "However, the water treated by the above system cannot achieve satisfactory small water cluster.", "Moreover, too many various rare earth species are required.", "Therefore, there remains a need to develop a smaller water cluster in the art to obtain a small water cluster having increased diffusion power and better absorption rate, which is more beneficial to health." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The invention provides a water treatment apparatus for preparing small water cluster, comprising one or more illumination devices and one or more holders holding metal particles capable of surface plasma resonance.", "Preferably, the holder is a hollow light transparent column with one or more inlets and one or more outlets and the light transparent column is filled with metal particles capable of surface plasmon resonance.", "Accordingly, the invention provides a method for preparing small water cluster by using the apparatus of the invention.", "The invention also provides a small water cluster produced from the apparatus or method of the invention.", "In one embodiment, the small water cluster has a specific Raman spectrum, infrared absorption spectrum, evaporation rate, solubility, maximum amount of dissolved oxygen and vapor pressure." ], [ "FIELD OF THE INVENTION The invention relates to an apparatus and process for treating water and the water treated by the apparatus or process.", "Particularly, the invention provides an apparatus and process for preparing small water cluster and the small water cluster treated by the apparatus or process.", "BACKGROUND OF THE INVENTION Water (H2O) is an inorganic material consisting of two elements, hydrogen and oxygen.", "Water is important for all organisms and is an essential element of organisms.", "The elements and molecular structure bestow it with unique properties, particularly the formation of hydrogen bond.", "In the structure of water, there are two receptors and two donors of forming hydrogen bonds, respectively; and various structures between water molecules are formed by hydrogen bond, such as tetrahedron structure like ice, dimer and polymer.", "Therefore, at the microenvironment level, the water molecule is called a “water cluster,” which is a water molecule cluster formed with discontinuous hydrogen structure.", "The hydrogen bonds of small water cluster are cleaved more easily to form individual water molecules, so the small water cluster has stronger diffusion power and faster absorption rate.", "Therefore, compared to the large water cluster, the small water cluster can readily pass through the water channel on a cell membrane and allow an ingredient to enter a cell easily and improve metabolism.", "After water is boiled or gasified, it will become small molecule water; however, after cooling it to room temperature, water molecules will form a large molecule cluster.", "A water cluster has an antioxidant effect after hydrogen gas is added; however, due to low solubility of hydrogen gas, the hydrogen gas will rapidly effuse to atmosphere.", "The solubility of solids and gas in water can be increased by elevating temperature and pressure; however, an additional apparatus and process are necessary to achieve this effect.", "More, after it returns to normal temperature and pressure, the solubility will return to the original state without increased solubility.", "Taiwan Patent No.", "M382845 discloses a filtration element with a composite layer and a filtration apparatus having the element, said composite layer consisting of nano noble metal chitosan composite, and the composite comprising a chitosan substrate and a number of nano noble metal particles adsorbed on the surface of the chitosan substrate.", "The harmful substances in a fluid can be removed after passing through the composite having the substrate and nano noble metal so as to achieve antibacteria and deodorization effects.", "Furthermore, the filtration and adsorption are improved in view of the adsorption of impurities by chitosan.", "However, the water treated by the apparatus still cannot achieve satisfactory small water cluster.", "U.S. Pat.", "No.", "5,800,576 provides water cluster compositions characterized by high oxygen reactivity due to protruding, delocalized pπ orbitals.", "The patent application uses a hypersonic nozzle containing nickel or nickel alloy, which is different from that of the prior art, to destroy the interaction between water molecules when water passes through the nozzle to obtain water clusters containing 5 to 300 water molecules and having high oxygen reactivity.", "However, the property only exists in the water microdroplets formed by instant spray.", "US 20110218251 A1 discloses a product having solid stable water clusters including a plurality of water molecules connected with one another by electrical dipole interaction via internal electric field of ions and having a permanent electric dipole moment with an electrical field surrounding the solid stable water clusters.", "The patent application discloses a product with stable solid water clusters, each sized from a nanometer to a micrometer and formed by the electrical dipole interaction surrounding the water cluster.", "The chamber having ultrapure water is filled with argon gas to avoid contact with carbon dioxide.", "After an additive (such as sodium chloride, vitamin, amino acid, hormone, protein, enzyme, polypeptide, polysaccharide, DNA, RNA) is introduced to the chamber, electrical dipole interaction occurs between the additive and water to form stable water clusters.", "However, the need in the patent application, for an additive means the resulting water is not pure water.", "US 20110089049 A1 provides an electrolytic method for treatment of water to increase the dissolved oxygen content; the method further aids the distribution and exposure of radicals through the water cluster.", "The patent application discloses a method of obtaining a single water cluster by confining a water molecule in an environment of nano-materials including nano-carbon tube or grapheme nano-layer and containing nitrogen, alloy, palladium, palladium-gold or palladium-silver, and the size of the water cluster is 0.5 to 100 nanometers.", "However, the method of the patent application cannot provide water continuously.", "US 20110039951A1 discloses a method including providing a nano-environment and confining heavy or light water in the nano-environment such that at least one water cluster forms.", "However, the water treated by the above method cannot achieve satisfactory small water cluster.", "US 20130056355A1 provides a water treatment system based on electric and magnetic fields, which employs water to pass through a pipe containing a rare earth alloy formed by lanthanum, yttrium, cerium, praseodymium, neodymium, samarium, titanium and zinc metal alloy and excites electrons of water to form an electric field and then pass through a pipe with a permanent magnet to create electric and magnetic fields to break hydrogen bonds between partial water molecules.", "However, the water treated by the above system cannot achieve satisfactory small water cluster.", "Moreover, too many various rare earth species are required.", "Therefore, there remains a need to develop a smaller water cluster in the art to obtain a small water cluster having increased diffusion power and better absorption rate, which is more beneficial to health.", "SUMMARY OF THE INVENTION The invention provides a water treatment apparatus for preparing small water cluster, comprising one or more illumination devices and one or more holders holding metal particles capable of surface plasma resonance.", "Preferably, the holder is a hollow light transparent column with one or more inlets and one or more outlets and the light transparent column is filled with metal particles capable of surface plasmon resonance.", "Accordingly, the invention provides a method for preparing small water cluster by using the apparatus of the invention.", "The invention also provides a small water cluster produced from the apparatus or method of the invention.", "In one embodiment, the small water cluster has a specific Raman spectrum, infrared absorption spectrum, evaporation rate, solubility, maximum amount of dissolved oxygen and vapor pressure.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 refers to an illustrative drawing of one embodiment of the apparatus of the invention.", "FIG.", "2 refers to refers to an illustrative drawing of another embodiment of the apparatus of the invention.", "FIG.", "3 shows the ultraviolet-visible light absorption spectrum; (a) nano-gold water solution (solid line); (b) ceramic particles deposited with nano-gold (dashed line).", "FIG.", "4 shows the Raman spectrum of various water samples.", "FIG.", "5 shows the reduction of hydrogen bonds in water structures by small water cluster and deionized water.", "FIG.", "6 shows the effect of different light exposure times on the production of small water cluster.", "FIG.", "7 shows the infrared absorption spectrum of the small water cluster and the deionized water; (a) deionized water (dashed line); (b) small water cluster (solid line).", "FIG.", "8 shows the evaporation amount of the deionized water and the small water cluster per unit time (hour).", "FIG.", "9 shows the ability for removing DPPH free radicals by the small water cluster and the deionized water.", "FIG.", "10 shows the ability for removing hydroxyl free radicals in Fenton reagent by the small water cluster and the deionized water.", "FIG.", "11 shows the reduction of nitric oxide-releasing ability by the small water cluster in different LPS (an agent inducing cell inflammation) amounts.", "FIG.", "12 shows the voltammetric data at a scan rate of 0.1 V s21 recorded in different water-based saline solutions at a 3 mm diameter planar Pt electrode for different systems; (a) 30 mM K3Fe(CN)6 for one electron participating in the reaction; (b) 1 mM HQ for two electrons participating in the reaction.", "FIG.", "13 shows the anti-oxidative activity of AuNT water () and sAuNT water () compared to DI water () on reduction of lipopolysaccharide (LPS)-induced NO release with dose of LPS.", "Determination of nitric oxide (NO) production was made following the method shown in the literature (see SD).", "DI water, AuNT water and sAuNT water were used for medium preparation.", "*p=0.05; **p=0.01; ***p=0.001.FIGS.", "14 (a) and (b) show the removal efficiencies of BUN and Crea by using saline solutions based on different water; (a) removal efficiencies of BUN by using different saline solutions; treatment times for removal of 70% BUN (initially ca.", "100 mg dL21) are ca.", "30 and 16 min by using saline solution (DI) and using saline solution (sAuNT), respectively; (b) removal efficiencies of Crea by using different saline solutions.", "Treatment times for removal of 70% Crea (initially ca.", "20 mg dL21) are ca.", "29 and 12 min by using saline solution (DI) and using saline solution (sAuNT), respectively.", "FIGS.", "15 (a), (b) and (c) show in vitro haemodialysis simulation assay.", "During dialysis, AK column (B3-1.0A) was coated with nano-gold and subjected to illumination to remove BUN (a), Crea (b) and other medium molecules in blood (B12) (c).", "FIG.", "16 shows the gel electrophoresis of PCR reaction using the small water cluster of the invention.", "DETAILED DESCRIPTION OF THE INVENTION Due to the formation of hydrogen bonds, water exists in the form of tetrahedrally hydrogen-bonded water molecules (water cluster).", "The hydrogen bond in water will weaken as the water molecule receives energy, is subjected to high pressure or comprises an electrolyte so that the tetrahedral structure of the water is destroyed and small water clusters are formed.", "The invention combines the plasmon resonance effect of nano-metal particles and illumination providing energy to increase plasmon resonance effect to provide hot electrons to break hydrogen bonds in a water molecule cluster to form small water cluster with smaller molecular clusters.", "In one aspect, the invention provides a water treatment apparatus for preparing small water cluster, comprising one or more illumination devices and one or more holders holding metal particles capable of surface plasma resonance, provided that the holder allows illumination of the metal particles.", "According to the invention, any holder suitable to hold the metal particles of the invention can be used in the apparatus of the invention.", "Preferably, the holder is a container, transparent column or solid support.", "In one embodiment, the transparent column of the apparatus has one or more inlets and one or more outlets; preferably, the outlet of the column is narrower than the inlet of the column and has a switching control valve.", "In another embodiment, the solid support is a polymer support.", "In another embodiment, the container is a hollow container or a hollow container having one or more inlets and one or more outlets.", "Preferably, the hollow container is a shallow tray.", "Preferably, the wall of the hollow container is transparent.", "In one embodiment, the illumination device is a light source providing a wavelength ranging from 100 nm to 3,000 nm.", "Preferably, the light source provides a wavelength ranging from 380 nm to 780 nm; more preferably, 500 nm to 600 nm (preferably, 380 nm to 480 nm for nano-silver).", "According to one embodiment of the invention, the illumination device is a daylight lamp, LED lamp, lamp bulb, mercury lamp, metal halide lamp, sodium lamp or halogen lamp; preferably, LED green lamp.", "According to the invention, any transparent material can be used to prepare the transparent column of the invention.", "According to one embodiment of the invention, the transparent column is a glass column or plastic column.", "According to the invention, the holder holds or fills with metal particles capable of surface plasma resonance.", "Plasma is a physical state that occurs between metal and dielectric surfaces, and is formed by exciting a surface plasmon wave (SPW) between a thin metal layer and dielectric surface by employing electrons or photons.", "A TM-wave of incident light excites free electrons between the metal and surface of the medium by a coupler so that collective longitudinal resonance can be formed.", "According to one embodiment of the invention, the metal particle is a nano-metal particle; preferably, nano-gold particle, nano-silver particle, nano-platinum particle, nano-rhodium particle, nano-copper particle, nano-nickel particle, nano-zirconium particle, nano-alloy particle (such as ZrNiCu alloy), nano-TiO2 particle or a combination thereof.", "More preferably, it is a nano-gold particle, nano-silver particle, nano-gold/silver particle or nano-gold/TiO2 particle.", "According to another embodiment of the invention, the nano-metal particle can be combined with another material to form a composite; the metal in the composite is preferably gold, silver, platinum, rhodium, copper, nickel, zirconium or an alloy and the other material in the composite is preferably chitosan or ceramic.", "The composite includes, but is not limited to, nano-gold/ceramic particles or nano-gold/chitosan particles.", "According to another embodiment, the nano-metal particle is in a size of 0.1 nm to 1,000 nm; preferably, 1 nm to 100 nm.", "In another embodiment, the particle of the invention is spherical, cylindrical, elliptical, cuboidal or cubical shape.", "Any known method can be used in the preparation of the nano-particle of the invention.", "For example, laser ablation method, metal vapor synthesis method and chemical reduction method (such as electrochemical reduction and sonoelectrochemical reduction method).", "In another aspect, the invention provides a method for preparing a small water cluster, comprising providing a holder holding a plurality of metal particles capable of surface plasma resonance, contacting water with the nano-metal particles and illuminating the nano-metal particles to obtain the small water cluster.", "Preferably, the method is performed by using the apparatus of the invention; particularly, using any of embodiments of the apparatus of the invention described herein.", "The method of using the apparatus of the invention introduces water to the holder of the apparatus of the invention and illuminates the holder with the illumination device of the invention.", "After water passes through the metal particles, since the metal particles cause surface plasmon resonance (SPR), after illumination, a specific wavelength (about 538 nm in the invention) of energy can be absorbed to generate SPR effect to break partial hydrogen bonds in a water molecule cluster.", "The illumination in combination with plasmon resonance weakens the hydrogen bonds of water to form small water cluster.", "The small water cluster of the invention can stably exist for long time (at least three days) and has special properties and functions.", "FIG.", "1 is an illustrative figure of the apparatus of the invention.", "Referring to FIG.", "1, the apparatus of the invention has an illumination device 1 and a transparent column 2.The transparent column 2 has an inlet 5 and an outlet 6; the outlet 6 is narrower than the inlet 5.A switching control value 4 is equipped close to the outlet 6.The transparent column 2 fills with nano-gold/ceramic particles 3.The water to be treated enters into the transparent column 2 from the inlet 5.The illumination device 1 provides energy 7 (provided by daylight lamp or green LED illumination).", "After the nano-gold/ceramic particles absorb energy at a specific wavelength (for example about 538 nm), the surface plasmon resonance effect occurs to break partial hydrogen bonds of water molecules to form small water cluster.", "The switching control value 4 of the transparent column 2 is opened to collect the treated small water cluster from the outlet 6.FIG.", "2 is an illustrative figure of another embodiment of the apparatus of the invention.", "Referring to FIG.", "2, the apparatus of the invention has an illumination device 1 and an open hollow container 8.The open hollow container 8 has an inlet 9 and an outlet 10.The hollow container 8 fills with nano-gold/ceramic composite particles 3.The water to be treated enters into the hollow container 8 from the inlet 9.The illumination device 1 provides energy 7 by illumination (provided by daylight lamp or green LED illumination).", "After the nano-gold/ceramic particles absorb energy at a specific wavelength (for example about 538 nm), the surface plasmon resonance effect occurs to break partial hydrogen bonds of water molecules to form small water cluster.", "Then, the small water cluster is collected from the outlet 10.In another embodiment, the invention provides an apparatus, the devices of which and the connection thereof are similar to FIG.", "2, with the difference merely lying in that the hollow container does not have the inlets and outlets.", "In one embodiment, the illumination time in the invention is 5 minutes to 480 minutes; preferably, 5 minutes to 240 minutes or 10 minutes to 240 minutes.", "In another aspect, the invention provides a small water cluster produced from the apparatus or method of the invention.", "In one embodiment, the small water cluster has specific Raman spectrum, infrared absorption spectrum, evaporation rate and solubility etc.", "Raman spectroscopy is used to study interaction of water molecules.", "Raman shift of about 2600 to 4000 cm−1 represents the OH vibration of water molecules, and five bands can be identified within the range by Gaussian function deconvolution.", "The deconvolution of different water samples is to fix the positions of the five bands, and the central points of the five bands are about 3018 cm−1, about 3223 cm−1, about 3393 cm−1, about 3506 cm−1, and 3624 cm−1 in view of the fact that the full width at half maximum (FWHM) is the same of each water sample.", "The former three positions represent strong hydrogen bond and the latter two positions represent weak hydrogen bond and non-hydrogen bond, respectively (J. Raman Spectrosc.", "2009, 40, 1200; Vib.", "Spectrosc.", "2012, 62, pp.", "110-114; J. Chem.", "Phys.", "1998, Vol.", "108, No.", "7, pp.", "2669-2675).", "The integral area of the latter two bands divided by the sum of the integral area of the five bands is defined as the percentage of the non-hydrogen bond level (NHBL) in the water molecule sample.", "In detail, in the spectrum deconvolution, th signals of OH vibration are set at the positions about 3018 cm−1, about 3223 cm−1, about 3393 cm−1, about 3506 cm−1, and 3624 cm1, and the full width at half maximum (FWHM) is the same of each water sample.", "The non-hydrogen bond level is obtained by the integral area at the about 3506 cm−1 and about 3624 cm−1 positions divided by the sum of the integral areas of the five bands at about 3018 cm−1, about 3223 cm−1, about 3393 cm−1, about 3506 cm−1, and 3624 cm−1 positions.", "Generally, the non-hydrogen bond level of deionized water is 21.29%.", "When hydrogen bonds are broken, the Raman spectrum shows that the band strength (area) of strong hydrogen bond decreases, while the weak the strength (area) of hydrogen bond and non-hydrogen bond increases (J. Chem Phys.", "1981, 75, 4264).", "Therefore, Raman spectrum can be used to show the properties of the small water molecule cluster of the invention.", "In detail, the central points of the Raman bands in the deconvoluted spectrum on OH vibration of water are at the positions of about 3018 cm−1, about 3223 cm−1, about 3393 cm−1, about 3506 cm−1, and 3624 cm−1 respectively, and the non-hydrogen bond level obtained by the integral area at the about 3506 cm−1 and about 3624 cm−1 positions divided by the sum of the integral areas of the five bands at about 3018 cm−1, about 3223 cm−1, about 3393 cm−1, about 3506 cm−1, and 3624 cm−1 positions is higher than about 22%; preferably, larger than about 23%, about 24%, about 24.11%, about 25%, about 26%, about 27%, about 28%, about 29%, about 30%, 30.31%, about 31%, about 32%, about 33%, about 34%, or about 35%.", "More preferably, the non-hydrogen bond level of the small water cluster is about 24% to about 50%, about 24% to about 45%, about 24% to about 40% or about 24% to about 32%.", "In one embodiment, the Raman spectrum further comprises the Raman shifts at the positions of about 3506 cm−1 and 3624 cm−1 higher than about 15.0% and about 6%, respectively, wherein the the percentage is calculated by the integral area of the band at about 3506 cm−1 or at about 3624 cm−1 divided by the sum of the integral areas of the five bands at about 3018 cm−1, about 3223 cm−1, about 3393 cm−1, about 3506 cm−1, and 3624 cm−1 positions; preferably, about 16% and about 7% respectively, or about 16.7% and about 7.3% respectively.", "In this embodiment, the percentage represents the ratio of the integral area for one band at about 3506 cm−1 or at about 3624 cm−1 to the sum of the integral areas of the five bands at about 3018 cm−1, about 3223 cm−1, about 3393 cm−1, about 3506 cm−1, and 3624 cm−1 positions.", "The infrared spectrum (IR) showing OH vibration of water ranges from about 3090 to 3640 cm−1, which can be divided into two parts; the characteristic peak at wavelength of about 3090 to about 3310 cm−1 represents triple hydrogen bond (high density hydrogen bond) and the characteristic peak at wavelength of about 3310 to about 3640 cm−1 represents non-hydrogen bond, single hydrogen bond and doublet hydrogen bond (J. Phys.", "Chem.", "B, 2012, 116, 10609).", "According to one embodiment of the invention, the small water cluster has a specific IR spectrum, wherein the characteristic peak of the triple hydrogen bond (about 3090 to about 3310 cm−1) of water molecule and that of the non-hydrogen bond, single hydrogen bond and doublet hydrogen bond (about 3310 cm−1 to about 3640 cm−1) of water molecule shift from about 3170 cm−1 (the characteristic peak of deionized water) to about 3175 cm−1 and from about 3449 cm−1 to about 3454 cm−1, respectively.", "In detail, the characteristic peak of the triple hydrogen bond in the IR spectrum (about 3090 to about 3310 cm−1) and the non-hydrogen bond, single hydrogen bond and doublet hydrogen bond in the IR spectrum (about 3310 cm−1 to about 3640 cm−1) of the water molecule shift from about 3170 cm−1 to about 3175 cm−1 and from about 3449 cm−1 to about 3454 cm−1, respectively.", "Preferably, from about 3170 cm to more than about 3183 cm and from about 3449 cm−1 to more than about 3461 cm−1, respectively.", "According to another embodiment, compared to the deionized water, the small water cluster of the invention has higher evaporation rate.", "The evaporation rate of the small water cluster of the invention is more than 3%/hour higher than that of the deionized water; preferably, more than 7.2%/hour higher than that of the deionized water.", "The preferred range is 7 to 12%/one hour higher than that of the deionized water.", "The electric resistance is 18.2 MO cm using MilliQ system.", "According to another embodiment, the solubility of NaCl in the small water cluster of the invention at about 22.8° C. under about 1 atmosphere is more than about 37 g dL−1; preferably, about 41.3 g dL−1.The preferred range is about 38.5−1 to about 40.5 g dL−1.According to another embodiment, the maximum amount of dissolved oxygen of the small water cluster of the invention at about 22.8° C. under about 1 atmosphere is more than about 21 mg L−1; preferably, about 23.8 mg L−1.The preferred range is about 21.5 mg L−1 to 23.0 mg L−1.The apparatus and method of the invention can effectively break the strong hydrogen bond structure to form a weak hydrogen bond and non-hydrogen bond structure, which is the structure of the small water cluster of the invention.", "Thus, the small water cluster of the invention has specific properties and functions.", "In one embodiment, compared to the deionized water as control (in which the non-hydrogen bond level is about 21.29%), the non-hydrogen bond level of the small water cluster of the invention is about 24.11%.", "In comparison with the small water cluster of the invention and the deionized water, the non-hydrogen bond level increases about 13% ((24.11%-21.29%)/21.29%×100%).", "According to another embodiment, the free OH vibration (non-hydrogen bonding) of the small water cluster of the invention can form a hydrogen bond with polyethylene glycol 400 (PEG 400 having molecule weight of 400).", "Therefore, the measurement value of the solubility of the small water cluster in PEG 400 is smaller than the preparation value by more than about 2%; preferably, more than about 3%, more than about 4%, more than about 5%, more than about 6%, more than about 7%, more than about 8%, more than about 9% or more than about 10%.", "According to another embodiment, the saturated vapor pressure of the small water cluster of the invention at 25° C. is higher than that of the deionized water by more than about 3.0%; preferably, more than about 4%, more than about 5%, more than about 6%, more than about 7%, more than about 8%, more than about 9% or more than about 10%.", "Since the small water cluster of the invention is treated by the above-mentioned metal particles, according to another embodiment, the small water cluster of the invention will have metal residue that can be measured by inductively coupled plasma-mass spectrometer (ICP-MS).", "Preferably, the concentration of the residue is more than about 0.05 ppb; more preferably, more than about 0.1 ppb, more than about 0.2 ppb, more than about 0.3 ppb, more than about 0.4 ppb, more than about 0.5 ppb, more than about 0.6 ppb, more than about 0.7 ppb, more than about 0.8 ppb, more than about 0.9 ppb or more than about 1.0 ppb.", "The metal concentration in the deionized water is about 0.03 ppb.", "The small water cluster of the invention has specific properties different from common water; for example, increased solubility of solid and gas at normal temperature and pressure and weaker hydrogen bond between water molecules.", "In addition, the small water cluster of the invention at normal temperature and pressure can stably exist for a long time.", "For example, it can stably exist for at least two days; preferably three days.", "After the small water cluster of the invention mixes with other components, since the other components can combine with the non-hydrogen bond or weak hydrogen bond of the small water cluster, the small water cluster can retain its form and without aggregating and losing the properties and advantages of small water cluster.", "Therefore, the small water cluster of the invention has utility.", "The small water cluster of the invention has specific properties, so it can remove free radicals and inhibit NO release from cell inflammation to achieve anti-oxidation and anti-inflammation.", "In addition, the small water cluster of the invention can also be used as a hemodialysis solution to increase the removal rate of waste in blood and can be used as water for hemodialysis.", "Accordingly, the invention provides a use of the small water cluster of the invention as hemodialysis solution.", "The invention also provides a method for preparing a hemodialysis solution, comprising contacting a hemodialysis water with nano-metal particles and subjecting the resulting solution to illumination to obtain the small water cluster of the invention and using the resulting small water cluster to prepare the hemodialysis solution.", "The invention also provides a hemodialysis apparatus, comprising a hemodialysis bag or a hemodialysis column coated with nano-metal particles and an illumination device as mentioned herein.", "The treatment time for the removal of 70% blood urea nitrogen (BUN) and creatinine (Crea) in the hemodialysis using the small water cluster of the invention can be reduced by 47% and 59%, respectively.", "In addition, the small water cluster of the invention also can reduce NO production in a lipopolysaccharide (LPS)-induced inflammation reaction so that the hemodialysis is safer and more efficient.", "In another aspect, the invention provides use of the small water cluster of the invention in a PCR reaction.", "Compared to deionized water, the reaction rate can increase more than three-fold when the reaction is conducted with the small water cluster of the invention.", "This shows that the small water cluster of the invention can enhance PCR reaction.", "Since water per se has wide applications, the small water cluster of the invention can be used in cosmetic, aesthetic medical, medical pharmaceutical, energy industries and various chemical and physical products, so it has industrial applicability.", "EXAMPLES Example 1 Preparation of the Small Water Cluster of the Invention Nano-gold was sintered and deposited on the surface of ceramic particles (92% SiO2, 40 mesh) to prepare nano-gold/ceramic particles.", "A transparent glass column was filled with 1,000 mL of the nano-gold/ceramic particles.", "The deionized water flowed through the glass column at a flow rate of 1 mL/minute under illumination to produce the small water cluster of the invention.", "Example 2 Raman Spectrum of the Small Water Cluster of the Invention The surface plasmon resonance spectrum of the nano-gold particles was measured by Raman spectroscopy (Perkin Elmer Lambda 800/900).", "The sample was placed in a 3 mL quartz cell.", "Water was used as the background value and the scanning rate was 750 nm/minute.", "The largest absorption band of the nano-gold particle solution was at 519 nm (FIG.", "3(a)).", "The surface plasmon resonance spectrum of the nano-gold/ceramic particles was measured by Raman spectroscopy (Perkin Elmer Lambsa 800/900), the scanning rate was 750 nm/minute and the reflective signals were measured.", "The moist ceramic particles were used as the background value and the surface plasmon resonance spectrum of the nano-gold/ceramic particle solution was at 538 nm.", "According to the UV-visible light spectrum, it was found that that the largest absorption band of the red nano-gold solution is at 519 nm and that of the nano-gold deposited on ceramic particles was shifted to 538 nm.", "As shown in FIG.", "3 (b), the energy throughout the entire visible light zones can be absorbed by the nano-gold to produce the SPR effect.", "However, using the wavelength near 538 nm of the light source produces a stronger SPR effect.", "The Raman spectroscopy assay was conducted in de-ionized water (DI water; control), the small water cluster of Example 1 (SWC) and the filtrated water (CPT; positive control), wherein the production of the filtrated water was similar to that of the small water cluster; the difference between them is that the filtrated water flowed through the ceramic particles without nano-gold.", "The ultra-small water cluster (super-SWC) was prepared by placing the deionized water on the surface of the nano-gold/ceramic particles.", "0.5 mL of each of deionized water, the small water cluster and the filtrated water were placed in a round-bottom container with 0.7 cm of circle silver slice, respectively, and a micro Raman spectrometer (UniRAM-Raman) was used for measurement.", "After the microscope was focused on the surface of the silver slice, the sample was scanned at the wavelength of 532 nm within the range of 2,600 to 4,000 cm-1 at an exposure time of 1 second.", "After repetitive scanning 30 times, the OH vibration signal can be obtained and spectrum data analysis conducted.", "The Raman spectrum of the ultra-small water cluster was measured by distributing the deionized water moistened nano-gold-ceramic particles on the silver slice surface, and after focusing the microscope on the surface of the silver slice, scanning the sample under the same conditions as mentioned above.", "The Raman spectra results are shown in FIG.", "4.Spectrum deconvolution analysis was conducted by setting the OH vibration positions at 3018 cm−1, 3223 cm−1, 3393 cm−1, 3506 cm−1 and 3624 cm−1 and using the same full width at half maximum (FWHM) for each water sample.", "The 3506 cm−1 and 3624 cm−1 positions represent the area of the bands of weak hydrogen bond and non-hydrogen bond.", "The ratio of this area to that of the entire OH vibration bands is defined as non-hydrogen bond level (including weak-hydrogen bond level and non-hydrogen bond level).", "Using deionized water as the control (the non-hydrogen bond level is 21.29%), the non-hydrogen bond level of the small water cluster is 24.11%.", "The non-hydrogen bond level of the small water cluster represents a 13% increase compared to the deionized water.", "The non-hydrogen bond level of the filtered water is 21.80%, which is similar to that of the deionized water.", "The non-hydrogen bond level of the ultra-small water cluster is 30.31%.", "Compared to the deionized water, the non-hydrogen bond level of the ultra-small water cluster is 42% higher.", "When the small water cluster is prepared in the absence of illumination, the non-hydrogen bond level is 21.50%, which is similar to the deionized water.", "Apparently, the illumination is an essential element to prepare the small water cluster.", "The non-hydrogen bond levels of the small water cluster prepared by using nano-silver, nano-platinum, nano-gold/TiO2 composite and nano-gold/silver composite are 24.36%, 23.76%, 24.17% and 24.94%.", "This shows that other nano-noble metals and other nano-metal composites can be used to prepare the small water cluster of the invention.", "Non- Raman shift (cm−1) hydrogen 3018 3223 3393 3506 3624 bond level Deionized 5.29% 40.22% 33.20% 15.66% 5.63% 21.29% water Small water 3.93% 38.31% 33.65% 16.78% 7.33% 24.11% cluster Filtrated 5.26% 40.17% 33.33% 15.40% 5.83% 21.24% water Ultra-small 1.19% 35.30% 33.20% 20.36% 9.95% 30.31% water cluster a 5.23% 39.72% 33.54% 15.71% 5.80% 21.50% b 4.59% 37.96% 33.10% 17.57% 6.78% 24.36% c 3.72% 38.49% 34.04% 17.59% 6.17% 23.76% d 4.09% 38.76% 32.97% 17.29% 6.89% 24.17% e 4.49% 35.72% 34.84% 20.11% 4.83% 24.94% a: Preparation of small water cluster without illumination b: Preparation of small water cluster using nano-silver particles c: Preparation of small water cluster using nano-platinum particles d: Preparation of small water cluster using nano-gold/nano-TiO2 composite e: Preparation of small water cluster using nano-gold/nano-silver composite Example 3 Reduction of Hydrogen Bond of Small Water Cluster of the Invention Using the deionized water (0% small water cluster) as control (non-hydrogen bond level is 21.29%), the small water cluster of Example 1 is 24.11%.", "Compared to the deionized water, the non-hydrogen bond level of the small water cluster is 13% higher.", "When the ratios of the small water cluster are 25% (non-hydrogen bond level is 21.84%), 50% (non-hydrogen bond level is 22.89%) and 75% (non-hydrogen bond level is 23.33%), the non-hydrogen bond levels increase 2.6%, 7.5% and 9.6%, which shows a linear relationship between the concentration of the small water cluster (SWC) and the non-hydrogen bond level (NHBL) (see FIG.", "5) with that in the small water cluster; the strong hydrogen bonds are broken to form weak hydrogen bonds and non-hydrogen bonds to form the structure of the small water cluster.", "Therefore, the small water cluster has specific properties and functions.", "Example 4 Effects of Different Illumination Time and Different Light Source in Preparation of Small Water Cluster of the Invention 20 mL of the deionized water (DI water) was added to a 50 mL glass bottles with 20 mL nano-gold/ceramic particles.", "The bottles were placed on shakers with regular shaking frequency and illuminated with different light sources.", "The water samples were taken at different time points and measured by Raman spectroscopy to obtain OH vibration signals for band deconvolution assay to determine non-hydrogen bond level (NHBL).", "After illumination with a daylight lamp and LED green lamp (wavelength of 530 nm) for 240 minutes, the non-hydrogen bond levels of the small water cluster illuminated by both daylight lamp and LED lamp can achieve a saturation value of about 24.4%.", "However, using the LED green lamp for illumination provides energy concentrated at 530 nm wavelength and can produce a stronger SPR effect, so after about 10 minutes, the saturation value can be achieved.", "However, when the daylight lamp is used for illumination, the saturation value is achieved after about 120 minutes (see FIG.", "6).", "Example 5 Infrared Absorption Spectrum (IR) of Small Water Cluster of the Invention Fourier-Transform Infrared Spectra of the deionized water (DI water; control) and the small water cluster (SWC) were measured by Fourier-Transform Infrared Spectrometer (Bruker-Tensor 27); the spectrum resolution was 8 cm−1, and the scanning was repeated 30 times; the sample was injected into a Precision Demountable Cell of International Crystal and the thickness of polytetrafluoroethene separator was 0.015 mm.", "The OH vibration of water ranging from about 3090 to 3640 cm−1 can be divided to two parts; the characteristic peak at wavelength of about 3090 to about 3310 cm−1 represents triple hydrogen bond (high density hydrogen bond) and the characteristic peak at wavelength of about 3310 to about 3640 cm−1 represents non-hydrogen bond, single hydrogen bond and doublet hydrogen bond (J. Phys.", "Chem.", "B, 2012, 116, 10609).", "After the deionized water was treated with nano-gold/ceramic particles, the characteristic peaks shifted to 3170 to 3183 cm−1 and 3449-3461 cm−1, respectively (see FIG.", "7).", "This shows that the interaction between water molecules becomes weakened (Phys.", "Chem.", "Chem.", "Phys., 1999, 1, 4619), so nano-gold/ceramic particle treatment can break the hydrogen bonds between water molecules to form small water cluster.", "Example 6 Vaporization Rate of Small Water Cluster of the Invention Compared to the deionized water (DI water; control), the small water cluster (SWC) of Example 1 shows a 13% increase in non-hydrogen bond level.", "Therefore, at normal temperature and pressure, the small water cluster evaporates quicker than the deionized water.", "However, after a period of time, the weak hydrogen bond and non-hydrogen bond levels of the small water cluster become the same as those of the deionized water, at which point the vaporization rate of the both will be the same.", "When preparing the small water cluster, the deionized water was placed in a flask with 20 mL nano-gold/ceramic particles on a plate shaking at a regular frequency so that the small water cluster produced on the surface of the nano-gold/ceramic particles can evaporate and separate from the particle surface and then the small water cluster can be continuously produced on the particle surface.", "80 mL deionized water was added to a 250 mL flask and 80 mL water was added to a flask with 20 mL nano-gold/ceramic particles.", "The two flasks were placed on a plate shaking at a regular frequency and the reduced water amounts in the two flasks were measured hourly for 7 hours to determine the evaporated water amount.", "Each hour, the evaporated water amount of the deionized water and small water cluster may vary, whereas the evaporated water amount of the small water cluster is more than 3% higher than the deionized water.", "On average, the evaporated water amount of the small water cluster is 7.2% higher than the deionized water (see FIG.", "8).", "Example 7 Solubility of Small Water Cluster of the Invention 20 mL of each the small water cluster (SWC) of Example 1 and the deionized water (DI water) were added to sample bottles, respectively.", "Excess NaCl was added to the solutions, which were then mixed for 30 minutes.", "After standing for 30 minutes, the both bottles had unsolved solute.", "The 1 mL of saturated solution was weighed to determine the solubility of NaCl in 100 mL water of each solution.", "Moreover, solubility of tapimycin was also determined.", "1.2 g of tapimycin was measured and added to each of two sample bottles.", "Then, the small water cluster and the deionized water were added to the bottles as solvent, respectively.", "After continuous mixing until no unsolved powder remained, the solute was totally solved to form a clear gel-like solution.", "The solubility of tapimycin per 100 mL water can be obtained based on the water (mL) needed to solve 1.2 g tapimycin.", "The maximum amount of dissolved oxygen of the small water cluster of the invention was further measured.", "40 mL of the small water cluster and the deionized water were added to 50 mL sample bottles, respectively.", "Gaseous oxygen was added to each water in bubble form for 30 minutes and the cap of each bottle was screwed tightly.", "After the water was left standing 5 minutes, the maximum amount of dissolved oxygen was measured by a portable dissolved oxygen meter (Lutron Electronic Enterprise Co., Ltd., Taiwan, Model: DO-5510).", "The table below shows the solubility of different solutes in the small water cluster and the deionized water.", "TABLE The solubility of different solutes in the small water cluster and the deionized water (1 atm, 22.8° C.) NaCl Tapimycin Oxygen (g dL−1) (g dL−1) (mg L−1) Small water cluster 41.3 140.6 23.8 Deionized water 36.2 104.5 20.3 It can be found from the above table that compared to the deionized water, the solubility of NaCl, tapimycin and oxygen in the small water cluster was 14%, 35% and 17% higher, respectively.", "This shows that the structure of the small water cluster is different from normal water and can effectively increase the solubility of solids and gas in water.", "Example 8 Measurement of Amount of Small Water Cluster Dissolved in PEG400 The deionized water and the small water cluster were added to PEG400 solutions, respectively, to prepare a solution containing 10 wt % water.", "The water amounts in PEG400 solutions prepared by the deionized water and the small water cluster of the invention were measured by a moisture meter; the results were 10.97 wt % for deionized water and 10.44 wt % for the small water cluster of the invention.", "Since the small water cluster contains more free and available OH groups for vibration, it can form hydrogen bonds with PEG400 and the water molecules forming the hydrogen bond cannot react with Karl Fischer reagent, and thus the measured value is 4.8% less than the prepared value.", "Example 9 Saturated Vapor Pressure of Small Water Cluster of the Invention The measurement system was vacuumed before the experiment to remove other gas and then an appropriate amount of water was subjected to the system to start the experiment.", "The vapor pressure at 25° C. was measured at different time points until the vapor pressure remained constant.", "The constant vapor pressure is the saturated vapor pressure at this certain temperature.", "After 6 hours, the saturated vapor pressure of the deionized water and the small water cluster was 0.0316 bar and 0.0344 bar, respectively.", "Therefore, at the temperature of 25° C., the saturated vapor pressure of the small water cluster is higher than that of the deionized water by 8.9%.", "TABLE The saturated vapor pressure of the deionized water and the small water cluster at 25° C. 0 min (bar) 30 min (bar) 3 h (bar) 6 h (bar) Deionized water 0.0208 0.0313 0.0313 0.0316 (24.8° C.) Small water 0.0327 0.0356 0.0354 0.0344 cluster (24.7° C.) Example 10 Assay of Removing DPPH Free Radicals by Small Water Cluster of the Invention DPPH.", "(free radical of 2,2-diphenyl-1-pricrylhydrazyl) is a stable free radical customarily used in the measurement of electron paramagnetic resonance (EPR) (Journal of Food and Nutrition Research, Vol.", "45, 2006, No.", "1, pp.", "1-11).", "DPPH in methanol or ethanol solution can be stably produced and detected by EPR.", "However, when it is reduced by antioxidants (AH) or free radicals (R.), the free radicals, DPPH., will be eliminate or reduced, so EPR measurement can be used to determine the ability of the small water cluster to remove free radicals.", "DPPH was added to methanol to obtain 4 nM DPPH in methanol solution.", "Different solutions with the ratios of the small water cluster to the deionized water were mixed with the 4 mM DPPH methanol solution in 1:1 volume ratio, respectively (the final concentration of DPPH is 2 mM), and then subjected to EPR measurement (Bruker EMX ESR spectrometer) after standing for two hours in the dark.", "The deionized water (0% small water cluster) was used as control and its EPR strength was 4033, while the ability of the small water cluster to remove DPPH free radicals was 24% higher.", "When the small water cluster is at a concentration of 25%, the EPR strength is 3783; at a concentration of 50%, the EPR strength is 3675; and at a concentration of 75%, the EPR strength is 3416 (see FIG.", "9).", "The ability to remove DPPH free radicals is 6.2%, 8.9% and 15% for 25%, 50% and 75% small water cluster higher, respectively.", "It shows a linear relationship between the concentration of the small water cluster and removal of the free radical and that the small water cluster can effectively remove DPPH free radicals.", "Example 11 Assay of Removing OH Free Radicals by Small Water Cluster of the Invention Fenton's reagent can produce strong oxidative and non-selective OH free radical (.OH) in a reaction of H2O2 and Fe2+ ion and the .OH can oxidize the hard-degradable organic materials in wastewater.", "However, the OH free radical is a strong oxidant and thus may damage cell membranes, vessel walls, proteins and genes, cause aging and disease in the human body, and is harmful to human health.", "Since the OH free radicals produced by Fenton's reagent decay very rapidly, DMPO (5,5-dimethyl-1-pyrroline-N-oxide) should be added to capture the free radicals to produce DMPO—OH free radicals.", "Then, the free radical strength can be measured by EPR.", "Fenton's reagent reaction was conducted to produce OH free radicals, to which 140 μL of deionized water (control group), the small water cluster and the filtrated water (positive control) were added, respectively.", "The filtrated water and small water cluster were produced in the same way as described in Example 2.Then, 20 μL phosphate buffer, 20 μL of 500 μM EDTA (Fe2+/Ethylenediaminetetraacetic acid), 10 μL of 200 μM H2O2 and 10 μL of 2M DMPO were added to the solution.", "After reaction, DMPO—OH signal was measured by EPR.", "The Fenton's reagent prepared by the deionized water was used as the control group and that prepared by the small water cluster of the invention was used as experimental group.", "The results show that the small water cluster can effectively remove 63% of the free radicals.", "It was also found that the filtrated water cannot remove the free radicals.", "The above results show that the removal of free radicals is caused by the surface plasmon resonance effect after illuminating the nano-gold deposited on the surface of the ceramic particles (see FIG.", "10).", "Example 12 Assay of Reduction of NO Release by Small Water Cluster of the Invention When the body's immune system is stimulated by a microorganism or its secreted substance (such as lipopolysaccharide (LPS) or lipoteichoic acid), reactive oxygen species (ROS) can be produced and production of NO induced.", "As a result, various inflammation reactions can be caused.", "The measurement of the amount of NO was conducted by culturing RAW 264.7 cells, a rat macrophage cell line, purchased from American Type Culture Collection (ATCC) in a medium containing bovine fetal serum (10%), penicillium (100 unit/mL) and streptomycin (100 μg mL−1) at 37° C. under 5% CO2.After cultivation, the medium was added to the 96-well plate in a concentration (2×105 cells/well) and then different concentrations of E. coli LPS (0-100 ng mL−1) were added to the wells for cultivation for 24 hours.", "100 μL of the medium was reacted with 100 μL of Griess reagent at room temperature for 10 minutes and the absorption value at 570 nm wavelength was measured by spectrophotometer (Labsystems, Helsinki, Finland) (Lin H C, Tsi S H, Chen C S, Chang Y C, Lee C M, Lai Z Y, Lin C M. Structure-activity relationship of coumarin derivatives on xanthine oxidase-inhibiting and free radical-scavenging activities.", "Biochemical Pharmacology.", "2008, 75: 1416-1425).", "The amount of LPS was increased from 10 ng mL−1 to 25 ng ml−1, 50 ng mL−1, 75 ng mL−1 and 100 ng mL−1, and the small water cluster (SWC) of Example 1 was used as the solvent of the medium.", "Compared to the deionized water (DI water) as the solvent of the medium, the NO release amounts in the above concentrations of the small water cluster were 1.0%, 11.5%, 14.1%, 13.7% and 16.2% lower, respectively, so it shows that the small water cluster can effectively reduce the inflammation induced by LPS (see FIG.", "11).", "Example 13 Stability Assay of Small Water Cluster of the Invention At 0, 1, 2, 3 and 5 days after preparation of the small water cluster of Example 1, the non-hydrogen bond levels were 24.11%, 23.52%, 23.11%, 22.11% and 21.39%, respectively.", "Compared to the non-hydrogen bond level of the deionized water, the small water cluster can stably exist for at least 3 days.", "Example 14 Diffusion Assay of Small Water Cluster of the Invention The water treated with nano-gold in combination with illumination has a weak hydrogen bond, which is responsible for its novel diffusion properties.", "FIG.", "12 shows cyclic voltammograms in different water-based saline solutions (DI water-NaCl for the saline prepared by deionized water; AuNT water-NaCl for the saline prepared by the small water cluster treated by the nano-gold in combination with illumination by daylight lamp; and sAuNT water-NaCl for the saline prepared by the molecular cluster water treated by the nano-gold in combination with illumination by green LED lamp) for K3Fe(CN)6 (FIG.", "12(a)) and hydroquinone (HQ) (FIG.", "12 (b)), from which the diffusion coefficients of K3Fe(CN)6 and HQ in saline solution can be obtained.", "Encouragingly, the calculated diffusion coefficient of K3Fe(CN)6 increased from 2.76×10−6 cm s−1 (1.78×10−6 cm s−1 for HQ) to 3.59×10−6 cm s−1 (2.0×10−6 cm s−1 for HQ) when using AuNT water instead of conventional DI water.", "This is an increase of 30% (12% for HQ) for the diffusion coefficient.", "This increased to 67% (24% for HQ) using AuNT water prepared using green LED illumination (4.62×10−6 cm s−1 for K3Fe(CN)6; 2.20×10−6 cm s−1 for HQ).", "From the above results, the diffusion effect of the untreated saline prepared by deionized water is the worst, and that of the saline prepared by the small water cluster treated by the nano-gold in combination with illumination by green LED lamp (sAuNT water-NaCl) is better than the saline prepared by the small water cluster treated by the nano-gold in combination with illumination by daylight lamp (AuNT water-NaCl).", "Example 15 Blood Dialysis Assay of Small Water Cluster of the Invention As shown in Example 1, water was treated by nano-gold surface plasmon resonance to obtain the small water cluster and then the small water cluster was used to prepare the hemodialysis solution.", "The reduction of NO release induced by LPS mentioned in Example 12 was used to evaluate the anti-inflammation effect of the small water cluster.", "FIG.", "13 shows the anti-inflammation effect of the hemodialysis solutions prepared by AuNT water-NaCl and sAuNT water-NaCl, which is evaluated by the reduction of NO release induced by LPS, compared to the hemodialysis solution prepared by DI water-NaCl.", "As shown in FIGS.", "14 (a) and (b), the treatment times for the removal of 70% BUN (100 mg dL21) in blood are ca.", "30 and 16 min using saline solution (DI) and saline solution (sAuNT), respectively (see FIG.", "14 (a)).", "The treatment times for the removal of 70% Crea (20 mg dL21) in blood are ca.", "29 and 12 min using saline solution (DI) and saline solution (sAuNT), respectively.", "These results suggest that the treatment times for the removal of 70% BUN and Crea can be reduced by 47% and 59%, respectively, using AuNT water instead of DI water in dialysate of saline solution (see FIG.", "14 (b)).", "As shown in the above results, the hemodialysis effect of the untreated saline prepared by deionized water is the worst, and that of the saline prepared by the small water cluster treated by the nano-gold in combination with illumination by green LED lamp (sAuNT water-NaCl) is better than the saline prepared by the small water cluster treated by the nano-gold in combination with illumination by daylight lamp (AuNT water-NaCl).", "Alternatively, to conduct an in vitro hemodialysis assay, the AK column (B3-1.0A) used in hemodialysis was coated with nano-gold and illuminated during the hemodialysis and the small water cluster were simultaneously produced.", "The samples containing BUN, Crea and other medium molecules (B12) were passed through the AK columns with different flow rates wherein “untreated” represents the AK column without the nano-gold coating and illumination and the “AuNP treated in LED” represents the AK column coated with the nano-gold and treated with illumination by green LED lamp.", "The hemodialysis solutions were prepared by DI water.", "The results are shown in FIGS.", "15 (a), (b) and (c).", "FIG.", "15 (a) shows the efficiency of removing BUN, FIG.", "15 (b) shows the efficiency of removing Crea and FIG.", "15 (c) shows the efficiency of removing B12.As shown in FIG.", "15, the removal rates of BUN, Crea and B12 by the AK column coated with nano-gold in combination with illumination are better than that of the untreated AK column.", "Example 16 PCR Reaction Using Small Water Cluster of the Invention The small water cluster of Example 1 was used to conduct a PCR reaction using 1 mg DNA template, 0.5 nM primer, 0.2 mM dNTP and 0.5 U/ml Taq polymerase.", "Then, the PCR product was subjected to electrophoresis with TAE argose gel.", "The qnrB bacterial gene fragment was used to conduct a PCR reaction in the small water cluster; the PCR rate of the product A (amplified qnrB bacterial gene fragment) increased 20-fold compared to the deionized water.", "The result shows that the small water cluster can effectively increase the PCR reaction rate (see FIG.", "16)." ] ]
Patent_15872812
[ [ "STERILIZATION DEVICE", "A sterilization device includes: a treatment chamber with a discharge valve provided on a downstream side of the treatment chamber; a light source that irradiates a fluid stored temporarily in the treatment chamber with ultraviolet light; and a heat exchange chamber connected to an upstream side of the treatment chamber via a gate valve.", "The heat exchange chamber is thermally connected to the light source.", "The sterilization device may further include a heat pipe that thermally connects the light source and the heat exchange chamber.", "The heat pipe may be provided to extend vertically upward from the light source toward the heat exchange chamber." ], [ "1.A sterilization device, comprising: a treatment chamber with a discharge valve provided on a downstream side of the treatment chamber; a light source that irradiates a fluid stored temporarily in the treatment chamber with ultraviolet light; and a heat exchange chamber connected to an upstream side of the treatment chamber via a gate valve, the heat exchange chamber being thermally connected to the light source.", "2.The sterilization device of claim 1, further comprising a heat pipe that thermally connects the light source and the heat exchange chamber.", "3.The sterilization device of claim 2, wherein the heat exchange chamber is provided on a vertically upper side of the treatment chamber, and the heat pipe is provided to extend vertically upward from the light source toward the heat exchange chamber.", "4.The sterilization device of claim 1, wherein the treatment chamber is formed of a material transmitting ultraviolet light emitted by the light source.", "5.The sterilization device of claim 4, wherein the heat exchange chamber is formed of a material having higher thermal conductivity than the material of the treatment chamber.", "6.The sterilization device of claim 1, further comprising a control device that controls operations of the light source, the discharge valve, and the gate valve, wherein the control device turns on the light source in a state where each of the treatment chamber and the heat exchange chamber stores a fluid, and both the discharge valve and the gate valve are closed." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>A sterilization device according to an embodiment of the present invention includes: a treatment chamber with a discharge valve provided on a downstream side of the treatment chamber; a light source that irradiates a fluid stored temporarily in the treatment chamber with ultraviolet light; and a heat exchange chamber connected to an upstream side of the treatment chamber via a gate valve.", "The heat exchange chamber is thermally connected to the light source.", "According to this embodiment, when a fluid stored in the treatment chamber is irradiated with ultraviolet light for sterilization treatment, by storing a fluid in the heat exchange chamber located on the upstream side of the treatment chamber, heat generated by the light source can be cooled using the fluid in the heat exchange chamber.", "Since the fluid stored in the heat exchange chamber is transferred to the treatment chamber so as to be sterilized next, and since a fluid is newly supplied to the heat exchange chamber, the light source can be cooled using a new fluid in each sterilization treatment.", "Therefore, according to the present embodiment, the light source can be suitably cooled using a relatively simple cooling means, without a circulation passage for water cooling.", "The sterilization device may further include a heat pipe that thermally connects the light source and the heat exchange chamber.", "The heat exchange chamber may be provided on a vertically upper side of the treatment chamber, and the heat pipe may be provided to extend vertically upward from the light source toward the heat exchange chamber.", "The treatment chamber may be formed of a material transmitting ultraviolet light emitted by the light source.", "The heat exchange chamber may be formed of a material having higher thermal conductivity than the material of the treatment chamber.", "The sterilization device may further include a control device that controls operations of the light source, the discharge valve, and the gate valve.", "The control device may turn on the light source in a state where each of the treatment chamber and the heat exchange chamber stores a fluid, and both the discharge valve and the gate valve are closed." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a Continuation of co-pending Application No.", "PCT/JP2016/075192 filed on Aug. 29, 2016, for which priority is claimed under 35 U.S.C.", "§ 120; and this application claims priority of Application No.", "2015-176158, filed in Japan on Sep. 7, 2015 under 35 U.S.C.", "§ 119; the entire content of all of which are incorporated herein by reference.", "BACKGROUND OF THE INVENTION 1.Field of the Invention The present invention relates to a sterilization device, and particularly to a device for irradiating a fluid with ultraviolet light for sterilization.", "2.Description of the Related Art Ultraviolet light is known for its sterilization capability, and devices for emitting ultraviolet light are used for sterilization treatment in the field of medical treatment, food processing, or the like.", "There are also devices used to irradiate a fluid, such as water, stored in a treatment tank with ultraviolet light so as to sterilize the fluid.", "Since a light source for emitting ultraviolet light is affected by heat generated during the light emission, the light source is used while being appropriately cooled.", "For example, the light source can be cooled by circulating the water stored in the treatment tank using a pump.", "Although a water-cooling system, having higher cooling efficiency, would be desirable in order to appropriately cool a light source, if a drive source, such as a pump, or a passage needs to be newly provided for water cooling, it may cause an increase in the number of necessary parts or in power consumption due to driving of the pump.", "Also, in the field of medical treatment or food processing, various devices have been often installed already, so that a smaller device would be desirable in consideration of restriction of space or the like.", "The present invention has been made in view of such a problem, and an illustrative purpose thereof is to provide a small sterilization device with a simplified means for cooling a light source.", "SUMMARY OF THE INVENTION A sterilization device according to an embodiment of the present invention includes: a treatment chamber with a discharge valve provided on a downstream side of the treatment chamber; a light source that irradiates a fluid stored temporarily in the treatment chamber with ultraviolet light; and a heat exchange chamber connected to an upstream side of the treatment chamber via a gate valve.", "The heat exchange chamber is thermally connected to the light source.", "According to this embodiment, when a fluid stored in the treatment chamber is irradiated with ultraviolet light for sterilization treatment, by storing a fluid in the heat exchange chamber located on the upstream side of the treatment chamber, heat generated by the light source can be cooled using the fluid in the heat exchange chamber.", "Since the fluid stored in the heat exchange chamber is transferred to the treatment chamber so as to be sterilized next, and since a fluid is newly supplied to the heat exchange chamber, the light source can be cooled using a new fluid in each sterilization treatment.", "Therefore, according to the present embodiment, the light source can be suitably cooled using a relatively simple cooling means, without a circulation passage for water cooling.", "The sterilization device may further include a heat pipe that thermally connects the light source and the heat exchange chamber.", "The heat exchange chamber may be provided on a vertically upper side of the treatment chamber, and the heat pipe may be provided to extend vertically upward from the light source toward the heat exchange chamber.", "The treatment chamber may be formed of a material transmitting ultraviolet light emitted by the light source.", "The heat exchange chamber may be formed of a material having higher thermal conductivity than the material of the treatment chamber.", "The sterilization device may further include a control device that controls operations of the light source, the discharge valve, and the gate valve.", "The control device may turn on the light source in a state where each of the treatment chamber and the heat exchange chamber stores a fluid, and both the discharge valve and the gate valve are closed.", "BRIEF DESCRIPTION OF THE DRAWINGS Embodiments will now be described, by way of example only, with reference to the accompanying drawings which are meant to be exemplary, not limiting, and wherein like elements are numbered alike in several Figures, in which: FIG.", "1 is a vertical sectional view that schematically shows a configuration of a sterilization device according to an embodiment; FIG.", "2 is a horizontal sectional view that schematically shows a configuration of the sterilization device shown in FIG.", "1; and FIG.", "3 is a flowchart that shows an operational process of the sterilization device.", "DETAILED DESCRIPTION OF THE INVENTION The invention will now be described by reference to the preferred embodiments.", "This does not intend to limit the scope of the present invention, but to exemplify the invention.", "Hereinafter, a mode for carrying out the present invention will be described in detail with reference to the drawings.", "In the description, like reference characters designate like elements, and the same description thereof will be appropriately omitted.", "FIG.", "1 is a vertical sectional view that schematically shows a configuration of a sterilization device 10 according to an embodiment, and FIG.", "2 is a horizontal sectional view that schematically shows a configuration of the sterilization device 10 shown in FIG.", "1.FIG.", "2 shows a section taken along line A-A in FIG.", "1, and FIG.", "1 shows a section taken along line B-B in FIG.", "2.The sterilization device 10 is a device that stores a fluid, such as drinking water, in a treatment chamber 48 and irradiates the fluid with ultraviolet light for sterilization treatment.", "Light emitting elements 20 as a light source for emitting ultraviolet light are thermally connected to a heat exchange vessel 14 via substrates 22 and heat pipes 24.Accordingly, the sterilization device 10 can perform sterilization treatment while cooling the light emitting elements 20 with a fluid stored in a heat exchange chamber 46.The sterilization device 10 comprises a casing 12, the heat exchange vessel 14, a treatment vessel 16, the light emitting elements 20, the substrates 22, the heat pipes 24, an inflow pipe 30, a connection pipe 32, a discharge pipe 34, an inflow valve 40, a gate valve 42, a discharge valve 44, and a control device 50.The casing 12 has a cylindrical shape and houses the heat exchange vessel 14 and the treatment vessel 16 therein.", "The casing 12 is made of a metal material or resin material, for example.", "The inflow pipe 30 is provided on an upper end of the casing 12, and the discharge pipe 34 is provided on a lower end of the casing 12.In the present specification, the side on which the inflow pipe 30 is provided will be referred to as the upstream side, and the side on which the discharge pipe 34 is provided will be referred to as the downstream side.", "Within the casing 12, the heat exchange vessel 14 is provided on the upstream side of the treatment vessel 16, and the treatment vessel 16 is provided on the downstream side of the heat exchange vessel 14.Also, in the present embodiment, the inflow pipe 30 is provided on a vertically upper side, and the discharge pipe 34 is provided on a vertically lower side.", "Namely, in the present embodiment, the upstream side means the vertically upper side, and the downstream side means the vertically lower side.", "The heat exchange vessel 14 has a cylindrical shape corresponding to the casing 12 and forms the heat exchange chamber 46.The heat exchange vessel 14 would be suitably constituted by a member having high thermal conductivity and is formed of a metal material, such as copper (Cu) and aluminum (Al).", "To the upstream side of the heat exchange vessel 14 is connected the inflow pipe 30, and to the downstream side of the heat exchange vessel 14 is connected the connection pipe 32.Also, to the heat exchange vessel 14, a heat radiation part 28 of each heat pipe 24 is thermally connected.", "The treatment vessel 16 has a cylindrical shape corresponding to the casing 12 and forms the treatment chamber 48.The treatment vessel 16 would be suitably constituted by a member having high ultraviolet light transmittance and is formed of amorphous fluororesin or a glass material, such as quartz (SiO2).", "To the upstream side of the treatment vessel 16 is connected the connection pipe 32, and to the downstream side of the treatment vessel 16 is connected the discharge pipe 34.Also, outside the treatment vessel 16, the light emitting elements 20 are provided so as to surround the treatment vessel 16.Each light emitting element 20 is an light emitting diode (LED) that emits ultraviolet light of which the center wavelength or peak wavelength falls within a range of about 200 nm to 350 nm.", "The light emitting elements 20 may suitably be LEDs that emit ultraviolet light of which the wavelength falls within a range of about 260 nm to 270 nm, which has high sterilization efficiency.", "As such an ultraviolet LED, one using aluminum gallium nitride (AlGaN) is known, for example.", "A plurality of the light emitting elements 20 are mounted on a substrate 22 provided outside the treatment vessel 16 and are disposed to face the direction of ultraviolet light emission toward a fluid within the treatment chamber 48.As shown in FIG.", "1, each substrate 22 extends in a vertical direction (z-direction) along an outer wall of the treatment vessel 16, and a plurality of the light emitting elements 20 are mounted on the substrate 22 so as to be aligned in a z-direction.", "Also, the substrates 22, on each of which a plurality of the light emitting elements 20 are mounted, are disposed around the treatment vessel 16 at different positions in a circumferential direction, as shown in FIG.", "2.For example, the substrates 22 may be disposed at six positions that each are shifted from another by 60 degrees in a circumferential direction.", "Accordingly, the light emitting elements 20 are set to emit ultraviolet light equally over the entire treatment chamber 48.Each substrate 22 would be suitably constituted by a member having high thermal conductivity, and copper or aluminum may be used as a base material thereof, for example.", "To each substrate 22, an endothermic part 26 of a heat pipe 24 is connected.", "Accordingly, heat generated during the light emission of the light emitting elements 20 is transmitted to the heat pipes 24 via the substrates 22.Each heat pipe 24 is a metal pipe having a hollow structure, and a volatile heat medium is sealed therein.", "Each heat pipe 24 includes the endothermic part 26 and the heat radiation part 28, and it absorbs heat when the heat medium therein evaporates near the endothermic part 26 and radiates heat when the heat medium therein condenses near the heat radiation part 28.Each heat pipe 24 is disposed so that the endothermic part 26 is located on the vertically lower side and the heat radiation part 28 is located on the vertically upper side, and the endothermic part 26 is thermally connected to a substrate 22, and the heat radiation part 28 is thermally connected to the outer wall of the heat exchange vessel 14.In the inflow pipe 30, the inflow valve 40 is provided.", "When the inflow valve 40 is opened, a fluid to be sterilized flows into the heat exchange chamber 46.In the connection pipe 32, the gate valve 42 is provided.", "When the gate valve 42 is opened, the fluid to be sterilized is transferred from the heat exchange chamber 46 to the treatment chamber 48.Also, in the discharge pipe 34, the discharge valve 44 is provided.", "When the discharge valve 44 is closed, the fluid to be sterilized is stored in the treatment chamber 48.After the sterilization treatment is performed in the treatment chamber 48, by opening the discharge valve 44, the sterilized fluid flows out through the discharge pipe 34.The control device 50 controls the operations of the light emitting elements 20, inflow valve 40, gate valve 42, and discharge valve 44.The control device 50 opens the inflow valve 40 and the gate valve 42 to allow a fluid to be sterilized to flow into the heat exchange chamber 46 and the treatment chamber 48.The control device 50 closes the gate valve 42 and the discharge valve 44 to store a fluid to be sterilized in the treatment chamber 48 and also store a fluid used for water cooling in the heat exchange chamber 46.Also, the control device 50 opens the discharge valve 44 while keeping the gate valve 42 closed so as to allow only a fluid sterilized in the treatment chamber 48 to flow outside.", "FIG.", "3 is a flowchart that shows an operational process of the sterilization device 10.First, the discharge valve 44 is closed (S10) and the inflow valve 40 and the gate valve 42 are opened (S12) so as to allow a fluid to be sterilized to flow into the heat exchange chamber 46 and the treatment chamber 48.The completion of the inflow of the fluid to the heat exchange chamber 46 and the treatment chamber 48 is waited (N at S14) and, when the inflow is completed (Y at S14), the inflow valve 40 and the gate valve 42 are closed (S16), and the light emitting elements 20 are turned on to start irradiation of ultraviolet light (S18).", "The irradiation of ultraviolet light is continued until the sterilization treatment is completed (N at S22), and, when a period of time required for completion of the sterilization treatment has elapsed (Y at S22), the light emitting elements 20 are turned off to terminate the irradiation of ultraviolet light (S22).", "Thereafter, timing for discharging the sterilized fluid from the treatment chamber 48 is waited (N at S24), and, at the timing therefor (Y at S24), the discharge valve 44 is opened to discharge the sterilized fluid (S26).", "If continuous treatment is necessary (Y at S28), the process of S10 through S26 will be repeated, and, if continuous treatment is unnecessary (N at S28), the process of this flowchart will be terminated.", "According to the present embodiment, since the light emitting elements 20 are thermally connected to the heat exchange chamber 46 via the heat pipes 24, the light emitting elements 20 can be subjected to water cooling using the fluid stored in the heat exchange chamber 46.Since the fluid stored in the heat exchange chamber 46 is exchanged when the fluid is made to flow into the treatment chamber 48, a circulation passage for water cooling or a pump for circulating cooling water need not be newly provided.", "Therefore, according to the present embodiment, a sufficient cooling effect can be obtained using a water-cooling system, of which a means for cooling the light source can be simplified.", "According to the present embodiment, since the treatment chamber 48 used for ultraviolet light irradiation and the heat exchange chamber 46 used for cooling are separately provided, a sufficient cooling effect can be obtained with a simple structure.", "Since the wall surfaces of the treatment chamber 48 are formed of fluororesin, silica glass, or the like for transmitting ultraviolet light and have low thermal conductivity, heat radiation through the wall surfaces of the treatment chamber 48 is difficult.", "The treatment chamber 48 could be used as a heat exchange chamber by providing a heat sink within the treatment chamber 48 or by disposing the light source within the treatment chamber 48; however, if such a configuration is employed, a complicated structure will be required to make the treatment chamber 48 watertight.", "Meanwhile, according to the present embodiment, since the light source is disposed outside the treatment chamber 48, a watertight structure can be easily obtained only by preparing a vessel made of a material for transmitting ultraviolet light, and a water-cooling effect can be obtained using the heat exchange chamber 46 with a simple structure.", "According to the present embodiment, since the gate valve 42 is provided between the heat exchange chamber 46 and the treatment chamber 48, only a fluid sterilized in the treatment chamber 48 can be discharged.", "If the gate valve 42 is not provided, a fluid stored in the heat exchange chamber 46, which has not been irradiated with ultraviolet light, may be discharged together with the sterilized fluid.", "In the present embodiment, however, since the heat exchange chamber 46 and the treatment chamber 48 are separated by the gate valve 42, only a fluid that has been sufficiently sterilized in the treatment chamber 48 can be discharged, so that the sterilization effect on the discharged fluid can be improved.", "According to the present embodiment, by employing copper, having high thermal conductivity, as the material of the wall surfaces of the heat exchange chamber 46, a sterilization effect of copper ions can be obtained.", "Therefore, according to the present embodiment, the sterilization effect of copper ions and the sterilization effect of ultraviolet light irradiation can be combined, so that the sterilization capability can be improved.", "The present invention has been described with reference to the embodiment.", "It should be understood by those skilled in the art that the invention is not limited to the above-described embodiment and that various modifications could be developed on the basis of various design modifications and such modifications also fall within the scope of the present invention.", "In a modification, the inflow valve 40 need not necessarily be provided.", "In a modification, an additional cooling device may be provided for the heat exchange vessel 14.For example, a Peltier device or a fan for air cooling may be added to the heat exchange vessel 14.In a modification, the sterilization device may be used for purification treatment for decomposing an organic substance included in a fluid by irradiation of ultraviolet light.", "It should be understood that the invention is not limited to the above-described embodiment, but may be modified into various forms on the basis of the spirit of the invention.", "Additionally, the modifications are included in the scope of the invention." ] ]
Patent_15872818
[ [ "METHOD AND APPARATUS FOR TRANSRECEIVING DOWNLINK SIGNAL BY CONSIDERING ANTENNA PORT RELATIONSHIP IN WIRELESS COMMUNICATION SYSTEM", "The present invention relates to a wireless communication system, and more specifically, disclosed are a method and an apparatus for transmitting or receiving a downlink signal by considering an antenna port relationship.", "A method for user equipment receiving a physical downlink shared channel (PDSCH) signal in the wireless communication system, according to one embodiment of the present invention, comprises the steps of: determining a start symbol index of the PDSCH from a downlink subframe; and receiving the PDSCH signal based on the start symbol index, wherein the PDSCH can be scheduled by means of downlink control information (DCI) which is received through a physical downlink control channel (PDCCH) or an enhanced PDCCH (EPDCCH).", "When the DCI is comprised according to DCI format 1A, which is transmitted through the EPDDCH, and the downlink subframe is a non-multicast broadcast single frequency network (MBSFN) subframe, the start symbol index can be determined depending on an EPDCCH start symbol value which is established by an upper layer." ], [ "1.-8.", "(canceled) 9.A method for receiving a physical downlink shared channel (PDSCH) signal by a user equipment (UE) in a wireless communication system supporting a coordinated multi-point (CoMP) operation, the method comprising: receiving one or more PDSCH resource element mapping and Quasi co-location Indicator (PQI) parameter sets each including a PDSCH starting symbol parameter, a zero-power channel state information-reference signal (ZP CSI-RS) parameter and a non-zero power channel state information-reference signal (NZP CSI-RS) parameter; receiving information for configuring one or more enhanced physical downlink control channel (EPDCCH) sets; receiving, through an EPDCCH, downlink control information (DCI) scheduling a PDSCH based on the one or more EPDCCH sets; and obtaining data from the PDSCH, wherein each of the one or more PQI parameter sets including the PDSCH starting symbol parameter, ZP CSI-RS parameter and the NZP CSI-RS parameter is mapped to each of the one or more EPDCCH sets, and wherein when the DCI is configured according to DCI format 1A, and the downlink subframe is not a Multicast Broadcast Single Frequency Network (MBSFN) subframe, the UE determines a start symbol index for the PDSCH to be identical to an EPDCCH start symbol value for the EPDCCH, and wherein the EPDCCH start symbol value for the EPDCCH is determined from a PDSCH starting symbol parameter of a PQI parameter set that is mapped to an EPDCCH set where the EPDCCH is detected.", "10.The method according to claim 1, wherein when the DCI is not configured according to DCI format 1A, the UE determines the start symbol index for the PDSCH based on a PDSCH starting symbol parameter of a PQI parameter set indicated by the DCI.", "11.The method according to claim 1, wherein the PDSCH and the EPDCCH are received in a same serving cell.", "12.The method according to claim 1, wherein when the DCI is configured according to DCI format 1A, and the downlink subframe is the MBSFN subframe, the UE determines the start symbol index for the PDSCH by selecting a smaller one between a PDSCH starting symbol parameter of a lowest indexed PQI parameter set and a predetermined threshold.", "13.The method according to claim 1, wherein the PDSCH is received based on a cell-specific reference signal (CRS).", "14.The method according to claim 1, wherein the UE is set to transmission mode 10 (TM10).", "15.The method according to claim 1, wherein the start symbol index indicates a start Orthogonal Frequency Division Multiplexing (OFDM) symbol from which the PDSCH is mapped in the downlink subframe.", "16.A user equipment (UE) for receiving a physical downlink shared channel (PDSCH) signal in a wireless communication system supporting a coordinated multi-point (CoMP) operation, the UE comprising: a receiver; and a processor controls the receiver to receive one or more PDSCH resource element mapping and Quasi co-location Indicator (PQI) parameter sets each including a PDSCH starting symbol parameter, a zero-power channel state information-reference signal (ZP CSI-RS) parameter and a non-zero power channel state information-reference signal (NZP CSI-RS) parameter, to receive information for configuring one or more enhanced physical downlink control channel (EPDCCH) sets and to receive, through an EPDCCH, downlink control information (DCI) scheduling a PDSCH based on the one or more EPDCCH sets, and to obtain data from the PDSCH, wherein each of the one or more PQI parameter sets including the PDSCH starting symbol parameter, ZP CSI-RS parameter and the NZP CSI-RS parameter is mapped to each of the one or more EPDCCH sets, and wherein when the DCI is configured according to DCI format 1A, and the downlink subframe is not a Multicast Broadcast Single Frequency Network (MBSFN) subframe, the processor determines a start symbol index for the PDSCH to be identical to an EPDCCH start symbol value for the EPDCCH, and wherein the EPDCCH start symbol value for the EPDCCH is determined from a PDSCH starting symbol parameter of a PQI parameter set that is mapped to an EPDCCH set where the EPDCCH is detected.", "17.The UE according to claim 8, wherein when the DCI is not configured according to DCI format 1A, and the downlink subframe is not the MBSFN subframe, the UE determines the start symbol index for the PDSCH based on a PDSCH starting symbol parameter of a PQI parameter set indicated by the DCI.", "18.The UE according to claim 8, wherein the PDSCH and the EPDCCH are received in a same serving cell.", "19.The UE according to claim 8, wherein when the DCI is configured according to DCI format 1A, the UE determines the start symbol index for the PDSCH by selecting a smaller one between a PDSCH starting symbol parameter of a lowest indexed PQI parameter set and a predetermined threshold.", "20.The UE according to claim 8, wherein the PDSCH is received based on a cell-specific reference signal (CRS).", "21.The UE according to claim 8, wherein the UE is set to transmission mode 10 (TM10).", "22.The UE according to claim 8, wherein the start symbol index indicates a start Orthogonal Frequency Division Multiplexing (OFDM) symbol from which the PDSCH is mapped in the downlink subframe." ], [ "<SOH> BACKGROUND ART <EOH>Multiple-Input Multiple-Output (MIMO) technology is a technology for improving efficiency of data transmission and reception using multiple transmit antennas and multiple receive antennas rather than using one transmit antenna and one receive antenna.", "If a single antenna is used, a receive entity receives data through a single antenna path.", "In contrast, if multiple antennas are used, the receive entity receives data through several paths, accordingly data transmission rate and throughput may be improved, and the coverage may be extended.", "To increase multiplexing gain of the MIMO operation, an MIMO transmit entity may use channel state information (CSI) fed back by the MIMO receive entity.", "The receive entity may determine the CSI by performing channel measurement using a predetermined reference signal (RS) from the transmit entity." ], [ "TECHNICAL FIELD The present invention relates to a wireless communication system, and more particularly, to a method and apparatus for transmitting or receiving a downlink signal by considering an antenna port relationship.", "BACKGROUND ART Multiple-Input Multiple-Output (MIMO) technology is a technology for improving efficiency of data transmission and reception using multiple transmit antennas and multiple receive antennas rather than using one transmit antenna and one receive antenna.", "If a single antenna is used, a receive entity receives data through a single antenna path.", "In contrast, if multiple antennas are used, the receive entity receives data through several paths, accordingly data transmission rate and throughput may be improved, and the coverage may be extended.", "To increase multiplexing gain of the MIMO operation, an MIMO transmit entity may use channel state information (CSI) fed back by the MIMO receive entity.", "The receive entity may determine the CSI by performing channel measurement using a predetermined reference signal (RS) from the transmit entity.", "DISCLOSURE Technical Problem In an advanced wireless communication system, a relationship between different antenna ports may be defined in various manners.", "For example, a terminal may assume that different RS ports of a network are quasi co-located (QCL) or that that the RS ports are not QCL, without asking whether the different RS ports are present at the same location.", "An object of the present invention devised to solve the problem lies in a method for a terminal to accurately and efficiently receive a downlink signal transmitted from the network side by considering a relationship (particularly, a QCL relationship) between antenna ports.", "It is to be understood that technical objects to be achieved by the present invention are not limited to the aforementioned technical objects and other technical objects which are not mentioned herein will be apparent from the following description to one of ordinary skill in the art to which the present invention pertains.", "Technical Solution The object of the present invention can be achieved by providing a method for receiving a physical downlink shared channel (PDSCH) signal by a user equipment (UE) in a wireless communication system, the method including determining a start symbol index of the PDSCH in a downlink subframe, and receiving the PDSCH signal based on the start symbol index.", "Herein, the PDSCH may be scheduled by downlink control information (DCI) received through a physical downlink control channel (PDCCH) or an enhanced PDCCH (EPDCCH).", "When the DCI is configured according to DCI format 1A transmitted through the EPDCCH, and the downlink subframe is a non-Multicast Broadcast Single Frequency Network (MBSFN) subframe, the start symbol index may be determined according to an EPDCCH start symbol value.", "In another aspect of the present invention, provided herein is a user equipment (UE) for receiving a physical downlink shared channel (PDSCH) signal in a wireless communication system, the UE including a transmit module, a receive module, and a processor.", "The processor may be configured to determine a start symbol index of the PDSCH in a downlink subframe and to receive the PDSCH signal based on the start symbol index using the receive module.", "Herein, the PDSCH is scheduled by downlink control information (DCI) received through a physical downlink control channel (PDCCH) or an enhanced PDCCH (EPDCCH).", "When the DCI is configured according to DCI format 1A transmitted through the EPDCCH, and the downlink subframe is a non-Multicast Broadcast Single Frequency Network (MBSFN) subframe, the start symbol index may be determined according to an EPDCCH start symbol value.", "The above aspects of the present invention may include the following details in common.", "The EPDCCH start symbol value may be set with respect to an EPDCCH set, the EPDCCH being received in the EPDCCH set.", "When the DCI is configured according to DCI format 1A transmitted through the PDCCH, and the downlink subframe is a non-MBSFN subframe, the start symbol index may be determined according to a control format indicator (CFI) value.", "The PDSCH may be received through antenna port 0 of a serving cell or received in a transmit diversity mode, wherein the PDCCH may be received from the serving cell.", "The PDSCH may be received based on a cell-specific reference signal (CRS).", "The UE may be set to transmission mode 10 (TM10).", "The start symbol index may indicate a start OFDM (Orthogonal Frequency Division Multiplexing) symbol, the PDSCH being mapped to the start OFDM symbol in the downlink subframe.", "The above general description and the following detailed description of the present invention are exemplarily given to supplement the recitations in the claims.", "Advantageous Effects According to embodiments of the present invention, a terminal may accurately and efficiently receive a downlink signal transmitted from the network side by considering a relationship (particularly, a QCL relationship) between antenna ports.", "It will be appreciated by those skilled in the art that the effects that can be achieved with the present invention are not limited to what has been described above and other advantages of the present invention will be clearly understood from the following detailed description taken in conjunction with the accompanying drawings.", "DESCRIPTION OF DRAWINGS The accompanying drawings, which are included to provide a further understanding of the invention, illustrate embodiments of the invention and together with the description serve to explain the principle of the invention.", "In the drawings: FIGS.", "1(a) and 1(b) illustrate a radio frame structure; FIG.", "2 is a diagram illustrating a resource grid for one downlink (DL) slot; FIG.", "3 is a diagram illustrating a DL subframe structure; FIG.", "4 is a diagram illustrating an uplink (UL) subframe structure; FIGS.", "5(a) and 5(b) illustrate a configuration of a wireless communication system having multiple antennas; FIG.", "6 is a diagram illustrating an exemplary pattern of a CRS and a DRS on one RB pair; FIG.", "7 is a diagram illustrating an exemplary DMRS pattern defined in LTE-A; FIGS.", "8(a)-8(e) are diagrams illustrating exemplary CSI-RS patterns defined in LTE-A; FIG.", "9 is a diagram illustrating an exemplary scheme in which a CSI-RS is periodically transmitted; FIGS.", "10(a) and 10(b) illustrate carrier aggregation; FIG.", "11 is a diagram illustrating cross-carrier scheduling; FIG.", "12 is a flowchart illustrating a method for transmitting and receiving a PDSCH signal according to one embodiment of the present invention; FIG.", "13 is a diagram illustrating configurations of a base station and a user equipment.", "BEST MODE The embodiments described below are constructed by combining elements and features of the present invention in a predetermined form.", "The elements or features may be considered selective unless explicitly mentioned otherwise.", "Each of the elements or features can be implemented without being combined with other elements.", "In addition, some elements and/or features may be combined to configure an embodiment of the present invention.", "The sequence of the operations discussed in the embodiments of the present invention may be changed.", "Some elements or features of one embodiment may also be included in another embodiment, or may be replaced by corresponding elements or features of another embodiment.", "Embodiments of the present invention will be described focusing on a data communication relationship between a base station and a terminal.", "The base station serves as a terminal node of a network over which the base station directly communicates with the terminal.", "Specific operations illustrated as being conducted by the base station in this specification may be conducted by an upper node of the base station, as necessary.", "In other words, it will be obvious that various operations allowing for communication with the terminal in a network composed of several network nodes including the base station can be conducted by the base station or network nodes other than the base station.", "The term “base station (BS)” may be replaced with terms such as “fixed station,” “Node-B,” “eNode-B (eNB),” and “access point (AP),” “remote radio head (RRD),” “transmission point (TP),” and “reception point (RP).” The term “relay” may be replaced with terms such as “relay node (RN)” and “relay station (RS)”.", "The term “terminal” may also be replaced with such terms as “user equipment (UE),” “mobile station (MS),” “mobile subscriber station (MSS)” and “subscriber station (SS).” It should be noted that specific terms disclosed in the present invention are proposed for convenience of description and better understanding of the present invention, and these specific terms may be changed to other formats within the technical scope or spirit of the present invention.", "In some cases, known structures and devices may be omitted or block diagrams illustrating only key functions of the structures and devices may be provided, so as not to obscure the concept of the present invention.", "The same reference numbers will be used throughout this specification to refer to the same or like parts.", "Exemplary embodiments of the present invention are supported by standard documents for at least one of wireless access systems including an institute of electrical and electronics engineers (IEEE) 802 system, a 3rd generation partnership project (3GPP) system, a 3GPP long term evolution (LTE) system, an LTE-advanced (LTE-A) system, and a 3GPP2 system.", "In particular, steps or parts, which are not described in the embodiments of the present invention to prevent obscuring the technical spirit of the present invention, may be supported by the above documents.", "All terms used herein may be supported by the above-mentioned documents.", "The embodiments of the present invention described below can be applied to a variety of wireless access technologies such as code division multiple access (CDMA), frequency division multiple access (FDMA), time division multiple access (TDMA), orthogonal frequency division multiple access (OFDMA), and single carrier frequency division multiple access (SC-FDMA).", "CDMA may be embodied through wireless technologies such as universal terrestrial radio access (UTRA) or CDMA2000.TDMA may be embodied through wireless technologies such as global system for mobile communication (GSM)/general packet radio service (GPRS)/enhanced data rates for GSM evolution (EDGE).", "OFDMA may be embodied through wireless technologies such as IEEE 802.11 (Wi-Fi), IEEE 802.16 (WiMAX), IEEE 802-20, and evolved UTRA (E-UTRA).", "UTRA is a part of universal mobile telecommunications system (UMTS).", "3rd generation partnership project (3GPP) long term evolution (LTE) is a part of evolved UMTS (E-UMTS), which uses E-UTRA.", "3GPP LTE employs OFDMA for downlink and employs SC-FDMA for uplink.", "LTE-Advanced (LTE-A) is an evolved version of 3GPP LTE.", "WiMAX can be explained by IEEE 802.16e (wirelessMAN-OFDMA reference system) and IEEE 802.16m advanced (wirelessMAN-OFDMA advanced system).", "For clarity, the following description focuses on 3GPP LTE and 3GPP LTE-A systems.", "However, the spirit of the present invention is not limited thereto.", "FIG.", "1 illustrates a radio frame structure.", "In a cellular OFDM wireless packet communication system, an uplink (UL)/downlink (DL) data packet is transmitted on a subframe-by-subframe basis, and one subframe is defined as a predetermined time interval including a plurality of OFDM symbols.", "3GPP LTE supports a type-1 radio frame structure applicable to frequency division duplex (FDD) and a type-2 radio frame structure applicable to time division duplex (TDD).", "FIG.", "1(a) illustrates the type-1 radio frame structure.", "A downlink radio frame is divided into ten subframes.", "Each subframe includes two slots in the time domain.", "The time taken to transmit one subframe is defined as a transmission time interval (TTI).", "For example, a subframe may have a duration of 1 ms and one slot may have a duration of 0.5 ms. A slot may include a plurality of OFDM symbols in the time domain and a plurality of resource blocks (RBs) in the frequency domain.", "Since 3GPP LTE employs OFDMA for downlink, an OFDM symbol represents one symbol period.", "An OFDM symbol may be referred to as an SC-FDMA symbol or a symbol period.", "A resource block (RB), which is a resource allocation unit, may include a plurality of consecutive subcarriers in a slot.", "The number of OFDM symbols included in one slot depends on the configuration of a cyclic prefix (CP).", "CPs are divided into an extended CP and a normal CP.", "For a normal CP configuring each OFDM symbol, a slot may include 7 OFDM symbols.", "For an extended CP configuring each OFDM symbol, the duration of each OFDM symbol is extended and thus the number of OFDM symbols included in a slot is smaller than in the case of the normal CP.", "For the extended CP, a slot may include, for example, 6 OFDM symbols.", "When a channel status is unstable as in the case of high speed movement of a UE, the extended CP may be used to reduce inter-symbol interference.", "When the normal CP is used, each slot includes 7 OFDM symbols, and thus each subframe includes 14 OFDM symbols.", "In this case, the first two or three OFDM symbols of each subframe may be allocated to a physical downlink control channel (PDCCH) and the other three OFDM symbols may be allocated to a physical downlink shared channel (PDSCH).", "FIG.", "1(b) illustrates the type-2 radio frame structure.", "The type-2 radio frame includes two half frames, each of which includes 5 subframes, a downlink pilot time slot (DwPTS), a guard period (GP), and an uplink pilot time slot (UpPTS).", "One subframe includes two slots.", "A subframe including a DwPTS, a GP and a UpPTS may be referred to as a special subframe.", "The DwPTS is used for initial cell search, synchronization, or channel estimation in a UE, whereas the UpPTS is used for channel estimation in an eNB and UL transmission synchronization in a UE.", "The GP is provided to eliminate interference on UL caused by multipath delay of a DL signal between DL and UL.", "Regardless of the type of a radio frame, a subframe of the radio frame includes two slots.", "The illustrated radio frame structures are merely examples, and various modifications may be made to the number of subframes included in a radio frame, the number of slots included in a subframe, or the number of symbols included in a slot.", "FIG.", "2 is a diagram illustrating a resource grid for one DL slot.", "A DL slot includes 7 OFDM symbols in the time domain and an RB includes 12 subcarriers in the frequency domain.", "However, embodiments of the present invention are not limited thereto.", "For a normal CP, a slot may include 7 OFDM symbols.", "For an extended CP, a slot may include 6 OFDM symbols.", "Each element in the resource grid is referred to as a resource element (RE).", "An RB includes 12×7 REs.", "The number NDL of RBs included in a downlink slot depends on a DL transmission bandwidth.", "A UL slot may have the same structure as a DL slot.", "FIG.", "3 illustrates a DL subframe structure.", "Up to first three OFDM symbols of the first slot in a DL subframe correspond to a control region to which control channels are allocated and the other OFDM symbols of the DL subframe corresponds to a data region to which a physical downlink shared channel (PDSCH) is allocated.", "DL control channels used in 3GPP LTE include, for example, a physical control format indicator channel (PCFICH), a physical downlink control channel (PDCCH), and a physical hybrid automatic repeat request (HARQ) indicator channel (PHICH).", "The PCFICH is transmitted in the first OFDM symbol of a subframe, carrying information about the number of OFDM symbols used for transmission of control channels in the subframe.", "The PHICH carries a HARQ ACK/NACK signal in response to uplink transmission.", "Control information carried on the PDCCH is called downlink control information (DCI).", "The DCI includes UL or DL scheduling information or UL transmit power control commands for UE groups.", "The PDCCH delivers information about resource allocation and a transport format for a DL shared channel (DL-SCH), resource allocation information about a UL shared channel (UL-SCH), paging information of a paging channel (PCH), system information on the DL-SCH, information about resource allocation for a higher-layer control message such as a random access response transmitted on the PDSCH, a set of transmit power control commands for individual UEs of a UE group, transmit power control information, and voice over internet protocol (VoIP) activation information.", "A plurality of PDCCHs may be transmitted in the control region, and a UE may monitor PDCCHs.", "A PDCCH is formed by aggregating one or more consecutive control channel elements (CCEs).", "A CCE is a logical allocation unit used to provide a PDCCH at a coding rate based on the state of a radio channel.", "A CCE corresponds to a plurality of RE groups.", "The format of a PDCCH and the number of available bits for the PDCCH are determined depending on the correlation between the number of CCEs and a coding rate provided by the CCEs.", "An eNB determines the PDCCH format according to DCI transmitted to a UE and adds a cyclic redundancy check (CRC) to the control information.", "The CRC is masked by an identifier (ID) known as a radio network temporary identifier (RNTI) according to the owner or usage of the PDCCH.", "If the PDCCH is directed to a specific UE, its CRC may be masked by a cell-RNTI (C-RNTI) of the UE.", "If the PDCCH is for a paging message, the CRC of the PDCCH may be masked by a paging radio network temporary identifier (P-RNTI).", "If the PDCCH delivers system information, particularly, a system information block (SIB), the CRC thereof may be masked by a system information ID and a system information RNTI (SI-RNTI).", "To indicate that the PDCCH delivers a random access response in response to a random access preamble transmitted by a UE, the CRC thereof may be masked by a random access-RNTI (RA-RNTI).", "FIG.", "4 illustrates a UL subframe structure.", "A UL subframe may be divided into a control region and a data region in the frequency domain.", "A physical uplink control channel (PUCCH) carrying uplink control information is allocated to the control region and a physical uplink shared channel (PUSCH) carrying user data is allocated to the data region.", "To maintain a single carrier property, a UE does not simultaneously transmit a PUSCH and a PUCCH.", "A PUCCH for a UE is allocated to an RB pair in a subframe.", "The RBs of the RB pair occupy different subcarriers in two slots.", "This is called frequency hopping of the RB pair allocated to the PUCCH over a slot boundary.", "Modeling of MIMO System FIG.", "5 illustrates configuration of a wireless communication system having multiple antennas.", "Referring to FIG.", "5(a), if the number of transmit (Tx) antennas increases to NT, and the number of receive (Rx) antennas increases to NR, a theoretical channel transmission capacity of the wireless communication system increases in proportion to the number of antennas, differently from a case in which only a transmitter or receiver uses multiple antennas, and accordingly transmission rate and frequency efficiency may be significantly increased.", "In this case, the transfer rate acquired by the increasing channel transmission capacity may theoretically increased by a predetermined amount that corresponds to multiplication of a maximum transfer rate (Ro) acquired when one antenna is used by a rate of increase (Ri).", "The rate of increase (Ri) may be represented by the following Equation 1.Ri=min(NT,NR) Equation For example, provided that a MIMO system uses four Tx antennas and four Rx antennas, the MIMO system may theoretically acquire a high transfer rate which is four times that of a single antenna system.", "After the above-mentioned theoretical capacity increase of the MIMO system was demonstrated in the mid-1990s, many developers began to conduct intensive research into a variety of technologies which may substantially increase data transfer rate using the theoretical capacity increase.", "Some of the above technologies have been reflected in a variety of wireless communication standards such as, for example, third-generation mobile communication and next-generation wireless LAN.", "A variety of MIMO-associated technologies have been intensively researched.", "For example, research into information theory associated with MIMO communication capacity under various channel environments or multiple access environments, research into a radio frequency (RF) channel measurement and modeling of the MIMO system, and research into space-time signal processing technology have been conducted.", "Mathematical modeling of a communication method for use in the aforementioned MIMO system will hereinafter be described in detail.", "It is assumed that the system includes NT Tx antennas and NR Rx antennas.", "In the case of a transmission signal, the maximum number of pieces of transmittable information is NT under the condition that NT Tx antennas are used, and the transmission information may be represented by the following equation.", "s=└s1,s2, .", ".", ".", ",sNT┘T Equation 2 Individual transmission pieces of information s1, s2, .", ".", ".", ", sNT may have different transmit powers.", "In this case, if the individual transmit powers are denoted by P1, P2, .", ".", ".", ", PNT, transmission information having an adjusted transmit power may be represented by the following equation.", "ŝ=[ŝ1,ŝ2, .", ".", ".", ",ŝNT]T=[P1s1,P2s2, .", ".", ".", ",PNTsNT]T Equation 3 Ŝ may be represented by the following equation using a diagonal matrix P of transmit powers.", "s ^ = [ P 1 0 P 2 ⋱ 0 P N T ]  [ s 1 s 2 ⋮ s N T ] = Ps Equation   4 The information vector Ŝ having adjusted transmit powers is applied to a weight matrix W, and thus NT transmission signals x1, x2, .", ".", ".", ", xNT to be actually transmitted are configured.", "In this case, the weight matrix W serves to properly distribute transmission information to individual antennas according to transmission channel situations.", "The above-mentioned transmission signals x1, x2, .", ".", ".", ", xNT may be represented by the following equation using vector X. x = [ x 1 x 2 ⋮ x i ⋮ x N T ] = [ w 11 w 12 … w 1  N T w 21 w 22 … w 2  N T ⋮ ⋱ w i   1 w i   2 … w iN T ⋮ ⋱ w N T  1 w N T  2 … w N T  N T ]  [ s ^ 1 s ^ 2 ⋮ s ^ j ⋮ s ^ N T ] = W  s ^ = WPs Equation   5 Here, Wij denotes a weight corresponding to the i-th Tx antenna and the j-th information.", "W is also called a precoding matrix.", "When NR Rx antennas are used, received signals y1, y2, .", ".", ".", ".", ", yNR of individual antennas may be represented by a vector shown in the following equation.", "y=[y1,y2, .", ".", ".", ",yNR]T Equation 6 When channel modeling is executed in the MIMO communication system, individual channels may be distinguished from each other according to Tx/Rx antenna indexes.", "A specific channel from a Tx antenna j to an Rx antenna i is denoted by hij.", "Regarding hij, it should be noted that an Rx antenna index is located ahead of a Tx antenna index.", "FIG.", "5(b) shows channels from NT Tx antennas to Rx antenna i.", "The channels may be represented in the form of a vector or matrix.", "Referring to FIG.", "5(b), the channels from the NT Tx antennas to the Rx antenna i may be represented by the following equation.", "hiT=[hi1,hi2, .", ".", ".", ",hiNT] Equation 7 All channels from the NT Tx antennas to NR Rx antennas may also be represented as the following.", "H = [ h 1 T h 2 T ⋮ h i T ⋮ h N R T ] = [ h 11 h 12 … h 1  N T h 21 h 22 … h 2  N T ⋮ ⋱ h i   1 h i   2 … h iN T ⋮ ⋱ h N R  1 h N R  2 … h N R  N T ] Equation   8 Additive white Gaussian noise (AWGN) is added to an actual channel after application of channel matrix H. AWGN n1, n2, .", ".", ".", ", nNR added to each of NR Rx antennas may be represented by the following equation.", "n=[n1,n2, .", ".", ".", ",nNR]T Equation 9 Reception signal calculated by the mathematical modeling described above may be represented by the following equation.", "y = [ y 1 y 2 ⋮ y i ⋮ y N R ] = [ h 11 h 12 … h 1  N T h 21 h 22 … h 2  N T ⋮ ⋱ h i   1 h i   2 … h iN T ⋮ ⋱ h N R  1 h N R  2 … h N R  N T ]  [ x 1 x 2 ⋮ x j ⋮ x N T ] + [ n 1 n 2 ⋮ n i ⋮ n N R ] = Hx + n Equation   10 The number of rows and the number of columns of channel matrix H indicating a channel condition are determined by the number of Tx/Rx antennas.", "In the channel matrix H, the number of rows is equal to the number (NR) of Rx antennas, and the number of columns is equal to the number (NT) of Tx antennas.", "Namely, the channel matrix H is denoted by an NR×NT matrix.", "A rank of a matrix is defined by a smaller number between the number of rows and the number of columns, in which the rows and the columns are independent of each other.", "Therefore, the matrix rank may not be higher than the number of rows or columns.", "The rank of the channel matrix H may be represented by the following equation.", "rank(H)≤min(NT,NR) Equation 11 The rank may be defined as the number of non-zero Eigen values when Eigen value decomposition is performed on the matrix.", "Similarly, the rank may be defined as the number of non-zero singular values when singular value decomposition is performed on the matrix.", "Accordingly, the rank of the channel matrix refers to a maximum number of pieces of information that may be transmitted on a given channel.", "In this specification, “rank” with respect to MIMO transmission indicates the number of paths through which signals may be independently transmitted at specific time in a specific frequency resource and “the number of layers” refers to the number of signal streams transmitted through each path.", "Since a transmitter transmits as many layers as the rank used in signal transmission, the rank corresponds to the number of layers unless otherwise mentioned.", "Reference Signal (RS) In transmitting packets in a wireless communication system, the packets are transmitted over a radio channel, and therefore signal distortion may occur in the transmission process.", "For a receive entity to receive the correct signal in spite of signal distortion, the received distorted signal should be corrected using channel information.", "In detecting the channel information, a signal which is known to both the transmit entity and the receive entity is usually transmitted and the degree of distortion of the signal received over the channel is used to detect the channel information.", "This signal is referred to as a pilot signal or a reference signal.", "When data is transmitted and received using multiple antennas, channel state between each Tx antenna and each Rx antenna needs to be recognized in order to receive a correct signal.", "Accordingly, a separate reference signal needs to be present per Tx antenna.", "The RSs may be broadly divided into two types according to the purposes thereof.", "One type is used to acquire channel information and the other type is used for data demodulation.", "Since the former RS is used to allow the UE to acquire DL channel information, this RS should be transmitted over a wide band, and even a UE which does not receive DL data in a specific subframe should be receive and measure the RS.", "Such RS is also used for measurement of, for example, handover.", "The latter RS is sent when an eNB sends a resource on downlink.", "The UE may perform channel measurement by receiving this RS, thereby implementing data modulation.", "This RS should be transmitted in a region in which data is transmitted.", "Legacy 3GPP LTE systems (e.g., 3GPP LTE Release-8) define two types of downlink RSs for the unicast service.", "One is a common RS (CRS), and the other is a dedicated RS (DRS).", "The CRS is used for acquisition of information about the channel state and measurement of, for example, handover, and may be referred to as a cell-specific RS.", "The DRS is used for data demodulation, and may be referred to as a UE-specific RS.", "In the legacy 3GPP LTE systems, the DRS may be used only for data demodulation, and the CRS may be used for both acquisition of channel information and data demodulation.", "The CRS is transmitted cell-specifically in every subframe in a wideband.", "The CRS may be transmitted with respect to up to four antenna ports depending on the number of Tx antennas of the eNB.", "For example, if the number of Tx antennas of the eNB is 2, CRSs for antenna ports #0 and #1 are transmitted.", "If the number of Tx antennas of the eNB is 4, CRSs for antenna ports #0 to #3 are respectively transmitted.", "FIG.", "6 illustrates an exemplary pattern of a CRS and a DRS on one RB pair.", "Referring to FIG.", "6, the pattern of the CRS and the DRS is presented on one RB pair (14 OFDM symbols in the time domain×12 subcarriers in the frequency domain in the case of normal CP) in a system in which the eNB supports four transmit antennas.", "In FIG.", "6, resource elements (REs) denoted by “R0”, “R1”, “R2” and “R3” represent the locations of the CRSs for antenna port indexes 0, 1, 2 and 3, respectively.", "In FIG.", "6, REs denoted by “D” represent the locations of DRSs.", "LTE-A, which is an advanced version of LTE, can supports up to 8 Tx antennas on downlink.", "Accordingly, RSs for up to 8 Tx antennas need to be supported in LTE-A.", "In LTE, downlink RSs are defined only for up to 4 antenna ports.", "Therefore, if an eNB has 4 to 8 DL Tx antennas in LTE-A, RSs for these antenna ports need to be additionally defined.", "As the RSs for up to 8 Tx antenna ports, both the RS for channel measurement and the RS for data demodulation need to be considered.", "One important consideration in designing an LTE-A system is backward compatibility.", "Backward compatibility refers to supporting the legacy LTE UE such that the legacy LTE UE normally operates in the LTE-A system.", "In terms of RS transmission, if RSs for up to 8 Tx antennas are added to a time-frequency region in which a CRS defined in the LTE standard is transmitted in every subframe over the full band, RS overhead excessively increases.", "Accordingly, in designing new RSs for up to 8 antenna ports, reducing RS overhead needs to be considered.", "The new RSs introduced in LTE-A may be classified into two types.", "One is a channel state information-RS (CSI-RS) intended for channel measurement for selecting a transmission rank, a modulation and coding scheme (MCS), a precoding matrix index (PMI), and the like, and the other is a demodulation RS (DMRS) intended for demodulation of data transmitted through up to 8 Tx antennas.", "The CSI-RS intended for channel measurement is designed only for channel measurement, unlike the existing CRS, which is used for data demodulation as well as for channel measurement and handover measurement.", "Of course, the CSI-RS may also be used for handover measurement.", "Since the CSI-RS is transmitted only in order to obtain information about channel states, the CSI-RS need not be transmitted in every subframe, unlike the CRS for the legacy LTE system.", "Accordingly, to reduce overhead of the CSI-RS, the CSI-RS may be designed to be intermittently (e.g., periodically) transmitted in the time domain.", "When data is transmitted in a certain DL subframe, a dedicated DMRS is transmitted to a UE for which the data transmission is scheduled.", "That is, the DMRS may be referred to as a UE-specific RS.", "A DMRS dedicated to a specific UE may be designed to be transmitted only in a resource region in which the UE is scheduled, i.e., the time-frequency region in which data for the UE is transmitted.", "FIG.", "7 illustrates an exemplary DMRS pattern defined in LTE-A.", "FIG.", "7 shows positions of REs for transmission of DMRSs on one RB pair (14 OFDM symbols in the time domain×12 subcarriers in the frequency domain in the case of normal CP) on which downlink data is transmitted.", "The DMRS may be transmitted with respect to four antenna ports (antenna port indexes 7, 8, 9 and 10) which are additionally defined in LTE-A.", "DMRSs for different antenna ports may be distinguished from each other as they are positioned on different frequency resources (subcarriers) and/or different time resources (OFDM symbols) (namely, they may be multiplexed using FDM and/or TDM).", "DMRSs for different antenna ports positioned on the same time-frequency resource may be distinguished from each other by an orthogonal code (namely, they may be multiplexed using the CDM scheme).", "In the example of FIG.", "7.DMRSs for antenna ports 7 and 8 may be positioned on the REs indicated by DMRS CDM Group 1 and be multiplexed by an orthogonal code.", "Similarly, in the example of FIG.", "7, DMRSs for antenna ports 9 and 10 may be positioned on the REs indicated by DMRS Group 2 and be multiplexed by the orthogonal code.", "When the eNB transmits a DMRS, the precoding applied to data is applied to the DMRS.", "Accordingly, the channel information estimated by the UE using the DMRS (or UE-specific RS) is precoded channel information.", "The UE may easily perform data demodulation using the precoded channel information estimated through the DMRS.", "However, the UE does not know the information about the precoding applied to the DMRS, and accordingly the UE may not acquire, from the DMRS, channel information that is not precoded.", "The UE may acquire the channel information that is not precoded, using an RS separate from the DMRS, namely using the CSI-RS mentioned above.", "FIG.", "8 is a diagram illustrating exemplary CSI-RS patterns defined in LTE-A.", "FIG.", "8 shows positions of REs for transmission of CSI-RSs on one RB pair (14 OFDM symbols in the time domain×12 subcarriers in the frequency domain in the case of normal CP) on which downlink data is transmitted.", "One of CSI-RS patterns shown in FIGS.", "8(a) to 8(e) may be used in a DL subframe.", "CSI-RSs may be transmitted with respect to 8 antenna ports (antenna port indexes 15, 16, 17, 18, 19, 20, 21 and 22) which are additionally defined in LTE-A.", "CSI-RSs for different antenna ports may be distinguished from each other as they are positioned on different frequency resources (subcarriers) and/or different time resources (OFDM symbols) (namely, they may be multiplexed using FDM and/or TDM).", "CSI-RSs for different antenna ports positioned on the same time-frequency resource may be distinguished from each other by an orthogonal code (namely, they may be multiplexed using CDM).", "In the example of FIG.", "8(a), CSI-RSs for antenna ports 15 and 16 may be positioned on the REs indicated by CSI-RS CDM Group 1 and be multiplexed by an orthogonal code.", "In the example of FIG.", "8(a), CSI-RSs for antenna ports 17 and 18 may be positioned on the REs indicated by CSI-RS CDM Group 2 and be multiplexed by the orthogonal code.", "CSI-RSs for antenna ports 19 and 20 may be positioned on the REs indicated by CSI-RS CDM Group 3 and be multiplexed by the orthogonal code.", "In the example of FIG.", "8(a), CSI-RSs for antenna ports 21 and 22 may be positioned on the REs indicated by CSI-RS CDM Group 4 and multiplexed by the orthogonal code.", "The principle described above with reference to FIG.", "8(a) may also be applied to FIGS.", "8(b) to 8(e).", "The RS patterns of FIGS.", "6 to 8 are simply illustrative, and embodiments of the present invention are not limited to specific RS patterns.", "In other words, the embodiments of the present invention may be applied in the same manner when an RS pattern different from those of FIGS.", "6 to 8 is defined and used.", "CSI-RS Configuration As described above, in the LTE-A system supporting up to 8 Tx antennas on downlink, an eNB needs to transmit CSI-RSs for all antenna ports.", "Since transmitting CSI-RSs for a maximum of 8 Tx antenna ports in every subframe excessively increases overhead, the CSI-RS may need to be intermittently transmitted in the time domain to reduce overhead, rather than being transmitted in every subframe.", "Accordingly, the CSI-RS may be periodically transmitted with a periodicity corresponding to an integer multiple of one subframe or transmitted in a specific transmission pattern.", "Here, the periodicity or pattern in which the CSI-RS is transmitted may be configured by a network (e.g., an eNB).", "To perform CSI-RS-based measurement, the UE should be aware of a CSI-RS configuration for each CSI-RS antenna port of a cell (or a TP) to which the UE belongs.", "The CSI-RS configuration may include the index of a downlink subframe in which a CSI-RS is transmitted, time-frequency positions (e.g., a CSI-RS pattern as shown in FIGS.", "8(a) to 8(e)) of CSI-RS REs in a transmission subframe, and a CSI-RS sequence (which is a sequence intended for CSI-RS and pseudo-randomly generated based on the slot number, cell ID, CP length and the like according to a predetermined rule).", "That is, a given eNB may use a plurality of CSI-RS configurations, and inform of CSI-RS configurations to be used for UE(s) in a cell among the CSI-RS configurations.", "The plurality of CSI-RS configurations may or may not include a CSI-RS configuration for which the UE assumes that the transmit power of the CSI-RS is non-zero power.", "In addition, the plurality of CSI-RS configurations may or may not include at least one CSI-RS configuration for which the UE assumes that the transmit power of the CSI-RS is zero transmit power.", "Further, each bit of a parameter (e.g., a 16-bit bitmap ZeroPowerCSI-RS parameter) for a CSI-RS configuration of zero transmit power may be caused by a higher layer to correspond to the CSI-RS configuration (or REs to which CSI-RSs can be allocated according to the CSI-RS configuration), and the UE may assume that the transmit power on the CSI-RS REs of a CSI-RS configuration corresponding to a bit set to 1 in the parameter is 0.Since CSI-RSs for the respective antenna ports need to be distinguished from each other, resources on which the CSI-RSs for the antenna ports are transmitted need to be orthogonal to each other.", "As described above in relation to FIG.", "8, the CSI-RSs for the antenna ports may be multiplexed using FDM, TDM and/or CDM using orthogonal frequency resources, orthogonal time resources and/or orthogonal code resources.", "When the eNB informs a UE belonging to a cell thereof of information about CSI-RSs, the eNB needs to signal information about time and frequency to which a CSI-RS for each antenna port is mapped.", "Specifically, the information about time may include the subframe numbers of subframes in which the CSI-RS is transmitted, a CSI-RS transmission periodicity for transmission of the CSI-RS, a subframe offset for transmission of the CSI-RS, and a number corresponding to an OFDM symbol on which a CSI-RS RE of a specific antenna is transmitted.", "The information about frequency may include spacing of frequencies at which a CSI-RS RE of a specific antenna is transmitted, and an RE offset or a shift value in the frequency domain.", "FIG.", "9 is a diagram illustrating an exemplary scheme in which a CSI-RS is periodically transmitted.", "The CSI-RS may be periodically transmitted with a periodicity corresponding to an integer multiple of one subframe (e.g., 5 subframes, 10 subframes, 20 subframes, 40 subframes, or 80 subframes) FIG.", "9 illustrates a case in which one radio frame consists of 10 subframes (from subframe 0 to subframe 9).", "In the example illustrated in FIG.", "9, the transmission periodicity of the CSI-RS of the eNB is 10 ms (i.e., 10 subframes), and the CSI-RS transmission offset is 3.Different offset values may be assigned to eNBs such that CSI-RSs of several cells are uniformly distributed in the time domain.", "When the CSI-RS is transmitted with a periodicity of 10 ms, the offset may be set to a value between 0 and 9.Similarly, when the CSI-RS is transmitted with a periodicity of, for example, 5 ms, the offset may be set to a value between 0 and 4.When the CSI-RS is transmitted with a periodicity of 20 ms, the offset may be set to a value between 0 and 19.When the CSI-RS is transmitted with a periodicity of 40 ms, the offset may be set to a value between 0 and 39.When the CSI-RS is transmitted with a periodicity of 80 ms, the offset may be set to a value between 0 and 79.The offset value indicates the value of a subframe in which an eNB transmitting the CSI-RS with a predetermined periodicity starts CSI-RS transmission.", "When the eNB informs the UE of the transmission periodicity and the offset value of the CSI-RS, the UE may receive the CSI-RS of the eNB at the corresponding subframe position, using the values.", "The UE may measure a channel through the received CSI-RS, and report information such as CQI, PMI and/or rank indicator (RI) to the eNB as a result of the measurement.", "The CQI, the PMI and the RI may be collectively referred to as CQI (or CSI) throughout the specification unless they are separately described.", "The aforementioned information related to the CSI-RS is cell-specific information and may be applied to the UEs in a cell in common.", "The CSI-RS transmission periodicity and offset may be separately specified for each CSI-RS configuration.", "For example, a separate CSI-RS transmission periodicity and offset may be set for a CSI-RS configuration representing a CSI-RS transmitted with zero transmit power and a CSI-RS configuration representing a CSI-RS transmitted with non-zero transmit power.", "Contrary to the CRS transmitted in all subframes in which a PDSCH can be transmitted, the CSI-RS may be configured to be transmitted only in some subframes.", "For example, CSI subframe sets CCSI,0 and CCSI,1 may be configured by a higher layer.", "CSI reference resource (i.e., a predetermined resource region forming the basis of CSI calculation) may belong to either CCSI,0 or CCSI,1 may not belong to both CCSI,0 and CCSI,1 at the same time.", "Accordingly, when CSI subframe sets CCSI,0 and CCSI,1 are configured by a higher layer, the UE is not allowed to expect that it will receive a trigger (or an indication for CSI calculation) for a CSI reference resource which is present in a subframe which belongs to none of the CSI subframe sets.", "Alternatively, the CSI reference resource may be configured in a valid downlink subframe.", "The valid downlink subframe may be configured as a subframe satisfying various conditions.", "In the case of periodic CSI reporting, one of the conditions may be a subframe belonging to a CSI subframe set that is linked to periodic CSI reporting when a CSI subframe set is configured for the UE.", "The UE may derive a CQI index from the CSI reference resource in consideration of the following assumptions (For details, see 3GPP TS 36.213).", "First three OFDM symbols in a subframe are occupied by control signaling.", "No REs are used by a primary synchronization signal, a secondary synchronization signal, or a physical broadcast channel (PBCH).", "CP length of a non-Multicast Broadcast Single Frequency Network (MBSFN) subframe.", "Redundancy version is 0.If a CSI-RS is used for channel measurement, the ratio of PDSCH energy per resource element (EPRE) to CSI-RS EPRE conforms to a predetermined rule.", "For CSI reporting in transmission mode 9 (i.e., the mode supporting up to 8-layer transmission), if the UE is configured for PMI/RI reporting, it is assumed that DMRS overhead corresponds to the most recently reported rank.", "For example, in the case of two or more antenna ports (i.e., rank less than or equal to 2) as described in FIG.", "7, DMRS overhead on one RB pair is 12 REs, whereas DMRS overhead in the case of three or more antenna ports (i.e., rank greater than or equal to 3) is 24 REs.", "Therefore, a CQI index may be calculated on the assumption of DMRS overhead corresponding to the most recently reported rank value.", "No REs are allocated to a CSI-RS and a zero-power CSI-RS.", "No REs are allocated to a positioning RS (PRS).", "The PDSCH transmission scheme conforms to a transmission mode currently set for the UE (the mode may be a default mode).", "The ratio of PDSCH EPRE to cell-specific RS EPRE conforms to a predetermined rule.", "The eNB may inform UEs of such a CSI-RS configuration through, for example, radio resource control (RRC) signaling.", "That is, information about the CSI-RS configuration may be provided to UEs in a cell using dedicated RRC signaling.", "For example, while a UE establishes a connection with the eNB through initial access or handover, the eNB may inform the UE of the CSI-RS configuration through RRC signaling.", "Alternatively, when the eNB transmits, to a UE, an RRC signaling message demanding channel state feedback based on CSI-RS measurement, the eNB may inform the UE of the CSI-RS configuration through the RRC signaling message.", "Meanwhile, locations of the CSI-RS in the time domain, i.e.", "a cell-specific subframe configuration period and a cell-specific subframe offset, may be summarized as shown in Table 1 below.", "TABLE 1 CSI-RS subframe configuration CSI-RS periodicity CSI-RS subframe offset ICSI-RS TCSI-RS (subframes) ΔCSI-RS (subframes) 0-4 5 ICSI-RS 5-14 10 ICSI-RS − 5 15-34 20 ICSI-RS − 15 35-74 40 ICSI-RS − 35 75-154 80 ICSI-RS − 75 As described above, parameter ICSI-RS may be separately configured for a CSI-RS assumed to have a non-zero transmit power by the UE and a CSI-RS assumed to have zero transmit power by the UE.", "A subframe including a CSI-RS may be represented by Equation 12 below (In Equation 12, nf is a system frame number and ns is a slot number).", "(10nf+└ns/2┘−ΔCSI-RS)mod TCSI-RS=0 Equation 12 CSI-RS-Config information elements (IEs) defined as in Table 2 below may be used to specify a CSI-RS configuration.", "TABLE 2 CSI-RS-Config information elements -- ASN1START CSI-RS-Config-r10 ::= SEQUENCE { csi-RS-r10 CHOICE { release NULL, setup SEQUENCE { antennaPortsCount-r10 ENUMERATED {an1, an2, an4, an8}, resourceConfig-r10 INTEGER (0..31), subframeConfig-r10 INTEGER (0..154), p-C-r10 INTEGER (−8..15) } } OPTIONAL, -- Need ON zeroTxPowerCSI-RS-r10 CHOICE { release NULL, setup SEQUENCE { zeroTxPowerResourceConfigList-r10 BIT STRING (SIZE (16)), zeroTxPowerSubframeConfig-r10 INTEGER (0..154) } } OPTIONAL -- Need ON } -- ASN1STOP In Table 2, parameter ‘antennaPortsCount’ indicates the number of antenna ports (i.e., CSI-RS ports).", "In this parameter, an1 corresponds to one antenna port, and an2 corresponds to two antenna ports.", "In Table 2, parameter ‘p_C’ indicates a ratio between PDSCH energy per resource element (EPRE) and CSI-RS EPRE that is assumed when the UE derives CSI feedback.", "In Table 2, parameter ‘resourceConfig’ has, for example, a value that determines the position of an RE to which a CSI-RS is mapped on an RB pair, as shown in FIG.", "8.In Table 2, parameter ‘subframeConfig’ corresponds to TCSI-RS in Table 1.In Table 2, zeroTxPowerResourceConfigList and zeroTxPowerSubframeConfig correspond to resourceConfig and subframeConfig of a CSI-RS having a zero transmit power, respectively.", "For details of the CSI-RS configuration IE of Table 2, see standard document TS 36.331.Generation of CSI-RS Sequence The RS sequence rl,ns(m) may be defined as Equation 13 below.", "r l , n s  ( m ) = 1 2  ( 1 - 2 · c  ( 2  m ) ) + j  1 2  ( 1 - 2 · c  ( 2  m + 1 ) ) ,   m = 0 , 1 , …  , N RB max , DL - 1 Equation   13 In Equation 13, ns denotes a slot number (or a slot index) in a subframe, and l denotes an OFDM symbol number (or OFDM symbol index) in a slot.", "c(i), which denotes a pseudo-random sequence, is defined as a length-31 gold sequence.", "In generating a pseudo-random sequence, an initialization value is given as cinit.", "cinit may be given as Equation 14 below.", "cinit=210·(7·(ns+1)+l+1)·(2·NIDcell+1)+2·NIDcell+NCP Equation 14 In Equation 13, nS denotes a slot number (or a slot index) in a subframe, and l denotes an OFDM symbol number (or OFDM symbol index) in a slot.", "NIDcell denotes a physical layer cell identifier.", "NCP is set to 1 for normal CP and to 0 for extended CP.", "For details of generation of a CSI-RS sequence, see standard document TS 36.211 v10.4.0.Channel Status Information (CSI) MIMO schemes may be classified into open-loop MIMO and closed-loop MIMO.", "In open-loop MIMO, a MIMO transmitter performs MIMO transmission without receiving CSI feedback from a MIMO receiver.", "In closed-loop MIMO, the MIMO transmitter receives CSI feedback from the MIMO receiver and then performs MIMO transmission.", "In closed-loop MIMO, each of the transmitter and the receiver may perform beamforming based on the CSI to achieve a multiplexing gain of MIMO Tx antennas.", "To allow the receiver (e.g., a UE) to feed back CSI, the transmitter (e.g., an eNB) may allocate a UL control channel or a UL-SCH to the receiver.", "The UE may perform estimation and/or measurement of a downlink channel using a CRS and/or a CSI-RS.", "The CSI fed back to the eNB by the UE may include a rank indicator (RI), a precoding matrix indicator (PMI), and a channel quality indicator (CQI).", "The RI is information about a channel rank.", "The channel rank represents the maximum number of layers (or streams) that can carry different pieces of information in the same time-frequency resources.", "Since the rank is determined mainly according to long-term fading of a channel, the RI may be fed back with a longer periodicity (namely, less frequently) than the PMI and the CQI.", "The PMI is information about a precoding matrix used for transmission from a transmitter and has a value reflecting the spatial characteristics of a channel.", "Precoding refers to mapping transmission layers to Tx antennas.", "A layer-antenna mapping relationship may be determined by the precoding matrix.", "The PMI corresponds to an index of a precoding matrix of an eNB preferred by the UE based on a metric such as signal-to-interference-plus-noise ratio (SINR).", "In order to reduce the feedback overhead of precoding information, the transmitter and the receiver may pre-share a codebook including multiple precoding matrices, and only the index indicating a specific precoding matrix in the codebook may be fed back.", "For example, the PMI may be determined based on the most recently reported RI.", "The CQI is information indicating channel quality or channel strength.", "The CQI may be expressed as a predetermined MCS combination.", "That is, a CQI index that is fed back indicates a corresponding modulation scheme and code rate.", "The CQI may configure a specific resource region (e.g., a region specified by a valid subframe and/or a physical RB) as a CQI reference resource and be calculated on the assumption that PDSCH transmission is present on the CQI reference resource, and the PDSCH can be received without exceeding a predetermined error probability (e.g., 0.1).", "Generally, the CQI has a value reflecting a received SINR which can be obtained when the eNB configures a spatial channel using a PMI.", "For instance, the CQI may be calculated based on the most recently reported RI and/or PMI.", "In a system supporting an extended antenna configuration (e.g., an LTE-A system), additional acquisition of multi user (MU)-MIMO diversity using an MU-MIMO scheme is considered.", "In the MU-MIMO scheme, when an eNB performs downlink transmission using CSI fed back by one UE among multiple users, it is necessary to prevent interference with other UEs because there is an interference channel between UEs multiplexed in the antenna domain.", "Accordingly, CSI of higher accuracy than in a single-user (SU)-MIMO scheme should be fed back in order to correctly perform MU-MIMO operation.", "A new CSI feedback scheme may be adopted by modifying the existing CSI including an RI, a PMI, and a CQI so as to measure and report more accurate CSI.", "For example, precoding information fed back by the receiver may be indicated by a combination of two PMIs (e.g., i1 and i2).", "Thereby, more precise PMI may be fed back, and more precise CQI may be calculated and reported based on such precise PMI.", "Meanwhile, the CSI may be periodically transmitted over a PUCCH and or aperiodically transmitted over a PUSCH.", "For the RI, various reporting modes may be defined depending on which of a first PMI (e.g., W1), a second PMI (e.g., W2), and a CQI is fed back and whether the PMI and/or CQI that is fed back relates to a wideband (WB) or a subband (SB).", "CQI Calculation Hereinafter, CQI calculation will be described in detail on the assumption that the downlink receiver is a UE.", "However, the description of the present invention given below may also be applied to a relay station serving to perform downlink reception.", "A description will be given below of a method for configuring/defining a resource (hereinafter, referred to as a reference resource) forming the basis of calculation of the CQI when the UE reports CSI.", "The CQI is more specifically defined below.", "A CQI that the UE reports corresponds to a specific index value.", "The CQI index has a value indicating a modulation technique, code rate, and the like that correspond to the channel state.", "For example, CQI indexes and analyzed meanings thereof may be given as shown in Table 3 below.", "TABLE 3 CQI index Modulation Code rate × 1024 Efficiency 0 out of range 1 QPSK 78 0.1523 2 QPSK 120 0.2344 3 QPSK 193 0.3770 4 QPSK 308 0.6016 5 QPSK 449 0.8770 6 QPSK 602 1.1758 7 16QAM 378 1.4766 8 16QAM 490 1.9141 9 16QAM 616 2.4063 10 64QAM 466 2.7305 11 64QAM 567 3.3223 1 64QAM 666 3.9023 13 64QAM 772 4.5234 14 64QAM 873 5.1152 15 64QAM 948 5.5547 Based on an observation which is not restricted by time and frequency, the UE may determine the highest CQI index satisfying a predetermined requirement among CQI indexes 1 to 15 of Table 3 with respect to each CQI value reported in uplink subframe n. The predetermined requirement may be that a single PDSCH transmission block which has a combination of a modulation scheme (e.g., MCS) and a transmission block size (TBS) corresponding to the CQI index and occupies a group of downlink physical RBs called a CQI reference resource should be received with a transmission block error probability not exceeding 0.1 (i.e., 10%).", "If even CQI index 1 does not satisfy the aforementioned requirement, the UE may determine CQI index 0.In transmission mode 9 (corresponding to transmission of up to 8 layers) and the feedback reporting mode, the UE may perform channel measurement for calculation of the CQI value reported in uplink subframe n based only on the CSI-RS.", "In the other transmission modes and corresponding reporting modes, the UE may perform channel measurement for CQI calculation based on the CRS.", "If all requirements given below are satisfied, a combination of a modulation scheme and a TBS may correspond to one CQI index.", "That is, the combination should be allowed to be signaled on a PDSCH in a CQI reference resource according to an associated TRS table, the modulation scheme should be indicated by a corresponding CQI index, and when the combination of a TBS and a modulation scheme is applied to the reference resource, a valid channel code rate as close to the code rate indicated by the CQI index as possible should be given.", "If two or more combinations of a TBS and a modulation scheme are almost equal to the code rate indicated by the corresponding CQI index, a combination having the smallest TBS may be determined.", "A CQI reference resource is defined as the following.", "In the frequency domain, the CQI reference resource defined as a group of downlink physical RBs corresponds to a band associated with the derived CQI value.", "In the time domain, the CQI reference resource is defined as a single downlink subframe n-nCQI_ref.", "In the case of periodic CQI reporting, nCQI_ref is determined to have a value that is smallest among the values greater than or equal to 4 and corresponds to a downlink subframe in which downlink subframe n-nCQI_ref is valid.", "In the case of aperiodic CQI reporting, a downlink subframe identical to a valid downlink subframe corresponding to a CQI request in an uplink DCI format (namely, the PDCCH DCI format for providing the UE with uplink scheduling control information) (or having a received CQI request) is determined as a CQI reference resource for nCQI_ref.", "In aperiodic CQI reporting, nCQI_ref may be 4, and downlink subframe n-nCQI_ref may correspond to a valid downlink subframe.", "Herein, downlink subframe n-nCQI_ref may be received after a subframe corresponding to a CQI request in a random access response grant (or having a received CQI request).", "The valid downlink subframe refers to a downlink subframe that is configured for the UE, is not set as a MBSFN subframe except in transmission mode 9, and neither includes a DwPTS field if the length of DwPTS is less than or equal to 7680*Ts (Ts=1/(15000×2048) seconds), nor belongs to a measurement gap configured for the UE.", "If there is no valid downlink subframe for the CQI reference resource, CQI reporting is not performed in uplink subframe n. In the layer region, the CQI reference resource is defined as a RI and PMI which the CQI presumes.", "The following assumptions may be made for the UE to derive a CQI index on a CQI reference resource: (1) the first three OFDM symbols in a downlink subframe are used for control signaling; (2) there is no RE that is used by a primary synchronization signal, a secondary synchronization signal, or a PBCH; (3) CP length of a non-MBSFN subframe is given; (4) Redundancy version is 0; (5) If a CSI-RS is used for channel measurement, the ratio of PDSCH energy per resource element (EPRE) to CSI-RS EPRE has a predetermined value signaled by a higher layer; (6) a PDSCH transmission scheme (single antenna port transmission, transmission diversity, spatial multiplexing, MU-MIMO, etc.)", "defined for each transmission mode (e.g., a default mode) is currently set for the UE; (7) if the CRS is used for channel measurement, the ratio of PDSCH EPRE to CRS EPRE may be determined according to a predetermined requirement.", "For details related to definition of the CQI, see 3GPP TS 36.213.In summary, the downlink receiver (e.g., a UE) may configure a specific single subframe of the past as a CQI reference resource with respect to the current time at which it is performing CQI calculation, and when a PDSCH is transmitted from the eNB on the CQI reference resource, may calculate a CQI value such that a condition that the error probability should not exceed 10% is satisfied.", "Coordinated Multi-Point (CoMP) To satisfy enhanced system performance requirements for the 3GPP LTE-A system, CoMP transmission and reception technology (also called co-MIMO, collaborative MIMO or network MIMO) has been proposed.", "CoMP technology may increase performance of UEs located at a cell edge and average sector throughput.", "In a multi-cell environment with a frequency reuse factor set to 1, the performance of a UE located at a cell edge and average sector throughput may be lowered due to inter-cell interference (ICI).", "To attenuate ICI, the legacy LTE system has adopted a simple passive technique such as fractional frequency reuse (FFR) based on UE-specific power control such that a UE located at a cell edge may have appropriate throughput performance in an environment constrained by interference.", "However, attenuating the ICI or reusing ICI as a desired signal for the UE may be more desirable than using fewer frequency resources per cell.", "To this end, a CoMP transmission technique may be employed.", "CoMP schemes applicable to downlink may be broadly classified into joint processing (JP) and coordinated scheduling/beamforming (CS/CB).", "According to the JP scheme, data can be used by each transmission point (eNB) of a CoMP cooperation unit.", "The CoMP cooperation unit refers to a set of eNBs used for a CoMP transmission scheme.", "The JP scheme may be further divided into joint transmission and dynamic cell selection.", "Joint transmission refers to a technique of simultaneously transmitting PDSCHs from a plurality of points (a part or the entirety of a CoMP cooperation unit).", "That is, a plurality of transmission points may simultaneously transmit data to a single UE.", "With the joint transmission scheme, the quality of a received signal may be coherently or non-coherently improved, and interference with other UEs may be actively eliminated.", "Dynamic cell selection is a technique of transmitting a PDSCH from one point (of a CoMP cooperation unit) at a time.", "That is, one point transmits data to a single UE at a given time point, while the other points in the CoMP cooperation unit do not transmit data to the UE at the time point.", "A point to transmit data to a UE may be dynamically selected.", "Meanwhile, in the CS/CB scheme, CoMP cooperation units may cooperatively perform beamforming for data transmission to a single UE.", "While data is transmitted to the UE only from a serving cell, user scheduling/beamforming may be determined through coordination among cells of the CoMP cooperation units.", "In the case of uplink, CoMP reception refers to reception of a signal transmitted through cooperation among a plurality of geographically separated points.", "CoMP schemes applicable to uplink may be classified into joint reception (JR) and coordinated scheduling/beamforming (CS/CB).", "The JR scheme indicates that a plurality of reception points receives a signal transmitted through a PUSCH.", "The CS/CB scheme indicates that only one point receives a PUSCH, and user scheduling/beamforming is determined by coordination among the cells of the CoMP unit.", "With a CoMP system as above, multi-cell base stations may jointly support data for a UE.", "In addition, the base stations may simultaneously support one or more UEs using the same radio frequency resources, thereby increasing system performance.", "Moreover, a base station may perform space division multiple access (SDMA) based on CSI between the UE and the base station.", "In the CoMP system, a serving eNB and one or more cooperative eNBs are connected to a scheduler over a backbone network.", "The scheduler may receive channel information about the channel states between each UE and cooperative eNBs measured and fed back by the cooperative eNBs over the backbone network, and operate based on the channel information.", "For example, the scheduler may schedule information for a cooperative MIMO operation for the serving eNB and the one or more cooperative eNBs.", "That is, the scheduler may directly give each eNB a command to perform the cooperative MIMO operation.", "As noted from the above description, it can be said that the CoMP system operates as a virtual MIMO system by grouping a plurality of cells into one group.", "Basically, the CoMP system may adopt a MIMO communication scheme employing multiple antennas.", "Carrier Aggregation Before description is given of carrier aggregation, the concept of cell introduced to manage radio resources in LTE-A will be described first.", "A cell may be understood as a combination of downlink resources and uplink resources.", "Here, the uplink resource is not an essential element of the cell.", "Accordingly, a cell may include only downlink resources or include downlink resources and uplink resources.", "The downlink resource may be referred to as a downlink component carrier (DL CC), and the uplink resource may be referred to as an uplink component carrier (UL CC).", "The DL CC and the UL CC may be represented by carrier frequencies, and a carrier frequency represents a center frequency within the corresponding cell.", "Cells may be divided into a primary cell (PCell), which operates at a primary frequency, and a secondary cell (SCell), which operates at a secondary frequency.", "The PCell and the SCell may be collectively referred to as a serving cell.", "A cell designated when the UE performs an initial connection establishment procedure or during a connection re-establishment procedure or a handover procedure, may serve as the PCell.", "In other words, the PCell may be understood as a cell that serves as a control-related center in a carrier aggregation environment, which will be described in detail later.", "A UE may be assigned a PUCCH in the PCell thereof and may then transmit the assigned PUCCH.", "The SCell may be configured after establishment of radio resource control (RRC) connection, and SCell may be used for providing additional radio resources.", "In the carrier aggregation environment, all serving cells except the PCell may be viewed as SCells.", "In the case in which a UE is in an RRC_CONNECTED state but carrier aggregation is not established or in a case in which the UE does not support carrier aggregation, only a single serving cell consisting of PCells exists.", "On the other hand, in the case in which a UE is in the RRC_CONNECTED state and carrier aggregation is established therefor, one or more serving cells exist, and PCells and all SCells are included in all serving cells.", "For a UE supporting carrier aggregation, after an initial security activation procedure is initiated, the network may configure one or more SCells in addition to a PCell configured at the beginning of the connection establishment procedure.", "FIG.", "10 illustrates carrier aggregation Carrier aggregation is a technology that has been introduced to allow for use of a broader band in order to meet the requirements of a high-speed transmission rate.", "Carrier aggregation may be defined as an aggregation of two or more component carriers (CCs) having different carrier frequencies or an aggregation of two or more cells.", "Referring to FIG.", "10, FIG.", "10(a) illustrates a subframe in a case when one CC is used in the legacy LTE system, and FIG.", "10(b) illustrates a subframe in a case where carrier aggregation is used.", "For example, in FIG.", "10(b), 3 CCs of 20 MHz are used, thereby supporting a bandwidth of 60 MHz.", "Herein, CCs may be continuous or non-continuous in the frequency domain.", "The UE may simultaneously receive and monitor downlink data from a plurality of DL CCs.", "A linkage between a DL CC and a UL CC may be indicated by the system information.", "The DL CC/UL CC link may be fixed in the system or may be semi-statically configured.", "Additionally, even if the entire system band consists of N CCs, the frequency band in which a specific UE can perform monitoring/reception may be limited to M(<N) CCs.", "Various parameters for carrier aggregation may be set up in a cell-specific, UE group-specific, or UE-specific manner.", "FIG.", "11 illustrates cross-carrier scheduling.", "Cross-carrier scheduling refers to, for example, including all downlink scheduling allocation information about a DL CC in the control region of another DL CC for one of multiple serving cells or including all uplink scheduling grant information about multiple UL CCs linked to a DL CC for one of multiple serving cells in the control region of the DL CC.", "Regarding cross-carrier scheduling, a carrier indicator field (CIF) will be described first.", "The CIF may be included in the DCI format transmitted over the PDCCH (and be defined to have, for example, the size of 3 bits), or may not be included in the DCI format (in this case, the CIF may be defined to have, for example, the size of 0 bit).", "If the CIF is included in the DCI format, this indicates that cross-carrier scheduling is applied.", "In the case in which cross-carrier scheduling is not applied, the downlink scheduling allocation information is valid within the DL CC through which downlink scheduling allocation information is currently being transmitted.", "Additionally, the uplink scheduling grant is valid for a UL CC linked to the DL CC through which the downlink scheduling allocation information is transmitted.", "In the case in which cross-carrier scheduling is applied, the CIF indicates a CC related to the downlink scheduling allocation information which is transmitted over the PDCCH in a DL CC.", "For example, referring to FIG.", "11, downlink allocation information about DL CC B and DL CC C, i.e., information about PDSCH resources, is transmitted over the PDCCH within the control region of DL CC A.", "The UE may monitor DL CC A so as to recognize the resource region of the PDSCH and the corresponding CC through the CIF.", "Whether or not the CIF is included in the PDCCH may be semi-statically set, and the CIF may be UE-specifically enabled by higher-layer signaling.", "When the CIF is disabled, the PDCCH in a specific DL CC allocates a PDSCH resource in the same DL CC and may also allocate a PUSCH resource in a UL CC linked to the specific DL CC.", "In this case, the same coding scheme, CCE-based resource mapping, DCI format, and so on, as in the legacy PDCCH structure, may be applied.", "When the CIF is enabled, the PDCCH in a specific DL CC may allocate a PDSCH/PUSCH resource within a single DL/UL CC indicated by the CIF, among the multiple aggregated CCs.", "In this case, a CIF may be additionally defined in the legacy PDCCH DCI format.", "The CIF may be defined as a field having a fixed length of 3 bits, or the CIF position may be fixed regardless of the size of the DCI format.", "The coding scheme, CCE-based resource mapping, DCI format, and so on of the legacy PDCCH structure may be applied to this case.", "When the CIF exists, an eNB may allocate a DL CC set in which the PDCCH is to be monitored.", "Accordingly, the burden of blind decoding to the UE may be lessened.", "The PDCCH monitoring CC set corresponds to a portion of all aggregated DL CCs, and the UE may perform PDCCH detection/decoding only in the corresponding CC set.", "In other words, in order to perform PDSCH/PUSCH scheduling for a UE, the eNB may transmit the PDCCH only in the PDCCH monitoring CC set.", "The PDCCH monitoring CC set may be UE-specifically or UE group-specifically or cell-specifically configured.", "For example, when 3 DL CCs are aggregated as illustrated in FIG.", "6, DL CC A may be configured as a PDCCH monitoring DL CC.", "If the CIF is disabled, the PDCCH in each DL CC may schedule only the PDSCH within the DL CC A.", "On the other hand, if the CIF is enabled, the PDCCH in DL CC A may schedule not only the PDCCH of the DL CC A but also the PDSCH of the other DL CCs.", "In the case where the DL CC A is configured as the PDCCH monitoring CC, the PDCCH may not be transmitted in DL CC B and DL CC C. PDCCH Processing Control channel elements (CCEs), which are contiguous logical allocation units, are used in mapping PDCCHs to REs.", "A CCE includes a plurality of resource element groups (e.g., 9 REGs).", "Each REG includes four REs which may neighbor each other if the RS is excluded.", "The number of CCEs necessary for a specific PDCCH depends on a DCI payload corresponding to the size of control information, a cell bandwidth, a channel coding rate, etc.", "Specifically, the number of CCEs for a specific PDCCH may be defined according to PDCCH formats as shown in Table 4.TABLE 4 PDCCH Number of Number of Number of format CCEs REGs PDCCH bits 0 1 9 72 1 2 18 144 2 4 36 288 3 8 72 576 One of the four formats may be used for a PDCCH, but this is not known to the UE.", "Accordingly, the UE needs to perform decoding without knowing the PDCCH format.", "This is called blind decoding.", "Since decoding as many CCEs used for downlink as possible for each PDCCH format causes significant load to the UE, a search space is defined in consideration of restriction on the scheduler and the number of attempts to perform decoding.", "That is, the search space is an aggregation of candidate PDCCHs including CCEs which the UE needs to attempt to decode at an aggregation level.", "Each aggregation level and the corresponding number of candidate PDCCHs may be defined as shown in Table 5 below.", "TABLE 5 Search space Aggregation Size (in Number of PDCCH level CCE units) candidates UE-specific 1 6 6 2 12 6 4 8 2 8 16 2 Common 4 16 4 8 16 2 As shown in Table 5, there are 4 aggregation levels, and the UE has a plurality of search spaces according to the aggregation levels.", "The search spaces may be divided into a UE-specific search space and a common search space, as shown in Table 5.The UE-specific search space is for specific UEs.", "Each UE may check an RNTI and CRC with which the PDCCH is masked, by monitoring the UE-specific search space thereof (attempting to decode an aggregation of PDCCH candidates according to a possible DCI format) and acquire control information if the RNTI and CRC are valid.", "The common search space is intended for use in the case in which a plurality of UEs or all UEs need to receive PDCCHs, as in the cases of system information dynamic scheduling and paging messages.", "The common search space may be used for a specific UE in terms of resource management.", "Furthermore, the common search space may overlap the UE-specific search space.", "In this manner, the UE attempts to perform decoding in a search space.", "The number of decoding attempts is determined by a DCI format and a transmission mode determined through radio resource control (RRC) signaling.", "If carrier aggregation is not applied, the UE needs to attempt to perform decoding up to 12 times for each of six PDCCH candidates in the common search space, in consideration of two DCI sizes (DCI formats 0/1A/3/3A and DCI format 1C).", "In the UE-specific search space, the UE needs to attempt to perform decoding for each of 16 (6+6+2+2=16) PDCCH candidates up to 32 times, in consideration of two DCI sizes.", "Accordingly, when carrier aggregation is not applied, the UE needs to attempt to perform decoding up to 44 times.", "Enhanced Control Channel Hereinafter, an enhanced PDCCH (EPDCCH) will be described as an example of enhanced control channels.", "Control information included in the aforementioned DCI formats has been described in terms of a case in which the control information is transmitted through a PDCCH defined in LTE/LTE-A.", "However, the control information can be applied to another DL control channel, for example, an E-PDCCH in place of the PDCCH.", "The EPDCCH may correspond to a new form of a control channel for carrying DCI such as scheduling allocation for the UE and may be introduced in order to effectively support a scheme such as inter-cell interference coordination (ICIC), CoMP, MU-MIMO, etc.", "The EPDCCH is differentiated from the existing PDCCH in that the EPDCCH is allocated to a time-frequency resource region (e.g., the data region of FIG.", "3) except for a region (e.g., the control region of FIG.", "3) defined for PDCCH transmission in a legacy LTE/LTE-A system (hereinafter, the existing PDCCH will be referred to as a legacy-PDCCH in order to differentiate the PDCCH from the EPDCCH).", "For example, mapping of resource elements of the EPDCCH may be expressed as mapping the resource elements to OFDM symbols except for first N (e.g., N≤4) OFDM symbols of a DL subframe in the time domain and mapping the resource elements to a set of semi-statically allocated resource blocks (RBs) in the frequency domain.", "For a reason similar to that for introduction of the EPDCCH, an E-PHICH may be defined as a new control channel for carrying HARQ ACK/NACK information about UL transmission and an E-PCFICH may be defined as a new control channel for carrying information about a resource region used for DL control channel transmission.", "The EPDCCH, the E-PHICH, and/or the E-PCFICH may be collectively referred to as an enhanced-control channel.", "An enhanced REG may be used to define mapping of enhanced-control channels to resource elements.", "For example, for one physical resource block (PRB) pair, 16 EREGs (i.e., EREG 0 to EREG 15) may be present.", "On one PRB, REs except for REs to which demodulation reference signals (DMRSs) are mapped are denoted by numbers 0 to 15.The numbers are assigned in an order in which frequency increases and then in an order in which time increases.", "For example, REs denoted by i constitute EREG i. Enhanced-control channels may be transmitted using aggregation of one or more enhanced CCEs (ECCEs).", "Each ECCE may include one or more EREGs.", "The number of EREGs per ECCE may be, for example, 4 or 8 (4 in the case of a general subframe of a normal CP).", "Available ECCEs for the enhanced-control channel may be denoted by numbers 0 to NECCE−1.NECCE may be, for example, 1, 2, 4, 8, 16, or 32.The number of REs of a PRB pair configured for transmission of the enhanced-control channel may be defined to satisfy the following conditions i), ii), and iii): i) the REs are contained in one of 16 EREGs of the PRB pair; ii) the REs are not used for a cell-specific reference signal (CRS) or a channel state information-reference signal (CSI-RS); and iii) the enhanced-control channel belongs to an OFDM symbol with an index that is greater than or equal to the index of an OFDM symbol on which a control channel is started.", "In addition, enhanced-control channels may be mapped to REs in a localized manner or a distributed manner.", "The enhanced-control channel may be mapped to REs that satisfy the following conditions a) to d): a) the REs are contained in an EREG allocated for transmission, b) the REs are not a part of a PRB pair used in transmitting a physical broadcast channel (PBCH) or a synchronization signal; c) the REs are not used for a CRS or a CSI-RS for a specific UE; and d) the enhanced-control channel belongs to an OFDM symbol with an index that is greater than or equal to the index of an OFDM on which the enhanced-control channel starts.", "Allocation of the enhanced-control channel may be performed as the following.", "One or more enhanced-control channel-PRB-sets may be configured for the UE through higher layer signaling from an eNB.", "For example, in the case of the EPDCCH, the enhanced-control channel-PRB-set may be used for monitoring of the EPDCCH.", "In addition, cross interleaving may or may not be applied to mapping of the enhanced-control channel to REs.", "When cross interleaving is not applied, one enhanced-control channel may be mapped to a specific set of RBs, and the number of RBs included in the RB set may correspond to an aggregation level of 1, 2, 4, or 8.In addition, another enhanced-control channel may not be transmitted in this RB set.", "When cross interleaving is applied, a plurality of enhanced-control channels may be multiplexed and interleaved together and mapped to an RB allocated for enhanced-control channel transmission.", "That is, multiple enhanced-control channels may also be expressed as being mapped together to a specific resource block set.", "DCI Format 1A DCI format 1A refers to DCI formats which are used for compact scheduling of one PDSCH codeword in a cell.", "That is, DCI format 1A may include control information that is used for rank-1 transmission such as single antenna transmission, single stream transmission, or transmission diversity transmission.", "Tables 3 and 4 show examples of DCI format 1A that is defined in the legacy 3GPP LTE/LTE-A standard.", "TABLE 6 Carrier Indicator 0 or 3 bits Flag for format 0/format 1A differentiation 1 bit Localized/Distributed VRB assignment Flag 1 bit Resource Block Assignment N bits Modulation and coding scheme 5 bits HARQ process number 3 bits (FDD), 4 bits (TDD) New Data Indicator 1 bit Redundancy Version 2 bits TPC (Transmit Power Control) command for 2 bits PUCCH Downlink Assignment Index 0 bit (FDD), 2 bits (TDD) SRS (Sounding Reference Signal) request 0 or 1 bit DCI format 1A containing control information as shown in Table 6 may be provided to the UE over a PDCCH or an EPDCCH by the eNB.", "DCI format 1A contains information for scheduling the most basic DL transmission (transmission of one PDSCH codeword with rank 1).", "Accordingly, in the case in which a complex PDSCH transmission scheme such as transmission with a rank higher than or equal to 2 and/or transmission of a plurality of codewords is not correctly implemented, DCI format 1A may be used to support the most basic PDSCH transmission scheme (i.e., fallback).", "Quasi Co-Location (QCL) Hereinafter, a QC or QCL (Quasi Co-Located) relationship will be described in terms of signal or channel.", "When large-scale properties of a signal received through one antenna port can be inferred from another signal received through another antenna port, the two antenna ports may be said to be QCL.", "Herein, the large-scale properties may include at least one of a delay spread, a Doppler shift, a frequency shift, an average received power, and received timing.", "Alternatively, two antenna ports may be said to be QCL when large-scale properties of a channel over which a symbol on one antenna port is transmitted can be inferred from properties of a channel over which another symbol on the other antenna port is transmitted.", "Herein, the large-scale properties may include at least one of a delay spread, a Doppler spread, a Doppler shift, an average gain, and an average delay.", "In using the term QC or QCL in this disclosure, the definition thereof is not distinguished in terms of the signals or channels described above.", "The UE may assume that any two antenna ports having the QCL assumption established therebetween are co-located even if the antenna ports are not actually co-located.", "For example, the UE may assume that two antenna ports having the QCL assumption established therebetween are at the same transmission point (TP).", "For example, a specific CSI-RS antenna port, a specific downlink DMRS antenna port, and a specific CRS antenna port may be configured to be QCL.", "This configuration may correspond to a case in which the specific CSI-RS antenna port, the specific downlink DMRS antenna port, and the specific CRS antenna port are from one serving cell.", "Alternatively, a CSI-RS antenna port and a downlink DMRS antenna port may be configured to be QCL.", "For example, in a CoMP environment in which a plurality of TPs participates, a TP from which a CSI-RS antenna port is actually transmitted may not be explicitly known to the UE.", "In this case, the UE may be informed that a specific CSI-RS antenna port and a specific DMRS antenna port are QCL.", "This may correspond to a case in which the specific CSI-RS antenna port and the specific DMRS antenna port are from a certain TP.", "In this case, the UE may increase the performance of channel estimation through a DMRS, based on the information about large-scale properties of a channel acquired using a CSI-RS or a CRS.", "For example, the UE may perform an operation of, for example, attenuating interference of a channel estimated through the DMRS, using the delay spread of a channel estimated through the CSI-RS.", "For example, regarding delay spread and Doppler spread, the UE may apply estimation results of the power-delay-profile, the delay spread and Doppler spectrum and the Doppler spread for one antenna port to a Wiener filter which is used in performing channel estimation for another antenna port.", "In addition, regarding frequency shift and received timing, after the UE performs time and frequency synchronization for an antenna port, it may apply the same synchronization to demodulation on another antenna port.", "Further, regarding average received power, the UE may average measurements of reference signal received power (RSRP) over two or more antenna ports.", "For example, the UE may receive information about a DL scheduling grant through a specific DMRS-based DL-related DCI format (e.g., DCI format 2C) over a PDCCH (or an EPDCCH).", "In this case, the UE performs channel estimation of a scheduled PDSCH through a configured DMRS sequence and then performs data demodulation.", "For example, if the UE can make a QCL assumption that a DMRS port configuration received from the DL scheduling grant and a port for a specific RS (e.g., a specific CSI-RS, a specific CRS, a DL serving cell CRS of the UE, etc.)", "are QCL, then the UE may apply the estimates of the large-scale properties such as the delay spread estimated through the port for the specific RS to implementation of channel estimation through the DMRS port, thereby improving performance of DMRS-based reception.", "This is because the CSI-RS or CRS is a cell-specific signal transmitted over the full band in the frequency domain, and thus allows for more accurate recognition of large-scale properties of a channel than the DMRS.", "Particularly, the CRS is a reference signal that is broadcast with a relatively high density over the full band in every subframe as described above, and thus, generally, estimates of the large-scale properties of a channel may be more stably and accurately acquired from the CRS.", "On the other hand, the DMRS is UE-specifically transmitted only on specific scheduled RBs, and accordingly accuracy of estimates of the large-scale properties of a channel is lower than in the case of the CRS or the CSI-RS.", "In addition, even if a plurality of physical resource block groups (PBRGs) are scheduled for a UE, an effective channel received by the UE may change on a PRBG-by-PRBG basis since a precoding matrix that the eNB uses for transmission may change on the PRBG-by-PRBG basis.", "Therefore, even if large-scale properties of a radio channel are estimated based on the DMRS over a wide band, the accuracy of estimation may be low.", "For antenna ports (APs) which are not QCL (non-quasi-co-located (NQC)), the UE cannot assume that the APs have the same large-scale properties.", "In this case, the UE needs to perform independent processing for each NQC AP regarding timing acquisition and tracking, frequency offset estimation and compensation, delay estimation, and Doppler estimation.", "Information indicating whether or not APs are QCL may be provided to the UE through downlink control information (e.g., a PQI field of DCI format 2D (a PDSCH RE mapping and QCL indicator field)).", "Specifically, parameter sets of a QCL configuration may be preconfigured by a higher layer, and a specific one of the QCL parameter sets may be indicated through the PQI field of DCI format.", "Method for Signaling QC-Related Information According to one embodiment of the present invention, an eNB may signal QC assumption information between RSs such as a CRS, a CSI-RS, and a DMRS, thereby improving performance of CSI feedback and reception processing in the UE.", "Higher Layer Signaling of QC-Related Information Hereinafter, descriptions will be given of embodiments of the present invention in which QC-related information is configured through higher layer (e.g., RRC) signaling.", "For example, when the UE receives signaling of one or more CSI-RS configuration(s) through a higher layer, whether or not QC assumption with specific RS(s) is possible may be indicated for each CSI-RS configuration (herein, the specific RS may be a CRS of a specific cell (e.g., a DL serving cell or a neighboring cell) of the UE, another CSI-RS, or a DMRS).", "The UE configured as above may apply such QC assumption or NQC assumption to calculation/determination of information (e.g., RI, PMI, CQI, etc.)", "to be reported in feeding back CSI based on each CSI-RS configuration.", "As an example of higher layer signaling of QC-related information, an operation depending on whether QC/NQC assumption between a CSI-RS port and a CRS port is applied will be described.", "For example, a UE may receive signaling of a plurality of CSI-RS configurations.", "In the description below, CSI-RS configurations may be understood as CSI-RS resources.", "For example, the UE may receive signaling of CSI-RS configuration 1 (hereinafter, referred to as “CSI-RS1”) and CSI-RS configuration 2 (hereinafter, referred to as “CSI-RS2”) through a higher layer.", "In addition, it may be signaled by the higher layer that it can be assumed that CSI-RS1 and the DL serving cell CRS are QC and that CSI-RS2 and the DL serving cell CRS are NQC.", "In this case, the UE may perform CSI calculation using CSI-RS1 for which QC assumption with the DL serving cell CRS is possible based on the following assumption.", "In calculating CSI, the UE may calculate/determine RI, PMI, CQI, and the like that do not exceed a predetermined error rate in performing data demodulation on the assumption that a DMRS-based PDSCH is received.", "In this case, the UE may calculate an RI, a PMI, a CQI, and the like with which the UE can achieve an FER less than or equal to 10% of the FER obtained in the case of data demodulation on the assumption that a corresponding PDSCH DMRS port(s) has a QC relationship with the DL serving cell CRS.", "In addition, in calculating CSI using CSI-RS1, the QC assumption may be reflected in a Pc value (see parameter p_C of Table 2) contained in the CSI-RS configuration, in a manner that predetermined scaling considering the DL serving cell CRS is applied.", "Meanwhile, since CSI-RS2 is configured to have an NQC relationship with the DL serving cell CRS, the UE does not adopt the QC assumption between the PDSCH DMRS port(s) and the DL serving cell CRS when calculating/determining RI, PMI and CQI, assuming that a DMRS-based PDSCH is received from the TP having transmitted CSI-RS2.In other words, the UE may calculate/determine an RI, a PMI and a CQI with which the UE can achieve an FER less than or equal to 10% of the FER obtained in the case of data demodulation through the DMRS-based PDSCH without the QC assumption.", "For example, the UE may calculate/determine an MCS level, a CQI, an RI, and the like lower (namely, expected to provide more robust transmission) than when the QC assumption is applicable, and report the same to the eNB.", "As another example of higher layer signaling of QC-related information, information indicating whether or not QC/NQC assumption between CSI-RS port(s) for a specific CSI-RS configuration and CSI-RS port(s) for another CSI-RS configuration is applied may be included in higher layer signaling.", "For example, it is proposed that predetermined location information be included in each CSI-RS configuration to be interpreted as indicating that QC assumption can be made between CSI-RSs having the same location value.", "The location information may have a size of N bits.", "For example, it may be assumed that an eNB having a 2-dimensional uniform rectangular antenna array (URA) including L×M antennas performs 3-dimensional beamforming.", "In this case, the eNB may signal that multiple CSI-RS configurations established for one UE by a 2-dimensional URA have a QC relationship therebetween.", "Accordingly, the UE may apply part or all of large-scale properties (e.g., delay spread, Doppler spread, frequency shift, received timing, etc.)", "measured for a specific CSI-RS port for one CSI-RS configuration to a CSI-RS port for another CSI-RS configuration.", "Thereby, channel estimation complexity of the UE may be significantly reduced.", "However, if average received powers for different CSI-RS configurations are assumed to have a QC relationship among other large-scale channel properties, a 3-dimensional beamforming gain may not be sufficiently achieved.", "Accordingly, in determining average received power, CSI-RS ports belonging to different CSI-RS configurations may be assumed to have an NQC relationship.", "In another example, each CSI-RS configuration may include a flag bit.", "Every time the flag bit is toggled, it may be indicated whether or not a corresponding CSI-RS configuration belongs to the same group of CSI-RS configurations subject to the QC assumption.", "For example, if the value of the flag bit is toggled, (namely, if the flag bit of a corresponding CSI-RS configuration changes from 0 to 1 or from 1 to 0 with respect to the flag bit of the previous CSI-RS configuration), it may be indicated that the CSI-RS configuration belongs to a group different from the group to which the previous CSI-RS configuration belongs.", "If the flag bit is not toggled, this may indicate that the CSI-RS configuration belongs to the group to which the previous CSI-RS configuration belongs.", "For example, suppose that 5 CSI-RS configurations (CSI-RS1, CSI-RS2, .", ".", ".", ", CSI-RS5) are signaled to the UE and that the flag bits for CSI-RS1 and CSI-RS2 are set to ‘0’, flag bits for CSI-RS3 and CSI-RS4 are set to ‘1’, and the flag bit for CSI-RS5 is toggled to ‘0’.", "In this case, it may be indicated that QC assumption is possible between CSI-RS1 and CSI-RS2 and between CSI-RS3 and CSI-RS4 and that CSI-RS5 does not have a QC relationship with the other CSI-RSs (namely, CSI-RS5 has an NQC relationship with the other CSI-RSs).", "Additionally, it can be seen that QC assumption cannot be made between CSI-RS1 or CSI-RS2 and CSI-RS3 or CSI-RS4.In another example, when X indicates the value of a CSI-RS sequence scrambling seed included in each CSI-RS configuration, whether or not QC assumption is applied may be implicitly indicated depending on whether or not the X values are equal.", "For example, if CSI-RS configurations have the same X value, it may be indicated that QC assumption is applied to the CSI-RS port(s) for the CSI-RS configurations.", "If CSI-RS configurations have different X values, it may be indicated that NQC assumption is applied to the CSI-RS port(s) for the CSI-RS configurations.", "Herein, the X value is included in the CSI-RS configurations which are UE-specifically established, and accordingly it may be set independently of a physical cell identifier (PCI), which is cell-specifically given, and be referred to as a virtual cell identifier (VCI).", "X may be set to an integer between 0 and 503 as in the case of the PCI, but need not have the same value as the PCI.", "If the value of X included in a specific CSI-RS configuration is equal to the PCI value of specific CRS port(s), it may be implicitly indicated that QC assumption may be possible between the CSI-RS port(s) of the CSI-RS configuration and the specific CRS port(s).", "If the value of X included in a specific CSI-RS configuration is not equal to the PCI value of specific CRS port(s), it may be implicitly indicated that NQC assumption may be possible between the CSI-RS port(s) of the CSI-RS configuration and the specific CRS port(s).", "Additionally, X indicating a CSI-RS scrambling sequence seed value may be individually allocated to each CSI-RS port in one CSI-RS configuration.", "In this case, whether or not QC/NQC assumption between a CSI-RS port and another RS port (e.g., a CSI-RS port of another CSI-RS configuration, another CSI-RS port in the same CSI-RS configuration, and/or a CRS port) is applied may be implicitly indicated depending on whether the X values of the respective CSI-RS ports (or the X value for a specific CSI-RS port and the PCI value for a specific CRS) are equal to each other.", "In another example of higher layer signaling of QC-related information, a specific CSI-RS configuration may contain information indicating whether or not QC/NQC assumption between a corresponding port and another DMRS port is applied.", "For example, whether or not QC/NQC assumption specific DMRS port(s) is applied may be indicated for each CSI-RS configuration through RRC.", "If the UE receives a configuration of CSI-RS1 to which i QC assumption with all DMRS port(s) is applicable, the UE may apply estimates of large-scale properties obtained using CSI-RS1 to DMRS-based PDSCH reception.", "Upon receiving the configuration of CSI-RS1, the UE may interpret this configuration as meaning that the eNB will semi-statically (namely, as long as the CSI-RS is not reconfigured) transmit a PDSCH to the UE from a TP having transmitted CSI-RS1.In particular, in CoMP scenario 4 (i.e., in a situation in which CRSs are simultaneously transmitted from multiple TPs having the same cell ID), it is difficult to apply a TP-specific QC assumption through such CRSs, and accordingly information about DMRS port(s) for which QC assumption with CSI-RS port(s) is established may be signaled to the UE such that the information is utilized in improving performance of DMRS-based reception processing.", "In another example, it is assumed that the UE receives configurations of CSI-RS1 and CSI-RS2 with QC assumption applied between CSI-RS1 and a DL serving cell CRS and NQC assumption applied between CSI-RS2 and the DL serving cell CRS.", "In this case, the UE may interpret this reception/operate as having received an implicit semi-static indication that QC assumption with both CSI-RS1 and the DL serving cell CRS is applied to DMRS port(s).", "For example, as the UE receives a configuration indicating that QC assumption is possible between CSI-RS1 and the DL serving cell CRS, the UE may report, when feeding back CSI based on CSI-RS 1, CSI feedback information such as an MCS level and CQI which are higher than when NQC assumption is established.", "Accordingly, if the eNB signals that QC assumption is applied to CSI-RS1 and the DL serving cell CRS (and does not signal otherwise), the UE may interpret this signaling as an agreement that the eNB will cause a TP having transmitted CSI-RS1 to transmit a DMRS-based PDSCH when the eNB schedules DL transmission for the UE.", "Thus, the UE may report CSI feedback information based on CSI-RS1 for which QC is assumed, and receive a PDSCH by applying the QC assumption.", "Thereby, performance of reception processing may be improved.", "Specifically, if any of multiple CSI-RS configurations in a CoMP measurement set is allowed to have a QC assumption with the DL serving cell CRS, the UE may implicitly interpret this as semi-statically indicating that QC assumption is possible between the corresponding DMRS port(s) and the DL serving cell CRS port(s) of the UE (and CSI-RS port(s) to which QC assumption with the DL serving cell CRS port(s) is applied) in performing DMRS-based PDSCH demodulation.", "Thereby, the UE is allowed to perform reception processing in consideration of the QC assumption among the DL serving cell CRS, DMRS and CSI-RS ports.", "In addition, the UE generates CSI to be fed back on the assumption of reception processing subjected to the QC assumption.", "For example, the UE may calculate/determine and report an MCS level, a CQI, an RI, a PMI, and the like with which an error rate less than or equal to 10% can be achieved in performing data demodulation, assuming that the DMRS port(s) has a QC relationship with the DL serving cell CRS port(s) (and CSI-RS port(s) to which QC assumption with the DL serving cell CRS port(s) is applied) on the assumption that the UE receives a DMRS-based PDSCH.", "If all the CSI-RS configurations in a CoMP measurement set are set to be subjected to NQC assumption with the DL serving cell CRS, the UE may implicitly interpret this as semi-statically indicating that NQC assumption between the corresponding DMRS port(s) and the DL serving cell CRS port(s) of the UE is applied in performing DMRS-based PDSCH demodulation.", "In addition, in performing reception processing, the UE should not apply the QC assumption between the CSI-RS port(s) of a CSI-RS configuration and other RS port(s).", "Further, the UE generates CSI to be fed back on the assumption of reception processing subjected to the NQC assumption.", "For example, the UE may calculate/determine and report an MCS level, a CQI, an RI, a PMI, and the like with which an error rate less than or equal to 10% can be achieved in performing data demodulation, assuming that the DMRS port(s) has an NQC relationship with the DL serving cell CRS port(s) on the assumption that the UE receives a DMRS-based PDSCH.", "In another example, when each CSI-RS configuration contains subframe index information, and a DMRS-based PDSCH is scheduled in corresponding subframe(s), whether or not QC/NQC assumption between the DMRS port(s) and the CSI-RS port(s) (and the DL serving cell CRS port(s)) is applied may be indicated through RRC signaling.", "For example, if it is signaled that a QC assumption can be made between CSI-RS1 and the DMRS port(s) in a subframe whose index is an even number, the UE may apply all or some of large-scale properties estimated using CRS port(s)) of CSI-RS1 and/or DL serving cell CRS port(s) to DMRS-based PDSCH reception processing.", "In feeding back CSI, the UE may generate and report both CSI in consideration of QC assumption and CSI in consideration of NQC assumption.", "Alternatively, the UE may calculate/determine and report both a CQI assuming QC and a CQI assuming NQC.", "Such signaling may be provided in the form of a subframe bitmap or a subframe index set.", "For example, subframe set 1 may be configured such that the QC assumption is possible between DMRS port(s) and DL serving cell CRS port(s), and subframe set 2 may be configured such that the QC assumption is possible between DMRS port(s) and specific CSI-RS port(s).", "Alternatively, subframe set 1 may be configured such that the QC assumption is possible between DMRS port(s) and DL serving cell CRS port(s), and subframe set 2 may be configured such that DMRS port(s) and specific CSI-RS port(s) are assumed to be NQC.", "Dynamic Signaling of QC-Related Information Hereinafter, description will be given of examples of the present invention of configuring QC-related information through dynamic signaling.", "For example, the UE may receive DL-related (or downlink grant) DCI about DMRS-based PDSCH transmission through a PDCCH or an EPDCCH.", "The DCI may include information indicating whether or not QC assumption between DMRS port(s) and other RS (e.g., a DL serving cell CRS or CSI-RS of the UE) port(s) is applied.", "As an example of dynamic signaling of QC-related information, only whether or not QC assumption is made between the DMRS port(s) and a specific RS (e.g., the DL serving cell CRS or CSI-RS of the UE) port(s) may be dynamically signaled through information having the size of 1 bit.", "Thereby, if a PDSCH is transmitted, in the manner of dynamic point selection, from a TP for which QC assumption is possible when DL-related DCI for PDSCH scheduling in a manner of CoMP DPS or dynamic cell selection, the eNB may signal, to the UE, that application of QC assumption is possible, thereby improving performance of reception processing of the UE.", "In another example of dynamic signaling of QC-related information, “QC-pair information between a CSI-RS port and a DMRS port” or “QC-pair information between a CRS port and a DMRS port” may be semi-statically pre-configured as information having a plurality of states by higher layer (e.g., RRC layer) signaling, and one of the states may be dynamically indicated when scheduling grant information is provided to the UE through DCI.", "For example, one of N (e.g., N=2) bit states is dynamically triggered, and each of the states corresponds to one of inter-RS QC-pair candidates (e.g., a pair of a CSI-RS and a DMRS and a pair of a CRS and a DMRS) pre-configured by RRC.", "For example, if N=2, states may be pre-configured such that state ‘00’ indicates NQC (namely, DMRS ports are not subject to QC assumption with other RS ports), state ‘01’ indicates that QC assumption with a DL serving cell CRS port is possible, state ‘10’ indicates that QC assumption with a first RRC-configured set of RS (e.g., specific CSI-RS or specific CRS) ports is possible, and state ‘11’ indicates that a second RRC-configured set of RS ports configured by RRC is possible.", "For example, the inter-RS QC-pair of the first RRC-configured set may indicate that “DMRS ports can have QC assumption with CSI-RS port(s) of CSI-RS1 and CSI-RS2”, and the second RRC-configured inter-RS QC-pair may indicate that “DMRS ports can have QC assumption with CRS port(s)”.", "In addition, QC information and CRS rate matching (RM) pattern information may be jointly encoded.", "In this case, the N bit field in the DCI format may be referred to as a “PDSCH RE mapping and QCL indicator field” (or PQI field).", "For example, N (e.g., N=2) bit states may be configured as shown in Table 7 below.", "TABLE 7 QC assumption RM pattern information Flag for QC State with CSI-RS (RM pattern information) assumption with CRS ‘00’ CSI-RS1 CRS-RM1(e.g., PCI1) 1 ‘01’ CSI-RS2 CRS-RM2(e.g., PCI2) 1 ‘10’ CSI-RS3 CRS-RM3(e.g., PCI3) 0 ‘11’ CSI-RS1, CRS-RM1(e.g., PCI1), 1 CSI-RS2 CRS-RM2(e.g., PCI2) In Table 7, the item “QC assumption with CSI-RS” indicates a CSI-RS configuration to which QC assumption with the DMRS port is applicable when information indicating a specific state (‘00’, ‘01’, ‘10’, ‘11’) is included in DL-related DCI for scheduling transmission of a DMRS-based PDSCH.", "For example, it may be assumed that one different CSI-RS per TP is pre-configured for the UE through RRC signaling.", "Herein, a specific TP may be referred to as TPn with an index n (n=0, 1, 2, .", ".", ".", "), a CSI-RS configuration corresponding to TPn may be referred to as CSI-RSn.", "Herein, the term TP may be understood as meaning a cell.", "CSI-RSn may be a CSI-RS configuration of non-zero Tx power (non-zero power (NZP)).", "In this case, state ‘00’ of Table 7 may indicate that QC assumption between CSI-RS port(s) for CSI-RS1 transmitted from TP1 and the DMRS port(s) is possible.", "State ‘01’ may indicate that QC assumption is possible between CSI-RS port(s) of CSI-RS2 transmitted from TP2 and corresponding DMRS port(s), and state ‘10’ may indicate that QC assumption is possible between CSI-RS port(s) of CSI-RS3 transmitted from TP3 and corresponding DMRS port(s).", "That is, the eNB may indicate one of states ‘00’, ‘01’ and ‘10’ through the DL-related DCI, thereby dynamically signaling DPS-wise PDSCH transmission from one of TP1, TP2 and TP3.The item “QC assumption with CSI-RS” of Table 7 may also be signaled, for example, in a manner of informing that the CSI-RS is transmitted from specific TP(s).", "For example, the UE may be informed of a TP transmitting a CSI-RS to which QC assumption with the DMRS is applied, using an identifier (e.g., PCI, VCI, a scrambling sequence seed value, or the like) configured to indicate specific TP(s).", "The item “QC assumption with CSI-RS” may also be used to indicate a specific CSI process.", "In the case of DPS-wise PDSCH transmission, only one CSI process index may be indicated.", "In the case of PDSCH transmission in the JP or joint transmission (JT) scheme, multiple CSI process indexes may be indicated.", "Each CSI process may be associated with a CSI-RS resource for channel measurement and a CSI-interference measurement resource (CSI-IM resource).", "Specifically, one CSI process is defined to be associated with an NZP CSI-RS resource for measurement of a desired signal and an interference measurement resource (IMR) for interference measurement.", "Each CSI process has an independent CSI feedback configuration.", "The independent CSI feedback configuration represents a feedback mode (the type of CSI (RI, PMI, CQI, etc.)", "and a transmission order of CSLs), a periodicity of feedback and a feedback offset.", "When N (N=2) bit information indicating “QC assumption with CSI process” is included in DL-related DCI for scheduling DMRS-based PDSCH transmission as described above, the information may indicate whether QC assumption with the DMRS is applicable for each of the NZP CSI-RS resource and the IMR which are associated with a specific CSI process.", "That is, information indicating whether QC assumption with the DMRS is applicable to both the NZP CSI-RS resource and the IMR, to only the NZP CSI-RS resource, or to only the IMR, or whether both are NQC with the DMRS may be individually provided.", "If QC assumption is applicable between the IMR and the DMRS, this may mean that a parameter (e.g., the value of interference or noise variance) estimated through the IMR is allowed to be utilized to determine a coefficient of a minimum mean squared error (MMSE) filter such as the Wiener filter in the reception processing for DMRS-based demodulation.", "In this case, performance of demodulation of the DMRS may be improved.", "By individually signaling whether or not QC assumption with the DMRS is applicable for each of the NZP CSI-RS and the IMR associated with a CSI process, more accurate channel estimation may be expected.", "For example, when a parameter (e.g., noise variance value) estimated using the IMR is used for reception processing for data demodulation based on the DMRS (e.g., when the parameter is used as a coefficient of an MMSE filter), there may occur an error in single-user (SU)-MIMO transmission or multiple user (MU)-MIMO transmission.", "Specifically, for SU-MIMO transmission, QC assumption with the DMRS is applicable for both the NZP CSI-RS resource and the IMR, and thus it may be expected that data demodulation performance will be improved.", "For MU-MIMO transmission, on the other hand.", "QC assumption with the DMRS is preferably applicable only to the NZP CSI-RS resource and NQC assumption is established between the IMR and the DMRS (namely, a value such as noise variance estimated using the IMR is prohibited from being reused for data demodulation).", "Accordingly, an additional flag bit with the size of 1 bit operatively connected with each state of Table 7 may be defined such that the flag bit indicates only QC assumption between an NZP CSI-RS resource and the DMRS when the flag bit is set to ‘0’, and indicates QC assumption between the DMRS and both the NZP CSI-RS resource and the IMR when the flag bit is set to ‘1’.", "Alternatively, the additional flag bit may be defined such that the flag bit indicates MU-MIMO transmission when set to ‘0’, and indicates SU-MIMO transmission when set to ‘1’.", "Alternatively, the additional flag bit may be defined such that the flag bit indicates, when set to ‘0’, that QC assumption between a CSI process index and the DMRS is disabled (namely, NQC assumption is applied), and indicates, when set to ‘1’, that the QC assumption between the CSI process index and the DMRS is enabled.", "The N bit (e.g., N=2) information and/or the additional flag information with the size of 1 bit which is defined for dynamic signaling of QC information as described above may reuse a format defined in the legacy DCI format, or a new bit field may be additionally defined.", "When the additional flag information with the size of 1 bit is used to switch on/off the QC assumption depending on whether MIMO is SU-MIMO or MU-MIMO, the information may be semi-statically configured as additional information indicated by the N bit information (namely, information which each state of the N bit information pre-represents through RRC signaling), rather than being included in dynamic signaling as a separate bit.", "In the example of Table 7, a TP implementing PDSCH transmission in the DPS scheme (or an RS to which QC assumption with the DMRS is applied) may be indicated as described above.", "Additionally, as in the case of state ‘11’ of Table 7, PDSCH transmission from TP1 and TP2 in the JT scheme may be indicated.", "That is, as in the example of Table 7, the item “QC assumption with CSI-RS” may be signaled as “CSI-RS1, CSI-RS2”, as an identifier corresponding to TP1 and TP2 (e.g., PCI, VCI, or a scrambling sequence seed value), or as “CSI process1, CSI process2”.", "Once the UE acquires such signaling information through DCI, the UE may recognize, through information indicating that QC assumption with TPs is applicable, that DMRS ports will be transmitted from multiple TPs in the form of a virtual DMRS, and may determine estimates of large-scale properties from the TPs by averaging estimates of large-scale properties from the TPs and use the same to improve reception performance.", "In another example, the item “QC assumption with CSI-RS” for a specific state (e.g., state ‘11’ of Table 7) in the N bit information may be set to “non-QC (NQC)” or “not available” or left empty to signal that QC assumption with any TPs should not be applied.", "This may be used to indicate JT.", "For example, in the case of JT, since providing only information about QC assumption with one specific TP may be inappropriate, the NQC state may be signaled.", "If “not available” or empty item is signaled, the NQC state may be implicitly indicated, and as a result no QC assumption may be applied or a certain default state may be applied.", "For example, the default state may be defined as a state in which only QC assumption with a specific DL serving cell RS(s) (e.g., a DL serving cell CRS, a CSI-RS corresponding to a default TP (e.g., a DL serving TP), a CSI-RS belonging to a specific CSI process, etc.)", "can be applied.", "Additionally, as in the example of Table 7, information about a CRS rate matching (RM) pattern which the UE needs to assume upon receiving a corresponding PDSCH may be signaled.", "The information about the CRS RM pattern may include the number of CRS ports, a CRS v-shift (a value of shift in the frequency axis with respect to a basic CRS pattern (see FIG.", "6)), and a subframe set to which the RM pattern is applied.", "The CRS RM pattern refers to configuring PDSCH symbols on the assumption that a PDSCH is mapped to the REs except RE(s) to which a CRS is mapped.", "Accordingly, a terminal that receives the PDSCH can correctly demodulate the PDSCH only when it correctly recognizes a CRS pattern which is considered in rate-matching and transmitting the PDSCH.", "For example, when CRS RM pattern information which TPn transmits is defined as CRS-RMn, state ‘00’ may signal CRS-RM1 representing information about a CRS RM pattern transmitted from TP1, state ‘01’ may signal CRS-RM2 representing information about a CRS RM pattern transmitted from TP2, and state ‘10’ may signal CRS-RM3 representing information about a CRS RM pattern transmitted from TP3.That is, the eNB may indicate one of states ‘00’, ‘01’ or ‘10’, thereby dynamically signaling PDSCH transmission according to DPS from one of TP1, TP2 and TP3.Herein, each CRS RM pattern may be correctly and dynamically indicated in the form of CRS-RMn by providing CRS RM pattern information in addition to “QC assumption with CSI-RS” information, particularly in CoMP scenario 3 (namely, in a situation in which CRSs are simultaneously transmitted from multiple TPs having different cell IDs (i.e., PCIs).", "Each pattern may also be signaled in a manner of informing that the item “RM pattern information” of Table 7 is transmitted from specific TP(s).", "For example, the UE may be informed of a CRS RM pattern by using an identifier (e.g., a PCI, a VCI, or a scrambling sequence seed value, etc.)", "indicating specific TP(s).", "As described above, DPS transmission may be dynamically indicated through state ‘00’, ‘01’ or ‘10’.", "Additionally, as a method for indicating JT from TP1 and TP2 as in the example of state ‘11’ of Table 7, the item “RM pattern information” may be signaled as “CRS-RM1, CRS-RM2”, or an identifier (e.g., PCI, VCI, or scrambling sequence seed value, etc.)", "corresponding to TP1 and TP2 may be indicated.", "The UE having acquired such signaling information through DCI may perform PDSCH demodulation, assuming, for example, that PDSCHs are rate-matched on all REs corresponding to a union of CRS-RM1 and CRS-RM2.That is, if multiple pieces of CRS RM pattern information are indicated by the item “RM pattern information”, the UE receiving the PDSCH may perform PDSCH demodulation, assuming that the PDSCH is not mapped to RE positions indicated by any one of indicated CRS RM patterns (namely, rate-matching is performed during PDSCH transmission).", "Additionally, as in the example of Table 7, the item “Flag for QC assumption with CRS” may include flag indication information indicating whether or not QC assumption can be established between specific CSI-RSn indicated by the item “QC assumption with CSI-RS” and a specific CRS port (i.e., CRS port(s) designated by PCI information) indicated by the item “RM pattern information”.", "Specifically, if a specific state value (e.g., ‘00’, ‘01’, ‘10’, ‘11’) is triggered and the flag bit in the information indicated by the state value is enabled (or is set to ‘1’), this may be defined to indicate that QC assumption can be established between CSI-RS port(s) of CSI-RSn indicated by the state value and CRS port(s) of CRS-RMn indicated by the state value (the CRS port(s) may be known, for example, through PCIn or VCIn which the CRS-RMn indicates).", "If a specific state value (e.g., ‘00’, ‘01’, ‘10’, ‘11’) is triggered and the flag bit in the information indicated by the state value is disabled (or set to ‘0’), this may be defined to indicate that QC assumption should not be established between CSI-RS port(s) of CSI-RSn indicated by the state value and CRS port(s) of CRS-RMn indicated by the state value (the CRS port(s) may be known, for example, through PCIn or VCIn which the CRS-RMn indicates) (namely, an NQC relationship is established).", "Referring to Table 7, states ‘00’ and ‘01’ have “Flag for QC assumption with CRS” set to ‘1’, and thus respectively indicate DPS transmission from TP1 and TP2.Specifically, if the flag bit is set to ‘1’ in state ‘00’, this is interpreted as indicating that QC assumption between CSI-RS1 and DMRS port(s) and QC assumption between CSI-RS1 and PCI1-based CRS port(s) are applicable on the assumption that a PDSCH is rate-matched according to CRS-RM1 pattern.", "If the flag bit is set to ‘1’ in state ‘01’, this is interpreted as QC assumption between CSI-RS2 and DMRS port(s) and QC assumption between CSI-RS2 and PCI2-based CRS port(s) are applicable on the assumption that a PDSCH is rate-matched according to CRS-RM2 pattern.", "If not only applicability of QC assumption between DMRS port(s) and specific CSI-RS port(s) but also applicability of QC assumption between CSI-RS port(s) and specific CRS port(s) (i.e., information indicated by the flag bit of Table 7) is signaled to the UE as above, the UE may be allowed to use not only CSI-RS port(s) to which QC assumption is applicable, but also large-scale channel properties estimated from the CRS port(s) providing a significantly high RS density (namely, more accurate large-scale channel properties) in performing DMRS-based PDSCH demodulation.", "Meanwhile, in the example of Table 7, if “Flag for QC assumption with CRS” corresponding to state ‘10’ is set to ‘0’, which indicates DPS transmission from TP3, this is interpreted as meaning that QC assumption between CSI-RS3 and DMRS port(s) is applicable, but QC assumption between CSI-RS3 and PCI3-based CRS port(s) should not be applied on the assumption that a PDSCH is rate-matched according to CRS-RM3 pattern.", "In the example of Table 7, if “Flag for QC assumption with CRS” corresponding to state ‘11’ is set to ‘1’, which indicates JT transmission from TP1 and TP2, this is interpreted as meaning that QC assumption between CSI-RS1 and PCI1-based CRS port(s) and QC assumption between CSI-RS2 and PCI2-based CRS port(s) are applicable on the assumption that a PDSCH is rate-matched in consideration of both CRS-RM1 and CRS-RM2 patterns.", "If multiple CSI-RSn's are present in the item “QC assumption with CSI-RS” corresponding to a specific state, and CRS-RMn's are present in the item “RM pattern information”, this may be interpreted as meaning that QC-pairs between a CSI-RSn and a CRS-RMn are configured in a predetermined order.", "For example, this case may be interpreted as meaning that QC assumption between CSI-RS1 and CRS-RM1 and QC assumption between CSI-RS2 and CRS-RM2 is applied.", "If the flag bit is set to ‘0’, for example, this may be interpreted as meaning that neither QC assumption between CSI-RS1 and CRS-RM1 nor QC assumption between CSI-RS2 and CRS-RM2 is applied (namely, an NQC relationship is established between the CSI-RSs and the CRS-RMs).", "Alternatively, “Flag for QC assumption with CRS” information may be configured in a manner such that the information individually indicates whether QC/NQC is established between each CSI-RSn and each CRS-RMn.", "As another example of dynamic signaling of QC-related information, N (e.g., N=2) bit states may be configured as shown in Table 8.TABLE 8 QC assumption Flag for QC with RM pattern assumption State CSI-RS) information with CRS Interpretation ‘00’ CSI-RS1 CRS-RM4 0 There is no CRS (e.g., PCI4) port to which QC assumption with CSI-RS1 is applicable (NQC).", "‘01’ CSI-RS2 CRS-RM4 0 There is no CRS (e.g., PCI4) port to which QC assumption with CSI-RS1 is applicable (NQC).", "‘10’ CSI-RS3 CRS-RM3 1 QC assumption (e.g., PCI3) between CSI-RS3 and a PCI3-based CRS port is applicable.", "‘11’ CSI-RS1, No-CRS 0 There is no CRS CSI-RS2 (i.e., MBSFN) port to which QC assumption with CSI-RS1 and CSI-RS2 is applicable (NQC).", "In the example of Table 8, CRS-RM4 (e.g., PCI4) may correspond to CoMP scenario 4, in which TP1 and TP2 share PCI4.In addition, as in the case of state ‘11’ of Table 8, No-CRS (i.e., MBSFN) may be indicated as CRS RM pattern information.", "Referring to FIG.", "3, an MBSFN subframe may represent a subframe in which only a CRS and a control channel (e.g., PDCCH) are transmitted in the control region, and neither the CRS nor the PDSCH is transmitted in the data region.", "To perform scheduling of JT only in MBSFN subframes, No-CRS (i.e., an MBSFN) may be indicated.", "The UE may interpret this indication as meaning that there is no CRS in the data region, and thus may assume that rate matching of the PDSCH is not performed at RE locations corresponding to CRS ports (namely, the PDSCH is mapped to the corresponding REs) in assuming rate matching for the PDSCH.", "The DMRS scrambling seed value x(n) (e.g., n=0, 1) may be implicitly pre-linked or pre-tied (e.g., by RRC signaling) to each state of an N bit-sized field (e.g., a PQI field) described above with reference to Tables 7 and 8.In this case, when a specific one of 2̂N states is indicated by dynamic signaling, a joint encoding scheme may be used, for example, in a manner that a separate dynamic indication parameter (e.g., a scrambling identifier (nSCID)) indicates a value to be used among the values of x(n) linked to the state.", "In the case in which the joint encoding scheme described above is added to the example of Table 7, an example of Table 9 below may be considered.", "TABLE 9 Flag DMRS DMRS QC for QC scrambling scrambling assump- assump- seed x(0) seed x(1) tion with RM pattern tion with tied to tied to State CSI-RS information CRS nSCID = 0 nSCID = 1 ‘00’ CSI-RS1 CRS-RM1 1 315 420 (e.g., PCI1) ‘01’ CSI-RS2 CRS-RM2 1 96 420 (e.g., PCI2) ‘10’ CSI-RS3 CRS-RM3 0 117 420 (e.g., PCI3) ‘11’ CSI-RS1, CRS-RMI 1 480 420 CSI-RS2 (e.g., PCI1), CRS-RM2 (e.g., PCI2) In the example of Table 9, the range of x(n) may be from 0 to 503, which corresponds to the PCI range.", "Table 9 shows exemplary values of x(0) and x(1) allocated to each state.", "For example, 420 may be allocated in common as a value of x(1) linked/tied to nSCID=1.If a specific identifier value to be used in common by multiple TPs is allocated and nSCID=1 is indicated as in this case, using the shared identifier value may be allowed, thereby ensuring DMRS orthogonality between TPs.", "In addition, different values of x(0) linked/tied to nSCID=0 may be allocated to the individual states as in the example of Table 9.Thereby, a TP-specific VCI (or a scrambling seed value) may be used to acquire a cell-splitting gain.", "In addition, a separate VCI (or scrambling seed value) for JT may be designated by allocating a value of x(0) to state ‘11’ such that the value of x(0) for state ‘11’ differs from the values of x(0) for the other states as in the example of Table 9.For example, different values of x(n) may be linked/tied to 2̂N states respectively in an N bit field (e.g., a PQI field) indicating QC information and information about a CRS RM pattern as described above.", "In this case, the value of nSCID to be used to generate a DMRS sequence is dynamically indicated through another filed in the DCI format, and the value of x(n) is implicitly determined according to the value of nSCID.", "For example, a rule may be established such that x(n) (e.g., n=0 or 1) is indicated when nSCID=n.", "For example, when a specific state of the 2̂N states is dynamically indicated, x(0), x(1), and the like linked to the state are determined through joint encoding for x(n).", "Additionally, one of x(0), x(1), and the like is finally determined/selected according to the value of nSCID indicated through a separate field.", "QC Behavior In a legacy system (e.g., a system operating according to a standard prior to 3GPP LTE Release-10 (Rel-10)) that does not support CoMP operation, a behavior of assuming QC between RS ports may be substantially viewed as being implicitly defined.", "In this invention, this behavior may be referred to as Behavior A.", "Behavior A may be defined as a behavior of assuming that a CRS, a CSI-RS and a PDSCH DMRS are QC with respect to at least one of frequency shift, Doppler spread, received timing and delay spread.", "This is because the CRS port, CSI-RS port and the PDSCH DMRS port all naturally need to be assumed to be transmitted from one cell or TP in the legacy system, without considering CoMP operation.", "In a system supporting CoMP operation, another behavior (e.g., a behavior of assuming that CSI-RS1 of TP1 and CSI-RS2 of TP2 are QC) may be defined for QC assumption.", "Accordingly, an embodiment of the present invention proposes that Behavior A be defined as a default behavior in a system to which multiple QC behaviors are applicable.", "That is, the UE may be defined to always operate according to Behavior A, which is the default behavior, if a specific condition is satisfied.", "For example, the UE may be configured to always apply Behavior A to specific CSI process index(s) unless the index is not separately signaled.", "This is intended to ensure the same performance as in the legacy system (Rel-10 system) by allowing the UE to operate according to the same QC assumption as in the legacy system for at least one CSI process when multiple CSI processes are configured for the UE.", "For example, for CSI process index 0, Behavior A may always be applied.", "In this case, a specific CSI-RS resource to which QC assumption with a CRS transmitted from a DL serving cell/TP is applicable in, for example, CoMP scenario 3, may be configured for CSI process index 0.Behavior A, which is the default behavior, may be defined to be applied to transmission modes (e.g., TM9) defined in a legacy system (e.g., a system operating according to a standard prior to 3GPP LTE Rel-10) other than a new transmission mode (e.g., TM10) defined in a CoMP operation-supporting system (e.g., a system conforming to a standard after 3GPP LTE Rel-11).", "A QC behavior applicable to only a system supporting the CoMP operation may be defined as follows.", "In the case in which a DL grant is received through a DCI format (e.g., DCI format 2D) applied to a new transmission mode (e.g., TM10), the UE may assume a new QC behavior (hereinafter, Behavior B).", "Behavior B may be defined as assuming that a CRS, a CSI-RS, and a PDSCH DMRS (and/or an EPDCCH DMRS) are not QC with respect to at least one of delay spread, Doppler spread, Doppler shift, average gain, and average delay, except for the following exception.", "The exception is that a PDSCH DMRS (and/or an EPDCCH DMRS) and a specific CSI-RS resource indicated by physical layer signaling (e.g., signaling through PDCCH DCI) can be assumed to be QC with respect to at least one of the delay spread, the Doppler spread, the Doppler shift, and the average delay.", "That is, Behavior B may be basically configured not to allow QC assumption between a CRS and another RS (e.g., a CSI-RS and a DMRS), and when the DL grant is received through DCI format 2D, QC assumption between CSI-RS port(s) of a specific CSI-RS resource indicated by dynamic signaling as in the examples of Tables 7, 8 and 9 and DMRS port(s) of a PDSCH scheduled by DCI format 2D may be applicable.", "Whether or not QC assumption between a specific CRS and a specific CSI-RS is applicable may also be signaled in the examples of Tables 7, 8 and 9 (or through separate RRC signaling).", "If the DL grant is received through DCI format 2D, QC assumption between a corresponding PDSCH DMRS port and a specific CSI-RS port may be established.", "Additionally, whether or not QC assumption between a specific CSI-RS and a specific CRS is applicable may be configured through RRC signaling.", "In this case, it may be signaled that QC assumption can be established among a DMRS port, a CSI-RS port and a CRS port.", "Behavior B may be given for DCI format 2D, and the UE may perform data demodulation (for example, the UE may reflect large-scale properties estimated through other RSs in determining a Wiener filter coefficient) based on the QC assumption according to Behavior B.", "When Behavior B is applied, a specific CSI-RS, a CRS, and a DMRS are not necessarily from the DL serving cell even if it is indicated that QC assumption has been established among the specific CSI-RS, the CRS, and the DMRS, which is a great difference from Behavior A.", "For example, the CRS may correspond to a CRS port of a neighboring cell rather than the DL serving cell, and one of multiple CSI-RS resources may be indicated for the CSI-RS.", "Regarding frequency offset (or Doppler shift), even if the UE is set to Behavior B, it may be configured to estimate an initial (or coarse) frequency offset based on the serving cell CRS and to estimate a fine frequency offset through an indicated CSI-RS only within a specific frequency range (e.g., [−N; +N] Hz).", "For example, if the transmission periodicity of the CSI-RS is 5 ms, the frequency offset of 200 Hz, which is the reciprocal of 5 ms, may be estimated based on the CSI-RS without ambiguity, and thus the following operation of the UE may be defined.", "The UE may expect, using the CSI-RS as indicated (by Behavior B), that a Doppler shift (and/or Doppler spread) tracked by the UE is within the range of frequency offset (e.g., [−N; +N] Hz) for the serving cell.", "For example, if the periodicity of the indicated CSI-RS is 5 ms, N=100 Hz.", "If the periodicity of the indicated CSI-RS is 10 ms, N=50 Hz.", "If the periodicity of the indicated CSI-RS is 20 ms, N=25 Hz.", "If the periodicity of the indicated CSI-RS is 40 ms, N=12.5 Hz.", "If the periodicity of the indicated CSI-RS is 80 ms, N=6.25 Hz.", "Briefly, if the indicated CSI-RS has a periodicity of T [ms].", "N may be set such that N=1/(kT) [Hz].", "Herein, k may be, for example, 2.The proposed embodiment of the present invention above means that the UE variably determines a frequency range to be searched with respect to the serving cell CRS for estimation of a frequency offset (or a Doppler shift and/or a Doppler spread) as the periodicity of the indicated CSI-RS varies.", "Herein, the indicated CSI-RS may represent one NZP CSI-RS which can establish QC assumption with a DMRS indicated by a DCI (e.g., DCI format 2D) in the case of a UE for which a plurality of CSI-RS resources are configured by a higher layer (e.g., a UE for which TM10 is configured).", "Alternatively, the indicated CSI-RS may be a specific default CSI-RS configured through RRC in the case of DCI format 1A.", "If the periodicity of the CSI-RS is 10 ms, the range for the UE to search is reduced by half of the range for the periodicity of 5 ms. That is, as the CSI-RS periodicity set by the eNB increases, the frequency offset between the CSI-RS and the CRS of a serving cell needs to be set within a narrower range.", "In this case, the UE only needs to estimate the frequency offset within a narrower search range.", "To prevent CSI-RS transmission having a frequency offset out of the search range from causing the UE to incorrectly perform channel estimation and degrading the performance of the UE, the eNB needs to ensure the relationship between the CRS and the CSI-RS as above.", "In view of the eNB, if a frequency offset (or a Doppler shift) between the oscillator of a TP transmitting the CRS and the oscillator of a TP transmitting the indicated CSI-RS is not within a range of [−N; +N] Hz according to N=1/(kT) (e.g., k=2) corresponding to the periodicity of the indicated CSI-RS, T[ms], this may mean that the periodicity of the CSI-RS cannot be set to T [ms].", "In this case, the eNB needs to configure and transmit a CSI-RS having a periodicity set to a value less than T [ms].", "Alternatively, to unify the UE operations, the eNB may be limited to always configure only a CSI-RS having the periodicity of T1 ms (e.g., T1=5) as a CSI-RS to be applied to the case of Behavior B.", "In this case, the UE may expect that the Doppler shift (and/or Doppler spread) tracked by the UE by using the CSI-RS as indicated (Behavior B) is within the range of frequency offset ([−N; +N] Hz with, for example, N=100) with respect to the serving cell, regardless of the indicated periodicity of the CSI-RS.", "Alternatively, the eNB may configure a CSI-RS having a periodicity different from the periodicity of T1 ms, but may set the frequency range for the UE to search to the narrowest range.", "For example, the eNB may configure various CSI-RSs having periodicities of T=5, 10, 20, 40 and 80 ms, such that the value of N always ensures at least the narrowest range (namely, N=6.25 Hz when T=80 ms).", "In this case, the UE may expect that the Doppler shift (and/or Doppler spread) tracked by the UE by using the CSI-RS as indicated (Behavior B) is within the range of frequency offset ([−N; +N] Hz with, for example, N=6.25) with respect to the serving cell, regardless of the indicated periodicity of the CSI-RS.", "If the eNB can configure various CSI-RSs having periodicities of T=5 and 10, N may be set to 50 Hz to ensure the narrowest frequency range of search.", "That is, regardless of the periodicity of the indicated CSI-RS, the UE may only need to perform search within a specific range of [−N; +N] Hz.", "Thereby, the eNB may configure only a CSI-RS having a periodicity ensuring the above operation of the UE such that the UE utilizes the CSI-RS in Behavior B.", "If system performance is lowered or other problems occur in a system to which a new transmission mode (e.g., TM10) is applicable, operation in the default transmission mode needs to be supported for stable operation.", "This mode may be referred to as a fallback operation mode.", "For example, in the case in which a DL grant is received through a fallback DCI format (e.g., DCI format 1A) in MBSFN subframes, the UE may operate according o to Behavior A′ (i.e., a variant of Behavior A).", "Behavior A′ may be defined as assuming that a CRS, a CSI-RS, and a PDSCH DMRS (and/or an EPDCCH DMRS) are not QC with respect to at least one of delay spread, Doppler spread, Doppler shift, average gain, and average delay, except for the following exception.", "The exception may be that a CRS (e.g., a CRS of a DL serving cell or a specific CRS indicated through RRC signaling) and a PDSCH DMRS are assumed to be QC with respect to at least one of the delay spread, the Doppler spread, the Doppler shift, and the average delay.", "That is, Behavior A′ may be basically configured not to allow QC assumption between a CSI-RS and another RS (e.g., a CRS, a DMRS), and when the DL grant is received through DCI format 1A in an MBSFN subframe, QC assumption may be always established between specific CRS port(s) and DMRS port(s) (e.g., DMRS port 7) of a PDSCH scheduled by DCI format 1A.", "In another example, Behavior A′ may be defined such that QC assumption can be additionally established between a specific CSI-RS resource index n (e.g., n=0), a CRS and a DMRS.", "In this case, the scrambling seed value X of the corresponding CSI-RS resource may be restricted to be always a PCI.", "Alternatively, it may be expressed in terms of operation of the UE that the UE is not allowed to expect that CSI-RS resource index n is not identical to the PCI.", "Alternatively, a CSI process (or a specific CSI-RS resource associated with the CSI process) may be used in place of the CSI-RS resource.", "That is, Behavior A′ may be presented as indicating that additional QC assumption can be established between specific CSI process i (e.g., i=0), a CRS and a DMRS.", "When the UE performs data demodulation according to the above assumption, it may apply large-scale channel properties estimated using other RSs to a reception process (by, for example, determining a Wiener filter coefficient based on the properties).", "As Behavior A′ is defined as a separate behavior different from Behavior A or B as above, performance of data demodulation of the UE may be further improved.", "Specifically, DCI format 1A, which corresponds to a fallback DCI format, may be used to ensure clear and robust transmission, for example, in a situation in which ambiguity can occur in a period in which various RRC reconfigurations are applied.", "In a legacy system (e.g., a Rel-10 system), demodulation is defined to be performed through DMRS port 7 when DCI format 1A is received in an MBSFN subframe.", "In performing demodulation, a PCI may be used as a DMRS scrambling seed.", "In this case, QC assumption may be established between a DL serving cell CRS port through which a CRS generated using the PCI is broadcast and a DMRS.", "Accordingly, more accurate large-scale channel properties measured using the CRS can be used in performing data demodulation, thereby improving data demodulation performance.", "Accordingly, Behavior A′ may basically allow QC assumption between a CRS port and a DMRS port.", "In addition, Behavior A′ may provide information indicating that QC assumption can be established between a specific CSI-RS resource index (e.g., CSI-RS resource index 0) or a CSI-RS port belonging to the specific CSI process index (e.g., CSI process index 0) and a DMRS port.", "For example, in CoMP scenario 4, in which multiple TPs use the same cell identifier, CSI-RSs may be simultaneously transmitted from the TPs from which CRSs are simultaneously transmitted (namely, virtual CSI-RSs generated by the PCI may be simultaneously transmitted from a plurality of TPs).", "In other words, Behavior A′ may be understood as being basically similar to Behavior A in that QC assumption can always be established between a CRS and a DMRS, but being different from Behavior A in terms of a method of indicating a CSI-RS to which QC assumption with a DMRS is applicable.", "Specifically, according to Behavior A, a CSI-RS to which QC assumption with a DMRS is applicable may be dynamically indicated through the DCI.", "According to Behavior A′, on the other hand, a CSI-RS to which QC assumption with the DMRS is applicable may be semi-statically indicated through RRC signaling or a specific CSI-RS resource index (e.g., CSI-RS resource index 0) may be statically configured.", "In another example relating to Behavior A′, Behavior A′ may be defined such that QC assumption cannot be established between a CRS and a DMRS, but can be established between a specific CSI-RS resource index (e.g., CSI-RS resource index 0) and the DMRS.", "Behavior A′ defined as above is similar to Behavior B.", "However, according to Behavior B, a CSI-RS resource which can be assumed to be QC with the DMRS is dynamically indicated through the DCI.", "According to Behavior A′, on the other hand, a CSI-RS to which QC assumption with the DMRS is applicable may be semi-statically indicated through RRC signaling or a specific CSI-RS resource index (e.g., CSI-RS resource index 0) may be statically configured.", "In the various examples of Behavior A′ described above, the specific CSI-RS resource index (e.g., CSI-RS resource index 0) may be dynamically indicated as in Behavior B, rather than being statically or semi-statically configured.", "For example, a CSI-RS port belonging to a CSI-RS resource (or a CSI process) to which QC assumption with the DMRS port is applicable may be indicated through a specific field of DCI format 1A detected in an MBSFN subframe (or a UE-specific search space of the MBSFN subframe).", "In this case, Behavior B may be applied in both a case in which the DL grant is received through DCI format 1A in the MBSFN subframe and a case in which the DL grant is received through DCI format 2D.", "Alternatively, Behavior A may be applied in a case in which the DL grant is received through DCI format 1A in the MBSFN subframe and a case in which TMs having indexes lower than that of TM9 (and in this case, the CSI-RS resource may be subject to semi-static RRC signaling or a specific CSI-RS resource index may be statically applied), while Behavior B may be applied only in a case in which the DL grant is received through DCI format 2D.", "Meanwhile, the CSI-RS may be excluded from definition of Behavior A.", "That is, Behavior A may be defined to assume that a CRS and a PDSCH DMRS are QC with respect to at least one of frequency shift, Doppler spread, received timing, and delay spread.", "Excluding QC assumption for the CSI-RS is intended to support a case such as CoMP scenario 4 in which CRSs are simultaneously transmitted from multiple TPs in the form of SFN, but CSI-RSs are not simultaneously transmitted from the TPs in the form of SFN.", "In other words, in Behavior A, estimates of large-scale properties which can aid in performing data demodulation can be sufficiently reflected through QC assumption between the CRS and the DMRS alone, and channel properties measured using the CSI-RS having a lower density than the CRS may not be viewed as greatly improving the performance of DMRS-based data demodulation.", "For this reason, QC assumption between the CSI-RS and the DMRS may be excluded.", "Further, Behavior A excluding the CSI-RS as above may be applied to a case in which no CSI-RS resource is configured for the UE (namely, a TDD system, a reciprocity system, and the like).", "On the other hand, if a CSI-RS resource is configured for the UE, QC assumptions among the CRS, the CSI-RS and the DMRS may be applied according to Behavior A described above.", "Behavior A may be restricted to be applied to only specific TM(s) (e.g., TM1 to TM9 or TM1 to TM8).", "Behavior A depending on whether or not a CSI-RS resource is configured may be expressed as follows.", "Behavior A may be defined to assume that a CRS, a CSI-RS (if configured), and a PDSCH DMRS are QC with respect to at least one of frequency shift, Doppler spread, received timing and delay spread.", "In other words, by assigning a condition of “if configured” to the CSI-RS, Behavior A depending on whether or not the CSI-RS resource is configured may be briefly expressed.", "Further, when details of Behavior A′ are incorporated into Behavior A, Behavior A may be defined as the following.", "Behavior A may be defined as a behavior of assuming that a CRS, a CSI-RS (if only one CSI-RS resource is configured) and a PDSCH DMRS are QC with respect to at least one of frequency shift, Doppler spread, received timing and delay spread.", "In other words, Behavior A may be defined as a behavior of assuming that a CRS, a CSI-RS (if the CSI-RS is configured, and the number of configured CSI-RS resources is 1) and a PDSCH DMRS are QC with respect to at least one of frequency shift, Doppler spread, received timing and delay spread.", "In other words, Behavior A may be defined as a behavior of assuming that a CRS, a CSI-RS (if the CSI-RS is configured, the number of configured CSI-RS resource is 1 (or UE capability P for the maximum number of CSI processes is {1})) and a PDSCH DMRS are QC with respect to at least one of frequency shift, Doppler spread, received timing and delay spread.", "By assigning a condition having the same meaning as “if one CSI-RS resource is configured” to the CSI-RS as above.", "Behavior A depending on whether or not the CSI-RS resource is configured may be briefly expressed.", "Accordingly, when one CSI-RS resource is configured for the UE, QC assumption may be established among the CRS, the CSI-RS and the DMRS.", "If no CSI-RS resource is configured for the UE (as in, for example, the TDD system), or two or more CSI-RS resources are configured for the UE (as in the case of, for example, TM10), QC assumption may be established only between the CRS and the DMRS, while QC assumption with the CSI-RS is not applied.", "If Behavior A is defined to include a case in which QC assumption is excluded for the CSI-RS as above, Behavior A may also be applied to a case in which a DL grant is received through DCI format 1A in an MBSFN subframe in TM10.Behavior B, on the other hand, may be applied only to a case in which the DL grant is received through DCI format 2D in TM10.Among the proposed details above, QC Behavior of the UE in the case in which the DL grant is received through DCI format 1A in an MBSFN subframe may also be applied to a case in which the DL grant is received through DCI format 1A in a non-MBSFN subframe (or only a case in which the DL grant is received through DCI format 1A in the UE-specific search space in a non-MBSFN subframe).", "This is because DMRS-based data demodulation can be defined as in the operation in an MBSFN subframe in the case in which a DL grant is received through DCI format 1A in a non-MBSFN subframe in a new TM (e.g., TM10) (or through DCI format 1A in the UE-specific search space in a non-MBSFN subframe) in a new system (e.g., a system after Rel-11), whereas CRS-based data demodulation is defined in a legacy system (e.g., a system prior to Rel-10) such that CRS-based data demodulation is performed when a DL grant is received through DCI format 1A in a non-MBSFN subframe.", "If DMRS (e.g., DMRS port 7)-based data demodulation is defined, above descriptions of examples of a case in which the DL grant is received through DCI format 1A in an MBSFN subframe may be applied to a case in which the DL grant is received through DCI format 1A in a non-MBSFN subframe.", "Determination of PDSCH Symbol Location In the examples of the present invention described above, description has been given of dynamically indicating information about whether or not QC assumption is applied through an N bit field (e.g., a PQI field) in a DCI format and information associated with PDSCH RE mapping.", "The present invention additionally proposes a method for additionally indicating information associated with a PDSCH start symbol (or data start symbol) (i.e., an OFDM symbol on which mapping of a PDSCH starts) through an N bit field in a DCI format.", "Specifically, 2̂N parameter sets may be configured for the UE by a higher layer, and one of the 2̂N parameter sets may be dynamically signaled through an N bit field (e.g., PQI field) in a DCI format.", "Herein, parameters in one parameter set may include PDSCH start symbol information.", "It is assumed that OFDM symbol indexes of one subframe are given as 0, 1, 2, .", ".", ".", ".", "That is, for a normal CP subframe, the OFDM symbol indexes of the first slot (or a slot having an even-numbered index if the slot index begins with 0) are given as 0, 1, 2, 3, 4, 5, and 6, and the OFDM symbol indexes of the second slot (or a slot having an odd-numbered index if the slot index begins with 0) are given as 7, 8, 9, 10, 11, 12, and 13.For an extended CP, the OFDM symbol indexes of the first slot (or a slot having an even-numbered index) are given as 0, 1, 2, 3, 4, and 5, and the OFDM symbol indexes of the second slot (or a slot having an odd-numbered index) are given as 6, 7, 8, 9, 10, and 11.In usual cases, a PDCCH may be mapped to OFDM symbol indexes from 0 to 1 or 2.The UE may recognize where the PDCCH symbol is through a PCFICH.", "If there is not separate signaling of a PDSCH start symbol index, a symbol index right next to the last PDCCH symbol index determined by the PCFICH is basically determined to be the PDSCH start symbol index.", "In the present invention, a method of signaling PDSCH start symbol information is proposed separately from determination of the location of a PDSCH start symbol based on the PCFICH (i.e., a CFI value).", "For example, the PDSCH start symbol information may be provided according to each of 2̂N states indicated by an N bit field (e.g., a PQI field) in a DCI format indicating the QC assumption-associated information.", "Alternatively, PDSCH start symbol information to be applied to multiple states of the 2̂N states in common may be configured through RRC signaling.", "The present invention proposes that the UE be informed of PDSCH start symbol index information for each subframe pattern (or subframe set).", "There may be at least two subframe sets, and the UE may be pre-informed of configuration of the subframe sets.", "For example, one set including MBSFN subframe(s) and another set including non-MBSFN subframe(s) may be configured.", "In this case, a PDSCH start symbol index applied to the MBSFN subframe and a PDSCH start symbol index applied to the non-MBSFN subframe may be signaled respectively.", "In another example, one PDSCH start symbol index value (e.g., index k) may be provided for each of 2̂N states indicated by an N bit field (e.g., PQI field) in a DCI format (or as information commonly applied to all states through separate RRC signaling).", "Further, a PDSCH start symbol is basically determined according to the signaled value of k, but if k>KThreshold, k=KThreshold may be applied in a specific subframe set (e.g., an MBSFN subframe).", "That is, in a specific subframe, the signaled k may be interpreted as having an upper limit (KThreshold).", "In other words, k=min(KThreshold, K).", "Here, K is a PDSCH start symbol index value applied to a normal subframe, and k is a PDSCH start symbol index that the UE determines in the specific subframe.", "The specific subframe set may be an MBSFN subframe or may be a non-MBSFN subframe.", "In addition, the specific subframe set may represent one subframe set or a plurality of subframe sets.", "For example, if KThreshold=3, it is assumed that a specific state of an N bit field (e.g., a PQI field) in a DCI format indicates k=4.The UE performs PDSCH demodulation considering that the PDSCH start symbol index as signaled is 4 in a non-MBSFN subframe.", "In an MBSFN subframe, the UE interprets k as k=KThreshold=3, thereby performing PDSCH demodulation on the assumption that the PDSCH start symbol index is 3.Herein, KThreshold=3 is but an example, and embodiments of the present invention are not limited thereto.", "KThreshold may be 0, 1, 2, 3, or 4.To summarize the above proposal, the UE may determine, as a PDSCH start symbol index value, one value (indicated by K) of values of RRC-signaled PDSCH start symbol candidates in a normal subframe (e.g., a non-MBSFN subframe) a value determined from a PCFICH of a serving cell in the case of non-cross-carrier scheduling, and a value set by a higher layer in the case of cross-carrier scheduling.", "Herein, the values of RRC-signaled PDSCH start symbol candidates may be 0 or reserved values 1, 2, 3, and 4 (4 is applied only when the system bandwidth corresponds to 10 or fewer PRBs).", "In a specific subframe (e.g., an MBSFN subframe), the PDSCH start symbol index k of the specific subframe (e.g., the MBSFN subframe) is determined as k=min(KThreshold, K) (e.g., KThreshold=2).", "In another example, if the PDSCH start symbol determined as above overlaps another control channel region (e.g., a DL serving cell control channel region), an OFDM symbol next to the control channel region may be determined as the PDSCH start symbol.", "For example, in a non-MBSFN subframe, the greater one of K and a value (i.e., P) determined from the PCFICH of the serving cell in the case of non-cross-scheduling or determined by a higher layer in the case of cross-carrier scheduling may be determined as the PDSCH start symbol (i.e., k) (i.e., k=max{K, P}).", "Herein, K may be set to one of 0, reserved values of 1, 2, 3 and 4 (4 is applied only when the system bandwidth corresponds to 10 or fewer PRBs), a value determined from the PCFICH of a serving cell in the case of non-cross-carrier scheduling, and a value set by a higher layer in the case of cross-carrier scheduling.", "Meanwhile, in an MBSFN subframe indicated by the DCI, the greater one of the least one of KThreshold and K and P (i.e., max{min(KThreshold, K) P}) may be determined as the PDSCH start symbol (i.e., k).", "In another example, the value of K may be determined regardless of determining the PDSCH start symbol from the PCFICH of the serving cell.", "For example, in a non-MBSFN subframe, the greater one of K and P may be determined as the PDSCH start symbol (i.e., k) (i.e., k=max{K, P}).", "Herein, K may be set to one of 0 and reserved values of 1, 2, 3 and 4 (4 is applied only when the system bandwidth corresponds to 10 or less PRBs).", "Meanwhile, in an MBSFN subframe indicated by the DCI, the greater one of the at least one of KThreshold and K and P (i.e., max{min(KThreshold, K), P}) may be determined as the PDSCH start symbol (i.e., k).", "The method of determining the PDSCH start symbol as described above may be limited not to be applied if the number of DwPTS symbols in the configuration of a special subframe in a TDD system is less than or equal to a specific value.", "8 TDD special subframe configurations, for example, may be defined.", "Of the TDD special subframe configurations, configurations having DwPTS symbols whose number is less than or equal to 3 may be configurations #0 and #5 (for details, see TS 36.211).", "In other words, a rule relating to priority between a value determined for the PDSCH start symbol information by RRC signaling and a value determined by DCI signaling may be applied only to special TDD configuration(s) having symbols whose number exceeds a specific symbol number.", "In another example, for a TDD system, TDD special configurations which are scheduled to be applied to the 2̂N states for the DCI signaling respectively may be signaled.", "For example, independent TDD special subframe configuration(s) may be configured for each of 2̂N states by RRC signaling.", "Which of the 2̂N states should be applied to the currently scheduled PDSCH transmission may be dynamically indicated through DCI signaling.", "If a specific state is indicated, and this state indicates a special subframe configuration (e.g., special subframe configuration 6), the UE may override any special subframe configuration of the DL serving cell, and interpret the indicated special subframe configuration as meaning that a PDSCH corresponding to the length of the OFDM symbol is transmitted in the DwPTS region according to the DCI-signaled special subframe configuration, thereby performing PDSCH demodulation according to the interpretation.", "If multiple special subframe configurations are indicated by the DCI, JT transmission may be performed.", "This case may be interpreted as meaning that there is always PDSCH transmission on a DwPTS symbol corresponding to an intersection of the special subframe configurations (namely, an OFDM symbol on which a DwPTS is present in the special subframe configurations in common) or that there is PDSCH transmission on a DwPTS symbol corresponding to a union of the special subframe configurations (namely, an OFDM symbol according to a special subframe configuration having the largest DwPTS region among the special subframe configurations).", "Additionally, PDSCH last symbol (PDSCH ending symbol, data last symbol, or data ending symbol) information may be explicitly signaled.", "In this case, the PDSCH last symbol information may be signaled together with the special subframe configuration(s) according to the 2̂N states of the DCI signaling.", "Alternatively, only the last OFDM symbol information may be signaled without signaling the special subframe configuration(s).", "For example, the UE may determine a DwPTS region through the special subframe configuration(s) indicated through DCI signaling.", "Additionally, if PDSCH last OFDM symbol information is explicitly given, then the UE may determine that a few OFDM symbol(s) in the last portion of the DwPTS region are excluded from the PDSCH region, or more symbols may be included in the PDSCH region than in the DwPTS region.", "That is, given PDSCH last OFDM symbol information, the UE may determine the PDSCH region based on the PDSCH last OFDM symbol even if the special subframe configurations are given through DCI signaling.", "Meanwhile, the UE may assume that special subframe configurations of a DL serving cell are applied and even PDSCH transmission from a neighboring cell/TP other than the serving cell matches the special subframe configurations of the serving cell, rather than signaling the special subframe configurations for 2̂N states indicated by an N bit field (e.g., a PQI field) of a DCI format.", "In other words, it may be defined that the UE can assume that the configurations are the same as the special subframe configurations of the DL serving cell or that the UE is not allowed to expect that a special subframe configuration different from the special subframe configurations of the DL serving cell will be provided.", "Similarly, if a PDSCH is scheduled in a DwPTS of a special subframe, the UE is not allowed to expect that the PDSCH will be transmitted from a cell/a TP other than the DL serving cell of the UE.", "In another example, when a DL grant is transmitted in a special subframe (specifically, in a DwPTS), an N bit field (e.g., PQI field) may not be included in a corresponding DCI format.", "This may mean that a non-CoMP operation is performed and that only PDSCH transmission from the DL serving cell may be scheduled in the special subframe.", "In the various examples of the present invention described above, the range of the last OFDM symbol indexes of the DwPTS region may be signaled to the UE by informing the UE of the special subframe configuration(s) according to the 2̂N states of an N bit field (e.g., PQI field) in the DCI format.", "In addition, signaling for determining a PDSCH start OFDM symbol index may also be provided according to the 2̂N states of the N bit field (e.g., a PQI field) in the DCI format by RRC signaling.", "That is, information indicating the PDSCH start OFDM symbol index and information about a TDD special subframe configuration for determining the PDSCH last OFDM symbol index may be included together in an RRC-configuration parameter set according to each of the 2̂N states.", "Thereby, the UE may determine the PDSCH start symbol and/or PDSCH last symbol included in a parameter set corresponding to a state value indicated through DCI dynamic signaling, thereby correctly performing PDSCH demodulation.", "Application of EPDCCH-Related PQI Parameter QCL information about a DMRS and a CSI-RS, PDSCH RE mapping (or CRS RM pattern (e.g., the number of CRS ports, a CRS frequency shift, a cell identifier, etc.))", "information, information about MBSFN subframe configurations, NZP CSI-RS configuration information, zero-power (ZP) CSI-RS configuration information, TDD special subframe configuration information, PDSCH start symbol information, and/or PDSCH last symbol information may be defined by PQI parameters included in a parameter set (or a parameter list).", "Such parameter set may be referred to as a PQI (PDSCH RE mapping and QCL indicator) parameter set.", "Multiple (e.g., 2̂N) PQI parameter sets may be semi-statically configured by a higher layer.", "Of the 2̂N PQI parameter sets, a certain parameter set may be dynamically indicated by a state value of an N-bit PQI field (hereinafter, referred to as “PQI state value”) in a DCI format (e.g., DCI format 2D).", "In addition, the information about the PQI parameter sets may be semi-statically configured in the form of a separate RRC-configured parameter set, as information for the UE to depend on when the information is scheduled by DCI format 1A.", "Alternatively, a certain PQI parameter set may be configured as default information that the UE should depend on in the case of DCI format 1A.", "A default PQI parameter set may be configured to, for example, match a configuration of a serving cell, or may be separately defined as a default configuration.", "The default PQI parameter set for DCI format 1A may be a parameter set (e.g., a parameter set corresponding to the least PQI state value (e.g., ‘00’)) (e.g., parameter set 1) of a plurality of PQI parameter sets configured for DCI format 2D by a higher layer.", "Scheduling information corresponding to DCI format 1A may be signaled to the UE over an EPDCCH.", "In the case of the EPDCCH, a specific PQI parameter set to be applied to each EPDCCH set may be configured by higher layer signaling.", "The EPDCCH set (or EPDCCH-PRB-set) may represent, for example, a localized EPDCCH mapping RB set or a distributed EPDCCH mapping RB set.", "In the case in which scheduling information corresponding to DCI format 1A is signaled to the UE through an EPDCCH, at least one of the PQI parameters may be pre-configured for each EPDCCH set by, for example, RRC signaling.", "Accordingly, the UE may operate according to some or all of parameters included in an RRC-configured parameter set configured for (or linked or mapped to) each EPDCCH set depending on an EPDCCH set through which DCI format 1A is transmitted to the UE.", "More specifically, the UE may perform blind decoding in a search space for each pre-configured EPDCCH set, and if DCI format 1A is successfully detected as a result of blind decoding, the UE may perform reception processing by reflecting an assumption according to some or all of the parameters included in an RRC-configured parameter set linked to an EPDCCH set describing the search space in PDSCH demodulation scheduled by DCI format 1A.", "Causing the UE to operate according to the PQI parameters configured for each EPDCCH set may be applied only when DCI format 1A is transmitted over the EPDCCH in TM10.If a plurality of EPDCCH sets is configured in TM10, a PQI parameter set may be RRC-configured for each EPDCCH set, and the UE may reflect an assumption according to some or all of the parameters included in an RRC-configured parameter set corresponding to an EPDCCH set in PDSCH demodulation scheduled by DCI format 1A, depending on the EPDCCH set in which DCI format 1A has been detected among the EPDCCH sets.", "On the other hand, for TM1 to TM9, even if a plurality of EPDCCH sets is configured, some or all of the parameters included in the PQI parameter set may be configured to be applied to the EPDCCH sets in common.", "The UE may perform reception processing by reflecting an assumption according to some or all of the parameters included in the PQI parameter set and configured in common in PDSCH demodulation scheduled by DCI format 1A, regardless of the EPDCCH set through which DCI format 1A has been received and decoded.", "While DCI format 1A has been given above as an example in describing embodiments of the present invention in which a PQI parameter set is RRC-configured EPDCCH set-specifically or EPDCCH set-commonly, the embodiments may also be applied to DCI format 2C or 2D.", "In addition, a PQI parameter set for a DCI transmitted through a legacy-PDCCH and a PQI parameter set for a DCI transmitted through an EPDCCH may be independently RRC-configured.", "That is, they may be different from each other since the PQI parameter set mapped to the PQI state value of a DCI transmitted through a legacy-PDCCH is configured independently of the PQI parameter set mapped to the PQI state value transmitted through an EPDCCH.", "An EPDCCH QC behavior may also be defined for each EPDCCH set.", "For example, RRC-configuration may be implemented such that EPDCCH Behavior A or EPDCCH Behavior B is applied to each EPDCCH set.", "Herein, EPDCCH Behavior A is a behavior assuming a QCL relationship between an EPDCCH DMRS and a serving cell CRS.", "EPDCCH Behavior B is a behavior assuming a QCL relationship between the EPDCCH DMRS and a CSI-RS.", "Alternatively, EPDCCH Behavior A may be configured for all EPDCCH sets as a default QC behavior, and EPDCCH Behavior B for a specific CSI-RS may be independently configured for each EPDCCH set.", "The EPDCCH QC behavior will be separately described in detail later.", "Further, not only a QCL behavior but also some or all of PQI parameters may be configured for each EPDCCH set.", "In this case, some or all of the RRC-configured PQI parameter sets may be configured to be applied to decoding of the EPDCCH such that they correspond to 2̂N PQI state values of a DCI.", "For example, if a DCI (e.g., DCI format 2D) is transmitted through a legacy-PDCCH (or an EPDCCH), a PQI parameter set indicated by a specific state value among the PQI state values may be configured for each EPDCCH set such that some or all of parameters of an RRC-configured parameter set are applied to a specific EPDCCH set so as to correspond to the specific PQI state of the DCI.", "In other words, a specific state value of the PQI state values may be designated for each EPDCCH set by RRC configuration.", "In addition, some or all of PQI parameters (QCL information about a DMRS and a CSI-RS, PDSCH RE mapping (or CRS RM pattern (e.g., the number of CRS ports, a CRS frequency shift, a cell identifier etc.))", "information, information about an MBSFN subframe configuration, NZP CSI-RS configuration information, zero-power (ZP) CSI-RS configuration information, TDD special subframe configuration information, PDSCH start symbol information, and/or PDSCH last symbol information) indicated by the specific PQI state value may be applied to EPDCCH decoding.", "For example, RE mapping of the EPDCCH may be determined according to the ZP CSI-RS configuration information, one of the PQI parameters, (on the assumption that the EPDCCH is not mapped to an RE indicated by the ZP CSI-RS), and the EPDCCH may be decoded.", "Alternatively, RE mapping of the EPDCCH may be determined according to the CRS RM pattern information, which is one of the PQI parameters, and the EPDCCH may be decoded.", "Alternatively, whether the subframe in which the EPDCCH is transmitted is an MBSFN subframe or non-MBSFN subframe may be determined according to the MBSFN subframe configuration information, which is one of the PQI parameters, and then whether or not there are RE(s) to which a CRS is mapped may be determined.", "Then, RE mapping of the EPDCCH may be finally determined, and the EPDCCH may be decoded.", "Alternatively, a start symbol of the EPDCCH may be determined based on the PDSCH start symbol information, which is one of the PQI parameters, to determine RE mapping of the EPDCCH and decode the EPDCCH.", "For example, k, the value of the PDSCH start symbol may be determined based on the PDSCH start symbol information included in a PQI parameter set.", "The value of k may be used as the value of the start symbol of the EPDCCH.", "Herein, k indicating the start symbol index of the EPDCCH may be applied to both an MBSFN subframe and a non-MBSFN subframe.", "Alternatively, k may be determined to be equal to K in the non-MBSFN subframe, and be determined to be equal to min(KThreshold, K) in the MBSFN subframe.", "Herein, K may be set to one of 0, reserved values 1, 2, 3 and 4 (4 is applied only when the system bandwidth corresponds to 10 or fewer PRBs), a value determined from the PCFICH of a serving cell in the case of non-cross-carrier scheduling, and a value set by a higher layer in the case of cross-carrier scheduling.", "KThreshold may be, for example, 2.When the PQI parameters include one piece of NZP CSI-RS configuration information, the NZP CSI-RS configuration information may be ignored (or may not be considered) for decoding of the EPDCCH.", "Specifically, if Behavior A or Behavior B is separately RRC-configured for each EPDCCH set, NZP CSI-RS configuration information included in the PQI parameter set for PDSCH demodulation is not applied to decoding of the EPDCCH.", "Alternatively, NZP CSI-RS configuration information may be considered for a specific EPDCCH set indicated by EPDCCH Behavior B.", "The NZP CSI-RS configuration information may optionally be included in the PQI parameter set, and thus description will be given below of each case.", "If one NZP CSI-RS configuration is included in the PQI parameters, this may be considered in determining RE mapping of the EPDCCH and decoding the EPDCCH.", "Specifically, if there is information about one NZP CSI-RS configuration belonging to an RRC-configured PQI parameter set for each EPDCCH set, Behavior B assuming that the EPDCCH DMRS and the NZP CSI-RS are QCL is applied to decoding of the EPDCCH.", "If the configuration information about one NZP CSI-RS is not included in the PQI parameters, Behavior B assuming that the EPDCCH DMRS and a default CSI-RS are QCL is applied to decoding of the EPDCCH.", "Herein, the default CSI-RS may be set to one of a CSI-RS resource assigned the lowest index (e.g., CSI-RS resource index 0), a specific CSI-RS resource (e.g., CSI-RS resource index n, where n has a predetermined value), a CSI-RS resource belonging to the lowest CSI process index (e.g., CSI process index 0) and a CSI-RS resource belonging to a specific CSI process (e.g., CSI process index n, where n has a predetermined value).", "As described above, according to an embodiment of the present invention, a PQI parameter set configured for each of EPDCCH sets (or for all EPDCCH sets in common) by a higher layer may be used to determine RE mapping and EPDCCH antenna port QCL of the EPDCCH.", "Thereby, the performance of encoding the EPDCCH may be improved.", "Priorities in Determining PDSCH Start Symbol The N-bit PQI field in a DCI may have one of 2̂N PQI state values, thereby indicating one of 2̂N PQI parameter sets.", "The 2̂N PQI parameter sets may be pre-configured by a higher layer (e.g., an RRC layer).", "If a specific parameter is not included in a PQI parameter set, a value determined according to a default rule may be applied for the specific parameter.", "For example, if PDSCH start symbol index information is not included in (or given to) a PQI parameter set corresponding to the state value of a specific PQI field, the UE may assume that the PDSCH start symbol index matches the PDSCH start location of the serving cell.", "This means that the UE determines that the location of an EPDCCH start symbol already given through RRC signaling is identical to the location of the PDSCH start symbol rather than determining the PDSCH start symbol based on the PCFICH of the DL serving cell if an EPDCCH start symbol other than the PCI parameter is configured for the UE through separate RRC signaling in the case in which the PDSCH start symbol is not included in the PQI parameters.", "For example, if PDSCH start symbol index information is not included in (or given to) a PQI parameter set corresponding to the state value of a specific PQI field, the UE may determine that the PDSCH start symbol index is a symbol index next to the last symbol index of the PDCCH indicated by the PCFICH of the DL serving cell (namely, PDCCH last symbol index+1).", "Priorities by which the PQI parameters proposed by the present invention are applied are configured as follows.", "The first priority (i.e., an operation that is applied first compared to the other cases) is to operate according to a specific PQI parameter corresponding to a PQI state value when the specific PQI parameter is given.", "The second priority (i.e., an operation that is applied when the operation according to the first priority is not applied), which is applied when a specific PQI parameter corresponding to a PQI state value is not given, is to determine the value of the specific PQI parameter value according to a value, if given, that is separately configured (even for a purpose other than the PQI parameter configuration) in relation to the specific PQI parameter.", "Hereinafter, an operation according to an embodiment of the present invention will be described in relation to the PDSCH start symbol information, which is one of the PQI parameters.", "In order to determine whether to apply the operation according to the first priority or the operation according to the second priority, it is determined whether a PDSCH start symbol value is included in (or given to) a PQI parameter set corresponding to a specific state value of the PQI field in the DCI.", "As the operation according to the first priority, if a PDSCH start symbol value is provided by a PQI parameter set corresponding to a specific state value of the PQI field in the DCI, the UE may perform PDSCH demodulation (or EPDCCH decoding) using the PDSCH start symbol value.", "Herein, PDSCH start symbol information (e.g., information represented by K in the above examples) that is RRC-signaled with respect to a non-MBSFN subframe may be one of 0, reserved values of 1, 2, 3 and 4 (4 is applied only when the system bandwidth corresponds to 10 or less PRBs), a value determined from the PCFICH of a serving cell in the case of non-cross-carrier scheduling, and a value set by a higher layer in the case of cross-carrier scheduling.", "Alternatively, K may be set to one of 0, reserved values of 1, 2, 3 and 4 (4 is applied only when the system bandwidth corresponds to 10 or fewer PRBs), a value determined from the PCFICH of a specific cell or TP in the case of non-cross-carrier scheduling, and a value set by a higher layer in the case of cross-carrier scheduling.", "Herein, the method of dynamically determining the number of PDSCH start symbols according to the information (or another parameter/value/variable indicating the number of OFDM symbols in the control region) given by the PCFICH of the specific cell or TP may be applied if an RE (e.g., CRS, CSI-RS, tracking RS, etc.)", "of the specific cell or TP can be reliably detected (by, for example, a UE having an interference cancellation receiver).", "The above operation of dynamically determining the PDSCH start symbol K according to the PCFICH of a specific cell or TP may also be applied to other embodiments for preventing the DL control channel region and the PDSCH region from overlapping.", "For example, in a non-MBSFN subframe, the PDSCH start symbol value k may be determined to be max{K, P}.", "In an MBSFN subframe, the PDSCH start symbol value k may be determined to be max{(min(KThreshold, K)).", "Herein, K may be set to one of 0, reserved values 1, 2, 3 and 4 (4 is applied only when the system bandwidth corresponds to 10 or fewer PRBs), a value determined from the PCFICH of a specific cell or TP in the case of non-cross-carrier scheduling, and a value set by a higher layer in the case of cross-carrier scheduling.", "P may be set to a value determined from the PCFICH of a serving cell in the case of non-cross-scheduling or a value set by a higher layer in the case of cross-carrier scheduling.", "KThreshold may be, for example, 2.As the operation according to the second priority, if a PDSCH start symbol value is not provided by a PQI parameter set corresponding to a specific state value of the PQI field in the DCI, but there is a PDSCH start symbol value separately configured (even for a purpose other than the PQI parameter configuration), the UE may perform PDSCH demodulation (or EPDCCH decoding) using the separately configured value.", "For example, the PDSCH start symbol configured separately from the PQI parameter may be information for indicating an EPDCCH start symbol value.", "In other words, it may be determined that EPDCCH start symbol=PDSCH start symbol.", "To this end, if EPDCCH start symbol information is semi-statically configured in the UE, the UE may determine a PDSCH start symbol according to the information and perform PDSCH demodulation.", "As another example, even when the PDSCH start symbol information of the DL serving cell is not provided, the UE may perform PDSCH demodulation if there is PDSCH start symbol information configured for another cell or TP (e.g., a cell or TP which transmits a PDSCH through QC information about the CSI-RS).", "This may be interpreted as being similar to providing PDSCH start symbol information of an SCell through RRC signaling in a carrier aggregation (CA) system.", "Herein, the SCell may be viewed as a neighboring TP in a CoMP measurement set in the same frequency band.", "For example, there may be a case in which DCI format 1A is used to perform fallback operation.", "In this case, information for an operation mode such as the CoMP mode (particularly, information about a PDSCH start symbol) may not be provided.", "Alternatively, when a DCI for scheduling a PDSCH for the CoMP mode is given, if the DCI is transmitted in the common search space in which the UE attempts to detect a scheduling message together with other UEs, the DCI may not include PDSCH start symbol information in order to maintain the same length as that of other scheduling information.", "If a PDSCH is scheduled by scheduling information not containing information about the PDSCH start symbol as in this case, the EPDCCH and the PDSCH may have the same start point on the same cell (or CC).", "As the operation according to the third priority, if no PQI parameter is given, nor is there a value configured for other purposes, the PDSCH start symbol index may be determined to be a symbol index next to the last symbol index of the PDCCH indicated by the PCFICH of the DL serving cell (namely, PDCCH last symbol index+1), as a method to support the most basic operation.", "In another example, the greatest value which can be indicated by CFI of the PCFICH plus 1 (i.e., PDCCH maximum span+1) may be determined as the value of the PDSCH start symbol index.", "In the case of the method of determining PDCCH maximum span+1 as the value of the PDSCH start symbol index, resource availability may be degraded when the PDCCH uses fewer symbols than the maximum span.", "However, this method has an advantage of simplifying and stabilizing the operation of the UE.", "For example, the number of OFDM symbols which can be used for the PDCCH may be defined as shown in Table 10 below.", "In this case, when the downlink system bandwidth corresponds to 10 or fewer RBs (i.e., NRBDL≤10), the maximum number of OFDM symbols for the PDCCH is 4.Accordingly, the PDSCH start symbol may be determined to be the 5th OFDM symbol (or symbol index 4 when the OFDM symbol index starts from 0).", "TABLE 10 Number of Number of OFDM OFDM symbols symbols for PDCCH for PDCCH Subframe when NRBDL > 10 when NRBDL ≤ 10 Subframes 1 and 6 for frame 1, 2 2 structure type 2 MBSFN subframes on a carrier 1, 2 2 supporting PDSCH, configured with 1 or 2 cell-specific antenna ports MBSFN subframes on a carrier 2 2 supporting PDSCH, configured with 4 cell-specific antenna ports Subframes on a carrier not 0 0 supporting PDSCH Non-MBSFN subframes (except 1, 2, 3 2, 3 subframe 6 for frame structure type 2) configured with positioning reference signals All other cases 1, 2, 3 2, 3, 4 In another example, in Table 10, the greatest value may be determined among the values indicated by the CFI (namely, the number of OFDM symbols) under given conditions such as a frame structure, whether a subframe is an MBSFN subframe or a non-MBSFN subframe, and the number of CRS antenna ports, and a symbol index corresponding to the determined greatest value plus 1 may be determined as the position of the PDSCH start symbol.", "The greatest value satisfying the above conditions may be determined to be the greatest value in a specific row or a specific column in Table 10.In another example, PDSCH start symbol position information of a cell or TP other than the DL serving cell may be used.", "For example, the cell or TP may be a cell or TP that transmits PDSCH according to QC information about a CSI-RS.", "When a specific signature value (e.g., a scrambling seed value such as a physical cell identifier and a virtual cell identifier) for the cell or TP is indicated, if the PCFICH can be decoded through an RS (e.g., a CRS, tracking RS, a CSI-RS, etc.)", "of the cell or TP, then a symbol index next to the last symbol index of the PDCCH determined according to a CFI value indicated by the PCFICH may be determined to be the location of the PDSCH start symbol.", "In an additional example, if the UE receives specific PDSCH scheduling information (e.g., information about downlink scheduling through a specific DCI format), a cell to transmit the PDSCH may be predetermined to be a specific cell other than the serving cell of the UE.", "In this case, what the predetermined specific cell is may be configured by a higher layer (e.g., the RRC layer).", "If the PDSCH is scheduled by a DCI transmitted through the PDCCH rather than the EPDCCH, this may correspond to a case in which information about the EPDCCH start symbol is different from the information about the PDSCH start symbol or there is no information about the EPDCCH start symbol.", "In this case, the PDSCH start symbol value separately configured in the second priority cannot be used, and therefore the location of the PDSCH start symbol may be determined according to the third priority.", "Application of PQI Parameter to PDSCH Scheduled in Fallback Mode When reconfiguration of the transmission mode is performed with respect to the UE, the operation mode of the eNB may be inconsistent with that of the UE.", "In this case, both the UE and the eNB may operate in the fallback mode, which is basically supported, in order to ensure stable operation.", "In this embodiment, it is proposed that a PQI parameter be applied to a PDSCH scheduled in the fallback mode.", "When operation is performed in the fallback mode, an operation according to the first priority (e.g., an operation performed in the case in which the PDSCH start symbol information is directly given) may not be applied.", "Herein, when the UE and the eNB operate in the fallback mode, if the operation according to the first priority cannot be applied, an operation according to the second priority (e.g., the operation of determining the location of the PDSCH start symbol according to the EPDCCH start symbol information) may not be performed, but an operation according to the third priority (e.g., the operation of determining a symbol index next to the PDCCH last symbol index determined by a CFI value indicated by the PCFICH as the location of the PDSCH start symbol) may be performed.", "For example, the start symbol location of PDSCH transmission scheduled by a DCI format for the fallback mode (e.g., DCI format 1A) may be configured to be different from that of the EPDCCH start symbol of the same cell (CC) in order to ensure more stable fallback operation.", "For example, in the case in which a PDSCH is scheduled according to DCI format 1A for the fallback mode, the PDSCH may be designated as a PDSCH transmitted from a predetermined specific cell (e.g., a serving cell of the UE).", "This is because it is appropriate in the fallback mode to allow the serving cell to manage operation of the UE.", "In this case, the start symbol location of the PDSCH scheduled according to DCI format 1A is preferably configured to be identical to the PDSCH start symbol location of the serving cell.", "Thereby, if the PDSCH is scheduled according to DCI format 1A, the UE may determine the PDSCH start symbol location according to a value indicated by the CFI of the PCFICH of the serving cell regardless of the start symbol location of a separately RRC-configured EPDCCH.", "Alternatively, PDSCH start symbol information of the serving cell may be provided through higher layer signaling (e.g., RRC layer signaling) and operation may be performed according to the information.", "Herein, the PDSCH start symbol information of the serving cell indicated by a higher layer signal may be given as a PDSCH start symbol location to be applied when the PDSCH is scheduled according to DCI format 1A or as a PDSCH start symbol location to be used when the PDSCH can be assumed to be transmitted from the same location as that of a specific RS (e.g., a CRS or a specific reference CSI-RS) of the serving cell.", "Herein, the reference CSI-RS may be implicitly assumed to be transmitted by the serving cell, and correspond to a specific CSI-RS configuration index such as the first (or lowest) CSI-RS configuration index.", "In addition, even when a PDSCH scheduling message is detected in the common search space (CSS), and the information about the PDSCH start symbol location is not contained in the PDSCH scheduling message, operation may be performed in a similar manner.", "In other words, in the case of DCI format 1A transmitted in the CSS in a non-MBSFN subframe, CRS-based operation needs to be performed to provide the fallback operation that ensures the same operation in all transmission modes, it is preferable to ensure that the PDSCH start symbol location is determined according to the PCFICH information of the serving cell.", "To summarize the above proposal, the operation of the UE according to a first embodiment of the present invention relating to application of a PQI parameter in the fallback mode may be defined as follows.", "If a PDSCH is scheduled according to DCI format 1A in the CSS in a non-MBSFN subframe, the start symbol of the PDSCH is determined based on PCFICH information (i.e., CFI) of the DL serving cell.", "If a PDSCH is scheduled according to DCI format 1A in a UE-specific search space in an MBSFN subframe or a non-MBSFN subframe, the start symbol of the PDSCH is determined according to a PQI parameter matching a predetermined one of PQI state values configured for DCI format 2D.", "Herein, DCI format 2D exemplarily refers to a DCI format including a PQI field.", "In addition, the predetermined one of the PQI state values represents a default PQI state value, and may be defined as, for example, the first PQI state value or the lowest PQI state value.", "As a second embodiment of the present invention relating to application of a PQI parameter in the fallback mode, a UE operation may be defined so as to allow operation in the fallback mode even when a PDSCH is scheduled by a DCI transmitted in the UE-specific search space in a non-MBSFN subframe.", "Thereby, the UE operation may be defined for the case of the MBSFN subframe and the non-MBSFN subframe as follows.", "If a PDSCH is scheduled according to DCI format 1A in a non-MBSFN subframe, the start symbol of the PDSCH is determined based on PCFICH information (i.e., CFT) of the DL serving cell.", "If a PDSCH is scheduled according to DCI format 1A in an MBSFN subframe, the start symbol of the PDSCH is determined according to a PQI parameter matching a predetermined one of PQI state values configured for DCI format 2D.", "Herein, DCI format 2D exemplarily refers to a DCI format including a PQI field.", "In addition, the predetermined one of the PQI state values represents a default PQI state value, and may be defined as, for example, the first PQI state value or the least PQI state value.", "It has been proposed, in the exemplary embodiments of the present invention described above, that the PDSCH start symbol should be determined based on PCFICH information (i.e., the CFI) of the serving cell when PDSCH demodulation is performed based on the CRS.", "In the case of TM10, when a PDSCH is scheduled according to DCI format 1A in a non-MBSFN subframe as in the case of TM9, if CRS-based PDSCH transmission (e.g., antenna port 0 transmission or transmit diversity mode) is performed regardless of whether DCI format 1A is detected in the common search space or the UE-specific search space, the PQI parameter may not be applied as described above in the second embodiment of the present invention relating to application of the PQI parameter in the fallback mode, but the PDSCH start symbol may be determined based on the PCFICH information (i.e., the CFI) of the serving cell.", "Meanwhile, DCI format 1A transmitted through an EPDCCH in a non-MBSFN subframe is transmitted only in the UE-specific search space.", "Accordingly, as described above in the first embodiment relating to application of a PQI parameter in the fallback mode, the PDSCH start symbol of a PDSCH scheduled according to DCI format 1A received through the common search space in a non-MBSFN subframe may be determined based on the PCFICH information (i.e., the CFI) of the serving cell, while a PQI parameter corresponding to a specific PQI state value may be applied to a PDSCH scheduled according to another DCI format 1A.", "Regarding the first and second embodiments of the present invention relating to application of a PQI parameter in the fallback mode, UE operations according to an additional embodiment performed depending on whether DCI format 1A is transmitted over an EPDCCH or a PDCCH may be defined as follows.", "A variation of the first embodiment relating to application of a PQI parameter in the fallback mode may be defined as follows.", "If a PDSCH is scheduled according to DCI format 1A transmitted through an EPDCCH in the common search space in a non-MBSFN subframe, the start symbol of the PDSCH is determined according to the EPDCCH start symbol.", "Herein, the EPDCCH start symbol may be determined based on the PCFICH information (i.e., the CFI) of the serving cell, or determined according to an RRC-configured EPDCCH start symbol value.", "If a PDSCH is scheduled according to DCI format 1A transmitted through a PDCCH in the common search space in a non-MBSFN subframe, the start symbol of the PDSCH is determined based on the PCFICH information (i.e., the CFI) of a DL serving cell.", "If a PDSCH is scheduled according to DCI format 1A in the UE-specific search space in an MBSFN subframe or a non-MBSFN subframe, the start symbol of the PDSCH is determined according to a PQI parameter matching a predetermined one of PQI state values configured for DCI format 2D, regardless of whether transmission is performed through the PDCCH or the EPDCCH.", "Herein, DCI format 2D exemplarily refers to a DCI format including a PQI field.", "In addition, the predetermined one of the PQI state values represents a default PQI state value, and may be defined as, for example, the first PQI state value or the lowest PQI state value.", "A variation of the second embodiment relating to application of a PQI parameter in the fallback mode may be defined as follows.", "If a PDSCH is scheduled according to DCI format 1A transmitted through an EPDCCH in a non-MBSFN subframe, the start symbol of the PDSCH is determined according to the EPDCCH start symbol.", "Herein, the EPDCCH start symbol may be determined based on the PCFICH information (i.e., the CFI) of the serving cell, or determined according to an RRC-configured EPDCCH start symbol value.", "If a PDSCH is scheduled according to DCI format 1A transmitted through a PDCCH in a non-MBSFN subframe, the start symbol of the PDSCH is determined based on the PCFICH information (i.e., the CFI) of a DL serving cell.", "If a PDSCH is scheduled according to DCI format 1A in an MBSFN subframe, the start symbol of the PDSCH is determined according to a PQI parameter matching a predetermined one of PQI state values configured for DCI format 2D regardless of whether transmission is performed through the PDCCH or the EPDCCH.", "Herein, DCI format 2D exemplarily refers to a DCI format including a PQI field.", "In addition, the predetermined one of the PQI state values represents a default PQI state value, and may be defined as, for example, the first PQI state value or the lowest PQI state value.", "The various embodiments of the present invention relating to a method for determining the PDSCH start symbol in the fallback mode (e.g., when the PDSCH is scheduled according to DCI format 1A) described above may be similarly applied to the operation of determining a CRS RM (Rate Matching) pattern (e.g., the number of CRS ports, CRS frequency shift information, MBSFN configuration information, etc.).", "This serves to eliminate ambiguity and promote stability by determining the PDSCH start symbol according to the PCFICH information (i.e., the CFI) of a serving cell in the case of CRS-based PDSCH transmission (e.g., antenna port 0 transmission or transmit diversity mode) scheduled according to fallback mode DCI format 1A.", "Accordingly, it is appropriate to determine PDSCH RE mapping according to the CRS RM pattern of the serving cell for the same purpose.", "That is, a PQI parameter (e.g., PDSCH start symbol information, CRS RM pattern, etc.)", "corresponding to a specific PQI state value (e.g., the first PQI state value or the lowest PQI state value) configured for DCI format 2D is preferably applied only to PDSCH transmission (e.g., DMRS-based PDSCH transmission) other than CRS-based PDSCH transmission (e.g., antenna port 0 transmission or transmit diversity mode).", "When the CRS RM pattern is determined in this way, PDSCH RE mapping may be correspondingly determined.", "Herein, demodulation of a PDSCH transmitted based on the CRS may be performed using a part of the PQI parameter, and the other parameters may match information of the serving cell.", "For example, only information about ZP CSI-RS configuration and/or PDSCH start symbol may be applied to demodulation of the PDSCH transmitted based on the CRS among the parameters included in the PQI parameter set, and information about the CRS RM pattern may not be applied (namely, the CRS RM pattern may match the information of the serving cell).", "Corresponding UE operations may be defined as follows.", "If a PDSCH is scheduled according to DCI format 1A in the common search space in a non-MBSFN subframe, the CRS RM pattern is determined based on the CRS RM pattern information of the DL serving cell.", "Herein, the CRS RM pattern information of the serving cell may include, for example, the number of CRS ports of the serving cell, CRS frequency shift of the serving cell, and an MBSFN subframe configuration of the serving cell.", "If a PDSCH is scheduled according to DCI format 1A in the UE-specific search space in an MBSFN subframe or a non-MBSFN subframe, the CRS RM pattern is determined based on a parameter associated with the CRS RM pattern among the PQI parameters depending on a predetermined one of PQI state values configured for DCI format 2D.", "Herein.", "DCI format 2D refers to a DCI format including a PQI field.", "In addition, the predetermined one of the PQI state values represents a default PQI state value, and may be defined as, for example, the first PQI state value or the lowest PQI state value.", "In addition, the parameter associated with the CRS RM pattern among the PQI parameters corresponds to the number of CRS ports (e.g., 1, 2, 4, or reserved value), CRS frequency shift, and an MBSFN subframe configuration.", "According to an embodiment of the present invention relating to determination of the CRS RM pattern, in order to ensure operation in the fallback mode in the case in in which a PDSCH is scheduled according to DCI transmitted in the UE-specific search space in a non-MBSFN subframe, the following UE operations may be defined.", "Thereby, UE operations may be defined separately according to the MBSFN subframe and the non-MBSFN subframe respectively.", "If a PDSCH is scheduled according to DCI format 1A in a non-MBSFN subframe, the CRS RM pattern is determined based on the CRS RM pattern information of the DL serving cell.", "Herein, the CRS RM pattern information of the serving cell may include, for example, the number of CRS ports of the serving cell, CRS frequency shift of the serving cell, and an MBSFN subframe configuration of the serving cell.", "If a PDSCH is scheduled according to DCI format 1A in an MBSFN subframe, the CRS RM pattern is determined based on a parameter associated with the CRS RM pattern among the PQI parameters depending on a predetermined one of PQI state values configured for DCI format 2D.", "Herein, DCI format 2D exemplarily refers to a DCI format including a PQI field.", "In addition, the predetermined one of the PQI state values represents a default PQI state value, and may be defined as, for example, the first PQI state value or the lowest PQI state value.", "In addition, the parameter associated with the CRS RM pattern among the PQI parameters corresponds to the number of CRS ports (e.g., 1, 2, 4, or reserved value), CRS frequency shift, and an MBSFN subframe configuration.", "According to a variation of the embodiment, regardless of the subframe type (e.g., MBSFN or non-MBSFN) and the search space type (e.g., common search space or UE-specific search space), if a PDSCH is scheduled according to DCI format 1A, the UE may operate according to a PQI parameter corresponding to a predetermined one (e.g., the lowest PQI state value) of the PQI state values configured for DCI format 2D.", "If a CRS-based PDSCH is scheduled, however, the UE may not be allowed to expect that PDSCH start symbol information and/or CRS RM pattern information, which are PQI parameters, will be RRC-configured according to information of a cell other than the serving cell.", "Corresponding UE operations may be summarized as follows.", "First, a UE operation for the CRS RM information may be defined as follows.", "If a PDSCH is scheduled according to DCI format 1A in a non-MBSFN subframe, the UE is not allowed to expect that a parameter associated with the CRS RM pattern indicated by a predetermined one of the PQI state values configured for DCI format 2D will differ from the CRS RM information of the serving cell of the UE.", "Herein, DCI format 2D refers to a DCI format including a PQI field.", "In addition, the predetermined one of the PQI state values represents a default PQI state value, and may be defined as, for example, the first PQI state value or the lowest PQI state value.", "In addition, the parameter associated with the CRS RM pattern among the PQI parameters corresponds to the number of CRS ports (e.g., 1, 2, 4, or reserved value), CRS frequency shift, and an MBSFN subframe configuration.", "The above UE operation may be expressed as follows.", "When the UE set to TM10 receives a PDSCH demodulated through ports 0 to 3, the UE may assume that the number of CRS ports in a PQI state defining RE mapping of the PDSCH, v-shift (or frequency shift), and MBSFN subframe configuration information as given are identical to those of the serving cell.", "Herein, ports 0 to 3 represent CRS antenna port indexes.", "Next, a UE operation for the PDSCH start symbol information may be defined as follows.", "If a PDSCH is scheduled according to DCI format 1A in a non-MBSFN subframe, the UE is not allowed to expect that PDSCH start symbol information indicated by a predetermined one of the PQI state values configured for DCI format 2D will differ from the PDSCH start symbol information of the serving cell of the UE.", "Herein, DCI format 2D refers to a DCI format including a PQI field.", "In addition, the predetermined one of the PQI state values represents a default PQI state value, and may be defined as, for example, the first PQI state value or the lowest PQI state value.", "The above UE operation may be expressed as follows.", "When the UE set to TM10 receives a PDSCH demodulated through ports 0 to 3, the UE may assume that the start symbol information of a PQI state defining the start symbol of the PDSCH as given is identical to that of the serving cell.", "Herein, ports 0 to 3 represent CRS antenna port indexes.", "According to another variation of the embodiment, if a PDSCH is scheduled according to DCI format 1A, the UE may operate according to a PQI parameter corresponding to a predetermined one (e.g., the lowest PQI state value) of the PQI state values configured for DCI format 2D.", "If a PDSCH is scheduled according to DCI format 1A transmitted in the common search space in a non-MBSFN subframe, the UE may not be allowed to expect that PDSCH start symbol information and/or CRS RM pattern information, which are PQI parameters, will be RRC-configured according to information of a cell other than the serving cell.", "Corresponding UE operations may be summarized as follows.", "First, a UE operation for the CRS RM information may be defined as follows.", "If a PDSCH is scheduled according to DCI format 1A in the common search space in a non-MBSFN subframe, the UE is not allowed to expect that a parameter associated with the CRS RM pattern indicated by a predetermined one of the PQI state values configured for DCI format 2D will differ from the CRS RM information of the serving cell of the UE.", "Herein, DCI format 2D refers to a DCI format including a PQI field.", "In addition, the predetermined one of the PQI state values represents a default PQI state value, and may be defined as, for example, the first PQI state value or the lowest PQI state value.", "In addition, the parameter associated with the CRS RM pattern among the PQI parameters corresponds to the number of CRS ports (e.g., 1, 2, 4, or reserved value), CRS frequency shift, and an MBSFN subframe configuration.", "Next, a UE operation for the PDSCH start symbol information may be defined as follows.", "If a PDSCH is scheduled according to DCI format 1A in the common search space in a non-MBSFN subframe, the UE is not allowed to expect that PDSCH start symbol information indicated by a predetermined one of the PQI state values configured for DCI format 2D will differ from the PDSCH start symbol information of the serving cell of the UE.", "Herein, DCI format 2D refers to a DCI format including a PQI field.", "In addition, the predetermined one of the PQI state values represents a default PQI state value, and may be defined as, for example, the first PQI state value or the lowest PQI state value.", "PDSCH QCL Behavior and EPDCCH QCL Behavior In the above description of various proposed embodiments of the present invention, Behavior A and Behavior B have been defined as QC behaviors (or PDSCH QCL behaviors) for a PDSCH.", "To summarize the behaviors, PDSCH QCL Behavior A is a behavior of assuming a QCL relationship among a serving cell CRS, a CSI-RS and a PDSCH DMRS, and PDSCH QCL Behavior B is a behavior of assuming a QCL relationship between a CSI-RS (e.g., a CSI-RS which is QCL with a CRS of a specific cell) and a PDSCH DMRS.", "In the above description of various proposed embodiments of the present invention, Behavior A and Behavior B have been defined as QC behaviors (or EPDCCH QCL behaviors) for an EPDCCH.", "To summarize the behaviors, EPDCCH QCL Behavior A is a behavior of assuming a QCL relationship between an EPDCCH DMRS and a serving cell CRS, and EPDCCH QCL Behavior B is a behavior of a QCL relationship between an EPDCCH DMRS and a CSI-RS.", "According to an additional embodiment of the present invention, EPDCCH QCL Behavior A and EPDCCH QCL Behavior B may be configured with a restriction depending on a PDSCH QCL behavior that is RRC-configured.", "For example, if the UE is configured for PDSCH QCL Behavior A (i.e., QCL among a serving cell CRS, a CSI-RS and a DMRS), EPDCCH QCL Behavior A (i.e., QCL between a serving cell CRS and an EPDCCH DMRS) may be automatically configured.", "In other words, if the UE is configured for PDSCH QCL Behavior A, the EPDCCH QCL behavior should be configured only as EPDCCH QCL Behavior A.", "In other words, if the UE is configured for PDSCH QCL Behavior A, the UE is not allowed to expect that EPDCCH QCL Behavior B (i.e., QCL between a CSI-RS and an EPDCCH DMRS) will be configured.", "If the UE is configured for PDSCH QCL Behavior A, information about an NZP CSI-RS configuration intended for QCL may not be included in the PQI parameters.", "Thereby, when EPDCCH QCL Behavior B is configured, the UE cannot identify a CSI-RS with which the EPDCCH DMRS is QCL.", "Accordingly, if the UE is configured for PDSCH QCL Behavior A, it is appropriate to configure EPDCCH QCL Behavior A in order to eliminate such ambiguity.", "For a similar purpose, when EPDCCH Behavior A is configured, PDSCH Behavior A may be configured.", "In another example, if the UE is configured for PDSCH QCL Behavior B (i.e., QCL between a CSI-RS and a DMRS), EPDCCH QCL Behavior B (i.e., QCL between a CSI-RS and an EPDCCH DMRS) may be automatically configured.", "In other words, if the UE is configured for PDSCH QCL Behavior B, the EPDCCH QCL behavior should be configured only as EPDCCH QCL Behavior B.", "In other words, if the UE is configured for PDSCH QCL Behavior B, the UE is not allowed to expect that EPDCCH QCL Behavior A (i.e., QCL between the serving cell CRS and the EPDCCH DMRS) will be configured.", "This is intended to maintain unity of a PDSCH QCL behavior and an EPDCCH QCL behavior.", "Similarly, if EPDCCH Behavior B is configured, PDSCH Behavior B may be configured.", "In other words, restrictions may be applied such that both the PDSCH QCL behavior and the EPDCCH QCL behavior are configured as QCL Behaviors A or as QCL Behaviors B.", "That is, the PDSCH QCL behavior and the EPDCCH QCL behavior may be RRC-configured so as to be connected to or dependent on each other.", "Meanwhile, if the UE is configured for PDSCH QCL Behavior B (i.e., QCL between a CSI-RS and a DMRS), the EPDCCH QCL behavior may be configured as either EPDCCH QCL Behavior A ((i.e., QCL between a serving cell CRS and an EPDCCH DMRS) or EPDCCH QCL Behavior B (i.e., QCL between a CSI-RS and an EPDCCH DMRS).", "That is, only when the UE is configured for PDSCH QCL Behavior B, restrictions may be eased such that the EPDCCH QCL behavior may be RRC-configured as EPDCCH QCL Behavior A or B.", "Similarly, if EPDCCH QCL Behavior B is configured, one of PDSCH QCL Behaviors A and B may be configured.", "Alternatively, the aforementioned restrictions may not be applied in order to provide independency of configuration between the PDSCH QCL behavior and the EPDCCH QCL behavior.", "Specifically, if the UE is configured for PDSCH QCL Behavior A (i.e., QCL among a serving cell CRS, a CSI-RS and a DMRS), the EPDCCH QCL Behavior may be configured as either EPDCCH QCL Behavior A (i.e., QCL between a serving cell CRS and an EPDCCH DMRS) or EPDCCH QCL Behavior B (i.e., QCL between a CSI-RS and an EPDCCH DMRS).", "Similarly, if EPDCCH QCL Behavior A is configured, the UE may be configured for one of PDSCH QCL Behaviors A and B.", "Meanwhile, one specific PQI state value to be applied to each EPDCCH set (or to be used for demodulation of a PDSCH scheduled by DCI transmitted through an EPDCCH and/or for decoding of the EPDCCH) may be RRC-configured.", "In this case, if EPDCCH Behavior A (i.e., QCL between a serving cell CRS and an EPDCCH DMRS), the UE may operate according to some of the PQI parameters included in a PQI parameter set linked to the one indicated specific PQI state value and to other PQI parameters of the DL serving cell, in order to perform PDSCH demodulation and/or EPDCCH decoding.", "Herein, the PQI parameters included in a PQI parameter set linked to the one RRC-indicated specific PQI state value may include the number of CRS ports, CRS frequency shift, MBSFN subframe configuration information, NZP CSI-RS configuration information, ZP CSI-RS configuration information, and PDSCH start symbol information.", "For example, the UE may operate according to only the PDSCH start symbol information among the PQI parameters included in a PQI parameter set linked to the one RRC-indicated specific PQI state value and to the other parameters of the serving cell.", "In another example, the UE may operate according to only CRS RM pattern information (e.g., the number of CRS ports of a serving cell, CRS frequency shift of the serving cell, and MBSFN subframe configuration of the serving cell) among the PQI parameters included in a PQI parameter set linked to one RRC-indicated specific PQI state value and to the other parameters of the serving cell.", "In yet another example, the UE may operate according to only ZP CSI-RS configuration information among the PQI parameters included in a PQI parameter set linked to one RRC-indicated specific PQI state value and to the other parameters of the serving cell.", "In yet another example, the UE may operate according to only PDSCH start symbol information and CRS RM pattern information (e.g., the number of CRS ports of a serving cell, CRS frequency shift of the serving cell, and MBSFN subframe configuration of the serving cell) among the PQI parameters included in a PQI parameter set linked to one RRC-indicated specific PQI state value and to the other parameters of the serving cell.", "In yet another example, the UE may operate according to only PDSCH start symbol information and inforaition of one ZP CSI-RS configuration among the PQI parameters included in a PQI parameter set linked to one RRC-indicated specific PQI state value and to the other parameters of the serving cell.", "In yet another example, the UE may operate according to only CRS RM pattern information (e.g., the number of CRS ports of a serving cell, CRS frequency shift of the serving cell, and MBSFN subframe configuration of the serving cell) and information of one ZP CSI-RS configuration among the PQI parameters included in a PQI parameter set linked to one RRC-indicated specific PQI state value and to the other parameters of the serving cell.", "In yet another example, the UE may operate according to only PDSCH start symbol information, CRS RM pattern information (e.g., the number of CRS ports of a serving cell, CRS frequency shift of the serving cell, and MBSFN subframe configuration of the serving cell) and one ZP CSI-RS configuration information among the PQI parameters included in a PQI parameter set linked to one RRC-indicated specific PQI state value and to the other parameters of the serving cell.", "Configuration of PQI Field DCI format 2D for a new transmission mode (e.g., TM10) whose main feature is to support CoMP operation may include a PQI field.", "The PQI field may be defined to have a size of N bits, thereby indicating one of 2̂N state values.", "PQI parameter sets corresponding to the 2̂N PQI state values respectively may be RRC-configured.", "One PQI parameter set may include the number of CRS ports, CRS frequency shift.", "MBSFN subframe configuration information, NZP CSI-RS configuration information, ZP CSI-RS configuration information, and PDSCH start symbol information.", "Accordingly, one of the 2̂N PQI parameter sets may be dynamically indicated or switched according to the PQI state value.", "Meanwhile, DCI format 1A for the fallback operation in TM10 is defined not to include a PQI field.", "In other words, DCI format 1A in TM10 without the PQI field means that a non-CoMP operation is supported by DCI format 1A, and may be interpreted as meaning that only non-CoMP transmission from, for example, a DL serving cell is scheduled.", "In another example, DCI format 1A transmitted in the common search space may be defined not to include the PQI field in order to maintain the same length as that of the other DCI formats.", "On the other hand, DCI format 1A transmitted in the UE-specific search space may be defined to include the PQI field as in the case of DCI format 2D, thereby supporting the CoMP operation.", "In yet another example, DCI format 1A transmitted in a non-MBSFN subframe may be defined not to include a PQI field, while DCI format 1A transmitted in an MBSFN subframe may be defined to include the PQI field as in the case of DCI format 2D.", "Thereby, the CoMP operation may be supported.", "In yet another example, DCI format 1A transmitted in the common search space in a non-MBSFN subframe may be defined not to include the PQI field, while DCI format 1A transmitted in an MBSFN subframe and DCI format 1A transmitted in the UE-specific search space in a non-MBSFN subframe may be defined to include the PQI field as in the case of DCI format 2D.", "Thereby, the CoMP operation may be supported.", "In yet another example, DCI format 1A transmitted in a non-MBSFN subframe and DCI format 1A transmitted in the common search space in an MBSFN subframe may be defined not to include a PQI field, while DCI format 1A transmitted in the UE-specific search space in an MBSFN subframe may be defined to include the PQI field as in the case of DCI format 2D.", "Thereby, the CoMP operation may be supported.", "Meanwhile, the PQI bit width (i.e., N) may be differently defined depending on UE capabilities.", "For example, UE capability for the maximum number (N_P) of CSI processes supported (in TM10) may be defined, and the UE may inform the eNB of the UE capability.", "For example, N_P may be defined as N_P=1, 3, or 4.According to one embodiment of the present invention, it is proposed that the PQI bit width (N) be determined according to the value of N_P (N may be defined to indicate the PQI bit width, the number of PQI states, an encoding pattern of PQI states, or the like).", "If N_P=1, an explicit bit for the PQI may be defined as being not present in a DCI format.", "In this case, although there is no explicit bit for the PQI, a PQI parameter set for one default PQI state may be RRC-signaled as default information, or RRC-configured parameters corresponding to a default PQI state used in DCI format 1A may be defined to be used in DCI format 2D without separate RRC signaling.", "Alternatively, if N_P=1, an explicit bit for the PQI may not be defined, but 2 associated state values (0 or 1) may be used as PQI state values according to the value of the nSCID field.", "Alternatively, if N_P=1, an explicit bit for the PQI may be included in the DCI format.", "Thereby, 2 PQI state values may be provided.", "If N_P=3 or 4, 2 explicit bits for the PQI may be defined to be included in the DCI format.", "Alternatively, if N_P=3 or 4, 1 explicit bit for the PQI may be included in the DCI format, and 2 associated state values (0 and 1) may be combined according to the 1 bit and the value of the nSCID field to indicate one of 3 or 4 PQI states.", "Alternatively, if N_P=3, only one explicit bit for the PQI may be applied, and 2 state values may be restrictively used.", "In the examples described above, PQI bit width (or the number of PQI states) N is statically determined according to the UE capability value N_P for the maximum number of supported CSI processes.", "Similarly, the maximum value of the PQI bit width (or the number of PQI states) may be determined according to the value of N_P.", "That is, a PQI parameter set may be RRC-configured within the maximum value of the PQI bit width.", "Meanwhile, RRC parameter set information of a PQI state to be used in DCI format 1A may be statically used for a specific PQI state (e.g., the lowest state index) of DCI format 2D.", "In addition, as a PQI parameter to be used in the case of DCI format 1A, a PQI parameter indicated by a specific PQI state of DCI format 2D may be RRC-configured.", "FIG.", "12 is a flowchart illustrating a method for transmitting and receiving a PDSCH signal according to one embodiment of the present invention.", "In step S1210, the UE may be assigned a PDSCH according to DCI format 1A by an eNB.", "If the UE is set to TM10, the PDSCH allocated according to DCI format 1A corresponds to a PDSCH scheduled in the fallback mode.", "In the example of FIG.", "12, it is assumed that the UE receives a PDSCH n a non-MBSFN subframe.", "In step S1220, the UE may determine whether DCI format 1A for allocating the PDSCH has been received through an EPDCCH.", "If it is determined that the DCI format 1A has been received through the EPDCCH as a result of step S1220, the process may proceed to step S1230.In step S1230, the UE may determine the PDSCH start symbol index according to an EPDSCH start symbol value.", "Herein, the EPDSCH start symbol value may be set for each EPDCCH set by a higher layer.", "The UE may determine the PDSCH start symbol index according to the EPDSCH start symbol value allocated to an EPDCCH set in which the EPDCCH has been detected.", "As a result of step S1220, if DCI format 1A has not been received through the EPDCCH (i.e., if DCI format 1A has been received through, for example, a PDCCH), step 1240 is performed, operation may proceed to step S1240.In step S1230, the UE may determine a PDSCH start symbol based on the CFI value.", "In the example of the present invention described above with reference to FIG.", "12, if a PDSCH is received in a non-MBSFN subframe, the PDSCH and a PDCCH/EPDCCH through which DCI format 1A for allocating the PDSCH may be transmitted form the same serving cell.", "As described above, for a PDSCH allocated according to DCI format 1A, the UE may determine a PDSCH start symbol according to the type of a control channel (e.g., EPDCCH) through which DCI format 1A is received, thereby receiving a PDSCH signal.", "Regarding the PDSCH signal transmission and reception method described above with reference to FIG.", "12, details of the various embodiments of the present invention described above may be independently applied or two or more embodiments may be simultaneously applied.", "Redundant description is omitted.", "FIG.", "13 is a diagram illustrating configurations of a UE and an eNB according to one embodiment of the present invention.", "Referring to FIG.", "13, an eNB 10 may include a receive module 11, a transmit module 12, a processor 13, a memory 14, and a plurality of antennas 15.The receive module 11 may receive various signals, data and information from external devices (e.g., a UE).", "The transmit module 12 may transmit various signals, data and information to external devices (e.g., a UE).", "The processor 12 may control overall operation of the eNB 10.The antennas 15 suggest that the eNB 10 supports MIMO transmission and reception.", "According to one embodiment of the present invention, the eNB 10 may be configured to transmit a PDSCH signal to the UE 20.The processor 13 may control the transmit module 12 to signal information about PDSCH allocation to the UE 20 through DCI format 1A.", "If the subframe in which the PDSCH is transmitted is a non-MBSFN subframe, and DCI format 1A is transmitted through an EPDCCH, the processor 13 may determine the PDSCH start symbol index according to the EPDSCH start symbol value configured for the UE through higher layer signaling.", "Then, the processor 13 may map the PDSCH signal to a downlink subframe and transmit the same to the UE 20 via the transmit module 12.If the subframe in which the PDSCH is transmitted is a non-MBSFN subframe, and DCI format 1A is transmitted through an EPDCCH, the processor 13 may determine the PDSCH start symbol index according to the CFI value provided to the UE 20 through the PCFICH.", "Then, the processor 13 may map the PDSCH signal to a downlink subframe and transmit the same to the UE 20 via the transmit module 12.Additionally, the processor 12 of the eNB 10 may function to operationally process information received by the eNB 10 or information to be transmitted from the eNB 10, and the memory 14, which may be replaced with an element such as a buffer (not shown), may store the processed information for a predetermined time.", "Referring to FIG.", "13, a UE 20 may include a receive module 21, a transmit module 22, a processor 23, a memory 24, and a plurality of antennas 25.The receive module 21 may receive various signals, data and information from external devices (e.g., an eNB).", "The transmit module 22 may transmit various signals, data and information to external devices (e.g., an eNB).", "The processor 23 may control overall operation of the UE 20.That there are plural antennas 25 suggests that the UE 20 supports MIMO transmission and reception.", "According to one embodiment of the present invention, the UE 20 may be configured to receive a PDSCH signal from the eNB 10.The processor 23 may be configured to determine the start symbol index of the PDSCH in a downlink subframe.", "The processor 23 may be configured to receive a PDSCH signal based on the PDSCH start symbol index, using the receive module 21.The processor 23 may receive PDSCH allocation information through downlink control information (DCI).", "If the DCI is configured according to DCI format 1A transmitted through the EPDCCH and the downlink subframe is a non-MBSFN subframe, the processor 23 may determine the start symbol index according to the EPDCCH start symbol value configured by a higher layer.", "If the DCI is configured according to DCI format 1A transmitted through the PDSCH and the downlink subframe is a non-MBSFN subframe, the processor 23 may determine the start symbol index according to the CFI value.", "Additionally, the processor 23 of the UE 20 may function to operationally process information received by the UE 20 or information to be transmitted from the UE 20, and the memory 24, which may be replaced with an element such as a buffer (not shown), may store the processed information for a predetermined time.", "The configurations of the eNB 10 and the UE 20 as described above may be implemented such that details of the various embodiments described above are independently applied or two or more embodiments are simultaneously applied.", "Redundant description is omitted.", "In describing the various embodiments of the present invention above, the eNB has been exemplarily described as serving as a downlink transmit entity or an uplink receive entity, and the UE has been exemplarily described as serving as a downlink receive entity or an uplink transmit entity.", "However, embodiments of the present invention are not limited thereto.", "For example, the description of the eNB given above may be equally applied to a case in which a cell, an antenna port, an antenna port group, an RRH, a transmission point, a reception point, an access point, and a relay serve as a downlink transmit entity or an uplink receive entity with respect to the UE.", "In addition, the principle of the present invention described above through various embodiments may be equally applied to a case in which a relay serves as a a downlink transmit entity or an uplink receive entity with respect to the UE or to a case in which the relay serves as an uplink transmit entity or a downlink receive entity with respect to the eNB.", "The embodiments of the present invention may be implemented through various means, for example, hardware, firmware, software, or a combination thereof.", "When implemented as hardware, a method according to embodiments of the present invention may be embodied as one or more application specific integrated circuits (ASICs), one or more digital signal processors (DSPs), one or more digital signal processing devices (DSPDs), one or more programmable logic devices (PLDs), one or more field programmable gate arrays (FPGAs), a processor, a controller, a microcontroller, a microprocessor, etc.", "When implemented as firmware or software, a method according to embodiments of the present invention may be embodied as a module, a procedure, or a function that performs the functions or operations described above.", "Software code may be stored in a memory unit and executed by a processor.", "The memory unit is located at the interior or exterior of the processor and may transmit and receive data to and from the processor via various known means.", "Preferred embodiments of the present invention have been described in detail above to allow those skilled in the art to implement and practice the present invention.", "Although the preferred embodiments of the present invention have been described above, those skilled in the art will appreciate that various modifications and variations can be made in the present invention without departing from the spirit or scope of the invention.", "For example, those skilled in the art may use a combination of elements set forth in the above-described embodiments.", "Thus, the present invention is not intended to be limited to the embodiments described herein, but is intended to have the widest scope corresponding to the principles and novel features disclosed herein.", "The present invention may be carried out in other specific ways than those set forth herein without departing from the essential characteristics of the present invention.", "Therefore, the above embodiments should be construed in all aspects as illustrative and not restrictive.", "The scope of the invention should be determined by the appended claims and their legal equivalents, and all changes coming within the meaning and equivalency range of the appended claims are intended to be embraced therein.", "The present invention is not intended to be limited to the embodiments described herein, but is intended to have the widest scope consistent with the principles and novel features disclosed herein.", "In addition, claims that are not explicitly cited in each other in the appended claims may be presented in combination as an embodiment of the present invention or included as a new claim by subsequent amendment after the application is filed.", "INDUSTRIAL APPLICABILITY The embodiments of the present invention described above are applicable to various mobile communication systems." ] ]
Patent_15872819
[ [ "METHODS OF MAKING WIRING SUBSTRATE FOR STACKABLE SEMICONDUCTOR ASSEMBLY AND MAKING STACKABLE SEMICONDUCTOR ASSEMBLY", "The wiring substrate includes a cavity and a plurality of metal leads disposed around the cavity.", "The metal leads are bonded with a resin compound and provide horizontal and vertical routing for a semiconductor device to be disposed in the cavity.", "The resin compound fills in spaces between the metal leads and surrounds the cavity and provides a dielectric platform for a re-distribution layer or a build-up circuitry optionally deposited thereon." ], [ "1.A method of making a wiring substrate, the method comprising steps of: providing a metal frame, a metal slug and a plurality of metal leads, wherein the metal slug is located within the metal frame, and the metal leads are integrally connected to the metal frame and each has an inner end directed inwardly away from the metal frame and directed toward the metal slug; providing a resin compound that fills in remaining spaces within the metal frame, wherein the resin compound has a top surface substantially coplanar with top sides of the metal leads and the metal slug; and removing at least one selected portion of the metal slug to form a cavity, wherein the cavity has an entrance at the top surface of the resin compound.", "2.The method of claim 1, further comprising a step of separating the metal frame from the metal leads.", "3.The method of claim 2, wherein the step of separating the metal frame includes chemical etching or mechanical trimming or cutting.", "4.The method of claim 1, wherein the step of removing at least one selected portion of the metal slug includes leaving a remaining portion of the metal slug as a metal paddle located adjacent to a bottom of the cavity.", "5.The method of claim 4, wherein the metal paddle has a bottom surface substantially coplanar with those of the resin compound and the metal leads.", "6.The method of claim 4, wherein the step of removing at least one selected portion of the metal slug further includes leaving an additional remaining portion of the metal slug on an interior sidewall surface of the resin compound.", "7.The method of claim 1, further comprising a step of forming a top re-distribution layer on the top surface of the resin compound and electrically coupled to the metal leads.", "8.The method of claim 7, further comprising a step of disposing an electronic component within the metal frame before the step of providing the resin compound, wherein the top re-distribution layer further electrically couples the electronic component to at least one of the metal leads.", "9.The method of claim 1, further comprising a step of forming a bottom build-up circuitry on a bottom surface of the resin compound and electrically coupled to the metal leads.", "10.The method of claim 9, wherein the step of removing at least one selected portion of the metal slug includes leaving a remaining portion of the metal slug as a metal paddle located adjacent to a bottom of the cavity, and the bottom build-up circuitry is electrically to and thermally conductible to the metal paddle.", "11.The method of claim 1, wherein the metal slug is thinner than the metal leads, and the step of providing the resin compound includes providing a resin paddle on a bottom side of the metal slug, the resin paddle being integral with the resin compound.", "12.A method of making a stackable semiconductor assembly, the method comprising steps of: providing a wiring substrate by the method of claim 1; and disposing a semiconductor device in the cavity of the wiring substrate and electrically coupling the semiconductor device to the wiring substrate through bonding wires.", "13.The method of claim 12, wherein the step of removing at least one selected portion of the metal slug includes leaving a remaining portion of the metal slug as a metal paddle located adjacent to a bottom of the cavity and leaving an additional remaining portion of the metal slug on an interior sidewall surface of the resin compound, and the step of electrically coupling the semiconductor device to the wiring substrate includes electrically coupling the semiconductor device to the additional remaining portion of the metal slug through at least one of the bonding wires.", "14.The method of claim 12, wherein (i) the semiconductor device includes a routing circuitry, a first chip and a second chip, (ii) the first chip is electrically coupled to a top surface of the routing circuitry, (iii) the second chip is electrically coupled to a bottom surface of the routing circuitry, and (iv) the bonding wires electrically couple the routing circuitry to the wiring substrate." ], [ "<SOH> FIELD OF THE INVENTION <EOH>The present invention relates to methods of making a wiring substrate and making a semiconductor assembly and, more particularly, to a method of making a wiring substrate having a cavity surrounded by an array of metal leads for vertical interconnection channel, and a method of making a stackable semiconductor assembly using the wiring substrate." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>An objective of the present invention is to provide a method of making a wiring substrate having a cavity by etching of a sacrificial metal slug at a designated location.", "As this sacrificial metal slug is mechanically supported and physically surrounded by a resin compound, once a selected portion of metal is removed, a cavity with well-defined size and depth can be formed and surrounded by the resin compound, thereby allowing a device to be disposed in the cavity without contributing much thickness to the final assembly.", "Another objective of the present invention is to provide a method of making a wiring substrate having vertical stacking channel by providing a plurality of metal leads surrounding a cavity.", "As a result, a device disposed in the cavity can be stacked with another device through the metal leads without the need for other external interconnection.", "Yet another objective of the present invention is to provide a method of making a wiring substrate with all the elements bonded together by a resin compound, thereby allowing a stable mechanical structure that can endure thermal cycling without suffering solder cracking, warping or dislocation.", "Yet another objective of the present invention is to provide a method of making a wiring substrate optionally having a routing circuitry so that the electrical signal can be re-distributed from the peripheral leads to the designated location and the electrical characteristics of the resulting semiconductor assembly can be greatly improved.", "In accordance with the foregoing and other objectives, the present invention provides a method of making a wiring substrate, comprising: providing a metal frame, a metal slug and a plurality of metal leads, wherein the metal slug is located within the metal frame, and the metal leads are integrally connected to the metal frame and each has an inner end directed inwardly away from the metal frame and directed toward the metal slug; providing a resin compound that fills in remaining spaces within the metal frame, wherein the resin compound has a top surface substantially coplanar with top sides of the metal leads and the metal slug; and removing at least one selected portion of the metal slug to form a cavity, wherein the cavity has an entrance at the top surface of the resin compound.", "Optionally, the method of making the wiring substrate may further comprise step(s) of: forming a top re-distribution layer on the top surface of the resin compound and electrically coupled to the metal leads; and/ or forming a bottom build-up circuitry on a bottom surface of the resin compound and electrically coupled to the metal leads.", "Additionally, the present invention also provides a method of making a stackable semiconductor assembly, comprising steps of: providing the aforementioned wiring substrate by the above-mentioned method, and disposing a semiconductor device in the cavity of the wiring substrate and electrically coupling the semiconductor device to the wiring substrate through bonding wires.", "Unless specifically indicated or using the term “then” between steps, or steps necessarily occurring in a certain order, the sequence of the above-mentioned steps is not limited to that set forth above and may be changed or reordered according to desired design.", "The methods of making a wiring substrate and making the related 3D stackable semiconductor assembly using the wiring substrate according to the present invention have numerous advantages.", "For instance, providing the metal leads around the cavity is particularly advantageous as the semiconductor device can be disposed in the cavity and the metal leads can be electrically connected to the semiconductor device by the bonding wires and offer horizontal routing and vertical connecting channels between two opposites side of the wiring substrate.", "As the semiconductor device is disposed in the cavity, no extra grinding or lapping is needed for the semiconductor device in order to achieve ultra-thin vertically stacked semiconductor assembly feature.", "Binding the resin compound to the metal leads can provide a integral platform for high resolution circuitries disposed thereon.", "Depositing the re-distribution layer on the resin compound can enhance routing flexibility of the wiring substrate and allow fine pitch assemblies such as flip chip and surface mount component to be assembled thereon and interconnected to the metal leads by the re-distribution layer.", "These and other features and advantages of the present invention will be further described and more readily apparent from the detailed description of the preferred embodiments which follows." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation-in-part of U.S. application Ser.", "No.", "15/642,253 filed Jul.", "5, 2017, a continuation-in-part of U.S. application Ser.", "No.", "15/642,256 filed Jul.", "5, 2017, a continuation-in-part of U.S. application Ser.", "No.", "15/787,366 filed Oct. 18, 2017 and a continuation-in-part of U.S. application Ser.", "No.", "15/863,998 filed Jan. 8, 2018.The U.S. application Ser.", "No.", "15/642,253 is a continuation-in-part of U.S. application Ser.", "No.", "14/621,332 filed Feb. 12, 2015 and a continuation-in-part of U.S. application Ser.", "No.", "14/846,987 filed Sep. 7, 2015.The U.S. application Ser.", "No.", "15/787,366 is a continuation-in-part of U.S. application Ser.", "No.", "15/247,443 filed Aug. 25, 2016.The U.S. application Ser.", "No.", "15/863,998 is a continuation-in-part of U.S. application Ser.", "No.", "14/621,332 filed Feb. 12, 2015, a continuation-in-part of U.S. application Ser.", "No.", "14/846,987 filed Sep. 7, 2015, a continuation-in-part of U.S. application Ser.", "No.", "15/642,253 filed Jul.", "5, 2017 and a continuation-in-part of U.S. application Ser.", "No.", "15/642,256 filed Jul.", "5, 2017.The U.S. application Ser.", "No.", "14/621,332 claims the benefit of filing date of U.S.", "Provisional Application Ser.", "No.", "61/949,652 filed Mar.", "7, 2014.The U.S. application Ser.", "No.", "14/846,987 is a continuation-in-part of U.S. application Ser.", "No.", "14/621,332 filed Feb. 12, 2015.The U.S. application Ser.", "No.", "15/247,443 claims the benefit of filing date of U.S.", "Provisional Application Ser.", "No.", "62/214,187 filed Sep. 3, 2015.The entirety of each of said Applications is incorporated herein by reference.", "FIELD OF THE INVENTION The present invention relates to methods of making a wiring substrate and making a semiconductor assembly and, more particularly, to a method of making a wiring substrate having a cavity surrounded by an array of metal leads for vertical interconnection channel, and a method of making a stackable semiconductor assembly using the wiring substrate.", "DESCRIPTION OF RELATED ART Market trends of multimedia devices demand for faster and slimmer designs.", "One of the approaches is to assemble multiple devices on a wiring substrate with stacking configuration so that the electrical performance can be improved and the form-factor can be further minimized.", "U.S. Pat.", "No.", "7,894,203 discloses a wiring substrate having a cavity for such kind of purpose.", "The disclosed substrate is made of two separated parts bonded together by an adhesive.", "The electrical connection between them is through a conductive material such as solder or conductive bump.", "As the substrate is a stacked structure, warpage or thermal expansion coefficient (CTE) mismatches between these two parts will result in dislocation or solder cracking, making this kind of stacking structure unreliable for practical usage.", "Alternatively, as described in U.S. Pat.", "No.", "7,989,950, vertical connection channel is formed by attaching a solder ball on a substrate and sealed by encapsulation and thus form a cavity.", "Again, solder deforming and cracking in the encapsulation, or delamination between the encapsulant and the substrate after thermal cycling may lead to abrupt device failure and I/O disconnection.", "For the reasons stated above, and for other reasons stated below, developing a wiring substrate having integral metal leads extending to the top and bottom of the wiring substrate for 3D stacking of semiconductor assembly would be highly desirable.", "SUMMARY OF THE INVENTION An objective of the present invention is to provide a method of making a wiring substrate having a cavity by etching of a sacrificial metal slug at a designated location.", "As this sacrificial metal slug is mechanically supported and physically surrounded by a resin compound, once a selected portion of metal is removed, a cavity with well-defined size and depth can be formed and surrounded by the resin compound, thereby allowing a device to be disposed in the cavity without contributing much thickness to the final assembly.", "Another objective of the present invention is to provide a method of making a wiring substrate having vertical stacking channel by providing a plurality of metal leads surrounding a cavity.", "As a result, a device disposed in the cavity can be stacked with another device through the metal leads without the need for other external interconnection.", "Yet another objective of the present invention is to provide a method of making a wiring substrate with all the elements bonded together by a resin compound, thereby allowing a stable mechanical structure that can endure thermal cycling without suffering solder cracking, warping or dislocation.", "Yet another objective of the present invention is to provide a method of making a wiring substrate optionally having a routing circuitry so that the electrical signal can be re-distributed from the peripheral leads to the designated location and the electrical characteristics of the resulting semiconductor assembly can be greatly improved.", "In accordance with the foregoing and other objectives, the present invention provides a method of making a wiring substrate, comprising: providing a metal frame, a metal slug and a plurality of metal leads, wherein the metal slug is located within the metal frame, and the metal leads are integrally connected to the metal frame and each has an inner end directed inwardly away from the metal frame and directed toward the metal slug; providing a resin compound that fills in remaining spaces within the metal frame, wherein the resin compound has a top surface substantially coplanar with top sides of the metal leads and the metal slug; and removing at least one selected portion of the metal slug to form a cavity, wherein the cavity has an entrance at the top surface of the resin compound.", "Optionally, the method of making the wiring substrate may further comprise step(s) of: forming a top re-distribution layer on the top surface of the resin compound and electrically coupled to the metal leads; and/ or forming a bottom build-up circuitry on a bottom surface of the resin compound and electrically coupled to the metal leads.", "Additionally, the present invention also provides a method of making a stackable semiconductor assembly, comprising steps of: providing the aforementioned wiring substrate by the above-mentioned method, and disposing a semiconductor device in the cavity of the wiring substrate and electrically coupling the semiconductor device to the wiring substrate through bonding wires.", "Unless specifically indicated or using the term “then” between steps, or steps necessarily occurring in a certain order, the sequence of the above-mentioned steps is not limited to that set forth above and may be changed or reordered according to desired design.", "The methods of making a wiring substrate and making the related 3D stackable semiconductor assembly using the wiring substrate according to the present invention have numerous advantages.", "For instance, providing the metal leads around the cavity is particularly advantageous as the semiconductor device can be disposed in the cavity and the metal leads can be electrically connected to the semiconductor device by the bonding wires and offer horizontal routing and vertical connecting channels between two opposites side of the wiring substrate.", "As the semiconductor device is disposed in the cavity, no extra grinding or lapping is needed for the semiconductor device in order to achieve ultra-thin vertically stacked semiconductor assembly feature.", "Binding the resin compound to the metal leads can provide a integral platform for high resolution circuitries disposed thereon.", "Depositing the re-distribution layer on the resin compound can enhance routing flexibility of the wiring substrate and allow fine pitch assemblies such as flip chip and surface mount component to be assembled thereon and interconnected to the metal leads by the re-distribution layer.", "These and other features and advantages of the present invention will be further described and more readily apparent from the detailed description of the preferred embodiments which follows.", "BRIEF DESCRIPTION OF THE DRAWINGS The following detailed description of the preferred embodiments of the present invention can best be understood when read in conjunction with the following drawings, in which: FIGS.", "1, 2 and 3 are cross-sectional, top perspective and bottom perspective views, respectively, of a textured metal sheet in accordance with the first embodiment of the present invention; FIGS.", "4, 5 and 6 are cross-sectional, top perspective and bottom perspective views, respectively, of the structure of FIGS.", "1, 2 and 3 further provided with a resin compound in accordance with the first embodiment of the present invention; FIGS.", "7, 8 and 9 are cross-sectional, top perspective and bottom perspective views, respectively, of the structure after selective etching of the textured metal sheet of FIGS.", "4, 5 and 6 to finish the fabrication of an untrimmed wiring substrate in accordance with the first embodiment of the present invention; FIGS.", "10 and 11 are cross-sectional and top perspective views, respectively, of the structure of FIGS.", "7 and 8 further provided with a semiconductor device and bonding wires in accordance with the first embodiment of the present invention; FIGS.", "12 and 13 are cross-sectional and top perspective views, respectively, of the structure of FIGS.", "10 and 11 further provided with a molding compound in accordance with the first embodiment of the present invention; FIGS.", "14, 15 and 16 are cross-sectional, top perspective and bottom perspective views, respectively, of a semiconductor assembly trimmed from the structure of FIGS.", "12 and 13 in accordance with the first embodiment of the present invention; FIGS.", "17 and 18 are cross-sectional and top perspective views, respectively, of a three-dimensional stacked semiconductor package having two semiconductor assemblies of FIG.", "14 in accordance with the first embodiment of the present invention; FIG.", "19 is a cross-sectional view of another semiconductor assembly having another aspect of the semiconductor device electrically coupled to the untrimmed wiring substrate of FIG.", "7 in accordance with the first embodiment of the present invention; FIGS.", "20 and 21 are cross-sectional and top perspective views, respectively, of another aspect of the untrimmed wiring substrate in accordance with the first embodiment of the present invention; FIGS.", "22 and 23 are cross-sectional and top perspective views, respectively, of the structure of FIGS.", "20 and 21 further provided with a semiconductor device and bonding wires in accordance with the first embodiment of the present invention; FIGS.", "24 and 25 are cross-sectional and top perspective views, respectively, of the structure of FIGS.", "22 and 23 further provided with a molding compound in accordance with the first embodiment of the present invention; FIGS.", "26, 27 and 28 are cross-sectional, top perspective and bottom perspective views, respectively, of a semiconductor assembly trimmed from the structure of FIGS.", "24 and 25 in accordance with the first embodiment of the present invention; FIGS.", "29 and 30 are cross-sectional and top perspective views, respectively, of a three-dimensional stacked semiconductor package having two semiconductor assemblies of FIG.", "26 in accordance with the first embodiment of the present invention; FIG.", "31 is a cross-sectional view of another semiconductor assembly having another aspect of the semiconductor device electrically coupled to the untrimmed wiring substrate of FIG.", "20 in accordance with the first embodiment of the present invention; FIGS.", "32 and 33 are cross-sectional and top perspective views, respectively, of another aspect of the wiring substrate having a re-distribution layer deposited directly on the resin compound in accordance with the first embodiment of the present invention; FIGS.", "34 and 35 are cross-sectional and top perspective views, respectively, of the structure of FIGS.", "32 and 33 further provided with a semiconductor device, a passive component, bonding wires and a molding compound in accordance with the first embodiment of the present invention; FIG.", "36 is a cross-sectional view of a three-dimensional stacked semiconductor package having two semiconductor assemblies of FIG.", "34 in accordance with the first embodiment of the present invention; FIG.", "37 is a cross-sectional view of yet another aspect of the untrimmed wiring substrate having an electronic compound embedded in the resin compound in accordance with the first embodiment of the present invention; FIGS.", "38 and 39 are cross-sectional and bottom perspective views, respectively, of the structure having a textured metal sheet bonded with a resin compound in accordance with the two embodiment of the present invention; FIGS.", "40 and 41 are cross-sectional and bottom perspective views, respectively, of the structure of FIGS.", "38 and 39 further provided with a dielectric layer, first via openings and second via openings in accordance with the two embodiment of the present invention; FIGS.", "42 and 43 are cross-sectional and bottom perspective views, respectively, of the structure of FIGS.", "40 and 41 further provided with a bottom patterned metal layer in accordance with the two embodiment of the present invention; FIGS.", "44 and 45 are cross-sectional and top perspective views, respectively, of the structure after selective etching of the textured metal sheet of FIGS.", "42 and 43 to finish the fabrication of a wiring substrate in accordance with the second embodiment of the present invention; FIGS.", "46 and 47 are cross-sectional and top perspective views, respectively, of the structure of FIGS.", "44 and 45 further provided with a semiconductor device, bonding wires and a molding compound in accordance with the second embodiment of the present invention; FIG.", "48 is a cross-sectional view of a three-dimensional stacked semiconductor package having the semiconductor assembly of FIG.", "14 stacked on the semiconductor assembly of FIG.", "46 in accordance with the second embodiment of the present invention; FIG.", "49 is a cross-sectional view of another semiconductor assembly having another aspect of the semiconductor device electrically coupled to the wiring substrate of FIG.", "44 in accordance with the second embodiment of the present invention; FIG.", "50 is a cross-sectional view of a textured metal sheet in accordance with the third embodiment of the present invention; FIGS.", "51 and 52 are cross-sectional and bottom perspective views, respectively, of the structure of FIG.", "50 further provided with a resin compound in accordance with the third embodiment of the present invention; FIGS.", "53 and 54 are cross-sectional and top perspective views, respectively, of the structure after selective etching of the textured metal sheet of FIGS.", "51 and 52 to finish the fabrication of an untrimmed wiring substrate in accordance with the third embodiment of the present invention; FIGS.", "55 and 56 are cross-sectional and top perspective views, respectively, of the structure of FIGS.", "53 and 54 further provided with a semiconductor device and bonding wires in accordance with the third embodiment of the present invention; FIGS.", "57 and 58 are cross-sectional and top perspective views, respectively, of the structure of FIGS.", "55 and 56 further provided with a molding compound in accordance with the third embodiment of the present invention; FIGS.", "59, 60 and 61 are cross-sectional, top perspective and bottom perspective views, respectively, of a semiconductor assembly trimmed from the structure of FIGS.", "57 and 58 in accordance with the third embodiment of the present invention; FIGS.", "62 and 63 are cross-sectional and top perspective views, respectively, of a three-dimensional stacked semiconductor package having two semiconductor assemblies of FIG.", "59 in accordance with the third embodiment of the present invention; FIG.", "64 is a cross-sectional view of another semiconductor assembly having another aspect of the semiconductor device electrically coupled to the untrimmed wiring substrate of FIG.", "53 in accordance with the third embodiment of the present invention; FIG.", "65 is a cross-sectional view of another aspect of the wiring substrate in accordance with the third embodiment of the present invention; FIG.", "66 is a cross-sectional view of yet another aspect of the wiring substrate in accordance with the third embodiment of the present invention; FIG.", "67 is a cross-sectional view of yet another aspect of the wiring substrate in accordance with the third embodiment of the present invention; and FIG.", "68 is a cross-sectional view of the structure of FIG.", "67 further provided with a semiconductor device, a passive component, bonding wires and a molding compound in accordance with the third embodiment of the present invention.", "DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereafter, examples will be provided to illustrate the embodiments of the present invention.", "Advantages and effects of the invention will become more apparent from the following description of the present invention.", "It should be noted that these accompanying figures are simplified and illustrative.", "The quantity, shape and size of components shown in the figures may be modified according to practical conditions, and the arrangement of components may be more complex.", "Other various aspects also may be practiced or applied in the invention, and various modifications and variations can be made without departing from the spirit of the invention based on various concepts and applications.", "Embodiment 1 FIGS.", "1-16 are schematic views showing a method of making a semiconductor assembly that includes a plurality of metal leads, a metal paddle, a metal film, a resin compound, a semiconductor device, a plurality of bonding wires and a molding compound in accordance with the first embodiment of the present invention.", "FIGS.", "1, 2 and 3 are cross-sectional, top and bottom perspective views, respectively, of a textured metal sheet 10.The textured metal sheet 10 typically is made of copper alloys, steel or alloy 42, and can be formed by a wet etching or stamping/punching process from a rolled metal strip having a thickness in a range from about 0.15 mm to about 1.0 mm.", "The etching process may be a one-sided or two-sided etching to etch through the metal strip and thereby transfer the metal strip into a desired overall pattern of the textured metal sheet 10 that includes a metal frame 11, a plurality of metal leads 13, a metal slug 15 and a plurality of tie bars 16.The metal leads 13 laterally extend from the metal frame 11 toward the central area within the metal frame 11.As a result, the metal leads 13 each have an outer end 131 integrally connected to interior sidewalls of the metal frame 11 and an inner end 133 directed inwardly away from the metal frame 11.The metal slug 15 is located at the central area within the metal frame 11 and connected to the metal frame 11 by the tie bars 16.Additionally, in this embodiment, the textured metal sheet 10 is further selectively half-etched from its bottom side.", "Accordingly, the metal leads 13 have stepped peripheral edges.", "The metal leads 13 each have a horizontally elongated portion 136 and a vertically projected portion 137.The vertically projected portion 137 protrudes from a lower surface of the horizontally elongated portion 136 in the downward direction.", "FIGS.", "4, 5 and 6 are cross-sectional, top and bottom perspective views, respectively, of the structure provided with a resin compound 30.The resin compound 30 can be deposited by applying a resin material into the remaining spaces within the metal frame 11.The resin material can be applied by paste printing, compressive molding, transfer molding, liquid injection molding, spin coating, or other suitable methods.", "Then, a thermal process (or heat-hardened process) is applied to harden the resin material and to transform it into a solid molding compound.", "As a result, the resin compound 30 covers the lower surfaces of the horizontally elongated portions 136 as well as sidewalls of the vertically projected portions 137 and sidewalls of the metal slug 15.By the stepped cross-section profile of the metal leads 13, the resin compound 30 can securely interlock with the metal leads 13 so as to prevent the metal leads 13 from being vertically forced apart from the resin compound 30 and also to avoid micro-cracking at the interface along the vertical direction.", "In this illustration, the top surface 301 of the resin compound 30 is substantially coplanar with the top sides 101 of the metal leads 13 and the metal slug 15, whereas the bottom surface 303 of the resin compound 30 is substantially coplanar with the bottom sides 103 of the metal leads 13 and the metal slug 15 by planarization.", "The resin compound 30 typically includes binder resins, fillers, hardeners, diluents, and additives.", "There is no particular limit to the binder resin that can be used in accordance with the present invention.", "For example, the binder resin may be at least one selected from the group consisting of an epoxy resin, a phenol resin, a polyimide resin, a polyurethane resin, a silicone resin, a polyester resin, an acrylate, bismaleimide (BMI), and equivalents thereof.", "The binder resin provides intimate adhesion between an adherent and the filler.", "The binder resin also serves to elicit thermal conductivity through chain-like connection of the filler.", "The binder resin may also improve physical and chemical stability of the molding compound.", "Additionally, there is no particular limit to the filler that can be used in accordance with the present invention.", "For example, a thermally conductive filler may be selected from the group consisting of aluminum oxide, aluminum nitride, silicon carbide, tungsten carbide, boron carbide, silica and equivalents thereof.", "More specifically, the resin compound 30 may become thermally conductive or have low CTE if suitable fillers are dispersed therein.", "For example, aluminum nitride (AlN) or silicon carbide (SiC) has relatively high thermal conductivity, high electrical resistance, and a relatively low coefficient of thermal expansion (CTE).", "Accordingly, when the resin compound 30 employs these kinds of materials as fillers, the resin compound 30 would exhibit improved heat dissipation performance, electrical isolation performance and show inhibition of delamination or cracking of circuitry or interfaces due to low CTE.", "The maximum particle size of the thermally conductive filler may be 25 μm or less.", "The content of the filler may be in the range of 10 to 90% by weight.", "If the content of the thermally conductive filler is less than 10% by weight, this may result in insufficient thermal conductivity and excessively low viscosity.", "Low viscosity means that it may be difficult to handle and control the process due to excessively easy outflow of the resin from the tool during dispensing or molding process.", "On the other hand, if the content of the filler is higher than 90% by weight, this may result in decreased adhesive strength and excessively high viscosity of the molding material.", "High viscosity of the molding material results in poor workability due to no outflow of the material from the tool during the dispensing or molding process.", "Additionally, the resin compound 30 may include more than one type of fillers.", "For example, the second filler may be polytetrafluoroethylene (PTFE) so as to further improve electrical isolation property of the resin compound 30.In any case, the resin compound 30 preferably has an elastic modulus larger than 1.0 GPa and a linear coefficient of thermal expansion in a range from about 5×10−6K−1 to about 15×10−6 K−1.FIGS.", "7, 8 and 9 are cross-sectional, top and bottom perspective views, respectively, of the structure after selective removal of the metal slug 15.The metal slug 15 can be selectively removed by numerous techniques, such as wet chemical etching, electro-chemical etching or laser, to form a cavity 305 that has an entrance at the top surface 301 of the resin compound 30.The remaining portion of the metal slug 15 consists of a metal paddle 156 and a metal film 158.The metal paddle 156 has a top surface 152 as a bottom of the cavity 305 and a bottom surface 153 substantially coplanar with the bottom surface 303 of the resin compound 30 and the bottom sides 101 of the metal leads 13.The metal film 158 is disposed on an interior sidewall surface of the resin compound 30 and integral with the metal paddle 156 and laterally surrounds the cavity 305.At this stage, an untrimmed wiring substrate 100 is accomplished and includes the metal frame 11, the metal leads 13, the metal paddle 156, the metal film 158, the tie bars 16 and the resin compound 30.FIGS.", "10 and 11 are cross-sectional and top perspective views, respectively, of the structure with a semiconductor device 61 electrically coupled to the wiring substrate 100.The semiconductor device 61, illustrated as a chip, is face-up disposed in the cavity 305 and attached on the metal paddle 156 and electrically coupled to the metal leads 13 and the metal film 158 through bonding wires 71.As a result, the semiconductor device 61 can be thermally conductible to the metal paddle 156 and electrically coupled to the metal leads 13 for signal routing and to the metal film 158 for ground connection through the bonding wires 71 electrically connecting the semiconductor device 61 to the metal leads 13 and the metal film 158 typically by gold or copper ball bonding, or gold or aluminum wedge bonding.", "FIGS.", "12 and 13 are cross-sectional and top perspective views, respectively, of the structure provided with a molding compound 81.Optionally, the molding compound 81 may be further provided to cover and encapsulate the semiconductor device 61 and the bonding wires 71 from above, and further extends into gaps between the semiconductor device 61 and interior sidewalls of the cavity 305.FIGS.", "14, 15 and 16 are cross-sectional, top and bottom perspective views, respectively, of a semiconductor assembly 110 after removal of the metal frame 11.Removal of the metal frame 11 can be done by various methods including chemical etching, mechanical trimming/cutting or sawing to separate the metal frame 11 from the outer ends 131 of the metal leads 13.As a result, the outer ends 131 of the metal leads 13 are situated at peripheral edges of the trimmed wiring substrate 100 and have a lateral surface flush with peripheral edges of the resin compound 30.FIGS.", "17 and 18 are cross-sectional and top perspective views, respectively, of a three-dimensional stacked semiconductor package having two semiconductor assemblies 110 of FIG.", "14 electrically connected to each other by solder balls 85.The upper semiconductor assembly 110 is stacked on and electrically coupled to the lower semiconductor assembly 110 by solder balls 85 in contact with the vertically projected portions 137 of the metal leads 13 of the upper semiconductor assembly 110 and the horizontally elongated portions 136 of the metal leads 13 of the lower semiconductor assembly 110.FIG.", "19 is a cross-sectional view of another semiconductor assembly 120 having a semiconductor device 90 electrically coupled to the wiring substrate 100 of FIG.", "7.The semiconductor device 90 includes a routing circuitry 91, a stiffener 93, a first chip 94 and a second chip 95.The routing circuitry 91 is illustrated as a multi-layered buildup circuitry and includes a dielectric layer 911 and wiring layer 913.The dielectric layer 911 typically has a thickness of 50 microns, and can be made of epoxy resin, glass-epoxy, polyimide, or the like.", "The wiring layer 913 typically is made of copper and extends laterally on the dielectric layer 911 and includes conductive vias 914 extending through the dielectric layer 911.In this illustration, the routing circuitry 91 provides first conductive pads 915 and terminal pads 917 at the top surface 901 and second conductive pads 919 at the bottom surface 903.The terminal pads 917 have larger pad size and pitch than those of first conductive pads 915, and the second conductive pads 919 are exposed by an aperture 935 of the stiffener 93 on the bottom surface 903 of the routing circuitry 91.The stiffener 93 may be made of resin, ceramic, metal, composites of metal, or a single or multi-layer circuitry structure which has enough mechanical robustness, and provides mechanical support for the routing circuitry 91.The first chip 94 is electrically coupled to the top surface 901 of the routing circuitry 91, whereas the second chip 95 is disposed in a cavity 907 formed by the bottom surface 903 of the routing circuitry 91 and the interior sidewalls 905 of the aperture 935 of the stiffener 93 and electrically coupled to the bottom surface 909 of the routing circuitry 91.In this embodiment, the first chip 94 is electrically coupled to the first conductive pads 915 of the routing circuitry 91 through first conductive bumps 943, whereas the second chip 95 is electrically coupled to the second conductive pads 919 of the routing circuitry 91 through second conductive bumps 953 and attached to the paddle layer 156.The routing circuitry 91 is electrically connected to the wiring substrate 100 by bonding wires 71 attached to terminal pads 917 of the routing circuitry 91 and the metal leads 13 of the wiring substrate 100.As a result, the first chip 94 and the second chip 95 are electrically connected to each other by the routing circuitry 91, and further electrically connected to the wiring substrate 100 through the bonding wires 71.FIGS.", "20 and 21 are cross-sectional and top perspective views, respectively, of another aspect of the untrimmed wiring substrate according to the first embodiment of the present invention.", "The untrimmed wiring substrate 130 is similar to that illustrated in FIGS.", "7-9, except that it includes no metal film on interior sidewall surfaces of the resin compound 30.As a result, the cavity 305 is formed by the top surface of the metal paddle 156 and the interior sidewall surface of the resin compound 30.FIGS.", "22 and 23 are cross-sectional and top perspective views, respectively, of the structure with a semiconductor device 61 electrically coupled to the wiring substrate 130.The semiconductor device 61 is face-up disposed in the cavity 305 and attached on the metal paddle 156 and electrically coupled to the metal leads 13 of the through bonding wires 71.FIGS.", "24 and 25 are cross-sectional and top perspective views, respectively, of the structure provided with a molding compound 81.Optionally, the molding compound 81 may be further provided to cover and encapsulate the semiconductor device 61 and the bonding wires 71 from above, and further extends into gaps between the semiconductor device 61 and interior sidewalls of the cavity 305.FIGS.", "26, 27 and 28 are cross-sectional, top and bottom perspective views, respectively, of a semiconductor assembly 140 after removal of the metal frame 11.Removal of the metal frame 11 can be done by various methods including chemical etching or mechanical trimming/cutting and sawing.", "By separating the metal frame 11, the connection between the outer ends 131 of the metal leads 13 is broken.", "As a result, the wiring substrate 130 includes the metal leads 13, the metal paddle 156, the tie bars 16 and the resin compound 30.FIGS.", "29 and 30 are cross-sectional and top perspective views, respectively, of a three-dimensional stacked semiconductor package having two semiconductor assemblies 140 of FIGS.", "26-28 electrically connected to each other by solder balls 85.The upper semiconductor assembly 140 is stacked on and electrically coupled to the lower semiconductor assembly 140 by solder balls 85.FIG.", "31 is a cross-sectional view of another semiconductor assembly 150 having a semiconductor device 90 electrically coupled to the wiring substrate 130 of FIG.", "20.The semiconductor device 90 includes a routing circuitry 91, a stiffener 93, a first chip 94 and a second chip 95.In this illustration, the routing circuitry 91 is illustrated as a multi-layered buildup circuitry and includes a dielectric layer 911 and a plurality of wiring layers 113 serially formed in an alternate fashion.", "The first chip 94 is electrically coupled to the routing circuitry 91 from the top surface 901 of the routing circuitry 91, and the second chip 95 is electrically coupled to the routing circuitry 91 from the bottom surface 903 of the routing circuitry 91.In this embodiment, the first chip 94 is electrically coupled to first conductive pads 915 of the routing circuitry 91 through first conductive bumps 943, whereas the second chip 95 is electrically coupled to second conductive pads 919 of the routing circuitry 91 through second conductive bumps 953 and attached to the paddle layer 156.The routing circuitry 91 is electrically connected to the wiring substrate 130 by bonding wires 71 attached to terminal pads 917 of the routing circuitry 91 and the metal leads 13 of the wiring substrate 130.The stiffener 93 covers the bottom surface 903 of the routing circuitry 91 and surrounds and conformally coats and encapsulates the second chip 95.As an alternative, the stiffener 93 may be omitted.", "FIGS.", "32 and 33 are cross-sectional and top perspective views, respectively, of yet another aspect of the trimmed wiring substrate according to the first embodiment of the present invention.", "The wiring substrate 160 of this aspect includes a plurality of metal leads 13, a metal paddle 156, a metal film 158, a plurality of tie bars 16, a resin compound 30 and a top re-distribution layer 51.The metal paddle 156 is thinner than the metal leads 13 and the resin compound 30.The metal film 158 is integral with the metal paddle 156 and made of the same material as the metal paddle 156 and connected with the tie bars 16.The top surface of the metal paddle 156 and the lateral surface of the metal film 158 form a cavity 305.The resin compound 30 provides robust mechanical bonds between the metal leads 13 and bonded to the metal paddle 156 and the metal film 158, and offers a dielectric platform for the top re-distribution layer 51 deposited thereon.", "The top re-distribution layer 51 is formed on the top surface 301 of the resin compound 30 and electrically coupled to the metal leads 13 by metal pattern deposition described below.", "Before forming the cavity 305, the top surface of the structure can be metallized to form an electrically conductive layer (typically a copper layer) as a single layer or multiple layers by numerous techniques, such as electroplating, electroless plating, evaporating, sputtering or their combinations.", "The electrically conductive layer can be made of Cu, Ni, Ti, Au, Ag, Al, their combinations, or other suitable electrically conductive materials.", "Typically, a seeding layer is formed on the topmost surface of the structure prior to the electrically conductive layer is electroplated to a desirable thickness.", "The seeding layer may consist of a diffusion barrier layer and a plating bus layer.", "The diffusion barrier layer is to counterbalance oxidation or corrosion of the electrically conductive layer such as copper.", "In most cases, the diffusion barrier layer also acts as an adhesion promotion layer to the underlying material and is formed by physical vapor deposition (PVD) such as sputtered Ti or TiW with a thickness in a range from about 0.01 μm to about 0.1 μm.", "However, the diffusion barrier layer may be made of other materials, such as TaN, or other applicable materials and its thickness range is not limited to the range described above.", "The plating bus layer is typically made of the same material as the electrically conductive layer with a thickness in a range from about 0.1 μm to about 1 μm.", "For example, if the electrically conductive layer is copper, the plating bus layer would preferably be a thin film copper formed by physical vapor deposition or electroless plating.", "However, the plating bus layer may be made of other applicable materials such as silver, gold, chromium, nickel, tungsten, or combinations thereof and its thickness range is not limited to the range described above.", "Following the deposition of the seeding layer, a photoresist layer (not shown) is formed over the seeding layer.", "The photoresist layer may be formed by a wet process, such as a spin-on process, or by a dry process, such as lamination of a dry film.", "After the photoresist layer is formed, the photoresist layer is patterned to form openings, which are then filled with plated metal such as copper to form the top re-distribution layer 51.The plated metal layer typically has a thickness in a range from about 10 μm to about 100 μm.", "After metal plating, the exposed seeding layer is then removed by etching process to form electrically isolated conductive traces as desired.", "In this illustration, the top re-distribution layer 51 is a top patterned metal layer 515 that has a uniform thickness and laterally extends on the top surface 301 of the resin compound 30 as well as the top sides 101 of the metal leads 13.FIGS.", "34 and 35 are cross-sectional and top perspective views, respectively, of a semiconductor assembly 170 with a semiconductor device 61 and a passive component 65 electrically connected to the wiring substrate 160 illustrated in FIGS.", "32 and 33.The semiconductor device 61 is attached on the metal paddle 156 and electrically coupled to the metal film 158 and the top re-distribution layer 51 through bonding wires 71.The passive component 65 is mounted over the resin compound 30 and electrically coupled to the top re-distribution layer 51.Optionally, a molding compound 81 may be provided to cover and encapsulate the semiconductor device 61 and the bonding wires 71 from above.", "FIG.", "36 is a cross-sectional view of a three-dimensional stacked semiconductor package having two semiconductor assemblies 170 of FIG.", "34 electrically connected to each other by solder balls 85.The upper semiconductor assembly 170 is stacked on and electrically coupled to the lower semiconductor assembly 170 by solder balls 85 in contact with the metal leads 13 of the upper semiconductor assembly 170 and the top re-distribution layer 51 of the lower semiconductor assembly 170.FIG.", "37 is a cross-sectional view of yet another aspect of the untrimmed wiring substrate according to the first embodiment of the present invention.", "The untrimmed wiring substrate 180 is similar to that illustrated in FIG.", "32, except that it further includes an electronic component 20 encapsulated in the resin compound 30 and the metal frame 11 is not yet separated from the metal leads 13.The electronic component 20 is disposed within the metal frame 13 before provision of the resin compound 30.In this embodiment, the electronic component 20 is thinner than the metal leads 13 and the resin compound 30 and has a top side 201 substantially coplanar with the top sides 101 of the metal leads 13 and the top surface 301 of the resin compound 30.The electronic component 20 may be resistors, capacitors, inductors or any other passive or active components.", "The top re-distribution layer 51 laterally extends on the top surface 301 of the resin compound 30 as well as the top sides 101 of the metal leads 13 and the top side 201 of the electronic component 20.As a result, the top re-distribution layer 51 electrically couples the electronic component 20 to the metal leads 13.Embodiment 2 FIGS.", "38-45 are schematic views showing a method of making a wiring substrate having a bottom build-up circuitry in accordance with the second embodiment of the present invention.", "For purposes of brevity, any description in Embodiment 1 is incorporated herein insofar as the same is applicable, and the same description need not be repeated.", "FIGS.", "38 and 39 are cross-sectional and bottom perspective views, respectively, of the structure of FIG.", "4 after removal of the metal frame 11.Removal of the metal frame 11 can be done by various methods including chemical etching or mechanical trimming/cutting.", "By separating the metal frame 11, the connection between the metal leads 13 is broken.", "As a result, the textured metal sheet 10 includes the metal leads 13, the metal slug 15 and the tie bars 16.FIGS.", "40 and 41 are cross-sectional and bottom perspective views, respectively, of the structure with a dielectric layer 531 formed on the textured metal sheet 10 and the resin compound 30 as well as first via openings 533 and second via openings 534 in the dielectric layer 531.The dielectric layer 531 is deposited typically by lamination or coating, and contacts and covers and extends laterally on the textured metal sheet 10 and the resin compound 30 from below.", "After the deposition of the dielectric layer 531, the first via openings 533 and the second via openings 534 are formed by numerous techniques, such as laser drilling, plasma etching and photolithography, and typically have a diameter of 50 microns and extend through the dielectric layer 531.Laser drilling can be enhanced by a pulsed laser.", "Alternatively, a scanning laser beam with a metal mask can be used.", "The first via openings 533 are aligned with selected portions of the metal leads 13, whereas the second via openings 534 are aligned with selected portions of the metal slug 15.FIGS.", "42 and 43 are cross-sectional and bottom perspective views, respectively, of the structure with a bottom patterned metal layer 535 formed on the dielectric layer 531 by metal deposition and metal patterning process.", "The bottom patterned metal layer 535 extends from the metal leads 13 and the metal slug 15 in the downward direction, fill up the first via openings 533 and the second via openings 534 to form first metallized vias 537 and second metallized vias 538 in direct contact with the metal leads 13 and the metal slug 15, respectively, and extend laterally on the dielectric layer 531.As a result, the bottom patterned metal layer 535 can provide horizontal routing in both the X and Y directions and vertical routing through the first via openings 533 and the second via openings 534.At this stage, the formation of a bottom build-up circuitry 53 is accomplished.", "In this illustration, the bottom build-up circuitry 53 includes the dielectric layer 531 and the bottom patterned metal layer 535.FIGS.", "44 and 45 are cross-sectional and top perspective views, respectively, of the structure after selective removal of the metal slug 15.The metal slug 15 is selectively removed to form a cavity 305.The remaining portion of the metal slug 15 consists of a metal paddle 156 and a metal film 158.The metal paddle 156 is located at the bottom of the cavity 305 and thermally conductible to the bottom build-up circuitry 53 through the second metallized vias 538 as heat pipes.", "The metal paddle 156 can also be electrically connected to the metal leads 13 through the bottom build-up circuitry 53 for grounding purpose.", "The metal film 158 is integral with the metal paddle 156 and laterally surrounds the cavity 305.As a result, a wiring substrate 200 is accomplished and includes the metal leads 13, the metal paddle 156, the metal film 158, the tie bars 16, the resin compound 30 and the bottom build-up circuitry 53.FIGS.", "46 and 47 are cross-sectional and top perspective views, respectively, of a semiconductor assembly 210 with a semiconductor device 61 electrically coupled to the wiring substrate 200 and encapsulated by a molding compound 81.The semiconductor device 61 is attached on the metal paddle 156 and electrically coupled to the metal leads 13 and the metal film 158 through bonding wires 71.As a result, the semiconductor device 61 can be thermally conductible to the metal paddle 156 and electrically coupled to the bottom build-up circuitry 53 through the metal leads 13.Optionally, the molding compound 81 may be further provided to cover and encapsulate the semiconductor device 61 and the bonding wires 71 from above.", "FIG.", "48 is a cross-sectional view of a three-dimensional stacked semiconductor package having the semiconductor assembly 110 of FIG.", "14 stacked on the semiconductor assembly 210 of FIG.", "46 by solder balls 85.The upper semiconductor assembly 110 is stacked on and electrically coupled to the lower semiconductor assembly 210 by solder balls 85.Optionally, additional solder balls 87 may be further mounted on the bottom build-up circuitry 53 of the lower semiconductor assembly 210.FIG.", "49 is a cross-sectional view of another semiconductor assembly 220 having a semiconductor device 90 electrically coupled to the wiring substrate 200 of FIG.", "44.The semiconductor device 90 is similar to that illustrated in FIG.", "31, except that it further includes a passive component 97 and a metal pillar 98.The passive component 97 and the metal pillar 98 are electrically coupled to the routing circuitry 91 from the bottom surface 903 of the routing circuitry 91.In this illustration, the second chip 95 is thermally conductible to the metal paddle 156 for heat dissipation, and the metal pillar 98 is electrically connected to the metal paddle 156 for ground connection.", "The routing circuitry 91 is electrically connected to the wiring substrate 200 by bonding wires 71 attached to the routing circuitry 91 of the semiconductor device 90 and the metal leads 13 of the wiring substrate 200.The stiffener 93 also surrounds and conformally coats and encapsulates the passive component 97 and the metal pillar 98.Embodiment 3 FIGS.", "50-61 are schematic views showing a method of making a semiconductor assembly having a semiconductor device attached on a resin paddle in accordance with the third embodiment of the present invention.", "For purposes of brevity, any description in Embodiments above is incorporated herein insofar as the same is applicable, and the same description need not be repeated.", "FIG.", "50 is a cross-sectional view of a textured metal sheet 10.The textured metal sheet 10 is similar to that illustrated in FIGS.", "1-3, except that it includes no tie bars and the metal slug 15 is thinner than the metal frame 11 and the metal leads 13.FIGS.", "51 and 52 are cross-sectional and bottom perspective views, respectively, of the structure provided with a resin compound 30 and a resin paddle 40.The resin compound 30 covers the lower surfaces of the horizontally elongated portions 136 as well as sidewalls of the vertically projected portions 137 and sidewalls of the metal slug 15.The resin paddle 40 covers the bottom side 153 of the metal slug 15 from below and is integral with the resin compound 30.The resin compound 30 and the resin paddle 40 can be integrally formed by applying a resin material into the remaining spaces within the metal frame 11.By planarization, the resin paddle 40 has a bottom surface 403 substantially coplanar with the bottom surface 303 of the resin compound 30 and the bottom sides 103 of the metal frame 11 and the metal leads 13.FIGS.", "53 and 54 are cross-sectional and top perspective views, respectively, of the structure after removal of the metal slug 15.The metal slug 15 is entirely removed to form a cavity 305 and expose the top surface 401 of the resin paddle 40 from the cavity 305.At this stage, an untrimmed wiring substrate 300 is accomplished and includes the metal frame 11, the metal leads 13, the resin compound 30 and the resin paddle 40.FIGS.", "55 and 56 are cross-sectional and top perspective views, respectively, of the structure with a semiconductor device 61 electrically coupled to the wiring substrate 300.The semiconductor device 61 is face-up disposed in the cavity 305 and attached on the resin paddle 40 and electrically coupled to the metal leads 13 through bonding wires 71.FIGS.", "57 and 58 are cross-sectional and top perspective views, respectively, of the structure provided with a molding compound 81.Optionally, the molding compound 81 may be further provided to cover and encapsulate the semiconductor device 61 and the bonding wires 71 from above.", "FIGS.", "59, 60 and 61 are cross-sectional, top and bottom perspective views, respectively, of a semiconductor assembly 310 after removal of the metal frame 11.Removal of the metal frame 11 can be done by various methods including chemical etching or mechanical trimming/cutting.", "By separating the metal frame 11, the connection between the metal leads 13 is broken.", "As a result, the wiring substrate 300 includes the metal leads 13, the resin compound 30 and the resin paddle 40.FIGS.", "62 and 63 are cross-sectional and top perspective views, respectively, of a three-dimensional stacked semiconductor package having two semiconductor assemblies 310 of FIG.", "59 electrically connected to each other by solder balls 85.The upper semiconductor assembly 310 is stacked on and electrically coupled to the lower semiconductor assembly 310 by solder balls 85.FIG.", "64 is a cross-sectional view of another semiconductor assembly 320 having a semiconductor device 90 electrically coupled to the wiring substrate 300 of FIG.", "53 through bonding wires 71.The semiconductor device 90 is similar to that illustrated in FIG.", "49, except that (i) the first chip 94 is electrically connected to the routing circuitry 91 by bonding wires 945, (ii) a third chip 96 is further provided and electrically coupled to the routing circuitry 91 through third conductive bumps 963, and (iii) no metal pillar 98 is encapsulated in the stiffener 93.As a result, the first chip 94, the second chip 95 and the third chip 96 can be electrically connected to the wiring substrate 300 through the routing circuitry 91 and the bonding wires 71 attached to the routing circuitry 91 and the metal leads 13.FIG.", "65 is a cross-sectional view of another aspect of the wiring substrate according to the third embodiment of the present invention.", "The wiring substrate 330 of this aspect includes a plurality of metal leads 13, a resin compound 30, a resin paddle 40 and a top re-distribution layer 51.The top surface of the resin paddle 40 and the interior sidewall surface of the resin compound 30 form a cavity 305.The top re-distribution layer 51 is formed on the top surface 301 of the resin compound 30 and electrically coupled to the metal leads 13.In this illustration, the top re-distribution layer 51 is a top patterned metal layer 515.FIG.", "66 is a cross-sectional view of yet another aspect of the wiring substrate according to the third embodiment of the present invention.", "The wiring substrate 340 is similar to that illustrated in FIG.", "65, except that it further includes a metal layer 46 on the top surface of the resin paddle 40.In this aspect, the metal layer 46 is formed by selectively removing the metal slug 15 illustrated in FIG.", "51 and leaving a remaining portion of the metal slug 15 on the resin paddle 40.FIG.", "67 is a cross-sectional view of yet another aspect of the wiring substrate according to the third embodiment of the present invention.", "The wiring substrate 350 is similar to that illustrated in FIG.", "66, except that it further includes a metal film 48 on the interior sidewall surface of the resin compound 30 and a bottom build-up circuitry 53 on the bottom surface 303 of the resin compound 30 and the bottom surface 403 of the resin paddle 40 and electrically coupled to the metal leads 13.The metal layer 46 and the metal film 48 are integral with each other and formed by selectively removing the metal slug 15 illustrated in FIG.", "51 to leave remaining portions of the metal slug 15 on the top surface of the resin paddle 40 and the interior sidewall surface of the resin compound 30.In this illustration, the bottom build-up circuitry 53 includes a dielectric layer 531 and a bottom patterned metal layer 535 in an alternate fashion.", "The dielectric layer 531 contacts and covers and extends laterally on the metal leads 13, the resin compound 30 and the resin paddle 40 from below.", "The bottom patterned metal layer 535 extends laterally on the dielectric layer 531 and includes first metallized vias 537 in contact with the metal leads 13.FIG.", "68 is a cross-sectional view of a semiconductor assembly 360 with a semiconductor device 61 and a passive component 65 electrically connected to the wiring substrate 350 of FIG.", "67.The semiconductor device 61 is attached on the metal layer 46 and electrically coupled to the top re-distribution layer 51 through bonding wires 71.Accordingly, the semiconductor device 61 can be connected to the bottom build-up circuitry 53 through the bonding wires 71, the top re-distribution layer 51 and the metal leads 13.The passive component 65 is mounted over the resin compound 30 and electrically coupled to the top re-distribution layer 51.Optionally, a molding compound 81 may be provided to cover and encapsulate the semiconductor device 61, the passive component 65 and the bonding wires 71 from above.", "As illustrated in the aforementioned embodiments, a distinctive wiring substrate is configured to have a cavity surrounded by metal leads.", "The wiring substrate of the present invention includes: a plurality of metal leads each having an inner end directed toward a predetermined area and an outer end situated farther away from the predetermined area than the inner end; a resin compound that fills in spaces between the metal leads and laterally extends beyond the inner ends of the metal leads and into the predetermined area to surround a cavity at the predetermined area, wherein the resin compound has a top surface substantially coplanar with top sides of the metal leads; and a paddle layer that is located adjacent to a bottom of the cavity and thinner than resin compound and the metal leads and has a bottom surface substantially coplanar with that of the resin compound.", "In a preferred embodiment, the metal leads are separated from a metal frame and can serve as horizontal and vertical signal transduction pathways or provide ground/power plane for power delivery and return; the resin compound surrounds the cavity and is bonded to the metal leads and has an interior sidewall surface extending beyond the top surface of the paddle layer; the cavity is formed by selectively or entirely removing a metal slug; and the paddle layer may be a metal paddle or a resin paddle and covers the bottom of the cavity and is surrounded by the resin compound.", "Each of the metal leads preferably is an integral one-piece lead and can be separated from a metal frame after provision of the resin compound.", "The metal leads separated from the metal frame have top and bottom sides and an exterior lateral surface perpendicular to the top and bottom sides and not covered by the resin compound.", "In a preferred embodiment, the metal leads have a thickness in a range from about 0.15 mm to about 1.0 mm and laterally extend at least to a perimeter coincident with peripheral edges of the resin compound.", "For secure bonds between the metal leads and the resin compound, the metal leads may have stepped peripheral edges interlocked with the resin compound.", "As a result, the resin compound also has a stepped cross-sectional profile where it contacts the metal leads so as to prevent the metal leads from being vertically forced apart from the resin compound and also to avoid micro-cracking at the interface along the vertical directions.", "The resin compound can be bonded to the metal leads by paste printing, compressive molding, transfer molding, liquid injection molding, spin coating, or other suitable methods.", "Preferably, the resin compound has a top surface substantially coplanar with the top sides of the metal leads, and a bottom surface substantially coplanar with the bottom sides of the metal leads.", "Further, the resin compound may have an elastic modulus larger than 1.0 GPa, a linear coefficient of thermal expansion in a range from about 5×10−6 K−1 to about 15×10−6 K−1.Additionally, for sufficient thermal conductivity and suitable viscosity, the resin compound may include thermally conductive fillers in a range of 10 to 90% by weight.", "For instance, the thermally conductive fillers may be made of aluminum nitride (AlN), aluminum oxide, silicon carbide (SiC), tungsten carbide, boron carbide, silica or the like and preferably has relatively high thermal conductivity, high electrical resistance, and a relatively low CTE.", "Accordingly, the resin compound would exhibit improved heat dissipation performance, electrical isolation performance and shows inhibition of delamination or cracking of the top re-distribution layer deposited thereon or interfaces due to low CTE.", "Additionally, the maximum particle size of the thermally conductive fillers may be 25 μm or less.", "The paddle layer can be made of a metal material or a resin material.", "For instance, in a thermally enhanced case, the metal slug within the metal frame is selectively removed after provision of the resin compound to leave a remaining portion of the metal slug as a metal paddle that is made of the same material as the metal leads and has peripheral edges boned to the resin compound and a bottom surface substantially coplanar with that of the resin compound and the metal leads.", "Accordingly, the cavity can have a metallic bottom as a thermal dissipation platform or/and a vertical EMI (electromagnetic interference) shield for a semiconductor device attached thereon, so that the heat generated by the semiconductor device can be conducted away through the metallic paddle layer and/or vertical EMI can be reduced.", "Optionally, the step of selectively removing the metal slug may further include leaving an additional remaining portion of the metal slug on the interior sidewall surface of the resin compound.", "As a result, the interior sidewall surface of the resin compound can be completely covered by a metal film integral with the metal paddle, and the cavity has metallic sidewalls for providing horizontal EMI (electromagnetic interference) shielding for the semiconductor device disposed in the cavity.", "As an alternative case, the metal slug may be thinner than the metal leads and the resin compound, and the step of providing the resin compound includes providing a resin paddle as the paddle layer on a bottom side of the metal slug.", "In a preferred embodiment, the resin paddle is integral with the resin compound and made of the same material as that of the resin compound and has a bottom surface substantially coplanar with that of the resin compound and the metal leads.", "The resin paddle and the resin compound can be integrally formed by, for example, a molding process of a resin material.", "Optionally, the top surface of the resin paddle may be further covered by a remaining portion of the metal slug, and the combined thickness of the resin paddle and the remaining portion of the metal slug is less than that of the resin compound.", "Accordingly, the remaining portion of the metal slug can offer a thermal dissipation platform or/and vertical EMI shielding for a semiconductor device attached thereon.", "Likewise, the interior sidewall surface of the resin compound may be further covered by an additional remaining portion of the metal slug to provide vertical EMI shielding for the semiconductor device disposed in the cavity.", "Optionally, a top re-distribution layer may be further deposited on the top surface of the resin compound and electrically coupled to the metal leads to increase routing flexibility of the wiring substrate.", "The top re-distribution layer may be a top patterned metal layer formed by metal deposition using photolithographic process and having a uniform thickness less than the thickness of the metal leads.", "In a preferred embodiment, the top patterned metal layer contacts and laterally extends on the top surface of the resin compound and further laterally extends onto the top sides of the metal leads by a sputtering process and then an electrolytic plating process.", "As a result, the top re-distribution layer can provide electrical contacts on the resin compound for device connection.", "Optionally, an electronic component may be further provided to be encapsulated in the resin compound and electrically connected to the metal leads through the top re-distribution layer.", "In a preferred embodiment, the electronic component is thinner than the metal leads and has a top side electrically coupled to the top re-distribution layer and a bottom side covered by the resin compound.", "The electronic component may be a resistor, capacitor, inductor or any other passive or active component.", "Optionally, a bottom build-up circuitry may be further deposited on the bottom surface of the resin compound and electrically connected to the top re-distribution layer through the metal leads.", "By double routing circuitries on two sides of the resin compound, the routing flexibility of the wiring substrate can be enhanced.", "In a preferred embodiment, the bottom build-up circuitry includes at least one dielectric layer and at least one bottom patterned metal layer extending through the dielectric layer and extending laterally on the dielectric layer.", "The dielectric layer and the bottom patterned metal layer are serially formed in an alternate fashion and can be in repetition when needed.", "Accordingly, the bottom build-up circuitry can be electrically coupled to the metal leads and thermally conductible to the metallic paddle layer through metallized vias in the dielectric layer.", "The present invention also provides a semiconductor assembly in which a semiconductor device is electrically connected to the aforementioned wiring substrate.", "Specifically, the semiconductor device can be face-up disposed over the top surface of the paddle layer and electrically connected to the metal leads by bonding wires attached to the metal leads or the top re-distribution layer.", "In a thermally enhanced case, the semiconductor device is attached on the remaining portion of the metal slug, and may be further electrically coupled to the additional remaining portion of the metal slug on the interior sidewall surface of the resin compound through at least one bonding wire for ground connection.", "The assembly can be a first-level or second-level single-chip or multi-chip device.", "For instance, the assembly can be a first-level package that contains a single chip or multiple chips.", "Alternatively, the assembly can be a second-level module that contains a single package or multiple packages, and each package can contain a single chip or multiple chips.", "The semiconductor device can be a packaged or unpackaged chip.", "For instance, the semiconductor device can be a bare chip, or a wafer level packaged die, etc.", "Alternatively, the semiconductor device may include a routing circuitry, a first chip and a second chip.", "The first chip can be electrically coupled to a top surface of the routing circuitry by a well-known flip chip bonding process with its active surface facing in the routing circuitry using conductive bumps without metallized vias in contact with the first chip, or by wire bonding process with its active surface facing away the routing circuitry using bonding wires.", "Likewise, the second chip can be electrically coupled to a bottom surface of the routing circuitry by a well-known flip chip bonding process with its active surface facing in the routing circuitry using conductive bumps without metallized vias in contact with the second chip.", "Optionally, the semiconductor device may further include a stiffener bonded to the routing circuitry and laterally surrounding the second chip.", "The routing circuitry can be a buildup circuitry without a core layer to provide primary fan-out routing/interconnection and the shortest interconnection distance between the first and second chips.", "Preferably, the routing circuitry is a multi-layered buildup circuitry and includes at least one dielectric layer and at least one wiring layer that extend laterally on the dielectric layer and has conductive vias in the dielectric layer.", "The dielectric layer and the wiring layer are serially formed in an alternate fashion and can be in repetition when needed.", "Accordingly, the routing circuitry can be formed with first conductive pads and optionally terminal pads at its top surface and second conductive pads at its bottom surface.", "The first conductive pads and the terminal pads can be electrically connected to the second conductive pads through conductive vias.", "Further, the terminal pads are electrically connected to the metal leads or the top re-distribution layer of the wiring substrate.", "In a preferred embodiment, the terminal pads for bonding wire connection and have larger pad size and pad pitch than those of the first conductive pads, the second conductive pads and I/O pads of the first and second chips.", "The optional stiffener laterally extends to peripheral edges of the routing circuitry to provide mechanical support for the routing circuitry.", "The stiffener can conformally coat and encapsulate the second chip, or have an aperture aligned with the second conductive pads to expose the second conductive pads of the routing circuitry.", "Accordingly, the bottom surface of the routing circuitry and interior sidewall surfaces of the aperture of the stiffener can form a cavity in the aperture of the stiffener, and the second chip can be disposed in the cavity and have peripheral edges spaced from the interior sidewall surfaces of the aperture of the stiffener and be electrically coupled to the second conductive pads.", "In a preferred embodiment, the stiffener has a thickness substantially equal to the combined thickness of the second chip and the second conductive pads.", "The term “cover” refers to incomplete or complete coverage in a vertical and/or lateral direction.", "For instance, the resin compound covers sidewalls of the metal leads regardless of whether another element is between the metal leads and the resin compound.", "The phrases “attached to” and “attached on” include contact and non-contact with a single or multiple support element(s).", "For instance, in a preferred embodiment, the semiconductor device can be attached to the resin paddle regardless of whether the semiconductor device is separated from the resin paddle by the metal layer.", "The phrases “electrical connection”, “electrically connected” and “electrically coupled” refer to direct and indirect electrical connection.", "For instance, in a preferred embodiment, the semiconductor device can be electrically connected to the metal leads by the bonding wires but does not contact the metal leads.", "The wiring substrate according to the present invention has numerous advantages.", "The metal paddle establishes a heat dissipation pathway for spreading out the heat generated by the semiconductor device.", "The resin compound provides robust mechanical bonds between the metal leads, and offers a dielectric platform for the top re-distribution layer and/or the bottom build-up circuitry deposited thereon.", "The metal leads provide primary horizontal and vertical routing, and the top re-distribution layer and the bottom build-up circuitry offer further routing to increase routing flexibility of the wiring substrate.", "The wiring substrate made by this method is reliable, inexpensive and well-suited for high volume manufacture.", "The manufacturing process is highly versatile and permits a wide variety of mature electrical and mechanical connection technologies to be used in a unique and improved manner The manufacturing process can also be performed without expensive tooling.", "As a result, the manufacturing process significantly enhances throughput, yield, performance and cost effectiveness compared to conventional techniques.", "The embodiments described herein are exemplary and may simplify or omit elements or steps well-known to those skilled in the art to prevent obscuring the present invention.", "Likewise, the drawings may omit duplicative or unnecessary elements and reference labels to improve clarity." ] ]
Patent_15872828
[ [ "VEHICLE ROLLOVER SAFETY DEVICE UTILIZING A CIRCULAR ARC LEVEL", "A vehicle safety rollover device utilizing a circular arc level for detecting vehicle rollover is disclosed.", "Upon detection, the device automatically shuts-off power to an ignition system and notifies for shut-down of the electrical system of the vehicle.", "The circular arc level is capable of measuring gravitational norm deviation while remaining impervious to the effects of acceleration, deceleration, impact, and centripetal forces." ], [ "1.A vehicle safety rollover device, that upon detection of a vehicle rollover, automatically shuts-off power to an ignition system of said vehicle and notifies need to shut down an electrical system of said vehicle, said device comprising: (a) a power input; (b) a ground input (105) operatively connected to a vehicle common ground; (c) a first latching relay switch (103) and a second latching relay switch (117), each comprising: (i) an input, (ii) a first output position, (iii) a second output position, (iv) a set pin, and (v) a reset pin, wherein each latching relay switch is initially in the first output position, wherein each latching relay switch switches from the first output position to the second output position when power is supplied to the set pin, wherein each reset pin is connected to the ground input (105); (d) an ignition start input (111) operatively connected to the input of the first latching relay switch (103); (e) an ignition start output (115) operatively connected to the first output position of the first latching relay switch (103); (f) an electrical shut-off signal (112) operatively connected to the second output position of the second latching relay switch (117), wherein the input of the second latching relay switch (117) is operatively connected to the power input; and (g) a circular arc level (200), herein referred to as a CAL sensor (200), comprising an arcuate tube (201) having light emitters and detectors coupled to an exterior of the arcuate tube (201), the CAL sensor (200) configured to supply power to each set pin when the CAL sensor (200) is activated.", "wherein initially, power flows through the first latching relay switch (103) to an ignition starter of the ignition system, wherein the second latching relay switch (117) disconnects the electrical shutoff signal (112) from the power input, wherein when the CAL sensor (200) is activated, power flows from the power input to each set pin, causing the first (103) and the second (117) latching relay switches to switch from the first output position to the second output position, whereupon switching, power to the ignition starter is disconnected, wherein power then flows to the electrical shutoff signal (112) via the second latching relay switch (117), thereby causing the electrical system of the vehicle to shut down.", "2.The device of claim 1, wherein the power is supplied from a battery power (108).", "3.The device of claim 1, wherein the power is supplied from an alternator power (104).", "4.The device of claim 1, wherein the power is supplied from an alternator power (104) and a battery power (108).", "5.The device of claim 4 further comprising a conductive pin operatively connected to the battery power (108).", "6.The device of claim 5 further comprising a transistor (133) comprising a base pin, a collector pin, and an emitter pin, wherein the collector pin is connected to the alternator power (104), wherein the emitter pin is connected to all four latching relay switches (103), (117), (102), and (101).", "7.The device of claim 6 further comprising a switch operatively coupling conductive pin and the base pin, wherein the switch is normally open.", "8.The device of claim 1, wherein a liquid partially fills the arcuate tube (201), wherein an air bubble (203) is disposed in the arcuate tube (201) such that the liquid and the air bubble (203) fill the arcuate tube (201), wherein the CAL sensor (200) is fixed to the body of the vehicle, wherein the CAL sensor (200) is in an upright position relative to gravity when an inclination of the CAL sensor (200) is zero, wherein when the CAL sensor (200) is in the upright position, the air bubble (203) is in a resting position at an apex of the arcuate tube (201).", "9.The device claim 8 wherein the light emitters comprise: (a) a first light emitting element (205) disposed on the exterior of the arcuate tube (201) at a first location about 75°-90° from the apex of the arcuate tube (201), wherein the first light emitting element (205) emits a first optical signal; and (b) a second light emitting element (207) disposed on the exterior of the arcuate tube (201) at a second location about 270°-285° from the apex of the arcuate tube (201), wherein the second light emitting element (207) emits a second optical signal.", "10.The device of claim 9, wherein the detectors comprise: (a) a first photodetector (209) disposed on the exterior of the arcuate tube (201) at a third location about 75°-90° from the apex of the arcuate tube (201), wherein the third location is opposite the first location such that the arcuate tube (201) is disposed between the first photodetector (209) and the first light emitting element (205), wherein the first photodetector (209) is positioned to detect the first optical signal; and (b) a second photodetector (211) disposed on the exterior of the arcuate tube (201) at a fourth location about 270°-285° from the apex of the arcuate tube (201), wherein the fourth location is opposite the second location such that the arcuate tube (201) is disposed between the second photodetector (211) and the second light emitting element (207), wherein the second photodetector (211) is positioned to detect the second optical signal; wherein when the CAL sensor (200) is in the upright position, the liquid blocks detection of the first optical signal and the second optical signal, wherein at an inclination of the CAL sensor (200) within a first threshold window, centered between about 75° and 90° from the apex of the arcuate tube (201), the air bubble (203) travels from the resting position to a position between the first photodetector (209) and the first light emitting element (205) thus activating the CAL sensor (200) by permitting detection of the first optical signal, whereupon detecting the first optical signal, the first photodetector (209) transmits a first signal that activates the switch to close thereby forming a closed circuit, which allows current to flow through the conductive pin to the base pin to open an electrical path from the battery power to each set pin, wherein when the CAL sensor (200) is tilted within a second threshold window, centered between about 270° and 285° from the apex of the arcuate tube (201), the air bubble (203) travels from the resting position to a position between the second photodetector (211) and the second light emitting element (207) thus activating the CAL sensor (200) by permitting detection of the second optical signal, whereupon detecting the second optical signal, the second photodetector (211) transmits a second signal that activates the switch to close thereby forming a closed circuit, which allows current to flow through the conductive pin to the base pin to open an electrical path from the battery power to each set pin.", "11.The device of claim 4 further comprising a third latching relay switch (101) and fourth latching relay switch (102) each comprising: (a) an input, (b) a first output position, (c) a second output position, (d) a set pin, and (e) a reset pin, wherein each latching relay switch is initially the first output position, wherein each latching relay switch switches from the first output position to the second output position when power is supplied to the set pin, wherein each reset pin is connected to the ground input (105).", "12.The device of claim 11 further comprising a first ignition switch motor-on input (110), operatively connected to the input of the third latching relay switch (101), and a second ignition switch motor-on input (110), connected to the input of the fourth latching relay switch (102).", "13.The device of claim 12 further comprising a first ignition switch motor-on output (113), operatively connected to the first output of the third latching re witch (101), and a second ignition switch motor-on output (114), operatively connected to the first output of the fourth latching relay switch (102).", "14.The device of claim 13, wherein initially, the alternator power (104) flows through the third (101) and fourth (102) latching relay switch to the first (110) and the second (110) ignition switch motor-on input, wherein when the CAL sensor (200) is activated, power flows from the power input to the set pins of the first (103), the second (117), the third (101), and the fourth (102) latching relay switches, causing each relay switch to switch from the first output position to the second output position, wherein power to the first ignition switch motor-on input (110), the second ignition switch motor-on input (110), and the ignition starter is disconnected, wherein power flows to the electrical shutoff signal (112), thereby causing: the electrical system of the vehicle to shut down, a disabling of all accessories, a notifying of an overseeing computer, a summoning of an emergency response and/or a depressurization of one or more fuel lines.", "15.A circular arc level sensor (200), herein referred to as a CAL sensor (200), for detecting an inclination of a body, the CAL sensor (200) comprising: a) an arcuate tube (201), wherein a liquid partially fills the arcuate tube (201), wherein an air bubble (203) is disposed in the arcuate tube (201) such that the liquid and the air bubble (203) fill the arcuate tube (201), wherein the CAL sensor (200) is fixed to the body of the vehicle, wherein the CAL sensor (200) is in an upright position relative to gravity when an inclination of the CAL sensor (200) is zero, wherein when the CAL sensor (200) is in the upright position, the air bubble (203) is in a resting position at an apex of the arcuate tube (201); (b) a first light emitting element (205) disposed on an exterior of the arcuate tube (201) at a first location about 75°-90° from the apex of the arcuate tube (201), wherein the first light emitting element (205) emits a first optical signal; (c) a second light emitting element (207) disposed on the exterior of the arcuate tube (201) at a second location about 270°-285° from the apex of the arcuate tube (201), wherein the second light emitting element (207) emits a second optical signal; (d) a first photodetector (209) disposed on the exterior of the arcuate tube (201) at a third location about 75°-90° from the apex of the arcuate tube (201), wherein the third location is opposite the first location such that the arcuate tube (201) is disposed between the first photodetector (209) and the first light emitting element (205), wherein the first photodetector (209) is positioned to detect the first optical signal; and (e) a second photodetector (211) disposed on the exterior of the arcuate tube (201) at a fourth location about 270°-285° from the apex of the arcuate tube (201), wherein the fourth location is opposite the second location such that the arcuate tube (201) is disposed between the second photodetector (211) and the second light emitting element (207), wherein the second photodetector (211) is positioned to detect the second optical signal; and wherein when the CAL sensor (200) is in the upright position, the liquid blocks detection of the first optical signal and the second optical signal, wherein when the CAL sensor (200) is tilted within a first threshold window, centered at about 75°-5° from the apex of the arcuate tube (201), the air bubble (203) travels to rest between the first and third location permitting the first optical signal to travel through the air bubble (203) to the first photodetector (209) for detection, thus sensing the inclination, wherein when the CAL sensor (200) is tilted within a second threshold window, centered about 270°-285° from the apex of the arcuate tube (201), the air bubble (203) travels to rest between the second and fourth location permitting the second optical signal to travel through the air bubble (203) to the second photodetector (211) for detection, thus sensing the inclination.", "16.A vehicle safety rollover device, that upon detection of a vehicle rollover, automatically shuts-off power to an ignition system of said vehicle and notifies need to shut down an electrical system of said vehicle, said device comprising: (a) an ignition control relay (517) having a first latching relay switch (103) and a second latching relay switch (117); (b) a sensor (200) configured to supply power to the first latching relay switch (103) and the second latching relay switch (117) when the sensor (200) is activated; wherein when the sensor (200, 510) is activated, power flows from the power input to a set pin of each of the first latching relay switch and the second latching relay switch, causing the first latching relay switch (103) and the second (117) latching relay switches to switch from a first output position to a second output position, whereupon switching, power to the ignition starter is disconnected, wherein power then flows to an electrical shutoff signal (112) via the second latching relay switch (117), thereby causing the electrical system of the vehicle to shut down.", "17.The vehicle safety rollover device of claim 16, further comprising a photo optic circuitry (516) coupled to the sensor (200) that controls one or more photo optic components of the sensor (200)." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Rollover crashes are one of the most significant safety problem for all classes of light vehicles especially light trucks (pickups, sport utility vehicles, and vans—LTVs).", "For 1992 through 1996, there was an average of approximately 227,000 rollover crashes per year.", "(Rollover crashes are ones in which rollover is the first harmful event.)", "These rollovers resulted in an average of 9,063 fatalities per year (29 percent of all light vehicle fatalities) and over 200,000 non-fatal injuries per year.", "In terms of fatalities per registered vehicle, rollovers are second only to frontal crashes in their level of severity.", "The rollover problem is more serious for light trucks, especially sport utility vehicles.", "State crash data indicates that, for all types of collisions, LTV's are in 68 percent as many crashes per registered vehicle as are passenger cars.", "A major problem in rollover accidents is the release of fuel, which can trigger a fire and greatly increase the injury and fatality rate in rollover accidents.", "Thus, a goal of vehicle safety is to disable the fuel pump and engine when a rollover occurs as well as electrical sources of ignition such as the starter and electrical system.", "Disabling the starter and electrical system reduces the chances of igniting a fire if fuel escapes.", "In the US alone and at the start of 2014, there exist approximately 241 million registered passenger vehicles without rollover safety.", "In 2014, it is expected that an additional 16 to 17 million more will be added to the tally.", "The present invention describes a rollover detection device effective for providing rollover safety to all vehicles having an electric fuel pump.", "Any feature or combination of features described herein are included within the scope of the present invention provided that the features included in any such combination are not mutually inconsistent as will be apparent from the context, this specification, and the knowledge of one of ordinary skill in the art.", "Additional advantages and aspects of the present invention are apparent in the following detailed description and claims." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The invention comprises a rollover safety device that automatically shuts off both the engine and electric fuel pump the instant a vehicle rolls or flips over a critical angle in any direction.", "The angles used to determine excessive tilt, or inclination, tend to vary by vehicle application.", "For instance, box shaped vehicles typically tip on their sides but rarely continue to roll over.", "The safety device can be configured to trigger at a desired angle of inclination depending on the vehicle type.", "The safety device is designed to be resectable with manufacturer support after such an accident.", "Once set due to a rollover, the safety device remains set, independent of power, until reset by a trained technician.", "By shutting off power to the fuel pump and starter, and shutting off the engine, the invention can reduce fires and explosions resulting from severe rollover accidents.", "In addition to saving lives, by reducing the hazards of rollover accidents, liability claims from rollover accidents can be reduced.", "The invention is relatively simple and cost-effective to construct, and is advantageous by not requiring power to keep the engine and fuel pump inoperative.", "According to one embodiment, the subject disclosure features a vehicle safety rollover device that, upon detection of a vehicle rollover, automatically shuts-off power to an ignition system of said vehicle and shuts down the electrical system and fuel pump of the vehicle.", "In some embodiments, the safety device comprises a power input, a ground input, a first latching relay switch, and a second latching relay switch.", "The ground input may be operatively connected to a vehicle common ground.", "In other embodiments, the first and second latching relay switches each comprise: an input, a first output position, a second output position, a set pin, and a reset pin, which is also connected to the ground input.", "The first output position is the initial position of each latching relay switch.", "When power is supplied to the set pin, the respective latching relay switch switches to the second output position.", "In further embodiments, the safety device additionally comprises an ignition start input, an ignition start output, and an electrical shut-off signal.", "The ignition start input may be operatively connected to the input of the first latching relay switch, while the ignition start output may be operatively connected to the first output position of the first latching relay switch.", "Further, the electrical shut-off signal may be operatively connected to the second output position of the second latching relay switch, where the input of the second latching relay switch may be operatively connected to the power input.", "In additional embodiments, the safety device employs a circular arc level, herein referred to as a CAL sensor, to detect an inclination of the vehicle.", "In some embodiments, the CAL sensor comprises an arcuate tube partially filled with a liquid.", "An air bubble is disposed in the arcuate tube such that the liquid and the air bubble fill the arcuate tube.", "In an embodiment, the air bubble rests at an apex of the arcuate tube when an inclination of the CAL sensor is zero.", "In other embodiments, the CAL sensor also comprises a first and second light emitting element each disposed on the exterior of the arcuate tube.", "In other embodiments, the first light emitting element is disposed at a first location about 75°-90° from the apex of the arcuate tube and emits a first optical signal.", "The second light emitting element is disposed at a second location about 270°-285° from the apex of the arcuate tube and emits a second optical signal.", "In supplementary embodiments, the CAL sensor may further comprise a first and second photodetector each disposed on the exterior of the arcuate tube.", "The first photodetector is disposed at a third location about 75°-90° from the apex of the arcuate tube, where the third location is opposite the first location such that the arcuate tube is disposed between the first light emitting element and the first photodetector.", "The first photodetector is positioned to detect the first optical signal when the air bubble is positioned between them.", "Additionally, the second photodetector is disposed at a fourth location about 270°-285° from the apex of the arcuate tube, where the fourth location is opposite the second location such that the arcuate tube is disposed between the second light emitting element and the second photodetector.", "The second photodetector is positioned to detect the second optical signal when the air bubble is positioned between them.", "Non-limiting examples of light emitting elements are light emitting diodes (LEDS).", "The liquid disposed in the arcuate tube is selected to prohibit detection of the first and second optical signals by the first and second photodetectors, respectively.", "For example, the liquid may be black to absorb all visible light signals emitted by the light emitting elements.", "As another example, the liquid may be green or yellow to block a red light signal.", "As can be understood by one of ordinary skill in the art, many such combinations exist.", "In supplementary embodiments, a conductive pin, a transistor, and a normally open switch additionally comprise the safety device.", "The conductive pin may be operatively connected to the battery power.", "The transistor may comprise a base pin, a collector pin, and an emitter pin.", "In an embodiment, the collector pin is connected to the alternator power while the emitter pin is connected to the first and second latching relay switches.", "In another embodiment, the base pin is connected to the conductive pin via the switch.", "The switch is operatively coupled to the first and second photodetector such that a first signal sent from the first photodetector ( 209 ) or a second signal sent from the second photodetector activates the switch to close.", "Consistent with previous embodiments, the CAL sensor is fixed to the body of the vehicle.", "When the CAL sensor is in an upright position relative to gravity, the air bubble rests at an initial position at the apex of the arcuate tube and the liquid is blocking detection of the first optical signal and the second optical signal.", "At an inclination of the CAL sensor within a first threshold window, centered at about 75°-90° from the apex of the arcuate tube, the air bubble travels from the initial position to rest between the first photodetector and the first light emitting element, thus activating the CAL sensor by permitting detection of the first optical signal.", "Upon detection of the first optical signal, the first photodetector transmits a first signal that activates the switch to close.", "In this way, a circuit is formed to allow current to flow through the conductive pin to the base pin, opens an electrical path from the battery power to each set pin.", "Additionally, at an inclination of the CAL sensor within a second threshold window, centered at about 270°-285° from the apex of the arcuate tube, the air bubble travels from the initial position to rest between the second photodetector and second light emitting element, thus activating the CAL sensor by permitting detection of the second optical signal.", "Upon detection of the second optical signal, the second photodetector transmits a second signal that activates the switch to close.", "In this way, a closed circuit is formed to allow current to flow through the conductive pin to the base pin, which opens an electrical path from the battery power to each set pin.", "At an application of the battery power to each set pin, the first and second latching relay switches switch from the first output position to the second output position, thus disconnecting power to the ignition starter.", "Moreover, power then flows to the electrical shutoff signal, via the second latching relay switch, thereby causing the electrical system of the vehicle to shut down.", "One of the unique and inventive technical features of the present invention is the implementation of a circular arc level sensor to detect vehicle rollover.", "Without wishing to limit the invention to any theory or mechanism, it is believed that the CAL sensor advantageously provides for an improved detection as a result of its lack of mass affected by centripetal or impact forces.", "Moreover, the CAL sensor employed in the present invention yields the most cost effective solution for sensing rollover.", "Since a single air bubble works in both directions simultaneously, only one CAL sensor is required for roll, and one for flip, if flip is necessary.", "The CAL sensor minimizes the potential of false triggering, provided that adequate debounce delay is created.", "Furthermore, the CAL sensor is self-resetting." ], [ "CROSS REFERENCE This application claims priority to U.S. patent application No.", "62/516,351, filed Jun.", "7, 2017 and U.S. Non-provisional application Ser.", "No.", "14/944,818, filed Nov. 18, 2015, which claims priority to U.S. Patent Application No.", "62/081,127, filed Nov. 18, 2014, the specification(s) of which is/are incorporated herein in their entirety by reference.", "FIELD OF THE INVENTION The present invention relates to automobile safety, namely, a rollover safety device employing a circular arc level for detecting when a vehicle rolls or flips over.", "BACKGROUND OF THE INVENTION Rollover crashes are one of the most significant safety problem for all classes of light vehicles especially light trucks (pickups, sport utility vehicles, and vans—LTVs).", "For 1992 through 1996, there was an average of approximately 227,000 rollover crashes per year.", "(Rollover crashes are ones in which rollover is the first harmful event.)", "These rollovers resulted in an average of 9,063 fatalities per year (29 percent of all light vehicle fatalities) and over 200,000 non-fatal injuries per year.", "In terms of fatalities per registered vehicle, rollovers are second only to frontal crashes in their level of severity.", "The rollover problem is more serious for light trucks, especially sport utility vehicles.", "State crash data indicates that, for all types of collisions, LTV's are in 68 percent as many crashes per registered vehicle as are passenger cars.", "A major problem in rollover accidents is the release of fuel, which can trigger a fire and greatly increase the injury and fatality rate in rollover accidents.", "Thus, a goal of vehicle safety is to disable the fuel pump and engine when a rollover occurs as well as electrical sources of ignition such as the starter and electrical system.", "Disabling the starter and electrical system reduces the chances of igniting a fire if fuel escapes.", "In the US alone and at the start of 2014, there exist approximately 241 million registered passenger vehicles without rollover safety.", "In 2014, it is expected that an additional 16 to 17 million more will be added to the tally.", "The present invention describes a rollover detection device effective for providing rollover safety to all vehicles having an electric fuel pump.", "Any feature or combination of features described herein are included within the scope of the present invention provided that the features included in any such combination are not mutually inconsistent as will be apparent from the context, this specification, and the knowledge of one of ordinary skill in the art.", "Additional advantages and aspects of the present invention are apparent in the following detailed description and claims.", "SUMMARY OF THE INVENTION The invention comprises a rollover safety device that automatically shuts off both the engine and electric fuel pump the instant a vehicle rolls or flips over a critical angle in any direction.", "The angles used to determine excessive tilt, or inclination, tend to vary by vehicle application.", "For instance, box shaped vehicles typically tip on their sides but rarely continue to roll over.", "The safety device can be configured to trigger at a desired angle of inclination depending on the vehicle type.", "The safety device is designed to be resectable with manufacturer support after such an accident.", "Once set due to a rollover, the safety device remains set, independent of power, until reset by a trained technician.", "By shutting off power to the fuel pump and starter, and shutting off the engine, the invention can reduce fires and explosions resulting from severe rollover accidents.", "In addition to saving lives, by reducing the hazards of rollover accidents, liability claims from rollover accidents can be reduced.", "The invention is relatively simple and cost-effective to construct, and is advantageous by not requiring power to keep the engine and fuel pump inoperative.", "According to one embodiment, the subject disclosure features a vehicle safety rollover device that, upon detection of a vehicle rollover, automatically shuts-off power to an ignition system of said vehicle and shuts down the electrical system and fuel pump of the vehicle.", "In some embodiments, the safety device comprises a power input, a ground input, a first latching relay switch, and a second latching relay switch.", "The ground input may be operatively connected to a vehicle common ground.", "In other embodiments, the first and second latching relay switches each comprise: an input, a first output position, a second output position, a set pin, and a reset pin, which is also connected to the ground input.", "The first output position is the initial position of each latching relay switch.", "When power is supplied to the set pin, the respective latching relay switch switches to the second output position.", "In further embodiments, the safety device additionally comprises an ignition start input, an ignition start output, and an electrical shut-off signal.", "The ignition start input may be operatively connected to the input of the first latching relay switch, while the ignition start output may be operatively connected to the first output position of the first latching relay switch.", "Further, the electrical shut-off signal may be operatively connected to the second output position of the second latching relay switch, where the input of the second latching relay switch may be operatively connected to the power input.", "In additional embodiments, the safety device employs a circular arc level, herein referred to as a CAL sensor, to detect an inclination of the vehicle.", "In some embodiments, the CAL sensor comprises an arcuate tube partially filled with a liquid.", "An air bubble is disposed in the arcuate tube such that the liquid and the air bubble fill the arcuate tube.", "In an embodiment, the air bubble rests at an apex of the arcuate tube when an inclination of the CAL sensor is zero.", "In other embodiments, the CAL sensor also comprises a first and second light emitting element each disposed on the exterior of the arcuate tube.", "In other embodiments, the first light emitting element is disposed at a first location about 75°-90° from the apex of the arcuate tube and emits a first optical signal.", "The second light emitting element is disposed at a second location about 270°-285° from the apex of the arcuate tube and emits a second optical signal.", "In supplementary embodiments, the CAL sensor may further comprise a first and second photodetector each disposed on the exterior of the arcuate tube.", "The first photodetector is disposed at a third location about 75°-90° from the apex of the arcuate tube, where the third location is opposite the first location such that the arcuate tube is disposed between the first light emitting element and the first photodetector.", "The first photodetector is positioned to detect the first optical signal when the air bubble is positioned between them.", "Additionally, the second photodetector is disposed at a fourth location about 270°-285° from the apex of the arcuate tube, where the fourth location is opposite the second location such that the arcuate tube is disposed between the second light emitting element and the second photodetector.", "The second photodetector is positioned to detect the second optical signal when the air bubble is positioned between them.", "Non-limiting examples of light emitting elements are light emitting diodes (LEDS).", "The liquid disposed in the arcuate tube is selected to prohibit detection of the first and second optical signals by the first and second photodetectors, respectively.", "For example, the liquid may be black to absorb all visible light signals emitted by the light emitting elements.", "As another example, the liquid may be green or yellow to block a red light signal.", "As can be understood by one of ordinary skill in the art, many such combinations exist.", "In supplementary embodiments, a conductive pin, a transistor, and a normally open switch additionally comprise the safety device.", "The conductive pin may be operatively connected to the battery power.", "The transistor may comprise a base pin, a collector pin, and an emitter pin.", "In an embodiment, the collector pin is connected to the alternator power while the emitter pin is connected to the first and second latching relay switches.", "In another embodiment, the base pin is connected to the conductive pin via the switch.", "The switch is operatively coupled to the first and second photodetector such that a first signal sent from the first photodetector (209) or a second signal sent from the second photodetector activates the switch to close.", "Consistent with previous embodiments, the CAL sensor is fixed to the body of the vehicle.", "When the CAL sensor is in an upright position relative to gravity, the air bubble rests at an initial position at the apex of the arcuate tube and the liquid is blocking detection of the first optical signal and the second optical signal.", "At an inclination of the CAL sensor within a first threshold window, centered at about 75°-90° from the apex of the arcuate tube, the air bubble travels from the initial position to rest between the first photodetector and the first light emitting element, thus activating the CAL sensor by permitting detection of the first optical signal.", "Upon detection of the first optical signal, the first photodetector transmits a first signal that activates the switch to close.", "In this way, a circuit is formed to allow current to flow through the conductive pin to the base pin, opens an electrical path from the battery power to each set pin.", "Additionally, at an inclination of the CAL sensor within a second threshold window, centered at about 270°-285° from the apex of the arcuate tube, the air bubble travels from the initial position to rest between the second photodetector and second light emitting element, thus activating the CAL sensor by permitting detection of the second optical signal.", "Upon detection of the second optical signal, the second photodetector transmits a second signal that activates the switch to close.", "In this way, a closed circuit is formed to allow current to flow through the conductive pin to the base pin, which opens an electrical path from the battery power to each set pin.", "At an application of the battery power to each set pin, the first and second latching relay switches switch from the first output position to the second output position, thus disconnecting power to the ignition starter.", "Moreover, power then flows to the electrical shutoff signal, via the second latching relay switch, thereby causing the electrical system of the vehicle to shut down.", "One of the unique and inventive technical features of the present invention is the implementation of a circular arc level sensor to detect vehicle rollover.", "Without wishing to limit the invention to any theory or mechanism, it is believed that the CAL sensor advantageously provides for an improved detection as a result of its lack of mass affected by centripetal or impact forces.", "Moreover, the CAL sensor employed in the present invention yields the most cost effective solution for sensing rollover.", "Since a single air bubble works in both directions simultaneously, only one CAL sensor is required for roll, and one for flip, if flip is necessary.", "The CAL sensor minimizes the potential of false triggering, provided that adequate debounce delay is created.", "Furthermore, the CAL sensor is self-resetting.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 shows a relay control schematic of an embodiment of the present invention comprising four relay switches.", "FIG.", "2 shows a diagrammatic representation of a circular arc level (CAL) used as a sensor in the present invention.", "FIG.", "3 shows a simplified relay control schematic an embodiment of the present invention comprising three relay switches.", "FIG.", "4 shows a bird's eye view of a vehicle roll-over.", "FIG.", "5 shows an exploded view of the mechanical implementation of an embodiment of the present invention.", "FIG.", "6 shows a magnified view of the CAL sensor having light emitters and light detectors mounted to an exterior of the CAL sensor.", "FIG.", "7 shows a top view of the CAL sensor.", "FIG.", "8 shows a cross-sectional view of the CAL sensor.", "FIG.", "9 shows an example embodiment of an elliptical sensor.", "FIG.", "10A-10B shows example embodiments of photo optic schematics that drive the photo optic components of the present invention.", "DESCRIPTION OF PREFERRED EMBODIMENTS Following is a list of elements corresponding to a particular element referred to herein: 101 third latching relay switch 102 fourth latching relay switch 103 first latching relay switch 104 alternator power 105 ground input 108 battery power 110 first and second ignition switch motor-on inputs 111 ignition start input 112 electrical shut-off signal 113 first ignition switch motor-on output 114 second ignition switch motor-on output 115 ignition start output 117 second latching relay switch 119-127 DIP switch positions 133 transistor 200 circular arc level sensor 201 arcuate tube 203 air bubble 205 first light emitting element 207 second light emitting element 209 first photodetector 211 second photodetector 502 screws 504 flange lid 506 photodetectors 508 light emitting elements 510 CAL sensor 512 photo optic circuit board 514 relay control board, circuit board 516 fuel pump control relay 517 Ignition control relays 518 wires 520 insulator 522 housing 602 first light emitting element 604 first photo detector 606 second light emitting element 608 second photo detector 610 leads 902 arc level tube 904 clear material 906 CAL end points 1006 dual comparator 1007 single comparator 1008 Logical OR Gate Referring to FIGS.", "1-10, the present invention is a vehicle rollover safety device comprising a custom sensor and circuit to detect vehicle rollover where, upon detection, the safety device shuts off power to the fuel pump, starter, and engine.", "In some embodiments, the safety device comprises a power input, a ground input (105), a first latching relay switch (103), and a second latching relay switch.", "The ground input (105) is operatively connected to a vehicle common ground.", "In other embodiments, the first (103) and second (117) latching relay switches each comprise: an input, a first output position, a second output position, a set pin, and a reset pin, which is also connected to the ground input (105).", "The first output position is the initial position of each latching relay switch.", "When power is supplied to the set pin, the respective latching relay switch switches to the second output position.", "In further embodiments, the safety device additionally comprises an ignition start input (111), an ignition start output (115), and an electrical shut-off signal (112).", "The ignition start input (111) may be operatively connected to the input of the first latching relay switch (103), while the ignition start output (115) may be operatively connected to the first output position of the first latching relay switch (103).", "Further, the electrical shut-off signal (112) may be operatively connected to the second output position of the second latching relay switch (117), where the input of the second latching relay switch (117) may be operatively connected to the power input.", "In additional embodiments, the safety device employs a circular arc level (200), herein referred to as a CAL sensor, to detect an inclination of the vehicle.", "In other embodiments, the CAL sensor comprises an arcuate tube (201) partially filled with a liquid.", "An air bubble (203) is disposed in the arcuate tube (201) such that the liquid and the air bubble (203) fill the arcuate tube (201).", "In an embodiment, the air bubble (203) rests at an apex of the arcuate tube (201) when an inclination of the CAL sensor (200) is zero.", "In alternate embodiments, the safety device employs an elliptical arc sensor, an embodiment of which is illustrated in FIG, 9.Turning now to FIG.", "9, the elliptical arc sensor (900) having an elliptical tube (902) is shown.", "In one non-limiting example, the tube (902) may include ends (906) that have a rectangular shape.", "The inside of the elliptical tube (902) is partially filled with a liquid/material (904).", "Returning to FIG.", "2, in some embodiments, the CAL sensor (200) also comprises a first (205) and second (207) light emitting element each disposed on the exterior of the arcuate tube (201).", "In other embodiments, the first light emitting element (205) is disposed at a first location about 75°-90° from the apex of the arcuate tube (201) and emits a first optical signal.", "The second light emitting element (207) is disposed at a second location about 270°-285° from the apex of the arcuate tube (201) and emits a second optical signal.", "In supplementary embodiments, the CAL sensor (200) may further comprise a first (209) and second (211) photodetector each disposed on the exterior of the arcuate tube (201).", "The first photodetector (209) is disposed at a third location about 75°-90° from the apex of the arcuate tube (201), where the third location is opposite the first location such that the arcuate tube (201) is disposed between the first light emitting element (205) and the first photodetector (209).", "The first photodetector (209) is positioned to detect the first optical signal when the air bubble (203) disposed in the arcuate tube (201) is positioned between them, as the arcuate tube (201) is transparent (or substantially transparent) at least between the first photodetector (209) and the first light emitting element (205).", "Additionally, the second photodetector (211) is disposed at a fourth location about 270°-285° from the apex of the arcuate tube (201), where the fourth location is opposite the second location such that the arcuate tube (201) is disposed between the second light emitting element (207) and the second photodetector (211).", "In preferred embodiments, the second photodetector (211) is positioned to detect the second optical signal when the air bubble (203) disposed within the arcuate tube (201) is positioned between them, as the arcuate tube (201) is transparent (or substantially transparent) at least between the second photodetector (211) and the second light emitting element (207).", "In one non-limiting example embodiment, the first light emitting element (205) is disposed at the first location about 80° from the apex of the arcuate tube (201) and the first photodetector (209) is positioned opposite the first emitting element (205), at 80° from the apex of the arcuate tube (201).", "In such an example, the second light emitting element (207) is disposed at the second location 280° from the apex of the arcuate tube (201) and the second photodetector (211) is positioned opposite the second light emitting element (207), at 280° from the apex of the arcuate tube (201).", "As such, the positions of the first light emitting element and the first photodetector may be interchanged without deviating from the scope of the invention.", "Likewise, the positions of the second light emitting element and the second photodetector may be interchanged without deviating from the scope of the invention.", "Non-limiting examples of light emitting elements are light emitting diodes (“LEDs”).", "The liquid disposed in the arcuate tube (201) is selected to prohibit detection of the first and second optical signals by the first (209) and second (211) photodetectors, respectively.", "For example, the liquid may be black to absorb all visible light signals emitted by the light emitting elements.", "As another example, the liquid may be green or yellow to block a red light signal.", "As can be understood by one of ordinary skill in the art, many such combinations exist.", "In supplementary embodiments, a conductive pin, a transistor (133), and a normally open switch additionally comprise the safety device.", "The conductive pin may be operatively connected to the battery power.", "The transistor (133) may comprise a base pin, a collector pin, and an emitter pin.", "In an embodiment, the collector pin is connected to the alternator power (104) while the emitter pin is connected to all four latching relay switches (103), (117), (102), and (101).", "In another embodiment, the base pin is connected to the conductive pin via the switch.", "The switch is operatively coupled to the first and second photodetector (211) such that a first signal sent from the first photodetector (209) or a second signal sent from the second photodetector (211) activates the switch to close.", "Consistent with previous embodiments, the CAL sensor (200) is fixed to the body of the vehicle.", "When the CAL sensor (200) is in an upright position relative to gravity, the air bubble (203) rests at an initial position at the apex of the arcuate tube (201) and the liquid is blocking detection of the first optical signal and the second optical signal.", "In one example embodiment, at an inclination of the CAL sensor (200) within a first threshold window, centered at about 75°-90° from the apex of the arcuate tube (201), the air bubble (203) travels from the initial position to rest between the first photodetector (209) and the first light emitting element (205) thus activating the CAL sensor by permitting detection of the first optical signal.", "Upon detection of the first optical signal, the first photodetector (209) transmits a first signal that activates the switch to close.", "In this way, a closed circuit is formed to allow current to flow through the conductive pin to the base pin, which opens an electrical path from the battery power to each set pin.", "Additionally, at an inclination of the CAL sensor (200) within a second threshold window, centered at about 270°-285° from the apex of the arcuate tube (201), for example, the air bubble (203) travels from the initial position to rest between the second photodetector (211) and second light emitting element (207) thus activating the CAL sensor by permitting detection of the second optical signal.", "Upon detection of the second optical signal, the second photodetector (211) transmits a second signal that activates the switch to close.", "In this way, a closed circuit is formed to allow current to flow through the conductive pin to the base pin, which opens an electrical path from the battery power to each set pin.", "At an application of power (e.g.", "battery power) to each set pin, the first (103) and second (117) latching relay switches switch from the first output position to the second output position, thus disconnecting power to the ignition starter.", "Moreover, power then flows to the electrical shutoff signal (112), via the second latching relay switch (117), notifying need for the electrical system of the vehicle to shut down.", "In an alternate embodiment, the safety device further comprises a third latching switch (101) and a fourth latching relay switch (102) each comprising: an input, a first output position, a second output position, a set pin, and a reset pin, which is also connected to the ground input (105).", "The first output position is the initial position of each latching relay switch.", "When power is supplied to the set pin, the respective latching relay switch switches to the second output position.", "In some embodiments, a first ignition switch motor-on input (110) is operatively connected to the input of the third latching relay switch (101), and a second ignition switch motor-on input (110) is operatively connected to the input of the fourth latching relay switch (102).", "Further, a first ignition switch motor-on output (113) may be operatively connected to the first output of the third latching relay switch (101), and a second ignition switch motor-on output (114) may be operatively connected to the first output of the fourth latching relay switch (102).", "Initially, the alternator power (104) flows through the third (101) and fourth (102) latching relay switch to the first (110) and the second (110) ignition switch motor-on input.", "When the CAL sensor (200) is activated, power flows from the power input to the set pins of the first (103), the second (117), the third (101), and the fourth (102) latching relay switches, causing each relay switch to switch from the first output position to the second output position.", "In this way, power to the first ignition switch motor-on input (110), the second ignition switch motor-on input (110), and the ignition starter is disconnected.", "Moreover, power flows to the electrical shutoff signal (112), thereby causing: notification for the electrical system of the vehicle to shut down, a notifying of an overseeing computer, and/or summoning of an emergency response.", "In an alternative embodiment, ignition start leads are connected to fuel pump power such that the fuel pump is shut off when the safety device is triggered.", "In some embodiments, the safety device may be mounted on a plane parallel to the vehicle firewall in order to monitor vehicle roll and/or on a plane perpendicular to the firewall to monitor vehicle flip.", "In other embodiments, the safety device may be placed within the steering column, behind the break pedal or clutch on the inside of the engine firewall.", "The CAL sensor may include a plurality of LEDs and photodetectors to detect vehicle rollover based on the change in bank angle with respect to time.", "By computing the time taken for three consecutively increasing angle photodetections, a roll acceleration can be calculated.", "If the predicted roll acceleration exceeds the effects of gravity to prevent the roll, the vehicle will rollover.", "In further embodiments, the safety device may comprise a dual in-line package (DIP) switch having a plurality of DIP switch positions (119-127).", "Each latching relay switch has two reset pins.", "In one aspect, connecting the first reset pin to the ground input causes the latching relay switch to switch to the second output position when power is applied to the set pin.", "In another aspect, connecting the second reset pin causes the relay switch to switch to the first output position when power is applied to the set pin.", "The DIP switch positions are connected to the two reset pins of the latching relay switches, and the final position of the DIP switch (119) bypasses the sensor, permitting a sensor trigger to be simulated during pre-installation testing.", "The DIP switches are nominally set such that the ground input is connected to the first reset pin and disconnected from the second reset pin.", "To reset the safety device, the DIP switch positions are reset so that the ground input is connected to the second reset pin of each relay switch.", "When the final DIP switch position is flipped, power is supplied to the latching relay switches, which causes them to switch to the original first output position.", "This causes the safety device to reset and the DIP switch positions to be reset to their original positions.", "As a result, the DIP switch permits all logic in the safety device to be tested.", "Three Relay Embodiment Referring now to FIG.", "3, an alternate configuration of the vehicle rollover safety device disclosed herein.", "Said configuration is one embodiment for shutting off the ignition start and fuel pump using the CAL.", "Further, the alternate configuration eliminates the need for the relay connecting/disconnecting the electrical line to the starter of the vehicle.", "In FIG.", "3, the alternate configuration of the vehicle safety device includes three relay latching switches (101), (102), and (103) of FIG.", "1, and does not include the second relay latching switch (117) of FIG.", "4.FIGS.", "5-8 illustrate a mechanical implementation of an embodiment of the present invention and FIGS.", "10A and 108 illustrate example additional circuitries of the present invention.", "A sensor (510), such as the CAL sensor 200 of FIG.", "2 and/or the elliptical arc sensor (900) of FIG.", "9, is mounted on a printed circuit board (PCB) (512).", "The PCB (512) sits atop circuit board (514) which includes a relay circuitry or ignition control relays (517) and a photo optic circuitry (516).", "The photo optic circuitry of FIG.", "10 A or FIG.", "10 B may be one non-limiting example of the relay circuitry described with reference to FIGS.", "1 and 3.More specifically, the Ignition control relays (617) detects vehicle rollover where, upon detection, the relay circuitry within the safety device shuts off power to the fuel pump, starter, and engine.", "The photo optic printed circuit board (PCB) that drives the photo optic components of the sensor (510) is described further below with reference to FIGS.", "10A-B.", "Wires (518) couple the components of the photo optic parts to the PCB 512 to external components.", "As described previously with reference to FIG.", "5, light emitting elements (508) and photodetectors (506) interface through an exterior of the arcuate tube sensor.", "A magnified view (600) of FIG.", "6 shows a first light emitting element (602) shining through an end point (or a first end) of the sensor (510).", "A first photodetector (604) is mounted diametrically opposite to the first light emitting element (602) Likewise, a second light emitting element (606) shines through the other end point (or a second end) of the sensor (510), and a second photodetector (608) is mounted diametrically opposite to the second light emitting element (606), on the other end point of the sensor (510).", "Leads (610) of each of the first light emitting element, second light emitting element, first photodetector, and the second photodetector solder into underlying PCB (512) and electrically couple the light emitting elements and the detectors to the underlying photo optic circuitry (516).", "Turning now to FIGS.", "10 A and 10 B, schematic diagrams of example photo optic circuitries (1000) and (1050) that drive the photo optic components of the sensor (510) are shown.", "Specifically, the photo optic circuitries drive the light emitting elements and the photo detectors coupled to the sensor (510).", "Photo optic circuit (1000) includes a single dual-comparator 1006, resistors R1-R5, transistors Q1-Q2, photo diodes Q2-Q3.In another example embodiment, photo optic circuit 1050 includes two single comparators (1007), instead of a single dual-comparator (1006).", "As an example, the photo optic circuits (1000) and (1050) read the presence of antifreeze based on the voltage applied to the IR emitter.", "The voltage output of the photo transistor varies in an inverse square relationship to the IR emitter's input voltage.", "Surround clamps may be used to accurately position flanged cylindrical electronic parts, such as, but not limited to: LEDs, IR emitters, Photo diodes and Photo transistors.", "When designing surround clamps with materials that flex, but return to their original shape when unused, it is best to size the clamp's inner diameter and top opening one measurable unit smaller than the minimum tolerance range of part's outer diameter.", "As 3D printer technology futures, it is more economical to manufacture and test these clamps for wall thickness acceptability than running through extensive material stress analysis calculations, In general, the thicker the clamp wall, the more force is required to insert and remove the part from the clamp.", "These clamps may include a flange slot or ring to insure the part remains positioned precisely within the clamp.", "The sensor (510) along with the relay circuitry (516) and the photo optic circuitry (516) are mounted inside a box (522) and sealed using flange lid (504) and insulator (520).", "The flange lid (504) is mounted to the box (522) with the aid of screws (502).", "The entire assembly with the sensor, light-emitting elements, photo detectors and the circuitries mounted inside the box may be referred to as a vehicle roll-over detection unit.", "A top view of the unit is shown in FIG.", "7, and a cross-sectional view of the unit is shown in FIG.", "8.Additional Features of the Present Device In some example embodiments, the unit may automatically reset following roll over upon receiving appropriate protocol from a hardwired cell phone interface.", "Additionally, or alternatively, the unit may include redundant sensors detecting the roll over condition, the CAL and an accelerometer.", "These sensors may be ANDED together for rollover realization.", "Additionally, or alternatively, the unit may deter auto theft by detecting a manual jump start attempt and report the attempt to both driver/police.", "Herein, two cell phones may be used, one permanently associated with the car, and another maintained by the driver.", "Additionally, or alternatively, the unit may be operated in a security mode wherein the unit may require the thief to hard wire repair the cut in the fuel pump line and jump start by passing the ignition system, all while the microprocessor (uP) may be detecting the theft attempt and reporting its progress to the driver/police.", "Additionally, or alternatively, the unit may stop an engine from being started if the temperature is below manufacturer's (or driver's) specified tolerance.", "Additionally, or alternatively, the unit may cause an “out of gas condition” if the engine temperature exceeds a learned maximum, thus reducing, engine damage upon overheating.", "Additionally, or alternatively, each unit may maintain its own historical log which may be examined and used to further optimize the unit's future operation.", "Additionally, or alternatively, the unit may have a direct USB cell phone interface that may reduce the possibility of RF emission that could be captured and replayed for illegal car starting.", "All communication across this interface may be time/date stamp encrypted, so that signal tapping and replay over hard wire may not be possible.", "Additionally, or alternatively, the unit may issue automated assistance summons in the event of excessive tilt or attempted theft.", "Additionally, or alternatively, the unit may monitor its own temperature and log it for failure analysis.", "Additionally, or alternatively, the unit may monitor status of all relays at all times.", "Additionally, or alternatively, the unit may monitor status of its incoming powered connections and notify driver if any of these connections become disconnected from power (once installed successfully).", "In some example embodiments, the unit may be operated in one of the modes of operation listed below: Mode 1—Normal operating mode—Ignition relays and fuel pump relays closed Mode 2—Security Mode—Ignition relays open and fuel pump relay closed Mode 3—Ultimate Security Mode—Ignition Relays and fuel pump relay open Mode 4—Over heated engine Mode—Ignition Relays closed, fuel pump relay open The following description details how the aforementioned features may be accomplished.", "Input feed from microprocessor (alternately, “uP”) to Q1 transistor for startup and reset is continuously output from the uP to the Asynchronous Communication interface Adaptor (“ACIA”) as Bit 6, and is zero normally (when neither startup or reset are occurring), Its output will swing between 0 to 3.3 VDC.", "The 3.3 VDC output should be sufficient to trigger Q6.There exist two initialization logic flows.", "The first is used for product installation, while the second is d whenever power is lost then restored.", "Product installation requires the use of a steering wheel mounted cell phone and custom application (“app”).", "The product first requests the installer's cell phone number.", "Using a cellular phone transceiver chip within the device, the steering wheel cell phone and device establish bi-directional encrypted communication.", "Text messages from the device will be both audibly sounded as well as logged for communication trail purposes.", "Each wiring hook up required will be software checked for accuracy prior to moving on.", "First hook up power and ground.", "Through software, confirm power and ground were connected successfully.", "Once the ignition switch relay interface has been checked, the relays will remain open to confirm the car will not start.", "Then through software, close the relays and confirm the car starts normally.", "If at any time the relays refuse to change to open or closed state, inform the operator the unit is faulty.", "If the unit is faulty, return the unit then restart installation with a new unit.", "Next, assuming the unit passed the last test, hook up the fuel pump leads, power on lead first.", "Once the leads are software examined accurate, close the fuel pump relay and start the car.", "Through software, open the fuel pump relay.", "If the operator experienced an out of gas condition causing the engine to eventually stall, close the relay.", "Then insure the car starts normally.", "Next, hook-up the starter line tap to the unit, and confirm through software no power is present.", "Start the engine, while the starter is engaged, power should be briefly present on the starter line tap.", "If power was present momentarily, assume the starter line has been correctly connected.", "Next, connect the temperature gage loop tap to the device input.", "If it lies between 1 and 0 assume it is connected correctly.", "This completes the product installation.", "Text the installer, informing him job well done, and log installation time/date to flash RAM.", "Configure relays to security mode and bring up driver login app.", "The CAL sensor input line is fed into uP as the analog to digital convert (“ADC”) Line 11, DV/DT (The increase in voltage with respect to time is continuously monitored independent of temperature).", "Should this increase by 25% or more within 0.5 seconds, the bubble can be assumed to have reached a CAL end point.", "The sense a critical accident has occurred is 50%.", "The accelerometer is also being simultaneously monitored for 85 degree shifts in vehicle orientation in the roll and flip directions.", "When the first 85 degree change in orientation is detected, the sense a critical accident has occurred is 50%.", "Once the sense of a critical accident has occurred reaches 100% (i.e., both the CAL and accelerometer agree), universal asynchronous receiver transmitter (“UART”)=0, Bit 6=1 is output.", "Timer 1 begins its count down of 20 ms. Once Timer is time elapsed is just enough to trip the magnetic latching relays (approx.", "20 ms), UART 0, Bit 6=0 is output and the fact that sensor input has triggered the relays is recorded in flash memory to prevent all further sensing of initial accident criticality.", "Initial accident criticality is reported on every means of bus and cellular output available.", "Since there are now theft and critical accident output possibilities, a single wire output cannot be used.", "uP controlled startup uses UART 0, Bits 0-5 as outputs to the bases of an 8-gate transistor array, replacing the DIP switches.", "UART 0, Bit 6 is used to pulse on/off transistor Q6 as needed to perform startup/reset operations for the ignition system relays.", "UART 0, Bit 7 is used to pulse on/off transistor Q7 as needed to perform startup/reset operations for the fuel pump relay.", "Reset is performed by removing then re-applying power to the housings reed/black leads (provided the sensor input has triggered the relays, once reset is complete this fact is erased).", "Simply disconnecting the vehicles +12 VDC battery will cause the device to reset.", "The Accelerometer is placed on the relay PCB and is interfaced directly into the uP's ADC1, ADC2 and ADC3.Utilize basic Accelerometer to uP schematic and canned software interface routines.", "The photo optics sensors, utilizing photo diodes, and cherry red emitters, are ORed into one line and fed into an additional ADC through a +12 VDC.", "GND, (plus other conductors) interface ribbon cable between PCBs.", "I2C interface in both software and hardware.", "Serial bus interface in both software and hardware.", "Must record both high and low temperatures at equal priority, retaining these values in flash memory.", "Multiple processors.", "Utilize different resistor values to uniquely divide the voltage going into Multiplexer inputs 14 and 15 feeding ADC input.", "This way each processor will assume mastership in the order of greatest resistance used.", "The greater the resistance, the lower reading on the ADC.", "Using the ADC value as a countdown timer, the uP with the lowest timer countdown will boot first.", "Should communication cease from the primary for any reason, the next uP having the lowest ADC resistance will assume mastership.", "This way one can have as many potential master CPUs as necessary.", "By default, light an instrument panel warning light.", "Use the watch dog timer to insure the processor is operational.", "Once the processor becomes operational, extinguish the warning light.", "Should the processor ever cease functioning while the engine is running, re-light the warning light.", "Turn off the instrument panel warning light once the processor begins running normally.", "Power Line Monitored.", "Feed the +12VDC power line into ADC12.Use the Parallel Port 0, Bit 5 to control a transistor that switches on board battery power to the uP, multiplexer and cellular transceiver.", "Tap off the temperature gage loop, feeding the tap into Multiplexer Line 0 into ADC.", "Use the device to monitor the actual engine temperature and learn when it is outside temperature thresholds to operate.", "If the engine is too cold or too hot to operate, based on menu tolerances set by the vehicle manufacturer, vehicle owner or owner's mechanic, a battery disconnect/connect will be required to enable the device to avoid monitoring current engine temperature for one restart.", "On subsequent restarts, the device will return to using its saved preset temperature starting values for tolerance range to enable engine start.", "Voltage division must be used on the input of the ADC to insure +3.3 VDC max.", "Also, the output of ADC must be connected to ground through high impedance so the signal transmitting the temperature to the dash gage will not be effected by the tap as it is not a good idea to shut off engine on the pilot whenever it gets too hot, but just shutting off the fuel pump when it's too hot would simulate an out of gas situation.", "Preventing the engine from starting when it is too cold ensures the warranty conditions are up kept safely.", "Use the device as a security ally.", "When the key turns off a normally running engine, open the ignition circuit and close the fuel pump circuit.", "When the ignition power is manually shorted, by a thief, to jump the engine, open fuel pump circuit, log and notify of theft attempt to police and driver, initiate a one-day operational delay before the vehicle can be placed back in service to the owner.", "This is done because the starter line went high while the ignition relay was open.", "Once the one-day operational delay has lapsed, reconfigure the device back to normal engine off condition.", "In the event that no theft attempt has occurred since turning the engine off, one way to permit engine start is to request at shut off time, the expected time the vehicle needs to remain off, prior to being restarted.", "This random time, known only to the operator and car's uP, could be used by the uP to auto configure the ignition relays to closed, precisely when the appropriate time has elapsed.", "With the ignition relays closed and the fuel pump relay closed, the engine may be restarted.", "The only problem with this solution is that one can very rarely predict precisely how long they require the engine to remain off.", "This is due to unpredictable appointment length times, shopping times, etc.", "What is needed is an authorization signal which will positively identify the driver's presence to the car, while providing the maximum amount of safety during the vehicle restarting circumstance.", "The perfect authorization signal with today's technology is the brake light loop.", "When the driver steps on the brake to start the car, the software configures the ignition relays closed, enabling the car to start normally.", "Odds are the thief jump starting the car will not press on the brake during the theft.", "If the brake loop authorization signal standard be figured out by thieves, each driver may customize this signal for his own security; using for example, the right turn signal lamp loop instead.", "Ultimate security mode.", "Tap the starter line, convert input to 3.3 VDC range and feed into a parallel port input.", "Should the input go high after the car is already started for approximately 5 seconds, apply the security feature.", "If the operator attempts to restart the car once it is started, disable the engine from operating until the battery is disconnected then reconnected.", "This feature should only be used in the event of a hostile takeover attempt or whenever you wish to safely leave the vehicle parked for a long period of time.", "In ultimate security mode, both the ignition switch relays and the fuel pump relay remain closed.", "The reason for engine disability must be logged, so that it may be referenced to restart properly.", "Once restarted, the reason for engine disability is cleared.", "If the car is immediately restarted you get the traditional starter grinding sound.", "Device engine disable forces a thief to both hot wire the ignition system and patch the break in the fuel pump line, prior to vehicle take over, all while the situation is being monitored by the uP.", "Utilize the software to maintain logs from each device placed in a test environment.", "After the device(s) are returned, their logs may be analyzed to determine whether they performed properly.", "Create a universal cradle to position a cell phone in the center of a steering wheel.", "The cradle will have a hook ad loop fastening flap at the top to prevent the phone from falling out during steering wheel rotation.", "An app to inquire a drivers PIN code or SSN will be needed to identify the driver to the device prior to starting the vehicle.", "The ID will not be stored in the phone, but may reside permanently in uP memory (encrypted).", "The ID will not change with time.", "The cradle can attach with two nylon cable ties on the backside of the steering wheel spokes.", "A cellular RF transceiver located in the device will be used to transmit/receive messages from the steering wheel cell phone.", "The device will transmit all it needs by using a +12 VDC auto battery.", "This should provide the device with more transmission power than the typical cellular phone.", "The device cell phone transceiver will only be used during product installation, owner license update and report of most severe situations.", "All transceiver communication will be time/date stamp encrypted to avoid RF capture and playback.", "Tap off automatic door lock loop to determine when the vehicle first starts to travel.", "Technically an auto theft cannot be recognized until the vehicle is physically moved from one place to another without the drivers consent.", "When the door lock tap goes high, place the device in Mode 3, shutting off the fuel supply.", "Using a timer, turn on the fuel pump when you are sure the vehicle has stalled.", "When the timer elapses place the device in Mode 3.This way the thief cannot ohm out the fuel pump line to determine that the location of the break occurred within the device.", "Also, when the auto theft is detectable, cellular call 911 with location, license and owner information, then call the owner informing him not to approach the vehicle until informed its safe by police.", "The device may be protected to prevent criminals from removing the device, reconfiguring the wiring to original condition prior to device installation, then successfully jumping the car.", "The device will be designed to detect whenever someone tries to remove it while powered on, however, it cannot function fully to protect itself when power is cut off.", "All wire taps required will only need 24 gage wire wrap wire put to the device.", "The CAL will be held down and accurately positioned on the PCB using three 24-gage wire wrap wire tie downs.", "Circular Arc Level (“CAL”) Sensor Details The CAL sensor is a sensor that measures gravitational norm deviation while remaining impervious to the effects of acceleration, deceleration, impact and centripetal forces.", "It measures the angles an object is off from the vector of direct gravitational pull.", "More specifically, the CAL sensor is used to measure exact tilt, or inclination.", "In combination with a microprocessor, the change in inclination of an object with respect to time may be acquired.", "When used in perpendicularly oriented pairs, the CAL sensor may be used to measure both roll and flip of a vehicle.", "The CAL sensor offers a solid state solution to tilt detection since its only moving part is a frictionless bubble.", "The air bubble disposed within the CAL sensor may be sized to satisfy necessary requirements for measuring the angle(s) of inclination.", "Without wishing to limit the invention to any theory or mechanism, the liquid disposed within the CAL sensor does not fully encompass the air bubble.", "Typically, the air bubble spans the width of the CAL sensor such that two opposite sides of the bubble are in constant contact with the inside of the CAL sensor.", "Thus, when the air bubble is disposed between a photodetector and an LED, the optical path of the light beam emitted from the LED goes through the air bubble without encountering the liquid.", "The light beam should be perpendicular to the CAL sensor surface to minimize light loss in refraction off the material (of which the CAL sensor is composed) the light is passing through.", "The photodetector may then read the angle as the light beam passes through the bubble.", "The volume of the bubble used by the CAL is best calculated by the mechanical design tool used to scale design the CAL itself.", "The tool positions the photo optic parts directly across from one another tangent to the CAL.", "The bubble must extend from the center point of the IR emitter to the end point of the CAL frame.", "Upwards, the bubble should extend to the full transmission cone of the IR emitter as the cone strikes to the furthest CAL wall.", "Assuming the IR emitter emits a cone of light having a broadcast angle A, then the bubble must extend upwards from the center point of the cone, which is CAL width * sin (A/2).", "Knowing the volume of the bubble and the volume of the CAL, which the mechanical model calculates, the volume of the antifreeze needed is given by the difference: (CAL volume)—(Bubble Volume).", "Having this volume measured in CCs the CAL may be filled easily with antifreeze using a broad needle syringe.", "One concern with the CAL sensor is that vibration or pre-installation shaking may cause the air bubble within the CAL sensor to separate temporarily.", "However, as with a standard carpenter's level, which is filled with standard antifreeze, the air bubble instantly settles intact and usable after shaking.", "Depending on the application, an arc of a circle may be sufficient for the design of the CAL sensor.", "However, some applications may require an entire circle.", "In some cases, the CAL may be filled with black dyed antifreeze, enabling it to withstand an expansive range of temperatures.", "For improved accuracy, the CAL sensor may be video recorded and computer analyzed.", "Even upon exiting an effect of a gravitational field, measurements obtained by the CAL sensor reflect the last known gravitational field situation.", "Upon entry to a gravitational field of increasing strength, the CAL sensor adjusts to reflect the object's orientation relative to gravitational field's norm of gravitational pull.", "The CAL sensor is ideal for predicting and detecting vehicle rollover.", "To detect a roll over, it can be assumed that any vehicle whose center of mass rolls more than 90° will rollover on its side or possibly flip.", "The CAL sensor may be constructed to detect a roll of between 50 and 90° (selectable in increments of 10°) in either direction (50° to 90° or −50° to −90°) by adjusting the placement of the photodetectors and LEDs.", "In this way, an accident severe enough to be considered critical may be detected.", "FIG.", "1 shows a configuration of the safety device utilizing the CAL sensor.", "The safety device is placed in a housing, and the housing may be oriented parallel to the vehicle firewall to detect roll severity.", "A second, identical housing, having a second safety device disposed therein, may be oriented perpendicularly to detect vehicle flip severity.", "By wiring the safety devices in parallel, the first safety device to register tilt deviation outside critical limits will result in an initiation of accident prevention measures (e.g.", "disconnection of ignition starter, shut down of the electrical system, a summoning of an emergency response, etc.).", "A more advanced CAL sensor configuration may be constructed by adding a microprocessor, enough multiplexers to handle CAL sensor inputs, an analog to digital converter, and a digital output display.", "By reading light transmission through the air bubble and spacing photodetectors/LEDs such that a portion of the bubble can always be tracked, the CAL sensor can provide a continuous digital readout of the angular position of any object on which the CAL sensor is disposed.", "When employed with a microprocessor (alternately, “uP”), one embodiment of the device comprises the following microprocessor input/outputs: Serial communication line between uP and cell phone USB port (UART0, 19.2KB) Encrypted bi-directional protocol to obtain engine startability in secure state.", "Encrypted bi-directional protocol to summon towing assistance, police assistance, rescue assistance, fire department assistance, etc.", "Based on reason for changing engine's operational status.", "Encrypted bi-directional protocol to toggle on/off transmission of cars GPS location.", "Serial communication line between upper PCB and bottom PCB ACIA (UART0, 19.2KB).", "Serial line bits: Bits 0,1: output to lower PCB transistor array to configure open//closed position of ignition relay 1 Bits 2,3: output to lower PCB transistor array to configure open/closed position of ignition relay 2; Bits 4,5: output to lower PCB transistor ay to configure open/closed position of fuel pump relay; Bit 6: output to lower PCB Q1 transistor used to apply power for configuration of ignition relays: Bit 7: output to lower PCB Q2 transistor used to apply power for configuration of fuel pump relay.", "3) Vehicle temperature sensor inputs, to upper PCB, for line tap to ADC multiplexed line 0.4) Vehicle starter line inputs, to upper PCB, for tapped input to Multiplexed ADC line 1.5) Accelerometer line inputs, on upper PCB, to Multiplexed ADC lines 2, 3 and 4.6) Parallel Port 0, Bits 0-3.Used to address multiplexer for input to ADC.", "7) Interface cable between upper and lower PCBs of 9 Conductors: +12 VDC, GND and UART1 Xmit line, relay output leg status lines feeding as input to Multiplexer ADC lines 5, 6 and 7, and relay input leg status lines feeding as input to Multiplexer ADC lines 8, 9 and 10.Note—If all multiplexer inputs are 0-+12 VDC, a single voltage divider can be applied to the multiplexer output.", "8) Parallel Port 0, Bit 4.Used in combination with inverter, to turn on/off uP status dashboard lamp based on uP's watch dog timer.", "9) Auto battery input power line, for Multiplexer ADC line 12 Parallel Port 0, Bit 5.Status of auto power, 0=off, 1=+12 VDC.", "10) CAL line input, on upper PCB, for Multiplexer ADC line 11.11) Automatic door lock loop tap, on upper PCB, for Multiplexer ADC line 12.12) Authorization to start: Brake line loop, on upper PCB for Multiplexer ADC line 13.13) Multiple processor ADC feeds.", "Multiplexer input lines 14 and 15 are connected to unique resistive loads so that each microprocessor boots in order.", "14) Parallel Port 0, Bit 5.Used as output of a jump start condition detected, 0—No jump start detected, 1—Jump start detected.", "15) Parallel Port 0, Bit 6.Used to output condition of a critical accident.", "0—No critical accident occurrence, 1—Critical Accident has occurred (only resettable by disconnecting/connecting +12 VDC power).", "CAL Sensor Construction Possibilities Depending on cost effectiveness, a CAL sensor may be designed for the roll over sensor in several different ways.", "In all instances, the CAL sensor must fit within an existing housing.", "Without wishing to limit the invention to any theory or mechanism, the following are possible methods for constructing the CAL sensor.", "In some embodiments, the CAL may be constructed from flexible, clear tubing with end stoppers that either clamp or press fit.", "Removal and replacement of the end stopper allows for fill and fluid/bubble exchange.", "In some embodiments, the CAL sensor could be constructed from a clear glass arced tube sealed at both ends.", "The tube should have two holes drilled in it for air escape and fluid replacement.", "The tube should be rigid and placed on a raised floor to the mean height of the LED and photodetector.", "In some embodiments, the CAL sensor is perfect for a process control application for an automated syringed air/liquid sandwiched between two press fit plastic sheets with LED and photodetector housings formed in the plastic, especially once the optimal monitoring angle combination can be determined.", "p In some embodiments, the CAL sensor can be constructed from a leak proof press fit plastic arced tube having two holes on the top for liquid fill, then taped to prevent leakage.", "A universal plastic tray could be constructed to hold the arcuate tube, LEDs, and photodetectors in appropriate position.", "The LEDs and photodetectors may snap in place.", "Different tube arcs may be designed to expedite trigger time, with a center mark, so they could be taped into the tray approximately.", "This design could easily be upgraded as LED and photodetector size diminishes.", "This permits the arcuate tube and LEDs/photodetectors to be discarded and replaced easily.", "If the CAL must be constructed in parts and bonded together, the bonding agent should be of exactly the same material from which the CAL is constructed.", "When constructing a CAL using a 3D printer, the CAL is typically created from three parts: the CAL/tray (to hold the photo optics in position), a cover to provide closure to the CAL, and a fill stopper (to completely seal the CAL once it is filled with antifreeze).", "By UV light bonding these three parts together with material that is identical to the material used to create the parts, one can be assured the CAL will remain leak proof under all temperature ranges the material itself can withstand.", "Expansion and contraction will occur.", "However, by bonding with the same construction material, the joints will expand and contract in exactly the same way as all parts comprising the CAL.", "Preliminary testing shows constructing the CAL of Samos WaterShed XC 11122 poly resin is satisfactory directly off the printer.", "No additives are necessary to add to the antifreeze and the porosity of the material is low enough for the CAL to remain leak resistant for the expected life of a passenger vehicle.", "Lastly, although, means to improve the plastic parts (e.g., making them more transparent and less porous using an acetone spray prior to bonding) exists, it is not recommended in order to keep the manufacturing costs minimized.", "Potential Application of the Present Device: Auto-Theft Proof Design Objectives of the auto-theft proof design: discern between a normal engine start and a thief's jump start; in the event of a jump start, disable the vehicle the instant it moves; lock thieves inside for up to a day maximum; and means by which vehicle is disabled must be temporary, so that it cannot be traced and bypassed in the future.", "Additional Applications of the CAL Sensor Additional and non-limiting applications of the CAL sensor include the following: Vehicle curve banking and forward incline/decline; Artificial equilibrium; Aircraft glidescope and dive/climb; Ship pitch and yaw; Gravitational field descent landing optimizer; Gravitational field detector; Tilt measurement tool (relative to gravitational field norm for Building construction and Process control; Adjustable tilt control; Gravitational guidance technology for Cruise missiles (full circle CAL sensor) and Rockets; Photographic orientation; Valuable artifact movement sensor (flattened arc, narrow bubble, peak point, monitored bi-directionality); Museum curios; Weapons in storage; and movement of Fuel storage casks.", "As used herein, the term “about” refers to plus minus 10% of the referenced number.", "Various modifications of the invention, in addition to those described herein will be apparent to those skilled in the art from the foregoing description.", "Such modifications are also intended to fall within the scope of the appended claims.", "Each reference cited in the present application is incorporated herein by reference in its entirety.", "Although there has been shown and described the preferred embodiment of the present invention, it will be readily apparent to those skilled in the art that modifications may be made thereto which do not exceed the scope of the appended claims.", "Therefore, the scope of the inventor is only to be limited by the following claims.", "Reference numbers recited in the below claims are solely for ease of examination of this patent application, and are exemplary, and are not intended in any way to limit the scope of the claims to the particular features having the corresponding reference numbers in the drawings.", "In some embodiments, the figures presented in this patent application are drawn to scale, including the angles, ratios of dimensions, etc.", "In some embodiments, the figures are representative only and the claims are not limited by the dimensions of the figures.", "In some embodiments, descriptions of the inventions described herein using the phrase “comprising” includes embodiments that could be described as ‘consisting of’, and as such the written description requirement for claiming one or more embodiments of the present invention using the phrase “consisting of” is met." ] ]
Patent_15872829
[ [ "TUMBLE GYRO SURVEYOR", "A gimbal sensor platform positionable in a tool body includes an inner gimbal and an outer gimbal.", "The inner gimbal is rotatably coupled to the outer gimbal, and the outer gimbal is rotatably coupled to the tool body.", "The inner and outer gimbals may each be rotated by an angular positioning device.", "A gyro or other sensor may be coupled to the inner gimbal.", "The gyro or other sensor may be reoriented by rotating the outer gimbal, the inner gimbal, or both." ], [ "1.A gimbal sensor platform positionable in a tool body having a longitudinal axis, the gimbal sensor platform comprising: an outer gimbal, the outer gimbal rotatably coupled to the tool body; an outer angular positioning device coupled to the outer gimbal to rotate the outer gimbal relative to the tool body about an outer gimbal axis of rotation; an inner gimbal, the inner gimbal rotatably coupled to the outer gimbal; an inner angular positioning device coupled to the inner gimbal to rotate the inner gimbal relative to the outer gimbal about an inner gimbal axis of rotation; and a gyro coupled to the inner gimbal.", "2.The gimbal sensor platform of claim 1, wherein the outer gimbal axis of rotation is substantially parallel to the longitudinal axis of the tool body.", "3.", "(canceled) 4.The gimbal sensor platform of claim 1, wherein the inner gimbal axis of rotation is canted to the outer gimbal axis of rotation.", "5.The gimbal sensor platform of claim 4, wherein the inner gimbal axis of rotation is substantially perpendicular to the outer gimbal axis of rotation.", "6.The gimbal sensor platform of claim 5, further comprising an inner limit stop, the inner limit stop positioned to restrict rotation of the inner gimbal between a first cant angle and a second cant angle relative to the outer gimbal axis of rotation.", "7.The gimbal sensor platform of claim 6, wherein the first cant angle and second cant angle are in opposite directions of the outer gimbal axis of rotation.", "8.The gimbal sensor platform of claim 1, further comprising one or more accelerometers coupled to the inner gimbal.", "9.The gimbal sensor platform of claim 1, further comprising one or more magnetometers coupled to the inner gimbal.", "10.", "(canceled) 11.", "(canceled) 12.", "(canceled) 13.The gimbal sensor platform of claim 1, further comprising one or more accelerometers coupled to the tool body.", "14.The gimbal sensor platform of claim 1, further comprising one or more magnetometers coupled to the tool body.", "15.", "(canceled) 16.The gimbal sensor platform of claim 1, further comprising an outer angular position measuring device coupled between the outer gimbal and the tool body.", "17.The gimbal sensor platform of claim 1, further comprising an inner angular position measuring device coupled between the inner gimbal and the outer gimbal.", "18.The gimbal sensor platform of claim 1, wherein the gimbal sensor platform is coupled to a drill string or a wireline system.", "19.The gimbal sensor platform of claim 1, further comprising an outer limit stop, the outer limit stop positioned to restrict rotation of the outer gimbal relative to the tool body.", "20.A method comprising: providing a gimbal sensor platform positioned in a tool body, the gimbal sensor platform including: an outer gimbal, the outer gimbal rotatably coupled to the tool body; an outer angular positioning device coupled to the outer gimbal to rotate the outer gimbal relative to the tool body about an outer gimbal axis of rotation; an inner gimbal, the inner gimbal rotatably coupled to the outer gimbal; an inner angular positioning device coupled to the inner gimbal to rotate the inner gimbal relative to the outer gimbal about an inner gimbal axis of rotation; and a gyro coupled to the inner gimbal; taking a first measurement with the gyro with the outer gimbal in a first position relative to the tool body and the inner gimbal in a first position relative to the outer gimbal; rotating the inner gimbal to a second position relative to the outer gimbal; taking a second measurement with the gyro; rotating the outer gimbal to a second position relative to the tool body, the position of inner gimbal defining a third position; and taking a third measurement with the gyro.", "21.The method of claim 20, further comprising determining an azimuth or a gyro toolface of the tool body.", "22.The method of claim 20, further comprising determining the orientation of the gyro at each of the first, second, and third measurements relative to the tool body.", "23.The method of claim 21, further comprising: identifying gyro mass unbalance or error based at least in part on the first, second, and third measurements.", "24.The method of claim 21, wherein the gimbal sensor platform further comprises one or more accelerometers coupled to one or more of the inner gimbal, outer gimbal, or tool body, and the azimuth of the tool body is determined at least partially based on the readings of the accelerometers.", "25.The method of claim 21, wherein the gimbal sensor platform further comprises one or more magnetometers coupled to one or more of the inner gimbal, outer gimbal, or tool body, and the azimuth of the tool body is determined at least partially based on the readings of the magnetometers.", "26.The method of claim 21, wherein the gimbal sensor platform further comprises one or both of an inner angular position measuring device coupled between the inner gimbal and the outer gimbal or an outer angular position measuring device coupled between the outer gimbal and the tool body, and the azimuth of the tool body is determined at least partially based on the readings of any angular position measuring device.", "27.The method of claim 20, wherein the gimbal sensor platform further comprises one or more accelerometers coupled to one or both of the inner gimbal or outer gimbal, and the method further comprises: taking a first acceleration measurement with an accelerometer at the first, second, or third position; and determining an azimuth or inclination of the tool body.", "28.The method of claim 27, further comprising: taking a second acceleration measurement with the accelerometer at a different position of the first, second, or third positions; and identifying accelerometer error or bias based on the first and second acceleration measurements.", "29.The method of claim 20, wherein the gimbal sensor platform further comprises one or more magnetometers coupled to one or both of the inner gimbal or outer gimbal, and the method further comprises: taking a first magnetometer measurement with a magnetometer at the first position, second position, or third position; and determining an azimuth or inclination of the tool body.", "30.The method of claim 29, further comprising: taking a second magnetometer measurement with the magnetometer at a different position of the first position, second position, or third position; and identifying magnetometer error or bias based on the first and second magnetometer measurements.", "31.", "(canceled) 32.A method comprising: providing a gimbal sensor platform positioned in a tool body, the gimbal sensor platform including: an outer gimbal, the outer gimbal rotatably coupled to the tool body; an outer angular positioning device coupled to the outer gimbal to rotate the outer gimbal relative to the tool body about an outer gimbal axis of rotation; an inner gimbal, the inner gimbal rotatably coupled to the outer gimbal; an inner angular positioning device coupled to the inner gimbal to rotate the inner gimbal relative to the outer gimbal about an inner gimbal axis of rotation, the inner gimbal axis of rotation substantially orthogonal to the outer gimbal axis of rotation; an inner limit stop, the inner limit stop positioned to constrain the rotation of the inner gimbal, such that the inner gimbal contacts the limit stop when rotated to a first cant angle relative to the outer gimbal axis of rotation and when rotated to a second cant angle relative to the outer gimbal axis of rotation; and a gyro coupled to the inner gimbal; taking a first measurement with the gyro with the outer gimbal in a first position relative to the tool body and the inner gimbal at the first cant angle; rotating the inner gimbal to the second cant angle; taking a second measurement with the gyro; rotating the outer gimbal to a second position relative to the tool body; and taking a third measurement with the gyro.", "33.The gimbal sensor platform of claim 4, wherein the inner gimbal axis of rotation is canted to the outer gimbal axis of rotation by an angle between 0° and 90°.", "34.The gimbal sensor platform of claim 6, wherein the first cant angle and second cant angle are less than 180° apart." ], [ "<SOH> BACKGROUND OF THE DISCLOSURE <EOH>Knowledge of wellbore placement and surveying is useful for the development of subsurface oil & gas deposits.", "Accurate knowledge of the position of a wellbore at a measured depth, including inclination and azimuth, may be used to attain the geometric target location of, for example, an oil bearing formation of interest.", "Additionally, directional borehole drilling typically relies on one or more directional devices such as bent subs and rotary steering systems to direct the course of the wellbore.", "The angle between the reference direction of the directional device and an external reference direction is referred to as the toolface angle, and determines the direction of deviation of the wellbore.", "Directional drilling proceeds through comparing the placement of the borehole with the desired path, and selecting a toolface angle and other drilling parameters to advance the borehole and correct it towards the planned path.", "Measurement of toolface thus may be a component for borehole steering and placement.", "The measurement of inclination and azimuth of the wellbore may be used in surveying operations.", "Inclination is the angle between the longitudinal axis of a wellbore or a drill string or other downhole tool positioned in a wellbore and the gravity vector, and azimuth is the angle between a horizontal projection of the longitudinal axis and north, whether measured by a magnetometer (magnetic north) or by a gyro (true north).", "One method of determining the orientation and position of a downhole tool with respect to the Earth spin vector is to take a gyro survey, referred to herein as a gyrocompass, to determine a gyro toolface, inclination, and azimuth.", "The gyrocompass utilizes one or more gyroscopic sensors, referred to herein as gyros to detect the Earth's rotation and determine the direction to true north from the downhole tool, the reference direction for a gyro toolface and azimuth.", "However, at high inclination, i.e.", "where the downhole tool is nearly horizontal with respect to gravity, a single-axis gyro substantially orthogonal to the downhole tool may be unable to determine true north to sufficient accuracy.", "Additionally, errors in gyro readings caused by, for example and without limitation, bias errors or mass unbalance, may be undetected and induce error in the determination of true north.", "The determination of orientation, position, inclination, and azimuth of the downhole tool may include determining a gravity toolface or magnetic toolface by using one or more accelerometers or magnetometers respectively.", "Accelerometers may be used to detect the local gravity field, typically dominated by the Earth's gravity, to determine the direction to the center of the Earth.", "This direction may be used as the reference direction for a gravity toolface.", "Magnetometers may similarly be used to detect the local magnetic field, typically dominated by the Earth's magnetic field, to determine the direction to magnetic north.", "This direction may be used as the reference direction for a magnetic toolface.", "However, errors in the sensor readings, such as offset or drift, may be undetected and induce error in the determination of toolface.", "Typically, gravity toolface is utilized except where the inclination is very low, such as, for example and without limitation, 5° or less.", "In low inclinations, cross-axial accelerometers may measure only a small gravity signal.", "At low inclinations, gyro or magnetic toolface is traditionally utilized for orienting toward the target drilling direction due to the large cross-axial signal of the Earth's spin vector or magnetic field." ], [ "<SOH> SUMMARY <EOH>The present disclosure provides for a gimbal sensor platform.", "The gimbal sensor platform may be positionable in a tool body having a longitudinal axis.", "The gimbal sensor platform may include an outer gimbal.", "The outer gimbal may be rotatably coupled to the tool body.", "The gimbal sensor platform may include an outer angular positioning device coupled to the outer gimbal to rotate the outer gimbal relative to the tool body about an outer gimbal axis of rotation.", "The gimbal sensor platform may include an inner gimbal, the inner gimbal rotatably coupled to the outer gimbal.", "The gimbal sensor platform may include an inner angular positioning device coupled to the inner gimbal to rotate the inner gimbal relative to the outer gimbal about an inner gimbal axis of rotation.", "The gimbal sensor platform may include a gyro coupled to the inner gimbal.", "The present disclosure also provides for a method.", "The method may include providing a gimbal sensor platform positioned in a tool body.", "The gimbal sensor platform may include an outer gimbal.", "The outer gimbal may be rotatably coupled to the tool body.", "The gimbal sensor platform may include an outer angular positioning device coupled to the outer gimbal to rotate the outer gimbal relative to the tool body about an outer gimbal axis of rotation.", "The gimbal sensor platform may include an inner gimbal, the inner gimbal rotatably coupled to the outer gimbal.", "The gimbal sensor platform may include an inner angular positioning device coupled to the inner gimbal to rotate the inner gimbal relative to the outer gimbal about an inner gimbal axis of rotation.", "The gimbal sensor platform may include a gyro coupled to the inner gimbal.", "The method may include taking a first measurement with the gyro with the outer gimbal in a first position relative to the tool body and the inner gimbal in a first position relative to the outer gimbal.", "The method may include rotating the inner gimbal to a second position relative to the outer gimbal.", "The method may include taking a second measurement with the gyro.", "The method may include rotating the outer gimbal to a second position relative to the tool body.", "The method may include taking a third measurement with the gyro.", "The present disclosure also provides for a method.", "The method may include providing a gimbal sensor platform positioned in a tool body.", "The gimbal sensor platform may include an outer gimbal.", "The outer gimbal may be rotatably coupled to the tool body.", "The gimbal sensor platform may include an outer angular positioning device coupled to the outer gimbal to rotate the outer gimbal relative to the tool body about an outer gimbal axis of rotation.", "The gimbal sensor platform may include an inner gimbal, the inner gimbal rotatably coupled to the outer gimbal.", "The gimbal sensor platform may include an inner angular positioning device coupled to the inner gimbal to rotate the inner gimbal relative to the outer gimbal about an inner gimbal axis of rotation.", "The inner gimbal axis of rotation may be substantially orthogonal to the outer gimbal axis of rotation.", "The gimbal sensor platform may include an inner limit stop positioned to constrain the rotation of the inner gimbal such that the inner gimbal contacts the limit stop when rotated to a first cant angle relative to the outer gimbal axis of rotation and when rotated to a second cant angle relative to the outer gimbal axis of rotation.", "The gimbal sensor platform may include a gyro coupled to the inner gimbal.", "The method may include taking a first measurement with the gyro with the outer gimbal in a first position relative to the tool body and the inner gimbal at the first cant angle.", "The method may include rotating the inner gimbal to the second cant angle.", "The method may include taking a second measurement with the gyro.", "The method may include rotating the outer gimbal to a second position relative to the tool body.", "The method may include taking a third measurement with the gyro." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a nonprovisional application which claims priority from U.S. provisional application No.", "62/081,936, filed Nov. 19, 2014, hereby incorporated by reference in its entirety.", "TECHNICAL FIELD/FIELD OF THE DISCLOSURE The present disclosure relates to downhole survey tools.", "BACKGROUND OF THE DISCLOSURE Knowledge of wellbore placement and surveying is useful for the development of subsurface oil & gas deposits.", "Accurate knowledge of the position of a wellbore at a measured depth, including inclination and azimuth, may be used to attain the geometric target location of, for example, an oil bearing formation of interest.", "Additionally, directional borehole drilling typically relies on one or more directional devices such as bent subs and rotary steering systems to direct the course of the wellbore.", "The angle between the reference direction of the directional device and an external reference direction is referred to as the toolface angle, and determines the direction of deviation of the wellbore.", "Directional drilling proceeds through comparing the placement of the borehole with the desired path, and selecting a toolface angle and other drilling parameters to advance the borehole and correct it towards the planned path.", "Measurement of toolface thus may be a component for borehole steering and placement.", "The measurement of inclination and azimuth of the wellbore may be used in surveying operations.", "Inclination is the angle between the longitudinal axis of a wellbore or a drill string or other downhole tool positioned in a wellbore and the gravity vector, and azimuth is the angle between a horizontal projection of the longitudinal axis and north, whether measured by a magnetometer (magnetic north) or by a gyro (true north).", "One method of determining the orientation and position of a downhole tool with respect to the Earth spin vector is to take a gyro survey, referred to herein as a gyrocompass, to determine a gyro toolface, inclination, and azimuth.", "The gyrocompass utilizes one or more gyroscopic sensors, referred to herein as gyros to detect the Earth's rotation and determine the direction to true north from the downhole tool, the reference direction for a gyro toolface and azimuth.", "However, at high inclination, i.e.", "where the downhole tool is nearly horizontal with respect to gravity, a single-axis gyro substantially orthogonal to the downhole tool may be unable to determine true north to sufficient accuracy.", "Additionally, errors in gyro readings caused by, for example and without limitation, bias errors or mass unbalance, may be undetected and induce error in the determination of true north.", "The determination of orientation, position, inclination, and azimuth of the downhole tool may include determining a gravity toolface or magnetic toolface by using one or more accelerometers or magnetometers respectively.", "Accelerometers may be used to detect the local gravity field, typically dominated by the Earth's gravity, to determine the direction to the center of the Earth.", "This direction may be used as the reference direction for a gravity toolface.", "Magnetometers may similarly be used to detect the local magnetic field, typically dominated by the Earth's magnetic field, to determine the direction to magnetic north.", "This direction may be used as the reference direction for a magnetic toolface.", "However, errors in the sensor readings, such as offset or drift, may be undetected and induce error in the determination of toolface.", "Typically, gravity toolface is utilized except where the inclination is very low, such as, for example and without limitation, 5° or less.", "In low inclinations, cross-axial accelerometers may measure only a small gravity signal.", "At low inclinations, gyro or magnetic toolface is traditionally utilized for orienting toward the target drilling direction due to the large cross-axial signal of the Earth's spin vector or magnetic field.", "SUMMARY The present disclosure provides for a gimbal sensor platform.", "The gimbal sensor platform may be positionable in a tool body having a longitudinal axis.", "The gimbal sensor platform may include an outer gimbal.", "The outer gimbal may be rotatably coupled to the tool body.", "The gimbal sensor platform may include an outer angular positioning device coupled to the outer gimbal to rotate the outer gimbal relative to the tool body about an outer gimbal axis of rotation.", "The gimbal sensor platform may include an inner gimbal, the inner gimbal rotatably coupled to the outer gimbal.", "The gimbal sensor platform may include an inner angular positioning device coupled to the inner gimbal to rotate the inner gimbal relative to the outer gimbal about an inner gimbal axis of rotation.", "The gimbal sensor platform may include a gyro coupled to the inner gimbal.", "The present disclosure also provides for a method.", "The method may include providing a gimbal sensor platform positioned in a tool body.", "The gimbal sensor platform may include an outer gimbal.", "The outer gimbal may be rotatably coupled to the tool body.", "The gimbal sensor platform may include an outer angular positioning device coupled to the outer gimbal to rotate the outer gimbal relative to the tool body about an outer gimbal axis of rotation.", "The gimbal sensor platform may include an inner gimbal, the inner gimbal rotatably coupled to the outer gimbal.", "The gimbal sensor platform may include an inner angular positioning device coupled to the inner gimbal to rotate the inner gimbal relative to the outer gimbal about an inner gimbal axis of rotation.", "The gimbal sensor platform may include a gyro coupled to the inner gimbal.", "The method may include taking a first measurement with the gyro with the outer gimbal in a first position relative to the tool body and the inner gimbal in a first position relative to the outer gimbal.", "The method may include rotating the inner gimbal to a second position relative to the outer gimbal.", "The method may include taking a second measurement with the gyro.", "The method may include rotating the outer gimbal to a second position relative to the tool body.", "The method may include taking a third measurement with the gyro.", "The present disclosure also provides for a method.", "The method may include providing a gimbal sensor platform positioned in a tool body.", "The gimbal sensor platform may include an outer gimbal.", "The outer gimbal may be rotatably coupled to the tool body.", "The gimbal sensor platform may include an outer angular positioning device coupled to the outer gimbal to rotate the outer gimbal relative to the tool body about an outer gimbal axis of rotation.", "The gimbal sensor platform may include an inner gimbal, the inner gimbal rotatably coupled to the outer gimbal.", "The gimbal sensor platform may include an inner angular positioning device coupled to the inner gimbal to rotate the inner gimbal relative to the outer gimbal about an inner gimbal axis of rotation.", "The inner gimbal axis of rotation may be substantially orthogonal to the outer gimbal axis of rotation.", "The gimbal sensor platform may include an inner limit stop positioned to constrain the rotation of the inner gimbal such that the inner gimbal contacts the limit stop when rotated to a first cant angle relative to the outer gimbal axis of rotation and when rotated to a second cant angle relative to the outer gimbal axis of rotation.", "The gimbal sensor platform may include a gyro coupled to the inner gimbal.", "The method may include taking a first measurement with the gyro with the outer gimbal in a first position relative to the tool body and the inner gimbal at the first cant angle.", "The method may include rotating the inner gimbal to the second cant angle.", "The method may include taking a second measurement with the gyro.", "The method may include rotating the outer gimbal to a second position relative to the tool body.", "The method may include taking a third measurement with the gyro.", "BRIEF DESCRIPTION OF THE DRAWINGS The present disclosure is best understood from the following detailed description when read with the accompanying figures.", "It is emphasized that, in accordance with the standard practice in the industry, various features are not drawn to scale.", "In fact, the dimensions of the various features may be arbitrarily increased or reduced for clarity of discussion.", "FIG.", "1 depicts a cross section of a downhole tool consistent with at least one embodiment of the present disclosure.", "FIG.", "2 depicts a schematic view of a sensor platform consistent with at least one embodiment of the present disclosure.", "FIG.", "3 depicts a schematic view of a sensor platform consistent with at least one embodiment of the present disclosure.", "DETAILED DESCRIPTION It is to be understood that the following disclosure provides many different embodiments, or examples, for implementing different features of various embodiments.", "Specific examples of components and arrangements are described below to simplify the present disclosure.", "These are, of course, merely examples and are not intended to be limiting.", "In addition, the present disclosure may repeat reference numerals and/or letters in the various examples.", "This repetition is for the purpose of simplicity and clarity and does not in itself dictate a relationship between the various embodiments and/or configurations discussed.", "FIG.", "1 depicts downhole survey tool 10 positioned in wellbore 20.Downhole survey tool 10 may be a part of a drill string, tool string, or any other tool positionable in a wellbore.", "In some embodiments, downhole survey tool 10 may be part of a directional drilling string.", "In some embodiments, downhole survey tool 10 may be part of a measurement while drilling (MWD) system.", "In some embodiments, downhole survey tool 10 may be part of a wireline conveyed measurement system.", "In some embodiments, downhole survey tool 10 may be a tool separate from other downhole tools or drill strings.", "Downhole survey tool 10 may include tool body 12.Tool body 12 may include sensor housing 14.Sensor housing 14 may be a space formed in tool body 12.Gimbal sensor platform 100 may be positioned within sensor housing 14.Although depicted as positioned in a tubular downhole survey tool 10, one having ordinary skill in the art with the benefit of this disclosure will understand that gimbal sensor platform 100 may be positionable in any downhole tool or other structure without deviating from the scope of this disclosure.", "For example and without limitation, downhole survey tool 10′ and sensor housing 14′, as depicted in FIG.", "1, may be positioned separately from and within tool body 12.For the purposes of this disclosure, longitudinal axis 15 of downhole survey tool 10 is defined as extending in a direction substantially parallel to wellbore 20 at the position of downhole survey tool 10.As depicted in FIG.", "2, gimbal sensor platform 100 may include outer gimbal 101.Outer gimbal 101 may be rotatably coupled to tool body 12 such that outer gimbal 101 may rotate relative thereto.", "In some embodiments, outer gimbal axis of rotation X may be substantially aligned with or parallel to longitudinal axis 15 of downhole survey tool 10.In some embodiments, outer gimbal axis of rotation X may be out of alignment with or canted to longitudinal axis 15 of tool body 12 of downhole survey tool 10.In some such embodiments, the angle between outer gimbal axis of rotation X and longitudinal axis 15 may define an outer gimbal cant angle, and the direction of outer gimbal axis of rotation X relative to longitudinal axis 15 may be known.", "In some embodiments, outer gimbal 101 may include outer gimbal sensor platform 103.As discussed herein below, one or more sensors may be coupled to outer gimbal sensor platform 103.In some embodiments, outer gimbal 101 may be coupled to tool body 12 by outer angular positioning device 105.Outer angular positioning device 105 may be a torque motor, stepper motor, brushless motor, brushed motor, geared motor, piezoelectric motor, rotary actuator, linear actuator, hydraulic actuator, pneumatic actuator, or combinations thereof.", "Outer angular positioning device 105 may be positioned between outer gimbal 101 and tool body 12 such that actuation of outer angular positioning device 105 may cause rotation of outer gimbal 101 relative to tool body 12.In some embodiments, outer angular position measuring device 107 may be coupled between outer gimbal 101 and tool body 12.Outer angular position measuring device 107 may measure the relative rotation between outer gimbal 101 and tool body 12.Outer angular positioning device 107 may be any device capable of measuring the relative rotation between outer gimbal 101 and tool body 12, and may include, for example and without limitation, a resolver, optical encoder, capacitive encoder, magnetic encoder, rotary potentiometer, rotary variable differential transformer, synchro, or combinations thereof.", "In some embodiments, wherein outer angular positioning device 105 is a stepper motor, the relative rotation between outer gimbal 101 and tool body 12 may be determined at least in part by counting the number of steps taken by the stepper motor.", "In some embodiments, one or more outer limit stops 102 as discussed further herein below may be included to, for example and without limitation, provide an index or reference location for the stepper motor.", "One having ordinary skill in the art with the benefit of this disclosure will understand that the specific depiction of outer angular positioning device 105 and outer angular position measuring device 107 in the accompanying figures is merely exemplary and is not intended to limit the scope of this disclosure.", "For example, in some embodiments, outer angular position measuring device 107 may be located within or as a part of outer angular positioning device 105.In other embodiments, one or both of outer angular positioning device 105 and outer angular position measuring device 107 may be positioned away from outer gimbal axis of rotation X, and one or more axles (not shown) may couple outer gimbal 101 to tool body 12.One having ordinary skill in the art with the benefit of this disclosure will understand that additional mechanisms, including, for example and without limitation, bearings, gear boxes, etc.", "may be used without deviating from the scope of this disclosure.", "In some embodiments, gimbal sensor platform 100 may include inner gimbal 111.Inner gimbal 111 may be rotatably coupled to outer gimbal 101 such that inner gimbal 111 may rotate relative thereto.", "In some embodiments, inner gimbal axis of rotation Y may be offset by cant angle K from outer gimbal axis of rotation X.", "In some such embodiments, cant angle K may be preselected.", "In some embodiments, inner gimbal axis of rotation Y may be substantially perpendicular to outer gimbal axis of rotation X, i.e.", "a case where cant angle K is 90°.", "In some embodiments, cant angle K may be between 0° and 90°.", "In some embodiments, cant angle K may be between 5° and 35°.", "In some embodiments, cant angle K may be between 10° and 20°.", "In some embodiments, inner gimbal 111 may include inner gimbal sensor platform 113.As discussed herein below, one or more sensors may be coupled to inner gimbal sensor platform 113.In some embodiments, cant angle K may at least partially determine the outer diameter of gimbal sensor platform 100.In some embodiments, cant angle K may be selected such that gimbal sensor platform 100 has a desired outer diameter.", "In some embodiments, inner gimbal 111 may be coupled to outer gimbal 101 by inner angular positioning device 115.Inner angular positioning device 115 may be a torque motor, stepper motor, brushless motor, brushed motor, geared motor, piezoelectric motor, rotary actuator, linear actuator, hydraulic actuator, pneumatic actuator, or combinations thereof.", "Inner angular positioning device 115 may be positioned between inner gimbal 111 and outer gimbal 101 such that actuation of inner angular positioning device 115 may cause rotation of inner gimbal 111 relative to outer gimbal 101.In some embodiments, inner angular position measuring device 117 may be coupled between inner gimbal 111 and outer gimbal 101.Inner angular position measuring device 117 may measure the relative rotation between inner gimbal 111 and outer gimbal 101.Inner angular positioning device 117 may be any device capable of measuring the relative rotation between outer gimbal 101 and inner gimbal 111, and may include, for example and without limitation, a resolver, optical encoder, capacitive encoder, magnetic encoder, rotary potentiometer, rotary variable differential transformer, synchro, or combinations thereof.", "In some embodiments, wherein inner angular positioning device 115 is a stepper motor, the relative rotation between outer gimbal 101 and inner gimbal 111 may be determined at least in part by counting the number of steps taken by the stepper motor.", "In some embodiments, one or more inner limit stops 112 as discussed further herein below may be included to, for example and without limitation, provide an index or reference location for the stepper motor.", "One having ordinary skill in the art with the benefit of this disclosure will understand that the specific depiction of inner angular positioning device 115 and outer angular position measuring device 117 in the accompanying figures is merely exemplary and is not intended to limit the scope of this disclosure.", "For example, in some embodiments, inner angular position measuring device 117 may be located within or as a part of inner angular positioning device 115.In other embodiments, one or both of inner angular positioning device 115 and inner angular position measuring device 117 may be positioned away from inner gimbal axis of rotation Y, and one or more axles (not shown) may couple inner gimbal 111 to outer gimbal 101.One having ordinary skill in the art with the benefit of this disclosure will understand that additional mechanisms, including, for example and without limitation, bearings, gear boxes, etc.", "may be used without deviating from the scope of this disclosure.", "In operation, by rotating outer gimbal 101, outer gimbal sensor platform 103 may be rotated about outer gimbal axis of rotation X.", "Likewise, by rotating inner gimbal 111, inner gimbal sensor platform 113 may be rotated about inner gimbal axis of rotation Y.", "By combining rotation of outer gimbal 101 and inner gimbal 111, sensors coupled to inner gimbal sensor platform 113 may be repositionable in a variety of orientations while not requiring slewing, sliding, or rotation of downhole survey tool 10.Likewise, sensors coupled to outer gimbal sensor platform 103 may be repositionable by rotation of outer gimbal 101 about outer gimbal axis of rotation X while not requiring slewing, sliding, or rotation of downhole survey tool 10.In some embodiments, one or both of outer gimbal 101 and inner gimbal 111 may be rotatable by at least a full rotation or only by a partial rotation.", "In some embodiments, one or more outer limit stops 102, as depicted in FIG.", "3, may be coupled to tool body 12 such that outer gimbal 101 contacts outer limit stops 102 when outer gimbal 101 is positioned at a first rotational position or a second rotational position relative to tool body 12.One having ordinary skill in the art with the benefit of this disclosure will understand that outer limit stops 102 as used herein may be any structure or structures which limit the rotation of outer gimbal 101 with respect to tool body 12, and are not intended to be limited to a stop plate as depicted in FIG.", "3.In some embodiments, for example and without limitation, such as depicted in FIG.", "3, inner gimbal 111′ may have inner gimbal axis of rotation Y′ substantially orthogonal to outer gimbal axis of rotation X.", "In such an embodiment, the cant angle K′ of inner gimbal 111′ may be varied by rotation of inner gimbal 111′ along inner gimbal axis of rotation Y′.", "Inner gimbal 111′ may, for example, change position to change from cant angle K′ to a second cant angle, depicted as second cant angle K″.", "In some embodiments, outer gimbal 101 and inner gimbal 111 may be constrained in movement by one or more limit stops or stop plates.", "In some embodiments, one or more inner limit stops 112 may be coupled to outer gimbal 101 such that inner gimbal 111′ contacts inner limit stops 112 when inner gimbal 111′ is positioned at a first cant and a second cant, depicted in FIG.", "3 as cant angles K′ and K″.", "Although depicted only with respect to inner gimbal 111′, one having ordinary skill in the art with the benefit of this disclosure will understand that inner limit stops 112 as used herein may be any structure or structures which limit the rotation of inner gimbal 111′ with respect to outer gimbal 101, and are not intended to be limited to a stop plate as depicted in FIG.", "3.In such an embodiment, cant angle K′ between inner gimbal 111′ and outer gimbal 101 is varied by rotation of inner gimbal 111′ about inner gimbal axis of rotation Y′.", "In some such embodiments, inner gimbal 111′ may contact an inner limit stop 112 when rotated to a first cant angle K′ and when rotated to a second cant angle K″.", "In some embodiments, inner limit stops 112 may be positioned such that cant angle K′ and K″ may be substantially equal in magnitude in opposite direction relative to outer gimbal axis of rotation X.", "In some embodiments, cant angle K′ may be substantially 45° from outer gimbal axis of rotation X, and cant angle K″ may be substantially 45° from outer gimbal axis of rotation X in the opposite direction.", "In such an embodiment, inner gimbal sensor platform 113 may be rotated substantially 90°.", "In some embodiments, cant angle K′ and K″ may be unequal.", "In some embodiments, cant angles K′ and K″ may be between 1° and 45°.", "In some embodiments, cant angles K′ and K″ may be between 5° and 35°.", "In some embodiments, cant angles K′ and K″ may be between 10° and 20°.", "In operation, by rotating outer gimbal 101, outer gimbal sensor platform 103 may be rotated about outer gimbal axis of rotation X.", "Likewise, by rotating inner gimbal 111′, inner gimbal sensor platform 113 may be moved from the first cant angle K′ to the second cant angle K″.", "By combining rotation of outer gimbal 101 and inner gimbal 111′, sensors coupled to inner gimbal sensor platform 113 may be repositionable in a large variety of orientations while not requiring slewing, sliding, or rotation of downhole survey tool 10.Likewise, sensors coupled to outer gimbal sensor platform 103 may be repositionable by rotation of outer gimbal 101 about outer gimbal axis of rotation X while not requiring slewing, sliding, or rotation of downhole survey tool 10.In some embodiments, one or both of outer gimbal 101 and inner gimbal 111′ may be rotatable by at least a full rotation or only by a partial rotation.", "In a survey operation, with reference to FIG.", "2, downhole survey tool 10 may be positioned within wellbore 20 at a position desired to be surveyed, referred to herein as the survey point.", "Outer gimbal 101 may be rotated between two or more positions.", "At each position of outer gimbal 101, inner gimbal 111 may likewise be rotated among two or more positions.", "At each position of outer gimbal 101, one or more sensor readings may be taken from sensors positioned in outer gimbal sensor platform 103 at each position.", "At each position of inner gimbal 111 when at each position of outer gimbal 101, sensor readings may be taken from sensors positioned in inner gimbal sensor platform 113.By rotating outer gimbal 101 and inner gimbal 111, the sensitive axes of any sensors coupled to outer gimbal sensor platform 103 and inner gimbal sensor platform 113 may be moved while not requiring slewing, sliding, or rotation of downhole survey tool 10.In some embodiments, the orientation of outer gimbal 101 and inner gimbal 111 may be determined by one or more of gravity, magnetic, or inertial reference, or may be measured relative to downhole sensor tool 10.In some embodiments, utilizing a gravity reference, one or more accelerometers may be utilized to determine the orientation of outer gimbal 101 and inner gimbal 111 relative to the Earth's gravity field.", "As depicted in FIG.", "2, for example and without limitation, in some embodiments, one or more accelerometers 131 may be coupled to tool body 12.Accelerometers 131 may detect the Earth's gravity field relative to tool body 12.Outer angular position measuring device 107 may be utilized to detect the relative orientation between tool body 12 and outer gimbal 101.Inner angular position measuring device 117 may be utilized to detect the relative orientation between inner gimbal 111 and outer gimbal 101.One having ordinary skill in the art with the benefit of this disclosure will understand that although three accelerometers 131 are depicted in FIG.", "2, fewer or additional accelerometers may be utilized without deviating from the scope of this disclosure.", "In some embodiments, one or more accelerometers may be coupled to outer gimbal sensor platform 103.For example, in some embodiments, a single accelerometer 141 may be coupled to outer gimbal sensor platform 103.In some embodiments, accelerometer 141 may be positioned such that its sensitive axis is at an angle or canted relative to outer gimbal axis of rotation X.", "In some embodiments, accelerometer 141 may be positioned such that its sensitive axis is substantially orthogonal to outer gimbal axis of rotation X. Sensor readings from accelerometer 141 may be taken at various orientations of outer gimbal 101 to determine the orientation of outer gimbal 101 relative to the Earth's gravity field.", "In some embodiments, comparing the sensor readings may allow any bias error of the accelerometer to be determined.", "In some embodiments, a second accelerometer 143 may be coupled to outer gimbal sensor platform 103.In some embodiments, second accelerometer 143 may be positioned such that its sensitive axis is substantially orthogonal to that of accelerometer 141.In embodiments in which the sensitive axis of accelerometer 141 is oriented substantially orthogonally to outer gimbal axis of rotation X, second accelerometer 143 may be positioned such that its sensitive axis is mutually orthogonal to that of accelerometer 141 and outer gimbal axis of rotation X.", "In some embodiments, second accelerometer 143 may be positioned such that its sensitive axis is substantially parallel to outer gimbal axis of rotation X.", "In some embodiments, a third accelerometer 145 may be coupled to outer gimbal sensor platform 103.In some embodiments, accelerometers 141, 143, and 145 may be oriented such that their sensitive axes are mutually orthogonal.", "In some embodiments, accelerometers 141, 143, and 145 are oriented such that no sensitive axis of an accelerometer is aligned with outer gimbal axis of rotation X. Rotation of outer gimbal 101 may, for example and without limitation, allow for bias error in accelerometers 141, 143, 145 to be detected or for failure to be detected.", "In some embodiments, more than three accelerometers may be coupled to outer gimbal sensor platform 103 without deviating from the scope of this disclosure.", "In some embodiments wherein no accelerometers are coupled to inner gimbal sensor platform 113, the relative orientation between inner gimbal 111 and outer gimbal 101 may be determined by inner angular position measuring device 117.In some embodiments, such as that depicted in FIG.", "3, wherein inner limit stops 112 are utilized, the relative orientation between inner gimbal 111′ and outer gimbal 101 may be determined from the known cant angles K′ and K″ as discussed herein above.", "In some embodiments, one or more accelerometers may be coupled to inner gimbal sensor platform 113.For example, in some embodiments, a single accelerometer 151 may be coupled to inner gimbal sensor platform 113.In some embodiments, accelerometer 151 may be positioned such that its sensitive axis is at an angle or canted relative to inner gimbal axis of rotation Y.", "In some embodiments, accelerometer 151 may be positioned such that its sensitive axis is substantially orthogonal to inner gimbal axis of rotation Y. Sensor readings from accelerometer 151 may be taken at various orientations of outer gimbal 101 to determine the orientation of outer gimbal 101 relative to the Earth's gravity field.", "In some embodiments, comparing the sensor readings may allow any bias error of the accelerometer to be determined.", "In some embodiments, a second accelerometer 153 may be coupled to inner gimbal sensor platform 113.In some embodiments, second accelerometer 153 may be positioned such that its sensitive axis is substantially orthogonal to that of accelerometer 151.In embodiments in which the sensitive axis of accelerometer 151 is oriented substantially orthogonally to inner gimbal axis of rotation Y, second accelerometer 153 may be positioned such that its sensitive axis is mutually orthogonal to that of accelerometer 151 and inner gimbal axis of rotation Y.", "In some embodiments, second accelerometer 153 may be positioned such that its sensitive axis is substantially parallel to inner gimbal axis of rotation Y.", "In some embodiments, a third accelerometer 155 may be coupled to inner gimbal sensor platform 113.In some embodiments, accelerometers 151, 153, and 155 may be oriented such that their sensitive axes are mutually orthogonal.", "In some embodiments, accelerometers 151, 153, and 155 are oriented such that no sensitive axis of an accelerometer is aligned with inner gimbal axis of rotation Y. Rotation of outer gimbal 101 or inner gimbal 111 may, for example and without limitation, allow for bias error in accelerometers 151, 153, 155 to be detected or for failure to be detected.", "In some embodiments, more than three accelerometers may be coupled to inner gimbal sensor platform 113 without deviating from the scope of this disclosure.", "In some embodiments, in which no accelerometers are coupled to outer gimbal sensor platform 103, the relative orientation between inner gimbal 111 and outer gimbal 101 may be determined utilizing inner angular position measuring device 117.In some embodiments, in which accelerometers are positioned in two or more of inner gimbal sensor platform 113, outer gimbal sensor platform 103, and tool body 12, readings of each accelerometer and inner angular position measuring device 117 and outer angular position measuring device 107 may be utilized to, for example and without limitation, detect bias error or detect failure on any of the accelerometers.", "In some embodiments, utilizing a magnetic reference, one or more magnetometers may be utilized to determine the orientation of outer gimbal 101 and inner gimbal 111 relative to the local magnetic field.", "Magnetometers may be coupled to tool body 12 (magnetometers 137), coupled to outer gimbal sensor platform 103 (magnetometers 147), or coupled to inner gimbal sensor platform 113 (magnetometers 157).", "Magnetometers may be positioned and utilized in much the same way as accelerometers as discussed herein above.", "In some embodiments, positioning gyro 161 may be coupled to outer gimbal sensor platform 103.Positioning gyro 161 may, for example and without limitation, be utilized to detect rotation of outer gimbal 101 relative to an inertial reference frame.", "Although not depicted, one or more positioning gyros may be positioned in inner gimbal 111 or tool body 12.One having ordinary skill in the art with the benefit of this disclosure will understand that a combination of angular position measuring devices, accelerometers, positioning gyro, and magnetometers may be utilized to determine the orientations of outer gimbal 101 and inner gimbal 111.In some embodiments, gyro 121 may be coupled to inner gimbal sensor platform 113.Gyro 121 may, in some embodiments, be a single degree of freedom gyro whose sensitive axis is substantially perpendicular to inner gimbal axis of rotation Y.", "By rotating outer gimbal 101 and inner gimbal 111, the sensitive axis of gyro 121 may be rotated through a series of orientations with respect to downhole survey tool 10.By taking multiple readings at various orientations of gyro 121, measurements of the Earth spin vector may be obtained where a fixed, single axis gyro may be incapable of accurate measurement, such as at high inclinations.", "In some embodiments, outer gimbal 101 may be rotated to two or more positions.", "At each position, the orientation of outer gimbal 101 may be determined as discussed herein above.", "In some embodiments, outer gimbal 101 may be rotated to three positions.", "In some such embodiments, the three positions may be substantially 120° apart.", "In some such embodiments, inner gimbal 111 may be stationary relative to outer gimbal 101 while outer gimbal 101 is rotated.", "In some embodiments, at each position of outer gimbal 101, inner gimbal 111 may be rotated to two or more positions.", "In some embodiments, inner gimbal 111 may be rotated to two positions which are substantially 180° apart.", "In other embodiments, inner gimbal 111 may be rotated to two positions which are less than 180° apart, such as in an embodiment as discussed herein above with respect to FIG.", "3.In some embodiments, gyro 121 may take a measurement at each position of inner gimbal 111 and outer gimbal 101.In some embodiments, gyro 121 may be positioned such that its sensitive axis is aligned in three orthogonal axes, allowing the three spatial components of the Earth spin vector to be measured using a single axis gyro 121.In some embodiments, gyro 121 may be positioned and measurements taken to identify, detect, or estimate any gyro sensor bias or gyro mass unbalance.", "Additionally, in some embodiments, by rotating inner gimbal 111 and outer gimbal 113, the readings from gyro 121 may be used to detect or estimate azimuth, gyro toolface, any gyro sensor bias, gyro mass unbalance, or other gyro sensor errors.", "In some embodiments, readings from gyro 121 may be combined with other sensor readings, including readings from one or more of accelerometers 141, 143, 145, 151, 153, and 155; magnetometers 147; outer angular position measuring device 107; inner angular position measuring device 117; or a combination thereof to detect or estimate azimuth, gyro toolface, any gyro sensor bias, gyro mass unbalance, or other gyro sensor errors.", "The detected or estimated gyro sensor bias and gyro mass unbalance may be used, for example and without limitation, to improve the accuracy of the determined gyro toolface and azimuth of downhole survey tool 10 based on the measurements of gyro 121.In some embodiments, the rotation of outer gimbal 101 and inner gimbal 111 may be selected such that a first measurement from gyro 121 is taken with gyro 121 oriented in a first direction and a second measurement is taken from gyro 121 with gyro 121 oriented in a direction opposite that of the first measurement.", "In some embodiments, multiple measurements of gyro 121 may be taken such that a first, second, and third measurement of gyro 121 are taken each at different orientations by rotating one or both of inner gimbal 111 and outer gimbal 101.In some embodiments, three or more gyro readings at different orientations of gyro 121 may be utilized.", "In some embodiments, three gyro readings may be taken such that the sensitive axis of gyro 121 is oriented along one of three mutually orthogonal axes during each measurement.", "In some embodiments, six or more gyro readings may be utilized.", "In some embodiments, six gyro readings may be taken such that three gyro readings may be taken such that the sensitive axis of gyro 121 is oriented one of three mutually orthogonal axes during each measurement, and the other three are taken along the three mutually orthogonal axes in directions opposite the first three measurements.", "In some embodiments, wherein inner gimbal 111 is canted to outer gimbal 101, three or more measurements may be taken by gyro 121 by rotation of outer gimbal 101.In some such embodiments, where gyro 121 is not affected by mass unbalance or other sensor errors, azimuth may be determined without rotation of inner gimbal 111.In some embodiments in which gyro 121 is affected by mass unbalance, a recent estimate of mass unbalance or other sensor errors may be utilized or inner gimbal 111 may be actuated as described herein to determine azimuth, gyro toolface, mass unbalance or other sensor errors.", "One having ordinary skill in the art with the benefit of this disclosure will understand that inner gyro sensor platform 113 is not restricted to having only a single gyro sensor coupled thereto.", "For example and without limitation, a second gyro, 121′ coupled thereto.", "In such an embodiment, fewer readings from gyro 121 and 121′ may be used to generate redundant measurements to, for example and without limitation, improve accuracy or detect bias errors or mass unbalance.", "In some embodiments, utilizing multiple gyros 121, 121′, a desired number of measurements may be made with fewer reorientations of outer gimbal 101 and inner gimbal 111 than embodiments utilizing a single gyro 121.In some embodiments, gyros 121, 121′, each measuring a single bias free cross-axis component of the Earth's spin vector as well as a bias free long axis component of the Earth's spin vector, may be utilized.", "In such an embodiment, the measurements may be made at 4 positions: a first position of outer gimbal 101 and inner gimbal 111 at a first and second position, and a second position of outer gimbal 101 offset from the first position by substantially 180° with inner gimbal 111 in the first and second positions.", "In some embodiments, gyro 121 or multiple gyros 121, 121′, may have multiple sensitive input axes.", "Furthermore, by rotating outer gimbal 101 and inner gimbal 111, measurements of any other sensors coupled thereto, such as, for example and without limitation, accelerometers 141, 143, 145, 151, 153, and 155 or magnetometers 147, may be taken, and may be used to determine any bias error of these sensors.", "In some embodiments, two or more measurements from the sensors may be taken with the sensors positioned in different orientations by movement of inner gimbal 111, outer gimbal 101, or both.", "In some embodiments, a first measurement may be compared to a second measurement of a sensor taken after a movement of one or both of inner gimbal 111 and outer gimbal 101.Because the measured field is generally static, comparison of the first and second measurements (or any additional measurements taken) may allow bias or other error to be identified.", "In some embodiments, measurements from the sensors may be utilized to calculate azimuth, inclination, magnetic toolface, gravity toolface, or gyro toolface.", "Sensors mounted to inner gimbal 111, outer gimbal 101, and tool body 12 may be utilized to determine relative orientation of inner gimbal 111 and outer gimbal 101 relative to each other and relative to tool body 12.The determination of the orientation of gyro 121 may be determined at least in part based on measurements of accelerometers 141, 143, 145, 151, 153, and 155; magnetometers 147; outer angular position measuring device 107; inner angular position measuring device 117; or a combination thereof.", "In some embodiments, as understood by one having ordinary skill in the art with the benefit of this disclosure, more than two gyros or multi-axis gyros may be used without deviating from the scope of this disclosure.", "In some embodiments, additional gyros may be used to, for example, add redundant readings or account for sensor failure.", "In some embodiments, rotation of outer gimbal 101 and inner gimbal 111 may be continuous or discontinuous.", "Rotation of outer gimbal 101 and inner gimbal 111 need not be in a single direction.", "In some embodiments, azimuth, computed Earth's rate, bias, mass unbalance, and other sensor parameters which may include values produced by a set of equations may be identified, determined or estimated.", "In some embodiments, a closed calculation may be utilized.", "In such an embodiment, measurements from any gyros may be re-expressed in terms of cross axis components (main and quadrature), as well as a pair of bias components.", "The common mode of the bias components is the true sensor bias, while the difference is the signal.", "The cross-axis components may be rotated into in-phase and out of phase gyro signals: the out of phase signal may be proportional to the sine of azimuth, and the difference bias may be combined with the out of phase signal to generate a value proportional to the cosine of azimuth.", "As an example, in an embodiment in which inner gimbal axis of rotation Y′ is substantially perpendicular to outer gimbal axis of rotation X, such as the embodiment depicted in FIG.", "3, determination of the azimuth of downhole survey tool 10 may involve a conversion of the measurements of a gyro into in-phase, out of phase, and bias components for each of the cant angles K′, K″.", "As used herein, ERH is defined as the horizontal component of Earth's rotation rate; ERV is defined as the vertical component of Earth's rotation rate; I is the inclination of tool body 12; AZ is the azimuth of tool body 12; MUIX is defined as equivalent to a mass shift along the input axis; MUSX is defined as equivalent to a mass shift along the spin axis of gyro; TuOi is defined as the cant angle K of inner gimbal 111 or 111′ wherein subscript i corresponds to the cant angle K for each successive position of inner gimbal 111 or 111′; TFOn and TFOi are defined as the offset of outer gimbal 101 from tool body 12 as read from outer angular position measuring device 107; ACn is the output of a cross-axis accelerometer mounted to outer gimbal 101; ALn is the output of an accelerometer whose sensitive axis is aligned with the longitudinal axis 15 of tool body 12; AX′, AY′, and AZ′ are mutually orthogonal components of gravity referenced to tool body 12 such that AZ′ is the component of gravity in-line with the longitudinal axis 15 of tool body 12; N is the number of angular positions to which outer gimbal 101 is rotated; subscript n or i corresponds to the reading for each successive angular position of outer gimbal 101 with respect to the tool body; TfH is defined as the gravity toolface of tool body 12 also known as a high-side toolface, or the rotation angle about the longitudinal axis 15 of tool body 12 with respect to the gravity vector; IP is defined as the portion of the gyro output that is in-phase with gravity, that is, the vertical component of the gyro output; and OP is defined as the portion of the gyro output that is out of phase with gravity, that is, the horizontal component of the gyro output.", "One having ordinary skill in the art with the benefit of this disclosure will understand that for aligned sensors, AX′ may be given by: A X ′ = 2 N  ∑ n = 1 N  A   C n  cos   TF On AY′ may be given by: A Y ′ = 2 N  ∑ n = 1 N  A   C n  sin   TF On AZ′ may be given by: A Z ′ = 1 N  ∑ n = 1 N  A   L n From which I may be determined by: I = tan - 1 ( A X   ′ 2 + A Y   ′ 2 - A Z   ′ ) And TfH may be determined by: Tf H = tan - 1  ( - A Y   ′ A X   ′ ) IP may be given by: (ERH cos(Az)cos(I)+(MUSX+ERV)*sin(I))*cos(TuOi) And OP may be given by −(ERH sin(Az)+MUIX*sin(I))*cos(TuOi) As used in the following equations, bias includes the along-hole portion of the Earth's rate as well as gyro bias.", "For a fixed inner gimbal cant angle, TuO, the along-hole component of Earth's rate does not change and therefore looks like a bias as the position of outer gimbal 101 is changed.", "One having ordinary skill in the art with the benefit of this disclosure will understand that for aligned sensors, bias may be given by −(ERH cos(Az)sin(I)−(MUSX+ERV)*cos(I)) sin(TuOi).", "As used in the following equations, Gbias is defined as gyro bias, or the portion of the gyro output that does not change with gyroscope orientation change.", "Given a series of gyro measurements GOn at a fixed cant angle Tuo and a series of toolface offset angles, i.e.", "positions of outer gimbal 101, the following system of equations may be solved to determine the in-phase (IP), out of phase (OP), and bias components: GO 0 = IP   cos  ( Tf o 0 ) + OP   sin  ( Tf o 0 ) + bias GO 1 = IP   cos  ( Tf o 1 ) + OP   sin  ( Tf o 1 ) + bias ⋮   ⋮ GO n = IP   cos  ( Tf o n ) + OP   sin  ( Tf o n ) + bias Assuming an existing determination of inclination (I) and highside toolface (TfH), both pairs of in-phase and out-of-phase components may be converted into one component in-phase and another out of phase with gravity.", "Dividing both phases by the cosine of the fixed cant angle TuO, the in-phase component may be given by: ERH cos(Az)cos(I)+(ERV+MUSX)sin(I) and the out of phase component may be proportional to: −ERH sin(Az)+MUSX)sin(I) Although these equations assume no misalignment angles, one having ordinary skill in the art with the benefit of this disclosure will understand that these effects may be identified and compensated for.", "With the pair of bias terms, dividing the difference by the sine of cant angle TuO may be proportional to: ERH cos(Az)sin(I)−(ERV+MUSX)cos(I) Multiplying this equation by the sine of inclination and the in-phase with gravity by the cosine of inclination and adding the two, the result is: ERH cos(Az) Multiplying the in-phase by sine of inclination and subtracting the scaled bias difference, MUSX may be calculated from: (ERV+MUSX) The sine of azimuth term may be generated or predicted by subtracting off the influence of the input axis mass unbalance MUIX.", "The input axis mass unbalance may be better behaved than that of the spin axis, and may be corrected such that the RMS value of these components is equal to ERH.", "In some embodiments, a forward model is used to determine azimuth, computed Earth's rate, bias, and mass unbalance, and may utilize a model for the measurement of gyro 121 at each position as discussed herein above.", "In some such embodiments, pseudo-measurements may be included in each model.", "Pseudo-measurements may, for example and without limitation, constrain parameters or groups of parameters.", "The final set of parameters may be determined or estimated from minimizing a measure of error between the modeled and measured values.", "As an example of a forward model solution, a model of the expected gyro outputs GOi for a given inclination I and highside toolface TfH, and azimuth Az may be generated or predicted.", "For the purposes of this disclosure, the subscript “i” denotes the various known values of toolface offset TfOi and cant angle TuOi.", "In some embodiments, the model output may be: GO i = [ ( ER H  cos  ( Az )  cos  ( I ) + ( MU SX + ER V ) * sin  ( I ) )  cos  ( Tf H + Tf o i ) - ( ER H  sin  ( Az ) + MU IX * sin  ( I ) )  sin  ( Tf H + Tf o i ) ]  cos  ( Tu O i ) - ( ER H  cos  ( Az )  sin  ( I ) - ( MU SX + ER V ) * cos  ( I ) )  sin  ( Tu O i ) + Gbias Gyro bias (Gbias), MUSX and MUIX may be included as part of an azimuth cost function, although calibrated values may be utilized instead.", "Solving the cost function may include minimizing for some measure of the differences between the measured and modelled gyro outputs at the various toolface and cant angles.", "In some embodiments, a numerical optimizer, M-estimators, and/or adaptive filters may be utilized.", "In some embodiments, differences between the modeled and measured outputs may be the sum of the square of the differences, the sum of the absolute value of the differences, or another model.", "In some embodiments, pre-established values of MUSX and MUIX may be used as starting values in the optimization.", "In some embodiments, values of the estimated parameters from along-hole measurements and cross-axis measurements may be fused using for example but not limited to a complimentary filter.", "In some embodiments inner gimbal 111 may be fixed relative to outer gimbal 101.In some such embodiments, downhole survey tool 10 may be operated in attitude reference mode as understood in the art.", "One having ordinary skill in the art with the benefit of this disclosure will understand that the positions at which measurements are made from gyro 121 sensors do not have to be in antiparallel directions to effect an estimation of the current gyro bias, where bias is reasonably stable and that the orientation of the tool body 12 is substantially stable.", "In other words, while a single pair of antiparallel readings could be performed to make a simple determination of the basic sensor bias, this sequencing is not necessary for that determination.", "Electrical connections between a power source (not shown) and sensors on outer gimbal sensor platform 103 and inner gimbal sensor platform 113 may be made using any system known in the art, including, for example and without limitation, flexible cables and slip rings.", "In some embodiments, gyro 121 may be floated.", "As understood by one having ordinary skill in the art with the benefit of this disclosure, floating the gyro may, for example and without limitation, reduce the susceptibility of gyro 121 to damage from shock and vibration.", "In some embodiments, in addition to azimuth, sensor platform 100 may be utilized to determine gyro toolface, status of gyro 121, or azimuth determination uncertainty.", "The foregoing outlines features of several embodiments so that a person of ordinary skill in the art may better understand the aspects of the present disclosure.", "Such features may be replaced by any one of numerous equivalent alternatives, only some of which are disclosed herein.", "One of ordinary skill in the art should appreciate that they may readily use the present disclosure as a basis for designing or modifying other processes and structures for carrying out the same purposes and/or achieving the same advantages of the embodiments introduced herein.", "One of ordinary skill in the art should also realize that such equivalent constructions do not depart from the spirit and scope of the present disclosure and that they may make various changes, substitutions, and alterations herein without departing from the spirit and scope of the present disclosure." ] ]
Patent_15872830
[ [ "METHOD AND APPARATUS FOR CARTRIDGE-BASED CARBONATION OF BEVERAGES", "Systems, methods and cartridges for carbonating or otherwise dissolving gas in a precursor liquid, such as water, to form a beverage.", "A gas source can be provided in a cartridge which is used to generate gas that is dissolved into the precursor liquid.", "A beverage medium, such as a powdered drink mix or liquid syrup, may be provided in the same, or a separate cartridge as the gas source and mixed with the precursor liquid to form a beverage.", "The use of one or more cartridges for the gas source and/or beverage medium may make for an easy to use and mess-free system for making sparkling beverages, e.g., in the consumer's home." ], [ "1.A beverage making system, comprising: a beverage precursor liquid supply including a reservoir to hold a precursor liquid; an ice compartment separated from the reservoir by an impermeable barrier and thermally coupled to the precursor liquid in the reservoir to cool the precursor liquid; a cartridge chamber arranged to hold a cartridge having a liquid precursor to form a beverage; a carbon dioxide gas supply arranged to conduct carbon dioxide gas, under pressure greater than an ambient pressure, from the cartridge chamber to beverage precursor liquid provided via the beverage precursor liquid supply to carbonate the precursor liquid; wherein the system is configured to dispense carbonated precursor liquid that is mixed with a beverage medium in the cartridge chamber.", "2.The system of claim 1, wherein the carbon dioxide gas supply is connected to a carbon dioxide gas source that is made of a solid material.", "3.The system of claim 2, wherein the system is arranged to mix the beverage medium with precursor liquid to form a beverage such that none of the beverage contacts the carbon dioxide gas source.", "4.The system of claim 1, wherein the carbon dioxide gas supply is connected to a carbon dioxide gas cartridge.", "5.The system of claim 1, wherein the system is arranged to use the cartridge over a period of time less than about 120 seconds to form a carbonated liquid having a volume of between 100-1000 ml and a carbonation level of about 2 to 4 volumes.", "6.The system of claim 1, further comprising a mixing chamber arranged to mix the precursor liquid and the beverage medium outside of the cartridge.", "7.The system of claim 1, the cartridge chamber is arranged to pierce the cartridge to form an opening through which beverage medium exits the cartridge chamber.", "8.The system of claim 1, further including a valve is configured to control the flow of beverage through a nozzle incorporated into the cartridge mixes the precursor liquid and beverage medium to aerate the beverage as the beverage flows.", "9.The system of claim 1, further including a portion of the precursor liquid is routed through the cartridge to expel the beverage medium from the cartridge to a cup while a remaining portion of the precursor liquid is routed directly to the cup.", "10.The system of claim 1, further including a chiller circuit to chill the precursor liquid.", "11.The system of claim 10, wherein the chiller circuit includes a thermoelectric device.", "12.The system of claim 10, wherein the chiller circuit includes a heat exchanger in thermal communication with the ice compartment.", "13.The system of claim 1, wherein the precursor liquid is cooled prior to dissolving carbon dioxide into the precursor liquid.", "14.The system of claim 1, wherein the precursor liquid is cooled after dissolving carbon dioxide into the precursor liquid.", "15.A beverage making system, comprising: a beverage precursor liquid supply including a reservoir to hold a precursor liquid; an ice compartment separated from the reservoir by an impermeable barrier and thermally coupled to the precursor liquid in the reservoir to cool the precursor liquid; a cartridge chamber arranged to hold a cartridge having a liquid precursor to form a beverage; a carbon dioxide gas supply is connected to a carbon dioxide gas cartridge and arranged to conduct carbon dioxide gas, under pressure greater than an ambient pressure, from the cartridge chamber to beverage precursor liquid provided via the beverage precursor liquid supply to carbonate the precursor liquid; wherein the system is configured to dispense carbonated precursor liquid that is mixed with beverage medium in the cartridge chamber; wherein the cartridge chamber is arranged to pierce the cartridge to form an opening through which beverage medium exits the cartridge chamber.", "16.The system of claim 15, wherein the system is arranged to use the cartridge over a period of time less than about 120 seconds to form a carbonated liquid having a volume of between 100-1000 ml and a carbonation level of about 2 to 4 volumes.", "17.The system of claim 15, further comprising a mixing chamber arranged to mix the precursor liquid and the beverage medium outside of the cartridge.", "18.The system of claim 15, further including a valve is configured to control the flow of beverage through a nozzle incorporated into the cartridge mixes the precursor liquid and beverage medium to aerate the beverage as the beverage flows.", "19.The system of claim 15, wherein the precursor liquid is cooled prior to dissolving carbon dioxide into the precursor liquid.", "20.The system of claim 15, wherein the precursor liquid is cooled after dissolving carbon dioxide into the precursor liquid." ], [ "<SOH> BACKGROUND <EOH>The inventions described herein relate to dissolving gas in liquids, e.g., carbonation, for use in preparing a beverage.", "Systems for carbonating liquids and/or mixing liquids with a beverage medium to form a beverage are described in a wide variety of publications, including U.S. Pat.", "Nos.", "4,025,655, 4,040,342; 4,636,337; 6,712,342 and 5,182,084; and PCT Publication WO 2008/124851." ], [ "<SOH> SUMMARY OF INVENTION <EOH>Aspects of the invention relate to carbonating or otherwise dissolving a gas in a precursor liquid, such as water, to form a beverage.", "In some embodiments, a carbon dioxide or other gas source can be provided in a cartridge which is used to generate carbon dioxide or other gas that is dissolved into the precursor liquid.", "A beverage medium, such as a powdered drink mix or liquid syrup, may be provided in the same, or a separate cartridge as the gas source and mixed with the precursor liquid (either before or after carbonation) to form a beverage.", "The use of one or more cartridges for the gas source and/or beverage medium may make for an easy to use and mess-free system for making carbonated or other sparkling beverages, e.g., in the consumer's home.", "(The term “carbonation” or “carbonated” is used herein to generically refer to beverages that have a dissolved gas, and thus refers to a sparkling beverage whether the dissolved gas is carbon dioxide, nitrogen, oxygen, air or other gas.", "Thus, aspects of the invention are not limited to forming beverages that have a dissolved carbon dioxide content, but rather may include any dissolved gas.)", "In one aspect of the invention a beverage making system includes a beverage precursor liquid supply arranged to provide a precursor liquid.", "The precursor liquid supply may include a reservoir, a pump, one or more conduits, one or more valves, one or more sensors (e.g., to detect a water level in the reservoir), and/or any other suitable components to provide water or other precursor liquid in a way suitable to form a beverage.", "The system may also include a single cartridge having first and/or second cartridge portions.", "The first cartridge portion may contain a gas source arranged to emit gas for use in dissolving into the precursor liquid, e.g., for carbonating the precursor liquid, and the second cartridge portion may contain a beverage medium arranged to be mixed with a liquid precursor to form a beverage.", "The system may include a cartridge interface, such as a chamber that receives and at least partially encloses the cartridge, a connection port arranged to fluidly couple with the cartridge, or other arrangement.", "A gas dissolution device may be arranged to dissolve gas that is emitted from the first cartridge portion into the precursor liquid, and may include, for example, a membrane contactor, a chamber suitable to hold a liquid under pressure to help dissolve gas in the liquid, a sparger, a sprinkler arranged to introduce water to a pressurized gas environment, or other arrangement.", "The system may be arranged to mix precursor liquid with the beverage medium, whether before or after gas is dissolved in the liquid, to form a beverage.", "The beverage medium may be mixed with the liquid in the cartridge, in another portion of the system such as a mixing chamber into which beverage medium from the cartridge is introduced along with precursor liquid, in a user's cup, or elsewhere.", "In one aspect of the invention, a beverage making system includes a beverage precursor liquid supply arranged to provide a precursor liquid, and a cartridge chamber arranged to hold first and/or second cartridge portions.", "The cartridge chamber may have a single cartridge receiving portion for receiving one or more cartridges, or may include a plurality of cartridge receiving portions that are separated from each other, e.g., for receiving two or more cartridges.", "Ifmultiple receiving portions are provided, they may be opened and closed simultaneously or independently of each other.", "A first cartridge portion may be provided in the cartridge chamber where the first cartridge portion contains a gas source arranged to emit carbon dioxide or other gas for use in carbonating the precursor liquid.", "In some embodiments, the gas source may include a charged molecular sieve, such as a zeolite that is in solid form (e.g., pellets) and has adsorbed carbon dioxide or other gas, that releases gas in the presence of water.", "A second cartridge portion may be provided in the cartridge chamber where the second cartridge portion contains a beverage medium arranged to be mixed with a liquid precursor to form a beverage.", "The system may be arranged to carbonate the precursor liquid using the gas emitted by the first cartridge portion and to mix the beverage medium of the second cartridge portion with the precursor liquid.", "The precursor liquid may be carbonated in the first cartridge portion, or in one or more other areas (such as a reservoir or membrane carbonator) to which gas is delivered.", "Mixing of the precursor liquid with beverage medium may occur before or after carbonation, and may occur in the second cartridge portion or in another location, such as a mixing chamber separate from the second cartridge portion.", "The system may include a gas source activating fluid supply arranged to provide fluid to the cartridge chamber for contact with the gas source to cause the gas source to emit gas.", "For example, the gas activating fluid supply may be arranged to control an amount of fluid (such as water in liquid or vapor form) provided to the cartridge chamber to control an amount of gas produced by the gas source.", "This may allow the system to control a gas pressure used to carbonate the precursor liquid.", "Thus, the cartridge chamber may be arranged to hold at least the first cartridge portion in the cartridge chamber under a pressure that is greater than an ambient pressure.", "Alternately, the first cartridge portion may be arranged to withstand a pressure caused by gas emitted by the gas source without a supporting structure or other enclosure.", "A gas supply may be arranged to conduct gas emitted by the gas source, under pressure greater than the ambient pressure, to beverage precursor liquid to carbonate the precursor liquid.", "The gas may be conducted to a carbonation tank, a membrane contactor, or other suitable arrangement for carbonation.", "For example, the system may include a carbonator that includes a membrane that separates a liquid side from a gas side of the carbonator, where the gas is provided to the gas side and the beverage precursor liquid supply provides precursor liquid to the liquid side such that gas on the gas side is dissolved in the precursor liquid on the liquid side.", "A pump may move precursor liquid from a reservoir through the carbonator for subsequent discharge as a beverage, or the precursor liquid may be circulated back to the reservoir for one or more additional passes through the carbonator.", "In some embodiments, the system may mix the beverage medium with precursor liquid to form a beverage such that none of the beverage contacts the gas source.", "However, in other embodiments, the precursor liquid may contact the gas source, e.g., where the liquid is passed through the first cartridge portion to be carbonated.", "The first and second cartridge portions may each be part of respective first and second cartridges that are distinct from each other, or the cartridge portions may be part of a single cartridge.", "Ifpart of a single cartridge, the first and second cartridge portions may be separated from each other, e.g., by a permeable element such as a filter, or an impermeable element such as a wall of the cartridge that may or may not be frangible, burstable (such as by suitable pressure), piercable or otherwise breached to allow the first and second cartridge portions to communicate with each other.", "A cartridge associated with the first and second cartridge portions may be pierced or otherwise arranged for fluid communication while in the cartridge chamber to allow access to the first and second portions.", "For example, if the cartridge portions are in separate cartridges, the two cartridges may be pierced by closing of the cartridge chamber to allow fluid to be provided to and/or gas to exit from the first cartridge portion, and to allow the beverage medium to exit the second cartridge portion whether alone or with a mixed precursor liquid.", "In some embodiments, the first and cartridge portions may each have a volume that is less than a volume of carbonated beverage to be formed using the cartridge portions.", "This can provide a significant advantage by allowing a user to form a relatively large volume beverage using a relative small volume cartridge or cartridges.", "For example, the system may be arranged to use the first and second cartridge portions over a period of time less than about 120 seconds to form a carbonated liquid having a volume of between 100-1000 ml and a carbonation level of about 1 to 5 volumes.", "Carbonation may occur at pressures between 20-50 psi, or more.", "The cartridge portions in this embodiment may have a volume of about 50 ml or less, reducing an amount of waste and/or adding to convenience of the system.", "In another aspect of the invention, a method for forming a beverage includes providing first and second cartridge portions to a beverage making machine where the first cartridge portion contains a gas source arranged to emit gas for use in carbonating a liquid, and the second cartridge portion contains a beverage medium arranged to be mixed with a liquid precursor to form a beverage.", "A fluid, such as water in liquid or vapor form, may be provided to the cartridge chamber to cause the gas source to emit gas, and a precursor liquid may be carbonated by dissolving at least a portion of the gas emitted from the gas source in the precursor liquid.", "The precursor liquid may be mixed with a beverage medium to produce a beverage, either before or after carbonation.", "As noted above, the gas source may be in solid form in the first cartridge portion, e.g., including a charged zeolite.", "An amount of fluid provided to the first cartridge portion may be controlled to control gas production by the gas source, e.g., to maintain a pressure of gas produced by the gas source to be within a desired range above an ambient pressure.", "In one embodiment, the gas source includes a charged zeolite, and an amount of fluid provided to the cartridge chamber is controlled so as to cause the charged zeolite to emit gas over a period of at least 30 seconds or more.", "Carbonation of the precursor liquid may include providing gas to a reservoir that contains precursor liquid, providing gas to a gas side of a membrane such that gas on the gas side is dissolved in the precursor liquid on a liquid side of the membrane, spraying precursor liquid in a gas-filled space, passing the precursor liquid through the first cartridge portion under pressure, and so on.", "As mentioned above, the first and second cartridge portions may each be part of respective first and second cartridges that are distinct from each other, or the cartridge portions may be part of a single cartridge.", "Ifpart of a single cartridge, the first and second cartridge portions may be separated from each other, e.g., by a cartridge wall.", "Mixing of the precursor liquid may occur before or after carbonation, and may occur in the second cartridge portion or in another location, such as a mixing chamber separate from the second cartridge portion.", "In one embodiment, the steps of providing a fluid and carbonating may be performed over a period of time less than about 120 seconds (e.g., about 60 seconds) and using a gas pressure of 20-50 psi (e.g., above ambient) to form a carbonated liquid having a volume of between 100-1000 ml (e.g., about 500 ml) and a carbonation level of about 2 to 4 volumes (or less or more, such as 1 to 5 volumes).", "Thus, systems and methods according to this aspect may produce a relatively highly carbonated beverage in a relatively short period of time, and without requiring high pressures.", "In another aspect of the invention, a beverage making system includes a beverage precursor liquid supply for providing a precursor liquid, a cartridge chamber or other interface arranged to hold a cartridge, and a cartridge including an internal space containing a gas source.", "The gas source may be arranged to emit gas for use in carbonating the precursor liquid, e.g., in response to contact with a fluid, such as water or other activating agent.", "A gas activating fluid supply may be arranged to provide fluid to the cartridge chamber for contact with the gas source to cause the gas source to emit gas, and the activating fluid supply may be arranged to control an amount of fluid provided to the cartridge chamber to control an amount of gas emitted by the gas source, e.g., to control a pressure in the cartridge chamber or other area.", "A gas supply may be arranged to conduct gas emitted by the gas source, under pressure greater than the ambient pressure, to precursor liquid provided via the beverage precursor liquid supply to carbonate the precursor liquid.", "The ability to control gas production, and thus pressure, in a relatively simple way of controlling fluid flow into the cartridge chamber, may provide advantages of a simple control and system operation.", "The beverage precursor liquid supply may include a reservoir that contains precursor liquid, a carbonator that includes a membrane that separates a liquid side from a gas side of the carbonator, a pump that moves precursor liquid from the reservoir through the carbonator or other portion of the system, one or more filters or other liquid treatment devices, and so on.", "The cartridge chamber may be arranged to hold the cartridge in the chamber under a pressure that is greater than an ambient pressure, e.g., within a pressure range that is suitable for carbonating the precursor liquid.", "In some embodiments, gas pressure used for carbonation may be between about 20 and 50 psi, although higher (and lower) pressures are possible.", "In another aspect of the invention, a method for forming a beverage includes providing a cartridge having an internal space that is sealed to enclose a gas source in the internal space, providing fluid to the cartridge to cause the gas source to emit gas, controlling an amount of fluid provided to the cartridge over a period of time to control an amount of gas emitted by the gas source during the period of time, and carbonating a precursor liquid by dissolving at least a portion of the gas emitted from the gas source in the precursor liquid.", "The precursor liquid may be mixed with a beverage medium to produce a beverage, either before or after carbonation, whether in a cartridge or other area.", "In one embodiment, the cartridge may be pierced using a beverage making machine to provide liquid to the cartridge, while in other embodiments liquid may be provided to the cartridge via a defined port or other arrangement.", "As with the embodiments above, the liquid may be carbonated in the cartridge or other area, such as a carbonator or reservoir, the cartridge may include a second portion that includes the beverage medium (or a second cartridge may be used with the beverage medium), and so on.", "In another aspect of the invention, a method for forming a carbonated beverage includes providing a cartridge having an internal space that is sealed to enclose a gas source in the internal space where the gas source is in solid form, opening the cartridge (such as by piercing) and causing the gas source to emit gas, and carbonating a liquid by dissolving at least a portion of the gas emitted from the gas source in the liquid.", "The liquid may be mixed with a beverage medium by passing the liquid through a cartridge chamber that contains the beverage medium to produce a beverage.", "By mixing the liquid with beverage medium in a 30 cartridge, the need for a separate mixing chamber may be avoided, and flavor contamination between consecutively made beverages may be reduced (because the cartridge serves as the mixing chamber and is used only once).", "In one embodiment, the cartridge that encloses the gas source also includes the cartridge chamber that contains the beverage medium.", "For example, liquid may be introduced into a first portion of the cartridge where the gas source is located for carbonation, and pass from the first portion to a second portion where the beverage medium is located.", "In another embodiment, the cartridge chamber where liquid is mixed with beverage medium may be part of a second cartridge separate from the cartridge that encloses the gas source.", "Gas from the cartridge may be routed to an area where the gas is dissolved in the liquid, e.g., to a membrane contactor, a reservoir that holds a substantial portion of the liquid, or other arrangement.", "A pressure of the gas may be controlled by controlling an amount of fluid provided to the cartridge.", "As with other aspects of the invention, various embodiments and optional features described herein may be used with this aspect of the invention.", "In another aspect of the invention, a kit for forming a beverage includes a first cartridge having an internal space that is sealed and contains a gas source in the internal space.", "The gas source may be in solid form, or stored in the internal space at pressures below 100 psi, and arranged to emit gas for use in carbonating a precursor liquid.", "The first cartridge may be arranged to have an inlet through which fluid is provided to activate the gas source and an outlet through which gas exits the first cartridge.", "For example, the first cartridge may be pierced to form the inlet and outlet, or the first cartridge may have a defined inlet/outlet.", "A second cartridge of the kit may include an internal space that is sealed and contains a beverage medium for use in mixing with the precursor liquid to form a beverage.", "The second cartridge may be arranged to mix a precursor liquid with the beverage medium in the second cartridge, and thus may be pierceable or otherwise arranged to allow inlet of liquid and outlet of mixed liquid/beverage medium.", "The first and second cartridges may each have a volume that is less than a volume of beverage to be formed using the first and second cartridges, e.g., the cartridge may have a volume of about 50 ml and be used to make a beverage having a volume of about 500 ml.", "The first and second cartridges may be joined together, e.g., such that the cartridges cannot be separated from each other, without use of tools, without damaging at least a portion of the first or second cartridge.", "In one embodiment, the first and second cartridges may be joined by a welded joint or by interlocking mechanical fasteners.", "In another aspect of the invention, a cartridge for forming a beverage includes a container having an internal space that is sealed and contains a gas source in the internal space.", "The gas source may be in solid form (such as a charged zeolite or other molecular sieve) and arranged to emit gas for use in carbonating a precursor liquid.", "In one arrangement, the gas or other gas source may be stored in a sealed space in the cartridge for an extended period at a pressure of less than about 100 psi prior to the sealed space being opened.", "Thus, the cartridge need not necessarily be capable of withstanding high pressures to store the gas source.", "The container may be arranged to have an inlet through which fluid is provided to activate the gas source and an outlet through which gas exits the container for use in carbonating the precursor liquid.", "In one embodiment, the container may be pierceable by a beverage making machine to form the inlet and to form the outlet, e.g., at the top, bottom, side and/or other locations of the cartridge.", "In one arrangement, the container may include a lid that is pierceable by a beverage machine to form both the inlet and outlet.", "The container may have at least one portion that is semi-rigid or flexible, e.g., that is not suitable to withstand a pressure over about 80 psi inside the cartridge without physical support.", "The container may include a second chamber that contains a beverage medium for use in flavoring the precursor liquid to form a beverage, and the second chamber may be isolated from a first chamber in which the gas source is contained.", "The container may have a volume that is less than a volume of carbonated beverage to be formed using the cartridge.", "In another aspect of the invention, a beverage making system includes a cartridge chamber arranged to hold a cartridge under a pressure that is greater than an ambient pressure, and a cartridge including an internal space containing a gas source arranged to emit gas for use in carbonating a liquid.", "The cartridge may have a volume that is less than a volume of beverage to be created using the cartridge, e.g., a volume of 50 ml or less for use in carbonating a volume of liquid of about 100-1000 ml to a carbonation level of at least about 1 to 4 volumes.", "A beverage precursor liquid supply may provide precursor liquid into the internal space of the cartridge to cause the gas source to emit gas and cause at least some of the gas to be dissolved in the precursor liquid while in the internal space.", "Carbonating the liquid in a cartridge chamber can simplify system operation, e.g., by eliminating the need for carbonation tanks or other carbonators.", "Instead, the cartridge may function as a carbonator, at least in part.", "In one embodiment, the cartridge includes a second chamber that contains a beverage medium for use in mixing with the precursor liquid to form a beverage.", "The second chamber may be isolated from a first chamber in which the gas source is contained, or the first and second chamber may communicate, e.g., liquid may be introduced into the first chamber to be carbonated and pass from the first chamber to the second chamber where the beverage medium is located.", "In another aspect of the invention, a method for forming a beverage includes providing a cartridge having an internal space that is sealed to enclose a gas source in the internal space where the cartridge has a volume that is less than a volume of beverage to be created using the cartridge.", "Liquid may be provided into the cartridge to cause the gas source to emit gas, and the liquid may be carbonated by dissolving at least a portion of the gas emitted from the gas source in the liquid while the liquid is in the cartridge.", "The liquid may be mixed with a beverage medium to produce a beverage, either before or after carbonation in the cartridge.", "In fact, the cartridge may include a second chamber that contains a beverage medium for use in mixing with the precursor liquid to form a beverage, and the cartridge may have a volume that is less than a beverage to be made using the cartridge.", "The cartridge may be pierced using a beverage making machine to form an inlet and an outlet.", "In another aspect of the invention, a beverage making system includes a beverage precursor liquid supply, a cartridge chamber or other interface arranged to hold a cartridge in a chamber, and a cartridge including an internal space containing a gas source that is in solid form and is arranged to emit gas for use in carbonating a liquid.", "A gas activating fluid supply may provide liquid to the cartridge for contact with the gas source to cause the gas source to emit gas.", "The system may also include a carbonator that has a membrane that separates a liquid side from a gas side, where the gas emitted by the cartridge is provided to the gas side and the beverage precursor liquid supply provides precursor liquid to the liquid side such that gas on the gas side is dissolved in the precursor liquid on the liquid side.", "The cartridge interface may be arranged to hold the cartridge in the chamber under a pressure that is greater than an ambient pressure, e.g., within a pressure range used to carbonate the liquid in the carbonator.", "A gas supply may be arranged to conduct gas emitted by the gas source, under pressure greater than the ambient pressure, from the cartridge chamber to the gas side of the carbonator.", "The membrane of the carbonator may include a plurality of hollow fibers where an interior of the hollow fibers is part of the liquid side and an exterior of the hollow fibers is part of the gas side.", "In another aspect of the invention, a method for forming a beverage includes providing a cartridge having an internal space that is sealed to enclose a gas source in the internal space that is in solid form and arranged to emit gas, opening or otherwise accessing the cartridge (such as by piercing) and causing the cartridge to emit gas, and carbonating the liquid by dissolving at least a portion of the gas emitted from the gas source in a liquid.", "The gas may be located on a gas side of a membrane and the liquid being located on a liquid side of the membrane.", "The membrane may be formed by a plurality of hollow fibers where the liquid side is located at an interior of the fibers and the gas side is at an exterior of the fibers.", "A gas pressure at the gas side may be controlled based on controlling an amount of liquid provided to the cartridge.", "In another embodiment, a cartridge for use by a beverage making machine in forming a beverage includes first and second portions that are attached together and separated by an impermeable barrier, such as a lid or other container part of the first and/or second portion.", "The first portion may contain a gas source for emitting a gas to be dissolved in a beverage precursor liquid, and the second portion may contain a beverage medium for mixing with a precursor liquid to form a beverage.", "The first and second portions may be arranged with respect to each other so that the cartridge has a plane where the first portion is located below the plane and the second portion is located above the plane.", "For example, the second portion may be stacked on top of the first portion, e.g., with lids of the first and second portions located adjacent each other.", "In one illustrative embodiment, a cartridge for use by a beverage making machine in forming a beverage includes a container with first and second portions that are attached together and separated by an impermeable barrier, such as a foil lid used to close a container part of the first and/or second portion.", "The first portion may contain a gas source for emitting a gas to be dissolved in a beverage precursor liquid, and the second portion may contain a beverage medium for mixing with a precursor liquid to form a beverage.", "The second portion may include a wall, such as a lid, a sidewall of a container part, a bottom of a container part, a wall of a bag, etc., that is movable to force beverage medium to exit the second portion for mixing with precursor liquid.", "The wall may be movable in any suitable way, such as by air or other gas pressure, a plunger, piston or other item contacting and moving the wall, and so on.", "In the embodiments above, the first portion may have an inlet through which fluid is provided to activate the gas source (e.g., a lid or other part of the first portion may be pierced to form an inlet opening) and an outlet through which gas exits the first portion for dissolving in the precursor liquid (e.g., a lid or other part of the first portion may be pierced to form an outlet opening).", "The inlet and outlet may be located on a same side of the first portion, such as a top of the first portion.", "In one arrangement, the first portion may include a surface arranged to accommodate piercing to form an inlet through which fluid is provided to activate the gas source, and the first portion may be attached to the second portion such that the surface is unexposed.", "For example, the second portion may be attached to the first portion so that the piercable part of the first portion is covered by the second portion.", "This arrangement may help reduce the likelihood that the surface is prematurely pierced, e.g., pierced by accident prior to the cartridge being associated with a beverage making machine.", "The second portion may have an outlet through which the beverage medium exits the container for mixing with the precursor liquid, e.g., a part of the second portion may be pierced to form an opening for beverage medium exit, the second portion may have a frangible seal or other element that opens to release beverage medium, etc.", "In one embodiment, the movable wall defines, at least in part, the first portion of the cartridge.", "For example, the first portion may be defined at least in part by a first chamber wall, and the second portion may be defined at least in part by a second chamber wall that defines a second space.", "The first chamber wall may be received into the second space, e.g., like a plunger, and be movable relative to the second chamber wall to expel beverage medium from the second portion of the cartridge.", "In some embodiments, the wall may include a layer of barrier material, such as a metal foil, a metal foil/polymer laminate, a layer of plastic material, etc.", "For example, the second portion may be defined by a capsule formed by a layer a metal foil material, such as a sheet aluminum.", "The layer of barrier material may be arranged to open (e.g., by bursting or piercing) and allow beverage medium to exit the second portion when a force is applied to the barrier material.", "For example, the cartridge may include a piercing element that opens the second portion when a force is applied to the barrier material.", "In another embodiment, the wall includes corrugations and a frangible outlet that is openable based on pressure inside the second portion.", "The wall may be pressed so that the corrugations collapse, e.g., in a staged or sequential fashion, to force beverage medium through the outlet, which may include a burstable seal formed by a weakened portion of the wall (e.g., by scoring, partial perforation, etc.).", "Like the second portion, the first portion may be defined by a capsule formed by a layer of barrier material, and the first and second portions may be attached together, e.g., by crimping rims or edges of the barrier material together.", "The first and second portions may be sealed from an exterior environment and the first portion may contain a carbon dioxide source in solid form (such as a charged zeolite) arranged to emit carbon dioxide gas for use in mixing with a beverage precursor liquid to form a beverage.", "In one embodiment, a pressure in the first portion prior to breaking a seal of the first portion to expose the gas source may be relatively low, e.g., less than 100 psi.", "However, the gas source may be arranged to emit gas suitable for forming a carbonated beverage having a volume of between 100-1000 ml and a carbonation level of about 1 to 5.These and other aspects of the invention will be apparent from the following description and claims." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a divisional of U.S. patent application Ser.", "No.", "14/445,571, filed Jul.", "29, 2014, which is a continuation of U.S. patent application Ser.", "No.", "13/565,214, filed Aug. 2, 2012, which claims the benefit of U.S.", "Provisional Application No.", "61/514,676, filed Aug. 3, 2011, the contents of each of which is hereby incorporated by reference in its entirety.", "U.S. patent application Ser.", "No.", "13/565,214 is also a continuation-in-part of U.S. application Ser.", "No.", "13/017,459, filed Jan. 31, 2011, which claims the benefit of U.S.", "Provisional Application No.", "61/337,184, filed Feb. 1, 2010.BACKGROUND The inventions described herein relate to dissolving gas in liquids, e.g., carbonation, for use in preparing a beverage.", "Systems for carbonating liquids and/or mixing liquids with a beverage medium to form a beverage are described in a wide variety of publications, including U.S. Pat.", "Nos.", "4,025,655, 4,040,342; 4,636,337; 6,712,342 and 5,182,084; and PCT Publication WO 2008/124851.SUMMARY OF INVENTION Aspects of the invention relate to carbonating or otherwise dissolving a gas in a precursor liquid, such as water, to form a beverage.", "In some embodiments, a carbon dioxide or other gas source can be provided in a cartridge which is used to generate carbon dioxide or other gas that is dissolved into the precursor liquid.", "A beverage medium, such as a powdered drink mix or liquid syrup, may be provided in the same, or a separate cartridge as the gas source and mixed with the precursor liquid (either before or after carbonation) to form a beverage.", "The use of one or more cartridges for the gas source and/or beverage medium may make for an easy to use and mess-free system for making carbonated or other sparkling beverages, e.g., in the consumer's home.", "(The term “carbonation” or “carbonated” is used herein to generically refer to beverages that have a dissolved gas, and thus refers to a sparkling beverage whether the dissolved gas is carbon dioxide, nitrogen, oxygen, air or other gas.", "Thus, aspects of the invention are not limited to forming beverages that have a dissolved carbon dioxide content, but rather may include any dissolved gas.)", "In one aspect of the invention a beverage making system includes a beverage precursor liquid supply arranged to provide a precursor liquid.", "The precursor liquid supply may include a reservoir, a pump, one or more conduits, one or more valves, one or more sensors (e.g., to detect a water level in the reservoir), and/or any other suitable components to provide water or other precursor liquid in a way suitable to form a beverage.", "The system may also include a single cartridge having first and/or second cartridge portions.", "The first cartridge portion may contain a gas source arranged to emit gas for use in dissolving into the precursor liquid, e.g., for carbonating the precursor liquid, and the second cartridge portion may contain a beverage medium arranged to be mixed with a liquid precursor to form a beverage.", "The system may include a cartridge interface, such as a chamber that receives and at least partially encloses the cartridge, a connection port arranged to fluidly couple with the cartridge, or other arrangement.", "A gas dissolution device may be arranged to dissolve gas that is emitted from the first cartridge portion into the precursor liquid, and may include, for example, a membrane contactor, a chamber suitable to hold a liquid under pressure to help dissolve gas in the liquid, a sparger, a sprinkler arranged to introduce water to a pressurized gas environment, or other arrangement.", "The system may be arranged to mix precursor liquid with the beverage medium, whether before or after gas is dissolved in the liquid, to form a beverage.", "The beverage medium may be mixed with the liquid in the cartridge, in another portion of the system such as a mixing chamber into which beverage medium from the cartridge is introduced along with precursor liquid, in a user's cup, or elsewhere.", "In one aspect of the invention, a beverage making system includes a beverage precursor liquid supply arranged to provide a precursor liquid, and a cartridge chamber arranged to hold first and/or second cartridge portions.", "The cartridge chamber may have a single cartridge receiving portion for receiving one or more cartridges, or may include a plurality of cartridge receiving portions that are separated from each other, e.g., for receiving two or more cartridges.", "Ifmultiple receiving portions are provided, they may be opened and closed simultaneously or independently of each other.", "A first cartridge portion may be provided in the cartridge chamber where the first cartridge portion contains a gas source arranged to emit carbon dioxide or other gas for use in carbonating the precursor liquid.", "In some embodiments, the gas source may include a charged molecular sieve, such as a zeolite that is in solid form (e.g., pellets) and has adsorbed carbon dioxide or other gas, that releases gas in the presence of water.", "A second cartridge portion may be provided in the cartridge chamber where the second cartridge portion contains a beverage medium arranged to be mixed with a liquid precursor to form a beverage.", "The system may be arranged to carbonate the precursor liquid using the gas emitted by the first cartridge portion and to mix the beverage medium of the second cartridge portion with the precursor liquid.", "The precursor liquid may be carbonated in the first cartridge portion, or in one or more other areas (such as a reservoir or membrane carbonator) to which gas is delivered.", "Mixing of the precursor liquid with beverage medium may occur before or after carbonation, and may occur in the second cartridge portion or in another location, such as a mixing chamber separate from the second cartridge portion.", "The system may include a gas source activating fluid supply arranged to provide fluid to the cartridge chamber for contact with the gas source to cause the gas source to emit gas.", "For example, the gas activating fluid supply may be arranged to control an amount of fluid (such as water in liquid or vapor form) provided to the cartridge chamber to control an amount of gas produced by the gas source.", "This may allow the system to control a gas pressure used to carbonate the precursor liquid.", "Thus, the cartridge chamber may be arranged to hold at least the first cartridge portion in the cartridge chamber under a pressure that is greater than an ambient pressure.", "Alternately, the first cartridge portion may be arranged to withstand a pressure caused by gas emitted by the gas source without a supporting structure or other enclosure.", "A gas supply may be arranged to conduct gas emitted by the gas source, under pressure greater than the ambient pressure, to beverage precursor liquid to carbonate the precursor liquid.", "The gas may be conducted to a carbonation tank, a membrane contactor, or other suitable arrangement for carbonation.", "For example, the system may include a carbonator that includes a membrane that separates a liquid side from a gas side of the carbonator, where the gas is provided to the gas side and the beverage precursor liquid supply provides precursor liquid to the liquid side such that gas on the gas side is dissolved in the precursor liquid on the liquid side.", "A pump may move precursor liquid from a reservoir through the carbonator for subsequent discharge as a beverage, or the precursor liquid may be circulated back to the reservoir for one or more additional passes through the carbonator.", "In some embodiments, the system may mix the beverage medium with precursor liquid to form a beverage such that none of the beverage contacts the gas source.", "However, in other embodiments, the precursor liquid may contact the gas source, e.g., where the liquid is passed through the first cartridge portion to be carbonated.", "The first and second cartridge portions may each be part of respective first and second cartridges that are distinct from each other, or the cartridge portions may be part of a single cartridge.", "Ifpart of a single cartridge, the first and second cartridge portions may be separated from each other, e.g., by a permeable element such as a filter, or an impermeable element such as a wall of the cartridge that may or may not be frangible, burstable (such as by suitable pressure), piercable or otherwise breached to allow the first and second cartridge portions to communicate with each other.", "A cartridge associated with the first and second cartridge portions may be pierced or otherwise arranged for fluid communication while in the cartridge chamber to allow access to the first and second portions.", "For example, if the cartridge portions are in separate cartridges, the two cartridges may be pierced by closing of the cartridge chamber to allow fluid to be provided to and/or gas to exit from the first cartridge portion, and to allow the beverage medium to exit the second cartridge portion whether alone or with a mixed precursor liquid.", "In some embodiments, the first and cartridge portions may each have a volume that is less than a volume of carbonated beverage to be formed using the cartridge portions.", "This can provide a significant advantage by allowing a user to form a relatively large volume beverage using a relative small volume cartridge or cartridges.", "For example, the system may be arranged to use the first and second cartridge portions over a period of time less than about 120 seconds to form a carbonated liquid having a volume of between 100-1000 ml and a carbonation level of about 1 to 5 volumes.", "Carbonation may occur at pressures between 20-50 psi, or more.", "The cartridge portions in this embodiment may have a volume of about 50 ml or less, reducing an amount of waste and/or adding to convenience of the system.", "In another aspect of the invention, a method for forming a beverage includes providing first and second cartridge portions to a beverage making machine where the first cartridge portion contains a gas source arranged to emit gas for use in carbonating a liquid, and the second cartridge portion contains a beverage medium arranged to be mixed with a liquid precursor to form a beverage.", "A fluid, such as water in liquid or vapor form, may be provided to the cartridge chamber to cause the gas source to emit gas, and a precursor liquid may be carbonated by dissolving at least a portion of the gas emitted from the gas source in the precursor liquid.", "The precursor liquid may be mixed with a beverage medium to produce a beverage, either before or after carbonation.", "As noted above, the gas source may be in solid form in the first cartridge portion, e.g., including a charged zeolite.", "An amount of fluid provided to the first cartridge portion may be controlled to control gas production by the gas source, e.g., to maintain a pressure of gas produced by the gas source to be within a desired range above an ambient pressure.", "In one embodiment, the gas source includes a charged zeolite, and an amount of fluid provided to the cartridge chamber is controlled so as to cause the charged zeolite to emit gas over a period of at least 30 seconds or more.", "Carbonation of the precursor liquid may include providing gas to a reservoir that contains precursor liquid, providing gas to a gas side of a membrane such that gas on the gas side is dissolved in the precursor liquid on a liquid side of the membrane, spraying precursor liquid in a gas-filled space, passing the precursor liquid through the first cartridge portion under pressure, and so on.", "As mentioned above, the first and second cartridge portions may each be part of respective first and second cartridges that are distinct from each other, or the cartridge portions may be part of a single cartridge.", "Ifpart of a single cartridge, the first and second cartridge portions may be separated from each other, e.g., by a cartridge wall.", "Mixing of the precursor liquid may occur before or after carbonation, and may occur in the second cartridge portion or in another location, such as a mixing chamber separate from the second cartridge portion.", "In one embodiment, the steps of providing a fluid and carbonating may be performed over a period of time less than about 120 seconds (e.g., about 60 seconds) and using a gas pressure of 20-50 psi (e.g., above ambient) to form a carbonated liquid having a volume of between 100-1000 ml (e.g., about 500 ml) and a carbonation level of about 2 to 4 volumes (or less or more, such as 1 to 5 volumes).", "Thus, systems and methods according to this aspect may produce a relatively highly carbonated beverage in a relatively short period of time, and without requiring high pressures.", "In another aspect of the invention, a beverage making system includes a beverage precursor liquid supply for providing a precursor liquid, a cartridge chamber or other interface arranged to hold a cartridge, and a cartridge including an internal space containing a gas source.", "The gas source may be arranged to emit gas for use in carbonating the precursor liquid, e.g., in response to contact with a fluid, such as water or other activating agent.", "A gas activating fluid supply may be arranged to provide fluid to the cartridge chamber for contact with the gas source to cause the gas source to emit gas, and the activating fluid supply may be arranged to control an amount of fluid provided to the cartridge chamber to control an amount of gas emitted by the gas source, e.g., to control a pressure in the cartridge chamber or other area.", "A gas supply may be arranged to conduct gas emitted by the gas source, under pressure greater than the ambient pressure, to precursor liquid provided via the beverage precursor liquid supply to carbonate the precursor liquid.", "The ability to control gas production, and thus pressure, in a relatively simple way of controlling fluid flow into the cartridge chamber, may provide advantages of a simple control and system operation.", "The beverage precursor liquid supply may include a reservoir that contains precursor liquid, a carbonator that includes a membrane that separates a liquid side from a gas side of the carbonator, a pump that moves precursor liquid from the reservoir through the carbonator or other portion of the system, one or more filters or other liquid treatment devices, and so on.", "The cartridge chamber may be arranged to hold the cartridge in the chamber under a pressure that is greater than an ambient pressure, e.g., within a pressure range that is suitable for carbonating the precursor liquid.", "In some embodiments, gas pressure used for carbonation may be between about 20 and 50 psi, although higher (and lower) pressures are possible.", "In another aspect of the invention, a method for forming a beverage includes providing a cartridge having an internal space that is sealed to enclose a gas source in the internal space, providing fluid to the cartridge to cause the gas source to emit gas, controlling an amount of fluid provided to the cartridge over a period of time to control an amount of gas emitted by the gas source during the period of time, and carbonating a precursor liquid by dissolving at least a portion of the gas emitted from the gas source in the precursor liquid.", "The precursor liquid may be mixed with a beverage medium to produce a beverage, either before or after carbonation, whether in a cartridge or other area.", "In one embodiment, the cartridge may be pierced using a beverage making machine to provide liquid to the cartridge, while in other embodiments liquid may be provided to the cartridge via a defined port or other arrangement.", "As with the embodiments above, the liquid may be carbonated in the cartridge or other area, such as a carbonator or reservoir, the cartridge may include a second portion that includes the beverage medium (or a second cartridge may be used with the beverage medium), and so on.", "In another aspect of the invention, a method for forming a carbonated beverage includes providing a cartridge having an internal space that is sealed to enclose a gas source in the internal space where the gas source is in solid form, opening the cartridge (such as by piercing) and causing the gas source to emit gas, and carbonating a liquid by dissolving at least a portion of the gas emitted from the gas source in the liquid.", "The liquid may be mixed with a beverage medium by passing the liquid through a cartridge chamber that contains the beverage medium to produce a beverage.", "By mixing the liquid with beverage medium in a 30 cartridge, the need for a separate mixing chamber may be avoided, and flavor contamination between consecutively made beverages may be reduced (because the cartridge serves as the mixing chamber and is used only once).", "In one embodiment, the cartridge that encloses the gas source also includes the cartridge chamber that contains the beverage medium.", "For example, liquid may be introduced into a first portion of the cartridge where the gas source is located for carbonation, and pass from the first portion to a second portion where the beverage medium is located.", "In another embodiment, the cartridge chamber where liquid is mixed with beverage medium may be part of a second cartridge separate from the cartridge that encloses the gas source.", "Gas from the cartridge may be routed to an area where the gas is dissolved in the liquid, e.g., to a membrane contactor, a reservoir that holds a substantial portion of the liquid, or other arrangement.", "A pressure of the gas may be controlled by controlling an amount of fluid provided to the cartridge.", "As with other aspects of the invention, various embodiments and optional features described herein may be used with this aspect of the invention.", "In another aspect of the invention, a kit for forming a beverage includes a first cartridge having an internal space that is sealed and contains a gas source in the internal space.", "The gas source may be in solid form, or stored in the internal space at pressures below 100 psi, and arranged to emit gas for use in carbonating a precursor liquid.", "The first cartridge may be arranged to have an inlet through which fluid is provided to activate the gas source and an outlet through which gas exits the first cartridge.", "For example, the first cartridge may be pierced to form the inlet and outlet, or the first cartridge may have a defined inlet/outlet.", "A second cartridge of the kit may include an internal space that is sealed and contains a beverage medium for use in mixing with the precursor liquid to form a beverage.", "The second cartridge may be arranged to mix a precursor liquid with the beverage medium in the second cartridge, and thus may be pierceable or otherwise arranged to allow inlet of liquid and outlet of mixed liquid/beverage medium.", "The first and second cartridges may each have a volume that is less than a volume of beverage to be formed using the first and second cartridges, e.g., the cartridge may have a volume of about 50 ml and be used to make a beverage having a volume of about 500 ml.", "The first and second cartridges may be joined together, e.g., such that the cartridges cannot be separated from each other, without use of tools, without damaging at least a portion of the first or second cartridge.", "In one embodiment, the first and second cartridges may be joined by a welded joint or by interlocking mechanical fasteners.", "In another aspect of the invention, a cartridge for forming a beverage includes a container having an internal space that is sealed and contains a gas source in the internal space.", "The gas source may be in solid form (such as a charged zeolite or other molecular sieve) and arranged to emit gas for use in carbonating a precursor liquid.", "In one arrangement, the gas or other gas source may be stored in a sealed space in the cartridge for an extended period at a pressure of less than about 100 psi prior to the sealed space being opened.", "Thus, the cartridge need not necessarily be capable of withstanding high pressures to store the gas source.", "The container may be arranged to have an inlet through which fluid is provided to activate the gas source and an outlet through which gas exits the container for use in carbonating the precursor liquid.", "In one embodiment, the container may be pierceable by a beverage making machine to form the inlet and to form the outlet, e.g., at the top, bottom, side and/or other locations of the cartridge.", "In one arrangement, the container may include a lid that is pierceable by a beverage machine to form both the inlet and outlet.", "The container may have at least one portion that is semi-rigid or flexible, e.g., that is not suitable to withstand a pressure over about 80 psi inside the cartridge without physical support.", "The container may include a second chamber that contains a beverage medium for use in flavoring the precursor liquid to form a beverage, and the second chamber may be isolated from a first chamber in which the gas source is contained.", "The container may have a volume that is less than a volume of carbonated beverage to be formed using the cartridge.", "In another aspect of the invention, a beverage making system includes a cartridge chamber arranged to hold a cartridge under a pressure that is greater than an ambient pressure, and a cartridge including an internal space containing a gas source arranged to emit gas for use in carbonating a liquid.", "The cartridge may have a volume that is less than a volume of beverage to be created using the cartridge, e.g., a volume of 50 ml or less for use in carbonating a volume of liquid of about 100-1000 ml to a carbonation level of at least about 1 to 4 volumes.", "A beverage precursor liquid supply may provide precursor liquid into the internal space of the cartridge to cause the gas source to emit gas and cause at least some of the gas to be dissolved in the precursor liquid while in the internal space.", "Carbonating the liquid in a cartridge chamber can simplify system operation, e.g., by eliminating the need for carbonation tanks or other carbonators.", "Instead, the cartridge may function as a carbonator, at least in part.", "In one embodiment, the cartridge includes a second chamber that contains a beverage medium for use in mixing with the precursor liquid to form a beverage.", "The second chamber may be isolated from a first chamber in which the gas source is contained, or the first and second chamber may communicate, e.g., liquid may be introduced into the first chamber to be carbonated and pass from the first chamber to the second chamber where the beverage medium is located.", "In another aspect of the invention, a method for forming a beverage includes providing a cartridge having an internal space that is sealed to enclose a gas source in the internal space where the cartridge has a volume that is less than a volume of beverage to be created using the cartridge.", "Liquid may be provided into the cartridge to cause the gas source to emit gas, and the liquid may be carbonated by dissolving at least a portion of the gas emitted from the gas source in the liquid while the liquid is in the cartridge.", "The liquid may be mixed with a beverage medium to produce a beverage, either before or after carbonation in the cartridge.", "In fact, the cartridge may include a second chamber that contains a beverage medium for use in mixing with the precursor liquid to form a beverage, and the cartridge may have a volume that is less than a beverage to be made using the cartridge.", "The cartridge may be pierced using a beverage making machine to form an inlet and an outlet.", "In another aspect of the invention, a beverage making system includes a beverage precursor liquid supply, a cartridge chamber or other interface arranged to hold a cartridge in a chamber, and a cartridge including an internal space containing a gas source that is in solid form and is arranged to emit gas for use in carbonating a liquid.", "A gas activating fluid supply may provide liquid to the cartridge for contact with the gas source to cause the gas source to emit gas.", "The system may also include a carbonator that has a membrane that separates a liquid side from a gas side, where the gas emitted by the cartridge is provided to the gas side and the beverage precursor liquid supply provides precursor liquid to the liquid side such that gas on the gas side is dissolved in the precursor liquid on the liquid side.", "The cartridge interface may be arranged to hold the cartridge in the chamber under a pressure that is greater than an ambient pressure, e.g., within a pressure range used to carbonate the liquid in the carbonator.", "A gas supply may be arranged to conduct gas emitted by the gas source, under pressure greater than the ambient pressure, from the cartridge chamber to the gas side of the carbonator.", "The membrane of the carbonator may include a plurality of hollow fibers where an interior of the hollow fibers is part of the liquid side and an exterior of the hollow fibers is part of the gas side.", "In another aspect of the invention, a method for forming a beverage includes providing a cartridge having an internal space that is sealed to enclose a gas source in the internal space that is in solid form and arranged to emit gas, opening or otherwise accessing the cartridge (such as by piercing) and causing the cartridge to emit gas, and carbonating the liquid by dissolving at least a portion of the gas emitted from the gas source in a liquid.", "The gas may be located on a gas side of a membrane and the liquid being located on a liquid side of the membrane.", "The membrane may be formed by a plurality of hollow fibers where the liquid side is located at an interior of the fibers and the gas side is at an exterior of the fibers.", "A gas pressure at the gas side may be controlled based on controlling an amount of liquid provided to the cartridge.", "In another embodiment, a cartridge for use by a beverage making machine in forming a beverage includes first and second portions that are attached together and separated by an impermeable barrier, such as a lid or other container part of the first and/or second portion.", "The first portion may contain a gas source for emitting a gas to be dissolved in a beverage precursor liquid, and the second portion may contain a beverage medium for mixing with a precursor liquid to form a beverage.", "The first and second portions may be arranged with respect to each other so that the cartridge has a plane where the first portion is located below the plane and the second portion is located above the plane.", "For example, the second portion may be stacked on top of the first portion, e.g., with lids of the first and second portions located adjacent each other.", "In one illustrative embodiment, a cartridge for use by a beverage making machine in forming a beverage includes a container with first and second portions that are attached together and separated by an impermeable barrier, such as a foil lid used to close a container part of the first and/or second portion.", "The first portion may contain a gas source for emitting a gas to be dissolved in a beverage precursor liquid, and the second portion may contain a beverage medium for mixing with a precursor liquid to form a beverage.", "The second portion may include a wall, such as a lid, a sidewall of a container part, a bottom of a container part, a wall of a bag, etc., that is movable to force beverage medium to exit the second portion for mixing with precursor liquid.", "The wall may be movable in any suitable way, such as by air or other gas pressure, a plunger, piston or other item contacting and moving the wall, and so on.", "In the embodiments above, the first portion may have an inlet through which fluid is provided to activate the gas source (e.g., a lid or other part of the first portion may be pierced to form an inlet opening) and an outlet through which gas exits the first portion for dissolving in the precursor liquid (e.g., a lid or other part of the first portion may be pierced to form an outlet opening).", "The inlet and outlet may be located on a same side of the first portion, such as a top of the first portion.", "In one arrangement, the first portion may include a surface arranged to accommodate piercing to form an inlet through which fluid is provided to activate the gas source, and the first portion may be attached to the second portion such that the surface is unexposed.", "For example, the second portion may be attached to the first portion so that the piercable part of the first portion is covered by the second portion.", "This arrangement may help reduce the likelihood that the surface is prematurely pierced, e.g., pierced by accident prior to the cartridge being associated with a beverage making machine.", "The second portion may have an outlet through which the beverage medium exits the container for mixing with the precursor liquid, e.g., a part of the second portion may be pierced to form an opening for beverage medium exit, the second portion may have a frangible seal or other element that opens to release beverage medium, etc.", "In one embodiment, the movable wall defines, at least in part, the first portion of the cartridge.", "For example, the first portion may be defined at least in part by a first chamber wall, and the second portion may be defined at least in part by a second chamber wall that defines a second space.", "The first chamber wall may be received into the second space, e.g., like a plunger, and be movable relative to the second chamber wall to expel beverage medium from the second portion of the cartridge.", "In some embodiments, the wall may include a layer of barrier material, such as a metal foil, a metal foil/polymer laminate, a layer of plastic material, etc.", "For example, the second portion may be defined by a capsule formed by a layer a metal foil material, such as a sheet aluminum.", "The layer of barrier material may be arranged to open (e.g., by bursting or piercing) and allow beverage medium to exit the second portion when a force is applied to the barrier material.", "For example, the cartridge may include a piercing element that opens the second portion when a force is applied to the barrier material.", "In another embodiment, the wall includes corrugations and a frangible outlet that is openable based on pressure inside the second portion.", "The wall may be pressed so that the corrugations collapse, e.g., in a staged or sequential fashion, to force beverage medium through the outlet, which may include a burstable seal formed by a weakened portion of the wall (e.g., by scoring, partial perforation, etc.).", "Like the second portion, the first portion may be defined by a capsule formed by a layer of barrier material, and the first and second portions may be attached together, e.g., by crimping rims or edges of the barrier material together.", "The first and second portions may be sealed from an exterior environment and the first portion may contain a carbon dioxide source in solid form (such as a charged zeolite) arranged to emit carbon dioxide gas for use in mixing with a beverage precursor liquid to form a beverage.", "In one embodiment, a pressure in the first portion prior to breaking a seal of the first portion to expose the gas source may be relatively low, e.g., less than 100 psi.", "However, the gas source may be arranged to emit gas suitable for forming a carbonated beverage having a volume of between 100-1000 ml and a carbonation level of about 1 to 5.These and other aspects of the invention will be apparent from the following description and claims.", "BRIEF DESCRIPTION OF THE DRAWINGS Aspects of the invention are described with reference to the following drawings in which like numerals reference like elements, and wherein: FIG.", "1 shows a illustrative embodiment of a beverage making system having a removable reservoir; FIG.", "2 shows a illustrative embodiment of a beverage making system having a contactor arranged to circulate precursor liquid; FIG.", "3 shows a illustrative embodiment of a beverage making system in which liquid is carbonated in a single pass through a carbonator; FIG.", "4 shows an illustrative embodiment of a beverage making system in which a gas cartridge is located in a carbonation reservoir; FIG.", "5 shows an illustrative embodiment of a cartridge chamber; FIG.", "6 shows an illustrative embodiment of gas and beverage medium cartridges joined together; FIGS.", "7 and 8 shown perspective and top views, respectively, of gas and beverage medium cartridges; FIG.", "9 shows an illustrative embodiment of a cartridge arranged to carbonate a liquid in the cartridge; FIG.", "10 shows an illustrative embodiment of a cartridge arranged to carbonate a liquid in the cartridge in an alternative orientation; FIG.", "11 shows an illustrative embodiment of a cartridge having isolated chambers containing a gas source and a beverage medium; FIG.", "12 shows a cross sectional view of a cartridge having a movable part to configure the cartridge for use in forming a beverage; FIG.", "13 shows a cross sectional view of the FIG.", "12 cartridge after movement of the movable part; FIG.", "14 shows an exploded view of the FIG.", "12 cartridge; FIG.", "15 shows an exploded view of a cartridge having a first portion located over a second portion; FIG.", "16 shows a cross sectional view of the FIG.", "15 cartridge; FIG.", "17 shows a perspective view of a cartridge having a planar support; FIG.", "18 shows an exploded view of the FIG.", "17 cartridge; FIG.", "19 shows a cross sectional view of the FIG.", "17 cartridge; FIG.", "20 shows a cross sectional view of the FIG.", "17 cartridge with beverage medium being expelled from a second portion of the cartridge; FIG.", "21 shows a top view of a part of the support of the FIG.", "17 cartridge below the second portion; FIG.", "22 shows a schematic view of an arrangement in which precursor liquid and beverage media have a coaxial flow; FIG.", "23 shows a modification of the FIG.", "17 cartridge in which the second portion is positioned over the first portion; FIG.", "24 shows an exploded view of a cartridge having a mixing chamber portion; FIG.", "25 shows an assembled perspective view of the FIG.", "24 cartridge; FIG.", "26 shows a cross sectional view of the FIG.", "24 cartridge; FIG.", "27 shows a cross sectional view of the FIG.", "24 cartridge with beverage medium expelled from the second portion; FIG.", "28 shows a perspective view of a cartridge including side-by-side gas source and beverage medium portions; FIG.", "29 shows an exploded view of the FIG.", "28 cartridge; FIG.", "30 shows a cross sectional view of the FIG.", "28 cartridge; FIG.", "31 shows a schematic view of a beverage making system employing gravity and/or pressure feed of precursor liquid; FIG.", "32 shows a schematic view of a beverage making system with an ice dispensing function; FIG.", "33 shows a schematic view of a beverage making system employing heat or other activation of a gas source; FIG.", "34 shows a schematic view of a beverage making system employing a plunger to supply precursor liquid; FIG.", "35 shows a schematic view of a beverage making system arranged to cycle precursor liquid through a gas dissolution device; FIG.", "36 shows a schematic view of a cartridge having an activation fluid flow controller; FIGS.", "37 and 38 show a schematic view of a cartridge having an activation fluid flow controller that interacts with a beverage making machine; FIGS.", "39 and 40 show an arrangement in which pressure in a cartridge moves the cartridge to control activation fluid flow; FIGS.", "41 and 42 show a close up view of an activation fluid supply needle and activator inlet of a cartridge for use in the FIGS.", "39 and 40 embodiment; FIGS.", "43 and 44 show an illustrative embodiment in which pressure in a cartridge is detected by a beverage making machine; FIG.", "45 shows a cross sectional view of a cartridge arranged similarly to that in FIGS.", "28-30 and arranged to allow for pinch control of fluid flow in the cartridge; FIG.", "46 shows another embodiment in which pressure in a cartridge is detected by a beverage making machine; FIGS.", "47 and 48 show an embodiment in which pressure in a cartridge is detected by a beverage making machine and activation fluid flow is controlled by a valve actuator of the machine; FIGS.", "49 and 50 show a schematic diagram of a flow controller arrangement for a cartridge for automatic gas pressure control; FIG.", "51 shows a cross sectional view of a cartridge having a filter; FIG.", "52 shows an exploded view of another embodiment of a cartridge having a filter; FIGS.", "53 and 54 show cross sectional views of the second portion and the first portion, respectively of the FIG.", "52 embodiment; FIG.", "55 shows a cut away perspective view of an insert end of the cartridge of FIG.", "52; FIG.", "56 shows a cross sectional view of a cartridge arranged to allow a user to define a beverage characteristic by interacting with the cartridge; FIG.", "57 shows a perspective view of the FIG.", "56 cartridge; FIG.", "58 shows an assembled view of a cartridge having first and second portions joined such that lid portions are adjacent each other; FIG.", "59 shows a side view of the FIG.", "58 embodiment with the first and second portions detached; FIG.", "60 shows a top view of the FIG.", "59 arrangement; FIG.", "61 shows a cartridge with first and second portions joined together by a lid section and in a folded configuration; FIG.", "62 shows the FIG.", "61 embodiment in an unfolded configuration; FIG.", "63 shows a cross sectional view of an illustrative cartridge with an internal piercing element; FIG.", "64 shows an exploded view of a cartridge having a portion formed as a gusseted bag and another portion received into the gusset cavity; and FIG.", "65 shows a cartridge with a second portion containing a beverage medium and a pressurized gas used to expel the beverage medium.", "DETAILED DESCRIPTION It should be understood that aspects of the invention are described herein with reference to the figures, which show illustrative embodiments.", "The illustrative embodiments described herein are not necessarily intended to show all embodiments in accordance with the invention, but rather are used to describe a few illustrative embodiments.", "Thus, aspects of the invention are not intended to be construed narrowly in view of the illustrative embodiments.", "In addition, it should be understood that aspects of the invention may be used alone or in any suitable combination with other aspects of the invention.", "In accordance with one aspect of the invention, a fluid (such as water, water vapor, or other) may be provided to a carbon dioxide or other gas source in a cartridge so as to cause the gas source to emit gas that is used to carbonate or otherwise for dissolution in a liquid.", "In one embodiment, beverage making machine may include a gas activating fluid supply arranged to provide fluid to a cartridge chamber for contact with the gas source so as to cause the gas source to emit gas.", "In other arrangements, the gas source may be caused to release gas in other ways, such as by heating, exposing the source to microwaves or other electromagnetic radiation, etc.", "A gas supply of the machine may be arranged to conduct gas emitted by the gas source, under pressure greater than the ambient pressure, to a precursor liquid to carbonate the precursor liquid.", "In some embodiments, the gas source may be in solid form, such as a zeolite, activated carbon or other molecular sieve that is charged with carbon dioxide or other gas, and the use of a cartridge may not only isolate the gas source from activating agents (such as water vapor in the case of a charged zeolite), but also potentially eliminate the need for a user to touch or otherwise directly handle the carbon dioxide source.", "Having a gas activating fluid supply may enable the use of another aspect of the invention, i.e., a volume or other measure of the fluid provided to the cartridge may be controlled to control the rate or amount of gas that produced by the gas source.", "This feature can make the use of some gas sources, such as a charged zeolite material, possible without requiring gas storage or high pressure components.", "For example, zeolites charged with carbon dioxide tend to release carbon dioxide very rapidly and in relatively large quantities (e.g., a 30 gram mass of charged zeolite can easily produce 1-2 liters of carbon dioxide gas at atmospheric pressure in a few seconds in the presence of less than 30-50 ml of water).", "This rapid release can in some circumstances make the use of zeolites impractical for producing relatively highly carbonated liquids, such as a carbonated water that is carbonated to a level of 2 volumes or more.", "(A carbonation “volume” refers to the number of volume measures of carbon dioxide gas that is dissolved in a given volume measure of liquid.", "For example, a 1 liter amount of “2 volume” carbonated water includes a 1 liter volume of water that has 2 liters of carbon dioxide gas dissolved in it.", "Similarly, a 1 liter amount of “4 volume” carbonated water includes a 1 liter volume of water that has 4 liters of carbon dioxide dissolved in it.", "The gas volume measure is the gas volume that could be released from the carbonated liquid at atmospheric or ambient pressure and room temperature.)", "That is, dissolution of carbon dioxide or other gases in liquids typically takes a certain amount of time, and the rate of dissolution can only be increased a limited amount under less than extreme conditions, such as pressures within about 150 psi of ambient and temperatures within about +/−40 to 50 degrees C. of room temperature.", "By controlling the rate of carbon dioxide (or other gas) production for a carbon dioxide (or other gas) source, the total time over which the carbon dioxide (or other gas) source emits carbon dioxide (or other gas) can be extended, allowing time for the carbon dioxide (gas) to be dissolved without requiring relatively high pressures.", "For example, when employing one illustrative embodiment incorporating one or more aspects of the invention, the inventors have produced liquids having at least up to about 3.5 volume carbonation levels in less than 60 seconds, at pressures under about 40 psi, and at temperatures around 0 degrees Celsius.", "This capability allows for a carbonated beverage machine to operate at relatively modest temperatures and pressures, potentially eliminating the need for relatively expensive high pressure tanks, conduits and other components, as well as extensive pressure releases, containment structures and other safety features that might otherwise be required, particularly for a machine to be used in the consumer's home.", "Of course, as discussed above and elsewhere herein, aspects of the invention are not limited to use with carbon dioxide, and instead any suitable gas may be dissolved in a liquid in accordance with all aspects of this disclosure.", "In another aspect of the invention, a portion of a precursor liquid that is used to form a beverage may be used to activate the gas source.", "This feature may help simplify operation of a beverage making machine, e.g., by eliminating the need for special activation substances.", "As a result, a beverage making machine, or a method of forming a sparkling beverage, may be made less expensively and/or without special purpose ingredients.", "For example, in the case of a machine making carbonated water, all that is needed to activate the carbon dioxide source may be a portion of the water used to form the beverage.", "It should be understood, however, that other aspects of the invention need not require the use of a portion of precursor liquid to activate a carbon dioxide source, and instead may use any suitable activating agent, such as a citric acid in aqueous form that is added to a bicarbonate material, heat, microwave or other electromagnetic radiation used to activate a zeolite source, and others.", "For example, the cartridge that includes the carbon dioxide source may include (as part of the source), an activating agent whose addition to another component of the carbon dioxide source is controlled to control carbon dioxide production.", "FIG.", "1 shows one illustrative embodiment that incorporates at least the aspects of providing a fluid to a cartridge and/or cartridge chamber to activate a gas source, as well as controlling the fluid flow to control gas production, and the use of a portion of beverage precursor liquid to activate a gas source.", "The beverage making system 1 of FIG.", "1 includes a beverage precursor liquid 2 that is contained in a reservoir 11.The beverage precursor liquid 2 can be any suitable liquid, including water (e.g., flavored or otherwise treated water, such as sweetened, filtered, deionized, softened, carbonated, etc.", "), or any other suitable liquid used to form a beverage, such as milk, juice, coffee, tea, etc.", "(whether heated or cooled relative to room temperature or not).", "The reservoir 11 is part of a beverage precursor supply 10, which also includes a lid 12 that engages with the reservoir 11 to form a sealed enclosure, a pump 13 to circulate the precursor liquid 2, and a nozzle, showerhead or other component 14 that serves to disperse the precursor liquid 2 in a headspace in the reservoir 11.Of course, the precursor supply 10 may be arranged in other ways, e.g., to include additional or different components.", "For example, the reservoir 11 and lid 12 may be replaced with a closed tank that has suitable inlet/outlet ports, the pump 13 and/or nozzle 14 may be eliminated, and or other changes.", "In this embodiment, the reservoir 11 is initially provided with the precursor liquid 2 by a user, who provides the liquid 2 in the reservoir 11, e.g., from a water tap or other source.", "The user may also provide ice or other cooling medium in the reservoir 11 as desired, so as to cool the ultimate beverage made.", "In other embodiments, the system 1 may include a refrigeration system or other cooling system (such as that found in refrigerators, air conditioning units, thermoelectric cooling units, or other devices used to remove heat from a material) to cool the liquid 2 whether before, during and/or after carbonation.", "In some arrangements, cooling the precursor liquid 2 may help the carbonation process, e.g., because cooler liquids tend to dissolve carbon dioxide or other gas more rapidly and/or are capable of dissolving larger amounts of gas.", "However, in one aspect of the invention, a carbonated liquid may be cooled after the carbonation process is complete, e.g., just before discharge using a flow through chiller.", "This feature may allow the system 1 to chill only the beverage, and not other portions of the system, such as the reservoir 11, carbonator, pump, etc., reducing the heat output by the system 1.Although a user initially provides the beverage precursor liquid 2 in the reservoir 11, the precursor supply 10 may include other components to provide liquid 2 to the reservoir 11, such as a plumbed water line, controllable valve, and liquid level sensor to automatically fill the reservoir 11 to a desired level, a second water reservoir or other tank that is fluidly connected to the reservoir 11 (e.g., such as a removable water tank found with some coffee making machines along with a pump and conduit to route water from the removable tank to the reservoir 11), and other arrangements.", "The beverage making system 1 also includes a carbon dioxide activating fluid supply 20 that provides a fluid to a cartridge 4 so as to activate a carbon dioxide source 41 to release carbon dioxide gas.", "In this embodiment, the carbon dioxide source 41 is located in a portion of the cartridge 4 and includes a charged adsorbent or molecular sieve, e.g., a zeolite material that has adsorbed some amount of carbon dioxide gas that is released in the presence of water, whether in vapor or liquid form.", "Of course, other carbon dioxide source materials may be used, such as charcoal or other molecular sieve materials, carbon nanotubes, metal organic frameworks, covalent organic frameworks, porous polymers, or source materials that generate carbon dioxide by chemical means, such as sodium bicarbonate and citric acid (with the addition of water if the bicarbonate and acid are initially in dry form), or others.", "In addition, aspects of the invention are not necessarily limited to use with carbon dioxide gas, but may be used with any suitable gas, such as nitrogen, which is dissolved in some beers or other beverages, oxygen, air, and others.", "Thus, reference to “carbonation”, “carbon dioxide source” “carbon dioxide activating fluid supply”, etc., should not be interpreted as limiting aspects of the invention and/or any embodiments to use with carbon dioxide only.", "Instead, aspects of the invention may be used with any suitable gas.", "In one embodiment, the charged adsorbent is a zeolite such as analcime, chabazite, clinoptilolite, heulandite, natrolite, phillipsite, or stilbite.", "The zeolite may be naturally occurring or synthetic, and may be capable of holding up to about 20% carbon dioxide by weight or more.", "The zeolite material may be arranged in any suitable form, such as a solid block (e.g., in disc form), particles of spherical, cubic, irregular or other suitable shape, and others.", "An arrangement that allows the zeolite to flow or be flowable, e.g., spherical particles, may be useful for packaging the zeolite in individual cartridges.", "Such an arrangement may allow the zeolite to flow from a hopper into a cartridge container, for example, simplifying the manufacturing process.", "The surface area of the zeolite particles may also be arranged to help control the rate at which the zeolite releases carbon dioxide gas, since higher surface area measures typically increase the gas production rate.", "Generally, zeolite materials will release adsorbed carbon dioxide in the presence of water in liquid or vapor form, allowing the zeolite to be activated to release carbon dioxide gas by the addition of liquid water to the zeolite.", "The carbon dioxide activating fluid supply 20 in this embodiment includes a conduit that is fluidly coupled to the pump 13 and a valve 21 that can be controlled to open/close or otherwise control the flow of precursor liquid 2 into the cartridge 4.As can be seen, circulation of the liquid 2 by the pump 13 can allow the activating fluid supply 20 to divert some (e.g., a first portion) of the precursor liquid 2 to the cartridge chamber 3 to cause the creation of carbon dioxide gas, e.g., by opening the valve 21.Other arrangements or additions are possible for the carbon dioxide activating fluid supply 20, such as a suitably sized orifice in the conduit leading from the pump 13 outlet to the cartridge 4, a pressure-reducing element in the conduit, a flow-restrictor in the conduit, a flow meter to indicate an amount and/or flow rate of liquid into the cartridge 4, and so on.", "In addition the liquid source 20 need not use precursor liquid 2 to activate the carbon dioxide source 41, but instead may use a dedicated source of fluid for activation.", "For example, the carbon dioxide activating fluid supply 20 may include a syringe, piston pump or other positive displacement device that can meter desired amounts of liquid (whether water, citric acid or other material) that are delivered to the cartridge 4.In another embodiment, the activating fluid supply 20 may include a gravity fed liquid supply that has a controllable delivery rate, e.g., like the drip-type liquid supply systems used with intravenous lines for providing liquids to hospital patients, or may spray atomized water or other liquid to provide a water vapor or other gas phase activating fluid to the cartridge 4.Moreover, although FIG.", "1 suggests that the activating fluid supply 20 provides liquid to a top of the cartridge 4, the liquid source 20 may provide the fluid to a bottom of the cartridge 4, e.g., to flood the bottom of the cartridge, or other suitable location.", "It is also conceivable that an activating liquid can be provided in the cartridge with the carbon dioxide source 42, e.g., in a chamber that is pierced to allow contact of the liquid with the source 42.In accordance with one embodiment, the cartridge 4 (having one or more portions) may be located in a cartridge chamber 3 during carbon dioxide production.", "As a result, the cartridge 4 may be made of a relatively flexible material or otherwise constructed so that the cartridge 4 cannot withstand a relatively high pressure gradient between the interior and exterior of the cartridge 4.That is, the cartridge chamber 3 may contain any pressure generated by the carbon dioxide source 41 and support the cartridge 4 as necessary.", "In this illustrative embodiment, the cartridge 4 is contained in a closed and sealed chamber 3 that has a space or gap surrounding all or most of the cartridge 4.The pressure between the interior space of the cartridge 4 and the exterior of the cartridge 4 is allowed to equalize, e.g., by allowing some of the gas emitted by the carbon dioxide source 41 to “leak” into the space around the cartridge 4, and so even if the cartridge 4 is made of a relatively semi-rigid, flexible or weak material, the cartridge 4 will not burst or collapse.", "In alternate arrangements, the cartridge 4 may be made to fit a receiving space in the cartridge chamber 3 so that the chamber 3 supports the cartridge 4 when pressure is built up inside the cartridge 4.This support may be suitable to prevent the cartridge 4 from bursting or otherwise preventing the cartridge 4 from functioning as desired.", "In yet other embodiments, the cartridge 4 may be made suitably robust (either in whole or in part) so as to withstand relatively high pressures (e.g., 1 atm or more) in the cartridge interior space.", "In such a case, the cartridge chamber 3 need not function as much more than a physical support to hold the cartridge 4 in place or otherwise establish a connection to the cartridge for gas output by the cartridge 4 and/or liquid supply to the cartridge 4.For example, the cartridge chamber 3 in such an arrangement may simply include a connection port that serves to fluidly and physically couple the cartridge 4 to the system 1.Thus, in some embodiments, the cartridge may be mechanically robust enough to withstand pressures up to 90 psig, e.g., like a conventional carbonated soft drink can, and be fluidly coupled to the system 1, but without receiving physical support from the system 1 (e.g., the cartridge may be exposed and not enclosed by walls of a chamber) to prevent the cartridge 4 from bursting during use.", "A carbon dioxide gas supply 30 may be arranged to provide carbon dioxide gas from the cartridge chamber 3 to an area where the gas is used to carbonate the liquid 2.The gas supply 30 may be arranged in any suitable way, and in this illustrative embodiment includes a conduit 31 that is fluidly connected between the cartridge chamber 3 and the reservoir 11, and a filter 32 that helps to remove materials that may contaminate the precursor liquid 2, such as particles from the carbon dioxide source 41.The gas supply 30 may include other components, such as pressure regulators, safety valves, control valves, a compressor or pump (e.g., to increase a pressure of the gas), an accumulator (e.g., to help maintain a relatively constant gas pressure and/or store gas), and so on.", "(The use of an accumulator or similar gas storage device may obviate the need to control the rate of gas output by a cartridge.", "Instead, the gas source may be permitted to emit gas in an uncontrolled manner, with the emitted gas being stored in an accumulator for later delivery and use in producing a sparkling beverage.", "Gas released from the accumulator could be released in a controlled manner, e.g., at a controlled pressure and/or flow rate.)", "In this embodiment, the conduit 31 extends below the surface of the precursor liquid 2 in the reservoir 11 so that the carbon dioxide gas is injected into the liquid 2 for dissolution.", "The conduit 31 may include a sparging nozzle or other arrangement to aid in dissolution, e.g., by creating relatively small gas bubbles in the liquid 2 to increase the dissolution rate.", "Alternately, the conduit 31 may deliver the gas to a headspace (if present) in the reservoir 11 rather than below the surface of the liquid 2.Carbonation of the precursor liquid 2 may occur via one or more mechanisms or processes, and thus is not limited to one particular process.", "For example, while carbon dioxide gas delivered by the conduit 31 to the reservoir 11 may function to help dissolve carbon dioxide in the liquid 2, other system components may further aid in the carbonation process.", "In this illustrative embodiment, the precursor supply 10 may assist in carbonating the liquid by circulating the liquid via the pump 13 and the nozzle 14.That is, liquid 2 may be drawn from the reservoir 13 via a dip tube 15 and sprayed by the nozzle 14 into a carbon dioxide-filled headspace in the reservoir 11.As is known in the art, this process can help the liquid 2 to dissolve carbon dioxide gas, e.g., by increasing the surface area of liquid 2 exposed to gas.", "While in this embodiment the dip tube 15 is separate from the reservoir 11 and extends below the surface of the precursor liquid 2, the dip tube 15 may be arranged in other ways, such as being made integrally with the wall of the reservoir 11.Ifthe dip tube 15 is made integrally with the reservoir 11, connecting the reservoir 11 to the lid 12 may establish a fluid connection between the dip tube 15 and the pump 13.Forming the dip tube 15 integrally with the reservoir 11 may allow the system 1 to accommodate differently sized (and thus different volume) reservoirs 11.In addition, this arrangement may help ensure that only suitably configured reservoirs 11 (e.g., a container arranged to withstand system pressures) is used.", "Alternately, the dip tube 15 could be made flexible or otherwise accommodate reservoirs 11 having a different height.", "Whether integral with the reservoir 11 or not, the dip tube 15 may include a filter, strainer or other arrangement to help prevent small particles, such as ice chips, from being drawn into the pump 13.In some embodiments, the reservoirs 11 can function as a drinking glass as well as a reservoir 11 in the system 1.That is, a user may provide a reservoir/drinking glass 11 to the system 1 (e.g., including a desired amount of water, ice and/or beverage medium), and after carbonation is complete, use the reservoir/drinking glass 11 to enjoy the beverage.", "The reservoir 11 may be insulated, e.g., to help keep a beverage cold, as well as made to withstand suitable pressures experienced in use with the system 1.The various components of the system 1 may be controlled by a controller 5, which may include a programmed general purpose computer and/or other data processing device along with suitable software or other operating instructions, one or more memories (including non-transient storage media that may store software and/or other operating instructions), a power supply for the controller 5 and/or other system components, temperature and liquid level sensors, pressure sensors, RFID interrogation devices, input/output interfaces (e.g., to display information to a user and/or receive input from a user), communication buses or other links, a display, switches, relays, triacs, motors, mechanical linkages and/or actuators, or other components necessary to perform desired input/output or other functions.", "In this illustrative embodiment, the controller 5 controls the operation of the valve 21 of the activating fluid supply 20 as well as the pump 13 of the precursor liquid supply 10.Also shown in FIG.", "1 is a sensor 51, which may represent one or more sensors used by the controller 5.For example, the sensor 51 may include a temperature sensor that detects the temperature of the precursor liquid in the reservoir 11.This information may be used to control system operation, e.g., warmer precursor liquid temperatures may cause the controller 5 to increase an amount of time allowed for carbon dioxide gas to be dissolved in the precursor liquid 2.In other arrangements, the temperature of the precursor liquid 2 may be used to determine whether the system 1 will be operated to carbonate the liquid 2 or not.", "For example, in some arrangements, the user may be required to add suitably cold liquid 2 (and/or ice) to the reservoir 11 before the system 1 will operate.", "(As discussed above, relatively warm precursor liquid 2 temperatures may cause the liquid to be insufficiently carbonated in some conditions.)", "In another embodiment, the sensor 51 may include a pressure sensor used to detect a pressure in the reservoir 11.This information may be used to determine whether the reservoir 11 is improperly sealed to the lid 12 or another pressure leak is present, and/or to determine whether sufficient carbon dioxide gas is being produced by the cartridge 4.For example, low detected pressure may cause the controller 5 to allow more liquid to be delivered by the activating fluid supply 20 to the cartridge 4, or prompt the user to check that the reservoir 11 is properly engaged with the lid 12.Likewise, high pressures may cause the flow of liquid from the activating fluid supply 20 to be slowed or stopped.", "Thus, the controller 5 can control the gas pressure in the reservoir 11 and/or other areas of the system 1 by controlling an amount of liquid delivered to the cartridge 4 and/or the cartridge chamber 3.The sensor 51 may alternately, or additionally, detect that the reservoir 11 is in place, and/or whether the reservoir 11 is properly engaged with the lid 12.For example, a switch may be closed when the reservoir 11 is properly seated on a seal of the lid 12, indicating proper engagement.", "In another arrangement, the reservoir 11 may include an RFID tag or other electronic device that is capable of communicating its identity or other characteristics of the reservoir 11 to the controller 5.This information may be used to confirm whether the reservoir 11 is suitable for use with the system 1, to control certain operating conditions (e.g., an operating pressure may be limited based on the type of reservoir used, the precursor liquid may be carbonated to a level that corresponds to the reservoir 11, and so on), and/or for other uses.", "The sensor 51 could also detect the presence of a cartridge 4 in the chamber 3, e.g., via RFID tag, optical recognition, physical sensing, etc.", "Ifno cartridge 4 is detected, or the controller 5 detects that the cartridge 4 is spent, the controller 5 may prompt the user to insert a new or different cartridge 4.For example, in some embodiments, a single cartridge 4 may be used to carbonate multiple volumes of precursor liquid 2.The controller 5 may keep track of the number of times that the cartridge 4 has been used, and once a limit has been reached (e.g., 10 drinks), prompt the user to replace the cartridge.", "Other parameters may be detected by the sensor 51, such as a carbonation level of the precursor liquid 2 (which may be used to control the carbonation process), the presence of a suitable vessel to receive a beverage discharged from the system 1 (e.g., to prevent beverage from being spilled), the presence of water or other precursor liquid 2 in the reservoir 11 or elsewhere in the precursor supply 10, a flow rate of liquid in the pump 13 or associated conduit, the presence of a headspace in the reservoir 11 (e.g., if no headspace is desired, a valve may be activated to discharge the headspace gas, or if only carbon dioxide is desired to be in the headspace, a snifting valve may be activated to discharge air in the headspace and replace the air with carbon dioxide), and so on.", "The controller 5 may also be arranged to allow a user to define a level of carbonation (i.e., amount of dissolved gas in the beverage, whether carbon dioxide or other).", "For example, the controller 5 may include a touch screen display or other user interface that allows the user to define a desired carbonation level, such as by allowing the user to select a carbonation volume level of 1, 2, 3, 4 or 5, or selecting one of a low, medium or high carbonation level.", "All cartridges used by the system 1 may include sufficient gas source material to make the highest level of carbonation selectable, but the controller 5 may control the system to dissolve an amount of gas in the beverage that is consistent with the selected level.", "For example, while all cartridges may be arranged for use in creating a “high” carbonation beverage, the controller 5 may operate the system 1 to use less of the available gas (or cause the gas source to emit less gas than possible) in carbonating the beverage.", "Carbonation levels may be controlled based on a detected carbonation level by a sensor 51, a detected pressure in the reservoir or elsewhere, an amount of gas output by the cartridge 4, or other features.", "In another embodiment, the cartridge 4 may include indicia readably by the controller, e.g., an RFID tag, barcode, alphanumeric string, etc., that indicates a carbonation level to be used for the beverage.", "After determining the carbonation level from the cartridge 4, the controller 5 may control the system 1 accordingly.", "Thus, a user need not select the carbonation level by interacting with the system 1, but rather a carbonation level may be automatically adjusted based on the beverage selected.", "In yet another embodiment, a user may be able to select a gas source cartridge 4 that matches a carbonation level the user desires.", "(Different carbonation levels may be provided in the different cartridges by having different amounts of gas source in the cartridge 4.)", "For example, cartridges providing low, medium and high carbonation levels may be provided for selection by a user, and the user may pick the cartridge that matches the desired carbonation level, and provide the selected cartridge to the system 1.Thus, a gas source cartridge labeled “low” may be chosen and used with the system to create a low level carbonated beverage.", "A user may alternately be permitted to define characteristics of a beverage to be made by interacting in some way with a cartridge 4 to be used by the system 1.For example, tab, notch or other physical feature of the cartridge may be altered or formed by the user to signify a desired beverage characteristic.", "For example, a broken tab, slider indicator, a covered or uncovered perforation on a portion of the cartridge, etc., that is created by the user may indicate a desired carbonation level, an amount of beverage medium to use in forming the beverage (where the system 1 is controllable to use less than all of the beverage medium in the cartridge to form a beverage), and so on.", "Features in the cartridge 4 may also be employed by the controller 5 detect features of the cartridge, a beverage being formed or other components of the system 1.For example, light guides in a cartridge 4 may provide a light path to allow the controller 5 to optically detect a level of beverage medium in the cartridge 4, a flow of precursor liquid in the cartridge 4, pressure in the cartridge (e.g., where deflection of a cartridge portion can be detected and indicates a pressure), a position of a piston, valve or other cartridge component, an absence of beverage medium in the cartridge (to signify completion of beverage formation), and so on.", "Other sensor features may be incorporated into the cartridge, such as electrical sensor contacts (e.g., to provide conductivity measurements representative of a carbonation level or other properties of a precursor liquid), an acoustic sensor (to detect gas emission, fluid flow, or other characteristics of the cartridge), and so on.", "To cause the beverage making system 1 to create a carbonated beverage, a user may first provide a desired amount of precursor liquid 2 in the reservoir 11, along with optional ice and/or a beverage medium.", "Alternately, the carbonated liquid may be flavored after carbonation is complete either by automated or manual means.", "The reservoir 11 is then engaged with the lid 12, such as by engaging a screw thread on the reservoir 11 with the lid 12, activating a clamp mechanism, or other.", "A cartridge 4 containing a carbon dioxide source 41 (e.g., in solid form, such as a charged zeolite) may be placed in the cartridge chamber 3 and the chamber 3 closed.", "In other embodiments, the cartridge 4 may be otherwise fluidly coupled to the system 1, such as by engaging a threaded portion of the cartridge 4 with a corresponding port of the system.", "The cartridge chamber 3 may operate in any suitable way, e.g., like that found in many cartridge-based coffee or other beverage machines.", "For example, a manual lever may be operated to lift a lid of the chamber 3, exposing a cartridge receiver portion of the chamber 3.With the cartridge 4 in the chamber 3, the lever may be again activated to close the lid, sealing the chamber 3 closed.", "With the cartridge 4 associated with the system 1, the controller 5 may then activate the system 1 to deliver liquid to the chamber 3, e.g., to cause carbon dioxide to be generated.", "The controller 5 may start operation in an automated way, e.g., based on detecting the presence of a cartridge 4 in the chamber 3, liquid 2 in the reservoir 11 and closure of the chamber 3.Alternately, the controller 5 may start system operation in response to a user pressing a start button or otherwise providing input (e.g., by voice activation) to start beverage preparation.", "The controller 5 may start operation of the pump 13, drawing liquid from the dip tube 15 and discharging the liquid 2 at the nozzle 14.The valve 21 may be opened to deliver a suitable portion of the precursor liquid 2 to the chamber 3, and carbon dioxide gas created may be provided to the reservoir 11 by the gas supply 30.Operation may continue for a preset amount of time, or based on other conditions, such as a detected level of carbonation, a drop in gas production by the cartridge 4, or other parameters.", "During operation, the amount of liquid provided to the chamber 3 may be controlled to control gas output by the cartridge 4.Control of the liquid provided to the cartridge 4 may be made based on a timing sequence (e.g., the valve 21 may be opened for a period of time, followed by valve closure for a period, and so on), based on detected pressure (e.g., liquid supply may be stopped when the pressure in the chamber 3 and/or reservoir 11 exceeds a threshold, and resume when the pressure falls below the threshold or another value), based on a volume of activating liquid delivered to the chamber 3 (e.g., a specific volume of liquid may be delivered to the cartridge 4), or other arrangements.", "When complete, the user may remove the beverage and reservoir 11 from the lid 12.FIG.", "1 shows only one illustrative embodiment of a beverage making system 1, but other arrangements are possible, including systems that incorporate other aspects of the invention.", "For example, in one aspect of the invention, flavoring of a sparkling beverage may be done in an automated way, and may occur in a cartridge.", "This feature may make the beverage formation process easier and more convenient for a user, as well as help reduce the likelihood of cross contamination between beverages and/or the need to rinse a mixing chamber.", "That is, by mixing a beverage medium with the precursor liquid in a cartridge (which may be disposable), each beverage made by the system 1 may effectively be made using its own mixing chamber.", "For example, if a carbonated cherry beverage is made using the system 1, followed by lemon beverage, there may be a possibility that the cherry flavor left behind in a mixing chamber will carry over into the subsequent lemon beverage.", "Rinsing or other cleaning of a mixing chamber can help eliminate or reduce such flavor cross over, but mixing each beverage in a cartridge may eliminate the need to rinse a mixing chamber or other system components entirely.", "Mixing of the beverage medium with precursor liquid may occur in a dedicated mixing chamber of the cartridge(s), in a cartridge portion that holds a beverage medium, and/or in a cartridge portion that holds a gas source.", "However, it should be understood that a beverage medium may be mixed with a precursor liquid in other ways, such as by expelling the beverage medium from a cartridge directly into a user's cup or other container, or into a mixing chamber of the beverage making machine.", "Thus, the beverage medium could be mixed with sparkling water or other liquid directly in the user's cup.", "In another aspect of the invention, precursor liquid may be carbonated using a contactor (a type of carbonator or gas dissolving device) that includes a porous membrane (e.g., that is porous at least to gas) having a gas side and a liquid side.", "Precursor liquid on the liquid side of the carbonator may be exposed to gas on the gas side of the membrane, and since the membrane may be arranged to increase the surface area of the liquid exposed to gas, dissolution of carbon dioxide or other gas into the precursor liquid may be done more rapidly than using other techniques.", "In one embodiment, the carbonator may include a contactor with a hollow fiber arrangement in which hollow fibers made of a hydrophobic material, such as polypropylene, carry the precursor liquid.", "The fibers are porous, having holes that, combined with the hydrophobicity of the material, allow for contact of gas on the exterior of the fibers with the liquid while preventing the liquid from exiting the fiber interior.", "Membrane contactors suitable for such use are made by Membrana of Charlotte, N.C., USA.", "Of course, other “membrane” arrangements may be used, such as arrangements that prevent bulk flow of liquid across a barrier, but allow gas to pass through the barrier for dissolution in the liquid.", "For example, a membrane having a flat, spiral wound and/or a flat, interdigitated arrangement could be used instead of a hollow fiber arrangement.", "Also, in some arrangements the flow of gas through the contactor may be generally opposite that of the flow of liquid through the contactor, e.g., to help with gas exchange.", "However, other flow arrangements are possible.", "In yet another aspect of the invention, a cartridge chamber of a beverage making system may be arranged to hold first and second cartridge portions where the first cartridge portion contains a carbon dioxide source arranged to emit carbon dioxide gas for use in carbonating the precursor liquid, and the second cartridge portion contains a beverage medium arranged to be mixed with a liquid precursor to form a beverage.", "The cartridge chamber may have a single cartridge receiving portion for receiving both cartridge portions, or may include a plurality of cartridge receiving portions that are separate from each other, e.g., for receiving two or more cartridges that are each associated with a first or second cartridge portion.", "Such an arrangement may help simplify use of the system, particularly where the cartridge portions are arranged for only a single use, e.g., formation of a single volume of beverage and discarded thereafter.", "For example, a user may be enabled to place one or two cartridges that include the first and second cartridge portions in receiving portions of the cartridge chamber without the need for establishing pressure-tight, leak-proof or other connections needed for the system to operate properly.", "Instead, the cartridge portions may be simply placed in a receiver, and the cartridge chamber closed, making the system ready for beverage production.", "FIG.", "2 shows another illustrative embodiment that incorporates the aspects of using a membrane contactor to carbonate the precursor liquid with a cartridge-provided gas, mixing a beverage medium with liquid in a cartridge, and the use of a cartridge chamber that receives first and second cartridge portions that respectively contain a gas source and beverage medium.", "This embodiment is similar to that in FIG.", "1 in many ways, and may be modified to have one or more components like that in FIG.", "1.However, certain alternate arrangements are shown in FIG.", "2 to illustrate another few ways in which a beverage making system 1 may be modified in accordance with aspects of the invention.", "In this embodiment, the reservoir 11 is a closed tank having no removable lid.", "Precursor liquid 2 may be provided to the reservoir 11 in any suitable way, such as by a plumbed water connection (not shown), by the pump 13 (or other pump) pumping liquid from a separate storage tank (not shown) into the reservoir 11, by a gravity feed of liquid from a separate storage tank through a controllable valve (not shown), and others.", "The reservoir 11 may have any suitable volume, and is fluidly coupled to a pump 13 that can circulate the precursor liquid 2 through a contactor 6 and back to the reservoir 11 via a nozzle 14.", "(Such a circulation feature may help in dissolving gas in a precursor liquid 2 and may be used in any beverage making system 1 described herein or otherwise contemplated within the scope of this disclosure.)", "As discussed above, the precursor liquid 2 may pass through hollow fibers in the contactor 6 to pick up carbon dioxide or other gas around the fibers, but this arrangement could be reversed, with gas flowing in the fibers and the precursor liquid 2 located on the exterior of the fibers.", "A filter 16 may be provided to remove materials in the precursor liquid 2 that might clog the fibers, pores in the fibers or otherwise interfere with the operation of the contactor 6.Alternately, or in addition, the filter 16 may condition the liquid 2, e.g., by softening, removing alkaline or other elements that tend to raise the pH of the liquid 2, by removing elements that may prevent the formation of a good tasting beverage, and so on.", "For example, the filter 16 may include an activated charcoal and/or other components found in commonly used water filters.", "The contactor 6 may be arranged to have a plurality of hollow fibers extending within a closed tube or other chamber so that the inner passages of the fibers fluidly connects a fluid inlet of the contactor 6 to a fluid outlet.", "The gas space around the fibers may communicate with the carbon dioxide supply 30 via one or more ports on the gas side of the contactor 6.It should be understood, however, that the contactor 6 may be arranged in other ways, such as having one or more membranes in the form of a flat sheet or other forms other than tubular to define a liquid side and a gas side of the contactor 6.The activating fluid supply 20 is arranged similarly to that in FIG.", "1, with a controllable valve 21 fluidly coupled to an output of the pump 13.However, in this embodiment, the activating fluid supply 20 introduces liquid near a bottom of the cartridge chamber 3 and the cartridge 4.This arrangement may help the activating fluid supply 20 to better control gas release from the carbon dioxide source 41.For example, dropping water onto the carbon dioxide source 41 from the top may allow the water to spread over a wide area, allowing charged zeolites or other source materials spread over a wide area to release gas.", "By providing liquid from below, the activating fluid supply 20 may flood the cartridge 4 and/or chamber 3, thereby allowing water to contact source materials 41 starting from the bottom up.", "This may allow for closer control of the volume of source materials 41 that are activated to release gas.", "In the case that the carbon dioxide source 41 can wick or otherwise move water upwardly (such as by capillary action), portions of the source 41 may be separated from each other by non-wicking agents.", "For example, the source 41 may include a set of stacked discs of zeolite material that are separated by a non-wicking material, such as metal or solid plastic separators.", "This may allow the fluid supply 20 to stepwise increase the fluid level in the cartridge 4 over a period of time to sequentially activate individual discs.", "Gas produced by the cartridge 4 is routed by the gas supply 30 (via an optional filter 32 and conduit 31) to the gas side of the contactor 6.The conduit 31 may include a water-buoyant check valve or other arrangement that allows gas to pass to the contactor 6, but prevents liquid from exiting the cartridge chamber 3.For example, a floating ball in the cartridge chamber 3 may normally leave an opening of the conduit 31 free for gas flow, but may raise upwardly on the surface of liquid in the cartridge 4 to close the opening, e.g., in case that the activating fluid supply 20 provides an excess of activating liquid.", "The controller 5 may monitor the gas pressure in the chamber 3, in the conduit 31 and/or in the gas side of the contactor 6 to control the activating fluid supply 20 and gas production.", "In one embodiment, the activating fluid supply 20 may be controlled to provide approximately 35-45 psi gas pressure at the gas side of the contactor 6.This pressure has been found to work at least adequately in carbonating about 400-500 ml of water at a temperature of about 0 degrees C. in about 30-60 seconds using a hollow fiber contactor, as described in more detail below in the Examples.", "As carbon dioxide in the contactor is dissolved into the precursor liquid 2, the pressure on the gas side will drop, prompting the controller 5 to supply additional liquid 2 to the cartridge 4a to cause additional gas to be created.", "Similar to the system in FIG.", "1, this process may be performed based on any criteria, such as the passage of a specific amount of time, the detection of a specified level of carbonation of the liquid 2, exhaustion of the carbon dioxide source 41, a volume of liquid delivered to the cartridge 4a, etc., so that a pressure of the carbon dioxide gas can be maintained within a desired range above ambient pressure.", "Once carbonation of the precursor liquid 2 is complete, the controller 5 may direct the liquid 2 to a beverage medium cartridge 4b in the cartridge chamber 3.While the precursor liquid 2 may be caused to flow from the reservoir 11 in any suitable way (such as by gravity, a pump, etc.", "), in this embodiment, the controller 5 activates an air pump 7 which pressurizes the reservoir 11 such that the precursor liquid 2 is forced to flow via a conduit to the cartridge chamber 3 and the beverage medium cartridge 4b.", "In other embodiments, gas pressure created by the carbon dioxide source 41 may be used to pressurize the reservoir 11 and drive the flow of the precursor liquid to the beverage medium cartridge 4b.", "For example, when carbonation is complete, gas from the cartridge 4a may be routed directly into the reservoir 11 instead of to the contactor 6 so as to pressurize the reservoir 11.Although no valve is shown in the conduit that fluidly couples the reservoir 11 and the cartridge 4b, a controllable valve, pump or other suitable component may be added to control flow as desired.", "The use of air or other gas to move liquid 2 through the cartridge 4b (or to expel beverage medium from the cartridge 4b) may allow the system 1 to “blow down” the cartridge 4b at or near the end of the beverage process, e.g., to remove any remaining material from the cartridge 4b.", "This may be useful in making the cartridge 4b less messy to handle (e.g., by reducing the likelihood that the cartridge 4b will drip when removed from the chamber 3.A similar process may be used to blow down the cartridge 4a, e.g., using an air pump or gas produced by the source 41.Flow of the precursor liquid 2 through the beverage medium cartridge 4b may cause the liquid 2 to mix with the beverage medium 42 before being discharged, e.g., to a waiting cup 8 or other container.", "The beverage medium cartridge 4b may include any suitable beverage making materials (beverage medium), such as concentrated syrups, ground coffee or liquid coffee extract, tea leaves, dry herbal tea, powdered beverage concentrate, dried fruit extract or powder, natural and/or artificial flavors or colors, acids, aromas, viscosity modifiers, clouding agents, antioxidants, powdered or liquid concentrated bouillon or other soup, powdered or liquid medicinal materials (such as powdered vitamins, minerals, bioactive ingredients, drugs or other pharmaceuticals, nutriceuticals, etc.", "), powdered or liquid milk or other creamers, sweeteners, thickeners, and so on.", "(As used herein, “mixing” of a liquid with a beverage medium includes a variety of mechanisms, such as the dissolving of substances in the beverage medium in the liquid, the extraction of substances from the beverage medium, and/or the liquid otherwise receiving some material from the beverage medium.)", "The liquid 2 may be introduced into the cartridge 4b in any suitable way, and/or the cartridge 4b may be arranged in any suitable way to aid in mixing of the liquid 2 with the beverage medium 42.For example, the precursor liquid 2 may be introduced into the cartridge 4b so as to cause a spiral or other flow pattern, the cartridge 4b may include a labyrinth or other tortuous flow path to cause turbulence in the flow to aid in mixing, and so on.", "One potential advantage of mixing the precursor liquid 2 in a beverage medium cartridge 4b is that cross contamination of beverage medium that may occur with the use of a mixing chamber that is used to mix beverage medium and liquid 2 for every beverage made by the system 1 may be avoided.", "However, the system 1 could be modified to employ a reused mixing chamber, e.g., a space where beverage medium 42 that is provided from a cartridge 4b and precursor liquid 2 are mixed together in much the same way that fountain drinks are formed by commercial drink machines.", "For example, the beverage medium 42 could be driven from the cartridge 4b (e.g., by air pressure, carbon dioxide gas pressure created by the cartridge 4a, by gravity, by suction created by an adductor pump, venturi or other arrangement, etc.)", "into a mixing chamber or the user's cup where the precursor liquid 2 is also introduced.", "Rinsing of the mixing chamber may or may not be necessary, e.g., to help prevent cross contamination between beverages.", "In some arrangements, the entire volume of beverage medium 42 may be discharged into the mixing chamber, causing initial amounts of flavored precursor liquid 2 exiting the mixing chamber to have a high beverage medium concentration.", "However, as the beverage medium 42 is swept from the mixing chamber by the precursor liquid 2, the precursor liquid itself may effectively rinse the mixing chamber.", "In arrangements where the beverage medium 42 is a dry material, such as a powder, some precursor liquid may be introduced into the cartridge to pre-wet the medium 42 or otherwise improve an ability to mix the medium 42 with precursor liquid 2.The wetted medium 42 may be mixed with additional precursor liquid 2 in the cartridge, or the wetted medium 42 may be expelled from the cartridge, e.g., by air pressure, a plunger, etc., to a mixing chamber or other location for additional mixing with precursor liquid 2.Liquid 2 may be introduced into a mixing chamber using multiple streams, e.g., to enhance a mixing rate using low flow speeds so as to reduce loss of dissolved gas.", "The embodiment of FIG.", "2 could be modified so that flow of precursor liquid 2 exiting the contactor 6 is routed directly to the beverage medium cartridge 4b or to another mixing chamber where beverage medium 42 is mixed with the carbonated precursor liquid 2, e.g., like that shown in FIG.", "3.That is, in this illustrative embodiment, carbonated precursor liquid 2 does not circulate from the reservoir 11, through the contactor 6 and back to the reservoir 11, but instead precursor liquid 2 makes a single pass through the contactor 6 and then proceeds to mixing with the beverage medium 42 in a mixing chamber 9 and discharge to a cup 8.However, the arrangement of FIG.", "3 could also include a circulation circuit to allow liquid 2 to be circulated from the reservoir 11 or other tank, through the contactor 6, and back to the reservoir 11 or other tank.", "The mixing chamber 9 may take any suitable form, e.g., may cause the precursor liquid 2 and beverage medium 42 to move in a spiral, swirl or other fashion to enhance mixing, may have one or more motor driven blades, impellers or other elements to mix contents in the chamber 9, and so on.", "While the mixing chamber 9 may be separate from the cartridge 4, the mixing chamber 9 could be incorporated into a cartridge 4 if desired.", "The mixing chamber 9 may be cooled as well, e.g., by a refrigeration system, to help cool the beverage provided to the cup 8.Alternately, the precursor liquid 2 may be cooled in the reservoir 11 and/or any other locations in the system.", "In the case where the carbonated liquid 2 is not flavored or where the liquid 2 is mixed with the beverage medium 42 before passing through the carbonator 6, the mixing chamber 9 may be eliminated or arranged to mix the precursor liquid 2 and beverage medium 42 upstream of the contactor 6.Alternately, the precursor liquid supply 10 may be arranged to mix the precursor liquid 2 with the beverage medium 42 in the cartridge 4b prior to routing the liquid 2 to the contactor 6.In this embodiment, the beverage medium 42 may be delivered to the mixing chamber 9 by any suitable means, such as air or other gas pressure (e.g., as supplied by an air pump, the gas source 41 or other), by gravity feed (e.g., by the opening of a valve or door), by introducing all or part of the precursor liquid 2 used to make the beverage into the second cartridge 4b, by compressing the cartridge 4b to force the medium 42 to flow to the mixing chamber 9, and others.", "The controller 5 may detect the gas pressure on the gas side of the contactor 6, and control fluid supply to the cartridge 4a accordingly, e.g., to maintain a suitable gas pressure in the contactor 6.The reservoir 11 may be a water storage tank that is not pressurized in this embodiment, and may be removable from the system 1, e.g., to make filling by a user easier.", "The user may add ice and/or beverage medium to the precursor liquid 2 in the reservoir 11, if desired.", "Alternately, the reservoir 11 and pump 13 may be replaced by a plumbed connection to a pressurized water supply and an optional control valve and/or pressure reducer.", "Of course, as with other embodiments, the system 1 may be suitably enclosed in a housing having a visible display, user input buttons, knobs, or touch screen, user-operated devices for opening/closing a cartridge chamber, and other features found in beverage making machines.", "Other arrangements for a beverage forming system 1 are possible, such as that shown in FIG.", "4.In this illustrative embodiment, the cartridge chamber 3 is combined with the reservoir 11 such that the cartridge 4a having a carbon dioxide source 41 is located in the reservoir 11.The cartridge 4a may be placed in the reservoir 11/cartridge chamber 3 by removing the lid 12 from the reservoir 11.Liquid may be provided to the cartridge 4a by any suitable activating fluid supply 20, such as an arrangement like that in FIG.", "1, a syringe or piston pump that delivers a metered amount of liquid to the cartridge 4a, and others.", "In this embodiment, the carbon dioxide supply 30 is combined with the reservoir 11 such that a portion of the reservoir functions to deliver carbon dioxide gas to the precursor liquid 2.The pump 13 may aid the carbonation process by circulating the liquid 2 and spraying the liquid 2 into a carbon dioxide-filled headspace in the reservoir 11.In another embodiment, a contactor 6 may be provided in the reservoir 11 (e.g., at the location of the nozzle 14) so that the liquid 2 flows through hollow fibers extending downwardly from the lid 12 while carbon dioxide in the headspace is absorbed by the liquid while passing through the fibers.", "In yet another arrangement, the membrane portion of a contactor 6 may be at least partially submerged in the precursor liquid 2, and gas from the source 41 may be passed through hollow fibers of the contactor 6.As a result, the liquid 2 on the outside of the fibers may pick up carbon dioxide from the gas passing through the fibers.", "In such an arrangement, the fibers of the contactor 6 may be located in the reservoir 11 or other tank as shown, or could be located in the user's cup 8.In this way, liquid 2 could be carbonated or otherwise have gas dissolved while in the cup 8.While the cartridge chamber 3 may be arranged in any suitable way, FIG.", "5 shows one illustrative arrangement in which both a carbon dioxide source cartridge 4a and a beverage medium cartridge 4b can be received by the same cartridge chamber 3.In this embodiment, the cartridges 4a, 4b (which respectively have a portion that contains a gas source 41 and beverage medium 42) are received in separate cartridge receivers 33, and each cartridge receiver 33 may include a piercing element 34 at a bottom of the cartridge receiver 33.The piercing element 34, which may include a hollow needle, spike, blade, knife or other arrangement, may form an opening in the respective cartridge 4.Alternately, the cartridges 4 may have defined openings, e.g., one or more ports, that include a septum or other valve-type element that permits flow into and/or out of the cartridge 4.Similarly, the lid 12 may include piercing element 35 that form an opening in the top of the respective cartridge 4, e.g., when the lid 12 is closed.", "When closed, the lid 12 may form a sealed chamber in which the cartridges 4a, 4b are located and isolated from each other.", "The openings formed in the cartridges 4a, 4b may allow for communication with the interior space of the cartridges 4a, 4b as outlined in FIG.", "5.For example, an opening at the top of the cartridge 4a may allow carbon dioxide or other gas to exit the cartridge chamber 3, while the opening at the bottom of the cartridge 4a may allow for water or other activating fluid to enter the cartridge 4a.", "Of course, the openings may be formed in other locations, such as an opening for allowing fluid input to occur at the top or side of the cartridge.", "Likewise, gas may exit the cartridge through a bottom, side or otherwise located opening.", "As mentioned above, gas may be permitted to leak from the cartridge 4a into the space in the cartridge chamber 3 around the cartridge 4a, e.g., through the opening in the cartridge 4a, through a hole or other opening in the piercing element 35, etc.", "This may allow the pressure around the cartridge to equalize with the pressure inside the cartridge during gas production, helping to prevent bursting of the cartridge 4a.", "Alternately, the cartridge 4a may fit closely into the cartridge receiver 33 so that the cartridge chamber 3 can support the cartridge 4a (if necessary).", "The opening in the top of the beverage medium cartridge 4b may allow for precursor liquid 2 to be introduced into the cartridge 4b (e.g., for mixing with the beverage medium), or for pressurized air or other gas to enter the cartridge (e.g., for forcing the beverage medium 42 from the cartridge 4b and into a mixing chamber or cup).", "The opening at the bottom of the cartridge 4b may allow for beverage to exit to a waiting cup or other container, or for the beverage medium to travel to a mixing chamber or cup.", "As with the cartridge 4a, opening in the beverage medium cartridge 42 may be arranged in any suitable location or locations.", "The cartridge chamber 3 may open and close in any suitable way to allow cartridges 4 to be placed in and/or removed from the chamber 3.In the FIG.", "5 embodiment, the lid 12 is pivotally mounted to the receiver portion of the chamber 3, and may be opened and closed manually, such as by a handle and linkage arrangement, or automatically, such as by a motor drive, to close the cartridge receivers 33.In other embodiments, the lid 12 may have two or more sections that are each associated with a respective cartridge receiver 33.Thus, the lid sections can be moved independently of each other to open/close the cartridge receivers 33.Of course, the lid 12 may be arranged in other ways, such as being engaged with the receivers 33 by a threaded connection (like a screw cap), by the receivers 33 moving away and toward the lid 12 while the lid 12 remains stationary, by both the lid and receiver portion moving, and so on.", "In addition, a cartridge chamber 3 need not necessarily have a lid and receiver arrangement like that shown in FIG.", "5, but instead may have any suitable member or members that cooperate to open/close and support a cartridge.", "For example, a pair of clamshell members may be movable relative to each other to allow receipt of a cartridge and physical support of the cartridge.", "Some other illustrative cartridge chamber arrangements are shown, for example, in U.S. Pat.", "Nos.", "6,142,063; 6,606,938; 6,644,173; and 7,165,488.As mentioned above, the cartridge chamber 3 may allow a user to place one or more cartridges in the chamber 3 without the need for the user to take special steps to establish a pressure-tight, leak-proof or other specialized connection between the cartridge and other portions of the system 1.Instead, in some embodiments, the user may be able to simply place the cartridge in a receiving space, and close the cartridge chamber.", "The cartridges 4 used in various embodiments may be arranged in any suitable way, such as a relatively simple frustoconical cup-shaped container having a lid attached to the top of the container, e.g., like that in some beverage cartridges sold by Keurig, Incorporated of Reading, Mass.", "and shown in U.S. Pat.", "No.", "5,840,189, for example.", "In one embodiment, a cartridge having a frustoconical cup-shaped container and lid may have an approximate diameter of about 30-50 mm, a height of about 30-50 mm, an internal volume of about 30-60 ml, and a burst resistance of about 80 psi (i.e., a resistance to cartridge bursting in the presence of a pressure gradient of about 80 psi from the inside to outside of the cartridge in the absence of any physical support for the cartridge).", "However, as used herein, a “cartridge” may take any suitable form, such as a pod (e.g., opposed layers of filter paper encapsulating a material), capsule, sachet, package, or any other arrangement.", "The cartridge may have a defined shape, or may have no defined shape (as is the case with some sachets or other packages made entirely of flexible material.", "The cartridge may be impervious to air and/or liquid, or may allow water and/or air to pass into the cartridge.", "The cartridge may include a filter or other arrangement, e.g., in the beverage medium cartridge 4b to help prevent some portions of the beverage medium from being provided with the formed beverage, and/or in the gas cartridge 4a to help prevent carbon dioxide source material from being introduced into the beverage or other system components.", "In one aspect of the invention, the cartridge or cartridges used to form a beverage using the beverage making system may have a volume that is less, and in some cases substantially less, than a beverage to be made using the cartridge(s).", "For example, if carbon dioxide and beverage medium cartridges 4 are used, the cartridges may each have a volume that is about 50 ml or less, and be used to form a beverage having a volume of about 200-500 ml or more.", "The inventors have found (as shown in some of the Examples below) that an amount of charged carbon dioxide adsorbent (e.g., a charged zeolite) of about 30 grams (which has a volume of less than 30 ml) can be used to produce about 400-500 ml of carbonated water having a carbonation level of up to about 3.5 volumes.", "Moreover, it is well known that beverage-making syrups or powders having a volume of less than about 50 ml, or less than about 100 ml, can be used to make a suitably flavored beverage having a volume of about 400-500 ml.", "Thus, relatively small volume cartridges (or a single cartridge in some arrangements) having a volume of about 100 ml to about 250 ml or less may be used to form a carbonated beverage having a volume of about 100 to 1000 ml, and a carbonation level of at least about 1.5 to 4 volumes in less than 120 seconds, e.g., about 60 seconds, and using pressures under 50 psi.", "While the carbon dioxide and beverage medium cartridges 4 can be provided separately, in one embodiment, the cartridges 4 may be joined together, like that shown in FIG.", "6.The cartridges 4a, 4b may be connected together by any suitable arrangement, such as tabs 43 that extend from respective cartridges 4a, 4b and are attached together, e.g., by thermal welding, adhesive, interlocking mechanical fasteners such as snaps or clips, etc.", "This arrangement may allow the cartridges 4a, 4b to be made separately in the manufacturing setting, e.g., because the cartridges require very different processes for manufacturing.", "For example, the beverage medium cartridge 4b may require a highly sterile environment, whereas the gas cartridges 4a need not be made in such an environment.", "In contrast, the gas cartridges 4a may need to be manufactured in a water vapor-free environment, whereas the beverage medium cartridge 4b may not be subject to such requirements.", "After manufacture of the cartridges 4a, 4b, the cartridges may be attached together in a way that prevents their separation without the use of tools (such as a scissor) and/or damage to one or both of the cartridges.", "The cartridge chamber 3 may be arranged to accommodate the attached cartridges, allowing a user to place a single item in the chamber 3 to form a beverage.", "In addition, the cartridges 4 and/or the way in which the cartridges are attached, together with the arrangement of the cartridge chamber 3 may help ensure that the gas cartridge 4a and beverage medium cartridge 4b are placed in the proper cartridge receiver 33.For example, the cartridges 4 may have different sizes, shapes or other configurations so that the combined cartridges 4 cannot be placed into the chamber 3 in the wrong orientation.", "Alternately, the controller 5 may detect that the cartridges have been improperly placed (e.g., by communicating with an RFID tag on one or both of the cartridges, by optically or otherwise identifying the cartridges, etc.", "), and prompt the user to make a change as necessary.", "FIGS.", "7 and 8 show another embodiment in which a pair of cartridges are joined together in a way that helps prevent improper placement of the cartridges in a chamber and/or enables the cartridges to operate in other orientations.", "As shown in FIG.", "7, the cartridges 4a and 4b are attached by a connection 43 such that with the cartridge 4a arranged in an upright orientation with the container bottom 44 facing downward and the lid 45 covering the top of the container facing upward, the cartridge 4b is on its side with the lid 45 facing to the side.", "FIG.", "8 shows a top view of the embodiment, with the lid 45 of the cartridge 4a facing the viewer and the lid 45 of the cartridge 4b facing downwardly.", "This arrangement may be useful in embodiments where the cartridges 4 are pierced only at the lid area, e.g., are not pierced in the bottom 44 or other portions of the container.", "That is, the gas cartridge 4a may be pierced at the lid 45 to allow liquid to be introduced into the cartridge 4a, and to allow gas to exit.", "In some embodiments, the inlet for introduction of activating fluid (liquid and/or gas) may be the same opening as the outlet for gas emitted by the gas source.", "For example, a single hole may be pierced in the lid 45 through which water is introduced, and through which gas emitted by the gas source exits.", "Similarly, the lid 45 of the cartridge 4b may be pierced to allow liquid to be introduced into the cartridge 4b for mixing with the beverage medium 42 and to allow a flavored beverage to exit the cartridge 4b.", "Avoiding piercing of the container may be useful in arrangements where the container is made of a relatively thick and/or rigid material (e.g., to withstand operating pressures for the cartridge 4).", "In another aspect of the invention, a single cartridge may be used to provide a carbonating gas as well as a beverage medium.", "In fact, in some embodiments, the precursor liquid can be both carbonated and flavored in the same cartridge.", "For example, FIG.", "9 shows a cross sectional view of a cartridge 4 that includes both a gas source 41 (e.g., a zeolite carbon dioxide source) and a beverage medium 42.In this embodiment, the cartridge 4 includes first and second chambers (or portions) 46, 47 that respectively contain the gas source 41 and the beverage medium 42.The first and second chambers (or portions) 46, 47 may be separated from each other by a permeable element, such as a filter, or an impermeable element, such as a wall molded with the cartridge container.", "In this embodiment, the first and second chambers (or portions) 46, 47 are separated by a filter 48 that is attached to the lid 45, but could be arranged in other ways.", "Precursor liquid and/or an activating liquid may be introduced into the first chamber 46 by a piercing element 35 or other arrangement, such as a port formed as part of the cartridge 4.The interior space of the cartridge 4 may be maintained under pressure, e.g., 30-150 psi above ambient or greater, so that dissolution of carbon dioxide gas released by the source 41 occurs more rapidly than would occur at lower pressures.", "In addition, the system 1 arranged to use such cartridges may include a backpressure valve or other arrangement that helps to maintain a suitable pressure in the cartridge 4, e.g., as an aid to carbonation.", "As mentioned above, a cartridge chamber 3 that holds the cartridge 4 may be arranged to closely fit the cartridge 4 as needed to support the cartridge and prevent the cartridge from bursting.", "Alternately, pressure in the cartridge 4 may be allowed to leak into a space around the cartridge 4 to equalize the pressures inside and outside of the cartridge, or the cartridge may be made to withstand operating pressures without physical or other support.", "Carbonated precursor liquid 2 and/or a liquid/gas bubble mixture may pass through the filter 48 into the second chamber 47 for mixing with the beverage medium 42.Thereafter, the precursor liquid 2 and beverage medium 42 mixture may exit the cartridge 4, e.g., through a piercing element 34 at the container bottom 44.Dissolution of carbon dioxide into the precursor liquid 2, as well as mixing of the beverage medium 42 with the liquid 2, may continue after the materials exit the cartridge 4.For example, a mixing chamber may be located downstream of the cartridge 4 to help more thoroughly mix the beverage medium and liquid if needed.", "Also, a conduit downstream of the cartridge may help continue dissolution of gas, e.g., by maintaining pressure in the liquid.", "While FIGS.", "9 and 10 show an arrangement in which the gas source 41 and the beverage medium 42 are separated by a filter 48, in other arrangements the gas source 41 and beverage medium 42 may be mixed together, e.g., so that a precursor liquid 2 is both mixed with beverage medium 42 and exposed to gas from the gas source 41 at a same time.", "In some cases, gas that is not dissolved into the liquid 2 may be routed to another location, such as a contactor 6, for exposure to and dissolution into the liquid 2 at an upstream or downstream location, e.g., to increase a level of dissolved gas.", "In one embodiment, particles of gas source material 41 may be coated with a beverage medium 42.In the embodiments above, the cartridge 4 has been described to have a defined bottom and top with the cartridge operating in an upright configuration.", "However, as suggested in connection with FIGS.", "7 and 8, a cartridge may be operated in any suitable orientation.", "For example, FIG.", "10 shows an embodiment in which a cartridge configured like that in FIG.", "9 is used while the cartridge 4 is on its side.", "(Note that the cartridge 4b in FIGS.", "7 and 8 may be used in a similar way to that shown in FIG.", "10.)", "Precursor liquid may be introduced into the first chamber (or portion) 46 (e.g., via the piercing element 35), causing the gas source 41 to emit gas and at least partially flooding the cartridge 4 interior space.", "As with the FIG.", "9 embodiment, the liquid may be carbonated and mix with the beverage medium 42 before exiting the cartridge, e.g., via the piercing element 34.As also mentioned above, a single cartridge 4 may be arranged to have first and second chambers 46, 47 that are isolated or separated from each other.", "FIG.", "11 shows one such embodiment in which first and second chambers (or portions) 46, 47 are separated by a wall 49.A cartridge like that shown in FIG.", "11 may be used, for example, in a system 1 like that shown in FIG.", "2, although the cartridge chamber 3 may need to be modified to accommodate the single cartridge 4.As shown in FIG.", "11, in one embodiment, activating liquid may be provided via a piercing element 35 at a top of the first chamber (or portion) 46, and gas may exit via the same or a different opening.", "Alternately, activating liquid may be introduced via the piercing element 34 at the bottom of the first chamber (or portion) 46, and gas may exit via the piercing element 35 at the top.", "In yet another embodiment, precursor liquid may be introduced at the top piercing element 35 and carbonated liquid may exit via the bottom piercing element 34.The first chamber (or portion) 46 may include a filter or other suitable components, e.g., to help prevent the gas source 41 from exiting the chamber (or portion) 46.Regarding the second chamber (or portion) 47, air or other gas may be introduced via the piercing element 35 at a top of the second chamber (or portion) 47, causing beverage medium 42 to be moved out of the piercing element 34 at the bottom of the second chamber (or portion) 47, e.g., to a mixing chamber or user's cup.", "Alternately, precursor liquid may be introduced via the piercing element 35 at a top of the second chamber 47, may mix with the beverage medium 42 and exit the cartridge 4 out of the piercing element 34.As discussed above, the piercing element 34, 35 arrangement in this illustrative embodiment should not be interpreted as limiting aspects of the invention in any way.", "That is, piercing elements need not be used, but instead flow into/out of the cartridge 4 may occur through defined ports or other openings in the cartridge 4.Also, flow ports or other openings in the cartridge need not necessarily be located at the top, bottom or other specific location.", "The cartridge(s) may be made of any suitable materials, and are not limited to the container and lid constructions shown herein.", "For example, the cartridge(s) may be made of, or otherwise include, materials that provide a barrier to moisture and/or gases, such as oxygen, water vapor, etc.", "In one embodiment, the cartridge(s) may be made of a polymer laminate, e.g., formed from a sheet including a layer of polystyrene or polypropylene and a layer of EVOH and/or other barrier material, such as a metallic foil.", "Moreover, the cartridge(s) materials and/or construction may vary according to the materials contained in the cartridge.", "For example, a gas cartridge 4a may require a robust moisture barrier, whereas a beverage medium cartridge 4b may not require such a high moisture resistance.", "Thus, the cartridges may be made of different materials and/or in different ways.", "In addition, the cartridge interior may be differently constructed according to a desired function.", "For example, a beverage medium cartridge 4b may include baffles or other structures that cause the liquid/beverage medium to follow a tortuous path so as to encourage mixing.", "The gas cartridge 4a may be arranged to hold the gas source 41 in a particular location or other arrangement in the interior space, e.g., to help control wetting of the source 41 with activating liquid.", "A cartridge may also be arranged to provide a visual or other detectable indication regarding the cartridge's fitness for use in forming a beverage.", "For example, the cartridge may include a pop-up indicator, color indicator or other feature to show that the gas source has been at least partially activated.", "Upon viewing this indication, a user may determine that the cartridge is not fit for use in a beverage making machine.", "In another embodiment, an RFID tag may be associated with a sensor that detects gas source activation (e.g., via pressure increase), beverage medium spoilage (e.g., via temperature increase), or other characteristic of the cartridge, which may be transmitted to a reader of a beverage making machine.", "The machine may display the condition to a user and/or prevent activation of the machine to use the cartridge to form a beverage.", "In another aspect of the invention, a cartridge may include a gas source portion, a beverage medium portion and a mixing chamber portion (also referred to as first, second and third portions, respectively) that are separated from each other.", "Thus, as discussed above, a cartridge may include a mixing chamber that is separate from a portion that is used to hold a beverage medium prior to use of the cartridge.", "The first portion may contain a gas source for emitting a gas to be dissolved in a beverage precursor liquid, the second portion may contain a beverage medium for use in mixing with a beverage precursor liquid to form a beverage, and the third portion may be arranged to receive beverage medium from the second portion and receive precursor liquid to mix the precursor liquid with the beverage medium.", "The precursor liquid may enter the third portion with the beverage medium and/or enter the third portion via a separate flow path.", "Thus, the cartridge may be capable of mixing a precursor liquid (e.g., whether carbonated or not) with beverage medium and outputting a mixed beverage (e.g., for later carbonation).", "This may help avoid the need to clean a mixing chamber, e.g., because the cartridge may be made disposable so that each beverage is made using its own mixing chamber.", "FIGS.", "12, 13 and 14 show a cross sectional view of a cartridge 4 having first, second and third portions prior to configuration ready to make a beverage, a cross sectional view of the cartridge 4 after being configured to make a beverage, and an exploded perspective view of the cartridge, respectively.", "In this embodiment, the cartridge 4 includes a first portion 46 that partially surrounds a second portion 47 and a third portion 62, e.g., the first portion 46 has parts positioned around the second and third portions 47, 62 in at least one plane.", "Also, the third portion 62 partially surrounds the second portion 47.However, this concentric arrangement of the first, second and third portions 46, 47, 62 is not required, as these portions may be arranged in any suitable way with respect to each other.", "A top end of the first, second and third portions 46, 47, 62 is sealed closed by a lid 45, e.g., a foil laminate that is part of the cartridge container.", "(In one embodiment, the lid 45 may include two or more separate portions, such as a first part that covers the second portion 47 after beverage medium is placed, and a second part that covers the first portion 46 (and possibly the second portion 47 as well) after the gas source 41 is placed.", "This may make filling of the first and second portions 46, 47 easier during manufacturing.)", "As a result, the first portion 46 may be isolated from an external environment, e.g., to help resist contact of the gas source 41 with moisture or other materials.", "By virtue of a closure at the beverage medium outlet 47b of the second portion, e.g., a burstable or frangible membrane, septum, etc., the second portion 47 is likewise isolated from an exterior environment, so as to help prevent spoilage of the beverage medium 42, as necessary.", "While a top region of the third portion 62 is closed by the lid 45, a bottom region of the third portion 62 may be left open, or may be covered by another element, such as a second lid or other cover.", "This embodiment incorporates another aspect of the invention, i.e., that a cartridge may include a movable part arranged to move so as to configure the cartridge useable for making a beverage.", "For example, the movable part may move relative to the cartridge container to open the gas source portion and/or the beverage medium portion, e.g., as shown in FIG.", "13.In the illustrative embodiment of FIG.", "12, the movable part 61 includes a plurality of piercing elements 34, 35 arranged to form one or more openings in the lid 45, although other arrangements are possible.", "For example, a movable part 61 may move to open a valve so as to open an inlet or outlet of the cartridge 4, to break off a tab or other frangible element to open an inlet or outlet, couple a pair of conduits together, and so on.", "In this embodiment, the movable part 61 includes a piercing element 35 to form an activator inlet 46a into the first portion 46, e.g., to allow the introduction of fluid (liquid water or water vapor) to activate the gas source 41.The movable part 61 also includes a piercing element 34 to form a gas outlet 46b into the first portion 46, allowing for gas emitted by the gas source 41 to exit the cartridge 4, e.g., for dissolving into a precursor liquid and forming of a beverage.", "It is also possible that a single piercing element 34/35 may function to form the inlet 46a and the outlet 46b, e.g., where a same hole in the lid 45 serves to admit activating fluid and emit gas.", "A piercing element 35 is also included to form a precursor liquid inlet 47a into the second portion 47 to allow the introduction of precursor liquid (whether having a substantial amount of dissolved gas or not) for mixing with the beverage medium 42 and helping to move the beverage medium 42 from the second portion 47 and into the third portion 62.Precursor liquid may also be introduced into the third portion 62 by one or more piercing elements 35 for mixing with the beverage medium 42.Thus, in accordance with an aspect of the invention, the cartridge 4 may be arranged to direct a portion of precursor liquid used to make a beverage through a beverage medium portion, and bypass or otherwise direct a remaining portion of the precursor liquid into a mixing chamber portion of the cartridge.", "In one embodiment, approximately 10-40% of the precursor liquid used to form a beverage may be introduced into the second portion 47 and about 60-90% of the precursor liquid may be introduced into the third portion 62.Of course, other relative amounts may be used, as suitable.", "Precursor liquid may be introduced into the third portion 62 to creating a swirling action, turbulence or other motion to help mix the precursor liquid and the beverage medium.", "The portion of precursor liquid introduced into the second portion 47 may help wet the beverage medium 42, e.g., where the beverage medium 42 is a powdered material, which may help with mixing.", "In accordance with an aspect of the invention, the cartridge 4 may include a lock element that prevents movement of a movable part, e.g., which is movable to configure the cartridge suitable to form a beverage, and the lock element may be releasable by a user.", "As shown in FIG.", "12, the cartridge container or the movable part 61 may include a lock ring 71 that prevents the movable part 61 from moving relative to the container, e.g., to pierce the lid 45.The lock ring 71 may be removable or otherwise releasable by a user, e.g., by pulling on a tab that causes the lock ring 71 to separate from the container at a perforation or other line of weakness.", "The lock element may take other arrangements, such as one or more break-off fins or tabs, a removable plug, or other structure.", "In another arrangement, the lock element may be removed or otherwise released by the beverage making machine, e.g., after the cartridge 4 is associated with the machine and a door closed.", "Another aspect of the invention incorporated into the cartridge of FIG.", "12 is that the gas source portion at least partially surrounds the beverage medium portion and/or the mixing chamber portion.", "This feature may help enlarge the volume of the gas source portion without unnecessarily enlarging the cartridge, e.g., to help the gas source portion store gas emitted by the gas source without experiencing large pressure changes that might be present in a smaller volume chamber.", "That is, a somewhat larger gas source chamber volume may provide the gas source chamber with an ability to store gas emitted by the gas source while smoothing pressure variations.", "Thus, the gas source portion may be arranged to function as a kind of accumulator that stores gas emitted by the gas source.", "While in this embodiment the cartridge 4 includes a movable part 61 with piercing elements, the cartridge 4 need not include a movable part 61 that moves to configure the cartridge for forming a beverage.", "Instead, the cartridge 4 may be arranged without the movable part 61, and a beverage machine that uses the cartridge may include a suitable set of piercing elements or other components arranged to interact with the cartridge to communicate with inlets and/or outlets of the cartridge as suitable.", "In another aspect of the invention, a cartridge may include an activation fluid inlet that directs an activation fluid to a bottom of the gas source portion.", "This arrangement may allow for improved control of gas release, e.g., because a gas source may be exposed to activation fluid from a bottom to a top.", "Thus, if the activation fluid is water, a lower part of the gas source portion may be flooded with water, causing a lower layer of the gas source to be activated.", "However, higher layers of gas source may remain unactivated because the activation water does not reach above a lower part of the gas source.", "To activate upper players of the gas source, more water may be provided to the gas source portion, raising the top level of the activation fluid in the gas source portion.", "Flooding of the gas source portion may be continued at a controlled rate, thereby controlling gas emission of the gas source.", "This arrangement may help avoid wetting a gas source from a top surface of the source, such as by sprinkling water on the top surface of a charge of zeolite material.", "This sprinkling may cause uncontrolled wetting, and thus activation, of the source, causing the gas source to emit gas in a less controlled way.", "FIGS.", "15 and 16 show an exploded view and a cross sectional view, respectively, of an illustrative embodiment of a cartridge 4 that includes an activation fluid inlet that provides activation fluid to a bottom of the gas source portion.", "In this illustrative embodiment, the first portion 46 includes a gas source 41 and an activator inlet 46a with a conduit that extends from near a top of the first portion 46 to near a bottom of the first portion 46.Thus, for example, a beverage making machine may pierce a lid 45 that seals the first portion 46 and the activator inlet 46a closed, and introduce water into the activator inlet 46a.", "The water may flow down the conduit of the inlet 46a and into the bottom of the first portion 46, wetting a lower layer of gas source and causing the gas source to emit gas.", "Of course, other activation fluids may be used, such as citric acid, water vapor, etc.", "Also, while in this embodiment the activator inlet 46a includes a conduit that is molded into the sidewall of the container body, the activator inlet 46a may be arranged in other ways, such as by a conduit that extends from a bottom wall of the first portion 46, a conduit that extends downwardly from a piercing element, and so on.", "Emitted gas may exit via another opening in the first portion 46 (such as a molded port or pierced opening) or may exit via the activator inlet 46a (e.g., via small holes in the inlet 46a near a top of the conduit that allow gas to pass but resist the passage of liquid water, or via a trap such as an “S” shaped conduit that resists liquid water flow).", "Other ways of controlling gas release may be used in a cartridge, such as encapsulating gas source material 41 in a structure that bursts, dissolves or otherwise degrades to expose the interior gas source to activating fluid.", "For example, capsules containing gas source 41 may be arranged to dissolve at different rates, thereby releasing gas source material for activation in a time-release fashion.", "Other arrangements are possible as well, such as a first portion 46 that has multiple steps or platforms on which gas source 41 is located.", "As the first portion 46 is flooded with water or other activator, the gas source 46 at each step may be exposed one after the other, thereby causing a staged emission of gas.", "Another aspect of the invention incorporated into the embodiment of FIGS.", "15 and 16 is a spiral-shaped, helical, zig-zag or other tortuous flowpath channel that holds beverage medium and helps precursor liquid flowing in the spiral-shaped channel to mix with the beverage medium.", "For example, the cartridge 4 includes a precursor liquid inlet 47a that directs precursor liquid into an outer region of a spiral-shaped channel (in this case, via a downwardly extending conduit that extends from a top of the first portion 46 to the second portion 47).", "Beverage medium 42 is arranged in the spiral-shaped channel to partially fill the depth of the channel so that precursor liquid may flow over and/or in the beverage medium.", "As the precursor liquid flows through the spiral-shaped channel, beverage medium may mix with the liquid, forming the beverage.", "The spiral-shaped channel may be arranged to provide for laminar flow, e.g., to help reduce loss of carbonation or other dissolved gases in the precursor liquid, if present.", "Alternately, the spiral shaped or other tortuous channel may be arranged to provide turbulent flow, potentially helping to mix the precursor liquid and beverage medium.", "Mixed beverage medium and precursor liquid exiting the cartridge near a center of the spiral shaped channel may pass directly into a user's cup or may enter a mixing chamber, whether part of the cartridge or the beverage making machine.", "Flow channel shapes other than spiral may be used, e.g., a helical, zig-zag, and/or serpentine pathway may be arranged to provide laminar or other flow characteristics.", "Thus, a cartridge second portion that contains beverage medium may include any suitable flow arrangements to help mix a precursor liquid with beverage medium.", "The embodiment of FIGS.", "15 and 16 also includes a feature that an outlet of the second portion 47 may include a closure (e.g., a cap) that is arranged to be broken off, pierced, removed or otherwise opened by a user and/or by a beverage making machine.", "Thus, the outlet need not necessarily be opened by a presence of pressure in the second portion 47.Also, the first and second portions 46, 47 in this embodiment are made of separate parts that are held together by a sleeve 75 that wraps around the portions 46, 47.The sleeve 75 may also function to seal the side of the precursor inlet 47a, and/or the activator inlet 46a.", "However, it should be understood that the first and second portions 46, 47 may be made as a single, unitary piece, and configured to eliminate any need for a sleeve 75.In accordance with another aspect of the invention, a beverage medium portion of a cartridge may include a wall that is movable to expel beverage medium from the beverage medium portion.", "For example, the beverage medium portion may be defined by a barrier layer (e.g., a foil laminate) that is arranged to surround a beverage medium.", "The barrier layer may be flexible so that the second portion of the cartridge can be squeezed, pressed or otherwise have a force exerted on it so as to reduce the volume of the second portion to force the beverage medium from the second portion.", "For example, the barrier layer may form a pouch that contains beverage medium, and the pouch may be squeezed to force the beverage medium to exit, e.g., into a user's cup, a mixing chamber of the cartridge, or other location where the beverage medium is mixed with a liquid precursor.", "In another illustrative arrangement, the second portion may include a syringe-type arrangement where a plunger is moved in the second portion to force beverage medium from the second portion.", "Other arrangements are possible, as discussed more below.", "FIGS.", "17-20 show a perspective view, an exploded view, a cross-sectional view during gas output and a cross-sectional view during beverage medium mixing of an illustrative embodiment having a movable element to expel beverage medium from the cartridge.", "In this embodiment, the cartridge container includes a planar support 72 that supports a first portion 46, located below the support 72, and a second portion 47 located above the support 72.The first portion 46 is formed integrally with the support 72, e.g., is molded as a unitary part with the support 72, but could be formed in other ways, such as by a separate part that is attached to the support 72.The first portion 46 has a hemispherical shape with an activator inlet 46a near a bottom of the first portion 46 and a gas outlet 46b on a top side of the planar support 72.", "(As with all embodiments described herein, relative terms “top”, “bottom”, etc., are used for ease of description and understanding, and should not be understood as limiting the cartridge arrangements, their orientation during use, or other features of the cartridge.)", "Thus, water or other activation fluid may be introduced near a bottom of the first portion 46, e.g., to controllably flood the first portion 46, with gas emitted by the gas source 41 exiting via a port on the support 72.The activator inlet 46a and gas outlet 46b may be opened by a piercing element, physical action to remove a break off tab, removal of a peel off foil, etc.", "The second portion 47 in this embodiment includes a blister pouch that is formed by a layer of barrier material, such as a foil laminate.", "The second portion 47 may have any shape or size, but in this embodiment has a generally disc-like shape with a dome-like upper surface.", "A lower part of the blister pouch includes a layer of barrier material that covers a substantial part of the top surface of the support 72, e.g., to seal the first portion 46 closed as well as form a bottom of the second portion 47, but may be arranged in other ways.", "The blister pouch overlies a spike 73 on the support 72 so that if the blister pouch is urged toward the support 72, e.g., as shown in FIG.", "20, the spike 73 may pierce the second portion 47, releasing the beverage medium.", "Accordingly, movement of a wall (e.g., an upper part of the blister pouch) of the second portion 47 may cause beverage medium to exit the second portion 47.Movement of the wall may be caused by a plunger of the beverage making machine pressing down on the second portion 47 (as shown in FIG.", "20), or in other ways.", "For example, gas pressure generated by the gas source 41 may be routed to a suitable location (such as into the second portion 47, a pneumatic bladder, or to the plunger of the beverage making machine) to force beverage medium from the second portion 47.In accordance with another aspect of the invention, beverage medium exiting the second portion 47 may be directed to a precursor liquid inlet 47a, e.g., where carbonated water is introduced into the cartridge.", "In this embodiment, the cartridge includes four precursor inlet ports, though other numbers of ports may be used.", "Also, an upper surface of the support 72 around the spike 73 is arranged to provide flow paths for the beverage medium so as to direct the beverage medium to areas near the precursor liquid inlets 47a.", "For example, FIG.", "21 shows a top view of a portion of the support 72 that underlies the second portion 47.In this embodiment, the support 72 defines four flow paths for the beverage medium 42 to travel from near the spike 73 to each of the precursor liquid inlets 47a.", "As a result, when the second portion 47 is pierced by the spike 73 and beverage medium is released, the beverage medium may flow outwardly to the inlets 47a.", "(Flow of beverage medium 42 may occur with both liquid and solid (e.g., powdered) beverage media.)", "Thus, beverage medium may be encouraged to dissolve more rapidly and/or completely, e.g., because the beverage medium may be divided into relatively small portions to increase its surface area and contact with precursor liquid.", "It should be understood that other arrangements may be used to route beverage medium movement to a precursor liquid inlet 47a.", "For example, four spikes 73 may be provided on the support 72, with one spike 73 located near a respective inlet 47a.", "Thus, the second portion 47 may be pierced in locations adjacent each inlet 47a, causing beverage medium to be released from the second portion 47 directly into the inlets 47a.", "In another embodiment, the spikes 73 may each include a flow channel (e.g., include a hollow piercing needle) so that beverage medium 42 is caused to flow through the spike 73 to a desired location adjacent an inlet 47a.", "Other configurations will occur to those of skill in the art.", "One feature of the arrangement shown in FIG.", "21 is that beverage medium may be introduced to precursor liquid in a direction transverse to the flow of the precursor liquid, which may help break the flow of beverage medium up into smaller particles and increase a dissolution rate.", "For example, beverage medium 42 introduced at each of the inlets 47a may flow generally perpendicularly to the flow of precursor liquid into the inlets 47a.", "Alternately, beverage medium may be directed into a flow of precursor liquid in a coaxial fashion, e.g., a central flow of beverage medium may be surrounded by a coaxial flow of precursor liquid.", "For example, FIG.", "22 shows an illustrative embodiment in which the support 72 includes flow channels to direct precursor liquid 2 to multiple locations where beverage medium 42 is released from the second portion 27, e.g., by multiple spikes 73 on the support 72.The regions where the precursor liquid 2 and beverage medium 42 meet may be configured so that the liquid 2 generally surrounds the beverage medium 42, e.g., in a coaxial flow.", "The flow rates of the respective flows may be adjusted to help enhance mixing or other characteristics of beverage production, such as foam production, air entrainment, and so on.", "For example, faster flowing precursor liquid 2 may help to draw and thin the beverage medium 42 flow, thereby helping to increase the surface area of the beverage medium exposed to the liquid.", "A mixing chamber may be arranged to help enhance this effect, e.g., by providing progressively elongated flow.", "In addition to potentially aiding mixing, providing a coaxial flow of precursor liquid and beverage medium may also help prevent contact of the beverage medium (which may be relatively more viscous) with a wall of a mixing chamber or other conduit, helping to reduce the chance of the beverage medium sticking to the wall.", "In fact, less viscous material (precursor liquid) may be directed to the walls of a mixing chamber or other conduit with more viscous material (beverage medium) located away from the walls.", "In addition, or alternately, a less viscous material may be introduced into a mixing chamber to wet the walls of the mixing chamber prior to introduction of beverage medium, e.g., to help prevent sticking of beverage medium to the chamber wall.", "The embodiment of FIGS.", "17-20 also includes a third portion 62, located below the second portion 47 and the support 72.Precursor liquid introduced via the precursor liquid inlet 47a and beverage medium 42 forced from the second portion 47 may enter into the third portion 62, e.g., for thorough mixing, foam production, or other processing to create a beverage.", "In this embodiment, the third portion 62 includes a funnel shape, e.g., to induce a swirling motion of the precursor liquid and beverage medium to help with mixing, but could be arranged in other ways.", "For example, the third portion 62 may include an eductor (e.g., to entrain air, liquid or other materials in a beverage), ajet (e.g., to increase the speed of beverage medium flow and/or contact with surrounding air), a flow straightener (e.g., to help output the beverage from the cartridge in a predictable and desired way), and others.", "Like the first portion 46, the third portion 62 may be formed unitarily with the support 72 or may be made as a separate component and joined to the support 72.Of course, the third portion 62 is not required for the cartridge, e.g., where a beverage making machine that uses the cartridge 4 includes a mixing chamber or other feature.", "While FIGS.", "17-20 show an arrangement in which the first and second portions 46, 47 are offset from each other, other configurations are possible.", "For example, FIG.", "23 shows a cross sectional view of a cartridge similar to that in FIGS.", "17-20, but with the first chamber 46 located directly below the second portion 47.In addition, the first portion 46 may be arranged around a portion of a third chamber 62, e.g., to help make the cartridge more compact.", "Thus, the cartridge in FIG.", "23 may incorporate aspects of the invention regarding having a second portion 47 above a plane and a first portion 46 below the plane, as well as having the first portion 46 surround a part of the third portion 62.As with the cartridge of FIGS.", "17-20, the cartridge in FIG.", "23 may include a sidewall that extends around the periphery of the cartridge 4, e.g., to make the cartridge 4 easier to handle by a user, to help protect portions of the cartridge 4 from damage, and/or help orient the cartridge 4 properly when associated with a beverage making machine.", "The arrangements of FIGS.", "17-23 may include other physical features, such as features that help ensure proper orientation and placement of the cartridge 4 when associated with a beverage making machine.", "For example, the cartridge of FIGS.", "17-23 may include a vertical sidewall that extends around the support 72, e.g., forming a wall around the other cartridge 4 portions.", "The configuration may help protect cartridge components from damage (e.g., accidental piercing of the second portion 47), help make handling of the cartridge easier (e.g., allow the cartridge to be placed on a table without rolling), and/or help properly orient the cartridge with respect to a beverage machine.", "In another aspect of the invention, a second portion of a cartridge may include two or more sub-portions that each hold a corresponding volume of beverage medium 42.The cartridge may operate so that a controllable number of the sub-portions is caused to deliver its corresponding charge of beverage medium, e.g., to allow for different amounts of beverage medium to be used in making a beverage, to provide for staged release of different beverage media (e.g., flavoring beverage medium may be released prior to a foaming medium so that the resulting beverage has a foam provided on the top of the beverage), to accommodate the separation of incompatible components (e.g., components that do not mix well with each other or react together in an undesirable way prior to beverage formation), or others.", "For example, the second portion 47 in the FIG.", "23 embodiment may include two or more pouches formed inside of the second chamber 47, e.g., that are separated from each other by a frangible impermeable membrane.", "Thus, a plunger of the beverage making machine may depress the second portion 47 a corresponding amount to cause delivery of a suitable number of the sub-portions.", "For example, the sub-portions may be stacked and separated by respective membranes like layers of a cake.", "Initial depression of the second portion 47 may cause a lowermost sub-portion to open and deliver its contents.", "Further depression by the plunger may cause a next sub-portion to open and deliver its contents and so on.", "In this way, any desired number of sub-portions may be deployed, or not, as optionally set by a user of the machine itself.", "By having separated sub-portions, less than all of the beverage medium in a cartridge may be used to form a beverage while minimizing leakage of the unused beverage medium when the cartridge is removed from the beverage making machine.", "In another aspect of the invention, a first portion of a cartridge may move relative to a second portion to force beverage medium to exit from the second portion.", "For example, FIGS.", "24-27 show an exploded view, a perspective view, a cross-sectional view with a beverage medium in a second portion, and a cross-sectional view with beverage medium expelled from the second portion of a cartridge, respectively, in which a first portion may act as a plunger to drive beverage medium from a second portion of the cartridge.", "The first portion 46 may be defined at least in part by a first chamber wall, e.g., a cup-shaped element that is received into the second portion 47.The second portion may be defined at least in part by a second chamber wall that defines a second space, e.g., where beverage medium is located.", "The first chamber wall of the first portion 46 may be received into the second space and be movable relative to the second chamber wall to expel beverage medium from the second portion of the cartridge.", "For example, FIGS.", "26 and 27 show how the first portion 46 may be moved downwardly relative to the second portion 47 so that the first portion is further received into the second portion to force beverage medium from the second portion.", "In essence, the first portion 46 may function as a plunger in the second space of the second portion 47 to force beverage medium 42 to the outlet of the second portion.", "Movement of the first portion 46 relative to the second portion 47 may be caused in any way, such as by a beverage making machine including a motor drive that moves the first portion 46, introducing gas pressure (e.g., created by the gas source 41) into a bladder that expands to cause movement of the first portion 46, moving the second portion 47 upwardly relative to the first portion 46 (which may remain stationary relative to the machine), and so on.", "Also, the cartridge 4 may include a lock element that prevents relative movement of the first and second portions 46, 47 until released by a user and/or a beverage making machine.", "The second portion 47 may include an outlet closure at the beverage medium outlet 47b that opens in response to increased pressure in the second portion 47, in response to piercing, mechanical fracture, etc.", "Thus the outlet 47b of the second portion 47 may open in any suitable way to allow for beverage medium 42 to exit the second portion 47.Another aspect of the invention incorporated into this embodiment is that a mixing chamber portion of the cartridge (a third portion) may partially surround the first and second portions 46, 47.Such an arrangement may help to make the cartridge 4 more compact, as well as provide a larger space in which precursor liquid and beverage medium can move to help with mixing.", "In addition, when coupled with an arrangement in which the first portion is received in the second portion, the overall size of the cartridge may be reduced, particularly after use of the cartridge.", "It is also possible to make the third portion reusable, e.g., a user could remove and clean the third portion as needed, and replace the first and second portions for each new beverage to be made.", "This feature may help reduce waste, yet provide the user with the ability to replace a third portion used with the cartridge only as needed.", "In this embodiment, the third portion 62 is arranged with vanes, fins or other features to help induce movement of precursor liquid and beverage medium, e.g., to help with mixing.", "However, other arrangements are possible.", "(As with any features described herein, the use of vanes, fins or other features to help induce mixing may be used with any suitable cartridge configuration.)", "Moreover, different arrangements for the third portion 62 may be provided for different beverages.", "For example, highly carbonated beverages made with readily dissolvable beverage media may have the third portion arranged to induce little movement, e.g., to help reduce loss of carbonation due to turbulent motion of the liquid.", "However, with other beverages, such as hot chocolate, more turbulent motion may be induced in the third chamber to help with mixing, and with no concern for loss of carbonation (since the beverage is not carbonated).", "Thus, a beverage making machine may be configured to make a wide variety of hot, cold, carbonated, still and other beverages by, at least in part, providing different cartridge arrangements.", "Close proximity of the gas source 41 and the beverage medium 42 in a cartridge 4 may provide the cartridge 4 with the ability to control or use heat generated by the gas source 41.For example, heat emitted by a zeolite gas source material during gas release may be absorbed by a beverage medium 42.In the case where the beverage medium 42 is a relative viscous liquid at lower temperatures, heating of the beverage medium 42 by the gas source 41 may reduce the viscosity of the beverage medium and enhance its dissolution into precursor liquid.", "In addition, or alternately, receipt of heat by the beverage medium 42 or other portion of the cartridge 4 from the gas source 41 may help prevent or otherwise resist excessive heat buildup in the cartridge 4.This may help reduce the risk of heat damage to the cartridge and/or help the gas source 41 emit gas more efficiently, e.g., where high heat levels may inhibit gas release.", "In another aspect of the invention, a cartridge may be arranged to have a gas outlet and a beverage medium outlet on a same side of the cartridge container.", "In some embodiments, the cartridge may further have an activator inlet through which fluid is provided to activate a gas source and/or a precursor liquid inlet through which precursor liquid is introduced into the container for mixing with the beverage medium on a same side of the container as the gas outlet and the beverage medium outlet.", "Such an arrangement may make for a conveniently handled and used cartridge.", "For example, by providing inlet(s) and outlet(s) on a same side of the cartridge, an interface between the beverage making machine and the cartridge may be simplified.", "For example, in some cases, a cartridge may be simply plugged into or otherwise associated with the beverage making machine in a simple way with needed connections made in one local area on a single side of the cartridge.", "FIGS.", "28-30 show an illustrative embodiment of a cartridge that includes a gas outlet, beverage medium outlet, activator inlet and precursor liquid inlet all located on a same side of the container.", "While a cartridge having these features may be arranged in other ways, in this embodiment, first and second portions 46, 47 of the cartridge container are formed by a pair of layers of barrier material 79, e.g., a foil laminate, that are joined together to form a pair of pouches for the first and second portions 46, 47.Of course, the container could be arranged otherwise, e.g., by a molded plastic body that defines the first and second portions 46, 47 with a shape like that shown in FIG.", "28.The layers of barrier material 79 are bonded together to form the first and second portions 46, 47, and are also joined to an insert 74 that defines, at least in part, the gas outlet 46b, activator inlet 46a, precursor liquid inlet 47a and beverage medium outlet 47b.", "The insert 74 in this embodiment includes a pair of molded plastic parts arranged to not only define the inlets/outlets, but also to enhance bonding of the barrier layers to the insert 74.For example, an inner part of the insert 74 may be bonded to the barrier material 79, allowing the cartridge 4 to be provided with gas source 41 and beverage medium 42, and then the outer part of the insert 47 (which may define the inlet/outlet interfaces to the beverage making machine) to be engaged, closing the first and second portions 46, 47.However, other arrangements are possible, such as one in which the insert 74 is eliminated and the layers of barrier material 79 are pierced to form the inlets/outlets as needed, or a single piece insert 74.In this embodiment, the insert 74 is arranged to close the inlets/outlets, e.g., by a foil lid, and require piercing at each of the inlets/outlets to open the inlets/outlets.", "Alternately, one or more of the inlets/outlets may include a closure that can be opened by breaking off a tab, peeling a foil cover from the inlet/outlet, exposing the inlet/outlet to a suitable pressure threshold to cause the closure to burst or otherwise open, and so on.", "By forming the first and second portions 46, 47 in a side-by-side arrangements like that in FIGS.", "28-30, a surface area between the first and second portions 46, 47 may be reduced and/or have its moisture permeability reduced so as to reduce migration of moisture from the beverage medium 42 in the second portion 47 into the first portion 46.That is, if the beverage medium includes moisture (such as with some concentrated syrups), water may migrate from the beverage medium 42 and into the first portion 46, which may cause partial activation of a gas source 41 (if the gas source 41 is activatable by water).", "This may cause problems where a wall or other element separating the beverage medium 42 from the gas source 41 is relatively permeable.", "However, a side-by-side arrangement like that in FIGS.", "28-30 may allow for adjustment of the width of the barrier layer seal between the portions 46, 47, thereby controlling the permeability of the joint.", "Other arrangements may be used to reduce moisture migration between the first and second portions 46, 47 (or other cartridge portions), such as through a choice of materials, relative positions of the first and second portions 46, 47 (e.g., moisture is very unlikely to travel from the beverage medium 42 to the gas source in the embodiments of FIGS.", "12 and 17, for example, because of the physical separation of the portions), and so on.", "Another aspect of the invention incorporated into this embodiment is that the gas outlet 46b includes a conduit 46d that extends from the gas outlet, through the gas source part of the first portion (i.e., where the gas source 41 is located), through a filter 46c, and into the gas outlet part of the first portion.", "While in this embodiment the conduit 46d is formed by a tube, the conduit 46d could be formed by the barrier layers themselves, e.g., by joining the barrier layers in a way to form a conduit 46d.", "In accordance with another aspect of the invention and as can be seen in FIGS.", "28-30, the barrier layers are joined together in a pattern to form a filter 46c that helps to keep gas source materials 41 in a gas source part of the first portion and permits primarily gas to pass through the filter 46c to a gas outlet part of the first portion where the gas can enter the conduit 46d and pass to the gas outlet 46b.", "While the pattern in which the barrier layers 79 may be joined together to form the filter 46c can vary, in this embodiment, the barrier layers are joined at locations having a circular (or other suitable) shape that are separated from each other by a suitable distance and configuration to help prevent gas source materials 41 from passing between the joined areas.", "Other arrangements are possible for the filter 46c however, such as a piece of filter paper, a hydrophobic non-woven material that permits gas to pass, but resists liquid passage, or other element that permits gas to move toward the conduit 46d, but resists movement of gas source material and/or liquid.", "In addition or alternately to the filter 46c, the conduit 46d may include a filter element, such as a filter plug in the conduit 46d, to help further resist movement of gas source materials 41 from the gas outlet 46b.", "In accordance with another aspect of the invention, a conduit of the gas outlet 46b may extend from a bottom of the first portion 46 to a top of the first portion 46 without the presence of a filter 46c.", "Instead, gravity may be relied on to maintain gas source material 41 from traveling toward a top of the first portion 46 and entering the conduit 46d.", "Alternately, a filter in the conduit 46d (such as a plug mentioned above) may function to resist entry of gas source material into the conduit 46d.", "Thus, the distal end of the conduit at the upper end of the first portion 46 may receive emitted gas and conduct the gas to the gas outlet 46b.", "The way in which the barrier layers 79 are joined together to form the first chamber 46, e.g., including the filter 46c, may help to hold the gas source material 41 in a fixed bed arrangement.", "That is, the gas source 41 may be held relatively firmly, so that the gas source 41 does not freely move in the first portion 46.This may help with controlled wetting of the gas source 41, since the distribution of the gas source in the first portion 46 may be known, and the interaction of activating fluid with the gas source predictable and repeatable.", "The gas source 41 may be arranged to allow for free movement of gas through the fixed bed of materials, e.g., by sizing and shaping particles of gas source material so as to prevent extremely close packing.", "In another embodiment, rather than have the cartridge arranged to exert a force on the gas source 41 so as to form a fixed bed of material, an external force may be exerted on the first portion 46 to provide a fixed bed of material.", "For example, the air bladder arrangement discussed above may be used to squeeze the gas source 41 in the first portion 46, thereby preventing flowing of the gas source 41 in the first portion 46.In other cartridge embodiments, such as that in FIG.", "24, for example, the first portion 46 may include a component, such as a resilient sponge material or a permeable membrane that is positioned at the top of the gas source 41 and is attached to the wall of the first portion 46, to help keep the gas source 41 in a fixed bed arrangement.", "Another aspect of the invention incorporated into this embodiment is that the precursor liquid inlet 47a may include a conduit extending into the second portion 47 that is arranged to introduce precursor liquid into the second portion at multiple locations along the conduit.", "Such an arrangement, e.g., as can be seen in FIG.", "30, may help to better distribute the liquid in the second portion and mix the precursor liquid with the beverage medium which exits the second portion 47 via the beverage medium outlet 47b.", "Features may be provided to help prevent entry of beverage medium 42 into the conduit and its perforations or other openings, e.g., to help ensure even and predictable flow of precursor liquid into the second portion 47.For example, a perforated conduit may be sheathed in a frangible cover that separates the conduit from the beverage medium 42 prior to use, but breaks, dissolves or otherwise opens to permit entry of precursor liquid into the second portion 47.In another embodiment, the conduit may include a plug, filter or other component to help prevent ingress of beverage medium into the conduit and/or its perforations.", "As with the gas outlet conduit, the precursor liquid inlet conduit could be formed by the barrier layers, e.g., which may be joined to form a flow path extending along the length of the second portion 47, as well as to have multiple outlets along its length to help distribute fluid into the second portion 47.Such outlets may be formed to be closed prior to cartridge use, but may burst or otherwise open with the introduction of precursor liquid into the second portion 47.This arrangement may also provide the additional feature of allowing the second portion 47 to be squeezed flat to expel beverage medium.", "In yet another embodiment, the precursor inlet 47a may include a trouser valve, e.g., a flat, relatively flexible tube, that may be folded or rolled in the second portion prior to use of the cartridge.", "With introduction of precursor liquid into the inlet 47a, the trouser valve may unroll/unfold, allowing precursor liquid to enter the second portion 47.However, the rolled/folded configuration of the valve prior to deployment may help prevent the ingress of beverage medium into the precursor liquid inlet 47a.", "Another aspect of the invention relates to the arrangement that allows the second portion 47 to be squeezed or otherwise manipulated by an external force to cause beverage medium to be expelled from the beverage medium outlet 47b.", "This feature may be used whether or not precursor liquid is introduced into the second portion 47.For example, the cartridge may be modified to eliminate the precursor liquid inlet 47a, and instead, the second portion 47 may be squeezed to force the beverage medium 42 to exit via the beverage medium outlet 47b, e.g., for mixing with precursor liquid outside of the cartridge 4.Alternately, the second portion 47 may be squeezed after precursor liquid has been introduced into the second portion 47, e.g., to help remove liquid from the second portion and reduce dripping of the cartridge when removed from the beverage making machine.", "In yet another arrangement, a cartridge holder of a beverage making machine may apply a force to the cartridge that tends to squeeze the second portion 47 and expel beverage medium 42, but with a force or pressure that is less than a pressure of precursor liquid introduced into the second portion 47.Thus, the second portion 47 may expand to receive precursor liquid 2, but when precursor liquid 2 stops, the cartridge holder may squeeze the second portion 47 to substantially evacuate its contents.", "The cartridge holder may apply the squeezing force in any of a variety of ways, such as by employing an air bladder to which a suitable air pressure is applied to squeeze the cartridge in the cartridge holder.", "The force of the air bladder or other component may vary during use of the cartridge, e.g., to help with mixing and/or expulsion of beverage medium from the second portion 47.For example, a pressure applied to the bladder may be relatively high during an initial portion of the beverage making cycle to expel beverage medium from the second portion 47 and reduce the volume of the second portion 47.Thereafter, the pressure of the bladder may be released or otherwise reduced, allowing precursor liquid to be introduced into the second portion 47, enlarging its volume.", "Again, the pressure of the bladder may be increased to expel mixed liquid and beverage medium from the second portion 47, and reducing the volume of the second portion 47.This cycling of the bladder pressure may be repeated to effect better mixing in the second portion 47 and/or complete expulsion of beverage medium 42.Again, an air bladder is not required to perform this function, as other arrangements, such as a motor driven wall, plunger, roller, etc., may be used.", "In short, the cartridge may be manipulated by an external force prior to, during or after introduction of precursor liquid to help with mixing, expulsion of beverage medium, and/or reducing dripping of the cartridge after use.", "As mentioned above, the system schematics shown in FIGS.", "1-4 are only a few of the possible arrangements regarding a beverage making system 1.For example, FIG.", "31 shows another schematic diagram of a beverage making system 1 that may use any of the cartridge arrangements discussed herein or an alternate cartridge arrangement.", "In this embodiment, a reservoir 11 is arranged to provide precursor liquid 2 to a contactor 6 by gravity feed and/or gas pressure.", "Of course, other arrangements are possible for moving liquid from the reservoir 11 to the contactor 6, such as the use of a pump.", "Also, although a contactor 6 is shown in this illustrative embodiment and others discussed below, other carbonation or gas dissolving devices may be used instead, such as a carbonation tank.", "The system I of FIG.", "31 may operate as follows: valves VI and V2 may be opened, allowing delivery of liquid 2 to the first portion 46 of a cartridge 4 by gravity feed via the contactor 6.The liquid 2 may activate a gas source 41, which emits gas that is directed to the contactor 6.Some of the gas introduced into the contactor 6 may be dissolved in liquid 2 in the contactor 6, while another portion of the gas may be directed to the reservoir 11.Gas provided to the reservoir 11 may increase a pressure in the reservoir 11, forcing liquid 2 to flow toward the contactor 6.Pressure in the reservoir 11 may help to increase the overall carbonation level of the precursor liquid, e.g., by pre-carbonating the water as the reservoir 11 acts as a carbonation tank.", "Increased acidity of the liquid 2 in the reservoir 11 may also help reduce scale build up and/or bacterial growth in the reservoir.", "The pressure in the reservoir 11 may be controlled by controlling a valve V3 to control an amount of gas admitted into the reservoir 11.In addition, the valve V2 may be controlled to control the amount of liquid 2 that enters the first portion 46, thereby controlling activation of the gas source 41.The valve V2 may be operated to pass liquid 2 having a suitable amount of dissolved gas (e.g., carbonated liquid 2) to the second portion 47 of the cartridge 4 for mixing with beverage medium 42.Another valve may be provided to vent gas from the gas dissolution device (e.g., contactor 6) in this and other embodiments, if desired.", "An optional valve V4 may be opened to allow the formed beverage to flow to a waiting cup or other holder 8, and an optional valve may be opened to vent gas pressure from the gas side of the contactor 6.By feeding gas emitted by the gas source 41 to the reservoir 11, the system may be flushed of liquid, e.g., by the gas pushing liquid out of the reservoir 11, the contactor 6 and the second portion 47 of the cartridge 4.This may help prevent dripping of the cartridge 4 when it is removed from the system 1 and/or help prevent liquid from stagnating in the system 1 between uses.", "A volume of liquid used to form the beverage may be controlled by a user, e.g., by providing a desired amount of liquid into the reservoir 11, or by the system 1 itself, such as by a fill level sensor that operates to fill the reservoir 11 to a suitable level, by a flow meter that detects a volume of water delivered to the second portion 47, and so on.", "FIG.", "32 shows a schematic diagram of another beverage making system 1, which again, can be used with any suitable cartridge arrangement.", "In this embodiment, a reservoir 11 provides precursor liquid 2 to a contactor 6 under the control of a valve V4.Liquid 2 may flow into the contactor 6 by gravity, pump, gas pressure, etc., although in this embodiment gravity is employed.", "Liquid provided to the gas source 41 to activate the gas source 41 is controlled by a valve V1, which may control flow based on any suitable characteristic, such as elapsed time, a sensed gas pressure, a detected volume in the cartridge 4, etc.", "With suitable gas emitted by the gas source 41 and routed to the contactor 6, the valve V4 may be opened to permit now carbonated liquid or other liquid having dissolved gas to flow into the second portion 47 of the cartridge 4 for mixing with the beverage medium 42.Again, the liquid need not be routed to the second portion 47, but instead may be routed to a mixing chamber portion of the cartridge or other area where beverage medium is mixed with the liquid 2.Alternately, the liquid 2 may pass directly to the cup 8 where the liquid is mixed with a beverage medium.", "A valve V3 may be opened to allow beverage to flow from the cartridge 4 to the cup 8.At a suitable timing, e.g., before, during or after beverage formation, a valve VS may open to allow ice 2a to pass into the cup 8.The ice 2a may additionally serve to help cool the precursor liquid 2 in the reservoir 11 before passing to the cup 8.A filter or other separator may be employed in the reservoir 11 between the ice and the precursor liquid 2, e.g., to help reduce bacterial contamination of the precursor liquid 2 by the ice 2a.", "That is, ice 2a may be stored in the reservoir 11 in a compartment separate from the liquid 2, e.g., by a permeable or impermeable barrier, and delivered to the cup 8 upon opening of the valve VS.", "It should also be noted that any gas pressure in the contactor 6 may be vented by a valve or other suitable arrangement before, during or after beverage formation.", "FIG.", "33 shows another schematic diagram of a beverage forming system 1 that, like others, may be used with any suitable number and/or combination of aspects of the invention or other features.", "In this embodiment, the reservoir 11 may hold a volume of precursor liquid 2 equal to several beverages.", "Thus, the system 1 may make multiple beverages without requiring the addition of liquid to the reservoir 11.A pump 13 and valve V1 control the flow of liquid through a contactor 6 and to the second portion 47 of a cartridge 4.The gas source 41 may be activated in any suitable way to emit gas that is routed to the gas side of the contactor 6 under the control of a valve V2.For example, the gas source 41 may emit gas in response to being exposed to microwave energy, thermal heat energy, other electromagnetic radiation, liquid water or water vapor, etc.", "Gas emitted by the gas source 41 may be dissolved in the liquid 2 in the contactor 6, which may then be mixed with beverage medium 42 in the cartridge 4 or elsewhere.", "A valve V3 may control the flow of beverage from the system 1, e.g., through a nozzle which may be incorporated into the cartridge and may help to further mix the liquid and beverage medium, may help direct the beverage into a cup 8, may help to aerate or form a foam in the beverage, etc.", "Although FIGS.", "31-33 are described as involving the direction of all or substantially all of the precursor liquid 2 used to form a beverage through the cartridge 4, other arrangements are possible.", "For example, as discussed above, only a portion of the liquid 2 may be routed through the cartridge 4, e.g., to expel beverage medium 42 from the cartridge to the cup 8 (or other mixing chamber), while a remaining portion of the liquid 2 is routed directly to the cup 8 (or other mixing chamber).", "Also, a chiller circuit, e.g., including a thermoelectric device, refrigeration device, heat exchanger that employs user-supplied ice, or other arrangement, may be included in the system 1 to chill the precursor liquid 2 before, during and/or after gas dissolution, and/or before, during and/or after mixing of beverage medium with the precursor liquid.", "FIG.", "34 shows another illustrative embodiment of a beverage making system 1.In this embodiment, a reservoir 11 includes three portions, i.e., a main reservoir portion 11a, a gas source activating portion 11b and a pre-mix portion 11c.", "Initially the main reservoir portion 11a may be filled to a desired level, and the gas source activating portion 11b and the pre-mix portion 11c may be empty.", "At the start of a beverage formation cycle, a plunger 11d may be lowered into the main reservoir portion 11a, which causes a controlled amount of precursor liquid 2 to spill or otherwise be directed into the gas source activating portion 11b and the pre-mix portion 11c.", "Thereafter, as the plunger 11d is inserted further into the main reservoir portion 11a, the plunger 11d may form a seal with the main reservoir portion 11a, preventing any further amounts of liquid 2 from being passed into the gas source activating portion 11b and the pre-mix portion 11c.", "Further lowering of the plunger 11d (and with opening of the valve V1) may cause liquid 2 to pass from the main reservoir portion 11a through the contactor 6.In addition, liquid 2 in the gas source activating portion 11b may be forced through the (open) valve V2 and into the first portion 46 of the cartridge to activate the gas source 41.The valve V2 may control an amount of liquid passed to the first portion 46, e.g., to control an amount and/or pressure of gas emitted, provided that with the valve V2 closed, liquid in the portion 11b is permitted to exit with movement of the plunger 11d so as not to resist its movement.", "A pressure of gas emitted by the gas source that is passed to the contactor 6 may be additionally, or alternately, controlled by a pressure regulating valve V4.Thus, a desired gas pressure may be maintained in the gas side of the contactor 6.Liquid 2 in the pre-mix portion 11c may also be forced to flow into the second portion 47 of the cartridge 4 to mix with beverage medium 42.Mixing of the liquid and medium may be complemented by physical disturbance of the materials in the second portion 47, such as by kneading of the second portion 47 (e.g., by a roller or other element), stirring, shaking, etc.", "This may help to pre-mix the beverage medium 42, and make later mixing with additional precursor liquid 2 more effective.", "With valve V3 open, pre-mixed beverage medium 42 may pass into a mixing nozzle or other chamber (e.g., which may be part of a third portion 62 of the cartridge 4 or a part of the beverage making machine), while liquid 2 having dissolved gas from the contactor 6 may also be introduced into the mixing nozzle.", "(Note that the valve V3 in this and other embodiments may include a valve that is incorporated into the cartridge 4, such as a burst valve, duckbill valve, split septum, or other.", "The mixed precursor liquid 2 and beverage medium 42 may then be routed to a waiting cup 8 or other container.", "FIG.", "35 shows another illustrative embodiment of a beverage making system 1 that, like those embodiments discussed above, incorporates one or more aspects of the invention.", "This illustrative embodiment includes a pair of syringe pumps 13a, 13b that are arranged to cause precursor liquid 2 to flow from one pump 13, through the contactor 6 and into the other pump 13, and vice versa.", "In this way, the system 1 can pass precursor liquid 2 through the contactor 6 one or more times, e.g., to increase an amount of dissolved gas in the precursor liquid 2, as desired.", "Of course, the system 1 could achieve multiple passes through a contactor or other gas dissolving device in other ways, such as by a single pump that directs liquid to flow from a reservoir 11, through a contactor 6 and back to the reservoir 11.However, in this embodiment, the syringe pump 12a is arranged to draw precursor liquid 2 from a cup 8 or other container through a valve V1.Thus, a user may place a cup 8 containing a desired volume or type of precursor liquid 2 in association with the system 1, and the system 1 may use the precursor liquid 2 in the cup 8 to form a beverage.", "A filter at the valve V1 or elsewhere may help reduce a number of bacteria or other organisms that enter the system 1, helping to reduce potential system contamination.", "Also, the syringe pump 13 or other pump arrangement may be configured to aspirate a suitable volume of liquid 2 from the cup 8, e.g., by controlling a stroke length of the syringe piston, by detecting flow with a flow meter, by detecting a liquid level in the pump or other reservoir, etc.", "With the precursor liquid 2 aspirated into the first syringe pump 13a, the valve V1 may be closed, and the valve V2 opened to so that the pump 13a can force the liquid 2 into the contactor 6.", "(While FIG.", "35 shows there may be gas as well as liquid 2 in the pump 13a, it may be the case that no gas is present in the pump 13a.)", "Meanwhile, the valve V2 (or another valve) may allow some liquid 2 to flow into the first portion 46 of a cartridge 4 to activate a gas source 41.Thus, liquid may dissolve gas emitted by the gas source 41 as the liquid 2 passes through the contactor 6.The valve V3 may be arranged to allow the liquid 2 flowing from the contactor 6 to enter the second syringe pump 13b for temporary storage therein.", "With a desired amount of liquid transferred from the first syringe pump 13a to the second syringe pump 13b via the contactor 6, flow may be reversed with the second syringe pump 13b causing flow through the contactor 6 and to the first syringe pump 13a.", "This cycling may be repeated a desired number of times, e.g., based on the output of a carbonation detector, to achieve a desired level of carbonation of the liquid 2.With carbonation or other gas dissolving complete, the valve V3 may be arranged to pass liquid 2 to the second portion 47 of the cartridge, e.g., for mixing with beverage medium 42 and transfer of beverage (via open valve V4) to the cup 8.A system like that in FIG.", "33 may allow a user to define a carbonation or other dissolved gas level for a beverage, and may operate to dissolve gas into the precursor liquid 2 up to the set level, whether before or after mixing beverage medium with the precursor liquid 2.In another aspect of the invention, a cartridge may be arranged to control a flow of activation fluid into the cartridge to activate a gas source.", "As discussed above, one option is to have a beverage making machine control flow of activation fluid into the cartridge.", "However, the cartridge itself may also help to control activation of the gas source.", "Such an arrangement may allow the cartridge itself to define a carbonation or other gas dissolution level, allowing different cartridges to define different gas dissolution levels without requiring a change in system operation.", "For example, FIG.", "36 shows a schematic view of a first portion 46 of a cartridge 4 that includes a flow controller 76 in the form of a valve (such as a pressure regulator or pressure activated valve).", "Activation fluid (e.g., water) may be provided at the activator inlet 46a under a set pressure.", "When a pressure in the first portion 46 is suitably low, the flow controller 76 may open to allow water to enter the first portion 46, which causes activation of the gas source 41.However, once pressure in the first portion 46 reaches a threshold level, the flow controller 76 may close, stopping flow of water into the first portion 46.This stop in flow will tend to lower the pressure in the first portion 46 as gas is routed to a contactor or other gas dissolution device or vented, and when the pressure again drops suitably, the flow controller 76 may again open.", "In this embodiment, the flow controller 76 is shown to include a spring that urges a valve gate to close, where the force of the spring is set to provide suitable gas pressure control in the first portion 46.However, other arrangements are possible, such as those found in pressure regulator valves, an arrangement in which high pressure in the first portion 46 tends to expand a part of the cartridge to pinch (and thereby close) a flow path from the activator inlet 46a, and so on.", "FIGS.", "37 and 38 show another illustrative embodiment in which a cartridge 4 includes a flow controller 76 similar to that in FIG.", "36.However, in this embodiment, the flow controller 76 (specifically an upstanding strut functioning as a spring element) interacts with a part of the beverage making machine.", "Thus, when the cartridge 4 in this embodiment is properly associated with the beverage making machine, the flow controller 76 may be caused to operate to control activation fluid flow into the cartridge.", "Other arrangements similar to that in FIGS.", "37 and 38 are possible, including arrangements in which the beverage making machine may control the opening and closing of a flow controller 76 of the cartridge 4.For example, the arrangement in FIGS.", "37 and 38 may be modified so that the beverage making machine moves the strut or other portion of the flow controller 76 (such as a valve gate) to cause the flow controller 76 to open and close.", "Other flow controller arrangements are possible in such an embodiment, such as a membrane valve, flapper valve, plunger valve, etc., which may be manipulated and controlled by the beverage making machine.", "FIGS.", "39-42 show another illustrative embodiment of an arrangement for controlling activation fluid flow into a cartridge.", "In this embodiment, the cartridge 4 has an arrangement similar to that in FIGS.", "38-30.The cartridge is shown in FIGS.", "39 and 40 in a mounted orientation in a beverage making machine.", "An activation fluid inlet needle or other port extends into an activator inlet 46a of the cartridge and remains stationary during beverage formation.", "In addition, a part of the cartridge 4 near an upper end is held fixed relative to the fluid inlet needle.", "When a pressure in the cartridge 4 is relatively low, a distal end of the inlet needle is positioned relative to the activator inlet 46a of the cartridge 4 so that activation fluid is delivered to the cartridge 4.However, when a pressure in the cartridge increases, the cartridge expands, pulling the activator inlet 46a away from the inlet needle.", "This movement stops flow of activation fluid, which does not resume until pressure drops in the cartridge and the cartridge moves to the orientation shown in FIG.", "39.FIGS.", "41 and 42 show one arrangement of the fluid inlet needle and the activator inlet 46a for this embodiment.", "The inlet needle has an opening on its side so that when the needle extends into the cartridge 4, the activation fluid flow path is open.", "However, withdrawal of the inlet needle into the activator inlet 46a blocks the flowpath, stopping activation fluid flow.", "Other arrangements for opening and closing an activation fluid flowpath based on cartridge movement are possible, such as a valve in the activator inlet 46a that opens and closes based on cartridge movement or pressure change, and others.", "FIGS.", "43 and 44 show another arrangement for controlling activation fluid control.", "In this embodiment, the cartridge again has an arrangement similar to that in FIGS.", "28-30.When activation fluid is provided to the cartridge and the gas source is activated (as shown in FIG.", "43), the cartridge will generate gas, which causes a pressure build up and enlargement of the cartridge 4 (as shown in FIG.", "44).", "An increase in size of the cartridge in at least one portion may activate a switch or other sensor 51, which causes the system controller 5 to stop activation fluid flow to the cartridge 4.When the pressure reduces, the cartridge may reduce in size and the switch or other sensor 51 will be deactivated, allowing activation fluid flow to resume, if appropriate.", "FIG.", "45 shows yet another embodiment, again with an arrangement similar to that in FIGS.", "28-30.However, in this embodiment, the gas outlet conduit 46d and the precursor inlet 47a conduit are both formed by suitable weld lines joining the layers of barrier material 79.That is, the conduits for gas outlet and precursor inlet into the first and second portions 46, 47, respectively, are formed by the barrier layers 79 only, and do not include a tube or other structure.", "As a result, flow of activation fluid and/or precursor liquid into the cartridge may be controlled by pinching the cartridge 4 so as to close one or both of the inlets 46a, 47a.", "It should be understood that the outlet of gas and/or beverage medium from the cartridge may be similarly controlled.", "Flow control may be based on any suitable criterion, such as a detected gas pressure, an elapsed timer, detected movement of the cartridge or portions of the cartridge (e.g., caused by a pressure increase in the cartridge), and so on.", "FIG.", "46 shows yet another illustrative embodiment regarding control of flow of activation fluid into a cartridge.", "In this embodiment, the cartridge 4 has an arrangement like that in FIG.", "23, and has a flexible wall or other part at the first portion 46 of the cartridge.", "As a result, when pressure in the first portion 46 increases to or beyond a threshold level, the flexible wall may expand outwardly.", "Movement of the cartridge wall or other part may be detected by the beverage making system 1, such as by a switch or other sensor 51.In response, the controller 5 may stop flow of activation fluid into the cartridge 4 until pressure in the first portion 46 is reduced, and the movable part of the cartridge retracts or otherwise moves to indicate a suitable drop in pressure.", "While in this embodiment, the movable part that indicates pressure in the first portion includes a flexible wall, other configurations are possible, such as a movable piston or plunger, etc.", "FIGS.", "47 and 48 show yet another embodiment regarding control of activation fluid in a cartridge.", "In this embodiment, the cartridge includes a flow controller 76 in the form of a valve that may be pinched closed by a valve actuator 81 of the beverage making system 1.In this embodiment, a pressure in the cartridge may be sensed by a sensor 51 that detects a pressure in a line leading from the first portion 46.If a suitably high pressure is detected, the system 1 may cause the valve actuator 81 to move so as to pinch the valve of the flow controller 76 closed.", "With a pressure at or below a threshold detected, the valve actuator 81 may allow the valve to open.", "While in this embodiment the valve of the flow controller 76 is a relatively simple structure in which a portion of the cartridge 4 may be moved to close a flow path (e.g., as in the embodiment of FIG.", "45), other arrangements are possible, such as valves with movable valve gates, plungers, or other structures that may be actuated by a valve actuator.", "For example, the flow controller 76 may include a membrane valve in which an impermeable membrane may be moved toward and away from a port so as to control flow into the first portion 46.FIGS.", "49 and 50 show an illustrative embodiment in which a cartridge may control flow of activation fluid into the cartridge 4 independent of a beverage making machine, e.g., like that in FIG.", "36.In this embodiment, the cartridge includes a flow controller 76 that includes a valve that can be opened and closed by pressure in the first portion 46.Thus, the flow controller 76 may include a pressure regulator-type valve that autonomously controls pressure in the first portion 46 to be within a desired pressure range.", "In FIG.", "49, pressure in the first portion is within or below the desired pressure range, and so the valve is open to allow the inflow of activation fluid into the first portion 46.In FIG.", "50, the pressure in the first portion 46 has risen above the desired pressure range, and as such, pressure on the right side of the valve (which is fluidly connected to the first portion 46) causes the valve to move to the left, stopping flow of activation fluid.", "In some embodiments, the pressure in the first portion as controlled by the flow controller 76 can vary depending on the pressure of incoming activation fluid.", "That is, the flow controller 76 could be arranged so that the pressure of the activation fluid influences the operation of the valve, e.g., in one case, so that the pressure in the first portion 46 must exceed the pressure of the incoming activation fluid to allow the flow controller valve to close and stop flow.", "This arrangement may allow the system 1 to operate different cartridges at different gas pressures in the first portion 46, e.g., by adjusting a pressure of the incoming activation fluid.", "However, in other embodiments, the flow controller 76 operation may be made independent of the pressure of the activation fluid so that variations in activation fluid pressure have no effect on the controlled pressure in the first portion 46.Such an arrangement may be useful, for example, where a pump delivering activation water has a variable pressure, and/or where pressure control in the cartridge is desirably influenced by ambient pressures, such as where operation of the system 1 at sea level requires higher gas pressures, but operation at high elevation requires lower pressures.", "Possible valve configurations for the flow controller 76 are generally known in the art, and are not described in detail herein.", "Also, the flow controller 76 may operate in a binary fashion (on/off) or may provide for variable flow rates.", "In another aspect of the invention, a cartridge may include a filter in the first and/or second portion to separate an inlet from an outlet of the first and/or second portion.", "For example, a filter may be provided in a first portion of a cartridge to help resist exit of gas source materials from the first portion.", "A filter may be provided in a second portion of a cartridge to help prevent relatively large, undissolved particles from clogging the outlet, help prevent bacterial contamination of a beverage (e.g., where the precursor liquid includes organisms that can be filtered from the precursor liquid prior to being supplied as a beverage), and/or help distribute precursor liquid in the second portion (e.g., to help with dissolution).", "FIG.", "51 shows a cartridge with an arrangement similar to that in FIG.", "45, but this embodiment includes a filter 46c in the first portion, and a filter 77 in the second portion 47.While in this embodiment the filter 46c and 77 are formed by a single filter element that spans the first and second portions 46, 47, other arrangements are possible, such as individual filter elements for each portion.", "The filter 46c may operate to restrain the passage of gas source materials to the gas outlet 46b, while the filter 77 may help reduce microbial contamination of the beverage medium and beverage, and/or help spread the flow of precursor liquid over a larger surface area of the beverage medium.", "FIGS.", "52-54 show another illustrative arrangement of a filter used in a cartridge like that of FIG.", "51.In this embodiment, a layer of perforated or otherwise suitably permeable material is interposed between the layers of barrier material 79 so that the activator inlet 46a is separated from the gas outlet 46b by the permeable material (which forms a filter 46c in the first portion 46), and the precursor liquid inlet 47a is separated from the beverage medium outlet 47b by the permeable material (which forms a filter 77 in the second portion 47).", "Again, the filters 46c and 77 could be formed in other ways, as this is just one of several possible embodiments.", "FIGS.", "53 and 54 show how the filters 46c and 77 separate the inlets and outlets of the respective first and second portions 46, 47.In FIG.", "53, it can be seen how the filter 77 provides a space into which precursor liquid may enter the second portion 47 and permeate through the filter 77 and uniformly wet the beverage medium 42.In FIG.", "54, it can be seen how the filter 46c provides a relatively large surface area for emitted gas to pass through the filter 46c and to the gas outlet 46b.", "FIG.", "55 shows a perspective view of how a single piece of permeable material can form the filters 46c and 77 in a cartridge like that in FIGS.", "52-54.As can be seen, the permeable material can traverse a zig-zag path relative to the inlet 46a, 47a and outlets 46b, 47b of the first and second portions 46, 47.To maintain the permeable material in the position shown in FIG.", "55, the permeable material may be bonded to the insert 74 and/or the barrier material 79 to keep the inlets/outlets clear.", "As discussed above, a cartridge may be configured to allow a user to interact with the cartridge to define one or more characteristics of a beverage to be made.", "For example, a user may interact with a cartridge to define a carbonation level, a sweetness of the beverage, an amount of beverage medium to use in making the beverage, and so on.", "FIGS.", "56 and 57 show an arrangement of a cartridge that is similar to that in FIG.", "45 but includes a clip 78 that can be engaged with the cartridge 4 so as to limit an amount of beverage medium 42 that can be used to form a beverage.", "The clip 78 may be movable relative to the cartridge to provide a continuously adjustable amount of beverage medium that can be used.", "A similar feature could be used to define an amount of carbonation, e.g., by limiting what portion of the gas source is exposed to activating fluid.", "Of course, a clip 78 is only one example of how a user could interact with a cartridge to define beverage characteristics.", "For example, the cartridge may have one or more removable tabs, adjustable sliders, holes or other features that can be removed or covered, etc., that could be adjusted by a user.", "The system controller 5 may recognize the adjusted feature and control the system 1 accordingly.", "Alternately, the adjusted cartridge feature may itself directly control operation of the system.", "For example, a broken off tab of the cartridge may trigger a switch that disables delivery of activating fluid to the cartridge, thereby forcing the machine to make a non-sparkling (or still) beverage.", "In another aspect of the invention, a cartridge may include a beverage outlet that extends from the cartridge, e.g., towards or to a user's cup or other container.", "Such an extending outlet may help deliver a beverage to a cup in splash-free way, may help reduce loss of carbonation or other dissolved gases, and/or may help reduce contact of the beverage with a beverage making machine.", "In one illustrative embodiment, the cartridge may include a trouser valve that includes two flat, elongated membranes sealed at opposing edges of the membranes along their length.", "The trouser valve may be folded or rolled up such that the folds or contact pressures in the rolled position close the valve, if necessary.", "In one embodiment, a relatively lightweight film can be used, e.g., to help the valve form a suitable seal when rolled or folded.", "When pressure is applied to the inner end of the trouser valve, the structure may unfold/unroll and expand into an elongated form.", "The extension of the trouser valve into a dispensing configuration may open any seal formed by the valve in its folded state and allow beverage to flow along the valve.", "The valve may be arranged to provide for smooth flow of the beverage through a tapered passageway, potentially reducing the risk of turbulence and loss of carbonation before dispensing.", "In other embodiments, a cartridge may include a more rigid outlet conduit that extends from the cartridge to conduct beverage toward a user's cup.", "For example, a retractable tube in the cartridge may extend under pressure built up in the cartridge.", "If desired, additional mixing action can be included in the beverage outlet flow path, e.g., by shaping the welds of a trouser valve to make the flow path serpentine or to include obstacles to enhance mixing of.", "Also, since a trouser valve may assume a flat condition after delivery of beverage, e.g., due to resilience of material used to make the valve that causes the valve to fold, the beverage outlet may retain little or no residual beverage, at least as compared to a cylindrical conduit of equivalent length.", "This may reduce leakage from the cartridge after use, reducing mess.", "In another aspect of the invention, a cartridge (such as a mixing chamber portion) may include a mixer or other movable part that interacts with beverage medium and/or precursor liquid to enhance mixing of the beverage.", "For example, the movable part may be actuated by interaction with flow of the beverage medium or precursor liquid, such as a vibrating reed, rotating blade, or other element.", "In another embodiment, the movable part may be actuated by an external drive, such as a direct drive shaft of a motor associated with a beverage making machine, a magnetic coupling that provides contact-free movement of the mixer or other movable part, a pneumatic or hydraulic drive that provides moving fluid to the cartridge to drive the mixer, and others.", "FIGS.", "58-60 show assembled, side and top views of another illustrative embodiment of a cartridge 4 that incorporates one or more aspects of the invention.", "As can be seen in FIG.", "58, the cartridge 4 in this embodiment includes a container with a first portion 46 and a second portion 47 that can be assembled so that the lids 45a, 45b of the portions 46, 47 are adjacent each other.", "For example, the first portion 46 may be arranged so that a part of the lid 45a is recessed below an upper edge of a rim 462 of a first container part 461 of the first portion 46.The rim 472 of the second container part 471 of the second portion 47 may be arranged to fit within the recess and engage with the rim 462 so as to hold the first and second portions 46, 47 together.", "For example, the rim 462 may include a groove that receives the rim 472 to releaseably hold the first and second portions 46, 47 together by a friction or interference fit, e.g., so that a user may pull the first and second portions 46, 47 apart by hand and without tools.", "Alternately, the first and second portions 46, 47 may be held together in an assembled position shown in FIG.", "58 by an adhesive, an overwrap film, a band of shrink-wrapped material at the junction between first and second portions 46, 47, a piece of tape or band that extends from the first portion 46 to the second portion 47, etc.", "Thus, in accordance with an aspect of the invention, the first and second portions 46, 47 may be arranged so that the cartridge has a plane where the first portion 46 is located below the plane and the second portion 47 is located above the plane.", "In this case, the plane of the cartridge may be parallel to, and defined by, a portion of the lid 45a, 45b, or may be parallel to a planar portion of a part of the lid 45a or 45b.", "The first and second portions 46, 47 may be used with a beverage making machine in the assembled condition, or may be moved relative to each other, e.g., separated from each other, for use with a beverage making machine.", "As discussed above, the first and second portions 46, 47 may be oriented in different ways for interacting with a beverage making machine, such as in a side-by-side configuration shown in FIG.", "59.In this embodiment, the first and second portions 46, 47 are not connected in FIG.", "59, but the first and second portions 46, 47 may be connected by a tether or other structure, e.g., like that shown in FIGS.", "6-8.Such a connection may help properly orient the portions 46, 47 for interaction with the beverage making system.", "In accordance with another aspect of the invention, the first and second portions 46, 47 are separated by an impermeable barrier, e.g., the lid 45a or the lid 45b, which in this embodiment are both impermeable (although both need not necessarily be so).", "Also, as shown in FIG.", "60, the lids 45a, 45b of the first and second portions 46, 47 may be arranged to accommodate a piercing element for inlet and/or outlet of gas or other fluids.", "For example, the lid 45a may have an inlet region 451 arranged to accommodate piercing by a piercing element (e.g., a needle, blade, etc.)", "to admit activating water, water vapor or other fluid into the first portion 46 to cause the gas source 41 to release carbon dioxide or other gas.", "The lid 45a may also have an outlet region 452 arranged to accommodate piercing to allow gas or other fluid to exit the first portion 46.However, as mentioned above, the lid 45a may be pierced in the same location for fluid inlet/outlet, or may not be pierced at all, e.g., where the lid 45a includes a defined port for inlet/outlet, or other portions of the first container part 461 are pierced at the bottom, sidewall or elsewhere.", "The lid 45b may have an inlet region 451 arranged to accommodate piercing to admit activating water, gas or other fluid, whether for mixing with the beverage medium 42, or to push the medium 42 to exit the second portion 47, e.g., through a pierced hole in the bottom of the second portion 47 for mixing with a precursor liquid in a user's cup, a mixing chamber, etc.", "The second portion 47 may also include a filter component 48b to help keep beverage medium 42 from contacting a piercing element that pierces the lid 45b.", "The filter component 48b may include a hydrophobic membrane, a piece of filter paper, or other suitable component, and may be attached to the lid 45b or other portion of the second container part 471.By avoiding contact of beverage medium 42 with a piercing element, unwanted contamination of the piercing element may be reduced or eliminated.", "Alternately, or in addition, a piercing element (whether used to pierce an inlet and/or outlet opening of a first or second portion 46, 47) may be arranged to be removable from a beverage making machine (e.g., for cleaning and replacement in the machine).", "Another possibility is to arrange the second portion 47 so that it can be squeezed, crushed or otherwise have a wall (such as the lid 45b or container part 471 sidewall) moved to urge beverage medium 42 to exit the second portion 47, e.g., through a burstable or otherwise frangible outlet or pierced hole.", "For example, the lid 45b may be pressed downwardly in the orientation shown in FIG.", "59 so that beverage medium 42 is forced out of the second portion 47, e.g., through an opening in a bottom part of the second portion 47.Such pressing may be accomplished by a plunger or piston of a beverage making machine that presses downwardly on the lid 45b, crushing the second portion 47 and expelling the beverage medium.", "The lid 45a (or the lid 45b) may have a pull tab (e.g., as shown in FIG.", "60) to aid a user in removing the lid 45a for recycling or other purposes.", "For example, a user may wish to remove the lid 45a from the first container part 461 to remove the gas source 41 after use.", "The gas source 41 may be contained in a permeable bag or other holder, such as a plastic mesh bag, filter paper pouch, etc.", "This bag may help prevent gas source 41 particles from exiting the first portion 46 and/or make removal and disposal/recycling of the gas source 41 materials in the first portion 46 easier.", "The bag may also help orient or otherwise position the gas source 41 in the first portion 46, e.g., to keep the gas source 41 away from the lid 45a (such as to avoid contact with a piercing element), to arrange the gas source 41 for optimal or other desired receipt of activating liquid (e.g., arrange the gas source 41 in layers or compartments for selective wetting), and so on.", "FIGS.", "61 and 62 show another illustrative embodiment of a cartridge 4 that incorporates one or more aspects of the invention.", "In this illustrative embodiment, similar to that of FIG.", "58, the first and second portions 46, 47 may be arranged on opposite sides of a plane, such as a plane that is parallel to, and positioned at or between, the lids 45a, 45b of the first and second portions 46, 47.As noted above, “above” and “below” are terms used for ease of reference, and since the cartridge 4 may be inverted from the position shown in FIG.", "61, the second portion 47 may be said to be “above” the plane and the first portion 46 may be said to be “below” the plane in the inverted orientation.", "The first and second portions 46, 47 may be connected together by a portion of the lids 45a, 45b, i.e., connector 45c, or another element.", "Thus, the first and second portions 46, 47 may be moved relative to each other from the position in FIG.", "61 to an orientation like that in FIG.", "62, e.g., for introduction into and interaction with a beverage making machine.", "The connector 45c or other portion of the lid 45 (or of the cartridge 4) may carry an identifier, such as a barcode, RFID tag or other device that can be read by a beverage making system and used to control system operation, e.g., to control a carbonation level, beverage volume, etc.", "Similar to the FIGS.", "58-60 embodiment, the first portion 46 may have the lid 45a pierced in one or more locations to admit activating fluid and/or release gas for carbonation or other purposes.", "Of course, the first portion 46 may operate to activate a gas source 41 and release gas in any suitable way as discussed herein, such as receiving activating fluid and/or releasing gas through a part of the first portion 46 opposite the lid 45a (e.g., the bottom of the first portion 46 as oriented in FIG.", "62).", "As with other embodiments, the first portion 46 may be made of any suitable material or combination of materials, such as a metal foil (e.g., aluminum) capsule.", "Similarly, the second portion 47 may be arranged in a variety of different ways, but in this embodiment is arranged so that a wall 47a of the second portion 47 can be moved so that beverage medium 42 is caused to exit the second portion 47.For example, the wall 47a may include a corrugated sheet of material (such as a sheet of aluminum foil that has a set of steps arranged as concentric annular rings) that can be pressed from the bottom (as shown by the arrows 200 in FIG.", "61) so that the wall 47a is collapsed toward the lid 45b (the lid 45b and upper rim of the wall 47a would be suitably supported by a beverage making machine chamber, for example).", "Movement of the wall 47a could cause a rise in pressure in the second portion 47, e.g., so that a burstable seal opens to release beverage medium 42 along the arrow 202.Of course, the wall 47a could be pierced to form an opening to allow beverage medium 42 to exit, rather than having a burstable or otherwise frangible seal open.", "In another illustrative embodiment shown in FIG.", "63, the second portion 47 may include an internal piercing element 203 arranged to pierce the wall 47a to form an outlet opening for beverage medium 42.For example, the piercing element 203 may be arranged so that with force applied to the lid 45a along the direction of the arrow 204, the piercing element 203 may be moved downwardly to pierce the wall 47a.", "In this action, the lid 45a may or may not be pierced.", "In one arrangement where the lid 45a is pierced, gas, precursor liquid or other fluid may be introduced into the second portion 47 to urge the beverage medium 42 out of the opening formed in the wall 47a.", "It should also be understood that an internal piercing element may be used with other embodiments described herein, such as in FIGS.", "58-60, and may be used in a first portion 46 of a cartridge 4.The wall 47a may be arranged so that when pushed in the direction of the arrows 200 in FIG.", "61, the radially outer portions of the wall 47a may collapse first, with radially inner portions of the wall 47a collapsing subsequently in a step-wise fashion toward a center of the wall 47a.", "This may help urge beverage medium 42 to move radially inwardly and out of the outlet.", "In other embodiments, the wall 47a may be arranged without corrugations, or otherwise without concern for how the wall 47a collapses.", "Instead, the wall 47a may be simply moved toward the lid 45b and the beverage medium 42 forced from the second portion 47 without control of flow in the second portion 47.Ifthe wall 47a is moved very closely adjacent to the lid 45b, most or all of the beverage medium 42 may be forced from the second portion 47.FIG.", "64 shows another illustrative embodiment in which a second portion 47 of the cartridge 4 is formed as an end-gusseted bag, e.g., formed from a sheet aluminum foil or other metal or plastic material.", "Such bags are well known in the food packaging art, and the second portion 47 in this embodiment is shown with the gusseted portion facing upwardly.", "An outlet nozzle 47b is arranged at a side of the bag (the bottom) opposite the gusset, and may include a burstable septum or other outlet arrangement that opens when the second portion 47 is squeezed or otherwise experiences an increase in pressure in the compartment where the beverage medium 42 is held.", "In one embodiment, the second portion 47 may be squeezed by air or other gas pressure that is introduced into a closed chamber in which the second portion 47 is held.", "The gas pressure may be provided by an air pump, compressed gas source, gas produced by the first portion 46, or other arrangement into a closed compartment that causes pressure to be exerted on the exterior of the second portion 47.Thus, the second portion 47 may have a wall, e.g., a part of the bag forming the second portion 47, that is moved to urge beverage medium to exit the second portion 47.The nozzle 47b may be located outside of the chamber in which pressure is introduced, e.g., so that beverage medium 42 forced from the nozzle 47b may enter a mixing chamber, a user's cup, etc.", "The nozzle 47b may include atomizing orifices or other features that help form small droplets or streams of beverage medium 42, e.g., as an aid to mixing.", "In accordance with an aspect of the invention, at least a part of the first portion 46 may be received into the gusset of the second portion 47.For example, the gusset may form a partial ellipsoid shaped cavity into which the first portion 46, which may have a complementary shape, can fit.", "In one embodiment, the first portion 46 may fit entirely within the gusset such that the first portion 46 can form a surface or base of the cartridge 4 such that the cartridge can stand upright on a flat surface with the first portion 46 supporting the cartridge.", "For example, the lid 45a of the first portion 46 may provide a flat surface at the top of the cartridge 4 when the first portion 46 is received into the gusset cavity of the second portion 47, allowing the cartridge 4 to be inverted and stood on a table top with the first portion 46 resting on the table.", "However, this is not necessary, and the first portion 46 may protrude from the gusset cavity of the second portion 47, e.g., with a domed top surface.", "With the first portion 46 at least partially received in the gusset cavity, a rim 462 of the first portion 46 may be crimped or otherwise attached to a rim 472 of the second portion 47 to engage the first and second portions 46, 47 together.", "As in other embodiments, the first portion 46 may include inlet and/or outlet regions 451, 452 arranged to accommodate piercing for inlet and/or outlet flows.", "As mentioned above, the second portion 47 may be squeezed or otherwise collapsed to release beverage medium 42.During this process, the first portion 46 may be subjected to the squeezing force, such as air pressure, opposed chamber walls moved toward each other with the second portion 47 located between the chamber walls, etc., or may be at least partially isolated from the squeezing force.", "For example, a rim 462 of the first portion 46 may be clamped in a cartridge receiver of a beverage making machine so that a sealed chamber located below the rim 462 can be formed around the second portion 47.This arrangement may help reduce or eliminate squeezing force on the first portion 46.FIG.", "65 shows another illustrative embodiment of a cartridge.", "In this embodiment, the cartridge 4 includes a cylindrical container with a first portion 46 located on one side (an upper region as shown) of the container, and a second portion 47 located on an opposite side (a lower region).", "The first and second portions 46, 47 may be separated by a wall, e.g., that establishes an air tight space in which beverage medium 42 is located.", "The first portion 46 may be piercable to admit activating liquid into, and/or allow gas to exit the first portion 46, or may be arranged in other ways as discussed above.", "However, in this embodiment, the second portion 47 is arranged to initially hold a gas under pressure in the air tight space with the beverage medium 42 so that when an outlet valve 47b is opened (e.g., by moving a part of the valve relative to the second portion 47), the pressurized gas expands and forces the beverage medium 42 to pass through the valve 47b and out of the second portion 47.Thus, a beverage making machine using the cartridge 4 would not be required to introduce gas, liquid or other fluid into the second portion 47 to expel the beverage medium 42.Instead, opening of the valve 47b, which could be done automatically by the machine or by a user, could cause the beverage medium 42 to be dispensed.", "In an alternate embodiment, the pressurized gas in the second portion 47 could be received from the first portion 46, e.g., a wall separating the first and second portions 46, 47 could be permeable, at least with the first portion 46 under suitable pressure, so that gas generated by the gas source 41 can flow into the second portion 47, thus pressurizing the second portion 47 for dispensing of the beverage medium 42.Alternately, pressurized gas could be introduced into the second portion 47 by a beverage forming machine, e.g., via a piercing needle, port or other mechanism.", "Example 1 The release properties of a carbon dioxide adsorbent were measured in the following way: 8×12 beads of sodium zeolite 13× (such as are commercially available from UOP MOLSIV Adsorbents) were obtained.", "The beads were placed in a ceramic dish and fired in a Vulcan D550 furnace manufactured by Ceramco.", "The temperature in the furnace containing the beads was raised to 550° C. at a rate of 3° C./min and was held at 550° C. for 5 hours for firing and preparation of the beads for charging with carbon dioxide.", "The beads were removed from the furnace and immediately transferred to a metal container equipped with a tightly fitted lid and entrance and exit ports permitting circulation of gas.", "With the beads sealed in the container, the container was flooded with carbon dioxide gas and pressurized to 15 psig.", "(Note, however, that experiments have been performed between 5-32 psig.)", "The chamber was held at the set pressure for 1 hour.", "During this hold period the chamber was bled every 15 min.", "At the end of this period a quantity of gas had adsorbed to the beads.", "A 30 g sample of charged 13× zeolite was measured, and a beaker filled with 250 ml of water at room temperature of 22° C. The beaker and water was placed on a balance and the balance zeroed.", "The 30 g of charged zeolite was then added to the beaker and the change in weight versus time was measured.", "It was shown that the change in weight became approximately steady after a period of 50 seconds, and that the beads lost about 4.2 g (14 wt %) of weight attributed to the release of carbon dioxide.", "Of course, some carbon dioxide may have been dissolved into the water.", "Time (sec) Weight (grams) 0 30 25 26.7 50 25.8 75 25.6 100 25.5 Example 2 Charged zeolite 13× was prepared as in Example 1.A 30 g sample of the charged zeolites was then placed in metal chamber with a water inlet port at the bottom and a gas outlet port at the top.", "The chamber that held the zeolites was 34×34 mm in cross section and had 2 metal filter discs with 64 1/16″ diameter holes to retain the zeolite material.", "Tap water was then flooded into the bottom of the chamber perpendicular to the cross-section at an average flow rate of 60 ml/min.", "Gas evolved through the top outlet port.", "The pressure of the gas in the chamber was measured with a pressure gauge and controlled using a needle valve attached to the exit port of the gas chamber.", "The needle valve was set to maintain the chamber at a pressure of 35 psig by manually adjusting the valve over the course of exposing charged zeolites in the chamber to water.", "Once the valve was set to an operating pressure, the system would perform repeatably with zeolite samples charged in the same manner.", "Example 3 Charged zeolite 13× was prepared as in Example 1.A 30 g sample of the charged zeolites was then placed in a semi rigid 50 ml polystyrene-polyethylene-EVOH laminate cup container and thermally sealed with a foil lid.", "The sealed zeolite cartridges were then placed into a sealed, metal cartridge chamber and pierced on the top and bottom.", "Tap water was introduced at the bottom of the cartridge with the flow controlled by a solenoid valve.", "The solenoid valve was actuated via a pressure switch connected to the top gas outlet of the cartridge chamber.", "During three different tests, the pressure switch was set to three different operating pressures of 5, 22, and 35 psig.", "The resulting gas at the set pressures was then introduced into the shellside of a hydrophobic membrane contactor (1×5.5 Minimodule from Liquicel, of Charlotte, N.C.).", "The other shellside port was plugged to prevent gas from escaping.", "Water from a reservoir containing 400 ml of water and approximately 50 g of ice was circulated from the reservoir, through the contactor, and back to the reservoir (e.g., like that shown in FIG.", "2) using an Ulka (Milan, Italy) type EAX 5 vibratory pump through the lumenside of the membrane contactor.", "The pressure of the reservoir and contactor was maintained at the same pressure as the gas was produced.", "The system produced gas and circulated the water for approximately 60 seconds before being stopped.", "The resulting carbonated water was then tested for carbonation levels using a CarboQC from Anton-Paar of Ashland, Va.", "The results for are shown in the table below: Average Carbonation Level System Pressure (psig) (Volumes C02 dissolved) 10 1.35 22 2.53 35 3.46 Thus, the gas was shown to evolve from the zeolites in the cartridges at a controllable rate (based on water delivery to the cartridge chamber) and then dissolved into water to produce a carbonated beverage.", "In addition, this illustrates the concept that by controlling system pressures one can control the level of carbonation of the finished beverage.", "It is expected that higher system pressures, e.g., of about 40-50 psi above ambient, would produce a 4 volume carbonated beverage (having a liquid volume of about 500 ml) in about 60 seconds or less.", "Having thus described several aspects of at least one embodiment of this invention, it is to be appreciated that various alterations, modifications, and improvements will readily occur to those skilled in the art.", "Such alterations, modifications, and improvements are intended to be part of this disclosure, and are intended to be within the spirit and scope of the invention.", "Accordingly, the foregoing description and drawings are by way of example only." ] ]
Patent_15872833
[ [ "SETTING APPARATUS, SETTING METHOD, AND STORAGE MEDIUM", "A setting apparatus which sets a detection region for a detection process of detecting a change of an image within a detection region corresponding to an object of detection inputs a first image in which the object of detection is present and a second image in which the object of detection is not present and determines the detection region from the first image and the second image such that the detection process may be performed on a detection region of a third image." ], [ "1.A setting apparatus which sets a detection region for a detection process of detecting a change of an image within the detection region corresponding to an object to be detected, the apparatus comprising: an interface configured to connect an image capture unit from which a first image in which the object to be detected is present and a second image in which the object to be detected is not present are input; and a processor, operatively coupled to a memory, and configured to display a guide in a captured image captured by the image capture unit for setting the detection region, based on the first image and the second image, wherein the guide is changeable by user operation.", "2.The setting apparatus according to claim 1, wherein the processor displays the guide as a polygon with a number of vertices not more than a predetermined number.", "3.The setting apparatus according to claim 1, wherein the processor is configured to allow a user to set the displayed guide as the detection region.", "4.The setting apparatus according to claim 1, wherein the detection process detects that the object to be detected has been removed.", "5.A method for determining a region in a setting apparatus which sets a detection region for detecting a change in the detection region of an image caused by a removal of an object which has existed in the detection region, the method comprising: inputting a first image in which the object does not exist and a second image in which the object exists, from an image capturing unit; and displaying a guide in a captured image captured by the image capture unit for setting the detection region based on the first image and the second image, wherein the guide is changeable by user operation.", "6.The method according to claim 5, wherein the guide is displayed as a polygon with a number of vertices not more than a predetermined number.", "7.The method according to claim 5, further comprising allowing a user to set the guide as the detection region.", "8.The method according to claim 5, wherein removal of the object to be detected is detected.", "9.A non-transitory storage medium storing a computer program for setting a detection region for detecting a change in the detection region of an image caused by a removal of an object which has existed in the detection region, the computer program comprising: inputting a first image does not exist and a second image in which the object exists, from an image capturing unit; and displaying a guide in a captured image captured by the image capture unit for setting the detection region based on the first image and the second image, wherein the guide is changeable by user operation.", "10.The non-transitory medium according to claim 9, wherein the guide polygon is displayed with a number of vertices not more than a predetermined number.", "11.The medium according to claim 9, further comprising allowing a user to set the guide as the detection region.", "12.The medium according to claim 9, wherein removal of the object to be detected is detected." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present invention may reduce the number of steps of a region-setting procedure by an operator.", "The present invention may further prevent deterioration of accuracy of detection.", "An aspect of the present invention may provide a setting apparatus which sets a detection region for a detection process of detecting a change of an image within a detection region corresponding to an object of detection, the apparatus including an input unit usable for inputting a first image in which the object of detection is present and a second image in which the object of detection is not present, and a determination unit configured to determine the detection region from the first image and the second image such that the detection process may be performed on a detection region of a third image.", "Another aspect of the present invention may further provide a method for determining a detection region in a setting apparatus which sets a detection region for a detection process of detecting a change of an image within a detection region corresponding to an object of detection, the method including inputting a first image in which the object of detection is present and a second image in which the object of detection is not present, and determining the detection region from the first image and the second image such that the detection process may be performed on a detection region of a third image.", "Further features of the present invention will become apparent from the following description of exemplary embodiments with reference to the attached drawings." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation, and claims the benefit, of U.S. patent application Ser.", "No.", "14/290,688, presently pending and filed on May 29, 2014, and claims the benefit of, and priority to, Japanese Patent Application No.", "2013-115668, filed May 31, 2013, which applications are hereby incorporated by reference herein in their entireties.", "BACKGROUND OF THE INVENTION Field of the Invention The present invention relates to a setting apparatus and method which set a detection region corresponding to a detection process of detecting a change of an image within the detection region for an object of detection.", "Description of the Related Art In recent years, for shop surveillance or building surveillance, for example, a captured image may be analyzed, and when a specific event is detected, an image in which the event is occurring may be stored or may be viewed and checked by a person in charge.", "Such specific events to be analyzed may include removal detection which is detection of removal of an object of surveillance, for example.", "U.S. Patent Application Publication No.", "2008/0018737, for example, discloses a function of detecting removal of an object of surveillance.", "However, in a case where an operator uses a pointing device, for example, to set a detection region corresponding to an object of detection within a video image, complicated operations are involved, imposing loads on the operator.", "Incorrect setting of such a detection region may result in lower accuracy of detection.", "SUMMARY OF THE INVENTION The present invention may reduce the number of steps of a region-setting procedure by an operator.", "The present invention may further prevent deterioration of accuracy of detection.", "An aspect of the present invention may provide a setting apparatus which sets a detection region for a detection process of detecting a change of an image within a detection region corresponding to an object of detection, the apparatus including an input unit usable for inputting a first image in which the object of detection is present and a second image in which the object of detection is not present, and a determination unit configured to determine the detection region from the first image and the second image such that the detection process may be performed on a detection region of a third image.", "Another aspect of the present invention may further provide a method for determining a detection region in a setting apparatus which sets a detection region for a detection process of detecting a change of an image within a detection region corresponding to an object of detection, the method including inputting a first image in which the object of detection is present and a second image in which the object of detection is not present, and determining the detection region from the first image and the second image such that the detection process may be performed on a detection region of a third image.", "Further features of the present invention will become apparent from the following description of exemplary embodiments with reference to the attached drawings.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a software configuration diagram according to an embodiment of the present invention.", "FIG.", "2 is a hardware configuration diagram according to an embodiment of the present invention.", "FIG.", "3 is a user interface according to an embodiment of the present invention.", "FIG.", "4 illustrates processing steps according to an embodiment of the present invention.", "FIG.", "5 is an explanatory diagram of process 1 according to an embodiment of the present invention.", "FIG.", "6 is an explanatory diagram of process 2 according to an embodiment of the present invention.", "FIG.", "7 is an explanatory diagram of process 3 according to an embodiment of the present invention.", "FIGS.", "8A to 8C are explanatory diagrams of process 4 according to an embodiment of the present invention.", "DESCRIPTION OF THE EMBODIMENTS FIG.", "1 is a software configuration diagram of an object detection system which provides a removal detection function according to a first embodiment of the present invention.", "Referring to FIG.", "1, the object detection system includes a setting apparatus 101, a network 102, a network camera 103, and a client terminal 120.On the setting apparatus 101, an object detection function setting tool runs which is configured to display a video image based on video data from the network camera 103 and provide a user interface for setting an object detection function for monitoring of removal of an object.", "The network 102 is a network that supports IP-based communication such as a LAN and the Internet.", "The network camera 103 has a video image capturing function and an object detection function and delivers a live image and detected object information regarding a detected object to the setting apparatus 101 and the client terminal 120 through the network 102.The setting apparatus 101 and client terminal 120 display a video image based on video data delivered from the network camera 103 and a detection result based on detected object information.", "When removal of an object is detected, the network camera 103 transmits detected object information to the setting apparatus 101.When the setting apparatus 101 receives the detected object information, the setting apparatus 101 displays a detection region frame and indicates that the object has been removed.", "In this case, the detection region frame is displayed in a different color from the color of the detection region frame while it is being set.", "The setting apparatus 101 is a display control apparatus configured to display a video image and detected object information.", "The network camera 103 has an image capturing unit 104, an object detecting unit 105, and a communication unit 106.It should be noted that the object detecting unit 105 may be provided in the setting apparatus 101 instead of in the network camera 103.The image capturing unit 104 acquires a live image by using an image capturing device.", "The image capturing unit 104 may be capable of acquiring a live image of 30 frames per second, for example.", "The image capturing unit 104 according to this embodiment encodes a live image acquired from an image capturing device to a JPEG image and converts it to digital video data that may be delivered over a network.", "Such a conversion function may be provided in the communication unit 106.The object detecting unit 105 analyzes the video data acquired by the image capturing unit 104 and detects whether an object within a detection region identified by the detection setting information set by the setting apparatus 101 has been removed or not.", "If a video image within the detection region has changed, the object detecting unit 105 detects that the object has been removed.", "The object detecting unit 105 of this embodiment detects removal of an object by analyzing a difference between consecutive video frames.", "Various methods may be applicable as the object removal detection algorithm, such as a method in which a difference between video data acquired by image capturing and a preset reference video image is analyzed.", "The communication unit 106 transmits video data acquired by the image capturing unit 104 and detected object information generated by the object detecting unit 105 to the client terminal 120 and setting apparatus 101 through the network 102.The communication unit 106 further receives detection setting information set by a user by using the setting apparatus 101 and sets it in the object detecting unit 105.The communication unit 110 receives video data and detected object information transmitted from the network camera 103.The communication unit 110 further transmits detection setting information set by a user by using the setting apparatus 101 to the network camera 103.The display control unit 111 displays a video image based on video data delivered from the network camera 103 on a display device such as a display.", "A detection frame setting unit 112 sets a detection region on a video image as detection setting information.", "The term “detection region” refers to a region where an object is to be detected within a video image.", "In other words, setting a detection region allows setting not all but a part of a video image (of an object to be monitored for removal) as an object of detection.", "From this, an improvement of accuracy of object detection and reduction of the processing load may be expected.", "The detection frame setting unit 112 causes the display control unit 111 to display a frame indicating a detection region on a video image.", "The display control unit 111 displays a video image from the network camera 103 in a video display region 302 (FIG.", "3).", "The display control unit 111 displays a detection region frame 303 within the video display region 302.A display example by the display control unit 111 will be described below with reference to FIG.", "3.A detection result display unit 115 causes the display control unit 111 to display the detection region frame 303 based on a detection result from the object detecting unit 105 in the network camera 103 as a result of the determination on whether the object has been removed or not.", "In this manner, the setting apparatus 101 sets a detection region corresponding to an object of detection within a video image for detection of a change within the detection region.", "The client terminal 120 receives video data and detected object information from the network camera 103 and displays the object detection result and the video image.", "In other words, the client terminal 120 has the communication unit 110, display control unit 111, and detection result display unit 115 among the components of the setting apparatus 101 and does not have the detection frame setting unit 112.FIG.", "2 illustrates hardware configurations of the setting apparatus 101 and the network camera 103.The client terminal 120 has the same hardware configuration as that of the setting apparatus 101.Referring to FIG.", "2, a CPU 201 is a control processing device configured to control the setting apparatus 101 overall.", "A secondary storage device 202 stores a program allowing the CPU 201 to control the setting apparatus 101.A RAM 203 is a memory configured to decompress a program read by the CPU 201 from the secondary storage device 202 and execute a process.", "The RAM 203 is also usable as a temporary memory functioning as a storage area for temporarily storing data to be processed.", "A network interface 204 is a circuit usable for communication through the network 102.The network interface 204 is used for reception of video data and detected object information from the network camera 103 and transmission of detection setting information.", "A display apparatus 205 is a display device such as a display configured to display a video image based on video data, for example.", "The setting apparatus 101 may be integrated with the display apparatus 205.An input device 206 may include a keyboard and a mouse, for example.", "The input device 206 may be a joystick, an audio input device or the like.", "The setting apparatus 101 may be configured as a general personal computer (PC).", "An object detection function setting tool configured to provide a user interface for setting an object detection function for an object of monitoring for removal may be implemented as software capable of running on a general PC.", "Having described that according to this embodiment the CPU 201 reads out a program from the secondary storage device 202 and executes processes, at least a part of processes of the components in FIG.", "1 may be performed by special hardware.", "Next, a hardware configuration of the network camera 103 will be described.", "Referring to FIG.", "2, a CPU 210 is a control unit configured to perform overall control of the network camera 103 overall.", "A ROM 211 stores a program configured to allow the CPU 210 to control the network camera 103.A secondary storage device equivalent to the secondary storage device 202 may be provided instead of the ROM 211.A RAM 212 is a memory usable for decompressing a program read from the ROM 211 and executing a process.", "The RAM 212 is also usable as a temporary memory functioning as a storage area for temporarily storing data to be processed.", "A network interface 213 is a circuit usable for communication through the network 102.The network interface 213 is used for transmission of video data and detected object information to the setting apparatus 101 and for reception of detection setting information.", "An image capturing apparatus 214 has an image capturing device such as a video camera configured to capture a live image as a moving image and still images.", "The network camera 103 and the image capturing apparatus 214 may be provided integrally or may be provided separately.", "Next, with reference to FIG.", "3, a user interface of the setting apparatus 101 will be described.", "The setting apparatus 101 executes an object detection function setting tool that is a computer program configured to display a video image from the network camera 103 on the display apparatus 205.A user interface illustrated in FIG.", "3 is displayed on a screen of the display apparatus 205 in FIG.", "2 under control of the display control unit 111 in FIG.", "1.The setting apparatus 101 and the display apparatus 205 may be provided integrally or separately.", "The setting apparatus 101 is a display control apparatus configured to display a video image on the display apparatus 205.Referring to FIG.", "3, a user interface display region 301 is a display region on a display of the display apparatus 205.The user interface display region 301 may be displayed fully or may be displayed as one window.", "A video display region 302 is a region for displaying a video image (live image) based on video data delivered from the network camera 103.A detection region frame 303 (frame indicated by a thin line in FIG.", "3) is a frame defining a subject region of an object detection process by the object detecting unit 105 in accordance with a setting by the detection frame setting unit 112.The detection region frame 303 is displayed by the display control unit 111 based on a setting by the detection frame setting unit 112 and the detection result display unit 115.When a detection region set button 304 is pressed or clicked, the detection frame setting unit 112 sets a detection region frame for an object of removal detection which is a subject of detection setting information, and the resulting frame is displayed as the detection region frame 303.The size and form may be changed by selecting and dragging a vertex or vertices or a border of the detection region frame 303 by using the input device 206 such as a mouse.", "When a detection region clear button 305 is pressed or clicked, the detection frame setting unit 112 cancels a setting for the detection region frame being a subject of the detection setting information and stores an image displayed on the video display region 302 as a background in the RAM 203.FIG.", "4 illustrates processing steps for explaining processing of creating detection setting information for the detection region frame 303 performed by the setting apparatus 101 according to this embodiment.", "In the setting apparatus 101, an object detection function setting tool operates which is configured to display a video image from the network camera 103.The processing in FIG.", "4 is performed in accordance with operations performed by an operator and the object detection function setting tool program recorded in the secondary storage device 202 and read to the RAM 203 and executed by the CPU 201.However, at least a part of the processing performed by the CPU 201 and CPU 210 of the processing in FIG.", "4 may be performed by special hardware.", "The setting apparatus 101 sets a detection region for an object of detection within a video image for detection of a change within the detection region in the following manner.", "(Process 1) Acquisition of Background A background acquisition process will be described with reference to FIG.", "5.In this example, an object such as a PC placed on the right side of a person shown in the video display region 302 in FIG.", "6 is an object of removal detection.", "The object of removal detection is saved to a part which is not shown in the video display region 302, and the detection region clear button 305 is then pressed (FIG.", "5).", "In response to pressing of the detection region clear button 305, the detection frame setting unit 112 acquires an image captured by the image capturing unit 104 and shown in the video display region 302 and stores it as a background image in the RAM 203.In this process, frames for a predetermined period of time (such as 10 seconds) or a predetermined number of frames (such as 300 frames) may be input, and a background image may be created based on the input frames.", "The input frames may be simply averaged or may be weight averaged with a predetermined weight.", "This background creation may be performed by the detection frame setting unit 112, or a background captured by the network camera 103 may be acquired by the detection frame setting unit 112.The currently set detection region is cleared if a detection region is set and the detection region clear button 305 is then pressed.", "(Process 2) Acquisition of Image Including Object of Detection A process of acquiring an image including an object of detection will be described with reference to FIG.", "6.An object of removal detection is placed at a predetermined position within the video display region 302, and the detection region set button 304 is then pressed.", "In response to pressing of the detection region set button 304, the detection frame setting unit 112 acquires an image captured by the image capturing unit 104 and shown in the video display region 302 and stores it in the RAM 203.Also in this process, frames for a predetermined period of time (such as 10 seconds) or a predetermined number of frames (such as 300 frames) may be input, and an image to be stored may be created based on the input frames.", "The input frames may be simply averaged or may be weight averaged with a predetermined weight.", "This background image creation may be performed by the detection frame setting unit 112, or a background image captured by the network camera 103 may be acquired by the detection frame setting unit 112.In this manner, a video image in which an object of detection is present and a video image in which the object of detection is not present are input through the communication unit 110 in processes 1 and 2.", "(Process 3) Extraction of Detection Region and Vertices A process of extracting a detection region and vertices will be described with reference to FIG.", "7.The detection frame setting unit 112 handles the image stored in process 1 as a background image and extracts a a region in which there is a difference between the background image and the image stored in process 2.In FIG.", "7, the images stored in process 1 and process 2 are divided into blocks, and a block having a difference is extracted as a difference region 310.The difference region 310 may be extracted in the form of pixels.", "In this manner, the detection frame setting unit 112 extracts a difference between a video image in which an object of detection is present and a video image in which it is not present.", "According to this embodiment, a polygon corresponding to a region determined as having a difference is created.", "Processes 1 to 3 may be executed in the network camera 103, and a result therefrom may be acquired by the detection frame setting unit 112.A detection region frame may be set by the network camera 103.When the difference region 310 is extracted, a line connecting vertices 311 surrounding the region is extracted.", "(Process 4) Thinning of Vertex of Detection Region Thinning of vertices of a detection region will be described with reference to FIG.", "8.In a case where the difference region 310 extracted in process 3 has a complicated form, problems may occur including an increased load on the system, insufficient display capabilities and part of the resulting displayed video image not appearing.", "In order to solve such problems, an inclusion ratio and a coverage are defined as will be described below, and threshold values are defined for the number of vertices, inclusion ratio, and coverage to reduce the number of vertices and loads on the system.", "Those threshold values may be held in a fixed manner in the secondary storage device 202 in the setting apparatus 101, or an interface may be provided which allows them to be changed externally to the setting apparatus 101.In this case, the inclusion ratio and the coverage may be expressed by Expression 1 and Expression 2: Inclusion Ratio=an area of a region surrounded by the detection region frame 303 within the difference region 310/an area of the difference region 310 (Expression 1) Coverage=an area of the difference region 310 within the detection region frame 303/an area of a region surrounded by the detection region frame 303 (Expression 2).", "The detection frame setting unit 112 calculates thin distances between the vertices 311.The calculation of a thin distance according to this embodiment uses Douglas-Peucker algorithm.", "The detection frame setting unit 112 calculates thin distances between the vertices 311 illustrated in FIG.", "8B, sorts the calculated thin distances between the vertices 311 in increasing order, and thins out a vertex having the shortest thin distance to reduce the number of vertices.", "The thin distance is the distance illustrated in FIG.", "8B.", "The detection frame setting unit 112 connects the vertices across the reduced vertex and extracts the detection region frame 303 based on the remaining vertices (FIG.", "8A).", "A thin distance of a vertex is a distance between a straight line connecting two vertices adjacent to the vertex and the vertex.", "Thus, the detection frame setting unit 112 reduces the number of vertices of a polygon calculated from a difference between a video image in which an object of detection is present and a video image in which it is not present to a predetermined number of vertices.", "In other words, the detection frame setting unit 112 deletes vertices in increasing order of distance between a straight line connecting two vertices adjacent to a vertex and the vertex such that the number of vertices may be made equal to or lower than a predetermined number of vertices.", "Thus, the detection frame setting unit 112 calculates a detection region (frame) which is a polygon having a number of vertices that is equal to or lower than the predetermined number of vertices.", "A method of reducing the number of vertices will be described below with reference to FIG.", "8C.", "The detection frame setting unit 112 continues thinning out the vertices 311 until the number of vertices 311 becomes lower than a threshold value for the number of vertices stored in the RAM 203 (S801).", "This thinning of vertices may be based on Minimum Distance method or Minimum Ratio method which is used for simplifying lines on a map.", "In this manner, the detection frame setting unit 112 calculates a detection region being a polygon having a predetermined number of vertices or less.", "The detection frame setting unit 112 acquires the inclusion ratio and coverage of the difference region 310 extracted in process 3 and the detection region frame 303 extracted in the step after the number of vertices 311 becomes lower than the threshold value for the number of vertices by using Expressions 1 and 2 above.", "If the inclusion ratio and coverage are lower than their corresponding predetermined threshold values stored in the RAM 203 (S805), the detection frame setting unit 112 outputs a message to the display apparatus 205 and stops the processing (S802).", "If the inclusion ratio and coverage are both equal to or higher than the threshold values (S806), the detection frame setting unit 112 again calculates thin distances between the remaining vertices 311 that have not been thinned out and extracts a detection region resulting from the thinning out of the vertex with the shortest thin distance (S803).", "The detection frame setting unit 112 calculates an inclusion ratio and coverage therefor.", "If the inclusion ratio and coverage are equal to or higher than the threshold values therefor (S806), the detection frame setting unit 112 defines the detection region resulting from the vertex thinning as the detection region frame 303 to reduce the number of vertices 311 in a range where the inclusion ratio and coverage therefor are not lower than the threshold values (S803).", "If one of the inclusion ratio and coverage is lower than the corresponding threshold value (S806), the detection frame setting unit 112 settles the detection region frame 303 created in step S803 or S801 as the final detection region frame 303 in process 4 (S804).", "The display control unit 111 displays the positions of the vertices that have not been thinned out and remain within the extracted detection region frame 303 and lines between the vertices on the display apparatus 205.If it is determined in step S801 that the number of vertices of a polygon corresponding to a region judged as having a difference in process 3 is equal to or lower than the threshold value and if it is determined in step S806 that the inclusion ratio and coverage are lower than the threshold values when the number of vertices is reduced, the polygon corresponding to a region judged as having a difference in process 3 is defined as a detection region frame.", "Even when the number of vertices 311 is not lower than the threshold value for the number of vertices, the inclusion ratio and coverage may be calculated, and the number of vertices may be reduced in a range where the inclusion ratio and coverage are higher than the threshold values therefor to define the detection region frame 303.In this manner, the detection frame setting unit 112 calculates a first polygon from a difference between a video image in which an object of detection is present and a video image in which it is not present and calculates a detection region (frame) which is a second polygon acquired by reducing the number of vertices of the first polygon in a range where the second polygon overlaps the first polygon at a predetermined ratio or higher.", "(Process 5) Adjustment of Detection Region Adjustment of a detection region will be described with reference to FIGS.", "8A to 8C and 3.The detection region frame 303 (FIG.", "8A) extracted in process 4 is displayed on the display apparatus 205 under control of the display control unit 111.The detection frame setting unit 112 changes the detection region frame 303 in response to an instruction given by changing a vertex or a line connecting vertices of the detection region frame 303 by using a pointing device such as a mouse.", "In a case where a vertex A is moved, lines AB and AC connecting two vertices B and C adjacent to the vertex A and the vertex A are changed to connect the moved vertex A and the vertices B and C. In a case where one point F of a line connecting two vertices D and E is caught and moved with a mouse, the point caught with the mouse is defined as a new vertex F between the vertices D and E, and the line connecting the vertices D and E is changed to a line connecting the vertices D and F and a line connecting the vertices F and E. However, if the number of vertices is higher than the threshold value in step S801 in FIG.", "8C when the vertex F is added, the vertex F is not added.", "If the number of vertices is higher than the threshold value when a vertex is added, a message notifying that the addition of the vertex is not allowed is displayed on the user interface display region 301.The detection frame setting unit 112 displays the detection region (frame) on a video image as illustrated in FIG.", "8A to change the detection region (frame) displayed on the video image.", "The detection frame setting unit 112 settles the detection region frame 303 if the detection region set button 304 is pressed (FIG.", "3).", "In a case where a user judges that adjustment is not necessary for the detection region frame calculated in process 4, the user does not perform the adjustment in process 5.The detection frame setting unit 112 transmits detection setting information to the object detecting unit 105 if the detection region frame 303 is settled.", "The object detecting unit 105 extracts an image of the detection region frame 303 set in the detection setting information from the image acquired in process 2 and compares the extracted image and the image captured by the image capturing unit 104.This allows detection of removal of an object of detection within the detection region frame 303.The object detecting unit 105 may be provided in the setting apparatus 101 instead of in the network camera 103.In this manner, the detection frame setting unit 112 calculates a detection region corresponding to an object of detection from a difference between a video image in which the object of detection extracted in process 3 is present and a video image in which it is not present.", "Use of the function of setting a removal detection range according to this embodiment may allow setting of a removal detection region imposing less load on the system and having predetermined inclusion ratio and coverage or higher, which may eliminate the necessity for complicated operations, as described above.", "While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments.", "The scope of the following claims is to be accorded the broadest interpretation so as to encompass all such modifications and equivalent structures and functions." ] ]
Patent_15872835
[ [ "PROCESSING OF AUDIO SIGNALS DURING HIGH FREQUENCY RECONSTRUCTION", "The application relates to HFR (High Frequency Reconstruction/Regeneration) of audio signals.", "In particular, the application relates to a method and system for performing HFR of audio signals having large variations in energy level across the low frequency range which is used to reconstruct the high frequencies of the audio signal.", "A system configured to generate a plurality of high frequency subband signals covering a high frequency interval from a plurality of low frequency subband signals is described.", "The system comprises means for receiving the plurality of low frequency subband signals; means for receiving a set of target energies, each target energy covering a different target interval within the high frequency interval and being indicative of the desired energy of one or more high frequency subband signals lying within the target interval; means for generating the plurality of high frequency subband signals from the plurality of low frequency subband signals and from a plurality of spectral gain coefficients associated with the plurality of low frequency subband signals, respectively; and means for adjusting the energy of the plurality of high frequency subband signals using the set of target energies." ], [ "1.A system configured to generate a plurality of energy-adjusted high frequency subband signals covering a high frequency interval from a plurality of low frequency subband signals, the system comprising one or more processors adapted to: receive the plurality of low frequency subband signals; receive a set of target energies, each target energy covering a different target interval within the high frequency interval and being indicative of the desired energy of one or more high frequency subband signals lying within the target interval; generate a plurality of high frequency subband signals from the plurality of low frequency subband signals and from a plurality of spectral gain coefficients associated with the plurality of low frequency subband signals, respectively, by applying the plurality of spectral gain coefficients to the plurality of low frequency subband signals; and adjust the energy of the plurality of high frequency subband signals using the set of target energies to generate the plurality of energy-adjusted high frequency subband signals, wherein adjusting the energy of the plurality of high frequency subband signals comprises determining, for each target interval, a common envelope adjustment value for each of the high frequency subband signals within the target interval.", "2.A method for generating a plurality of energy-adjusted high frequency subband signals covering a high frequency interval from a plurality of low frequency subband signals, the method comprising: receiving the plurality of low frequency subband signals; receiving a set of target energies, each target energy covering a different target interval within the high frequency interval and being indicative of the desired energy of one or more high frequency subband signals lying within the target interval; generating a plurality of high frequency subband signals from the plurality of low frequency subband signals and from a plurality of spectral gain coefficients associated with the plurality of low frequency subband signals, respectively, by applying the plurality of spectral gain coefficients to the plurality of low frequency subband signals; and adjusting the energy of the plurality of high frequency subband signals using the set of target energies to generate the plurality of energy-adjusted high frequency subband signals, wherein adjusting the energy of the plurality of high frequency subband signals comprises determining, for each target interval, a common envelope adjustment value for each of the high frequency subband signals within the target interval.", "3.A non-transitory computer readable storage medium comprising instructions, wherein the instructions, when executed by an audio signal processing device, cause the audio signal processing device to perform a method for generating a plurality of energy-adjusted high frequency subband signals covering a high frequency interval from a plurality of low frequency subband signals, the method comprising: receiving the plurality of low frequency subband signals; receiving a set of target energies, each target energy covering a different target interval within the high frequency interval and being indicative of the desired energy of one or more high frequency subband signals lying within the target interval; generating a plurality of high frequency subband signals from the plurality of low frequency subband signals and from a plurality of spectral gain coefficients associated with the plurality of low frequency subband signals, respectively, by applying the plurality of spectral gain coefficients to the plurality of low frequency subband signals; and adjusting the energy of the plurality of high frequency subband signals using the set of target energies to generate the plurality of energy-adjusted high frequency subband signals, wherein adjusting the energy of the plurality of high frequency subband signals comprises determining, for each target interval, a common envelope adjustment value for each of the high frequency subband signals within the target interval." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>HFR technologies, such as the Spectral Band Replication (SBR) technology, allow to significantly improve the coding efficiency of traditional perceptual audio codecs.", "In combination with MPEG-4 Advanced Audio Coding (AAC) HFR forms a very efficient audio codec, which is already in use within the XM Satellite Radio system and Digital Radio Mondiale, and also standardized within 3GPP, DVD Forum and others.", "The combination of AAC and SBR is called aacPlus.", "It is part of the MPEG-4 standard where it is referred to as the High Efficiency AAC Profile (HE-AAC).", "In general, HFR technology can be combined with any perceptual audio codec in a back and forward compatible way, thus offering the possibility to upgrade already established broadcasting systems like the MPEG Layer-2 used in the Eureka DAB system.", "HFR methods can also be combined with speech codecs to allow wide band speech at ultra low bit rates.", "The basic idea behind HFR is the observation that usually a strong correlation between the characteristics of the high frequency range of a signal and the characteristics of the low frequency range of the same signal is present.", "Thus, a good approximation for the representation of the original input high frequency range of a signal can be achieved by a signal transposition from the low frequency range to the high frequency range.", "This concept of transposition was established in WO 98/57436 which is incorporated by reference, as a method to recreate a high frequency band from a lower frequency band of an audio signal.", "A substantial saving in bit-rate can be obtained by using this concept in audio coding and/or speech coding.", "In the following, reference will be made to audio coding, but it should be noted that the described methods and systems are equally applicable to speech coding and in unified speech and audio coding (USAC).", "High Frequency Reconstruction can be performed in the time-domain or in the frequency domain, using a filterbank or transform of choice.", "The process usually involves several steps, where the two main operations are to firstly create a high frequency excitation signal, and to subsequently shape the high frequency excitation signal to approximate the spectral envelope of the original high frequency spectrum.", "The step of creating a high frequency excitation signal may e.g.", "be based on single sideband modulation (SSB) where a sinusoid with frequency ω is mapped to a sinusoid with frequency ω+Δ  where Δω is a fixed frequency shift.", "In other words, the high frequency signal may be generated from the low frequency signal by a “copy-up” operation of low frequency subbands to high frequency subbands.", "A further approach to creating a high frequency excitation signal may involve harmonic transposition of low frequency subbands.", "Harmonic transposition of order T is typically designed to map a sinusoid of frequency ω of the low frequency signal to a sinusoid with frequency Tω, with T>1, of the high frequency signal.", "The HFR technology may be used as part of source coding systems, where assorted control information to guide the HFR process is transmitted from an encoder to a decoder along with a representation of the narrow band/low frequency signal.", "For systems where no additional control signal can be transmitted, the process may be applied on the decoder side with the suitable control data estimated from the available information on the decoder side.", "The aforementioned envelope adjustment of the high frequency excitation signal aims at accomplishing a spectral shape that resembles the spectral shape of the original highband.", "In order to do so, the spectral shape of the high frequency signal has to be modified.", "Put differently, the adjustment to be applied to the highband is a function of the existing spectral envelope and the desired target spectral envelope.", "For systems that operate in the frequency domain, e.g.", "HFR systems implemented in a pseudo-QMF filterbank, prior art methods are suboptimal in this regard, since the creation of the highband signal, by means of combining several contributions from the source frequency range, introduces an artificial spectral envelope into the highband to be envelope adjusted.", "In other words, the highband or high frequency signal generated from the low frequency signal during the HFR process typically exhibits an artificial spectral envelope (typically comprising spectral discontinuities).", "This poses difficulties for the spectral envelope adjuster, since the adjuster not only has to have the ability to apply the desired spectral envelope with proper time and frequency resolution, but the adjustor also has to be able to undo the artificially introduced spectral characteristics by the HFR signal generator.", "This poses difficult design constraints on the envelope adjuster.", "As a result, these difficulties tend to lead to a perceived loss of high frequency energy, and audible discontinuities in the spectral shape in the highband signal, particularly for speech type signals.", "In other words, conventional HFR signal generators tend to introduce discontinuities and level variations into the highband signal for signals which have large variations in level over the lowband range, e.g.", "sibilants.", "When subsequently the envelope adjuster is exposed to this highband signal, the envelope adjuster cannot with reasonability and consistence separate the newly introduced discontinuity from any natural spectral characteristic of the low band signal.", "The present document outlines a solution to the aforementioned problem, which results in an increased perceived audio quality.", "In particular, the present document describes a solution to the problem of generating a highband signal from a lowband signal, wherein the spectral envelope of the highband signal is effectively adjusted to resemble the original spectral envelope in the highband without introducing undesirable artifacts." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present document proposes an additional correction step as part of the high frequency reconstruction signal generation.", "As a result of the additional correction step, the audio quality of the high frequency component or highband signal is improved.", "The additional correction step may be applied to all source coding systems that use high frequency reconstruction techniques, as well as to any single ended post processing method or system that aims at re-creating high frequencies of an audio signal.", "According to an aspect, a system configured to generate a plurality of high frequency subband signals covering a high frequency interval is described.", "The system may be configured to generate the plurality of high frequency subband signals from a plurality of low frequency subband signals.", "The plurality of low frequency subband signals may be subband signals of a lowband or narrowband audio signal, which may be determined using an analysis filterbank or transform.", "In particular, the plurality of low frequency subband signals may be determined from a lowband time-domain signal using an analysis QMF (quadrature mirror filter) filterbank or an FFT (Fast Fourier Transform).", "The plurality of generated high frequency subband signals may correspond to an approximation of the high frequency subband signals of an original audio signal from which the plurality of low frequency subband signals has been derived.", "In particular, the plurality of low frequency subband signals and the plurality of (re-)generated high frequency subband signals may correspond to the subbands of a QMF filterbank and/or an FFT transform.", "The system may comprise means for receiving the plurality of low frequency subband signals.", "As such, the system may be placed downstream of the analysis filterbank or transform which generates the plurality of low frequency subband signals from a lowband signal.", "The lowband signal may be an audio signal which has been decoded in a core decoder from a received bitstream.", "The bitstream may be stored on a storage medium, e.g.", "a compact disc or a DVD, or the bitstream may be received at the decoder over a transmission medium, e.g.", "an optical or radio transmission medium.", "The system may comprise means for receiving a set of target energies, which may also be referred to as scalefactor energies.", "Each target energy may cover a different target interval, which may also be referred to as a scalefactor band, within the high frequency interval.", "Typically, the set of target intervals which corresponds to the set of target energies covers the complete high frequency interval.", "A target energy of the set of target energies is usually indicative of the desired energy of one or more high frequency subband signals lying within the corresponding target interval.", "In particular, the target energy may correspond to the average desired energy of the one or more high frequency subband signals which lie within the corresponding target interval.", "The target energy of a target interval is typically derived from the energy of the highband signal of the original audio signal within the target interval.", "In other words, the set of target energies typically describes the spectral envelope of the highband portion of the original audio signal.", "The system may comprise means for generating the plurality of high frequency subband signals from the plurality of low frequency subband signals.", "For this purpose, the means for generating the plurality of high frequency subband signals may be configured to perform a copy-up transposition of the plurality of low frequency subband signals and/or to perform a harmonic transposition of the plurality of low frequency subband signals.", "Furthermore, the means for generating the plurality of high frequency subband signals may take into account a plurality of spectral gain coefficients during the generation process of the plurality of high frequency subband signals.", "The plurality of spectral gain coefficients may be associated with the plurality of low frequency subband signals, respectively.", "In other words, each low frequency subband signal of the plurality of low frequency subband signals may have a corresponding spectral gain coefficient from the plurality of spectral gain coefficients.", "A spectral gain coefficient from the plurality of spectral gain coefficients may be applied to the corresponding low frequency subband signal.", "The plurality of spectral gain coefficients may be associated with the energy of the respective plurality of low frequency subband signals.", "In particular, each spectral gain coefficient may be associated with the energy of its corresponding low frequency subband signal.", "In an embodiment, a spectral gain coefficient is determined based on the energy of the corresponding low frequency subband signal.", "For this purpose, a frequency dependent curve may be determined based on the plurality of energy values of the plurality of low frequency subband signals.", "In this case, a method for determining the plurality of gain coefficients may rely on the frequency dependent curve which is determined from a (e.g.", "logarithmic) representation of the energies of the plurality of low frequency subband signals.", "In other words, the plurality of spectral gain coefficients may be derived from a frequency dependent curve fitted to the energy of the plurality of low frequency subband signals.", "In particular, the frequency dependent curve may be a polynomial of a pre-determined order/degree.", "Alternatively, or in addition, the frequency dependent curve may comprise different curve segments, wherein the different curve segments are fitted to the energy of the plurality of low frequency subband signals at different frequency intervals.", "The different curve segments may be different polynomials of a pre-determined order.", "In an embodiment, the different curve segments are polynomials of order zero, such that the curve segments represent the mean energy values of the energy of the plurality of low frequency subband signals within the corresponding frequency interval.", "In a further embodiment, the frequency dependent curve is fitted to the energy of the plurality of low frequency subband signals by performing a moving average filtering operation along the different frequency intervals.", "In an embodiment, a gain coefficient of the plurality of gain coefficients is derived from the difference of the mean energy of the plurality of low frequency subband signals and of a corresponding value of the frequency dependent curve.", "The corresponding value of the frequency dependent curve may be a value of the curve at a frequency lying within the frequency range of the low frequency subband signal to which the gain coefficient corresponds.", "Typically, the energy of the plurality of low frequency subband signals is determined on a certain time-grid, e.g.", "on a frame by frame basis, i.e.", "the energy of a low frequency subband signal within a time interval defined by the time-grid corresponds to the average energy of the samples of the low frequency subband signal within the time interval, e.g.", "within a frame.", "As such, a different plurality of spectral gain coefficients may be determined on the chosen time-grid, e.g.", "a different plurality of spectral gain coefficients may be determined for each frame of the audio signal.", "In an embodiment, the plurality of spectral gain coefficients may be determined on a sample by sample basis, e.g.", "by determining the energy of the plurality of low frequency subbands using a floating window across the samples of each low frequency subband signal.", "It should be noted that the system may comprise means for determining the plurality of spectral gain coefficients from the plurality of low frequency subband signals.", "These means may be configured to perform the above mentioned methods for determining the plurality of spectral gain coefficients.", "The means for generating the plurality of high frequency subband signals may be configured to amplify the plurality of low frequency subband signals using the respective plurality of spectral gain coefficients.", "Even though reference is made to “amplifying” or “amplification” in the following, the “amplification” operation may be replaced by other operations, such as a “multiplication” operation, a “rescaling” operation or an “adjustment” operation.", "The amplification may be done by multiplying a sample of a low frequency subband signal with its corresponding spectral gain coefficient.", "In particular, the means for generating the plurality of high frequency subband signals may be configured to determine a sample of a high frequency subband signal at a given time instant from samples of a low frequency subband signal at the given time instant and at at least one preceding time instant.", "Furthermore, the samples of the low frequency subband signal may be amplified by the respective spectral gain coefficient of the plurality of spectral gain coefficients.", "In an embodiment, the means for generating the plurality of high frequency subband signals are configured to generate the plurality of high frequency subband signals from the plurality of low frequency subband signals in accordance to the “copy-up” algorithm specified in MPEG-4 SBR.", "The plurality of low frequency subband signals used in this “copy-up” algorithm may have been amplified using the plurality of spectral gain coefficients, wherein the “amplification” operation may have been performed as outlined above.", "The system may comprise means for adjusting the energy of the plurality of high frequency subband signals using the set of target energies.", "This operation is typically referred to as spectral envelope adjustment.", "The spectral envelope adjustment may be performed by adjusting the energy of the plurality of high frequency subband signals such that the average energy of the plurality of high frequency subband signals lying within a target interval corresponds to the corresponding target energy.", "This may be achieved by determining an envelope adjustment value from the energy values of the plurality of high frequency subband signals lying within a target interval and the corresponding target energy.", "In particular, the envelope adjustment value may be determined from a ratio of the target energy and the energy values of the plurality of high frequency subband signals lying within a corresponding target interval.", "This envelope adjustment value may be used for adjusting the energy of the plurality of high frequency subband signals.", "In an embodiment, the means for adjusting the energy comprise means for limiting the adjustment of the energy of the high frequency subband signals lying within a limiter interval.", "Typically, the limiter interval covers more than one target interval.", "The means for limiting are usually used for avoiding an undesirable amplification of noise within certain high frequency subband signals.", "For example, the means for limiting may be configured to determine a mean envelope adjustment value of the envelope adjustment values corresponding to the target intervals covered by or lying within the limiter interval.", "Furthermore, the means for limiting may be configured to limit the adjustment of the energy of the high frequency subband signals lying within the limiter interval to a value which is proportional to the mean envelope adjustment value.", "Alternatively, or in addition, the means for adjusting the energy of the plurality of high frequency subband signals may comprise means for ensuring that the adjusted high frequency subband signals lying within the particular target interval have the same energy.", "The latter means are often referred to as “interpolation” means.", "In other words, the “interpolation” means ensure that the energy of each of the high frequency subband signals lying within the particular target interval corresponds to the target energy.", "The “interpolation” means may be implemented by adjusting each high frequency subband signal within the particular target interval separately such that the energy of the adjusted high frequency subband signal corresponds to the target energy associated with the particular target interval.", "This may be achieved by determining a different envelope adjustment value for each high frequency subband signal within the particular target interval.", "A different envelope adjustment value may be determined based on the energy of the particular high frequency subband signal and the target energy corresponding to the particular target interval.", "In an embodiment, an envelope adjustment value for a particular high frequency subband signal is determined based on the ratio of the target energy and the energy of the particular high frequency subband signal.", "The system may further comprise means for receiving control data.", "The control data may be indicative of whether to apply the plurality of spectral gain coefficients to generate the plurality of high frequency subband signals.", "In other words, the control data may be indicative of whether the additional gain adjustment of the low frequency subband signals is to be performed or not.", "Alternatively or in addition, the control data may be indicative of a method which is to be used for determining the plurality of spectral gain coefficients.", "By way of example, the control data may be indicative of the pre-determined order of the polynomial which is to be used to determine the frequency dependent curve fitted to the energies of the plurality of low frequency subband signals.", "The control data is typically received from a corresponding encoder which analyzes the original audio signal and informs the corresponding decoder or HFR system on how to decode the bitstream.", "According to another aspect, an audio decoder configured to decode a bitstream comprising a low frequency audio signal and comprising a set of target energies describing the spectral envelope of a high frequency audio signal is described.", "In other words, an audio decoder configured to decode a bitstream representative of a low frequency audio signal and representative of a set of target energies describing the spectral envelope of a high frequency audio signal is described.", "The audio decoder may comprise a core decoder and/or transform unit configured to determine a plurality of low frequency subband signals associated with the low frequency audio signal from the bitstream.", "Alternatively or in addition, the audio decoder may comprise a high frequency generation unit according to the system outlined in the present document, wherein the system may be configured to determine a plurality of high frequency subband signals from the plurality of low frequency subband signals and the set of target energies.", "Alternatively or in addition, the decoder may comprise a merging and/or inverse transform unit configured to generate an audio signal from the plurality of low frequency subband signals and the plurality of high frequency subband signals.", "The merging and inverse transform unit may comprise a synthesis filterbank or transform, e.g.", "an inverse QMF filterbank or an inverse FFT.", "According to a further aspect, an encoder configured to generate control data from an audio signal is described.", "The audio encoder may comprise means to analyse the spectral shape of the audio signal and to determine a degree of spectral envelope discontinuities introduced when re-generating a high frequency component of the audio signal from a low frequency component of the audio signal.", "As such, the encoder may comprise certain elements of a corresponding decoder.", "In particular, the encoder may comprise a HFR system as outlined in the present document.", "This would enable the encoder to determine the degree of discontinuities in the spectral envelope which could be introduced to the high frequency component of the audio signal on the decoder side.", "Alternatively or in addition, the encoder may comprise means to generate control data for controlling the re-generation of the high frequency component based on the degree of discontinuities.", "In particular, the control data may correspond to the control data received by the corresponding decoder or the HFR system.", "The control data may be indicative of whether to use the plurality of spectral gain coefficients during the HFR process and/or which pre-determined polynomial order to use in order to determine the plurality of spectral gain coefficients.", "In order to determine this information a ratio of the selected parts of the low frequency interval, i.e.", "the frequency range covered by the plurality of low frequency subband signals, could be determined.", "This ratio information can be determined by e.g.", "studying the lowest frequencies of the lowband, and the highest frequencies of the lowband to assess the spectral variation of the lowband signal that in the decoder subsequently will be used for high frequency reconstruction.", "A high ratio could indicate an increased degree of discontinuity.", "The control data could also be determined using signal type detectors.", "By way of example, the detection of speech signals could indicate an increased degree of discontinuity.", "On the other hand, the detection of prominent sinusoids in the original audio signal could lead to control data indicating that the plurality of spectral gain coefficients should not be used during the HFR process.", "According to another aspect, a method for generating a plurality of high frequency subband signals covering a high frequency interval from a plurality of low frequency subband signals is described.", "The method may comprise the steps of receiving the plurality of low frequency subband signals and/or of receiving a set of target energies.", "Each target energy may cover a different target interval within the high frequency interval.", "Furthermore, each target energy may be indicative of the desired energy of one or more high frequency subband signals lying within the target interval.", "The method may comprise the step of generating the plurality of high frequency subband signals from the plurality of low frequency subband signals and from a plurality of spectral gain coefficients associated with the plurality of low frequency subband signals, respectively.", "Alternatively or in addition, the method may comprise the step of adjusting the energy of the plurality of high frequency subband signals using the set of target energies.", "The step of adjusting the energy may comprise the step of limiting the adjustment of the energy of the high frequency subband signals lying within a limiter interval.", "Typically, the limiter interval covers more than one target interval.", "According to a further aspect, a method for decoding a bitstream representative of or comprising a low frequency audio signal and a set of target energies describing the spectral envelope of a corresponding high frequency audio signal is described.", "Typically, the low frequency and high frequency audio signals correspond to a low frequency and high frequency component of the same original audio signal.", "The method may comprise the step of determining a plurality of low frequency subband signals associated with the low frequency audio signal from the bitstream.", "Alternatively or in addition, the method may comprise the step of determining a plurality of high frequency subband signals from the plurality of low frequency subband signals and the set of target energies.", "This step is typically performed in accordance with the HFR methods outlined in the present document.", "Subsequently, the method may comprise the step of generating an audio signal from the plurality of low frequency subband signals and the plurality of high frequency subband signals.", "According to another aspect, a method for generating control data from an audio signal is described.", "The method may comprise the step of analysing the spectral shape of the audio signal in order to determine a degree of discontinuities introduced when re-generating a high frequency component of the audio signal from a low frequency component of the audio signal.", "Furthermore, the method may comprise the step of generating control data for controlling the re-generation of the high frequency component based on the degree of discontinuities.", "According to a further aspect, a software program is described.", "The software program may be adapted for execution on a processor and for performing the method steps outlined in the present document when carried out on a computing device.", "According to another aspect, a storage medium is described.", "The storage medium may comprise a software program adapted for execution on a processor and for performing the method steps outlined in the present document when carried out on a computing device.", "According to a further aspect, a computer program product is described.", "The computer program may comprise executable instructions for performing the method steps outlined in the present document when executed on a computer.", "It should be noted that the methods and systems including their preferred embodiments as outlined in the present patent application may be used stand-alone or in combination with the other methods and systems disclosed in this document.", "Furthermore, all aspects of the methods and systems outlined in the present patent application may be arbitrarily combined.", "In particular, the features of the claims may be combined with one another in an arbitrary manner." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "15/429,545, filed Feb. 10, 2017, which is a continuation of U.S. patent application Ser.", "No.", "14/799,800, filed on Jul.", "15, 2015, now U.S. Pat.", "No.", "9,640,184, which is a continuation of U.S. patent application Ser.", "No.", "13/582,967, filed on Sep. 5, 2012, now U.S. Pat.", "No.", "9,117,459, which is the national stage entry for PCT Application Serial No.", "PCT/EP2011/062068, filed on Jul.", "14, 2011, which claims the benefit of priority to U.S.", "Provisional patent application Ser.", "No.", "61/386,725, filed on Sep. 27, 2010 and U.S.", "Provisional patent application Ser.", "No.", "61/365,518, filed on Jul.", "19, 2010, each of which is hereby incorporated by reference in its entirety.", "TECHNICAL FIELD The application relates to HFR (High Frequency Reconstruction/Regeneration) of audio signals.", "In particular, the application relates to a method and system for performing HFR of audio signals having large variations in energy level across the low frequency range which is used to reconstruct the high frequencies of the audio signal.", "BACKGROUND OF THE INVENTION HFR technologies, such as the Spectral Band Replication (SBR) technology, allow to significantly improve the coding efficiency of traditional perceptual audio codecs.", "In combination with MPEG-4 Advanced Audio Coding (AAC) HFR forms a very efficient audio codec, which is already in use within the XM Satellite Radio system and Digital Radio Mondiale, and also standardized within 3GPP, DVD Forum and others.", "The combination of AAC and SBR is called aacPlus.", "It is part of the MPEG-4 standard where it is referred to as the High Efficiency AAC Profile (HE-AAC).", "In general, HFR technology can be combined with any perceptual audio codec in a back and forward compatible way, thus offering the possibility to upgrade already established broadcasting systems like the MPEG Layer-2 used in the Eureka DAB system.", "HFR methods can also be combined with speech codecs to allow wide band speech at ultra low bit rates.", "The basic idea behind HFR is the observation that usually a strong correlation between the characteristics of the high frequency range of a signal and the characteristics of the low frequency range of the same signal is present.", "Thus, a good approximation for the representation of the original input high frequency range of a signal can be achieved by a signal transposition from the low frequency range to the high frequency range.", "This concept of transposition was established in WO 98/57436 which is incorporated by reference, as a method to recreate a high frequency band from a lower frequency band of an audio signal.", "A substantial saving in bit-rate can be obtained by using this concept in audio coding and/or speech coding.", "In the following, reference will be made to audio coding, but it should be noted that the described methods and systems are equally applicable to speech coding and in unified speech and audio coding (USAC).", "High Frequency Reconstruction can be performed in the time-domain or in the frequency domain, using a filterbank or transform of choice.", "The process usually involves several steps, where the two main operations are to firstly create a high frequency excitation signal, and to subsequently shape the high frequency excitation signal to approximate the spectral envelope of the original high frequency spectrum.", "The step of creating a high frequency excitation signal may e.g.", "be based on single sideband modulation (SSB) where a sinusoid with frequency ω is mapped to a sinusoid with frequency ω+Δ where Δω is a fixed frequency shift.", "In other words, the high frequency signal may be generated from the low frequency signal by a “copy-up” operation of low frequency subbands to high frequency subbands.", "A further approach to creating a high frequency excitation signal may involve harmonic transposition of low frequency subbands.", "Harmonic transposition of order T is typically designed to map a sinusoid of frequency ω of the low frequency signal to a sinusoid with frequency Tω, with T>1, of the high frequency signal.", "The HFR technology may be used as part of source coding systems, where assorted control information to guide the HFR process is transmitted from an encoder to a decoder along with a representation of the narrow band/low frequency signal.", "For systems where no additional control signal can be transmitted, the process may be applied on the decoder side with the suitable control data estimated from the available information on the decoder side.", "The aforementioned envelope adjustment of the high frequency excitation signal aims at accomplishing a spectral shape that resembles the spectral shape of the original highband.", "In order to do so, the spectral shape of the high frequency signal has to be modified.", "Put differently, the adjustment to be applied to the highband is a function of the existing spectral envelope and the desired target spectral envelope.", "For systems that operate in the frequency domain, e.g.", "HFR systems implemented in a pseudo-QMF filterbank, prior art methods are suboptimal in this regard, since the creation of the highband signal, by means of combining several contributions from the source frequency range, introduces an artificial spectral envelope into the highband to be envelope adjusted.", "In other words, the highband or high frequency signal generated from the low frequency signal during the HFR process typically exhibits an artificial spectral envelope (typically comprising spectral discontinuities).", "This poses difficulties for the spectral envelope adjuster, since the adjuster not only has to have the ability to apply the desired spectral envelope with proper time and frequency resolution, but the adjustor also has to be able to undo the artificially introduced spectral characteristics by the HFR signal generator.", "This poses difficult design constraints on the envelope adjuster.", "As a result, these difficulties tend to lead to a perceived loss of high frequency energy, and audible discontinuities in the spectral shape in the highband signal, particularly for speech type signals.", "In other words, conventional HFR signal generators tend to introduce discontinuities and level variations into the highband signal for signals which have large variations in level over the lowband range, e.g.", "sibilants.", "When subsequently the envelope adjuster is exposed to this highband signal, the envelope adjuster cannot with reasonability and consistence separate the newly introduced discontinuity from any natural spectral characteristic of the low band signal.", "The present document outlines a solution to the aforementioned problem, which results in an increased perceived audio quality.", "In particular, the present document describes a solution to the problem of generating a highband signal from a lowband signal, wherein the spectral envelope of the highband signal is effectively adjusted to resemble the original spectral envelope in the highband without introducing undesirable artifacts.", "SUMMARY OF THE INVENTION The present document proposes an additional correction step as part of the high frequency reconstruction signal generation.", "As a result of the additional correction step, the audio quality of the high frequency component or highband signal is improved.", "The additional correction step may be applied to all source coding systems that use high frequency reconstruction techniques, as well as to any single ended post processing method or system that aims at re-creating high frequencies of an audio signal.", "According to an aspect, a system configured to generate a plurality of high frequency subband signals covering a high frequency interval is described.", "The system may be configured to generate the plurality of high frequency subband signals from a plurality of low frequency subband signals.", "The plurality of low frequency subband signals may be subband signals of a lowband or narrowband audio signal, which may be determined using an analysis filterbank or transform.", "In particular, the plurality of low frequency subband signals may be determined from a lowband time-domain signal using an analysis QMF (quadrature mirror filter) filterbank or an FFT (Fast Fourier Transform).", "The plurality of generated high frequency subband signals may correspond to an approximation of the high frequency subband signals of an original audio signal from which the plurality of low frequency subband signals has been derived.", "In particular, the plurality of low frequency subband signals and the plurality of (re-)generated high frequency subband signals may correspond to the subbands of a QMF filterbank and/or an FFT transform.", "The system may comprise means for receiving the plurality of low frequency subband signals.", "As such, the system may be placed downstream of the analysis filterbank or transform which generates the plurality of low frequency subband signals from a lowband signal.", "The lowband signal may be an audio signal which has been decoded in a core decoder from a received bitstream.", "The bitstream may be stored on a storage medium, e.g.", "a compact disc or a DVD, or the bitstream may be received at the decoder over a transmission medium, e.g.", "an optical or radio transmission medium.", "The system may comprise means for receiving a set of target energies, which may also be referred to as scalefactor energies.", "Each target energy may cover a different target interval, which may also be referred to as a scalefactor band, within the high frequency interval.", "Typically, the set of target intervals which corresponds to the set of target energies covers the complete high frequency interval.", "A target energy of the set of target energies is usually indicative of the desired energy of one or more high frequency subband signals lying within the corresponding target interval.", "In particular, the target energy may correspond to the average desired energy of the one or more high frequency subband signals which lie within the corresponding target interval.", "The target energy of a target interval is typically derived from the energy of the highband signal of the original audio signal within the target interval.", "In other words, the set of target energies typically describes the spectral envelope of the highband portion of the original audio signal.", "The system may comprise means for generating the plurality of high frequency subband signals from the plurality of low frequency subband signals.", "For this purpose, the means for generating the plurality of high frequency subband signals may be configured to perform a copy-up transposition of the plurality of low frequency subband signals and/or to perform a harmonic transposition of the plurality of low frequency subband signals.", "Furthermore, the means for generating the plurality of high frequency subband signals may take into account a plurality of spectral gain coefficients during the generation process of the plurality of high frequency subband signals.", "The plurality of spectral gain coefficients may be associated with the plurality of low frequency subband signals, respectively.", "In other words, each low frequency subband signal of the plurality of low frequency subband signals may have a corresponding spectral gain coefficient from the plurality of spectral gain coefficients.", "A spectral gain coefficient from the plurality of spectral gain coefficients may be applied to the corresponding low frequency subband signal.", "The plurality of spectral gain coefficients may be associated with the energy of the respective plurality of low frequency subband signals.", "In particular, each spectral gain coefficient may be associated with the energy of its corresponding low frequency subband signal.", "In an embodiment, a spectral gain coefficient is determined based on the energy of the corresponding low frequency subband signal.", "For this purpose, a frequency dependent curve may be determined based on the plurality of energy values of the plurality of low frequency subband signals.", "In this case, a method for determining the plurality of gain coefficients may rely on the frequency dependent curve which is determined from a (e.g.", "logarithmic) representation of the energies of the plurality of low frequency subband signals.", "In other words, the plurality of spectral gain coefficients may be derived from a frequency dependent curve fitted to the energy of the plurality of low frequency subband signals.", "In particular, the frequency dependent curve may be a polynomial of a pre-determined order/degree.", "Alternatively, or in addition, the frequency dependent curve may comprise different curve segments, wherein the different curve segments are fitted to the energy of the plurality of low frequency subband signals at different frequency intervals.", "The different curve segments may be different polynomials of a pre-determined order.", "In an embodiment, the different curve segments are polynomials of order zero, such that the curve segments represent the mean energy values of the energy of the plurality of low frequency subband signals within the corresponding frequency interval.", "In a further embodiment, the frequency dependent curve is fitted to the energy of the plurality of low frequency subband signals by performing a moving average filtering operation along the different frequency intervals.", "In an embodiment, a gain coefficient of the plurality of gain coefficients is derived from the difference of the mean energy of the plurality of low frequency subband signals and of a corresponding value of the frequency dependent curve.", "The corresponding value of the frequency dependent curve may be a value of the curve at a frequency lying within the frequency range of the low frequency subband signal to which the gain coefficient corresponds.", "Typically, the energy of the plurality of low frequency subband signals is determined on a certain time-grid, e.g.", "on a frame by frame basis, i.e.", "the energy of a low frequency subband signal within a time interval defined by the time-grid corresponds to the average energy of the samples of the low frequency subband signal within the time interval, e.g.", "within a frame.", "As such, a different plurality of spectral gain coefficients may be determined on the chosen time-grid, e.g.", "a different plurality of spectral gain coefficients may be determined for each frame of the audio signal.", "In an embodiment, the plurality of spectral gain coefficients may be determined on a sample by sample basis, e.g.", "by determining the energy of the plurality of low frequency subbands using a floating window across the samples of each low frequency subband signal.", "It should be noted that the system may comprise means for determining the plurality of spectral gain coefficients from the plurality of low frequency subband signals.", "These means may be configured to perform the above mentioned methods for determining the plurality of spectral gain coefficients.", "The means for generating the plurality of high frequency subband signals may be configured to amplify the plurality of low frequency subband signals using the respective plurality of spectral gain coefficients.", "Even though reference is made to “amplifying” or “amplification” in the following, the “amplification” operation may be replaced by other operations, such as a “multiplication” operation, a “rescaling” operation or an “adjustment” operation.", "The amplification may be done by multiplying a sample of a low frequency subband signal with its corresponding spectral gain coefficient.", "In particular, the means for generating the plurality of high frequency subband signals may be configured to determine a sample of a high frequency subband signal at a given time instant from samples of a low frequency subband signal at the given time instant and at at least one preceding time instant.", "Furthermore, the samples of the low frequency subband signal may be amplified by the respective spectral gain coefficient of the plurality of spectral gain coefficients.", "In an embodiment, the means for generating the plurality of high frequency subband signals are configured to generate the plurality of high frequency subband signals from the plurality of low frequency subband signals in accordance to the “copy-up” algorithm specified in MPEG-4 SBR.", "The plurality of low frequency subband signals used in this “copy-up” algorithm may have been amplified using the plurality of spectral gain coefficients, wherein the “amplification” operation may have been performed as outlined above.", "The system may comprise means for adjusting the energy of the plurality of high frequency subband signals using the set of target energies.", "This operation is typically referred to as spectral envelope adjustment.", "The spectral envelope adjustment may be performed by adjusting the energy of the plurality of high frequency subband signals such that the average energy of the plurality of high frequency subband signals lying within a target interval corresponds to the corresponding target energy.", "This may be achieved by determining an envelope adjustment value from the energy values of the plurality of high frequency subband signals lying within a target interval and the corresponding target energy.", "In particular, the envelope adjustment value may be determined from a ratio of the target energy and the energy values of the plurality of high frequency subband signals lying within a corresponding target interval.", "This envelope adjustment value may be used for adjusting the energy of the plurality of high frequency subband signals.", "In an embodiment, the means for adjusting the energy comprise means for limiting the adjustment of the energy of the high frequency subband signals lying within a limiter interval.", "Typically, the limiter interval covers more than one target interval.", "The means for limiting are usually used for avoiding an undesirable amplification of noise within certain high frequency subband signals.", "For example, the means for limiting may be configured to determine a mean envelope adjustment value of the envelope adjustment values corresponding to the target intervals covered by or lying within the limiter interval.", "Furthermore, the means for limiting may be configured to limit the adjustment of the energy of the high frequency subband signals lying within the limiter interval to a value which is proportional to the mean envelope adjustment value.", "Alternatively, or in addition, the means for adjusting the energy of the plurality of high frequency subband signals may comprise means for ensuring that the adjusted high frequency subband signals lying within the particular target interval have the same energy.", "The latter means are often referred to as “interpolation” means.", "In other words, the “interpolation” means ensure that the energy of each of the high frequency subband signals lying within the particular target interval corresponds to the target energy.", "The “interpolation” means may be implemented by adjusting each high frequency subband signal within the particular target interval separately such that the energy of the adjusted high frequency subband signal corresponds to the target energy associated with the particular target interval.", "This may be achieved by determining a different envelope adjustment value for each high frequency subband signal within the particular target interval.", "A different envelope adjustment value may be determined based on the energy of the particular high frequency subband signal and the target energy corresponding to the particular target interval.", "In an embodiment, an envelope adjustment value for a particular high frequency subband signal is determined based on the ratio of the target energy and the energy of the particular high frequency subband signal.", "The system may further comprise means for receiving control data.", "The control data may be indicative of whether to apply the plurality of spectral gain coefficients to generate the plurality of high frequency subband signals.", "In other words, the control data may be indicative of whether the additional gain adjustment of the low frequency subband signals is to be performed or not.", "Alternatively or in addition, the control data may be indicative of a method which is to be used for determining the plurality of spectral gain coefficients.", "By way of example, the control data may be indicative of the pre-determined order of the polynomial which is to be used to determine the frequency dependent curve fitted to the energies of the plurality of low frequency subband signals.", "The control data is typically received from a corresponding encoder which analyzes the original audio signal and informs the corresponding decoder or HFR system on how to decode the bitstream.", "According to another aspect, an audio decoder configured to decode a bitstream comprising a low frequency audio signal and comprising a set of target energies describing the spectral envelope of a high frequency audio signal is described.", "In other words, an audio decoder configured to decode a bitstream representative of a low frequency audio signal and representative of a set of target energies describing the spectral envelope of a high frequency audio signal is described.", "The audio decoder may comprise a core decoder and/or transform unit configured to determine a plurality of low frequency subband signals associated with the low frequency audio signal from the bitstream.", "Alternatively or in addition, the audio decoder may comprise a high frequency generation unit according to the system outlined in the present document, wherein the system may be configured to determine a plurality of high frequency subband signals from the plurality of low frequency subband signals and the set of target energies.", "Alternatively or in addition, the decoder may comprise a merging and/or inverse transform unit configured to generate an audio signal from the plurality of low frequency subband signals and the plurality of high frequency subband signals.", "The merging and inverse transform unit may comprise a synthesis filterbank or transform, e.g.", "an inverse QMF filterbank or an inverse FFT.", "According to a further aspect, an encoder configured to generate control data from an audio signal is described.", "The audio encoder may comprise means to analyse the spectral shape of the audio signal and to determine a degree of spectral envelope discontinuities introduced when re-generating a high frequency component of the audio signal from a low frequency component of the audio signal.", "As such, the encoder may comprise certain elements of a corresponding decoder.", "In particular, the encoder may comprise a HFR system as outlined in the present document.", "This would enable the encoder to determine the degree of discontinuities in the spectral envelope which could be introduced to the high frequency component of the audio signal on the decoder side.", "Alternatively or in addition, the encoder may comprise means to generate control data for controlling the re-generation of the high frequency component based on the degree of discontinuities.", "In particular, the control data may correspond to the control data received by the corresponding decoder or the HFR system.", "The control data may be indicative of whether to use the plurality of spectral gain coefficients during the HFR process and/or which pre-determined polynomial order to use in order to determine the plurality of spectral gain coefficients.", "In order to determine this information a ratio of the selected parts of the low frequency interval, i.e.", "the frequency range covered by the plurality of low frequency subband signals, could be determined.", "This ratio information can be determined by e.g.", "studying the lowest frequencies of the lowband, and the highest frequencies of the lowband to assess the spectral variation of the lowband signal that in the decoder subsequently will be used for high frequency reconstruction.", "A high ratio could indicate an increased degree of discontinuity.", "The control data could also be determined using signal type detectors.", "By way of example, the detection of speech signals could indicate an increased degree of discontinuity.", "On the other hand, the detection of prominent sinusoids in the original audio signal could lead to control data indicating that the plurality of spectral gain coefficients should not be used during the HFR process.", "According to another aspect, a method for generating a plurality of high frequency subband signals covering a high frequency interval from a plurality of low frequency subband signals is described.", "The method may comprise the steps of receiving the plurality of low frequency subband signals and/or of receiving a set of target energies.", "Each target energy may cover a different target interval within the high frequency interval.", "Furthermore, each target energy may be indicative of the desired energy of one or more high frequency subband signals lying within the target interval.", "The method may comprise the step of generating the plurality of high frequency subband signals from the plurality of low frequency subband signals and from a plurality of spectral gain coefficients associated with the plurality of low frequency subband signals, respectively.", "Alternatively or in addition, the method may comprise the step of adjusting the energy of the plurality of high frequency subband signals using the set of target energies.", "The step of adjusting the energy may comprise the step of limiting the adjustment of the energy of the high frequency subband signals lying within a limiter interval.", "Typically, the limiter interval covers more than one target interval.", "According to a further aspect, a method for decoding a bitstream representative of or comprising a low frequency audio signal and a set of target energies describing the spectral envelope of a corresponding high frequency audio signal is described.", "Typically, the low frequency and high frequency audio signals correspond to a low frequency and high frequency component of the same original audio signal.", "The method may comprise the step of determining a plurality of low frequency subband signals associated with the low frequency audio signal from the bitstream.", "Alternatively or in addition, the method may comprise the step of determining a plurality of high frequency subband signals from the plurality of low frequency subband signals and the set of target energies.", "This step is typically performed in accordance with the HFR methods outlined in the present document.", "Subsequently, the method may comprise the step of generating an audio signal from the plurality of low frequency subband signals and the plurality of high frequency subband signals.", "According to another aspect, a method for generating control data from an audio signal is described.", "The method may comprise the step of analysing the spectral shape of the audio signal in order to determine a degree of discontinuities introduced when re-generating a high frequency component of the audio signal from a low frequency component of the audio signal.", "Furthermore, the method may comprise the step of generating control data for controlling the re-generation of the high frequency component based on the degree of discontinuities.", "According to a further aspect, a software program is described.", "The software program may be adapted for execution on a processor and for performing the method steps outlined in the present document when carried out on a computing device.", "According to another aspect, a storage medium is described.", "The storage medium may comprise a software program adapted for execution on a processor and for performing the method steps outlined in the present document when carried out on a computing device.", "According to a further aspect, a computer program product is described.", "The computer program may comprise executable instructions for performing the method steps outlined in the present document when executed on a computer.", "It should be noted that the methods and systems including their preferred embodiments as outlined in the present patent application may be used stand-alone or in combination with the other methods and systems disclosed in this document.", "Furthermore, all aspects of the methods and systems outlined in the present patent application may be arbitrarily combined.", "In particular, the features of the claims may be combined with one another in an arbitrary manner.", "BRIEF DESCRIPTION OF THE DRAWINGS The invention is explained below by way of illustrative examples with reference to the accompanying drawings, wherein FIG.", "1a illustrates the absolute spectrum of an example high band signal prior to spectral envelope adjustment; FIG.", "1b illustrates an exemplary relation between time-frames of audio data and envelope time borders of the spectral envelopes; FIG.", "1c illustrates the absolute spectrum of an example high band signal prior to spectral envelope adjustment, and the corresponding scalefactor bands, limiter bands, and HF (high frequency) patches; FIG.", "2 illustrates an embodiment of a HFR system where the copy-up process is complemented with an additional gain adjustment step; FIG.", "3 illustrates an approximation of the coarse spectral envelope of an example lowband signal; FIG.", "4 illustrates an embodiment of an additional gain adjuster operating on optional control data, the QMF subbands samples, and outputting a gain curve; FIG.", "5 illustrates a more detailed embodiment of the additional gain adjuster of FIG.", "4; FIG.", "6 illustrates an embodiment of an HFR system with a narrowband signal as input and a wideband signal as output; FIG.", "7 illustrates an embodiment of an HFR system incorporated into the SBR module of an audio decoder; FIG.", "8 illustrates an embodiment of the high frequency reconstruction module of an example audio decoder; FIG.", "9 illustrates an embodiment of an example encoder; FIG.", "10a illustrates the spectrogram of an example vocal segment which has been decoded using a conventional decoder; FIG.", "10b illustrates the spectrogram of the vocal segment of FIG.", "10a, which has been decoded using a decoder applying the additional gain adjustment processing; and FIG.", "10c illustrates the spectrogram of the vocal segment of FIG.", "10a for the original un-coded signal.", "DESCRIPTION OF PREFERRED EMBODIMENTS The below-described embodiments are merely illustrative for the principles of the present invention PROCESSING OF AUDIO SIGNALS DURING HIGH FREQUENCY RECONSTRUCTION.", "It is understood that modifications and variations of the arrangements and the details described herein will be apparent to others skilled in the art.", "It is the intent, therefore, to be limited only by the scope of the impending patent claims and not by the specific details presented by way of description and explanation of the embodiments herein.", "As outlined above, audio decoders using HFR techniques typically comprise an HFR unit for generating a high frequency audio signal and a subsequent spectral envelope adjustment unit for adjusting the spectral envelope of the high frequency audio signal.", "When adjusting the spectral envelope of the audio signal, this is typically done by means of a filterbank implementation, or by means of time-domain filtering.", "The adjustment can either strive to do a correction of the absolute spectral envelope, or it can be performed by means of filtering which also corrects phase characteristics.", "Either way, the adjustment is typically a combination of two steps, the removal of the current spectral envelope, and the application of the target spectral envelope.", "It is important to note, that the methods and systems outlined in the present document are not merely directed at the removal of the spectral envelope of the audio signal.", "The methods and systems strive to do a suitable spectral correction of the spectral envelope of the lowband signal as part of the high frequency regeneration step, in order to not introduce spectral envelope discontinuities of the high frequency spectrum created by combining different segments of the lowband, i.e.", "of the low frequency signal, shifted or transposed to different frequency ranges of the highband, i.e.", "of the high frequency signal.", "In FIG.", "1a a stylistically drawn spectrum 100, 110 of the output of an HFR unit is displayed, prior to going into the envelope adjuster.", "In the top-panel, a copy-up method (with two patches) is used to generate the highband signal 105 from the lowband signal 101, e.g.", "the copy-up method used in MPEG-4 SBR (Spectral Band Replication) which is outlined in “ISO/IEC 14496-3 Information Technology—Coding of audio-visual objects—Part 3: Audio” and which is incorporated by reference.", "The copy-up method translates parts of the lower frequencies 101 to higher frequencies 105.In the lower panel, a harmonic transposition method (with two patches) is used to generate the highband signal 115 from the lowband signal 111, e.g.", "the harmonic transposition method of MPEG-D USAC which is described in “MPEG-D USAC: ISO/IEC 23003-3—Unified Speech and Audio Coding” and which is incorporated by reference.", "In the subsequent envelope adjustment stage, a target spectral envelope is applied onto the high frequency components 105, 115.As can be seen from the spectrum 105, 115 going into the envelope adjuster, discontinuities (notably at the patch borders) can be observed in the spectral shape of the highband excitation signal 105, 115, i.e.", "of the highband signal entering the envelope adjuster.", "These discontinuities originate from the fact that several contributions of the low frequencies 101, 111 are used in order to generate the highband 105, 115.As can be seen, the spectral shape of the highband signal 105, 115 is related to the spectral shape of the lowband signal 101, 111.Consequently, particular spectral shapes of the lowband signal 101, 111, e.g.", "a gradient shape illustrated in FIG.", "1a, may lead to discontinuities in the overall spectrum 100, 110.In addition to the spectrum 100, 110, FIG.", "1a illustrates example frequency bands 130 of the spectral envelope data representing the target spectral envelope.", "These frequency bands 130 are referred to as scalefactor bands or target intervals.", "Typically, a target energy value, i.e.", "a scalefactor energy, is specified for each target interval, i.e.", "scalefactor band.", "In other words, the scalefactor bands define the effective frequency resolution of the target spectral envelope, as there is typically only a single target energy value per target interval.", "Using the scalefactors or target energies specified for the scalefactor bands, the subsequent envelope adjuster strives to adjust the highband signal so that the energy of the highband signal within the scalefactor bands equals the energy of the received spectral envelope data, i.e.", "the target energy, for the respective scalefactor bands.", "In FIG.", "1c a more detailed description is provided using an example audio signal.", "In the plot, the spectrum of a real-world audio signal 121 going into the envelope adjuster is depicted, as well as the corresponding original signal 120.In this particular example, the SBR range, i.e.", "the range of the high frequency signal, starts at 6.4 kHz, and consists of three different replications of the lowband frequency range.", "The frequency ranges of the different replications are indicated by “patch 1”, “patch 2”, and “patch 3”.", "It is clear from the spectrogram that the patching introduces discontinuities in the spectral envelope at around 6.4 kHz, 7.4 kHz, and 10.8 kHz.", "In the present example, these frequencies correspond to the patch borders.", "FIG.", "1c further illustrates the scalefactor bands 130 as well as the limiter bands 135, of which the function will be outlined in more detail in the following.", "In the illustrated embodiment, the envelope adjuster of the MPEG-4 SBR is used.", "This envelope adjuster operates using a QMF filterbank.", "The main aspects of the operation of such an envelope adjuster are: to calculate the mean energy across a scalefactor band 130 of the input signal to the envelope adjuster, i.e.", "the signal coming out of the HFR unit; in other words, the mean energy of the regenerated highband signal is calculated within each scalefactor band/target interval 130; to determine a gain value, also referred to as envelope adjustment value, for each scalefactor band 130, wherein the envelope adjustment value is the square root of the energy ratio between the target energy (i.e.", "the energy target received from an encoder), and the mean energy of the regenerated highband signal 121 within the respective scalefactor band 130; to apply the respective envelope adjustment value to the frequency band of the regenerated highband signal 121, wherein the frequency band corresponds to the respective scalefactor band 130.Furthermore, the envelope adjuster may comprise additional steps and variations, in particular: a limiter functionality, which limits the maximum allowed envelope adjustment value to be applied over a certain frequency band, i.e.", "over a limiter band 135.The maximum allowed envelope adjustment value is a function of the envelope adjustment values determined for the different scalefactor bands 130 which fall within a limiter band 135.In particular, the maximum allowed envelope adjustment value is a function of the mean of the envelope adjustment values determined for the different scalefactor bands 130 which fall within a limiter band 135.By way of example, the maximum allowed envelope adjustment value may be the mean value of the relevant envelope adjustment values multiplied by a limiter factor (such as 1.5).", "The limiter functionality is typically applied in order to limit the introduction of noise into the regenerated highband signal 121.This is particularly relevant for audio signals comprising prominent sinusoids, i.e.", "audio signals having a spectrum with distinct peaks at certain frequencies.", "Without the use of the limiter functionality, significant envelope adjustment values would be determined for the scalefactor bands 130 for which the original audio signal comprises such distinct peaks.", "As a result, the spectrum of the complete scalefactor band 130 (and not only the distinct peak) would be adjusted, thereby introducing noise.", "an interpolation functionality, which allows the envelope adjustment values to be calculated for each individual QMF subband within a scalefactor band, instead of calculating a single envelope adjustment value for the entire scalefactor band.", "Since the scalefactor bands typically comprise more than one QMF subband, an envelope adjustment value can be calculated as the ratio of the energy of a particular QMF subband within the scalefactor band and the target energy received from the encoder, instead of calculating the ratio of the mean energy of all QMF subbands within the scalefactor band and the target energy received from the encoder.", "As such, a different envelope adjustment value may be determined for each QMF subband within a scalefactor band.", "It should be noted that the received target energy value for a scalefactor band typically corresponds to the average energy of that frequency range within the original signal.", "It is up to the decoder operation how to apply the received average target energy to the corresponding frequency band of the regenerated highband signal.", "This can be done by applying an overall envelope adjustment value to the QMF subbands within a scalefactor band of the regenerated highband signal or by applying an individual envelope adjustment value to each QMF subband.", "The latter approach can be thought of as if the received envelope information (i.e.", "one target energy per scalefactor band) was “interpolated” across the QMF subbands within a scalefactor band in order to provide a higher frequency resolution.", "Hence, this approach is referred to as “interpolation” in MPEG-4 SBR.", "Returning to FIG.", "1c it can be seen that the envelope adjuster would have to apply high envelope adjustment values in order to match the spectrum 121 of the signal going into the envelope adjuster with the spectrum 120 of the original signal.", "It can also be seen that due to the discontinuities, large variations of envelope adjustment values occur within the limiter bands 135.As a result of such large variations, the envelope adjustment values which correspond to the local minima of the regenerated spectrum 121 will be limited by the limiter functionality of the envelope adjuster.", "As a result, the discontinuities within the re-generated spectrum 121 will remain, even after performing the envelope adjustment operation.", "On the other hand, if no limiter functionality is used, undesirable noise may be introduced as outlined above.", "Hence, a problem for the re-generation of a highband signal occurs for any signal that has large variations in level over the lowband range.", "This problem is due to the discontinuities introduced during the high frequency re-generation of the highband.", "When subsequently the envelope adjuster is exposed to this re-generated signal, it cannot with reasonability and consistence separate the newly introduced discontinuity from any “real-world” spectral characteristic of the lowband signal.", "The effects of this problem are two-fold.", "First, spectral shapes are introduced in the highband signal that the envelope adjuster cannot compensate for.", "Consequently, the output has the wrong spectral shape.", "Second, an instability effect is perceived, due to the fact that this effect comes and goes as a function of the lowband spectral characteristics.", "The present document addresses the above mentioned problem by describing a method and system which provide an HFR highband signal at the input of the envelope adjuster which does not exhibit spectral discontinuities.", "For this purpose, it is proposed to remove or reduce the spectral envelope of the lowband signal when performing high frequency regeneration.", "By doing this, one will avoid to introduce any spectral discontinuities into the highband signal prior to performing envelope adjustment.", "As a result, the envelope adjuster will not have to handle such spectral discontinuities.", "In particular, a conventional envelope adjuster may be used, wherein the limiter functionality of the envelope adjuster is used to avoid the introduction of noise into the regenerated highband signal.", "In other words, the described method and system may be used to re-generate an HFR highband signal having little or no spectral discontinuities and a low level of noise.", "It should be noted that the time-resolution of the envelope adjuster may be different from the time resolution of the proposed processing of the spectral envelope during the highband signal generation.", "As indicated above, the processing of the spectral envelope during the highband signal re-generation is intended to modify the spectral envelope of the lowband signal, in order to alleviate the processing within the subsequent envelope adjuster.", "This processing, i.e.", "the modification of the spectral envelope of the lowband signal, may be performed e.g.", "once per audio frame, wherein the envelope adjuster may adjust the spectral envelope over several time intervals, i.e.", "using several received spectral envelopes.", "This is outlined in FIG.", "1b where the time-grid 150 of the spectral envelope data is depicted in the top panel, and the time-grid 155 for the processing of the spectral envelope of the lowband signal during highband signal re-generation is depicted in the lower panel.", "As can be seen in the example of FIG.", "1b, the time-borders of the spectral envelope data varies over time, while the processing of the spectral envelope of the lowband signal operates on a fixed time-grid.", "It can also be seen that several envelope adjustment cycles (represented by the time-borders 150) may be performed during one cycle of processing of the spectral envelope of the lowband signal.", "In the illustrated example, the processing of the spectral envelope of the lowband signal operates on a frame by frame basis, meaning that a different plurality of spectral gain coefficients is determined for each frame of the signal.", "It should be noted that the processing of the lowband signal may operate on any time-grid, and that the time-grid of such processing does not have to coincide with the time-grid of the spectral envelope data.", "In FIG.", "2, a filterbank based HFR system 200 is depicted.", "The HFR system 200 operates using a pseudo-QMF filterbank and the system 200 may be used to produce the highband and lowband signal 100 illustrated on the top panel of FIG.", "1a.", "However, an additional step of gain adjustment has been added as part of the High Frequency Generation process, which in the illustrated example is a copy-up process.", "The low frequency input signal is analyzed by a 32 subband QMF 201 in order to generate a plurality of low frequency subband signals.", "Some or all of the low frequency subband signals are patched to higher frequency locations according to a HF (high frequency) generation algorithm.", "Additionally, the plurality of low frequency subbands is directly input to the synthesis filterbank 202.The aforementioned synthesis filterbank 202 is a 64 subband inverse QMF 202.For the particular implementation illustrated in FIG.", "2, the use of a 32 subband QMF analysis filterbank 201 and the use of a 64 subband QMF synthesis filterbank 202 will yield an output sampling rate of the output signal of twice the input sampling rate of the input signal.", "It should be noted, however, that the systems outlined in the present document are not limited to systems with different input and output sampling rates.", "A multitude of different sampling rate relations can be envisioned by those skilled in the art.", "As outlined in FIG.", "2, the subbands from the lower frequencies are mapped to subbands of higher frequencies.", "A gain adjustment stage 204 is introduced as part of this copy-up process.", "The created high frequency signal, i.e.", "the generated plurality of high frequency subband signals, is input to the envelope adjuster 203 (possibly comprising a limiter and/or interpolation functionality), prior to combination with the plurality of low frequency subband signals in the synthesis filterbank 202.By using such an HFR system 200, and in particular by using a gain adjustment stage 204, the introduction of spectral envelope discontinuities as illustrated in FIG.", "1 can be avoided.", "For this purpose, the gain adjustment stage 204 modifies the spectral envelope of the lowband signal, i.e.", "the spectral envelope of the plurality of low frequency subband signals, such that the modified lowband signal can be used to generate a highband signal, i.e.", "a plurality of high frequency subband signals, which does not exhibit discontinuities, notably discontinuities at the patch borders.", "Referring to FIG.", "1c, the additional gain adjustment stage 204 ensures that the spectral envelope 101, 111 of the lowband signal is modified such that there are no, or limited, discontinuities in the generated highband signal 105, 115.The modification of the spectral envelope of the lowband signal can be achieved by applying a gain curve to the spectral envelope of the lowband signal.", "Such a gain curve can be determined by a gain curve determination unit 400 illustrated in FIG.", "4.The module 400 takes as input the QMF data 402 corresponding to the frequency range of the lowband signal used for re-creating the highband signal.", "In other words, the plurality of low frequency subband signals is input to the gain curve determination unit 400.As already indicated, only a subset of the available QMF subbands of the lowband signal may be used to generate the highband signal, i.e.", "only a subset of the available QMF subbands may be input to the gain curve determination unit 400.In addition, the module 400 may receive optional control data 404, e.g.", "control data sent from a corresponding encoder.", "The module 400 outputs a gain curve 403 which is to be applied during the high frequency regeneration process.", "In an embodiment, the gain curve 403 is applied to the QMF subbands of the lowband signal, which are used to generate the highband signal.", "I.e.", "the gain curve 403 may be used within the copy-up process of the HFR process.", "The optional control data 404 may comprise information on the resolution of the coarse spectral envelope which is to be estimated in the module 400, and/or information on the suitability of applying the gain-adjustment process.", "As such, the control data 404 may control the amount of additional processing involved during the gain-adjustment process.", "The control data 404 may also trigger a by-pass of the additional gain adjustment processing, if signals occur that do not lend themselves well to coarse spectral envelope estimation, e.g.", "signals comprising single sinusoids.", "In FIG.", "5 a more detailed view of the module 400 in FIG.", "4 is outlined.", "The QMF data 402 of the lowband signal is input to an envelope estimation unit 501 that estimates the spectral envelope, e.g.", "on a logarithmic energy scale.", "The spectral envelope is subsequently input to a module 502 that estimates the coarse spectral envelope from the high (frequency) resolution spectral envelope received from the envelope estimation unit 501.In one embodiment, this is done by fitting a low order polynomial to the spectral envelope data, i.e.", "a polynomial of an order in the range of e.g.", "1, 2, 3, or 4.The coarse spectral envelope may also be determined by performing a moving average operation of the high resolution spectral envelope along the frequency axis.", "The determination of a coarse spectral envelope 301 of a lowband signal is visualized in FIG.", "3.It can be seen that the absolute spectrum 302 of the lowband signal, i.e.", "the energy of the QMF bands 302, is approximated by a coarse spectral envelope 301, i.e.", "by a frequency dependent curve fitted to the spectral envelope of the plurality of low frequency subband signals.", "Furthermore, it is shown that only 20 QMF subband signals are used for generating the highband signal, i.e.", "only a part of the 32 QMF subband signals are used within the HFR process.", "The method used for determining the coarse spectral envelope from the high resolution spectral envelope and in particular the order of the polynomial which is fitted to the high resolution spectral envelope can be controlled by the optional control data 404.The order of the polynomial may be a function of the size of the frequency range 302 of the lowband signal for which a coarse spectral envelope 301 is to be determined, and/or it may be a function of other parameters relevant for the overall coarse spectral shape of the relevant frequency range 302 of the lowband signal.", "The polynomial fitting calculates a polynomial that approximates the data in a least square error sense.", "In the following, a preferred embodiment is outlined, by means of Matlab code: function GainVec = calculateGainVec(LowEnv) %% function GainVec = calculateGainVec(LowEnv) % Input: Lowband envelope energy in dB % Output: gain vector to be applied to the lowband prior to HF- % generation % % The function does a low order polynomial fitting of the low band % spectral envelope, as a representation of the lowband overall % spectral slope.", "The overall slope according to this is subsequently % translated into a gain vector that can be applied prior to HF- % generation to remove the overall slope (or coarse spectral shape).", "% % This prevents that the HF generation introduces discontinuities in % the spectral shape, that will be ″confusing″ for the subsequent % envelope adjustment and limiter-process.", "The ″confusion″ occurs when % the envelope adjuster and limiter needs to take care of a large dis- % continuity, and thus a large gain value.", "It is very difficult to % tune and have a proper operation of these modules if they are to % take care of both ″natural″ variations in the highband as well as % the ″artificial″ variations introduced by the HF generation process.", "polyOrderWhite = 3; x_lowBand = 1:length(LowEnv); p=polyfit(x_lowBand,LowEnv,polyOrderWhite); lowBandEnvSlope = zeros(size(x_lowBand)); for k=polyOrderWhite:−1:0 tmp = (x_lowBand.", "{circumflex over ( )}k).", "*p(polyOrderWhite − k + 1); lowBandEnvSlope = lowBandEnvSlope + tmp; end GainVec = 10.", "{circumflex over ( )}((mean(LowEnv) − lowBandEnvSlope)./20); In the above code, the input is the spectral envelope (LowEnv) of the lowband signal obtained by averaging QMF subband samples on a per subband basis over a time-interval corresponding to the current time frame of data operated on by the subsequent envelope adjuster.", "As indicated above, the gain-adjustment processing of the lowband signal may be performed on various other time-grids.", "In the above example, the estimated absolute spectral envelope is expressed in a logarithmic domain.", "A polynomial of low order, in the above example a polynomial of order 3, is fitted to the data.", "Given the polynomial, a gain curve (GainVec) is calculated from the difference in mean energy of the lowband signal and the curve (lowBandEnvSlope)) obtained from the polynomial fitted to the data.", "In the above example, the operation of determining the gain curve is done in the logarithmic domain.", "The gain curve calculation is performed by the gain curve calculation unit 503.As indicated above, the gain curve may be determined from the mean energy of the part of the lowband signal used to re-generate the highband signal, and from the spectral envelope of the part of the lowband signal used to re-generate the highband signal.", "In particular, the gain curve may be determined from the difference of the mean energy and the coarse spectral envelope, represented e.g.", "by a polynomial.", "I.e.", "the calculated polynomial may be used to determine a gain curve which comprises a separate gain value, also referred to as a spectral gain coefficient, for every relevant QMF subband of the lowband signal.", "This gain curve comprising the gain values is subsequently used in the HFR process.", "As an example, an HFR generation process in accordance to MPEG-4 SBR is described next.", "The HF generated signal may be derived by the following formula (see document MPEG-4 Part 3 (ISO/IEC 14496-3), sub-part 4, section 4.6.18.6.2, which is incorporated by reference): XHigh(k,l+tHFAdj)=XLow(p,l+tHFadj)+bwArray(g(k))·α0(p)·Xlow(p,l−1+tHFAdj)+[bwArray(g(k))]2·α1(p)·XLow(p,l−2+tHFadj), wherein p is the subband index of the lowband signal, i.e.", "p identifies one of the plurality of low frequency subband signals.", "The above HF generation formula may be replaced by the following formula which performs a combined gain adjustment and HF generation: XHigh(k,l+tHFAdj)=preGain(p)·(XLow(p,l+tHFadj)) +bwArray(g(k))·α0(p)·XLow(p,l−1+tHFadj) +[bwArray(g(k))]2·α1(p)·XLow(p,l−2+tHFadj) wherein the gain curve is referred to as preGain(p).", "Further details of the copy-up process, e.g.", "with regards to the relation between p and k, are specified in the above mentioned MPEG-4, Part 3 document.", "In the above formula, XLow(p,l) indicates a sample at time instance l of the low frequency subband signal having a subband index p. This sample in combination with preceding samples is used to generate a sample of the high frequency subband signal XHigh(k, l) having a subband index k. It should be noted that the aspect of gain adjustment can be used in any filterbank based high frequency reconstruction system.", "This is illustrated in FIG.", "6 where the present invention is part of a standalone HFR unit 601 that operates on a narrowband or lowband signal 602 and outputs a wideband or highband signal 604.The module 601 may receive additional control data 603 as input, wherein the control data 603 may specify, among other things, the amount of processing used for the described gain adjustment, as well as e.g.", "information on the target spectral envelope of the highband signal.", "However, these parameters are only examples of optional control data 603.In an embodiment, relevant information may also be derived from the narrow band signal 602 input to the module 601, or by other means.", "I.e.", "the control data 603 may be determined within the module 601 based on the information available at the module 601.It should be noted that the standalone HFR unit 601 may receive the plurality of low frequency subband signals and may output the plurality of high frequency subband signals, i.e.", "the analysis/synthesis filterbanks or transforms may be placed outside the HFR unit 601.As already indicated above, it may be beneficial to signal the activation of the gain adjustment processing in the bitstream from an encoder to a decoder.", "For certain signal types, e.g.", "a single sinusoid, the gain adjustment processing may not be relevant and it may therefore be beneficial to enable the encoder/decoder system to turn the additional processing off in order to not introduce an unwanted behaviour for such corner case signals.", "For this purpose, the encoder may be configured to analyze the audio signals and to generate control data which turns on and off the gain adjustment processing at the decoder.", "In FIG.", "7 the proposed gain adjustment stage is included in a high frequency reconstruction unit 703 which is part of an audio codec.", "One example of such a HFR unit 703 is the MPEG-4 Spectral Band Replication tool used as part of the High Efficiency AAC codec or the MPEG-D USAC (Unified Speech and Audio Codec).", "In this embodiment a bitstream 704 is received at an audio decoder 700.The bitstream 704 is de-multiplexed in de-multiplexer 701.The SBR relevant part of the bitstream 708 is fed to the SBR module or HFR unit 703, and the core coder relevant bitstream 707, e.g.", "AAC data or USAC core decoder data, is sent to the core coder module 702.In addition, the lowband or narrow band signal 706 is passed from the core decoder 702 to the HFR unit 703.The present invention is incorporated as part of the SBR-process in HFR unit 703, e.g.", "in accordance to the system outlined in FIG.", "2.The HFR unit 703 outputs a wideband or highband signal 705 using the processing outlined in the present document.", "In FIG.", "8, an embodiment of the high frequency reconstruction module 703 is outlined in more detail.", "FIG.", "8 illustrates that the HF (high frequency) signal generation may be derived from different HF generation modules at different instances in time.", "The HF generation may be based either on a QMF based copy-up transposer 803, or the HF generation may be based on a FFT based harmonic transposer 804.For both HF signal generation modules, the lowband signal is processed 801, 802 as part of the HF generation in order to determine a gain curve which is used in the copy-up 803 or harmonic transposition 804 process.", "The outputs from the two transposers are selectively input to the envelope adjuster 805.The decision on which transposer signal to use is controlled by the bitstream 704 or 708.It should be noted that, due to the copy-up nature of the QMF based transposer, the shape of the spectral envelope of the lowband signal is maintained more clearly than when using a harmonic transposer.", "This will typically result in more distinct discontinuities of the spectral envelope of the highband signal when using copy-up transposers.", "This is illustrated in the top and bottom panels of FIG.", "1a.", "Consequently, it may be sufficient to only incorporate the gain adjustment for the QMF-based copy-up method performed in module 803.Nevertheless, applying the gain adjustment for the harmonic transposition performed in module 804 may be beneficial as well.", "In FIG.", "9, a corresponding encoder module is outlined.", "The encoder 901 may be configured to analyse the particular input signal 903 and determine the amount of gain adjustment processing which is suitable for the particular type of input signal 903.In particular, the encoder 901 may determine the degree of discontinuity on the high frequency subband signal which will be caused by the HFR unit 703 at the decoder.", "For this purpose, the encoder 901 may comprise an HFR unit 703, or at least relevant parts of the HFR unit 703.Based on the analysis of the input signal 903, control data 905 can be generated for the corresponding decoder.", "The information 905, which concerns the gain adjustment to be performed at the decoder, is combined in multiplexer 902 with audio bitstream 906, thereby forming the complete bitstream 904 which is transmitted to the corresponding decoder.", "In FIG.", "10, the output spectra of a real world signal are displayed.", "In FIG.", "10 a, the output of a MPEG USAC decoder decoding a 12 kbps mono bitstream is depicted.", "The section of the real world signal is a vocal part of an a cappella recording.", "The abscissa corresponds to the time axis, whereas the ordinate corresponds to the frequency axis.", "Comparing the spectrogram of FIG.", "10a to FIG.", "10c which displays the corresponding spectrogram of the original signal, it is clear that there are holes (see reference numerals 1001, 1002) appearing in the spectrum for the fricative parts of the vocal segment.", "In FIG.", "10b the spectrogram of the output of the MPEG USAC decoder including the present invention is depicted.", "It can be seen from the spectrogram that the holes in the spectrum have disappeared (see the reference numerals 1003, 1004 corresponding to the reference numerals 1001, 1002.The complexity of the proposed gain adjustment algorithm was calculated as weighted MOPS, where functions like POW/DIV/TRIG are weighted as 25 operations, and all other operations are weighted as one operation.", "Given these assumptions, the calculated complexity amounts to approximately 0.1 WMOPS and insignificant RAM/ROM usage.", "In other words, the proposed gain adjustment processing requires low processing and memory capacity.", "In the present document, a method and system for generating a highband signal from a lowband signal have been described.", "The method and system are adapted to generate a highband signal with little or no spectral discontinuities, thereby improving the perceptual performance of high frequency reconstruction methods and systems.", "The method and system can be easily incorporated into existing audio encoding/decoding systems.", "In particular, the method and system can be incorporated without the need to modify the envelope adjustment processing of existing audio encoding/decoding systems.", "Notably this applies to the limiter and interpolation functionality of the envelope adjustment processing which can perform their intended tasks.", "As such, the described method and system may be used to re-generate highband signals having little or no spectral discontinuities and a low level of noise.", "Furthermore, the use of control data has been described, wherein the control data may be used to adapt the parameters of the described method and system (and the computational complexity) to the type of audio signal.", "The methods and systems described in the present document may be implemented as software, firmware and/or hardware.", "Certain components may e.g.", "be implemented as software running on a digital signal processor or microprocessor.", "Other components may e.g.", "be implemented as hardware and or as application specific integrated circuits.", "The signals encountered in the described methods and systems may be stored on media such as random access memory or optical storage media.", "They may be transferred via networks, such as radio networks, satellite networks, wireless networks or wireline networks, e.g.", "the internet.", "Typical devices making use of the methods and systems described in the present document are portable electronic devices or other consumer equipment which are used to store and/or render audio signals.", "The methods and systems may also be used on computer systems, e.g.", "internet web servers, which store and provide audio signals, e.g.", "music signals, for download." ] ]
Patent_15872836
[ [ "OPTIMIZING RESOURCE ALLOCATION FOR PROJECTS EXECUTING IN A CLOUD-BASED ENVIRONMENT", "Embodiments are directed towards a system and method for a cloud-based front end that may abstract and enable access to the underlying cloud-hosted elements and objects that may be part of a multi-tenant application, such as a search application.", "Search objects may be employed to access indexed objects.", "An amount of indexed data accessible to a user may be based on an index storage limit selected by the user, such that data that exceeds the index storage limit may continue to be indexed.", "Also, one or more projects can be elastically scaled for a user to provide resources that may meet the specific needs of each project." ], [ "1.A method comprising: identifying a resource allocation associated with a project, wherein the resource allocation identifies a plurality of computing resources assigned to the project for indexing data corresponding to the project; determining based on one or more performance rules associated with the project that the resource allocation is suboptimal; determining an optimal resource allocation for the project based on one or more characteristics of the project; and adjusting the plurality of computing resources based on the optimal resource allocation.", "2.The method of claim 1, wherein the project is associated with an index store for storing the data corresponding to the project, the index store is accessible by at least one indexer server, and the at least one indexer server is associated with at least one virtual machine.", "3.The method of claim 1, wherein the one or more performance rules specifies an optimal speed for indexing data corresponding to the project.", "4.The method of claim 1, wherein the one or more performance rules includes a rule-based trigger that is triggered when a speed for indexing the data corresponding to the project falls below a threshold.", "5.The method of claim 1, wherein the one or more performance rules indicates a scheduled trigger for changing the plurality of computing resources assigned to the project.", "6.The method of claim 1, wherein determining the optimal resource allocation comprises determining a change in a first subset of the plurality of computing resources associated with a first processing dimension based on a performance characteristic of the project.", "7.The method of claim 1, wherein determining the optimal resource allocation comprises: determining a first change in a first subset of the plurality of computing resources associated with a first processing dimension based on a performance characteristic of the project; and determining, based on the first change, a second change in a second subset of the plurality of computing resources associated with a second processing dimension.", "8.The method of claim 1, wherein adjusting the plurality of computing resources comprises placing a request to adjust the plurality of computing resources in a request queue until the request can be fulfilled.", "9.The method of claim 1, further comprising: determining an impact of the optimal resource allocation on an overall performance of an indexing system that indexes data corresponding to a plurality of projects including the project; and delaying a request to adjust the plurality of computing resources until the request based on the impact.", "10.The method of claim 1, further comprising causing a user interface to display at least one user interface control to adjust at least one parameter related to the project, and determining the optimal resource allocation in response to input from the at least one user interface control.", "11.A computer readable storing medium comprising instructions that, when executed by a processor, cause the processor to: identify a resource allocation associated with a project, wherein the resource allocation identifies a plurality of computing resources assigned to the project for indexing data corresponding to the project; determine based on one or more performance rules associated with the project that the resource allocation is suboptimal; determine an optimal resource allocation for the project based on one or more characteristics of the project; and adjust the plurality of computing resources based on the optimal resource allocation.", "12.The computer readable storing medium of claim 11, wherein the project is associated with an index store for storing the data corresponding to the project, the index store is accessible by at least one indexer server, and the at least one indexer server is associated with at least one virtual machine.", "13.The computer readable storing medium of claim 11, wherein the one or more performance rules specifies an optimal speed for indexing data corresponding to the project.", "14.The computer readable storing medium of claim 11, wherein the one or more performance rules includes a rule-based trigger that is triggered when a speed for indexing the data corresponding to the project falls below a threshold.", "15.The computer readable storing medium of claim 11, wherein the one or more performance rules indicates a scheduled trigger for changing the plurality of computing resources assigned to the project.", "16.The computer readable storing medium of claim 11, wherein determining the optimal resource allocation comprises determining a change in a first subset of the plurality of computing resources associated with a first processing dimension based on a performance characteristic of the project.", "17.The computer readable storing medium of claim 11, wherein determining the optimal resource allocation comprises: determining a first change in a first subset of the plurality of computing resources associated with a first processing dimension based on a performance characteristic of the project; and determining, based on the first change, a second change in a second subset of the plurality of computing resources associated with a second processing dimension.", "18.The computer readable storing medium of claim 11, wherein adjusting the plurality of computing resources comprises placing a request to adjust the plurality of computing resources in a request queue until the request can be fulfilled.", "19.The computer readable storing medium of claim 11, wherein the instructions, when executed by the processor, further cause the processor to: determine an impact of the optimal resource allocation on an overall performance of an indexing system that indexes data corresponding to a plurality of projects including the project; and delay a request to adjust the plurality of computing resources until the request based on the impact.", "20.The computer readable storing medium of claim 11, wherein the instructions, when executed by the processor, further cause the processor to cause a user interface to display at least one user interface control to adjust at least one parameter related to the project, and determining the optimal resource allocation in response to input from the at least one user interface control.", "21.A computer system comprising: a memory storing instructions; and a processor for executing the instructions to perform the steps of: identifying a resource allocation associated with a project, wherein the resource allocation identifies a plurality of computing resources assigned to the project for indexing data corresponding to the project; determining based on one or more performance rules associated with the project that the resource allocation is suboptimal; determining an optimal resource allocation for the project based on one or more characteristics of the project; and adjusting the plurality of computing resources based on the optimal resource allocation.", "22.The computer system of claim 21, wherein the project is associated with an index store for storing the data corresponding to the project, the index store is accessible by at least one indexer server, and the at least one indexer server is associated with at least one virtual machine.", "23.The computer system of claim 21, wherein the one or more performance rules specifies an optimal speed for indexing data corresponding to the project.", "24.The computer system of claim 21, wherein the one or more performance rules includes a rule-based trigger that is triggered when a speed for indexing the data corresponding to the project falls below a threshold.", "25.The computer system of claim 21, wherein the one or more performance rules indicates a scheduled trigger for changing the plurality of computing resources assigned to the project.", "26.The computer system of claim 21, wherein determining the optimal resource allocation comprises determining a change in a first subset of the plurality of computing resources associated with a first processing dimension based on a performance characteristic of the project.", "27.The computer system of claim 21, wherein determining the optimal resource allocation comprises: determining a first change in a first subset of the plurality of computing resources associated with a first processing dimension based on a performance characteristic of the project; and determining, based on the first change, a second change in a second subset of the plurality of computing resources associated with a second processing dimension.", "28.The computer system of claim 21, wherein adjusting the plurality of computing resources comprises placing a request to adjust the plurality of computing resources in a request queue until the request can be fulfilled.", "29.The computer system of claim 21, wherein the processor further performs the steps of: determining an impact of the optimal resource allocation on an overall performance of an indexing system that indexes data corresponding to a plurality of projects including the project; and delaying a request to adjust the plurality of computing resources until the request based on the impact.", "30.The computer system of claim 21, wherein the processor further performs the step of causing a user interface to display at least one user interface control to adjust at least one parameter related to the project, and determining the optimal resource allocation in response to input from the at least one user interface control." ], [ "<SOH> BACKGROUND <EOH>Many companies install and maintain software for use on a variety of distributed systems that can range from a single computer for a small business to a collection of servers and a plurality of user computer nodes for a large corporation.", "Also, the volume of data processed by a node in a small business can be a magnitude less than the volume of data processed by a node in a large corporation.", "Further, at different times the amount of data to be indexed for searching and the need for speed to search the indexed data can vary.", "Additionally, the type of data processed by large and small business can vary widely, such as sending and receiving messages, creating and storing documents, hosting web sites, database searches, facilitating online transactions, and the like.", "Furthermore, the expense of developing and maintaining software that can handle the type and volume of data processed by a large corporation can be substantially greater than the effort expended to do somewhat the same for a small business.", "Consequently, cloud-based systems that provide software as a service are increasingly popular with different sizes of businesses having different volumes of data and types of data." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>Non-limiting and non-exhaustive embodiments are described with reference to the following drawings.", "In the drawings, like reference numerals refer to like parts throughout the various figures unless otherwise specified.", "For a better understanding, reference will be made to the following Detailed Description, which is to be read in association with the accompanying drawings, wherein: FIG.", "1 illustrates a system environment in which various embodiments may be implemented; FIG.", "2A shows a rack of blade servers that may be included in various embodiments; FIG.", "2B illustrates an embodiment of a blade server that may be included in a rack of blade servers such as that shown in FIG.", "2A ; FIG.", "3 shows a mobile device that may be included in various embodiments; FIG.", "4 illustrates a network device that may be included in various embodiments; FIG.", "5 illustrates a system diagram showing an embodiment of a system that may be utilized to implement embodiments of processing, searching and managing data volumes; FIG.", "6 illustrates a system diagram showing an alternative embodiment of a system that may be utilized to implement embodiments of processing, searching and managing data volumes; FIG.", "7 illustrates a logical flow diagram generally showing one embodiment of an overview process for initiating a project that employs embodiments of the system diagrams shown in FIGS.", "5 and/or 6 ; FIG.", "8 illustrates a logical flow diagram generally showing one embodiment of a process for enabling access to a determined volume of data and restricting access to incoming data that exceeds the determined volume; FIG.", "9 illustrates a logical flow diagram generally showing one embodiment of a process for managing an overflow index store; FIG.", "10 illustrates a logical flow diagram generally showing one embodiment of a process for enabling a project owner to invite another user into the project; FIG.", "11 illustrates a logical flow diagram generally showing one embodiment of an overview process for elastically scaling a project; FIG.", "12 illustrates a logical flow diagram generally showing one embodiment of a process for receiving resource allocation direction from an operator manipulating a user interface control; FIG.", "13 illustrates a logical flow diagram generally showing one embodiment of a process for increasing a project's resources as part of elastic scaling; FIG.", "14 depicts a logical flow diagram generally showing one embodiment of a process for responding to a requested decrease in project resources; FIG.", "15 illustrates a logical flow diagram generally showing one embodiment of process for queuing resource requests; FIG.", "16 depicts a logical flow diagram generally showing one embodiment of process for elastically scaling based on index storage size; FIG.", "17 depicts a logical flow diagram generally showing one embodiment of a process for elastically scaling based on indexing performance; FIG.", "18 depicts a logical flow diagram generally showing one embodiment of a process for elastically scaling based on an event time window; FIG.", "19 illustrates a logical flow diagram generally showing one embodiment of a process for changing a number of indexers associated with an index store FIG.", "20 shows a logical flow diagram generally showing one embodiment of a process to recall archived data for re-indexing; FIG.", "21 illustrates a logical flow diagram generally showing one embodiment of a process for transitioning to scaled index stores; FIG.", "22 illustrates a logical flow diagram generally showing one embodiment of an input proxy operation; and FIG.", "23 illustrates a non-exhaustive example of a use case of an embodiment of user-interface controls for managing and processing data volumes.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of the co-pending U.S. Patent Application titled, “ACCESS CONTROL FOR EVENT DATA STORED IN CLOUD-BASED DATA STORES BASED ON INHERITED ROLES,” filed on Oct. 28, 2016 and having Ser.", "No.", "15/336,834 and a continuation of co-pending U.S. Patent Application titled, “ROLE-BASED APPLICATION PROGRAM OPERATIONS ON MACHINE DATA IN A MULTI-TENANT ENVIRONMENT,” filed on Oct. 31, 2016 and having Ser.", "No.", "15/339,884, which is a continuation of U.S. Patent Application titled, “ACCESS CONTROL FOR EVENT DATA STORED IN CLOUD-BASED DATA STORES,” filed on Jan. 26, 2016 and having Ser.", "No.", "15/007,184, Issued Nov. 15, 2016 and having U.S. Pat.", "No.", "9,497,199, which is a continuation of U.S. Patent Application titled, “SEARCHING INDEXED DATA BASED ON USER ROLES,” filed on Jun.", "9, 2015 and having Ser.", "No.", "14/735,120, Issued Dec. 6, 2016 and having U.S. Pat.", "No.", "9,516,029, which is a continuation of U.S. Patent Application titled, “PROJECT RESOURCE ACCESS CONTROL,” filed on Jul.", "31, 2014 and having Ser.", "No.", "14/449,135, Issued Jun.", "9, 2015 and having U.S. Pat.", "No.", "9,055,075, which is a continuation of U.S. Patent Application titled, “ELASTIC SCALING OF DATA VOLUME,” filed on Oct. 31, 2013 and having Ser.", "No.", "14/068,445, Issued Sep. 30, 2014 and having U.S. Pat.", "No.", "8,849,779, which is a continuation of U.S. Patent Application titled, “DATA VOLUME MANAGEMENT,” filed on Oct. 26, 2012 and having Ser.", "No.", "13/662,356, Issued Mar.", "25, 2014 and having U.S. Pat.", "No.", "8,682,930, which is a continuation of U.S. Patent Application titled, “DATA VOLUME MANAGEMENT,” filed on Aug. 10, 2012 and having Ser.", "No.", "13/572,434, Issued Mar.", "25, 2014 and having U.S. Pat.", "No.", "8,682,860, which claims the priority benefit of U.S.", "Provisional Patent Application titled, “DATA VOLUME MANAGEMENT,” filed on Aug. 12, 2011 and having Ser.", "No.", "61/523,063.The subject matter of these related applications is hereby incorporated herein by reference.", "TECHNICAL FIELD The invention is directed to providing services for use by a customer, and more particularly, to providing search services to the customer over a network with a cloud-based system.", "BACKGROUND Many companies install and maintain software for use on a variety of distributed systems that can range from a single computer for a small business to a collection of servers and a plurality of user computer nodes for a large corporation.", "Also, the volume of data processed by a node in a small business can be a magnitude less than the volume of data processed by a node in a large corporation.", "Further, at different times the amount of data to be indexed for searching and the need for speed to search the indexed data can vary.", "Additionally, the type of data processed by large and small business can vary widely, such as sending and receiving messages, creating and storing documents, hosting web sites, database searches, facilitating online transactions, and the like.", "Furthermore, the expense of developing and maintaining software that can handle the type and volume of data processed by a large corporation can be substantially greater than the effort expended to do somewhat the same for a small business.", "Consequently, cloud-based systems that provide software as a service are increasingly popular with different sizes of businesses having different volumes of data and types of data.", "BRIEF DESCRIPTION OF THE DRAWINGS Non-limiting and non-exhaustive embodiments are described with reference to the following drawings.", "In the drawings, like reference numerals refer to like parts throughout the various figures unless otherwise specified.", "For a better understanding, reference will be made to the following Detailed Description, which is to be read in association with the accompanying drawings, wherein: FIG.", "1 illustrates a system environment in which various embodiments may be implemented; FIG.", "2A shows a rack of blade servers that may be included in various embodiments; FIG.", "2B illustrates an embodiment of a blade server that may be included in a rack of blade servers such as that shown in FIG.", "2A; FIG.", "3 shows a mobile device that may be included in various embodiments; FIG.", "4 illustrates a network device that may be included in various embodiments; FIG.", "5 illustrates a system diagram showing an embodiment of a system that may be utilized to implement embodiments of processing, searching and managing data volumes; FIG.", "6 illustrates a system diagram showing an alternative embodiment of a system that may be utilized to implement embodiments of processing, searching and managing data volumes; FIG.", "7 illustrates a logical flow diagram generally showing one embodiment of an overview process for initiating a project that employs embodiments of the system diagrams shown in FIGS.", "5 and/or 6; FIG.", "8 illustrates a logical flow diagram generally showing one embodiment of a process for enabling access to a determined volume of data and restricting access to incoming data that exceeds the determined volume; FIG.", "9 illustrates a logical flow diagram generally showing one embodiment of a process for managing an overflow index store; FIG.", "10 illustrates a logical flow diagram generally showing one embodiment of a process for enabling a project owner to invite another user into the project; FIG.", "11 illustrates a logical flow diagram generally showing one embodiment of an overview process for elastically scaling a project; FIG.", "12 illustrates a logical flow diagram generally showing one embodiment of a process for receiving resource allocation direction from an operator manipulating a user interface control; FIG.", "13 illustrates a logical flow diagram generally showing one embodiment of a process for increasing a project's resources as part of elastic scaling; FIG.", "14 depicts a logical flow diagram generally showing one embodiment of a process for responding to a requested decrease in project resources; FIG.", "15 illustrates a logical flow diagram generally showing one embodiment of process for queuing resource requests; FIG.", "16 depicts a logical flow diagram generally showing one embodiment of process for elastically scaling based on index storage size; FIG.", "17 depicts a logical flow diagram generally showing one embodiment of a process for elastically scaling based on indexing performance; FIG.", "18 depicts a logical flow diagram generally showing one embodiment of a process for elastically scaling based on an event time window; FIG.", "19 illustrates a logical flow diagram generally showing one embodiment of a process for changing a number of indexers associated with an index store FIG.", "20 shows a logical flow diagram generally showing one embodiment of a process to recall archived data for re-indexing; FIG.", "21 illustrates a logical flow diagram generally showing one embodiment of a process for transitioning to scaled index stores; FIG.", "22 illustrates a logical flow diagram generally showing one embodiment of an input proxy operation; and FIG.", "23 illustrates a non-exhaustive example of a use case of an embodiment of user-interface controls for managing and processing data volumes.", "DESCRIPTION OF VARIOUS EMBODIMENTS Throughout the specification and claims, the following terms take the meanings explicitly associated herein, unless the context clearly dictates otherwise.", "The phrase “in one embodiment” as used herein does not necessarily refer to the same embodiment, though it may.", "Furthermore, the phrase “in another embodiment” as used herein does not necessarily refer to a different embodiment, although it may.", "Thus, as described below, various embodiments may be readily combined, without departing from the scope or spirit of the invention.", "In addition, as used herein, the term “or” is an inclusive “or” operator, and is equivalent to the term “and/or,” unless the context clearly dictates otherwise.", "The term “based on” is not exclusive and allows for being based on additional factors not described, unless the context clearly dictates otherwise.", "In addition, throughout the specification, the meaning of “a,” “an,” and “the” include plural references.", "The meaning of “in” includes “in” and “on.” Various embodiments now will be described more fully hereinafter with reference to the accompanying drawings, which form a part hereof, and which show, by way of illustration, specific exemplary embodiments by which the invention may be practiced.", "The embodiments may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the embodiments to those skilled in the art.", "Among other things, the various embodiments may be methods, systems, media or devices.", "Accordingly, the various embodiments may take the form of an entirely hardware embodiment, an entirely software embodiment or an embodiment combining software and hardware aspects.", "The following detailed description is, therefore, not to be taken in a limiting sense.", "For example embodiments, the following terms are also used herein according to the corresponding meaning, unless the context clearly dictates otherwise.", "“Frontend User” as used herein may represent users at the outer cloud-based edge of some of the described embodiments.", "This outer edge may often be described herein as the Web Application Layer, or Cloud layer.", "“Core User” as used herein may represent abstract users that are within the middle of the layers of described embodiments.", "These middle layers may often be described herein as Search Head layers, or Core layers.", "“Apps” as used herein may collectively represent software programs and processes that may implement various features and processing for the various embodiments, some of which are described herein.", "Apps may give users insights into their projects with dashboards, reports, data inputs, and saved searches that may work in the project environment from the moment they are installed.", "Apps may include new views and dashboards that may completely reconfigure the way a project looks.", "Or, they may be as complex as an entirely new program.", "In some embodiments, Apps may also represent index resources.", "“Index”, “Indexer”, “Indexing”, and “Index Storage” as used herein may represent elements of described embodiments that may index and store data and events.", "Indexers may collect, parse, and store data to facilitate fast and accurate information retrieval.", "Index design may incorporate interdisciplinary concepts from linguistics, cognitive psychology, mathematics, informatics, physics, and computer science.", "Also, Indexes may reside in flat files in a data store on a file system.", "Index files may be managed to facilitate flexible searching and fast data retrieval, eventually archiving them according to a configurable schedule.", "During indexing, incoming raw data may be processed to enable fast search and analysis, the results of which may be stored in an index.", "As part of the indexing process, the indexer may add knowledge to the data in various ways, including by: separating a data stream into individual, searchable events; creating or identifying timestamps; extracting fields such as host, source, and source type; performing user-defined actions on the incoming data, such as identifying custom fields, masking sensitive data, writing new or modified keys, applying breaking rules for multi-line events, filtering unwanted events, and routing events to specified indexes or servers, and the like.", "In some embodiments, index store may store data indexed by one or more indexers.", "In at least one embodiment, indexer may include indexer severs.", "“Roles” as used herein may represent definitions of the access permissions and authorizations that enable a Core User to execute various features, Apps, or access data, in the various embodiments.", "Roles may define how a Core User may interact with Apps, Indexes, Indexers, and the like.", "“Dimension” as used herein when describing elastic scaling, may refer to the particular kind of project resources that may be scaled, e.g., index storage, processing performance, time-window, price, network bandwidth, and the like.", "Embodiments may be arranged and configured to define dimensions differently, e.g., one embodiment may be arranged to define an elastic scaling dimension that represents network latency, where another embodiment may be arranged and configured to combine CPU quota, network latency, network bandwidth into a single dimension representing processing performance.", "One of ordinary skill in the art will appreciate that there may be many combinations of resources that may arranged into elastic scaling dimensions.", "Multi-tenant cloud-based data storage volumes may be built to support manual and rule-based elastic scaling.", "Elastic scaling may occur in one or more dimensions, such as scaling of storage, scaling of processing performance, or time windows of received data, and the like.", "Elastic scaling may occur in one or more dimensions singly or in combination.", "If elastic scaling occurs, the appropriate objects, processes, memory, and storage may be scaled to meet the request resource increase or decrease.", "There may be numerous dependent or supporting systems that may need to scale in response to an elastic scaling request.", "For example, a request to elastically scale processing performance may require one or more elements of the system to be scaled in addition to the CPU quota, such as, disk quota, high local cache quota, and the like.", "The following briefly describes embodiments in order to provide a basic understanding of some aspects of the invention.", "This brief description is not intended as an extensive overview.", "It is not intended to identify key or critical elements, or to delineate or otherwise narrow the scope.", "Its purpose is merely to present some concepts in a simplified form as a prelude to the more detailed description that is presented later.", "Briefly stated, various embodiments are directed towards a system and method for a cloud-based front end that may abstract and enable access to the underlying cloud-hosted elements and objects that may be part of a multi-tenant application, such as a search application.", "Search objects may be employed to access indexed objects.", "Also, one or more projects can be elastically scaled for a user to provide resources that may meet the specific needs of each project.", "In some embodiments, at least one project for at least one frontend user may be initialized.", "In at least one embodiment, the frontend user may be enabled to interact with the project through at least one application.", "Each project may have a corresponding index store, which may include one or more indexer servers.", "In at least one embodiment, a data volume limit may be established for the index store.", "The data volume limit may be based on a selection by the frontend user.", "Data provided for the project may be indexed.", "In some embodiments, if an amount of indexed data in the index store is less than the data volume limit, then the indexed data may be stored in the index store.", "In other embodiments, if the amount of indexed data in the index store at least equals the data volume limit, then the indexed data may be stored in an overflow index store.", "In at least one embodiment, the indexed data in the index store may be accessible to the frontend user and the indexed data in the overflow index store may be inaccessible to the frontend user (e.g., the frontend user may be prevented from accessing the data unless the user increases the data volume limit, such as by purchasing additional data storage).", "If the data volume limit is increased, then at least a portion of indexed data in the overflow index store may be provided to the index store, such that the provided indexed data is accessible in the index store to the frontend user.", "In at least one embodiment, the data volume limit may be increased based on another selection by the frontend user.", "In other embodiments, the user may be enabled to elastically scale one or more computing resources associated with a project.", "A resource allocation may be determined for indexing data provided for a project for each of a plurality of resources.", "In at least one embodiment, the resources may include at least one indexer server instance that indexes the provided data, a data store (i.e., storage capacity) that stores the indexed data, an event time window, or the like.", "In at least one embodiment, a request may be provided from a user to scale at least one of the plurality of resources.", "In some embodiments, the user may be enabled to utilize a slider control (or other user interface) to manually adjust one or more computing resources.", "In response to the request, the resource allocation for at least one of the plurality of resources may be adjusted based on the request.", "At least one of the plurality of resources may be changed based on the adjusted resource allocation, which may be employed to subsequently index data provided for the project.", "In some embodiments, at least one type of additional resource may be allocated if the request indicates an increase in the plurality of resources.", "In other embodiments, less of at least one type of resource may be allocated if the change indicates a decrease in the plurality of resources.", "In some embodiments, an increase or decrease in one resource may correspond to an increase or decrease in another resource.", "In at least one embodiment, if a resource is elastically scaled, then a number of indexers may be increased or decreased to accommodate the change in resources.", "In some embodiments, decreasing a number of indexers may include marking an indexer as read-only and increasing a number of indexers may include marking a read-only indexer as read/write and/or adding a new indexer.", "In some embodiments, changing resources may include changing a number of indexer servers employed to index data for the project, changing an amount of storage for the data store to store data for the project, changing an amount of memory employed to process the indexing of data for the project, changing an amount of processors employed to process the indexing of data for the project, or the like.", "Additionally, it should be appreciated that though many embodiments described herein may be cloud-based, embodiments should not be considered so limited.", "One of ordinary skill in the art will recognize that enabling embodiments may be arranged to be partially deployed in cloud-based configurations with some elements in the cloud and some elements separate from cloud based resources.", "Likewise, enabling embodiments may be arranged to be deployed and operate in configurations entirely separate from cloud-based resources.", "Illustrative Operating Environment 1 shows components of an environment in which various embodiments may be practiced.", "Not all of the components may be required to practice the various embodiments, and variations in the arrangement and type of the components may be made without departing from the spirit or scope of the various embodiments.", "In at least one embodiment, cloud network 102 enables one or more network services for a user based on the operation of corresponding arrangements 104 and 106 of virtually any type of networked computing device.", "As shown, the networked computing devices may include server network device 112, host network device 114, enclosure of blade servers 110, enclosure of server computers 116, super computer network device 118, and the like.", "Although not shown, one or more mobile devices may be included in cloud network 102 in one or more arrangements to provide one or more network services to a user.", "Also, these arrangements of networked computing devices may or may not be mutually exclusive of each other.", "Additionally, the user may employ a plurality of virtually any type of wired or wireless networked computing devices to communicate with cloud network 102 and access at least one of the network services enabled by one or more of arrangements 104 and 106.These networked computing devices may include tablet mobile device 122, handheld mobile device 124, wearable mobile device 126, desktop network device 120, and the like.", "Although not shown, in various embodiments, the user may also employ notebook computers, desktop computers, microprocessor-based or programmable consumer electronics, network appliances, mobile telephones, smart telephones, pagers, radio frequency (RF) devices, infrared (IR) devices, Personal Digital Assistants (PDAs), televisions, integrated devices combining at least one of the preceding devices, and the like.", "One embodiment of a mobile device is described in more detail below in conjunction with FIG.", "3.Generally, mobile devices may include virtually any substantially portable networked computing device capable of communicating over a wired, wireless, or some combination of wired and wireless network.", "In various embodiments, network 102 may employ virtually any form of communication technology and topology.", "For example, network 102 can include local area networks Personal Area Networks (PANs), (LANs), Campus Area Networks (CANs), Metropolitan Area Networks (MANs) Wide Area Networks (WANs), direct communication connections, and the like, or any combination thereof.", "On an interconnected set of LANs, including those based on differing architectures and protocols, a router acts as a link between LANs, enabling messages to be sent from one to another.", "In addition, communication links within networks may include virtually any type of link, e.g., twisted wire pair lines, optical fibers, open air lasers or coaxial cable, plain old telephone service (POTS), wave guides, acoustic, full or fractional dedicated digital communication lines including T1, T2, T3, and T4, and/or other carrier and other wired media and wireless media.", "These carrier mechanisms may include E-carriers, Integrated Services Digital Networks (ISDNs), universal serial bus (USB) ports, Firewire ports, Thunderbolt ports, Digital Subscriber Lines (DSLs), wireless links including satellite links, or other communications links known to those skilled in the art.", "Moreover, these communication links may further employ any of a variety of digital signaling technologies, including without limit, for example, DS-0, DS-1, DS-2, DS-3, DS-4, OC-3, OC-12, OC-48, or the like.", "Furthermore, remotely located computing devices could be remotely connected to networks via a modem and a temporary communication link.", "In essence, network 102 may include virtually any communication technology by which information may travel between computing devices.", "Additionally, in the various embodiments, the communicated information may include virtually any kind of information including, but not limited to processor-readable instructions, data structures, program modules, applications, raw data, control data, archived data, video data, voice data, image data, text data, and the like.", "Network 102 may be partially or entirely embodied by one or more wireless networks.", "A wireless network may include any of a variety of wireless sub-networks that may further overlay stand-alone ad-hoc networks, and the like.", "Such sub-networks may include mesh networks, Wireless LAN (WLAN) networks, Wireless Router (WR) mesh, cellular networks, pico networks, PANs, Open Air Laser networks, Microwave networks, and the like.", "Network 102 may further include an autonomous system of intermediate network devices such as terminals, gateways, routers, switches, firewalls, load balancers, and the like, which are coupled to wired and/or wireless communication links.", "These autonomous devices may be operable to move freely and randomly and organize themselves arbitrarily, such that the topology of network 102 may change rapidly.", "Network 102 may further employ a plurality of wired and wireless access technologies, e.g., 2nd (2G), 3rd (3G), 4th (4G), 5th (5G) generation wireless access technologies, and the like, for mobile devices.", "These wired and wireless access technologies may also include Global System for Mobile communication (GSM), General Packet Radio Services (GPRS), Enhanced Data GSM Environment (EDGE), Code Division Multiple Access (CDMA), Wideband Code Division Multiple Access (WCDMA), Long Term Evolution Advanced (LTE), Universal Mobile Telecommunications System (UMTS), Orthogonal frequency-division multiplexing (OFDM), Wideband Code Division Multiple Access (W-CDMA), Code Division Multiple Access 2000 (CDMA2000), Evolution-Data Optimized (EV-DO), High-Speed Downlink Packet Access (HSDPA), IEEE 802.16 Worldwide Interoperability for Microwave Access (WiMax), ultra wide band (UWB), user datagram protocol (UDP), transmission control protocol/Internet protocol (TCP/IP), any portion of the Open Systems Interconnection (OSI) model protocols, Short Message Service (SMS), Multimedia Messaging Service (MMS), Web Access Protocol (WAP), Session Initiation Protocol/Real-time Transport Protocol (SIP/RTP), or any of a variety of other wireless or wired communication protocols.", "In one non-limiting example, network 102 may enable a mobile device to wirelessly access a network service through a combination of several radio network access technologies such as GSM, EDGE, SMS, HSDPA, and the like.", "Enclosure of Blade Servers FIG.", "2A shows one embodiment of an enclosure of blade servers 200, which are also illustrated in FIG.", "1.Enclosure of blade servers 200 may include many more or fewer components than those shown in FIG.", "2A.", "However, the components shown are sufficient to disclose an illustrative embodiment.", "Generally, a blade server is a stripped down server computing device with a modular design optimized to minimize the use of physical space and energy.", "A blade enclosure can include several blade servers and provide each with power, cooling, network interfaces, input/output interfaces, and resource management.", "Although not shown, an enclosure of server computers typically includes several computers that merely require a network connection and a power cord connection to operate.", "Each server computer often includes redundant components for power and interfaces.", "As shown in the figure, enclosure 200 contains power supply 204, and input/output interface 206, rack logic 208, several blade servers 210, 212, 214, and 216, and backplane 202.Power supply 204 provides power to each component and blade server within the enclosure.", "The input/output interface 206 provides internal and external communication for components and blade servers within the enclosure.", "Backplane 208 can enable passive and active communication of power, logic, input signals, and output signals for each blade server.", "Illustrative Blade Server FIG.", "2B illustrates an illustrative embodiment of blade server 250, which may include many more or fewer components than those shown.", "As shown in FIG.", "2A, a plurality of blade servers may be included in one enclosure that shares resources provided by the enclosure to reduce size, power, and cost.", "Blade server 250 includes processor 252 which communicates with memory 256 via bus 254.Blade server 250 also includes input/output interface 290, processor-readable stationary storage device 292, and processor-readable removable storage device 294.Input/output interface 290 can enable blade server 250 to communicate with other blade servers, mobile devices, network devices, and the like.", "Interface 190 may provide wireless and/or wired communication links for blade server.", "Processor-readable stationary storage device 292 may include devices such as an electromagnetic storage device (hard disk), solid state hard disk (SSD), hybrid of both an SSD and a hard disk, and the like.", "Also, processor-readable removable storage device 294 enables processor 252 to read non-transitive storage media for storing and accessing processor-readable instructions, modules, data structures, and other forms of data.", "The non-transitive storage media may include Flash drives, tape media, floppy media, and the like.", "Memory 256 may include Random Access Memory (RAM), Read-Only Memory (ROM), hybrid of RAM and ROM, and the like.", "As shown, memory 256 includes operating system 258 and basic input/output system (BIOS) 260 for enabling the operation of blade server 250.In various embodiments, a general-purpose operating system may be employed such as a version of UNIX, or LINUX™, or a specialized server operating system such as Microsoft's Windows Server™ and Apple Computer's IoS Server™.", "Memory 256 further includes one or more data storage 270, which can be utilized by blade server 250 to store, among other things, applications 280 and/or other data.", "Data stores 270 may include program code, data, algorithms, and the like, for use by processor 252 to execute and perform actions.", "In one embodiment, at least some of data store 270 might also be stored on another component of blade server 250, including, but not limited to, processor-readable removable storage device 294, processor-readable stationary storage device 292, or any other processor-readable storage device (not shown).", "Data storage 270 may include, for example, raw data 272, and indexed data 274.Applications 280 may include processor executable instructions which, when executed by blade server 250, transmit, receive, and/or otherwise process messages, audio, video, and enable communication with other networked computing devices.", "Examples of application programs include database servers, file servers, calendars, transcoders, and so forth.", "Applications 280 may include, for example, cloud search application 282, and indexing application 284.Human interface components (not pictured), may be remotely associated with blade server 250, which can enable remote input to and/or output from blade server 250.For example, information to a display or from a keyboard can be routed through the input/output interface 290 to appropriate peripheral human interface components that are remotely located.", "Examples of peripheral human interface components include, but are not limited to, an audio interface, a display, keypad, pointing device, touch interface, and the like.", "Illustrative Mobile Device FIG.", "3 shows one embodiment of mobile device 300 that may include many more or less components than those shown.", "Mobile device 300 may represent, for example, at least one embodiment of mobile devices shown in FIG.", "1.Mobile device 300 includes processor 302 in communication with memory 304 via bus 328.Mobile device 300 also includes power supply 330, network interface 332, audio interface 356, display 350, keypad 352, illuminator 354, video interface 342, input/output interface 338, haptic interface 364, global positioning systems (GPS) receiver 358, Open air gesture interface 360, temperature interface 362, camera(s) 340, projector 346, pointing device interface 366, processor-readable stationary storage device 334, and processor-readable removable storage device 336.Power supply 330 provides power to mobile device 300.A rechargeable or non-rechargeable battery may be used to provide power.", "The power may also be provided by an external power source, such as an AC adapter or a powered docking cradle that supplements and/or recharges the battery.", "And in one embodiment, although not shown, a gyroscope may be employed within mobile device 300 to measuring and/or maintaining an orientation of mobile device 300.Mobile device 300 may optionally communicate with a base station (not shown), or directly with another computing device.", "Network interface 332 includes circuitry for coupling mobile device 300 to one or more networks, and is constructed for use with one or more communication protocols and technologies including, but not limited to, protocols and technologies that implement any portion of the Open Systems Interconnection (OSI) model for mobile communication (GSM), code division multiple access (CDMA), time division multiple access (TDMA), user datagram protocol (UDP), transmission control protocol/Internet protocol (TCP/IP), Short Message Service (SMS), Multimedia Messaging Service (MMS), general packet radio service (GPRS), WAP, ultra wide band (UWB), IEEE 802.16 Worldwide Interoperability for Microwave Access (WiMax), Session Initiation Protocol/Real-time Transport Protocol (SIP/RTP), or any of a variety of other wireless communication protocols.", "Network interface 332 is sometimes known as a transceiver, transceiving device, or network interface card (NIC).", "Audio interface 356 is arranged to produce and receive audio signals such as the sound of a human voice.", "For example, audio interface 356 may be coupled to a speaker and microphone (not shown) to enable telecommunication with others and/or generate an audio acknowledgement for some action.", "A microphone in audio interface 356 can also be used for input to or control of mobile device 300, e.g., using voice recognition, detecting touch based on sound, and the like.", "Display 350 may be a liquid crystal display (LCD), gas plasma, electronic ink, light emitting diode (LED), Organic LED (OLED) or any other type of light reflective or light transmissive display that can be used with a computing device.", "Display 350 may also include a touch interface 344 arranged to receive input from an object such as a stylus or a digit from a human hand, and may use resistive, capacitive, surface acoustic wave (SAW), infrared, radar, or other technologies to sense touch and/or gestures.", "Projector 346 may be a remote handheld projector or an integrated projector that is capable of projecting an image on a remote wall or any other reflective object such as a remote screen.", "Video interface 342 may be arranged to capture video images, such as a still photo, a video segment, an infrared video, or the like.", "For example, video interface 342 may be coupled to a digital video camera, a web-camera, or the like.", "Video interface 342 may comprise a lens, an image sensor, and other electronics.", "Image sensors may include a complementary metal-oxide-semiconductor (CMOS) integrated circuit, charge-coupled device (CCD), or any other integrated circuit for sensing light.", "Keypad 352 may comprise any input device arranged to receive input from a user.", "For example, keypad 352 may include a push button numeric dial, or a keyboard.", "Keypad 352 may also include command buttons that are associated with selecting and sending images.", "Illuminator 354 may provide a status indication and/or provide light.", "Illuminator 354 may remain active for specific periods of time or in response to events.", "For example, when illuminator 354 is active, it may backlight the buttons on keypad 352 and stay on while the mobile device is powered.", "Also, illuminator 354 may backlight these buttons in various patterns when particular actions are performed, such as dialing another mobile device.", "Illuminator 354 may also cause light sources positioned within a transparent or translucent case of the mobile device to illuminate in response to actions.", "Mobile device 300 also comprises input/output interface 338 for communicating with external peripheral devices or other computing devices such as other mobile devices and network devices.", "The peripheral devices may include an audio headset, display screen glasses, remote speaker system, remote speaker and microphone system, and the like.", "Input/output interface 338 can utilize one or more technologies, such as Universal Serial Bus (USB), Infrared, WiFi, WiMax, Bluetooth™, and the like.", "Haptic interface 364 is arranged to provide tactile feedback to a user of the mobile device.", "For example, the haptic interface 364 may be employed to vibrate mobile device 300 in a particular way when another user of a computing device is calling.", "Temperature interface 362 may be used to provide a temperature measurement input and/or a temperature changing output to a user of mobile device 300.Open air gesture interface 360 may sense physical gestures of a user of mobile device 300, for example, by using single or stereo video cameras, radar, a gyroscopic sensor inside a device held or worn by the user, or the like.", "Camera 340 may be used to track physical eye movements of a user of mobile device 300.GPS transceiver 358 can determine the physical coordinates of mobile device 300 on the surface of the Earth, which typically outputs a location as latitude and longitude values.", "GPS transceiver 358 can also employ other geo-positioning mechanisms, including, but not limited to, triangulation, assisted GPS (AGPS), Enhanced Observed Time Difference (E-OTD), Cell Identifier (CI), Service Area Identifier (SAI), Enhanced Timing Advance (ETA), Base Station Subsystem (BSS), or the like, to further determine the physical location of mobile device 300 on the surface of the Earth.", "It is understood that under different conditions, GPS transceiver 358 can determine a physical location for mobile device 300.In at least one embodiment, however, mobile device 300 may, through other components, provide other information that may be employed to determine a physical location of the device, including for example, a Media Access Control (MAC) address, IP address, and the like.", "Human interface components can be peripheral devices that are physically separate from mobile device 300, allowing for remote input and/or output to mobile device 300.For example, information routed as described here through human interface components such as display 350 or keyboard 352 can instead be routed through network interface 332 to appropriate human interface components located remotely.", "Examples of human interface peripheral components that may be remote include, but are not limited to, audio devices, pointing devices, keypads, displays, cameras, projectors, and the like.", "These peripheral components may communicate over a Pico Network such as Bluetooth™, Zigbee™ and the like.", "One non-limiting example of a mobile device with such peripheral human interface components is a wearable computing device, which might include a remote pico projector along with one or more cameras that remotely communicate with a separately located mobile device to sense a user's gestures toward portions of an image projected by the pico projector onto a reflected surface such as a wall or the user's hand.", "A mobile device may include a browser application that is configured to receive and to send web pages, web-based messages, graphics, text, multimedia, and the like.", "The mobile device's browser application may employ virtually any programming language, including a wireless application protocol messages (WAP), and the like.", "In at least one embodiment, the browser application is enabled to employ Handheld Device Markup Language (HDML), Wireless Markup Language (WML), WMLScript, JavaScript, Standard Generalized Markup Language (SGML), HyperText Markup Language (HTML), eXtensible Markup Language (XML), HTML5, and the like.", "Memory 304 may include Random Access Memory (RAM), Read-Only Memory (ROM), and/or other types of memory.", "Memory 304 illustrates an example of computer-readable storage media (devices) for storage of information such as computer-readable instructions, data structures, program modules or other data.", "Memory 304 stores a basic input/output system (BIOS) 308 for controlling low-level operation of mobile device 300.The memory also stores an operating system 306 for controlling the operation of mobile device 300.It will be appreciated that this component may include a general-purpose operating system such as a version of UNIX, or LINUX™, or a specialized mobile computer communication operating system such as Windows Mobile™, or the Symbian® operating system.", "The operating system may include, or interface with a Java virtual machine module that enables control of hardware components and/or operating system operations via Java application programs.", "Memory 304 further includes one or more data storage 310, which can be utilized by mobile device 300 to store, among other things, applications 320 and/or other data.", "For example, data storage 310 may also be employed to store information that describes various capabilities of mobile device 300.The information may then be provided to another device based on any of a variety of events, including being sent as part of a header during a communication, sent upon request, or the like.", "Data storage 310 may also be employed to store social networking information including address books, buddy lists, aliases, user profile information, or the like.", "Data storage 310 may further include program code, data, algorithms, and the like, for use by a processor, such as processor 302 to execute and perform actions.", "In one embodiment, at least some of data storage 310 might also be stored on another component of mobile device 300, including, but not limited to, non-transitory processor-readable removable storage device 336, processor-readable stationary storage device 334, or even external to the mobile device.", "Data storage 310 may include, for example, raw data 312, and index data 314.Applications 320 may include computer executable instructions which, when executed by mobile device 300, transmit, receive, and/or otherwise process instructions and data.", "Applications 320 may include, for example, Cloud Search application 322, and Indexing Application 324.Other examples of application programs include calendars, search programs, email client applications, IM applications, SMS applications, Voice Over Internet Protocol (VOIP) applications, contact managers, task managers, transcoders, database programs, word processing programs, security applications, spreadsheet programs, games, search programs, and so forth.", "Illustrative Network Device FIG.", "4 shows one embodiment of network device 400 that may be included in a system implementing the invention.", "Network device 400 may include many more or less components than those shown in FIG.", "4.However, the components shown are sufficient to disclose an illustrative embodiment for practicing the present invention.", "Network device 400 may represent, for example, one embodiment of at least one of network device 112, 114, or 120 of FIG.", "1.As shown in the figure, network device 400 includes a processor 402 in communication with a memory 404 via a bus 428.Network device 400 also includes a power supply 430, network interface 432, audio interface 456, display 450, keyboard 452, input/output interface 438, processor-readable stationary storage device 434, and processor-readable removable storage device 436.Power supply 430 provides power to network device 400.Network interface 432 includes circuitry for coupling network device 400 to one or more networks, and is constructed for use with one or more communication protocols and technologies including, but not limited to, protocols and technologies that implement any portion of the Open Systems Interconnection model (OSI model), global system for mobile communication (GSM), code division multiple access (CDMA), time division multiple access (TDMA), user datagram protocol (UDP), transmission control protocol/Internet protocol (TCP/IP), Short Message Service (SMS), Multimedia Messaging Service (MMS), general packet radio service (GPRS), WAP, ultra wide band (UWB), IEEE 802.16 Worldwide Interoperability for Microwave Access (WiMax), Session Initiation Protocol/Real-time Transport Protocol (SIP/RTP), or any of a variety of other wired and wireless communication protocols.", "Network interface 432 is sometimes known as a transceiver, transceiving device, or network interface card (NIC).", "Network device 400 may optionally communicate with a base station (not shown), or directly with another computing device.", "Audio interface 456 is arranged to produce and receive audio signals such as the sound of a human voice.", "For example, audio interface 456 may be coupled to a speaker and microphone (not shown) to enable telecommunication with others and/or generate an audio acknowledgement for some action.", "A microphone in audio interface 456 can also be used for input to or control of network device 400, for example, using voice recognition.", "Display 450 may be a liquid crystal display (LCD), gas plasma, electronic ink, light emitting diode (LED), Organic LED (OLED) or any other type of light reflective or light transmissive display that can be used with a computing device.", "Display 450 may be a handheld projector or pico projector capable of projecting an image on a wall or other object.", "Network device 400 also may also comprise input/output interface 438 for communicating with external devices not shown in FIG.", "4.Input/output interface 438 can utilize one or more wired or wireless communication technologies, such as USB™, Firewire™, WiFi, WiMax, Thunderbolt™, Infrared, Bluetooth™, Zigbee™, serial port, parallel port, and the like.", "Human interface components can be physically separate from network device 400, allowing for remote input and/or output to network device 400.For example, information routed as described here through human interface components such as display 450 or keyboard 452 can instead be routed through the network interface 432 to appropriate human interface components located elsewhere on the network.", "Human interface components include any component that allows the computer to take input from, or send output to, a human user of a computer.", "Memory 404 may include Random Access Memory (RAM), Read-Only Memory (ROM), and/or other types of memory.", "Memory 404 illustrates an example of computer-readable storage media (devices) for storage of information such as computer-readable instructions, data structures, program modules or other data.", "Memory 404 stores a basic input/output system (BIOS) 408 for controlling low-level operation of network device 400.The memory also stores an operating system 406 for controlling the operation of network device 400.It will be appreciated that this component may include a general-purpose operating system such as a version of UNIX, or LINUX™, or a specialized operating system such as Microsoft Corporation's Windows® operating system, or the Apple Corporation's iOS® operating system.", "The operating system may include, or interface with a Java virtual machine module that enables control of hardware components and/or operating system operations via Java application programs.", "Memory 404 further includes one or more data storage 410, which can be utilized by network device 400 to store, among other things, applications 420 and/or other data.", "For example, data storage 410 may also be employed to store information that describes various capabilities of network device 400.The information may then be provided to another device based on any of a variety of events, including being sent as part of a header during a communication, sent upon request, or the like.", "Data storage 410 may also be employed to store social networking information including address books, buddy lists, aliases, user profile information, or the like.", "Data stores 410 may further include program code, data, algorithms, and the like, for use by a processor, such as processor 402 to execute and perform actions.", "In one embodiment, at least some of data store 410 might also be stored on another component of network device 400, including, but not limited to, non-transitory media inside processor-readable removable storage device 436, processor-readable stationary storage device 434, or any other computer-readable storage device within network device 400, or even external to network device 400.Data storage 410 may include, for example, raw data 412, and indexed data 414.Applications 420 may include computer executable instructions which, when executed by network device 400, transmit, receive, and/or otherwise process messages (e.g., SMS, Multimedia Messaging Service (MMS), Instant Message (IM), email, and/or other messages), audio, video, and enable telecommunication with another user of another mobile device.", "Other examples of application programs include calendars, search programs, email client applications, IM applications, SMS applications, Voice Over Internet Protocol (VOIP) applications, contact managers, task managers, transcoders, database programs, word processing programs, security applications, spreadsheet programs, games, search programs, and so forth.", "Applications 420 may include, for example, cloud search application 422, and indexing application 424.Illustrative System Diagram FIG.", "5 depicts an embodiment where the top layer of the figure, indicated as Web Application Layer 502, may represent a cloud-based front end that may abstract and enable access to the underlying cloud-hosted elements and objects that may be part of a multi-tenant application that may comprise Core User (e.g., Core User 518 and Core User 520), Roles (e.g., Role 522 and Role 524), and Apps (e.g., App 526 and App 528), indicated as the Search Head 504.The objects in the Search Head 504 layer may be employed to access the Index objects located in the Indexers 506 layer of FIG.", "5.The two projects, Project 1 (i.e., project 508) and Project 2 (i.e., project 510) in the Web Application Layer 502 may be examples of projects that have been elastically scaled to provide resources that may meet the specific needs of each project.", "As depicted, Project 1 may require twice as much performance and Project 2, the figure represents this with the additional Apps (i.e., App 526 and App 528) in the Search Head 504 layer, and the two index stores (i.e., index 530 and index 532) in the Indexer 506 layer.", "Also, the embodiment in FIG.", "5, demonstrates that a Frontend User may have access to one or more Projects.", "For example, frontend user 512 may have access to project 508, Frontend User 516 may have access to project 510, and Frontend User 514 may have access to both project 508 and project 510.An embodiment may enable the Search Head 504 layer of a Project (e.g., project 508) to create unique Core Users in the Search Head 504 layer that may be linked to Frontend Users from the Web Application Layer 502.For example, Core User 518 may be linked to Frontend User 512 and Core User 520 may be linked to Frontend User 514.A Role of the Core User that may be linked to the Frontend User may enable access control for the Apps and other objects within the Search Head layer.", "For example, Role 522 of Core User 518 may enable Frontend User 512 to access control for App 526 and App 528.Similarly, Role 524 of Core User 520 may enable Frontend User 514 to access control for App 526 and App 528.The Role may determine the specific features that are made available to a Core User, and a Frontend User may have its access within a Project controlled by the Role of the Core User it is linked with.", "In other words, as depicted by FIG.", "5, the Roles may be thought of as providing pathways for the Frontend User to reach the Apps.", "In some embodiments, the Roles may also control access to indexers.", "For example, Role 522 may control access of Core User 518 to Apps 526 and/or 528 as well as index 530 and/or 532.FIG.", "6, depicts an embodiment where Frontend User 1 (i.e., Frontend User 612) may be the owner of two projects, Project 1 (i.e., Project 608) and Project 2 (i.e., Project 610).", "As shown in the figure, Frontend User 2 (i.e., Frontend User 614) may not be an owner of a project.", "But, Frontend User 2 illustrates how a Frontend User may be invited by a project owner, represented in this embodiment by the depicted Frontend User 1.In at least one embodiment, Frontend User 612 and/or Frontend User 614 may be an embodiment of a Frontend User from FIG.", "5.In some embodiments, Project 608 and Project 610 may be embodiments of Project 508 and Project 510 of FIG.", "5, respectively.", "Web Application Layer 602, Search Head 604, and Indexers 606 may be embodiments of Web Application Layer 502, Search Head 504, and Indexers 506 of FIG.", "5, respectively.", "Similar to the embodiment depicted in FIG.", "5, this embodiment may enable unique Core Users to be created and linked to Frontend Users.", "For example, Core User 618 and Core User 620 may be linked to Frontend User 612 and Core User 622 may be linked to Frontend User 614.For each unique Core User, a Role may be created to define the features that may be accessed by the Frontend User.", "For example, Role 624 of Core User 618 may define the features that may be accessed by Frontend User 612 (e.g., App 626).", "The embodiment depicted in FIG.", "6, may also enable Indexes (e.g., Index 632), Ports (e.g., Port 634), and associated storage to be located separately from the Search Head/Core layer objects.", "Also, embodiments may locate Indexes, and Ports across more than one computing device e.g., computing device 628 and computing device 630), including, network computing devices, blade servers, individual blade computers, cloud-based compute instances, virtual machines, and the like.", "Further, Indexes that may be associated with different Projects may be co-located on the same computing device, such as, network computing devices, blade servers, individual blade computers, cloud-based compute instances, virtual machines, and the like.", "General Operation of Data Volume Management The operation of certain aspects of the invention will now be described with respect to FIGS.", "7-10.FIG.", "7 illustrates a logical flow diagram generally showing one embodiment of an overview process for initiating a project that employs embodiments of the system diagrams shown in FIGS.", "5 and/or 6.In some embodiments, process 700 of FIG.", "7 may be implemented by and/or executed on a single network device, such as network device 400 of FIG.", "4.In other embodiments, process 700 or portions of process 700 of FIG.", "7 may be implemented by and/or executed on a plurality of network devices, such as network device 400 of FIG.", "4.In yet other embodiments, process 700 or portions of process 700 of FIG.", "7 may be implemented by and/or executed on one or more blade servers, such as blade server 250 of FIG.", "2B.", "Process 700 begins, after a start block, at block 702 where at least one project may be initialized for at least one Frontend User.", "In some embodiments, Roles, Apps, Indexes, or the like may be created and/or configured for each unique project.", "In some embodiments, blocks 704, 706, 708, 710, and 712 may be performed in an order other than illustrated in FIG.", "7.Processing continues at block 704, where one or more Apps may be created and/or associated with the project.", "In some embodiments, the associated Apps may be identified by the Frontend User.", "Process 700 continues at block 706, where at least one Role may be determined for the project.", "In some embodiments, an operator and/or the Frontend User may generate and/or modify the access permissions associated with the Role.", "In at least one embodiment, at least one Role for each frontend user may be determined that may establish permissions for interacting with the at least one project and the at least one application for each Frontend User.", "In at least one embodiment, the Roles may configure access control for a Frontend User to the Apps and/or the indexers.", "For example, in some embodiments, Roles may enable one Frontend User to access one App (and/or indexer), but not another App (and/or indexer).", "In some embodiments, a plurality of Roles may be determined for each Core User.", "Process 700 proceeds to block 708, where a Core User on the project may be created for the Frontend User.", "In at least one embodiment, creating a Core User may include determining a Core User that corresponds to a frontend user and a project, wherein the Core User enables the Frontend User to interact with the project.", "In some embodiments, the Core User may inherit one or more corresponding Roles determined at block 706.Process 700 continues next at block 710, where the Frontend User may be linked with the Core User and the Role.", "Process 700 proceeds to block 712, where an available index store may be established for the project.", "In at least one embodiment, an available index store may refer to an index store that is accessible by the Frontend User.", "In some embodiments, the Frontend User may be enabled to search the available index store.", "In at least one embodiment, the available index store may include one or more indexer instances.", "In some embodiments, the indexers may be configured based on the Roles.", "As described above, access to the index store (and/or the Apps) may be controlled by the Roles.", "In some other embodiments, a port may be assigned to each individual index.", "Continuing to block 714, the index store may be dynamically scaled, which is described in more detail below in conjunction with FIG.", "8.Briefly, however, the index store may be dynamically scaled based on the Frontend User account.", "For example, if the index store exceeds a pre-purchased data volume, then incoming data may continue to be index, but the Frontend User may not be able to access the incoming data until the Frontend User pays for an increase in the data volume.", "In some embodiments, the Frontend User may be enabled to select when and/or how dynamic scaling may be employed.", "For example, in some embodiments, the Frontend User may determine that if an index size limit is reached, at least one of the following may occur, including: automatically deleting additional data provided for the project beyond the size limit, the indexers may automatically stop indexing data, automatically increasing the storage size of data supported for a project, or the like.", "After block 714, process 700 may return control to a calling process.", "FIG.", "8 illustrates a logical flow diagram generally showing one embodiment of a process for enabling access to a determined volume of data and restricting access to incoming data that exceeds the determined volume.", "In some embodiments, process 800 of FIG.", "8 may be implemented by and/or executed on a single network device, such as network device 400 of FIG.", "4.In other embodiments, process 800 or portions of process 800 of FIG.", "8 may be implemented by and/or executed on a plurality of network devices, such as network device 400 of FIG.", "4.In yet other embodiments, process 800 or portions of process 800 of FIG.", "8 may be implemented by and/or executed on one or more blade servers, such as blade server 250 of FIG.", "2B.", "Process 800 begins, after a start block, at block 802, data may be provided.", "In some embodiments, the data may be incoming data for a given project.", "In other embodiments, the data may be archived data for a given project that may be recovered.", "Process 800 continues at block 804, where the data may be indexed.", "Process 800 proceeds to decision block 806, where a determination may be made whether a data volume limit is exceeded by the indexed data.", "In one embodiment, each project may include a data volume limit.", "In another embodiment, each frontend user (or group of frontend users) may be associated with a data volume limit.", "In at least one embodiment, the total stored data plus the indexed data may be compared to a maximum allowable data volume limit.", "In some embodiment, the data volume limit may be based on an amount of storage space purchased by a user (e.g., a Frontend User).", "If the data volume limit is exceeded, then process 800 may flow to block 810; otherwise, process 800 may flow to block 808.At block 808, the indexed data may be stored in an available index store.", "In some embodiments, an available index store may refer to an index store that is accessible to the user.", "Process 800 may proceed to block 818.If, at decision block 806, the data volume limit is exceeded, then process 800 may flow from decision block 806 to block 810.At block 810, the indexed data may be stored in an overflow index store.", "In some embodiments, the overflow index store may be unavailable to the user.", "The overflow index store allows continued indexing of a user's data even if the amount of data has exceeded a purchased maximum data volume.", "However, the user may not have access to the data in the overflow index store, unless the user purchases additional data volume.", "In at least one embodiment, the overflow index store may be a FIFO buffer.", "The data in the overflow index store may remain in the overflow index store until a user purchases additional data volume and/or the data is removed (e.g., deleted/archived) after a predetermined amount of time.", "Some embodiments for removing data from the overflow index store are described in more detail below in conjunction with FIG.", "9.In any event, process 800 next flows to decision block 812, where a determination may be made whether access to data in the overflow index store is enabled.", "In some embodiments, access may be enabled if the user increases the data storage volume, such as by purchasing additional data storage.", "In at least one embodiment, the data storage volume may be elastically scaled as described in more detail below in conjunction with FIGS.", "11-23.If access to the overflow index store is enabled, process 800 may flow to block 814; otherwise, process 800 may flow to block 818.At block 814, an amount of data in the overflow index store to make available may be determined.", "In some embodiments, the amount of data may be equal to or less than an increase in data storage volume.", "For example, if the user purchases an extra 2 GB of data storage, then it may be determined that up to 2 GB of data from the overflow index store may be made available.", "In some embodiments, the determined amount of data may be pulled from the overflow index store based on a FIFO (first in first out) buffer architecture of the overflow index store.", "In some embodiment, the indexed data that exceeds the data volume limit of the available index store is automatically deleted based on at least one of a first in first out operation of the overflow index store or any indexed data that exceeds the data volume limit.", "Process 800 proceeds to block 816, where the determined amount of data may be provided to the available index store.", "In at least one embodiment, determining an amount of indexed data to copy from the overflow index store to the index store based on at least an increase to the data volume limit.", "In another embodiment, providing the data from the overflow index store to the available index store may include modifying an index store flag; copying the data from the overflow index store to the available index store, or the like.", "In some embodiments, at least a portion of the indexed data in the overflow index store may be copied to archival storage.", "For example, the indexed data provided from the overflow index store to the available index store may also be provided to and/or copied to archival storage.", "Process 800 continues next at block 818, where the user may be enabled to access the available index store.", "In at least one embodiment, the user may be enabled to perform searches for data in the available index store.", "After block 800, process 800 may return control to a calling process.", "FIG.", "9 illustrates a logical flow diagram generally showing one embodiment of a process for managing an overflow index store.", "In some embodiments, process 900 of FIG.", "9 may be implemented by and/or executed on a single network device, such as network device 400 of FIG.", "4.In other embodiments, process 900 or portions of process 900 of FIG.", "9 may be implemented by and/or executed on a plurality of network devices, such as network device 400 of FIG.", "4.In yet other embodiments, process 900 or portions of process 900 of FIG.", "9 may be implemented by and/or executed on one or more blade servers, such as blade server 250 of FIG.", "2B.", "Process 900 begins, after a start block, at decision block 902, where a determination may be made whether to remove data from the overflow index store.", "In some embodiments, data may be removed from the overflow index store when it is moved to the available index store.", "In other embodiments, data may be removed from the overflow index store after a predetermined amount of time.", "In yet other embodiments, data may be removed from the overflow index store if the amount of data in overflow index store exceeds a maximum overflow index store volume.", "If data is removed from the overflow index store, then process 900 may flow to decision block 904; otherwise, process 900 may return control to a calling process.", "At decision block 904, a determination may be made whether the removed data is moved to archival storage.", "In some embodiments, this determination may be based on user preferences, settings, rules (e.g., Roles), or the like.", "For example, an account for the user may indicate that the data removed from the overflow index store may be deleted without archiving the data.", "In other embodiments, the determination may be based on whether the data was added to the available index store at block 816 of FIG.", "8.In one such embodiment, if the data was added to the available index store, then the data may be moved to archival storage.", "If the data is moved to archival storage, then process 900 may flow to block 906; otherwise, process 900 may flow to block 908.At block 906, data may be moved from the overflow index store to archival storage.", "In one embodiment, data may be moved to the archival storage based on a FIFO buffer architecture of the overflow index store.", "In some embodiments, an amount of data to be moved to the archival storage may be based on the FIFO buffer.", "In other embodiments, the amount of data to be moved may be based on an amount of data added to the available index store at block 816 of FIG.", "8.Process 900 proceeds to block 908, where data may be deleted from the overflow index store.", "In one embodiment, data may be deleted based on a FIFO buffer architecture of the overflow index store.", "In some embodiments, an amount of data to be deleted may be based on the FIFO buffer.", "In other embodiments, the amount of data to be deleted may be based on an amount of data added to the available index store at block 816 of FIG.", "8.After block 908, process 900 may return control to a calling process.", "FIG.", "10, illustrates a logical flow diagram generally showing one embodiment of a process for enabling a project owner to invite another user into the project.", "In some embodiments, process 1000 of FIG.", "10 may be implemented by and/or executed on a single network device, such as network device 400 of FIG.", "4.In other embodiments, process 1000 or portions of process 1000 of FIG.", "10 may be implemented by and/or executed on a plurality of network devices, such as network device 400 of FIG.", "4.In yet other embodiments, process 1000 or portions of process 1000 of FIG.", "10 may be implemented by and/or executed on one or more blade servers, such as blade server 250 of FIG.", "2B.", "Process 1000 begins, after a start block, at block 1002, where a project owner may be enabled to send an invitation to an invited user.", "Also, any project user, or administrative user having the authority to invite users to a particular project may send invitations.", "Further, though not depicted in FIG.", "10, administrators, or other authorized users may define negative or positive restrictions on the users that may be invited to project.", "Restrictions may be defined for many purposes including, project security, privacy, licensing, and the like.", "Restrictions may be based on individual users as well as groups, lists, patterns, and the like.", "Process 1000 proceeds to decision block 1004, where a determination may be made whether a user accepted the invitation.", "In at least one embodiment, an invited user may have the choice to accept the invitation.", "However, some embodiments may automatically join invited users to a project without giving them the option to decline the invitation.", "If an invited user declines or ignores an invitation, then process 1000 may return to the calling process; otherwise, process 1000 may flow to decision block 1006.In some embodiments the sender of the invitation may receive notice that the invitation has been declined or ignored.", "At decision block 1006, a determination may be made whether the invited user has a Frontend User account.", "If the invited user has an active Frontend User account, then process 1000 may flow to block 1010; otherwise, process 1000 may flow to block 1008.At block 1008, the invited user may create a Frontend User account.", "Processing continues at block 1010, where a new Core User on a project may be creased.", "Proceeding to block 1012, a corresponding new Role for the new Core User may also be determined.", "In some embodiments, one or more new Roles may be created for the new Core User.", "In other embodiments, the new Core User may inherit one or more Roles from the user who initiated in invitation.", "Process 1000 proceeds to block 1014, where the invited Frontend User may be linked with the new Core User and the new Role.", "After block 1014, process 1000 may return control to a calling process.", "General Operation of Elastic Scaling of Data Volumes The operation of certain aspects of the invention will now be described with respect to FIGS.", "11-22.FIG.", "11 illustrates a logical flow diagram generally showing one embodiment of an overview process for elastically scaling a project.", "In some embodiments, process 1100 of FIG.", "11 may be implemented by and/or executed on a single network device, such as network device 400 of FIG.", "4.In other embodiments, process 1100 or portions of process 1100 of FIG.", "11 may be implemented by and/or executed on a plurality of network devices, such as network device 400 of FIG.", "4.In yet other embodiments, process 1100 or portions of process 1100 of FIG.", "11 may be implemented by and/or executed on one or more blade servers, such as blade server 250 of FIG.", "2B.", "Process 1100 begins, after a start block, at block 1102, where resources allocated for use by the Project may be determined to be sub-optimal.", "Such a determination may be made by many methods, including, rule-based systems, or manual systems.", "Embodiments may apply various rule-based systems that may enable determining that a project is operating with suboptimal resources.", "Such rule-based systems may include, detecting if a performance metric threshold has been exceeded, triggering resource allocations based on schedule, triggering resource allocations based on pattern prediction that may indicate a potential change in utilization requirements, and the like.", "In addition, an operator may determine by observation that resources are suboptimal.", "Process 1100 next proceeds to block 1104, where, the optimal level of project resources may be determined.", "In some embodiments, optimal resources may be static or dynamic.", "In at least one embodiment, optimal resources may be automatically determined by rule-based systems, predictive computing techniques, or the like.", "In another embodiment, optimal resources may be manually determined by an operator.", "The specific allocation of resources may be determined in part by the characteristics of the project, or they may be determined by factors external to project.", "For example, a project that requires a very large dataset may have an optimal resource allocation that emphasizes increased data storage volume over processor performance.", "Process 1100 continues at block 1106, where the project resources may be scaled to support the determined optimal level.", "Additional non-limiting embodiments of elastic scaling of project resources are described below.", "After block 1106, process 1100 may return control to a calling process.", "FIG.", "12 illustrates a logical flow diagram generally showing one embodiment of a process for receiving resource allocation direction from an operator manipulating a user interface control.", "In some embodiments, process 1200 of FIG.", "12 may be implemented by and/or executed on a single network device, such as network device 400 of FIG.", "4.In other embodiments, process 1200 or portions of process 1200 of FIG.", "12 may be implemented by and/or executed on a plurality of network devices, such as network device 400 of FIG.", "4.In yet other embodiments, process 1200 or portions of process 1200 of FIG.", "12 may be implemented by and/or executed on one or more blade servers, such as blade server 250 of FIG.", "2B.", "The user interface control may have a user interface that represents a slider, dial, selection lists, radio buttons, check boxes, and the like.", "Embodiments may be arranged to map various elastic scaling dimensions to a control.", "For example, a control may represent processing performance, index storage, time-window of received data, and the like.", "An embodiment of a use case of a slider user interface is described in more detail below in conjunction with FIG.", "23.Process 1200 begins, after a start block, at block 1202, where a control change (delta) may be received.", "In at least one embodiment, an operator may change, or manipulate the control to provide the delta.", "In some embodiments, a signal, message, or notification from the control may be received indicating that a change in the control may have occurred (i.e., the delta).", "Process 1200 proceeds next to decision block 1204, where a determination may be made whether the delta is greater than zero.", "In at least one embodiment, a delta greater than zero may indicate a request to increase resources for the instant project.", "If the delta is greater than zero, then process 1200 may flow to block 1206; otherwise, process 1200 may flow to decision block 1208.At block 1206, the resources for the project may be increased.", "One embodiment of a process for increasing resources for a project is described in more detail below in conjunction with FIG.", "13.After block 1206, process 1200 may return control to a calling process.", "If, at decision block 1204, the delta is not greater than zero, then processing may flow from decision block 1204 to decision block 1208.At decision block 1208 a determination may be made whether the delta is less than zero.", "In at least one embodiment, a delta less than zero may indicate a request to decrease resources for the instant project.", "If the delta is less than zero, then process 1200 may flow to block 1210; otherwise, process 1200 may return control to a calling process.", "At block 1210, the resources for the project may be decreased.", "One embodiment of a process for decreasing resources for a project is described in more detail below in conjunction with FIG.", "10.Note, the concept of increasing or decreasing resources as used herein is generalized to refer to increasing or decreasing project resources in a defined and configured “dimension.” Thus, it is important to recognize that increasing project resources in a particular defined dimension may actually require some computing resources to be increased while other may be decreased.", "For example, if for an embodiment, a single project resource elastic scaling dimension has been arranged such the increasing a slider (delta>zero) means to emphasize storage and de-emphasize processing speed, then the effect may be to increase storage and reduce the CPU quota.", "Whereas, staying with this example, decreasing the slider (delta<zero) may mean to de-emphasize storage and emphasize processing speed, then the effect may be to de-increase storage and increase the CPU quota.", "In some embodiments there may be a separate slider or control for many of the computing and performance attributes that make up project resources.", "One of ordinary skill in the art will appreciate that sliders and controls may be arranged and configured in many ways to provide operators with a user-interface for controlling the elastic scaling of project resources.", "Embodiments may range from single controls that effect many elements of the computing process with a single action, to many fine grain controls that may be designed to elastically scale individual computing performance attributes.", "For example, an embodiment enabling fine grain control may have separate controls to adjust CPU quota, RAM use, disk access, network bandwidth, process priority, and the like.", "Similarly, on the other end of the spectrum, an embodiment may implement a single high level control in the aggregate that may be arranged to hide and abstract the separate adjustments to CPU quota, RAM use, disk access, network bandwidth, process priority, and the like.", "In the case of high-level controls the operator may not be required to have knowledge that a single change in the high level control may affect many of the project's resource components.", "Next, process 1200 may return control to a calling process.", "FIG.", "13 illustrates a logical flow diagram generally showing one embodiment of a process for increasing a project's resources as part of elastic scaling.", "In some embodiments, process 1300 of FIG.", "13 may be implemented by and/or executed on a single network device, such as network device 400 of FIG.", "4.In other embodiments, process 1300 or portions of process 1300 of FIG.", "13 may be implemented by and/or executed on a plurality of network devices, such as network device 400 of FIG.", "4.In yet other embodiments, process 1300 or portions of process 1300 of FIG.", "13 may be implemented by and/or executed on one or more blade servers, such as blade server 250 of FIG.", "2B.", "Process 1300 begins, after a start block, at block 1302, where particular computing resources that correspond to the requested increase in resources may be determined.", "As discussed above a requested increase of resources may be a simple request to increase a single component of the computing system, such as CPU quota, or it may represent an increase in an elastic scaling dimension that may require the adjustment and reallocation of more than one component in the computing system, such as, CPU quota, RAM quota, network bandwidth quota, and the like.", "In some embodiments, an increase of one resource may result in a decrease of another resource.", "Process 1300 next proceeds to block 1304, where the impact that the requested resources may have on the project, other projects, and/or the system in general may be determined.", "In some embodiments, the impact of the requested resources may be static or dynamic.", "In at least one embodiment, the impact may be automatically determined by rule-based systems, predictive computing techniques, or the like.", "In another embodiment, the impact may be manually determined by an operator.", "Embodiments may be arranged to define rules and thresholds that may set limits on the resources that may be allocated to individual projects.", "Also, rules may be arranged to determine minimum resources that may be made available for other projects in the system.", "One of ordinary skill in the art will appreciate that there may be many factors that may be available for analysis when determining if the requested increase of resources may cause unacceptable impact on the project, projects, and/or the system in general.", "For example, a request to increase index storage size to a very large size may cause such a large data set to be created that the project may not have CPU quota, or RAM quota to effectively process the large dataset.", "How a condition like this is handled depends on how the embodiment is arranged and configured.", "In some cases, such an increase in project resources may be aborted because it is out of bounds.", "In other cases, referring to the example above, an embodiment may determine the necessary CPU quota and RAM quota that may be necessary to keep up with the projected increased index storage size.", "After the necessary resources for the requested increase of resources has been determined process 1300 continues at decision block 1306, where a determination may be made whether there is global headspace available for the requested increase of resources.", "In at least one embodiment, this determination may be made by testing the amount of global headspace available.", "This test may take into account all of the resources available and provisioned for the operator or process that is requesting the increase of resources for the project.", "For example, an embodiment may require users to supply a pre-authorization when requested resources would increase a user's total usage of system resources beyond a certain level.", "Or, an embodiment may be configured to require an administrative user to authorize any resource increase request that may increase total resource use beyond a configured level.", "In any event, an embodiment may test whether the global conditions may be able to absorb the requested increase in resources.", "In at least one embodiment, if there is insufficient global headspace available, then the requested increase in the resource may not be executed at the time of the request.", "In some embodiments, if the global headspace for the requested increase of resources is available, then process 1300 may flow to decision block 1308; otherwise, process 1300 may flow to block 1312.In some other embodiments, if the increase in resources would exceed global thresholds and/or limitations, then the request for the increase of resources may be discarded.", "Process 1300 continues at decision block 1308, where a determination may be made whether the local resources related to the project may be capable of handling the requested increase in project resources.", "For example, in an embodiment that may be employing virtual machines, the requested increase in project resources may require that a virtual machine allocate more virtual disk space, or it may require that the virtual machine be migrated to another physical machine that may be able to accommodate the requested increase in project resources.", "In some embodiments, if such operations are unable to be resolved immediately (e.g., within a predefined time period), then the local resources may not be capable of handling the requested increase of project resources.", "If the local resources are capable of handling the requested increase in project resources, then process 1300 may flow to decision block 1310; otherwise, process 1300 may flow to block 1312 to queue the request.", "At decision block 1310, a determination may be made whether the requested increase in project resources may be arranged or configured to occur at a scheduled time in the future.", "In some embodiments, a user and/or operator may determine a scheduled time when the requested increase may occur.", "In other embodiments, the scheduled time may be predetermined, such as five minutes from when the request was received.", "In other embodiments, the scheduled time may be based on the resources requested.", "For example, if additional CPU quota is requested, then the scheduled time may be one minute from when the request was received, where a request for additional storage space may be scheduled 10 minutes from when the request was received.", "If the increase may be scheduled to occur in the future, then process 1300 may flow to block 1312 to queue the request; otherwise, process 1300 may flow to block 1314.At block 1312, the request for the increase of resources may be submitted to a queue.", "In at least one embodiment, the request may remain in the queue until conditions allow it to be fulfilled (i.e., available resources).", "One embodiment of queuing project resource requests is described in more detail below in conjunction with FIG.", "15.In some embodiments, a process or operator requesting an increase in project resources may not have knowledge of the global resource allocation.", "Queuing the requested increase in project resources may enable short running processes to finish and expire so that their released resources may be made available to a queued request for increasing project resources.", "After block 1312, process 1300 may return control to a calling process.", "If the requested increase in project resources is not queued, then process 1300 may flow to block 1314.At block 1314, the determined resources for the requested increase may be allocated.", "Embodiments for allocating resources are discussed in more detail below in conjunction with FIGS.", "16-18.After block 1314, process 1300 may return control to a calling process.", "FIG.", "14 depicts a logical flow diagram generally showing one embodiment of process for responding to a requested decrease in project resources.", "In some embodiments, process 1400 of FIG.", "14 may be implemented by and/or executed on a single network device, such as network device 400 of FIG.", "4.In other embodiments, process 1400 or portions of process 1400 of FIG.", "14 may be implemented by and/or executed on a plurality of network devices, such as network device 400 of FIG.", "4.In yet other embodiments, process 1400 or portions of process 1400 of FIG.", "14 may be implemented by and/or executed on one or more blade servers, such as blade server 250 of FIG.", "2B.", "In some embodiments, a requested decrease in project resources may require some system or computing resources to decrease while others may be required to be increased depending on how the relevant control dimension has been arranged and configured.", "Process 1400 begins, after a start block, at decision block 1402, where a determination may be made whether the requested decrease in project resources may be scheduled to occur in the future.", "In at least one embodiment, decision block 1402 may employ embodiments of decision block 1310 of FIG.", "13 to determine if a request may be scheduled to occur at a time after the request is received.", "If the decrease in project resources may be scheduled in the future, then process 1400 may flow to block 1410 to queue the request at least until the scheduled time; otherwise, process 1400 may flow to block 1404.At block 1404, the impact of the request on the project, other projects, and/or the system as a whole may be determined.", "In at least one embodiment, block 1404 may employ embodiments of block 1304 of FIG.", "13 to determine an impact of resources on the project and the system (noting that block 1304 of FIG.", "13 determines based on an increase in resources and block 1404 determines based on a decrease in resources).", "Process 1400 next proceeds to decision block 1406, where a determination may be made whether the impact of the requested decrease in project resources is unacceptable.", "In at least one embodiment, running processes of the current project may be analyzed to determine if they can run to completion under the conditions of the decreased resources.", "In one non-limiting, non-exhaustive example, a current project may not run to completion if the decrease in resources starves the project of processor time, which may be determined to be unacceptable.", "If the requested decrease in project resources is acceptable, then process 1400 may flow to block 1408; otherwise, process 1400 may flow to block 1410 to queue the request, which may enable the current processes to finish gracefully.", "But, in some embodiments a requested decrease in project resource may be arranged and configured so it may not cooperate with the running processes.", "In such cases, an embodiment may terminate the running process to avoid unpredictable outcomes that may occur if the processes try to continue to run reduced resource environment.", "At block 1410, the resource decrease request may be queued.", "An embodiment of a project resource request queue is shown in FIG.", "15.As discussed above project resource requests may be submitted to a request queue if the request may not be completed at the time it may be initiated.", "This may occur for many reasons, including lack of local or global resources, lack of authorizations that may be needed, the request may be deliberately schedule to occur in the future, currently running processes may be blocking the request, and the like.", "A project resource request queue may be arranged to hold request records that may comprise a data structure that carries the metadata that may contain the information about the resources that may have been determined necessary to execute the request.", "Such metadata may include instructions on how to allocate resources for all of the components impacted by the resource request.", "For example, a project resource request may require a CPU quota adjustment and index storage size allocation as part of a single project resource request.", "In a case like this, a queued resource request may contain metadata and instructions that may be used to executed the CPU quota change and the index storage allocation.", "In other embodiments the queued request may contain the control delta information from the component that initiated the project request and the underlying components and instructions needed to execute the request may be determined at the time of allocation.", "If, at decision block 1406, the requested decrease in project resources is acceptable, then process 1400 may flow from decision block 1406 to block 1408.At block 1408, resource allocation for the current project may be decreased.", "Embodiments for allocating resources are discussed in more detail below in conjunction with FIGS.", "16-18.After block 1408, process 1400 may return control to a calling process.", "FIG.", "15 illustrates a logical flow diagram generally showing one embodiment of process for queuing resource requests.", "In some embodiments, process 1500 of FIG.", "15 may be implemented by and/or executed on a single network device, such as network device 400 of FIG.", "4.In other embodiments, process 1500 or portions of process 1500 of FIG.", "15 may be implemented by and/or executed on a plurality of network devices, such as network device 400 of FIG.", "4.In yet other embodiments, process 1500 or portions of process 1500 of FIG.", "15 may be implemented by and/or executed on one or more blade servers, such as blade server 250 of FIG.", "2B.", "Process 1500 begins, after a start block, at decision block 1502, where a determination may be made whether there are queued requests.", "In at least one embodiment, this determination may be based on whether the queue is holding any requests.", "If the queue is holding requests, then process 1500 may flow to block 1504; otherwise, process 1500 may return control to a calling process.", "At block 1504, a next request in the queue may be examined.", "In at least one embodiment, this request examination may include a determination of the resources associated with the next request and a determination of the conditions that need to be met for the next request to be acted upon (e.g., acceptable resources available to accommodate the request).", "In some embodiments, the conditions may include the conditions that led to the next request being entered into the request queue in the first place.", "For example, the condition may include a scheduled time.", "Process 1500 next proceeds to decision block 1506, where a determination may be made whether the conditions to execute the next request are satisfied for the next request.", "For example, a next request that required prior authorization before proceeding may be tested to see if sufficient authorization has been obtained.", "Or, global resource conditions may be examined to determine if a next request that may have been queued because of a lack of available global resources now may have sufficient resources available to proceed.", "For next requests that may have been queued so they may occur at a scheduled time in the future the time may be checked.", "If the conditions for the next request are met, then process 1500 may flow to block 1508; otherwise, process 1500 may loop to decision block 1502.If conditions for the next request are not met, the process may leave the request in the queue and may examine the next request in the queue.", "In some embodiments a queue may be configured such that if a request remains in the queue longer that a specified time an additional action may be taken.", "Such actions may include, notifying the operator, generating alerts in the form of log messages or other notifications, removing the request from the queue, and the like.", "At block 1508, the determined resources based on the next request may be allocated.", "Embodiments for allocating resources are discussed in more detail below in conjunction with FIGS.", "16-18.Process 1500 continues at block 1510, where the completed request may be removed from the queue.", "In some embodiments, the next request may be configured to be returned to the queue after it has executed.", "Some requests may be scheduled to occur at a certain time each day.", "These requests may be returned to the queue to wait until the next time to execute.", "Other requests may be considered “standing” requests that may remain in the queue waiting for certain conditions to be met.", "For example, an embodiment may be arranged to automatically increase index storage as it is needed.", "In this kind of case, an embodiment may use a queued request that may execute when it determines that more index storage is needed.", "Embodiments may be arranged to have multiple project resource request queues designated for different types of requests.", "Also, embodiments may employ general purpose queues that may be used for queue project resource requests as well as other types of requests and events.", "After block 1510, process 1500 may return control to a calling process.", "As discussed briefly above, embodiments may be arranged to support elastic scaling in one or more dimensions.", "FIG.", "16 depicts a logical flow diagram generally showing one embodiment of process for elastically scaling based on index storage size.", "In some embodiments, process 1600 of FIG.", "16 may be implemented by and/or executed on a single network device, such as network device 400 of FIG.", "4.In other embodiments, process 1600 or portions of process 1600 of FIG.", "16 may be implemented by and/or executed on a plurality of network devices, such as network device 400 of FIG.", "4.In yet other embodiments, process 1600 or portions of process 1600 of FIG.", "16 may be implemented by and/or executed on one or more blade servers, such as blade server 250 of FIG.", "2B Process 1600 begins, after a start block, at block 1602, where an optimal storage size for a new index store may be determined.", "In some embodiments, optimal storage size may be static or dynamic.", "In at least one embodiment, optimal storage size may be automatically determined by rule-based systems, predictive computing techniques, or the like.", "In another embodiment, optimal storage size may be manually determined by an operator.", "The optimal size may be determined by a rule-based system tailored to the specific project that owns the index store.", "An embodiment of a rule-based system for elastic scaling may employ triggers linked to performance and resource thresholds.", "Different projects may be configured to have different triggers and different thresholds depending on the requirements of the project.", "In addition to rule-based determination, the optimal size for index store may be determined by an operator using a user-interface control such as a slider, dial, radio buttons, and the like.", "Even though an operator has used a control to determine the optimal size, an embodiment may translate the operation of the control into the actual optimal index store size.", "For example, an operator may use a user interface to control to increase an index store from 5 gigabytes to 10 gigabytes.", "In this case an embodiment may have to make several determinations to account for the actual storage size needed to account for administration overhead that may not be apparent to the operator.", "Process 1600 continues at block 1604, where new storage may be allocated and/or formatted to accommodate the elastic scaling of the index store.", "New storage may be created so the current index store may not be altered or disturbed during the elastic scaling process.", "Process 1600 proceeds next to block 1606, where new objects and/or processes may be allocated and/or instantiated to optimally service the scaled new index store.", "Embodiments may create new objects and processes to avoid disturbing the current index store during the elastic scaling process.", "Continuing at block 1608, the new index store may be determined.", "At least one embodiment for determining a new index store is described in more detail below in conjunction with FIG.", "19.Briefly, however, in some embodiments indexers may be activated (i.e., marked as read/write) or deactivated (i.e., marked as read-only based on a number of indexers needed for the scaled new index store storage.", "In some other embodiments, the current index store may be marked as read-only and the new index store may be generated from new indexers.", "This may ensure that the all new writes to the index store may be written into the scaled new index store storage.", "Process 1600 next proceeds to block 1610, which is discussed in more detail below in conjunction with FIG.", "22.Briefly, however, at block 1610, an input proxy may be directed to use the scaled new index store for the indexing of incoming events.", "Process 1600 continues at block 1612, where the new objects and/or processes may be employed to index incoming events using the scaled new index store.", "In at least one embodiment, incoming events and/or incoming data may include new events/data and/or archived events/data.", "In at least one embodiment, the scaled new index store may be utilized based on Roles of the new indexes.", "In some embodiments, new indexes (which may include the new objects, new processes, or the like) may be automatically added to existing indexes (which may include the existing objects, existing processes, or the like).", "In at least one embodiment, the new indexes may be attached to and/or inherit Roles associated with the existing indexes for at least one Core User of the project.", "In such an embodiment, the input proxy may utilize the inherited Roles during a scaling event to determine when to send incoming events (and/or other data) to the new indexes.", "As described above, the Roles may determine access controls to the indexes.", "After block 1612, process 1600 may return control to a calling process.", "FIG.", "17 depicts a logical flow diagram generally showing one embodiment of a process for elastically scaling based on indexing performance.", "In some embodiments, process 1700 of FIG.", "17 may be implemented by and/or executed on a single network device, such as network device 400 of FIG.", "4.In other embodiments, process 1700 or portions of process 1700 of FIG.", "17 may be implemented by and/or executed on a plurality of network devices, such as network device 400 of FIG.", "4.In yet other embodiments, process 1700 or portions of process 1700 of FIG.", "17 may be implemented by and/or executed on one or more blade servers, such as blade server 250 of FIG.", "2B.", "Indexing performance may be a compound elastic scaling dimension that may be generally related to speed of the processing for a project.", "For many embodiments multiple component resources, such CPU quota, network bandwidth quota, RAM quota, index storage, and like, may be scaled to execute elastic scaling based on Indexing Performance.", "Process 1700 begins, after a start block, at block 1702, where resources needed for optimal indexing performance may be determined.", "In at least one embodiment, optimal indexing performance may be automatically determined by rule-based systems, predictive computing techniques, or the like.", "In another embodiment, optimal indexing performance may be manually determined by an operator.", "The specific resources needed may be determined by a rule-based system tailored to a specific project.", "An embodiment of a rule-based system for elastic scaling may employ triggers linked to performance and resource thresholds.", "Different projects may be configured to have different triggers and different thresholds depending on the requirements of the project.", "In addition to rule-based determination the optimal resource allocation may be determined by an operator using a user-interface control such as a slider, dial, radio buttons, and the like.", "Even though an operator may use a control to determine the optimal indexing performance an embodiment may translate the operation of the control into the actual optimal allocation of resources.", "For example, an operator may use a user interface to control to increase a projects indexing performance from “low” to “high.” However, in this case an embodiment may have to make several determinations to account for CPU quota, disk access quota, RAM quota, storage size, and the like, the details of which may not be apparent to the operator.", "Process 1700 proceeds to block 1704, where new storage may be allocated and/or formatted to accommodate the elastic scaling of the indexing performance.", "An embodiment may allocate and format a new storage even if the size of the data store has not increase or decrease.", "New storage may be created so the current index store may not be altered or disturbed during the elastic scaling process.", "Processing continues at block 1706, where new objects and/or processes may be allocated and/or instantiated to optimally support the determined indexing performance requirements.", "Embodiments may create new objects and processes to avoid disturbing the current index store during the elastic scaling process.", "Process 1700 proceeds next at block 1708, where the new index store may be determined.", "In at least one embodiment, block 1708 may employ embodiments of block 1608 of FIG.", "16 to determine the new index store.", "Process 1700 continues next at block 1710, which is discussed in more detail below in conjunction with FIG.", "22 Briefly, however, at block 1710, an input proxy may be directed to use the scaled new index store for the indexing of incoming events.", "Process 1700 proceeds to block 1712, where the new objects and/or processes may be employed to index incoming events using the scaled new index store.", "In at least one embodiment, incoming events and/or incoming data may include new events/data and/or archived events/data.", "In at least one embodiment, block 1712 may employ embodiments of block 1612 of FIG.", "16 to use the scaled new index store.", "After block 1712, process 1700 may return control to a calling process.", "FIG.", "18 depicts a logical flow diagram generally showing one embodiment of a process for elastically scaling based on an event time window.", "In some embodiments, process 1800 of FIG.", "18 may be implemented by and/or executed on a single network device, such as network device 400 of FIG.", "4.In other embodiments, process 1800 or portions of process 1800 of FIG.", "18 may be implemented by and/or executed on a plurality of network devices, such as network device 400 of FIG.", "4.In yet other embodiments, process 1800 or portions of process 1800 of FIG.", "18 may be implemented by and/or executed on one or more blade servers, such as blade server 250 of FIG.", "2B.", "Event time window may be a compound elastic scaling dimension that may be generally related to the index storage sizes for a project.", "An embodiment may be arranged to receive data such that the index store may be sufficient to hold data received during a determined time window.", "A time window may be described as date-time expression such as, a start date-time and an end date-time, a duration, such as 30 days, start date-time plus a duration, and the like.", "For many embodiments multiple component resources, such CPU quota, network bandwidth quota, RAM quota, index storage, and like, may be scaled to execute elastic scaling based on event time windows.", "Process 1800 begins, after a start block, at block 1802, where a new event time window may be determined.", "The event time window may be submitted as a complete time duration expression or it may be dynamically determined based on past event traffic and predicted future event traffic or any method to describe a time window for capturing events.", "Process 1800 proceeds next to block 1804, where resources needed for indexing data for the determined event time window may be determined.", "The specific resources needed may be determined by a rule-based system tailored for specific projects.", "An embodiment of a rule-based system for elastic scaling may employ triggers linked to performance and resource thresholds.", "Different projects may be configured to have different triggers and different thresholds depending on the requirements of the project.", "In addition to rule-based determination, the optimal resource allocation may be determined by an operator using a user-interface control such as a slider, dial, radio buttons, and the like.", "Even though an operator may use a control to determine the optimal indexing performance an embodiment may translate the operation of the control into the actual optimal allocation of resources.", "For example, an operator may use a user interface control to increase a project's event time window from “10 days” to “30 days.” However, in this case an embodiment may have to make several determinations to account for CPU quota, disk access quota, RAM quota, storage size, and the like, the details of which may not be apparent to the operator.", "In any event, process 1800 continues at block 1806, where new storage may be allocated and/or formatted to accommodate the elastic scaling of the determined event time window in the new index store.", "New storage may be created so the current index store may not be altered or disturbed during the elastic scaling process.", "Process 1800 proceeds to block 1808, where new objects and/or processes may be allocated and/or instantiated to optimally support the determined event time window.", "Embodiments may create new objects and processes to avoid disturbing the current index store during the elastic scaling process.", "Continuing to block 1810, the new index store may be determined.", "In at least one embodiment, block 1708 may employ embodiments of block 1608 of FIG.", "16 to determine the new index store.", "Process 1800 proceeds next to block 1812, which is discussed in more detail below in conjunction with FIG.", "22.Briefly, however, at block 1812, an input proxy may be directed to use the scaled new index store for the indexing of incoming data.", "Process 1800 continues to block 1814, where the new objects and/or processes may be employed for indexing incoming data using the scaled new index store.", "In at least one embodiment, incoming events and/or incoming data may include new events/data and/or archived events/data.", "In at least one embodiment, block 1814 may employ embodiments of block 1612 of FIG.", "16 to use the scaled new index store.", "After block 1814, process 1800 may return control to a calling process.", "FIG.", "19, illustrates a logical flow diagram generally showing one embodiment of a process for changing a number of indexers associated with an index store.", "In some embodiments, process 1900 of FIG.", "19 may be implemented by and/or executed on a single network device, such as network device 400 of FIG.", "4.In other embodiments, process 1900 or portions of process 1900 of FIG.", "19 may be implemented by and/or executed on a plurality of network devices, such as network device 400 of FIG.", "4.In yet other embodiments, process 1900 or portions of process 1900 of FIG.", "19 may be implemented by and/or executed on one or more blade servers, such as blade server 250 of FIG.", "2B.", "Although process 1900 describes changing a number of indexers, in some embodiments, changing a number of indexers (e.g., indexer servers) may also include changing an amount of resources associated with a project, such as, for example, storage, objects, processors, or the like.", "In at least one embodiment, adding additional indexers may include adding additional storage space and/or processors (and/or other resources).", "In another embodiment, reducing a number of indexers may include reducing storage space and/or processors (and/or other resources.", "In yet other embodiments, resources for a given indexer server may also be changed.", "In some embodiments, resources of an indexer server may be changed by changing a number of indexes used by a project, which may also change an amount of storage, processing capacity, or the like for the project.", "Process 1900 begins, after a start block, at decision block 1902, where a determination may be made whether additional indexers may be added to the index store.", "In at least one embodiment, the determination may be based on the elastic scaling.", "In some embodiments, if the storage size and/or the performance are increased, then indexers may be added to the index store.", "If indexers may be added to the index store, then process 1900 may flow to decision block 1904; otherwise, process 1900 may flow to decision block 1906.At decision block 1906, a determination may be made whether to remove indexers from the index store.", "In at least one embodiment, the determination may be based on the elastic scaling.", "In some embodiments, if the storage size and/or the performance are decreased, then indexers may be removed from the index store.", "If indexers may be removed from the index store, then process 1900 may flow to block 1908; otherwise, process 1900 may return control to a calling process.", "At block 1908, at least one indexer may be deactivated.", "In some embodiments, de-activating an indexer may include marking the indexer as read-only.", "In at least one embodiment, a read-only indexer may indicate that the indexer is not currently active for the new index store.", "In some embodiments, a determination may be made on which indexers to deactivate based on time (e.g., creation time, last modified time, last access time, or the like), size of the indexer, or the like.", "In at least one embodiment, a user may be prevented from accessing a deactivated indexer.", "In some embodiments, if the indexer is deactivated for a period of time, then the data may be removed from the deactivated indexer (e.g., deleted and/or moved to archival storage).", "If, at decision block 1902, additional indexers may be added to the index store, then processing may flow from decision block 1902 to decision block 1904.At decision block 1904, a determination may be made whether there are deactivated indexers (such as were deactivated at block 1908).", "If there are deactivated indexers, then process 1900 may flow to block 1912; otherwise, process 1900 may flow to block 1910.At block 1912, at least one currently deactivated indexer may be activated and added to the new index store.", "In at least one embodiment, activating may include marking a read-only indexer as a read/write indexer.", "After block 1912, process 1900 may return control to a calling process.", "If, at decision block 1904, there are no deactivated indexers, then process 1900 may flow from decision block 1904 to block 1910.At block 1910, new indexers may be added to the new index store.", "After block 1910, process 1900 may return control to a calling process.", "FIG.", "20 shows a logical flow diagram generally showing one embodiment of a process to recall archived data for re-indexing.", "In some embodiments, process 2000 of FIG.", "20 may be implemented by and/or executed on a single network device, such as network device 400 of FIG.", "4.In other embodiments, process 2000 or portions of process 2000 of FIG.", "20 may be implemented by and/or executed on a plurality of network devices, such as network device 400 of FIG.", "4.In yet other embodiments, process 2000 or portions of process 2000 of FIG.", "20 may be implemented by and/or executed on one or more blade servers, such as blade server 250 of FIG.", "2B.", "Embodiments may be arranged to archive input data as it is indexed.", "(See, input proxy, as shown in FIG.", "22, for more details about archiving.)", "Data stored in the archives may be in the same format and form as it was sent to the input proxy.", "A process may process data from the archive and create indexes from the data.", "This may enable operators to re-create indexes from the archived data and it may enable operators to create new indexes that may be processed differently from the indexes that may have been created when the data was first received.", "Process 2000 begins, after a start block, at block 2002, where a time window of events may be determined for re-indexing.", "The time windows may be determined be a rule-based algorithm that may automatically determine the time window or an operator may select the time window manually using a user interface.", "Process 2000 continues at block 2004, where event data records may be retrieved from the archive.", "Process 2000 proceeds next to block 2000, where the retrieved event data records are indexed using the current project's parameters.", "Recall of archived event data may occur in the context of a new project or it may occur as part of an existing project.", "Processing continues at decision block 2008, where a determination may be made whether, there are additional records remaining in the archive.", "In some embodiments, the process may continue to retrieve records and index them from the archive until all the data within the determined time window has been exhausted.", "In some embodiments a recall process may be aborted or paused based on operator intervention or when determined performance thresholds have been reached.", "If there are records remaining in the archive, then process 2000 may loop to block 2004; otherwise, process 2000 may return control to a calling process.", "As described above, a new scaled index store may be employed based on elastic scaling.", "In some embodiments, data from a previous index store may remain available while the new scaled index store is employed.", "FIG.", "21 illustrates a logical flow diagram generally showing one embodiment of a process for transitioning to scaled index stores.", "In some embodiments, process 2100 of FIG.", "21 may be implemented by and/or executed on a single network device, such as network device 400 of FIG.", "4.In other embodiments, process 2100 or portions of process 2100 of FIG.", "21 may be implemented by and/or executed on a plurality of network devices, such as network device 400 of FIG.", "4.In yet other embodiments, process 2100 or portions of process 2100 of FIG.", "21 may be implemented by and/or executed on one or more blade servers, such as blade server 250 of FIG.", "2B.", "Process 2100 begins, after a start block, at block 2102, where event data may be received from an input proxy.", "Embodiments of employing an input proxy are described in more detail below in conjunction with FIG.", "22.Process 2100 next proceeds to block 2104, where the received event data may be indexed.", "In at least one embodiment, the indexed event data may be stored in the new scaled index store.", "Process 2100 continues at block 2106, where the total storage for the new events stored in the scaled new index store and the old event that may be stored in the previously used read-only index store may be determined.", "Proceeding to decision block 2108, a determination may be made whether the total amount of storage used is greater than the amount of stated provisioned for the project.", "If the total storage used is greater than the amount of storage provisioned for the project, then process 2100 may flow to block 2110; otherwise, process 2100 may loop back to block 2102 to receive additional event data from the Input Proxy.", "At block 2110, the index records in the previously provisioned storage may be marked for archival or removal.", "For the index records marked for archival, process 2100 may flow to block 2112; for the index records marked for removal, process 2100 may flow to block 2114.At block 2110, the index records marked for archival may be copied from the previously provisioned storage to archival storage.", "At block 2114, the index records marked for removal may be deleted from the previously provisioned storage.", "In some embodiments, index records marked from archive may be deleted from the previously provisioned storage after being copied to the archival storage.", "After block 2114, process 2100 may return control to a calling process.", "As described above, some embodiments may enable the operation of an input proxy.", "FIG.", "22 illustrates a logical flow diagram generally showing one embodiment of an input proxy operation.", "In some embodiments, process 2200 of FIG.", "22 may be implemented by and/or executed on a single network device, such as network device 400 of FIG.", "4.In other embodiments, process 2200 or portions of process 2200 of FIG.", "22 may be implemented by and/or executed on a plurality of network devices, such as network device 400 of FIG.", "4.In yet other embodiments, process 2200 or portions of process 2200 of FIG.", "22 may be implemented by and/or executed on one or more blade servers, such as blade server 250 of FIG.", "2B.", "Process 2200 begins, after a start block, at block 2202 where the proxy may receive data.", "The data may be received from remote clients and sources.", "The data source may stream the data to the input proxy using various networking technologies, including, Ethernet, 802.11 (a, b, g, and n), Bluetooth, TCP/IP, UDP, HTTP, internal specific point-to-point protocol, and the like.", "In some embodiments, the proxy may throttle (increase or decrease) a rate at which data incoming data is streamed.", "In at least one embodiment, the data rate may be based on a corresponding project.", "For example, the data rate may be based on an amount of storage space allocated for the project (e.g., an amount of storage space purchased by a user for the project).", "The data may be received and a process may “tee” the data, sending it down at least two paths at the same time, which may be depicted in FIG.", "22 as Path A and Path B.", "Proceeding on Path A, process 2200 may proceed from block 2202 to block 2204.At block 2204, the raw data may be load balanced to determine which indexer to use.", "Process 2200 continues next at block 2206, where the received data may be indexed on the load balanced indexers.", "In some embodiments, a size of each indexer may not be limited.", "In other embodiments, the size of each indexer may be limited.", "In one such embodiment, an amount of data per indexer may be monitored.", "In one embodiment, the monitoring may be asynchronous to incoming data.", "In some embodiment, if a limit for an indexer is reached or almost reached (e.g., less than 5% remaining), then a message may be sent to a user to indicate that the indexer limit is reached or almost reached.", "In some other embodiments, indexing may be disabled if a user exceeds purchased resource allocation.", "In at least one embodiment, indexing may be disabled if a user and/or project exceeds an allocated storage size (e.g., previously purchased amount of storage).", "In another embodiment, indexing may be disabled if a user discontinues paying for the indexing.", "In yet another embodiment, indexing may be disabled if a user and/or project exceeds a number of buckets for the project.", "Process 2200 next proceeds to block 2208, where the indexed data and event records may be stored in the project's index store.", "Proceeding on Path B, process 2200 may proceed from block 2202 to block 2210.At block 2210, the raw data may be sent to be copied to intermediate storage.", "The intermediate storage may be arranged to be available, fast and reliable.", "Embodiments may employ a FIFO buffer implemented by local hard disks, RAID arrays, and the like, to ensure that the raw data is not lost.", "Process 2200 continues at block 2212, where the data may be archived as archival storage becomes available.", "Moving the raw data from the intermediate storage to the long term archive may be executed by a separate process that reliably moves the raw data from the intermediate storage to the long term storage.", "After block 2208 and 2212, process 2200 may return control to a calling process.", "It will be understood that each block of the flowchart illustration, and combinations of blocks in the flowchart illustration, can be implemented by computer program instructions.", "These program instructions may be provided to a processor to produce a machine, such that the instructions, which execute on the processor, create means for implementing the actions specified in the flowchart block or blocks.", "The computer program instructions may be executed by a processor to cause a series of operational steps to be performed by the processor to produce a computer-implemented process such that the instructions, which execute on the processor to provide steps for implementing the actions specified in the flowchart block or blocks.", "The computer program instructions may also cause at least some of the operational steps shown in the blocks of the flowchart to be performed in parallel.", "Moreover, some of the steps may also be performed across more than one processor, such as might arise in a multi-processor computer system.", "In addition, one or more blocks or combinations of blocks in the flowchart illustration may also be performed concurrently with other blocks or combinations of blocks, or even in a different sequence than illustrated.", "Accordingly, blocks of the flowchart illustration support combinations of means for performing the specified actions, combinations of steps for performing the specified actions and program instruction means for performing the specified actions.", "It will also be understood that each block of the flowchart illustration, and combinations of blocks in the flowchart illustration, can be implemented by special purpose hardware-based systems, which perform the specified actions or steps, or combinations of special purpose hardware and computer instructions.", "Use Case Illustration FIG.", "23 illustrates a non-exhaustive example of a use case of an embodiment of user-interface controls that may be employed to enable elastic scaling.", "As shown in FIG.", "23, an embodiment may be arranged to provide user-interface controls, such as sliders, dials, radio buttons, spinners, touch controls, gesture controls, and the like, that may enable an operator to elastically scale resources that may be associated with a project.", "One exemplary user-interface is shown in the FIG.", "23.This may represent a user-interface having three slider controls for controlling the resource for the project.", "As shown in FIG.", "23, a slider control (e.g., control 2302, control 2304, and/or control 2306) may generally comprise a slider 2308 and a slider thumb 2310.An operator may manipulate the slider thumb 2310 by moving it forward or backwards lengthwise within the slider 2308.The movement of the slider thumb 2310 may generate intermediate values that may be used for determining corresponding to elastic scaling values.", "The embodiment depicted in FIG.", "23 has three slider controls.", "Control 2302, on the top of the figure, may be use for the elastic scaling of index storage size.", "Control, in the center of the figure, may be used for the elastic scaling of the number of server instances the may be used to support a project.", "And, control 2306, at the bottom of the figure, may be used to set the index storage size by event time window.", "Control 2302 may also include text box 2312 and text box 2314.In at least one embodiment, text box 2312 may display the current value represented by the position of slider thumb 2310 in slider 2308.In some other embodiments, text box 2312 may enable a user to enter a desired value, and slider thumb 2310 may automatically slide to the corresponding position in slider 2308.In another embodiment, text box 2314 may display how much the current value (i.e., what is displayed in text box 2312) of control 2302 will cost the owner of the project.", "In some other embodiments, text box 2314 may enable a user to enter a desired cost, and slider thumb 2310 may automatically slide to the corresponding position in slider 2308.As shown, each slider control may include text box 2312 and/or text box 2314.However, it should be appreciated that embodiments are not restricted to arranging text boxes as depicted herein.", "Embodiments may be expected to use a variety of user interface methods to indicate the current value of the controls and well as how much the selected value may cost.", "Also, embodiments may be arranged to display values different and in addition to those depicted herein, or none at all.", "Some embodiments may arrange for the user interface controls to use different scales for the variables different that may be represented by the control, such as, linear (as illustrated by control 2302), logarithmic (as illustrated by control 2306), parametric (as illustrated by control 2304), and the like.", "An embodiment may be arranged to use a particular scale based on the type of user-interface being used and the resource that may be represented.", "In some cases, the scale of the control may be determined based on how the user may be charged for the underlying resource.", "For example, if a linear increase in the number of server instances many have a logarithmic increase in the cost to the user it may be advantageous to scale the control to account for the change in cost rather than the change in resources.", "In some embodiments multiple controls may be linked together such that adjusting one control may cause another control to adjust as well.", "Also, embodiments may provide additional user controls (not shown), such as, checkboxes, that may enable a user to lock a control so it may remain in a fixed position as other controls are adjusted.", "In other embodiments, some controls may represent high level, generalized, or aggregated representations of resources, in this case a user may select a higher level control and “drill-down” into the underlying elements that the high level, generalized, or aggregated control may be representing.", "One of ordinary skill in the art will appreciate that the three controls depicted in the embodiment shown in FIG.", "23 are merely exemplary and many other configurations and arrangements could be used.", "The above specification, examples, and data provide a complete description of the composition, manufacture, and use of the invention.", "Since many embodiments of the invention can be made without departing from the spirit and scope of the invention, the invention resides in the claims hereinafter appended." ] ]
Patent_15872837
[ [ "UNIFORM ELECTROCHEMICAL PLATING OF METAL ONTO ARRAYS OF PILLARS HAVING DIFFERENT LATERAL DENSITIES AND RELATED TECHNOLOGY", "A semiconductor die assembly in accordance with an embodiment of the present technology includes first and second semiconductor dies spaced apart from one another.", "The first semiconductor die has a major surface with non-overlapping first and second regions.", "The semiconductor die assembly further includes an array of first pillars extending heightwise from the first region of the major surface of the first semiconductor die toward the second semiconductor die.", "Similarly, the semiconductor die assembly includes an array of second pillars extending heightwise from the second region of the major surface of the first semiconductor die toward the second semiconductor die.", "The first and second pillars have different lateral densities and different average widths.", "The latter difference at least partially offsets an effect of the former difference on relative metal deposition rates of an electrochemical plating process used to form the first and second pillars." ], [ "1.A semiconductor die assembly, comprising: a first semiconductor die having a major surface with non-overlapping first and second regions; a second semiconductor die spaced apart from the first semiconductor die; an array of first pillars extending heightwise from the first region of the major surface of the first semiconductor die toward the second semiconductor die, wherein the first pillars are configured to carry electricity between the first and second semiconductor dies; and an array of second pillars extending heightwise from the second region of the major surface of the first semiconductor die toward the second semiconductor die, wherein the second pillars are electrically insulated from one or both of the first and second semiconductor dies, wherein— a minimum lateral spacing between the first pillars is different than a minimum lateral spacing between the second pillars by at least 5%, and an average width of the first pillars is different than an average width of the second pillars by at least 2%.", "2.The semiconductor die assembly of claim 1 wherein: the minimum lateral spacing between the first pillars is lower than the minimum lateral spacing between the second pillars; and the average width of the first pillars is greater than the average width of the second pillars.", "3.The semiconductor die assembly of claim 1 wherein: the minimum lateral spacing between the first pillars is lower than the minimum lateral spacing between the second pillars; and the average width of the first pillars is less than the average width of the second pillars.", "4.The semiconductor die assembly of claim 1 wherein the second pillars are configured to carry heat between the first and second semiconductor dies.", "5.The semiconductor die assembly of claim 1 wherein the minimum lateral spacing between the first pillars is different than the minimum lateral spacing between the second pillars by at least 10%.", "6.The semiconductor die assembly of claim 5 wherein the average width of the first pillars is different than the average width of the second pillars by at least 5%.", "7.A semiconductor die assembly, comprising: a first semiconductor die having a major surface with a first region and a second region discrete from the first region; a second semiconductor die spaced apart from the first semiconductor die; an array of first pillars extending heightwise from the first region of the major surface of the first semiconductor die toward the second semiconductor die; and an array of second pillars extending heightwise from the second region of the major surface of the first semiconductor die toward the second semiconductor die, dummy pillars interspersed among the first pillars, wherein— a minimum lateral spacing between the first pillars is different than a minimum lateral spacing between the second pillars by at least 5%, and an average height of the dummy pillars is at least 10% less than an average height of the first pillars.", "8.The semiconductor die assembly of claim 7 wherein an average width of the first pillars is different than an average width of the second pillars by at most 3%.", "9.The semiconductor die assembly of claim 7 wherein: the first pillars are configured to carry electricity between the first and second semiconductor dies; and the second pillars are electrically insulated from one or both of the first and second semiconductor dies.", "10.The semiconductor die assembly of claim 7, further comprising volumes of solder respectively disposed between the respective first pillars and the second semiconductor die.", "11.The semiconductor die assembly of claim 10, further comprising bond pads respectively disposed between the respective volumes of solder and the second semiconductor die.", "12.The semiconductor die assembly of claim 7 wherein: the dummy pillars are first dummy pillars; the semiconductor die assembly further comprises second dummy pillars; a minimum lateral spacing between the first dummy pillars and the first pillars is less than a minimum lateral spacing between the second dummy pillars and the first pillars; and an average width of the second dummy pillars is less than an average width of the first dummy pillars.", "13.The semiconductor die assembly of claim 12 wherein an average height of the second dummy pillars is less than an average height of the first dummy pillars.", "14.The semiconductor die assembly of claim 12 wherein the minimum lateral spacing between the first pillars is different than the minimum lateral spacing between the second pillars by at least 10%.", "15.A method for making a semiconductor die assembly, the method comprising: electrochemically plating metal by an electrochemical plating process onto an array of first pillars extending heightwise from a first region of a major surface of a semiconductor die; and simultaneously electrochemically plating metal by the electrochemical plating process onto an array of second pillars extending heightwise from a non-overlapping second region of the major surface of the semiconductor die, wherein— a difference between a minimum lateral spacing between the first pillars and a minimum lateral spacing between the second pillars has a first effect on relative metal deposition rates of the electrochemical plating process at the first and second regions of the major surface of the semiconductor die, a difference between an average width of the first pillars and an average width of the second pillars has a second effect on the relative metal deposition rates of the electrochemical plating process at the first and second regions of the major surface of the semiconductor die, and the second effect at least partially offsets the first effect.", "16.The method of claim 15 wherein: the semiconductor die is a first semiconductor die; and the method further comprises— electrically coupling the first semiconductor die to a second semiconductor die via the first pillars, and thermally coupling the first semiconductor die to the second semiconductor die via the second pillars.", "17.The method of claim 16 wherein electrically coupling the first semiconductor die to the second semiconductor die via the first pillars includes electrically coupling the first semiconductor die to the second semiconductor die via the first pillars and via solder between the first pillars and the second semiconductor die.", "18.The method of claim 15 wherein: the first effect causes a difference between an average plated height of the first pillars after the electrochemical plating process and an average plated height of the second pillars after the electrochemical plating process; and the second effect reduces the difference by at least 50%.", "19.The method of claim 15 wherein: the first effect causes a difference between a maximum plated height of any of the first and second pillars after the electrochemical plating process and a minimum plated height of any of the first and second pillars after the electrochemical plating process; and the second effect reduces the difference by at least 5%.", "20.The method of claim 15, further comprising forming respective patterns for the arrays of first and second pillars by photolithography." ], [ "<SOH> BACKGROUND <EOH>Packaged semiconductor dies, including memory chips, microprocessor chips, and imager chips, typically include a semiconductor die mounted on a substrate and encased in a plastic protective covering.", "The die includes functional features, such as memory cells, processor circuits, and imager devices, as well as bond pads electrically connected to the functional features.", "The bond pads can be electrically connected to terminals outside the protective covering to allow the die to be connected to higher level circuitry.", "Market pressures continually drive semiconductor manufacturers to reduce the size of die packages to fit within the space constraints of electronic devices, while concurrently increasing the functional capacity of each package to meet operating parameters.", "One approach for increasing the processing power of a semiconductor package without substantially increasing the surface area covered by the package (i.e., the package's “footprint”) is to vertically stack multiple semiconductor dies on top of one another in a single package.", "The dies in such vertically-stacked packages can be electrically and thermally interconnected by arrays of pillars.", "A common approach to forming these pillars includes forming a photoresist pattern that masks portions of the die surface other than portions at which the pillars are to be formed.", "After the photoresist pattern is formed, metal is electrochemically plated onto the unmasked portion of the die surface.", "Finally, the photoresist around the newly formed pillars is removed.", "A challenge associated with electrochemical plating of metal onto pillars in semiconductor die assemblies is that, in practice, the plated metal tends to be non-uniform in height among pillars throughout a given die and/or among pillars throughout a given wafer.", "These non-uniformities can complicate forming reliable electrical and thermal connections between neighboring dies.", "For example, when neighboring dies in a semiconductor die assembly are brought together during manufacturing, gaps between pillars on one of the dies and corresponding bond pads on the neighboring die may vary considerably when the pillars have variable heights and the bond pads are coplanar.", "In the context of electrical-interconnect pillars, when a pillar-to-bond-pad gap is too large to be bridged by solder, an entire package may inoperative and need to be scrapped.", "Similarly, in the context of thermal pillars, when a pillar-to-bond-pad gap is excessively large, the rate at which heat is dissipated from semiconductor dies in the package may be unacceptably low." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>FIG.", "1 is a side view of a semiconductor die assembly in accordance with an embodiment of the present technology.", "FIG.", "2 is an enlarged view of a portion of FIG.", "1 .", "FIG.", "3 is an enlarged cross-sectional view of a portion of the semiconductor die assembly of FIG.", "1 corresponding to the portion shown in FIG.", "2 taken along the line 3 - 3 in FIG.", "2 .", "FIG.", "4 is a further enlarged top plan view of two pillars of the semiconductor die assembly of FIG.", "1 .", "FIG.", "5 is a cross-sectional view similar to FIG.", "3 showing a portion of a semiconductor die assembly in accordance with another embodiment of the present technology.", "FIG.", "6 is an enlarged top plan view of two pillars of the semiconductor die assembly of FIG.", "5 .", "FIG.", "7 is a cross-sectional view similar to FIG.", "3 showing a portion of a semiconductor die assembly in accordance with another embodiment of the present technology.", "FIG.", "8 is an enlarged top plan view of a cluster of pillars of the semiconductor die assembly of FIG.", "7 .", "FIG.", "9 is a cross-sectional view of the cluster of pillars of the semiconductor die assembly of FIG.", "7 taken along the line 9 - 9 in FIG.", "8 .", "FIG.", "10 is an enlarged top plan view of a cluster of pillars of a semiconductor die assembly in accordance with another embodiment of the present technology.", "FIG.", "11 is a cross-sectional view of the cluster of pillars of FIG.", "10 taken along the line 11 - 11 in FIG.", "10 .", "FIG.", "12 is a flow chart illustrating a method for making a semiconductor die assembly in accordance with an embodiment of the present technology.", "FIG.", "13 is a flow chart illustrating a method for designing arrays of electrochemically plated pillars in a semiconductor die assembly in accordance with an embodiment of the present technology.", "FIG.", "14 is a schematic view of a system that includes a semiconductor die assembly in accordance with an embodiment of the present technology.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. application Ser.", "No.", "15/380,877, filed Dec. 15, 2016, which is incorporated herein by reference in its entirety.", "TECHNICAL FIELD The present technology is related to packaged semiconductor dies.", "BACKGROUND Packaged semiconductor dies, including memory chips, microprocessor chips, and imager chips, typically include a semiconductor die mounted on a substrate and encased in a plastic protective covering.", "The die includes functional features, such as memory cells, processor circuits, and imager devices, as well as bond pads electrically connected to the functional features.", "The bond pads can be electrically connected to terminals outside the protective covering to allow the die to be connected to higher level circuitry.", "Market pressures continually drive semiconductor manufacturers to reduce the size of die packages to fit within the space constraints of electronic devices, while concurrently increasing the functional capacity of each package to meet operating parameters.", "One approach for increasing the processing power of a semiconductor package without substantially increasing the surface area covered by the package (i.e., the package's “footprint”) is to vertically stack multiple semiconductor dies on top of one another in a single package.", "The dies in such vertically-stacked packages can be electrically and thermally interconnected by arrays of pillars.", "A common approach to forming these pillars includes forming a photoresist pattern that masks portions of the die surface other than portions at which the pillars are to be formed.", "After the photoresist pattern is formed, metal is electrochemically plated onto the unmasked portion of the die surface.", "Finally, the photoresist around the newly formed pillars is removed.", "A challenge associated with electrochemical plating of metal onto pillars in semiconductor die assemblies is that, in practice, the plated metal tends to be non-uniform in height among pillars throughout a given die and/or among pillars throughout a given wafer.", "These non-uniformities can complicate forming reliable electrical and thermal connections between neighboring dies.", "For example, when neighboring dies in a semiconductor die assembly are brought together during manufacturing, gaps between pillars on one of the dies and corresponding bond pads on the neighboring die may vary considerably when the pillars have variable heights and the bond pads are coplanar.", "In the context of electrical-interconnect pillars, when a pillar-to-bond-pad gap is too large to be bridged by solder, an entire package may inoperative and need to be scrapped.", "Similarly, in the context of thermal pillars, when a pillar-to-bond-pad gap is excessively large, the rate at which heat is dissipated from semiconductor dies in the package may be unacceptably low.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a side view of a semiconductor die assembly in accordance with an embodiment of the present technology.", "FIG.", "2 is an enlarged view of a portion of FIG.", "1.FIG.", "3 is an enlarged cross-sectional view of a portion of the semiconductor die assembly of FIG.", "1 corresponding to the portion shown in FIG.", "2 taken along the line 3-3 in FIG.", "2.FIG.", "4 is a further enlarged top plan view of two pillars of the semiconductor die assembly of FIG.", "1.FIG.", "5 is a cross-sectional view similar to FIG.", "3 showing a portion of a semiconductor die assembly in accordance with another embodiment of the present technology.", "FIG.", "6 is an enlarged top plan view of two pillars of the semiconductor die assembly of FIG.", "5.FIG.", "7 is a cross-sectional view similar to FIG.", "3 showing a portion of a semiconductor die assembly in accordance with another embodiment of the present technology.", "FIG.", "8 is an enlarged top plan view of a cluster of pillars of the semiconductor die assembly of FIG.", "7.FIG.", "9 is a cross-sectional view of the cluster of pillars of the semiconductor die assembly of FIG.", "7 taken along the line 9-9 in FIG.", "8.FIG.", "10 is an enlarged top plan view of a cluster of pillars of a semiconductor die assembly in accordance with another embodiment of the present technology.", "FIG.", "11 is a cross-sectional view of the cluster of pillars of FIG.", "10 taken along the line 11-11 in FIG.", "10.FIG.", "12 is a flow chart illustrating a method for making a semiconductor die assembly in accordance with an embodiment of the present technology.", "FIG.", "13 is a flow chart illustrating a method for designing arrays of electrochemically plated pillars in a semiconductor die assembly in accordance with an embodiment of the present technology.", "FIG.", "14 is a schematic view of a system that includes a semiconductor die assembly in accordance with an embodiment of the present technology.", "DETAILED DESCRIPTION As discussed above, pillars formed by conventional electrochemical plating processes often have non-uniform heights.", "This undesirable property typically results from local variation in the rate of metal deposition for the electrochemical plating processes used to form the pillars.", "In at least some cases, differing lateral densities of pillars in different regions of a die contribute to this local variation in metal deposition rate.", "Depending on the chemistry, electrical properties, and/or other factors during electroplating, greater lateral densities of pillars can be associated with higher or lower local metal deposition rates and, correspondingly, greater or lesser local pillar heights.", "Differing lateral densities of pillars in different regions of a die may, however, be desirable for other reasons.", "For example, the need to prevent electrical shorts or capacitance may necessitate a minimum lateral density for electrical-interconnect pillars that does not apply to thermal pillars.", "Thus, thermal pillars in a semiconductor die assembly may have a greater lateral density than electrical-interconnect pillars in the same assembly.", "As another example, different regions of a semiconductor die may have different needs for electrical and/or thermal interconnection with a neighboring semiconductor die, thus calling for different arrays of pillars and/or different portions of a single array of pillars to have different lateral densities to meet these needs.", "Other examples of reasons for using differing lateral densities of pillars in the same semiconductor die assembly are also possible.", "Semiconductor die assemblies and related devices, systems, and methods in accordance with embodiments of the present technology can have features that facilitate achieving relatively uniform pillar heights among and between arrays of pillars having different lateral densities (e.g., different lateral spacing between pillars in different regions).", "In at least some embodiments, different target widths for pillars in these arrays are selected to at least partially offset an effect of the differing lateral densities of the pillars on a metal deposition rate for an electrochemical plating process used to form the pillars.", "In a particular embodiment, first pillars in an array of the first pillars have a different lateral density and a different average width than a lateral density and an average width of second pillars in an array of the second pillars within the same semiconductor die assembly.", "In addition or alternatively, dummy pillars can be interspersed among the first pillars and/or among the second pillars.", "The presence, size, lateral density, etc.", "of dummy pillars may supplement or take the place of differing pillar width in offsetting the effect of the differing lateral pillar densities on the metal deposition rate.", "Other advantages over conventional counterparts in addition to or instead of the foregoing advantages also may be present.", "Furthermore, as described below, semiconductor die assemblies and related devices, systems, and methods in accordance with embodiments of the present technology can have features in addition to or instead of features associated with use of different widths and/or dummy pillars to offset the effect of the differing lateral densities on a metal deposition rate.", "Specific details of semiconductor die assemblies and related devices, systems, and methods in accordance with several embodiments of the present technology are disclosed herein with reference to FIGS.", "1-14.Although these embodiments may be disclosed herein primarily or entirely in the context of pillars that electrically and thermally interconnect neighboring semiconductor dies in a stack, other suitable contexts are within the scope of the present technology.", "For example, suitable features disclosed in the context of electrical-interconnect pillars and/or in the context of thermal pillars can be implemented in the context of arrays of optical-interconnect pillars or in the context of arrays of structural pillars.", "Furthermore, it should be understood that suitable features of the present technology disclosed in the context of array-to-array variation in lateral pillar density can be implemented in the context of within-array variation in lateral pillar density.", "Also, suitable features of the present technology disclosed in the context of relatively tall pillars at one side of a die can be implemented in the context of relatively short pillars (e.g., bond pads, under-bump metallization, etc.)", "at an opposite side of the die.", "In general, it should be understood that various other devices, systems, and methods in addition to those disclosed herein may be within the scope of the present technology.", "For example, devices, systems, and methods in accordance with embodiments of the present technology can have different and/or additional configurations, components, or procedures than those disclosed herein.", "Moreover, a person of ordinary skill in the art will understand that devices, systems, and methods in accordance with embodiments of the present technology can be without configurations, components, or procedures disclosed herein without deviating from the present technology.", "FIG.", "1 is a side view of a semiconductor die assembly 100 in accordance with an embodiment of the present technology, and FIG.", "2 is an enlarged view of a portion of FIG.", "1.With reference to FIGS.", "1 and 2 together, the semiconductor die assembly 100 can include a first semiconductor die 102 and a second semiconductor die 104 spaced apart from one another.", "In a finished package, the first and second semiconductor dies 102, 104 can be encapsulated alone or with other semiconductor dies.", "In the illustrated orientation, the first and second semiconductor dies 102, 104 each have an upper major surface 106 and an opposite lower major surface 108.The first semiconductor die 102 can include laterally spaced apart electrical-interconnect pillars 110 extending heightwise toward the second semiconductor die 104.The second semiconductor die 104 can include laterally spaced apart bond pads 112 aligned with the electrical-interconnect pillars 110.For clarity of illustration, only one row of the electrical-interconnect pillars 110 and only one corresponding row of the bond pads 112 are shown in FIGS.", "1 and 2.The electrical-interconnect pillars 110 and the bond pads 112 can be electrically connected to internal circuity (not shown) of the first and second semiconductor dies 102, 104, respectively.", "Individual pairs of one of the electrical-interconnect pillars 110 and a corresponding one of the bond pads 112 can be configured to form an electrical connection between the internal circuitry of the first and second semiconductor dies 102, 104.Between an individual electrical-interconnect pillar 110 and an individual bond pad 112, the semiconductor die assembly 100 can include a volume of barrier material 114 and a volume of solder 116 that together for a complete electrical connection.", "In the illustrated embodiment, the semiconductor die assembly 100 includes only two semiconductor dies.", "In other embodiments, a counterpart of the semiconductor die assembly 100 can include more than two semiconductor dies.", "For example, in such an embodiment, a counterpart of the first semiconductor die 102 can include bond pads at its lower major surface for electrical connection with additional underlying semiconductor dies.", "Similarly, a counterpart of the second semiconductor die 104 can include electrical-interconnect pillars at its upper major surface for electrical connection with additional overlying semiconductor dies.", "Furthermore, counterparts of the components described above for forming electrical interconnections between internal circuitry of the first and second semiconductor dies 102, 104 can instead form electrical connections to and/or between the underlying and overlying semiconductor dies.", "FIG.", "3 is an enlarged cross-sectional view of a portion of the semiconductor die assembly 100 corresponding to the portion shown in FIG.", "2 taken along the line 3-3 in FIG.", "2.As shown in FIG.", "3, the electrical-interconnect pillars 110 can be arranged in a first array 118 at a first region 120 of the upper major surface 106 of the first semiconductor die 102.The first semiconductor die 102 can further include thermal pillars 122 arranged in a second array 124 at a non-overlapping second region 126 of its upper major surface 106.Like the electrical-interconnect pillars 110, the thermal pillars 122 can extend heightwise toward the second semiconductor die 104 (FIG.", "1).", "The thermal pillars 122 can be configured to conduct heat rather than electricity between the first and second semiconductor dies 102, 104.Accordingly, the thermal pillars 122 can be electrically insulated from internal circuitry of one or both of the first and second semiconductor dies 102, 104.In the illustrated embodiment, the lateral density of the electrical-interconnect pillars 110 is lower than the lateral density of the thermal pillars 122 (e.g., by at least 5% or by at least 10%), and the minimum lateral spacing between the electrical-interconnect pillars 110 is greater than the minimum lateral spacing between the thermal pillars 122 (e.g., by at least 5% or by at least 10%).", "In other embodiments, the lateral density of counterparts of the electrical-interconnect pillars 110 can be higher than the lateral density of counterparts of the thermal pillars 122, and the minimum lateral spacing between the counterparts of the electrical-interconnect pillars 110 can be less than the minimum lateral spacing between the counterparts of the thermal pillars 122.FIG.", "4 is a further enlarged top plan view of one of the electrical-interconnect pillars 110 and one of the thermal pillars 122 in isolation.", "As shown in FIG.", "4, the width W1 of the illustrated electrical-interconnect pillar 110 is greater than the width W2 of the illustrated thermal pillar 122 by a difference D1.Correspondingly, an average width of the electrical-interconnect pillars 110 throughout the first array 118 can be greater than an average width of the thermal pillars 122 throughout the second array 124 (e.g., by at least 2% or by at least 5%).", "This difference in average width can be imparted to the electrical-interconnect pillars 110 and to the thermal pillars 122 by design.", "For example, for an electrochemical plating process having a metal deposition rate directly or inversely proportional to both lateral pillar density and pillar width, decreasing the width of the thermal pillars 122 relative to the width of the electrical-interconnect pillars 110 can at least partially offset a difference in final plated height due to the higher lateral pillar density of the thermal pillars 122.In this way, even though the respective lateral densities of the electrical-interconnect pillars 110 in the first array 118 and the thermal pillars 122 in the second array 124 are significantly different, the final plated height of both the electrical-interconnect pillars 110 and of the thermal pillars 122 can be approximately the same.", "Similarly, the bond pads 112 (not shown in FIGS.", "3 and 4) corresponding to the electrical-interconnect pillars 110 in the first array 118 and the thermal pillars 122 in the second array 124 can have different average widths and similar final plated heights.", "FIG.", "5 is a cross-sectional view similar to FIG.", "3 showing a portion of a semiconductor die assembly 200 in accordance with another embodiment of the present technology.", "As shown in FIG.", "5, the semiconductor die assembly 200 can include electrical-interconnect pillars 202 arranged in a first array 204, and thermal pillars 206 arranged in a second array 208.FIG.", "6 is an enlarged top plan view of one of the electrical-interconnect pillars 202 and one of the thermal pillars 206 in isolation.", "As shown in FIG.", "6, a width W3 of the illustrated electrical-interconnect pillar 202 is less than a width W4 of the illustrated thermal pillar 122 by a difference D2.Correspondingly, an average width of the electrical-interconnect pillars 202 throughout the first array 204 can be less than an average width of the thermal pillars 206 throughout the second array 208 (e.g., by at least 2% or by at least 5%).", "Again, the difference in average width can be imparted to the electrical-interconnect pillars 202 and to the thermal pillars 206 by design.", "For example, for an electrochemical plating process having a metal deposition rate directly proportional to lateral pillar density and inversely proportional to pillar width or for an electrochemical plating process having a metal deposition rate inversely proportional to lateral pillar density and directly proportional to pillar width, increasing the width of the thermal pillars 206 relative to the width of the electrical-interconnect pillars 202 can at least partially offset a difference in final plated height due to the difference in lateral pillar densities.", "FIG.", "7 is a cross-sectional view similar to FIG.", "3 showing a portion of a semiconductor die assembly 300 in accordance with another embodiment of the present technology.", "As shown in FIG.", "7, the semiconductor die assembly 300 can include electrical-interconnect pillars 302 arranged in a first array 304, and thermal pillars 306 arranged in a second array 308.The semiconductor die assembly 300 can further include dummy pillars 310 interspersed among the electrical-interconnect pillars 302 within the first array 304.The dummy pillars 310 can be configured to be plated with metal by an electrochemical plating process that also plates metal onto the electrical-interconnect pillars 302.Similar to the differences in average width discussed above with reference to FIGS.", "3-7, the dummy pillars 310 can at least partially offset a difference in final plated height that would otherwise occur due to the difference between the lateral density of the electrical-interconnect pillars 302 relative to the lateral density of the thermal pillars 306.In the illustrated embodiment, the dummy pillars 310 are present within the first array 304 only.", "This arrangement can be useful when an electrochemical plating process used to form the electrical-interconnect pillars 302 has a metal deposition rate directly or inversely proportional to both lateral pillar density and the presence of the dummy pillars 310.In other embodiments, additional dummy pillars can be interspersed among counterparts of the thermal pillars 306 at a lesser density or coverage than the density or coverage of the dummy pillars 310 within the first array 304.In still other embodiments dummy pillars can be present within a counterpart of the second array 308 only or present within a counterpart of the second array 308 at a greater density or coverage than the density or coverage of dummy pillars within a counterpart of the first array 304.This arrangement can be useful when an electrochemical plating process used to form electrical-interconnect pillars and thermal pillars has a metal deposition rate directly proportional to lateral pillar density and inversely proportional to the presence of dummy pillars or inversely proportional to lateral pillar density and directly proportional to the presence of dummy pillars.", "With reference again to FIG.", "7, the dummy pillars 310 can be designed into the semiconductor die assembly 300 instead of or in addition to a difference between the average width of the electrical-interconnect pillars 302 and the average width of the thermal pillars 306.In some cases, it may be undesirable for the average width of the electrical-interconnect pillars 302 and the average width of the thermal pillars 306 to be different.", "In these cases, the dummy pillars 310 can be designed into the semiconductor die assembly 300 instead of such a difference in average pillar width.", "Thus, even though the respective lateral densities of the electrical-interconnect pillars 302 in the first array 304 and the thermal pillars 306 in the second array 308 are significantly different, and even though the average width of the electrical-interconnect pillars 302 and the average width of the thermal pillars 306 are approximately the same (e.g., differing by at most 3%), the final plated height of both the electrical-interconnect pillars 302 and the thermal pillars 306 can be approximately the same due to at least partially to the presence of the dummy pillars 310.The dummy pillars 310 can have various suitable arrangements, shapes, sizes, etc.", "For example, FIG.", "8 is an enlarged top plan view of a cluster 312 that includes one of the electrical-interconnect pillars 302 and several of the dummy pillars 310 of the semiconductor die assembly 300.FIG.", "9 is a cross-sectional view of the cluster 312 taken along the line 9-9 in FIG.", "8.With reference to FIGS.", "7-9 together, the dummy pillars 310 of the cluster 312 can be positioned at laterally spaced apart points along a path that extends around the associated electrical-interconnect pillar 302.In the illustrated embodiment, the path is square.", "In other embodiments, the path can be circular or another suitable shape.", "In at least some embodiments, the dummy pillars 310 are narrower than the electrical-interconnect pillars 302.Furthermore, as shown in FIG.", "9, the dummy pillars 310 of the cluster 312 can be recessed relative to the associated electrical-interconnect pillar 302.For example, an average height of the dummy pillars 310 throughout the first array 304 can be at least 10% less than an average height of the electrical-interconnect pillars 302 throughout the first array 304.The width of the dummy pillars 310 relative to the width of the electrical-interconnect pillars 302 can be selected to cause the dummy pillars 310 to be significantly shorter than the electrical-interconnect pillars 302.Thus, when the electrical-interconnect pillars 302 are electrically connected to a planar region of an overlying semiconductor die, the dummy pillars 310 can remain spaced apart from the overlying semiconductor die.", "In this way, the dummy pillars 310 can advantageously remain electrically isolated from the from the overlying semiconductor die.", "FIG.", "10 is an enlarged top plan view of a cluster 400 of pillars of a semiconductor die assembly in accordance with another embodiment of the present technology.", "The cluster 400 can include an electrical-interconnect pillar 402, first dummy pillars 404 individually positioned at laterally spaced apart points along a path that extends around the electrical-interconnect pillar 402, and second dummy pillars 406 individually positioned at laterally spaced apart points along a path that extends around the first dummy pillars 404.The average width of the first dummy pillars 404 can be less than the width of the electrical-interconnect pillar 402, and the average width of the second dummy pillars 406 can be less than the average width of the first dummy pillars 404.FIG.", "11 is a cross-sectional view of the cluster 400 taken along the line 11-11 in FIG.", "10.As shown in FIG.", "11, the average height of the first dummy pillars 404 can be less than the height of the electrical-interconnect pillar 402, and the average height of the second dummy pillars 406 can be less than the average height of the first dummy pillars 404.In other embodiments, the average width of counterparts of the second dummy pillars 406 can be greater than or equal to the average width of counterparts of the first dummy pillars 404.In addition or alternatively, the average height of counterparts of the second dummy pillars 406 can be greater than or equal to the average height of counterparts of the first dummy pillars 404.FIG.", "12 is a flow chart illustrating a method 500 for making a semiconductor die assembly in accordance with an embodiment of the present technology.", "The method 500 can include forming patterns for arrays of pillars with different lateral densities on a die surface, such as by photolithography (block 502).", "Next, the method 500 can include electrochemically plating metal (e.g., copper) by an electrochemical plating process to form the pillars of the different arrays simultaneously (block 504).", "During the electrochemical plating process, a difference between the lateral density of first pillars within a first one of the arrays and the lateral density of second pillars within a second one of the arrays can have a first effect on relative metal deposition rates of the electrochemical plating process.", "Without mitigation, the first effect can cause a difference between an average plated height of the first pillars after the electrochemical plating process and an average plated height of the second pillars after the electrochemical plating process.", "In addition or alternatively, the first effect can cause a difference between a maximum plated height of any of the first and second pillars after the electrochemical plating process and a minimum plated height of any of the first and second pillars after the electrochemical plating process.", "The first and second pillars can have different average widths and/or the first and arrays can have different densities or coverages of dummy pillars, with such differences having a second effect that at least partially offsets the difference caused by the first effect.", "For example, the second effect can reduce a difference between the average plated height of the first pillars after the electrochemical plating process and the average plated height of the second pillars after the electrochemical plating process that would otherwise be caused by the first effect by at least 50%.", "In addition or alternatively, the second effect can reduce a difference between the maximum plated height of any of the first and second pillars after the electrochemical plating process and the minimum plated height of any of the first and second pillars after the electrochemical plating process by at least 5%.", "After the electrochemical plating of the first and second pillars is complete, the method 500 can include electrically coupling a first semiconductor die including the first and second pillars to a second semiconductor die via one of the array of the first pillars and the array of the second pillars (block 506).", "The method 500 can further include thermally coupling the first semiconductor die and the second semiconductor die via the other one of the array of the first pillars and the array of the second pillars (block 508).", "FIG.", "13 is a flow chart illustrating a method 600 for designing arrays of electrochemically plated pillars in a semiconductor die assembly in accordance with an embodiment of the present technology.", "The method 600 can include determining the lateral densities of first and second pillars to be formed at different regions of a semiconductor die (block 602).", "Based at least partially on the determined lateral pillar densities, the method 600 can include selecting a target width for the first pillars (block 604) and selecting a target width for the second pillars (block 606).", "The target widths for the first and second pillars can be selected to be different (e.g., by at least 2% or by at least 5%), with the difference in target widths at least partially offsetting a difference in expected plated height caused by the difference in lateral pillar densities.", "The method 600 can further include selecting a distribution of dummy pillars (block 608) with greater density or coverage of the dummy pillars among the first pillars than among the second pillars.", "Like the target pillar widths, the distribution of dummy pillars can be selected to at least partially offset the difference in expected plated height caused by the difference in lateral pillar densities.", "The method 600 can then include patterning a photomask (block 610) that can be used to form the first and second pillars by photolithography.", "Any one of the semiconductor die assemblies described above with reference to FIGS.", "1-13 can be incorporated into any of a myriad of larger and/or more complex systems, a representative example of which is system 700 shown schematically in FIG.", "14.The system 700 can include a semiconductor die assembly 702, a power source 704, a driver 706, a processor 708, and/or other subsystems or components 710.The semiconductor die assembly 702 can include features generally similar to those of the semiconductor die assemblies described above, and can therefore include different widths and/or dummy pillars that offset the effect of differing lateral densities on metal deposition rate.", "The resulting system 700 can perform any of a wide variety of functions, such as memory storage, data processing, and/or other suitable functions.", "Accordingly, representative systems 700 can include, without limitation, hand-held devices (e.g., mobile phones, tablets, digital readers, and digital audio players), computers, and appliances.", "Components of the system 700 may be housed in a single unit or distributed over multiple, interconnected units (e.g., through a communications network).", "The components of the system 700 can also include remote devices and any of a wide variety of computer readable media.", "This disclosure is not intended to be exhaustive or to limit the present technology to the precise forms disclosed herein.", "Although specific embodiments are disclosed herein for illustrative purposes, various equivalent modifications are possible without deviating from the present technology, as those of ordinary skill in the relevant art will recognize.", "In some cases, well-known structures and functions have not been shown and/or described in detail to avoid unnecessarily obscuring the description of the embodiments of the present technology.", "Although steps of methods may be presented herein in a particular order, in alternative embodiments the steps may have another suitable order.", "Similarly, certain aspects of the present technology disclosed in the context of particular embodiments can be combined or eliminated in other embodiments.", "Furthermore, while advantages associated with certain embodiments may have been disclosed in the context of those embodiments, other embodiments may also exhibit such advantages, and not all embodiments need necessarily exhibit such advantages or other advantages disclosed herein to fall within the scope of the present technology.", "Throughout this disclosure, the singular terms “a,” “an,” and “the” include plural referents unless the context clearly indicates otherwise.", "Similarly, unless the word “or” is expressly limited to mean only a single item exclusive from the other items in reference to a list of two or more items, then the use of “or” in such a list is to be interpreted as including (a) any single item in the list, (b) all of the items in the list, or (c) any combination of the items in the list.", "Additionally, the terms “comprising” and the like may be used herein to mean including at least the recited feature(s) such that any greater number of the same feature(s) and/or one or more additional types of features are not precluded.", "Directional terms, such as “upper,” “lower,” “front,” “back,” “vertical,” and “horizontal,” may be used herein to express and clarify the relationship between various elements.", "It should be understood that such terms do not denote absolute orientation.", "Reference herein to “one embodiment,” “an embodiment,” or similar formulations means that a particular feature, structure, operation, or characteristic described in connection with the embodiment can be included in at least one embodiment of the present technology.", "Thus, the appearances of such phrases or formulations herein are not all referring to the same embodiment.", "Furthermore, various particular features, structures, operations, or characteristics may be combined in any suitable manner in one or more embodiments of the present technology." ] ]
Patent_15872845
[ [ "UV Plastic Object Protection System", "A UV plastic object protection system for protecting a plastic object and any contents of the plastic object from ultraviolet light.", "The UV plastic object protection system generally includes a plastic material mixed with a UV reflective material to reflect UV light to protect the plastic object and any contents within the plastic object.", "The UV reflective material may alternatively be attached to the exterior of the plastic object via a host material such as paint, dye, ink or adhesive label." ], [ "1.A UV plastic object protection system, comprising: a plastic object comprising an exterior and an interior, wherein the plastic object is comprised of a plastic material, wherein the plastic object is adapted to store a material within the interior of the plastic object; and a UV reflective material attached to the plastic object, wherein the UV reflective material is adapted to reflect UV light away from the plastic object; and wherein the UV reflective material is adapted to protect the material within the interior of the plastic object from exposure to UV light when the plastic object is exposed to UV light.", "2.The UV plastic object protection system of claim 1, wherein the UV reflective material is attached to the exterior of the plastic object.", "3.The UV plastic object protection system of claim 2, wherein the UV reflective material is adapted to protect the plastic object from exposure to UV light.", "4.The UV plastic object protection system of claim 2, wherein the UV reflective material is mixed with an attaching material for attachment to the exterior of the plastic object.", "5.The UV plastic object protection system of claim 4, wherein the attaching material is selected from the group consisting of glue, paint, ink, dye, resin, lacquer, or varnish.", "6.The UV plastic object protection system of claim 4, wherein the UV reflective material is printed on the exterior of the plastic object.", "7.The UV plastic object protection system of claim 4, wherein the UV reflective material is painted on the exterior of the plastic object.", "8.The UV plastic object protection system of claim 4, wherein the UV reflective material is attached to a substrate.", "9.The UV plastic object protection system of claim 8, wherein the substrate is attached to the exterior of the plastic object.", "10.The UV plastic object protection system of claim 3, wherein the UV reflective material is comprised of barium sulfate.", "11.The UV plastic object protection system of claim 1, wherein the UV reflective material is attached to the interior of the plastic object.", "12.The UV plastic object protection system of claim 1, further comprising an edible material positioned within the interior of the plastic object.", "13.The UV plastic object protection system of claim 12, wherein the edible material is comprised of a liquid.", "14.The UV plastic object protection system of claim 13, wherein the edible material is comprised of water.", "15.The UV plastic object protection system of claim 1, wherein the plastic object is comprised of a container.", "16.The UV plastic object protection system of claim 15, wherein the plastic object is comprised of a bottle.", "17.The UV plastic object protection system of claim 1, wherein the UV reflective material is comprised of barium sulfate.", "18.The UV plastic object protection system of claim 1, wherein the UV reflective material is attached to a koozie, wherein the koozie removably surrounds the plastic object, wherein the UV reflective material is attached to an exterior surface of the koozie.", "19.A UV plastic object protection system, comprising: a plastic object comprising an exterior, wherein the plastic object is comprised of a plastic material; a UV reflective material attached to the exterior of the plastic object, wherein the UV reflective material is adapted to reflect UV light away from the plastic object; and wherein the UV reflective material is adapted to protect the exterior of the plastic object from exposure to UV light when the plastic object is exposed to UV light.", "20.The UV plastic object protection system of claim 19, wherein the plastic object comprises a waterfowl decoy." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> BRIEF SUMMARY OF THE INVENTION <EOH>The invention generally relates to an ultraviolet light protection system which includes a plastic material mixed with a UV reflective material to reflect UV light to protect the plastic object and any contents within the plastic object.", "The UV reflective material may alternatively be attached to the exterior of the plastic object via a host material such as paint, dye, ink or adhesive label.", "There has thus been outlined, rather broadly, some of the features of the invention in order that the detailed description thereof may be better understood, and in order that the present contribution to the art may be better appreciated.", "There are additional features of the invention that will be described hereinafter and that will form the subject matter of the claims appended hereto.", "In this respect, before explaining at least one embodiment of the invention in detail, it is to be understood that the invention is not limited in its application to the details of construction or to the arrangements of the components set forth in the following description or illustrated in the drawings.", "The invention is capable of other embodiments and of being practiced and carried out in various ways.", "Also, it is to be understood that the phraseology and terminology employed herein are for the purpose of the description and should not be regarded as limiting." ], [ "CROSS REFERENCE TO RELATED APPLICATIONS The present application is a continuation-in-part of U.S. application Ser.", "No.", "14/926,413 filed on Oct. 29, 2015 (Docket No.", "REEL-020), which claims priority to U.S.", "Provisional Application No.", "62/074,258 filed Nov. 3, 2014 (Docket No.", "REEL-018).", "Each of the aforementioned patent applications, and any applications related thereto, is herein incorporated by reference in their entirety.", "STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT Not applicable to this application.", "BACKGROUND OF THE INVENTION Field of the Invention The present invention relates generally to an ultraviolet light protection system and more specifically it relates to a UV plastic object protection system for protecting a plastic object and any contents of the plastic object from ultraviolet light.", "Description of the Related Art Any discussion of the related art throughout the specification should in no way be considered as an admission that such related art is widely known or forms part of common general knowledge in the field.", "Ultraviolet (UV) light is destructive to plastic, objects constructed of plastic and also the contents of a plastic object.", "For example, beverages such as pop or water contained within a plastic container are subject to damage and temperature increase by UV light passing through the plastic container (e.g.", "bottle).", "Plastic containers (e.g.", "plastic bottles) that include bisphenol A (BPA) may leach the BPA into the liquid within the plastic container when exposed to UV light.", "Furthermore, plastic bottles that do not include BPA may also leach BPA-like chemicals or synthetic estrogens into the liquids when exposed to UV light.", "Because of the inherent problems with the related art, there is a need for a new and improved UV plastic object protection system for protecting a plastic object and any contents of the plastic object from ultraviolet light.", "BRIEF SUMMARY OF THE INVENTION The invention generally relates to an ultraviolet light protection system which includes a plastic material mixed with a UV reflective material to reflect UV light to protect the plastic object and any contents within the plastic object.", "The UV reflective material may alternatively be attached to the exterior of the plastic object via a host material such as paint, dye, ink or adhesive label.", "There has thus been outlined, rather broadly, some of the features of the invention in order that the detailed description thereof may be better understood, and in order that the present contribution to the art may be better appreciated.", "There are additional features of the invention that will be described hereinafter and that will form the subject matter of the claims appended hereto.", "In this respect, before explaining at least one embodiment of the invention in detail, it is to be understood that the invention is not limited in its application to the details of construction or to the arrangements of the components set forth in the following description or illustrated in the drawings.", "The invention is capable of other embodiments and of being practiced and carried out in various ways.", "Also, it is to be understood that the phraseology and terminology employed herein are for the purpose of the description and should not be regarded as limiting.", "BRIEF DESCRIPTION OF THE DRAWINGS Various other objects, features and attendant advantages of the present invention will become fully appreciated as the same becomes better understood when considered in conjunction with the accompanying drawings, in which like reference characters designate the same or similar parts throughout the several views, and wherein: FIG.", "1 is a flowchart illustrating the process of making a plastic object with the UV reflective material integrated into the plastic.", "FIG.", "2 is a side view of a plastic container with the UV reflective material integrated into the plastic.", "FIG.", "3 is a cross sectional view taken along line 3-3 of FIG.", "2 illustrating the interior of the plastic container protected by the plastic container.", "FIG.", "4 is a side view of an alternative embodiment of the present invention having a UV reflective layer applied to the outside of the plastic container.", "FIG.", "5 is a cross sectional view taken along line 5-5 of FIG.", "4.FIG.", "6 is a cutaway view of a layer of substrate having an adhesive for attachment to a plastic object and with a UV reflective layer attached to the side of the substrate opposite of the adhesive.", "FIG.", "7 is a side view of another alternative embodiment with the UV reflective material attached to the exterior surface of a koozie that removably surrounds the plastic object.", "FIG.", "8 is an upper perspective view of another alternative embodiment of the present invention comprised of a cooler.", "DETAILED DESCRIPTION OF THE INVENTION A. Overview.", "Turning now descriptively to the drawings, in which similar reference characters denote similar elements throughout the several views, FIGS.", "1 through 8 illustrate a UV plastic object protection system, which comprises a plastic material mixed with a UV reflective material to reflect ultraviolet (UV) light to protect the plastic object 20 and any contents 12 within the plastic object 20.UV light is electromagnetic radiation with a wavelength shorter than that of visible light but longer than X-rays (from 400 nm to 10 nm in wavelength).", "UV light is typically not visible to humans, but can be seen by some children and young adults.", "The UV reflective material 30 may alternatively be attached to the exterior of the plastic object 20 via a host material such as paint, dye, ink or adhesive label.", "The UV reflective material 30 protects the plastic object 20 from damage, keeps the temperature of the plastic lower and also keeps the contents of the plastic object 20 (e.g.", "edible material 12 such as pop or water) at a lower temperature when exposed to UV light from the sun.", "B.", "Plastic Material.", "The plastic material used for the present invention may be comprised of any well-known plastic material.", "The plastic material may be synthetic or semi-synthetic organic solids that are moldable.", "In a preferred embodiment of the present invention, the plastic material is derived from petrochemicals.", "The plastic material is typically initially provided in a particulate or pellet form which is then combined with the UV reflective material 30 prior to or after melting the plastic material thereby allowing the UV reflective material 30 to be thoroughly mixed with the plastic material prior to forming the plastic object 20.C.", "UV Reflective Material.", "The UV reflective material 30 is added to the plastic material to provide the composition with desired UV reflective properties.", "The UV reflective material 30 forms a UV light protective layer around at least a portion of the plastic object 20 such as the sidewall.", "Only a portion of the plastic object 20 may include the UV reflective material 30 such as the sidewall 24.It is emphasized that the UV reflective material 30 reflects ultraviolet (UV) light and does not absorb the UV light.", "The UV reflective material 30 may be a single substance or a combination of substances and may be formed in various colors as appreciated similar to the base substance.", "The UV reflective material 30 is preferably comprised of a nontoxic, biodegradable, edible, odorless substance that is able to mix with an oil-based plastic to form the composition.", "In the preferred embodiment, the UV reflective material 30 is comprised of barium sulfate or similar substance.", "The barium sulfate is preferably pharmaceutical grade and is further preferably in powder form (e.g.", "crystalline solid) prior to mixing with the plastic material.", "The amount of UV reflective material 30 added to the plastic material depends upon the amount of UV light desired to be reflected by the plastic object 20.An increased percentage of UV reflective material 30 is used where the plastic container 20 will be exposed to an increased level of UV light or where the contents of the plastic container 20 require increased protection from UV light.", "D. Plastic Objects.", "The present invention may be utilized for any plastic object 20 that is exposed to UV light from the sun.", "The present invention may be utilized to manufacture various types of plastic objects 20 such as, but not limited to, bottles, liquid containers, pitchers, baby bottles, juice bottles, food containers, coolers, koozies, PVC siding, window frames, door frames, pipes and gutters.", "In some embodiments, the plastic objects 20 may comprise hunting decoys which are typically used while hunting to attract various game being hunted.", "By way of example and without limitation, the plastic objects 20 could comprise water-fowl decoys.", "The present invention is particularly useful for protecting edible material 12 such as liquids (e.g.", "pop, water) and the like from exposure to UV light and leaked chemicals from the plastic container 20 when the plastic container 20 is exposed to UV light.", "FIG.", "8 illustrates the plastic container 20 being comprised of an exemplary cooler having a sidewall 24 and a floor 28 defining the interior space 21 along with a lid 22 pivotally attached to selectively enclose the interior space 21.The sidewall 24 and the lid 22 includes the UV reflective material 30 embedded within the plastic material used to construct the plastic container 20 constructed as a cooler.", "The UV reflective material 30 in the plastic material used for the cooler keeps the interior space 21 and food products cooler by reflecting the UV light.", "E. First Embodiment—UV Reflective Material Integrated with Plastic Object.", "In the first embodiment shown in FIGS.", "1 through 3 of the drawings, the plastic material is combined with the UV reflective material then heated into a liquid composition.", "The liquid plastic composition and UV reflective material is mixed thoroughly to ensure that the UV reflective material is adequately present throughout the plastic material.", "The liquid plastic is then used to construct a plastic object 20 such as a plastic container 20 via injection molding, rotational molding or other plastic molding process.", "The formed plastic object 20 (and any interior 21 contents) is protected from UV light by the UV reflective material within the plastic which reflects the UV light.", "FIGS.", "2 and 3 illustrate a plastic container 20 with the UV reflective material integrated into the plastic that forms the plastic container 20.The plastic container 20 may have various shapes and sizes suitable for containing a volume of edible material 12 such as pop, water, juice, milk and the like.", "For example, the plastic container 20 may have a bottle shape that has a sidewall 24, a neck 26, a cap 22 removably attached to the neck 26 and a bottom end 28 defining the interior 21 of the plastic container 20.When the UV light from the sun reaches the surface and interior 21 of the plastic container 20, the UV light is reflected away thereby reducing the amount of UV light that enters the interior 21 of the plastic container 20 along with reducing the temperature of the plastic container 20 and the edible material 12 within the plastic container 20.F.", "Second Embodiment—UV Reflective Material Applied to Surface of Plastic Object.", "In a second embodiment of the present invention as illustrated in FIGS.", "4 and 5 of the drawings, the UV reflective material 30 is applied and attached to the surface (exterior or interior 21) of the plastic object 20.It is preferable that the UV reflective material 30 is applied and attached to the exterior of the plastic object 20 to reduce the amount of UV light that penetrates the plastic which can result in the release of harmful chemicals into the edible material 12.The UV reflective material 30 may be mixed with various liquid based attachment materials for attachment to the exterior of the plastic object 20 such as paint (e.g.", "oil-based pain), ink, dye, glue, resin, lacquer, varnish and the like which is then applied to the exterior of the plastic object 20.Various processes for applying the UV reflective material 30 with the liquid based material may be used such as printing, painting and the like.", "G. Third Embodiment—UV Reflective Material Applied to Substrate.", "FIG.", "6 illustrates a third embodiment of the present invention where the UV reflective material 30 is applied and attached to a surface of a substrate 32, wherein the substrate 32 is then attached to the exterior of the plastic object 20.The substrate 32 is preferably a flexible film and may be comprised of a transparent or semi-transparent material.", "It is preferable that the substrate 32 include an adhesive 34 on a side opposite of the UV reflective material 30 as shown in FIG.", "6.The UV reflective material 30 may be applied to the substrate 32 similar to the second embodiment via a paint, ink, dye, glue and the like.", "The substrate 32 with the UV reflective material 30 is then attached to the exterior of the plastic object 20 (e.g.", "the sidewall 24 of the plastic container 20) thereby protecting the plastic object 20.H.", "Fourth Embodiment—UV Reflective Material Applied to Exterior of Holder.", "In a fourth embodiment not illustrated in the figures, the UV reflective material may be applied to the exterior of a holder such as a koozie 40 that removably surrounds a plastic container 20 thereby protecting the koozie 40 and the plastic container 20 from the UV light.", "The UV reflective material may be applied to the exterior of the koozie 40 via an integral process such as in the first embodiment of the present invention or applied to the exterior of the koozie 40 via the process illustrated in the second embodiment of the present invention.", "The koozie 40 is comprised of an insulated sleeve material that in addition insulates the plastic object 20 and the edible material 12 within the plastic object 20.Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.", "Although methods and materials similar to or equivalent to those described herein can be used in the practice or testing of the present invention, suitable methods and materials are described above.", "All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety to the extent allowed by applicable law and regulations.", "The present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof, and it is therefore desired that the present embodiment be considered in all respects as illustrative and not restrictive.", "Any headings utilized within the description are for convenience only and have no legal or limiting effect." ] ]
Patent_15872849
[ [ "Masking Open Space Noise Using Sound and Corresponding Visual", "Methods and apparatuses for addressing open space noise are disclosed.", "In one example, a method for masking open space noise includes outputting from a speaker a speaker sound corresponding to a flow of water, and displaying a water element system, the water element system generating a sound of flowing water." ], [ "1.A method for masking open space noise comprising: optimizing a nature sound signal to mask noise in an open space to generate an optimized nature sound signal; outputting the optimized nature sound signal from a plurality of speakers distributed in the open space; and displaying a nature visual matching the optimized nature sound signal on an electronic display screen located within the open space.", "2.The method of claim 1, wherein optimizing the nature sound signal to mask noise in the open space to generate the optimized nature sound signal comprises modifying a frequency characteristic of the nature sound signal.", "3.The method of claim 2, wherein modifying the frequency characteristic of the nature sound signal comprises increasing a frequency of the nature sound signal.", "4.The method of claim 3, wherein increasing the frequency of the nature sound signal comprises adding 2-4 dB per octave.", "5.The method of claim 1, wherein optimizing the nature sound signal to mask noise in the open space to generate the optimized nature sound signal comprises modifying a frequency characteristic of the nature sound signal to mask a higher frequency open space noise than a random noise.", "6.The method of claim 5, wherein the random noise comprises a pink noise.", "7.The method of claim 1, wherein the nature sound signal comprises a sound of flowing water.", "8.The method of claim 7, wherein the sound of flowing water comprises a recording of a natural flow of water or an electronically synthesized sound of flow of water.", "9.The method of claim 1, further comprising varying an output level of the optimized nature sound signal at a first speaker of the plurality of speakers relative to a second speaker of the plurality of speakers.", "10.The method of claim 9, wherein the output level of the optimized nature sound signal at the first speaker of the plurality of speakers relative to the second speaker of the plurality of speakers is varied dependent on a relative position of the first speaker and the second speaker to the electronic display screen.", "11.The method of claim 1, further comprising outputting from the plurality of speakers a noise masking sound comprising a pink noise.", "12.The method of claim 11, wherein the optimized nature sound signal is output at a sound level to mask the pink noise.", "13.The method of claim 1, wherein the optimized nature sound signal comprises sounds associated with a nature environment, the nature environment comprising a rainforest.", "14.The method of claim 1, wherein the nature visual comprises a flow of water and the optimized nature sound signal comprises a sound of flowing water.", "15.The method of claim 1, further comprising varying an output level of the optimized nature sound signal as a function of time.", "16.A system for masking open space noise comprising: a plurality of speakers distributed in an open space arranged to output an optimized nature sound signal to mask noise in the open space; and an electronic display screen displaying a nature visual matching the optimized nature sound signal arranged to reduce an adverse effect on a user hearing the optimized nature sound signal.", "17.The system of claim 16, wherein the optimized nature sound signal is a natural sound having a modified frequency characteristic to mask open space noise.", "18.The system of claim 17, wherein the modified frequency characteristic to mask open space noise comprises an increased frequency of 2-4 dB per octave.", "19.The system of claim 16, wherein the optimized nature sound signal comprises a sound of flowing water and the nature visual matching the optimized nature sound signal arranged to reduce an adverse effect on a user hearing the optimized nature sound signal comprises a flow of water.", "20.The system of claim 16, wherein the electronic display screen displaying the nature visual matching the optimized nature sound signal is arranged to be visible from any location within the open space." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Noise within an open space is problematic for people working within the open space.", "For example, many office buildings utilize a large open office area in which many employees work in cubicles with low cubicle walls or at workstations without any acoustical barriers.", "Open space noise, and in particular speech noise, is the top complaint of office workers about their offices.", "One reason for this is that speech enters readily into the brain's working memory and is therefore highly distracting.", "Even speech at very low levels can be highly distracting when ambient noise levels are low (as in the case of someone answering a telephone call in a library).", "Productivity losses due to speech noise have been shown in peer-reviewed laboratory studies to be as high as 41%.", "Office acoustic design has gotten very good at reducing ambient noise, but the quiet environments that have been created can cause speech noise to contrast strongly with the quiet.", "Even quiet offices, therefore, can create a level of speech intelligibility that is highly distracting.", "The intelligibility of speech can be measured using the Speech Transmission Index (STI).", "Another major issue with open offices relates to speech privacy.", "Workers in open offices often feel that their telephone calls or in-person conversations can be overheard.", "Speech privacy correlates directly to intelligibility.", "Lack of speech privacy creates measurable increases in stress and dissatisfaction and is one of the top complaints of workers about their office environments.", "Open office noise is typically described by workers as unpleasant and uncomfortable.", "Speech noise, printer noise, telephone ringer noise, and other distracting sounds increase discomfort.", "All of these can be summarized to three acoustic problems: (1) excessive and distracting levels of speech intelligibility, (2) lack of speech privacy, and (3) lack of acoustical comfort.", "All three of these problems are becoming increasingly important as office densification accelerates.", "The higher the utilization of office space, the more acoustical problems come to the fore.", "This discomfort can be measured using subjective questionnaires as well as objective measures, such as cortisol levels.", "In one type of prior art, the issues associated with office noise have been attacked by facilities professionals.", "Noise absorbing ceiling tiles, carpeting, screens, furniture, and so on, have become the standard and office noise has been substantially decreased.", "Reducing the noise levels does not, however, directly solve the three problems outlined above, as they relate to the intelligibility of speech.", "Speech intelligibility can be unaffected, or even increased, by the noise reduction measures of facilities professionals.", "Another type of prior art is injecting a pink noise or filtered pink noise (herein referred to simply as “pink noise”) into the open office.", "Pink noise is effective in reducing speech intelligibility, increasing speech privacy, and increasing acoustical comfort.", "However, listeners complain that pink noise sounds like an airplane environment, or complain that the constant air conditioning like sound of the pink noise becomes fatiguing over time.", "As a result, improved methods and apparatuses for addressing open space noise are needed." ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>The present invention will be readily understood by the following detailed description in conjunction with the accompanying drawings, wherein like reference numerals designate like structural elements.", "FIG.", "1 illustrates a system and method for masking open space noise in one example.", "FIG.", "2 illustrates a system and method for masking open space noise in a further example.", "FIG.", "3 illustrates a system for outputting a sound of flowing water from the speaker shown in FIG.", "1 in one example.", "FIG.", "4 illustrates a system for outputting a sound of flowing water and a noise from the speaker shown in FIG.", "2 in one example.", "FIG.", "5 illustrates placement of the speaker and the water element system shown in FIG.", "1 or FIG.", "2 in an open space in one example.", "FIG.", "6 illustrates placement of the speaker and the water element system shown in FIG.", "1 or FIG.", "2 in an open space in a further example.", "FIG.", "7 is a flow diagram illustrating masking open space noise in one example.", "FIG.", "8 is a flow diagram illustrating masking open space noise in one example.", "FIG.", "9 is a flow diagram illustrating masking open space noise in one example.", "FIG.", "10 illustrates placement of the speaker shown in FIG.", "1 in one example.", "FIG.", "11 illustrates the water element system shown in FIG.", "1 in one example.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATION This application is a divisional of co-pending U.S. Utility patent application Ser.", "No.", "15/233,511, filed Aug. 10, 2016, titled “Masking Open Space Noise Using Sound and Corresponding Visual,” which is a continuation of U.S. Utility Pat.", "No.", "9,445,190, issued Sep. 12, 2016, and titled “Masking Open Space Noise Using Sound and Corresponding Visual,” the disclosures of each which are incorporated herein by reference in their entireties.", "BACKGROUND OF THE INVENTION Noise within an open space is problematic for people working within the open space.", "For example, many office buildings utilize a large open office area in which many employees work in cubicles with low cubicle walls or at workstations without any acoustical barriers.", "Open space noise, and in particular speech noise, is the top complaint of office workers about their offices.", "One reason for this is that speech enters readily into the brain's working memory and is therefore highly distracting.", "Even speech at very low levels can be highly distracting when ambient noise levels are low (as in the case of someone answering a telephone call in a library).", "Productivity losses due to speech noise have been shown in peer-reviewed laboratory studies to be as high as 41%.", "Office acoustic design has gotten very good at reducing ambient noise, but the quiet environments that have been created can cause speech noise to contrast strongly with the quiet.", "Even quiet offices, therefore, can create a level of speech intelligibility that is highly distracting.", "The intelligibility of speech can be measured using the Speech Transmission Index (STI).", "Another major issue with open offices relates to speech privacy.", "Workers in open offices often feel that their telephone calls or in-person conversations can be overheard.", "Speech privacy correlates directly to intelligibility.", "Lack of speech privacy creates measurable increases in stress and dissatisfaction and is one of the top complaints of workers about their office environments.", "Open office noise is typically described by workers as unpleasant and uncomfortable.", "Speech noise, printer noise, telephone ringer noise, and other distracting sounds increase discomfort.", "All of these can be summarized to three acoustic problems: (1) excessive and distracting levels of speech intelligibility, (2) lack of speech privacy, and (3) lack of acoustical comfort.", "All three of these problems are becoming increasingly important as office densification accelerates.", "The higher the utilization of office space, the more acoustical problems come to the fore.", "This discomfort can be measured using subjective questionnaires as well as objective measures, such as cortisol levels.", "In one type of prior art, the issues associated with office noise have been attacked by facilities professionals.", "Noise absorbing ceiling tiles, carpeting, screens, furniture, and so on, have become the standard and office noise has been substantially decreased.", "Reducing the noise levels does not, however, directly solve the three problems outlined above, as they relate to the intelligibility of speech.", "Speech intelligibility can be unaffected, or even increased, by the noise reduction measures of facilities professionals.", "Another type of prior art is injecting a pink noise or filtered pink noise (herein referred to simply as “pink noise”) into the open office.", "Pink noise is effective in reducing speech intelligibility, increasing speech privacy, and increasing acoustical comfort.", "However, listeners complain that pink noise sounds like an airplane environment, or complain that the constant air conditioning like sound of the pink noise becomes fatiguing over time.", "As a result, improved methods and apparatuses for addressing open space noise are needed.", "BRIEF DESCRIPTION OF THE DRAWINGS The present invention will be readily understood by the following detailed description in conjunction with the accompanying drawings, wherein like reference numerals designate like structural elements.", "FIG.", "1 illustrates a system and method for masking open space noise in one example.", "FIG.", "2 illustrates a system and method for masking open space noise in a further example.", "FIG.", "3 illustrates a system for outputting a sound of flowing water from the speaker shown in FIG.", "1 in one example.", "FIG.", "4 illustrates a system for outputting a sound of flowing water and a noise from the speaker shown in FIG.", "2 in one example.", "FIG.", "5 illustrates placement of the speaker and the water element system shown in FIG.", "1 or FIG.", "2 in an open space in one example.", "FIG.", "6 illustrates placement of the speaker and the water element system shown in FIG.", "1 or FIG.", "2 in an open space in a further example.", "FIG.", "7 is a flow diagram illustrating masking open space noise in one example.", "FIG.", "8 is a flow diagram illustrating masking open space noise in one example.", "FIG.", "9 is a flow diagram illustrating masking open space noise in one example.", "FIG.", "10 illustrates placement of the speaker shown in FIG.", "1 in one example.", "FIG.", "11 illustrates the water element system shown in FIG.", "1 in one example.", "DESCRIPTION OF SPECIFIC EMBODIMENTS Methods and apparatuses for masking open space noise are disclosed.", "The following description is presented to enable any person skilled in the art to make and use the invention.", "Descriptions of specific embodiments and applications are provided only as examples and various modifications will be readily apparent to those skilled in the art.", "The general principles defined herein may be applied to other embodiments and applications without departing from the spirit and scope of the invention.", "Thus, the present invention is to be accorded the widest scope encompassing numerous alternatives, modifications and equivalents consistent with the principles and features disclosed herein.", "Block diagrams of example systems are illustrated and described for purposes of explanation.", "The functionality that is described as being performed by a single system component may be performed by multiple components.", "Similarly, a single component may be configured to perform functionality that is described as being performed by multiple components.", "For purpose of clarity, details relating to technical material that is known in the technical fields related to the invention have not been described in detail so as not to unnecessarily obscure the present invention.", "It is to be understood that various example of the invention, although different, are not necessarily mutually exclusive.", "Thus, a particular feature, characteristic, or structure described in one example embodiment may be included within other embodiments.", "In one example, a method for masking open space noise includes outputting from a speaker a speaker sound corresponding to a flow of water, and displaying a water element system, the water element system generating a sound of flowing water.", "In one example, a system for masking open space noise includes a speaker arranged to output a speaker sound in an open space, the speaker sound comprising a sound corresponding to a flow of water and a noise configured to mask open space noise.", "The system further includes a display of flowing water disposed in the open space.", "In one example, a method for masking open space noise includes outputting a first masking sound to mask an open space noise in an open space, and masking an audibility of the first masking sound utilizing a second masking sound, the second masking sound operable to mask the open space noise.", "In one example, a method for masking open space noise includes outputting from a speaker a speaker sound corresponding to a flow of water, outputting from the speaker a noise configured to mask open space noise, and displaying a flow of water.", "In example embodiments, methods and systems are presented for noise masking in offices and call centers.", "The methods and systems relate to the visual and acoustic design of indoor built environments and thereby concern the fields of facilities management, architecture, acoustics, and design.", "Modern work environments create large open office areas that introduce highly intelligible speech noise that consequently decreases productivity, speech privacy, and acoustic comfort.", "Methods and systems are presented for successfully reducing the speech noise intelligibility/interference, and increasing productivity, speech privacy, and acoustic comfort.", "In one example, a method and system for masking sound uses in-plenum natural water sounds combined with pink noise and a visual water element.", "The water sound carries significant high frequency noises that mask speech intelligibility more effectively than pink noise alone.", "The visual water element, i.e.", "the waterfall, makes workers believe that the waterfall causes their increase in comfort.", "Playing water sounds alone through the sound masking speakers, without a visual water element, causes discomfort among workers, who feel as though the water is dripping down from the ceiling or that it has no logical source.", "A logical source of the water sound is needed.", "The psychological effect of having the physical waterfall operate in conjunction with the masking sound is particularly advantageous.", "The methods and systems described provide a measurable decrease in the intelligibility of speech noise heard by workers in an open space environment.", "For example, such decrease can be measured using a speech transmission index (STI).", "In one example, the system functions by using speakers installed in the plenum (the area between the ceiling tiles and the ceiling) to produce a masking sound that is broadcast upwards toward the ceiling.", "The sound is directed upwards so that it reflects off of the ceiling and is bounced back toward the ground through the ceiling tiles with increased diffusion.", "Creating a more diffuse sound decreases the ability of the worker to identify the location of the speakers, and eliminates the creation of “hot” and “cold” spots, where the masking sound is loud or quiet enough to be highly noticeable.", "The masking sound used is a naturally occurring sound such as a natural water sound, which can be artificially generated or taken from an actual recording of water flow.", "In one example, actual recordings of a natural waterfall are made, then processed/equalized to a satisfactory spectrum to be most effective in masking open space noise.", "In one example, this water sound is mixed with electronically generated pink noise to increase the masking quality.", "In one example, the water sound is used alone.", "In conjunction with the masking sound, a physical water element such as a waterfall feature is introduced.", "By having a physical water element, the workers are less able to perceive a distinct masking sound, and perceive the masking sound to be coming directly from the waterfall feature, or perhaps reverberating off of the walls and windows.", "In one example, a significant and effective level of sound masking (e.g., 45-48 dB) is introduced without engaging the awareness of workers in the environment.", "In addition to avoiding engaging the awareness of workers, this method allows the use of a natural water sound—rather than an artificial pink noise sound—for masking in an office environment.", "The water sound is an improvement over a pink noise system alone, both in terms of its objective performance as a masking sound and in terms of its subjective appeal—put simply, people prefer the sound of running water to pink noise.", "This is supported by research in biophilia, which suggests that humans have certain innate preferences for natural sounds over artificial ones.", "Water sound with higher frequency components are particularly effective in masking in comparison to pink noise.", "In one example, a method and system provide a synergistic deployment of water sounds combined with pink noise from in-plenum speakers and a physical water wall to create the psychological perception of a natural water sound emanating from a water feature.", "Advantageously, the method operates without drawing attention to itself.", "Advantageously, the methods and systems create value to the end user by increasing his or her productivity at work while simultaneously increasing his or her comfort.", "Office densification is accelerating and is a major issue for most large companies.", "This trend is exacerbating acoustical problems and necessitating solutions to the office noise problem.", "Moreover, companies are increasingly focused on the productivity and comfort of their most important asset, their employees.", "Improving the employee experience is increasingly important for companies.", "FIG.", "1 illustrates a system and method for masking open space noise in one example.", "In one example, the system includes a speaker 2 arranged to output a speaker sound in an open space such as an office building room, the speaker sound including sound 4 corresponding to a flow of water.", "In one example, the sound 4 corresponding to the flow of water is a recording of a natural flow of water or an electronically synthesized sound of flow of water.", "In one example, the sound 4 corresponding to a flow of water has been optimized to mask open space noise.", "For example, a recording of the flow of water used to generate sound 4 has been processed to add 2-4 dB per octave higher frequency boost.", "The system further includes a display of flowing water disposed in the open space.", "In the example shown in FIG.", "1, the display of flowing water is a water element system 6.In one example, the water element system 6 is arranged to be easily visible within the open space.", "In one example, the water element system 6 is a floor-to-ceiling waterfall including an upper reservoir which receives water from a water supply, and a lower reservoir (e.g., a floor basin) to receive water which has fallen from the upper reservoir.", "The waterfall includes water recirculation tubes for recirculating water from the lower reservoir back to the upper reservoir, and a recirculation pump to recirculate the water through the recirculation tubes up to the upper reservoir.", "In one implementation, water falls from upper reservoir to the lower reservoir along the surfaces of one or more vertical glass panels disposed between the upper reservoir and the lower reservoir.", "FIG.", "11 illustrates the water element system 6 shown in FIG.", "1 in one example.", "In one example, the speaker 2 is one of a plurality of loudspeakers which are disposed in a plenum above the open space and arranged to direct the speaker sound in a direction opposite the open space.", "FIG.", "10 illustrates placement of the speaker 2 shown in FIG.", "1 in one example.", "The speaker sound is then reflected by the open space ceiling down into the open space.", "In one example, the speaker 2 is one of a plurality of speakers disposed at varying distances from the water element system 6, where an output level of the speaker sound from a speaker is adjusted based on the distance of the speaker 2 from the water element system 6.The speaker output level is adjusted so that the sound level of the flowing water (the sound 8 from the water element system 6 combined with the sound 4 of flowing water output from speaker 2) is consistent throughout the open space.", "At locations in close proximity to water element system 6, water sound 8 from the water element system 6 is heard.", "As such, the output level of a speaker 2 in close proximity to water element system 6 is reduced relative to a speaker 2 further away.", "In one example, sound 4 has been processed to match the frequency characteristics of water sound 8 emanating from water element system 6 so that the user is under the impression that sound 4 is emanating from water element system 6 instead of speaker 2.In this manner, the water element system 6 may be constructed so that it need not be so loud so as to be heard throughout the open space in order for the water sound to be an effective noise masker.", "This reduces the possibility that workers in close proximity to the water element system 6 will find the water sound too loud and annoying while allowing workers further away to hear water sound at a sufficient level to provide effective masking of the open space noise.", "Referring again to FIG.", "1, in one example operation, sound 4 corresponding to the flow of water output from speaker 2 operates to mask open space noise 20 heard by a person 10.Water sound 8 from water element system 6 also operates to mask open space noise 20.In the example shown in FIG.", "1, a conversation participant 12 is in conversation with a conversation participant 14 in the vicinity of person 10 in the open space.", "Open space noise 20 includes components of speech 16 from participant 12 and speech 18 from conversation participant 14.The intelligibility of speech 16 and speech 18 is reduced by sound 4 and sound 8.FIG.", "2 illustrates a system and method for masking open space noise in a further example.", "In the system illustrated in FIG.", "2, a sound 22 is output from speaker 2 corresponding to a noise configured to mask open space noise in addition to the sound 4 corresponding to the flow of water described in reference to FIG.", "1.In one example, the noise configured to mask open space noise output from speaker 2 is a random noise such as pink noise.", "Both sound 4 and sound 22 operate to mask open space noise 20 heard by person 10.In one example, the sound 4 corresponding to the flow of water is output at a sound level sufficient to partially mask or completely mask the noise sound 22.For example, this is advantageous where persons prefer to hear the sound of pink noise at a reduced level or not to hear the sound of pink noise.", "In one example, the output levels of sound 4 and noise sound 22 are determined experimentally and/or based on listener preference.", "The use of sound 4 and sound 22 produces a greater masking effect than the use of either sound 4 or sound 22 alone, while providing for increased listener comfort.", "In one example, the speaker sound 4 corresponding to the flow of water is optimized to mask a higher frequency open space noise than the noise sound 22 configured to mask open space noise.", "For example, a frequency boost of 2-4 dB per octave is added in the processing of the recorded water sound.", "In this manner, noise sound 22 can be selected to mask lower frequency open space noise.", "For example, noise sound 22 can be selected to be a pink noise which is more appealing to be heard by persons instead of a white noise, which is slightly more effective in masking higher frequency open space noise but more unpleasant for persons to hear.", "In one example, a method for masking open space noise (e.g., noise 20) includes outputting a first masking sound (e.g., sound 22, such as a pink noise) to mask an open space noise (e.g., noise 20) in an open space, and masking an audibility of the first masking sound (e.g., sound 22) utilizing a second masking sound (e.g., sound 4), the second masking sound (e.g., sound 4) also operable to mask the open space noise (e.g., noise 20).", "This methodology allows the level of the first masking sound (e.g., sound 22) to be increased (i.e., to produce a greater masking effect of noise 20) without being perceived by person 10.This is advantageous where person 10 finds hearing increased levels of the first masking sound by itself unpleasant.", "The method further includes generating a natural sound (e.g., sound 8) associated with the second masking sound (e.g., sound 4), the natural sound generated with a water element system (e.g., water element system 6) displayed in the open space.", "The natural sound also operates to mask the open space noise.", "The presence of water element system 6 emitting sound 8 advantageously allows the use of water sound 4 to be output from speaker 2 as the person 10 has the impression that sound 4 is emanating from water element system 6.FIG.", "5 illustrates placement of a plurality of speakers 2 and the water element system shown in FIG.", "1 or FIG.", "2 in an open space 500 in one example.", "For example, open space 500 may be a large room of an office building in which employee cubicles are placed.", "FIG.", "6 illustrates placement of the plurality of speakers 2 and the water element system shown in FIG.", "1 or FIG.", "2 in an open space 600 in a further example.", "FIG.", "3 illustrates a system for outputting the sound 4 of flowing water from the speaker 2 shown in FIG.", "1 in one example.", "A water sound player 30 outputs an audio signal 34 of a sound of flowing water.", "Audio signal 34 is received by an amplifier 32, which outputs an amplified audio signal 36.Amplified audio signal 36 is received by speaker 2 (e.g., a loudspeaker), which outputs the sound 4 of flowing water.", "In one example, water sound player 30 is an application program at a computing device.", "For example, the water sound player 30 may be a digital music player on a personal computer playing back an audio file containing a recording of the sound of a waterfall.", "FIG.", "4 illustrates a system for outputting a sound of flowing water and a noise from the speaker 2 shown in FIG.", "2 in one example.", "A water sound player 38 outputs an audio signal 40 of a sound of flowing water.", "A random noise player 42 outputs an audio signal 44 of a sound of random noise (e.g., pink noise).", "In one example, water sound player 38 and random noise player 42 are application programs at a computing device.", "Although shown as separate applications, they may be integrated into a single application, such as a digital music player playing back audio files containing a recording of the sound of a waterfall and a recording of random noise.", "Audio signal 40 and audio signal 44 are received at mixer 46, which outputs a mixed audio signal 48 containing both audio signal 40 and audio signal 44.Mixed audio signal 48 is received at amplifier 50, which outputs an amplified mixed audio signal 52.Amplified mixed audio signal 52 is received by speaker 2, which outputs sound 4 of flowing water and sound 22 of random noise.", "FIG.", "7 is a flow diagram illustrating masking open space noise in one example.", "At block 702, a speaker sound is output from a speaker corresponding to a flow of water.", "In one example, the speaker sound corresponding to the flow of water is a recording of a natural flow of water or an electronically synthesized sound of flow of water.", "In one example, the speaker sound corresponding to a flow of water has been optimized to mask open space noise.", "For example, a frequency boost of 2-4 dB per octave is added in the processing of the recorded water sound.", "At block 704, a water element system is displayed, the water element system generating a sound of flowing water.", "In one example, the water element system is a waterfall.", "In one example, the water element system is a waterfall disposed in an open space, and the speaker is one of a plurality of speakers comprise speakers disposed at varying distances from the waterfall.", "The process further includes adjusting an output level of the speaker sound corresponding to the flow of water in the plurality of speakers based on the distance of a speaker from the waterfall.", "In one example, the process further includes outputting from the speaker a noise configured to mask open space noise.", "For example, the noise configured to mask open space noise is a pink noise.", "In one example, the speaker sound corresponding to the flow of water output from the plurality of speakers is output at a sound level configured to partially or completely mask the noise configured to mask open space noise.", "In one example, the speaker sound corresponding to the flow of water is optimized to mask a higher frequency open space noise than the noise configured to mask open space noise by adding several dB per octave higher frequency boost.", "FIG.", "8 is a flow diagram illustrating masking open space noise in one example.", "At block 802, a first masking sound is output to mask an open space noise in an open space.", "At block 804, an audibility of the first masking sound is masked utilizing a second masking sound, the second masking sound operable to mask the open space noise.", "In one example, the first masking sound is a pink noise and the second masking sound is a sound of a flow of water.", "In one example, the user of the second masking sound allows for an increased level of the first masking sound without a listener noticing the increased level.", "In this manner, greater levels of open space noise masking are enabled while minimizing the possibility that listeners will be annoyed by hearing increased levels of the first masking noise.", "In one example, the first masking sound is a pink noise and the second masking sound is a natural sound comprising sounds associated with a nature environment, the nature environment comprising a rainforest.", "For example, the rainforest may be shown on a display screen and the sound of the rainforest output from speakers.", "In one example, a first masking sound level of the first masking sound or a second masking sound level of the second masking sound are changed as a function of time (i.e., modulated).", "In one example, the method further includes generating a natural sound associated with the second masking sound, the natural sound generated with a visual water element system displayed in the open space.", "For example, the water element system is a waterfall.", "In one example, the natural sound operates to allow for the use of the second masking sound by providing a logical source for the second masking sound.", "FIG.", "9 is a flow diagram illustrating masking open space noise in one example.", "At block 902, a speaker sound corresponding to a flow of water is output from a speaker.", "In one example, the speaker sound corresponding to the flow of water is a recording of a natural flow of water or an electronically synthesized sound of a flow of water.", "In one example, the speaker sound corresponding to the flow of water is optimized to mask a higher frequency open space noise than the noise configured to mask open space noise.", "At block 904, a noise configured to mask open space noise is output from the speaker.", "In one example, the noise configured to mask open space noise is a pink noise.", "At block 906, a flow of water is displayed.", "In one example, the flow of water is a waterfall generating an audible sound.", "In a further example, the display of flowing water is a video recording of a flow of water shown on an electronic display.", "In one example, the speaker sound corresponding to the flow of water is output at a sound level sufficient to mask the noise configured to mask open space noise output from the speaker.", "In one example, the flow of water is a waterfall disposed in an open space, and the speaker is one of a plurality of speakers disposed at varying distances from the waterfall.", "The process further includes adjusting an output level of the speaker sound corresponding to the flow of water in the plurality of speakers based on the distance of a speaker from the waterfall.", "While the exemplary embodiments of the present invention are described and illustrated herein, it will be appreciated that they are merely illustrative and that modifications can be made to these embodiments without departing from the spirit and scope of the invention.", "Acts described herein may be computer readable and executable instructions that can be implemented by one or more processors and stored on a computer readable memory or articles.", "The computer readable and executable instructions may include, for example, application programs, program modules, routines and subroutines, a thread of execution, and the like.", "In some instances, not all acts may be required to be implemented in a methodology described herein.", "Terms such as “component”, “module”, and “system” are intended to encompass software, hardware, or a combination of software and hardware.", "For example, a system or component may be a process, a process executing on a processor, or a processor.", "Furthermore, a functionality, component or system may be localized on a single device or distributed across several devices.", "The described subject matter may be implemented as an apparatus, a method, or article of manufacture using standard programming or engineering techniques to produce software, firmware, hardware, or any combination thereof to control one or more computing devices.", "Thus, the scope of the invention is intended to be defined only in terms of the following claims as may be amended, with each claim being expressly incorporated into this Description of Specific Embodiments as an embodiment of the invention." ] ]
Patent_15872853
[ [ "SCAFFOLDING HAVING A COUPLING", "A scaffolding has a coupling which can be mounted at a connection location.", "The connection location in this instance has a recess in the form of a through-recess in which an angular portion of the coupling can be at least partially introduced.", "The angular portion engages partially behind the connection location.", "The coupling may have a half-coupling so that a simple connection to a scaffolding pipe, in particular for connecting to a facade, is produced.", "A method for connecting the scaffolding to such a coupling is also taught herein." ], [ "1.A scaffolding, comprising: a coupling for a scaffolding retention member for connecting the scaffolding to a building facade; a scaffolding shaft which is vertical in the assembled state; and a connection location which is rigidly connected to the scaffolding shaft in the form of an anchor plate portion; wherein the coupling is connected at a recess of the connection location which is suitable for system components of the scaffolding in the form of an anchor plate portion; and wherein the coupling has a clip-like half-coupling for receiving a scaffolding pipe.", "2.The scaffolding according to claim 1, wherein the coupling has an angular portion in order to connect the coupling to the connection location.", "3.The scaffolding according to claim 1, wherein the coupling can be connected to the connection location in a tool-free manner.", "4.The scaffolding according to claim 2, wherein the angular portion of the coupling is constructed to partially engage behind an inner edge of the recess of the connection location which is constructed in the form of a through-recess.", "5.The scaffolding according to claim 4, wherein the angular portion of the coupling is at least a portion of a bent rod of the coupling.", "6.The scaffolding according to claim 1, wherein the coupling has a nose-like projection so that the coupling can be secured in the recess of the connection location by means of a clamping connection.", "7.The scaffolding according to claim 2, wherein the angular portion of the coupling is constructed as a portion of a T-shaped portion of the coupling.", "8.The scaffolding according to claim 2, wherein the angular portion of the coupling is constructed as a portion of a T-shaped portion of the coupling.", "9.The scaffolding according to claim 1, wherein the coupling has the scaffolding pipe which is received in the half-coupling and which can be connected at one end by means of a facade connection to the building facade.", "10.The scaffolding according to claim 8, wherein the coupling has the scaffolding pipe which is received in the half-coupling and which can be connected at one end by means of a facade connection to the building facade.", "11.The scaffolding according to claim 10, wherein the scaffolding pipe is connected to the facade connection of the building facade.", "12.A method for connecting the coupling to the scaffolding according to claim 1, wherein the coupling is arranged at the connection location of the scaffolding, wherein the connection location is constructed in the form of the anchor plate portion." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>It is known in scaffolding construction to provide a coupling for the connection of individual components of a scaffolding.", "It is further known to secure a scaffolding, in particular a facade scaffolding, to a building facade by means of a scaffolding retention member.", "The connection between the scaffolding retention member and scaffolding is generally carried out in this instance by means of a so-called normal coupling by which a pipe of the scaffolding retention member is connected to a pipe of the scaffolding.", "Such a normal coupling has two half-couplings of which a first half-coupling is connected to the pipe of the scaffolding retention member and a second half-coupling is connected to a vertical scaffolding shaft of the scaffolding.", "The half-couplings are generally in the form of half-clips.", "In order to install the normal coupling, two half-couplings consequently have to be closed and screwed shut.", "These operating steps are time-intensive and complex for a scaffolding constructor, in particular when he has only one hand free for closing and screwing the normal coupling.", "Another disadvantage of the use of normal couplings for connecting a scaffolding retention member is that the spacing between the scaffolding retention member and scaffolding node as a result of the width of the half-clip is relatively large, which has an unfavourable effect on the introduction of forces into the scaffolding shaft.", "In scaffolding construction, it is further known to use bracing couplings for connecting a scaffolding pipe which acts as a scaffolding retention member to a lug of an annular screw which is fitted to a facade.", "The bracing couplings have in this instance a rod which is bent multiple times and which is introduced into the lug and is located in continuation of the center line of the scaffolding retention member which is intended to be assembled in order to ensure a favourable force path.", "The disadvantage is that it thereby constitutes a limitation for the scaffolding pipe.", "The known bracing couplings are used only at the facade side.", "Finally, it is known from scaffolding construction to use carrier couplings for connecting a scaffolding to a steel carrier or the like.", "However, carrier couplings can only be mounted in a relatively complex manner.", "An object of the present invention is in this regard to provide a scaffolding or a method with which a rapid connection of a scaffolding component is enabled with little structural complexity." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>This object of the present invention is achieved with a scaffolding having the features of the apparatus patent claim and a method according to the method patent claim.", "The dependent subordinate claims set out further advantageous developments.", "The object according to the invention is consequently achieved with a scaffolding having a coupling for a scaffolding retention member for connecting the scaffolding to a building facade, wherein the coupling can be connected at a recess of a connection location of a scaffolding node which is suitable for system components of the scaffolding.", "The connection location is in this instance constructed in the form of an anchor plate portion.", "The coupling according to the invention, without the use of a clip which surrounds the scaffolding shaft, can thereby be connected to the connection location on a scaffolding node.", "This enables securing of a scaffolding to a facade in a manner which is as simple as possible in terms of construction and handling technology.", "In this instance, a scaffolding node is intended to be understood to be a location which is provided on a scaffolding shaft with regular spacing and at which at least two connection locations for system components, such as longitudinal and/or transverse bars, scaffolding floors, diagonals and the like, are provided and at which the system components can be fitted without using a clip which surrounds the pipe of the scaffolding shaft, at least at substantially the same height.", "If bars are securely connected to the scaffolding shaft, even when only one connection location is present there is a scaffolding node present in the context of this application.", "These scaffolding nodes are constructed in many commercially available modular scaffoldings in the form of anchor plates, perforated discs, pockets, cup-like receiving members or other suitable receiving members.", "The solution according to the invention consequently makes use of the fact that most modular scaffoldings have in the region of the scaffolding nodes connection locations which can be used for connection to a coupling.", "The coupling according to the invention is consequently constructed in a structurally very simple manner and can be rapidly assembled without activating a screw connection.", "In a preferred embodiment of the invention, the coupling has an angular portion in order to connect the coupling to the connection location.", "In a further preferred manner, the coupling according to the invention can be connected to the connection location in a tool-free manner.", "The recess of the connection location is preferably constructed in the form of a through-recess.", "For connection to such a connection location, the angular portion can be constructed to partially engage behind an inner edge of the through-recess.", "The angular portion may be at least a portion of a bent rod of the coupling.", "In a preferred embodiment of the coupling, the angular portion is completely constructed in the form of a rod which is bent in a simple manner.", "Alternatively or additionally, the coupling may have a nose-like projection so that the coupling can be secured in the recess of the connection location by means of a clamping connection.", "The nose-like projection in this instance constitutes a rotation prevention member of the coupling relative to the connection location.", "The rotation prevention member is in this instance preferably constructed in such a manner that it prevents rotation about the longitudinal axis of the recess.", "The angular portion may be constructed as part of a T-shaped portion of the coupling.", "As a result of the T-shaped portion, the coupling is retained at the connection location in a particularly secure manner.", "That is to say, the coupling may engage behind the through-recess of the connection location with “both upper side arms of the T-shape”.", "A T-shaped portion is intended to be understood in this instance to be a portion which has at least two, in particular angled, projections for engaging behind the through-recess in the connection location.", "The coupling may be rigidly connected to another scaffolding element, in particular a scaffolding pipe.", "Alternatively or additionally, the coupling may have a clip-like half-coupling for receiving a scaffolding pipe.", "The coupling provides in this instance, on the one hand, a rapid connection to the connection location of the scaffolding and, on the other hand, a flexible possibility for connecting a scaffolding retention member, in particular in the form of a scaffolding pipe, to the coupling.", "Preferably, the scaffolding pipe extends parallel or perpendicularly with respect to the plane of a plate-like portion of the coupling.", "The half-coupling is particularly preferably arranged in such a manner that a tubular scaffolding retention member of any length can be introduced into the half-coupling.", "That is to say, the half-coupling is preferably orientated in such a manner that a tubular scaffolding retention member which is introduced into the half-coupling does not strike a portion of the coupling.", "Alternatively or additionally, the half-coupling may be constructed in such a manner that a tubular scaffolding retention member which is introduced into the half-coupling does not strike a portion of the scaffolding.", "In this manner, the tubular scaffolding retention member does not have to be cut to the length of the spacing of the scaffolding with respect to the scaffolding.", "The coupling may receive in the half-coupling a scaffolding pipe which can be connected at one end by means of a facade connection to a building facade.", "At the other end, the scaffolding pipe is in this instance preferably connected to the angular portion by means of the half-coupling.", "The coupling can be connected at the recess of the connection location which is suitable for system components of a scaffolding in the form of an anchor plate portion.", "The term anchor plate portion is intended to be understood to be a flat plate which has any outer contour and which extends perpendicularly away from the center axis of a scaffolding shaft and which is provided with at least one, preferably up to eight recesses which are preferably surrounded at all sides and in which fitted components, such as, for example, bars or consoles, can be secured.", "Generally, such anchor plate portions are arranged with regular spacings, the so-called vertical modular dimension, on the vertical shafts of, for example, modular scaffoldings.", "The anchor plate portion may be constructed in the form of a portion of an anchor plate so that the anchor plate portion only partially surrounds a scaffolding shaft and/or does not have recesses in all radial directions.", "Preferably, the anchor plate portion is constructed in the form of an anchor plate which completely surrounds the scaffolding shaft.", "The object according to the invention is achieved with a scaffolding having a coupling as described above, a scaffolding shaft which is vertical in the assembled state and a connection location which is rigidly connected to the scaffolding shaft, wherein the connection location is connected to the coupling.", "The scaffolding shaft is connected to the connection location in this instance, in particular by means of a weld connection and/or a clamping connection.", "The scaffolding pipe is preferably connected to the facade connection of a building facade.", "The object according to the invention is further achieved with a method for connecting a coupling described above to a scaffolding described above, in which the coupling is arranged, in particular in a tool-free manner, at a connection location of the scaffolding.", "In this case, the coupling is preferably connected to the scaffolding by means of a recess of the connection location in the form of a through-recess.", "In the method according to the invention, the connection location is constructed in the form of an anchor plate portion.", "Other features and advantages of the invention will be appreciated from the following detailed description of two embodiments of the invention, from the patent claims and the Figures of the drawings which show details which are significant to the invention." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This continuation application claims priority to PCT/EP2016/066509 filed on Jul.", "12, 2016 which has published as WO 2017/012919 A1 and also the German application number 10 2015 213 737.6 filed on Jul.", "21, 2015, the entire contents of which are fully incorporated herein with these references.", "DESCRIPTION FIELD OF THE INVENTION The present invention generally relates to scaffolding used in construction.", "More specifically, the present invention relates to a scaffolding having a coupling which can be mounted at a connection location.", "BACKGROUND OF THE INVENTION It is known in scaffolding construction to provide a coupling for the connection of individual components of a scaffolding.", "It is further known to secure a scaffolding, in particular a facade scaffolding, to a building facade by means of a scaffolding retention member.", "The connection between the scaffolding retention member and scaffolding is generally carried out in this instance by means of a so-called normal coupling by which a pipe of the scaffolding retention member is connected to a pipe of the scaffolding.", "Such a normal coupling has two half-couplings of which a first half-coupling is connected to the pipe of the scaffolding retention member and a second half-coupling is connected to a vertical scaffolding shaft of the scaffolding.", "The half-couplings are generally in the form of half-clips.", "In order to install the normal coupling, two half-couplings consequently have to be closed and screwed shut.", "These operating steps are time-intensive and complex for a scaffolding constructor, in particular when he has only one hand free for closing and screwing the normal coupling.", "Another disadvantage of the use of normal couplings for connecting a scaffolding retention member is that the spacing between the scaffolding retention member and scaffolding node as a result of the width of the half-clip is relatively large, which has an unfavourable effect on the introduction of forces into the scaffolding shaft.", "In scaffolding construction, it is further known to use bracing couplings for connecting a scaffolding pipe which acts as a scaffolding retention member to a lug of an annular screw which is fitted to a facade.", "The bracing couplings have in this instance a rod which is bent multiple times and which is introduced into the lug and is located in continuation of the center line of the scaffolding retention member which is intended to be assembled in order to ensure a favourable force path.", "The disadvantage is that it thereby constitutes a limitation for the scaffolding pipe.", "The known bracing couplings are used only at the facade side.", "Finally, it is known from scaffolding construction to use carrier couplings for connecting a scaffolding to a steel carrier or the like.", "However, carrier couplings can only be mounted in a relatively complex manner.", "An object of the present invention is in this regard to provide a scaffolding or a method with which a rapid connection of a scaffolding component is enabled with little structural complexity.", "SUMMARY OF THE INVENTION This object of the present invention is achieved with a scaffolding having the features of the apparatus patent claim and a method according to the method patent claim.", "The dependent subordinate claims set out further advantageous developments.", "The object according to the invention is consequently achieved with a scaffolding having a coupling for a scaffolding retention member for connecting the scaffolding to a building facade, wherein the coupling can be connected at a recess of a connection location of a scaffolding node which is suitable for system components of the scaffolding.", "The connection location is in this instance constructed in the form of an anchor plate portion.", "The coupling according to the invention, without the use of a clip which surrounds the scaffolding shaft, can thereby be connected to the connection location on a scaffolding node.", "This enables securing of a scaffolding to a facade in a manner which is as simple as possible in terms of construction and handling technology.", "In this instance, a scaffolding node is intended to be understood to be a location which is provided on a scaffolding shaft with regular spacing and at which at least two connection locations for system components, such as longitudinal and/or transverse bars, scaffolding floors, diagonals and the like, are provided and at which the system components can be fitted without using a clip which surrounds the pipe of the scaffolding shaft, at least at substantially the same height.", "If bars are securely connected to the scaffolding shaft, even when only one connection location is present there is a scaffolding node present in the context of this application.", "These scaffolding nodes are constructed in many commercially available modular scaffoldings in the form of anchor plates, perforated discs, pockets, cup-like receiving members or other suitable receiving members.", "The solution according to the invention consequently makes use of the fact that most modular scaffoldings have in the region of the scaffolding nodes connection locations which can be used for connection to a coupling.", "The coupling according to the invention is consequently constructed in a structurally very simple manner and can be rapidly assembled without activating a screw connection.", "In a preferred embodiment of the invention, the coupling has an angular portion in order to connect the coupling to the connection location.", "In a further preferred manner, the coupling according to the invention can be connected to the connection location in a tool-free manner.", "The recess of the connection location is preferably constructed in the form of a through-recess.", "For connection to such a connection location, the angular portion can be constructed to partially engage behind an inner edge of the through-recess.", "The angular portion may be at least a portion of a bent rod of the coupling.", "In a preferred embodiment of the coupling, the angular portion is completely constructed in the form of a rod which is bent in a simple manner.", "Alternatively or additionally, the coupling may have a nose-like projection so that the coupling can be secured in the recess of the connection location by means of a clamping connection.", "The nose-like projection in this instance constitutes a rotation prevention member of the coupling relative to the connection location.", "The rotation prevention member is in this instance preferably constructed in such a manner that it prevents rotation about the longitudinal axis of the recess.", "The angular portion may be constructed as part of a T-shaped portion of the coupling.", "As a result of the T-shaped portion, the coupling is retained at the connection location in a particularly secure manner.", "That is to say, the coupling may engage behind the through-recess of the connection location with “both upper side arms of the T-shape”.", "A T-shaped portion is intended to be understood in this instance to be a portion which has at least two, in particular angled, projections for engaging behind the through-recess in the connection location.", "The coupling may be rigidly connected to another scaffolding element, in particular a scaffolding pipe.", "Alternatively or additionally, the coupling may have a clip-like half-coupling for receiving a scaffolding pipe.", "The coupling provides in this instance, on the one hand, a rapid connection to the connection location of the scaffolding and, on the other hand, a flexible possibility for connecting a scaffolding retention member, in particular in the form of a scaffolding pipe, to the coupling.", "Preferably, the scaffolding pipe extends parallel or perpendicularly with respect to the plane of a plate-like portion of the coupling.", "The half-coupling is particularly preferably arranged in such a manner that a tubular scaffolding retention member of any length can be introduced into the half-coupling.", "That is to say, the half-coupling is preferably orientated in such a manner that a tubular scaffolding retention member which is introduced into the half-coupling does not strike a portion of the coupling.", "Alternatively or additionally, the half-coupling may be constructed in such a manner that a tubular scaffolding retention member which is introduced into the half-coupling does not strike a portion of the scaffolding.", "In this manner, the tubular scaffolding retention member does not have to be cut to the length of the spacing of the scaffolding with respect to the scaffolding.", "The coupling may receive in the half-coupling a scaffolding pipe which can be connected at one end by means of a facade connection to a building facade.", "At the other end, the scaffolding pipe is in this instance preferably connected to the angular portion by means of the half-coupling.", "The coupling can be connected at the recess of the connection location which is suitable for system components of a scaffolding in the form of an anchor plate portion.", "The term anchor plate portion is intended to be understood to be a flat plate which has any outer contour and which extends perpendicularly away from the center axis of a scaffolding shaft and which is provided with at least one, preferably up to eight recesses which are preferably surrounded at all sides and in which fitted components, such as, for example, bars or consoles, can be secured.", "Generally, such anchor plate portions are arranged with regular spacings, the so-called vertical modular dimension, on the vertical shafts of, for example, modular scaffoldings.", "The anchor plate portion may be constructed in the form of a portion of an anchor plate so that the anchor plate portion only partially surrounds a scaffolding shaft and/or does not have recesses in all radial directions.", "Preferably, the anchor plate portion is constructed in the form of an anchor plate which completely surrounds the scaffolding shaft.", "The object according to the invention is achieved with a scaffolding having a coupling as described above, a scaffolding shaft which is vertical in the assembled state and a connection location which is rigidly connected to the scaffolding shaft, wherein the connection location is connected to the coupling.", "The scaffolding shaft is connected to the connection location in this instance, in particular by means of a weld connection and/or a clamping connection.", "The scaffolding pipe is preferably connected to the facade connection of a building facade.", "The object according to the invention is further achieved with a method for connecting a coupling described above to a scaffolding described above, in which the coupling is arranged, in particular in a tool-free manner, at a connection location of the scaffolding.", "In this case, the coupling is preferably connected to the scaffolding by means of a recess of the connection location in the form of a through-recess.", "In the method according to the invention, the connection location is constructed in the form of an anchor plate portion.", "Other features and advantages of the invention will be appreciated from the following detailed description of two embodiments of the invention, from the patent claims and the Figures of the drawings which show details which are significant to the invention.", "BRIEF DESCRIPTION OF THE DRAWINGS The features shown in the drawings are illustrated in such a manner that the specific features according to the invention can be made clearly visible.", "The different features can be implemented individually per se or together in any combination in variants of the invention.", "In the drawings: FIG.", "1 is a perspective partial view of a scaffolding according to the invention with a coupling; FIG.", "2a is a perspective view of another coupling; and FIG.", "2b is a plan view of the additional coupling according to FIG.", "2a.", "DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS FIG.", "1 shows a portion of a scaffolding 10.Of the scaffolding 10, a connection location 12 in the form of an anchor plate portion can be seen in FIG.", "1.The connection location 12 is secured to a vertical scaffolding shaft 14, in particular welded.", "At the connection location 12, a coupling 18 is arranged or coupled.", "The coupling 18 serves to connect the connection location 12 to a scaffolding retention member which is not illustrated in FIG.", "1 and which secures the scaffolding 10 to a building facade (not shown).", "By way of illustration, the longitudinal axis 20 of the tubular scaffolding retention member is shown in FIG.", "1.The scaffolding retention member can be connected at one end by means of a facade connection (not shown) to the building facade.", "At the other end, the scaffolding retention member is received by means of a half-coupling 22 of the coupling 18.In this case, the half-coupling 22 is constructed in the form of a clip (clamp) in which the pipe of the scaffolding retention member is retained by closing a screw connection 24.The half-coupling 22 is connected to a plate-like portion 28 by means of a weld connection 26.Alternatively, it could also be rotatably connected to the plate-like portion 24, for example, by means of a screw or rivet connection.", "By means of an additional weld connection which is not provided with a reference numeral, the plate-like portion 28 is connected to an angular portion 30 of the coupling 18.The angular portion 30 is constructed in the form of a rod which is bent in a simple manner.", "The angular portion 30 is guided through a first recess 32 which is constructed in the form of a through-recess.", "The connection location 12 has additional recesses in the form of through-recesses, wherein an additional recess 34 is provided with a reference numeral.", "A coupling 18 which can be connected to the additional recess 34 is illustrated in FIGS.", "2a, 2b and described below.", "FIG.", "2a shows the coupling 18 with a half-coupling 22 for receiving a tubular scaffolding retention member.", "On the half-coupling 22 a plate-like portion 28 is arranged, in particular in a rotationally secure manner.", "Furthermore, the coupling 18 has a T-shaped portion 36.The T-shaped portion 36 has a first upper side arm 38, a second upper side arm 40 and a lower portion 42.The T-shaped portion 36 is connected to the plate-like portion 28 by means of the lower portion 42.As a result of the first upper side arm 38 and the lower portion 42, a first angular portion 44 is formed.", "As a result of the second upper side arm 40 and the lower portion 42, a second angular portion 46 is formed.", "As can be seen from an overview of FIGS.", "1 and 2a, the coupling 18 is retained partially between the upper side arms 38, 40 and the plate-like portion 28 in the assembled state of the coupling 18 on the connection location 12.A nose-like projection 48 in the assembled state of the coupling 18 prevents the coupling 18 from becoming unintentionally released in the position thereof mounted on the connection location 12 (see FIG.", "1).", "The nose-like projection 28 is located—as illustrated in FIG.", "2a—preferably in the transition region between the plate-like portion 28 and the lower portion 42.FIG.", "2b is a plan view of the coupling 18 according to FIG.", "2a.", "In FIG.", "2b, it can be seen that the T-shaped portion 36 is constructed in an asymmetrical manner with respect to the longitudinal center plane 50 of the coupling 18.The second upper side arm 40 is constructed to be longer than the first upper side arm 38.Alternatively or additionally, the lower portion 42 has a notch 52.The above-mentioned features facilitate the securing of the T-shaped portion 36 in the Ω-shaped additional recess 34 (see FIG.", "1).", "The T-shaped portion 36 may also be constructed symmetrically relative to the longitudinal center plane 50.If the additional recess 34 of the connection location 12 has a different shape, for example, a trapezoidal shape, the upper side arms 38, 40, the nose-like projection 48 and the length of the plate-like portion 28 have to be adapted accordingly.", "These are then additional embodiments of the invention.", "In an overview of all the Figures of the drawings, the invention relates to a scaffolding 10 with a coupling 18 which can be mounted at a connection location 12.The connection location 12 preferably has in this instance a recess 32, 34 in the form of a through-recess in which an angular portion 30, 44, 46 of the coupling 18 can be at least partially introduced.", "The angular portion 30, 44, 46 preferably partially engages behind the connection location 12.The coupling 18 may have a half-coupling 22 so that a simple connection to a scaffolding pipe, in particular for connection to a facade, is produced.", "The invention further relates to a method for connecting the scaffolding 10 to such a coupling 18." ] ]
Patent_15872854
[ [ "Method and Apparatus for Providing Business Object Information", "A method and an apparatus for providing business object information are disclosed.", "The method includes pre-establishing a first database by a server, the first database being used for storing body property data of first users; determining a first business object information set for a client of a target first user; determining target body property data of the target first user based on the first database; determining whether an inventory of a target model that matches the target body property data exists in business objects in the first business object information set; and providing business object information to the client of the target first user based on a determination result.", "Through the embodiments of the present disclosure, the waste of network resources caused by transmission of invalid information can be reduced, and the effectiveness of information displayed in a list interface of a client is improved." ], [ "1.A method implemented by a server, the method comprising: pre-establishing a first database, the first database being used for storing body property data of first users; determining a first business object information set for a client of a target first user; determining target body property data of the target first user based on the first data base; determining whether inventories of target models that match the target body property data exists in business objects in the first business object information set; and providing business object information to the client of the target first user based on a determination result.", "2.The method of claim 1, wherein determining the target body property data of the target first user based on the first database comprises extracting the target body property data of the target first user in corresponding reference dimensions of the body property data from the first database based on categories to which the business objects in the first business object information set belong and pre-established correspondence relationships between the categories and the reference dimensions.", "3.The method of claim 1, wherein determining whether the inventories of the target models that match the target body property data exists in the business objects in the first business object information set comprises: determining the target models of the business object in the first business object information set that match the body property data of the first user; and determining whether the target models of the business objects are in stock by accessing a server of an inventory center.", "4.The method of claim 3, further comprising pre-establishing a second database, wherein the second database is used for storing first correspondence relationships between the models of the business objects and body property data ranges, each business object category corresponds to a different first correspondence relationship, and dimensions of the body property data are different in different first correspondence relationships, wherein determining the target models of the business object in the first business object information set that match the body property data of the first user comprises: determining a target category to which the business object belong for the business objects in the first business object information set; determining a first correspondence relationship corresponding to the target category; and setting models corresponding to a target body property data range as the matched target models when the target body property data is located in the target body property data range in the first correspondence relationship.", "5.The method of claim 4, wherein: determining the first business object information set for the client of the target first user comprises determining the first business object information set based on information of a designated category included in a browsing request when receiving the browsing request for browsing the designated category from the client of the target first user, and determining the target category to which the business object belong for the business objects in the first business object information set comprises setting the information of the designated category included in the browsing request as the target category to which the business objects belong.", "6.The method of claim 4, wherein: determining the first business object information set for the client of the target first user comprises determining the first business object information set based on a search keyword included in a search request when receiving the search request from the client of the target first user, and determining category information corresponding to the search keyword included in the search request and setting the category information as the target category to which the business objects belong.", "7.The method of claim 3, further comprising pre-establishing a third database, the third database being used for storing second correspondence relationships between the models of the business objects and the body property data ranges, wherein the business objects individually correspond to the second correspondence relationships, wherein determining the target models of the business object in the first business object information set that match the body property data of the first user comprises: determining target second correspondence relationships corresponding to the target business objects for the target business objects in the first business object information set; and setting models corresponding to target body property data ranges to be matched target models when the target property data is located in the target body property data ranges of the target second correspondence relationships.", "8.The method of claim 1, wherein providing the business object information to the client of the target first user based on the determination result comprises: forming a second business object set using business objects with target models being in stock; and providing the display content in a list page to the client using the second business object set.", "9.The method of claim 1, further comprising providing information of the target models for the business objects with the target models being in stock, to enable the client of the first user to display the information of the target models of the business objects in a list page.", "10.The method of claim 9, wherein providing the information of the target models for the business objects with the target models being in stock comprises adding the information of the target models in texts of respective links of the business objects for the business objects with the target models being in stock.", "11.The method of Clause 1, further comprising providing target body property data of the target first user in reference dimensions corresponding to a target category to the client of the first user when the business objects in the first business object set all belong to the target category, to allow the client of the first user to display thereof in a list page.", "12.One or more computer-readable media storing executable instructions that, when executed by one or more processors, cause the one or more processors to perform acts comprising: receiving business object information from a server by a first user client, the business object information being determined by the server using a way including pre-establishing a first database by the server, the first database being used for storing body property data of first users, determining a first business object information set for a client of a target first user; determining target body property data of the target first user based on the first database, determining whether inventories of target models that match the target body property data exists in business objects in the first business object information set, and providing business object information to the first user client based on a determination result; and generating display content in a list display page based on the received business object information.", "13.The one or more computer-readable media of claim 12, wherein the information returned by the server further comprises the models corresponding to the business objects, and the method further comprises displaying information of the models in the list display page.", "14.The one or more computer-readable media of claim 13, wherein displaying the information of the models in the list display page comprises displaying the information of the models in texts of links of the business objects.", "15.The one or more computer-readable media of claim 12, wherein the information returned by the server further comprises target body property data of the target first user with respect to a reference dimension corresponding to a same target category when the business objects in the first business object set belong to the target category, and the acts further comprise displaying the target body property data of the target first user in the reference dimension corresponding to the target category in the list display page.", "16.The one or more computer-readable media of claim 15, the acts further comprising: providing an option of operation for editing the body property data in the reference dimension in the list page; and uploading modified body property data to the server when the modified body property data is received through the option of operation, to enable the server to update provided business object information based on the modified body property data.", "17.An apparatus for providing business object information, which is applied in a server, the apparatus comprising: a first data database creation unit used for pre-establishing a first database by a server, the first database being used for storing body property data of first users; a first set determination unit used for determining a first business object information set for a client of a target first user; a target body property data determination unit used for determining target body property data of the target first user based on the first database; an inventory determination unit used for determining whether inventories of target models that match the target body property data exists in business objects in the first business object information set; and a business object information provision unit used for providing business object information to the client of the target first user based on a determination result.", "18.The apparatus of claim 17, wherein the target body property data determination unit is used for extracting the target body property data of the target first user in corresponding reference dimensions of the body property data from the first database based on categories to which the business objects in the first business object information set belong and pre-established correspondence relationships between the categories and the reference dimensions.", "19.The apparatus of claim 17, wherein the inventory determination unit comprises: a target model determination subunit used for determining the target models of the business object in the first business object information set that match the body property data of the first user; and a determination subunit used for determining whether the target models of the business objects are in stock by accessing a server of an inventory center.", "20.The apparatus of claim 19, further comprising a second database creation unit used for pre-establishing a second database, wherein the second database is used for storing first correspondence relationships between the models of the business objects and body property data ranges, each business object category corresponds to a different first correspondence relationship, and dimensions of the body property data are different in different first correspondence relationships, wherein the target model determination subunit comprises: a target category determination subunit used for determining a target category to which the business object belong for the business objects in the first business object information set; a target first correspondence relationship determination subunit used for determining a first correspondence relationship corresponding to the target category; and a first target model determination subunit used for setting models corresponding to a target body property data range as the matched target models when the target body property data is located in the target body property data range in the first correspondence relationship." ], [ "<SOH> BACKGROUND <EOH>An e-commerce sales platform provides business objects to buying users in a number of different manners, which include browsing according to categories triggered by a user, conducting searches according to search criteria, or providing recommendations according to user preferences triggered by a server, etc.", "A buying user can select one that is of interest from a page that includes a list of link information of multiple business objects for performing operations such as making a purchase, saving in a collection, etc.", "Some business objects possess a model attribute.", "When selecting this type of business object, a user generally also needs to select a model that is suitable therefor, in addition to a style of the business object, for example.", "Examples include bra, shoes, jeans, cosmetics, etc.", "In existing technologies, links of business objects are usually displayed in a page of a business object list.", "Furthermore, for the sake of providing convenience to users for viewing, a link is generally formed by two parts.", "One part is an image (e.g., a thumbnail image of a descriptive image of an associated business object).", "Another part of information is textual information such as a title, sales volume, etc.", "A user can select a style that is of interest thereto using these link images or link texts as a reference basis.", "Specific models are displayed in a detailed page of a business object that is redirected into after a buying user selects a certain link in a list page, from which the user makes a selection.", "After selecting a model that is needed, the buying user can perform further operations such as making a purchase, adding into a “shopping cart”, etc.", "However, the following situations usually occur in the existing technologies.", "After selecting a certain business object in a list page and attempting to select a model in a detailed page thereof, a buying user discovers that no suitable model exists, or a suitable model is out of stock, and thus cannot make a purchase.", "In this case, the buying user can only return to the list page to select other business object.", "This apparently wastes the time of the buying user, results in poor efficiency and affects the experience of the user.", "From the perspective of a system, switching between pages repeatedly by a user would occupy resources of the system, and increase an access pressure on a server." ], [ "<SOH> SUMMARY <EOH>This Summary is provided to introduce a selection of concepts in a simplified form that are further described below in the Detailed Description.", "This Summary is not intended to identify all key features or essential features of the claimed subject matter, nor is it intended to be used alone as an aid in determining the scope of the claimed subject matter.", "The term “techniques,” for instance, may refer to device(s), system(s), method(s) and/or processor-readable/computer-readable instructions as permitted by the context above and throughout the present disclosure.", "The present disclosure provides methods and apparatuses for providing information of a business object, which can reduce the waster of network resources caused by a transmission of invalid information, and improve the effectiveness of information displayed in a list interface of a client.", "The present disclosure provides the following technical solutions.", "A method for providing information of a business object, includes pre-establishing a first database by a server, the first database being used for storing body property data of first users; determining a first business object information set for a client of a target first user; determining target body property data of the target first user based on the first database; determining whether an inventory of a target model that matches the target body property data exists in business objects in the first business object information set; and providing business object information to the client of the target first user based on a determination result.", "A method for providing information of a business object, includes receiving business object information from a server by a first user client, the business object information being determined by the server using a way including pre-establishing a first database by the server, the first database being used for storing body property data of first users, determining a first business object information set for a client of a target first user; determining target body property data of the target first user based on the first database, determining whether an inventory of a target model that matches the target body property data exists in business objects in the first business object information set, and providing business object information to the first user client based on a determination result; and generating display content in a list display page based on the received business object information.", "An apparatus for providing information of a business object, includes a first data database creation unit used for pre-establishing a first database by a server, the first database being used for storing body property data of first users; a first set determination unit used for determining a first business object information set for a client of a target first user; a target body property data determination unit used for determining target body property data of the target first user based on the first database; an inventory determination unit used for determining whether an inventory of a target model that matches the target body property data exists in business objects in the first business object information set; and a business object information provision unit used for providing business object information to the client of the target first user based on a determination result.", "An apparatus for providing information of a business object, includes an information receiving unit used for receiving business object information from a server by a first user client, the business object information being determined by the server using a way including pre-establishing a first database by the server, the first database being used for storing body property data of first users, determining a first business object information set for a client of a target first user; determining target body property data of the target first user based on the first database, determining whether an inventory of a target model that matches the target body property data exists in business objects in the first business object information set, and providing business object information to the first user client based on a determination result; and a display content generation unit used for generating display content in a list display page based on the received business object information.", "According to the embodiments provided by the present disclosure, the present disclosure discloses the following technical advantages.", "Using the embodiments of the present disclosure, body property data of first users can be stored in advance.", "In this way, when a business object information set is provided to a first user, body property data of the user can first be matched with models of business objects, and a determination is made as to whether a matched model of a business object is in stock.", "Business object information can thereby be provided based on a determination result.", "For example, only business object information of matched models that are in stock is provided to a client of the first user.", "This can reduce the waste of network resources caused by transmission of invalid information.", "Furthermore, the effectiveness of information displayed in a list interface of a client is improved.", "This is especially true in a situation where browsing is performed in a small-screen device such as a mobile device.", "Since a number of business objects that are displayed in each screen are limited, the improvement in the effectiveness of information is more meaningful.", "Apparently, any product implementing the present disclosure does not need to achieve all of the above advantages at the same time." ], [ "CROSS REFERENCE TO RELATED PATENT APPLICATIONS This application claims priority to and is a continuation of PCT Patent Application No.", "PCT/CN2016/089306 filed on 8 Jul.", "2016, and is related to and claims priority to Chinese Patent Application No.", "201510425231.1, filed on 17 Jul.", "2015, entitled “Method and Apparatus for Providing Business Object Information,” which are hereby incorporated by reference in their entirety.", "TECHNICAL FIELD The present disclosure relates to the technological field of information processing of business objects, and particularly to methods and apparatuses for providing business object information.", "BACKGROUND An e-commerce sales platform provides business objects to buying users in a number of different manners, which include browsing according to categories triggered by a user, conducting searches according to search criteria, or providing recommendations according to user preferences triggered by a server, etc.", "A buying user can select one that is of interest from a page that includes a list of link information of multiple business objects for performing operations such as making a purchase, saving in a collection, etc.", "Some business objects possess a model attribute.", "When selecting this type of business object, a user generally also needs to select a model that is suitable therefor, in addition to a style of the business object, for example.", "Examples include bra, shoes, jeans, cosmetics, etc.", "In existing technologies, links of business objects are usually displayed in a page of a business object list.", "Furthermore, for the sake of providing convenience to users for viewing, a link is generally formed by two parts.", "One part is an image (e.g., a thumbnail image of a descriptive image of an associated business object).", "Another part of information is textual information such as a title, sales volume, etc.", "A user can select a style that is of interest thereto using these link images or link texts as a reference basis.", "Specific models are displayed in a detailed page of a business object that is redirected into after a buying user selects a certain link in a list page, from which the user makes a selection.", "After selecting a model that is needed, the buying user can perform further operations such as making a purchase, adding into a “shopping cart”, etc.", "However, the following situations usually occur in the existing technologies.", "After selecting a certain business object in a list page and attempting to select a model in a detailed page thereof, a buying user discovers that no suitable model exists, or a suitable model is out of stock, and thus cannot make a purchase.", "In this case, the buying user can only return to the list page to select other business object.", "This apparently wastes the time of the buying user, results in poor efficiency and affects the experience of the user.", "From the perspective of a system, switching between pages repeatedly by a user would occupy resources of the system, and increase an access pressure on a server.", "SUMMARY This Summary is provided to introduce a selection of concepts in a simplified form that are further described below in the Detailed Description.", "This Summary is not intended to identify all key features or essential features of the claimed subject matter, nor is it intended to be used alone as an aid in determining the scope of the claimed subject matter.", "The term “techniques,” for instance, may refer to device(s), system(s), method(s) and/or processor-readable/computer-readable instructions as permitted by the context above and throughout the present disclosure.", "The present disclosure provides methods and apparatuses for providing information of a business object, which can reduce the waster of network resources caused by a transmission of invalid information, and improve the effectiveness of information displayed in a list interface of a client.", "The present disclosure provides the following technical solutions.", "A method for providing information of a business object, includes pre-establishing a first database by a server, the first database being used for storing body property data of first users; determining a first business object information set for a client of a target first user; determining target body property data of the target first user based on the first database; determining whether an inventory of a target model that matches the target body property data exists in business objects in the first business object information set; and providing business object information to the client of the target first user based on a determination result.", "A method for providing information of a business object, includes receiving business object information from a server by a first user client, the business object information being determined by the server using a way including pre-establishing a first database by the server, the first database being used for storing body property data of first users, determining a first business object information set for a client of a target first user; determining target body property data of the target first user based on the first database, determining whether an inventory of a target model that matches the target body property data exists in business objects in the first business object information set, and providing business object information to the first user client based on a determination result; and generating display content in a list display page based on the received business object information.", "An apparatus for providing information of a business object, includes a first data database creation unit used for pre-establishing a first database by a server, the first database being used for storing body property data of first users; a first set determination unit used for determining a first business object information set for a client of a target first user; a target body property data determination unit used for determining target body property data of the target first user based on the first database; an inventory determination unit used for determining whether an inventory of a target model that matches the target body property data exists in business objects in the first business object information set; and a business object information provision unit used for providing business object information to the client of the target first user based on a determination result.", "An apparatus for providing information of a business object, includes an information receiving unit used for receiving business object information from a server by a first user client, the business object information being determined by the server using a way including pre-establishing a first database by the server, the first database being used for storing body property data of first users, determining a first business object information set for a client of a target first user; determining target body property data of the target first user based on the first database, determining whether an inventory of a target model that matches the target body property data exists in business objects in the first business object information set, and providing business object information to the first user client based on a determination result; and a display content generation unit used for generating display content in a list display page based on the received business object information.", "According to the embodiments provided by the present disclosure, the present disclosure discloses the following technical advantages.", "Using the embodiments of the present disclosure, body property data of first users can be stored in advance.", "In this way, when a business object information set is provided to a first user, body property data of the user can first be matched with models of business objects, and a determination is made as to whether a matched model of a business object is in stock.", "Business object information can thereby be provided based on a determination result.", "For example, only business object information of matched models that are in stock is provided to a client of the first user.", "This can reduce the waste of network resources caused by transmission of invalid information.", "Furthermore, the effectiveness of information displayed in a list interface of a client is improved.", "This is especially true in a situation where browsing is performed in a small-screen device such as a mobile device.", "Since a number of business objects that are displayed in each screen are limited, the improvement in the effectiveness of information is more meaningful.", "Apparently, any product implementing the present disclosure does not need to achieve all of the above advantages at the same time.", "BRIEF DESCRIPTION OF THE DRAWINGS In order to describe the technical solutions of the embodiments of the present disclosure in a better manner, accompanying drawings that are needed by the embodiments are briefly described herein.", "Apparently, the accompanying drawings described herein merely represent some embodiments of the present disclosure.", "One of ordinary skill in the art can also obtain other drawings using these accompanying drawings without making any creative effort.", "FIG.", "1 is a flowchart of a method provided by the embodiments of the present disclosure.", "FIG.", "2-1 is a schematic diagram of a list page of a client provided by the embodiments of the present disclosure.", "FIG.", "2-2 is a schematic diagram of another list page of a client provided by the embodiments of the present disclosure.", "FIG.", "3 is a flowchart of another method provided by the embodiments of the present disclosure.", "FIG.", "4 is a schematic diagram of an apparatus provided by the embodiments of the present disclosure.", "FIG.", "5 is a schematic diagram of another apparatus provided by the embodiments of the present disclosure.", "DETAILED DESCRIPTION The technical solutions of the embodiments of the present disclosure are described in a clear and comprehensive manner in conjunction with the accompanying drawings of the embodiments of the present disclosure.", "Apparently, the described embodiments merely represent some and not all of the embodiments.", "Based on the embodiments in the present disclosure, all other embodiments that are obtained by one of ordinary skill in the art shall fall in the scope of protection of the present disclosure.", "During implementation of the embodiments of the present disclosure, the inventors of the present disclosure have noted that if a certain business object does not have a model suitable for a current first user (who can be a buying user in a sales platform, and a selling user or merchant in the sales platform can be called a second user correspondingly) or the suitable model is out of stock, this is actually invalid information if a business object list provides this business object to the buying user.", "Regardless of whether from the perspective of network transmission or from the perspective of the occupancy of display areas when being displayed in a user interface of a client, this type of information is a waste.", "Based on this consideration, body property data of first users, which includes, for example, heights, waistlines, foot lengths, skin types of the first users, etc., can be stored in advance in the embodiments of the present disclosure.", "In this way, when business object information is provided to a first user, business object information for models that are suitable for the first user and are in stock can first be selected based on body property data of the first user, and this type of information is then provided to the first user.", "As such, the effectiveness of business object information that is provided to the first user is improved, and the waste of resources caused by invalid information is reduced.", "The embodiments of the present disclosure are first described herein from the perspective of a server.", "First Embodiment Referring to FIG.", "1, this first embodiment provides a method 100 for providing information of a business object.", "The method 100 may include the following operations.", "At S102, a server pre-establishes a first database, the first database being used for storing body property data of first users.", "The first database is mainly used for storing the body property data of the first users, which, in implementations, may be like the one shown in Table 1, for example.", "TABLE 1 User Height Waist Upper chest Lower chest Foot length ID (cm) (cm) measurement (cm) measurement (cm) (cm) Skin type User A 160 57 85 75 24 Oily User B 165 60 88 77 26 Dry .", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", "The above first database can be obtained in a number of different manners.", "For example, in one approach, this can be obtained from information such as user information inputted by the first users.", "Apparently, data that can be obtained is different according to differences in completeness of the information inputted by the users.", "Alternatively, in another approach, a user usually inputs body property data thereof when inputting comment information for a business object purchased thereby (for example, inputting comment information for a certain pairs of jeans), a system can provide an option of operation for inputting information such as waistline, etc., to a first user.", "In this way, if needing to share details of his/her buying experience to other first users, a certain first user can input data about his/her waistline through this option of operation.", "As such, this information has a higher reference value for the other first users.", "In this situation, body property data related to the first user may exist in comment information database, from which this type of data can be extracted.", "In another implementation, since some transaction platforms also provide a function to communicate with customer service personnel of second users to a first user, the first user can communicate with customer service personnel of a second user regarding questions such as model selection before selecting a specific business object.", "During this process, the first user may describe body property data thereof.", "For example, when purchasing a certain pair of jeans, a first user may describe his/her waist size, and ask customer service which model he/she needs to buy, etc.", "A server can store this type of conversation data.", "Therefore, body property data of first users can be extracted from this type of conversation data that is stored in the server.", "Apparently, in these foregoing implementations, the body property data of the first users that is collected may be relatively scattered.", "Therefore, a number of different types of data sources can be combined to extract multiple pieces of body property data.", "For example, data about a waist size of a certain first user is extracted from historical comment information, and data about skin type of this first user is extracted from historical conversation data of customer service personnel of a second user, etc.", "Additionally, an option of operation for submitting body property data needed by the embodiments of the present disclosure may further be provided to the first users.", "For example, the option of operation may be provided in an interface such as “configuration”.", "As such, a first user can input and submit various pieces of body property data through the option of operation.", "At S104, first business object information set is determined for a client of a target first user.", "The first business object information set determined by the server can be configured according to specific business scenarios.", "For example, in a scenario when a user performs browsing according to categories, a set formed by business object information that possesses category tags specified by the user can be provided.", "An example includes providing a set of business objects of long dresses, etc.", "Alternatively, when a user inputs a keyword for conducting a search, a set formed by business object information corresponding to the keyword can be provided.", "Alternatively, during a process of actively providing recommendation, the server obtains preference information of a user from an analysis based on historical purchases and browsing history, etc., of the user, and provides to the user a set that is formed by business object information of interest to the user.", "How to obtain specific business object information sets under various specific scenarios can be referenced to the description of existing technologies, and is not described in detail herein.", "At S106, target body property data of the target first user is determined based on the first database.", "After determining the first business object set and before returning specific information to the client of the first user using data in the first business object information set, target body property data of the target first user can also be determined first based on the first database at S102.It should be noted that the database may store a plurality of pieces of body property data (i.e., body property data in multiple dimensions, which includes a height, a waist size, an upper chest measurement, a lower chest measurement, etc.)", "for the first user as shown in Table 1.However, for a specific business object, body property data in one or a number of dimensions may need to be referenced when a model is selected.", "Furthermore, dimensions needed to be referenced may be different for different categories of business objects.", "For example, a dimension needed to be referenced may be a waist size for a pair of jeans, and dimensions needed to be referenced may be an upper chest measurement and a lower chest measurement, etc.", "Therefore, in implementations, respective correspondence relationships between categories and reference dimensions of body property data may also be established in advance.", "An example is shown in Table 2 as follows: TABLE 2 Category Reference dimension(s) of body property data Pant Waist size Shoes Foot length Bra Upper chest measurement and lower chest measurement Cosmetics Skin type .", ".", ".", ".", ".", ".", "As such, when determining the target body property data of the target first user, the target body property data of the target first user in corresponding reference dimension(s) can be extracted from the first database based on categories to which specific business objects in the first business object information set belong and the pre-established correspondence relationships between the categories and the reference dimensions of the body property data.", "For example, business objects in a certain first business object set belong to a “pant” category.", "In this case, a corresponding reference dimension that can be determined by querying the above Table 2 is “waist size”.", "As such, specific body property data of the first user in a dimension associated with the waist size can be obtained from Table 1, i.e., a specific waist circumference.", "Business objects in the first business object set may belong to a same category, or may belong to different categories.", "Information of a category to which a business object belongs can be determined in a number of different ways.", "For example, in a most straightforward approach, each business object generally carries attribute information about a category to which it belongs.", "This information is stored in a business object information database, or embedded in description information of the business object by means of a tag.", "Therefore, the category to which the business object belongs can be directly determined based on this type of information.", "Alternatively, in another implementation, since the first business object information set may be obtained according to a browsing request submitted by the first user and a specific category may be selected before sending the browsing request (i.e., what is sent by the client of the first user is a browsing request directed to browsing a specified category), business objects in the first business object information set usually all belong to this specified category.", "Therefore, the category to which the business objects in the set belong can be directly determined based on the specified category included in the browsing request.", "Furthermore, the first business object information may also be determined based on a search request of the first user.", "A search request sent by a client of a first user usually also includes a search keyword, and this search keyword may generally have an association with a category.", "Furthermore, business objects in a first business object information set that are obtained for this search request are all related to this search keyword.", "Therefore, category information corresponding to the search keyword included in the search request can further be determined first, and this category information is determined to be a target category to which the business objects in the set belong.", "For example, a certain search keyword is “jeans”, and a corresponding category may be determined to be “pants”.", "Therefore, a category to which business objects in a business object set are determined to be “pants”.", "In short, using the latter two methods, a category to which business objects can be determined without the need of querying tags of the business objects one by one, thus helping to improve the efficiency of processing.", "At S108, a determination is made as to whether model(s) matching the target body property data is/are in stock for the business objects in the first business object information set.", "After the first business object information set and the target body property data of the target first user are determined, a determination can be made as to whether target models matching the target body property data are in stock for the business objects in the set.", "For example, for a first user searching for a pair of jeans, business objects in a first business object set may satisfy this criterion of belonging to a category of jeans.", "However, whether models thereof satisfy the current need of the first user is not sure.", "Therefore, in the embodiments of the present disclosure, a determination may first be made.", "In implementations, this operation can be divided into two sub-operations for implementation.", "First, target models of the business object in the set that match the body property data of the current first user are determined.", "A determination of whether the target models of the business objects are in stock is then made by such method as accessing an inventory center server, for example.", "For instance, a certain first user needs to search for a pair of jeans.", "A waist size of the first user is 54 cm.", "For a certain specific business object, a model matching with this waist data is “size 26”.", "A query may then be made to an inventory center server about whether an inventory of “size 26” of the business object exists.", "If affirmative, this business object satisfies the need of the current first user with respect to model, for example.", "In order to facilitate understanding, distinctions and relations between models of body property data of users and business objects are described first.", "Body property data of a user is generally data obtained for the user through measurements, for example.", "A tool for measuring a length in a real-world application is generally a metric scale.", "Therefore, body property data obtained from measurements generally uses “cm” as a unit.", "For example, in Table 1 described above, body property data such as a height, a waist size, a chest size, a foot length, etc., uses “cm” as a unit.", "Furthermore, specific body property data related to a skin type can generally be obtained using related tools, and this body property data generally includes “oily”, “dry”, “mixed”, etc.", "A model of a business object is determined based on industry standard, for example.", "Representations of models of business objects of different categories are different.", "For example, a model of a bra is formed by two parts: a bottom circumference size and a cup size.", "The bottom circumference size is generally represented by a length of chest size, and the cup size is generally represented by English capital letter such as A, B, C. Examples are 70A, 75B, etc.", "A size of shoe type is represented by a size of shoes, such as 35-42, etc.", "A model of jeans has a number of different representations.", "For example, “L” represents large, “M” represents medium, “S” represents” small, “XL” represents extra large, and “XXL” represents extra extra large, etc.", "Alternatively, the model of the jeans can also be represented by a suitable height, such as 155 cm, 160 cm, etc.", "Alternatively, the model of the jeans may be represented by a waist size.", "In this case, a unit for the waist size is an inch, e.g., “26” represents that the waist size is “1.9 m” in length, “27” represents that the waist size is “2.0 m”, and “28” represents that the waist size is “2.1 m”, etc.", "A model of cosmetics is a moisturizing type, a refreshing type, etc.", "As can be seen, the meanings represented by the models of the body property data of the users and the business objects are different.", "In the first database as shown in Table, body property data of a user generally uses cm as a unit.", "On the other hand, a model of a business object is generally not represented using cm, and is represented in other forms.", "However, these two have a certain relation.", "For example, a user having a waist size of 54 cm is usually suitable to wear pants of “size 26”, and a user of a dry skin type is relatively suitable to use a cosmetics of a moisturizing type.", "Therefore, at S108, models of the business objects in the set that match with the body property data of the current first user can also be determined.", "When implemented, a number of different implementations can exist.", "For example, in an implementation, business objects of a same category usually have a standard or universal characteristic with respect to a model.", "For example, if different jeans have a same “size 26”, a first user having a waist size of about 54 cm is suitable thereto.", "Therefore, in this implementation, a second database can be established in advance.", "The second database is used for storing first correspondence relationships between models of business objects and body property data ranges, and each business object category corresponds to a different first correspondence relationship.", "In different first correspondence relationships, dimensions of body property data may be different.", "An example is shown in Table 3.TABLE 3 Business object Body property Body property category Model data dimension data range Pants 26 Waist size 54 cm 27 Waist size 55 cm .", ".", ".", ".", ".", ".", ".", ".", ".", "Cosmetics Moisturizing type, Skin type Dry refreshing, amino acid Refreshing Skin type Oily .", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", "In this way, for a certain business object in the set, when the models matching the body property data of the current first user is determined, a target category to which the business object belongs can first be determined, e.g., the target category is pants.", "A target first correspondence relationship corresponding to the target category is then determined.", "For example, the target first correspondence relationship corresponding to the category of pants is shown in Table 3.A determination may then be made as to whether the target body property data of the current first user is located within a certain body property data range in the target first correspondence relationship.", "For example, if the waist size of the current first user is 54, a first row in Table 3 is matched therewith, i.e., a body property data range in the first row is a successfully matched target body property data range.", "A model corresponding to the target body property data range may then be determined as the matched target model, i.e., determining that the target model that matches with the waist size of the current first user is “size 26”.", "The second database as shown in Table 3 can be pre-established based on information such as industry standard of various categories.", "Furthermore, in implementations, in order to avoid a structure of the database to be too complicated, first correspondence relationships corresponding to various categories can also be recorded in different second databases.", "Furthermore, how to determine respective categories to which business objects in a set belong can be referenced to the description of S106, and is not repeatedly described in detail herein.", "The above is an implementation of creating a correspondence relationship for a same category, and has advantages such as having a high efficiency occupying less storage resources, and facilitating queries.", "However, the following situations may also exist in a real application.", "A situation in which sizes of specific business objects may not be very standardized in reality, though models in different industries possess standards thereof.", "For example, sizes of some business objects may be biased—too large or too small.", "In these situations, situations such as discrepancies may occur if models of business objects matching the body property data are simply determined according to categories.", "Therefore, in another implementation, a third database may also be pre-established.", "The third database is used for storing second correspondence relationships between models of business objects and body property data ranges.", "Each business object corresponds to a second correspondence relationship thereof.", "For example, the third database may be like the one as shown in Table 4.TABLE 4 Business object Body property Body property id Model data dimension data range Id1 26 Waist size 39 cm 27 Waist size 40 cm .", ".", ".", ".", ".", ".", ".", ".", ".", "Id2 26 Waist size 38 cm 27 Waist size 39 cm .", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", ".", "As can be seen from Table 4 above, although id1 and id2 both belong to a category of pants, body property data ranges corresponding to a same model are not the same.", "In other words, of pants of “size 26” having id1 are suitable for a user having a waist size of 39 cm, and a size of this type of pants having id2 is relatively small, and “size 26” is only suitable for a user having a waist size of 38 cm.", "In this way, for a certain business object, when determining models that match with the target body property data of the current first user, a target second correspondence relationship corresponding to the target business objects can be determined first by querying Table 4 as described above, for example.", "For example, a certain business object is id1, a corresponding second correspondence relationship is as shown in Table 4.When the target body property data is located in a certain target body property data range in the target second correspondence relationship, a model corresponding to the target body property data range can be determined to be the target model.", "For example, the waist size of the current first user is 39 cm, a target model that matches therewith can be determined to be “size 26”.", "Similarly, for another business object in the set, for example, id2, a matched model is determined to be “size 27” for the current first user having the waist size of 39 cm.", "As can be seen, using the second implementation as described above, although an amount of data that needs to be stored is increased, the accuracy of matching is improved, thus helping the user to determine information of more suitable model and further improving the effectiveness of business object information.", "The third database as described above can be created in a number of different ways, for example, in an implementation, extraction and collection can be made from data such as detailed description information of business objects published by second users, comment information of first users, conversations between the first users and customer personnel of the second users.", "Alternatively, in another implementation, an option of operation used for uploading information of a second correspondence relationship as described above may also be provided to a second user when the second user published business object information.", "The specific second correspondence relationship that is uploaded by the second user according to the business object can be directly stored by the server.", "This can improve the data accuracy.", "In short, after the target body property data of the current target first user and the target models that match the target body property data for the business objects in the first business object information are determined, respective inventories of corresponding models of the business objects can be determined.", "In implementations, information about inventories of business objects is generally stored in a server of a designated inventory center.", "Therefore, a query request can be sent to the server of the inventory center, and inventory information of the corresponding models of the business objects is returned from the server of the inventory center.", "At S110, business object information is provided to the client of the target first user based on a determination result.", "Specifically, a number of different types of implementations can exist for providing business objects based on a determination result.", "For example, if a corresponding target model of a certain business object is in stock (e.g., an inventory of “size 26” of a certain jeans matching with the current first user exists), this business object is proved to be valid for the first user.", "If the first user is interested in this business object, a model problem will not lead to a failure of the first user to make a purchase.", "Therefore, the business object can be provided to the first user.", "Moreover, if a corresponding model of a certain business object is out of stock, two situations may exist.", "One may be that the model of the business object was not produced during manufacture.", "Another situation is that the target model has been sold out and is no longer provided for sales service.", "Even if information of this business object is provided to the first user, the first user is not able to purchase a model that satisfies his/her need, and therefore the information of the business object is not provided to the first user.", "In other words, only business objects having target models being in stock form a second business object set, and display content in a list page is provided to the client using the second business object set.", "Apparently, in another implementation, former business objects in the first business object set can also be provided to the client of the first user, but business objects with models being out of stock may be labeled.", "As such, the client can add certain identifiers to these business objects with models being out of stock in the list page, for example, displaying in a form such as text (e.g., “sold out”, “unavailable”, etc.)", "to prompt to the first user that he/she may not necessarily enter into purchase pages thereof to make a purchase, etc.", "In implementations, when returning the business object information to the client of the first user, the server may also return model information to the client for the business objects with the models being in stock.", "The client can display this type of model information in the list page directly, to enable the first user to determine models of business objects that are suitable for him/her more intuitively.", "A number of different ways may exist for providing this type of model information.", "For example, in an implementation, since information of links of various business objects are generally provided when the server provides display content in the list page to the client of the first user, and the links generally include two parts (images and texts), target model information corresponding to the business objects can be added into respective texts of the links.", "As such, the client can present this type of target model information in the respective texts of the links.", "For example, referring to FIG.", "2-1, when a first user searches for “bra”, texts of links of various business objects that are returned may include information such as “[recommend: 75B]”, “[recommend: 80B]”, etc.", "For another example, referring to FIG.", "2-2, when a first user searches for “jeans”, texts of links of various business objects that are returned may include information such as “[recommend: 2.3 meter]”, “[recommend: 2.2 meter]”, etc.", "Furthermore, in a situation in which all business objects in a business object set belong to a same category, reference dimension(s) of body property data related to this category and body property data value(s) of a current first user in the reference dimension(s) are provided to a client of the first user, to allow the client of the first user to display in a list page.", "In this case, an option of operation for modifying this body property data may also be provided.", "For example, label 202 in FIG.", "2-1 displays “my measurements: upper chest size 85 cm, lower chest size 75 cm”, and a button with an “edit” label may also be displayed.", "This button is an option of operation for modifying the body property data.", "If the current first user notes that the displayed information is incorrect, or the body property data thereof has changed, modification can be made through this option.", "After modification, the client of the first user can upload the modified body property data to the server.", "The server updates the business object information that is provided based on the modified body property data.", "The server may also update the body property data of the first user that is stored in the first database, and then provide business object information using the updated body property data.", "Using the embodiments of the present disclosure, body property data of first users can be stored in advance.", "In this way, when a business object information set is provided to a first user, body property data of the user can first be matched with models of business objects, and a determination is made as to whether a matched model of a business object is in stock.", "Business object information can thereby be provided based on a determination result.", "For example, only business object information of matched models that are in stock is provided to a client of the first user.", "This can reduce the waste of network resources caused by transmission of invalid information.", "Furthermore, the effectiveness of information displayed in a list interface of a client is improved.", "This is especially true in a situation where browsing is performed in a small-screen device such as a mobile device.", "Since a number of business objects that are displayed in each screen are limited, the improvement in the effectiveness of information is more meaningful.", "Second Embodiment The second embodiment corresponds to the first embodiment, and provides a method 300 for providing business object information from the perspective of a client of a first user.", "Referring to FIG.", "3, the method 300 may include the following operations.", "At S302, a first user client receives business object information from a server, the business object information being determined by the server using a way as follows: pre-establishing a first database by the server, the first database being used for storing body property data of first users, determining a first business object information set for a client of a target first user; determining target body property data of the target first user based on the first database, determining whether inventories of target models that match with the target body property data exist in business objects in the first business object information set, and providing business object information to the first user client based on a determination result.", "At S304, display content in a list display page is generated based on the received business object information.", "In implementations, the information returned by the server further includes the models corresponding to the business objects.", "In this case, information of the models may also be displayed in the list display page.", "Specifically, the information of the models can be displayed in texts of a links of the business objects.", "Furthermore, the information returned by the server may further include target body property data of the target first user with respect to reference dimension(s) corresponding to a same target category when the business objects in the first business object set belong to the target category.", "In this case, the client may further display the target body property data of the target first user with respect to the reference dimension(s) that correspond(s) to the target category in the list display page.", "Furthermore, an option of operation for editing the body property data with respect to the reference dimension(s) in the list page.", "When modified body property data is received through this option of operation, the modified body property data is uploaded to the server, to enable the server to update provided business object information based on the modified body property data.", "The second embodiment corresponds to the first embodiment.", "Details of related implementations can be referenced to the description of the first embodiment, and are not repeatedly described herein.", "In correspondence with the first embodiment, the embodiments of the present disclosure further provides an apparatus 400 for providing business object information, which is applied in a server.", "Referring to FIG.", "4, the apparatus 400 may include one or more processors 402, an input/output (I/O) interface 404, a network interface 406, and memory 408.The memory 408 may include a form of computer readable media such as a volatile memory, a random access memory (RAM) and/or a non-volatile memory, for example, a read-only memory (ROM) or a flash RAM.", "The memory 408 is an example of a computer readable media.", "The computer readable media may include a volatile or non-volatile type, a removable or non-removable media, which may achieve storage of information using any method or technology.", "The information may include a computer-readable instruction, a data structure, a program module or other data.", "Examples of computer storage media include, but not limited to, phase-change memory (PRAM), static random access memory (SRAM), dynamic random access memory (DRAM), other types of random-access memory (RAM), read-only memory (ROM), electronically erasable programmable read-only memory (EEPROM), quick flash memory or other internal storage technology, compact disk read-only memory (CD-ROM), digital versatile disc (DVD) or other optical storage, magnetic cassette tape, magnetic disk storage or other magnetic storage devices, or any other non-transmission media, which may be used to store information that may be accessed by a computing device.", "As defined herein, the computer readable media does not include transitory media, such as modulated data signals and carrier waves.", "In implementations, the memory 408 may include program units 410 and program data 412.The program units 410 may include a first data database creation unit 414 used for pre-establishing a first database by a server, the first database being used for storing body property data of first users; a first set determination unit 416 used for determining a first business object information set for a client of a target first user; a target body property data determination unit 418 used for determining target body property data of the target first user based on the first database; an inventory determination unit 420 used for determining whether an inventory of a target model that matches the target body property data exists in business objects in the first business object information set; and a business object information provision unit 422 used for providing business object information to the client of the target first user based on a determination result.", "The target body property data determination unit 418 is used for extracting the target body property data of the target first user in corresponding body property data reference dimensions from the first database based on respective categories to which the business objects in the first business object information set belong and correspondence relationships between the categories and the reference dimensions.", "In implementations, the inventory determination unit 420 may include a target model determination subunit 424 used for determining models of the business objects in the first business object information set that match with the body property data of the current first user; and a determination subunit 426 used for determining whether inventories of the models of the business objects exist by accessing a server of an inventory center.", "In implementations, the apparatus may further include a second database creation unit 428 used for pre-establishing a second database, the second database being used for storing first correspondence relationships between models of business objects and body property data ranges, wherein each business object category corresponds to a different first correspondence relationship, and dimensions of the body property data are different in different first correspondence relationships.", "The target model determination subunit 424 includes a target category determination subunit 430 used for determining target categories to which the business objects belong for the business objects in the first business object information set; a target first correspondence determination subunit 432 used for determining respective first correspondence relationships corresponding to the target categories; and a first target model determination subunit 434 used for setting models corresponding to target body property data ranges to be matched target models when the target property data is located in the target body property data ranges of the target first correspondence relationships.", "The first set determination unit 416 is used for determining the first business object information set based on information of a designated category included in a browsing request when receiving the browsing request for browsing the designated category from the client of the target first user.", "The target category determination subunit 430 is used for setting the information of the designated category included in the browsing request as the target category to which the business objects belong.", "Alternatively, the first set determination unit 416 is used for determining the first business object information set based on a search keyword included in a search request when receiving the search request from the client of the target first user.", "The target category determination subunit 430 is used for determining category information corresponding to the search keyword included in the search request and setting the category information as the target category to which the business objects belong.", "In another implementation, the apparatus 400 may further include a third database creation unit 436 used for pre-establishing a third database, the third database being used for storing second correspondence relationships between the models of the business objects and the body property data ranges, wherein the business objects individually correspond to the second correspondence relationships thereof.", "In this case, the target model determination subunit 424 includes a target second correspondence relationship determination subunit 438 used for determining target second correspondence relationships corresponding to the target business objects for the target business objects in the first business object information set; and a second target model determination subunit 440 used for setting models corresponding to target body property data ranges to be matched target models when the target property data is located in the target body property data ranges of the target second correspondence relationships.", "In implementations, the business object information provision unit 422 includes a second business object set determination subunit 442 used for forming a second business object set using business objects with target models being in stock; and a provision subunit 444 used for providing the display content in the list page to the client using the second business object set.", "In order to provide more intuitive information, the apparatus 400 may further include a target model information provision 446 unit used for providing information of the target models for the business objects with the target models being in stock, to enable the client of the first user to display the information of the target models of the business objects in the list page.", "Specifically, the target model information provision unit 446 is used for adding the information of the target models in texts of respective links of the business objects for the business objects with the target models being in stock.", "Furthermore, the apparatus 400 may also include a body property data provision unit 448 used for providing target body property data of the target first user in reference dimensions corresponding to a target category to the client of the first user when the business objects in the first business object set all belong to this same target category, to allow the client of the first user to display thereof in the list page.", "In correspondence with the second embodiment, the embodiments of the present disclosure also provide an apparatus 500 for providing business object information, which is applied in a client of a first user.", "Referring to FIG.", "5, the apparatus 500 may include one or more processors 502, an input/output (I/O) interface 504, a network interface 506, and memory 508.The memory 508 may include a form of computer readable media as described above.", "In implementations, the memory 508 may include program units 510 and program data 512.The program units 510 may include an information receiving unit 514 used for receiving business object information from a server by a first user client, the business object information being determined by the server using a way including pre-establishing a first database by the server, the first database being used for storing body property data of first users, determining a first business object information set for a client of a target first user; determining target body property data of the target first user based on the first database, determining whether an inventory of a target model that matches the target body property data exists in business objects in the first business object information set, and providing business object information to the first user client based on a determination result; and a display content generation unit 516 used for generating display content in a list display page based on the received business object information.", "The information returned by the server further includes the models corresponding to the business objects.", "The apparatus 500 further includes a target model information provision unit 518 used for displaying information of the models in the list display page.", "Specifically, the target model information provision unit is used for displaying the information of the models in texts of links of the business objects.", "The information returned by the server may further include target body property data of the target first user with respect to reference dimension(s) corresponding to a same target category when the business objects in the first business object set belong to the target category.", "The apparatus 500 further includes a body property data provision unit 520 used for displaying the target body property data of the target first user with respect to the reference dimension(s) that correspond(s) to the target category in the list display page.", "Furthermore, the apparatus 500 may further include an editing option provision unit 522 used for providing an option of operation for editing the body property data with respect to the reference dimension(s) in the list page; and a modified data uploading unit 524 used for uploading modified body property data to the server when the modified body property data is received through this option of operation, to enable the server to update provided business object information based on the modified body property data.", "Using the embodiments of the present disclosure, body property data of first users can be stored in advance.", "In this way, when a business object information set is provided to a first user, body property data of the user can first be matched with models of business objects, and a determination is made as to whether a matched model of a business object is in stock.", "Business object information can thereby be provided based on a determination result.", "For example, only business object information of matched models that are in stock is provided to a client of the first user.", "This can reduce the waste of network resources caused by transmission of invalid information.", "Furthermore, the effectiveness of information displayed in a list interface of a client is improved.", "This is especially true in a situation where browsing is performed in a small-screen device such as a mobile device.", "Since a number of business objects that are displayed in each screen are limited, the improvement in the effectiveness of information is more meaningful.", "Through the above description of the embodiments, one skilled in the art can understand that the embodiments of the present disclosure can be implemented in a form of software with a necessary universal hardware platform.", "Based on such understanding, the essence of technical solutions of the embodiments of the present disclosure or contributions to the existing technologies may be embodied in a form of a software product.", "The software product may be stored in a non-volatile storage media (such as a CD-ROM, a magnetic disk, an optical drive, etc.", "), and includes instructions that enable a computing device (may be a personal computer, a server, or a network device) to execute each embodiment or a portion of the method of each embodiment of the present disclosure.", "The embodiments of the present disclosure are described in a progressive manner.", "The same or similar portions of the embodiments can be referenced with each other.", "Each embodiment places an emphasis differently from other embodiments.", "Because of being basically similar to the method embodiments, the description of the systems or system embodiments is relatively brief, and can be referenced to related portions of the method embodiments.", "The foregoing systems and system embodiments are merely exemplary.", "Units that are described as separate components may or may not be physically separate.", "A component that is presented as a unit may or may not be a physical unit, i.e., may be located in a single location, or may be distributed among a plurality of network units.", "Some or all of the modules may be selected to implement the purpose of the solution of the present embodiments based on actual needs.", "One of ordinary skill in the art can understand and implement the present disclosure without making any creative effort.", "Methods and apparatuses for providing business object information are described in detail above.", "The present disclosure uses examples to describe the principles and embodiments of the present disclosure.", "The description of the foregoing embodiments is merely used to help understand the methods and concepts of the present disclosure.", "Based on the concepts of the present disclosure, one of ordinary skill in the art can make changes to the specific embodiments and application scopes.", "In short, content of the present specification should not be construed as limitations to the present disclosure.", "The present disclosure may be further understood with clauses as follows.", "Clause 1: A method for providing business object information, comprising: pre-establishing a first database by a server, the first database being used for storing body property data of first users; determining a first business object information set for a client of a target first user; determining target body property data of the target first user based on the first database; determining whether inventories of target models that match the target body property data exists in business objects in the first business object information set; and providing business object information to the client of the target first user based on a determination result.", "Clause 2: The method of Clause 1, wherein determining the target body property data of the target first user based on the first database comprises extracting the target body property data of the target first user in corresponding reference dimensions of the body property data from the first database based on categories to which the business objects in the first business object information set belong and a pre-established correspondence relationships between the categories and the reference dimensions.", "Clause 3: The method of Clause 1, wherein determining whether the inventories of the target models that match the target body property data exists in the business objects in the first business object information set comprises: determining the target models of the business object in the first business object information set that match the body property data of the first user; and determining whether the target models of the business objects are in stock by accessing a server of an inventory center.", "Clause 4: The method of Clause 3, further comprising pre-establishing a second database, wherein the second database is used for storing first correspondence relationships between the models of the business objects and body property data ranges, each business object category corresponds to a different first correspondence relationship, and dimensions of the body property data are different in different first correspondence relationships, wherein determining the target models of the business object in the first business object information set that match the body property data of the first user comprises: determining a target category to which the business object belong for the business objects in the first business object information set; determining a first correspondence relationship corresponding to the target category; and setting models corresponding to a target body property data range as the matched target models when the target body property data is located in the target body property data range in the first correspondence relationship.", "Clause 5: The method of Clause 4, wherein: determining the first business object information set for the client of the target first user comprises determining the first business object information set based on information of a designated category included in a browsing request when receiving the browsing request for browsing the designated category from the client of the target first user, and determining the target category to which the business object belong for the business objects in the first business object information set comprises setting the information of the designated category included in the browsing request as the target category to which the business objects belong.", "Clause 6: The method of Clause 4, wherein: determining the first business object information set for the client of the target first user comprises determining the first business object information set based on a search keyword included in a search request when receiving the search request from the client of the target first user, and determining category information corresponding to the search keyword included in the search request and setting the category information as the target category to which the business objects belong.", "Clause 7: The method of Clause 3, further comprising pre-establishing a third database, the third database being used for storing second correspondence relationships between the models of the business objects and the body property data ranges, wherein the business objects individually correspond to the second correspondence relationships, wherein determining the target models of the business object in the first business object information set that match the body property data of the first user comprises: determining target second correspondence relationships corresponding to the target business objects for the target business objects in the first business object information set; and setting models corresponding to target body property data ranges to be matched target models when the target property data is located in the target body property data ranges of the target second correspondence relationships.", "Clause 8: The method of Clause 1, wherein providing the business object information to the client of the target first user based on the determination result comprises: forming a second business object set using business objects with target models being in stock; and providing the display content in a list page to the client using the second business object set.", "Clause 9: The method of Clause 1, further comprising providing information of the target models for the business objects with the target models being in stock, to enable the client of the first user to display the information of the target models of the business objects in a list page.", "Clause 10: The method of Clause 9, wherein providing the information of the target models for the business objects with the target models being in stock comprises adding the information of the target models in texts of respective links of the business objects for the business objects with the target models being in stock.", "Clause 11: The method of Clause 1, further comprising providing target body property data of the target first user in reference dimensions corresponding to a target category to the client of the first user when the business objects in the first business object set all belong to the target category, to allow the client of the first user to display thereof in a list page.", "Clause 12: A method for providing business object information, comprising: receiving business object information from a server by a first user client, the business object information being determined by the server using a way including pre-establishing a first database by the server, the first database being used for storing body property data of first users, determining a first business object information set for a client of a target first user; determining target body property data of the target first user based on the first database, determining whether inventories of target models that match the target body property data exists in business objects in the first business object information set, and providing business object information to the first user client based on a determination result; and generating display content in a list display page based on the received business object information.", "Clause 13: The method of Clause 12, wherein the information returned by the server further comprises the models corresponding to the business objects, and the method further comprises displaying information of the models in the list display page.", "Clause 14: The method of Clause 13, wherein displaying the information of the models in the list display page comprises displaying the information of the models in texts of links of the business objects.", "Clause 15: The method of Clause 12, wherein the information returned by the server further comprises target body property data of the target first user with respect to a reference dimension corresponding to a same target category when the business objects in the first business object set belong to the target category, and the method further comprises displaying the target body property data of the target first user in the reference dimension corresponding to the target category in the list display page.", "Clause 16: The method of Clause 15, further comprising: providing an option of operation for editing the body property data in the reference dimension in the list page; and uploading modified body property data to the server when the modified body property data is received through the option of operation, to enable the server to update provided business object information based on the modified body property data.", "Clause 17: An apparatus for providing business object information, which is applied in a server, the apparatus comprising: a first data database creation unit used for pre-establishing a first database by a server, the first database being used for storing body property data of first users; a first set determination unit used for determining a first business object information set for a client of a target first user; a target body property data determination unit used for determining target body property data of the target first user based on the first database; an inventory determination unit used for determining whether inventories of target models that match the target body property data exists in business objects in the first business object information set; and a business object information provision unit used for providing business object information to the client of the target first user based on a determination result.", "Clause 18: The apparatus of Clause 17, wherein the target body property data determination unit is used for extracting the target body property data of the target first user in corresponding reference dimensions of the body property data from the first database based on categories to which the business objects in the first business object information set belong and pre-established correspondence relationships between the categories and the reference dimensions.", "Clause 19: The apparatus of Clause 17, wherein the inventory determination unit comprises: a target model determination subunit used for determining the target models of the business object in the first business object information set that match the body property data of the first user; and a determination subunit used for determining whether the target models of the business objects are in stock by accessing a server of an inventory center.", "Clause 20: The apparatus of Clause 19, further comprising a second database creation unit used for pre-establishing a second database, wherein the second database is used for storing first correspondence relationships between the models of the business objects and body property data ranges, each business object category corresponds to a different first correspondence relationship, and dimensions of the body property data are different in different first correspondence relationships, wherein the target model determination subunit comprises: a target category determination subunit used for determining a target category to which the business object belong for the business objects in the first business object information set; a target first correspondence relationship determination subunit used for determining a first correspondence relationship corresponding to the target category; and a first target model determination subunit used for setting models corresponding to a target body property data range as the matched target models when the target body property data is located in the target body property data range in the first correspondence relationship.", "Clause 21: The apparatus of Clause 20, wherein: the first set determination unit is used for determining the first business object information set based on information of a designated category included in a browsing request when receiving the browsing request for browsing the designated category from the client of the target first user, and the target category determination subunit is used for setting the information of the designated category included in the browsing request as the target category to which the business objects belong.", "Clause 22: The apparatus of Clause 20, wherein: the first set determination unit is used for determining the first business object information set based on a search keyword included in a search request when receiving the search request from the client of the target first user, and the target category determination subunit is used for determining category information corresponding to the search keyword included in the search request and setting the category information as the target category to which the business objects belong.", "Clause 23: The apparatus of Clause 19, further comprising a third database creation unit used for pre-establishing a third database, the third database being used for storing second correspondence relationships between the models of the business objects and the body property data ranges, wherein the business objects individually correspond to the second correspondence relationships, wherein the target model determination subunit comprises: a target second correspondence relationship determination subunit used for determining target second correspondence relationships corresponding to the target business objects for the target business objects in the first business object information set; and a second target determination subunit used for setting models corresponding to target body property data ranges to be matched target models when the target property data is located in the target body property data ranges of the target second correspondence relationships.", "Clause 24: The apparatus of Clause 17, wherein the business object information provision unit comprises: a second business object set determination subunit used for forming a second business object set using business objects with target models being in stock; and a provision subunit used for providing the display content in a list page to the client using the second business object set.", "Clause 25: The apparatus of Clause 17, further comprising a target model information provision unit used for providing information of the target models for the business objects with the target models being in stock, to enable the client of the first user to display the information of the target models of the business objects in a list page.", "Clause 26: The apparatus of Clause 25, wherein the target model information provision unit is used for adding the information of the target models in texts of respective links of the business objects for the business objects with the target models being in stock.", "Clause 27: The apparatus of Clause 17, further comprising a body property data provision unit used for providing target body property data of the target first user in reference dimensions corresponding to a target category to the client of the first user when the business objects in the first business object set all belong to the target category, to allow the client of the first user to display thereof in a list page.", "Clause 28: An apparatus for providing business object information, comprising: an information receiving unit used for receiving business object information from a server by a first user client, the business object information being determined by the server using a way including pre-establishing a first database by the server, the first database being used for storing body property data of first users, determining a first business object information set for a client of a target first user; determining target body property data of the target first user based on the first database, determining whether inventories of target models that match the target body property data exists in business objects in the first business object information set, and providing business object information to the first user client based on a determination result; and a display content generation unit used for generating display content in a list display page based on the received business object information.", "Clause 29: The apparatus of Clause 28, wherein the information returned by the server further comprises the models corresponding to the business objects, and the apparatus further comprises a target model information provision unit used for displaying information of the models in the list display page.", "Clause 30: The apparatus of Clause 28, wherein the target model information provision unit is used for displaying the information of the models in texts of links of the business objects.", "Clause 31: The apparatus of Clause 27, wherein the information returned by the server further comprises target body property data of the target first user with respect to a reference dimension corresponding to a same target category when the business objects in the first business object set belong to the target category, and the apparatus further comprises a body property data provision unit used for displaying the target body property data of the target first user in the reference dimension corresponding to the target category in the list display page.", "Clause 32: The apparatus of Clause 30, further comprising: an editing option provision unit used for providing an option of operation for editing the body property data in the reference dimension in the list page; and a modified data uploading unit used for uploading modified body property data to the server when the modified body property data is received through the option of operation, to enable the server to update provided business object information based on the modified body property data." ] ]
Patent_15872858
[ [ "HANDPIECE ASSEMBLY FOR LASER TREATMENT DEVICE", "Embodiments of the invention include a handpiece system including a detachable cable that can receive at least power, and a detachable cable connector, where the detachable cable connector and detachable cable are reversibly attachable to each other.", "In some embodiments, the system includes an interchangeable laser module, where the laser module and detachable cable connector are reversibly attachable to each other.", "Further, the interchangeable laser module is configured and arranged to receive at least the power via the cable connector when coupled to the cable connector, and to be removed from the detachable cable connector and replaced with another laser module.", "In some embodiments, the system further includes an interchangeable handpiece which is reversibly attachable to the interchangeable laser module.", "Further, the interchangeable handpiece is configured and arranged to be removed from the interchangeable laser module and replaced with another interchangeable handpiece." ], [ "1.A handpiece system comprising: a detachable cable configured and arranged to receive at least power; a detachable cable connector, the detachable cable connector and detachable cable being reversibly attachable to each other; at least one interchangeable laser module, the at least one interchangeable laser module and the detachable cable connector being reversibly attachable to each other, wherein the at least one interchangeable laser module is configured and arranged to receive at least the power via the cable connector when coupled to the cable connector, and to be removed from the detachable cable connector and replaced with another laser module; and at least one interchangeable handpiece, at least one interchangeable handpiece and the at least one interchangeable laser module being reversibly attachable to each other, and wherein the at least one interchangeable handpiece is configured and arranged to be removed from the at least one interchangeable laser module and replaced with at least one other interchangeable handpiece.", "2.The system of claim 1, further comprising a power supply remote from the at least one interchangeable laser module and coupled to the detachable cable at an end of the cable opposite from the cable connector.", "3.The system of claim 1, wherein the at least one interchangeable laser module includes at least one of a laser diode, a diode-pumped solid state laser, a flashlamp-pumped solid state laser, and a light emitting diode.", "4.The system of claim 1, wherein the at least one laser module and the another laser module are configured and arranged to generate electromagnetic energy with wavelengths that differ from each other.", "5.The system of claim 1, further comprising a controller, remote from the at least one laser module.", "6.The system of claim 5, wherein the controller is configured and arranged to be coupled to the at least one laser module using the at least one detachable cable.", "7.The system of claim 5, further comprising a remote controller.", "8.The system of claim 7, wherein the remote controller is operatively coupled to the controller using a wired coupling.", "9.The system of claim 7, wherein the remote controller and controller include wireless circuitry configured and arranged to enable wireless communication between the remote controller and the controller.", "10.The system of claim 2, further comprising a control module coupled or integrated with the power supply.", "11.The system of claim 10, wherein the control module includes a wireless controller configured and arranged to be wirelessly controlled with a smartphone or a tablet computer.", "12.The system of claim 10, wherein the power supply and control module are coupled with or integrated into a dental chair.", "13.The system of claim 12, further comprising at least one display terminal mounted, coupled, or integrated with the dental chair.", "14.The system of claim 13, wherein the at least one display terminal is configured to display information based on one or more sensor signal from a coupled assembly of the handpiece, at least one laser module, and detachable cable connector.", "15.The system of claim 14, further comprising a user interface configured to control signals to the at least one laser module.", "16.The system of claim 1, wherein the detachable cable includes at least one fluid channel configured and arranged to deliver at least one fluid to the handpiece.", "17.The system of claim 1, wherein detachable connector comprises connections including at least one of a laser power control signal connection, fluid intake and output connections, an identification code signal connection, a thermistor signal connection, a photodiode signal connection, a light emitting diode signal connection, and an aiming beam connection.", "18.The system of claim 5, wherein the at least one laser module includes an electronic identifier configured and arranged to be sent to the control module via the detachable cable.", "19.The system of claim 5, and further configured to send a feedback signal via the detachable cable, the feedback signal including the operation condition of the laser module.", "20.The system of claim 1, wherein an assembly of at least the handpiece, the at least one laser module, and the cable connector includes a microprocessor that includes instructions for i) controlling an output parameter of the at least one laser module, and ii) monitoring an operation condition of the at least one laser module." ], [ "<SOH> BACKGROUND <EOH>Electromagnetic energy devices are employed in a variety of applications.", "For example, a simple incandescent light may be used to illuminate an area with electromagnetic energy in a form of visible light.", "Another form of electromagnetic energy, such as a laser beam, may be used to illuminate an area, to identify a target, or to deliver concentrated energy to a target in order to perform various procedures such as melting, cutting, or the like.", "Certain medical devices may deliver electromagnetic energy to a target surface such as, for example, an eye, in order to correct a deficiency in visual acuity.", "Other medical devices may direct electromagnetic energy toward a surface of a tooth to perform, for example, a cutting or whitening operation.", "Endoscopic devices can be used to enhance visualization of internal parts of, for example, a human body in order to detect or remove diseased tissue." ], [ "<SOH> SUMMARY <EOH>A handpiece assembly comprising a detachable cable configured and arranged to receive at least power, a detachable cable connector, where the detachable cable connector and detachable cable are reversibly attachable to each other.", "Some embodiments include at least one interchangeable laser module, where the at least one interchangeable laser module and the detachable cable connector are reversibly attachable to each other.", "Further, in some embodiment, the at least one interchangeable laser module is configured and arranged to receive at least the power via the cable connector when coupled to the cable connector, and to be removed from the detachable cable connector and replaced with another laser module.", "Further, some embodiments include at least one interchangeable handpiece, where at least one interchangeable handpiece and the at least one interchangeable laser module are reversibly attachable to each other.", "Further, in some embodiments, the at least one interchangeable handpiece is configured and arranged to be removed from the at least one interchangeable laser module and replaced with at least one other interchangeable handpiece.", "Some embodiments of the invention further comprise a power supply remote from the at least one interchangeable laser module and coupled to the detachable cable at an end of the cable opposite from the cable connector.", "Some other embodiments include at least one interchangeable laser module that include at least one of a laser diode, a diode-pumped solid state laser, a flashlamp-pumped solid state laser, and a light emitting diode.", "In some embodiments, at least one laser module and the another laser module are configured and arranged to generate electromagnetic energy with wavelengths that differ from each other.", "Some embodiments include a controller, remote from the at least one laser.", "In some embodiments, the controller is configured and arranged to be coupled to the at least one laser module using the at least one detachable cable.", "Some embodiments further comprise a remote controller.", "In some embodiments, the remote controller is operatively coupled to the controller using a wired coupling.", "In some embodiments, the remote controller and controller include wireless circuitry configured to enable wireless communication between the remote controller and the controller.", "Some embodiments further comprise a control module coupled or integrated with the power supply.", "In some embodiments, the control module includes a wireless controller configured and arranged to be wirelessly controlled with a smartphone or a tablet computer.", "In some embodiments, the power supply and control module are coupled with or integrated into a dental chair.", "In some embodiments, the system includes at least one display terminal mounted, coupled, or integrated with the dental chair.", "Some embodiments include at least one display terminal configured to display information based on one or more sensor signal from a coupled assembly of the handpiece, at least one laser module, and detachable cable connector.", "Some embodiments include a user interface configured to control signals to the at least one laser module.", "In some embodiments, the detachable cable includes at least one fluid channel configured and arranged to deliver at least one fluid to the handpiece.", "In some embodiments, the detachable connector comprises connections including a laser power control signal connection, fluid intake and output connections, an identification code signal connection, a thermistor signal connection, a photodiode signal connection, a light emitting diode signal connection, and an aiming beam connection.", "In some embodiments, the at least one laser module includes an electronic identifier configured and arranged to be sent to the control module via the detachable cable.", "In some embodiments, the system is further configured to send a feedback signal via the detachable cable, the feedback signal including the operation condition of the laser module.", "Some embodiments include an assembly of at least the handpiece, at least one laser module and the cable connector includes a microprocessor that includes instructions for i) controlling an output parameter of the at least one laser module, and ii) monitoring an operation condition of the at least one laser module." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation application of U.S. patent application Ser.", "No.", "14/060,877 filed on Oct. 23, 2013, entitled “Handpiece Assembly for Laser Treatment Device”, which claims priority to U.S.", "Provisional Patent Application No.", "61/717,956, filed Oct. 24, 2012, entitled “Laser Module for a Dental Chair Terminal,” and to U.S.", "Provisional Patent Application No.", "61/777,112, filed Mar.", "12, 2013, entitled “Interchangeable Laser Module for a Dental Chair Terminal,” which are herein incorporated by reference in their entireties.", "TECHNICAL FIELD The technology described herein relates generally to a laser treatment device and more particularly to a replaceable handpiece assembly for delivering electromagnetic energy to a target surface.", "BACKGROUND Electromagnetic energy devices are employed in a variety of applications.", "For example, a simple incandescent light may be used to illuminate an area with electromagnetic energy in a form of visible light.", "Another form of electromagnetic energy, such as a laser beam, may be used to illuminate an area, to identify a target, or to deliver concentrated energy to a target in order to perform various procedures such as melting, cutting, or the like.", "Certain medical devices may deliver electromagnetic energy to a target surface such as, for example, an eye, in order to correct a deficiency in visual acuity.", "Other medical devices may direct electromagnetic energy toward a surface of a tooth to perform, for example, a cutting or whitening operation.", "Endoscopic devices can be used to enhance visualization of internal parts of, for example, a human body in order to detect or remove diseased tissue.", "SUMMARY A handpiece assembly comprising a detachable cable configured and arranged to receive at least power, a detachable cable connector, where the detachable cable connector and detachable cable are reversibly attachable to each other.", "Some embodiments include at least one interchangeable laser module, where the at least one interchangeable laser module and the detachable cable connector are reversibly attachable to each other.", "Further, in some embodiment, the at least one interchangeable laser module is configured and arranged to receive at least the power via the cable connector when coupled to the cable connector, and to be removed from the detachable cable connector and replaced with another laser module.", "Further, some embodiments include at least one interchangeable handpiece, where at least one interchangeable handpiece and the at least one interchangeable laser module are reversibly attachable to each other.", "Further, in some embodiments, the at least one interchangeable handpiece is configured and arranged to be removed from the at least one interchangeable laser module and replaced with at least one other interchangeable handpiece.", "Some embodiments of the invention further comprise a power supply remote from the at least one interchangeable laser module and coupled to the detachable cable at an end of the cable opposite from the cable connector.", "Some other embodiments include at least one interchangeable laser module that include at least one of a laser diode, a diode-pumped solid state laser, a flashlamp-pumped solid state laser, and a light emitting diode.", "In some embodiments, at least one laser module and the another laser module are configured and arranged to generate electromagnetic energy with wavelengths that differ from each other.", "Some embodiments include a controller, remote from the at least one laser.", "In some embodiments, the controller is configured and arranged to be coupled to the at least one laser module using the at least one detachable cable.", "Some embodiments further comprise a remote controller.", "In some embodiments, the remote controller is operatively coupled to the controller using a wired coupling.", "In some embodiments, the remote controller and controller include wireless circuitry configured to enable wireless communication between the remote controller and the controller.", "Some embodiments further comprise a control module coupled or integrated with the power supply.", "In some embodiments, the control module includes a wireless controller configured and arranged to be wirelessly controlled with a smartphone or a tablet computer.", "In some embodiments, the power supply and control module are coupled with or integrated into a dental chair.", "In some embodiments, the system includes at least one display terminal mounted, coupled, or integrated with the dental chair.", "Some embodiments include at least one display terminal configured to display information based on one or more sensor signal from a coupled assembly of the handpiece, at least one laser module, and detachable cable connector.", "Some embodiments include a user interface configured to control signals to the at least one laser module.", "In some embodiments, the detachable cable includes at least one fluid channel configured and arranged to deliver at least one fluid to the handpiece.", "In some embodiments, the detachable connector comprises connections including a laser power control signal connection, fluid intake and output connections, an identification code signal connection, a thermistor signal connection, a photodiode signal connection, a light emitting diode signal connection, and an aiming beam connection.", "In some embodiments, the at least one laser module includes an electronic identifier configured and arranged to be sent to the control module via the detachable cable.", "In some embodiments, the system is further configured to send a feedback signal via the detachable cable, the feedback signal including the operation condition of the laser module.", "Some embodiments include an assembly of at least the handpiece, at least one laser module and the cable connector includes a microprocessor that includes instructions for i) controlling an output parameter of the at least one laser module, and ii) monitoring an operation condition of the at least one laser module.", "BRIEF DESCRIPTION OF THE FIGURES FIG.", "1 depicts an example laser system including a power supply and control module included in a dental chair and a handpiece assembly connected to the power supply and control module.", "FIG.", "2A depicts an example handpiece assembly including a cable connector, a laser module, a handpiece, and a tip.", "FIG.", "2B depicts an example handpiece assembly including a cable connector, a laser module, a handpiece, and a tip, showing the constituent pieces connected to each other to form a single unit.", "FIG.", "3 depicts an example laser system including a variety of interchangeable laser modules and a variety of interchangeable handpieces.", "FIG.", "4 depicts an example laser system for use with a dental chair.", "FIG.", "5 depicts example cable connectors that are used in connecting a power supply and control module, a handpiece assembly, and a laser module included in the handpiece assembly.", "FIG.", "6 depicts an example laser system illustrating exemplary connections between an instrument panel of a dental chair, a power supply and control module, and a handpiece assembly.", "DETAILED DESCRIPTION FIG.", "1 depicts an example laser system 100 including a power supply and control module 102 included in a dental chair 120 and a handpiece assembly 104 connected to the power supply and control module 102.In the example laser system 100, the power supply and control module 102 is used to provide power and control signals to the handpiece assembly 104 via a cable 106.For example, the power provided by the power supply and control system 102 may include a DC voltage that is used to provide a driving current to a laser module 110 included in the handpiece assembly 104.The control signals provided by the power supply and control module 102 to the handpiece assembly 104 include various electronic signals for controlling operation of the laser module 110.For example, the control signals may be used to turn the laser module 110 on, shut the laser module 110 off, control a maximum output power that can be provided by the laser module 110, or to control various other aspects of the handpiece assembly 104.The power supply and control module 102 is mounted inside or on an instrument terminal of the dental chair 120.The handpiece assembly 104 includes a cable connector 108, the laser module 110, a handpiece 114, and a tip 115.The cable connector 108 is detachably coupled to the power supply and control module 102 via the cable 106 and is used to receive the power and control signals from the power supply and control module 102.The cable connector 108 thus includes the necessary connections to receive the power and control signals and to thereafter distribute the received power and control signals to other portions of the handpiece assembly 104.It is noted that although the example illustration of FIG.", "1 depicts the cable connector 108 as being separate from the handpiece assembly 104, in other examples, the cable connector 108 is integrated within the handpiece assembly 104 and is considered a part of the handpiece assembly in such other examples.", "The laser module 110 of the handpiece assembly 104 is connected to the cable connector 108 and is configured to receive the power and control signals from the cable connector 108.Based on the received power and control signals, the laser module 110 generates electromagnetic energy 112 (e.g., laser light).", "The laser module 110 may be, for example, a laser diode, a diode-pumped solid state laser, a flashlamp-pumped solid state laser, a light emitting diode, or another type of light-generating component.", "The handpiece 114 receives the electromagnetic energy 112 from the laser module 110 and directs the electromagnetic energy 112 to a target surface 118.In the example of FIG.", "1, the target surface may be an area of a dental patient's mouth (e.g., teeth, gums, etc.).", "The handpiece 114 is application-specific and may thus include a geometry or optics (e.g., lenses, etc.)", "that are specific for a particular clinical application.", "In directing the electromagnetic energy 112 to the target surface 118, the tip 115 is used.", "The tip 115 receives the electromagnetic energy 112 from the handpiece 114 and may include fiber optic materials, sapphire, or other optical materials.", "Further, the tip 115 may be shaped to be optimized for a particular clinical application.", "As described above, the handpiece assembly 104 includes the cable connector 108 that is detachably coupled to the power supply and control module 102 and is used to receive the power and control signals from the power supply and control module 102.The cable connector 108 is designed to match a cable connector 122 included on the dental chair 120, such that various signals and substances are transported between the dental chair 120 and handpiece assembly 104 over the cable 106.As illustrated at 124, the signals and substances transported over the cable 106 include the aforementioned power and control signals and also include pressurized air, water or another liquid, a feedback signal, and a unique identifier.", "The cable 106 includes the connections necessary to allow communication in both directions between the dental chair 120 and the handpiece assembly 104.Thus, communications from the dental chair 120 to the handpiece assembly 104 include the power and control signals that are received at the cable connector 108 and used by the laser module 110 in generating the electromagnetic energy 112.The cable 106 also includes an air channel or a water channel for delivering the pressurized air or water from the dental chair 120 to the handpiece assembly 104.The pressurized air or water is used at the handpiece assembly 104 to cool the laser module 110 or to provide an air or water spray at or around the target surface 118.Communications from the handpiece assembly 104 to the dental chair 120 include the aforementioned feedback signal.", "The feedback signal includes various operation conditions of the laser module 110, which may indicate, for example, an output power of the laser module 110, a temperature of the laser module 110, or a presence of other signals for diagnostic applications.", "In one example, the handpiece assembly 104 includes a microprocessor with instructions for controlling output parameters of the laser module 110 (e.g., controlling an output power of the laser module 110) and for monitoring operation conditions of the laser module 110.The instructions of the microprocessor are received from the power supply and control module 102 via the cable 106.In examples where the microprocessor is included in the handpiece assembly 104, the feedback signal includes various operation conditions of the laser module 110 that are monitored by the microprocessor.", "Communications from the handpiece assembly 104 to the dental chair 120 also include the aforementioned unique identifier.", "In an example, the laser module 110 includes a unique electronic identifier.", "The electronic identifier includes information about the type of laser included in the laser module 110 and calibration parameters of the laser module 110.By transmitting the unique identifier for the laser module 110 to the power supply and control module 102, safeguards are triggered within the power supply and control module 102 to protect the laser module 110.For example, the unique identifier is used to indicate a maximum driving current that may be received by the laser module 110, such that the power supply and control module 102 can constrain the driving current supplied based on this value.", "Further, the unique identifier is used generally for identification of the laser module 110 by the dental chair 120 or the power supply and control module 102.Conventionally, laser systems for dental or medical applications include laser modules positioned in one of two typical configurations.", "In a first typical configuration, the laser module is positioned in a system housing.", "In this configuration, both the power supply and control module and the laser module are included in the system housing, and a delivery system is used for delivering electromagnetic energy from the system housing to a delivery device.", "For example, in the first typical configuration, the electromagnetic energy is generated in the housing, and a fiber cable is used to deliver the generated electromagnetic energy to a handpiece assembly.", "In a second typical configuration, the laser module is included in a handpiece assembly, where the handpiece assembly also includes a power supply and control module.", "Thus, in the second typical configuration, all portions of the laser system (e.g., a battery to be used as a power supply, necessary controls, and the laser module used to generate the electromagnetic energy based on the current supplied by the battery) are integrated within the single handpiece assembly.", "By contrast, the laser system 100 utilizes a hybrid configuration that differs from both of the typical configurations described above.", "In the hybrid configuration, the power supply and control module 102 is physically separated from the laser module 110.As described above, the handpiece assembly 104 including the laser module 110 is separate and distinct from the power supply and control module 102, such that the power supply and control module 102 is not integrated within the handpiece assembly 104.Thus, in the laser system 100, the power supply and control module 102 is separated from both of the handpiece assembly 104 and laser module 110.Further, in the example laser system 100 of FIG.", "1, the cable 106 does not include a fiber cable, such that the laser system 100 differs from embodiments of the first typical configuration that use a fiber cable as a delivery system.", "In an example of the laser system 100, no fiber cables are used in any portion of the system 100.In the hybrid configuration of the laser system 100, the handpiece assembly 104 (including the cable connector 108, the laser module 110, and the handpiece 114) is a replaceable, interchangeable module.", "The replaceable, interchangeable nature of the handpiece assembly 104 allows a particular handpiece assembly to be disconnected from the system 100 and replaced with another handpiece assembly without requiring replacement of the power supply and control module 102.The replaceable, interchangeable nature of the handpiece assembly 104 is facilitated by the cable connector 108 of the handpiece assembly 104, which allows the handpiece assembly 104 to be detachably coupled to the power supply and control module 102.The detachable coupling allows the handpiece assembly 104 to be disconnected easily from the power supply and control module 102.Specifically, in an example, the handpiece assembly 104 is disconnected from the power supply and control module 102 by disconnecting the cable 106 from the power supply and control module 102.To further facilitate the replaceable, interchangeable nature of the handpiece assembly 104, the laser system 100 of FIG.", "1 utilizes standardized connectors for the connectors 108, 122.In this manner, any handpiece assembly 104 including the proper standardized connector can be swapped into and out of the laser system 100, thus allowing handpiece assemblies with different parameters (e.g., handpiece assemblys configured to generate electromagnetic energy 112 of different wavelengths) to be easily connected and disconnected from the system 100.The standardized connectors between the handpiece assembly 104 and the dental chair 120 also prevent operation of unknown or unauthorized devices within the system 100.For example, the standardized connectors may have a unique design to ensure that unauthorized or noncompliant instruments or laser modules cannot be connected to the system 100.FIGS.", "2A and 2B depict an example handpiece assembly including a cable connector 202, a laser module 206, a handpiece 208, and a tip 209.In FIG.", "2A, the constituent pieces 202, 206, 208, 209 of the handpiece assembly are disassembled, and in FIG.", "2B, the constituent pieces 202, 206, 208, 209 are connected to each other to form a single handpiece assembly unit.", "The cable connector 202 is detachably connected to a power supply and control module via a cable 204 (e.g., as illustrated in the example laser system 100 of FIG.", "1).", "The cable connector 202 is used to receive power and control signals from the power supply and control module.", "The laser module 206 is connected to the cable connector 202 and is used to receive the power and control signals from the cable connector 202.Based on the power and control signals, the laser module 206 generates electromagnetic energy.", "The handpiece 208 is connected to the laser module 206 and receives the electromagnetic energy from the laser module 206.The handpiece 208 is used to direct the electromagnetic energy to a target surface (e.g., a tissue surface or other part of a human body).", "In directing the electromagnetic energy to the target surface, the electromagnetic energy is passed through the tip 209, which may have a geometry that is optimized for a particular clinical application.", "In FIGS.", "2A and 2B, the cable 204 includes air and water channels and electrical connections for delivering pressurized air, water, and the power and control signals.", "The laser module 206 may include a laser diode, a diode-pumped solid state laser, a flashlamp-pumped solid state laser, or a light emitting diode.", "The laser module 206 generates electromagnetic energy at a wavelength in the range of approximately 400 nm to 3.0 lam and with an average power in a range of approximately 0.1 W to 20 W. The laser module 206 operates in a continuous-wave (CW) mode or a pulsed operation mode.", "In one example, the handpiece 208 is a rotatable handpiece that is designed for a specific application.", "The handpiece 208 may include optical elements (e.g., a lens, mirror, filter, beamsplitter, prism, grating, etc.)", "or the handpiece may have no permanent optics.", "The handpiece 208 may be autoclavable, or the handpiece 208 may be disinfected with a disinfecting solution or used with a sterile sleeve or cover.", "FIG.", "3 depicts an example laser system 300 including a variety of interchangeable laser modules 306A, 306B, 306C and a variety of interchangeable handpieces 308A, 308B, 308C.", "In the example laser system 300, a power supply and control module 310 is used to provide power and control signals to a handpiece assembly 305 via a cable 304.The handpiece assembly 305 includes a cable connector 302, a laser module 306, a handpiece 308, and a tip 309.The cable connector 302 is detachably coupled to the power supply and control module 310 via the cable 304 and is used to receive the power and control signals from the power supply and control module 310.The cable connector 302 matches a cable connector 312 of the power supply and control module 310.The laser module 306 of the handpiece assembly 305 receives the power and control signals from the cable connector 302 and generates electromagnetic energy, and the handpiece 308 receives the electromagnetic energy from the laser module 306.Because the power supply and control module 310 may be included within a dental chair, the laser system 300 further includes an optional footswitch 318.The footswitch 318 is used, for example, to actuate the laser output of the laser module 306.The handpiece assembly 305 is a replaceable, interchangeable module.", "The replaceable, interchangeable nature of the handpiece assembly 305 allows a particular handpiece assembly to be disconnected from the system 300 and replaced with another handpiece assembly without requiring replacement of the power supply and control module 310.In a similar manner, both the laser module 306 and the handpiece 308 are also replaceable and interchangeable.", "The laser module 306 is detachably coupled to the cable connector 302 and to the handpiece 308.The detachable coupling between the laser module 306 and the cable connector 302 and the handpiece 308 allows the laser module 306 to be easily removed from the handpiece assembly 305.Further, due to the replaceable nature of the laser module 306, a particular laser module can be removed from the handpiece assembly 305 and replaced with another laser module without requiring replacement of any other components of the system 300 (e.g., without requiring replacement of the cable connector 302, the handpiece 308, or the power supply and control module 310).", "The replaceable nature of the laser module 306 is highlighted in FIG.", "3, which illustrates the variety of interchangeable laser modules 306A, 306B, 306C.", "The different laser modules 306A, 306B, 306C in the example of FIG.", "3 each generate electromagnetic energy at a different wavelength.", "For example, the laser module 306A generates electromagnetic energy at a wavelength of 940 nm, the laser module 306B generates electromagnetic energy at a wavelength of 810 nm, and the laser module 306C generates electromagnetic energy at a wavelength of 660 nm.", "In a similar manner, the laser module 306 may be configured to work with different, interchangeable laser modules that utilize different laser types.", "For example, the interchangeable laser modules may include a laser module that utilizes a laser diode, a laser module that utilizes a diode-pumped solid state laser, a laser module that utilizes a flashlamp-pumped solid state laser, or a laser module that utilizes a light emitting diode.", "As noted above, the handpiece 308 is also a replaceable and interchangeable module.", "The handpiece 308 is detachably coupled to the laser module 306.The detachable coupling between the handpiece 308 and the laser module 306 allows the handpiece 308 to be easily removed from the handpiece assembly 305.Further, due to the replaceable nature of the handpiece 308, a particular handpiece can be removed from the handpiece assembly 305 and replaced with another handpiece without requiring replacement of any other components of the system 300 (e.g., without requiring replacement of the cable connector 302, the laser module 306, or the power supply and control module 310).", "The replaceable nature of the handpiece 308 is highlighted in FIG.", "3, which illustrates the variety of interchangeable handpieces 308A, 308B, 308C.", "The different handpieces 308A, 308B, 308C in the example of FIG.", "3 are each adapted for different clinical operations.", "For example, the handpiece 308A is adapted for performing surgery, the handpiece 308B is adapted for whitening teeth, and the handpiece 308C is adapted for a pain therapy clinical operation.", "The interchangeable handpieces 308A, 308B, 308C may also have different geometries, different optics, and other varying properties.", "As illustrated in FIG.", "3, certain of the interchangeable laser modules 306A, 306B, 306C are usable with only certain of the interchangeable handpieces 308A, 308B, 308C, and vice versa.", "For example, although the laser module 306A is usable with each of the three handpieces 308A, 308B, 308C, the laser module 306C is usable with only the handpiece 308C.", "In other examples, however, all laser modules 306A, 306B, 306C are usable with all handpieces 308A, 308B, 308C, and vice versa.", "In the example of FIG.", "3, the surgical handpiece 308A uses the replaceable tip 309.The whitening handpiece 308B and the pain control handpiece 308C do not use a tip but may use disposable protective covers.", "The replaceable and interchangeable handpiece assembly 305, laser module 306, and handpiece 308 facilitate economical upgrading of the laser system 300.For example, a new laser module can replace a failing, old laser module, and this replacement does not require replacement of other components of the system 300.FIG.", "4 depicts an example laser system 400 for use with a dental chair 401.In the example laser system 400, a power supply and control module is integrated within a portion of the dental chair 401.A handpiece assembly 406 includes a cable connector 410, interchangeable laser modules 412, 414, 416, 418, and interchangeable handpieces 420, 422, 424, 426.The cable connector 410 is detachably coupled to the power supply and control module via the cable 408 and is used to receive power and control signals from the power supply and control module.", "The cable 408 includes an air channel or a water channel for delivering pressurized air or water from the dental chair 401 to the handpiece assembly 406.As illustrated in FIG.", "4, the dental chair 401 includes a footswitch 403, which is used to actuate the laser output of the handpiece assembly 406.The dental chair 401 further includes instrument terminals 402, 404.The instrument terminals 402, 404 are used to hold the handpiece assembly 406 when the handpiece assembly 406 is not in use.", "A sensor signal from one or both of the instrument terminals 402, 404 indicates whether the handpiece assembly 406 is within a holder included on the instrument terminal 402 or 404.The sensor signal is used in one example to automatically switch the laser system 400 between “standby” and “ready” modes, and a signal from the footswitch 403 may be used to actuate the laser output of the handpiece assembly 406 when the laser system 400 is in the “ready” mode.", "The dental chair 401 further includes a user interface that is configured to read a signal from the power supply and control module.", "The user interface is used to generate a display that indicates when the handpiece assembly 406 has been removed from the instrument terminals 402, 404.The dental chair 401 includes wireless communication circuitry 430.For example, the power supply and control module includes the wireless communication circuitry 430, and the wireless communication circuitry 430 is used to receive a signal from a wireless remote control 428 or to communicate with a network.", "The wireless remote control 428 is used to actuate the laser output of the handpiece assembly 406, send various control signals from the power supply and control module to the handpiece assembly 406, or otherwise control one or more operations of the handpiece assembly 406.The wireless remote control 428 is, in an example, a smartphone or a tablet computer (e.g., running the Android operating system or the Apple iOS operating system) that is able to communicate in a wireless manner with the wireless communication circuitry 430.Although the wireless connection capabilities of the remote control 428 are described above, in other examples, the remote control 428 is a wired controller, such that the remote control 428 communicates with the dental chair 401 or the handpiece assembly 406 via a wired connection.", "The handpiece assembly 406 is a replaceable, interchangeable module.", "Similarly, the laser module and the handpiece included within the handpiece assembly 406 are also replaceable and interchangeable, such that both the laser module and the handpiece can be easily removed from the handpiece assembly 406 and replaced with another compatible laser module and handpiece, respectively.", "The replaceable nature of the laser module is highlighted in FIG.", "4, which illustrates the variety of interchangeable laser modules 412, 414, 416, 418.The different laser modules 412, 414, 416, 418 each generate electromagnetic energy at a different wavelength and are adapted for different clinical operations.", "For example, the laser module 412 generates blue laser light that is useful for cancer detection and curing of dental composite materials; the laser module 414 generates red laser light that is useful for photoradiation therapy or photodynamic therapy (PDT); the laser module 416 generates laser light at 940 nm that is useful for pain therapy, teeth whitening, and surgery applications; and the laser module 418 generates laser light at 810 nm that is useful for biostimulation applications.", "The handpiece is also a replaceable and interchangeable module.", "The replaceable nature of the handpiece is highlighted in FIG.", "4, which illustrates the variety of interchangeable handpieces 420, 422, 424, and 426.The different handpieces 420, 422, 424, 426 are application specific, such that they are adapted for different clinical operations.", "For example, the handpiece 420 is used with the laser module 412 for cancer detection and curing of dental composite materials; the handpiece 422 is used with the laser module 414 for performing photoradiation therapy or photodynamic therapy (PDT); the handpiece 424 is used with the laser module 416 or the laser module 418 and is adapted for performing clinical operations at the wavelength ranges of the modules 416, 418; and the handpiece 426 is used with the laser module 416 or the laser module 418 and is adapted for performing clinical operations at the wavelength ranges of the modules 416, 418.FIG.", "5 depicts example cable connectors 502, 504, 508 that are used in connecting a power supply and control module, a handpiece assembly, and a laser module included in the handpiece assembly.", "The handpiece assembly includes the cable connector 504, and the cable connector 504 is detachably coupled to the cable connector 502 of the power supply and control module via a cable 506.The cable connector 504 is used to receive power and control signals from the power supply and control module.", "The cable connector 504 thus includes the necessary connections to receive the power and control signals and to thereafter distribute the received power and control signals to other portions of the handpiece assembly.", "The cable connector 504 of the handpiece assembly is designed to match the cable connector 502 of the power supply and control module.", "With the matching connectors 502, 504, various signals and substances are transported between the power supply and control module (or a dental chair that houses the power supply and control module) and the handpiece assembly.", "The connectors 502, 504 are standardized connectors, and any handpiece assembly including the proper standardized connector can be swapped into and out of the system.", "This allows handpiece assemblies with different parameters to be easily connected and disconnected from the system.", "The standardized connectors 502, 504 also prevent operation of unknown or unauthorized devices within the system.", "As illustrated in FIG.", "5, the standardized connectors 502, 504 include connections or channels for transferring a laser power control signal (“Power”), air intake and output (“Air IN” and “Air OUT”), an identification code signal (“ID”), a signal from a thermistor (“Thermistor”), a signal from a photodiode (“Photodiode”), a signal from a light emitting diode (“LED”), and an aiming beam (“Aiming”).", "The signal from the thermistor is provided from a thermistor included within or near the laser module.", "The signal from the thermistor is an example of a feedback signal that is transmitted from the handpiece assembly to the power supply and control module.", "The signal from the photodiode is provided from a photodiode included within or near the laser module.", "The signal from the photodiode is another feedback signal used to indicate an output power of the laser module.", "Similarly, the identification code signal is a feedback signal sent from the laser module to the power supply and control module and is used to identify the laser module included in the handpiece assembly.", "In contrast to the aforementioned feedback signals, the aiming beam is transmitted from the power supply and control module to the handpiece assembly.", "The aiming beam is a visible light beam that may be used in aiming the output of the laser module.", "The signal from the light emitting diode is also transmitted from the power supply and control module to the handpiece assembly and may be used to indicate that the system is in a “ready” mode (e.g., the signal may turn on LEDs at the handpiece assembly and the power supply and control module to indicate the “ready” mode).", "The cable 506 includes integrated electrical and air lines to ensure flexibility of a user's movements (e.g., to ensure flexibility of a dentist's movements within an operating area).", "The cable connector 504 of the handpiece assembly also matches the connector 508 of the laser module, such that the aforementioned signals and substances (e.g., the signal from the thermistor, the signal from the photodiode, the aiming beam, the identification code signal, the laser power control signal, and the air intake and output) can be transferred between the laser module and the cable connector 504 of the handpiece assembly.", "FIG.", "6 depicts an example laser system 600 illustrating exemplary connections between an instrument panel 604 of a dental chair 602, a power supply and control module 608, and a handpiece assembly 615.In FIG.", "6, cable connectors 614, 616, 620 of the power supply and control module 608, the handpiece assembly 615, and the laser module, respectively, are similar to those described above with reference to FIG.", "5.The cable connector 616 of the handpiece assembly 615 is designed to match the cable connector 614 of the power supply and control module 608.With the matching connectors 614, 616, various signals and substances are transported between the power supply and control module 608 and the handpiece assembly 615.Specifically, the connectors 614, 616 include connections or channels for transferring a laser power control signal, air intake and output, an identification code signal, a signal from a thermistor, a signal from a photodiode, a signal from a light emitting diode, and an aiming beam.", "These signals and substances are transferred over the cable 618.The cable connector 616 of the handpiece assembly 615 also matches the connector 620 of the laser module.", "As illustrated in FIG.", "6, the instrument panel 604 of the dental chair 602 is used to provide the air intake and output to the cable connector 614.The power supply and control module 608 includes connections for connecting to the cable connector 614 and is thus configured to transmit the laser power control signal, the signal from the light emitting diode, and the aiming beam and to receive the identification code signal, the signal from the thermistor, and the signal from the photodiode.", "The power supply and control module 608 is also connected to the instrument panel 604, a footswitch 606, and a remote control 612.The instrument panel 604 of the dental chair 602 provides a DC supply voltage and a sensor output to the power supply and control module 608.The DC supply voltage is used by the power supply and control module 608 to provide a driving current to the laser module included in the handpiece assembly 615.The sensor output indicates whether the handpiece assembly 615 is within a holder included on the dental chair 602, and the sensor output is used in one example to automatically switch the laser system 600 between “standby” and “ready” modes.", "The footswitch 606 provides a signal to the power supply and control module 608, where the signal is used to actuate the laser output of the handpiece assembly 615 when the laser system 600 is in the “ready” mode.", "The remote control 612 also provides a signal to the power supply and control module 608.Although the remote control 612 is depicted as being connected to the power supply and control module 608 via a wired connection, the remote control 612 may also be connected to the power supply and control module 608 via a wireless connection.", "For example, the power supply and control module 608 includes an antenna 610 for facilitating wireless communications with the remote control 612.The remote control 612 is used to actuate the laser output of the handpiece assembly 615, cause various control signals to be sent from the power supply and control module 608 to the handpiece assembly 615, or otherwise control one or more operations of the handpiece assembly 615.While the disclosure has been described in detail and with reference to specific embodiments thereof, it will be apparent to one skilled in the art that various changes and modifications can be made therein without departing from the spirit and scope of the embodiments.", "Thus, it is intended that the present disclosure cover the modifications and variations of this disclosure provided they come within the scope of the appended claims and their equivalents.", "For example, although the present disclosure is described in terms of a dental or medical device, it will be apparent to one skilled in the art that the systems described herein have applications outside of dental and medical applications.", "It should be understood that as used in the description herein and throughout the claims that follow, the meaning of “a,” “an,” and “the” includes plural reference unless the context clearly dictates otherwise.", "Also, as used in the description herein and throughout the claims that follow, the meaning of “in” includes “in” and “on” unless the context clearly dictates otherwise.", "Further, as used in the description herein and throughout the claims that follow, the meaning of “each” does not require “each and every” unless the context clearly dictates otherwise.", "Finally, as used in the description herein and throughout the claims that follow, the meanings of “and” and “or” include both the conjunctive and disjunctive and may be used interchangeably unless the context expressly dictates otherwise; the phrase “exclusive of may be used to indicate situations where only the disjunctive meaning may apply." ] ]
Patent_15872859
[ [ "DESCRIPTION OF IMAGE COMPOSITION WITH HEVC STILL IMAGE FILE FORMAT", "A method of encapsulating an encoded bitstream representing one or more images includes providing description of images and/or sub-image picture, providing composed picture description, and outputting the bitstream.", "The description of images and/or sub-image pictures identifying portions of the bitstream representing the images and/or sub-images of the one or more images is provided.", "The composed picture description of at least one composed picture formed by one or more images and/or sub-image pictures also is provided.", "The bitstream, together with the composed picture description, is output as an encapsulated data file." ], [ "1.A method for generating an image file based on a plurality of images, the method comprising: obtaining the plurality of images; and generating the image file based on the plurality of images, wherein the image file includes offset information for identifying a data position of each of the plurality of images within the image file, and includes composition image information relating to a composition image that is based on the plurality of images.", "2.The method according to claim 1, wherein the composition image information includes information representing a width and a height of the composition image.", "3.The method according to claim 1, wherein the composition image information includes information representing a spatial offset of each of the plurality of images within the composition image.", "4.The method according to claim 3, wherein the spatial offset represents a horizontal offset and a vertical offset of each of the plurality of images within the composition image.", "5.The method according to claim 1, wherein the composition image information includes an identifier of each of the plurality of images, and wherein each identifier is associated with its horizontal and vertical offset within the composition image.", "6.The method according to claim 1, wherein the composition image information includes number information representing a number of images in the plurality of images to be used for generating the composition image.", "7.The method according to claim 1, wherein the composition image information includes number information representing a number of images in a row direction and a number of images in a column direction within the composition image.", "8.The method according to claim 6, wherein the composition image information includes an item reference for linking the composition image with the number of images.", "9.The method according to claim 1, wherein the composition image information further includes layering information to layer the plurality of images to obtain the composition image.", "10.The method according to claim 1, wherein at least part of the plurality of images share the same decoder configuration.", "11.The method according to claim 1, wherein the composition image is identified by a specific type.", "12.The method according to claim 1, wherein the composition image is signaled as a default image to be displayed by a client.", "13.A device for generating an image file based on a plurality of images, the device comprising: an obtaining unit configured to obtain the plurality of images; and a generating unit configured to generate the image file based on the plurality of images, wherein the image file includes offset information for identifying a data position of each of the plurality of images within the image file, and includes composition image information relating to a composition image that is based on the plurality of images.", "14.The device according to claim 13, wherein the composition image information includes information representing a width and a height of the composition image, and the generating unit is further configured to generate the composition image having the width and the height represented by the composition image information.", "15.The device according to claim 13, wherein the composition image information includes information representing a spatial offset of each of the plurality of images within the composition image, and the generating unit is further configured to generate the composition image by composing the one or more images based on the spatial offset represented by the composition image information.", "16.The device according to claim 13, wherein the composition image information includes number information representing a number of images in the plurality of images to be used for generating the composition image, and the generating unit is further configured to generate the composition image by composing the one or more images whose number is represented by the composition image information.", "17.A method for displaying an image according to an image file, the method comprising: obtaining the image file based on a plurality of images, wherein the image file includes offset information for identifying a data position of each of the plurality of images within the image file, and includes composition image information relating to a composition image that is based on the plurality of images; and displaying the composition image by using both of the offset information and the composition image information.", "18.The method according to claim 17, further comprising: identifying, from the image file, the plurality of images to be used for generating the composition image; and generating the composition image based on the images identified and the composition image information.", "19.The method according to claim 18, wherein the composition image information includes information representing a width and a height of the composition image, and wherein generating includes generating the composition image having the width and the height that are represented by the composition image information.", "20.The method according to claim 18, wherein the composition image information includes information representing a spatial offset of each of the plurality of images, and wherein generating includes generating the composition image by composing the plurality of images according to the spatial offset.", "21.The method according to claim 18, wherein the composition image information includes number information representing a number of images in a row direction and a number of images in a column direction within the composition image, and wherein generating includes generating the composition image by composing the plurality of images according to the number of images in a row direction and the number of images in a column direction.", "22.The method according to claim 18, wherein the composition image information includes an item reference for linking the composition image with the number of images, and wherein generating includes generating the composition image by composing the plurality of images according to the item reference.", "23.The method according to claim 18, wherein the composition image information includes layering information to layer the plurality of images to obtain the composition image, and wherein generating includes generating the composition image by composing the plurality of images according to the layering information.", "24.The method according to claim 18, wherein at least part of the plurality of images share the same decoder configuration.", "25.The method according to claim 18, wherein the composition image is identified by a specific type.", "26.The method according to claim 18, wherein the composition image is signaled as a default image to be displayed by a client.", "27.A device for displaying an image according to an image file, the device comprising: an obtaining unit configured to obtain the image file based on one or more images, wherein the image file includes offset information for identifying a data position of each of the one or more images within the image file, and includes composition image information relating to a composition image that is based on the one or more images; and a display control unit configured to cause a display device to display the composition image by using both the offset information and the composition image information.", "28.The device according to claim 27, further comprising: an identifying unit configured to identify, from the image file, the one or more images to be used for generating the composition image; and a generating unit configured to generate the composition image based on the images identified and the composition image information.", "29.The device according to claim 28, wherein the composition image information includes information representing a width and a height of the composition image, and wherein the generating unit is further configured to generate the composition image having the width and the height that are represented by the composition image information.", "30.The device according to claim 28, wherein the composition image information includes information representing a spatial offset of each of the one or more images, and wherein the generating unit is further configured to generate the composition image by composing the one or more images according to the spatial offset." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>According to an aspect of the present invention, a method of encapsulating an encoded bitstream representing one or more images includes providing description of images and/or sub-image pictures identifying portions of the bitstream representing the images and/or sub-images of the one or more images, providing composed picture description of at least one composed picture formed by one or more images and/or sub-image pictures, and outputting the bitstream together with the composed picture description as an encapsulated data file.", "Other features and advantages of the invention will become apparent from the following description of non-limiting exemplary embodiments, with reference to the appended drawings." ], [ "REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "14/881,063, filed on Oct. 12, 2015, which claims the benefit under 35 U.S.C.", "§ 119(a)-(d) of United Kingdom Application No.", "1418203.4, filed on Oct. 14, 2014 and entitled “Description of image composition with HEVC Still Image File Format”, all of which are hereby incorporated by reference herein in their entirety.", "BACKGROUND OF THE INVENTION Field of the Invention The present invention relates to the storage of image data, such as still images, bursts of still images, compositions or cropping of images or video data in a media container with descriptive metadata.", "Such metadata generally provides easy access to the image data and portions of the image data.", "Description of the Related Art Some of the approaches described in this section could be pursued, but are not necessarily approaches that have been previously conceived or pursued.", "Therefore, the approaches described in this section are not necessarily prior art to the claims in this application and are not admitted to be prior art by inclusion in this section.", "The HEVC standard defines a profile for the encoding of still images and describes specific tools for compressing single still images or bursts of still images.", "An extension of the ISO Base Media File Format (ISOBMFF) used for such kind of image data has been proposed for inclusion into the ISO/IEC 23009 standard, in Part 12, under the name: “Image File Format”.", "The standard covers two forms of storage corresponding to different use cases: the storage of image sequences, with timing that is optionally used at the decoder, and in which the images may be dependent on other images, and the storage of single images, and collections of independently coded images.", "In the first case, the encapsulation is close to the encapsulation of the video tracks in the ISO Base Media File Format (see document « Information technology—Coding of audio-visual objects—Part 12: ISO base media file format», ISO/IEC 14496-12:2012, Fourth edition, September 2012), and the same tools and concepts are used, such as the ‘trak’ boxes and the sample grouping for description.", "The ‘trak’ box is a file format box that contains sub boxes for describing a track, that is to say, a timed sequence of related samples.", "In the second case, a set of ISOBMFF boxes, the ‘meta’ boxes are used.", "These boxes and their hierarchy offer less description tools than the ‘track’ boxes and relate to “information items” or “items” instead of related samples.", "The image file format can be used for locally displaying multimedia files or for streaming multimedia presentations.", "HEVC Still Images have many applications which raise many issues.", "Image bursts are one application.", "Image bursts are sequences of still pictures captured by a camera and stored as a single representation (many picture items referencing a block of data).", "Users may want to perform several types of actions on these pictures: select one as thumbnail or cover, apply effects on these pictures or the like.", "There is thus a need for descriptive metadata for identifying the list of pictures with their corresponding bytes in the block of data.", "Computational photography is another application.", "In computational photography, users have access to different resolutions of the same picture (different exposures, different focuses etc.).", "These different resolutions have to be stored as metadata so that one can be selected and the corresponding piece of data can be located and extracted for processing (rendering, editing, transmitting or the like).", "With the increase of picture resolution in terms of size, there is thus a need for providing enough description so that only some spatial parts of these large pictures can be easily identified and extracted.", "Various arrangements of image spatial parts can then produce new images through composition and/or cropping.", "Another kind of applications is the access to specific pictures from a video sequence, for instance for video summarization, proof images in video surveillance data or the like.", "For such kind of applications, there is a need for image metadata enabling to easily access the key images, in addition to the compressed video data and the video tracks metadata.", "In addition, professional cameras have reached high spatial resolutions.", "Videos or images with 4K2K resolution are now common.", "Even 8k4k videos or images are now being common.", "In parallel, video are more and more played on mobile and connected devices with video streaming capabilities.", "Thus, splitting the videos into tiles becomes important if the user of a mobile device wants to display or wants to focus on sub-parts of the video by keeping or even improving the quality.", "By using tiles, the user can therefore interactively request spatial sub-parts of the video.", "There is thus a need for describing these spatial sub-parts of the video in a compact fashion in the file format in order to be accessible without additional processing other than simply parsing metadata boxes.", "For images corresponding to the so-described videos it is also of interest for the user to access to spatial sub-parts.", "As well, for images resulting from cropping and/or composition of these spatial sub-parts, it is also of interest for the user to access these pictures.", "The ISO/IEC 23008 standard covers in its part 12 two ways for encapsulating still images into the file format that have been recently discussed.", "One way is based on ‘track’ boxes, and the notion of timed sequence of related samples with associated description tools, and another is based on ‘meta’ boxes, based on information items, instead of samples, providing less description tools, especially for region of interest description and tiling support.", "There is thus a need for providing tiling support in the new Image File Format.", "The use of tiles is commonly known in the prior art, especially at compression time.", "Concerning their indexation in the ISO Base Media File format, tiling descriptors exist in drafts for amendment of Part 15 of the ISO/IEC 14496 standard “Carriage of NAL unit structured video in the ISO Base Media File Format”.", "However, these descriptors rely on ‘track’ boxes and sample grouping tools and cannot be used in the Still Image File Format when using the ‘meta’ based approach.", "Without such descriptors, it becomes complicated to select and extract tiles from a coded picture stored in this file format.", "FIG.", "1 illustrates the description of a still image encoded with tiles in the ‘meta’ box (100) of ISO Base Media File Format, as disclosed in MPEG contribution m32254.An information item is defined for the full picture 101 in addition to respective information items for each tile picture (102, 103, 104 and 105).", "The box (106), called ‘ItemReferenceBox’, from the ISO BMFF standard is used for indicating that a ‘tile’ relationship (107) exists between the information item of the full picture and the four information items corresponding to the tile pictures (108).", "Identifiers of each information item are used so that a box (109), called ‘ItemLocationBox’, provides the byte range(s) in the encoded data (110) that represent each information item.", "Another box “ItemReferenceBox’” (112) is used for associating EXIF metadata (111) with the information item for the full picture (101) and a corresponding data block (111) is created in the media data box (110).", "Also, an additional information item (113) is created for identifying the EXIF metadata.", "Even if the full picture and its tiles are introduced as information items, no tiling information is provided here.", "Moreover, when associating additional metadata with an information item (like EXIF), no data block referenced using an additional ItemReferenceBox’ is created.", "Reusing information on tiling from EXIF and reusing the mechanism defined in the Still Image File format draft wouldn't make it possible to describe non-regular grid with existing EXIF tags.", "Thus, there is still a need for improvements in the file format for still images, notably HEVC still images.", "In particular, there is a need for methods for extracting a region of interest in still Images stored with this file format.", "The invention lies within the above context.", "SUMMARY OF THE INVENTION According to an aspect of the present invention, a method of encapsulating an encoded bitstream representing one or more images includes providing description of images and/or sub-image pictures identifying portions of the bitstream representing the images and/or sub-images of the one or more images, providing composed picture description of at least one composed picture formed by one or more images and/or sub-image pictures, and outputting the bitstream together with the composed picture description as an encapsulated data file.", "Other features and advantages of the invention will become apparent from the following description of non-limiting exemplary embodiments, with reference to the appended drawings.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 illustrates the description of a still image encoded with tiles in the ‘meta’ box (100) of ISO Base Media File Format, as disclosed in MPEG contribution m32254; FIG.", "2 illustrates an example of a tiled video; FIG.", "3 illustrates various tile/slice configurations in HEVC; FIG.", "4 illustrates the tile encapsulation according to the ISO Base Media File format with ‘track’ boxes; FIG.", "5 illustrates the standard metadata for describing information items in ‘meta’ boxes of the ISOBMFF; FIG.", "6 illustrates an exemplary extension to the information item description; FIG.", "7 illustrates the referencing mechanisms between information items; FIG.", "8 illustrates a context of implementation of embodiments of the invention; FIG.", "9 illustrates an embodiment regarding a method of encapsulation, at server side; FIG.", "10 illustrates an embodiment regarding a parsing method at client side; and FIG.", "11 is a schematic block diagram of a computing device for implementation of one or more embodiments of the invention.", "DETAILED DESCRIPTION OF THE INVENTION In what follows, embodiments of the invention are described.", "In order to better understand the technical context, video tiling is explained with reference to FIG.", "2 which shows a video (200) having consecutive temporal frames.", "Each frame (201) is divided into 8 portions (here rectangular portions) referred to as “tiles” T1 to T8.The number and the shape of the tiles can be different.", "In what follows, it is considered that the tiling is the same whatever the index of the video frame.", "The result of this tiling is 8 independent sub-videos (202).", "These sub-videos represent a partition of the whole global video.", "Each independent sub-video can be encoded as an independent bitstream, according to the AVC or HEVC standards for example.", "The sub-video can also be part of one single video bitstream, like for example tiles of the HEVC standard or slices of the AVC standard.", "The HEVC standard defines different spatial subdivision of pictures: tiles, slices and slice segments.", "These different subdivisions (or partitions) have been introduced for different purposes: the slices are related to streaming issues while the tiles and the slice segments have been defined for parallel processing.", "A tile defines a rectangular region of a picture that contains an integer number of Coding Tree Units (CTU).", "FIG.", "3 shows the tiling of an image (300) defined by row and column boundaries (301, 302).", "This makes the tiles good candidates for regions of interest description in terms of position and size.", "However, the HEVC standard bitstream organization in terms of syntax and its encapsulation into Network Abstract Layer (NAL) units is rather based on slices (as in AVC standard).", "According to the HEVC standard, a slice is a set of slice segments, with at least the first slice segment being an independent slice segment, the others, if any, being dependent slice segments.", "A slice segment contains an integer number of consecutive CTUs (in the raster scan order).", "It has not necessarily a rectangular shape (thus less appropriate than tiles for region of interest representation).", "A slice segment is encoded in the HEVC bitstream as a header called “slice_segment_header” followed by data called “slice_segment_data”.", "Independent slice segments and dependent slice segments differ by their header: dependent slice segments have a shorter header because they reuse information from the independent slice segment's header.", "Both independent and dependent slice segments contain a list of entry points in the bitstream: either to tiles or to entropy decoding synchronization points.", "FIG.", "3 shows different configurations of images 310 and 320 of slice, slice segments and tiles.", "These configurations differ from the configuration of image 300 in which one tile has one slice (containing only one independent slice segment).", "Image 310 is partitioned into two vertical tiles (311, 312) and one slice (with 5 slice segments).", "Image 320 is split into two tiles (321, 322), the left tile 321 having two slices (each with two slice segments), the right tile 322 having one slice (with two slice segments).", "The HEVC standard defines organization rules between tiles and slice segments that can be summarized as follows (one or both conditions have to be met): All CTUs in a slice segment belong to the same tile, and All CTUs in a tile belong to the same slice segment In order to have matching region of interest support and transport, the configuration 300, wherein one tile contains one slice with one independent segment, is preferred.", "However, the encapsulation solution would work with the other configurations 310 or 320.While the tile is the appropriate support for regions of interest, the slice segment is the entity that will be actually put into NAL units for transport on the network and aggregated to form an access unit (coded picture or sample at file format level).", "According to the HEVC standard, the type of NAL unit is specified in a NAL unit header.", "For NAL units of type “coded slice segment”, the slice_segment_header indicates via the “slice_segment_address” syntax element the address of the first coding tree block in the slice segment.", "The tiling information is provided in a PPS (Picture Parameter Set) NAL unit.", "The relation between a slice segment and a tile can then be deduced from these parameters.", "By definition, on tiles borders, the spatial predictions are reset.", "However, nothing prevents a tile from using temporal predictors from a different tile in the reference frame(s).", "In order to build independent tiles, at encoding time, the motion vectors for the prediction units inside a tile are constrained to remain in the co-located tile in the reference frame(s).", "In addition, the in-loop filters (deblocking and SAO) have to be deactivated on the tiles borders so that no error drift is introduced when decoding only one tile.", "This control of the in-loop filters is already available in the HEVC standard and is set in slice segment headers with the flag called “loop_filter_across_tiles_enabled_flag”.", "By explicitly setting this flag to 0, the pixels at the tiles borders do not depend on the pixels that fall on the border of the neighbor tiles.", "When the two conditions on motion vectors and on in-loop filters are met, the tiles are said “independently decodable” or “independent”.", "When a video sequence is encoded as a set of independent tiles, it may be decoded using a tile-based decoding from one frame to another without risking missing reference data or propagation of reconstruction errors.", "This configuration makes it possible to reconstruct only a spatial part of the original video that corresponds, for example, to a region of interest.", "In what follows, independent tiles are considered.", "With reference to FIG.", "4, encapsulation of tiles into ISOBMFF file format is described.", "For example, each tile is encapsulated into a dedicated track.", "The setup and initialization information common to all tiles is encapsulated into a specific track, called for example the “tile base track”.", "The full video is thus encapsulated as a composition of all these tracks, namely the tile base track and the set of tile tracks.", "FIG.", "4 illustrates an exemplary encapsulation.", "One way to encapsulate tiled video according to the ISOBMFF standard is to split each tile into a dedicated track, to encapsulate the setup and initialization information common to all tiles in a specific track, called for example the “tile base track” and to encapsulate the full video as a composition of all these tracks: tile base track plus a set of tile tracks.", "The encapsulation is thus referred to as “multi-track tile encapsulation”.", "An example of multi-track tile encapsulation is provided in FIG.", "4.Box 401 represents the main ISOBMFF box ‘moov’ and contains the full list of tracks with their identifiers.", "For example, boxes 411 to 414 represent tile tracks (four tiles in the present example) and box 420 represents the tile base track.", "Additional tracks such as audio or text tracks may be used and encapsulated in the same file.", "However, for the sake of conciseness such additional tracks are not discussed here.", "As represented in FIG.", "4, the tile data is split into independent and addressable tracks so that any combination of tile track(s) can easily be reconstructed from the tile base track referencing the tile tracks for decoding and display.", "The tile base track may also be referred to as the “composite track” or “reference track” since it is designed to allow combination of any tiles: one, many or all tiles.", "The tile base track 420 contains common information to all the tile tracks and a list of samples 450 (only the first one is represented in FIG.", "4) in a “mdat” box.", "Each sample 450 of the tile base track 420 is built by reference to each tile track through the use of extractors (451 to 454 each one representing one extractor to each tile).", "Each tile track 411 to 414 represents a spatial part of the whole, or full-frame, video.", "The tile description (position, size, bandwidth etc.)", "is stored in the track header boxes (not represented) of each tile track 411 to 414.The tile base track and each tile track are cross-referenced (405) using a box “TrackReferenceBox” in each track.", "Each tile track 411 to 414 refers to the tile base track 420 as the ‘tbas’ track (‘tbas’ is a specific code indicating a coding dependency from each tile track to the tile base track, in particular where to find the parameter “HEVCDecoderConfigurationRecord” that makes it possible to setup the video decoder that will process the elementary stream resulting from the file format parsing).", "Conversely, in order to enable full-video reconstruction, the tile base track 420 indicates a dependency of type ‘scal’ to each tile track (405).", "This is to indicate the coding dependency and to reflect the sample 450 definition of the tile base track as extractors to the tile tracks data.", "These extractors are specific extractors that, at parsing time, can support the absence of data.", "In FIG.", "4, in order to provide a streamable version of the file, each track is decomposed into media segments (431 to 434 for the tile tracks and 460 for the tile base track).", "Each media segment comprises one or more movie fragments, indicated by the ‘moof’ box plus data.", "For tile tracks, the data part corresponds to a spatial sub-part of the video while for the tile base track, it contains the parameter sets, SEI messages when present and the list of extractors.", "The “moov” box 401 in case of streaming application would fit in an initialization segment.", "FIG.", "4 illustrates only one segment but the tracks can be decomposed into any number of segments, the constraint being that segments for tile tracks and for tile base track follow the same temporal decomposition (i.e.", "they are temporally aligned), this is to make switching possible from full-video to a tile or a set of tiles.", "The granularity of this temporal decomposition is not described here, for the sake of conciseness.", "The file format has descriptive metadata (such as “VisualSampleGroupEntries” for instance, or track reference types in ‘tref’ boxes) that describe the relationships between the tracks so that the data corresponding to one tile, a combination of tiles or all the tiles can easily be identified by parsing descriptive metadata.", "In what follows, still images are described at the same level.", "Thus, upon user selection of any tiles, combination of tiles or all tiles of a picture, identification and extraction is facilitated.", "In case the pictures are mixed with video data, the description comes in parallel to the descriptive metadata for the video.", "Thus, for the same data set, an additional indexation layer is provided for the pictures (in addition to the indexation layers for the video and for the audio).", "In still image file formats using ‘meta’ boxes, the pictures with the related information are described as information items.", "As illustrated in FIG.", "5, the information items are listed in a dedicated sub-box “ItemInfoBox” 500 of the ‘meta’ box.", "This sub-box provides the number of information items present in the file.", "The sub-box also provides for each item, descriptive metadata represented as “ItemInfoEntry” 501.Several versions 502 (0, 1, 2) of this box exist according to the ISO BMFF standard evolution.", "“Meta” items may not be stored contiguously in a file.", "Also, there is no particular restriction concerning the interleaving of the item data.", "Thus, two items in a same file may share one or several blocks of data.", "This is particularly useful for HEVC tiles (tiles can be stored contiguously or not), since it can make it straightforward to have one item per independently decodable tile.", "This item indicates the data offset in the main HEVC picture and length of the slice(s) used for the tile through an ItemLocationBox.", "According to embodiments, a new item type for describing a tile picture may be added, named for example: “hvct” or ‘tile’ or reused from ISO/IEC 14496-15: ‘hvt1’.", "Each item representing the tile picture (whatever the four character code chosen) may have a reference of type “tbas” to the ‘hvc1’ item from which it is extracted.", "Each item has an identifier “item_ID” 503 and is further described in a box “ItemLocationBox” in terms of byte position and size in the media data box containing the compressed data for the pictures.", "Such syntax makes it possible for a file format reader (or “parser”), to determine, via the list of information items, how many information items are available with information concerning their type 504, for example ‘tile’ to indicate an information item is a tile picture of a full picture.", "Thus, it is made possible to select a subset of information items in the file, a combination thereof, or the full set of information items in order to download only one tile of the image and the associated decoder configuration, while skipping the other tiles.", "For cases where an HEVC tile depends on another HEVC tile for decoding, the dependency shall be indicated by an item reference of type ‘dpnd’ (or any specific four character code that indicates coding dependencies) as described in document w14123, WD of ISO/IEC 14496-15:2013 AMD 1, “Enhanced carriage of HEVC and support of MVC with depth information”, MPEG 107 San Jose January 2014.This document defines tools for associating HEVC tile NALUs with sample group descriptions indicating the spatial position of the tile (using the “TileRegionGroupEntry” descriptor).", "However, there is no direct equivalent of sample grouping for metadata information items which could allow reuse of these descriptors.", "Therefore, according to embodiments, a tile description item is defined per tile and the tile is linked to its description using a modified version of the “ItemReferenceBox” box as explained below.", "According to other embodiments, only one tiling description is provided, preferably in a generic way.", "Thus, the item list does not get too long.", "The design may be as follows: allow some items to describe a set of metadata, similar to sample groups but specific to each item type, for any item, add the ability to describe one parameter for a given type of item reference.", "The parameter would then be interpreted depending on the type of the referred item (similar to grouping type).", "An upgrade of the descriptive metadata for an information item may be needed as explained in what follows with reference to FIG.", "6.According to the ISOBMFF standard, the sample grouping mechanism is based on two main boxes having a “grouping_type” parameter as follows: the box “SampleGroupDescriptionBox” has a parameter ‘sgpd’ that defines a list of properties (a list “SampleGroupEntry”), the box “SampleToGroupBox” has a parameter ‘sbgp’ that defines a list of sample group with their mapping to a property.", "The “grouping_type” parameter links a list of sample groups to a list of properties, the mapping of a sample group to one property in the list being specified in the box “SampleToGroupBox”.", "In order to provide the same functionality for the information items, a list of information items groups and a list of properties have to be described.", "Also, it should be made possible to map each group of information items to a property.", "In what follows, there is described how to make possible such descriptive metadata to be embedded in the Still Image File Format.", "In other words, how to link a descriptor to an image item.", "Even if the use cases are described for the HEVC Still Image File Format, the following features may be used in other standards such as ISO/IEC 14496-12 for associating any kind of information item with additional descriptive metadata.", "According to embodiments, the existing “ItemInformationEntry” box 601 with parameter ‘infe’ is extended with a new version number (602 and 603) in order to link each item to a property via a new parameter called “iref_type” 604 as shown in FIG.", "6.This makes it possible to avoid the creation of new boxes and improves the description while keeping it short.", "The original definition of ItemInformationEntry box is given by: if (version == 2) { unsigned int(16) item_ID; unsigned int(16) item_protection_index; unsigned int(32) item_type; string item_name ; if (item_type==’mime’) { string content_type; string content_encoding; //optional } else if (item_type == ‘uri ‘) { string item_uri_type; } } A new version making linking a tile picture to its description may be as follows: if ((version == 2) || (version == 3)) { unsigned int(16) item_ID; unsigned int(16) item_protection_index; unsigned int(32) item_type; string item_name; if (version == 2) { if (item_type==’mime’) { string content_type; string content_encoding; //optional } else if (item_type == ‘uri ‘) { string item_uri_type; } } if (version == 3) { unsigned int(32) item_iref_parameter_count; for (i=0 ; i< item_iref_parameter_count ; i++) { unsigned int(32) iref_type; unsigned int(32) iref_parameter; } } } According to other embodiments, closer to the box “SampleToGroupBox”, the definition of the box “ItemInformationBox” with four character code ‘iinf’ is changed as follows, for example by introducing a new version of this box: the current version: aligned(8) class ItemInfoBox extends FullBox(‘iinf’, version = 0, 0) { unsigned int(16) entry_count; ItemInfoEntry[ entry_count ] item_infos; } is changed into: aligned(8) class ItemInfoBox extends FullBox(‘iinf’, version = 1, 0) { unsigned int(16)group_entry_count; for (int g=0; g< group_entry_count;g++){ unsigned int(16) item_run; unsigned int(16) grouping_type; unsigned int(16) property_index; unsigned int(16) entry_count; ItemInfoEntry[ entry count ] item_infos; } unsigned int(16) remaining_entry_count; ItemInfoEntry[remaining_entry_count ] item_infos; } Alternatively, in order to signal whether group is in use or not, the current version is changed into: aligned(8) class ItemInfoBox extends FullBox(‘iinf’, version = 1, 0) { unsigned int(1)group_is_used; if (group_is_used == 0){ // standard iinf box but with 1 additional byte overhead unsigned int(7)reserved; // for byte alignment unsigned int(16) entry_count; ItemInfoEntry[ entry_count ] item_infos; } else { unsigned int(15)group_entry_count; for (int g=0; g< group_entry_count;g++){ unsigned int(16) item_run; unsigned int(16) grouping_type; unsigned int(16) property_index; unsigned int(16) entry_count; ItemInfoEntry[ entry_count ] item_infos; } unsigned int(16) remaining_entry_count; ItemInfoEntry[remaining_entry_count ] item_infos; } } The “group_entry_count” parameter defines the number of information items groups in the media file.", "For each group of information item, a number of information items is indicated, starting from item_ID=0.Since information items have no time constraints and relationships, contrary to the samples, the encapsulation module can assign the information item identifiers in any order.", "By assigning increasing identifiers numbers following the items group, the list of information group can be more efficiently represented using a parameter item_run identifying the runs of consecutive information items identifiers in a group.", "The related information items have an index called for example “property_index”.", "This “property_index” parameter associated with the “grouping_type” parameter enables a file format parser (or “reader”) to identify either a reference to descriptive metadata or the descriptive metadata itself.", "FIG.", "7 illustrates two exemplary embodiments.", "The group feature in box “SingleItemTypeReferenceBox” 701 may be used with a group identification “group_ID” instead of the information item identification (item_ID) that is usually used for the value of the from_item_ID parameter.", "By design, the box “SingleItemTypeReferenceBox” makes it easier to find all the references of a specific kind or from a specific item.", "Using it with a “group_ID” instead of “item_ID” makes it possible to find for a group of items to easily identify all the references of a specific type.", "Advantageously, since there is at most one box “ItemInformationBox” per encapsulated file, there is no need to define group identifications.", "An encapsulation module able to implement a method of encapsulating data according to the invention (during encoding) and a parsing module able to implement an method of processing an encapsulated data file according to the invention (during decoding) can run a respective counter (as the “g” variable in the box “ItemInformationBox) on the list of information item groups as they are created or read.", "Alternatively, the parser may be informed, using the flag “group_used_flag”, whether to maintain or not the group identification counter.", "Back to the example with one group of information items corresponding to the tile pictures, one group may contain four entries and the reference 700 “SingleItemTypeReference” may indicate the list of information items 704 on which the four tile picture information items depend, and so for a particular reference type 703.According to other exemplary embodiments, the information item is used in a new kind of box “ItemReferenceBox”, as described hereinafter, that makes it possible, from one item 722, to list multiple reference types 723 to various other information items 724.For the latter case, the specific box “ItemReferenceBox” 721 may be implemented as follows: aligned(8) class MultipleItemTypeReferenceBox(void) extends Box(void) { unsigned int(16) from_item_ID; unsigned int(16) reference_count; for (j=0; j<reference_count; j++) { unsigned int(32) reference_type; // new parameter to allow multiple types unsigned int(16) to_item_ID; } } As for the standard box “ItemInformationBox”, the list of item entries is described, but this time with a different order depending on the grouping.", "In the tile example, this may lead to a first group of four information items corresponding to the tile pictures gathered in a group with a parameter that may be named ‘tile’ followed by non-grouped information items for the configuration information, for the full picture information item and optionally for the EXIF metadata.", "Thus, one box is modified and one box is created that is a specific kind of ItemReferenceBox.", "In what follows, this new kind of ItemReferenceBox is described.", "The box “ItemReferenceBox” may also be extended by distinguishing between the various kinds of ItemReferenceBox by using the flag parameters in the box “FullBox” which is part of the ItemReferenceBox as follows: aligned(8) class ItemReferenceBox extends FullBox(‘iref’, 0, flags) { switch (flags) { case 0: SingleItemTypeReferenceBox references[ ]; break; case 1: MultipleItemTypeReferenceBox references[ ]; break; case 2: SharedItemTypeReferenceBox references[ ]; break; } } Using the box “MultipleItemTypeReferenceBox” 721, one picture with four tiles may be described as follows: Item Reference Box (version=1 or flags=1): fromID=2, ref_count=1, type=‘cdsc’, toID=1; fromID=1, ref_count=1, type=‘init’, toID=3; fromID=4, ref_count=2, type=‘tbas’, toID=1, type=‘tile’ toID=8; fromID=5, ref_count=2, type=‘tbas’, toID=1, type=‘tile’ toID=8; fromID=6, ref_count=2, type=‘tbas’, toID=1, type=‘tile’ toID=8; fromID=7, ref_count=2, type=‘tbas’, toID=1, type=‘tile’ toID=8; This design makes it fairly easier to find all the references of any kinds from a specific item.", "Description support 711 for a list of items 712 referencing a same item 714 with a given type 713 may be as follows: aligned (8) class SharedItemTypeReferenceBox(ref_type) extends Box(referenceType) { unsigned int(16) reference_count; for (j=0; j<reference_count; j++) { unsigned int(16) from_item_ID; } unsigned int(16) to_item_ID; } } In the example of a picture with four tiles, then we may have: type=‘cdsc’, ref_count=1, fromID=2, toID=1; type=‘init’, ref_count=1, fromID=1, toID=3; type=‘tbas’, ref_count=4, fromID=4, fromID=5, fromID=6, fromID=7, toID=1; type=‘tile’, ref_count=4, fromID=4, fromID=5, fromID=6, fromID=7, toID=8; The design of the box “SharedItemTypeReferenceBox” makes it easier to find all the references of a specific type pointing to a specific item.", "This is in contrast with box “SingleItemTypeReferenceBox”.", "But since most of the “reference type” defined for track references are not bi-directional, the box “SingleItemTypeReferenceBox” may not be used with some unidirectional reference type to signal all nodes having this reference type to other items.", "Alternatively, a flag may be provided in the “SingleItemTypeReference” for indicating whether it is a direct reference or a reverse reference, thereby alleviating the need for the new SharedItemTypeReferenceBox.", "In view of the above, an information item can be associated with tiling information.", "A description of this tiling information has now to be provided.", "For example, each tile may be described using a tile descriptor, such as the “iref_parameter” 605 of the extended “ItemInfoEntry” 601.A specific descriptor may be as follows: aligned(8) class TileInfoDataBlock( ) { unsigned int(8) version; unsigned int(32) reference_width; // full image sizes unsigned int(32) reference_height; unsigned int(32) horizontal_offset; // tile positions unsigned int(32) vertical_offset; unsigned int(32) region_width; // tile sizes unsigned int(32) region_height; } According to embodiments, a descriptor may be used for the grid of tiles to apply to the one or more pictures to be stored.", "Such descriptor may be as follows: aligned(8) class TileInfoDataItem ( ) { unsigned int(8) version; unsigned int(1) regular_spacing; // regular grid or not unsigned int(7) reserved = 0; unsigned int(32) reference_width; // full-frame sizes unsigned int(32) reference_height; unsigned int(32) nb_cell_horiz; unsigned int(32) nb_cell_vert; if (!regular_spacing) { for (i=0; i<nb_cell_width; i++) unsigned int(16) cell_width; for (i=0; i<nb_cell_height; i++) unsigned int(16) cell_height; } } } This descriptor “TileInfoDataItem” allows describing a tiling grid (regular or irregular).", "The grid is described rows by rows starting from top-left.", "The descriptor shall be stored as an item of type ‘tile’.", "When another item refers to this item, it shall use a reference of type “tile” to this description and it shall have a parameter “iref_parameter” specified, whose value is the 0-based index of the cell in the grid defined by the descriptor, where 0 is the top-left item, 1 is the cell immediately to the right of cell 0 and so on.", "In the descriptor: “version” indicates the version of the syntax for the TileInfoDataItem.", "Only value 0 is defined.", "“regular_spacing” indicates if all tiles in the grid have the same width and the same height.", "“reference_width, reference_height” indicates the units in which the grid is described.", "These units may or may not match the pixel resolution of the image which refers to this item.", "If the grid is regular, the “reference_width” (resp.", "“reference_height”) shall be a multiple of “nb_cell_horiz” (resp.", "“nb_cell_vert”).", "“cell_width” gives the horizontal division of the grid in non-regular tiles, starting from the left.", "“cell_height” gives the vertical division of the grid in non-regular tiles, starting from the top.", "The above approach makes it possible to share the tiling information for all tiles.", "Moreover, in case there are multiple pictures sharing the same tiling, even more description may be shared by simply referencing a cell in the grid of tiles.", "The tiling configuration can be put in the media data box or in a dedicated box shared (by reference) among the tile information items.", "The above descriptors are pure spatial descriptors in the sense that they only provide spatial locations and sizes for sub-image(s) in a greater image.", "In some use cases, for example with image collections or image composition, a spatial location is not enough to describe the image, typically when images overlap.", "This is one limitation of the TileInfoDataBlock descriptor above.", "In order to allow image composition, whatever the image i.e.", "a tile or an independent/complete image, it may be useful to define a descriptor that contains on the one hand the positions and sizes of the image (spatial relations) and on the other hand display information (color, cropping .", ".", ". )", "for that picture.", "For example, color information can be provided to transform a sub-image from a color space to another one for display.", "This kind of information can be conveyed in the ColorInformationBox ‘colr’ of the ISOBMFF.", "It can be useful, for compacity, to have the same data prepared for different kinds of display just by providing the transformation parameters to apply rather than conveying the two different so-transformed pictures.", "As well, the pixel aspect ratio like PixelAspectRatio box ‘pasp’ defined in the ISOBMFF Part-12 can be put in this descriptor to redefine a width and height that can be different than the encoded width and height of each picture.", "This would indicate the scale ratio to apply by the display after the decoding of an image.", "We would then have the coded sizes stored in the video sample entries (‘stsd’ box for example) and the display sizes deduced from the ‘pasp’ box.", "Another possible information for display could be the clean aperture information box ‘clap’ also defined in ISOBMFF.", "According to standard SMPTE 274M, the clean aperture defines an area within which picture information is subjectively uncontaminated by all edge transient distortions (possible ringing effects at the borders of images after analog to digital conversions).", "This list of parameters useful for display is not limitative and we could put as optional components in the sub-image descriptor any other descriptive metadata box.", "These ones can be explicitly mentioned because they are already part of the standard and they provide generic tools to indicate image cropping, sample aspect ratio modification and color adjustments.", "Unfortunately their use was only possible for media tracks, not for image file format relying on ‘meta’ boxes.", "We then suggest a new descriptor called for example “SimpleImageMetaData” to support spatial description of image items, along with other properties such as clean aperture or sample aspect ratio or any other display parameters.", "This applies to any sub-image (tile or independent image) intended to be composed in a bigger image or at the reverse extracted from a bigger image: aligned(8) class SimpleImageMetaData { CleanApertureBox clap; // optional PixelAspectRatioBox pasp; // optional ColourInformationBox colour; // optional ImageSpatialRelationBox location; // optional } Or its variation when considering extension parameters to help the display process (through for example extra_boxes): aligned(8) class SimpleImageMetaData { CleanApertureBox clap; // optional PixelAspectRatioBox pasp; // optional ColourInformationBox colour; // optional ImageSpatialRelationBox location; // optional extra_boxes boxes; // optional } Where the ImageSpatialRelationBox is an extension of the TileInfoDataBlock as described in the following.", "Another useful parameter to consider is the possibility to compose images as layers.", "We then suggest inserting a parameter to indicate the level associated to an image in this layered composition.", "This is typically useful when images overlap.", "This can be called ‘layer’ for example with layer information indication.", "An example syntax for such descriptor is provided: Definition: Box Type: ‘isre’ Container: Simple image meta-data item (‘simd’) Mandatory: No Quantity: Zero or one per item Syntax: aligned(8) class ImageSpatialRelationBox extends FullBox(‘isre, version = 0, 0) { unsigned int(32) horizontal_display_offset; unsigned int(32) vertical_display_offset; unsigned int(32) display_width; unsigned int(32) display_height; int(16) layer; } with the associated semantics: horizontal_display_offset specifies the horizontal offset of the image.", "vertical_display_offset specifies the vertical offset of the image.", "display_width specifies the width of the image.", "display_height specifies the height of the image.", "layer specifies the front-to-back ordering of the image; images with lower numbers are closer to the viewer.", "0 is the normal value, and −1 would be in front of layer 0, and so on This new ‘isre’ box type gives the ability to describe the relative position of an image with other images in an image collection.", "It provides a subset of the functionalities of the transformation matrix usually found in the movie or track header box of a media file.", "Coordinates in the ImageSpatialRelationBox are expressed on a square grid giving the author's intended display size of the collection; these units may or may not match the coded size of the image.", "The intended display size is defined by: Horizontally: the maximum value of (horizontal_display_offset+display_width) for all ‘isre’ boxes Vertically: the maximum value of (vertical_display_offset+display_height) for all ‘isre’ boxes When some images do not have any ‘isre’ associated while other images in the file have ‘isre’ associated, the default images without any ‘isre’ shall be treated as if their horizontal and vertical offsets are 0, their display size is the intended display size and their layer is 0.The ImageSpatialRelationBox indicates the relative spatial position of images after any cropping or sample aspect ratio has been applied to the images.", "This means, when ‘isre’ is combined with ‘pasp’, etc in a SimpleImageMetaData, the image is decoded, the ‘pasp’, ‘clap’, ‘colr’ are applied if present and then the image is moved and scaled to the offset and size declared in the ‘isre’ box.", "This new descriptor can be used as description of an image (tile or single image) by defining an association between the item information representing the image and the item information representing the descriptor (let's give the type ‘simd’ for SimpleImageMetadata Definition, any reserved 4 character code would be acceptable for a mp4 parser to easily identify the kind of metadata it is currently processing).", "This association is done with an ItemRefererenceBox and with a new reference type; ‘simr’ to indicate “spatial image relation”.", "The example description below illustrates the case of a composition of 4 images where the composition itself has no associated item.", "Each image item is associated to a SimpleImageMetaData item through an item reference of type ‘simr’ and shares the DecoderConfigurationRecord information in a dedicated ‘hvcC’ item.", "ftyp box: major-brand = ‘hevc’, compatible-brands = ‘hevc’ meta box: (container) handler box: hdlr = ‘hvc1’ // no primary item provided Item Information Entries: item_type = ‘hvc1’, itemID=1, item_protection_index = 0 item_type = ‘hvc1’, itemID=2, item_protection_index = 0 item_type = ‘hvc1’, itemID=3, item_protection_index = 0 item_type = ‘hvc1’, itemID=4, item_protection_index = 0 item_type=‘simd’ itemID=5 (sub-image descriptor) item_type=‘simd’ itemID=6 (sub-image descriptor) item_type=‘simd’ itemID=7 (sub-image descriptor) item_type=‘simd’ itemID=8 (sub-image descriptor) item_type = ‘hvcC’, item_ID=9, item_protection_index = 0...", "Item Reference: type=‘simr’ fromID=1, toID=5 type=‘simr’ fromID=2, toID=6 type=‘simr’ fromID=3, toID=7 type=‘simr’ fromID=4, toID=8 type=‘init’, fromID=1, toID=9; type=‘init’, fromID=3, toID=9; type=‘init’, fromID=4, toID=9; type=‘init’, fromID=5, toID=9; Item Location: itemID = 1, extent_count = 1, extent_offset = P1, extent_length = L1; itemID = 2, extent_count = 1, extent_offset = P2, extent_length = L2; itemID = 3, extent_count = 1, extent_offset = P3, extent_length = L3; itemID = 4, extent_count = 1, extent_offset = P4, extent_length = L4; itemID = 5, extent_count = 1, extent_offset = P5, extent_length = L5; itemID = 6, extent_count = 1, extent_offset = P6, extent_length = L6; itemID = 7, extent_count = 1, extent_offset = P7, extent_length = L7; itemID = 8, extent_count = 1, extent_offset = P8, extent_length = L8; itemID = 9, extent_count = 1, extent_offset = P0, extent_length = L0; Media data box: 1 HEVC Decoder Configuration Record (‘hvcC’ at offset P0) 4 HEVC Images (at file offsets P1, P2, P3, P4) 4 simple image metadata (at file offsets P5, P6, P7, P8) The above organization of data is provided as an example: image and metadata could be interlaced in the media data box for example to have an image plus its metadata addressable as a single byte range.", "When receiving this description, a parser is informed, by parsing the information in the ‘simd’ items whether a sub-image is cropped from a full picture, or conversely if a full picture is a composition from sub-images.", "In case of crop, the full picture item and the cropped image would share the same data range as in example below and the same decoder configuration information.", "The sub-image would then be associated to a ‘simd’ item having only ‘clap’ information and no positioning, then no ‘isre’.", "In case of composition: in such case, the full picture item is associated to a ‘simd’ item that only contains ‘isre’ information and the sub-image would be associated to a ‘simd’ item reflecting its position in the full image.", "The example below illustrates the case where 4 images are composed into a larger one.", "All images, including the composed one are exposed as a playable item using the proposed descriptor.", "ftyp box: major-brand = ‘hevc’, compatible-brands =‘mif1’ meta box: (container) handler box: hdlr = ‘hevc’ primary item box: item_ID = 1; Item Information Entries: item_type = ‘hvc1’, itemID=1, item_protection_index = 0... // full-image item_type = ‘hvc1’, itemID=2, item_protection_index = 0... // sub-image item_type = ‘hvc1’, itemID=3, item_protection_index = 0... // sub-image item_type = ‘‘hvc1’, itemID=4, item_protection_index = 0... // sub-image item_type = ‘hvc1’, itemID=5, item_protection_index = 0... // sub-image item_type = ‘simd’ itemID=6 (sub-image descriptor)... item_type = ‘simd’ itemID=7 (sub-image descriptor)... item_type = ‘simd’ itemID=8 (sub-image descriptor)... item_type = ‘simd’ itemID=9 (sub-image descriptor)... item_type = ‘hvcC’, item_ID=10 (decoder config record) item_type = ‘simd’, item_ID=11 (sub-image descriptor) Item Reference Entries: type= ‘simr’, fromID=1, toID=11 type= ‘simr’, fromID=2, toID=6 type= ‘simr’, fromID=3, toID=7 type= ‘simr’, fromID=4, toID=8 type= ‘simr’, fromID=5, toID=9 type= ‘init’, fromID=1, toID=10... type= ‘init’, fromID=2, toID=10... type= ‘init’, fromID=3, toID=10... type= ‘init’, fromID=4, toID=10... type= ‘init’, fromID=5, toID=10...", "Item Location: itemID = 1, extent_count = 4,// full image is composed of 4 sub-images extent_offset = P2, extent_length = L2; extent_offset = P3, extent_length = L3; extent_offset = P4, extent_length = L4; extent_offset = P5, extent_length = L5; itemID = 2, extent_count = 1, extent_offset = P2, extent_length = L2; itemID = 3, extent_count = 1, extent_offset = P3, extent_length = L3; itemID = 4, extent_count = 1, extent_offset = P4, extent_length = L4; itemID = 5, extent_count = 1, extent_offset = P5, extent_length = L5; itemID = 6, extent_count = 1, extent_offset = P6, extent_length = L6; itemID = 7, extent_count = 1, extent_offset = P7, extent_length = L7; itemID = 8, extent_count = 1, extent_offset = P8, extent_length = L8; itemID = 9, extent_count = 1, extent_offset = P9, extent_length = L9; itemID = 10, extent_count =1, extent_offset = P0, extent length = L0; itemID = 11, extent_count = 1, extent_offset = P10, extent_length = L10; Media data box: 1 HEVC Decoder Configuration Record (‘hvcC’ at offset P0) 4 HEVC (sub) Images (at file offsets P2, P3, P4, P5) 5 simple image metadata (at file offsets P6, P7, P8, P9, P10) This other example illustrates the case where the full picture is actually a tiled HEVC picture (4 tiles): ftyp box: major-brand = ‘hevc’, compatible-brands = ‘mif1’ meta box: (container) handler box: hdlr = ‘hevc’ primary item box: item_ID = 1; Item Information Entries: item_type = ‘hvc1’, itemID=1, item_protection_index = 0... // full-image item_type = ‘hvt1’, itemID=2, item_protection_index = 0... // sub-image item_type = ‘hvt1’, itemID=3, item_protection_index = 0... // sub-image item_type = ‘hvt1’, itemID=4, item_protection_index = 0... // sub-image item_type = ‘hvt1’, itemID=5, item_protection_index = 0... // sub-image item_type = ‘simd’ itemID=6 (sub-image descriptor)... item_type = ‘simd’ itemID=7 (sub-image descriptor)... item_type = ‘simd’ itemID=8 (sub-image descriptor)... item_type = ‘simd’ itemID=9 (sub-image descriptor)... item_type = ‘hvcC’, item_ID=10 (decoder config record) Item Reference Entries: type= ‘init’, fromID=1, toID=10... // declare sub-images as tiles of the full image type= ‘tbas’, fromID=2, toID=1... type= ‘tbas’, fromID=3, toID=1... type= ‘tbas’, fromID=4, toID=1... type= ‘tbas’, fromID=5, toID=1... // providing positions and sizes type= ‘simr’, fromID=2, toID=6 type= ‘simr’, fromID=3, toID=7 type= ‘simr’, fromID=4, toID=8 type= ‘simr’, fromID=5, toID=9 Item Location: itemID = 1, extent_count = 4,// full image is composed of 4 tiles extent_offset = P2, extent_length = L2... // data for tile 1 extent_offset = P3, extent_length = L3... // data for tile 2 extent_offset = P4, extent_length = L4... // data for tile 3 extent_offset = P5, extent_length = L5... // data for tile 4 itemID = 2, extent_count = 1, extent_offset = P2, extent_length = L2; itemID = 3, extent_count = 1, extent_offset = P3, extent_length = L3; itemID = 4, extent_count = 1, extent_offset = P4, extent_length = L4; itemID = 5, extent_count = 1, extent_offset = P5, extent_length = L5; itemID = 6, extent_count = 1, extent_offset = P6, extent_length = L6; itemID = 7, extent_count = 1, extent_offset = P7, extent_length = L7; itemID = 8, extent_count = 1, extent_offset = P8, extent_length = L8; itemID = 9, extent_count = 1, extent_offset = P9, extent_length = L9; itemID = 10, extent_count = 1, extent_offset = P0, extent length = L0; Media data box: 1 HEVC Decoder Configuration Record (‘hvcC‘ at offset P0) 1 HEVC Image (with 4 tiles at file offsets P2, P3, P4, P5) 4 simple image metadata (at file offsets P6, P7, P8, P9) Depending on use cases, it would be possible to have several image items sharing the same metadata, for example when the same cropping is to be applied to all images.", "It is also possible for an image item to have multiple ‘simr’ references to different SimpleImageMetaData, for example when cropping is shared among images but not spatial information.", "An alternative embodiment to the new version of the ItemInfoEntry (as illustrated in FIG.", "6) is to define more than one parameter (605) per information item entry and reference.", "In the embodiment of FIG.", "6, the iref_parameter is a four bytes code that is useful in case of a tile index to refer to a cell in a tiling grid.", "But in order to have richer description and to be able to embed linked description inside the item info entry itself rather than with the data (in mdat box), the following extension can be useful: if (version == 3) { unsigned int (32) item_iref_parameter_count; for (i=0 ; i< item_iref_parameter_count ; i++) { unsigned int(32) iref_type; ItemReferenceParameterEntry parameter; } aligned(8) abstract class ItemReferenceParameterEntry (unsigned int(32) format) extends Box(format){ } // Example to reference a tile index aligned(8) abstract class TileIndexItemReferenceParameterEntry extends ItemReferenceParameterEntry(‘tile’){ unsigned int(32) tile_index; } // Example to inline the tile description aligned(8) abstract class TileIndexItemReferenceParameterEntry extends ItemReferenceParameterEntry‘tile'){ unsigned int(32) tile_index; } In the above extension: item_iref_parameter_count gives the number of reference types for which a parameter is given.", "This is unchanged compared to item 605 in FIG.", "6, iref_type gives the reference type, as indicated in the ‘iref’ box, for which the parameter applies for this item.", "This is unchanged compared to item 605 in FIG.", "6.parameter here differs from iref_parameter (item 605 in FIG.", "6) because it provides an extension means via the new box ItemReferenceParameterEntry.", "By specializing this new box (as done above with TileIndexItemReferenceParameterEntry for tile index in a tiling configuration), any kind of additional metadata can be associated with an information item entry provided that the encapsulation and the parsing modules are aware of the structure of this specialized box.", "This can be done by standard types of ItemReferenceParameterEntry or by providing by construction or in a negotiation step the structure of the parameter entry.", "The semantics of the parameter is given by the semantics of the item with type iref_type.", "In what follows, there are provided exemplary descriptive metadata for information items describing a picture with 4 tiles and the EXIF meta data of the full picture.", "In the prior art, the tile pictures were listed as information items without any corresponding description provided as show herein below.", "Moreover, the setup information denoted ‘hvcC’ type was not described as an item.", "This makes it possible to factorize the common data related to HEVC parameter sets and SEI messages that apply to all tile pictures and to the full picture.", "ftyp box: major-brand = ‘hevc’, compatible-brands = ‘hevc’ meta box: (container) handler box: hdlr = ‘hvc1’ primary item: itemID = 1; Item information: item_type = ‘hvc1’, itemID=1, item_protection_index = 0 (unused) => Full pict.", "item_type = ‘Exif’, itemID=2, item_protection_index = 0 (unused) item_type = ‘hvcC’, itemID=3, item_protection_index = 0 (unused) item_type = ‘hvct’, itemID=4, item_protection_index = 0 (unused) => Tile pict.", "item_type = ‘hvct’, itemID=5, item_protection_index = 0 (unused) => Tile pict.", "item_type = ‘hvct’, itemID=6, item_protection_index = 0 (unused) => Tile pict.", "item_type = ‘hvct’, itemID=7, item_protection_index = 0 (unused) => Tile pict.", "Item Location: itemID = 1, extent count = 1, extent_offset = X, extent_length = Y; itemID = 2, extent_count = 1, extent_offset = P, extent_length = Q; itemID = 3, extent_count = 1, extent_offset = R, extent_length = S; itemID = 4, extent_count = 1, extent_offset = X, extent_length = ET1; itemID = 5, extent_count = 1, extent_offset = X+ET1, extent_length = ET2; itemID = 6, extent_count = 1, extent_offset = X+ET2, extent_length = ET3; itemID = 7, extent_count = 1, extent_offset = X+ET3, extent_length = ET4; Item Reference: type=‘cdsc’, fromID=2, toID=1; type=‘init’, fromID=1, toID=3; type=‘tbas’, fromID=4, toID=1; type=‘tbas’, fromID=5, toID=1; type=‘tbas’, fromID=6, toID=1; type=‘tbas’, fromID=7, toID=1; Media data box: HEVC Image (at file offset X, with length Y) Exif data block (at file offset P, with length Q) HEVC Config Record (at file offset R, with length S) // No Tile description According to embodiments, using the extension with version 3 (see FIG.", "6, 602, 603) of ItemInfoEntry box (601): tile picture information is listed with associated references to parts of the tiling configuration that is also described as an information item (ID=8).", "ftyp box: major-brand = ‘hevc’, compatible-brands = ‘hevc’ meta box: (container) handler box: hdlr = ‘hvc1’ primary item: itemID = 1; Item information: item_type = ‘hvc1’, itemID=1, item_protection_index = 0 (unused) item_type = ‘Exif’, itemID=2, item_protection_index = 0 (unused) item_type = ‘hvcC’, itemID=3, item_protection_index = 0 (unused) item_type = ‘hvct’, itemID=4, parameter for ireftype==tile: tile_index=0 item_type = ‘hvct’, itemID=5, parameter for ireftype==tile: tile_index=1 item_type = ‘hvct’, itemID=6, parameter for ireftype==tile: tile_index=2 item_type = ‘hvct’, itemID=7, parameter for ireftype==tile: tile_index=3 item_type = ‘tile’, itemID=8, (tiling configuration) Item Location: itemID = 1, extent_count = 1, extent_offset = X, extent_length = Y; itemID = 2, extent_count = 1, extent_offset = P, extent_length = Q; itemID = 3, extent_count = 1, extent_offset = R, extent_length = S; itemID = 4, extent_count = 1, extent_offset = X, extent_length = ET1; itemID = 5, extent_count = 1, extent_offset = X+ET1, extent_length = ET2; itemID = 6, extent_count = 1, extent_offset = X+ET2, extent_length = ET3; itemID = 7, extent_count = 1, extent_offset = X+ET3, extent_length = ET4; itemID = 8, extent_count = 1, extent_offset = i, extent_length = I; Item Reference: type=‘cdsc’, fromID=2, toID=1; type=‘init’, fromID=1, toID=3; type=‘tbas’, fromID=4, toID=1; type=‘tbas’, fromID=5, toID=1; type=‘tbas’, fromID=6, toID=1; type=‘tbas’, fromID=7, toID=1; type=‘tile’, fromID=4, toID=8; // type=‘tile’, fromID=5, toID=8; // link each tile pict.", "type=‘tile’, fromID=6, toID=8; // to the tiling config item type=‘tile’, fromID=7, toID=8; // Media data box: HEVC Image (at file offset X, with length Y) Exif data block (at file offset P, with length Q) HEVC Config Record (at file offset R, with length S) Tile description data block (at file offset i, with length I) FIG.", "8 illustrates a context of implementation of embodiments of the invention.", "First different media are recorded: for example audio during step 800a, video during step 800b and one or more pictures during step 800c.", "Each medium is compressed during respective steps 801a, 801b and 801c.", "During these compression steps elementary streams 802a, 802b and 802c are generated.", "Next, at application level (user selection from graphical user interface; configuration of the multimedia generation system etc.", "), an encapsulation mode is selected in order to determine whether or not all these elementary streams should be merged or not.", "When the “merge” mode is activated (test 803, “yes”), data for audio, video and still images are encapsulated in the same file during step 806c as described hereinabove.", "If the “merge” mode is not activated (test 803, “no”), then two encapsulated files are generated during steps 806a and 806b consecutively or in parallel thereby respectively leading to the creation of one file for synchronized time media data during step 807a and an additional file with only the still images 907b.", "During step 806a, audio and video elementary streams are encapsulated according to the ISOBMFF standard and the still pictures are encapsulated during step 806b as described herein above in order to provide tile description and region of interest features.", "Finally, a media presentation 807 is obtained and can be provided to a DASH generator to prepare it for streaming (step 820a) or stored into a memory (step 820b) or rendered on a display unit (step 820c) or transmitted (step 820d) to a remote entity either entirely or after some parts (such as tiles), have been extracted by parsing the descriptive metadata.", "According to another embodiment, it is proposed a new ‘hvco’ item for allowing the composition of sub-image pictures, in particular sub-image pictures which belong to at least two different pictures.", "In this case, the primary item is a composed image.", "More specifically, based on the definition of the HEVC Still Image File Format, no simple solutions are provided when composing sub-image pictures, in particular when pictures come from different HEVC pictures having different decoder configuration information (shared by the dedicated ‘hvcC’ item).", "One solution for composing sub-images picture is depicted in text above related to FIG.", "7.The composite image is declared as an ‘hvc1’ item.", "This ‘hvc1’ item required an ‘hvcC’ item according to still image File Format.", "But when the pictures where the sub-images come from are associated with different or incompatible decoder configuration information, there is no “hvcC” item which could correspond to the resulting HEVC composite image.", "A new solution illustrated in FIG.", "9 is provided by the present invention.", "During a first step 900, sub-image pictures to use in the composition (for example compressed with HEVC) are collected.", "During a step 901 each one is described as an HEVC image item using for instance a code as defined above, here named ‘hvc1’.", "Still during step 901, the decoder configuration information of each sub-image picture is described as an initialization item using for example the ‘hvcC’ item described above.", "Both sub-image picture item and initialization data are linked via an ItemReferenceBox described above with reference to FIG.", "7.It has to be noted that each sub-image picture can have its own initialization data, i.e.", "one hvcC item per sub-image, or all sub-images can share the same initialization data as on the description example below.", "The latter occurs when sub-image pictures correspond to tiles from a same picture.", "During a step 902 a composed picture is built, for example by a user through the user interface of an image manipulation tools.", "The user can bring parts of pictures together so as to create a composite picture (or composed picture) mixing spatial full or subparts of the sub-image pictures.", "The respective position and sizes of the selected sub-parts are saved by the picture manipulation tool and provided to the server in charge of encapsulating the composite image in order to insert them in the encapsulation data file for terminating step 902.The image manipulation tool may comprise a Graphical User Interface for processing (cropping, resizing, filtering .", ".", ". )", "an image.", "In case the user produced more than one composite picture (test 903), a list of dependencies between each composite picture and the used sub-image pictures is built during 904.Then during a step 905, the composite picture defined by the user as the preferred image to display by default is described in dedicated file for example through a primary item box, already described above.", "Then during a step 906, a comparison is drawn (by the encapsulation module) in order to compare the initialization data needed for each sub-image picture composing the composite picture (mainly decoder configuration information like profiles, levels, number of bits per pixels .", ".", ".", ").", "These are checked to determine whether they are compatible or not.", "In order to help the comparison, a checksum for each parameter set can be generated at encapsulation of each sub-image and stored either with textual description in user metadata box linked to the sub-image item or in a modified version of the decoder configuration information, with the NAL units representing the various parameter sets of the image bitstream.", "The comparison when done a posteriori can be facilitated.", "This is the object of a test at step 907.Typically in HEVC Still Image File format, information related to initialization data are stored in a dedicated item with type ‘hvcC’ and reflects the properties of the HEVC bitstream.", "For example, the initialization data of two distinct sub-image pictures are considered as being compatible when the set of HEVC tools in use (profile, level .", ".", ". )", "is the same, as well as the image data representation format (number of bits per pixel .", ".", ".", ").", "If all the initialization data is compatible (908), then the composite picture can be linked to one of the initialization data item of a sub-image picture or to an initialization data item shared by all sub-image pictures (step 907).", "As mentioned above, this can be done with an ItemReferenceBox and an ‘init’ reference type or any other means to indicate initialization data.", "Moreover the corresponding image item for the composite picture can be described as an HEVC item type, for example using the ‘hvc1’ code.", "If the initialization data items are not compatible (909), then the composite picture has no initialization data associated.", "A specific signaling is required.", "For example an ‘hvco’ code or any reserved code to indicate an HEVC composition of sub-image pictures and the corresponding initialization data has to be retrieved from each sub-image picture used for composing the composite picture.", "At the end, since there could be many composite pictures, each composite picture may be linked to its corresponding list of sub-image pictures through an item reference box in 910.This consists in declaring for each composite picture the list of dependencies built during step 904 with an ItemReferenceBox of type ‘base’ (as defined in the draft for international standard for Still Image File Format w14642) or ‘tile’ (as described in previous embodiments) or any dedicated four character code (for compliance with file format) indicating that the composite picture is generated from or uses this list of sub-image pictures.", "Finally in step 911, display offsets (for instance comprising vertical and horizontal positions of the top left corner of the image) and display sizes for the composite picture are described (‘simd’ code for example and descriptor for spatial relation like “SimpleImageMetaData” introduced in previous embodiments or like ISOBMFFMetaData (defined in w14642) or any equivalent descriptor for display parameters).", "The last description parameter is about data location in the bitstream, i.e.", "in the ‘mdat’ box.", "This can be provided for example with the ItemLocationBox.", "In case of composite picture, data location may simply consists in listing the data position of the sub-image pictures or when not present let the parser get these information from the list of dependent sub-image picture.", "The same process goes when there is only one composite picture from 903 (false) to 912-917 except that there is no need to describe the dependency list, assuming that by default all the sub-image pictures having spatial relationship description (for example ‘isre’ with non null display sizes) are involved in the composition.", "The description example below illustrates when a user would like to expose a composite picture as the primary item in a multimedia file for player to directly render this composite image.", "This example corresponds to the case where initialization data of the different sub-image pictures composing the composite picture are not compatible.", "Indeed the first two sub-image pictures share common initialization data (item 9) while the two other sub image pictures (items 3 and 4) share other initialization data (item 12).", "This may be the case when parameter sets for the image bitstream are embedded in the decoder configuration information.", "Then the composite picture is described as an ‘hvco’ item and also indicates the display size of the resulting composition in an item 11.The location of the data is here not described, deduced from the four sub-image pictures since only one composition is described in the encapsulated file.", "ftyp box: major-brand = ‘hevc’, compatible-brands = ‘mif1’ meta box: (container) handler box: hdlr = ‘hevc’ primary_item box: item_ID = 10 Item Information Entries: item_type = ‘hvc1’, itemID=1 (sub-image) item_type = ‘hvc1’, itemID=2 (sub-image) item_type = ‘hvc1’, itemID=3 (sub-image) item_type = ‘hvc1’, itemID=4 (sub-image) item_type=‘simd’ itemID=5 (sub-image 1 descriptor, same isre as in example 2) item_type=‘simd’ itemID=6 (sub-image 2 descriptor, same isre as in example 2) item_type=‘simd’ itemID=7 (sub-image 3 descriptor, same isre as in example 2) item_type=‘simd’ itemID=8 (sub-image 4 descriptor, same isre as in example 2) item_type = ‘hvcC’, item_ID=9 (decoder config, shared among 2 sub-images) item_type = ‘hvco’, itemID=10 (the composite image) item_type=‘simd’ itemID=11 (composite image, isre = {0, 0, 640, 384, 0}) item_type =‘hvcC’, item_ID=12 (decoder config, shared among 2 sub-images) Item Reference: type=‘simr’ from_item_ID=1, to_item_ID=5 type=‘simr’ from_item_ID=2, to_item_ID=6 type=‘simr’ from_item_ID=3, to_item_ID=7 type=‘simr’ from_item_ID=4, to_item_ID=8 type=‘simr’, from_item_ID=9, reference_count=2, to_item_ID=1, 2 type=‘init’, from_item_ID=12, reference_count=2, to_item_ID=3, 4 type=‘simr’ from_item_ID=10, to_item_ID=11 Item Location: itemID = 1, extent_count = 1, extent_offset = P1, extent_length = L1; itemID = 2, extent_count = 1, extent_offset = P2, extent_length = L2; itemID = 3, extent_count = 1, extent_offset = P3, extent_length = L3; itemID = 4, extent_count = 1, extent_offset = P4, extent_length = L4; itemID = 5, extent_count = 1, extent_offset = P5, extent_length = L5; itemID = 6, extent_count = 1, extent_offset = P6, extent_length = L6; itemID = 7, extent_count = 1, extent_offset = P7, extent_length = L7; itemID = 8, extent_count = 1, extent_offset = P8, extent_length = L8; itemID = 9, extent_count = 1, extent_offset = P0, extent_length = L0; Media data box: 1 HEVC Decoder Configuration Record (‘hvcC’ at offset P0) 4 HEVC Images (at file offsets P1, P2, P3, P4) 4 Simple Image Metadata items (at file offsets P5, P6, P7, P8) Another example of description file below illustrates a composition where the sub images share the same hvcC item.", "This may happen when parameter sets for the image bitstream are not present in the decoder configuration information.", "In this case, in a preferred embodiment the composite image is declared with type ‘hvco’ plus a reference to the shared ‘hvcC’ item.", "The ‘hvcC’ item warns the player about profile, level, bit depth information.", "It also indicates that the composite picture is not really an HEVC picture (if HEVC standard is considered) by itself but rather several HEVC sub-images to be decoded and displayed together.", "ftyp box: major-brand = ‘hevc’, compatible-brands = ‘mif1’ meta box: (container) handler box: hdlr = ‘hevc’ primary item box: item_ID = 10 Item Information Entries: item_type = ‘hvc1’, itemID=1 (sub-image) item_type = ‘hvc1’, itemID=2 (sub-image) item_type = ‘hvc1’, itemID=3 (sub-image) item_type = ‘hvc1’, itemID=4 (sub-image) item_type=‘simd’ itemID=5 (sub-image 1 descriptor, same isre as in example 2) item_type=‘simd’ itemID=6 (sub-image 2 descriptor, same isre as in example 2) item_type=‘simd’ itemID=7 (sub-image 3 descriptor, same isre as in example 2) item_type=‘simd’ itemID=8 (sub-image 4 descriptor, same isre as in example 2) item_type = ‘hvcC’, item_ID=9 (decoder config, shared among all sub-images) item_type = ‘hvco’, itemID=10 (the composite image) item_type=‘simd’ itemID=11 (full image, isre = {0, 0, 640, 384, 0}) // the referential for composition Item Reference: type=‘simr’ from_item_ID=5, to_item_ID=1 type=‘simr’ from_item_ID=6, to_item_ID=2 type=‘simr’ from_item_ID=7, to_item_ID=3 type=‘simr’ from_item_ID=8, to_item_ID=4 type=‘init’, from_item_ID=9, reference_count=4, to_item_ID=3, 4, 5, 9, 10 (reverse order) type=‘simr’ from_item_ID=11, to_item_ID=10 Item Location: itemID = 1, extent_count = 1, extent_offset = P1, extent_length = L1; itemID = 2, extent_count = 1, extent_offset = P2, extent_length = L2; itemID = 3, extent_count = 1, extent_offset = P3, extent_length = L3; itemID = 4, extent_count = 1, extent_offset = P4, extent_length = L4; itemID = 5, extent_count = 1, extent_offset = P5, extent_length = L5; itemID = 6, extent_count = 1, extent_offset = P6, extent_length = L6; itemID = 7, extent_count = 1, extent_offset = P7, extent_length = L7; itemID = 8, extent_count = 1, extent_offset = P8, extent_length = L8; itemID = 9, extent_count = 1, extent_offset = P0, extent_length = L0; itemID = 10, extent_count = 4, // full composed from 4 sub- images extents P1, P2, P3, P4 Media data box: 1 HEVC Decoder Configuration Record (‘hvcC’ at offset P0) 4 HEVC Images (at file offsets P1, P2, P3, P4) 4 Simple Image Metadata items (at file offsets P5, P6, P7, P8) In another embodiment, the information indicating that the primary item is a composite picture and not an HEVC picture, is preferably indicated it in the handler box or even as a specific brand so that the player immediately gets the information, without starting to parse the different items.", "This description and new item type for composite picture item can also apply to tiles from a same image or from different images.", "Again, depending on the profile, level, tiling configuration in the different images, the composite picture cannot reuse the decoder configuration information from one or another sub-image picture thus requiring its own signalization having a specific type.", "Another kind of picture item type can be useful to indicate that the primary item is a cropped version of an HEVC image.", "This can be signaled for example with the code: ‘hvcr’, for an HEVC Cropped Image either in the image item type or at higher level in the description file like the handler box or through a dedicated brand indicating that various HEVC profiles are in use.", "This can be useful when the resulting cropped image leads to a required decoder profile lower than the required profile to decode the original bigger image.", "The author of the presentation can optionally associate modified decoder configuration information reflecting the cropping operation to the cropped image item.", "For example, cropping from ultra high resolution to HD change the level information.", "With this specific signalization, a player will rapidly determine whether it can handle or not the cropped image item.", "However, when decoder configuration is different for the cropped image, the brand or the type given in the handler should reflect the highest profile and level in use in the file.", "In such case, players aware of hvcr code could check in the image information item whether one image can be displayed even if it does not support the highest profile and/or level in use.", "Finally, according to an embodiment, the invention proposes a creation of a new item type for pictures resulting from a composition of several HEVC sub-images or tiles.", "For example, the new item type may be ‘hvco’ for HEVC Composition image.", "Such image, contrary to ‘hvc1’, does not require to be linked to a specific ‘hvcC’ item.", "Indeed a specific ‘hvcC’ item is not always available given that the sub-image pictures involved may come from different HEVC sub-images.", "In other words, the composite picture or still images may be defined by the fact that they are related to a primary still image and that they have also to be defined, for example using an item like ‘hvco’.", "Optionally, the composite picture item may be linked to an item ‘simd’ identifying the spatial relation of the composite picture and the sub-image pictures and other metadata descriptor.", "So a parser can easily have the display sizes of the composite picture (without having to parse all the ‘simd’ items related to the sub-images involved in the composition).", "Optionally, when composition is done with sub-images sharing the same ‘hvcC’ information, the item for the composite image can also be linked to this same ‘hvcC’ item.", "The link to ‘hvcC’ item is not mandatory for images with ‘hvco’ image items.", "Optionally, a composite picture can be linked to the sub-images through a ‘tile’ or ‘base’ reference image item, ‘tile’ indicating the referenced sub-image pictures are spatial parts of the composite picture and ‘base’ indicating that the composite picture is derived from the referenced sub-image pictures.", "Moreover, to improve readability and compactness of initialization data declarations, image items can be linked to an item of type ‘hvcC’ by an item reference of type ‘init’ from the ‘hvcC’ item to the list of image items using it.", "Items of type ‘hvcC’ may contain the HEVC decoder configuration record defined as structurally identical to the HEVC Decoder Configuration Record in ISO/IEC 14496-15.FIG.", "10 illustrates a multimedia client (typically a multimedia player) processing an encapsulated data file.", "Such a client should implement a parser, for example as a software module in charge of reading and interpreting the Still Image file format parameters.", "During a step 1000 the client parses the multimedia file comprising the encapsulated data file, looking at the encapsulated metadata (typically the meta boxes in the Still Image File Format) describing the media data.", "It checks in 1001 whether a primary item is declared to be displayed as the default image.", "Once the item identifier is retrieved, during step 1002, it is checked whether it is an HEVC image item or a composite HEVC item, by looking at its item type.", "If it is an HEVC image, the client simply gets the initialization data to set up its decoder (1004) and retrieves the corresponding data provided to the HEVC decoder for rendering (1005).", "In case of a composition image, the player checks whether all sub-image pictures are involved or only a subset: first by looking for a ‘base’ or ‘tile’ reference to the composite picture.", "If no reference is found the player collects the sub-image pictures being linked to a spatial relation descriptor (for example following a ‘simr’ reference type).", "Then, the parser checks whether spatial relation information or display parameters are available for the composition picture or not.", "If present, it is read directly from the corresponding metadata item (for example having ‘simd’ item type), otherwise it is computed from the spatial relation descriptors or display parameters of the used sub-image pictures as the maximum value of their display_offsets and display_sizes.", "This is the object of step 1007.The next step is to initialize the decoder.", "Since it is a HEVC composition picture, various types of content for the ‘hvcC’ code have to be considered.", "Depending on whether the player implements one or several HEVC decoders, it sequentially sets up and decodes each sub-image listed in 1005 or process them in parallel (1008).", "Each decoded picture is composed according to its spatial relation descriptor or display parameters (1009).", "Then, the display “screen” (meaning the area where to display the decoded picture) can be set up with display size information.", "If the multimedia client provides an image manipulation tool, it can be used to generate a new composite picture with the available picture items.", "Then, following the steps described with respect to FIG.", "9, client implementing the invention can generate a modified version of the multimedia file including the so-generated composite picture(s).", "FIG.", "11 is a schematic block diagram of a computing device 900 for implementation of one or more embodiments of the invention.", "The computing device 1100 may be a device such as a micro-computer, a workstation or a light portable device.", "The computing device 900 comprises a communication bus connected to: a central processing unit 1101, such as a microprocessor, denoted CPU; a random access memory 1102, denoted RAM, for storing the executable code of the method of embodiments of the invention as well as the registers adapted to record variables and parameters necessary for implementing the method for reading and writing the manifests and/or for encoding the video and/or for reading or generating the Data under a given file format, the memory capacity thereof can be expanded by an optional RAM connected to an expansion port for example; a read only memory 1103, denoted ROM, for storing computer programs for implementing embodiments of the invention; a network interface 1104 is typically connected to a communication network over which digital data to be processed are transmitted or received.", "The network interface 1104 can be a single network interface, or composed of a set of different network interfaces (for instance wired and wireless interfaces, or different kinds of wired or wireless interfaces).", "Data are written to the network interface for transmission or are read from the network interface for reception under the control of the software application running in the CPU 1101; a user interface 1105 for receiving inputs from a user or to display information to a user; a hard disk 1106 denoted HD an I/O module 1107 for receiving/sending data from/to external devices such as a video source or display The executable code may be stored either in read only memory 1103, on the hard disk 906 or on a removable digital medium such as for example a disk.", "According to a variant, the executable code of the programs can be received by means of a communication network, via the network interface 1104, in order to be stored in one of the storage means of the communication device 1100, such as the hard disk 1106, before being executed.", "The central processing unit 1101 is adapted to control and direct the execution of the instructions or portions of software code of the program or programs according to embodiments of the invention, which instructions are stored in one of the aforementioned storage means.", "After powering on, the CPU 1101 is capable of executing instructions from main RAM memory 1102 relating to a software application after those instructions have been loaded from the program ROM 1103 or the hard-disc (HD) 1106 for example.", "Such a software application, when executed by the CPU 1101, causes the steps of a method according to embodiments to be performed.", "Alternatively, the present invention may be implemented in hardware (for example, in the form of an Application Specific Integrated Circuit or ASIC).", "The present invention may be embedded in a device like a camera, a smartphone or a tablet that acts as a remote controller for a TV, for example to zoom in onto a particular region of interest.", "It can also be used from the same devices to have personalized browsing experience of the TV program by selecting specific areas of interest.", "Another usage from these devices by a user is to share with other connected devices some selected sub-parts of his preferred videos.", "It can also be used in smartphone or tablet to monitor what happened in a specific area of a building put under surveillance provided that the surveillance camera supports the generation part of this invention.", "According to a first aspect of the invention there is provided a method of encapsulating an encoded bitstream representing one or more images, the method comprising: providing tile description information comprising spatial parameters for dividing an image area into one or more tiles; providing tile picture item information identifying a portion of the bitstream representing a tile of a single image; providing reference information linking said tile picture item to said tile description information, and outputting said bistream together with said provided information as an encapsulated data file.", "The output may be performed according to a defined standard, and is readable and decodable.", "A method according to the first aspect makes it possible to easily identify, select and extract tiles from, for example, ultra-high resolution images (4K2K, 8K4K .", ".", ".", "), by parsing syntax elements and without complex computation.", "The description tools of the metadata boxes of the ISO Base Media File Format can be extended.", "In particular, it makes it possible to associate tile description with information items.", "Parts of the ‘meta’ boxes hierarchy can be extended so as to provide additional description tools and especially to support tile-based access within still images.", "A method according to the first aspect makes it possible to easily extract, from an encoded HEVC Still Picture, a region of interest based on HEVC tiles.", "Embodiments of the invention provide tile description support and tile access for still images encoded according to the HEVC standard.", "This makes it possible to preserve the region of interest feature available for video tracks for still image.", "In general, parts of a still picture corresponding to a user-defined region of interest can be identified and easily extracted for rendering or transmission to media players.", "For example, said encapsulated encoded bitstream also contains information identifying a timed portion of said data stream corresponding to a video sequence.", "Therefore, double indexing can be provided on a single piece of data that provides the same access facilities to the video as in some still images that are part of this video.", "For example, tile description information includes a set of spatial parameters for each tile picture item.", "For example, tile description information includes spatial parameters common to more than one tile picture item.", "For example, tile description information is embedded in the bitstream.", "For example, tile description information is provided as metadata.", "For example, the reference information includes a reference type, and additional descriptive metadata including said tile description information.", "For example, the reference information includes a reference type, and a reference parameter relating to said tile description information The method may further comprise providing a metadata item for referencing said tile description information in the bitstream.", "For example, tile picture items are grouped and wherein the reference information is provided for linking a group of tile picture items to said tile description information.", "For example, all references linking metadata items to another item are included in a single reference box in the encapsulated data file.", "For example, all the relationships from one item, of any type, are stored in a single item information descriptor.", "For example, wherein said outputting is performed by a server module for adaptive streaming.", "For example, said outputting is performed for storage into a memory.", "For example, said outputting is performed to a display module for display.", "For example, said outputting is performed by a communication module for transmission.", "For example, said encapsulated data file corresponds to a standardized file format.", "For example, said encapsulated data file is decodable and playable.", "According to a second aspect of the invention there is provided a method of processing an encapsulated data file including an encoded bitstream corresponding to one or more images, and information including tile description information comprising spatial parameters for dividing an image area into one or more tiles, the method comprising: selecting an image region of interest, identifying, from said tile description information, tiles which correspond to the selected area of interest, selecting one or more tile picture items linked to said identified tiles, each tile picture item identifying a portion of the bitstream representing a tile of a single image, extracting a portion of the bitstream identified by the selected tile picture item(s), and outputting said extracted bitstream portion.", "For example, wherein said outputting is performed by a server module for adaptive streaming.", "For example, said outputting is performed for storage into a memory.", "For example, said outputting is performed to a display module for display.", "For example, said outputting is performed by a communication module for transmission.", "For example, said encapsulated data file corresponds to a standardized file format.", "For example, said encapsulated data file is decodable and playable.", "According to a third aspect of the invention there is provided a method of processing image data representing at least one image for encapsulation into an encapsulation file, the method comprising: obtaining a spatial subdivision of said at least one image into a plurality of image portions, determining at least one portion identification data identifying a data portion within said image data, representing an image portion of said plurality, encapsulating said image data into said encapsulation file along with at least: subdivision description data representing said subdivision of said at least one image, said portion identification data, and reference data linking said subdivision description data and said portion identification data.", "For example, said image data represent a plurality of images of a video sequence, and the method further comprises determining at least one time identification data identifying a data portion within said image data, representing a time portion of said video sequence, and said image data are encapsulated along with said time identification data.", "For example, a plurality of portion identification data are determined respectively representing a same image portion of the images of said time portion of said video sequence.", "For example, at least said subdivision description data is encapsulated as metadata to the image data.", "For example, said spatial subdivision is embedded in a bitstream containing said image data.", "For example, respective portion identification data are determined for each image portion.", "For example, common portion identification data are determined for a plurality of image portions.", "The method may further comprise outputting said encapsulation file into a bitstream for adaptive streaming by a server device.", "The method may further comprise outputting said encapsulation file into a bitstream for transmission to a display device for displaying said image data.", "The method may further comprise outputting said encapsulation file into a bitstream for transmission to a client device.", "The method may further comprise storing said encapsulation file into a storage device.", "For example, the reference data includes a reference type, and additional descriptive metadata including said subdivision description data.", "For example, the reference data includes a reference type and a reference parameter relating to said subdivision description data.", "For example, said subdivision description data is referenced in a metadata item.", "For example, portion identification data are grouped and wherein the reference data links a group of portion identification data to said portion identification data.", "For example, said encapsulated file comprises a single reference box containing all reference data for the image data.", "For example, said encapsulated file comprises a description containing a representation of the relationships between said subdivision description data, portion identification data and reference data.", "According to a fourth aspect of the invention, there is provided a method of processing an encapsulation file comprising: image data representing at least one image, subdivision description data representing a spatial subdivision of said at least one image into a plurality of image portions, at least one portion identification data identifying a data portion within said image data, representing an image portion of said plurality, and reference data linking said subdivision description data and said portion information, the method comprising: determining a region of interest in said at least one image, determining, based on said subdivision description data, at least one image portion, belonging to said region of interest, accessing, based on said reference data, at least one portion identification data identifying a data portion within said image data, representing said at least one image portion belonging to said region of interest, and extracting said data portion within said image data.", "For example, said image data comprise a plurality of images of a video sequence, and said encapsulation file further comprises at least one time identification data identifying a data portion within said image data, representing a time portion of said video sequence, the region of interest being determined for the images of said time portion of said video sequence and the data portions corresponding to said region of interest in a plurality of images of said time portion of said video sequence are extracted.", "For example, a plurality of portion identification data respectively represent a same image portion of the images of said time portion of said video sequence.", "For example, at least said subdivision description data is encapsulated as metadata to the image data.", "For example, respective portion identification data are determined for each image portion.", "For example, common portion identification data are determined for a plurality of image portions.", "The method may further comprise receiving said encapsulation file as a bitstream adaptively streamed by a server device.", "The method may further comprise displaying said region of interest.", "For example, the reference data includes a reference type, and additional descriptive metadata including said subdivision description data.", "For example, the reference data includes a reference type and a reference parameter relating to said subdivision description data.", "For example, said subdivision description data is referenced in a metadata item.", "For example, portion identification data are grouped and wherein the reference data links a group of portion identification data to said portion identification data.", "For example, said encapsulated file comprises a single reference box containing all reference data for the image data.", "For example, said encapsulated file comprises a description containing a representation of the relationships between said subdivision description data, portion identification data and reference data.", "According to a fifth aspect of the invention, there is provided a device configured to implement a method according to the first aspect.", "The device may comprise: a processing unit configured to provide tile description information comprising spatial parameters for dividing an image area into one or more tiles; provide tile picture item information identifying a portion of the bitstream representing a tile of a single image; provide reference information linking said tile picture item to said tile description information, and a communication unit configured to output said bistream together with said provided information as an encapsulated data file.", "According to a sixth aspect of the invention, there is provided a device configured to implement a method according to the second aspect.", "The device may be configured to process an encapsulated data file including an encoded bitstream corresponding to one or more images, and information including tile description information comprising spatial parameters for dividing an image area into one or more tiles.", "The device may also comprise: a processing unit configured to select an image region of interest, identify, from said tile description information, tiles which correspond to the selected area of interest, select one or more tile picture items linked to said identified tiles, each tile picture item identifying a portion of the bitstream representing a tile of a single image, extract a portion of the bitstream identified by the selected tile picture item(s), and a communication unit configured to output said extracted bitstream portion.", "According to a seventh aspect of the invention, there is provided a device configured to implement a method according to the third aspect.", "The device may be configured to process image data representing at least one image for encapsulation into an encapsulation file, and the device may comprise a processing unit configured to obtain a spatial subdivision of said at least one image into a plurality of image portions, determine at least one portion identification data identifying a data portion within said image data, representing an image portion of said plurality, encapsulate said image data into said encapsulation file along with at least: subdivision description data representing said subdivision of said at least one image, said portion identification data, and reference data linking said subdivision description data and said portion identification data.", "According to an eighth aspect of the invention, there is provided a device configured to implement a method according to the fourth aspect.", "The device may be configured to process an encapsulation file comprising: image data representing at least one image, subdivision description data representing a spatial subdivision of said at least one image into a plurality of image portions, at least one portion identification data identifying a data portion within said image data, representing an image portion of said plurality, and reference data linking said subdivision description data and said portion information.", "The device may also comprise a processing unit configured to determine a region of interest in said at least one image, determine, based on said subdivision description data, at least one image portion, belonging to said region of interest, access, based on said reference data, at least one portion identification data identifying a data portion within said image data, representing said at least one image portion belonging to said region of interest, and extract said data portion within said image data.", "According to a ninth aspect of the invention, there is provided a system comprising: a first device according to the fifth of seventh aspect, and a second device according to the sixth of eighth aspect for processing files from said first device.", "According to a tenth aspect of the invention there are provided computer programs and computer program products comprising instructions for implementing methods according to the first, second, third and/or fourth aspect(s) of the invention, when loaded and executed on computer means of a programmable apparatus.", "According to a eleventh aspect of the invention there are provided a method of encapsulating an encoded bitstream representing one or more images, the method comprising: providing description of images and/or sub-image pictures identifying portions of the bitstream representing said images and/or sub-images of said images; providing description of at least one composite picture formed by one or more images and/or sub-image pictures; and outputting said bitstream together with said provided composite picture description as an encapsulated data file.", "In an embodiment, the provided composite picture description is listed in a metadata box.", "In an embodiment, the provided composite picture description is signaled by a composite picture item.", "In an embodiment, the method further comprises providing reference information linking said composite picture description to said images and/or sub-image pictures forming the composite picture, and further outputting said bitstream together with said provided reference information in the encapsulated data file.", "In an embodiment, the provided reference information includes a reference item.", "In an embodiment, the provided reference information comprises information which indicates if image and/or sub-image pictures forming part of the composite picture are spatial parts or based on images.", "In an embodiment, the method further comprises providing images and/or sub-image description information comprising display parameters relating to one or more image and/or sub-image pictures, said reference information linking said composite picture item to the image and/or sub-image description information.", "In an embodiment, at least two image and/or sub-image pictures forming part of the composite picture identify portions of the bitstream representing two different images and/or sub-images of at least two different images.", "In an embodiment, the method further comprises comparing the configurations of decoding methods used for decoding the at least two different images, and if the configurations are similar, then providing only one configuration item identifying the configuration of a decoding method, for the composite picture, and and further outputting said bitstream together with said provided configuration item in the encapsulated data file.", "According to a twelfth aspect of the invention, there are provided a method of processing an encapsulated data file including an encoded bitstream corresponding to one or more images, and information including a composite picture description for at least one composite picture, a composite picture being formed by images and/or sub-image pictures identifying portions of the bitstream representing images and/or sub-images of images, the method comprising: selecting at least one composite picture; determining the images and/or sub-images forming the composite picture; and displaying said composite picture.", "In an embodiment, the provided composite picture description is listed in a metadata box.", "In an embodiment, the provided composite picture description is signaled by a composite picture item.", "In an embodiment, the encapsulated data file further including reference information linking said composite picture description to said images and/or sub-image pictures forming the composite picture, and further outputting said bitstream together with said provided reference information in the encapsulated data file.", "In an embodiment, the reference information includes a reference item.", "In an embodiment, the reference information comprises information which indicates if image and/or sub-image pictures forming part of the composite picture are spatial parts or based on images.", "In an embodiment, the encapsulated data file further comprising images and/or sub-image description information comprising display parameters relating to one or more image and/or sub-image pictures, said reference information linking said composite picture item to the image and/or sub-image description information.", "In an embodiment, at least two image and/or sub-image pictures forming part of the composite picture identify portions of the bitstream representing two different images and/or sub-images of at least two different images.", "In an embodiment, the encapsulated data file further comprising only one configuration item identifying the configuration of a decoding method for the composite picture.", "In an embodiment, the configuration of the decoding method is the HEVC standard configuration.", "According to a thirteenth aspect of the invention, there are provided a method of encapsulating an encoded bitstream representing one or more images, the method comprising: providing at least one cropped picture representing a portion of an image picture or a sub-image picture identifying portions of the bitstream representing images or sub-images of images; providing cropped picture information identifying the cropped picture; and outputting said bitstream together with said provided cropped picture information as an encapsulated data file.", "According to a fourteenth aspect of the invention, there are provided a method of processing an encapsulated data file including an encoded bitstream corresponding to one or more images, and information including cropped picture information for at least one cropped picture, a cropped picture representing a portion of an image or a sub-image identifying portions of the bitstream representing images or sub-images of images, the method comprising: selecting at least one cropped picture; and displaying said cropped image.", "According to a fifteenth aspect of the invention, there is provided a device configured to implement a method according to the eleventh aspect.", "The device may also comprise: a processing unit configured to provide description of images and/or sub-image pictures identifying portions of the bitstream representing said images and/or sub-images of said images; to provide description of at least one composite picture formed by one or more images and/or sub-image pictures, and a communication unit configured to output said bitstream together with said provided composite picture description as an encapsulated data file.", "According to a sixteenth aspect of the invention, there is provided a device configured to implement a method according to the twelfth aspect.", "The device may also comprise: a processing unit to select at least one composite picture; to determine the images and/or sub-images forming the composite picture; and a display unit configured to display said composite picture.", "According to a seventeenth aspect of the invention, there is provided a device configured to implement a method according to the thirteenth aspect.", "The device may also comprise: a processing unit to provide at least one cropped picture representing a portion of an image picture or a sub-image picture identifying portions of the bitstream representing images or sub-images of images; to provide cropped picture information identifying the cropped picture; and a communication unit to output said bitstream together with said provided cropped picture information as an encapsulated data file.", "According to a eighteenth aspect of the invention, there is provided a device configured to implement a method according to the fourteenth aspect.", "The device may also comprise a processing unit to select at least one cropped picture; and a display unit to display said cropped image.", "According to a nineteenth aspect of the invention, there is provided a system comprising: a first device according to the eleventh or thirteenth aspect, and a second device respectively according to the twelfth or fourteenth aspect for processing files from said first device.", "According to a twentieth aspect of the invention there are provided computer programs and computer program products comprising instructions for implementing methods according to the eleventh, twelfth, thirteenth and/or fourteenth aspect(s) of the invention, when loaded and executed on computer means of a programmable apparatus.", "While the invention has been illustrated and described in detail in the drawings and foregoing description, such illustration and description are to be considered illustrative or exemplary and not restrictive, the invention being not restricted to the disclosed embodiment.", "Other variations to the disclosed embodiment can be understood and effected by those skilled in the art in practicing the claimed invention, from a study of the drawings, the disclosure and the appended claims.", "In the claims, the word “comprising” does not exclude other elements or steps, and the indefinite article “a” or “an” does not exclude a plurality.", "A single processor or other unit may fulfil the functions of several items recited in the claims.", "The mere fact that different features are recited in mutually different dependent claims does not indicate that a combination of these features cannot be advantageously used.", "Any reference signs in the claims should not be construed as limiting the scope of the invention." ] ]
Patent_15872867
[ [ "Curved Array of Light-Emitting Elements for Sweeping out an Angular Range", "The present disclosure relates to curved arrays of individually addressable light-emitting elements for sweeping out angular ranges.", "One example device includes a curved optical element.", "The device may also include a curved array of individually addressable light-emitting elements arranged to emit light towards the curved optical element.", "A curvature of the curved array is substantially concentric to at least a portion of the circumference of the curved optical element.", "The curved optical element is arranged to focus light emitted from each individually addressable light-emitting element to produce a substantially linear illumination pattern at a different corresponding scan angle within an angular range.", "The device may further include a control system operable to sequentially activate the individually addressable light-emitting elements such that the substantially linear illumination pattern sweeps out the angular range." ], [ "1.A device comprising: a curved optical element; a curved array of individually addressable light emitters arranged to emit light towards the curved optical element, wherein a curvature of the curved array is greater than or less than a curvature of a perimeter of the curved optical element, wherein the curved optical element is arranged to focus light emitted from each individually addressable light emitter to produce a substantially linear illumination pattern at a different corresponding scan angle within an angular range; a controller operable to sequentially activate the individually addressable light emitters such that the substantially linear illumination pattern sweeps out the angular range; a light detector configured to detect the substantially linear illumination pattern; and a computer configured to determine an angular position of the light detector based upon the pattern sweep.", "2.The device of claim 1, wherein the substantially linear illumination pattern sweeping out the angular range is used to scan a physical space horizontally.", "3.The device of claim 1, wherein the substantially linear illumination pattern sweeping out the angular range is used to scan a physical space vertically.", "4.The device of claim 1, wherein the curved array is fabricated on a curved printed circuit board.", "5.The device of claim 1, wherein the curved array contains thirty-two individually addressable light emitters.", "6.The device of claim 1, wherein the number of individually addressable light emitters in the curved array contributes to an angular resolution of the angular range.", "7.The device of claim 1, wherein the number of individually addressable light emitters in the curved array contributes to the size of the angular range.", "8.The device of claim 1, wherein the width of the substantially linear illumination pattern focused from one of the individually addressable light emitters is such that the substantially linear illumination pattern would at least partially overlap the substantially linear illumination pattern focused from an adjacent individually addressable light emitter.", "9.The device of claim 1, wherein the angular range is ninety degrees, one hundred and thirty-five degrees, or one hundred and eighty degrees.", "10.The device of claim 1, wherein the curved optical element is a cylindrical lens.", "11.The device of claim 1, wherein all of the individually addressable light emitters in the curved array are disposed at a constant distance from the curved optical element.", "12.The device of claim 1, wherein the individually addressable light emitters are staggered with respect to one another in the curved array such that the substantially linear illumination pattern sweeps out the angular range contiguously.", "13.A method comprising: emitting light from a first individually addressable light emitter toward a curved optical element; focusing, by the curved optical element, the light emitted from the first individually addressable light emitter to produce a substantially linear illumination pattern at a first corresponding scan angle within an angular range; emitting light from a second individually addressable light emitter toward the curved optical element; focusing, by the curved optical element, the light emitted from the second individually addressable light emitter to reproduce the substantially linear illumination pattern at a second corresponding scan angle within the angular range, wherein the first and second individually addressable light emitters are in a curved array of individually addressable light emitters, wherein a curvature of the curved array is greater than or less than a curvature of a perimeter of the curved optical element, and wherein the first and second individually addressable light emitters are sequentially activated by a controller such that the substantially linear illumination pattern sweeps out at least a portion of the angular range; detecting, by a light detector, the light emitted from the first individually addressable light emitter; and determining, by a computer, an angular position of the light detector based upon the pattern sweep.", "14.The method of claim 13, wherein determining the angular position of the light detector comprises associating the detected light emitted from the first individually addressable light emitter with a detection time.", "15.The method of claim 14, further comprising: emitting, simultaneously, light from both the first and the second individually addressable light emitters to generate a synchronization illumination; focusing, by the curved optical element, the light emitted from both the first and the second individually addressable light emitters; detecting, by the light detector, the synchronization illumination; associating the detected synchronization illumination with a synchronization time; and comparing, by a computing device, the detection time with the synchronization time to determine an angular position of the light detector.", "16.The method of claim 13, further comprising: emitting, simultaneously, light from both the first and the second individually addressable light emitters to generate a synchronization illumination; and focusing, by the curved optical element, the light emitted from both the first and the second individually addressable light emitters.", "17.The method of claim 13, further comprising modulating, by the controller, a time interval between emitting light from the first individually addressable light emitter and emitting light from the second individually addressable light emitter.", "18.The method of claim 13, wherein the light emitted from the first individually addressable light emitter and the light emitted from the second individually addressable light emitter are of different wavelengths.", "19.The method of claim 13, wherein the first and the second individually addressable light emitters are light emitting diodes (LEDs).", "20.A system comprising: a light-emitting device, wherein the light-emitting device comprises: a curved optical element; a curved array of individually addressable light emitters arranged to emit light towards the curved optical element, wherein a curvature of the curved array is greater than or less than a curvature of a perimeter of the curved optical element, wherein the curved optical element is arranged to focus light emitted from each individually addressable light emitter to produce a substantially linear illumination pattern at a different corresponding scan angle within an angular range; and a controller operable to sequentially activate the individually addressable light emitters such that the substantially linear illumination pattern sweeps out the angular range; a light detector configured to detect the substantially linear illumination pattern; and a computer configured to determine an angular position of the light detector based upon the pattern sweep." ], [ "<SOH> BACKGROUND <EOH>A variety of techniques exist to map the geometry of an environment and objects within the environment and/or to determine the location of objects of interest within the environment.", "These methods can include applying one or more patterns of illumination to the environment (e.g., an array of vertical and/or horizontal lines of illumination) and imaging the environment, using one or more cameras, when exposed to such illumination.", "Additionally or alternatively, a particular object within the environment could include a tag configured to detect the emitted illumination.", "The location of the tag could be determined based on the detected illumination.", "In a further example, a particular object within the environment could include a tag configured to emit illumination and/or to reflect illumination.", "The location of the tag could be determined by imaging the environment with one or more cameras." ], [ "<SOH> SUMMARY <EOH>The specification and drawings disclose embodiments that relate to a curved array of light-emitting elements for sweeping out an angular range.", "An object within the angular range, equipped with a light detecting device, could identify its location relative to the array of light-emitting elements based on a time associated with a detected illumination.", "In one aspect the disclosure describes a device.", "The device includes a curved optical element.", "The device also includes a curved array of individually addressable light-emitting elements arranged to emit light towards the curved optical element.", "The curvature of the curved array is substantially concentric to at least a portion of the circumference of the curved optical element.", "The curved optical element is arranged to focus light emitted from each individually addressable light-emitting element to produce substantially linear illumination pattern at a different corresponding scan angle within an angular range.", "The device further includes a control system operable to sequentially activate the individually addressable light-emitting elements such that the substantially linear illumination pattern sweeps out the angular range.", "In another aspect the disclosure describes a method.", "The method includes emitting light from a first individually addressable light-emitting element toward a curved optical element.", "The method also includes focusing, by the curved optical element, the light emitted from the first individually addressable light-emitting element to produce a substantially linear illumination pattern at a first corresponding scan angle within an angular range.", "The method further includes emitting light from a second individually addressable light-emitting element toward the curved optical element.", "Additionally, the method includes focusing, by the curved optical element, the light emitted from the second individually addressable light-emitting element to reproduce the substantially linear illumination pattern at a second corresponding scan angle within the angular range.", "The first and second individually addressable light-emitting elements are in a curved array of individually addressable light-emitting elements.", "The first and second individually addressable light-emitting elements are sequentially activated by a control system such that the substantially linear illumination pattern sweeps out at least a portion of the angular range.", "In a third aspect the disclosure describes a system.", "The system includes a light-emitting device.", "The light-emitting device includes a curved optical element.", "The light-emitting device also includes a curved array of individually addressable light-emitting elements arranged to emit light towards the curved optical element.", "A curvature of the curved array is substantially concentric to at least a portion of the circumference of the curved optical element.", "The curved optical element is arranged to focus light emitted from each individually addressable light-emitting element to produce a substantially linear illumination pattern at a different corresponding scan angle within an angular range.", "The light-emitting device further includes a control system operable to sequentially activate the individually addressable light-emitting elements such that the substantially linear illumination pattern sweeps out the angular range.", "In addition, the system includes a light detector.", "The light detector is configured to detect light emitter from the light-emitting device.", "These as well as other aspects, advantages, and alternatives, will become apparent to those of ordinary skill in the art by reading the following detailed description, with reference where appropriate to the accompanying drawings." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS The present application is a non-provisional patent application claiming priority to U.S. patent application Ser.", "No.", "15/181,370, filed Jun.", "13, 2016, and entitled “Curved Array of Light-Emitting Elements for Sweeping out an Angular Range,” the contents of which are hereby incorporated by reference.", "BACKGROUND A variety of techniques exist to map the geometry of an environment and objects within the environment and/or to determine the location of objects of interest within the environment.", "These methods can include applying one or more patterns of illumination to the environment (e.g., an array of vertical and/or horizontal lines of illumination) and imaging the environment, using one or more cameras, when exposed to such illumination.", "Additionally or alternatively, a particular object within the environment could include a tag configured to detect the emitted illumination.", "The location of the tag could be determined based on the detected illumination.", "In a further example, a particular object within the environment could include a tag configured to emit illumination and/or to reflect illumination.", "The location of the tag could be determined by imaging the environment with one or more cameras.", "SUMMARY The specification and drawings disclose embodiments that relate to a curved array of light-emitting elements for sweeping out an angular range.", "An object within the angular range, equipped with a light detecting device, could identify its location relative to the array of light-emitting elements based on a time associated with a detected illumination.", "In one aspect the disclosure describes a device.", "The device includes a curved optical element.", "The device also includes a curved array of individually addressable light-emitting elements arranged to emit light towards the curved optical element.", "The curvature of the curved array is substantially concentric to at least a portion of the circumference of the curved optical element.", "The curved optical element is arranged to focus light emitted from each individually addressable light-emitting element to produce substantially linear illumination pattern at a different corresponding scan angle within an angular range.", "The device further includes a control system operable to sequentially activate the individually addressable light-emitting elements such that the substantially linear illumination pattern sweeps out the angular range.", "In another aspect the disclosure describes a method.", "The method includes emitting light from a first individually addressable light-emitting element toward a curved optical element.", "The method also includes focusing, by the curved optical element, the light emitted from the first individually addressable light-emitting element to produce a substantially linear illumination pattern at a first corresponding scan angle within an angular range.", "The method further includes emitting light from a second individually addressable light-emitting element toward the curved optical element.", "Additionally, the method includes focusing, by the curved optical element, the light emitted from the second individually addressable light-emitting element to reproduce the substantially linear illumination pattern at a second corresponding scan angle within the angular range.", "The first and second individually addressable light-emitting elements are in a curved array of individually addressable light-emitting elements.", "The first and second individually addressable light-emitting elements are sequentially activated by a control system such that the substantially linear illumination pattern sweeps out at least a portion of the angular range.", "In a third aspect the disclosure describes a system.", "The system includes a light-emitting device.", "The light-emitting device includes a curved optical element.", "The light-emitting device also includes a curved array of individually addressable light-emitting elements arranged to emit light towards the curved optical element.", "A curvature of the curved array is substantially concentric to at least a portion of the circumference of the curved optical element.", "The curved optical element is arranged to focus light emitted from each individually addressable light-emitting element to produce a substantially linear illumination pattern at a different corresponding scan angle within an angular range.", "The light-emitting device further includes a control system operable to sequentially activate the individually addressable light-emitting elements such that the substantially linear illumination pattern sweeps out the angular range.", "In addition, the system includes a light detector.", "The light detector is configured to detect light emitter from the light-emitting device.", "These as well as other aspects, advantages, and alternatives, will become apparent to those of ordinary skill in the art by reading the following detailed description, with reference where appropriate to the accompanying drawings.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a perspective view of a curved array of individually addressable light-emitting elements and a curved optical element, according to example embodiments.", "FIG.", "2 is a top view of a curved array of individually addressable light-emitting elements and a curved optical element, according to example embodiments.", "FIG.", "3 is a perspective view of a curved array of individually addressable light-emitting elements projecting into an environment, according to example embodiments.", "FIG.", "4 is a perspective view of a curved array of individually addressable light-emitting elements projecting at a light detector, according to example embodiments.", "FIG.", "5 is a block diagram of an example system that includes a light emitter and an object.", "FIG.", "6a is a top view of light from a curved array of individually addressable light-emitting elements being focused by a curved optical element, according to example embodiments.", "FIG.", "6b is a side view of light from a curved array of individually addressable light-emitting elements being focused by a curved optical element, according to example embodiments.", "FIG.", "7 is a block diagram of a horizontal and vertical projector, according to example embodiments.", "FIG.", "8 is a flowchart of a method, according to example embodiments.", "FIG.", "9 is a flowchart of a method, according to example embodiments.", "DETAILED DESCRIPTION In the following detailed description, reference is made to the accompanying figures, which form a part hereof.", "The illustrative embodiments described in the detailed description, figures, and claims are not meant to be limiting.", "Other embodiments may be utilized, and other changes may be made, without departing from the scope of the subject matter presented herein.", "It will be readily understood that the aspects of the present disclosure, as generally described herein, and illustrated in the figures, can be arranged, substituted, combined, separated, and designed in a wide variety of different configurations, all of which are contemplated herein.", "I. Overview The location of objects in an environment can be determined by illuminating the environment with a plurality of different patterns of illumination over time.", "The patterns of illumination could be specified such that different regions within the environment are exposed to different time-varying waveforms of light intensity.", "Time-varying waveforms of light intensity are illumination patterns (e.g., a substantially linear illumination pattern) that are modulated in time (e.g., by a light emitter).", "The location of an object in the environment could then be determined by detecting a time-varying waveform of light intensity received at one or more locations on the object and associating such detected waveforms with respective regions within the environment.", "For example, a light sensor disposed on an object of interest could detect a time-varying waveform of light intensity incident on the object and the location of the object (e.g., a location or angle of the object relative to one or more light emitters that are emitting different patterns of illumination over time) could then be determined based on the detected time-varying waveform of light intensity.", "Such a light emitter could emit different patterns of illumination that vary across a first range of angles in a first direction relative to the light emitter.", "The emitted patterns of illumination could serve to encode different regions of an environment with respect to the angle relative to the light emitter.", "For example, the light emitter could include an array of a plurality (e.g., thirty-two) of arranged, individually addressable light-emitting elements (e.g., light emitting diodes—LEDs or vertical-cavity surface-emitting lasers—VCSELs) and a curved optical element (e.g., a cylindrical lens).", "The curved optical element may focus light emitted by one of the individually addressable light-emitting elements to produce a substantially linear illumination pattern.", "Further, the substantially linear illumination pattern focused from each individually addressable light-emitting element could be projected at a different corresponding angle, or corresponding range of angles, within a first angular range.", "The individually addressable light-emitting elements may thus be sequentially activated (e.g., by a control system) to sweep out the first angular range.", "The number of individually addressable light-emitting elements within the array could contribute to the width and/or resolution of the first angular range, for example.", "A tag or other device in the environment could detect the light received at a particular point in the environment over time and a time-varying waveform of such detected illumination could be used to determine the angle of the tag relative to the light emitter.", "Such information could be used to determine the location, in one dimension or direction, of the tag relative to the light emitter and/or relative to the environment illuminated by the light emitter.", "For example, the tag or other device that detects the light received from the light emitter could be configured to detect a synchronization pulse from the light emitter.", "The synchronization pulse may be provided by illuminating all of the individually addressable light-emitting elements simultaneously, thereby illuminating the entire area within the first angular range.", "The tag could then detect when the substantially linear illumination pattern that corresponds to the angular position of the tag illuminates the tag (e.g., as the light emitter sequentially illuminates the environment with substantially linear illumination patterns).", "The time interval between the synchronization pulse and the corresponding substantially linear illumination pattern could be used by the tag to determine the relative angular position of the tag.", "As an alternative, the individually addressable light-emitting elements could be activated sequentially to sweep out the angular range in a dual-scan fashion (e.g., the angular range is swept out from 0 to 90 degrees and from 90 to 0 degrees over the same time interval).", "Based on a modulation of the light emitted from the individually addressable light-emitting elements (e.g., the individually addressable light-emitting elements are activated at a rate of 400 kHz for the increasing illumination angles and are activated at a rate of 700 kHz for the decreasing illumination angles), and the relative time interval between the two corresponding substantially linear illumination patterns, as measured by the tag, the first angular position relative to the light emitter can be determined by the tag.", "Additionally, as the individually addressable light-emitting elements may produce Gaussian or Semi-Gaussian illumination profiles for the substantially linear illumination patterns, the width of such a profile, which could indicate the divergence of the illumination pattern, could be used by the tag to determine the distance of the tag from the light emitter.", "The light emitter could further include an additional curved optical element and an additional corresponding array of individually addressable light-emitting elements.", "These additional elements could be disposed such that the substantially linear illumination pattern produced by the additional astigmatic optical element and the additional corresponding array of individually addressable light-emitting elements is substantially orthogonal to the first array of optical elements (e.g., such that the second array sweeps in a second direction that is rotated from the first direction by between 80 degrees and 100 degrees).", "These additional elements could thus sweep out a second angular range that is substantially orthogonal to the first angular range (e.g., the first angular range varies from left to right and the second angular range varies from top to bottom with respect to the environment).", "Similarly, a tag or other device in the environment could detect the light received from the additional array and astigmatic optical element of the light emitter at a particular point in the environment over time.", "The corresponding time-varying waveform of such detected illumination could be used to determine the angle, relative to the light emitter in the second direction, of the tag.", "Such information could be used to determine the angular position, in a second dimension or direction, of the tag relative to the light emitter and/or relative to the environment illuminated by the light emitter.", "The curved optical element could include an aspheric cylindrical lens or other optical component(s).", "The curved optical element may be positioned relative to the array of individually addressable light-emitting elements such that the location of a particular individually addressable light-emitting element corresponds to a specific angle, or set of angles, within the angular range relative to the light emitter.", "Alternatively, one or more of the patterns of illumination emitted from the light emitter (e.g., substantially linear illumination patterns) may correspond to a plurality of individually addressable light-emitting elements within the array.", "The light emitter may be more energy efficient than other light emitter designs by only generating light that is used to illuminate an environment of interest.", "For example, such a light emitter design does not generate and discard light for non-illuminated regions of the environment (e.g., by discarding light to a light dump using a micromirror device).", "Further, such a light emitter may be relatively small, as it does not require masks, light dumps, or other elements beyond the array and curved optical element.", "The individually addressable light-emitting elements within the array may be operated by applying current via interconnects (e.g., on a circuit board) to generate respective different patterns of illumination from such a light emitter.", "Multiple such light emitters may be provided, e.g., to provide different patterns of illumination over time such that the angle and/or location of a tag or other light-sensitive device in an environment may be determined with respect to two or more angles and/or directions.", "For example, one light emitter could provide one type of illumination pattern from a particular location that encodes regions of an environment in one direction.", "Then, another light emitter could provide a different type of illumination pattern from the same location that encodes regions of the environment in another orthogonal direction.", "A light detector within the environment could detect time-varying waveforms of light received from the first and second light emitters and use such detected waveforms of light to determine the angle of the light detector relative to the light emitter.", "Additionally or alternatively, multiple light emitters could be located at two or more different locations.", "The location of a light detector in an environment, relative to the two or more different locations, could be determined from time-varying waveforms of light emitted by the light emitters when detected by the light detector (e.g., using triangulation).", "A light detector receiving time-varying waveforms of illumination from two or more light emitters could include the light emitters emitting illumination during respective different, non-overlapping periods of time (e.g., using a method of time division multiplexing), the light emitters emitting light having different wavelengths (e.g., using a method of wavelength multiplexing), the light emitters emitting light at different carrier frequency rates, or the light emitters emitting light that is distinguishable, by a light detector, by some other method.", "The array of individually addressable light-emitting elements could be curved.", "Further, the curved array could be disposed concentrically about a portion of the curved optical element.", "In this way, the distance between each of the individually addressable light-emitting elements and the curved optical element could remain constant.", "When compared with alternative light emitter designs, the design that incorporates a curved, concentric array of individually addressable light-emitting elements may remove focusing errors (e.g., vignetting) and allow the effective length of the array, and correspondingly the field of view, to be increased.", "The curved array of individually addressable light-emitting elements could be assembled on the surface a flexible printed circuit board (PCB) sheet, for example.", "Alternatively, multiple linear arrays of individually addressable light-emitting elements could be placed around the curved optical element and linked via direct soldering or indirect wiring to form a two-dimensionally curved array.", "It should be understood that the above embodiments, and other embodiments described herein, are provided for explanatory purposes, and are not intended to be limiting.", "II.", "Example Light Emitters and Light Emitting Systems It can be beneficial in a variety of applications to detect and/or determine the location of an object in an environment.", "These applications can include tracking the location of a drone, a ball used in a game, a conductor's baton, a controller, a body part of a person (e.g., for motion capture or gesture recognition), or some object(s).", "In an example application, the location of a plurality of markers or tags disposed on respective different locations on a person's body could be determined and used to detect the location and/or motions of the person and/or of particular parts of the person's body.", "In another example application, the location of a control wand or other device, relative to a head-mounted device or other device worn by a person, could be detected and used as an input to the head-mounted device or other system.", "In yet another example application, the location of a drone, robot, or other mobile system within an environment of interest (e.g., a room of a house, a warehouse, or a factory) could be determined and used to control the motion of the drone, robot, or other mobile system within the environment.", "Determining the location of an object in an environment can include determining an absolute location of the object (e.g., relative to a defined coordinate system within the environment) and/or determining the location of the object relative to one or more other objects (e.g., relative to another object whose absolute or relative location is being determined, relative to a camera used to generate data used to determine the location of the object, relative to a light emitter used to illuminate the object).", "Determining the location of an object could include determining a location (e.g., a displacement) of the object and/or determining an angle of the object relative to a defined coordinate system within the environment.", "The angle of the object could also be determined relative to the location and/or orientation of some other object or device in the environment (e.g., relative to a camera, relative to a light emitter, relative to a person and/or a person's gaze direction).", "The location of an object within an environment could be determined via a variety of methods.", "In some examples, the location of the object could be determined by illuminating the object (e.g., with illumination having a pattern of light that is specified over time and/or space) and/or receiving light from the object (e.g., imaging the environment that includes the object using a camera).", "The object could include a tag that is configured to emit light (e.g., a tag that is configured to emit a time-coded pattern of light to identify the tag) and/or to reflect light from a light emitter to a light detector (e.g., a tag that includes retroreflective material) to facilitate optical determination of the location of the object.", "Additionally or alternatively, the object could include a tag that is configured to detect light received by the object.", "A pattern over time of the intensity of such detected light, or some other property of the detected light, could be used to determine the location of the object.", "Such an arrangement may include one or more light emitters illuminating the environment with patterns of illumination that are specified over time and/or space such that different regions of the environment are illuminated by different patterns of illumination over time.", "Thus, the pattern of illumination detected over time by a light detector on an object could be used to determine the region of the environment within which the object is located.", "Producing such patterns of illumination could include scanning one or more shaped beams of light across the environment, providing a plurality of different patterns of light to the environment over time, or providing illumination to an environment in some other way.", "The provided illumination could vary according to an angle relative to a light emitter (e.g., an angle in one or more directions relative to the light emitter) such that a detected intensity of the illumination over time could be used to determine the angle of a light detector (in one or more directions) relative to the light emitter.", "In a particular example, a light emitter could be configured to provide a plurality of substantially linear illumination patterns during respective different periods of time.", "Each of the substantially linear illumination patterns could provide light to the environment at a corresponding angle, or corresponding set of angles, across a first range of angles in a first direction.", "Thus, as the different substantially linear illumination patterns are produced by the light emitter over time, different regions of the environment can receive respective different time-varying patterns of intensity of the emitted illumination.", "As each of the substantially linear illumination patterns varies with respect to angle in the first direction within the first range of angles, the time-varying patterns of illumination intensity received by a particular region of the environment, which is located within the first ranges of angles in the first direction relative to the light emitter, can be used to determine the angle of the particular region, in the first direction, relative to the light emitter.", "FIG.", "1 is a perspective view of a curved array of individually addressable light-emitting elements 114 and a curved optical element, according to example embodiments.", "The individually addressable light-emitting elements 114 may be arranged on a circuit board 110, for example.", "The curved optical element may be a cylindrical lens 102 that refracts light emitted by the individually addressable light-emitting elements 114, in certain embodiments.", "Together, the cylindrical lens 102 and the curved array of individually addressable light-emitting elements 114 on the circuit board 110 comprise a light emitter 100.The light emitter 100 could be configured and/or operated in a variety of ways to produce, during respective periods of time, patterns of illumination as described herein.", "In a particular example, the individually addressable light-emitting elements 114 could be disposed on the circuit board 110 in a curved array formation (as depicted in FIG.", "1).", "The circuit board 110 may then be disposed relative to the cylindrical lens 102 such that, when a particular individually addressable light-emitting element 114, or a set of individually addressable light-emitting elements 114, is operated to emit light, the light emitter produces a respective pattern of illumination as described herein (e.g., a substantially linear illumination pattern).", "The location, on the circuit board 110 relative to the cylindrical lens 102, of the individually addressable light-emitting elements 114 of a particular set of individually addressable light-emitting elements 114 could be specified to control the pattern of illumination emitted by the particular set of individually addressable light-emitting elements 114.The duration of the periods of time during which the light emitter 100 produces each substantially linear illumination pattern, and the rate at which a sequence of such different substantially linear illumination patterns is repeated, could be specified to facilitate the determination of the angular position of a light detector or other object at more than a specified rate.", "For example, a sequence of substantially linear illumination patterns from the light emitter 100 could be repeated at a rate greater than 10 Hertz.", "Further, if six or more different substantially linear illumination patterns were produced during each repetition of such a sequence (e.g., to provide six different illuminated environmental locations for the determination of the angular position of the light detector or other object in the first direction relative to the light emitter) by six different individually addressable light-emitting elements, each pattern of illumination could be provided during respective time periods that are less than 16.7 milliseconds in duration.", "The illustrated light emitter 100 for producing substantially linear illumination patterns can have a number of benefits relative to other apparatuses for generating such patterns of illumination.", "The energy efficiency of generating patterns of illumination using a light emitter as described herein can be greater than other methods of generating such patterns of illumination (e.g., by absorbing or otherwise blocking a portion of an emitting light using a mask, by reflecting, by a digital micromirror device, a specified portion of light produced by a light source to be absorbed by a light sink or other element).", "Further, by forming the individually addressable light-emitting elements 114 on the circuit board 110, an alignment between different sets of the individually addressable light-emitting elements 114 can be precisely controlled.", "This could allow for increased alignment between features (e.g., ranges of angles) of different produced patterns of illumination (e.g., substantially linear illumination patterns) that correspond to the respective different sets of individually addressable light-emitting elements 114.Still further, incorporating the individually addressable light-emitting elements into a single die that is adhered to or otherwise disposed relative to a curved optical element can provide a light-emitting device that has a small size relative, for example, to other light-emitting apparatuses that include multiple masks, light-emitting elements, or other optical elements, or other means for producing patterns of illumination as described herein.", "By connecting the individually addressable light-emitting elements 114, via electrical interconnects for example, into a number of sets of individually addressable light-emitting elements 114 that correspond to respective emitted patterns of illumination, the different patterns of illumination can be produced without the use of electronic switches (e.g., transistors) being present on the circuit board 110.Additionally, by disposing the individually addressable light-emitting elements 114 about the cylindrical lens 102 in a curved array, vignetting errors can be reduced or eliminated and the field of view can be increased as the individually addressable light-emitting elements 114 can concentrically surround as much as 180 degrees of the cylindrical lens 102, for example.", "Additional advantages of the apparatuses for generating patterns of illumination described herein will be apparent.", "The illustrated locations and sizes of the individually addressable light-emitting elements 114 on the circuit board 110, the curvature and extent of the circuit board 110, and other details of the light emitter 100 illustrated in FIG.", "1 are intended as non-limiting, illustrative embodiments of the methods and apparatus described herein.", "Different locations of individually addressable light-emitting elements on a circuit board, corresponding to different patterns of emitted illumination, are anticipated by the inventors.", "Further, different interconnections of sets of individually addressable light-emitting elements may be used.", "For example, first and second sets of individually addressable light-emitting elements could be connected, with opposite polarities, to first and second electrical pads of a circuit board.", "This may allow a selected one of the first and second sets of individually addressable light-emitting elements to be operated to emit light by controlling a polarity of voltage provided to the sets of individually addressable light-emitting elements via the first and second electrical pads.", "The number of electrical pads on the circuit board used to provide current and/or voltage to sets of individually addressable light-emitting elements of the circuit board could be reduced by using an electrical pad in common between a number of sets of individually addressable light-emitting elements and/or pairs of sets of individually addressable light-emitting elements.", "Other configurations of interconnections between individually addressable light-emitting elements and electrical pads of a circuit board may be used.", "The circuit board 110 may comprise a die (e.g., a die composed of gallium arsenide, silicon, and/or other semiconductor materials), on which or in which other components of the light emitter 100 are formed.", "In some embodiments, the circuit board 110 is a printed circuit board (PCB).", "Such a circuit board may have a FR-4 glass epoxy substrate with copper conductive layers, in some embodiments.", "The copper conductive layers could be etched or deposited, in various embodiments, to define electrical interconnects, for example.", "Furthermore, the electrical interconnects may be connected to electrical pads on the circuit board such that each of the sets of individually addressable light-emitting elements can be operated by providing current and/or voltage to corresponding electrical pads on the circuit board.", "In alternate embodiments, the circuit board 110 may be replaced with a flexible material.", "For example, organic LEDs may be formed in an organic semiconductor substrate to define the individually addressable light-emitting elements 114.Still further, in some alternate embodiments, the individually addressable light-emitting elements 114 may be attached (e.g., physically and/or electrically) to one another to define an array.", "This may obviate the need to include a structure on which the individually addressable light-emitting elements are arranged (e.g., the circuit board 110).", "The individually addressable light-emitting elements 114 could include LEDs, VCSELs, lasers, or other individually addressable light-emitting components formed on or of the circuit board 110.For example, if the circuit board 110 were a semiconductor material, the individually addressable light-emitting elements 114 could include light-emitting diode regions, light-emitting quantum wells, Bragg reflectors, or other elements formed from gallium arsenide, aluminum gallium arsenide, positive or negative doping materials, or other materials or structures.", "Forming the individually addressable light-emitting elements 114 could include photopatterning, photolithography, chemical vapor deposition, sputtering, oxidation, ion implantation, or other methods for forming elements of an integrated optoelectronic circuit.", "The individually addressable light-emitting elements 114 may be packaged in such a way that a portion of the individually addressable light-emitting elements 114 does not emit light.", "This could be because the packaging occludes some of the light-emitting area.", "Alternatively, there may be electrical components integrated within each individually addressable light-emitting elements 114, which prevent the entire individually addressable light-emitting element 114 from being capable of emitting light.", "The effective portion of the individually addressable light-emitting element 114 may be referred to as the projecting surface, in some embodiments.", "The curved optical element of a light emitter, as described herein, could be configured in a variety of ways, and include a variety of elements (e.g., lenses, mirrors, diffraction gratings, and/or prisms) such that light emitted from a set of individually addressable light-emitting elements of the light emitter is projected as a pattern of illumination that varies with angle across a first range of angles in a first direction (e.g., that provides illumination within one or more ranges of angles within the first range of angles).", "This could include focusing and/or deflecting light emitted by the individually addressable light-emitting elements, with respect to the first direction, such that the location of a particular individually addressable light-emitting element is related to a range of angles of the environment.", "This could further include defocusing and/or spreading light from the individually addressable light-emitting element with respect to a second direction.", "As such, the curved optical element could also be an astigmatic optical element.", "The array of individually addressable light-emitting elements could be curved around a portion of the cylindrical lens (as illustrated in FIG.", "1).", "Such a curved array could be concentric to the cylindrical lens.", "Alternatively, the curvature of the curved array could be greater than or less than the curvature of the perimeter of the cylindrical lens.", "In some embodiments, the curved array could be attached to or fabricated on a section of the cylindrical lens, itself.", "The curved array may contain multiple rows and/or columns of individually addressable light-emitting elements that are configured to cooperatively produce one or more substantially linear illumination patterns by projecting light through the cylindrical lens.", "In some embodiments, the individually addressable light-emitting elements, themselves, could be flexible.", "In other embodiments, the individually addressable light-emitting elements could be rigid, but mounted on a flexible surface (e.g., a flexible PCB), allowing the array to be curved about the cylindrical lens.", "Further, the individually addressable light-emitting elements of an interconnected set of one or more individually addressable light-emitting elements could be arranged in some other manner across the surface of a circuit board of a light emitter.", "For example, the individually addressable light-emitting elements could be distributed across the circuit board in order to increase an amount of light emitted from the light emitter and/or reduce a temperature of the array of individually addressable light-emitting elements when the array is operated to sequentially project substantially linear illumination patterns.", "Because the individually addressable light-emitting elements may be distributed across a wider area, there could be more surface area for heat dissipation, which could thereby reduce the overall temperature of the array of individually addressable light-emitting elements.", "The distribution of individually addressable light-emitting elements across a circuit board in a light emitter could be provided in order to reduce an average and/or peak temperature of the light emitter when the individually addressable light-emitting elements are being operated to emit light.", "This could be done by spreading the production of such waste heat over a wider area of the circuit board or according to some other consideration (e.g., to simplify routing of electrical interconnects and/or electrical pads on the circuit board, to provide a configuration of individually addressable light-emitting elements, electrical interconnects, or other features that is compatible with circuit board fabrication process, or to increase the amount of light output from the light emitter).", "As shown in FIGS.", "1-4, the curved optical element could be a single refractive aspheric cylindrical lens 102.However, a curved optical element of a light emitter, as described herein, could include additional or alternative elements configured to focus, deflect, or otherwise modify light emitted from the individually addressable light-emitting elements of the light emitter.", "In an example embodiment, the astigmatic optical element focuses light produced by sets of one or more of the individually addressable light-emitting elements to produce illumination patterns such as those described herein.", "To do so, such a curved optical element could include a diffraction grating, a hologram, or some other reflective, refractive, and/or absorptive elements.", "The curved optical element could include a reflective element having an aspheric optical surface.", "The curved optical element could include a single lens, mirror, grating, or other optical element.", "Alternatively, the curved optical element could include multiple optical components (e.g., multiple lenses, multiple gratings, and/or multiple mirrors).", "In some examples, the curved optical element could include a single refractive or reflective lens having a first surface having a geometry specified to focus and/or deflect the emitted light in a first direction (e.g., a cylindrical geometry, such as an aspheric cylindrical geometry).", "Such a refractive or reflective lens could include a second surface having a geometry specified to defocus and/or spread the emitted light in a second direction that is substantially orthogonal to the first direction (e.g., a concave geometry) such that each individually addressable light-emitting element, when operated to emit light, provides light across a similar range of angles in the second direction.", "Such a curved optical element could therefore focus the light emitted from each individually addressable light-emitting element into a substantially linear illumination pattern, for example.", "Components or features of the curved optical element could be formed on a circuit board, for example, using optically transparent materials, or other elements on the surface of the circuit board (e.g., using methods used for integrated circuit fabrication).", "Additionally or alternatively, the curved optical element could be bonded to the circuit board using an adhesive, clips, an armature, or some other means.", "This could include bonding the curved optical element (e.g., using an adhesive) to the circuit board directly, to a package that encloses the circuit board (e.g., a ceramic, metal, or polymer integrated circuit package that includes a window), or to some other component of a light emitter.", "A light emitter could include further optical elements in addition to the curved optical element; for example, a plurality of microlenses could be provided on the surface of the circuit board to focus, collimate, or otherwise modify the emission pattern of light emitted from each of the individually addressable light-emitting elements.", "As noted above, a light emitter (e.g., 100) could be operated to provide a number of different patterns of illumination, during respective different periods of time, to an environment.", "The patterns of illumination could be specified such that an intensity of illumination received over time by an object in the environment (e.g., by a light detector of such an object), from the light emitter, could be used to determine the location of the object within the environment (e.g., to determine the angle of the object relative to the light emitter).", "This could involve determining a pattern of light incident on the object during different periods of time corresponding to different illumination patterns.", "The location of the object (e.g., the angle of the object relative to the light emitter) could then be determined by determining a region (e.g., a range of angles) within the environment that corresponds, based on the different patterns of illumination, to the pattern of received light.", "Other configurations of a light emitter are anticipated by the inventors.", "A circuit board could include a number of sets of interconnected individually addressable light-emitting elements (e.g., at least one hundred sets) such that the sets of individually addressable light-emitting elements could be operated to produce respective different patterns of illumination to facilitate determination of the location of an object in an environment that receives the patterns of illumination.", "Such sets of one or more individually addressable light-emitting elements could be interconnected with each other and/or with electrical pads of a circuit board in a variety of ways.", "For example, each set of individually addressable light-emitting elements could be connected to a respective pair of electrical pads of the circuit board, or a number of sets could be connected in common to a single electrical pad (e.g., according to a common-cathode arrangement or a common-anode arrangement).", "Additionally or alternatively, pairs of sets of one or more individually addressable light-emitting elements could share one or more electrical pads, being connected to such shared terminals according to an opposite polarity (that is, the anodes of the individually addressable light-emitting elements of a first set could be connected to an in-common terminal while the cathodes of the individually addressable light-emitting elements of a second set could be connected to the in-common terminal) such that each set of such a pair could be operated, during a respective period of time, to provide a respective pattern of illumination by providing voltage of a corresponding polarity to the in-common terminal(s).", "Other configurations of electrical pads on a light emitter, as described herein, are anticipated by the inventors.", "FIG.", "2 illustrates, in cross-section, the effect of a curved optical element (e.g., the cylindrical lens 102 illustrated in FIG.", "1) of a light emitter 100 on light emitted from individually addressable light-emitting elements 114 on a circuit board 110 of the light emitter 100.Note that the dimensions, angles of emitted illumination, operation of the cylindrical lens 102 to refract light, and other aspects of FIG.", "2 are intended to conceptually illustrate the production of patterns of illumination (e.g., substantially linear illumination patterns) by a light emitter as described herein and are not intended to literally represent optical or other properties (e.g., angles or locations of rays of light, emission patterns of LEDs, apparent refractive indices of optical elements, focal lengths of refractive elements, an overall divergent or convergent character of a refractive element and/or of a light field produced by such an element, angles of refraction of rays of light by refractive elements) of a particular embodiment of such a light emitter.", "FIG.", "2 shows a top view of a cross-section through the circuit board 110 and the cylindrical lens 102 of the light emitter 100.A first set of one or more individually addressable light-emitting elements 114 of the circuit board 110 are projecting light toward the cylindrical lens 102, as shown.", "The cylindrical lens 102 is configured to focus, refract, deflect, or otherwise modify light emitted from individually addressable light-emitting elements 114 such that a substantially linear illumination pattern is produced (e.g., at a measurement plane 202 where a light detector may be located) by the operation of such individually addressable light-emitting elements 114.The substantially linear illumination pattern may vary across an angular range according to the location on the circuit board 110, an emission profile, or other properties of the individually addressable light-emitting elements 114 on the circuit board 110 and/or the location and orientation of the individually addressable light-emitting elements 114 relative to the cylindrical lens 102.Properties of the cylindrical lens 102, the emitter 100 (e.g., an emission profile of the individually addressable light-emitting elements 114), or other elements of the light emitter 100 could be specified such that the width of the substantially linear illumination patterns intersecting the measurement plane 202 are wider or narrow, for example.", "As illustrated in FIG.", "2, each of the individually addressable light-emitting elements 114 may project a pattern through the cylindrical lens 102.The patterns may be substantially linear when projected onto the vertical/horizontal plane at the measurement surface 202 (i.e., the illumination patterns may be elongated in the vertical dimension and focused in the horizontal dimension).", "The individually addressable light-emitting elements 114 may be arranged with respect to one another to such that the angular range can be spanned.", "The angular range may span 30 degrees, 45 degrees, 60 degrees, 75 degrees, or 90 degrees, when defined with respect to the light emitter 100, for example.", "As illustrated in FIG.", "1, the array of individually addressable light-emitting elements and/or the circuit board 110 on which they are mounted may be curved.", "The curved array can be disposed, at least partially, concentrically about the cylindrical lens 102, as in FIG.", "2.Such a curvature can increase the span of the angular range (i.e., field of view) that can be illuminated by the light emitter at the measurement surface 202 when compared with a planar array of individually addressable light-emitting elements.", "Additionally, the curved nature of the array can further separate the light rays emitted by adjacent individually addressable light-emitting elements than the light rays would be separated with a planar array.", "This additional separation can lead to an increased spatial resolution at the measurement surface 202, for example.", "In various embodiments, the angular span of the curved array about the cylindrical lens could be more or less than is illustrated in the embodiment of FIG.", "2.For example, the curved array could surround 90 degrees, 135 degrees, or 180 degrees of the cylindrical lens.", "FIG.", "3 is a perspective illustration of a light emitter (e.g., the light emitter 100 illustrated in FIG.", "1) sequentially projecting illumination patterns into an environment 302 (e.g., a room).", "The light emitter may include a cylindrical lens 102 and a circuit board 110, with individually addressable light-emitting elements 114 thereon (occluded from view), for example.", "The cylindrical lens 102 may focus the light emitted by the individually addressable light-emitting elements 114 to produce substantially linear illumination patterns at corresponding angles with respect to the light emitter 100.As the individually addressable light-emitting elements 114 are sequentially activated, the substantially linear illumination may progress through an angular range with respect to the light emitter 100 (as indicated in FIG.", "1 by the dashed arrows).", "In various embodiments, the angular range may vary in the horizontal/depth plane or in the vertical/depth plane (e.g., if the light emitter 100 were rotated 90 degrees in the horizontal/vertical plane.).", "The angular range may span 15 degrees, 30 degrees, 45 degrees, 60 degrees, 75 degrees, 90 degrees, 105 degrees, 120 degrees, 135 degrees, 150 degrees, 165 degrees, or 180 degrees in various embodiments.", "Other angular range spans are possible.", "The spacing between, width, and location of the substantially linear illumination patterns illustrated in FIG.", "3 are provided as an example, and are not meant to indicate a preferred embodiment.", "It will be readily understood that multiple projection patterns are possible when sequentially illuminating the individually addressable light-emitting elements 114.In some embodiments, for example, the interstitial space between adjacent substantially linear illumination patterns may be smaller than illustrated.", "In one such embodiment, the substantially linear illumination patterns may be projected conterminously to one another (e.g., the left edge of one of the substantially linear illumination patterns may lie immediately adjacent to the right edge of an adjacent substantially linear illumination pattern).", "This may allow, if all of the individually addressable light-emitting elements were activated simultaneously for example, a synchronization pulse to vertically illuminate the entire portion of the environment 302 that lies within the angular range.", "Determination of the location of an object (e.g., determination of the angle of a light detector in the first direction relative to the light emitter 100) based on time-varying patterns of illumination received from the light emitter 100 can include determining the timing of detection of the illumination (e.g., the timing of detection of a given light intensity from a plurality of measurements of the intensity of light received by a light detector) relative to the timing of time periods during which each of a number of different patterns of illumination are produced by the light emitter 100.In some examples, such timing information could be determined by the light emitter 100 and a light detector 420 both including highly accurate, synchronized clocks.", "In other examples, the light emitter 100 could include a radio frequency transmitter (or other means for wireless information transmission) that is operated to emit such timing information.", "In still further examples, such timing information could be recovered from the time-varying pattern of illumination received by a light detector from the light emitter 100.In some embodiments, the timing information could be recovered by recovering pulse timing information from changes (e.g., rising or falling edges) in a detected time-varying illumination signal.", "As illustrated in FIG.", "4, the light emitter 100 may emit light into an environment 302 (e.g., a room) in the form of substantially linear illumination patterns (as illustrated in FIG.", "3).", "This could be accomplished by the light emitter 100 using a curved optical element (e.g., a cylindrical lens 102) and a series of individually addressable light emitting elements 114 (occluded from view in FIG.", "4) arranged into an array on a circuit board 110, for example.", "As the individually addressable light emitting elements 114 are sequentially activated (e.g., by a control system also on the circuit board 110 connected to the individually addressable light-emitting elements 114 using electrical interconnects), substantially linear illumination patterns may illuminate different angles within an angular range defined by the light emitter 100 in the environment 302.The sequential scanning is illustrated in FIG.", "4 by the dashed arrows.", "Further, the locations where substantially linear illumination patterns could be projected are illustrated by the solid lines emanating from the cylindrical lens 102.The substantially linear illumination pattern that is projected to the angular position of the light detector 420 is indicated in FIG.", "4 by reference numeral 402.As described above, determining the location of an object (e.g., the light detector 402) based on a detected time-varying intensity of light received from a light emitter can include making such determinations based on information about the timing of patterns of illumination emitted from the light emitter.", "Such timing information could be based on an internal clock of a controller of the light detector, or based on timing information received using a receiver (e.g., timing information transmitted via radio frequency signals from the light emitter).", "Additionally or alternatively, the timing information could be present in the timing of emission of patterns of illumination by the light emitter.", "For example, the light emitter could provide illumination to all of the angular range of illumination during one or more particular periods of time to provide synchronization timing or other data to an object.", "In some examples, providing one or more of the patterns of illumination could include modulating one or more of the provided patterns of illumination (e.g., by varying an intensity of the provided illumination across a range of intensities and/or between a number of different discrete levels of illumination) at a specified frequency or according to some other pattern over time to provide timing information (e.g., to identify one or more of the patterns of illumination as a ‘first’ pattern in a sequence of patterns of illumination) or to provide some other information.", "Note that the detected substantially linear illumination pattern 402, as illustrated, is intended as a non-limiting example of a pattern that could be provided by the light emitter 100 as described herein.", "As an alternate example, a set of patterns of illumination provided by light emitter could vary across a first range of angles; a further pattern of illumination could provide illumination to all of the first range of angles.", "Such a pattern could be provided, as described above, to provide timing or other information to objects in the environment.", "Additionally or alternatively, such a pattern of illumination could be used to determine whether a given object is within the first range of angles and thus whether the light emitted from the light emitter can be used to determine the location of the given object.", "A number of different patterns of illumination (and corresponding number of sets of one or more individually addressable light-emitting elements of a light emitter) could be specified to provide determination of the angular position of an object in an environment of interest to at least a specified resolution or accuracy.", "For example, ten or more different substantially linear illumination patterns could be provided by a light emitter (e.g., from ten or more corresponding sets of one or more light emitting elements of the light emitter) during respective different periods of time (e.g., during a plurality of repeated respective periods of time, according to a repeating sequence in time of producing the different substantially linear illumination patterns).", "Each of the provided substantially linear illumination patterns, when detected by a light detector of an object in the environment during a respective period of time, could provide a corresponding angular range in which the object is located relative to the light emitter.", "The angular range in which the object is located may occupy a span of angles based on the width of the corresponding substantially linear illumination pattern.", "As noted above, the number of provided different patterns of illumination could be specified to facilitate determination of the angular position of such an object to a specified degree of resolution.", "For example, providing ten or more different substantially linear illumination patterns could facilitate the determination of the angular position of an object to a resolution of 9 degrees if the complete angular range swept out by the light emitter were 90 degrees.", "An angular resolution of 9 degrees may correspond to a linear distance resolution of 15.6 centimeters when such an object is within 1 meter of a light emitter that is providing the substantially linear illumination patterns.", "Additionally, if the intensity profile of the substantially linear illumination patterns vary with respect to angle (e.g., due to the Gaussian nature of an individually addressable light-emitting element, such as a laser), and a light detector on the object can detect the variations in intensity, the angular resolution could be enhanced further.", "FIG.", "5 is a block diagram of a system that includes a light emitter 550 that is configured to provide a plurality of different patterns of illumination as described elsewhere herein to an environment within which an object 510 is located.", "The object 510 includes a light detector 514 and a controller 512 configured to detect illumination 520 emitted from the light emitter 550.The object 510 further includes a transceiver 516 configured to transmit and/or receive information to and/or from some other device (e.g., from the light emitter 550).", "The light detector 514 is configured to detect a property (e.g., an intensity) of light 520 received from the light emitter 550 (e.g., light emitted as one or more substantially linear illumination patterns from the light emitter 550 during respective different periods of time).", "Such light can be detected and used to determine a location (e.g., an angle in a first direction relative to the light emitter 550) of the object 510.The light emitter 550 includes a die 554, which could be disposed on a circuit board for example, that includes one or more individually addressable light-emitting elements configured to provide light, via a curved optical element 556 (e.g., a cylindrical lens), to reproduce respective patterns of illumination to an environment that contains the object 510 (e.g., substantially linear illumination patterns).", "The light emitter 550 further includes a processor 552 and a memory 560 configured to facilitate operation of the die 554 to produce such patterns of illumination.", "The light emitter 550 is configured to produce, during respective periods of time, different patterns of illumination.", "Emitting each different pattern of illumination includes emitting illumination within one or more ranges of angles of a first range of angles in a first direction relative to the device.", "Thus, each pattern of illumination varies across the first direction such that an object (e.g., 510) can detect the intensity of light received from the light emitter 550 during such different periods of time and use the detected light intensities to determine the location of the object 510 in an environment (e.g., to determine the angle of the object 510 relative to the light emitter 550 in the first direction).", "The light emitter 550 producing a particular pattern of illumination includes generating light from a set of one or more interconnected individually addressable light-emitting elements (e.g., LEDs, lasers, VCSELs) of the die 554.The processor 552 of the light emitter 550 is configured to operate the die 554 (e.g., to apply voltages and/or currents to the different sets of one or more individually addressable light-emitting elements of the die 554) to produce different patterns of illumination from the light emitter 550.The processor 552 could include one or more microcontrollers, application-specific integrated circuits (ASICs), field-programmable gate arrays (FPGAs), or other electronic components configured to operate the die 554 to produce different patterns of illumination during different periods of time.", "The processor 552 could include elements configured to performs such actions using program instructions 562 or other information contained within the memory 560 (e.g., to generate a sequence of patterns of illumination according to a stored pseudo-random sequence or according to some other sequence, or to indicate some timing information or other information by emitting illumination 520 using the die 554).", "Alternatively, the light emitter 550 could include, instead of the processor 552 and memory 560, a number of flip-flops, timers, multiplexers, counters, or other circuits configured to operate the die 554 to produce patterns of illumination according to a sequence that is statically set by the structure of such circuits (e.g., to provide each of a set of patterns of illumination for a specified period of time in a repeating sequence).", "The memory 560 can include program instructions 562 for execution by the processor 552 to cause the light emitter 550 to produce different patterns of illumination during respective different periods of time by emitting light from respective different sets of one or more individually addressable light-emitting elements on the die 554 or to perform some other operations.", "The memory 560 may include non-volatile and/or volatile memory, in various embodiments.", "In some examples, the program instructions 562 could include instructions to provide the different patterns of illumination according to a set sequence (e.g., such that each of the different patterns of illumination are presented repeatedly in turn).", "Alternatively, the program instructions 562 could include instructions to provide the different patterns of illumination according to a random or pseudorandom sequence.", "In yet another example, the program instructions 562 could include instructions to provide a subset of the different patterns of illumination.", "For example, if the location of an object is known to a low resolution (e.g., it is known that the object is located within a second half of a range of angles of interest based on detecting light previously emitted from the light emitter 550), only a subset of different patterns of illumination could be provided to facilitate determination of the location of the object to a greater resolution and/or at a higher rate over time.", "In a still further example, program instructions 562 could include instructions to provide illumination across a range of angles of interest to signal some information to objects in an environment.", "Signaling information to objects could include indicating timing information about previous or subsequent patterns of illumination emitted from the light emitter 560 or providing information about the identity or other information about patterns of illumination emitted from the light emitter 550 and/or information about the order of production of such patterns (e.g., a seed value or other information about a pseudorandom sequence of patterns of illumination).", "In some examples, the light emitter 550 could include a transceiver, a communications interface, a user interface, one or more further dies, or some other components, and the program instructions 562 could include instructions to operate such further components to provide some functionality.", "For example, the light emitter 550 could include a transceiver configured to communicate with the object 510 (e.g., via the transceiver 516 of the object 510).", "The program instructions 562 could include instructions to operate the transceiver to transmit timing information, information about patterns of illumination and/or a sequence of production of such patterns by the light emitter 550, or some other information to the object 510.Additionally or alternatively, the program instructions 562 could include instructions to operate the transceiver to receive location information determined by the controller 512 of the object 510 based on light intensities detected using the light detector 514, to transmit information about such detected intensities such that the processor 552 can determine the location of the object 510 based on such detected intensities, or to receive some other information from the object 510.The program instructions 562 could include instructions to operate such a transceiver to communicate with some other systems (e.g., to transmit information about a determined location of the object 510 to a phone, a computer, or some other system).", "The light emitter 550 can be part of a smart phone, digital assistant, head-mounted display, controller for a robot or other system, or some other portable computing device.", "In such examples, the light emitted from the light emitter 550 (e.g., as different patterns of illumination) could be used to determine the location of objects (e.g., of objects including light detectors) relative to such other objects (e.g., the location of a user's hand, on which is disposed a light detector, relative to a user's head, on which a head-mounted display including the light emitter 550 is disposed).", "Alternatively, the light emitter 550 can be part of a system that is mounted to a floor, wall, ceiling, or other object or building such that the location of the light emitter 550 is relatively static relative to an environment of interest.", "In such examples, the light emitted from the light emitter 550 could be used to determine the location of objects (e.g., of objects including light detectors) relative to the environment (e.g., the location of segments of a person's body, on which are disposed a number of respective light detectors, to facilitate detection of motions of the person's body within the environment).", "Other configurations and/or applications of a light emitter as described herein are anticipated by the inventors.", "The object 510 could be part of or disposed on a system (e.g., a drone), a tag or other device attached to an object or person of interest (e.g., to a body segment of a person, to facilitate motion capture), or configured in some other way to facilitate determination of the location of the object 510 based on a time-varying intensity of light received from the light emitter 550.This includes detecting such an intensity of light using the light detector 514 of the object 510.The light detector 514 could include a photodiode, a phototransistor, or some other elements that are sensitive to light emitted from the light emitter 550 (e.g., to light at a wavelength corresponding to the wavelength of light emitted from individually addressable light-emitting elements of the die 554 of the light emitter 550).", "The controller 512 could include a variety of elements configured to operate the light detector 514 to detect the intensity or other properties of light received from the light emitter 550 and/or to perform some other operations.", "For example, the controller 512 could include logic gates, arithmetic logic units, microprocessors, registers, digital oscillators, counters, logical buses, amplifiers, analog-to-digital converters (ADCs), mixers, analog oscillators, buffers, memories, program instructions, or some other component or components.", "The controller 512 could be configured to determine the location of the object 510 based on such detected illumination from the light emitter 550 and/or to transmit, using the transceiver 516, information about the detected illumination (e.g., about the intensity of the received illumination at a plurality of points in time, about the timing, sequence, or other information about a series of changes in the intensity of such received illumination over time) to some other system (e.g., the light emitter 550, a phone, a computer.", "The controller 512 could be configured to perform some other operations.", "The controller 512 could include a variety of components used to detect illumination from the light emitter 550 that is received by the light detector 514.The light detector 514 could include a photodiode, a phototransistor, a photoresistive element, or some other components configured to output a voltage, a current, or some other electrical signal related to the intensity or other properties of the received light 520.The controller 512 could include amplifiers, transimpedance amplifiers, filters, buffers, voltage references, ADCs, or other components configured to operate the light detector 514 to detect the illumination 520 received from the light emitter 550.The controller 512 could include further circuitry (e.g., clock recovery circuitry to determine relative timing information from transitions in the intensity of the detected illumination, asynchronous serial receiver circuitry to detect a sequence of changes in the intensity of the received illumination that are relative to the location of the object 510).", "The controller 512 could be configured to detect, using the light detector 514, illumination from multiple light emitters and/or from multiple different dies of a light emitter.", "In some examples, the controller 512 could include digital or analog filters configured to facilitate detecting illumination received from multiple different light emitters and/or from multiple different dies of a light emitter.", "This could be done by detecting components of the illumination received by the light detector 514 that vary at respective different frequencies corresponding to frequencies of modulation of the illumination emitted from such different dies and/or different light emitters.", "Additionally or alternatively, the light detector 514 could include multiple different light-sensitive elements (e.g., different photodiodes and/or optical filters coupled to such photodiodes) that are sensitive to illumination at respective different wavelengths corresponding to the wavelength of illumination produced by different light emitters and/or different dies of a light emitter.", "This could facilitate detection of illumination received from such multiple different light emitters and/or from multiple different dies of a light emitter.", "It is noted that the block diagram shown in FIG.", "6 is described in connection with functional modules for convenience in description.", "However, embodiments of the object 510 and/or the light emitter 550 can be arranged with one or more of the functional modules (“sub-systems”) implemented in a single integrated circuit (e.g., an integrated circuit that includes a light detector and circuitry for detecting an intensity of light received via the light detector), multiple integrated circuits or electronic assemblies (e.g., printed circuits boards with electronic components disposed thereon), or according to some other consideration.", "Note that the illustrated components of the object 510 and the light emitter 550 are intended as a non-limiting example embodiment.", "Also note that light emitters configured to provide patterns of illumination to an environment, objects located in such an environment, and/or light detectors located in such an environment as described herein may include more or fewer of the illustrated elements and/or may include further elements.", "For example, an object that is located in an environment and that includes a light detector configured to detect light emitted from a light emitter may lack a controller or other elements configured to operate the light detector and/or to determine the location of the object.", "In such examples, the light emitter could be tethered via a cable to some other system (e.g., to the light emitter 550) that is configured to detect the light received via the light detector and to determine the location of the light detector.", "Further examples of light emitters, light detectors, tags, and/or other objects or systems configured to produce and/or detect patterns of illumination as described herein are anticipated by the inventors.", "As described elsewhere herein, a light emitter could include a die and a curved optical element configured to provide patterns of illumination from the light emitter that vary according to angle in a specified direction relative to the light emitter.", "This could be done by generating light from corresponding individually addressable light-emitting elements of the die.", "The location of such individually addressable light-emitting elements on the die could correspond to the angle or range of angles of illumination produced from the light emitter when the individually addressable light-emitting elements are operated to emit light.", "A light emitter configured in this way can provide such patterns more efficiently, in a smaller form factor, with minimal components and for minimal cost, or according to some other consideration in a manner that is improved relative to other apparatuses or methods for producing such patterns of illumination (e.g., using a digital micromirror device to control which portions of light produced by a light source will be provided to an environment).", "Such a die and/or curved optical element could be configured in a variety of ways to facilitate production of a variety of different patterns of illumination.", "For example, while such a light emitter is described elsewhere herein as including a single die that is disposed relative to a curved optical element, multiple dies could be disposed relative to such a curved optical element.", "These multiple dies could provide respective patterns of illumination from respective sets of light-emitted elements of the different dies.", "Such different dies could be provided to increase a degree of power dissipation from the dies, to increase a total number of sets of individually addressable light-emitting elements on the dies and corresponding total number of different patterns of illumination that can be provided by the light emitter, or to provide some other functionality.", "This is illustrated by way of example in FIG.", "7, which shows a first die 714 and a second die 724 that each include respective pluralities of light-emitting elements and are each set behind a first curved optical element 710 and a second curved optical element 720, respectively.", "As described above, FIG.", "6a is a top view of an array of individually addressable light-emitting elements 614 arranged on a circuit board 610 that project light toward a cylindrical lens 602.If sequentially activated, the array of individually addressable light-emitting elements 614 may repeatedly project the substantially linear illumination pattern across an angular range with respect to the light emitter (as illustrated by the arrow).", "The angular range swept out by the light emitter in FIG.", "6a lies in the horizontal/depth plane (axes indicated in FIG.", "6a).", "As indicated, the individually addressable light-emitting elements 614 are arrayed on the circuit board 610 along a curved axis lying within the horizontal/depth plane.", "Additionally, the primary axis of the cylindrical lens 602 lies substantially parallel to the vertical axis.", "Alternatively, the same light emitter could be used to project substantially linear illumination patterns that scan an angular range that lies in the vertical/depth plane (axes indicated in FIG.", "6b).", "As illustrated in FIG.", "6b, the light emitter is reoriented such that the individually addressable light-emitting elements 664 are arrayed on the circuit board 660 along a curved axis lying within the vertical/depth plane.", "Additionally, the primary axis of the cylindrical lens 652 lies substantially parallel to the horizontal axis.", "In addition, if the two emitter configurations presented in FIGS.", "6a and 6b were two separate emitters, they could simultaneously scan orthogonal angular ranges.", "Further, the two separate emitters could be placed on a single circuit board to scan an environment, as illustrated in FIG.", "7.As discussed above, in some embodiments of a light emitter (e.g., the light emitter 700 illustrated in FIG.", "7), there may be a first curved array of individually addressable light-emitting elements 714 disposed behind a first cylindrical lens 710 on the same circuit board as a second curved array of individually addressable light-emitting elements 724 disposed behind a second cylindrical lens 720.The first and second curved arrays could be oriented such that the curved arrays emit respective patterns of illumination in first and second directions, respectively, such that the first and second directions are rotated relative to each other (e.g., such that the first and second directions are substantially orthogonal, that is, such that the first and second directions differ by between 80 degrees and 100 degrees).", "This could allow a light detector to determine the angle of the object relative to the light emitter in two orthogonal directions.", "In another example, the two curved arrays of the light emitter could be located at different locations in the environment, and determining the location of the object based on the illumination received by the object from the two arrays could include determining that the object is located on a particular plane or line within the environment based on the detected illumination and also based on the relative locations and orientations of the two curved arrays within the environment.", "Furthermore, in other embodiments, three or more curved arrays of individually addressable light-emitting elements with three or more curved optical elements could be employed across one or more light emitters.", "Illumination received by an object (e.g., by a light detector of the object) from two (or more) different arrays and/or light emitters could be detected in a variety of ways.", "In an example embodiment, the different arrays could emit patterns of illumination during different respective periods of time.", "In such an example, detecting the illumination from the two different arrays could include operating a light detector of the object to detect light received by the object during the different respective periods of time.", "In another example, the different arrays could emit illumination at different respective wavelengths and detecting the illumination from the two different arrays could include operating multiple light detectors (e.g., light detectors coupled to respective wavelength-selective filters corresponding to the different wavelengths of the light emitted by the light emitters) of the object to detect light incident on the object at the different respective wavelengths.", "In yet another example, the illumination emitted from each of the arrays could be modulated at a different respective frequency, and detecting the illumination from the two different light emitters could include filtering a light intensity signal detected using a light detector of the object at the different respective frequencies.", "Additional or alternative methods of detecting the intensity over time of light received by an object from two or more arrays as described herein are anticipated by the inventors.", "Furthermore, the cylindrical lenses 710/720 and the corresponding curved arrays of individually addressable light-emitting elements 714/724 could be packaged onto a circuit board 700.The circuit board 700 may include communication interconnects 702 for transmitting modulation signals to the individually addressable light-emitting elements 714/724 from a control system 760 (e.g., a control system 760 that includes a processor 762 configured to execute instructions stored on a memory 764 to generate illumination patterns to scan an environment).", "The circuit board 700 may also include power interconnects 702 that provide a supply voltage to the individually addressable light-emitting elements 714/724 from a power supply 770.The power supply 770 may include batteries or ultra-capacitors, in some embodiments.", "In alternate embodiments, the power supply 770 may include a plug configured to connect to a wall socket and an alternating current to direct current (AC to DC) converter.", "III.", "Example Methods FIG.", "8 is a flowchart of a method 800 for operating a light emitter to produce patterns of illumination as described elsewhere herein.", "Such patterns of illumination can be provided, during respective periods of time, to facilitate determining the location of objects, in a first direction relative to the light emitter, based on illumination received by the objects over time from the light emitter.", "The patterns of illumination are specified to spatially encode the environment of the light emitter such that different regions of the environment (e.g., different ranges of angles in the first direction, relative to the light emitter) receive different time-varying patterns of illumination from the light emitter.", "Such a time-varying pattern can be detected and used to determine which of the regions of the environment the time-varying pattern was detected from, and thus to determine the location (e.g., the angle in the first direction) of a light detector or other apparatus used to detect the time-varying pattern with respect to the light emitter.", "The light emitter includes a number of sets of one or more interconnected individually addressable light-emitting elements that are disposed in an array of the light emitter and that each correspond to a respective one of the patterns of illumination emitted from the light emitter.", "The array is disposed relative to a curved optical element of the light emitter such that, when a particular set of one or more interconnected individually addressable light-emitting elements of the array is operated to emit light, the emitted light is focused by the curved optical element to produce a corresponding one of the patterns of illumination from the light emitter.", "At block 802, the method 800 includes emitting light from a first individually addressable light-emitting element toward a curved optical element.", "Block 802 could include providing a voltage difference across the first individually addressable light-emitting element, in some embodiments.", "Further, the light emitted from the first individually addressable light-emitting element could be at a corresponding intensity and/or a corresponding wavelength determined by a control system, for example.", "The corresponding intensity and/or the corresponding wavelength could be based on a location within an environment to which the emitted light will be directed (e.g., the emitted light directed toward the center of an angular range of the environment could have a greater intensity than emitted light directed toward the edges of the angular range).", "At block 804, the method 800 includes focusing, by the curved optical element, the light emitted from the first individually addressable light-emitting element to produce a substantially linear illumination pattern at a first corresponding scan angle within an angular range.", "Block 804 may include focusing the light emitted by the first individually addressable light-emitting element in one direction (e.g., horizontally) and spreading the light in an orthogonal direction (e.g., vertically).", "In order to accomplish this, the curved optical element could be a cylindrical lens, in some embodiments.", "The substantially linear illumination pattern may extend in one dimension (e.g., vertically) across a dimension of the environment (e.g., a wall within a room).", "The width of the first corresponding scan angle within the angular range may correlate to the width of a projecting surface on the first individually addressable light-emitting element.", "Alternatively, the width of the first corresponding scan angle within the angular range may correlate to physical characteristics of the light emitted by the first individually addressable light-emitting element (e.g., beam waist of a laser beam or diffraction limit of the wavelength emitted by the first individually addressable light-emitting element).", "At block 806, the method 800 includes emitting light from a second individually addressable light-emitting element toward the curved optical element.", "Similar to block 802, the light emitted from the second individually addressable light-emitting element could be at a corresponding intensity and/or a corresponding wavelength.", "The corresponding intensity and/or corresponding wavelength may correlate to a given location within the environment toward which the light emitted by the second individually addressable light-emitting element will be projected.", "In some embodiments, the second individually addressable light-emitting element could be disposed immediately adjacent to the first individually addressable light-emitting element, within an array, for example.", "Furthermore, the first and the second individually addressable light-emitting elements could both be located on a circuit board.", "The first and the second individually addressable light-emitting elements could further be staggered with respect to one another such that a first projecting surface on the first individually addressable light-emitting element and a second projecting surface on the second individually addressable light-emitting element are aligned with one another.", "Additionally or alternatively, the first and the second individually addressable light-emitting elements could be located at different concentric positions about the curved optical element (e.g., both the first and the second individually addressable light-emitting elements could be the same distance from the curved optical element, but disposed at different angular locations around the curved optical element).", "At block 808, the method 800 includes focusing, by the curved optical element, the light emitted from the second individually addressable, light-emitting element to reproduce the substantially linear illumination pattern at a second corresponding scan angle within an angular range.", "Similar to block 804, focusing could include focusing the light in one direction (e.g., horizontally), and spreading the light in an orthogonal direction (e.g., vertically).", "The reproduced substantially linear illumination pattern could be projected on a portion of the environment that lies immediately adjacent to the substantially linear illumination pattern projected by block 804, for example.", "This may occur if the respective first and second projecting surfaces of the first and second individually addressable light-emitting elements are aligned.", "The method 800 could include further steps, wherein further patterns of illumination are generated, during respective periods of time, from the light emitter by generating light from respective further sets of one or more interconnected individually addressable light-emitting elements of the light emitter.", "Such further patterns of illumination could be provided to increase a resolution to which the location of a light detector or other object in the environment can be determined (e.g., by providing patterns of illumination that provide illumination selectively to smaller portions of the environment).", "Further, the method 800 could include a step providing illumination, during a particular one or more periods of time, to all of the first range of angles (e.g., to provide synchronization or timing information to light detectors or other objects receiving such illumination).", "The method 800 could additionally include providing, via one or more provided patterns of illumination, optical transmissions of information to light detectors in the environment.", "Still further, the method 800 could include providing, via radio frequency transmissions, information about the timing, sequence, angles of an environment illuminated, or other information about patterns of illumination provided, during respective different periods of time, from the light emitter.", "The method 800 could include further steps, or steps alternative to those listed here.", "FIG.", "9 is a flowchart of a method 900 for illuminating an environment by a light emitter and detecting an angular position within the environment where an object (e.g., a light detector) is located.", "The light emitter and the object could comprise a location detection system.", "The patterns of illumination may be specified to spatially encode the environment of the light emitter such that different regions of the environment (e.g., different ranges of angles in the first direction, relative to the light emitter) receive different time-varying patterns of illumination from the light emitter.", "Furthermore, the light emitter and the object could communicate with each other in additional ways beyond the illumination and detection of illumination patterns within the environment.", "The light emitter includes a number of sets of one or more interconnected individually addressable light-emitting elements that are disposed in an array of the light emitter and that each correspond to a respective one of the substantially linear illumination patterns emitted from the light emitter.", "The array is disposed relative to a curved optical element of the light emitter such that, when a particular set of one or more interconnected individually addressable light-emitting elements of the array is operated to emit light, the emitted light interacts with the curved optical element to produce a corresponding one of the substantially linear illumination pattern from the light emitter.", "At block 902, the method 900 includes emitting a synchronization illumination from an array.", "Block 902 may include illuminating a plurality of individually addressable light-emitting elements within the array (e.g., all of the individually addressable light-emitting elements within the array).", "Further, the plurality of individually addressable light-emitting elements within the array could emit light in a series of pulses, modulated at a corresponding synchronization frequency, intensity, and/or pattern.", "The corresponding synchronization frequency, intensity, and/or pattern could be recognizable by one or more light detectors, for example, as a way of determining that the illumination provided by the individually addressable light-emitting elements in the array in block 902 is a synchronization illumination.", "At block 904, the method 900 includes detecting the synchronization illumination using a light detector.", "The light detector could be disposed at a particular angular position within an environment.", "As described above, the light detector could include a controller, such as a processor executing instructions stored within a memory, for example.", "Furthermore, the light detector could include a photodiode, a phototransistor, a photoresistive element, or some other component(s) configured to output a voltage, a current, or some other electrical signal related to the intensity, wavelength, or other properties of the received light.", "In some embodiments of method 900, block 904 could include detecting the synchronization illumination from a plurality of light detectors.", "For example, an object within the environment may have multiple light detectors positioned at different angular positions on the object (e.g., a light detector on the left arm and another light detector on the right arm of a person).", "Further, detecting the synchronization illumination could include detecting a corresponding wavelength, intensity, and/or duration of illumination.", "Additionally, detecting the synchronization illumination could include detecting a wavelength and/or intensity profile with respect to time.", "Detecting such a profile could allow the light detector to more precisely pinpoint the angular position of the light detector within the environment.", "At block 906, the method 900 includes associating a synchronization time with the detected synchronization illumination.", "Block 906 could include a transceiver associated with the light detector accessing a network (e.g., the public Internet) to determine the current time.", "Alternatively, the light detector could have an internal clock that stores the current time.", "Block 906 may also include storing the associated synchronization time in a memory.", "The memory could be located on-board the light detector, in some embodiments.", "Alternatively, the memory could be located remotely (e.g., a cloud storage device to which the light detector communicates the synchronization time).", "At block 908, the method 900 includes sequentially illuminating the individually addressable light-emitting elements in the array using a control system to sweep out an angular range with a substantially linear illumination pattern.", "In some embodiments, block 908 may include illuminating different individually addressable light-emitting elements for different amounts of time.", "For example, the first individually addressable light-emitting element in the array could be activated for 500 milliseconds, and each successive individually addressable light-emitting element could be activated for 5 fewer milliseconds, consecutively.", "Such an illumination scheme could allow one or more light detectors to detect their respective angular positions relative to the light emitter.", "In addition to a modulation in time, a modulation in wavelength (e.g., each of the individually addressable light-emitting elements emits a slightly different wavelength of light) could be used during the sequential illumination of the individually addressable light-emitting elements in the array.", "At block 910, the method 900 includes detecting the substantially linear illumination pattern reproduced by one of the light-emitting elements in the array using the light detector.", "Similarly to block 904, detecting the substantially linear illumination pattern could include detecting a corresponding wavelength, intensity, and/or duration of illumination.", "Further, detecting the substantially linear illumination pattern could include detecting a wavelength and/or intensity profile with respect to time.", "Detecting such a profile could allow the light detector to more precisely pinpoint the angular position of the light detector within the environment.", "At block 912, the method 900 includes associating the detected substantially linear illumination pattern with a detection time.", "If a wavelength and/or intensity profile were detected with respect to time, block 912 could include associating the substantially linear illumination pattern with a set of detection times.", "Analogously to block 906, block 908 could include a transceiver associated with the light detector accessing a network (e.g., the public Internet) to determine the current time.", "Alternatively, the light detector could have an internal clock that stores the current time.", "Block 908 may also include storing the associated detection time in a memory.", "The memory could be located on-board the light detector, in some embodiments.", "Alternatively, the memory could be located remotely (e.g., a cloud storage device to which the light detector communicates the synchronization time).", "At block 914, the method 900 includes comparing the detection time with the synchronization time to determine the angular position of the light detector, using a computing device.", "The computing device could be located on-board the light detector, in some embodiments.", "In alternate embodiments, the computing device could be a central server, for example, that determines the angular positions of multiple light detectors based on multiple respective detection times and synchronization times.", "The computing device, in such embodiments, may communicate with the light detector through a transceiver on the light detector, for example.", "Block 914 may include the computing device subtracting the synchronization time from the detection time to determine a time duration between when the synchronization illumination was detected and when the substantially linear illumination pattern was detected.", "Further, block 914 may include the computing device dividing the time duration between the synchronization illumination detection and the substantially linear illumination pattern detection by an illumination time of each of the individually addressable light-emitting elements in the emitter to determine the angular position of the light detector.", "The illumination time of each of the individually addressable light-emitting elements may have previously been transmitted from the light emitter to the light detector.", "Additionally or alternatively, the illumination time may have been generated/altered based on information contained within the synchronization illumination (e.g., the wavelength of the synchronization illumination serves as an indication from the light emitter to the light detector as to the illumination time of each of the individually addressable light-emitting elements that is used in the corresponding illumination sequence).", "The method 900 could include further steps, wherein further patterns of illumination are generated, during respective periods of time, from the light emitter by generating light from respective further sets of one or more interconnected individually addressable light-emitting elements of the light emitter.", "Such further patterns of illumination could be provided to increase a resolution to which the angular position of a light detector or other object in the environment can be determined (e.g., by providing patterns of illumination that provide illumination selectively to smaller portions of the environment).", "The method 900 could additionally include providing, via one or more provided patterns of illumination, optical transmissions of information to light detectors in the environment.", "Still further, the method 900 could include providing, via radio frequency transmissions, information about the timing, sequence, angles of an environment illuminated, or other information about patterns of illumination provided, during respective different periods of time, from the light emitter.", "The method 900 could include further steps, or steps alternative to those listed here.", "IV.", "Conclusion The particular arrangements shown in the Figures should not be viewed as limiting.", "It should be understood that other embodiments may include more or less of each element shown in a given Figure.", "Further, some of the illustrated elements may be combined or omitted.", "Yet further, an exemplary embodiment may include elements that are not illustrated in the Figures.", "Additionally, while various aspects and embodiments have been disclosed herein, other aspects and embodiments will be apparent to those skilled in the art.", "The various aspects and embodiments disclosed herein are for purposes of illustration and are not intended to be limiting, with the true scope and spirit being indicated by the following claims.", "Other embodiments may be utilized, and other changes may be made, without departing from the spirit or scope of the subject matter presented herein.", "It will be readily understood that the aspects of the present disclosure, as generally described herein, and illustrated in the figures, can be arranged, substituted, combined, separated, and designed in a wide variety of different configurations, all of which are contemplated herein." ] ]
Patent_15872875
[ [ "SYSTEMS AND METHODS FOR ALLOCATING AND PRICING ALTERNATIVE NETWORK ACCESS RESOURCES WITH RESERVE PRICES", "A method for allocating and pricing access to alternative access networks may include: inputting, by one or more parties, needs for alternative network access and representative values for satisfying the needs; setting, by providers of alternative network access, reserve prices for access to each of access point in the alternative network; generating a solution based on a mixed integer program to maximize value created by allocation of alternative network access; and allocating alternative network access to the one or more parties based on the mixed integer program solution." ], [ "1.A method comprising, by at least one hardware processor: receiving, from each of one or more parties, an offloading demand for access to an alternative network and a value of the offloading demand to the party; receiving, from each of a plurality of providers of access to the alternative network, a reserve price for access to one or more access points in the alternative network that are provided by the provider, wherein the reserve price is a minimum price that must be met on average across all of the one or more access points provided by that provider; and, for each of one or more sectors and each of one or more time slots, allocating at least one access point in the alternative network, in the sector and for the time slot, to at least one of the one or more parties based on the received values of the offloading demands and the received reserve prices, and, during the time slot, offloading one or more mobile devices, that are communicatively connected to a primary network of the at least one party within the sector, to the allocated at least one access point in the alternative network.", "2.The method of claim 1, wherein each offloading demand indicates at least one of the one or more sectors in association with at least one of the one or more time slots, and wherein each allocation of an access point to one of the one or more parties is for an access point within the at least one sector, indicated in the offloading demand received from that one party, during the at least one time slot associated with that at least one sector in the offloading demand received from that one party.", "3.The method of claim 1, further comprising, by the at least one hardware processor, determining all allocations by maximizing a value function associated with each of the one or more parties, wherein the value function associated with each of the one or more parties uses the received value of the offloading demand to that party.", "4.The method of claim 3, wherein the one or more parties comprise both one or more mobile network operators and one or more mobile virtual network operators, and wherein the value function associated with each of the one or more mobile network operators is different than the value function associated with each of the one or more mobile virtual network operators.", "5.The method of claim 1, wherein the primary network comprises a wireless cellular network, and wherein the alternative network comprises a Wi-Fi™ network.", "6.The method of claim 1, wherein network topologies of the primary network and the alternative network are different.", "7.The method of claim 1, wherein the allocation is performed for both short-term time slots and long-term time slots, and wherein access to the alternative network is allocated differently for a short-term time slot than for a long-term time slot.", "8.The method of claim 7, further comprising computing prices for each short-term time slot using a Vickrey-Clarke-Groves (VCG) mechanism.", "9.The method of claim 7, further comprising computing prices for each long-term time slot with core-selecting combinatorial auctions.", "10.The method of claim 1, wherein allocation for all of the one or more sectors and all of the one or more time slots is performed once a day.", "11.The method of claim 1, wherein each of the one or more time slots is one-hour long.", "12.The method of claim 1, wherein the one or more sectors comprise a plurality of sectors.", "13.The method of claim 1, wherein the one or more time slots comprise a plurality of time slots.", "14.A non-transitory computer-readable medium having instructions stored thereon, wherein the instructions, when executed by a processor, cause the processor to: receive, from each of one or more parties, an offloading demand for access to an alternative network and a value of the offloading demand to the party; receive, from each of a plurality of providers of access to the alternative network, a reserve price for access to one or more access points in the alternative network that are provided by the provider, wherein the reserve price is a minimum price that must be met on average across all of the one or more access points provided by that provider; and, for each of one or more sectors and each of one or more time slots, allocate at least one access point in the alternative network, in the sector and for the time slot, to at least one of the one or more parties based on the received values of the offloading demands and the received reserve prices, and, during the time slot, offload one or more mobile devices, that are communicatively connected to a primary network of the at least one party within the sector, to the allocated at least one access point in the alternative network.", "15.A system comprising: at least one hardware processor; and one or more software modules configured to, when executed by the at least one hardware processor, receive, from each of one or more parties, an offloading demand for access to an alternative network and a value of the offloading demand to the party, receive, from each of a plurality of providers of access to the alternative network, a reserve price for access to one or more access points in the alternative network that are provided by the provider, wherein the reserve price is a minimum price that must be met on average across all of the one or more access points provided by that provider, and, for each of one or more sectors and each of one or more time slots, allocate at least one access point in the alternative network, in the sector and for the time slot, to at least one of the one or more parties based on the received values of the offloading demands and the received reserve prices, and, during the time slot, offload one or more mobile devices, that are communicatively connected to a primary network of the at least one party within the sector, to the allocated at least one access point in the alternative network." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>Aspects and features of the present inventive concept will be more apparent by describing example embodiments with reference to the accompanying drawings, in which: FIG.", "1 is a block diagram illustrating a cellular network and an alternative access network according to various embodiments; and FIG.", "2 is a graph illustrating a typical variation of data usage during the hours of a business day in a downtown business district and an example of such peak demand exceeding the cellular network capacity; and FIG.", "3 is a flowchart illustrating a method according to various embodiments.", "detailed-description description=\"Detailed Description\" end=\"lead\"?" ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "15/691,566, filed on Aug. 30, 2017, which is a continuation of U.S. patent application Ser.", "No.", "14/587,662, filed on Dec. 31, 2014, which claims the benefit of U.S.", "Provisional Patent App.", "No.", "61/922,396, filed on Dec. 31, 2013, U.S.", "Provisional Patent App.", "No.", "61/922,382, filed on Dec. 31, 2013, and U.S.", "Provisional Patent App.", "No.", "61/922,376, filed on Dec. 31, 2013, the disclosures of all of which are hereby incorporated herein by reference as if set forth in their entireties.", "BACKGROUND Field The subject matter discussed herein relates generally to wireless service to mobile devices and, more particularly, to allocation of resources on alternative radio access networks that can be used to service mobile devices in situations in which the alternative network access providers wish to set minimum acceptable prices for network access.", "Introduction Mobile devices generally rely on wireless service provided by a service provider using cellular communications that utilize radio frequency communication.", "Data communications to mobile devices can also be provided over other types of radio access networks.", "For example, Wi-Fi access points connected to broadband networks provide data to mobile devices.", "The choice of whether data communication takes place over a cellular network or a Wi-Fi connection is normally left to the end user of the device.", "If the end user has entered all necessary passwords and access credentials to the mobile device memory and the Wi-Fi radio is on, in many cases the connection to Wi-Fi is preferred automatically by the mobile device.", "In U.S. patent application Ser.", "No.", "13/684,044 (filed Nov. 21, 2012), Ser.", "No.", "13/684,048 (filed Nov. 21, 2012), Ser.", "No.", "13/684,049 (filed Nov. 21, 2012), 61/805,473 (filed Mar.", "26, 2012), 61/805,476 (filed Mar.", "26, 2012) and 61/877,178 (filed Sep. 12, 2013) methods are described for alternative network access (ANA) based on methods and systems for selecting the radio access network to provide Internet or other network access based on terms and conditions for allowing access and terms and conditions for utilizing access to the alternative network.", "Each of those applications is hereby incorporated by reference in their entirety.", "In practice, the terms and conditions for utilizing access to alternative networks often depend on the expected or the actual load on the primary network managed by the service provider for the device.", "For example, if the primary network access takes place through the cellular network system owned by the service provider for the device, it is likely that the service provider first wants to utilize all of the capacity in its own network before seeking to use capacity from an alternative network.", "This is especially the case if there is a cost associated with using the alternative network access.", "In provisional patent application titled SYSTEMS AND METHODS FOR MANAGING OFFLOAD FROM ONE RADIO ACCESS NETWORK TO ANOTHER filed concurrently herewith, systems and methods are described to manage offload of traffic to a system of alternative network access points based on and offload profile established by mutual agreement between the primary mobile network operator and the provider of alternative network access.", "That application is incorporated herein by reference in its entirety.", "In provisional patent application titled SYSTEMS AND METHODS FOR ALLOCATING ALTERNATIVE NETWORK ACCESS RESOURCES filed concurrently herewith, a method is described to allocate access to access points for alternative network access when several mobile operators and alternative access providers are involved.", "That application is incorporated herein by reference in its entirety.", "This application describes a methodology for utilizing reserve prices for allocating and pricing access to resources represented by the access points of the alternative network access provider or several providers in a situation where one or more mobile network operators and zero or more other parties interested in access to the same resources through the same access management system and the alternative network access providers wish to set a minimum price for their resources.", "BRIEF DESCRIPTION OF THE DRAWINGS Aspects and features of the present inventive concept will be more apparent by describing example embodiments with reference to the accompanying drawings, in which: FIG.", "1 is a block diagram illustrating a cellular network and an alternative access network according to various embodiments; and FIG.", "2 is a graph illustrating a typical variation of data usage during the hours of a business day in a downtown business district and an example of such peak demand exceeding the cellular network capacity; and FIG.", "3 is a flowchart illustrating a method according to various embodiments.", "DETAILED DESCRIPTION The subject matter described herein is taught by way of example implementations.", "Various details have been omitted for the sake of clarity and to avoid obscuring the subject matter.", "The examples shown below are directed to structures and functions for implementing systems and methods for establishing wireless connections based on access conditions.", "Other features and advantages of the subject matter should be apparent from the following description.", "As communication needs of various wireless and mobile devices have grown, many of them have been equipped with more than one radio system.", "Each of the radio systems may be used to connect to one or more wireless networks based on the system protocols.", "Examples of such systems are a cellular radio system that may be utilizing a GSM, CDMA or the LTE standard for encoding the signal and a Wi-Fi system that utilizes a well-known IEEE 802.11 standard for communication.", "Another example would be a WiMAX system that is based on the IEEE standard 802.16.FIG.", "1 is a block diagram 100 illustrating a cellular network and an alternative access network according to various embodiments.", "Referring to FIG.", "1, a mobile device 110 may communicate with a cellular network 120.The mobile device 110 may also be configured to communicate with an alternative access network 140 through an access point 130.In a communication device that has multiple radio systems each of the radios may have different characteristics.", "For example, the cellular system may be designed to connect to cell towers that are further apart and use a higher power signal than the Wi-Fi radio system uses.", "Since the Wi-Fi standard is utilizing unlicensed spectrum, the power of the transmitter may be limited by regulation and consequently the distance over which the communication can effectively take place in is typically shorter than the distance in the case of a cellular connection.", "The different characteristic of the radio systems result in a topology of coverage in the environment that is very different for each radio access network.", "For example, in the cellular system a single radio may be covering an area ranging from hundreds of meters across to a few kilometers, with typically one square kilometer or more of surface area for a cellular sector.", "In comparison, a Wi-Fi system that is based on using unlicensed radio bands and therefore limited in the power of the signal, typically only covers an area of 50 meters to 100 meters across.", "The end result of the relatively high penetration of broadband access, high prevalence of Wi-Fi access points as the termination points on broadband connections and the sparse and intermittent use of these Internet connections is that there is tremendous unused wireless network access capacity available in most urban and suburban areas.", "This capacity is owned and controlled by broadband service providers.", "In most cases these are different companies than the mobile network operators.", "Therefore in most cases the access points are not available for alternative network access to the mobile devices that primarily use cellular networks for accessing the Internet.", "As the overall usage of data by mobile devices continues to grow, more devices, connected to a particular cell sector radio will attempt to use more data at higher frequencies.", "Over time this means that the maximum capacity of data traffic at the cellular radio will be reached.", "Initially this typically happens only during peak usage times.", "These peak times are typically very regular and occur during business days during the same hours every day.", "The actual pattern of usage may be different at different locations.", "For example, in downtown business districts the peak usage takes place during the morning and evening commute hours and during lunchtime.", "In suburban residential areas the highest usage normally occurs during the evening hours.", "FIG.", "2 is a graph illustrating a typical variation of data usage during the hours of a business day in a downtown business district and an example of such peak demand exceeding the cellular network capacity.", "Since the mobile network operators occasionally in some locations need additional capacity and broadband network operators with Wi-Fi access to the network often have capacity that is not being used, it makes sense for the broadband network operators to become providers of alternative network access to the mobile network operators.", "However, allocating the resources of these alternative network access points to possibly several mobile network operators that may wish to use them at the same time is not a trivial problem.", "A method of using mixed integer programming to allocate access based on values provided by the buyers of access, mobile network operators (MNOs), mobile virtual network operators (MVNOs) and other parties interested in access to the alternative networks was explained in patent application titled SYSTEMS AND METHODS FOR ALLOCATING ALTERNATIVE NETWORK ACCESS RESOURCES.", "The basic assumption in that method was that access to the alternative network access points was available regardless of what the values stated by the MNOs and other parties interested in the access were.", "This application provides the solution for how to allocate the access (in the form of reservations) in case the various alternative access providers have established minimum prices for getting access to other resources, and how to compute prices for these reservations.", "In the following the minimum price for capacity from a particular access point is called the reserve price.", "The reserve price can either be set individually for each access point and can be dependent on the time, or a seller can specify one “averaged” reserve price that needs to be met on average, but not at every access point at in each time slot.", "In the following example the allocation is done once a day for one hour time slots during a day.", "Obviously the same mechanism applies for any other frequency for allocating capacity and any other time resolution.", "Reservation Mechanism Using Reserve Prices In order to understand the constrains and allocation mechanism the following are the indices used in the equations that express the constraints: Sets and Indices: iϵI, indexing MNOs, and iϵI′, indexing MVNOs jϵJ, indexing the sectors (individually per MNO/MVNO) sϵS, indexing sellers aϵA, indexing APs kϵK={0, 1, .", ".", ".", "23}, time slots in a day The following are the parameters and their units: Parameters [Units]: Dijk [Mbits/s], offloading demand from MNO/MVNO i in sector j for slot k; D ij = ∑ k ∈ K   D ijk Sak [Mbits/s], (predicted) supply available at access point a in time slot k T ijak  [ Mbits s ] , (Predicted) traffic from MNO/MVNO i in j “around” AP a in timeslot k (offloading potential) Fijk [Mbits/s], capacity downwards tolerance (“fudge factor)” by MNO i in its sector j in time slot k Vij [$], value of MNO i for sector j for offloading all of its demand during the whole day in this sector Vi′ [$/GB], value of MVNO i for offloading 1 GB (in any sector at any time) Rak [$/Mbits], reserve price from access point a for time slot k Rs [$/Mbits], “average” reserve price from seller s for all of its APs and all time slots BijakT ϵ[0, 1], volatility buffer to “discount” the traffic from i in sector j in timeslot k around AP a BakSϵ[0, 1], volatility buffer to “discount” the supply from access point a in timeslot turn italic Cϵ[0, 1], commission (multiplied with clearing price, e.g., C=0.1) L [seconds], length of one time slot (e.g., 3,600 seconds=1 hour) The variables in the system and their units are: Variables [Units] xij ϵ{0,1}, does MNO i get reservation for sector j or not (modeling the combinatorial preferences) yijk [Mbits/s], traffic reservation for MNO/MVNO i for sector j in time slot k rijak [Mbits/s], traffic reservation at access point a for MNO/MVNO is sector j in time slot k rijak [Mbits/s], traffic reservation for MNO/MVNO is sector j in time slot k at all of seller s's APs The mixed integer programming MIP expression to be maximized is: max x , y , r  ∑ i ∈ I   ∑ j ∈ J   V ij · ∑ k ∈ K   y ijk D ij ·  value   created   from   MNOs + ∑ i ∈ I ′   ∑ j ∈ J  ∑ k ∈ K  V i ′ · y ijk · L 8 · 1  ,  000  value   created   from   MVNOs ( MIP   1 ) The associated constraints are: yijk≤xij·Dijk∀iϵI, jϵJ, kϵK [only reserve sth, if allocated, and never more than demand] (2) yijk≥xij·(Dijk−Fijk)∀iϵI, jϵJ, kϵK [if allocated, then don't reserve too little] (3) yijk=Σarijak∀iϵI∪I′, jϵJ, kϵK [reserve as much as needed to satisfy demand] (4) rijak≤Tijak·BijakT∀iϵI∪I′,j,k,a [don't reserve more than available traffic around AP] (5) Σi,jrijak≤Sak·BakS∀aϵA, kϵK [don't reserve more at an AP than available supply] (6) V ij · ∑ k ∈ K   y ijk D ij ≥ ∑ a ∈ A   ∑ k ∈ K  R ak ( 1 - C ) · r ijak · L 8 · 1000  ∀ i ∈ I , j ∈ J   [ MNOs  :   handle   per  -  Ap  -  per  -  k   reserves ] ( 7 ) V i ′ · y ijk · L 8 · 1000 ≥ ∑ a ∈ A  R ak ( 1 - C ) · r ijak · L 8 · 1000  ∀ i ∈ I ′ , j ∈ J , k ∈ K   [ MVNO  :   handle   per  -  Ap  -  per  -  k   reserves ] ( 8 ) V ij · ∑ k ∈ K   y ijk D ij ≥ ∑ s ∈ S  R s ( 1 - C ) · ∑ k ∈ K  r ijsk · L 8 · 1000  ∀ i ∈ I , j ∈ J   [ MNO  :   handle   average   reserve   prices ] ( 9 ) V i ′ · y ijk · L 8 · 1000 ≥ ∑ s ∈ S  R ak ( 1 - C ) · r ijsk · L 8 · 1000  ∀ i ∈ I ′ , j ∈ J , k ∈ K   [ MVNO  :   handle   average   reserves ] ( 10 ) rijsk=ΣaϵA(s)rijak∀iϵI∪I′, jϵJ, sϵS, kϵK [set the reservation variables consistently] (11) The objective function: we maximize efficiency (i.e., social welfare), i.e., we maximize the total value created.", "Because MNOs and MVNOs report their value functions differently, we should treat them separately.", "In the first term, we sum over all MNOs i and all of their sectors j, and for each sector, we multiply their reported value Vij (in $) with the fraction of how much of their total demand they actually received (thus assuming a linear value relationship).", "In the second term, we sum over all MVNOs i, all their sectors j and all time slots k, and then multiply their value (in dollars per GB ($/GB)) with how much bandwidth they actually received (in GB).", "We multiply by L and divide by 8 and 1,000 to convert MBit/s into GB.", "The explanations for the constraints are the following: Line (2): This and the following constraint handle the combinatorial preferences for the MNOs.", "Here, if MNO i does not get a reservation in sector j, then xijk=0, and thus, the amount of traffic reserved yijk must also be 0.If i gets the reservation in sector j, then xijk=1, and then we make sure that we do not reserve more than the demand, i.e., yijk≤Dijk.", "Line (3): This line handles the second part of the combinatorial constraint.", "If MNO i gets a reservation for sector j (i.e., xij=1), then we must reserve enough, i.e., at least its demand minus the maximal allowable capacity deviation, i.e., yijk≥Dijk−Fijk.", "Line (4): This constraint balances demand and supply.", "Every reservation that we promise some buyer (i.e., yijk) needs to be satisfied by the reservations made for this buyer at all APs (i.e., Σa rijak).", "Line (5): This constraint makes sure we obey the traffic potential around the APs.", "Specifically, for every buyer i and its sector j for every timeslot k and every AP a, we cannot reserve more than there is potential traffic to be offloaded.", "On the right-hand-side, we multiply Tijak, i.e., the potential traffic to be offloaded, with the volatility buffer BijakT ϵ[0,1] to account for the volatility of the traffic around the AP.", "If there is low volatility, then we will have a high value for BijakT close to 1.Line (6): This constraint makes sure we obey the availability supply at each AP.", "More specifically, for each AP a and timeslot k, we make sure that the total amount of reservations for this AP and timeslot (i.e., Σi,jrijak) is less than or equal to the available supply.", "To get the available supply, we multiply (i.e., reduce, the supply parameter Sak with the volatility buffer BakTϵ[0,1] to account for the volatility in supply at this AP in timeslot k (particularly important for amenity Wi-Fi).", "Line (7): The next two constraints handle the per-Access Point-per-time-slot reservation prices of the sellers.", "This specific constraint handles this for the MNOs.", "For each MNO i and each sector j, we make sure that the total value generated (i.e., the expression on the left-and-side) is at least as large as necessary to satisfy the reservation prices and the commission (i.e., the expression on the right-hand-side).", "You can verify that the expression on the left-hand-side is the same as the value of the MNOs in the objective of the function (i.e.", "a term measured in dollars).", "On the right-hand-side, we sum over all APs and time slots, and then take each per-AP-per-time-slot reservation price Rak and divide it by (1−C) to account for the commission.", "For example, if the reservation price is $9, and C=0.1, then the resulting term is $10, i.e., effectively, we have increased the reservation price, because the $10 is the true minimum clearing price possible, such that we can still take a 10% commission and still have enough left to satisfy the seller's true reservation price (of $9).", "Once we have this “corrected” reservation price (in $/GB) we multiply it with the total amount of traffic reserved at this AP for this time slot.", "Because rijak is measured in Mbits/s, we multiply it by L=3, 600 seconds, and divide by 8 and by 1,000 to get the total traffic in GB.", "This, multiplied by the reserve price (in $/GB), gives us a value measured in dollars as on the left-hand-side.", "Line (8): This line handles the per-AP-per-time-slot reservation price constraint for the MVNOs.", "Again, the term on the left-hand-side is the realized value of the MVNO, and you can verify that it is the same expression as in the second term in the objective function.", "On the right-hand side, we have the same expression as in the line above, except that we do not sum over all time slots k, but instead we have a separate constraint individually for each time slot, because MVNOs do not have combinatorial preferences that span multiple time slots.", "Line (9): The next two lines handle the “average” reservation prices of the sellers, i.e., the reservation prices do not need to hold per AP, or per buyer or per sector, but just on average over all the seller's APs.", "This line specifically handles this for the MNOs only.", "Still, the decision is whether to make a reservation for a buyer i in sector j or not.", "Thus, for each i and each j, we check, if the reservation-price constraint can be satisfied, i.e., we make sure that the value generated for this buyer in this sector is enough to satisfy the reservation prices in the commission (otherwise we cannot make a reservation for this buyer in this sector).", "On the left-hand-side, as before, we simply have the value generated for the buyer, the same as in the first term in the objective function.", "On the right-hand-side, we now sum over all sellers s E S, and for each seller, we defied its reservation price Rs by (1−C) to account for the commission, as before.", "Then we multiply this “corrected” reservation price with the total amount of bandwidth reserved at an access point that belongs to the seller.", "For this, we introduce the new variable rijsk which denotes the sum of the reservations for buyer i in sector j at all access points belonging to seller s. See line (11) where these variables are set.", "Line (10): This line handles the “average” reservation prices for the MVNOs.", "As before, the left-hand-side is the value generated for the MVNOs, and it is the same as the second term in the objective function.", "The right-hand-side is the same as in the line above, except that we do not sum over all time slots k E K, because the MVNOs do not have combinatorial constraints that span multiple timeslots.", "For this reason, we instead have a separate constraint for every timeslot, because it is okay if the constraints only hold individually, per timeslot.", "Line (11): In this line we set the new reservation variables rijsk that capture how much bandwidth we reserve at any of seller s's access points for a buyer i in sector j for time slot k, to be equal to the sum of the per-AP-reservations rijak.", "For this, we need to sum over all APs in the set A(s), i.e., the set of all access points that belong to seller s. Pricing Mechanism for Short-Term Market For the short-term market, we also use MIP 1 to compute the reservations.", "The only difference is that now the MNOs do not have combinatorial preferences.", "However, the result of solving MIP 1 is still a set of reservations.", "To price the reservations of the short-term market, we will use the VCG (Vickrey-Clarke-Groves) mechanism.", "In particular, we will compute one price per buyer per day to be paid to the market operator.", "The algorithmic process of computing the VCG prices per buyer involves solving the MIP 1 once including all buyers, and then again n more times, where n corresponds to the number of winning buyers.", "The payment of buyer i is then the difference in value accrued to all others buyers in the solution that includes buyer i and their value in the solution that does not include buyer i.", "We subtract the commission fee from the buyer's VCG payment, and the remaining amount of money is paid to the sellers who owned any of the access points via which the buyer offloaded some of its data.", "The amount of money is split up accordingly to the contribution each seller made (i.e., the amount of traffic from this buyer that went through its AP relative to the total amount of traffic).", "Pricing Mechanism for Long-Term Market To price the reservations that result from solving MIP 1, we use core-selecting combinatorial auctions with reserve prices.", "That means that we compute one price for each buyer, and the prices lie in the so-called “core” which means that none of the losing bidders would be willing to pay more for the resources than what the winning bidders are paying.", "We will use the VCG payment vector (computed as described above) as the reference price vector in computing core payments, and we will minimize the Euclidian distance to the VCG price vector to determine the final payments.", "Based on the buyers' payments, the commission fee and the payments to the sellers are calculated in the same way as described in the short-term market design.", "To make the computation of the core payments computationally feasible, we will use a core constraint generation method, which iteratively adds new core constraints to the price finding algorithm until no more core constraints are violated, i.e., until prices are high enough such that all prices are in the core.", "FIG.", "3 is a flowchart illustrating a method according to various embodiments.", "Referring to FIG.", "3, one or more parties may input needs for alternative network access and representative values for satisfying the needs (310).", "The parties may receive from providers of alternative network access reserve prices for access to each access point in the alternative network (320).", "A solution based on a mixed integer program may be generated to maximize value created by allocation of alternative network access (330).", "Alternative network access may be allocated to the one or more parties based on the mixed integer program solution (340).", "The foregoing systems and methods and associated devices and modules are susceptible to many variations.", "Additionally, for clarity and concision, many descriptions of the systems and methods have been simplified.", "For example, the figures generally illustrate one of each type of network device, but a network system may have many of each type of device.", "As described in this specification, various systems and methods are described as working to optimize particular parameters, functions, or operations.", "This use of the term optimize does not necessarily mean optimize in an abstract theoretical or global sense.", "Rather, the systems and methods may work to improve performance using algorithms that are expected to improve performance in at least many common cases.", "For example, the systems and methods may work to optimize performance judged by particular functions or criteria.", "Similar terms like minimize or maximize are used in a like manner.", "Those of skill will appreciate that the various illustrative logical blocks, modules, units, and algorithm steps described in connection with the embodiments disclosed herein can often be implemented as electronic hardware, computer software, or combinations of both.", "To clearly illustrate this interchangeability of hardware and software, various illustrative components, blocks, modules, and steps have been described above generally in terms of their functionality.", "Whether such functionality is implemented as hardware or software depends upon the particular constraints imposed on the overall system.", "Skilled persons can implement the described functionality in varying ways for each particular system, but such implementation decisions should not be interpreted as causing a departure from the scope of the invention.", "In addition, the grouping of functions within a unit, module, block, or step is for ease of description.", "Specific functions or steps can be moved from one unit, module, or block without departing from the invention.", "The various illustrative logical blocks, units, steps and modules described in connection with the embodiments disclosed herein can be implemented or performed with a processor, such as a general purpose processor, a multi-core processor, a digital signal processor (DSP), an application specific integrated circuit (ASIC), a field programmable gate array (FPGA) or other programmable logic device, discrete gate or transistor logic, discrete hardware components, or any combination thereof designed to perform the functions described herein.", "A general-purpose processor can be a microprocessor, but in the alternative, the processor can be any processor, controller, microcontroller, or state machine.", "A processor can also be implemented as a combination of computing devices, for example, a combination of a DSP and a microprocessor, a plurality of microprocessors, one or more microprocessors in conjunction with a DSP core, or any other such configuration.", "The steps of a method or algorithm and the processes of a block or module described in connection with the embodiments disclosed herein can be embodied directly in hardware, in a software module executed by a processor, or in a combination of the two.", "A software module can reside in RAM memory, flash memory, ROM memory, EPROM memory, EEPROM memory, registers, hard disk, a removable disk, a CD-ROM, or any other form of storage medium.", "An exemplary storage medium can be coupled to the processor such that the processor can read information from, and write information to, the storage medium.", "In the alternative, the storage medium can be integral to the processor.", "The processor and the storage medium can reside in an ASIC.", "Additionally, device, blocks, or modules that are described as coupled may be coupled via intermediary device, blocks, or modules.", "Similarly, a first device may be described a transmitting data to (or receiving from) a second device when there are intermediary devices that couple the first and second device and also when the first device is unaware of the ultimate destination of the data.", "The above description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the invention.", "Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles described herein can be applied to other embodiments without departing from the spirit or scope of the invention.", "Thus, it is to be understood that the description and drawings presented herein represent a presently preferred embodiment of the invention and are therefore representative of the subject matter that is broadly contemplated by the present invention.", "It is further understood that the scope of the present invention fully encompasses other embodiments that may become obvious to those skilled in the art." ] ]
Patent_15872878
[ [ "THIN FILM TRANSISTOR AND METHOD FOR MANUFACTURING THIN FILM TRANSISTOR", "A thin film transistor includes a gate electrode.", "The thin film transistor further includes an oxide semiconductor layer which includes at least indium and is usable as a channel layer, wherein a region of the oxide semiconductor layer closest to the gate electrode includes fluorine.", "The thin film transistor further includes a gate insulating layer between the gate electrode and the oxide semiconductor layer.", "The thin film transistor further includes a fluorine-including layer which includes fluorine and is between the gate electrode and the gate insulating layer." ], [ "1.A thin film transistor comprising: a gate electrode; an oxide semiconductor layer which includes at least indium and is usable as a channel layer, wherein a region of the oxide semiconductor layer closest to the gate electrode includes fluorine; a gate insulating layer between the gate electrode and the oxide semiconductor layer; and a fluorine-including layer which includes fluorine and is between the gate electrode and the gate insulating layer.", "2.The thin film transistor according to claim 1, wherein the gate insulating layer includes fluorine, and a fluorine concentration of the oxide semiconductor layer is higher than a fluorine concentration of the gate insulating layer.", "3.The thin film transistor according to claim 1, wherein the fluorine-including layer is a fluorine layer consisting of fluorine.", "4.The thin film transistor according to claim 1, wherein the gate insulating layer comprises an inorganic material, and the fluorine-including layer comprises an organic material and fluorine.", "5.The thin film transistor according to claim 1, wherein the fluorine-including layer and the gate insulating layer include a same material, and a peak position of an X-ray photoelectron spectroscopy spectrum of the material in the fluorine-including layer is closer to a high binding energy side than a peak position of an X-ray photoelectron spectroscopy spectrum of the material in the gate insulating layer.", "6.The thin film transistor according to claim 1, wherein in the oxide semiconductor layer, a fluorine concentration of a region closest to the gate insulating layer is higher than a fluorine concentration of a region farthest from the gate insulating layer.", "7.A method for manufacturing a thin film transistor, the method comprising: forming an oxide semiconductor film including indium, above a substrate; forming a gate insulating layer above the oxide semiconductor film; forming a fluorine-including layer above the gate insulating layer; forming a gate electrode above the fluorine-including layer; and annealing the fluorine-including layer to diffuse fluorine from the fluorine-including layer into the oxide semiconductor film.", "8.The method according to claim 7, wherein in the forming of the gate insulating layer, the gate insulating layer which includes component material is deposited on the oxide semiconductor film by supplying reactive gas containing molecules including an alkyl group and the material included in the gate insulating layer.", "9.The method according to claim 8, wherein the forming of the fluorine-including layer comprises forming the fluorine-including layer above a portion of the oxide semiconductor film, and the annealing comprises diffusing fluorine into the portion of the oxide semiconductor film, and the diffused fluorine bonds with the oxide semiconductor film, the portion of the oxide semiconductor film covered with the fluorine-including layer includes in a region of the oxide semiconductor film from which the reactive gas, supplied when the gate insulating layer is deposited, desorbs oxygen.", "10.A display comprising: a substrate; an oxide semiconductor layer over the substrate, wherein the oxide semiconductor layer comprises indium, the oxide semiconductor layer is usable has a channel layer, and a region of the oxide semiconductor layer farthest from the substrate includes fluorine; a gate insulating layer over the oxide semiconductor layer; a fluorine-including layer over the gate insulating layer; and a gate electrode over the fluorine-including layer.", "11.The display according to claim 10, further comprising: a source region on a first side of the oxide semiconductor layer; and a drain region on a second side of the oxide semiconductor layer, wherein the first side is opposite the second side.", "12.The display according to claim 11, wherein the gate insulating layer is a continuous layer extending over the oxide semiconductor layer, the source region and the drain region.", "13.The display according to claim 11, wherein the fluorine-including layer is limited to an area of the gate insulating layer directly above the oxide semiconductor layer.", "14.The display according to claim 11, further comprising an interlayer insulating layer over the gate insulating layer.", "15.The display according to claim 14, further comprising: a source electrode extending through the interlayer insulating layer and the gate insulating layer to electrically connect with the source region; and a drain electrode extending through the interlayer insulating layer and the gate insulating layer to electrically connect with the drain region.", "16.The display according to claim 10, further comprising an undercoat layer between the oxide semiconductor layer and the substrate.", "17.The display according to claim 10, further comprising an organic EL element over the gate electrode.", "18.The display according to claim 17, wherein the organic EL element comprises: an anode; a cathode; and a light emitting layer between the anode and the cathode.", "19.The display according to claim 17, further comprising: a source region on a first side of the oxide semiconductor layer, wherein the source region is electrically connected to the organic EL element.", "20.The display according to claim 19, wherein the source region directly contacts a sidewall of the oxide semiconductor layer." ], [ "<SOH> BACKGROUND ART <EOH>Active matrix display devices such as liquid crystal display devices and organic electroluminescent (EL) display devices use TFTs as switching elements or driver elements.", "In recent years, active development has been conducted on, as next-generation TFTs, oxide semiconductor TFTs which use an oxide semiconductor such as InGaZnO x (IGZO) for channel layers.", "For example, Patent Literature (PTL) 1 describes an oxide semiconductor TFT having an oxide semiconductor layer as a channel layer." ], [ "<SOH> SUMMARY <EOH>Producing an oxide semiconductor TFT having high reliability is difficult.", "The present description helps to provide a thin film transistor having high reliability and a method for manufacturing the thin film transistor.", "In order to provide a thin film transistor (TFT) having high reliability, a thin film transistor according to one aspect of the present description includes a gate electrode.", "The TFT further includes an oxide semiconductor layer which includes at least indium and is usable as a channel layer.", "The TFT further includes a gate insulating layer disposed between the gate electrode and the oxide semiconductor layer.", "The TFT further includes a fluorine-including layer which includes fluorine and is disposed between the gate electrode and the gate insulating layer.", "Fluorine is included in a region in the oxide semiconductor layer and close to the gate insulating layer.", "A thin film transistor having the above structure exhibits high reliability." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS The present application is a continuation of International Application No.", "PCT/JP2015/003610 filed Jul.", "17, 2015 which designates the United States, incorporated herein by reference.", "TECHNICAL FIELD The present description relates to a thin film transistor (TFT) and a method for manufacturing the thin film transistor, and in particular to an oxide semiconductor thin film transistor having an oxide semiconductor layer, and a method for manufacturing the oxide semiconductor thin film transistor.", "BACKGROUND ART Active matrix display devices such as liquid crystal display devices and organic electroluminescent (EL) display devices use TFTs as switching elements or driver elements.", "In recent years, active development has been conducted on, as next-generation TFTs, oxide semiconductor TFTs which use an oxide semiconductor such as InGaZnOx (IGZO) for channel layers.", "For example, Patent Literature (PTL) 1 describes an oxide semiconductor TFT having an oxide semiconductor layer as a channel layer.", "CITATION LIST Patent Literature [PTL 1] Japanese Unexamined Patent Application Publication No.", "2010-161227 [PTL 2] Japanese Unexamined Patent Application Publication No.", "2007-220817 Non Patent Literature [NPL 1] J.", "Park, et.", "al., “Self-aligned top-gate amorphous gallium indium zinc oxide thin film transistors,” Applied Physics Letters, American Institute of Physics, 93, 053501 (2008) [NPL 2] Hideyuki Omura, et.", "al., “First-principles study of native point defects in crystalline indium gallium zinc oxide,” J. Appl.", "Phys.", "105, 093712, 2009 SUMMARY Producing an oxide semiconductor TFT having high reliability is difficult.", "The present description helps to provide a thin film transistor having high reliability and a method for manufacturing the thin film transistor.", "In order to provide a thin film transistor (TFT) having high reliability, a thin film transistor according to one aspect of the present description includes a gate electrode.", "The TFT further includes an oxide semiconductor layer which includes at least indium and is usable as a channel layer.", "The TFT further includes a gate insulating layer disposed between the gate electrode and the oxide semiconductor layer.", "The TFT further includes a fluorine-including layer which includes fluorine and is disposed between the gate electrode and the gate insulating layer.", "Fluorine is included in a region in the oxide semiconductor layer and close to the gate insulating layer.", "A thin film transistor having the above structure exhibits high reliability.", "BRIEF DESCRIPTION OF DRAWINGS FIG.", "1 is a cross-sectional view of a structure of a thin film transistor according to at least one embodiment.", "FIG.", "2A is a cross-sectional view of a process for preparing a substrate in a method for manufacturing the thin film transistor according to at least one embodiment.", "FIG.", "2B is a cross-sectional view of a process for forming an undercoat in the method for manufacturing the thin film transistor according to at least one embodiment.", "FIG.", "2C is a cross-sectional view of a process for depositing an oxide semiconductor film in the method for manufacturing the thin film transistor according to at least one embodiment.", "FIG.", "2D is a cross-sectional view of a process for forming a gate insulating layer in the method for manufacturing the thin film transistor according to at least one embodiment.", "FIG.", "2E is a cross-sectional view of a process for forming a fluorine-including layer in the method for manufacturing the thin film transistor according to at least one embodiment.", "FIG.", "2F is a cross-sectional view of a process for annealing in the method for manufacturing the thin film transistor according to at least one embodiment.", "FIG.", "2G is a cross-sectional of illustrating a process for forming a gate electrode in the method for manufacturing the thin film transistor according to at least one embodiment.", "FIG.", "2H is a cross-sectional view of a process for forming an interlayer insulating layer in the method for manufacturing the thin film transistor according to at least one embodiment.", "FIG.", "2I is a cross-sectional view of a process for forming a source electrode and a drain electrode in the method for manufacturing the thin film transistor according to at least one embodiment.", "FIGS.", "3A-B are diagrams of depositing a gate insulating layer on an oxide semiconductor film by plasma chemical vapor deposition (CVD) according to at least one embodiment.", "FIGS.", "4A-C are diagrams of details for annealing in FIG.", "2F according to at least one embodiment.", "FIG.", "5 is a graph of results of measuring a sheet resistance value in the case where fluorine is included in an oxide semiconductor layer, and a sheet resistance value in the case where fluorine is not included in the oxide semiconductor layer according to at least one embodiment.", "FIG.", "6 is a cross-sectional view of a device structure of a sample used in an experiment for hydrogen resistance according to at least one embodiment.", "FIG.", "7 is a graph, for the sample having the structure illustrated in FIG.", "6, of μ-PCD peak intensity and a resistance value of the oxide semiconductor layer when a film thickness of a silicon oxide layer is varied according to at least one embodiment.", "FIG.", "8 is a graph of results of comparing μ-PCD peak intensity and the presence or absence of fluorine introduction to an oxide semiconductor layer according to at least one embodiment.", "FIG.", "9A is a graph of an In3d5 XPS spectrum in the case where fluorine is included in an oxide semiconductor layer, and an In3d5 XPS spectrum in the case where fluorine is not included in the oxide semiconductor layer according to at least one embodiment.", "FIG.", "9B is a graph of a Zn2p3 XPS spectrum in the case where fluorine is included in an oxide semiconductor layer, and a Zn2p3 XPS spectrum in the case where fluorine is not included in the oxide semiconductor layer according to at least one embodiment.", "FIG.", "9C is a graph of a Ga2p3 XPS spectrum in the case where fluorine is included in an oxide semiconductor layer, and a Ga2p3 XPS spectrum in the case where fluorine is not included in the oxide semiconductor layer according to at least one embodiment.", "FIG.", "10 is a graph of a Zn thermal desorption spectrum by TDS in the case where fluorine is included in an oxide semiconductor layer, and a Zn thermal desorption spectrum by TDS in the case where fluorine is not included in the oxide semiconductor layer according to at least one embodiment.", "FIG.", "11 is a graph of resistance values of an oxide semiconductor film in the case where ALD is used and in the case where ALD is not used according to at least one embodiment.", "FIG.", "12 is a cutaway perspective view of part of an organic EL display device according to at least one embodiment.", "FIG.", "13 is an electric circuit diagram of a pixel circuit of the organic EL display device in FIG.", "12 according to at least one embodiment.", "DETAILED DESCRIPTION A thin film transistor (TFT) according to at least one aspect of the present description includes a gate electrode.", "The TFT includes an oxide semiconductor layer which includes at least indium and is usable as a channel layer.", "The TFT includes a gate insulating layer disposed between the gate electrode and the oxide semiconductor layer.", "The TFT includes a fluorine-including layer which includes fluorine and is disposed between the gate electrode and the gate insulating layer.", "Fluorine is included in a region in the oxide semiconductor layer and close to the gate insulating layer.", "According to at least one aspect of the present description, fluorine is included in the region in the oxide semiconductor layer and close to the gate insulating layer.", "Fluorine has higher binding energy with metal than oxygen.", "Accordingly, including fluorine in the oxide semiconductor layer enables fluorine to help eliminate dangling bonds or an unstable site caused by oxygen deficiency in the oxide semiconductor layer.", "In other words, including fluorine in the oxide semiconductor layer makes helps to compensate for the oxygen deficiency in the oxide semiconductor layer.", "Moreover, including fluorine in the oxide semiconductor layer helps to prevent hydrogen entering the oxide semiconductor layer from bonding with the oxide semiconductor layer.", "With this, hydrogen is inhibited from entering the oxide semiconductor layer, thereby suppressing generation of charge carriers resulting from bonding of oxygen and hydrogen in the oxide semiconductor layer.", "In short, including fluorine in the oxide semiconductor layer helps to improve hydrogen resistance of the oxide semiconductor layer.", "Furthermore, including fluorine in the oxide semiconductor layer results in metallic elements included in the oxide semiconductor layer being chemically bonded with fluorine, which helps to stabilize a structure of the oxide semiconductor layer.", "As just described, according to at least one aspect of the present description, the oxide semiconductor layer is less susceptible to damage resulting hydrogen or oxygen as well as stabilize the structure of the oxide semiconductor layer.", "With this, a thin film transistor having high reliability and high robustness is possible.", "Moreover, according to at least one aspect of the present description, the fluorine-including layer is disposed between the gate electrode and the gate insulating layer.", "With this, a threshold voltage (Vth) of the thin film transistor is shifted to the positive side.", "Accordingly, the thin film transistor has superior device characteristics.", "Moreover, in the thin film transistor according to at least one aspect of the present description, the gate insulating layer includes fluorine, and a fluorine concentration of the oxide semiconductor layer is higher than a fluorine concentration of the gate insulating layer.", "According to at least one aspect of the present description, hydrogen entering the oxide semiconductor layer can be blocked by the oxide semiconductor layer.", "Moreover, in the thin film transistor according to at least one aspect of the present description, the fluorine-including layer may be a fluorine layer including only fluorine.", "According to at least one aspect of the present description, the fluorine-including layer is formed on the gate insulating layer by supply of fluorine system gas.", "Moreover, in the thin film transistor according to at least one aspect of the present description, the gate insulating layer may include an inorganic material, and the fluorine-including layer may be an organic layer which includes fluorine and includes an organic material.", "According to at least one aspect of the present description, the fluorine-including layer can be made of the organic layer including fluorine.", "With this, because the fluorine-including layer is physically adsorbed to the organic layer, fluorine is easily supplied to the oxide semiconductor layer from the fluorine-including layer.", "Moreover, in the thin film transistor according to at least one aspect of the present description, the fluorine-including layer and the gate insulating layer may include a same main element, and a peak position of an X-ray photoelectron spectroscopy spectrum of the main element in the fluorine-including layer may be closer to a high binding energy side than a peak position of an X-ray photoelectron spectroscopy spectrum of the main element in the gate insulating layer is.", "According to at least one aspect of the present description, fluorine in the fluorine-including layer is more chemically boned with the main element than fluorine in the gate insulating layer is.", "Moreover, in the thin film transistor according to at least one aspect of the present description, in the oxide semiconductor layer, a fluorine concentration of a region close to the gate insulating layer may be higher than a fluorine concentration of a region far from the gate insulating layer.", "According to at least one aspect of the present description, a portion of the region that is in the oxide semiconductor layer and close to the gate insulating layer (fluorine-including layer) is an oxygen deficient region, and only this region is compensated with fluorine.", "As a result, because an amount of fluorine is reduced, a high carrier density is maintained.", "Accordingly, the thin film transistor has superior ON characteristics.", "Moreover, a method for manufacturing a thin film transistor according to at least one aspect of the present description includes forming an oxide semiconductor film including indium, above a substrate.", "The method further includes forming a gate insulating layer above the oxide semiconductor film.", "The method further includes forming a fluorine-including layer above the gate insulating layer.", "The method further includes forming a gate electrode above the fluorine-including layer.", "The method further includes annealing, after the fluorine-including layer is formed, the fluorine-including layer to diffuse fluorine from the fluorine-including layer into the oxide semiconductor film.", "According to at least one aspect of the present description, oxygen deficiency in the oxide semiconductor film can be compensated with fluorine by diffusing fluorine from the fluorine-including layer into the oxide semiconductor film.", "This forms an oxide semiconductor layer which includes fluorine and in which the oxygen deficiency in the oxide semiconductor film is compensated for with the fluorine.", "As a result, the oxide semiconductor layer has superior hydrogen resistance as well as a stable structure.", "Accordingly, a thin film transistor having high reliability and high robustness is possible.", "Moreover, in the method for manufacturing a thin film transistor according to at least one aspect of the present description, in the forming of the gate insulating layer, the gate insulating layer which includes an element as a main component may be deposited on the oxide semiconductor film by supplying reactive gas containing molecules including an alkyl group and the element included in the gate insulating layer.", "According to at least one aspect of the present description, because the oxygen deficiency in a surface layer of the oxide semiconductor film is caused by oxygen being desorbed from the surface layer of the oxide semiconductor film by carbon of the alkyl group in the forming of the gate insulating layer, the oxide semiconductor film is in a low resistance state.", "In other words, low resistance regions (a source region and a drain region) are formed in the oxide semiconductor film without using plasma or hydrogen.", "Moreover, in the method for manufacturing a thin film transistor according to at least one one aspect of the present description, the fluorine-including layer may be formed above a portion of the oxide semiconductor film, and in the annealing, fluorine may be diffused into the portion of the oxide semiconductor film and bonded with the oxide semiconductor film, the portion being covered with the fluorine-including layer and included in a region of the oxide semiconductor film from which the reactive gas supplied when the gate insulating layer is deposited desorbs oxygen.", "According to at least one aspect of the present description, fluorine is diffused into the portion of the oxide semiconductor covered with the fluorine-including layer, whereas fluorine is not diffused into portions of the oxide semiconductor film not covered with the fluorine-including layer.", "In consequence, in the region (oxygen deficiency region) of the oxide semiconductor film from which oxygen is desorbed, the portion covered with the fluorine-including layer is compensated with fluorine, and the portions not covered with the fluorine-including layer are not compensated with fluorine and are kept in a low resistance state.", "Accordingly, by using the portion of the oxide semiconductor film compensated with fluorine as the channel region, and by using the portions of the oxide semiconductor film not compensated with fluorine as the source region and the drain region, a thin film transistor has the source region and the drain region on the respective sides of the channel region.", "In addition, the source region and the drain region are formed in a self-aligning manner.", "The following describes at least one embodiment of the present description with reference to the accompanying drawings.", "The at least one embodiment described below is merely an example of the present description.", "Values, shapes, materials, components, arrangement and connection of the components, processes (steps), order of the processes, and the like shown in the following embodiment are merely exemplary and are not intended to limit the present description.", "Therefore, among the components of the at least one embodiment below, components not recited in any one of independent claims are described as arbitrary components.", "The figures are schematic views and do not necessarily limit the present description to that precisely shown.", "In the figures, the same reference sign is used to refer to substantially the same component, and description already set forth is may be omitted or simplified.", "[Structure of Thin Film Transistor] First, the following describes a thin film transistor 1 according to at least one embodiment of the present description with reference to FIG.", "1.FIG.", "1 is a cross-sectional view of a structure of a thin film transistor according to at least one embodiment of the present description.", "In FIG.", "1, the thin film transistor 1 according to at least one embodiment is a top gate oxide semiconductor TFT having an oxide semiconductor layer as a channel layer.", "The thin film transistor 1 includes: a substrate 10; an undercoat layer 20; an oxide semiconductor layer 30 usable as a channel layer; an oxide semiconductor layer 40S usable as a source region; an oxide semiconductor layer 40D usable as a drain region; a gate insulating layer 50; a fluorine-including layer 60; a gate electrode 70; an interlayer insulating layer 80; and a source electrode 90S and a drain electrode 90D.", "The following describes in detail each component of the thin film transistor 1 according to at least one embodiment.", "The substrate 10 is a glass substrate including a glass material such as quartz glass, alkali-free glass, and high heat-resistant glass.", "The substrate 10 is not limited to the glass substrate and may be a resin substrate or the like.", "Moreover, the substrate 10 is not a rigid substrate but may be a flexible substrate including a single layer of a film material such as polyimide, polyethylene terephthalate, and polyethylene naphthalate, or stacked layers of these.", "The undercoat layer 20 is formed on the substrate 10.The undercoat layer 20 is formed to help prevent impurities such as sodium and phosphorus included in the substrate 10 (glass substrate) or moisture permeated from the air from entering the oxide semiconductor layers 30, 40S, and 40D.", "The undercoat layer 20 is a single layer insulating layer of an oxide insulating layer or a nitride insulating layer, or a stacked insulating layer including an oxide insulating layer and a nitride insulating layer.", "In at least one instance, a single layer film of silicon nitride (SiNx), silicon oxide (SiOy), silicon oxynitride (SiOyNx), or aluminum oxide (AlOx), or stacked films of these can be used as the undercoat layer 20.The film thickness of the undercoat layer 20 is set to be from 100 to 500 nm.", "In at least one embodiment, undercoat layer 20 is omitted.", "The oxide semiconductor layer 30 is usable as a channel layer.", "In other words, the oxide semiconductor layer 30 is a semiconductor layer including a channel region opposing the gate electrode 70 with the gate insulating layer 50 being between the channel region and the gate electrode 70.In at least one embodiment, the oxide semiconductor layer 30 is formed at a position opposite the gate electrode 70 with the gate insulating layer 50 and the fluorine-including layer 60 being between the oxide semiconductor layer 30 and the gate electrode 70.By contrast, the oxide semiconductor layer 40S is a semiconductor layer usable as a source region provided on one side of the oxide semiconductor layer 30.Moreover, the oxide semiconductor layer 40D is a semiconductor layer usable as a drain region provided on the other side of the oxide semiconductor layer 30.The oxide semiconductor layers 40S and 40D each are a low resistance region (offset region) having a resistance value lower than that of the oxide semiconductor layer 30.Moreover, in each of the oxide semiconductor layers 40S and 40D, a resistance value of an upper region (region closer to a side of the interlayer insulating layer 80) is less than that of a lower region (region closer to a side of the undercoat layer 20).", "Stated differently, in each of the oxide semiconductor layers 40S and 40D, the resistance values differ from each other in a stack direction, and the resistance value of the upper layer portion is less than that of the lower layer portion.", "The oxide semiconductor layers 40S and 40D in at least one embodiment are placed in a low resistance state by desorption of oxygen.", "The oxide semiconductor layers 30, 40S, and 40D are formed in a predetermined shape, on the undercoat layer 20.Moreover, the oxide semiconductor layers 30, 40S, and 40D include the same material.", "A transparent amorphous oxide semiconductor (TAOS) is used for the material of the oxide semiconductor layers 30, 40S, and 40D, for example.", "In at least one embodiment, metallic elements included in each of the oxide semiconductor layers 30, 40S, and 40D include at least indium (In) and further at least one or both of gallium (Ga) and zinc (Zn).", "The oxide semiconductor layers 30, 40S, and 40D in at least one embodiment each include InGaZnOx (IGZO), that is, an oxide including indium (In), gallium (Ga), and zinc (Zn).", "Moreover, the oxide semiconductor layer 30 includes fluorine (F).", "Specifically, fluorine is included in a region that is an internal region in the oxide semiconductor layer 30 and is close to the gate insulating layer 50.In other words, fluorine is included on a front channel side of the oxide semiconductor layer 30, and fluorine is included on a side of the gate insulating layer 50 in the oxide semiconductor layer 30.In contrast, the oxide semiconductor layers 40S and 40D include no fluorine.", "Fluorine that is chemically bonded is included in the oxide semiconductor layer 30.The region that is the internal region in the oxide semiconductor layer 30 and is close to the gate insulating layer 50 is a region that is on the side of the gate insulating layer 50 and is above at least the middle of a thickness of the oxide semiconductor layer 30.The oxide semiconductor layer 30 in at least one embodiment includes a first region (fluorine-including region) which is a region including fluorine, and a second region (no-fluorine-including region) which is a region including no fluorine.", "For example, when the middle of the film thickness of the oxide semiconductor layer 30 is a reference point, the first region in the oxide semiconductor layer 30 is a region (upper layer) above the middle of the film thickness of the oxide semiconductor layer 30, and the second region in the oxide semiconductor layer 30 is a region (lower layer) below the middle of the film thickness of the oxide semiconductor layer 30.In this case, the first region, the upper layer, in the oxide semiconductor layer 30 is a region on the side of the gate insulating layer 50 (front channel side) in the oxide semiconductor layer 30.In at least one embodiment, fluorine is included only in the region on the side of the gate insulating layer 50 (side of the gate electrode 70) in the oxide semiconductor layer 30.In contrast, the second region, the lower layer, in the oxide semiconductor layer 30 is a region on the side of the substrate 10 (back channel side) in the oxide semiconductor layer 30.As stated before, in the oxide semiconductor layer 30, the region on the side of the gate insulating layer 50 has a fluorine concentration higher than that of the region on the side of the undercoat layer 20.The fluorine-including region in the oxide semiconductor layer 30 may have a thickness of at least 5 nm.", "In at least one embodiment, the fluorine-including region has a thickness of at least 15 nm.", "In at least one embodiments, the fluorine-including region has a thickness of at least 20 nm.", "Moreover, the oxide semiconductor layer 30 may have, as a whole, a film thickness of at least 20 nm.", "Setting the film thickness of the fluorine-including region in the oxide semiconductor layer 30 to be at least 5 nm helps to sufficiently exert the aforementioned effect of including fluorine.", "Moreover, even when hydrogen diffuses from the outside of the oxide semiconductor layer 30 by annealing or the like, setting the film thickness of the fluorine-including region in the oxide semiconductor layer 30 to be at least 15 nm enables the fluorine-including region in the oxide semiconductor layer 30 to block diffusing hydrogen.", "In at least one embodiment, the fluorine-including region is formed on the side of the gate insulating layer 50, and thus hydrogen entering the oxide semiconductor layer 30 from the side of the gate insulating layer 50 can be effectively blocked.", "With this, stable thin film transistor characteristics are obtained.", "Moreover, setting the film thickness of the fluorine-including region in the oxide semiconductor layer 30 to be at least 20 nm helps to sufficiently perform process control of the oxide semiconductor layer 30.In other words, setting the film thickness of the fluorine-including region in the oxide semiconductor layer 30 to be at least 20 nm helps to set the film thickness of the oxide semiconductor layer 30 as a whole to be at least 20 nm.", "With this, deposition of the oxide semiconductor layer 30 by sputtering or the like is possible, and patterning of the oxide semiconductor layer 30 is possible by a photolithography or etching method, for example.", "Furthermore, although the device characteristics of the oxide semiconductor layer 30 deteriorate when the oxide semiconductor layer 30 is damaged by hydrogen annealing, with regard to the oxide semiconductor layer 30 whose surface is damaged by hydrogen annealing, the device characteristics can be recovered by etching 20 nm from the hydrogen-exposed surface.", "Accordingly, the fluorine-including region in the oxide semiconductor layer 30 may be have a film thickness of at least 20 nm.", "Setting the film thickness of the oxide semiconductor layer 30 as a whole to be at least 20 nm makes helps to obtain stable device characteristics as a TFT.", "Moreover, although the gate insulating layer 50 sometimes includes fluorine, the oxide semiconductor layer 30 has a fluorine concentration higher than that of the gate insulating layer 50.In addition, in at least one embodiment, the oxide semiconductor layer 30 has a fluorine concentration higher than a hydrogen concentration of the oxide semiconductor layer 30.In at least one embodiment, the oxide semiconductor layer 30 has a fluorine concentration of at least 1×1022 atm/cm3.The gate insulating layer 50 (insulating layer) is formed above the oxide semiconductor layers 30, 40S, and 40D.", "The gate insulating layer 50 is, for example, a single layer insulating layer of an oxide insulating layer or a nitride insulating layer, or a stacked insulating layer including an oxide insulating layer and a nitride insulating layer.", "The gate insulating layer 50 may be a single layer film of silicon oxide, aluminum oxide (alumina), silicon nitride, silicon oxynitride, tantalum oxide, or the like, or stacked films of these.", "The gate insulating layer 50 having a stacked layer structure may be stacked films of a silicon oxide film and an aluminum oxide film (alumina film).", "The film thickness of the insulating layer 50 can be designed by taking into consideration pressure resistance of the TFT or the like, and in at least one embodiment ranges from 50 to 500 nm, for example.", "In at least one embodiment, the gate insulating layer 50 is formed by atomic layer deposition (ALD).", "For example, the gate insulating layer 50 is deposited by causing a surface chemical reaction in the interface of an oxide semiconductor film by supplying the oxide semiconductor film with reactive gas containing molecules (precursors) including an alkyl group (—CnH2n+1) and elements included in the gate insulating layer 50.For example, when a silicon oxide film (SiO film) is deposited as the gate insulating layer 50 by ALD, tris(dimethylamino)silane (C6H19N3Si) or tetraethoxysilane (Si(OC2H5)4)) may be used as molecules containing an alkyl group and Si elements included in the gate insulating layer 50.Furthermore, when an aluminum oxide film (AlOx film) is deposited as the gate insulating layer 50 by ALD, trimethylaluminum (Al(CH3)3) may be used as molecules containing an alkyl group and Al elements included in the gate insulating layer 50.The gate insulating layer 50 may be formed by another method such as plasma CVD, instead of ALD.", "Moreover, as stated above, the gate insulating layer 50 sometimes includes fluorine.", "In this case, fluorine included in the gate insulating layer 50 is fluorine diffused from the fluorine-including layer 60, and is thought to be chemically adsorbed to dangling bonds in the gate insulating layer 50.In other words, fluorine in the gate insulating layer 50 is thought to be chemically bonded with the elements constituting the gate insulating layer 50.Although some fluorine in the gate insulating layer 50 is thought to be physically adsorbed, chemically bonded fluorine in the gate insulating layer 50 is thought to be more dominant.", "The fluorine-including layer 60 is a layer including at least fluorine (F).", "Moreover, the fluorine-including layer 60 functions as a fluorine-supplying layer that supplies other layers with fluorine by fluorine included in the fluorine-including layer 60 being diffused by subsequent annealing.", "As described later, fluorine in the fluorine-including layer 60 compensates oxygen deficiency in the oxide semiconductor film by being diffused into the oxide semiconductor film by annealing.", "The fluorine-including layer 60 in at least one embodiment is an insulating layer made of an insulating material.", "The fluorine-including layer 60 may be a fluorine layer including only fluorine or an organic layer which includes fluorine and is made of an organic material.", "When the fluorine-including layer 60 is the fluorine layer, for example, the fluorine-including layer 60 is a layer obtained by fluorine being physically adsorbed above the oxide semiconductor layer 30.In contrast, when the fluorine-including layer 60 is the organic layer, fluorine is physically adsorbed in the organic material (organic layer).", "Examples of the organic material to which fluorine is physically adsorbed include a resin material such as CYTOP.", "The fluorine-including layer 60, the organic layer, may include both fluorine physically adsorbed to the organic layer and fluorine physically bonded with the organic material of the organic layer.", "However, in at least one embodiment, fluorine physically adsorbed is more dominant than fluorine chemically bonded with the organic material.", "Furthermore, when the fluorine-including layer 60 is the organic layer, the gate insulating layer 50 may be an inorganic layer includes an inorganic material such as a resin material.", "In this case, the gate insulating layer 50 is, for example, a silicon oxide layer or an aluminum oxide layer.", "Moreover, evaluating whether chemically bonded fluorine or physically adsorbed fluorine is dominant in the fluorine-including layer 60 or the gate insulating layer 50 is possible, by using X-ray photoelectron spectroscopy (XPS).", "For example, even when fluorine is physically adsorbed or chemically bonded, a peak appears in an F1s XPS spectrum.", "Evaluate whether chemically bonded fluorine or physically adsorbed fluorine is dominant is possible, depending on whether the peak is on a high binding energy side or a low binding energy side in the XPS spectrum.", "The fluorine-including layer 60 is formed at a position opposite the oxide semiconductor layer 30 with the gate insulating layer 50 being between the fluorine-including layer 60 and the oxide semiconductor layer 30.In addition, the fluorine-including layer 60 is disposed between the gate insulating layer 50 and the gate electrode 70.In at least one embodiment, a channel direction length of the fluorine-including layer 60 is almost identical to a channel direction length of the oxide semiconductor layer 30 and a channel direction length of the gate electrode 70.In other words, in cross-sectional view, both side surfaces of the fluorine-including layer 60 are flush with both side surfaces of the oxide semiconductor layer 30 as well as both side surfaces of the gate electrode 70.Moreover, in plan view, the gate electrode 70, the fluorine-including layer 60, and the oxide semiconductor layer 30 may be formed to completely overlap with each other.", "In this case, the fluorine-including layer 60 does not overlap with the oxide semiconductor layers 40S and 40D, and the oxide semiconductor layers 40S and 40D are not below the fluorine-including layer 60.The gate electrode 70 is formed at a position opposite the oxide semiconductor layer 30 with the gate insulating layer 50 being between the gate electrode 70 and the oxide semiconductor layer 30.In at least one embodiment, the gate electrode 70 is formed at a position opposite the oxide semiconductor layer 30 with the gate insulating layer 50 and the fluorine-including layer 60 being between the gate electrode 70 and the oxide semiconductor layer 30.Specifically, the gate electrode 70 is formed in a predetermined shape, on the fluorine-including layer 60.The gate electrode 70 is an electrode having a single layer structure or a multi-layer structure including a conductive material such as metal or an alloy thereof, and may include molybdenum (Mo), aluminum (Al), copper (Cu), tungsten (W), titanium (Ti), chrome (Cr), or molybdenum tungsten (MoW), for example.", "In at least one embodiment, the film thickness of the gate electrode 70 is set to be from 50 to 300 nm.", "The interlayer insulating layer 80 is formed to cover the gate electrode 70 and the oxide semiconductor layers 40S and 40D.", "The interlayer insulating layer 80 may be made of a material including an organic substance as a main component or may include an inorganic substance such as silicon oxide, silicon nitride, silicon oxynitride, and aluminum oxide.", "In addition, the interlayer insulating layer 80 may be a single layer film or a film having stacked layers.", "The interlayer insulating layer 80 having a stacked layer structure may be, for example, stacked films of a silicon oxide film and an aluminum oxide film.", "Moreover, in the interlayer insulating layer 80, openings (contact holes) are formed to penetrate part of the interlayer insulating layer 80.The oxide semiconductor layer 40S is connected to the source electrode 90S, and the oxide semiconductor layer 40D is connected to the drain electrode 90D, via the openings of the interlayer insulating layer 80.The source electrode 90S and the drain electrode 90D are formed in a predetermined shape, on the interlayer insulating layer 80.Moreover, the source electrode 90S and the drain electrode 90D are each electrically connected to the oxide semiconductor layer 30.In the embodiment, the source electrode 90S and the drain electrode 90D are each electrically and physically connected to a different one of the oxide semiconductor layers 40S and 40D via the openings formed in the interlayer insulating layer 80, and are electrically connected to the oxide semiconductor layer 30 via the oxide semiconductor layers 40S and 40D.", "The source electrode 90S and the drain electrode 90D each are an electrode having a single layer structure including an conductive material or an alloy thereof, or a stacked layer structure of these.", "The source electrode 90S and the drain electrode 90D may include, for example, molybdenum (Mo), aluminum (Al), copper (Cu), tungsten (W), titanium (Ti), chrome (Cr), molybdenum tungsten alloy (MoW), or copper manganese allow (CuMn).", "In at least one embodiment, the film thickness of the source electrode 90S and the drain electrode 90D is set to be from 50 to 300 nm, for example.", "[Method for Manufacturing Thin Film Transistor] Next, a method for manufacturing the thin film transistor 1 according to at least one embodiment will be described with reference to FIGS.", "2A to 2I.", "FIGS.", "2A to 2I are cross-sectional views of processes in the method for manufacturing the thin film transistor according to at least one embodiment of the present description.", "First, in FIG.", "2A, the substrate 10 is prepared.", "A glass substrate is used as the substrate 10, for example.", "Next, in FIG.", "2B, the undercoat layer 20 is formed on the substrate 10.For example, the undercoat layer 20 including a silicon nitride film, a silicon oxide film, a silicon oxynitride film, an aluminum oxide film, or the like is formed on the substrate 10 by plasma chemical vapor deposition (CVD) or the like.", "Next, in FIG.", "2C, an oxide semiconductor film SC is deposited on the undercoat layer 20.The oxide semiconductor film SC may include an InGaZnOx transparent amorphous oxide semiconductor.", "In this case, the oxide semiconductor film (InGaZnOx film) SC including InGaZnOx can be deposited by a vapor deposition method such as a sputtering method or a laser evaporation method.", "Specifically, a target material including In, Ga, and Zn (for example, a polycrystalline sintered body having an InGaO3(ZnO)4 composition) is used, an argon (Ar) gas as an inert gas and a gas including oxygen (O2) as a reactive gas are introduced into a vacuum chamber, and voltage of a predetermined power density is applied to the target material.", "Though not shown, after the oxide semiconductor film SC is deposited, the oxide semiconductor film SC can be formed in a predetermined shape by patterning the oxide semiconductor film SC using a photolithography or wet etching method.", "Specifically, a resist having a predetermined shape is formed on the oxide semiconductor film SC, and part of the oxide semiconductor film SC in a region where the resist is not formed is removed by wet etching, thereby forming the oxide semiconductor film SC having an island shape.", "When the oxide semiconductor film SC includes InGaZnOx, a chemical solution obtained by mixing, for example, phosphoric acid (H3PO4), nitric acid (HNO3), acetic acid (CH3COOH), and water may be used as an etching solution.", "Next, in FIG.", "2D, the gate insulating layer 50 is formed on the oxide semiconductor film SC.", "The gate insulating layer 50 is, for example, a silicon nitride film, a silicon oxide film, a silicon oxynitride film, a tantalum oxide film, an aluminum oxide film, or stacked layers of these.", "In at least one embodiment, the gate insulating layer 50 is deposited by ALD.", "Specifically, the gate insulating layer 50 is deposited as a whole on a top surface of the oxide semiconductor film SC by ALD.", "Processing costs are reduced by depositing the gate insulating layer 50 as a whole.", "Moreover, the gate insulating layer 50 may be deposited not by ALD but by plasma CVD.", "For example, when a SiO film is deposited as the gate insulating layer 50 by plasma CVD, as in FIGS.", "3A-B, the SiO film can be deposited using a mixture gas of monoslinae (SiH4) and nitrous oxide (N2O).", "When the SiO film is deposited by plasma CVD, the SiO film is deposited by SiH4 gas and N2O gas being reacted with each other in a vapor phase, but, in this case, unlike ALD, a reaction does not occur in which the oxide semiconductor film SC is placed in the low resistance state.", "Accordingly, when a source region and a drain region are formed in the oxide semiconductor film SC, part of the oxide semiconductor film SC is placed in the low resistance state by separately performing plasma processing etc.", "Next, after the gate insulating layer 50 is formed, in FIG.", "2E, the fluorine-including layer 60 is formed on the gate insulating layer 50.The fluorine-including layer 60 is formed on the gate insulating layer 50 above a region of an oxide semiconductor film SC°−.", "Specifically, the fluorine-including layer 60 is formed only above a portion of the oxide semiconductor film SC°− that is to be a channel region.", "When a fluorine layer including only fluorine is formed as the fluorine-including layer 60, the fluorine-including layer 60 can be formed by performing, while supplying fluorine system gas, annealing treatment or discharge treatment to adsorb fluorine on the gate insulating layer 50.In this case, the fluorine-including layer 60 is formed as a layer obtained by fluorine being physically adsorbed to a surface of the gate insulating layer 50.Moreover, as stated above, although the fluorine-including layer 60 is formed only above the portion of the oxide semiconductor film SC°− that is to be the channel region, in this case, fluorine system gas may be supplied after a mask is placed to cover a portion of the gate insulating layer 50 (portion in which the fluorine-including layer 60 is not formed).", "As a result, the fluorine-including layer 60 only above the portion of the oxide semiconductor film SC°− that is to be the channel region.", "In contrast, when an organic layer including fluorine is formed as the fluorine-including layer 60, the organic layer including fluorine is formed by forming an organic layer by applying an organic material to only a predetermined region of the gate insulating layer 50, and by adsorbing fluorine to the organic layer.", "It is to be noted that a method for forming the fluorine-including layer 60 is not limited to a method by which fluorine of the fluorine-including 60 is diffused into the oxide semiconductor film SC°− via the gate insulating layer 50 in subsequent annealing.", "Next, in FIG.", "2F, the fluorine-including layer 60 is annealed after the fluorine-including layer 60 is formed.", "This annealing causes fluorine to diffuse (thermal diffuse) from the fluorine-including layer 60, and to be chemically bonded in the oxide semiconductor film SC°−.", "An annealing temperature may be at least a temperature at which fluorine adsorbed to the fluorine-including layer 60 on the gate insulating layer 50 starts to desorb, and is, for example, 300° C. The details of the annealing at this time will be described with reference to FIG.", "4.FIG.", "4 is a diagram for describing the details of the annealing in FIG.", "2F.", "In FIG.", "4A, in at least one embodiment, the fluorine-including layer 60 is formed only above a region of the oxide semiconductor film SC°−.", "Subsequently, in FIG.", "4B, the annealing causes fluorine to thermally diffuse only into a portion covered with the fluorine-including layer 60 and included in the region of the oxide semiconductor film SC°− (region in which the reactive gas when the gate insulating layer 50 is deposited causes oxygen to desorb from the oxygen semiconductor film SC), and to be chemically bonded in the oxide semiconductor film SC°−.", "Accordingly, oxygen deficiency in the oxide semiconductor film SC°− caused when the gate insulating layer 50 is deposited by ALD is compensated for with fluorine diffused from the fluorine-including layer 60.In consequence, in FIG.", "4C, because the oxygen deficiency is compensated for with fluorine diffused from the fluorine-including layer 60, the portion of the oxide semiconductor film SC°− directly below and covered with the fluorine-including layer 60 becomes the oxide semiconductor layer 30 functioning as the channel layer.", "In other words, a function as a semiconductor layer is restored by compensating, with fluorine, the oxide semiconductor film which is placed in a low resistance state (conductive state) by the desorption of oxygen.", "In contrast, because the oxygen deficiency is not compensated for with fluorine, portions of the oxide semiconductor film SC°− not covered with the fluorine-including layer 60 remain low resistance regions and become the oxide semiconductor layers 40S and 40D respectively functioning as the source region and the drain region.", "Although fluorine is not actively diffused into the oxide semiconductor layers 40S and 40D, when fluorine is diffused into the oxide semiconductor layer 30, fluorine may naturally go into the oxide semiconductor layers 40S and 40D.", "Accordingly, surface layers or regions of the oxide semiconductor layers 40S and 40D neighboring the oxide semiconductor layer 30 may slightly include fluorine.", "Moreover, when the fluorine-including layer 60 is either the fluorine layer or the organic layer including fluorine, the fluorine-including layer 60 is present after the annealing.", "In this case, the fluorine-including layer 60 still includes fluorine after the annealing.", "As stated above, the oxide semiconductor layer 30 is selectively formed as usable as the channel layer, the oxide semiconductor layer 40S to be the source region, and the oxide semiconductor layer 40D to be the drain region, by compensating, with fluorine, the oxygen deficiency in the portion of the oxide semiconductor film SC°− caused when the gate insulating layer 50 is deposited by ALD, and by intentionally leaving the other portions thereof without compensating the other portions with fluorine.", "In other words, the source region (oxide semiconductor layer 40S) and the drain region (oxide semiconductor layer 40D) are formed in a self-aligning manner, by selectively compensating, with fluorine, the oxygen deficiency in the portion of the oxide semiconductor film SC°−, and by leaving the other portions with the oxygen deficiency as the low resistance regions.", "When fluorine diffuses from the fluorine-including layer 60 into the oxide semiconductor film SC°−, see FIGS.", "4A-C, fluorine passes through the gate insulating layer 50.At this time, fluorine may be present in the gate insulating layer 50 by being captured by dangling bonds (defects) in the gate insulating layer 50.In other words, dangling bonds in the gate insulating layer 50 are terminated with fluorine by diffusing fluorine via the gate insulating layer 50.Moreover, a peak position of an F1S XPS spectrum in the fluorine-including layer 60 shifts closer to the high biding energy side after the annealing than before the annealing.", "Accordingly, after the annealing, chemically bonded fluorine seems to be more dominant than physically bonded fluorine in the fluorine-including layer 60.Furthermore, in at least one embodiment, a peak position of an Si2p XPS spectrum in the gate insulating layer 50 shifts closer to the high binding energy side after the annealing than before the annealing.", "This is because the annealing seems to have caused fluorine to be chemically bonded in the gate insulating layer 50.Next, in FIG.", "2G, the gate electrode 70 is formed on the fluorine-including layer 60.In the embodiment, the gate electrode 70 is formed only above the fluorine-including layer 60 and the oxide semiconductor layer 30, but the embodiment is not limited to this.", "For example, the gate electrode 70 is formed in a predetermined shape by depositing, by sputtering, a metal film (gate metal film) including molybdenum tungsten (MoW), and then by patterning the metal film using a photolithography or wet etching method.", "For the wet etching of MoW, a chemical solution can be used which is obtained by mixing, for example, phosphoric acid (HPO4), nitric acid (HNO3), acetic acid (CH3COOH), and water in a predetermined combination ratio.", "Next, in FIG.", "2H, the interlayer insulating layer 80 is formed to cover the gate insulating layer 50 and the gate electrode 70.The interlayer insulating layer 80 may include an organic substance as a main component or an inorganic substance such as a silicon oxide film.", "For example, a silicon oxide film may be deposited as the interlayer insulating layer 80 by plasma CVD.", "Then, the openings (contact holes) are formed in the interlayer insulating layer 80 to expose part of each of the oxide semiconductor layers 40S and 40D.", "Specifically, part of the interlayer insulating layer 80 is etched away by a photolithography or etching method, thereby forming the openings above connection portions with the source electrode 90S and the drain electrode 90D in the respective oxide semiconductor layers 40S and 40D.", "For example, when the oxide semiconductor layers 40S and 40D each are a silicon oxide film, the openings can be formed in the silicon oxide film by a dry etching method such as a reactive ion etching (RIE) method.", "In this case, carbon tetrafluoride (CF4) and oxygen gas (O2), for example, can be used as etching gas.", "Next, in FIG.", "21, the source electrode 90S and the drain electrode 90D are formed which are connected to the oxide semiconductor layers 40S and 40D via the openings formed in the interlayer insulating layer 80.In at least one embodiment, the source electrode 90S and the drain electrode 90D having a predetermined shape are formed by depositing, by sputtering, a metal film (source-drain metal film) on the interlayer insulating layer 80 to fill the openings formed in the interlayer insulating layer 80, and then by patterning the metal film using the photolithography or wet etching method.", "Though not illustrated, for example, a heat treatment at 300° C. (annealing) is performed subsequently.", "This heat treatment makes it possible to reduce oxygen deficiency in the oxide semiconductor layer 30 to stabilize characteristics of the oxide semiconductor layer 30.", "[Operational Effect of Thin Film Transistor] The following describes an operational effect of the thin film transistor 1 according to at least one embodiment together with the background to the present description.", "In recent years, not only bottom-gate oxide semiconductor TFTs but also top-gate oxide semiconductor TFTs have been much developed, the bottom-gate oxide semiconductor TFTs being highly compatible with amorphous silicon TFTs for liquid crystal display, the top-gate oxide semiconductor TFTs having merits of, for example, being easily miniaturized and having small parasitic capacitance.", "For example, Non Patent Literature (NPL) 1 describes a top-gate TFT in which a gate insulating layer and a gate electrode are formed in the same shape, on a channel region in an oxide semiconductor layer, and a source region and a drain region are formed by placing, into a low resistance state, a region not covered with the gate insulating layer and the gate electrode in the oxide semiconductor layer.", "A difficulty in manufacturing the top-gate TFT is how low resistance regions (the source region and the drain region) are formed in the oxide semiconductor layer.", "For example, in NPL 1, the source region and the drain region are formed by placing the oxide semiconductor layer into the low resistance state by being exposed to plasma atmosphere including argon gas.", "Moreover, in order for low parasitic capacitance, a bottom-gate TFT disclosed by Patent Literature (PTL) 2 uses both hydrogen introduction from a silicon nitride film and plasma processing with hydrogen gas when a source region and a drain region are formed by placing an oxide semiconductor layer into a low resistance state.", "However, these methods cause the device characteristics of the TFT to depend on the plasma processing having many variables, which makes mass-producing stable TFTs difficult.", "In addition, as described in Non Patent Literature (NPL) 2, because an oxide semiconductor layer is very sensitive to hydrogen, a variation in device characteristics or degradation of reliability is caused by process damage resulting from hydrogen or the like in a manufacturing process.", "The present description has been conceived based on such knowledge, and the inventor of at least one embodiment of the present description has arrived at an idea of obtaining a thin film transistor having high reliability by forming a fluorine-including layer and diffusing fluorine from the fluorine-including layer into the oxide semiconductor layers 30, 40S, and 40D as described above.", "Moreover, the inventor thereof has found a method for forming a low resistance region in an oxide semiconductor layer without using hydrogen or plasma processing, and has succeeded in achieving a thin film transistor including an oxide semiconductor layer having a channel region having high stability, and a source region and a drain region formed with no damage to plasma and hydrogen.", "The following describes in detail an operation effect of including fluorine in an oxide semiconductor layer, and a point that a low resistance region can be formed in the oxide semiconductor layer without using plasma and hydrogen, with reference to the drawings.", "The inventor has conducted various experiments to verify whether a thin film transistor having high reliability is obtained by including fluorine in an oxide semiconductor layer.", "The following describes the experiments and analyses thereof.", "In the following experiments an InGaZnOx film whose main components of metallic elements are In, Ga, and Zn is used as the oxide semiconductor layer.", "First, a point that oxygen deficiency can be compensated by including fluorine in the oxide semiconductor layer will be described with reference to FIG.", "5.FIG.", "5 is a graph of the results of measuring, using four-terminal sensing, a sheet resistance value in vacuum heating (300° C.) for the case where fluorine is included in the oxide semiconductor layer and the case where fluorine is not included in the oxide semiconductor layer.", "Charge carriers are generated by oxygen deficiency (desorption of oxygen) to decrease a resistance value of the oxide semiconductor layer.", "In FIG.", "5, a sheet resistance value in the case where fluorine is not included in the oxide semiconductor layer (IGZO including no F) is low such as approximately 1×105 Ω/□.", "By contrast, a sheet resistance value in the case where fluorine is included in the oxide semiconductor layer (IGZO including F) is a measurement limit (>1×1010 Ω/□) and is higher than the sheet resistance value in the case fluorine is not included in the oxide semiconductor layer.", "This is because, since fluorine has higher binding energy with metal than oxygen, including fluorine in the oxide semiconductor layer enables fluorine to eliminate dangling bonds or an unstable site caused by the oxygen deficiency in the oxide semiconductor layer.", "These results indicate that including fluorine in the oxide semiconductor layer results in a structure in which charge carriers are less likely to be generated, that is, a structure which compensates the oxygen deficiency to be insensitive to the oxygen deficiency.", "Next, a point that hydrogen resistance can be improved by including fluorine in the oxide semiconductor layer will be described with reference to FIGS.", "6 to 8.FIG.", "6 is a cross-sectional view of a device structure of a sample used in an experiment for hydrogen resistance according to at least one embodiment.", "In FIG.", "6, in the experiment, a sample is used which has a three layer structure in which an oxide semiconductor layer (IGZO), a silicon oxide layer (SiO), and a silicon nitride layer (SiN:H) including hydrogen are stacked above a glass substrate.", "FIG.", "7 is a graph, for the sample having the structure in FIG.", "6, of μ-PCD peak intensity and a resistance value of the oxide semiconductor layer when the film thickness of the silicon oxide layer is varied.", "The film thickness of the silicon oxide layer is varied to 10 nm, 120 nm, and 240 nm.", "Moreover, the resistance value of the oxide semiconductor layer is measured by a non-contact resistance measurement device.", "In FIG.", "7, there is a positive correlation between the resistance value of the oxide semiconductor layer (IGZO) and the μ-PCD peak intensity.", "In other words, the resistance value of the oxide semiconductor layer (IGZO) and the μ-PCD peak intensity give an indication of determining hydrogen-induced damage due to the presence or absence of fluorine introduction.", "FIG.", "8 is a graph of the results of comparing μ-PCD peak intensity and the presence or absence of fluorine introduction to an oxide semiconductor layer.", "In FIG.", "8, if fluorine is not included in the oxide semiconductor layer, a μ-PCD intensity value (a ratio of a peak intensity value before depositing SiN: H film to a peak intensity value after depositing SiN: H film) in the oxide semiconductor layer decreases.", "In other words, a resistance value barely varies even if fluorine is introduced when the resistance value is low, that is, the resistance value does not decrease.", "In general, if hydrogen is included in an oxide semiconductor layer, the included hydrogen bonds with oxygen in the oxide semiconductor layer to generate charge carriers.", "In view of, even if hydrogen is included in the oxide semiconductor layer, including fluorine in the oxide semiconductor layer and bonding fluorine with the oxide semiconductor layer prevent the included hydrogen from bonding with the oxide semiconductor layer.", "The inventor presumes that since fluorine has one valence arm, there is no valence arm available even if hydrogen enters and hydrogen is inert.", "As just described, including fluorine in the oxide semiconductor layer can prevent the generation of the charge carriers in the oxide semiconductor layer.", "In short, including fluorine in the oxide semiconductor layer makes it possible to improve the hydrogen resistance.", "Next, a point that a structure of the oxide semiconductor layer is stabilized by including fluorine in the oxide semiconductor layer will be described with reference to FIGS.", "9A to 9C and FIG.", "10.FIGS.", "9A to 9C are each a graph of a corresponding one of In3d5, Zn1p3, and Ga2p3 XPS spectra in the case where fluorine is included in an oxide semiconductor layer (IGZO) (IGZO including F) and a corresponding one of In3d5, Zn1p3, and Ga2p3 XPS spectra in the case where fluorine is not included in an oxide semiconductor layer (IGZO) (IGZO including no F).", "In FIG.", "9A, the inclusion of fluorine causes a peak position of the In3d5 XPS spectrum to shift to a high binding energy side by at least 0.5 eV.", "In other words, a peak position of In3d5 in IGZO including F measured by XPS is shifted to the high binding energy side by at least 0.5 eV in comparison to a peak position of In3d5 in IGZO including no F. Moreover, in FIG.", "9B, the inclusion of fluorine causes a peak position of the Zn2p3 XPS spectrum to shift to the high binding energy side by at least 0.4 eV.", "In other words, a peak position of Zn2p3 in IGZO including F measured by XPS is shifted to the high binding energy side by at least 0.4 eV in comparison to a peak position of Zn2p3 in IGZO including no F. Furthermore, in FIG.", "9C, the inclusion of fluorine causes a peak position of the Ga2p3 XPS spectrum to shift to the high binding energy side by at least 0.5 eV.", "In other words, a peak position of Ga2p3 in IGZO including F measured by XPS is shifted to the high binding energy side by at least 0.5 eV in comparison to a peak position of Ga2p3 in IGZO including no F. The results in FIGS.", "9A to 9C indicate that including fluorine in the oxide semiconductor layer results in not merely fluorine being physically in the oxide semiconductor layer but in fluorine being chemically bonded with elements included in the oxide semiconductor layer.", "Consequently, the metallic elements included in the oxide semiconductor layer are less likely to escape.", "As just described, including fluorine in the oxide semiconductor layer results in the metallic elements included in the oxide semiconductor layer being chemically bonded with fluorine, which helps to stabilize the structure of the oxide semiconductor layer.", "With this, a thin film transistor having high reliability is possible.", "FIG.", "10 is a graph of a Zn thermal desorption spectrum by thermal desorption spectrometry (TDS) in the case where fluorine is included in the oxide semiconductor layer (IGZO) (IGZO including F) and a Zn thermal desorption spectrum by TDS in the case where fluorine is not included therein (IGZO including no F).", "In FIG.", "10 the oxide semiconductor layer in the case where fluorine is included therein has a fluorine concentration of 1×1022 atm/cm3 or more.", "Moreover, in FIG.", "10, the horizontal axis indicates a temperature (° C.) at which Zn undergoes thermal desorption, and the vertical axis indicates an amount of Zn undergoing thermal desorption (arbitrary unit).", "In FIG.", "10, the thermal desorption of Zn in the oxide semiconductor layer (IGZO including F) in the case where fluorine is included therein occurs at a temperature higher by at least 50° C. in comparison to the thermal desorption of Zn in the oxide semiconductor layer (IGZO including no F) in the case where fluorine is not included therein.", "In other words, including fluorine in the oxide semiconductor layer so that the fluorine concentration is at least 1×1022 atm/cm3 causes the temperature (thermal desorption temperature) at which Zn undergoes the thermal desorption to increase by 50° C. This is because oxygen desorbs from Zn—O bonds to destabilize Zn, which causes the desorption of Zn.", "A thermal desorption temperature can be used as a physical property index of an oxide semiconductor layer, and an increase in the thermal desorption temperature indicates that a structure of the oxide semiconductor layer is stabilized.", "As just described, also from the standpoint of the thermal desorption temperature of Zn, including fluorine in the oxide semiconductor layer results in the metallic elements included in the oxide semiconductor layer being chemically bonded with fluorine, which helps to stabilize the structure of the oxide semiconductor layer.", "From these results, by including fluorine in the oxide semiconductor layer 30, the oxygen deficiency in the oxide semiconductor layer 30 is compensated for to improve the hydrogen resistance of the oxide semiconductor layer 30 and further stabilize the structure of the oxide semiconductor layer 30.Next, the following describes a point that an insulating layer is formed by chemical reaction in an interface of an oxide semiconductor film caused by supplying reactive gas containing molecules including an alkyl group, and accordingly a source region and a drain region can be formed only by reaction of oxygen deficiency in a top surface of the oxide semiconductor film without using plasma or diffusion of hydrogen.", "The InGaZnOx film is used as the oxide semiconductor film (oxide semiconductor layer) in the following experiment as well.", "FIG.", "11 is a graph of resistance values of an oxide semiconductor film in the case where ALD is used and in the case where ALD is not used.", "In FIG.", "11, “No processing” indicates a sheet resistance value of an IGZO film (no heating) deposited by plasma CVD, “Vacuum heat treatment” indicates a sheet resistance value of an IGZO film (left under atmosphere of 150° C.) deposited by plasma CVD, “ALD AlO” indicates a sheet resistance value of AlOx film deposited by ALD using as trimethylaluminum a precursor, and “ALD SiO” indicates a sheet resistance value of an SiO film deposited by ALD using tris(dimethylamino)silane as a precursor.", "In FIG.", "11, in the cases of “No processing” and “Vacuum heat treatment,” the sheet resistance values are a measurement limit (>1E+10 [Ω/□]).", "Moreover, the sheet resistance values are almost identical between the cases of “No processing” and “Vacuum heat treatment.” The application of heat at approximately 150° C. does not cause the oxygen deficiency in the IGZO film, and the resistance value does not vary.", "In contrast, in the cases of “ALD AlO” and “ALD SiO,” the sheet resistance values are approximately 1E+6 [Ω/□], and it has been found that the sheet resistance values get much lower than in the cases of “No processing” and “Vacuum heat treatment.” As above, factors contributing to the reduction in resistance value of the oxide semiconductor film, a foundation film, by depositing the insulating film by ALD include diffusion of Al metal into the oxide semiconductor film.", "However, because the SiO film including no metal has the resistance value that is reduced to the same degree as that of the AlO film, the diffusion of Al metal is quite unlikely to be a factor.", "Moreover, the oxide semiconductor layer 30 may have a fluorine concentration higher than a carbon concentration of the oxide semiconductor layer 30.Accordingly, sufficiently compensating for the oxygen deficiency in the oxide semiconductor film with fluorine due to carbon is possible.", "As above, according to the thin film transistor 1 in at least one embodiment, fluorine is included in a region that is in the oxide semiconductor layer 30 and close to the gate insulating layer 50.With this, the oxygen deficiency in the oxide semiconductor layer 30 is compensated for with fluorine.", "Moreover, improving the hydrogen resistance of the oxide semiconductor layer 30 is possible.", "Furthermore, the structure of the oxide semiconductor layer 30 is stabilized.", "Accordingly, a thin film transistor having high reliability and high robustness is possible.", "Moreover, according to the thin film transistor 1 in at least one embodiment, the fluorine-including layer 60 is disposed between the gate electrode 70 and the gate insulating layer 50.With this, shifting a threshold voltage (Vth) of the thin film transistor 1 to the positive side is possible.", "Accordingly, a thin film transistor having superior device characteristics is possible.", "Moreover, according to the thin film transistor 1 in the embodiment, fluorine is not included in the oxide semiconductor layers 40S and 40D to be the source region and the drain region, respectively.", "With this, the oxygen deficiency is caused in the oxide semiconductor film, and the oxide semiconductor layer 40S (source region) and the oxide semiconductor layer 40D (drain region) are formed, by placing the oxide semiconductor film into the low resistance state without using plasma or hydrogen.", "In particular, in at least one embodiment, an oxygen deficient region (low resistance region) is formed in the oxide semiconductor film SC by carbon when the gate insulating layer 50 is deposited by ALD causing oxygen to desorb, and subsequently fluorine is thermally diffused into the oxygen deficient region of the oxide semiconductor film.", "Accordingly, the oxide semiconductor film placed in the low resistance state (conductive state) by carbon included in process gas is compensated with fluorine once, which makes it possible to restore the function as the semiconductor layer to the oxide semiconductor film.", "Moreover, according to the thin film transistor 1 in at least one embodiment, the region that is in the oxide semiconductor layer 30 and close to the gate insulating layer 50 has a fluorine concentration higher than that of a region that is in the oxide semiconductor layer 30 and far from the gate insulating layer 50.In other words, a portion of the region (a top surface layer of the oxide semiconductor layer 30) that is in the oxide semiconductor layer 30 and close to the gate insulating layer 50 (fluorine-including layer 60) is the oxygen deficient region, and only this region is compensated with fluorine.", "With this, reducing an amount of fluorine in the oxide semiconductor layer compared to when the oxide semiconductor layer 30 as a whole is the oxygen deficient region is possible and the whole region is compensated for with fluorine.", "This helps to keep a carrier density high, and thus it is possible to ensure on-state current.", "Accordingly, a thin film transistor having superior ON characteristics is possible.", "Moreover, according to a method for manufacturing the thin film transistor 1 in at least one embodiment, fluorine is diffused from the fluorine-including layer 60 into the oxide semiconductor film by annealing the fluorine-including layer 60 after the fluorine-including layer 60 is formed.", "With this, the oxide semiconductor layer 30 in which the oxygen deficiency in the oxide semiconductor film is compensated for with fluorine is formed.", "As a result, the oxide semiconductor layer 30 having superior hydrogen resistance as well as a stable structure is formed.", "Accordingly, a thin film transistor having high reliability and high robustness is possible.", "Moreover, in at least one embodiment, the gate insulating layer 50 is disposed between the fluorine-including layer 60 and the oxide semiconductor layer 30.For this reason, when fluorine is thermally diffused from the fluorine-including layer 60 at the time of annealing, fluorine is diffused through the gate insulating layer 50.Accordingly, the dangling bonds in the gate insulating layer 50 can be terminated with fluorine.", "Moreover, according to the method for manufacturing the thin film transistor 1 in at least one embodiment, in the forming of the gate insulating layer 50, the gate insulating layer 50 is deposited on the oxide semiconductor film by supplying reactive gas containing molecules including an alkyl group and elements included in the gate insulating layer 50.Specifically, the gate insulating layer 50 is deposited on the oxide semiconductor film by ALD using the reactive gas containing the molecules including the alkyl group.", "Accordingly, in the depositing of the gate insulating layer 50, oxygen desorption is promoted by carbon of the alkyl group desorbing oxygen from the top surface layer of the oxide semiconductor film.", "In consequence, because the oxygen deficiency occurs in the top surface layer of the oxide semiconductor film SC, placing the oxide semiconductor film SC in the low resistance state is possible.", "As above, according to the method in at least one embodiment, placing the oxide semiconductor film in the low resistance state without performing the step involving variables such as unstable plasma or without using hydrogen is possible.", "This helps to form the source region (oxide semiconductor layer 40S) and the drain region (oxide semiconductor layer 40D), which are the low resistance regions, in the oxide semiconductor film without damage caused by plasma and hydrogen.", "Accordingly, a thin film transistor having stable device characteristics and high reliability is possible.", "Moreover, according to the method for manufacturing the thin film transistor 1 in at least one embodiment, the fluorine-including layer 60 is formed above a portion of the oxide semiconductor film.", "With this, when fluorine is diffused from the fluorine-including layer 60 by annealing, fluorine is diffused into a portion of the oxide semiconductor film covered with the fluorine-including layer 60 while fluorine is not diffused into portions of the oxide semiconductor film not covered with the fluorine-including layer 60.As a result, regarding the oxygen deficiency in the oxide semiconductor film occurred when the gate insulating layer 50 is deposited by ALD, the portion covered with the fluorine-including layer 60 is compensated with fluorine, and the portions not covered with the fluorine-including layer 60 are not compensated with fluorine, thereby helping to keep the low resistance regions.", "With this, a thin film transistor having the source region and the drain region on the respective sides of the channel region is achieved, by forming the portion of the oxide semiconductor film compensated with fluorine as the channel region (oxide semiconductor layer 30), and by forming the portions of the oxide semiconductor film not compensated with fluorine as the source region (oxide semiconductor layer 40S) and the drain region (oxide semiconductor layer 40D).", "In addition, the source region and the drain region are formed in the self-aligning manner.", "Therefore, manufacturing a thin film transistor including the oxide semiconductor layer having the channel region including fluorine and having high stability, and the source region and the drain region formed without damage caused by plasma and hydrogen is possible.", "In addition, because the source region and the drain region can be formed in the self-aligning manner, stably providing a thin film transistor is possible.", "[Display Device] The following describes an example where the thin film transistor 1 according to the aforementioned embodiment is applied to a display device, with reference to FIGS.", "12 and 13.An example of application to an organic EL display device will be described in at least one embodiment.", "FIG.", "12 is a cutaway perspective view of part of an organic EL display device according to at least one embodiment.", "FIG.", "13 is an electric circuit diagram of a pixel circuit of the organic EL display device in FIG.", "12 according to at least one embodiment.", "The pixel circuit is not limited to the configuration in FIG.", "13.The above-mentioned thin film transistor 1 can be used as a switching transistor SwTr and a driving transistor DrTr of an active matrix substrate in the organic EL display device.", "In FIG.", "12, an organic EL display device 100 includes a stacked structure of: a TFT substrate (TFT array substrate) 110 in which thin-film transistors are disposed; and organic EL elements (light-emitting units) 130 each including an anode 131 which is a lower electrode (reflecting electrode), and a cathode 133 which is an EL layer (light-emitting layer) 132 and an upper electrode (transparent electrode).", "The TFT substrate 110 in at least one embodiment includes the above-mentioned thin film transistor 1.Pixels 120 are arranged in a matrix in the TFT substrate 110, and a pixel circuit is included in each pixel 120.Each of the organic EL elements 130 is formed corresponding to a different one of the pixels 120, and light emission of the organic EL element 130 is controlled by the pixel circuit included in the corresponding pixel 120.Each organic EL element 130 is formed on an interlayer insulating layer (planarizing layer) formed to cover thin film transistors.", "Moreover, the organic EL element 130 has a configuration in which the EL layer 132 is disposed between the anode 131 and the cathode 133.Furthermore, a hole transport layer is formed stacked between the anode 131 and the EL layer 132, and an electron transport layer is formed stacked between the EL layer 132 and the cathode 133.Other function layers may be formed between the anode 131 and the cathode 133.In addition to the EL layer 132, a function layer to be formed between the anode 131 and the cathode 133 is an organic layer including an organic material.", "Each pixel 120 is driven and controlled by a corresponding one of the pixel circuits.", "Moreover, in the TFT substrate 110, gate lines (scanning lines) 140 are disposed along the row direction of the pixels 120, source lines (signal lines) 150 are disposed along the column direction of the pixels 120 to cross the gate lines 140, and power supply lines (not in FIG.", "12) are disposed parallel to the source lines 150.The pixels 120 are partitioned from one another by, for example, the crossing gate lines 140 and source lines 150.The gate lines 140 are connected, on a row by row basis, to the gate electrodes of the switching transistors included in the respective pixel circuits.", "The source lines 150 are connected, on a column by column basis, to the source electrodes of the switching transistors.", "The power supply lines are connected, on a column by column basis, to the drain electrodes of the driving transistors included in the respective pixel circuits.", "In FIG.", "13, the pixel circuit includes the switching transistor SwTr, the driving transistor DrTr, and a capacitor C which stores data to be displayed by a corresponding one of the pixels 120.In at least one embodiment, the switching transistor SwTr is a TFT for selecting the pixel 120, and the driving transistor DrTr is a TFT for driving the organic EL element 130.The switching transistor SwTr includes: a gate electrode G1 connected to the gate line 140; a source electrode S1 connected to the source line 150; a drain electrode D1 connected to the capacitor C and a gate electrode G2 of a second thin film transistor DrTr; and an oxide semiconductor layer (not illustrated).", "When a predetermined voltage is applied to the gate line 140 and the source line 150 connected to the switching transistor SwTr, the voltage applied to the source line 150 is held as data voltage in the capacitor C. The driving transistor DrTr includes: the gate electrode G2 connected to the drain electrode D1 of the switching transistor SwTr and the capacitor C; a drain electrode D2 connected to the power supply line 160 and the capacitor C; a source electrode S2 connected to the anode 131 of the organic EL element 130; and an oxide semiconductor layer (not illustrated).", "The driving transistor DrTr supplies current corresponding to data voltage held in the capacitor C from the power supply line 160 to the anode 131 of the organic EL element 130 via the source electrode S2.With this, in the organic EL element 130, drive current flows from the anode 131 to the cathode 133, which causes the EL layer 132 to emit light.", "It is to be noted that the organic EL display device 100 having the above-described configuration uses an active-matrix system in which display control is performed for each pixel 120 at a cross-point between the gate line 140 and the source line 150.With this, the switching transistor SwTr and the driving transistor DrTr in each pixel 120 cause the corresponding organic EL element 130 to selectively emit light, and thus an image is displayed.", "As above, the organic EL display device 100 in at least one embodiment uses, as the switching transistor SwTr and the driving transistor DrTr, the thin film transistor 1 having superior device characteristics, high reliability, and high robustness, and thus an organic EL display device having superior reliability is achieved.", "In particular, the thin film transistor 1 is used as the driving transistor DrTr driving the organic EL element 130, and an organic EL display device having superior display performance is achieved.", "[Other Variations etc.]", "As shown above, a thin film transistor and a method for manufacturing the same have been described based on the aforementioned embodiment, but the present description is not limited to above described at least one embodiment.", "For example, in the above described at least one embodiment, although the annealing for diffusing fluorine from the fluorine-including layer 60 is performed right after the fluorine-including layer 60 is formed and before the gate electrode 70 is formed, the present description is not limited to this.", "The annealing may be performed with any timing as long as the fluorine-including layer 60 is formed prior to the annealing.", "In addition, another annealing may be used as the annealing for diffusing fluorine from the fluorine-including layer 60.For example, the other annealing may be annealing for stabilizing the characteristics of the oxide semiconductor layer 30.Moreover, although the amorphous oxide semiconductor of InGaZnOx (IGZO) is used as the oxide semiconductor for use in the oxide semiconductor layer in the above described at least one embodiment, the present description is not limited to this.", "An oxide semiconductor including In such as a polycrystalline oxide semiconductor like InGaO can be used.", "Moreover, although the top-gate TFT has been described in the above described at least one embodiment, the principle of the present description can be applied to the bottom-gate TFTs.", "Moreover, the above described at least one embodiment has described the organic EL display device as the display device including the thin film transistor, but the present description is not limited to this.", "For example, the thin film transistor according to the above described at least one embodiment can be applied to another display device such as a liquid crystal display device.", "In this case, the organic EL display device (organic EL panel) can be used as a flat panel display.", "For example, the organic EL display device can be used as a display panel of any electronic device such as a television set, a personal computer, and a cellular phone.", "Moreover, the scope of the present description includes at least one embodiment obtained by adding various modifications to each embodiment or variation that may be conceived by those skilled in the art or an embodiment obtained by arbitrarily combining components and functions of the embodiment or variation without departing from the spirit of the present description.", "[Industrial Applicability] The thin film transistor according to the present decryption can be widely used in a variety of electric equipment including the thin film transistor, such as display devices (display panels) like organic EL display devices, television sets, personal computers, and cellular phones." ] ]
Patent_15872879
[ [ "REDUCED PRESSURE TREATMENT SYSTEM", "A wound treatment apparatus is provided for treating tissue damage, which comprises a fluid impermeable wound cover sealed over a site for purposes of applying a reduced pressure to the site.", "The apparatus also can include a cover with protrusions on its surface for purposes of monitoring pressure at the site.", "One or more sensors can be positioned under the cover to provide feedback to a suction pump controller.", "The apparatus can have a miniature and portable vacuum source connected to the wound cover." ], [ "1.-4.", "(canceled) 5.A reduced-pressure treatment system, comprising: a dressing; and a reduced-pressure source configured to be fluidly coupled to the dressing, the reduced-pressure source having a control unit, a component module, and a canister.", "6.The reduced-pressure treatment system of claim 5, wherein the control unit comprises: a treatment controller having one or more processors configured to execute software; and a graphical user interface.", "7.The reduced-pressure treatment system of claim 6, wherein the treatment controller further comprises a memory and an input/output unit in communication with the processors.", "8.The reduced-pressure treatment system of claim 7, wherein the input/output unit is configured to communicate with an external module.", "9.The reduced-pressure treatment system of claim 6, wherein the software is configured to control tissue treatment, monitor sensors, generate alarms, and perform communications with devices external to the control unit.", "10.The reduced-pressure treatment system of claim 7, further comprising a storage unit in communication with the treatment controller, the storage unit having databases configured to store treatment information.", "11.The reduced-pressure treatment system of claim 6, further comprising a speaker in communication with the graphical user interface.", "12.The reduced-pressure treatment system of claim 5, further comprising a battery or a cord configured to be plugged into a wall socket connected to the system.", "13.The reduced-pressure treatment system of claim 6, further comprising a manifold controller connected to the treatment controller, the manifold controller configured to receive feedback information from one or more sensors configured to be disposed on the dressing and communicate the feedback information to the treatment controller.", "14.A control unit for a tissue treatment system, the control unit comprising: a communication controller; a communication controller port coupled to the communication controller; and a component module.", "15.A reduced-pressure treatment apparatus, comprising: a dressing; a vacuum system comprising a reduced-pressure source configured to be in fluid communication with the dressing, wherein the vacuum system further comprises a reduced-pressure source controller for controlling the reduced-pressure source; a temperature monitoring system connectable with the vacuum system; and a canister.", "16.The reduced-pressure treatment apparatus of claim 15, wherein the apparatus comprises a computer or data processor and a display device.", "17.The reduced-pressure treatment apparatus of claim 16, wherein the apparatus further comprises a recording device in communication with the computer or data processor.", "18.The reduced-pressure treatment apparatus of claim 17, wherein the recording device is configured to receive data.", "19.The reduced-pressure treatment apparatus of claim 16, wherein the computer or data processor is configured to control tissue treatment, monitor sensors, generate alarms, and perform communications with devices external to the reduced-pressure source controller.", "20.The reduced-pressure treatment apparatus of claim 17, wherein the recording device is in communication with the reduced-pressure source controller and configured to store treatment information.", "21.The reduced-pressure treatment apparatus of claim 16, further comprising a speaker in communication with the display device, wherein the speaker is configured to produce audible sound.", "22.The reduced-pressure treatment apparatus of claim 15, further comprising a battery or a cord configured to be plugged into a wall socket connected to the apparatus.", "23.The reduced-pressure treatment apparatus of claim 15, further comprising a second controller connected to the reduced-pressure source controller, the second controller configured to receive feedback information from one or more sensors configured to be disposed on the dressing and communicate the feedback information to the reduced-pressure source controller.", "24.A control unit for a tissue treatment system, the control unit comprising: a reduced-pressure source controller; and a temperature monitoring system, wherein the temperature monitoring system is connectable to the reduced-pressure source controller." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY <EOH>The present invention is directed to a reduced pressure wound treatment apparatus and method that satisfy the needs described above.", "As described in greater detail below, it has many advantages over existing apparatus when used for its intended purpose, as well as novel features that result in a new reduced pressure wound treatment apparatus and method that are not anticipated, rendered obvious, suggested, or even implied by any of the prior art apparatuses, either alone or in any combination thereof.", "In accordance with the present invention a wound treatment apparatus is provided for treating a wound by applying reduced pressure (i.e.", "pressure that is below ambient atmospheric pressure) to the wound in a controlled manner for a selected time period in a manner that overcomes the disadvantages of currently existing apparatus.", "The application of reduced pressure to a wound provides such benefits as faster healing, increased formation of granulation tissue, closure of chronic open wounds, reduction of bacterial density within wounds, inhibition of burn penetration, and enhancement of flap and graft attachment.", "Wounds that have exhibited positive response to treatment by the application of negative pressure include infected open wounds, decubitus ulcers, dehisced incisions, partial thickness burns, and various lesions to which flaps or grafts have been attached.", "The wound treatment apparatus in accordance with the present invention includes a reduced pressure application appliance that is applied to a treatment site at which there is a wound and normal tissue surrounding the wound.", "The reduced pressure application appliance includes a fluid impermeable wound cover for covering and enclosing the wound.", "In a particular embodiment of the present invention, the wound cover also includes means for visually monitoring the pressure in the area of the site of the wound beneath the wound cover.", "These means include a plurality of protrusions on the surface of the cover that are recessed when a predetermined pressure is present beneath the cover, but are increasingly displaced above the remaining surface of the cover as the pressure beneath the cover increases above a predetermined pressure.", "In a similar manner, the cover may contain areas that are displaced as protrusions away from the remaining surface of the cover toward the wound when reduced pressure is applied beneath the cover, and the displacement of the protrusions decreases as the pressure beneath the cover increases.", "The protrusions may also be a different color (or a different shade of the same color) from that on the remaining surface of the cover.", "In addition, the protrusions may produce a noise as they are displaced away from the remaining surface of the cover, providing an audible indication that the pressure beneath the cover is increasing.", "The appliance also includes sealing means for sealing the wound cover to the surrounding tissue of the wound in order to maintain reduced pressure in the vicinity of the wound during wound treatment.", "When the wound cover is sealed in position over the wound site, a generally fluid-tight or gas-tight sealed enclosure is formed over the wound site.", "The sealing means may be in the form of an adhesive applied to the underside of the wound cover for sealing the wound cover around the periphery of the wound.", "The sealing means may also include a separate sealing member such as an adhesive strip or a sealing ring in the form of a tubular pad or inflatable cuff secured to the wound cover for positioning around the periphery of the wound.", "In selected embodiments, the reduced pressure within the sealed enclosure under the wound cover may serve to seal the wound cover in position at the wound site.", "The reduced pressure appliance also includes a suction port for supplying reduced pressure within the sealed volume enclosed beneath the wound cover.", "The suction port may be in the form of a nipple on the wound cover.", "Alternatively, the suction port may be in the form of a tube attached to the wound cover or provided as a feedthrough beneath the wound cover.", "The appliance may also include an absorbable matrix for placement in the wound in order to encourage tissue in the area of the wound to grow into the matrix during treatment.", "The absorbable matrix is constructed of an absorbable material that is absorbed into the epithelial and subcutaneous tissue in the wound as the wound heals.", "The matrix may vary in thickness and rigidity, and it may be desirable to use a spongy absorbable material for the patient's comfort if the patient must lie upon the appliance during treatment.", "The matrix may also be perforated and constructed in a sponge-type or foam-type structure to enhance gas flow and to reduce the weight of the matrix.", "Because of the absorbable nature of the absorbable matrix, the matrix should require less frequent changing than other dressing types during the treatment process.", "In other circumstances, the matrix may not need to be changed at all during the treatment process.", "A vacuum system is connected with the reduced pressure appliance in order to provide suction or reduced pressure to the appliance.", "For this purpose, the vacuum system includes a suction pump or suction device for connection with the suction port of the appliance for producing the reduced pressure over the wound site.", "The vacuum system may include a section of hose or tube, such as a vacuum hose, that interconnects the suction device with the suction port of the appliance to provide the reduced pressure at the wound site.", "A fluid collection system may be provided intermediate the vacuum hose of the suction device and the suction port of the appliance to trap any exudate that may be aspirated from the wound by the negative pressure appliance.", "A stop mechanism may also be provided for the vacuum system to halt production of the reduced pressure at the wound site in the event that an excessive quantity of exudate has been collected.", "The apparatus may also include a control device for controlling the pump.", "In a particular embodiment of the invention, the wound cover for the reduced pressure appliance may be in the form of a gas impermeable covering sheet of flexible polymer material, such as polyethylene, having an adhesive backing that provides the seal for securing the sheet over the wound site to provide a gas-tight or fluid-tight sealed enclosure over the wound site.", "The vacuum system of the wound treatment apparatus may include a suction pump having a vacuum hose that is connected with a suction tube serving as a suction port for the appliance.", "The suction tube for the appliance runs beneath the cover sheet that is sealed in position over the wound site and into the fluid-tight enclosure provided under the cover sheet.", "An adhesive backing on the cover sheet is used to provide a fluid-tight seal around the feedthrough for the suction tube at the wound site.", "Within the enclosure, the suction tube is connected with the absorbable matrix for placement in the wound.", "The absorbable matrix functions to more uniformly apply reduced pressure or suction over the wound site while holding the cover sheet substantially out of the wound during the application of reduced pressure at the enclosed wound site.", "In another particular version of the invention, the wound treatment apparatus also includes means to monitor the temperature of the tissue in the area of the wound.", "In a particular embodiment of this version of the invention, a temperature sensitive layer composed of a temperature sensitive material is placed adjacent to the lower surface of the wound cover.", "The temperature sensitive layer changes color, or changes from one shade of a color to another shade of the same color, as the temperature of the material changes.", "In this embodiment of the invention, the wound cover is composed of a transparent or semi-transparent material allowing the temperature sensitive material to be observed from above the wound cover.", "Alternatively, the wound cover is composed of a temperature sensitive material that changes color, or changes from one shade of a color to another shade of the same color, as the temperature of the material changes.", "In another embodiment of this version of the invention, one or more temperature measuring devices are placed in the area of the wound.", "The temperature measuring devices are preferably placed adjacent to the wound tissue, but may also be placed in other locations under or above the wound cover, to monitor the temperature of said tissue.", "Temperature measuring devices located under the wound cover have leads that feedthrough beneath the wound cover.", "The leads are connected to an alarm system that produces one or more alarm signals when the temperature measured by one or more of the temperature measuring devices exceeds or is lower than a predetermined value.", "In another embodiment of this version of the invention, the temperature measuring devices are also connected through their respective leads and the alarm system to a temperature display or recording device that produces a display or record of the temperature in the area of the wound.", "In another particular version of the invention, the wound treatment apparatus is portable and self-contained.", "In this version of the invention, a miniature vacuum source is used to provide suction to the reduced pressure appliance.", "Similarly, the fluid collection system is of the minimum size desired to collect and maintain the amount of exudate expected to be aspirated from the wound during the time of anticipated use of the portable wound treatment apparatus.", "A filter may also be placed in the connection between the vacuum source and the fluid collection system to avoid contamination of the source by the fluid aspirated from the wound.", "As a result, reduced pressure treatment of a wound can continue even if it becomes necessary to transport the patient because the apparatus can accompany a patient during the transport.", "The portable apparatus is not, however, limited to this use alone.", "It can be used in any application where a portable treatment apparatus is advantageous, such as treatment of wounds in the field.", "There has thus been outlined, rather broadly, the more primary features of the present invention.", "There are additional features that are also included in the various embodiments of the invention that are described hereinafter and that form the subject matter of the claims appended hereto.", "In this respect, it is to be understood that the invention is not limited in its application to the details of construction and to the arrangements of the components set forth in the following description or illustrated in the following drawings.", "This invention may be embodied in the form illustrated in the accompanying drawings, but the drawings are illustrative only and changes may be made in the specific construction illustrated and described within the scope of the appended claims.", "The invention is capable of other embodiments and of being practiced and carried out in various ways.", "Also, it is to be understood that the phraseology and terminology employed herein are for the purpose of the description and should not be regarded as limiting." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "14/854,717, filed Sep. 15, 2015, which is a continuation of U.S. patent application Ser.", "No.", "14/142,635, filed on Dec. 27, 2013, which is a continuation of U.S. patent application Ser.", "No.", "13/302,175, filed on Nov. 22, 2011, now U.S. Pat.", "No.", "8,628,505, which is a continuation of U.S. patent application Ser.", "No.", "12/938,291, filed on Nov. 2, 2010, now U.S. Pat.", "No.", "8,118,794, which is a continuation application of U.S. patent application Ser.", "No.", "10/652,100, filed on Aug. 28, 2003, now U.S. Pat.", "No.", "7,846,141, which claims the benefit of U.S.", "Provisional Patent Application No.", "60/407,783, filed on Sep. 3, 2002, and U.S.", "Provisional Patent Application No.", "60/430,827, filed on Dec. 4, 2002, the entirety of all five of which are hereby incorporated by reference and made a part of the present disclosure as if fully set forth herein.", "BACKGROUND OF THE INVENTION Field of the Invention The present invention relates to an apparatus and a method for treating a wound by applying reduced pressure to the wound.", "In this context, the term “wound” is to be interpreted broadly, to include any body part of a patient that may be treated using reduced pressure.", "Description of the Related Art The treatment of open or chronic wounds that are too large to spontaneously close or otherwise fail to heal has long been a troublesome area of medical practice.", "Closure of an open wound requires inward migration of surrounding epithelial and subcutaneous tissue.", "Some wounds, however, are sufficiently large or infected that they are unable to heal spontaneously.", "In such instances, a zone of stasis in which localized edema restricts the flow of blood to the epithelial and subcutaneous tissue forms near the surface of the wound.", "Without sufficient blood flow, the wound is unable to successfully fight bacterial infection and is accordingly unable to close spontaneously.", "An initial stage of wound healing is characterized by the formation of granulation tissue which is a matrix of collagen, fibronectin, and hyaluronic acid carrying macrophages, fibroblasts, and neovasculature that forms the basis for subsequent epithelialization of the wound.", "Infection and poor vascularization hinder the formation of granulation tissue within wounded tissue, thereby inhibiting wound healing.", "It therefore becomes desirable to provide a technique for increasing blood circulation within wounded tissue to promote spontaneous healing and to reduce infection.", "Another problem encountered during the treatment of wounds is the selection of an appropriate technique for wound closure during the healing process.", "Sutures are often used to apply force to adjacent viable tissue in order to induce the edges of a wound to migrate together and heal.", "However, sutures apply a closure force to only a very small percentage of the area surrounding a wound.", "When there is scarring, edema, or insufficient tissue, the tension produced by the sutures can become great causing excessive pressure to be exerted by the sutures upon the tissue adjacent to each suture.", "As a result, the adjacent tissue often becomes ischemic thereby rendering suturing of large wounds counterproductive.", "If the quantity or size of the sutures is increased to reduce the tension required of any single suture, the quantity of foreign material within the wound is concomitantly increased and the wound is more apt to become infected.", "Additionally, the size or type of a particular wound may prevent the use of sutures to promote wound closure.", "It therefore becomes desirable to provide an apparatus and method for closing a large wound that distributes a closure force evenly about the periphery of the wound.", "Wounds resulting from ischemia, or lack of blood flow, are also often difficult to heal since decreased blood flow to a wound may inhibit normal immune reaction to fight infection.", "Patients that are bedridden or otherwise non-ambulatory are susceptible to such ischemic wounds as decubitus ulcers or pressure sores.", "Decubitus ulcers form as a result of constant compression of the skin surface and underlying tissue thus restricting circulation.", "Since the patient is often unable to feel the wound or to move sufficiently to relieve the pressure, such wounds can become self-perpetuating.", "Although it is common to treat such wounds with flaps, the conditions that initially caused the wound may also work against successful flap attachment.", "Wheelchair-bound paraplegics, for example, must still remain seated after treatment of pelvic pressure sores.", "It therefore becomes desirable to provide a treatment procedure for ischemic wounds that can be conducted in situ upon an immobile or partially mobile patient.", "Other types of wounds in which ischemia leads to progressive deterioration include partial thickness burns.", "A partial thickness burn is a burn in which the cell death due to thermal trauma does not extend below the deepest epidermal structures such as hair follicles, sweat glands, or sebaceous glands.", "The progression of partial thickness burns to deeper burns is a major problem in burn therapy.", "The ability to control or diminish the depth of burns greatly enhances the prognosis for burn patients and decreases morbidity resulting from burns.", "Partial thickness burns are formed of a zone of coagulation, which encompasses tissue killed by thermal injury, and a zone of stasis.", "The zone of stasis is a layer of tissue immediately beneath the zone of coagulation.", "Cells within the zone of stasis are viable, but the blood flow is static because of collapse of vascular structures due to localized edema.", "Unless blood flow is re-established within the zone of stasis soon after injury, the tissue within the zone of stasis also dies.", "The death of tissue within the zone of stasis is caused by lack of oxygen and nutrients, reperfusion injury (re-establishment of blood flow after prolonged ischemia), and decreased migration of white blood cells to the zone resulting in bacterial proliferation.", "Again, it becomes desirable to provide a technique for treating bum wounds by enhancing blood circulation to the wounded tissue to inhibit burn penetration.", "There exist various apparatus utilizing reduced pressure for treatment of these types of wounds.", "See, for example, U.S. Pat.", "No.", "5,636,643.The apparatus existing in the art is generally comprised of a fluid impermeable cover that covers the wound, which is directly or indirectly connected to a source of suction so that an area of reduced pressure is created beneath the cover in the area of the wound.", "Some type of packing material, such as gauze, is also often placed in the area of the wound beneath the cover to prevent overgrowth of the wound.", "Apparatus existing in the relevant art, however, suffer from several disadvantages.", "One such disadvantage is the necessity to change the packing material placed in the wound during the period of treatment.", "This requirement is expensive because multiple dressings are necessary and medical staff must expend time to change the dressings.", "In addition, there is an increased risk of infection and intrusion of other harmful foreign material into the wound area.", "It is therefore desirable to have a reduced pressure wound treatment system having a dressing that does not need to be changed, or needs to be changed fewer times, during the period of treatment.", "In addition, the existing apparatus do not have adequate means to monitor the pressure in the area of the wound beneath the cover.", "If the cover is not adequately sealed to the tissue surrounding the wound, reduced pressure cannot be maintained beneath the cover so that the benefits of the treatment are lost or diminished.", "In addition, pressure leaks through the seal cause the source of suction to operate more frequently, which consumes more energy and causes the suction equipment to wear faster than it would otherwise, reducing its useful life.", "Further, the flow of air into the wound area as a result of such leaks can result in increased risk of infection and intrusion of other harmful foreign material into the wound area.", "It is therefore desirable to have a relatively inexpensive means of monitoring the pressure level beneath the cover at the site of the wound.", "In addition, the existing apparatus do not have a means to determine the amount of blood flow to the tissue at the site of the wound.", "As discussed above, adequate blood circulation in the area of the wound is essential for the healing process to proceed as desired.", "Areas of tissue having an increased level of blood circulation generally have a higher temperature than areas that have a comparatively lower level of blood circulation.", "It is therefore desirable to have a means of monitoring the relative temperature within the area of the wound.", "Finally, it is sometimes necessary to transport patients in need of reduced pressure wound care.", "It is also sometimes necessary to provide reduced pressure treatment in the field.", "It is therefore also desirable to have a wound treatment apparatus that is portable and self-contained, which can accompany the patient during such transport or be used to provide reduced pressure treatment in the field.", "SUMMARY The present invention is directed to a reduced pressure wound treatment apparatus and method that satisfy the needs described above.", "As described in greater detail below, it has many advantages over existing apparatus when used for its intended purpose, as well as novel features that result in a new reduced pressure wound treatment apparatus and method that are not anticipated, rendered obvious, suggested, or even implied by any of the prior art apparatuses, either alone or in any combination thereof.", "In accordance with the present invention a wound treatment apparatus is provided for treating a wound by applying reduced pressure (i.e.", "pressure that is below ambient atmospheric pressure) to the wound in a controlled manner for a selected time period in a manner that overcomes the disadvantages of currently existing apparatus.", "The application of reduced pressure to a wound provides such benefits as faster healing, increased formation of granulation tissue, closure of chronic open wounds, reduction of bacterial density within wounds, inhibition of burn penetration, and enhancement of flap and graft attachment.", "Wounds that have exhibited positive response to treatment by the application of negative pressure include infected open wounds, decubitus ulcers, dehisced incisions, partial thickness burns, and various lesions to which flaps or grafts have been attached.", "The wound treatment apparatus in accordance with the present invention includes a reduced pressure application appliance that is applied to a treatment site at which there is a wound and normal tissue surrounding the wound.", "The reduced pressure application appliance includes a fluid impermeable wound cover for covering and enclosing the wound.", "In a particular embodiment of the present invention, the wound cover also includes means for visually monitoring the pressure in the area of the site of the wound beneath the wound cover.", "These means include a plurality of protrusions on the surface of the cover that are recessed when a predetermined pressure is present beneath the cover, but are increasingly displaced above the remaining surface of the cover as the pressure beneath the cover increases above a predetermined pressure.", "In a similar manner, the cover may contain areas that are displaced as protrusions away from the remaining surface of the cover toward the wound when reduced pressure is applied beneath the cover, and the displacement of the protrusions decreases as the pressure beneath the cover increases.", "The protrusions may also be a different color (or a different shade of the same color) from that on the remaining surface of the cover.", "In addition, the protrusions may produce a noise as they are displaced away from the remaining surface of the cover, providing an audible indication that the pressure beneath the cover is increasing.", "The appliance also includes sealing means for sealing the wound cover to the surrounding tissue of the wound in order to maintain reduced pressure in the vicinity of the wound during wound treatment.", "When the wound cover is sealed in position over the wound site, a generally fluid-tight or gas-tight sealed enclosure is formed over the wound site.", "The sealing means may be in the form of an adhesive applied to the underside of the wound cover for sealing the wound cover around the periphery of the wound.", "The sealing means may also include a separate sealing member such as an adhesive strip or a sealing ring in the form of a tubular pad or inflatable cuff secured to the wound cover for positioning around the periphery of the wound.", "In selected embodiments, the reduced pressure within the sealed enclosure under the wound cover may serve to seal the wound cover in position at the wound site.", "The reduced pressure appliance also includes a suction port for supplying reduced pressure within the sealed volume enclosed beneath the wound cover.", "The suction port may be in the form of a nipple on the wound cover.", "Alternatively, the suction port may be in the form of a tube attached to the wound cover or provided as a feedthrough beneath the wound cover.", "The appliance may also include an absorbable matrix for placement in the wound in order to encourage tissue in the area of the wound to grow into the matrix during treatment.", "The absorbable matrix is constructed of an absorbable material that is absorbed into the epithelial and subcutaneous tissue in the wound as the wound heals.", "The matrix may vary in thickness and rigidity, and it may be desirable to use a spongy absorbable material for the patient's comfort if the patient must lie upon the appliance during treatment.", "The matrix may also be perforated and constructed in a sponge-type or foam-type structure to enhance gas flow and to reduce the weight of the matrix.", "Because of the absorbable nature of the absorbable matrix, the matrix should require less frequent changing than other dressing types during the treatment process.", "In other circumstances, the matrix may not need to be changed at all during the treatment process.", "A vacuum system is connected with the reduced pressure appliance in order to provide suction or reduced pressure to the appliance.", "For this purpose, the vacuum system includes a suction pump or suction device for connection with the suction port of the appliance for producing the reduced pressure over the wound site.", "The vacuum system may include a section of hose or tube, such as a vacuum hose, that interconnects the suction device with the suction port of the appliance to provide the reduced pressure at the wound site.", "A fluid collection system may be provided intermediate the vacuum hose of the suction device and the suction port of the appliance to trap any exudate that may be aspirated from the wound by the negative pressure appliance.", "A stop mechanism may also be provided for the vacuum system to halt production of the reduced pressure at the wound site in the event that an excessive quantity of exudate has been collected.", "The apparatus may also include a control device for controlling the pump.", "In a particular embodiment of the invention, the wound cover for the reduced pressure appliance may be in the form of a gas impermeable covering sheet of flexible polymer material, such as polyethylene, having an adhesive backing that provides the seal for securing the sheet over the wound site to provide a gas-tight or fluid-tight sealed enclosure over the wound site.", "The vacuum system of the wound treatment apparatus may include a suction pump having a vacuum hose that is connected with a suction tube serving as a suction port for the appliance.", "The suction tube for the appliance runs beneath the cover sheet that is sealed in position over the wound site and into the fluid-tight enclosure provided under the cover sheet.", "An adhesive backing on the cover sheet is used to provide a fluid-tight seal around the feedthrough for the suction tube at the wound site.", "Within the enclosure, the suction tube is connected with the absorbable matrix for placement in the wound.", "The absorbable matrix functions to more uniformly apply reduced pressure or suction over the wound site while holding the cover sheet substantially out of the wound during the application of reduced pressure at the enclosed wound site.", "In another particular version of the invention, the wound treatment apparatus also includes means to monitor the temperature of the tissue in the area of the wound.", "In a particular embodiment of this version of the invention, a temperature sensitive layer composed of a temperature sensitive material is placed adjacent to the lower surface of the wound cover.", "The temperature sensitive layer changes color, or changes from one shade of a color to another shade of the same color, as the temperature of the material changes.", "In this embodiment of the invention, the wound cover is composed of a transparent or semi-transparent material allowing the temperature sensitive material to be observed from above the wound cover.", "Alternatively, the wound cover is composed of a temperature sensitive material that changes color, or changes from one shade of a color to another shade of the same color, as the temperature of the material changes.", "In another embodiment of this version of the invention, one or more temperature measuring devices are placed in the area of the wound.", "The temperature measuring devices are preferably placed adjacent to the wound tissue, but may also be placed in other locations under or above the wound cover, to monitor the temperature of said tissue.", "Temperature measuring devices located under the wound cover have leads that feedthrough beneath the wound cover.", "The leads are connected to an alarm system that produces one or more alarm signals when the temperature measured by one or more of the temperature measuring devices exceeds or is lower than a predetermined value.", "In another embodiment of this version of the invention, the temperature measuring devices are also connected through their respective leads and the alarm system to a temperature display or recording device that produces a display or record of the temperature in the area of the wound.", "In another particular version of the invention, the wound treatment apparatus is portable and self-contained.", "In this version of the invention, a miniature vacuum source is used to provide suction to the reduced pressure appliance.", "Similarly, the fluid collection system is of the minimum size desired to collect and maintain the amount of exudate expected to be aspirated from the wound during the time of anticipated use of the portable wound treatment apparatus.", "A filter may also be placed in the connection between the vacuum source and the fluid collection system to avoid contamination of the source by the fluid aspirated from the wound.", "As a result, reduced pressure treatment of a wound can continue even if it becomes necessary to transport the patient because the apparatus can accompany a patient during the transport.", "The portable apparatus is not, however, limited to this use alone.", "It can be used in any application where a portable treatment apparatus is advantageous, such as treatment of wounds in the field.", "There has thus been outlined, rather broadly, the more primary features of the present invention.", "There are additional features that are also included in the various embodiments of the invention that are described hereinafter and that form the subject matter of the claims appended hereto.", "In this respect, it is to be understood that the invention is not limited in its application to the details of construction and to the arrangements of the components set forth in the following description or illustrated in the following drawings.", "This invention may be embodied in the form illustrated in the accompanying drawings, but the drawings are illustrative only and changes may be made in the specific construction illustrated and described within the scope of the appended claims.", "The invention is capable of other embodiments and of being practiced and carried out in various ways.", "Also, it is to be understood that the phraseology and terminology employed herein are for the purpose of the description and should not be regarded as limiting.", "BRIEF DESCRIPTION OF THE DRAWINGS The foregoing summary, as well as the following detailed description of the preferred embodiments of the present invention, will be better understood when read in conjunction with the appended drawings, in which: FIG.", "1 is a schematic elevational view of a wound treatment apparatus in accordance with a particular embodiment of the present invention in which a reduced pressure appliance, shown in partial section, includes a flexible, fluid impermeable wound cover sealed over the wound and an absorbable matrix positioned in the wound, and in which a vacuum system provides reduced pressure within the wound cover of the appliance; FIG.", "2a is a schematic sectional elevational view of the reduced pressure appliance of FIG.", "1, illustrating an absorbable matrix having three layers of absorbable material, such layers being of different absorbable materials; FIG.", "2b is a schematic sectional elevational view of the reduced pressure appliance of FIG.", "1, illustrating an absorbable matrix having generally concentric layers of absorbable material, such layers being of different absorbable materials; FIG.", "3 is a schematic sectional elevational view of a reduced pressure appliance in accordance with another embodiment of the present invention, shown in partial section, in which the reduced pressure appliance includes a rigid, fluid impermeable, cone-shaped wound cover overlying the wound site; FIG.", "4a is a schematic elevational view of a wound treatment apparatus in accordance with a particular embodiment of the present invention in which a reduced pressure appliance, shown in partial section, includes a flexible, fluid impermeable wound cover sealed over the wound and an absorbable matrix positioned in the wound, and in which a vacuum system provides reduced pressure within the wound cover of the appliance; FIG.", "4b is a sectional elevational detailed view of the shutoff mechanism portion of the collection system of FIG.", "4a; FIG.", "5a is a schematic sectional elevational view of a reduced pressure appliance in accordance with another embodiment of the present invention, shown in partial section, in which the reduced pressure appliance includes a flexible, fluid impermeable wound cover sealed over the wound, said cover having embedded within it protrusions that are displaced above the remaining surface of the cover; FIG.", "5b is a detailed perspective view of a protrusion from the reduced pressure appliance of FIG.", "5a, in the fully displaced configuration; FIG.", "5c is a schematic sectional elevational view of the reduced pressure appliance of FIG.", "5a, illustrating the cover having the protrusions in the depressed configuration when sufficient vacuum is present beneath the cover; FIG.", "5d is a detailed perspective view of a protrusion from the reduced pressure appliance of FIG.", "5a, in the fully depressed configuration; FIG.", "5e is a schematic sectional elevational view of the reduced pressure appliance of FIG.", "5a, illustrating alternative protrusions having a bellows-type of configuration; FIG.", "5f is a perspective view of the reduced pressure appliance of FIG.", "5a, illustrating a pattern of protrusions on the wound cover; FIG.", "6 is a schematic sectional elevational view of a reduced pressure appliance in accordance with another embodiment of the present invention, shown in partial section, in which the reduced pressure appliance includes a packing material or an absorbable matrix positioned in the wound, and a flexible, fluid impermeable wound cover sealed over the wound, and a layer of temperature sensitive material located between the cover and the wound; FIG.", "7 is a schematic sectional elevational view of a reduced pressure appliance in accordance with another embodiment of the present invention, shown in partial section, in which the reduced pressure appliance includes a packing material positioned in the wound, and a flexible, fluid impermeable wound cover sealed over the wound, and a plurality of temperature sensors located at and surrounding the site of the wound, and in which an alarm system and a temperature display and recording device are connected to the temperature sensors; FIG.", "8a is a perspective view of a wound treatment apparatus in accordance with another embodiment of the present invention, shown from above, in which a reduced pressure appliance, a vacuum source, a filter, and a fluid collection system are connected together as a compact and portable apparatus; and FIG.", "8b is a sectional elevational detailed view of the shutoff mechanism portion of the collection system of FIG.", "8a.", "DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT In accordance with the present invention, a wound treatment apparatus is provided for treating a wound by application of reduced pressure (i.e., below atmospheric pressure) so that suction may be applied to a wound site 25 in a controlled manner for a selected period of time.", "FIG.", "1 schematically shows one version of the wound treatment apparatus, generally designated 20, which includes a reduced pressure appliance, generally designated 30, for enclosing a wound site 25 to provide a fluid-tight or gas-tight enclosure over the wound site 25 to effect treatment of a wound 25 with reduced or negative pressure.", "For the purpose of creating suction within the appliance 30, the appliance 30 is connected with a vacuum system, generally designated 50, to provide a source of suction or reduced pressure for the sealed appliance 30 at the wound site 25.Intermediate the appliance 30 and the vacuum system 50 is a fluid collection system, generally designated 70, for intercepting and retaining exudate that is aspirated from the wound site 25.FIG.", "1 also illustrates one embodiment of the reduced pressure appliance 30, which includes an absorbable matrix 32 that is placed within the wound 25, a fluid impermeable wound cover 40, and a suction port in the form of hollow tubing 45 that connects the appliance 30 to the vacuum system 50 (through the collection system 70) to provide reduced pressure in the area beneath the cover 40 in the area of the wound 25.FIG.", "1 also illustrates one embodiment of an absorbable matrix 32, which is placed within the wound 25.The absorbable matrix 32 is placed over substantially the expanse of the wound 25 to encourage growth of tissue in the area of the wound 25 into the matrix 32 as the wound heals.", "The size and configuration of the absorbable matrix 32 can be adjusted to fit the individual wound 25.It can be formed from a variety of absorbable materials, preferably a material that is also porous.", "The matrix 32 should be constructed in a manner so that it is sufficiently porous to allow oxygen to reach the wound 25.The absorbable matrix 32 is preferably constructed of a non-toxic material that is absorbable by the epithelial and subcutaneous tissue within the area of the wound 25, such as collogens derived from healthy mammals, absorbable synthetic polymers, or other materials similar to those used for absorbable dressings.", "An example is a dehydrating material derived from seaweed for treatment of exudating wounds.", "The matrix 32 may vary in thickness and rigidity, although it may be desirable to use a spongy or layered, non-woven absorbable material for the patient's comfort if the patient must lie upon the appliance 30 during treatment.", "The matrix 32 may also be perforated and constructed in a foam-type, sponge-type, or non-woven layered structure to enhance gas flow and to reduce the weight of the appliance 30.As shown in FIG.", "1, the matrix 32 is cut to an appropriate shape and size to fit within the wound 25.Alternatively, the matrix 32 may be sufficiently large to overlap the surrounding skin 24.Further, the matrix 32 may be of uniform thickness over its entire area, as is the case where monitoring the temperature of tissue in the area of the wound is desired as a part of the treatment process.", "In another embodiment of the invention, the absorbable matrix 32 has the same features as described above and as illustrated in FIG.", "1, but may also be constructed of more than one absorbable material, such material having different rates of absorption into body tissue.", "By preselecting the materials of the matrix 32, and placing them in areas of the wound 25 in which different rates of absorption are desired, it may be possible to enhance wound healing.", "An example of this embodiment of the absorbable matrix 32 is illustrated in FIG.", "2a, where the matrix 32 is composed of three layers, each layer being composed of an absorbable material different from the material in the adjacent layer.", "Thus, in a matrix 32 of three layers having the lowest layer 33 being constructed of an absorbable material, and the middle layer 34 of the matrix 32 being constructed of a material having a lower rate of absorption than the lowest layer 33, and the layer of the matrix 32 closest to the cover 40 (i.e., the highest layer 35) being constructed of a material having a rate of absorption lower than the other two layers, the area of the wound 25 adjacent to the lowest layer 26 would be allowed to close at a faster rate than the area of the wound 25 adjacent to the middle layer 27, and the area of the wound 25 adjacent to the highest layer 28 would be allowed to close at a faster rate than the area of the wound 25 adjacent to the middle layer 27 and the lowest layer 26.This embodiment of the invention is not limited to three layers or this gradation of absorption rates.", "Any combination of number of layers and absorbent materials desirable for wound treatment is possible and may be preferred.", "For example, the matrix 32 may have a highest layer 35 of absorbent material having a rate of absorption higher than the rate of absorption of the middle layer 34, which middle layer 34 has a higher rate of absorption than the rate of absorption of the lowest layer 33.Similarly, the highest layer 35 and the lowest layer 33 may have rates of absorption that are approximately equal to one another, such rate of absorption being greater or lesser than the rate of absorption of the middle layer 33.In addition, this embodiment of the matrix 32 is not limited to layers.", "The matrix 32 may be constructed in any configuration having materials of different absorption rates in any portion of the matrix 32 that is desired to promote wound healing.", "For example, as illustrated in FIG.", "2b, the material on the periphery 36 of the matrix 32 may be constructed of material having one rate of absorption, while the inner portions 37 of the matrix 32 may be constructed of one of more materials having different rates of absorption.", "This would allow for the wound 25 to close at one rate during the initial portion of the treatment period, and for the wound 25 to close at different rates during later portions of the treatment period.", "Other configurations that are possible include having approximately opposite sides or ends of the matrix 32 being constructed of a different material from the intermediate portions of the matrix 32.The fluid-impermeable wound cover 40 in the embodiment of the reduced pressure appliance 30 illustrated in FIG.", "1 is in the form of a flexible, adhesive, fluid impermeable polymer sheet for covering and enclosing the wound 25, including the absorbable matrix 32 within it, and the surrounding normal skin 24 at the wound site 25.The wound cover 40 includes an adhesive backing 41 which functions to seal the wound cover 40 to the normal skin 24 around the periphery of the wound 25 to provide a generally gas-tight or fluid-tight enclosure over the wound 25.The adhesive cover sheet 40 must have sufficient adhesion to form a fluid-tight or gas-tight seal 42 around the periphery of the wound 25 and to hold the sheet 40 in sealed contact with the skin 24 during the application of suction or reduced or negative pressure.", "The wound cover 40 also provides a gas-tight seal around the tubing 45 at the feedthrough location 46 where the tubing 45 emerges from beneath the wound cover 40.The wound cover 40 is preferably formed of a fluid impermeable or gas impermeable flexible adhesive sheet such as Ioban, a product of the 3M Corporation of Minneapolis, Minn.", "The reduced pressure appliance 30 is not, however, limited to the configuration illustrated in FIG.", "1.The appliance 30 may also have a wound cover of almost any size, shape, and configuration adapted to treat the wound.", "An example of this type of cover 40 is illustrated in the embodiment of the appliance 30 shown in FIG.", "3, which has a wound cover 140 comprised of a rigid, fluid impermeable, generally cone-shaped wound cover 140 overlying the wound site 25.Alternatively, the cover overlying the wound site may be comprised of a rigid, fluid impermeable, flat, bowl-shaped, or cup-shaped wound cover to protect the site of a wound 25 from impact or abrasion during treatment.", "The wound cover may also be comprised of a fluid impermeable, flexible cover supported by rigid support members overlying the wound site 25.All of these cover types may be sealed to the normal skin 24 surrounding the wound 25 by using the suction created under the cover and a soft and flexible padding material 143 around the periphery of the cover 140, which is in contact with the skin 24.More preferably, the cover 140 is sealed to the skin 24 using a fluid-impermeable adhesive material 141 such as an adhesive tape or an adhesive sheet that has been cut to surround and at least partially overlie the periphery of the cover 140.As an additional example, the cover may be comprised of a CPR mask, which may be sealed to the skin surrounding the wound with an inflatable air cuff that is a part of the mask, with a fluid-impermeable adhesive material, or by some other fluid-impermeable means.", "Where the cover 140 is not in contact with the absorbable matrix 32, and is therefore not exerting force adequate to keep the matrix 32 in place within the wound 25, a rigid or semi-rigid porous screen 147 may be placed over the matrix 32 and under the cover 140 in a position so that the periphery of such screen 147 is held in place by a portion of the cover 140 or the seal 142 that holds the cover 140 in place against the skin 24.In such case, the screen 147 is of a thickness and rigidity necessary to hold the matrix 32 in place within the wound 25, but having a porous structure so that fluids (including gases) are able to pass through the screen 147.The appliance 30 also includes a suction port in the form of a hollow suction tube 45 that connects with the vacuum system 50 to provide suction within the sealed enclosure.", "The suction tubing 45 serves as a suction port for the appliance 30.In the embodiment of the invention illustrated in FIG.", "1, an end segment 45a of the tubing 45 is embedded within the absorbable matrix 32 for providing suction or reduced pressure within the enclosure provided under the wound cover 40.Embedding the open end of segment 45a of tubing 45 within the interior of the absorbable matrix 32 permits the absorbable matrix 32 to function as a shield to help prevent the wound cover 40 from being inadvertently sucked into sealing engagement with the open end of the tube thereby plugging the tube 45 and restricting gas flow.", "The tube segment 45a embedded within the absorbable matrix 32 preferably has at least one side port 47 for positioning within the interior of the absorbable matrix 32 to promote substantially uniform application of reduced pressure throughout the enclosure.", "Positioning the side port 47 of tube segment 45a within the interior of the absorbable matrix 32 permits the absorbable matrix 32 to function as a shield for the side port to thereby prevent the wound cover 40 from being sucked into the side port 47 and thereby restricting gas flow.", "The open cells of the absorbable matrix 32 facilitate gas flow throughout the enclosure.", "In addition, the absorbable matrix 32 functions to encourage the growth of tissue in the area of the wound 25 into the matrix 32 and to hold the wound cover 40 generally out of contact with the wound 25 during the application of suction within the enclosure.", "Tubing 45 and tube segment 45a are sufficiently flexible to permit movement of the tubing but are sufficiently rigid to resist constriction when reduced pressure is supplied to the appliance 30 or when the location of the wound 25 is such that the patient must sit or lie upon the tubing 45 or upon the reduced pressure appliance 30.The matrix-tube assembly comprising the absorbable matrix 32 and the tube 45 may be fabricated by snaking the end of the tube segment 45a through an internal passageway in the absorbable matrix 32 such as by pulling the end of the tube segment 45a through the passageway using forceps.", "The matrix-tube assembly 32 and 45 is preferably prepared prior to use under sterile conditions and then stored in an aseptic package.", "As shown in FIG.", "4a, the vacuum system 50, which produces a source of reduced pressure or suction that is supplied to the reduced pressure appliance 30, includes a vacuum pump 51, a control device 52, a filter 53, and tubing 54 that connects the vacuum pump 51 to the collection system 70.Predetermined amounts of suction or reduced pressure are produced by the vacuum pump 51.The vacuum pump 51 is preferably controlled by a control device 52 such as a switch or a timer that may be set to provide cyclic on/off operation of the vacuum pump 51 according to user-selected intervals.", "Alternatively, the vacuum pump 51 may be operated continuously without the use of a cyclical timer.", "A filter 53 such as micropore filter is preferably attached to the exhaust of the pump 51 to prevent potentially pathogenic microbes or aerosols from being vented to atmosphere by the vacuum pump 51.As shown in FIG.", "4a, a fluid collection system, generally designated 70, is interconnected between the suction pump 51 and the appliance 30 to remove and collect any exudate which may be aspirated from the wound 25 by the reduced pressure appliance 30.The appliance 30 functions to actively draw fluid or exudate from the wound 25.Collection of exudate in a fluid collection system 70 intermediate the pump 51 and the appliance 30 is desirable to prevent clogging of the pump 51.The fluid collection system 70 is comprised of a fluid-impermeable collection container 71 and a shutoff mechanism 75.The container 71 may be of any size and shape capable of intercepting and retaining a predetermined amount of exudate.", "Many examples of such containers are available in the relevant art.", "The preferred container in this embodiment of the invention is illustrated in side elevation view in FIG.", "4a, said container having two openings in the top of the container 71.The container 71 includes a first port 72 at the top opening of the container for sealed connection to suction tubing 45.The first port 72 enables suction to be applied to the reduced pressure appliance 30 through the tubing 45 and also enables exudate from the wound 25 covered by reduced pressure appliance 30 to be drained into the container 71.The container 71 provides a means for containing and temporarily storing the collected exudate.", "A second port 73 is also provided on the top of the container to enable the application of suction from the vacuum pump 51.The second port 73 of the collection system 70 is connected to the vacuum pump 51 by a vacuum line 54.The collection system 70 is sealed generally gas-tight to enable the suction pump 51 to supply suction to the appliance 30 through the collection system 70.The container 71 may also include a fluid impenetrable flexible liner within its volume that is used to collect the exudate in a manner that avoids contaminating the container 71 with pathogenic microbes and other harmful matter present in the exudate.", "In such case, the flexible liner may be directly connected to the first port 72 and second port 73 in a manner so that no exudate comes into direct contact with the container 71.In this embodiment, the preferred liner is a flexible bag constructed of a polymer material, which is connected to the first port 72.The vacuum system 50 and collection system 70 preferably include a shutoff mechanism for halting or inhibiting the supply of the reduced pressure to the appliance 30 in the event that the exudate aspirated from the wound 25 exceeds a predetermined quantity.", "Interrupting the application of suction to the appliance 30 is desirable to prevent exsanguination in the unlikely event a blood vessel ruptures under the wound cover 40 during treatment.", "If, for example, a blood vessel ruptures in the vicinity of the wound 25, a shut-off mechanism would be useful to prevent the vacuum system 50 from aspirating any significant quantity of blood from the patient.", "The shutoff mechanism 75 may be comprised of any means that enables the vacuum system 50 to halt the supply of reduced pressure to the wound cover 40 at any time that the volume of exudate from the wound 25 exceeds a predetermined amount.", "Such means may include mechanical switches, electrical switches operably connected to the vacuum system controller 52, optical, thermal or weight sensors operably connected to the vacuum system controller 52, and any other means that are currently known in the relevant art or which may hereafter be discovered.", "The shutoff mechanism 75, as illustrated in FIG.", "4b, is preferably a float valve assembly in the form of a ball 76 which is held and suspended within a cage 77 positioned below a valve seat 78 disposed within the opening at the top of the container below the second port that will float upon the exudate and will be lifted against the valve seat 78 as the container fills with exudate.", "When the ball 76 is firmly seated against the valve seat 78, the float valve blocks the second port 73 and thereby shuts off the source of suction from the vacuum system 50.Other types of mechanisms may also be employed to detect the liquid level within the container 71 in order to arrest operation of the vacuum system 50.In another version of the invention, the wound treatment apparatus includes means to monitor the pressure beneath the wound cover 40 at the site of the wound 25.In one embodiment of this version of the invention, as illustrated in FIG.", "5a, the wound cover 40 has a plurality of protrusions 60 in the form of hills or bumps embedded in the cover 40.As illustrated in FIG.", "5a, the protrusions 60 protrude above the remaining surface 43 of the cover 40 when the cover 40 is not in use for wound treatment.", "A detailed view of a protrusion 60a in this configuration is shown in perspective view in FIG.", "5b.", "Generally, as illustrated in FIG.", "5c, in some embodiments, when the cover 40 is in use (i.e., sealed over the wound site 25 with reduced pressure applied beneath the cover 40), the protrusions 60 are displaced inwardly (or downward when the cover 40 is in the orientation depicted in FIG.", "5c) so that they are depressed to a level almost the same as that of the remaining surface 43 of the cover 40.A detailed view of a protrusion 60b in the depressed configuration is shown in perspective view in FIG.", "5d.", "In another embodiment, the protrusions 60c are configured in the form of bellows, as shown in FIG.", "5e.", "In this version of the invention, as the pressure beneath the cover 40 decreases (i.e., the level of reduced pressure increases), the top of the protrusion 60c is displaced downward toward the level of the remaining surface 43 of the cover 40.The protrusions 60 may be placed in any location, as well as in any pattern or lack of pattern, on the surface of the cover 40.An example of one possible pattern is illustrated in FIG.", "5f.", "The protrusions 60 may be constructed of the same material as the remainder of the cover 40, or may be constructed of a material different from the remainder of the cover 40, depending upon the sensitivity of pressure monitoring desired.", "Similarly, the protrusions 60 may be constructed of material having the same thickness as the remainder of the cover 40, or material of a different thickness, depending upon the sensitivity of pressure monitoring desired.", "For example, if the reduced pressure beneath the cover 40 is of a relatively low level, so that the difference between the ambient atmospheric pressure above the cover 40 is relatively small when compared to the reduced pressure beneath the cover 40, it may be desirable to have the protrusions 60 be able to change shape with relatively small changes in pressure beneath the cover 40 during the treatment period.", "In such case, it may be preferable to have the protrusions 60 of a thickness less than the thickness of the remaining cover material.", "It may also be preferable to have the protrusions 60 constructed of a material more pliable than the material of which the remainder of the cover 40 is constructed.", "Similarly, if the reduced pressure beneath the cover 40 is of a relatively high level, so that the difference between the ambient atmospheric pressure above the cover 40 is relatively large when compared to the reduced pressure beneath the cover 40, it may be desirable to have the protrusions 60 be able to change shape with relatively large changes in pressure beneath the cover 40 during the treatment period.", "In such case, it may be preferable to have the protrusions 60 of a thickness more similar to the thickness of the remaining cover material.", "It may also be preferable to have the protrusions 60 constructed of a material that is more similar to the material of which the remainder of the cover 40 is constructed in terms of pliability.", "By preselecting the thickness and pliability of the material used to construct the protrusions 60, it may also be possible to monitor the pressure by partial deflections of the protrusions 60.For example, the protrusions 60 may be displaced in an increasing amount above the remaining surface 43 of the cover 40 as the pressure beneath the cover 40 increases (i.e., the level of reduced pressure decreases).", "This relationship of displacement of the protrusions 60 to the increase in pressure beneath the cover 40 may be linear or based upon some other function.", "Similarly, the protrusions 60 may be constructed so that they only begin to be displaced when a predetermined pressure differential occurs between the area under the cover 40 and the area above the cover 40.It should be noted, however, that this version of the invention is intended as a means to provide an inexpensive and approximate visual indication of the occurrence of loss of reduced pressure beneath the cover and may not be a means to accurately measure the actual pressure beneath the cover or the actual difference between the pressure above the cover and the reduced pressure beneath the cover.", "As a result, the preferable thicknesses and materials to be used in constructing the cover 40 and protrusions 60 in this version of the invention are dependent upon a multitude of factors, including the desired pressure beneath the cover 40.Preferably, the wound cover 40 is constructed of polyurethane, having a thickness of only a few mils to ⅛th inch, and having protrusions 60 constructed of the same material as the remaining portion of the cover 40, said protrusions 60 having a thickness only slightly less than the thickness of the cover 40 to a relatively small fraction of the thickness of the cover 40.Further, the protrusions 60 may be constructed of material that is of a different color than the color of the remaining surface 43 of the cover 40.Similarly, the protrusions 60 may be of a different shade of the same color as the remaining surface 43 of the cover 40.As the protrusions 60 are displaced away from the remaining surface 43 of the cover 40, the protrusions 60 may change color as a result of the expansion of the material comprising the protrusions 60.In another embodiment of this version of the invention, the protrusions work in the manner opposite to that described above.", "In this embodiment, the cover has within it a plurality of areas that are displaced away (i.e., pulled down) from the remaining surface of the cover toward the wound when reduced pressure is applied beneath the cover.", "This downward displacement is the result of the reduced pressure suction, which causes tension that pulls the protrusions away from the remaining surface of the cover.", "As the pressure beneath the cover increases, the tension on the protrusions weakens allowing the protrusions to recede back into the cover.", "The principles discussed above with respect to thickness, materials, color, and partial deflection monitoring of pressure apply to this embodiment of the invention as well.", "It should be noted that bellows-type protrusions are not used in this embodiment.", "The protrusions 60 may also have a means whereby they produce an audible sound as the protrusions 60 are being displaced away from the remaining surface 43 of the cover 40.This sound may be produced by the “crinkling” or vibration of the material as it is displaced away from the remaining surface 43 of the cover 40.It should be noted that the means to monitor the pressure beneath the cover described in this embodiment of the invention may be used independently of any other feature of this invention.", "In addition, the means to monitor pressure beneath the cover is not limited to use in treatment of open wounds, decubitus ulcers, dehisced incisions, partial thickness burns, and various lesions to which flaps or grafts have been attached.", "Instead, said pressure monitoring means may be used in any application involving reduced pressure in the treatment of any portion of the body of a patient, such as cosmetic surgery, cosmetic healing, and prophylactic suctioning for cosmetic and psychological reasons.", "In addition, the cover may be of any configuration, including the cover configurations specifically discussed above.", "Further, it is not necessary that any packing material or matrix be present in the area of the wound beneath the cover in this version of the invention.", "Nor is it necessary that the features included in this version of the invention be included as a part of any other version or embodiment of this invention.", "In another version of the invention, the wound treatment apparatus includes means to monitor the temperature in the area of the wound 25.In one embodiment of this second version of the invention, as illustrated in FIG.", "6, a layer of temperature sensitive material 80 is placed adjacent to the lower surface 44 of the wound cover 40.Alternatively, the cover 40 and the layer 80 may be joined together to form a single integrated unit.", "In such case, the cover 40 and the layer 80 may be joined in any manner that is fluid-impermeable and allows the color (or other property exhibiting the change of temperature) of the temperature sensitive layer 80 to be observed from above the wound cover 40.The preferred means to join the cover 40 and the layer 80 is a transparent or semi-transparent adhesive material.", "Alternatively, the wound cover 40 may itself be composed of a temperature sensitive material, so that a separate temperature sensitive layer is not required.", "The temperature sensitive layer 80 (or the cover 40, if it is composed of a temperature sensitive material) may be composed of any material that changes properties in a manner that does not adversely affect the operation of the reduced pressure appliance 30.Preferably, the temperature sensitive layer 80 is composed of a material that changes color, or changes from one shade of a color to another shade of the same color, as the temperature of the material changes.", "The change in color or shade preferably occurs within the temperature range that may be expected in the area of the wound 25.In other words, the change in color or shade of the material should be significant enough to adequately indicate changes in temperature within the range of temperatures expected in the area of the wound 25.More preferably, the temperature sensitive material is a material that changes color in the range from approximately 95 degrees Fahrenheit to approximately 105 degrees Fahrenheit.", "In the embodiment of the invention shown in FIG.", "6, the temperature sensitive layer 80 is placed over a packing material or matrix 32a, which packing material or matrix 32a is placed within the area of the wound 25.The matrix 32a may be an absorbable matrix 32a, as described above.", "The packing material may be constructed of any material that is suitable for placement within a wound 25, which may be to prevent its overgrowth, but still allows for fluid and gas flow to and from the wound 25, such as a porous polymer material or gauze.", "In order to provide for uniform temperature monitoring, the packing material or matrix 32a is preferably of relatively uniform thickness when placed within the area of the wound 25.In addition, the packing material or matrix 32a should be thin enough to allow for the temperature of the tissue to affect the temperature of the temperature sensitive layer 80.More preferably, the thickness of the packing material or matrix 32a should not exceed slightly greater than zero to one half inches.", "The packing material or matrix 32a may, however, be of non-uniform thickness where the temperature sensitive layer 80 is comprised of temperature sensitive material in a manner that compensates for the differences in thickness of the packing material or matrix 32a.", "The wound cover 40 is placed over the temperature sensitive layer 80 and sealed to the normal skin 24 surrounding the wound 25.If the cover 40 and the temperature sensitive layer 80 are an integrated unit, however, the unit is placed over the packing material or matrix 32a without a separate temperature sensitive layer 80.If the cover 40 is composed of a temperature sensitive material, it is placed over the packing material or matrix without an additional temperature sensitive layer 80.It should be noted, however, that the temperature sensitive material used in this embodiment of the invention is intended as a means to provide an approximate visual indication of the temperature in the area of the wound 25 beneath the cover 4, and may not accurately measure the actual temperature beneath the cover 40.In another embodiment of this second version of the invention, one or more temperature measuring devices 81 are placed within the area of the wound 25 and connected to an alarm system, generally designated as 82.The temperature measuring devices 81 may also be connected to a temperature display and recording device 83.An example of this embodiment is illustrated in FIG.", "7, which shows temperature measuring devices 81 placed in the area of the wound 25.The temperature measuring devices 81 may be placed in any area of the wound 25 and the reduced pressure appliance 30.For example, the temperature measuring devices 81 may be placed adjacent to and in direct contact with the tissue in the area of the wound 25.Alternatively, the temperature measuring devices 81 may be embedded in any packing material or matrix 32 placed in the area of the wound 25, or in the area between such packing material or matrix 32 and the cover 40, or embedded within the cover 40, or adjacent to either surface of the cover 40.The temperature measuring devices 81 are preferably capable of measuring temperatures in the range of temperatures expected in the area of the wound 25.More preferably, the temperature measuring devices 81 are capable of measuring temperatures in the range of 95 degrees Fahrenheit to 105 degrees Fahrenheit.", "The temperature measuring devices 81 may be any device that measures temperature in the desired range and produces a corresponding signal that may be interpreted by the alarm system 82 and temperature display and recording device 83.The temperature measuring devices 81 must, however, not be harmful to body tissue.", "The temperature measuring devices 81 are preferably thermocouples or optical sensors or detectors.", "The temperature measuring devices 81 are more preferably thermocouples that generate an electronic signal representing the temperature measured by the thermocouple.", "The temperature measuring devices 81 are connected by leads 84 to an alarm system 82.The leads 84 may be in any form compatible with the temperature measuring devices 81 and the alarm system 82 and recording device 83.Preferably, the leads 84 are cables or wires constructed of an electrically conductive material, optical fiber, or other medium enabling data transmission that transfers the signals from the temperature measuring devices 81 to the alarm system 82 and the display and recording device 83.Leads 84 placed under the wound cover 40 feedthrough the seal 42 beneath the cover 40 in a manner similar to that for the tubing (as illustrated and discussed above in connection with FIG.", "1) that maintains the fluid impermeable nature of the seal 42.The alarm system 82 is comprised of a computer or other data processor 85 and an alarm device 86.The computer or data processor 85 receives the signals from the temperature measuring devices 81 and converts them to electronic or other signals that are recognized by the alarm device 86.The computer or data processor 85 is of a type that is commonly available in the relevant art.", "The alarm device 86 may produce any type of audible sound as an alarm, such as a ringing sound, buzzing, chirping or other common alarm noise.", "Alternatively, the alarm device 86 may include a digitally produced audible voice that presents predetermined messages corresponding to different temperature conditions in the area of the wound 25.The alarm device 86 preferably produces different levels of alarm depending upon the temperature measurements received from the temperature measuring devices 81.For example, as the temperature drops below or rises above successive preselected values of temperature, as measured by any temperature measuring device 81, the alarm device 86 may sound successive predetermined alarm pitches, sounds, messages or series of sounds.", "Similarly, as the temperature measured by multiple temperature measuring devices 81 successively falls below or rises above a preselected temperature, the alarm device 86 may sound successive predetermined alarm pitches, sounds, messages or series of sounds.", "The alarm system 82 may also be connected to the vacuum supply 50, so that upon production of a predetermined alarm by the alarm device 86, the vacuum pump controller 52 causes the pump 51 to cease operation.", "The computer or data processor 85 may also be connected to a temperature display and recording device 83 that records the temperatures measured by one or more of the temperature measuring devices 81.The temperature recording device 83 may be any device designed to record or display data that is compatible with the signals produced by the computer or data processor 85.Such devices are preferably devices that record data on compact disks, floppy disks, magnetic tape, integrated circuits, or other similar media in digital form or “manual” devices that record or display data in a visually depicted form, such as a chart recorder or visual electronic display, such as an LCD or CRT monitor.", "The more preferred temperature display and recording device 83 is a device recording data on a compact disk used in conjunction with an LCD monitor.", "It should be noted that in this embodiment of this version of the invention the cover 40 may be of any configuration, including the cover configuration illustrated in FIG.", "3 and the other cover configurations specifically discussed above in connection with FIG.", "3.In addition, it is not necessary that any packing material or matrix 32 be present in the area of the wound 25 beneath the cover 40 in this version of the invention.", "It is also not necessary that the temperature display and recording device 83 be included in every embodiment of this version of the invention.", "Nor is it necessary that the features included in this version of the invention be included as a part of any other version or embodiment of this invention.", "In another version of the invention, the wound treatment apparatus 220 is portable and may be self-contained.", "In a first embodiment of this version of the invention, as illustrated in FIG.", "8a, a miniature and portable vacuum source 250 is connected to a wound cover.", "The vacuum source 250 is preferably a miniature and portable vacuum pump.", "The vacuum source 250 may also be connected to a filter 253, which is connected to a collection system 270.The vacuum source 250 is used to provide suction to the reduced pressure appliance, generally designated as 230.It is portable in the sense that it is of a size small enough to be positioned directly on the surface of the wound cover 240.The vacuum source 250 is also lightweight to avoid placing too much pressure on any body part being treated by the apparatus 220 and to allow the apparatus 220 to be easily transported.", "The vacuum source 250 may be powered by electricity received through a cord plugged into a standard wall socket, or the vacuum source 250 may be powered by a battery, fuel cell, or other alternative means, such as solar or photo electric sells or a windmill or watermill operated generator.", "The vacuum source 250 may also be operated by other means, such as pneumatics or hydraulics, if such means are available.", "The wound cover 240 may be of almost any size, shape, and configuration adapted to treat the wound.", "Thus, the wound cover 240 is not limited to the embodiment illustrated in FIG.", "8a.", "As illustrated and discussed above in relation to FIG.", "3, the cover may be comprised of a rigid, fluid impermeable, cone-shaped, bowl-shaped, or cup-shaped wound cover to protect the site of a wound 25 from impact or abrasion during treatment.", "Alternatively, the cover may be comprised of a flexible or rigid flat wound cover.", "The vacuum source 250 may be attached to the cover 240 using any means that is compatible with the structure of the cover 240 and the vacuum source 250.For example, if the cover 240 is constructed of a flexible, fluid impermeable material, the vacuum source 250 may be attached to the cover 240 using an adhesive material, such as a glue or other liquid or sprayed adhesive, adhesive tape, and similar means that are currently known in the relevant art or which may hereafter be discovered.", "As another example, if the wound cover 240 is constructed of a rigid material, the vacuum source 250 may be attached to the cover 240 using a variety of fasteners and similar means, such as anchors, bolts, rivets, screws, nuts, latch and clasp, hook and loop fasteners (such as that commonly sold under the trade name VELCRO), ultrasonic welding, and similar structures that are currently known in the relevant art or which may hereafter be discovered.", "The vacuum source 250 may therefore be permanently attached to the cover 240, or the vacuum source 250 may be removably attached to the cover 240 allowing the vacuum source 250 to be reused after being used for a treatment even if the cover 240 is no longer usable after such treatment.", "The means of fastening the vacuum source 250 to the cover 240 must, however, be accomplished in a manner that allows the cover 240 to maintain the desired reduced pressure beneath the cover 240 while it is in use.", "Thus, gasket or sealant material may be used to seal any areas of perforation of the cover 240 where the fastener penetrates the surface of the cover 240.The fluid collection system 270 in the embodiment illustrated in FIG.", "8a includes a container 271 to collect the exudate and a shutoff mechanism 275, one embodiment of which is illustrated in FIG.", "8b, to halt operation of the vacuum source 250 if the level of exudate in the container 271 exceeds a predetermined level.", "The container 271 is of the minimum size desired to collect and maintain the amount of exudate expected to be aspirated from the wound during the time of anticipated use of the portable wound treatment apparatus 220.Alternatively, a small container 271 may be used, in which the fluid is changed intermittently as necessary during the treatment period.", "The container 271 has two ports, a first port 272 for connecting the container 271 to the reduced pressure appliance 230 and a second port 273 for connecting the container 271 to the vacuum source 250.A filter 253 may also be connected intermediate the vacuum source 250 and the container 271.The shutoff mechanism may be comprised of any means that enables the vacuum system 250 to halt the supply of reduced pressure to the wound cover 240 at any time the volume of exudate from the wound exceeds a predetermined amount to prevent, thereby preventing such exudate from contaminating the vacuum source 250.Such means may include mechanical switches, electrical switches operably connected to the vacuum source 250, optical, thermal or weight sensors operably connected to the vacuum source 250, and any other means that are currently known in the relevant art or which may hereafter be discovered.", "Where the shutoff mechanism transfers electrical or other data signals to the vacuum source 250, the vacuum source 250 may contain a control mechanism to convert said signals to the form necessary to halt the production of reduced pressure by the vacuum source 250.Such means is preferably the float valve shutoff mechanism 275 illustrated in FIG.", "8b, connected to the second port 273 of the container 271, which has the same features as the float valve illustrated in and discussed above in connection with FIG.", "4a.", "As illustrated in FIG.", "8a, this embodiment of the invention may also include a filter 253 to prevent potentially pathogenic microbes or aerosols from contaminating the vacuum source 250.The filter 253 is generally comprised of a filter element encased in a fluid impermeable housing that has an inlet port 256 and an outlet port 257.The filter element is preferably a hydrophobic and micropore filter capable of filtering out pathogenic microbes or aerosols.", "The housing of the filter 253 may be constructed in a manner that enables the filter element to be changed if desired.", "The filter 253 need not, however, be used in every embodiment of this version of the invention.", "In the embodiment illustrated in FIG.", "8a, tubing 245 is used to connect the reduced pressure appliance 230 covering a wound 225 to the collection system 270 by means of the first port 272 located on the container 271.The features of this tubing 245 and reduced pressure appliance 230 are substantially the same as illustrated and discussed above in connection with FIG.", "1 and FIG.", "4a.", "In addition, in the embodiment of the invention illustrated in FIG.", "8a, the second port 273 of the container 271 is connected to the inlet port 256 of the filter 253 by flexible vacuum tubing 254, such as that used to connect the collection system 270 to the reduced pressure appliance 230.This is not, however, the only means of connecting the collection system 270 to the filter 253.For example, the connection may be made by using a rigid, fluid impermeable structure, such as a short length of rigid polymer tube, permanently connecting the filter 253 and the collection system 270.The filter 253 may also be directly attached to the container 271 without the use of any tubing or other means, causing the container 271 and the filter 253 to be integrated as a single unit.", "In the embodiment of the invention illustrated in FIG.", "8a, the outlet port 257 of the filter 253 is connected to the vacuum source 250 by flexible vacuum tubing 254a, such as that used to connect the collection system 270 to the reduced pressure appliance 230.This is not, however, the only means of connecting the collection system 270 to the filter 253.For example, the connection may be made by using a rigid, fluid impermeable structure, such as a short length of rigid polymer tube permanently connecting the filter 253 and the vacuum source 250.The filter 253 may also be directly attached to the vacuum source 250 without the use of any tubing or other means, causing the container 271 and the filter 253 to be integrated as a single unit.", "As illustrated in FIG.", "8a, the vacuum source 250, the filter 253, and the container 271 may also be directly attached to one another to form a single integrated unit.", "Such attachment may be made by any of the means described above that may be used to attach the vacuum source 250 to the cover 240.Use of the wound treatment apparatus can be illustrated by a prospective example involving a reduced pressure appliance 30 of the type discussed in connection with FIG.", "1.After preparing the bed of the wound 25, one end of a length of vacuum tubing 45 is embedded in an absorbable matrix 32 that is trimmed to be the size and shape of the wound 25.The matrix 32 is saturated with saline and placed in the wound 25.As illustrated in FIG.", "7, if temperature monitoring is desired, temperature measuring devices 81 are placed in the desired locations and connected to an alarm system 82, and if desired, a display and recording device 83.Alternatively, a temperature sensitive layer 80 is placed over the matrix, as illustrated in FIG.", "6.A fluid impermeable or gas impermeable flexible adhesive sheet 40, such as IOBAN, is placed over the matrix 32 (and temperature measuring means, if utilized) and the wound 25 and sealed to the normal skin 24 surrounding the wound 25.The site of feedthrough of the vacuum tube 45 and any leads 84 from under the cover 40 is then sealed with a liquid or paste adhesive.", "Negative pressure is then applied to the reduced pressure appliance 30 by the vacuum system 50, through the intermediate fluid collection system 70.Negative pressure appliances are useful for treating a variety of wounds.", "Treatment of a wound can be carried out by securing a negative pressure appliance to the treatment site as previously shown and described, and then maintaining a substantially continuous or cyclical reduced pressure within the appliance until the wound has reached a desired improved condition.", "A selected state of improved condition may include formation of granulation tissue sufficient for the attachment of a flap or graft, reduction of microbial infection in the wound, arrest or reversal of burn penetration, closure of the wound, integration of a flap or graft with the underlying wounded tissue, complete healing of the wound, or other stages of improvement or healing appropriate to a given type of wound or wound complex.", "It may be preferable to change the appliance periodically during treatment, particularly when using appliances incorporating a packing material on or in the wound.", "The time between changing the appliance where an absorbable matrix is placed on or in the wound would ordinarily be a greater time interval that is generally dependent upon the nature of the wound.", "Where it is necessary to change the absorbable matrix during the treatment period, it may also be necessary to remove a portion of the matrix, but leave in place the portion of the matrix into which there has been significant tissue growth.", "In such cases, the portion of the matrix without significant tissue growth incorporated therein should be carefully removed by cutting or tearing away such portion from the remaining portion.", "New absorbable material can be placed in the area from which the prior material has been removed.", "The wound treatment apparatus is preferably operated using a negative or reduced pressure ranging from 0.01 to 0.99 atmospheres, and more preferably practiced using a negative or reduced pressure ranging between 0.5 to 0.8 atmospheres.", "The time period for use of the wound treatment apparatus on a wound may preferably be at least 12 hours, but can be, for example, extended for one or more days.", "There is no upper limit beyond which use of the wound treatment apparatus is no longer beneficial; use of the wound treatment apparatus increases the rate of closure up to the time the wound actually closes.", "Satisfactory treatment of various types of wounds has been obtained via the use of reduced pressures equivalent to about 2 to 7 in.", "Hg below atmospheric pressure.", "Supplying reduced pressure to the appliance in an intermittent or cyclic manner has also been demonstrated to be useful for treating wounds.", "Intermittent or cyclic supply of reduced pressure to an appliance may be achieved by manual or automatic control of the vacuum system 50.A cycle ratio, the ratio of “on” time to “off” time, in such an intermittent reduced pressure treatment may be as low as 1:10 or as high as 10:1.The preferred ratio is approximately 1:1 which is usually accomplished in alternating 5 minute intervals of reduced pressure supply and non-supply.", "A suitable vacuum system 50 includes any suction pump capable of providing at least 0.1 pounds of suction to the wound, and preferably up to three pounds suction, and most preferably up to fourteen (14) pounds suction.", "The pump can be any ordinary suction pump suitable for medical purposes that is capable of providing the necessary suction.", "The dimension of the tubing interconnecting the pump and the reduced pressure appliance is controlled by the pump's ability to provide the suction level needed for operation.", "A ¼ inch diameter tube may be suitable.", "In treating damaged tissue, use of the invention usually comprises the steps of applying negative pressure to a wound for a selected time and at a selected magnitude sufficient to reduce bacterial density in the wound.", "Open wounds are almost always contaminated with harmful bacteria.", "The application of negative pressure to a wound appears to reduce the bacterial density of the wound.", "It is believed that this effect is due to either the bacteria's incompatibility with a negative pressure environment or the increased blood flow to the wound area, as blood brings with it cells and enzymes to destroy the bacteria.", "Burns may generally be treated using a method that comprises the steps of applying negative pressure to the burn over an area with predetermined reduced pressure and for a time sufficient to inhibit formation of a full thickness burn.", "A partial thickness burn, one which has a surface layer of dead tissue and an underlying zone of stasis, is often sufficiently infected so that it will transform within 24-48 hours into a full thickness burn, one in which all epidermal structures are destroyed.", "The application of negative pressure to the wound prevents the infection from becoming sufficiently severe to cause destruction of the underlying epidermal structures.", "The magnitude, pattern, and duration of pressure application can vary with the individual wound." ] ]
Patent_15872880
[ [ "Semiconductor Chip Including Integrated Circuit Having Cross-Coupled Transistor Configuration and Method for Manufacturing the Same", "A first conductive structure forms gate electrodes of a first transistor of a first transistor type and a first transistor of a second transistor type.", "A second conductive structure forms a gate electrode of a second transistor of the first transistor type.", "A third conductive structure forms a gate electrode of a second transistor of the second transistor type.", "A fourth conductive structure forms a gate electrode of a third transistor of the first transistor type.", "A fifth conductive structure forms a gate electrode of a third transistor of the second transistor type.", "A sixth conductive structure forms gate electrodes of a fourth transistor of the first transistor type and a fourth transistor of the second transistor type.", "The second and third transistors of the first transistor type and the second and third transistors of the second transistor type are electrically connected to form a cross-coupled transistor configuration." ], [ "1.A semiconductor chip, comprising: a first conductive structure forming a gate electrode of a first transistor of a first transistor type; and a second conductive structure forming a gate electrode of a second transistor of the first transistor type, wherein both the first transistor of the first transistor type and the second transistor of the first transistor type are part of cross-coupled transistor configuration, and wherein a diffusion region of the first transistor of a first transistor type is physically separated from a diffusion region of the second transistor of the first transistor type." ], [ "<SOH> BACKGROUND <EOH>A push for higher performance and smaller die size drives the semiconductor industry to reduce circuit chip area by approximately 50% every two years.", "The chip area reduction provides an economic benefit for migrating to newer technologies.", "The 50% chip area reduction is achieved by reducing the feature sizes between 25% and 30%.", "The reduction in feature size is enabled by improvements in manufacturing equipment and materials.", "For example, improvement in the lithographic process has enabled smaller feature sizes to be achieved, while improvement in chemical mechanical polishing (CMP) has in-part enabled a higher number of interconnect layers.", "In the evolution of lithography, as the minimum feature size approached the wavelength of the light source used to expose the feature shapes, unintended interactions occurred between neighboring features.", "Today minimum feature sizes are approaching 45 nm (nanometers), while the wavelength of the light source used in the photolithography process remains at 193 nm.", "The difference between the minimum feature size and the wavelength of light used in the photolithography process is defined as the lithographic gap.", "As the lithographic gap grows, the resolution capability of the lithographic process decreases.", "An interference pattern occurs as each shape on the mask interacts with the light.", "The interference patterns from neighboring shapes can create constructive or destructive interference.", "In the case of constructive interference, unwanted shapes may be inadvertently created.", "In the case of destructive interference, desired shapes may be inadvertently removed.", "In either case, a particular shape is printed in a different manner than intended, possibly causing a device failure.", "Correction methodologies, such as optical proximity correction (OPC), attempt to predict the impact from neighboring shapes and modify the mask such that the printed shape is fabricated as desired.", "The quality of the light interaction prediction is declining as process geometries shrink and as the light interactions become more complex.", "In view of the foregoing, a solution is needed for managing lithographic gap issues as technology continues to progress toward smaller semiconductor device features sizes." ], [ "<SOH> SUMMARY <EOH>An integrated circuit including a cross-coupled transistor configuration is disclosed.", "The cross-coupled transistor configuration includes two PMOS transistors and two NMOS transistors.", "In various embodiments, gate electrodes defined in accordance with a restricted gate level layout architecture are used to form the four transistors of the cross-coupled transistor configuration.", "The gate electrodes of a first PMOS transistor and of a first NMOS transistor are electrically connected to a first gate node so as to be exposed to a substantially equivalent gate electrode voltage.", "Similarly, the gate electrodes of a second PMOS transistor and of a second NMOS transistor are electrically connected to a second gate node so as to be exposed to a substantially equivalent gate electrode voltage.", "Also, each of the four transistors of the cross-coupled transistor configuration has a respective diffusion terminal electrically connected to a common output node.", "Various embodiments of integrated circuits including the cross-coupled transistor configuration are described in the specification and drawings.", "The various embodiments include different arrangements of transistors.", "Some described embodiments also show different arrangements of conductive contacting structures and conductive interconnect structures.", "Aspects and advantages of the invention will become more apparent from the following detailed description, taken in conjunction with the accompanying drawings, illustrating by way of example the present invention." ], [ "CLAIM OF PRIORITY This application is a continuation application under 35 U.S.C.", "120 of prior U.S. application Ser.", "No.", "15/389,883, filed Dec. 23, 2016, issued as U.S. Pat.", "No.", "9,871,056, on Jan. 16, 2018, which is a continuation application under 35 U.S.C.", "120 of prior U.S. application Ser.", "No.", "14/945,361, filed Nov. 18, 2015, issued as U.S. Pat.", "No.", "9,536,899, on Jan. 3, 2017, which is a continuation application under 35 U.S.C.", "120 of prior U.S. application Ser.", "No.", "14/476,511, filed Sep. 3, 2014, issued as U.S. Pat.", "No.", "9,245,081, on Jan. 26, 2016, which is a continuation application under 35 U.S.C.", "120 of prior U.S. application Ser.", "No.", "13/741,305, filed Jan. 14, 2013, issued as U.S. Pat.", "No.", "8,872,283, on Oct. 28, 2014, which is a continuation application under 35 U.S.C.", "120 of prior U.S. application Ser.", "No.", "12/753,798, filed Apr.", "2, 2010, issued as U.S. Pat.", "No.", "8,405,163, on Mar.", "26, 2013, which is a continuation application under 35 U.S.C.", "120 of prior U.S. application Ser.", "No.", "12/402,465, filed Mar.", "11, 2009, issued as U.S. Pat.", "No.", "7,956,421, on Jun.", "7, 2011, which claims priority under 35 U.S.C.", "119(e) to each of 1) U.S.", "Provisional Patent Application No.", "61/036,460, filed Mar.", "13, 2008, 2) U.S.", "Provisional Patent Application No.", "61/042,709, filed Apr.", "4, 2008, 3) U.S.", "Provisional Patent Application No.", "61/045,953, filed Apr.", "17, 2008, and 4) U.S.", "Provisional Patent Application No.", "61/050,136, filed May 2, 2008.The disclosure of each above-identified patent application is incorporated in its entirety herein by reference.", "CROSS-REFERENCE TO RELATED APPLICATIONS This application is related to each application identified in the table below.", "The disclosure of each application identified in the table below is incorporated herein by reference in its entirety.", "Attorney Filing Docket No.", "Application No.", "Date TELAP015AC1 12/753,711 Apr.", "2, 2010 TELAP015AC2 12/753,727 Apr.", "2, 2010 TELAP015AC3 12/753,733 Apr.", "2, 2010 TELAP015AC4 12/753,740 Apr.", "2, 2010 TELAP015AC5 12/753,753 Apr.", "2, 2010 TELAP015AC6 12/753,758 Apr.", "2, 2010 TELAP015AC6A 13/741,298 Jan. 14, 2013 TELAP015AC7 12/753,766 Apr.", "2, 2010 TELAP015AC7A 13/589,028 Aug. 17, 2012 TELAP015AC8 12/753,776 Apr.", "2, 2010 TELAP015AC9 12/753,789 Apr.", "2, 2010 TELAP015AC10 12/753,793 Apr.", "2, 2010 TELAP015AC11 12/753,795 Apr.", "2, 2010 TELAP015AC12 12/753,798 Apr.", "2, 2010 TELAP015AC12A 13/741,305 Jan. 14, 2013 TELAP015AC13 12/753,805 Apr.", "2, 2010 TELAP015AC14 12/753,810 Apr.", "2, 2010 TELAP015AC15 12/753,817 Apr.", "2, 2010 TELAP015AC16 12/754,050 Apr.", "5, 2010 TELAP015AC17 12/754,061 Apr.", "5, 2010 TELAP015AC18 12/754,078 Apr.", "5, 2010 TELAP015AC19 12/754,091 Apr.", "5, 2010 TELAP015AC20 12/754,103 Apr.", "5, 2010 TELAP015AC21 12/754,114 Apr.", "5,2010 TELAP015AC22 12/754,129 Apr.", "5, 2010 TELAP015AC23 12/754,147 Apr.", "5, 2010 TELAP015AC24 12/754,168 Apr.", "5, 2010 TELAP015AC25 12/754,215 Apr.", "5, 2010 TELAP015AC26 12/754,233 Apr.", "5, 2010 TELAP015AC27 12/754,351 Apr.", "5, 2010 TELAP015AC27A 13/591,141 Aug. 21, 2012 TELAP015AC28 12/754,384 Apr.", "5, 2010 TELAP015AC29 12/754,563 Apr.", "5, 2010 TELAP015AC30 12/754,566 Apr.", "5, 2010 TELAP015AC31 13/831,530 Mar.", "14, 2013 TELAP015AC32 13/831,605 Mar.", "15, 2013 TELAP015AC33 13/831,636 Mar.", "15, 2013 TELAP015AC34 13/831,664 Mar.", "15, 2013 TELAP015AC35 13/831,717 Mar.", "15, 2013 TELAP015AC36 13/831,742 Mar.", "15, 2013 TELAP015AC37 13/831,811 Mar.", "15, 2013 TELAP015AC38 13/831,832 Mar.", "15, 2013 TELAP015AC40 14/242,308 Apr.", "1, 2014 TELAP015AC45 14/273,483 May 8, 2014 TELAP015AC46 14/303,587 Jun.", "12, 2014 TELAP015AC47 14/476,511 Sep. 3, 2014 TELAP015AC48 14/642,633 Mar.", "9, 2015 TELAP015AC49 14/945,361 Nov. 18, 2015 TELAP015AC52 15/389,883 Dec. 23, 2016 BACKGROUND A push for higher performance and smaller die size drives the semiconductor industry to reduce circuit chip area by approximately 50% every two years.", "The chip area reduction provides an economic benefit for migrating to newer technologies.", "The 50% chip area reduction is achieved by reducing the feature sizes between 25% and 30%.", "The reduction in feature size is enabled by improvements in manufacturing equipment and materials.", "For example, improvement in the lithographic process has enabled smaller feature sizes to be achieved, while improvement in chemical mechanical polishing (CMP) has in-part enabled a higher number of interconnect layers.", "In the evolution of lithography, as the minimum feature size approached the wavelength of the light source used to expose the feature shapes, unintended interactions occurred between neighboring features.", "Today minimum feature sizes are approaching 45 nm (nanometers), while the wavelength of the light source used in the photolithography process remains at 193 nm.", "The difference between the minimum feature size and the wavelength of light used in the photolithography process is defined as the lithographic gap.", "As the lithographic gap grows, the resolution capability of the lithographic process decreases.", "An interference pattern occurs as each shape on the mask interacts with the light.", "The interference patterns from neighboring shapes can create constructive or destructive interference.", "In the case of constructive interference, unwanted shapes may be inadvertently created.", "In the case of destructive interference, desired shapes may be inadvertently removed.", "In either case, a particular shape is printed in a different manner than intended, possibly causing a device failure.", "Correction methodologies, such as optical proximity correction (OPC), attempt to predict the impact from neighboring shapes and modify the mask such that the printed shape is fabricated as desired.", "The quality of the light interaction prediction is declining as process geometries shrink and as the light interactions become more complex.", "In view of the foregoing, a solution is needed for managing lithographic gap issues as technology continues to progress toward smaller semiconductor device features sizes.", "SUMMARY An integrated circuit including a cross-coupled transistor configuration is disclosed.", "The cross-coupled transistor configuration includes two PMOS transistors and two NMOS transistors.", "In various embodiments, gate electrodes defined in accordance with a restricted gate level layout architecture are used to form the four transistors of the cross-coupled transistor configuration.", "The gate electrodes of a first PMOS transistor and of a first NMOS transistor are electrically connected to a first gate node so as to be exposed to a substantially equivalent gate electrode voltage.", "Similarly, the gate electrodes of a second PMOS transistor and of a second NMOS transistor are electrically connected to a second gate node so as to be exposed to a substantially equivalent gate electrode voltage.", "Also, each of the four transistors of the cross-coupled transistor configuration has a respective diffusion terminal electrically connected to a common output node.", "Various embodiments of integrated circuits including the cross-coupled transistor configuration are described in the specification and drawings.", "The various embodiments include different arrangements of transistors.", "Some described embodiments also show different arrangements of conductive contacting structures and conductive interconnect structures.", "Aspects and advantages of the invention will become more apparent from the following detailed description, taken in conjunction with the accompanying drawings, illustrating by way of example the present invention.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1A shows an SRAM bit cell circuit, in accordance with the prior art; FIG.", "1B shows the SRAM bit cell of FIG.", "1A with the inverters expanded to reveal their respective internal transistor configurations, in accordance with the prior art; FIG.", "2 shows a cross-coupled transistor configuration, in accordance with one embodiment of the present invention; FIG.", "3A shows an example of gate electrode tracks defined within the restricted gate level layout architecture, in accordance with one embodiment of the present invention; FIG.", "3B shows the exemplary restricted gate level layout architecture of FIG.", "3A with a number of exemplary gate level features defined therein, in accordance with one embodiment of the present invention; FIG.", "4 shows diffusion and gate level layouts of a cross-coupled transistor configuration, in accordance with one embodiment of the present invention; FIG.", "5 shows a variation of the cross-coupled transistor configuration of FIG.", "4 in which the cross-coupled transistor configuration is defined on three gate electrode tracks with crossing gate electrode connections; FIG.", "6 shows a variation of the cross-coupled transistor configuration of FIG.", "4 in which the cross-coupled transistor configuration is defined on four gate electrode tracks with crossing gate electrode connections; FIG.", "7 shows a variation of the cross-coupled transistor configuration of FIG.", "4 in which the cross-coupled transistor configuration is defined on two gate electrode tracks without crossing gate electrode connections; FIG.", "8 shows a variation of the cross-coupled transistor configuration of FIG.", "4 in which the cross-coupled transistor configuration is defined on three gate electrode tracks without crossing gate electrode connections; FIG.", "9 shows a variation of the cross-coupled transistor configuration of FIG.", "4 in which the cross-coupled transistor configuration is defined on four gate electrode tracks without crossing gate electrode connections; FIG.", "10 shows a multi-level layout including a cross-coupled transistor configuration defined on three gate electrode tracks with crossing gate electrode connections, in accordance with one embodiment of the present invention; FIG.", "11 shows a multi-level layout including a cross-coupled transistor configuration defined on four gate electrode tracks with crossing gate electrode connections, in accordance with one embodiment of the present invention; FIG.", "12 shows a multi-level layout including a cross-coupled transistor configuration defined on two gate electrode tracks without crossing gate electrode connections, in accordance with one embodiment of the present invention; FIG.", "13 shows a multi-level layout including a cross-coupled transistor configuration defined on three gate electrode tracks without crossing gate electrode connections, in accordance with one embodiment of the present invention; FIG.", "14A shows a generalized multiplexer circuit in which all four cross-coupled transistors are directly connected to the common node, in accordance with one embodiment of the present invention; FIG.", "14B shows an exemplary implementation of the multiplexer circuit of FIG.", "14A with a detailed view of the pull up logic, and the pull down logic, in accordance with one embodiment of the present invention; FIG.", "14C shows a multi-level layout of the multiplexer circuit of FIG.", "14B implemented using a restricted gate level layout architecture cross-coupled transistor layout, in accordance with one embodiment of the present invention; FIG.", "15A shows the multiplexer circuit of FIG.", "14A in which two cross-coupled transistors remain directly connected to the common node, and in which two cross-coupled transistors are positioned outside the pull up logic and pull down logic, respectively, relative to the common node, in accordance with one embodiment of the present invention; FIG.", "15B shows an exemplary implementation of the multiplexer circuit of FIG.", "15A with a detailed view of the pull up logic and the pull down logic, in accordance with one embodiment of the present invention; FIG.", "15C shows a multi-level layout of the multiplexer circuit of FIG.", "15B implemented using a restricted gate level layout architecture cross-coupled transistor layout, in accordance with one embodiment of the present invention; FIG.", "16A shows a generalized multiplexer circuit in which the cross-coupled transistors are connected to form two transmission gates to the common node, in accordance with one embodiment of the present invention; FIG.", "16B shows an exemplary implementation of the multiplexer circuit of FIG.", "16A with a detailed view of the driving logic, in accordance with one embodiment of the present invention; FIG.", "16C shows a multi-level layout of the multiplexer circuit of FIG.", "16B implemented using a restricted gate level layout architecture cross-coupled transistor layout, in accordance with one embodiment of the present invention; FIG.", "17A shows a generalized multiplexer circuit in which two transistors of the four cross-coupled transistors are connected to form a transmission gate to the common node, in accordance with one embodiment of the present invention; FIG.", "17B shows an exemplary implementation of the multiplexer circuit of FIG.", "17A with a detailed view of the driving logic, in accordance with one embodiment of the present invention; FIG.", "17C shows a multi-level layout of the multiplexer circuit of FIG.", "17B implemented using a restricted gate level layout architecture cross-coupled transistor layout, in accordance with one embodiment of the present invention; FIG.", "18A shows a generalized latch circuit implemented using the cross-coupled transistor configuration, in accordance with one embodiment of the present invention; FIG.", "18B shows an exemplary implementation of the latch circuit of FIG.", "18A with a detailed view of the pull up driver logic, the pull down driver logic, the pull up feedback logic, and the pull down feedback logic, in accordance with one embodiment of the present invention; FIG.", "18C shows a multi-level layout of the latch circuit of FIG.", "18B implemented using a restricted gate level layout architecture cross-coupled transistor layout, in accordance with one embodiment of the present invention; FIG.", "19A shows the latch circuit of FIG.", "18A in which two cross-coupled transistors remain directly connected to the common node, and in which two cross-coupled transistors are positioned outside the pull up driver logic and pull down driver logic, respectively, relative to the common node, in accordance with one embodiment of the present invention; FIG.", "19B shows an exemplary implementation of the latch circuit of FIG.", "19A with a detailed view of the pull up driver logic, the pull down driver logic, the pull up feedback logic, and the pull down feedback logic, in accordance with one embodiment of the present invention; FIG.", "19C shows a multi-level layout of the latch circuit of FIG.", "19B implemented using a restricted gate level layout architecture cross-coupled transistor layout, in accordance with one embodiment of the present invention; FIG.", "20A shows the latch circuit of FIG.", "18A in which two cross-coupled transistors remain directly connected to the common node, and in which two cross-coupled transistors are positioned outside the pull up feedback logic and pull down feedback logic, respectively, relative to the common node, in accordance with one embodiment of the present invention; FIG.", "20B shows an exemplary implementation of the latch circuit of FIG.", "20A with a detailed view of the pull up driver logic, the pull down driver logic, the pull up feedback logic, and the pull down feedback logic, in accordance with one embodiment of the present invention; FIG.", "20C shows a multi-level layout of the latch circuit of FIG.", "20B implemented using a restricted gate level layout architecture cross-coupled transistor layout, in accordance with one embodiment of the present invention; FIG.", "21A shows a generalized latch circuit in which cross-coupled transistors are connected to form two transmission gates to the common node, in accordance with one embodiment of the present invention; FIG.", "21B shows an exemplary implementation of the latch circuit of FIG.", "21A with a detailed view of the driving logic and the feedback logic, in accordance with one embodiment of the present invention; FIG.", "21C shows a multi-level layout of the latch circuit of FIG.", "21B implemented using a restricted gate level layout architecture cross-coupled transistor layout, in accordance with one embodiment of the present invention; FIG.", "22A shows a generalized latch circuit in which two transistors of the four cross-coupled transistors are connected to form a transmission gate to the common node, in accordance with one embodiment of the present invention; FIG.", "22B shows an exemplary implementation of the latch circuit of FIG.", "22A with a detailed view of the driving logic, the pull up feedback logic, and the pull down feedback logic, in accordance with one embodiment of the present invention; FIG.", "22C shows a multi-level layout of the latch circuit of FIG.", "22B implemented using a restricted gate level layout architecture cross-coupled transistor layout, in accordance with one embodiment of the present invention; FIG.", "23 shows an embodiment in which two PMOS transistors of the cross-coupled transistors are respectively disposed over physically separated p-type diffusion regions, two NMOS transistors of the cross-coupled transistors are disposed over a common n-type diffusion region, and the p-type and n-type diffusion regions associated with the cross-coupled transistors are electrically connected to a common node; FIG.", "24 shows an embodiment in which two PMOS transistors of the cross-coupled transistors are disposed over a common p-type diffusion region, two NMOS transistors of the cross-coupled transistors are respectively disposed over physically separated n-type diffusion regions, and the p-type and n-type diffusion regions associated with the cross-coupled transistors are electrically connected to a common node; and FIG.", "25 shows an embodiment in which two PMOS transistors of the cross-coupled transistors are respectively disposed over physically separated p-type diffusion regions, two NMOS transistors of the cross-coupled transistors are respectively disposed over physically separated n-type diffusion regions, and the p-type and n-type diffusion regions associated with the cross-coupled transistors are electrically connected to a common node; FIGS.", "26-99, 150-157, and 168-172 illustrate various cross-coupled transistor layout embodiments in which two PMOS transistors of the cross-coupled transistors are disposed over a common p-type diffusion region, two NMOS transistors of the cross-coupled transistors are disposed over a common n-type diffusion region, and the p-type and n-type diffusion regions associated with the cross-coupled transistors are electrically connected to a common node; FIGS.", "45A-45B show annotated versions of FIG.", "45; FIGS.", "51A-51B show annotated versions of FIG.", "51; FIGS.", "59A-59B show annotated versions of FIG.", "59; FIGS.", "68A-68C show annotated versions of FIG.", "68; FIGS.", "156A-156B show annotated versions of FIG.", "156; FIGS.", "157A-157B show annotated versions of FIG.", "157; FIGS.", "170A-170B show annotated versions of FIG.", "170; FIGS.", "103, 105, 112-149, 167, 184, and 186 illustrate various cross-coupled transistor layout embodiments in which two PMOS transistors of the cross-coupled transistors are respectively disposed over physically separated p-type diffusion regions, two NMOS transistors of the cross-coupled transistors are disposed over a common n-type diffusion region, and the p-type and n-type diffusion regions associated with the cross-coupled transistors are electrically connected to a common node; FIGS.", "158-166, 173-183, 185, and 187-191 illustrate various cross-coupled transistor layout embodiments in which two PMOS transistors of the cross-coupled transistors are respectively disposed over physically separated p-type diffusion regions, two NMOS transistors of the cross-coupled transistors are respectively disposed over physically separated n-type diffusion regions, and the p-type and n-type diffusion regions associated with the cross-coupled transistors are electrically connected to a common node; FIGS.", "100, 101, 102, 104, and 106-111 show exemplary cross-coupled transistor layouts in which the n-type and p-type diffusion regions of the cross-coupled transistors are shown to be electrically connected to a common node; FIGS.", "109A-109C show annotated versions of FIG.", "109; FIGS.", "111A-111B show annotated versions of FIG.", "111; and FIG.", "192 shows another exemplary cross-couple transistor layout in which the common diffusion node shared between the cross-coupled transistors 16601p, 16603p, 16605p, and 16607p has one or more transistors defined thereover.", "DETAILED DESCRIPTION In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention.", "It will be apparent, however, to one skilled in the art that the present invention may be practiced without some or all of these specific details.", "In other instances, well known process operations have not been described in detail in order not to unnecessarily obscure the present invention.", "SRAM Bit Cell Configuration: FIG.", "1A shows an SRAM (Static Random Access Memory) bit cell circuit, in accordance with the prior art.", "The SRAM bit cell includes two cross-coupled inverters 106 and 102.Specifically, an output 106B of inverter 106 is connected to an input 102A of inverter 102, and an output 102B of inverter 102 is connected to an input 106A of inverter 106.The SRAM bit cell further includes two NMOS pass transistors 100 and 104.The NMOS pass transistor 100 is connected between a bit-line 103 and a node 109 corresponding to both the output 106B of inverter 106 and the input 102A of inverter 102.The NMOS pass transistor 104 is connected between a bit-line 105 and a node 111 corresponding to both the output 102B of inverter 102 and the input 106A of inverter 106.Also, the respective gates of NMOS pass transistors 100 and 104 are each connected to a word line 107, which controls access to the SRAM bit cell through the NMOS pass transistors 100 and 104.The SRAM bit cell requires bi-directional write, which means that when bit-line 103 is driven high, bit-line 105 is driven low, vice-versa.", "It should be understood by those skilled in the art that a logic state stored in the SRAM bit cell is maintained in a complementary manner by nodes 109 and 111.FIG.", "1B shows the SRAM bit cell of FIG.", "1A with the inverters 106 and 102 expanded to reveal their respective internal transistor configurations, in accordance with the prior art.", "The inverter 106 include a PMOS transistor 115 and an NMOS transistor 113.The respective gates of the PMOS and NMOS transistors 115, 113 are connected together to form the input 106A of inverter 106.Also, each of PMOS and NMOS transistors 115, 113 have one of their respective terminals connected together to form the output 106B of inverter 106.A remaining terminal of PMOS transistor 115 is connected to a power supply 117.A remaining terminal of NMOS transistor 113 is connected to a ground potential 119.Therefore, PMOS and NMOS transistors 115, 113 are activated in a complementary manner.", "When a high logic state is present at the input 106A of the inverter 106, the NMOS transistor 113 is turned on and the PMOS transistor 115 is turned off, thereby causing a low logic state to be generated at output 106B of the inverter 106.When a low logic state is present at the input 106A of the inverter 106, the NMOS transistor 113 is turned off and the PMOS transistor 115 is turned on, thereby causing a high logic state to be generated at output 106B of the inverter 106.The inverter 102 is defined in an identical manner to inverter 106.The inverter 102 include a PMOS transistor 121 and an NMOS transistor 123.The respective gates of the PMOS and NMOS transistors 121, 123 are connected together to form the input 102A of inverter 102.Also, each of PMOS and NMOS transistors 121, 123 have one of their respective terminals connected together to form the output 102B of inverter 102.A remaining terminal of PMOS transistor 121 is connected to the power supply 117.A remaining terminal of NMOS transistor 123 is connected to the ground potential 119.Therefore, PMOS and NMOS transistors 121, 123 are activated in a complementary manner.", "When a high logic state is present at the input 102A of the inverter 102, the NMOS transistor 123 is turned on and the PMOS transistor 121 is turned off, thereby causing a low logic state to be generated at output 102B of the inverter 102.When a low logic state is present at the input 102A of the inverter 102, the NMOS transistor 123 is turned off and the PMOS transistor 121 is turned on, thereby causing a high logic state to be generated at output 102B of the inverter 102.Cross-Coupled Transistor Configuration: FIG.", "2 shows a cross-coupled transistor configuration, in accordance with one embodiment of the present invention.", "The cross-coupled transistor configuration includes four transistors: a PMOS transistor 401, an NMOS transistor 405, a PMOS transistor 403, and an NMOS transistor 407.The PMOS transistor 401 has one terminal connected to pull up logic 209A, and its other terminal connected to a common node 495.The NMOS transistor 405 has one terminal connected to pull down logic 211A, and its other terminal connected to the common node 495.The PMOS transistor 403 has one terminal connected to pull up logic 209B, and its other terminal connected to the common node 495.The NMOS transistor 407 has one terminal connected to pull down logic 211B, and its other terminal connected to the common node 495.Respective gates of the PMOS transistor 401 and the NMOS transistor 407 are both connected to a gate node 491.Respective gates of the NMOS transistor 405 and the PMOS transistor 403 are both connected to a gate node 493.The gate nodes 491 and 493 are also referred to as control nodes 491 and 493, respectively.", "Moreover, each of the common node 495, the gate node 491, and the gate node 493 can be referred to as an electrical connection 495, 491, 493, respectively.", "Based on the foregoing, the cross-coupled transistor configuration includes four transistors: 1) a first PMOS transistor, 2) a first NMOS transistor, 3) a second PMOS transistor, and 4) a second NMOS transistor.", "Furthermore, the cross-coupled transistor configuration includes three required electrical connections: 1) each of the four transistors has one of its terminals connected to a same common node, 2) gates of one PMOS transistor and one NMOS transistor are both connected to a first gate node, and 3) gates of the other PMOS transistor and the other NMOS transistor are both connected to a second gate node.", "It should be understood that the cross-coupled transistor configuration of FIG.", "2 represents a basic configuration of cross-coupled transistors.", "In other embodiments, additional circuitry components can be connected to any node within the cross-coupled transistor configuration of FIG.", "2.Moreover, in other embodiments, additional circuitry components can be inserted between any one or more of the cross-coupled transistors (401, 405, 403, 407) and the common node 495, without departing from the cross-coupled transistor configuration of FIG.", "2.Difference Between SRAM Bit Cell and Cross-Coupled Transistor Configurations: It should be understood that the SRAM bit cell of FIGS.", "1A-1B does not include a cross-coupled transistor configuration.", "In particular, it should be understood that the cross-coupled “inverters” 106 and 102 within the SRAM bit cell neither represent nor infer a cross-coupled “transistor” configuration.", "As discussed above, the cross-coupled transistor configuration requires that each of the four transistors has one of its terminals electrically connected to the same common node.", "This does not occur in the SRAM bit cell.", "With reference to the SRAM bit cell in FIG.", "1B, the terminals of PMOS transistor 115 and NMOS transistor 113 are connected together at node 109, but the terminals of PMOS transistor 121 and NMOS transistor 123 are connected together at node 111.More specifically, the terminals of PMOS transistor 115 and NMOS transistor 113 that are connected together at the output 106B of the inverter are connected to the gates of each of PMOS transistor 121 and NMOS transistor 123, and therefore are not connected to both of the terminals of PMOS transistor 121 and NMOS transistor 123.Therefore, the SRAM bit cell does not include four transistors (two PMOS and two NMOS) that each have one of its terminals connected together at a same common node.", "Consequently, the SRAM bit cell does represent or include a cross-coupled transistor configuration, such as described with regard to FIG.", "2.Restricted Gate Level Layout Architecture: The present invention implements a restricted gate level layout architecture within a portion of a semiconductor chip.", "For the gate level, a number of parallel virtual lines are defined to extend across the layout.", "These parallel virtual lines are referred to as gate electrode tracks, as they are used to index placement of gate electrodes of various transistors within the layout.", "In one embodiment, the parallel virtual lines which form the gate electrode tracks are defined by a perpendicular spacing therebetween equal to a specified gate electrode pitch.", "Therefore, placement of gate electrode segments on the gate electrode tracks corresponds to the specified gate electrode pitch.", "In another embodiment the gate electrode tracks are spaced at variable pitches greater than or equal to a specified gate electrode pitch.", "FIG.", "3A shows an example of gate electrode tracks 301A-301E defined within the restricted gate level layout architecture, in accordance with one embodiment of the present invention.", "Gate electrode tracks 301A-301E are formed by parallel virtual lines that extend across the gate level layout of the chip, with a perpendicular spacing therebetween equal to a specified gate electrode pitch 307.For illustrative purposes, complementary diffusion regions 303 and 305 are shown in FIG.", "3A.", "It should be understood that the diffusion regions 303 and 305 are defined in the diffusion level below the gate level.", "Also, it should be understood that the diffusion regions 303 and 305 are provided by way of example and in no way represent any limitation on diffusion region size, shape, and/or placement within the diffusion level relative to the restricted gate level layout architecture.", "Within the restricted gate level layout architecture, a gate level feature layout channel is defined about a given gate electrode track so as to extend between gate electrode tracks adjacent to the given gate electrode track.", "For example, gate level feature layout channels 301A-1 through 301E-1 are defined about gate electrode tracks 301A through 301E, respectively.", "It should be understood that each gate electrode track has a corresponding gate level feature layout channel.", "Also, for gate electrode tracks positioned adjacent to an edge of a prescribed layout space, e.g., adjacent to a cell boundary, the corresponding gate level feature layout channel extends as if there were a virtual gate electrode track outside the prescribed layout space, as illustrated by gate level feature layout channels 301A-1 and 301E-1.It should be further understood that each gate level feature layout channel is defined to extend along an entire length of its corresponding gate electrode track.", "Thus, each gate level feature layout channel is defined to extend across the gate level layout within the portion of the chip to which the gate level layout is associated.", "Within the restricted gate level layout architecture, gate level features associated with a given gate electrode track are defined within the gate level feature layout channel associated with the given gate electrode track.", "A contiguous gate level feature can include both a portion which defines a gate electrode of a transistor, and a portion that does not define a gate electrode of a transistor.", "Thus, a contiguous gate level feature can extend over both a diffusion region and a dielectric region of an underlying chip level.", "In one embodiment, each portion of a gate level feature that forms a gate electrode of a transistor is positioned to be substantially centered upon a given gate electrode track.", "Furthermore, in this embodiment, portions of the gate level feature that do not form a gate electrode of a transistor can be positioned within the gate level feature layout channel associated with the given gate electrode track.", "Therefore, a given gate level feature can be defined essentially anywhere within a given gate level feature layout channel, so long as gate electrode portions of the given gate level feature are centered upon the gate electrode track corresponding to the given gate level feature layout channel, and so long as the given gate level feature complies with design rule spacing requirements relative to other gate level features in adjacent gate level layout channels.", "Additionally, physical contact is prohibited between gate level features defined in gate level feature layout channels that are associated with adjacent gate electrode tracks.", "FIG.", "3B shows the exemplary restricted gate level layout architecture of FIG.", "3A with a number of exemplary gate level features 309-323 defined therein, in accordance with one embodiment of the present invention.", "The gate level feature 309 is defined within the gate level feature layout channel 301A-1 associated with gate electrode track 301A.", "The gate electrode portions of gate level feature 309 are substantially centered upon the gate electrode track 301A.", "Also, the non-gate electrode portions of gate level feature 309 maintain design rule spacing requirements with gate level features 311 and 313 defined within adjacent gate level feature layout channel 301B-1.Similarly, gate level features 311-323 are defined within their respective gate level feature layout channel, and have their gate electrode portions substantially centered upon the gate electrode track corresponding to their respective gate level feature layout channel.", "Also, it should be appreciated that each of gate level features 311-323 maintains design rule spacing requirements with gate level features defined within adjacent gate level feature layout channels, and avoids physical contact with any another gate level feature defined within adjacent gate level feature layout channels.", "A gate electrode corresponds to a portion of a respective gate level feature that extends over a diffusion region, wherein the respective gate level feature is defined in its entirety within a gate level feature layout channel.", "Each gate level feature is defined within its gate level feature layout channel without physically contacting another gate level feature defined within an adjoining gate level feature layout channel.", "As illustrated by the example gate level feature layout channels 301A-1 through 301E-1 of FIG.", "3B, each gate level feature layout channel is associated with a given gate electrode track and corresponds to a layout region that extends along the given gate electrode track and perpendicularly outward in each opposing direction from the given gate electrode track to a closest of either an adjacent gate electrode track or a virtual gate electrode track outside a layout boundary.", "Some gate level features may have one or more contact head portions defined at any number of locations along their length.", "A contact head portion of a given gate level feature is defined as a segment of the gate level feature having a height and a width of sufficient size to receive a gate contact structure, wherein “width” is defined across the substrate in a direction perpendicular to the gate electrode track of the given gate level feature, and wherein “height” is defined across the substrate in a direction parallel to the gate electrode track of the given gate level feature.", "It should be appreciated that a contact head of a gate level feature, when viewed from above, can be defined by essentially any layout shape, including a square or a rectangle.", "Also, depending on layout requirements and circuit design, a given contact head portion of a gate level feature may or may not have a gate contact defined thereabove.", "A gate level of the various embodiments disclosed herein is defined as a restricted gate level, as discussed above.", "Some of the gate level features form gate electrodes of transistor devices.", "Others of the gate level features can form conductive segments extending between two points within the gate level.", "Also, others of the gate level features may be non-functional with respect to integrated circuit operation.", "It should be understood that the each of the gate level features, regardless of function, is defined to extend across the gate level within their respective gate level feature layout channels without physically contacting other gate level features defined with adjacent gate level feature layout channels.", "In one embodiment, the gate level features are defined to provide a finite number of controlled layout shape-to-shape lithographic interactions which can be accurately predicted and optimized for in manufacturing and design processes.", "In this embodiment, the gate level features are defined to avoid layout shape-to-shape spatial relationships which would introduce adverse lithographic interaction within the layout that cannot be accurately predicted and mitigated with high probability.", "However, it should be understood that changes in direction of gate level features within their gate level layout channels are acceptable when corresponding lithographic interactions are predictable and manageable.", "It should be understood that each of the gate level features, regardless of function, is defined such that no gate level feature along a given gate electrode track is configured to connect directly within the gate level to another gate level feature defined along a different gate electrode track without utilizing a non-gate level feature.", "Moreover, each connection between gate level features that are placed within different gate level layout channels associated with different gate electrode tracks is made through one or more non-gate level features, which may be defined in higher interconnect levels, i.e., through one or more interconnect levels above the gate level, or by way of local interconnect features at or below the gate level.", "Cross-Coupled Transistor Layouts: As discussed above, the cross-coupled transistor configuration includes four transistors (2 PMOS transistors and 2 NMOS transistors).", "In various embodiments of the present invention, gate electrodes defined in accordance with the restricted gate level layout architecture are respectively used to form the four transistors of a cross-coupled transistor configuration layout.", "FIG.", "4 shows diffusion and gate level layouts of a cross-coupled transistor configuration, in accordance with one embodiment of the present invention.", "The cross-coupled transistor layout of FIG.", "4 includes the first PMOS transistor 401 defined by a gate electrode 401A extending along a gate electrode track 450 and over a p-type diffusion region 480.The first NMOS transistor 407 is defined by a gate electrode 407A extending along a gate electrode track 456 and over an n-type diffusion region 486.The second PMOS transistor 403 is defined by a gate electrode 403A extending along the gate electrode track 456 and over a p-type diffusion region 482.The second NMOS transistor 405 is defined by a gate electrode 405A extending along the gate electrode track 450 and over an n-type diffusion region 484.The gate electrodes 401A and 407A of the first PMOS transistor 401 and first NMOS transistor 407, respectively, are electrically connected to the first gate node 491 so as to be exposed to a substantially equivalent gate electrode voltage.", "Similarly, the gate electrodes 403A and 405A of the second PMOS transistor 403 and second NMOS transistor 405, respectively, are electrically connected to the second gate node 493 so as to be exposed to a substantially equivalent gate electrode voltage.", "Also, each of the four transistors 401, 403, 405, 407 has a respective diffusion terminal electrically connected to the common output node 495.The cross-coupled transistor layout can be implemented in a number of different ways within the restricted gate level layout architecture.", "In the exemplary embodiment of FIG.", "4, the gate electrodes 401A and 405A of the first PMOS transistor 401 and second NMOS transistor 405 are positioned along the same gate electrode track 450.Similarly, the gate electrodes 403A and 407A of the second PMOS transistor 403 and second NMOS transistor 407 are positioned along the same gate electrode track 456.Thus, the particular embodiment of FIG.", "4 can be characterized as a cross-coupled transistor configuration defined on two gate electrode tracks with crossing gate electrode connections.", "FIG.", "5 shows a variation of the cross-coupled transistor configuration of FIG.", "4 in which the cross-coupled transistor configuration is defined on three gate electrode tracks with crossing gate electrode connections.", "Specifically, the gate electrode 401A of the first PMOS transistor 401 is defined on the gate electrode track 450.The gate electrode 403A of the second PMOS transistor 403 is defined on the gate electrode track 456.The gate electrode 407A of the first NMOS transistor 407 is defined on a gate electrode track 456.And, the gate electrode 405A of the second NMOS transistor 405 is defined on a gate electrode track 448.Thus, the particular embodiment of FIG.", "5 can be characterized as a cross-coupled transistor configuration defined on three gate electrode tracks with crossing gate electrode connections.", "FIG.", "6 shows a variation of the cross-coupled transistor configuration of FIG.", "4 in which the cross-coupled transistor configuration is defined on four gate electrode tracks with crossing gate electrode connections.", "Specifically, the gate electrode 401A of the first PMOS transistor 401 is defined on the gate electrode track 450.The gate electrode 403A of the second PMOS transistor 403 is defined on the gate electrode track 456.The gate electrode 407A of the first NMOS transistor 407 is defined on a gate electrode track 458.And, the gate electrode 405A of the second NMOS transistor 405 is defined on a gate electrode track 454.Thus, the particular embodiment of FIG.", "6 can be characterized as a cross-coupled transistor configuration defined on four gate electrode tracks with crossing gate electrode connections.", "FIG.", "7 shows a variation of the cross-coupled transistor configuration of FIG.", "4 in which the cross-coupled transistor configuration is defined on two gate electrode tracks without crossing gate electrode connections.", "Specifically, the gate electrode 401A of the first PMOS transistor 401 is defined on the gate electrode track 450.The gate electrode 407A of the first NMOS transistor 407 is also defined on a gate electrode track 450.The gate electrode 403A of the second PMOS transistor 403 is defined on the gate electrode track 456.And, the gate electrode 405A of the second NMOS transistor 405 is also defined on a gate electrode track 456.Thus, the particular embodiment of FIG.", "7 can be characterized as a cross-coupled transistor configuration defined on two gate electrode tracks without crossing gate electrode connections.", "FIG.", "8 shows a variation of the cross-coupled transistor configuration of FIG.", "4 in which the cross-coupled transistor configuration is defined on three gate electrode tracks without crossing gate electrode connections.", "Specifically, the gate electrode 401A of the first PMOS transistor 401 is defined on the gate electrode track 450.The gate electrode 407A of the first NMOS transistor 407 is also defined on a gate electrode track 450.The gate electrode 403A of the second PMOS transistor 403 is defined on the gate electrode track 454.And, the gate electrode 405A of the second NMOS transistor 405 is defined on a gate electrode track 456.Thus, the particular embodiment of FIG.", "8 can be characterized as a cross-coupled transistor configuration defined on three gate electrode tracks without crossing gate electrode connections.", "FIG.", "9 shows a variation of the cross-coupled transistor configuration of FIG.", "4 in which the cross-coupled transistor configuration is defined on four gate electrode tracks without crossing gate electrode connections.", "Specifically, the gate electrode 401A of the first PMOS transistor 401 is defined on the gate electrode track 450.The gate electrode 403A of the second PMOS transistor 403 is defined on the gate electrode track 454.The gate electrode 407A of the first NMOS transistor 407 is defined on a gate electrode track 452.And, the gate electrode 405A of the second NMOS transistor 405 is defined on a gate electrode track 456.Thus, the particular embodiment of FIG.", "9 can be characterized as a cross-coupled transistor configuration defined on four gate electrode tracks without crossing gate electrode connections.", "It should be appreciated that although the cross-coupled transistors 401, 403, 405, 407 of FIGS.", "4-9 are depicted as having their own respective diffusion region 480, 482, 484, 486, respectively, other embodiments may utilize a contiguous p-type diffusion region for PMOS transistors 401 and 403, and/or utilize a contiguous n-type diffusion region for NMOS transistors 405 and 407.Moreover, although the example layouts of FIGS.", "4-9 depict the p-type diffusion regions 480 and 482 in a vertically aligned position, it should be understood that the p-type diffusion regions 480 and 482 may not be vertically aligned in other embodiments.", "Similarly, although the example layouts of FIGS.", "4-9 depict the n-type diffusion regions 484 and 486 in a vertically aligned position, it should be understood that the n-type diffusion regions 484 and 486 may not be vertically aligned in other embodiments.", "For example, the cross-coupled transistor layout of FIG.", "4 includes the first PMOS transistor 401 defined by the gate electrode 401A extending along the gate electrode track 450 and over a first p-type diffusion region 480.And, the second PMOS transistor 403 is defined by the gate electrode 403A extending along the gate electrode track 456 and over a second p-type diffusion region 482.The first NMOS transistor 407 is defined by the gate electrode 407A extending along the gate electrode track 456 and over a first n-type diffusion region 486.And, the second NMOS transistor 405 is defined by the gate electrode 405A extending along the gate electrode track 450 and over a second n-type diffusion region 484.The gate electrode tracks 450 and 456 extend in a first parallel direction.", "At least a portion of the first p-type diffusion region 480 and at least a portion of the second p-type diffusion region 482 are formed over a first common line of extent that extends across the substrate perpendicular to the first parallel direction of the gate electrode tracks 450 and 456.Additionally, at least a portion of the first n-type diffusion region 486 and at least a portion of the second n-type diffusion region 484 are formed over a second common line of extent that extends across the substrate perpendicular to the first parallel direction of the gate electrode tracks 450 and 456.FIG.", "14C shows that two PMOS transistors (401A and 403A) of the cross-coupled transistors are disposed over a common p-type diffusion region (PDIFF), two NMOS transistors (405A and 407A) of the cross-coupled transistors are disposed over a common n-type diffusion region (NDIFF), and the p-type (PDIFF) and n-type (NDIFF) diffusion regions associated with the cross-coupled transistors are electrically connected to a common node 495.The gate electrodes of the cross-coupled transistors (401A, 403A, 405A, 407A) extend in a first parallel direction.", "At least a portion of a first p-type diffusion region associated with the first PMOS transistor 401A and at least a portion of a second p-type diffusion region associated with the second PMOS transistor 403A are formed over a first common line of extent that extends across the substrate perpendicular to the first parallel direction of the gate electrodes.", "Additionally, at least a portion of a first n-type diffusion region associated with the first NMOS transistor 405A and at least a portion of a second n-type diffusion region associated with the second NMOS transistor 407A are formed over a second common line of extent that extends across the substrate perpendicular to the first parallel direction of the gate electrodes.", "In another embodiment, two PMOS transistors of the cross-coupled transistors are respectively disposed over physically separated p-type diffusion regions, two NMOS transistors of the cross-coupled transistors are disposed over a common n-type diffusion region, and the p-type and n-type diffusion regions associated with the cross-coupled transistors are electrically connected to a common node.", "FIG.", "23 illustrates a cross-coupled transistor layout embodiment in which two PMOS transistors (2301 and 2303) of the cross-coupled transistors are respectively disposed over physically separated p-type diffusion regions (2302 and 2304), two NMOS transistors (2305 and 2307) of the cross-coupled transistors are disposed over a common n-type diffusion region 2306, and the p-type (2302, 2304) and n-type 2306 diffusion regions associated with the cross-coupled transistors are electrically connected to a common node 2309.FIG.", "23 shows that the gate electrodes of the cross-coupled transistors (2301, 2303, 2305, 2307) extend in a first parallel direction 2311.FIG.", "23 also shows that the first 2302 and second 2304 p-type diffusion regions are formed in a spaced apart manner relative to the first parallel direction 2311 of the gate electrodes, such that no single line of extent that extends across the substrate in a direction 2313 perpendicular to the first parallel direction 2311 of the gate electrodes intersects both the first 2302 and second 2304 p-type diffusion regions.", "Also, FIG.", "23 shows that at least a portion of a first n-type diffusion region (part of 2306) associated with a first NMOS transistor 2305 and at least a portion of a second n-type diffusion region (part of 2306) associated with a second NMOS transistor 2307 are formed over a common line of extent that extends across the substrate in the direction 2313 perpendicular to the first parallel direction 2311 of the gate electrodes.", "In another embodiment, two PMOS transistors of the cross-coupled transistors are disposed over a common p-type diffusion region, two NMOS transistors of the cross-coupled transistors are respectively disposed over physically separated n-type diffusion regions, and the p-type and n-type diffusion regions associated with the cross-coupled transistors are electrically connected to a common node.", "FIG.", "24 shows the cross-coupled transistor embodiment of FIG.", "23, with the p-type (2302 and 2304) and n-type 2306 diffusion regions of FIG.", "23 reversed to n-type (2402 and 2404) and p-type 2406 diffusion regions, respectively.", "FIG.", "24 illustrates a cross-coupled transistor layout embodiment in which two PMOS transistors (2405 and 2407) of the cross-coupled transistors are disposed over a common p-type diffusion region 2406, two NMOS transistors (2401 and 2403) of the cross-coupled transistors are respectively disposed over physically separated n-type diffusion regions (2402 and 2404), and the p-type 2406 and n-type (2402 and 2404) diffusion regions associated with the cross-coupled transistors are electrically connected to a common node 2409.FIG.", "24 shows that the gate electrodes of the cross-coupled transistors (2401, 2403, 2405, 2407) extend in a first parallel direction 2411.FIG.", "24 also shows that at least a portion of a first p-type diffusion region (part of 2406) associated with a first PMOS transistor 2405 and at least a portion of a second p-type diffusion region (part of 2406) associated with a second PMOS transistor 2407 are formed over a common line of extent that extends across the substrate in a direction 2413 perpendicular to the first parallel direction 2411 of the gate electrodes.", "Also, FIG.", "24 shows that the first 2402 and second 2404 n-type diffusion regions are formed in a spaced apart manner relative to the first parallel direction 2411, such that no single line of extent that extends across the substrate in the direction 2413 perpendicular to the first parallel direction 2411 of the gate electrodes intersects both the first 2402 and second 2404 n-type diffusion regions.", "In yet another embodiment, two PMOS transistors of the cross-coupled transistors are respectively disposed over physically separated p-type diffusion regions, two NMOS transistors of the cross-coupled transistors are respectively disposed over physically separated n-type diffusion regions, and the p-type and n-type diffusion regions associated with the cross-coupled transistors are electrically connected to a common node.", "FIG.", "25 shows a cross-coupled transistor layout embodiment in which two PMOS transistors (2501 and 2503) of the cross-coupled transistors are respectively disposed over physically separated p-type diffusion regions (2502 and 2504), two NMOS transistors (2505 and 2507) of the cross-coupled transistors are respectively disposed over physically separated n-type diffusion regions (2506 and 2508), and the p-type (2502 and 2504) and n-type (2506 and 2508) diffusion regions associated with the cross-coupled transistors are electrically connected to a common node 2509.FIG.", "25 shows that the gate electrodes of the cross-coupled transistors (2501, 2503, 2505, 2507) extend in a first parallel direction 2511.FIG.", "25 also shows that the first 2502 and second 2504 p-type diffusion regions are formed in a spaced apart manner relative to the first parallel direction 2511, such that no single line of extent that extends across the substrate in a direction 2513 perpendicular to the first parallel direction 2511 of the gate electrodes intersects both the first 2502 and second 2504 p-type diffusion regions.", "Also, FIG.", "25 shows that the first 2506 and second 2508 n-type diffusion regions are formed in a spaced apart manner relative to the first parallel direction 2511, such that no single line of extent that extends across the substrate in the direction 2513 perpendicular to the first parallel direction 2511 of the gate electrodes intersects both the first 2506 and second 2508 n-type diffusion regions.", "In FIGS.", "4-9, the gate electrode connections are electrically represented by lines 491 and 493, and the common node electrical connection is represented by line 495.It should be understood that in layout space each of the gate electrode electrical connections 491, 493, and the common node electrical connection 495 can be structurally defined by a number of layout shapes extending through multiple chip levels.", "FIGS.", "10-13 show examples of how the gate electrode electrical connections 491, 493, and the common node electrical connection 495 can be defined in different embodiments.", "It should be understood that the example layouts of FIGS.", "10-13 are provided by way of example and in no way represent an exhaustive set of possible multi-level connections that can be utilized for the gate electrode electrical connections 491, 493, and the common node electrical connection 495.FIG.", "10 shows a multi-level layout including a cross-coupled transistor configuration defined on three gate electrode tracks with crossing gate electrode connections, in accordance with one embodiment of the present invention.", "The layout of FIG.", "10 represents an exemplary implementation of the cross-coupled transistor embodiment of FIG.", "5.The electrical connection 491 between the gate electrode 401A of the first PMOS transistor 401 and the gate electrode 407A of the first NMOS transistor 407 is formed by a multi-level connection that includes a gate contact 1001, a (two-dimensional) metal-1 structure 1003, and a gate contact 1005.The electrical connection 493 between the gate electrode 403A of the second PMOS transistor 403 and the gate electrode 405A of the second NMOS transistor 405 is formed by a multi-level connection that includes a gate contact 1007, a (two-dimensional) metal-1 structure 1009, and a gate contact 1011.The output node electrical connection 495 is formed by a multi-level connection that includes a diffusion contact 1013, a (two-dimensional) metal-1 structure 1015, a diffusion contact 1017, and a diffusion contact 1019.FIG.", "11 shows a multi-level layout including a cross-coupled transistor configuration defined on four gate electrode tracks with crossing gate electrode connections, in accordance with one embodiment of the present invention.", "The layout of FIG.", "11 represents an exemplary implementation of the cross-coupled transistor embodiment of FIG.", "6.The electrical connection 491 between the gate electrode 401A of the first PMOS transistor 401 and the gate electrode 407A of the first NMOS transistor 407 is formed by a multi-level connection that includes a gate contact 1101, a (two-dimensional) metal-1 structure 1103, and a gate contact 1105.The electrical connection 493 between the gate electrode 403A of the second PMOS transistor 403 and the gate electrode 405A of the second NMOS transistor 405 is formed by a multi-level connection that includes a gate contact 1107, a (one-dimensional) metal-1 structure 1109, a via 1111, a (one-dimensional) metal-2 structure 1113, a via 1115, a (one-dimensional) metal-1 structure 1117, and a gate contact 1119.The output node electrical connection 495 is formed by a multi-level connection that includes a diffusion contact 1121, a (two-dimensional) metal-1 structure 1123, a diffusion contact 1125, and a diffusion contact 1127.FIG.", "12 shows a multi-level layout including a cross-coupled transistor configuration defined on two gate electrode tracks without crossing gate electrode connections, in accordance with one embodiment of the present invention.", "The layout of FIG.", "12 represents an exemplary implementation of the cross-coupled transistor embodiment of FIG.", "7.The gate electrodes 401A and 407A of the first PMOS transistor 401 and first NMOS transistor 407, respectively, are formed by a contiguous gate level structure placed on the gate electrode track 450.Therefore, the electrical connection 491 between the gate electrodes 401A and 407A is made directly within the gate level along the single gate electrode track 450.Similarly, the gate electrodes 403A and 405A of the second PMOS transistor 403 and second NMOS transistor 405, respectively, are formed by a contiguous gate level structure placed on the gate electrode track 456.Therefore, the electrical connection 493 between the gate electrodes 403A and 405A is made directly within the gate level along the single gate electrode track 456.The output node electrical connection 495 is formed by a multi-level connection that includes a diffusion contact 1205, a (one-dimensional) metal-1 structure 1207, and a diffusion contact 1209.Further with regard to FIG.", "12, it should be noted that when the gate electrodes 401A and 407A of the first PMOS transistor 401 and first NMOS transistor 407, respectively, are formed by a contiguous gate level structure, and when the gate electrodes 403A and 405A of the second PMOS transistor 403 and second NMOS transistor 405, respectively, are formed by a contiguous gate level structure, the corresponding cross-coupled transistor layout may include electrical connections between diffusion regions associated with the four cross-coupled transistors 401, 407, 403, 405, that cross in layout space without electrical communication therebetween.", "For example, diffusion region 1220 of PMOS transistor 403 is electrically connected to diffusion region 1222 of NMOS transistor 407 as indicated by electrical connection 1224, and diffusion region 1230 of PMOS transistor 401 is electrically connected to diffusion region 1232 of NMOS transistor 405 as indicated by electrical connection 1234, wherein electrical connections 1224 and 1234 cross in layout space without electrical communication therebetween.", "FIG.", "13 shows a multi-level layout including a cross-coupled transistor configuration defined on three gate electrode tracks without crossing gate electrode connections, in accordance with one embodiment of the present invention.", "The layout of FIG.", "13 represents an exemplary implementation of the cross-coupled transistor embodiment of FIG.", "8.The gate electrodes 401A and 407A of the first PMOS transistor 401 and first NMOS transistor 407, respectively, are formed by a contiguous gate level structure placed on the gate electrode track 450.Therefore, the electrical connection 491 between the gate electrodes 401A and 407A is made directly within the gate level along the single gate electrode track 450.The electrical connection 493 between the gate electrode 403A of the second PMOS transistor 403 and the gate electrode 405A of the second NMOS transistor 405 is formed by a multi-level connection that includes a gate contact 1303, a (one-dimensional) metal-1 structure 1305, and a gate contact 1307.The output node electrical connection 495 is formed by a multi-level connection that includes a diffusion contact 1311, a (one-dimensional) metal-1 structure 1313, and a diffusion contact 1315.In one embodiment, electrical connection of the diffusion regions of the cross-coupled transistors to the common node 495 can be made using one or more local interconnect conductors defined at or below the gate level itself.", "This embodiment may also combine local interconnect conductors with conductors in higher levels (above the gate level) by way of contacts and/or vias to make the electrical connection of the diffusion regions of the cross-coupled transistors to the common node 495.Additionally, in various embodiments, conductive paths used to electrically connect the diffusion regions of the cross-coupled transistors to the common node 495 can be defined to traverse over essentially any area of the chip as required to accommodate a routing solution for the chip.", "Also, it should be appreciated that because the n-type and p-type diffusion regions are physically separate, and because the p-type diffusion regions for the two PMOS transistors of the cross-coupled transistors can be physically separate, and because the n-type diffusion regions for the two NMOS transistors of the cross-coupled transistors can be physically separate, it is possible in various embodiments to have each of the four cross-coupled transistors disposed at arbitrary locations in the layout relative to each other.", "Therefore, unless necessitated by electrical performance or other layout influencing conditions, it is not required that the four cross-coupled transistors be located within a prescribed proximity to each other in the layout.", "Although, location of the cross-coupled transistors within a prescribed proximity to each other is not precluded, and may be desirable in certain circuit layouts.", "In the exemplary embodiments disclosed herein, it should be understood that diffusion regions are not restricted in size.", "In other words, any given diffusion region can be sized in an arbitrary manner as required to satisfy electrical and/or layout requirements.", "Additionally, any given diffusion region can be shaped in an arbitrary manner as required to satisfy electrical and/or layout requirements.", "Also, it should be understood that the four transistors of the cross-coupled transistor configuration, as defined in accordance with the restricted gate level layout architecture, are not required to be the same size.", "In different embodiments, the four transistors of the cross-coupled transistor configuration can either vary in size (transistor width or transistor gate length) or have the same size, depending on the applicable electrical and/or layout requirements.", "Additionally, it should be understood that the four transistors of the cross-coupled transistor configuration are not required to be placed in close proximity to each, although they may be closely placed in some embodiments.", "More specifically, because connections between the transistors of the cross-coupled transistor configuration can be made by routing through as least one higher interconnect level, there is freedom in placement of the four transistors of the cross-coupled transistor configuration relative to each other.", "Although, it should be understood that a proximity of the four transistors of the cross-coupled transistor configuration may be governed in certain embodiments by electrical and/or layout optimization requirements.", "It should be appreciated that the cross-coupled transistor configurations and corresponding layouts implemented using the restricted gate level layout architecture, as described with regard to FIGS.", "2-13, and/or variants thereof, can be used to form many different electrical circuits.", "For example, a portion of a modern semiconductor chip is likely to include a number of multiplexer circuits and/or latch circuits.", "Such multiplexer and/or latch circuits can be defined using cross-coupled transistor configurations and corresponding layouts based on the restricted gate level layout architecture, as disclosed herein.", "Example multiplexer embodiments implemented using the restricted gate level layout architecture and corresponding cross-coupled transistor configurations are described with regard to FIGS.", "14A-17C.", "Example latch embodiments implemented using the restricted gate level layout architecture and corresponding cross-coupled transistor configurations are described with regard to FIGS.", "18A-22C.", "It should be understood that the multiplexer and latch embodiments described with regard to FIGS.", "14A-22C are provided by way of example and do not represent an exhaustive set of possible multiplexer and latch embodiments.", "Example Multiplexer Embodiments FIG.", "14A shows a generalized multiplexer circuit in which all four cross-coupled transistors 401, 405, 403, 407 are directly connected to the common node 495, in accordance with one embodiment of the present invention.", "As previously discussed, gates of the first PMOS transistor 401 and first NMOS transistor 407 are electrically connected, as shown by electrical connection 491.Also, gates of the second PMOS transistor 403 and second NMOS transistor 405 are electrically connected, as shown by electrical connection 493.Pull up logic 1401 is electrically connected to the first PMOS transistor 401 at a terminal opposite the common node 495.Pull down logic 1403 is electrically connected to the second NMOS transistor 405 at a terminal opposite the common node 495.Also, pull up logic 1405 is electrically connected to the second PMOS transistor 403 at a terminal opposite the common node 495.Pull down logic 1407 is electrically connected to the first NMOS transistor 407 at a terminal opposite the common node 495.FIG.", "14B shows an exemplary implementation of the multiplexer circuit of FIG.", "14A with a detailed view of the pull up logic 1401 and 1405, and the pull down logic 1403 and 1407, in accordance with one embodiment of the present invention.", "The pull up logic 1401 is defined by a PMOS transistor 1401A connected between a power supply (VDD) and a terminal 1411 of the first PMOS transistor 401 opposite the common node 495.The pull down logic 1403 is defined by an NMOS transistor 1403A connected between a ground potential (GND) and a terminal 1413 of the second NMOS transistor 405 opposite the common node 495.Respective gates of the PMOS transistor 1401A and NMOS transistor 1403A are connected together at a node 1415.The pull up logic 1405 is defined by a PMOS transistor 1405A connected between the power supply (VDD) and a terminal 1417 of the second PMOS transistor 403 opposite the common node 495.The pull down logic 1407 is defined by an NMOS transistor 1407A connected between a ground potential (GND) and a terminal 1419 of the first NMOS transistor 407 opposite the common node 495.Respective gates of the PMOS transistor 1405A and NMOS transistor 1407A are connected together at a node 1421.It should be understood that the implementations of pull up logic 1401, 1405 and pull down logic 1403, 1407 as shown in FIG.", "14B are exemplary.", "In other embodiments, logic different than that shown in FIG.", "14B can be used to implement the pull up logic 1401, 1405 and the pull down logic 1403, 1407.FIG.", "14C shows a multi-level layout of the multiplexer circuit of FIG.", "14B implemented using a restricted gate level layout architecture cross-coupled transistor layout, in accordance with one embodiment of the present invention.", "The electrical connection 491 between the gate electrode 401A of the first PMOS transistor 401 and the gate electrode 407A of the first NMOS transistor 407 is formed by a multi-level connection that includes a gate contact 1445, a (two-dimensional) metal-1 structure 1447, and a gate contact 1449.The electrical connection 493 between the gate electrode 403A of the second PMOS transistor 403 and the gate electrode 405A of the second NMOS transistor 405 is formed by a multi-level connection that includes a gate contact 1431, a (one-dimensional) metal-1 structure 1433, a via 1435, a (one-dimensional) metal-2 structure 1436, a via 1437, a (one-dimensional) metal-1 structure 1439, and a gate contact 1441.The common node electrical connection 495 is formed by a multi-level connection that includes a diffusion contact 1451, a (one-dimensional) metal-1 structure 1453, a via 1455, a (one-dimensional) metal-2 structure 1457, a via 1459, a (one-dimensional) metal-1 structure 1461, and a diffusion contact 1463.Respective gates of the PMOS transistor 1401A and NMOS transistor 1403A are connected to the node 1415 by a gate contact 1443.Also, respective gates of the PMOS transistor 1405A and NMOS transistor 1407A are connected to the node 1421 by a gate contact 1465.FIG.", "15A shows the multiplexer circuit of FIG.", "14A in which the two cross-coupled transistors 401 and 405 remain directly connected to the common node 495, and in which the two cross-coupled transistors 403 and 407 are positioned outside the pull up logic 1405 and pull down logic 1407, respectively, relative to the common node 495, in accordance with one embodiment of the present invention.", "Pull up logic 1405 is electrically connected between the second PMOS transistor 403 and the common node 495.Pull down logic 1407 is electrically connected between the first NMOS transistor 407 and the common node 495.With the exception of repositioning the PMOS/NMOS transistors 403/407 outside of their pull up/down logic 1405/1407 relative to the common node 495, the circuit of FIG.", "15A is the same as the circuit of FIG.", "14A.", "FIG.", "15B shows an exemplary implementation of the multiplexer circuit of FIG.", "15A with a detailed view of the pull up logic 1401 and 1405, and the pull down logic 1403 and 1407, in accordance with one embodiment of the present invention.", "As previously discussed with regard to FIG.", "14B, the pull up logic 1401 is defined by the PMOS transistor 1401A connected between VDD and the terminal 1411 of the first PMOS transistor 401 opposite the common node 495.Also, the pull down logic 1403 is defined by NMOS transistor 1403A connected between GND and the terminal 1413 of the second NMOS transistor 405 opposite the common node 495.Respective gates of the PMOS transistor 1401A and NMOS transistor 1403A are connected together at the node 1415.The pull up logic 1405 is defined by the PMOS transistor 1405A connected between the second PMOS transistor 403 and the common node 495.The pull down logic 1407 is defined by the NMOS transistor 1407A connected between the first NMOS transistor 407 and the common node 495.Respective gates of the PMOS transistor 1405A and NMOS transistor 1407A are connected together at the node 1421.It should be understood that the implementations of pull up logic 1401, 1405 and pull down logic 1403, 1407 as shown in FIG.", "15B are exemplary.", "In other embodiments, logic different than that shown in FIG.", "15B can be used to implement the pull up logic 1401, 1405 and the pull down logic 1403, 1407.FIG.", "15C shows a multi-level layout of the multiplexer circuit of FIG.", "15B implemented using a restricted gate level layout architecture cross-coupled transistor layout, in accordance with one embodiment of the present invention.", "The electrical connection 491 between the gate electrode 401A of the first PMOS transistor 401 and the gate electrode 407A of the first NMOS transistor 407 is formed by a multi-level connection that includes a gate contact 1501, a (one-dimensional) metal-1 structure 1503, a via 1505, a (one-dimensional) metal-2 structure 1507, a via 1509, a (one-dimensional) metal-1 structure 1511, and a gate contact 1513.The electrical connection 493 between the gate electrode 403A of the second PMOS transistor 403 and the gate electrode 405A of the second NMOS transistor 405 is formed by a multi-level connection that includes a gate contact 1515, a (two-dimensional) metal-1 structure 1517, and a gate contact 1519.The common node electrical connection 495 is formed by a multi-level connection that includes a diffusion contact 1521, a (one-dimensional) metal-1 structure 1523, a via 1525, a (one-dimensional) metal-2 structure 1527, a via 1529, a (one-dimensional) metal-1 structure 1531, and a diffusion contact 1533.Respective gates of the PMOS transistor 1401A and NMOS transistor 1403A are connected to the node 1415 by a gate contact 1535.Also, respective gates of the PMOS transistor 1405A and NMOS transistor 1407A are connected to the node 1421 by a gate contact 1539.FIG.", "16A shows a generalized multiplexer circuit in which the cross-coupled transistors (401, 403, 405, 407) are connected to form two transmission gates 1602, 1604 to the common node 495, in accordance with one embodiment of the present invention.", "As previously discussed, gates of the first PMOS transistor 401 and first NMOS transistor 407 are electrically connected, as shown by electrical connection 491.Also, gates of the second PMOS transistor 403 and second NMOS transistor 405 are electrically connected, as shown by electrical connection 493.The first PMOS transistor 401 and second NMOS transistor 405 are connected to form a first transmission gate 1602 to the common node 495.The second PMOS transistor 403 and first NMOS transistor 407 are connected to form a second transmission gate 1604 to the common node 495.Driving logic 1601 is electrically connected to both the first PMOS transistor 401 and second NMOS transistor 405 at a terminal opposite the common node 495.Driving logic 1603 is electrically connected to both the second PMOS transistor 403 and first NMOS transistor 407 at a terminal opposite the common node 495.FIG.", "16B shows an exemplary implementation of the multiplexer circuit of FIG.", "16A with a detailed view of the driving logic 1601 and 1603, in accordance with one embodiment of the present invention.", "In the embodiment of FIG.", "16B, the driving logic 1601 is defined by an inverter 1601A and, the driving logic 1603 is defined by an inverter 1603A.", "However, it should be understood that in other embodiments, the driving logic 1601 and 1603 can be defined by any logic function, such as a two input NOR gate, a two input NAND gate, AND-OR logic, OR-AND logic, among others, by way of example.", "FIG.", "16C shows a multi-level layout of the multiplexer circuit of FIG.", "16B implemented using a restricted gate level layout architecture cross-coupled transistor layout, in accordance with one embodiment of the present invention.", "The electrical connection 491 between the gate electrode 401A of the first PMOS transistor 401 and the gate electrode 407A of the first NMOS transistor 407 is formed by a multi-level connection that includes a gate contact 1619, a (two-dimensional) metal-1 structure 1621, and a gate contact 1623.The electrical connection 493 between the gate electrode 403A of the second PMOS transistor 403 and the gate electrode 405A of the second NMOS transistor 405 is formed by a multi-level connection that includes a gate contact 1605, a (one-dimensional) metal-1 structure 1607, a via 1609, a (one-dimensional) metal-2 structure 1611, a via 1613, a (one-dimensional) metal-1 structure 1615, and a gate contact 1617.The common node electrical connection 495 is formed by a multi-level connection that includes a diffusion contact 1625, a (one-dimensional) metal-1 structure 1627, a via 1629, a (one-dimensional) metal-2 structure 1631, a via 1633, a (one-dimensional) metal-1 structure 1635, and a diffusion contact 1637.Transistors which form the inverter 1601A are shown within the region bounded by the dashed line 1601AL.", "Transistors which form the inverter 1603A are shown within the region bounded by the dashed line 1603AL.", "FIG.", "17A shows a generalized multiplexer circuit in which two transistors (403, 407) of the four cross-coupled transistors are connected to form a transmission gate 1702 to the common node 495, in accordance with one embodiment of the present invention.", "As previously discussed, gates of the first PMOS transistor 401 and first NMOS transistor 407 are electrically connected, as shown by electrical connection 491.Also, gates of the second PMOS transistor 403 and second NMOS transistor 405 are electrically connected, as shown by electrical connection 493.The second PMOS transistor 403 and first NMOS transistor 407 are connected to form the transmission gate 1702 to the common node 495.Driving logic 1701 is electrically connected to both the second PMOS transistor 403 and first NMOS transistor 407 at a terminal opposite the common node 495.Pull up driving logic 1703 is electrically connected to the first PMOS transistor 401 at a terminal opposite the common node 495.Also, pull down driving logic 1705 is electrically connected to the second NMOS transistor 405 at a terminal opposite the common node 495.FIG.", "17B shows an exemplary implementation of the multiplexer circuit of FIG.", "17A with a detailed view of the driving logic 1701, 1703, and 1705, in accordance with one embodiment of the present invention.", "The driving logic 1701 is defined by an inverter 1701A.", "The pull up driving logic 1703 is defined by a PMOS transistor 1703A connected between VDD and the first PMOS transistor 401.The pull down driving logic 1705 is defined by an NMOS transistor 1705A connected between GND and the second NMOS transistor 405.Respective gates of the PMOS transistor 1703A and NMOS transistor 1705A are connected together at the node 1707.It should be understood that the implementations of driving logic 1701, 1703, and 1705, as shown in FIG.", "17B are exemplary.", "In other embodiments, logic different than that shown in FIG.", "17B can be used to implement the driving logic 1701, 1703, and 1705.FIG.", "17C shows a multi-level layout of the multiplexer circuit of FIG.", "17B implemented using a restricted gate level layout architecture cross-coupled transistor layout, in accordance with one embodiment of the present invention.", "The electrical connection 491 between the gate electrode 401A of the first PMOS transistor 401 and the gate electrode 407A of the first NMOS transistor 407 is formed by a multi-level connection that includes a gate contact 1723, a (two-dimensional) metal-1 structure 1725, and a gate contact 1727.The electrical connection 493 between the gate electrode 403A of the second PMOS transistor 403 and the gate electrode 405A of the second NMOS transistor 405 is formed by a multi-level connection that includes a gate contact 1709, a (one-dimensional) metal-1 structure 1711, a via 1713, a (one-dimensional) metal-2 structure 1715, a via 1717, a (one-dimensional) metal-1 structure 1719, and a gate contact 1721.The common node electrical connection 495 is formed by a multi-level connection that includes a diffusion contact 1729, a (one-dimensional) metal-1 structure 1731, a via 1733, a (one-dimensional) metal-2 structure 1735, a via 1737, a (one-dimensional) metal-1 structure 1739, and a diffusion contact 1741.Transistors which form the inverter 1701A are shown within the region bounded by the dashed line 1701AL.", "Respective gates of the PMOS transistor 1703A and NMOS transistor 1705A are connected to the node 1707 by a gate contact 1743.Example Latch Embodiments FIG.", "18A shows a generalized latch circuit implemented using the cross-coupled transistor configuration, in accordance with one embodiment of the present invention.", "The gates of the first PMOS transistor 401 and first NMOS transistor 407 are electrically connected, as shown by electrical connection 491.The gates of the second PMOS transistor 403 and second NMOS transistor 405 are electrically connected, as shown by electrical connection 493.Each of the four cross-coupled transistors are electrically connected to the common node 495.It should be understood that the common node 495 serves as a storage node in the latch circuit.", "Pull up driver logic 1805 is electrically connected to the second PMOS transistor 403 at a terminal opposite the common node 495.Pull down driver logic 1807 is electrically connected to the first NMOS transistor 407 at a terminal opposite the common node 495.Pull up feedback logic 1809 is electrically connected to the first PMOS transistor 401 at a terminal opposite the common node 495.Pull down feedback logic 1811 is electrically connected to the second NMOS transistor 405 at a terminal opposite the common node 495.Additionally, the common node 495 is connected to an input of an inverter 1801.An output of the inverter 1801 is electrically connected to a feedback node 1803.It should be understood that in other embodiments the inverter 1801 can be replaced by any logic function, such as a two input NOR gate, a two input NAND gate, among others, or any complex logic function.", "FIG.", "18B shows an exemplary implementation of the latch circuit of FIG.", "18A with a detailed view of the pull up driver logic 1805, the pull down driver logic 1807, the pull up feedback logic 1809, and the pull down feedback logic 1811, in accordance with one embodiment of the present invention.", "The pull up driver logic 1805 is defined by a PMOS transistor 1805A connected between VDD and the second PMOS transistor 403 opposite the common node 495.The pull down driver logic 1807 is defined by an NMOS transistor 1807A connected between GND and the first NMOS transistor 407 opposite the common node 495.Respective gates of the PMOS transistor 1805A and NMOS transistor 1807A are connected together at a node 1804.The pull up feedback logic 1809 is defined by a PMOS transistor 1809A connected between VDD and the first PMOS transistor 401 opposite the common node 495.The pull down feedback logic 1811 is defined by an NMOS transistor 1811A connected between GND and the second NMOS transistor 405 opposite the common node 495.Respective gates of the PMOS transistor 1809A and NMOS transistor 1811A are connected together at the feedback node 1803.It should be understood that the implementations of pull up driver logic 1805, pull down driver logic 1807, pull up feedback logic 1809, and pull down feedback logic 1811 as shown in FIG.", "18B are exemplary.", "In other embodiments, logic different than that shown in FIG.", "18B can be used to implement the pull up driver logic 1805, the pull down driver logic 1807, the pull up feedback logic 1809, and the pull down feedback logic 1811.FIG.", "18C shows a multi-level layout of the latch circuit of FIG.", "18B implemented using a restricted gate level layout architecture cross-coupled transistor layout, in accordance with one embodiment of the present invention.", "The electrical connection 491 between the gate electrode 401A of the first PMOS transistor 401 and the gate electrode 407A of the first NMOS transistor 407 is formed by a multi-level connection that includes a gate contact 1813, a (one-dimensional) metal-1 structure 1815, a via 1817, a (one-dimensional) metal-2 structure 1819, a via 1821, a (one-dimensional) metal-1 structure 1823, and a gate contact 1825.The electrical connection 493 between the gate electrode 403A of the second PMOS transistor 403 and the gate electrode 405A of the second NMOS transistor 405 is formed by a multi-level connection that includes a gate contact 1827, a (two-dimensional) metal-1 structure 1829, and a gate contact 1831.The common node electrical connection 495 is formed by a multi-level connection that includes a diffusion contact 1833, a (one-dimensional) metal-1 structure 1835, a via 1837, a (one-dimensional) metal-2 structure 1839, a via 1841, a (two-dimensional) metal-1 structure 1843, and a diffusion contact 1845.Transistors which form the inverter 1801 are shown within the region bounded by the dashed line 1801L.", "FIG.", "19A shows the latch circuit of FIG.", "18A in which the two cross-coupled transistors 401 and 405 remain directly connected to the output node 495, and in which the two cross-coupled transistors 403 and 407 are positioned outside the pull up driver logic 1805 and pull down driver logic 1807, respectively, relative to the common node 495, in accordance with one embodiment of the present invention.", "Pull up driver logic 1805 is electrically connected between the second PMOS transistor 403 and the common node 495.Pull down driver logic 1807 is electrically connected between the first NMOS transistor 407 and the common node 495.With the exception of repositioning the PMOS/NMOS transistors 403/407 outside of their pull up/down driver logic 1805/1807 relative to the common node 495, the circuit of FIG.", "19A is the same as the circuit of FIG.", "18A.", "FIG.", "19B shows an exemplary implementation of the latch circuit of FIG.", "19A with a detailed view of the pull up driver logic 1805, pull down driver logic 1807, pull up feedback logic 1809, and pull down feedback logic 1811, in accordance with one embodiment of the present invention.", "As previously discussed with regard to FIG.", "18B, the pull up feedback logic 1809 is defined by the PMOS transistor 1809A connected between VDD and the first PMOS transistor 401 opposite the common node 495.Also, the pull down feedback logic 1811 is defined by NMOS transistor 1811A connected between GND and the second NMOS transistor 405 opposite the common node 495.Respective gates of the PMOS transistor 1809A and NMOS transistor 1811A are connected together at the feedback node 1803.The pull up driver logic 1805 is defined by the PMOS transistor 1805A connected between the second PMOS transistor 403 and the common node 495.The pull down driver logic 1807 is defined by the NMOS transistor 1807A connected between the first NMOS transistor 407 and the common node 495.Respective gates of the PMOS transistor 1805A and NMOS transistor 1807A are connected together at the node 1804.It should be understood that the implementations of pull up driver logic 1805, pull down driver logic 1807, pull up feedback logic 1809, and pull down feedback logic 1811 as shown in FIG.", "19B are exemplary.", "In other embodiments, logic different than that shown in FIG.", "19B can be used to implement the pull up driver logic 1805, the pull down driver logic 1807, the pull up feedback logic 1809, and the pull down feedback logic 1811.FIG.", "19C shows a multi-level layout of the latch circuit of FIG.", "19B implemented using a restricted gate level layout architecture cross-coupled transistor layout, in accordance with one embodiment of the present invention.", "The electrical connection 491 between the gate electrode 401A of the first PMOS transistor 401 and the gate electrode 407A of the first NMOS transistor 407 is formed by a multi-level connection that includes a gate contact 1901, a (one-dimensional) metal-1 structure 1903, a via 1905, a (one-dimensional) metal-2 structure 1907, a via 1909, a (one-dimensional) metal-1 structure 1911, and a gate contact 1913.The electrical connection 493 between the gate electrode 403A of the second PMOS transistor 403 and the gate electrode 405A of the second NMOS transistor 405 is formed by a multi-level connection that includes a gate contact 1915, a (two-dimensional) metal-1 structure 1917, and a gate contact 1919.The common node electrical connection 495 is formed by a multi-level connection that includes a diffusion contact 1921, a (one-dimensional) metal-1 structure 1923, a via 1925, a (one-dimensional) metal-2 structure 1927, a via 1929, a (two-dimensional) metal-1 structure 1931, and a diffusion contact 1933.Transistors which form the inverter 1801 are shown within the region bounded by the dashed line 1801L.", "FIG.", "20A shows the latch circuit of FIG.", "18A in which the two cross-coupled transistors 403 and 407 remain directly connected to the output node 495, and in which the two cross-coupled transistors 401 and 405 are positioned outside the pull up feedback logic 1809 and pull down feedback logic 1811, respectively, relative to the common node 495, in accordance with one embodiment of the present invention.", "Pull up feedback logic 1809 is electrically connected between the first PMOS transistor 401 and the common node 495.Pull down feedback logic 1811 is electrically connected between the second NMOS transistor 405 and the common node 495.With the exception of repositioning the PMOS/NMOS transistors 401/405 outside of their pull up/down feedback logic 1809/1811 relative to the common node 495, the circuit of FIG.", "20A is the same as the circuit of FIG.", "18A.", "FIG.", "20B shows an exemplary implementation of the latch circuit of FIG.", "20A with a detailed view of the pull up driver logic 1805, pull down driver logic 1807, pull up feedback logic 1809, and pull down feedback logic 1811, in accordance with one embodiment of the present invention.", "The pull up feedback logic 1809 is defined by the PMOS transistor 1809A connected between the first PMOS transistor 401 and the common node 495.Also, the pull down feedback logic 1811 is defined by NMOS transistor 1811A connected between the second NMOS transistor 405 and the common node 495.Respective gates of the PMOS transistor 1809A and NMOS transistor 1811A are connected together at the feedback node 1803.The pull up driver logic 1805 is defined by the PMOS transistor 1805A connected between VDD and the second PMOS transistor 403.The pull down driver logic 1807 is defined by the NMOS transistor 1807A connected between GND and the first NMOS transistor 407.Respective gates of the PMOS transistor 1805A and NMOS transistor 1807A are connected together at the node 1804.It should be understood that the implementations of pull up driver logic 1805, pull down driver logic 1807, pull up feedback logic 1809, and pull down feedback logic 1811 as shown in FIG.", "20B are exemplary.", "In other embodiments, logic different than that shown in FIG.", "20B can be used to implement the pull up driver logic 1805, the pull down driver logic 1807, the pull up feedback logic 1809, and the pull down feedback logic 1811.FIG.", "20C shows a multi-level layout of the latch circuit of FIG.", "20B implemented using a restricted gate level layout architecture cross-coupled transistor layout, in accordance with one embodiment of the present invention.", "The electrical connection 491 between the gate electrode 401A of the first PMOS transistor 401 and the gate electrode 407A of the first NMOS transistor 407 is formed by a multi-level connection that includes a gate contact 2001, a (one-dimensional) metal-1 structure 2003, a via 2005, a (one-dimensional) metal-2 structure 2007, a via 2009, a (one-dimensional) metal-1 structure 2011, and a gate contact 2013.The electrical connection 493 between the gate electrode 403A of the second PMOS transistor 403 and the gate electrode 405A of the second NMOS transistor 405 is formed by a multi-level connection that includes a gate contact 2015, a (one-dimensional) metal-1 structure 2017, and a gate contact 2019.The common node electrical connection 495 is formed by a multi-level connection that includes a diffusion contact 2021, a (two-dimensional) metal-1 structure 2023, and a diffusion contact 2025.Transistors which form the inverter 1801 are shown within the region bounded by the dashed line 1801L.", "FIG.", "21A shows a generalized latch circuit in which the cross-coupled transistors (401, 403, 405, 407) are connected to form two transmission gates 2103, 2105 to the common node 495, in accordance with one embodiment of the present invention.", "As previously discussed, gates of the first PMOS transistor 401 and first NMOS transistor 407 are electrically connected, as shown by electrical connection 491.Also, gates of the second PMOS transistor 403 and second NMOS transistor 405 are electrically connected, as shown by electrical connection 493.The first PMOS transistor 401 and second NMOS transistor 405 are connected to form a first transmission gate 2103 to the common node 495.The second PMOS transistor 403 and first NMOS transistor 407 are connected to form a second transmission gate 2105 to the common node 495.Feedback logic 2109 is electrically connected to both the first PMOS transistor 401 and second NMOS transistor 405 at a terminal opposite the common node 495.Driving logic 2107 is electrically connected to both the second PMOS transistor 403 and first NMOS transistor 407 at a terminal opposite the common node 495.Additionally, the common node 495 is connected to the input of the inverter 1801.The output of the inverter 1801 is electrically connected to a feedback node 2101.It should be understood that in other embodiments the inverter 1801 can be replaced by any logic function, such as a two input NOR gate, a two input NAND gate, among others, or any complex logic function.", "FIG.", "21B shows an exemplary implementation of the latch circuit of FIG.", "21A with a detailed view of the driving logic 2107 and feedback logic 2109, in accordance with one embodiment of the present invention.", "The driving logic 2107 is defined by an inverter 2107A.", "Similarly, the feedback logic 2109 is defined by an inverter 2109A.", "It should be understood that in other embodiments, the driving logic 2107 and/or 2109 can be defined by logic other than an inverter.", "FIG.", "21C shows a multi-level layout of the latch circuit of FIG.", "21B implemented using a restricted gate level layout architecture cross-coupled transistor layout, in accordance with one embodiment of the present invention.", "The electrical connection 491 between the gate electrode 401A of the first PMOS transistor 401 and the gate electrode 407A of the first NMOS transistor 407 is formed by a multi-level connection that includes a gate contact 2111, a (one-dimensional) metal-1 structure 2113, a via 2115, a (one-dimensional) metal-2 structure 2117, a via 2119, a (one-dimensional) metal-1 structure 2121, and a gate contact 2123.The electrical connection 493 between the gate electrode 403A of the second PMOS transistor 403 and the gate electrode 405A of the second NMOS transistor 405 is formed by a multi-level connection that includes a gate contact 2125, a (two-dimensional) metal-1 structure 2127, and a gate contact 2129.The common node electrical connection 495 is formed by a multi-level connection that includes a diffusion contact 2131, a (one-dimensional) metal-1 structure 2133, a via 2135, a (one-dimensional) metal-2 structure 2137, a via 2139, a (two-dimensional) metal-1 structure 2141, and a diffusion contact 2143.Transistors which form the inverter 2107A are shown within the region bounded by the dashed line 2107AL.", "Transistors which form the inverter 2109A are shown within the region bounded by the dashed line 2109AL.", "Transistors which form the inverter 1801 are shown within the region bounded by the dashed line 1801L.", "FIG.", "22A shows a generalized latch circuit in which two transistors (403, 407) of the four cross-coupled transistors are connected to form a transmission gate 2105 to the common node 495, in accordance with one embodiment of the present invention.", "As previously discussed, gates of the first PMOS transistor 401 and first NMOS transistor 407 are electrically connected, as shown by electrical connection 491.Also, gates of the second PMOS transistor 403 and second NMOS transistor 405 are electrically connected, as shown by electrical connection 493.The second PMOS transistor 403 and first NMOS transistor 407 are connected to form the transmission gate 2105 to the common node 495.Driving logic 2201 is electrically connected to both the second PMOS transistor 403 and first NMOS transistor 407 at a terminal opposite the common node 495.Pull up feedback logic 2203 is electrically connected to the first PMOS transistor 401 at a terminal opposite the common node 495.Also, pull down feedback logic 2205 is electrically connected to the second NMOS transistor 405 at a terminal opposite the common node 495.FIG.", "22B shows an exemplary implementation of the latch circuit of FIG.", "22A with a detailed view of the driving logic 2201, the pull up feedback logic 2203, and the pull down feedback logic 2205, in accordance with one embodiment of the present invention.", "The driving logic 2201 is defined by an inverter 2201A.", "The pull up feedback logic 2203 is defined by a PMOS transistor 2203A connected between VDD and the first PMOS transistor 401.The pull down feedback logic 2205 is defined by an NMOS transistor 2205A connected between GND and the second NMOS transistor 405.Respective gates of the PMOS transistor 2203A and NMOS transistor 2205A are connected together at the feedback node 2101.It should be understood that in other embodiments, the driving logic 2201 can be defined by logic other than an inverter.", "Also, it should be understood that in other embodiments, the pull up feedback logic 2203 and/or pull down feedback logic 2205 can be defined logic different than what is shown in FIG.", "22B.", "FIG.", "22C shows a multi-level layout of the latch circuit of FIG.", "22B implemented using a restricted gate level layout architecture cross-coupled transistor layout, in accordance with one embodiment of the present invention.", "The electrical connection 491 between the gate electrode 401A of the first PMOS transistor 401 and the gate electrode 407A of the first NMOS transistor 407 is formed by a multi-level connection that includes a gate contact 2207, a (one-dimensional) metal-1 structure 2209, a via 2211, a (one-dimensional) metal-2 structure 2213, a via 2215, a (one-dimensional) metal-1 structure 2217, and a gate contact 2219.The electrical connection 493 between the gate electrode 403A of the second PMOS transistor 403 and the gate electrode 405A of the second NMOS transistor 405 is formed by a multi-level connection that includes a gate contact 2221, a (two-dimensional) metal-1 structure 2223, and a gate contact 2225.The common node electrical connection 495 is formed by a multi-level connection that includes a diffusion contact 2227, a (one-dimensional) metal-1 structure 2229, a via 2231, a (one-dimensional) metal-2 structure 2233, a via 2235, a (two-dimensional) metal-1 structure 2237, and a diffusion contact 2239.Transistors which form the inverter 2201A are shown within the region bounded by the dashed line 2201AL.", "Transistors which form the inverter 1801 are shown within the region bounded by the dashed line 1801L.", "Exemplary Embodiments In one embodiment, a cross-coupled transistor configuration is defined within a semiconductor chip.", "This embodiment is illustrated in part with regard to FIG.", "2.In this embodiment, a first P channel transistor (401) is defined to include a first gate electrode (401A) defined in a gate level of the chip.", "Also, a first N channel transistor (407) is defined to include a second gate electrode (407A) defined in the gate level of the chip.", "The second gate electrode (407A) of the first N channel transistor (407) is electrically connected to the first gate electrode (401A) of the first P channel transistor (401).", "Further, a second P channel transistor (403) is defined to include a third gate electrode (403A) defined in the gate level of a chip.", "Also, a second N channel transistor (405) is defined to include a fourth gate electrode (405A) defined in the gate level of the chip.", "The fourth gate electrode (405A) of the second N channel transistor (405) is electrically connected to the third gate electrode (403A) of the second P channel transistor (403).", "Additionally, each of the first P channel transistor (401), first N channel transistor (407), second P channel transistor (403), and second N channel transistor (405) has a respective diffusion terminal electrically connected to a common node (495).", "It should be understood that in some embodiments, one or more of the first P channel transistor (401), the first N channel transistor (407), the second P channel transistor (403), and the second N channel transistor (405) can be respectively implemented by a number of transistors electrically connected in parallel.", "In this instance, the transistors that are electrically connected in parallel can be considered as one device corresponding to either of the first P channel transistor (401), the first N channel transistor (407), the second P channel transistor (403), and the second N channel transistor (405).", "It should be understood that electrical connection of multiple transistors in parallel to form a given transistor of the cross-coupled transistor configuration can be utilized to achieve a desired drive strength for the given transistor.", "In one embodiment, each of the first (401A), second (407A), third (403A), and fourth (405A) gate electrodes is defined to extend along any of a number of gate electrode tracks, such as described with regard to FIG.", "3.The number of gate electrode tracks extend across the gate level of the chip in a parallel orientation with respect to each other.", "Also, it should be understood that each of the first (401A), second (407A), third (403A), and fourth (405A) gate electrodes corresponds to a portion of a respective gate level feature defined within a gate level feature layout channel.", "Each gate level feature is defined within its gate level feature layout channel without physically contacting another gate level feature defined within an adjoining gate level feature layout channel.", "Each gate level feature layout channel is associated with a given gate electrode track and corresponds to a layout region that extends along the given gate electrode track and perpendicularly outward in each opposing direction from the given gate electrode track to a closest of either an adjacent gate electrode track or a virtual gate electrode track outside a layout boundary, such as described with regard to FIG.", "3B.", "In various implementations of the above-described embodiment, such as in the exemplary layouts of FIGS.", "10, 11, 14C, 15C, 16C, 17C, 18C, 19C, 20C, 21C, 22C, the second gate electrode (407A) is electrically connected to the first gate electrode (401A) through at least one electrical conductor defined within any chip level other than the gate level.", "And, the fourth gate electrode (405A) is electrically connected to the third gate electrode (403A) through at least one electrical conductor defined within any chip level other than the gate level.", "In various implementations of the above-described embodiment, such as in the exemplary layout of FIG.", "13, both the second gate electrode (407A) and the first gate electrode (401A) are formed from a single gate level feature that is defined within a same gate level feature layout channel that extends along a single gate electrode track over both a p type diffusion region and an n type diffusion region.", "And, the fourth gate electrode (405A) is electrically connected to the third gate electrode (403A) through at least one electrical conductor defined within any chip level other than the gate level.", "In various implementations of the above-described embodiment, such as in the exemplary layouts of FIG.", "12, both the second gate electrode (407A) and the first gate electrode (401A) are formed from a first gate level feature that is defined within a first gate level feature layout channel that extends along a first gate electrode track over both a p type diffusion region and an n type diffusion region.", "And, both the fourth gate electrode (405A) and the third gate electrode (403A) are formed from a second gate level feature that is defined within a second gate level feature layout channel that extends along a second gate electrode track over both a p type diffusion region and an n type diffusion region.", "In one embodiment, the above-described gate electrode cross-coupled transistor configuration is used to implement a multiplexer having no transmission gates.", "This embodiment is illustrated in part with regard to FIGS.", "14-15.In this embodiment, a first configuration of pull-up logic (1401) is electrically connected to the first P channel transistor (401), a first configuration of pull-down logic (1407) electrically connected to the first N channel transistor (407), a second configuration of pull-up logic (1405) electrically connected to the second P channel transistor (403), and a second configuration of pull-down logic (1403) electrically connected to the second N channel transistor (405).", "In the particular embodiments of FIGS.", "14B and 15B, the first configuration of pull-up logic (1401) is defined by a third P channel transistor (1401A), and the second configuration of pull-down logic (1403) is defined by a third N channel transistor (1403A).", "Respective gates of the third P channel transistor (1401A) and third N channel transistor (1403A) are electrically connected together so as to receive a substantially equivalent electrical signal.", "Moreover, the first configuration of pull-down logic (1407) is defined by a fourth N channel transistor (1407A), and the second configuration of pull-up logic (1405) is defined by a fourth P channel transistor (1405A).", "Respective gates of the fourth P channel transistor (1405A) and fourth N channel transistor (1407A) are electrically connected together so as to receive a substantially equivalent electrical signal.", "In one embodiment, the above-described gate electrode cross-coupled transistor configuration is used to implement a multiplexer having one transmission gate.", "This embodiment is illustrated in part with regard to FIG.", "17.In this embodiment, a first configuration of pull-up logic (1703) is electrically connected to the first P channel transistor (401), a first configuration of pull-down logic (1705) electrically connected to the second N channel transistor (405), and mux driving logic (1701) is electrically connected to both the second P channel transistor (403) and the first N channel transistor (407).", "In the exemplary embodiment of FIG.", "17B, the first configuration of pull-up logic (1703) is defined by a third P channel transistor (1703A), and the first configuration of pull-down logic (1705) is defined by a third N channel transistor (1705A).", "Respective gates of the third P channel transistor (1703A) and third N channel transistor (1705A) are electrically connected together so as to receive a substantially equivalent electrical signal.", "Also, the mux driving logic (1701) is defined by an inverter (1701A).", "In one embodiment, the above-described gate electrode cross-coupled transistor configuration is used to implement a latch having no transmission gates.", "This embodiment is illustrated in part with regard to FIGS.", "18-20.In this embodiment, pull-up driver logic (1805) is electrically connected to the second P channel transistor (403), pull-down driver logic (1807) is electrically connected to the first N channel transistor (407), pull-up feedback logic (1809) is electrically connected to the first P channel transistor (401), and pull-down feedback logic (1811) is electrically connected to the second N channel transistor (405).", "Also, the latch includes an inverter (1801) having an input connected to the common node (495) and an output connected to a feedback node (1803).", "Each of the pull-up feedback logic (1809) and pull-down feedback logic (1811) is connected to the feedback node (1803).", "In the exemplary embodiments of FIGS.", "18B, 19B, and 20B, the pull-up driver logic (1805) is defined by a third P channel transistor (1805A), and the pull-down driver logic (1807) is defined by a third N channel transistor (1807A).", "Respective gates of the third P channel transistor (1805A) and third N channel transistor (1807A) are electrically connected together so as to receive a substantially equivalent electrical signal.", "Additionally, the pull-up feedback logic (1809) is defined by a fourth P channel transistor (1809A), and the pull-down feedback logic (1811) is defined by a fourth N channel transistor (1811A).", "Respective gates of the fourth P channel transistor (1809A) and fourth N channel transistor (1811A) are electrically connected together at the feedback node (1803).", "In one embodiment, the above-described gate electrode cross-coupled transistor configuration is used to implement a latch having two transmission gates.", "This embodiment is illustrated in part with regard to FIG.", "21.In this embodiment, driving logic (2107) is electrically connected to both the second P channel transistor (403) and the first N channel transistor (407).", "Also, feedback logic (2109) is electrically connected to both the first P channel transistor (401) and the second N channel transistor (405).", "The latch further includes a first inverter (1801) having an input connected to the common node (495) and an output connected to a feedback node (2101).", "The feedback logic (2109) is electrically connected to the feedback node (2101).", "In the exemplary embodiment of FIG.", "21B, the driving logic (2107) is defined by a second inverter (2107A), and the feedback logic (2109) is defined by a third inverter (2109A).", "In one embodiment, the above-described gate electrode cross-coupled transistor configuration is used to implement a latch having one transmission gate.", "This embodiment is illustrated in part with regard to FIG.", "22.In this embodiment, driving logic (2201) is electrically connected to both the second P channel transistor (403) and the first N channel transistor (407).", "Also, pull up feedback logic (2203) is electrically connected to the first P channel transistor (401), and pull down feedback logic (2205) electrically connected to the second N channel transistor (405).", "The latch further includes a first inverter (1801) having an input connected to the common node (495) and an output connected to a feedback node (2101).", "Both the pull up feedback logic (2203) and pull down feedback logic (2205) are electrically connected to the feedback node (2101).", "In the exemplary embodiment of FIG.", "22B, the driving logic (2201) is defined by a second inverter (2201A).", "Also, the pull up feedback logic (2203) is defined by a third P channel transistor (2203A) electrically connected between the first P channel transistor (401) and the feedback node (2101).", "The pull down feedback logic (2205) is defined by a third N channel transistor (2205A) electrically connected between the second N channel transistor (405) and the feedback node (2101).", "In one embodiment, cross-coupled transistors devices are defined and connected to form part of an integrated circuit within a semiconductor chip (“chip” hereafter).", "The chip includes a number of levels within which different features are defined to form the integrated circuit and cross-coupled transistors therein.", "The chip includes a substrate within which a number of diffusion regions are formed.", "The chip also includes a gate level in which a number of gate electrodes are formed.", "The chip further includes a number of interconnect levels successively defined above the gate level.", "A dielectric material is used to electrically separate a given level from its vertically adjacent levels.", "A number of contact features are defined to extend vertically through the chip to connect gate electrode features and diffusion regions, respectively, to various interconnect level features.", "Also, a number of via features are defined to extend vertically through the chip to connect various interconnect level features.", "The gate level of the various embodiments disclosed herein is defined as a linear gate level and includes a number of commonly oriented linear gate level features.", "Some of the linear gate level features form gate electrodes of transistor devices.", "Others of the linear gate level features can form conductive segments extending between two points within the gate level.", "Also, others of the linear gate level features may be non-functional with respect to integrated circuit operation.", "It should be understood that the each of the linear gate level features, regardless of function, is defined to extend across the gate level in a common direction and to be devoid of a substantial change in direction along its length.", "Therefore, each of the gate level features is defined to be parallel to each other when viewed from a perspective perpendicular to the gate level.", "It should be understood that each of the linear gate electrode features, regardless of function, is defined such that no linear gate electrode feature along a given line of extent is configured to connect directly within the gate electrode level to another linear gate electrode feature defined along another parallel line of extent, without utilizing a non-gate electrode feature.", "Moreover, each connection between linear gate electrode features that are placed on different, yet parallel, lines of extent is made through one or more non-gate electrode features, which may be defined in higher interconnect level(s), i.e., through one or more interconnect level(s) above the gate electrode level, or by way of local interconnect features within the linear gate level.", "In one embodiment, the linear gate electrode features are placed according to a virtual grid or virtual grate.", "However, it should be understood that in other embodiments the linear gate electrode features, although oriented to have a common direction of extent, are placed without regard to a virtual grid or virtual grate.", "Additionally, it should be understood that while each linear gate electrode feature is defined to be devoid of a substantial change in direction along its line of extent, each linear gate electrode feature may have one or more contact head portion(s) defined at any number of location(s) along its length.", "A contact head portion of a given linear gate electrode feature is defined as a segment of the linear gate electrode feature having a different width than a gate portion of the linear gate electrode feature, i.e., than a portion of the linear gate electrode feature that extends over a diffusion region, wherein “width” is defined across the substrate in a direction perpendicular to the line of extent of the given linear gate electrode feature.", "It should be appreciated that a contact head of linear gate electrode feature, when viewed from above, can be defined by essentially any rectangular layout shape, including a square and a rectangle.", "Also, depending on layout requirements and circuit design, a given contact head portion of a linear gate electrode feature may or may not have a gate contact defined thereabove.", "In one embodiment, a substantial change in direction of a linear gate level feature exists when the width of the linear gate level feature at any point thereon changes by more than 50% of the nominal width of the linear gate level feature along its entire length.", "In another embodiment, a substantial change in direction of a linear gate level feature exists when the width of the linear gate level feature changes from any first location on the linear gate level feature to any second location on the linear gate level feature by more that 50% of the linear gate level feature width at the first location.", "Therefore, it should be appreciated that the use of non-linear-shaped gate level features is specifically avoided, wherein a non-linear-shaped gate level feature includes one or more significant bends within a plane of the gate level.", "Each of the linear gate level features has a width defined perpendicular to its direction of extent across the gate level.", "In one embodiment, the various gate level features can be defined to have different widths.", "In another embodiment, the various gate level features can be defined to have the same width.", "Also, a center-to-center spacing between adjacent linear gate level features, as measured perpendicular to their direction of extent across the gate level, is referred to as gate pitch.", "In one embodiment, a uniform gate pitch is used.", "However, in another embodiment, the gate pitch can vary across the gate level.", "It should be understood that linear gate level feature width and pitch specifications can be established for a portion of the chip and can be different for separate portions of the chip, wherein the portion of the chip may be of any size and shape.", "Various embodiments are disclosed herein for cross-coupled transistor layouts defined using the linear gate level as described above.", "Each cross-coupled transistor layout embodiment includes four cross-coupled transistors, wherein each of these four cross-coupled transistors is defined in part by a respective linear gate electrode feature, and wherein the linear gate electrode features of the cross-coupled transistors are oriented to extend across the layout in a parallel relationship to each other.", "Also, in each cross-coupled transistor layout, each of the gate electrodes of the four cross-coupled transistors is associated with, i.e., electrically interfaced with, a respective diffusion region.", "The diffusion regions associated with the gate electrodes of the cross-coupled transistors are electrically connected to a common node.", "In various embodiments, connection of the cross-coupled transistor's diffusion regions to the common node can be made in many different ways.", "For example, in one embodiment, two PMOS transistors of the cross-coupled transistors are disposed over a common p-type diffusion region, two NMOS transistors of the cross-coupled transistors are disposed over a common n-type diffusion region, and the p-type and n-type diffusion regions associated with the cross-coupled transistors are electrically connected to a common node.", "FIGS.", "26-99, 150-157, and 168-172 illustrate various cross-coupled transistor layout embodiments in which two PMOS transistors of the cross-coupled transistors are disposed over a common p-type diffusion region, two NMOS transistors of the cross-coupled transistors are disposed over a common n-type diffusion region, and the p-type and n-type diffusion regions associated with the cross-coupled transistors are electrically connected to a common node.", "It should be understood that although FIGS.", "26-99 do not explicitly show an electrical connection of the n-type and p-type diffusion regions of the cross-coupled transistors to a common node, this common node connection between the n-type and p-type diffusion regions of the cross-coupled transistors is present in a full version of the exemplary layouts.", "In another embodiment, two PMOS transistors of the cross-coupled transistors are respectively disposed over physically separated p-type diffusion regions, two NMOS transistors of the cross-coupled transistors are disposed over a common n-type diffusion region, and the p-type and n-type diffusion regions associated with the cross-coupled transistors are electrically connected to a common node.", "FIGS.", "103, 105, 112-149, 167, 184, and 186 illustrate various cross-coupled transistor layout embodiments in which two PMOS transistors of the cross-coupled transistors are respectively disposed over physically separated p-type diffusion regions, two NMOS transistors of the cross-coupled transistors are disposed over a common n-type diffusion region, and the p-type and n-type diffusion regions associated with the cross-coupled transistors are electrically connected to a common node.", "In another embodiment, two PMOS transistors of the cross-coupled transistors are disposed over a common p-type diffusion region, two NMOS transistors of the cross-coupled transistors are respectively disposed over physically separated n-type diffusion regions, and the p-type and n-type diffusion regions associated with the cross-coupled transistors are electrically connected to a common node.", "FIG.", "100 as shown and each of FIGS.", "103, 105, 112-149, 167, 184, and 186 with the p-type and n-type diffusion regions reversed to n-type and p-type, respectively, illustrate various cross-coupled transistor layout embodiments in which two PMOS transistors of the cross-coupled transistors are disposed over a common p-type diffusion region, two NMOS transistors of the cross-coupled transistors are respectively disposed over physically separated n-type diffusion regions, and the p-type and n-type diffusion regions associated with the cross-coupled transistors are electrically connected to a common node.", "In yet another embodiment, two PMOS transistors of the cross-coupled transistors are respectively disposed over physically separated p-type diffusion regions, two NMOS transistors of the cross-coupled transistors are respectively disposed over physically separated n-type diffusion regions, and the p-type and n-type diffusion regions associated with the cross-coupled transistors are electrically connected to a common node.", "FIGS.", "158-166, 173-183, 185, and 187-191 illustrate various cross-coupled transistor layout embodiments in which two PMOS transistors of the cross-coupled transistors are respectively disposed over physically separated p-type diffusion regions, two NMOS transistors of the cross-coupled transistors are respectively disposed over physically separated n-type diffusion regions, and the p-type and n-type diffusion regions associated with the cross-coupled transistors are electrically connected to a common node.", "It should be understood that the electrical connection of the various p-type and n-type diffusion regions associated with the cross-coupled transistors to the common node can be made using electrical conductors defined within any level of the chip and within any number of levels of the chip, by way of contact and/or vias, so as to accommodate essentially any cross-coupled layout configuration defined in accordance with the linear gate level restrictions.", "In one embodiment, electrical connection of the diffusion regions of the cross-coupled transistors to the common node can be made using one or more local interconnect conductors defined within the gate level itself.", "This embodiment may also combine local interconnect conductors with conductors in higher levels (above the linear gate level) by way of contacts and/or vias to make the electrical connection of the diffusion regions of the cross-coupled transistors to the common node.", "Additionally, in various embodiments, conductive paths used to electrically connect the diffusion regions of the cross-coupled transistors to the common node can be defined to traverse over essentially any area of the chip as required to accommodate a routing solution for the chip.", "Also, it should be appreciated that because the n-type and p-type diffusion regions are physically separate, and because the p-type diffusion regions for the two PMOS transistors of the cross-coupled transistors can be physically separate, and because the n-type diffusion regions for the two NMOS transistors of the cross-coupled transistors can be physically separate, it is possible in various embodiments to have each of the four cross-coupled transistors disposed at arbitrary locations in the layout relative to each other.", "Therefore, unless necessitated by electrical performance or other layout influencing conditions, it is not required that the four cross-coupled transistors be located within a prescribed proximity to each other in the layout.", "Although, location of the cross-coupled transistors within a prescribed proximity to each other is not precluded, and may be desirable in certain circuit layouts.", "FIG.", "26 is an illustration showing an exemplary cross-coupled transistor layout, in accordance with one embodiment of the present invention.", "The cross-couple layout includes four transistors 102p, 104p, 106p, 108p.", "Transistors 102p, 106p are defined over a first diffusion region 110p.", "Transistors 108p, 104p are defined over a second diffusion region 112p.", "In one embodiment, the first diffusion region 110p is defined such that transistors 102p and 106p are NMOS transistors, and the second diffusion region 112p is defined such that transistors 104p and 108p are PMOS transistors.", "In another embodiment, the first diffusion region 110p is defined such that transistors 102p and 106p are PMOS transistors, and the second diffusion region 112p is defined such that transistors 104p and 108p are NMOS transistors.", "Additionally, the separation distance 114p between the first and second diffusion regions 110p, 112p can vary depending on the requirements of the layout and the area required for connection of the cross-coupled transistors between the first and second diffusion regions 110p, 112p.", "In the exemplary embodiments disclosed herein, it should be understood that diffusion regions are not restricted in size.", "In other words, any given diffusion region can be sized in an arbitrary manner as required to satisfy electrical and/or layout requirements.", "Additionally, any given diffusion region can be shaped in an arbitrary manner as required to satisfy electrical and/or layout requirements.", "Additionally, as discussed above, in various embodiments a cross-coupled transistor configuration can utilize physically separate n-channel diffusion regions and/or physically separate p-channel diffusion regions.", "More specifically, the two N-MOS transistors of the cross-coupled transistor configuration can utilize physically separate n-channel diffusion regions, and/or the two P-MOS transistors of the cross-coupled transistor configuration can utilize physically separate p-channel diffusion regions.", "Also, it should be understood that the four transistors of the cross-coupled transistor configuration, as defined in accordance with the linear gate level, are not required to be the same size.", "In different embodiments, the four transistors of the cross-coupled transistor configuration can either vary in size (transistor width or transistor gate length) or have the same size, depending on the applicable electrical and/or layout requirements.", "Additionally, it should be understood that the four transistors of the cross-coupled transistor configuration are not required to be placed in close proximity to each, although they may be closely placed in some embodiments.", "More specifically, because connections between the transistors of the cross-coupled transistor configuration can be made by routing through as least one higher interconnect level, there is freedom in placement of the four transistors of the cross-coupled transistor configuration relative to each other.", "Although, it should be understood that a proximity of the four transistors of the cross-coupled transistor configuration may be governed in certain embodiments by electrical and/or layout optimization requirements.", "The layout of FIG.", "26 utilizes a linear gate level as described above.", "Specifically, each of linear gate level features 116Ap-116Fp, regardless of function, is defined to extend across the gate level in a common direction and to be devoid of a substantial change in direction along its length.", "Linear gate level features 116Bp, 116Fp, 116Cp, and 116Ep form the gate electrodes of transistors 102p, 104p, 106p, and 108p, respectively.", "The gate electrodes of transistors 106p and 108p are connected through gate contacts 118p and 120p, and through a higher interconnect level feature 101p.", "In one embodiment, the interconnect level feature 101p is a first interconnect level feature, i.e., Metal-1 level feature.", "However, in other embodiments, the interconnect level feature 101p can be a higher interconnect level feature, such as a Metal-2 level feature, or Metal-3 level feature.", "In the illustrated embodiment, to facilitate fabrication (e.g., lithographic resolution) of the interconnect level feature 101p, edges of the interconnect level feature 101p are substantially aligned with edges of neighboring interconnect level features 103p, 105p.", "However, it should be understood that other embodiments may have interconnect level features placed without regard to interconnect level feature alignment or an interconnect level grid.", "Additionally, in the illustrated embodiment, to facilitate fabrication (e.g., lithographic resolution), the gate contacts 118p and 120p are substantially aligned with neighboring contact features 122p and 124p, respectively, such that the gate contacts are placed according to a gate contact grid.", "However, it should be understood that other embodiments may have gate contacts placed without regard to gate contact alignment or gate contact grid.", "The gate electrode of transistor 102p is connected to the gate electrode of transistor 104p through gate contact 126p, through interconnect level (e.g., Metal-1 level) feature 130p, through via 132p, through higher interconnect level (e.g., Metal-2 level) feature 134p, through via 136p, through interconnect level (e.g., Metal-1 level) feature 138p, and through gate contacts 128p.", "Although the illustrated embodiment of FIG.", "26 utilizes the Metal-1 and Metal-2 levels to connect the gate electrodes of transistors 102p and 104p, it should be appreciated that in various embodiment, essentially any combination of interconnect levels can be used to make the connection between the gate electrodes of transistors 102p and 104p.", "It should be appreciated that the cross-coupled transistor layout of FIG.", "26 is defined using four transistors (102p, 104p, 106p, 108p) and four gate contacts (126p, 128p, 118p, 120p).", "Also, the layout embodiment of FIG.", "26 can be characterized in that two of the four gate contacts are placed between the NMOS and PMOS transistors of the cross-coupled transistors, one of the four gate contacts is placed outside of the NMOS transistors, and one of the four gate contacts is placed outside of the PMOS transistors.", "The two gate contacts placed between the NMOS and PMOS transistors are referred to as “inner gate contacts.” The two gate contacts placed outside of the NMOS and PMOS transistors are referred to as “outer gate contacts.” In describing the cross-coupled layout embodiments illustrated in the various Figures herein, including that of FIG.", "26, the direction in which the linear gate level features extend across the layout is referred to as a “vertical direction.” Correspondingly, the direction that is perpendicular to the direction in which the linear gate level features extend across the layout is referred to as a “horizontal direction.” With this in mind, in the cross-coupled layout of FIG.", "26, it can be seen that the transistors 102p and 104p having the outer gate contacts 126p and 128p, respectively, are connected by using two horizontal interconnect level features 130p and 138p, and by using one vertical interconnect level feature 134p.", "It should be understood that the horizontal and vertical interconnect level features 130p, 134p, 138p used to connect the outer gate contacts 126p, 128p can be placed essentially anywhere in the layout, i.e., can be horizontally shifted in either direction away from the cross-coupled transistors 102p, 104p, 106p, 108p, as necessary to satisfy particular layout/routing requirements.", "FIG.", "27 is an illustration showing the exemplary layout of FIG.", "26, with the linear gate electrode features 116Bp, 116Cp, 116Ep, and 116Fp defined to include contact head portions 117Bp, 117Cp, 117Ep, and 117Fp, respectively.", "As previously discussed, a linear gate electrode feature is allowed to have one or more contact head portion(s) along its line of extent, so long as the linear gate electrode feature does not connect directly within the gate level to another linear gate electrode feature having a different, yet parallel, line of extent.", "FIG.", "28 is an illustration showing the cross-coupled transistor layout of FIG.", "26, with the horizontal positions of the inner gate contacts 118p, 120p and outer gate contacts 126p, 128p respectively reversed, in accordance with one embodiment of the present invention.", "It should be understood that essentially any cross-coupled transistor configuration layout defined in accordance with a linear gate level can be represented in an alternate manner by horizontally and/or vertically reversing placement of the gate contacts that are used to connect one or both pairs of the four transistors of the cross-coupled transistor configuration.", "Also, it should be understood that essentially any cross-coupled transistor configuration layout defined in accordance with a linear gate level can be represented in an alternate manner by maintaining gate contact placements and by modifying each routing path used to connect one or both pairs of the four transistors of the cross-coupled transistor configuration.", "FIG.", "29 is an illustration showing the cross-coupled transistor layout of FIG.", "26, with the vertical positions of the inner gate contacts 118p and 120p adjusted to enable alignment of the line end spacings between co-linearly aligned gate level features, in accordance with one embodiment of the present invention.", "Specifically, gate contact 118p is adjusted vertically upward, and gate contact 120p is adjusted vertically downward.", "The linear gate level features 116Bp and 116Ep are then adjusted such that the line end spacing 142p therebetween is substantially vertically centered within area shadowed by the interconnect level feature 101p.", "Similarly, the linear gate level features 116Cp and 116Fp are then adjusted such that the line end spacing 140p therebetween is substantially vertically centered within area shadowed by the interconnect level feature 101p.", "Therefore, the line end spacing 142p is substantially vertically aligned with the line end spacing 140p.", "This vertical alignment of the line end spacings 142p and 140p allows for use of a cut mask to define the line end spacings 142p and 140p.", "In other words, linear gate level features 116Bp and 116Ep are initially defined as a single continuous linear gate level feature, and linear gate level features 116Cp and 116Fp are initially defined as a single continuous linear gate level feature.", "Then, a cut mask is used to remove a portion of each of the single continuous linear gate level features so as to form the line end spacings 142p and 140p.", "It should be understood that although the example layout of FIG.", "29 lends itself to fabrication through use of a cut mask, the layout of FIG.", "29 may also be fabricated without using a cut mask.", "Additionally, it should be understood that each embodiment disclosed herein as being suitable for fabrication through use of a cut mask may also be fabricated without using a cut mask.", "In one embodiment, the gate contacts 118p and 120p are adjusted vertically so as to be edge-aligned with the interconnect level feature 101p.", "However, such edge alignment between gate contact and interconnect level feature is not required in all embodiments.", "For example, so long as the gate contacts 118p and 120p are placed to enable substantial vertical alignment of the line end spacings 142p and 140p, the gate contacts 118p and 120p may not be edge-aligned with the interconnect level feature 101p, although they could be if so desired.", "The above-discussed flexibility with regard to gate contact placement in the direction of extent of the linear gate electrode features is further exemplified in the embodiments of FIGS.", "30 and 54-60.FIG.", "30 is an illustration showing the cross-coupled transistor layout of FIG.", "29, with the horizontal positions of the inner gate contacts 118p, 120p and outer gate contacts 126p, 128p respectively reversed, in accordance with one embodiment of the present invention.", "FIG.", "31 is an illustration showing the cross-coupled transistor layout of FIG.", "26, with the rectangular-shaped interconnect level feature 101p replaced by an S-shaped interconnect level feature 144p, in accordance with one embodiment of the present invention.", "As with the illustrated embodiment of FIG.", "26, the S-shaped interconnect level feature 144p can be defined as a first interconnect level feature, i.e., as a Metal-1 level feature.", "However, in other embodiments, the S-shaped interconnect level feature 144p may be defined within an interconnect level other than the Metal-1 level.", "FIG.", "32 is an illustration showing the cross-coupled transistor layout of FIG.", "31, with the horizontal positions of the inner gate contacts 118p, 120p and outer gate contacts 126p, 128p respectively reversed, in accordance with one embodiment of the present invention.", "It should be appreciated that the S-shaped interconnect level feature 144p is flipped horizontally relative to the embodiment of FIG.", "31 to enable connection of the inner contacts 120p and 118p.", "FIG.", "33 is an illustration showing the cross-coupled transistor layout of FIG.", "31, with a linear gate level feature 146p used to make the vertical portion of the connection between the outer contacts 126p and 128p, in accordance with one embodiment of the present invention.", "Thus, while the embodiment of FIG.", "31 uses vias 132p and 136p, and the higher level interconnect feature 134p to make the vertical portion of the connection between the outer contacts 126p and 128p, the embodiment of FIG.", "33 uses gate contacts 148p and 150p, and the linear gate level feature 146p to make the vertical portion of the connection between the outer contacts 126p and 128p.", "In the embodiment of FIG.", "33, the linear gate level feature 146p serves as a conductor, and is not used to define a gate electrode of a transistor.", "It should be understood that the linear gate level feature 146p, used to connect the outer gate contacts 126p and 128p, can be placed essentially anywhere in the layout, i.e., can be horizontally shifted in either direction away from the cross-coupled transistors 102p, 104p, 106p, 108p, as necessary to satisfy particular layout requirements.", "FIG.", "34 is an illustration showing the cross-coupled transistor layout of FIG.", "33, with the horizontal positions of the inner gate contacts 118p, 120p and outer gate contacts 126p, 128p respectively reversed, in accordance with one embodiment of the present invention.", "FIG.", "35 is an illustration showing the cross-coupled transistor layout of FIG.", "33 defined in connection with a multiplexer (MUX), in accordance with one embodiment of the present invention.", "In contrast to the embodiment of FIG.", "33 which utilizes a non-transistor linear gate level feature 146p to make the vertical portion of the connection between the outer contacts 126p and 128p, the embodiment of FIG.", "35 utilizes a select inverter of the MUX to make the vertical portion of the connection between the outer contacts 126p and 128p, wherein the select inverter of the MUX is defined by transistors 152p and 154p.", "More specifically, transistor 102p of the cross-coupled transistors is driven through transistor 152p of the select inverter.", "Similarly, transistor 104p of the cross-coupled transistors is driven through transistor 154p of the select inverter.", "It should be understood that the linear gate level feature 116Gp, used to define the transistors 152p and 154p of the select inverter and used to connect the outer gate contacts 126p and 128p, can be placed essentially anywhere in the layout, i.e., can be horizontally shifted in either direction away from the cross-coupled transistors 102p, 104p, 106p, 108p, as necessary to satisfy particular layout requirements.", "FIG.", "36 is an illustration showing the cross-coupled transistor layout of FIG.", "35, with the horizontal positions of the inner gate contacts 118p, 120p and outer gate contacts 126p, 128p respectively reversed, in accordance with one embodiment of the present invention.", "FIG.", "37 is an illustration showing a latch-type cross-coupled transistor layout, in accordance with one embodiment of the present invention.", "The latch-type cross-coupled transistor layout of FIG.", "37 is similar to that of FIG.", "33, with the exception that the gate widths of transistors 102p and 108p are reduced relative to the gate widths of transistors 106p and 104p.", "Because transistors 102p and 108p perform a signal keeping function as opposed to a signal driving function, the gate widths of transistors 102p and 108p can be reduced.", "As with the embodiment of FIG.", "33, the outer gate contact 126p is connected to the outer gate contact 128p by way of the interconnect level feature 130p, the gate contact 148p, the linear gate level feature 146p, the gate contact 150p, and the interconnect level feature 138p.", "Also, because of the reduced size of the diffusion regions 110p and 112p for the keeping transistors 102p and 108p, the inner gate contacts 120p and 118p can be vertically aligned.", "Vertical alignment of the inner gate contacts 120p and 118p may facilitate contact fabrication, e.g., contact lithographic resolution.", "Also, vertical alignment of the inner gate contacts 120p and 118p allows for use of simple linear-shaped interconnect level feature 156p to connect the inner gate contacts 120p and 118p.", "Also, vertical alignment of the inner gate contacts 120p and 118p allows for increased vertical separation of the line end spacings 142p and 140p, which may facilitate creation of the line end spacings 142p and 140p when formed using separate cut shapes in a cut mask.", "FIG.", "38 is an illustration showing the cross-coupled transistor layout of FIG.", "37, with the horizontal positions of the inner gate contacts 120p, 118p and outer gate contacts 126p, 128p respectively reversed, in accordance with one embodiment of the present invention.", "FIG.", "39 is an illustration showing the cross-coupled transistor layout of FIG.", "37, with the interconnect level feature 134p used to make the vertical portion of the connection between the outer contacts 126p and 128p, in accordance with one embodiment of the present invention.", "Thus, while the embodiment of FIG.", "37 uses gate contacts 148p and 150p, and the linear gate level feature 146p to make the vertical portion of the connection between the outer contacts 126p and 128p, the embodiment of FIG.", "39 uses vias 132p and 136p, and the interconnect level feature 134p to make the vertical portion of the connection between the outer contacts 126p and 128p.", "In one embodiment of FIG.", "39, the interconnect level feature 134p is defined as second interconnect level feature, i.e., Metal-2 level feature.", "However, in other embodiments, the interconnect level feature 134p can be defined within an interconnect level other than the second interconnect level.", "It should be understood that the interconnect level feature 134p, used to connect the outer gate contacts 126p and 128p, can be placed essentially anywhere in the layout, i.e., can be horizontally shifted in either direction away from the cross-coupled transistors 102p, 104p, 106p, 108p, as necessary to satisfy layout requirements.", "FIG.", "40 is an illustration showing the cross-coupled transistor layout of FIG.", "39, with the horizontal positions of the inner gate contacts 120p, 118p and outer gate contacts 126p, 128p respectively reversed, in accordance with one embodiment of the present invention.", "FIG.", "41 is an illustration showing the latch-type cross-coupled transistor layout of FIG.", "37, defined in connection with a MUX/latch, in accordance with one embodiment of the present invention.", "In contrast to the embodiment of FIG.", "37 which utilizes a non-transistor linear gate level feature 146p to make the vertical portion of the connection between the outer contacts 126p and 128p, the embodiment of FIG.", "41 utilizes a select/clock inverter of the MUX/latch to make the vertical portion of the connection between the outer contacts 126p and 128p, wherein the select/clock inverter of the MUX/latch is defined by transistors 160p and 162p.", "More specifically, transistor 102p of the cross-coupled transistors is driven through transistor 160p of the select/clock inverter.", "Similarly, transistor 104p of the cross-coupled transistors is driven through transistor 162p of the select/clock inverter.", "It should be understood that the linear gate level feature 164p, used to define the transistors 160p and 162p of the select/clock inverter and used to connect the outer gate contacts 126p and 128p, can be placed essentially anywhere in the layout, i.e., can be horizontally shifted in either direction away from the cross-coupled transistors 102p, 104p, 106p, 108p, as necessary to satisfy particular layout requirements.", "FIG.", "42 is an illustration showing the cross-coupled transistor layout of FIG.", "41, with the horizontal positions of the inner gate contacts 118p, 120p and outer gate contacts 126p, 128p respectively reversed, in accordance with one embodiment of the present invention.", "FIG.", "43 is an illustration showing the latch-type cross-coupled transistor layout of FIG.", "37, defined to have the outer gate contacts 126p and 128p connected using a single interconnect level, in accordance with one embodiment of the present invention.", "In contrast to the embodiment of FIG.", "37 which utilizes a non-transistor linear gate level feature 146p to make the vertical portion of the connection between the outer contacts 126p and 128p, the embodiment of FIG.", "43 uses a single interconnect level to make the horizontal and vertical portions of the connection between the outer contacts 126p and 128p.", "The gate electrode of transistor 102p is connected to the gate electrode of transistor 104p through gate contact 126p, through horizontal interconnect level feature 166p, through vertical interconnect level feature 168p, through horizontal interconnect level feature 170p, and through gate contact 128p.", "In one embodiment, the interconnect level features 166p, 168p, and 170p are first interconnect level features (Metal-1 features).", "However, in other embodiments, the interconnect level features 166p, 168p, and 170p can be defined collectively within any other interconnect level.", "FIG.", "44 is an illustration showing the cross-coupled transistor layout of FIG.", "43, with the horizontal positions of the inner gate contacts 118p, 120p and outer gate contacts 126p, 128p respectively reversed, in accordance with one embodiment of the present invention.", "FIG.", "45 is an illustration showing a cross-coupled transistor layout in which all four gate contacts 126p, 128p, 118p, and 120p of the cross-coupled coupled transistors are placed therebetween, in accordance with one embodiment of the present invention.", "Specifically, the gate contacts 126p, 128p, 118p, and 120p of the cross-coupled coupled transistors are placed vertically between the diffusion regions 110p and 112p that define the cross-coupled coupled transistors.", "The gate electrode of transistor 102p is connected to the gate electrode of transistor 104p through gate contact 126p, through horizontal interconnect level feature 172p, through vertical interconnect level feature 174p, through horizontal interconnect level feature 176p, and through gate contact 128p.", "In one embodiment, the interconnect level features 172p, 174p, and 176p are first interconnect level features (Metal-1 features).", "However, in other embodiments, the interconnect level features 172p, 174p, and 176p can be defined collectively within any other interconnect level.", "The gate electrode of transistor 108p is connected to the gate electrode of transistor 106p through gate contact 120p, through S-shaped interconnect level feature 144p, and through gate contact 118p.", "The S-shaped interconnect level feature 144p can be defined within any interconnect level.", "In one embodiment, the S-shaped interconnect level feature is defined within the first interconnect level (Metal-1 level).", "FIG.", "45A shows an annotated version of FIG.", "45.The features depicted in FIG.", "45A are exactly the same as the features depicted in FIG.", "45.FIG.", "45A shows a first conductive gate level structure 45a01, a second conductive gate level structure 45a03, a third conductive gate level structure 45a05, a fourth conductive gate level structure 45a07, a fifth conductive gate level structure 45a09, and a sixth conductive gate level structure 45a11, each extending lengthwise in a parallel direction.", "As shown in FIG.", "45A, the second conductive gate level structure 45a03 and the third conductive gate level structure 45a05 are positioned in an end-to-end spaced apart manner and are separated from each other by a first end-to-end spacing 45a25.As shown in FIG.", "45A, the fourth conductive gate level structure 45a07 and the fifth conductive gate level structure 45a09 are positioned in an end-to-end spaced apart manner and are separated from each other by a second end-to-end spacing 45a27.As shown in FIG.", "45A, the second conductive gate level structure 45a03 is defined to have an inner extension portion 45a19 over the inner non-diffusion region between the diffusion regions 110p and 112p.", "As shown in FIG.", "45A, the third conductive gate level structure 45a05 is defined to have an inner extension portion 45a17 over the inner non-diffusion region between the diffusion regions 110p and 112p.", "As shown in FIG.", "45A, the fourth conductive gate level structure 45a07 is defined to have an inner extension portion 45a23 over the inner non-diffusion region between the diffusion regions 110p and 112p.", "As shown in FIG.", "45A, the fifth conductive gate level structure 45a09 is defined to have an inner extension portion 45a21 over the inner non-diffusion region between the diffusion regions 110p and 112p.", "As shown in FIG.", "45A, a first electrical connection 45a13 (as denoted by the heavy solid black line) is formed between the second conductive gate level structure 45a03 and the fifth conductive gate level structure 45a09.As shown in FIG.", "45A, a second electrical connection 45a15 (as denoted by the heavy dashed black line) is formed between the third conductive gate level structure 45a05 and the fourth conductive gate level structure 45a07.FIG.", "45B shows an annotated version of FIG.", "45.The features depicted in FIG.", "45B are exactly the same as the features depicted in FIG.", "45.As shown in FIG.", "45B, the second conductive gate level structure 45a03 extends a distance 45a33 away from the contact 120p and in the parallel direction away from the gate electrode of transistor 108p.", "As shown in FIG.", "45B, the third conductive gate level structure 45a05 extends a distance 45a31 away from the contact 126p and in the parallel direction away from the gate electrode of transistor 102p.", "As shown in FIG.", "45B, the fourth conductive gate level structure 45a07 extends a distance 45a37 away from the contact 128p and in the parallel direction away from the gate electrode of transistor 104p.", "As shown in FIG.", "45B, the fifth conductive gate level structure 45a09 extends a distance 45a35 away from the contact 118p and in the parallel direction away from the gate electrode of transistor 106p.", "FIG.", "46 is an illustration showing the cross-coupled transistor layout of FIG.", "45, with multiple interconnect levels used to connect the gate contacts 126p and 128p, in accordance with one embodiment of the present invention.", "The gate electrode of transistor 102p is connected to the gate electrode of transistor 104p through gate contact 126p, through horizontal interconnect level feature 172p, through via 180p, through vertical interconnect level feature 178p, through via 182p, through horizontal interconnect level feature 176p, and through gate contact 128p.", "In one embodiment, the horizontal interconnect level features 172p and 176p are defined within the same interconnect level, e.g., Metal-1 level, and the vertical interconnect level feature 178p is defined within a higher interconnect level, e.g., Metal-2 level.", "It should be understood, however, that in other embodiments each of interconnect level features 172p, 178p, and 176p can be defined in separate interconnect levels.", "FIG.", "47 is an illustration showing the cross-coupled transistor layout of FIG.", "45, with increased vertical separation between line end spacings 184p and 186p, in accordance with one embodiment of the present invention.", "The increased vertical separation between line end spacings 184p and 186p can facilitate creation of the line end spacings 184p and 186p when formed using separate cut shapes in a cut mask.", "FIG.", "48 is an illustration showing the cross-coupled transistor layout of FIG.", "45, using an L-shaped interconnect level feature 188p to connect the gate contacts 120p and 118p, in accordance with one embodiment of the present invention.", "FIG.", "49 is an illustration showing the cross-coupled transistor layout of FIG.", "48, with the horizontal position of gate contacts 126p and 118p reversed, and with the horizontal position of gate contacts 120p and 128p reversed, in accordance with one embodiment of the present invention.", "FIG.", "50 is an illustration showing the cross-coupled transistor layout of FIG.", "48, with increased vertical separation between line end spacings 184p and 186p, in accordance with one embodiment of the present invention.", "The increased vertical separation between line end spacings 184p and 186p can facilitate creation of the line end spacings 184p and 186p when formed using separate cut shapes in a cut mask.", "FIG.", "51 is an illustration showing the cross-coupled transistor layout of FIG.", "45, in which gate contacts 120p and 118p are vertically aligned, in accordance with one embodiment of the present invention.", "A linear-shaped interconnect level feature 190p is used to connect the vertically aligned gate contacts 120p and 118p.", "Also, in the embodiment of FIG.", "51, an increased vertical separation between line end spacings 184p and 186p is provided to facilitate creation of the line end spacings 184p and 186p when formed using separate cut shapes in a cut mask, although use of a cut mask to fabricate the layout of FIG.", "51 is not specifically required.", "FIG.", "51A shows an annotated version of FIG.", "51.The features depicted in FIG.", "51A are exactly the same as the features depicted in FIG.", "51.FIG.", "51A shows a first conductive gate level structure 51a01, a second conductive gate level structure 51a03, a third conductive gate level structure 51a05, a fourth conductive gate level structure 51a07, a fifth conductive gate level structure 51a09, and a sixth conductive gate level structure 51a11, each extending lengthwise in a parallel direction.", "As shown in FIG.", "51A, the second conductive gate level structure 51a03 and the third conductive gate level structure 51a05 are positioned in an end-to-end spaced apart manner and are separated from each other by a first end-to-end spacing 51a25.As shown in FIG.", "51A, the fourth conductive gate level structure 51a07 and the fifth conductive gate level structure 51a09 are positioned in an end-to-end spaced apart manner and are separated from each other by a second end-to-end spacing 51a27.As shown in FIG.", "51A, the second conductive gate level structure 51a03 is defined to have an inner extension portion 51a19 over the inner non-diffusion region between the diffusion regions 110p and 112p.", "As shown in FIG.", "51A, the third conductive gate level structure 51a05 is defined to have an inner extension portion 51a17 over the inner non-diffusion region between the diffusion regions 110p and 112p.", "As shown in FIG.", "51A, the fourth conductive gate level structure 51a07 is defined to have an inner extension portion 51a23 over the inner non-diffusion region between the diffusion regions 110p and 112p.", "As shown in FIG.", "51A, the fifth conductive gate level structure 51a09 is defined to have an inner extension portion 51a21 over the inner non-diffusion region between the diffusion regions 110p and 112p.", "As shown in FIG.", "51A, a first electrical connection 51a13 (as denoted by the heavy solid black line) is formed between the second conductive gate level structure 51a03 and the fifth conductive gate level structure 51a09.As shown in FIG.", "51A, a second electrical connection 51a15 (as denoted by the heavy dashed black line) is formed between the third conductive gate level structure 51a05 and the fourth conductive gate level structure 51a07.FIG.", "51B shows an annotated version of FIG.", "51.The features depicted in FIG.", "51B are exactly the same as the features depicted in FIG.", "51.As shown in FIG.", "51B, the second conductive gate level structure 51a03 extends a distance 51a33 away from the contact 120p and in the parallel direction away from the gate electrode of transistor 108p.", "As shown in FIG.", "51B, the third conductive gate level structure 51a05 extends a distance 51a31 away from the contact 126p and in the parallel direction away from the gate electrode of transistor 102p.", "As shown in FIG.", "51B, the fourth conductive gate level structure 51a07 extends a distance 51a37 away from the contact 128p and in the parallel direction away from the gate electrode of transistor 104p.", "As shown in FIG.", "51B, the fifth conductive gate level structure 51a09 extends a distance 51a35 away from the contact 118p and in the parallel direction away from the gate electrode of transistor 106p.", "FIG.", "52 is an illustration showing the cross-coupled transistor layout of FIG.", "45, in which a linear-shaped interconnect level feature 192p is used to connect the non-vertically-aligned gate contacts 120p and 118p, in accordance with one embodiment of the present invention.", "It should be appreciated that the linear-shaped interconnect level feature 192p is stretched vertically to cover both of the gate contacts 120p and 118p.", "FIG.", "53 is an illustration showing the cross-coupled transistor layout of FIG.", "52, with multiple interconnect levels used to connect the gate contacts 126p and 128p, in accordance with one embodiment of the present invention.", "The gate electrode of transistor 102p is connected to the gate electrode of transistor 104p through gate contact 126p, through horizontal interconnect level feature 172p, through via 180p, through vertical interconnect level feature 178p, through via 182p, through horizontal interconnect level feature 176p, and through gate contact 128p.", "In one embodiment, the horizontal interconnect level features 172p and 176p are defined within the same interconnect level, e.g., Metal-1 level, and the vertical interconnect level feature 178p is defined within a higher interconnect level, e.g., Metal-2 level.", "It should be understood, however, that in other embodiments each of interconnect level features 172p, 178p, and 176p can be defined in separate interconnect levels.", "FIG.", "54 is an illustration showing the cross-coupled transistor layout of FIG.", "53, with the vertical positions of gate contacts 118p and 120p adjusted to enable alignment of the line end spacings between co-linearly aligned gate level features, in accordance with one embodiment of the present invention.", "Specifically, gate contact 118p is adjusted vertically upward, and gate contact 120p is adjusted vertically downward.", "The linear gate level features 116Bp and 116Ep are then adjusted such that the line end spacing 184p therebetween is substantially vertically centered within area shadowed by the interconnect level feature 192p.", "Similarly, the linear gate level features 116Cp and 116Fp are then adjusted such that the line end spacing 186p therebetween is substantially vertically centered within area shadowed by the interconnect level feature 192p.", "Therefore, the line end spacing 184p is substantially vertically aligned with the line end spacing 186p.", "This vertical alignment of the line end spacings 184p and 186p allows for use of a cut mask to define the line end spacings 184p and 186p.", "In other words, linear gate level features 116Bp and 116Ep are initially defined as a single continuous linear gate level feature, and linear gate level features 116Cp and 116Fp are initially defined as a single continuous linear gate level feature.", "Then, a cut mask is used to remove a portion of each of the single continuous linear gate level features so as to form the line end spacings 184p and 186p.", "As previously discussed with regard to FIG.", "29, although edge-alignment between the gate contacts 118p, 120p and the interconnect level feature 192p can be utilized in one embodiment, it should be understood that such edge-alignment between gate contact and interconnect level feature is not required in all embodiments.", "FIG.", "55 is an illustration showing a cross-coupled transistor layout in which the four gate contacts 126p, 128p, 120p, and 118p are placed within three consecutive horizontal tracks of an interconnect level, in accordance with one embodiment of the present invention.", "The gate electrode of transistor 102p is connected to the gate electrode of transistor 104p through gate contact 126p, through horizontal interconnect level feature 402p, through gate contact 418p, through vertical gate level feature 404p, through gate contact 416p, through horizontal interconnect level feature 424p, and through gate contact 128p.", "The vertical gate level feature 404p represents a common node to which the gate electrodes of transistors 426p and 428p are connected.", "It should be understood that the vertical gate level feature 404p can be shifted left or right relative to the cross-coupled transistors 102p, 104p, 106p, 108p, as necessary for layout purposes.", "Also, the gate electrode of transistor 106p is connected to the gate electrode of transistor 108p through gate contact 118p, through horizontal interconnect level feature 190p, and through gate contact 120p.", "It should be appreciated that placement of gate contacts 126p, 128p, 120p, and 118p within three consecutive horizontal interconnect level tracks allows for an interconnect level track 414p to pass through the cross-coupled transistor layout.", "Also, it should be understood that the interconnect level features 402p, 424p, and 190p can be defined in the same interconnect level or in different interconnect levels.", "In one embodiment, each of the interconnect level features 402p, 424p, and 190p is defined in a first interconnect level (Metal-1 level).", "FIG.", "56 is an illustration showing the cross-coupled transistor layout of FIG.", "55, in which a non-transistor gate level feature 430p is used to make the vertical portion of the connection between gate contacts 126p and 126p, in accordance with one embodiment of the present invention.", "The gate electrode of transistor 102p is connected to the gate electrode of transistor 104p through gate contact 126p, through horizontal interconnected level feature 402p, through gate contact 418p, through vertical non-transistor gate level feature 430p, through gate contact 416p, through horizontal interconnect level feature 424p, and through gate contact 128p.", "FIG.", "57 is an illustration showing a cross-coupled transistor layout in which the four gate contacts 126p, 128p, 120p, and 118p are placed within three consecutive horizontal tracks of an interconnect level, and in which multiple interconnect levels are used to connect the gate contacts 126p and 128p, in accordance with one embodiment of the present invention.", "The gate electrode of transistor 102p is connected to the gate electrode of transistor 104p through gate contact 126p, through horizontal interconnect level feature 432p, through via 434p, through vertical interconnect level feature 436p, through via 438p, through horizontal interconnect level feature 440p, and through gate contact 128p.", "The vertical interconnect level feature 436p is defined within an interconnect level different from the interconnect level in which the horizontal interconnect level features 432p and 440p are defined.", "In one embodiment, the horizontal interconnect level features 432p and 440p are defined within a first interconnect level (Metal-1 level), and the vertical interconnect level feature 436p is defined within a second interconnect level (Metal-2 level).", "It should be understood that the vertical interconnect level feature 436p can be shifted left or right relative to the cross-coupled transistors 102p, 104p, 106p, 108p, as necessary for layout purposes.", "Also, the gate electrode of transistor 106p is connected to the gate electrode of transistor 108p through gate contact 118p, through horizontal interconnect level feature 190p, and through gate contact 120p.", "FIG.", "58 is an illustration showing the cross-coupled transistor layout of FIG.", "57, in which the gate contacts 126Ap, 118Ap, 120Ap, and 128Ap are extended in the vertical direction to provided additional overlap with their respective underlying gate level feature, in accordance with one embodiment of the present invention.", "The additional overlap of the gate level features by the gate contacts 126Ap, 118Ap, 120Ap, and 128Ap may be provided to satisfy design rules.", "FIG.", "59 is an illustration showing the cross-coupled transistor layout of FIG.", "57, in which the gate contacts 126p, 118p, 120p, and 128p are placed within four consecutive interconnect level tracks with an intervening vacant interconnect level track 704p, in accordance with one embodiment of the present invention.", "The gate electrode of transistor 102p is connected to the gate electrode of transistor 104p through gate contact 126p, through horizontal interconnect level feature 432p, through via 434p, through vertical interconnect level feature 436p, through via 438p, through horizontal interconnect level feature 440p, and through gate contact 128p.", "The gate electrode of transistor 106p is connected to the gate electrode of transistor 108p through gate contact 118p, through L-shaped interconnect level feature 450p, and through gate contact 120p.", "As shown at locations 706p and 708p, the L-shaped interconnect level feature 450p can be extended beyond the gate contacts 120p and 118p to provide sufficient overlap of the gate contacts by the L-shaped interconnect level feature 450p, as needed to satisfy design rules.", "FIG.", "59A shows an annotated version of FIG.", "59.The features depicted in FIG.", "59A are exactly the same as the features depicted in FIG.", "59.FIG.", "59A shows a first conductive gate level structure 59a01, a second conductive gate level structure 59a03, a third conductive gate level structure 59a05, a fourth conductive gate level structure 59a07, a fifth conductive gate level structure 59a09, and a sixth conductive gate level structure 59a11, each extending lengthwise in a parallel direction.", "As shown in FIG.", "59A, the second conductive gate level structure 59a03 and the third conductive gate level structure 59a05 are positioned in an end-to-end spaced apart manner and are separated from each other by a first end-to-end spacing 59a25.As shown in FIG.", "59A, the fourth conductive gate level structure 59a07 and the fifth conductive gate level structure 59a09 are positioned in an end-to-end spaced apart manner and are separated from each other by a second end-to-end spacing 59a27.As shown in FIG.", "59A, the second conductive gate level structure 59a03 is defined to have an inner extension portion 59a19 over the inner non-diffusion region between the diffusion regions 110p and 112p.", "As shown in FIG.", "59A, the third conductive gate level structure 59a05 is defined to have an inner extension portion 59a17 over the inner non-diffusion region between the diffusion regions 110p and 112p.", "As shown in FIG.", "59A, the fourth conductive gate level structure 59a07 is defined to have an inner extension portion 59a23 over the inner non-diffusion region between the diffusion regions 110p and 112p.", "As shown in FIG.", "59A, the fifth conductive gate level structure 59a09 is defined to have an inner extension portion 59a21 over the inner non-diffusion region between the diffusion regions 110p and 112p.", "As shown in FIG.", "59A, a first electrical connection 59a13 (as denoted by the heavy solid black line) is formed between the second conductive gate level structure 59a03 and the fifth conductive gate level structure 59a09.As shown in FIG.", "59A, a second electrical connection 59a15 (as denoted by the heavy dashed black line) is formed between the third conductive gate level structure 59a05 and the fourth conductive gate level structure 59a07.FIG.", "59B shows an annotated version of FIG.", "59.The features depicted in FIG.", "59B are exactly the same as the features depicted in FIG.", "59.As shown in FIG.", "59B, the second conductive gate level structure 59a03 extends a distance 59a33 away from the contact 120p and in the parallel direction away from the gate electrode of transistor 108p.", "As shown in FIG.", "59B, the third conductive gate level structure 59a05 extends a distance 59a31 away from the contact 126p and in the parallel direction away from the gate electrode of transistor 102p.", "As shown in FIG.", "59B, the fourth conductive gate level structure 59a07 extends a distance 59a37 away from the contact 128p and in the parallel direction away from the gate electrode of transistor 104p.", "As shown in FIG.", "59B, the fifth conductive gate level structure 59a09 extends a distance 59a35 away from the contact 118p and in the parallel direction away from the gate electrode of transistor 106p.", "FIG.", "60 is an illustration showing the cross-coupled transistor layout of FIG.", "59, with a variation in the overlap of the gate contact 120p by the L-shaped interconnect level feature 450p, in accordance with one embodiment of the present invention.", "The overlap region 709p is turned horizontally so as to align with the horizontal interconnect level feature 440p.", "FIGS.", "61-94 are illustrations showing variants of the cross-coupled transistor layouts of FIGS.", "26 and 28-60, respectively.", "As previously mentioned, essentially any cross-coupled transistor layout defined in accordance with a linear gate level can be represented in an alternate manner by horizontally and/or vertically reversing placement of the gate contacts that are used to connect one or both pairs of the four transistors of the cross-coupled transistor configuration.", "Also, essentially any cross-coupled transistor layout defined in accordance with a linear gate level can be represented in an alternate manner by maintaining gate contact placements and by modifying each routing path used to connect one or both pairs of the four transistors of the cross-coupled transistor configuration.", "FIGS.", "95-99 show exemplary cross-coupled transistor layouts defined in accordance with the linear gate level, in which a folded transistor layout technique is implemented.", "A folded transistor is defined as a plurality of transistors whose gate electrodes share an identical electrical connectivity configuration.", "In other words, each individual transistor of a given folded transistor has its gate electrode connected to a common node and is defined to electrically interface with a common diffusion region.", "It should be understood that although each individual transistor of a given folded transistor has its gate electrode connected to a common diffusion region, it is not required that the common diffusion region be continuous, i.e., monolithic.", "For example, diffusion regions that are of the same type but are physically separated from each other, and have an electrical connection to a common output node, and share a common source/drain, satisfy the common diffusion region characteristic of the folded transistor.", "In the example layout of FIG.", "95, a first pair of the cross-coupled transistors is defined by a folded transistor 6901Ap/6901Bp and by a transistor 6903p.", "Each of the individual transistors 6901Ap and 6901Bp that form the folded transistor is connected to a common diffusion region 6905p and has its gate electrode connected to a common node 6907p through respective gate contacts 6909Ap and 6909Bp.", "The gate contacts 6909Ap and 6909Bp are connected to a gate contact 6921p of transistor 6903p by way of a metal 1 interconnect level feature 6911p, a contact 6913p, a gate level feature 6915p, a contact 6917p, and a metal 1 interconnect level feature 6919p.", "A second pair of the cross-coupled transistors is defined by a folded transistor 6923Ap/6923Bp and by a transistor 6925p.", "Each of the individual transistors 6923Ap and 6923Bp that form the folded transistor is connected to a common diffusion region 6927p and has its gate electrode connected to a common node 6929p through respective gate contacts 6931Ap and 6931Bp.", "The gate contacts 6931Ap and 6931Bp are connected to a gate contact 6933p of transistor 6925p by way of a metal 1 interconnect level feature 6935p.", "Transistors 6901Ap, 6901Bp, and 6925p are electrically interfaced with the diffusion region 6905p.", "Also, transistors 6923Ap, 6923Bp, and 6903p are electrically interfaced with the diffusion region 6927p.", "Additionally, although not explicitly shown, diffusion regions 6905p and 6927p are connected to a common output node.", "FIG.", "96 shows a variant of the cross-coupled transistor layout of FIG.", "95, in which the connection between the folded transistor 6901Ap/6901Bp and the transistor 6903p is made using an alternate conductive path through the chip.", "Specifically, the gate contacts 6909Ap and 6909Bp are connected to the gate contact 6921p of transistor 6903p by way of a metal 1 interconnect level feature 7001p, a via 7003p, a metal 2 interconnect level feature 7005p, a via 7007p, and a metal 1 interconnect level feature 7009p.", "In the example layout of FIG.", "97, a first pair of the cross-coupled transistors is defined by a folded transistor 7101Ap/7101Bp and by a folded transistor 7103Ap/7103Bp.", "Gate contacts 7105Ap and 7105Bp are connected to gate contacts 7107Ap and 7107Bp by way of a metal 1 interconnect level feature 7109p, a via 7111p, a metal 2 interconnect level feature 7113p, a via 7115p, and a metal 1 interconnect level feature 7117p.", "A second pair of the cross-coupled transistors is defined by a folded transistor 7119Ap/7119Bp and by a folded transistor 7121Ap/7121Bp.", "Gate contacts 7123Ap and 7123Bp are connected to gate contacts 7125Ap and 7125Bp by way of a metal 1 interconnect level feature 7127p, a via 7129p, a metal 2 interconnect level feature 7131p, a via 7133p, a metal 1 interconnect level feature 7135p, a via 7137p, a metal 2 interconnect level feature 7139p, a via 7141p, and a metal 1 interconnect level feature 7143p.", "Transistors 7101Ap, 7101Bp, 7121Ap, and 7121Bp are electrically interfaced with diffusion region 7145p.", "Also, transistors 7119Ap, 7119Bp, 7103Ap, and 7103Bp are electrically interfaced with diffusion region 7147p.", "Additionally, although not explicitly shown, portions of diffusion regions 7145p and 7147p which are electrically interfaced with the transistors 7101Ap, 7101Bp, 7103Ap, 7103Bp, 7119Ap, 7119Bp, 7121Ap, and 7121Bp are connected to a common output node.", "FIG.", "98 shows a variant of the cross-coupled transistor layout of FIG.", "97, in which the electrical connections between the cross-coupled transistors are made using an alternate conductive paths through the chip.", "Specifically, the gate contacts 7105Ap and 7105Bp are connected to the gate contacts 7107Ap and 7107Bp by way of a metal 1 interconnect level feature 7201p, a contact 7203p, a gate level feature 7205p, a contact 7207p, and a metal 1 interconnect level feature 7209p.", "Also, the gate contacts 7123Ap and 7123Bp are connected to the gate contacts 7125Ap and 7125Bp by way of a metal 1 interconnect level feature 7211p.", "In this embodiment, the metal 1 interconnect level in unrestricted with regard to bends in conductive features.", "Therefore, the metal 1 interconnect level feature 7211p can be defined to “snake” through the metal 1 interconnect level to make the required cross-coupled transistor connections, as permitted by surrounding layout features.", "FIG.", "99 shows a variant of the cross-coupled transistor layout of FIG.", "97, in which the connection between the folded transistor 7101Ap/7101Bp and the folded transistor 7103Ap/7103Bp is made using an alternate conductive path through the chip.", "Specifically, the gate contacts 7105Ap and 7105Bp are connected to the gate contacts 7107Ap and 7107Bp by way of the metal 1 interconnect level feature 7201p, the contact 7203p, the gate level feature 7205p, the contact 7207p, and the metal 1 interconnect level feature 7209p.", "It should be understood that the cross-coupled transistor layouts utilizing folded transistors as shown in FIGS.", "95-99 are provided by way of example, and should not be construed as fully inclusive.", "In each FIGS.", "26-99, the cross-coupled transistor connections have been described by tracing through the various conductive features of each conductive path used to connect each pair of transistors in the cross-coupled layout.", "It should be appreciated that the conductive path used to connect each pair of transistors in a given cross-coupled layout can traverse through conductive features any number of levels of the chip, utilizing any number of contacts and vias as necessary.", "For ease of description with regard to FIGS.", "100 through 192, the conductive paths used to connect the various NMOS/PMOS transistor pairs in each cross-coupled transistor layout are identified by heavy black lines drawn over the corresponding layout features.", "As previously mentioned, FIGS.", "26-99 do not explicitly show connection of the diffusion regions of the cross-coupled transistors to a common node, although this connection is present.", "FIGS.", "100-111 show exemplary cross-coupled transistor layouts in which the n-type and p-type diffusion regions of the cross-coupled transistors are shown to be electrically connected to a common node.", "The conductive path used to connect the diffusion regions of the cross-coupled transistors to the common node in each of FIGS.", "100-111 is identified by a heavy black dashed line drawn over the corresponding layout features.", "For ease of description, FIGS.", "112-148 do not show the heavy black dashed line corresponding to the conductive path used to connect the diffusion regions of the cross-coupled transistors to the common node.", "However, some of FIGS.", "112-148 do show the layout features associated with the conductive path, or a portion thereof, used to connect the diffusion regions of the cross-coupled transistors to the common node.", "Again, although not explicitly shown in each of FIGS.", "26-148, it should be understood that each of the exemplary cross-coupled transistor layout includes a conductive path that connects the diffusion regions of the cross-coupled transistors to a common output node.", "FIG.", "68A shows an annotated version of FIG.", "68.The features depicted in FIG.", "68A are exactly the same as the features depicted in FIG.", "68.FIG.", "68A shows a first conductive gate level structure 68a02, a second conductive gate level structure 68a04, a third conductive gate level structure 68a06, a fourth conductive gate level structure 68a08, a fifth conductive gate level structure 68a10, a sixth conductive gate level structure 68a12, and a seventh conductive gate level structure 68a14, each extending lengthwise in a parallel direction.", "As shown in FIG.", "68A, the first conductive gate level structure 68a02 forms a gate electrode of transistor 68a01 and a gate electrode of transistor 68a11.As shown in FIG.", "68A, the second conductive gate level structure 68a04 forms a gate electrode of transistor 68a03.As shown in FIG.", "68A, the third conductive gate level structure 68a06 forms a gate electrode of transistor 68a13.As shown in FIG.", "68A, the fourth conductive gate level structure 68a08 forms a gate electrode of transistor 68a05.As shown in FIG.", "68A, the fifth conductive gate level structure 68a10 forms a gate electrode of transistor 68a15.As shown in FIG.", "68A, the sixth conductive gate level structure 68a12 forms a gate electrode of transistor 68a07 and a gate electrode of transistor 68a17.As shown in FIG.", "68A, the seventh conductive gate level structure 68a14 forms a gate electrode of transistor 68a09 and a gate electrode of transistor 68a19.As shown in FIG.", "68A, the second conductive gate level structure 68a04 has an inner end position 68a27.As shown in FIG.", "68A, the third conductive gate level structure 68a06 has an inner end position 68a25.As shown in FIG.", "68A, the fourth conductive gate level structure 68a08 has an inner end position 68a31.As shown in FIG.", "68A, the fifth conductive gate level structure 68a10 has an inner end position 68a29.As shown in FIG.", "68A, a first electrical connection 68a23 (as denoted by the heavy solid black line) is formed between the second conductive gate level structure 68a04 and the fifth conductive gate level structure 68a10, and through an interconnect structure 68a16 formed in a single interconnect level.", "As shown in FIG.", "68A, a second electrical connection 68a21 (as denoted by the heavy dashed black line) is formed between the third conductive gate level structure 68a06 and the fourth conductive gate level structure 68a08.FIG.", "68B shows an annotated version of FIG.", "68.The features depicted in FIG.", "68B are exactly the same as the features depicted in FIG.", "68.As shown in FIG.", "68B, the second conductive gate level structure 68a04 and the third conductive gate level structure 68a06 are positioned in an end-to-end spaced apart manner and are separated from each other by a first end-to-end spacing 68a41.As shown in FIG.", "68B, the fourth conductive gate level structure 68a08 and the fifth conductive gate level structure 68a10 are positioned in an end-to-end spaced apart manner and are separated from each other by a second end-to-end spacing 68a43.As shown in FIG.", "68B, the first electrical connection 68a23 extends through a contact 68a35 that is connected to the second conductive gate level structure 68a04, and through a contact 68a37 that is connected to the fifth conductive gate level structure 68a10.As shown in FIG.", "68B, the second electrical connection 68a21 extends through a contact 68a33 that is connected to the third conductive gate level structure 68a06, through the seventh conductive gate level structure 68a14, and through a contact 68a39 that is connected to the fourth conductive gate level structure 68a08.FIG.", "68C shows an annotated version of FIG.", "68.The features depicted in FIG.", "68C are exactly the same as the features depicted in FIG.", "68.FIG.", "68C shows the first conductive gate level structure 68a02 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 68a45.FIG.", "68C shows each of the second conductive gate level structure 68a04 and third conductive gate level structure 68a06 to have their lengthwise centerlines substantially aligned with a gate electrode track 68a47.FIG.", "68C shows each of the third conductive gate level structure 68a08 and fourth conductive gate level structure 68a10 to have their lengthwise centerlines substantially aligned with a gate electrode track 68a49.FIG.", "68C shows the sixth conductive gate level structure 68a12 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 68a51.FIG.", "68C shows the seventh conductive gate level structure 68a14 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 68a53.As shown in FIG.", "68C, the gate electrodes of transistors 68a11 and 68a13 are separated by a centerline-to-centerline spacing 68a55.As shown in FIG.", "68C, the gate electrodes of transistors 68a13 and 68a15 are separated by a centerline-to-centerline spacing 68a57.As shown in FIG.", "68C, the gate electrodes of transistors 68a15 and 68a17 are separated by a centerline-to-centerline spacing 68a59.As shown in FIG.", "68C, the gate electrodes of transistors 68a17 and 68a19 are separated by a centerline-to-centerline spacing 68a61.As shown in FIG.", "68C, the gate electrodes of transistors 68a01 and 68a03 are separated by the centerline-to-centerline spacing 68a55.As shown in FIG.", "68C, the gate electrodes of transistors 68a03 and 68a05 are separated by the centerline-to-centerline spacing 68a57.As shown in FIG.", "68C, the gate electrodes of transistors 68a05 and 68a07 are separated by a centerline-to-centerline spacing 68a59.As shown in FIG.", "68C, the gate electrodes of transistors 68a07 and 68a09 are separated by a centerline-to-centerline spacing 68a61.As shown in FIG.", "68C, the centerline-to-centerline spacings 68a55, 68a57, 68a59, 68a61 are measured perpendicular to the parallel direction of the conductive gate level structures 68a02, 68a04, 68a06, 68a08, 68a10, 68a12, 68a14.As shown in FIG.", "68C, the contact 68a35 is located at a first position 68a65 in the parallel direction.", "As shown in FIG.", "68C, the contact 68a37 is located at a second position 68a63 in the parallel direction.", "FIG.", "109A shows an annotated version of FIG.", "109.The features depicted in FIG.", "109A are exactly the same as the features depicted in FIG.", "109.FIG.", "109A shows a first conductive gate level structure 109a02, a second conductive gate level structure 109a04, a third conductive gate level structure 109a06, a fourth conductive gate level structure 109a08, a fifth conductive gate level structure 109a10, a sixth conductive gate level structure 109a12, and a seventh conductive gate level structure 109a14, each extending lengthwise in a parallel direction.", "FIG.", "109A shows the first conductive gate level structure 109a02 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 109a09.FIG.", "109A shows the second conductive gate level structure 109a04 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 109a07.FIG.", "109A shows each of the third conductive gate level structure 109a06 and fourth conductive gate level structure 109a08 to have their lengthwise centerlines substantially aligned with a gate electrode track 109a05.FIG.", "109A shows the fifth conductive gate level structure 109a10 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 109a03.FIG.", "109A shows each of the sixth conductive gate level structure 109a12 and sixth conductive gate level structure 109a14 to have their lengthwise centerlines substantially aligned with a gate electrode track 109a01.As shown in FIG.", "109A, the gate electrode tracks 109a01, 109a03, 109a05, 109a07, and 109a09 are consecutively separated by gate pitches 109a11, 109a13, 109a15, and 109a17.As shown in FIG.", "109A, the gate pitches 109a11, 109a13, 109a15, and 109a17 are measured perpendicular to the parallel direction of the conductive gate level structures 109a02, 109a04, 109a06, 109a08, 109a10, 109a12, 109a14.As shown in FIG.", "109A, a first electrical connection 109a21 (as denoted by the heavy solid black line) electrically connects the third conductive gate level structure 109a06 to the seventh conductive gate level structure 109a14.As shown in FIG.", "109A, a second electrical connection 109a22 (as denoted by the heavy solid black line) electrically connects the sixth conductive gate level structure 109a12 to the fourth conductive gate level structure 109a08.As shown in FIG.", "109A, a third electrical connection 109a19 (as denoted by the heavy dashed black line) represents the common node electrical connection.", "FIG.", "109B shows an annotated version of FIG.", "109.The features depicted in FIG.", "109B are exactly the same as the features depicted in FIG.", "109.As shown in FIG.", "109B, the second conductive gate level structure 109a04 forms a gate electrode of a transistor 109a31 and a gate electrode of a transistor 109a23.As shown in FIG.", "109B, the third conductive gate level structure 109a06 forms a gate electrode of a transistor 109a33.As shown in FIG.", "109B, the fourth conductive gate level structure 109a08 forms a gate electrode of a transistor 109a25.As shown in FIG.", "109B, the fifth conductive gate level structure 109a10 forms a gate electrode of a transistor 109a35 and a gate electrode of a transistor 109a27.As shown in FIG.", "109B, the sixth conductive gate level structure 109a12 forms a gate electrode of a transistor 109a37.As shown in FIG.", "109B, the seventh conductive gate level structure 109a14 forms a gate electrode of a transistor 109a29.As shown in FIG.", "109B, the first electrical connection 109a21 extends through a contact 109a45 connected to the third conductive gate level structure 109a06, through the first conductive gate level structure 109a02, and through a contact 109a43 connected to the seventh conductive gate level structure 109a14.As shown in FIG.", "109B, the second electrical connection 109a22 extends through a contact 109a41 connected to the sixth conductive gate level structure 109a12, and through a contact 109a39 connected to the fourth conductive gate level structure 109a08.As shown in FIG.", "109B, the third conductive gate level structure 109a06 and the fourth conductive gate level structure 109a08 are positioned in an end-to-end spaced apart manner and are separated from each other by a first end-to-end spacing 109a49.As shown in FIG.", "109B, the sixth conductive gate level structure 109a12 and the seventh conductive gate level structure 109a14 are positioned in an end-to-end spaced apart manner and are separated from each other by a second end-to-end spacing 109a47.FIG.", "109C shows an annotated version of FIG.", "109.The features depicted in FIG.", "109C are exactly the same as the features depicted in FIG.", "109.FIG.", "109C shows an inner end position 109a55 of the third conductive gate level structure 109a06.FIG.", "109C shows an inner end position 109a57 of the fourth conductive gate level structure 109a08.FIG.", "109C shows an inner end position 109a51 of the sixth conductive gate level structure 109a12.FIG.", "109C shows an inner end position 109a53 of the seventh conductive gate level structure 109a14.FIG.", "111A shows an annotated version of FIG.", "111.The features depicted in FIG.", "111A are exactly the same as the features depicted in FIG.", "111.FIG.", "111A shows a first conductive gate level structure 111a02, a second conductive gate level structure 111a04, a third conductive gate level structure 111a06, a fourth conductive gate level structure 111a08, a fifth conductive gate level structure 111a10, a sixth conductive gate level structure 111a12, a seventh conductive gate level structure 111a14, and an eighth conductive gate level structure 111a16, each extending lengthwise in a parallel direction.", "FIG.", "111A shows the first conductive gate level structure 111a02 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 111a11.FIG.", "111A shows the second conductive gate level structure 111a04 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 111a09.FIG.", "111A shows the third conductive gate level structure 111a06 and the fourth conductive gate level structure 111a08 positioned to have their lengthwise centerlines substantially aligned with a gate electrode track 111a07.FIG.", "111A shows the fifth conductive gate level structure 111a10 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 111a05.FIG.", "111A shows the sixth conductive gate level structure 111a12 and the seventh conductive gate level structure 111a14 positioned to have their lengthwise centerlines substantially aligned with a gate electrode track 111a03.FIG.", "111A shows the eighth conductive gate level structure 111a16 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 111a01.As shown in FIG.", "111A, the gate electrode tracks 111a01, 111a03, 111a05, 111a07, 111a09, and 111a11 are consecutively separated by gate pitches 111a13, 111a15, 111a17, 111a19, and 111a21.As shown in FIG.", "109A, the gate pitches 111a13, 111a15, 111a17, 111a19, and 111a21 are measured perpendicular to the parallel direction of the conductive gate level structures 111a02, 111a04, 111a06, 111a08, 111a10, 111a12, 111a14, 111a16.As shown in FIG.", "111A, the first conductive gate level structure 111a02 forms a gate electrode of a transistor 111a41 and a gate electrode of a transistor 111a31.As shown in FIG.", "111A, the second conductive gate level structure 111a04 forms a gate electrode of a transistor 111a39 and a gate electrode of a transistor 111a29.As shown in FIG.", "111A, the third conductive gate level structure 111a06 forms a gate electrode of a transistor 111a37.As shown in FIG.", "111A, the fourth conductive gate level structure 111a08 forms a gate electrode of a transistor 111a27.As shown in FIG.", "111A, the fifth conductive gate level structure 111a10 forms a gate electrode of a transistor 111a35 and a gate electrode of a transistor 111a25.As shown in FIG.", "111A, the sixth conductive gate level structure 111a12 forms a gate electrode of a transistor 111a33.As shown in FIG.", "111A, the seventh conductive gate level structure 111a14 forms a gate electrode of a transistor 111a23.As shown in FIG.", "111A, a first electrical connection 111a45 (as denoted by the heavy solid black line) electrically connects the sixth conductive gate level structure 111a12 to the fourth conductive gate level structure 111a08.As shown in FIG.", "111A, a second electrical connection 111a47 (as denoted by the heavy solid black line) electrically connects the third conductive gate level structure 111a06 to the seventh conductive gate level structure 111a14.As shown in FIG.", "111A, the second electrical connection extends through the eighth conductive gate level feature 111a49.As shown in FIG.", "111A, a third electrical connection 111a43 (as denoted by the heavy dashed black line) represents the common node electrical connection.", "FIG.", "111B shows an annotated version of FIG.", "111.The features depicted in FIG.", "111B are exactly the same as the features depicted in FIG.", "111.As shown in FIG.", "111B, the first electrical connection 111a45 extends through gate contact 111a57 connected to the sixth conductive gate level structure 111a12, and through the gate contact 111a59 connected to the fourth conductive gate level structure 111a08.As shown in FIG.", "111B, the first electrical connection 111a45 extends through a linear-shaped conductive interconnect structure 111a51 in a single interconnect level.", "As shown in FIG.", "111B, the second electrical connection 111a47 extends through gate contact 111a55 connected to the third conductive gate level structure 111a06, and through the gate contact 111a53 connected to the seventh conductive gate level structure 111a14.FIGS.", "112-148 show a number of exemplary cross-coupled transistor layouts in which the p-type diffusion regions that are electrically interfaced with the cross-coupled transistors are physically separated from each other.", "For example, with regard to FIG.", "112, the p-type diffusion region 8601p is physically separated from the p-type diffusion region 8603p.", "However, the p-type diffusion regions 8601p and 8603p are electrically connected to each other by way of contact 8605p, metal 1 interconnect level feature 8607p, and contact 8609p.", "Although not shown, the diffusion regions 8601p and 8603p are also electrically connected to diffusion region 8611p.", "It should be understood that a variant of each cross-coupled transistor layout as shown in each of FIGS.", "112-148, can be defined by changing the p-type diffusion regions as shown to n-type diffusion regions, and by also changing the n-type diffusion regions as shown to p-type diffusions regions.", "Therefore, such variants of FIGS.", "112-148 illustrate a number of exemplary cross-coupled transistor layouts in which the n-type diffusion regions that are electrically interfaced with the cross-coupled transistors are physically separated from each other.", "FIGS.", "149-175 show a number of exemplary cross-coupled transistor layouts defined using two gate contacts to connect one pair of complementary (i.e., NMOS/PMOS) transistors in the cross-coupled transistor layout to each other, and using no gate contact to connect the other pair of complementary transistors in the cross-coupled transistor layout to each other.", "It should be understood that two gate electrodes of each pair of cross-coupled transistors, when considered as a single node, are electrically connected through at least one gate contact to circuitry external to the cross-coupled transistor portion of the layout.", "Therefore, it should be understood that the gate electrodes mentioned above, or absence thereof, with regard to connecting each pair of complementary transistors in the cross-coupled transistor layout, refer to gate electrodes defined within the cross-coupled transistor portion of the layout.", "For example, FIG.", "149 shows a cross-coupled transistor layout in which a gate electrode of transistor 12301p is electrically connected to a gate electrode of transistor 12303p by way of two gate contacts 12309p and 12311p in combination with other conductive features.", "Also, the gate electrodes of transistors 12305p and 12307p are defined as a single, continuous linear conductive feature within the gate level.", "Therefore, a gate contact is not required to electrically connect the gate electrodes of transistors 12305p and 12307p.", "The conductive path used to connect the diffusion regions of the cross-coupled transistors to the common output node in each of FIGS.", "149-175 is identified by a heavy black dashed line drawn over the corresponding layout features.", "It should be appreciated that the cross-coupled transistor layout defined using two gate contacts to connect one pair of complementary transistors and no gate contact to connect the other pair of complementary transistors can be implemented in as few as two gate electrode tracks, wherein a gate electrode track is defined as a virtual line extending across the gate level in a parallel relationship to its neighboring gate electrode tracks.", "These two gate electrode tracks can be located essentially anywhere in the layout with regard to each other.", "In other words, these two gate electrode tracks are not required to be located adjacent to each other, although such an arrangement is permitted, and in some embodiments may be desirable.", "The cross-coupled transistor layout embodiments of FIGS.", "149-175 can be characterized in that two gate electrodes of one pair of connected complementary transistors in the cross-coupled layout are defined from a single, continuous linear conductive feature defined in the gate level.", "FIG.", "156A shows an annotated version of FIG.", "156.The features depicted in FIG.", "156A are exactly the same as the features depicted in FIG.", "156.FIG.", "156A shows a first conductive gate level structure 156a02 that forms a gate electrode of a transistor 156a21.FIG.", "156A shows a second conductive gate level structure 156a04 that forms a gate electrode of a transistor 156a19 and a gate electrode of a transistor 156a11.FIG.", "156A shows a third conductive gate level structure 156a06 that forms a gate electrode of a transistor 156a13.FIG.", "156A shows a fourth conductive gate level structure 156a08 that forms a gate electrode of a transistor 156a23 and a gate electrode of a transistor 156a15.FIG.", "156A shows a fifth conductive gate level structure 156a10 that forms a gate electrode of a transistor 156a25 and a gate electrode of a transistor 156a17.As shown in FIG.", "156A, each conductive gate level feature 156a02, 156a04, 156a06, 156a08, 156a10 extends lengthwise in a parallel direction.", "FIG.", "156A shows the first conductive gate level structure 156a02 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 156a01.FIG.", "156A shows the second conductive gate level structure 156a04 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 156a03.FIG.", "156A shows the third conductive gate level structure 156a06 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 156a05.As shown in FIG.", "156A, the first and second gate electrode tracks 156a01 and 156a03 are separated by a gate pitch 156a07.As shown in FIG.", "156A, the second and third gate electrode tracks 156a03 and 156a05 are separated by a gate pitch 156a09.As shown in FIG.", "156A, a first electrical connection 156a26 (as denoted by the heavy solid line) extends from the transistor 156a19 to the transistor 156a11, through the second conductive gate level structure 156a04.As shown in FIG.", "156A, a second electrical connection 156a27 (as denoted by the heavy solid line) extends from the transistor 156a21 to the transistor 156a13.As shown in FIG.", "156A, a third electrical connection 156a29 (as denoted by the heavy dashed line) shows the common node electrical connection.", "FIG.", "156B shows an annotated version of FIG.", "156.The features depicted in FIG.", "156B are exactly the same as the features depicted in FIG.", "156.As shown in FIG.", "156B, the second electrical connection 156a27 extend through gate contact 156a53 and through gate contact 156a51.As shown in FIG.", "156B, the gate contact 156a53 is located at a contact position 156a35.As shown in FIG.", "156B, the gate contact 156a51 is located at a contact position 156a37.As shown in FIG.", "156B, the second conductive gate level structure 156a04 is connected to gate contact 156a55, which is located at a contact position 156a39.As shown in FIG.", "156B, each of the first conductive gate level structure 156a02 and the third conductive gate level structure 156a06 has a respective end aligned to a common position 156a33 in the parallel direction.", "FIG.", "157A shows an annotated version of FIG.", "157.The features depicted in FIG.", "157A are exactly the same as the features depicted in FIG.", "157.FIG.", "157A shows a first conductive gate level structure 157a02, a second conductive gate level structure 157a04, a third conductive gate level structure 157a06, a fourth conductive gate level structure 157a08, a fifth conductive gate level structure 157a10, and a sixth conductive gate level structure 157a12, each extending lengthwise in a parallel direction.", "FIG.", "157A shows the first conductive gate level structure 157a02 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 157a01.FIG.", "157A shows the second conductive gate level structure 157a04 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 157a03.FIG.", "157A shows the third conductive gate level structure 157a06 and the fourth conductive gate level structure 157a08 positioned to have their lengthwise centerlines substantially aligned with a gate electrode track 157a05.FIG.", "157A shows the fifth conductive gate level structure 157a010 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 157a07.FIG.", "157A shows the sixth conductive gate level structure 157a12 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 157a09.As shown in FIG.", "157A, the gate electrode tracks 157a01, 157a03, 157a05, 157a07, and 157a09, are consecutively separated by gate pitches 157a11, 157a13, 157a15, and 157a17.As shown in FIG.", "109A, the gate pitches 157a11, 157a13, 157a15, and 157a17 are measured perpendicular to the parallel direction of the conductive gate level structures 157a02, 157a04, 157a06, 157a08, 157a10, 157a12.As shown in FIG.", "157A, the first conductive gate level structure 157a02 forms a gate electrode of a transistor 157a29.As shown in FIG.", "157A, the second conductive gate level structure 157a04 forms a gate electrode of a transistor 157a27 and a gate electrode of a transistor 157a19.As shown in FIG.", "157A, the third conductive gate level structure 157a06 forms a gate electrode of a transistor 157a31.As shown in FIG.", "157A, the fourth conductive gate level structure 157a08 forms a gate electrode of a transistor 157a21.As shown in FIG.", "157A, the fifth conductive gate level structure 157a10 forms a gate electrode of a transistor 157a23.As shown in FIG.", "157A, the sixth conductive gate level structure 157a12 forms a gate electrode of a transistor 157a33 and a gate electrode of a transistor 157a25.As shown in FIG.", "157A, a first electrical connection 157a50 (as denoted by the heavy solid line) extends from the transistor 157a27 to the transistor 157a51, through the second conductive gate level structure 157a04.As shown in FIG.", "157A, a second electrical connection 157a51 (as denoted by the heavy solid line) extends from the transistor 157a29 to the transistor 157a21.As shown in FIG.", "157A, a third electrical connection 157a53 (as denoted by the heavy dashed line) shows the common node electrical connection.", "FIG.", "157B shows an annotated version of FIG.", "157.The features depicted in FIG.", "157B are exactly the same as the features depicted in FIG.", "157.As shown in FIG.", "157B, the second electrical connection 157a51 extends through gate contact 157a41 and through gate contact 157a39.As shown in FIG.", "157B, the gate contact 157a41 is located at a contact position 157a47.As shown in FIG.", "157B, the gate contact 157a39 is located at a contact position 157a45.As shown in FIG.", "157B, the second conductive gate level structure 157a50 is connected to gate contact 157a43, which is located at a contact position 157a49.As shown in FIG.", "157B, each of the first conductive gate level structure 157a02 and the fourth conductive gate level structure 157a08 has a respective end aligned to a common position 157a37 in the parallel direction.", "As shown in FIG.", "157B, the fifth conductive gate level structure 157a10 forms the gate electrode of the transistor 157a23 with the Pdiff regions and extends between and spaced apart from two Ndiff regions 157a69 and 157a67.FIG.", "170A shows an annotated version of FIG.", "170.The features depicted in FIG.", "170A are exactly the same as the features depicted in FIG.", "170.FIG.", "170A shows a first conductive gate level structure 170a02, a second conductive gate level structure 170a04, a third conductive gate level structure 170a06, a fourth conductive gate level structure 170a08, a fifth conductive gate level structure 170a10, and a sixth conductive gate level structure 170a12, each extending lengthwise in a parallel direction.", "FIG.", "170A shows the first conductive gate level structure 170a02 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 170a01.FIG.", "170A shows the second conductive gate level structure 170a04 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 170a03.FIG.", "170A shows the third conductive gate level structure 170a06 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 170a05.FIG.", "170A shows the fourth conductive gate level structure 170a08 and the fifth conductive gate level structure 170a10 positioned to have their lengthwise centerlines substantially aligned with a gate electrode track 170a07.FIG.", "170A shows the sixth conductive gate level structure 170a12 positioned to have its lengthwise centerline substantially aligned with a gate electrode track 170a09.As shown in FIG.", "170A, the gate electrode tracks 170a01, 170a03, 170a05, 170a07, and 170a09, are consecutively separated by gate pitches 170a11, 170a13, 170a15, and 170a17.As shown in FIG.", "170A, the gate pitches 170a11, 170a13, 170a15, and 170a17 are measured perpendicular to the parallel direction of the conductive gate level structures 170a02, 170a04, 170a06, 170a08, 170a10, 170a12.As shown in FIG.", "170A, the first conductive gate level structure 170a02 forms a gate electrode of a transistor 170a33 and a gate electrode of a transistor 170a25.As shown in FIG.", "170A, the second conductive gate level structure 170a04 forms a gate electrode of a transistor 170a29.As shown in FIG.", "170A, the third conductive gate level structure 170a06 forms a gate electrode of a transistor 170a27 and a gate electrode of a transistor 170a19.As shown in FIG.", "170A, the fourth conductive gate level structure 170a08 forms a gate electrode of a transistor 170a31.As shown in FIG.", "170A, the fifth conductive gate level structure 170a10 forms a gate electrode of a transistor 170a21.As shown in FIG.", "170A, the sixth conductive gate level structure 170a12 forms a gate electrode of a transistor 170a23.As shown in FIG.", "170A, a first electrical connection 170a60 (as denoted by the heavy solid line) extends from the transistor 170a27 to the transistor 170a19, through the third conductive gate level structure 170a06.As shown in FIG.", "170A, a second electrical connection 170a61 (as denoted by the heavy solid line) extends from the transistor 170a29 to the transistor 170a21.As shown in FIG.", "170A, a third electrical connection 170a63 (as denoted by the heavy dashed line) shows the common node electrical connection.", "FIG.", "170B shows an annotated version of FIG.", "170.The features depicted in FIG.", "170B are exactly the same as the features depicted in FIG.", "170.As shown in FIG.", "170B, the second electrical connection 170a61 extends through gate contact 170a39 and through gate contact 170a37.As shown in FIG.", "170B, the gate contact 170a39 is located at a contact position 170a45.As shown in FIG.", "170B, the gate contact 170a37 is located at a contact position 170a43.As shown in FIG.", "170B, the third conductive gate level structure 170a06 is connected to gate contact 170a41, which is located at a contact position 170a47.As shown in FIG.", "170B, each of the first conductive gate level structure 170a02, the third conductive gate level structure 170a06, and the fifth conductive gate level structure 170a10 has a respective end aligned to a common position 170a35 in the parallel direction.", "As shown in FIG.", "170B, the sixth conductive gate level structure 170a12 forms the gate electrode of the transistor 170a23 with the Pdiff regions and includes a portion 170a12a that extends next to and spaced apart from an Ndiff region.", "FIGS.", "176-191 show a number of exemplary cross-coupled transistor layouts defined using no gate contacts to connect each pair of complementary transistors in the cross-coupled transistor layout.", "Again, it should be understood that two gate electrodes of each pair of cross-coupled transistors, when considered as a single node, are electrically connected through at least one gate contact to circuitry external to the cross-coupled transistor portion of the layout.", "Therefore, it should be understood that the absence of gate electrodes with regard to connecting each pair of complementary transistors in the cross-coupled transistor layout refers to an absence of gate electrodes defined within the cross-coupled transistor portion of the layout.", "For example, FIG.", "176 shows a cross-coupled transistor layout in which gate electrodes of transistors 15001p and 15003p are defined as a single, continuous linear conductive feature within the gate level.", "Therefore, a gate contact is not required to electrically connect the gate electrodes of transistors 15001p and 15003p.", "Also, gate electrodes of transistors 15005p and 15007p are defined as a single, continuous linear conductive feature within the gate level.", "Therefore, a gate contact is not required to electrically connect the gate electrodes of transistors 15005p and 15007p.", "The conductive path used to connect the diffusion regions of the cross-coupled transistors to the common output node in each of FIGS.", "176-191 is identified by a heavy black dashed line drawn over the corresponding layout features.", "It should be appreciated that the cross-coupled transistor layout defined using no gate contact to connect each pair of complementary transistors can be implemented in as few as one gate electrode track.", "The cross-coupled transistor layout embodiments of FIGS.", "176-191 can be characterized in that each pair of connected complementary transistors in the cross-coupled layout has its gate electrodes defined from a single, continuous linear conductive feature defined in the gate level.", "FIG.", "192 shows another exemplary cross-couple transistor layout in which the common diffusion node shared between the cross-coupled transistors 16601p, 16603p, 16605p, and 16607p has one or more transistors defined thereover.", "Specifically, FIG.", "192 shows that transistors 16609Ap and 16609Bp are defined over the diffusion region 16613p between transistors 16605p and 16603p.", "Also, FIG.", "192 shows that transistors 16611Ap and 16611Bp are defined over the diffusion region 16615p between transistors 16601p and 16607p.", "It should be understood that diffusion regions 16613p and 16615p define the common diffusion node to which each of the cross-coupled transistors 16601p, 16603p, 16605p, and 16607p is electrically interfaced.", "It should be appreciated that with this type of cross-coupled transistor layout, driver transistors, such as transistors 16609Ap, 16609Bp, 16611Ap, and 16611Bp, can be disposed over the common diffusion node of the cross-coupled transistors.", "Hence, the cross-coupled transistors can be considered as being placed “outside” of the driver transistors.", "As illustrated in FIGS.", "26-192, the cross-coupled transistor layout using a linear gate level can be defined in a number of different ways.", "A number of observations associated with the cross-coupled transistor layout defined using the linear gate level are as follows: In one embodiment, an interconnect level parallel to the gate level is used to connect the two “outside” transistors, i.e., to connect the two outer gate contacts.", "In one embodiment, the end gaps, i.e., line end spacings, between co-aligned gate electrode features in the area between the n and p diffusion regions can be substantially vertically aligned to enable line end cutting.", "In one embodiment, the end gaps, i.e., line end spacings, between gate electrode features in the area between the n and p diffusion regions can be separated as much as possible to allow for separation of cut shapes, or to prevent alignment of gate electrode feature line ends.", "In one embodiment, the interconnect levels can be configured so that contacts can be placed on a grid to enhance contact printing.", "In one embodiment, the contacts can be placed so that a minimal number of first interconnect level (Metal-1 level) tracks are occupied by the cross-couple connection.", "In one embodiment, the contacts can be placed to maximize the available diffusion area for device size, e.g., transistor width.", "In one embodiment, the contacts can be shifted toward the edges of the interconnect level features to which they connect to allow for better alignment of gate electrode feature line ends.", "In pertinent embodiments, it should be noted that the vertical connection between the outside transistors of the cross-coupled transistor layout can be shifted left or right depending on the specific layout requirements.", "There is no distance requirement between the n and p diffusion regions.", "If there are more interconnect level tracks available between the n and p diffusion region, the available interconnect level tracks can be allocated as necessary/appropriate for the layout.", "The four transistors of the cross-coupled transistor configuration, as defined in accordance with the linear gate level, can be separated from each other within the layout by arbitrary distances in various embodiments.", "In one embodiment, the linear gate electrode features are placed according to a virtual grid or virtual grate.", "However, it should be understood that in other embodiments the linear gate electrode features, although oriented to have a common direction of extent, are placed without regard to a virtual grid or virtual grate.", "Each linear gate electrode feature is allowed to have one or more contact head portion(s) along its line of extent, so long as the linear gate electrode feature does not connect directly within the gate level to another linear gate electrode feature having a different, yet parallel, line of extent.", "Diffusion regions associated with the cross-coupled transistor configuration, as defined in accordance with the linear gate level, are not restricted in size or shape.", "The four transistors of the cross-coupled transistor configuration, as defined in accordance with the linear gate level, may vary in size as required to satisfy electrical requirements.", "Essentially any cross-coupled transistor configuration layout defined in accordance with a linear gate level can be represented in an alternate manner by horizontally and/or vertically reversing placement of the gate contacts that are used to connect one or both pairs of the four transistors of the cross-coupled transistor configuration.", "Essentially any cross-coupled transistor configuration layout defined in accordance with a linear gate level can be represented in an alternate manner by maintaining gate contact placements and by modifying each routing path used to connect one or both pairs of the four transistors of the cross-coupled transistor configuration.", "A cross-coupled transistor configuration layout defined in accordance with a linear gate level can be optimized for a fabrication process that utilizes a cut mask.", "In various embodiments, connections between gates of cross-coupled transistors can be made in essentially any manner by utilizing any level within the chip, any number of levels in the chip, any number of contacts, and/or any number of vias.", "It should be appreciated that in the embodiments of FIGS.", "26-192, a number of features and connections are not shown in order to avoid unnecessarily obscuring the cross-couple transistors in the various layouts.", "For example, in the embodiments of FIGS.", "26-60, connections to source and drains are not shown.", "Also, it should be understood that in the exemplary embodiments of FIGS.", "26-192, some features and connections that are not directly associated with the four cross-coupled transistors are displayed for exemplary purposes and are not intended to represent any restriction on the correspondingly displayed cross-coupled transistor layout.", "Based on the foregoing, a cross-coupled transistor layout using commonly oriented linear gate level features and transistors having physically separate gate electrodes can be defined according to either of the following embodiments, among others: all four gate contacts used to connect each pair of complementary transistors in the cross-coupled transistor layout are placed between the diffusion regions associated with the cross-coupled transistor layout, two gate contacts used to connect one pair of complementary transistors placed between the diffusion regions associated with the cross-coupled transistor layout, and two gate contacts used to connect another pair of complementary transistors placed outside the diffusion regions with one of these two gate contacts placed outside of each diffusion region, all four gate contacts used to connect each pair of complementary transistors placed outside the diffusion regions associated with the cross-coupled transistor layout, three gate contacts placed outside the diffusion regions associated with the cross-coupled transistor layout, and one gate contact placed between the diffusion regions associated with the cross-coupled transistor layout, and three gate contacts placed between the diffusion regions associated with the cross-coupled transistor layout, and one gate contact placed outside one of the diffusion regions associated with the cross-coupled transistor layout.", "It should be understood that the cross-coupled transistor layouts implemented within the restricted gate level layout architecture as disclosed herein can be stored in a tangible form, such as in a digital format on a computer readable medium.", "Also, the invention described herein can be embodied as computer readable code on a computer readable medium.", "The computer readable medium is any data storage device that can store data which can thereafter be read by a computer system.", "Examples of the computer readable medium include hard drives, network attached storage (NAS), read-only memory, random-access memory, CD-ROMs, CD-Rs, CD-RWs, magnetic tapes, and other optical and non-optical data storage devices.", "The computer readable medium can also be distributed over a network of coupled computer systems so that the computer readable code is stored and executed in a distributed fashion.", "Any of the operations described herein that form part of the invention are useful machine operations.", "The invention also relates to a device or an apparatus for performing these operations.", "The apparatus may be specially constructed for the required purpose, such as a special purpose computer.", "When defined as a special purpose computer, the computer can also perform other processing, program execution or routines that are not part of the special purpose, while still being capable of operating for the special purpose.", "Alternatively, the operations may be processed by a general purpose computer selectively activated or configured by one or more computer programs stored in the computer memory, cache, or obtained over a network.", "When data is obtained over a network the data maybe processed by other computers on the network, e.g., a cloud of computing resources.", "The embodiments of the present invention can also be defined as a machine that transforms data from one state to another state.", "The data may represent an article, that can be represented as an electronic signal and electronically manipulate data.", "The transformed data can, in some cases, be visually depicted on a display, representing the physical object that results from the transformation of data.", "The transformed data can be saved to storage generally, or in particular formats that enable the construction or depiction of a physical and tangible object.", "In some embodiments, the manipulation can be performed by a processor.", "In such an example, the processor thus transforms the data from one thing to another.", "Still further, the methods can be processed by one or more machines or processors that can be connected over a network.", "Each machine can transform data from one state or thing to another, and can also process data, save data to storage, transmit data over a network, display the result, or communicate the result to another machine.", "While this invention has been described in terms of several embodiments, it will be appreciated that those skilled in the art upon reading the preceding specifications and studying the drawings will realize various alterations, additions, permutations and equivalents thereof.", "Therefore, it is intended that the present invention includes all such alterations, additions, permutations, and equivalents as fall within the true spirit and scope of the invention." ] ]
Patent_15872893
[ [ "CONCEALED CARRY CLIP FOR HANDGUNS", "The present invention provides an improved concealed carry clip, that attaches with machine screws to the slide rear cover plate, and which has friction features on the clip to facilitate drawing back the slide with the thumb and index finger.", "In addition, the cover plate can be equipped with projections that reduce shearing forces on the machine screws.", "As with the Clipdraw product, a drilled and tapped replacement rear cover plate is provided with the improved concealed carry clip.", "Though the improved concealed carry clips have, to date, been designed for Clock®, M&P® and Springfield Armory® XD handguns, the concealed carry clips may be adapted for use on other similarly constructed handguns in the future." ], [ "1.A handgun clip, comprising: a clip, including a mounting tab which is connectable to a rear slide cover plate of a handgun, the clip extending along a slide of the handgun with a forward end of the clip terminating before a chamber of the handgun and including one or more through hole punchings along the clip or one or more stamped protrusions along the clip.", "2.The handgun clip of claim 1, wherein the mounting tab includes one or more apertures through which the clip is connectable to the rear slide cover plate of the handgun.", "3.The handgun clip of claim 1, wherein the mounting tab of the clip is disposed at a right angle to the clip.", "4.The handgun clip of claim 1, wherein the forward end of the clip contacts the slide of the handgun at a point before the chamber of the handgun.", "5.The handgun clip of claim 4, wherein the forward end of the clip is separated from the mounting tab portion of the clip by a clip portion of the clip.", "6.The handgun clip of claim 5, wherein the clip portion of the clip does not physically contact the slide of the handgun.", "7.The handgun clip of claim 1, wherein the clip includes both in-relief punchings and stamped protrusions.", "8.The handgun clip of claim 1, wherein the one or more stamped protrusions are disposed on the clip between the mounting tab and the forward end of the clip.", "9.The handgun clip of claim 1, wherein the one or more through-hole in relief punchings are disposed on the clip between the mounting tab and the forward end of the clip.", "10.The handgun clip of claim 1, wherein there are between three and four stamped protrusions disposed on the clip between the mounting tab and the forward end of the clip.", "11.The handgun clip of claim 1, wherein there are between three and four through-hole in relief punchings disposed on the clip between the mounting tab and the forward end of the clip.", "12.The handgun clip of claim 1, wherein the forward end of the clip comes into contact with the slide of the handgun and is thereafter bent in a direction away from the slide of the handgun.", "13.The handgun clip of claim 1, wherein the forward end of the clip terminates at a pivot pin of an ejector along the slide of the handgun.", "14.A system, comprising: a rear slide cover plate of a handgun, and a clip, including a mounting tab which connects to the rear slide cover plate of a handgun, the clip extending along a slide of the handgun with a forward end of the clip terminating before a chamber of the handgun and including one or more through hole punchings along the clip or one or more stamped protrusions along the clip.", "15.The system of claim 14, wherein the forward end of the clip contacts the slide of the handgun at a point before the chamber of the handgun.", "16.The system of claim 15, wherein the forward end of the clip is separated from the mounting tab portion of the clip by a clip portion of the clip.", "17.The system of claim 16, wherein the clip portion of the clip does not physically contact the slide of the handgun.", "18.The system of claim 14, wherein the mounting tab includes two apertures corresponding to two apertures in the rear slide cover plate of the handgun.", "19.The system of claim 18, wherein the mounting tab is connected to the rear slide cover plate of the handgun by two screws which are each disposed through one of two apertures included in the mounting tab and into one of the two apertures in the rear slide cover plate of the handgun.", "20.The system of claim 14, wherein the mounting tab is connected to the rear slide cover plate between an upper projection on the rear slide cover plate and a lower projection on the rear slide cover plate." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>" ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present invention provides an improved concealed carry clip, that attaches with screws to the slide rear cover plate, and which has through-hole friction punchings or stamped protrusions on the clip to facilitate drawing back the slide with the thumb and index finger.", "In addition, the mounting tab of the clip may fit against one or between two projections that are machined into the rear cover plate.", "The projections not only reduce shear loads on the machine screws that secure the clip to the rear cover plate, but also prevent the clip from rocking on the securing machine screws.", "As with the Clipdraw product, a drilled and tapped replacement rear cover plate is provided with the improved concealed carry clip.", "Though the improved concealed carry clips have, to date, been designed for Clock®, M&P® and Springfield Armory® XD handguns, the concealed carry clips may be adapted for use on other similarly constructed handguns." ], [ "BACKGROUND OF THE INVENTION 1.Field of the Invention This invention relates to the field of firearms, and to handguns in particular.", "The invention provides a clip which can be used to carry the gun, and which is removable and repositionable so as to allow the clip to be used on a plurality of different guns.", "2.History of the Prior Art There are many circumstances in which there is a legitimate need to carry a concealed weapon.", "For example, plain-clothes law enforcement officers need to carry firearms in an inconspicuous manner.", "Also, off-duty officers may need the same capability.", "But the same person who needs to conceal the weapon at certain times may also want to keep the weapon in a holster at other times, when concealment is not required.", "Most modern semi-automatic handguns share common design parameters.", "FIG.", "1 shows a right side view of a handgun 100 manufactured by the Springfield Armory.", "This model is the XD-S. Like other modern handguns, it has a composite frame 101, which incorporates a hollow handle 102 which receives a multi-cartridge clip 103, and a trigger assembly 104.A slide 105, which moves backward in reaction to each firing, enables the semi-automatic operation.", "The slide 105 incorporates a barrel 106, a chamber 107, and an ejector 108 which strips spent cartridges and ejects them from the chamber 107.The ejector 108, which pivots on roll pin 109, swings outwardly as spent cartridges are ejected.", "It has been known to attach a clip to a handgun, so as to allow the handgun to be carried near the user's waist, with the clip engaging the user's belt or pants waistband.", "One example of such a clip is shown in U.S. Pat.", "No.", "6,155,468 to Francis L. Kinnich.", "A concealed carry clip is disclosed for a semiautomatic pistol, such as a 0.45 caliber.", "The clip is attached to the slide stop of the weapon.", "Size and weight of the clip is minimized so that its effect on the bulk, weight or balance of the weapon is negligible.", "The clip may be rounded to avoid digging into material it is clipped over.", "The interior surface may be flat or rounded to provide a snug fit.", "Another product, sold under the Clipdraw™ brand, and available from Skyline Toolworks LLC, of Malvern, Pa., provides a belt clip for carrying a handgun.", "The one-piece clip is screwed directly onto the handgun when it is desired to clip the gun to a belt, or removed therefrom when it is desired to carry the handgun in a holster.", "A problem with the Clipdraw product described above is that the clip is attached to the handgun with either existing screw holes or new screw holes that are drilled and tapped into the handgun.", "Few gun owners are willing to drill into the body of a valued handgun.", "Clipdraw also provides another type of concealed carry clip that attaches to the rear cover plate of the slide.", "A drilled and tapped replacement rear cover plate is provided with the clip.", "After swapping the original rear cover plate for the drilled and tapped replacement cover plate, the clip is screwed to the replacement cover plate.", "For Clock handguns, a billet drilled and tapped aluminum cover is provided to replace the original composite plastic cover plate.", "An advantage to this arrangement is that the handgun can be returned to stock condition by substituting the original cover plate for the drilled and tapped replacement cover plate.", "A disadvantage to this particular Clipdraw product is that it partially covers the right side of the slide so that the machined or molded friction slots at the right rear of the slide—which assist in pulling the slide back with the thumb and index finger—are covered with the clip, which has no friction grooves.", "Another problem with the design of the clip is that the machine screws that secure the clip to the replacement cover plate may be subjected to shearing forces that can cause the screws to structurally fail.", "SUMMARY OF THE INVENTION The present invention provides an improved concealed carry clip, that attaches with screws to the slide rear cover plate, and which has through-hole friction punchings or stamped protrusions on the clip to facilitate drawing back the slide with the thumb and index finger.", "In addition, the mounting tab of the clip may fit against one or between two projections that are machined into the rear cover plate.", "The projections not only reduce shear loads on the machine screws that secure the clip to the rear cover plate, but also prevent the clip from rocking on the securing machine screws.", "As with the Clipdraw product, a drilled and tapped replacement rear cover plate is provided with the improved concealed carry clip.", "Though the improved concealed carry clips have, to date, been designed for Clock®, M&P® and Springfield Armory® XD handguns, the concealed carry clips may be adapted for use on other similarly constructed handguns.", "BRIEF DESCRIPTION OF THE DRAWINGS FIG.", "1 is a side elevational view of a Springfield Armory XD-S handgun; FIG.", "2 is a perspective view of the slide of a Glock handgun that has been fitted with a drilled and tapped replacement rear cover plate, with the improved concealed carry clip ready to be secured thereto with a pair of machine screws; FIG.", "3 is an isometric view of a drilled and tapped replacement rear cover plate for the slide of a Glock handgun; FIG.", "4 is an isometric view of an improved concealed carry clip for a Glock handgun; FIG.", "5 is an isometric view of a drilled and tapped replacement rear cover plate for the slide of an M&P handgun; FIG.", "6 is an isometric view of an improved concealed carry clip for an M&P handgun; FIG.", "7 is an isometric view of a drilled and tapped replacement rear cover plate for the slide of an XD handgun; FIG.", "8 is an isometric view of an improved concealed carry clip for an XD handgun; FIG.", "9 is an isometric view of a drilled and tapped replacement rear cover plate for the slide of a Glock 42 handgun; FIG.", "10 is an isometric view of an improved concealed carry clip for a Glock 42 handgun; FIG.", "11 is an isometric view of a drilled and tapped replacement rear cover plate for the slide of an XD-S handgun; FIG.", "12 is an isometric view of an improved concealed carry clip for an XD-S handgun; FIG.", "13 is an alternative isometric view of the improved concealed carry clip for an XD-S handgun; FIG.", "14 is a side elevational view of an XD-S handgun with the rear cover plate of FIG.", "11 and the concealed carry clip of FIGS.", "12 and 13 installed thereon; FIG.", "15 is a side elevational view of an XD-S handgun with the rear cover plate of FIG.", "11 and a shortened version of the concealed carry clip of FIGS.", "12 and 13 installed thereon.", "DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT The invention will now be described with reference to the attached drawing figures.", "It should be understood that the drawings are not necessarily drawn to scale and are intended to be merely illustrative of the invention.", "The present invention provides an improved concealed carry clip, that attaches with screws to the slide rear cover plate, and which has friction punching on the clip to facilitate drawing back the slide with the thumb and index finger.", "As with the Clipdraw product, a drilled and tapped replacement rear cover plate is provided with the improved concealed carry clip.", "Certain improvements have been made which distinguish the concealed carry clips of the present invention from those marketed by Clipdraw.", "Most notably, the clips are equipped with friction enhancing punching or protrusions that facilitate drawing back the slide of the handgun with the thumb and index finger.", "In addition, certain rear cover plates are equipped with projections that shearing loads on the connecting screws are either completely eliminated or significantly reduced.", "Referring now to FIG.", "2, the slide 201 of a Glock 17, 19, 22, 23, 24, 25, 26, 27, 28, 30-S, 31, 32, 33, 34, 35 or 36 handgun has been removed from the receiver, and the original composite rear cover plate has been replaced with an aluminum rear cover plate 202 that has been equipped with threaded screw holes 203L and 203R.", "The improved concealed carry clip 200 is ready to be secured to the aluminum rear cover plate 102 with a pair of machine screws 105L and 105R.", "Referring now to FIG.", "3, the replacement aluminum rear cover plate 202 for a Glock 17, 19, 22, 23, 24, 25, 26, 27, 28, 30-S, 31, 32, 33, 34, 35 or 36 handgun is shown in greater detail.", "The cover plate 202 has been equipped with threaded screw holes 203L and 203R.", "It will be noted that the cover plate 202 is further equipped with an upper projection 301 and a lower projection 302.Referring now to FIG.", "4, the improved concealed carry clip 200 for a Glock handgun is shown in greater detail.", "It will be noted that the concealed carry clip 200 has a mounting tab 401 equipped with two apertures 302L and 302R, by means of which the clip 200 will be attached with machine screws to the replacement aluminum rear cover plate 202.The mounting tab 401 fits snugly between the upper projection 301 and the lower projection 302 of the cover plate 202 so that shearing loads on the securing screws 205L and 205R are eliminated.", "In addition, the projections also prevent the mounting tab 401 from rocking on the securing machine screws when there is not a tight fit between the apertures 402L and 402R and the screws 205L and 205R, respectively.", "The rocking motion of the mounting tab 401 on the securing screws 205L and 205R can also be minimized by using shoulder screws so that the screw shoulders, and not threads, are in contact with the apertures 402L and 402R.", "As threads have very little surface area, the clearance between the threads of the screws near the head tends to increase with use.", "The concealed carry clip 200 also has a longitudinal clip portion 403 that is generally orthogonal to the mounting tab 401.The clip portion 403 is equipped with three friction through-hole, in-relief punchings 404A, 404B and 404C, which facilitate drawing back the slide of the Glock handgun with the thumb and index finger.", "Referring now to FIG.", "5, a replacement rear cover plate 501 for the slide of an M&P Smith and Wesson handgun has been equipped with treaded screw holes 502L and 502R.", "It will be noted that the cover plate 501 is further equipped with an upper projection 503 Referring now to FIG.", "6, an improved concealed carry clip 601 for an M&P handgun is equipped with a mounting tab 602 having with two apertures 603L and 603R, by means of which the clip 601 will be attached with machine screw 604L and 604R to the replacement aluminum rear cover plate 401.The mounting tab 502 fits snugly against the upper projection 503 so that shearing loads on the securing screws 604L and 604R are reduced.", "In addition, the projection also limits or prevents any rocking motion of the mounting tab 602 on the securing machine screws 604L and 604R when there is not a tight fit between the apertures 603L and 603R and the screws 604L and 604R, respectively.", "The clip 601 also has a longitudinal clip portion 605 that is generally orthogonal to the mounting tab 602.The clip portion 605 is equipped with three friction through-hole, in-relief punchings 606A, 606B and 606C, which facilitate drawing back the slide of the M&P handgun with the thumb and index finger.", "Referring now to FIG.", "7, a replacement rear cover plate 701 for the slide of an XD handgun has been equipped with threaded screw holes 702L and 702R.", "Referring now to FIG.", "8, an improved concealed carry clip 801 for an XD handgun is equipped with a mounting tab 802 having two apertures 803L and 803R, by means of which the clip 801 will be attached with machine screws 804L and 804R to the replacement aluminum rear cover plate 701.The concealed carry clip 801 also has a clip portion 805 that is generally orthogonal to the mounting tab 802.The clip portion 805 is equipped with three friction through-hole, in-relief punchings 806A, 806B and 806C, which facilitate drawing back the slide of the XD handgun with the thumb and index finger.", "Referring now to FIG.", "9, a replacement rear cover plate 901 for the slide of a Clock 42 handgun has been equipped with treaded screw holes 902L and 902R.", "Referring now to FIG.", "10, an improved concealed carry clip 1000 for a Clock 42 handgun is equipped with a mounting tab 1002 having two apertures 1003L and 1003R, by means of which the clip 1000 will be attached with machine screws 1004L and 1004R to the replacement aluminum rear cover plate 901.The concealed carry clip 1000 also has a concave portion 1005 that fits within a recess in the slide of the handgun.", "A longitudinal clip portion of the concealed carry clip 1001 is generally orthogonal to the mounting tab 1002.The concealed carry clip 1000 is equipped with four stamped protrusions 1006A, 1006B, 1006C and 1006D, which facilitate drawing back the slide of the XD handgun with the thumb and index finger by enhancing grip.", "Referring now to FIG.", "11, a replacement rear cover plate 1101 for the slide of a Springfield Armory XD-S handgun has been equipped with treaded screw holes 1102L and 1102R.", "Referring now to FIG.", "12, an improved concealed carry clip 1200 for an XD-S handgun is equipped with a mounting tab 1202 having two apertures 1203L and 1203R, by means of which the clip 1200 will be attached with machine screws 1204L and 1204R to the replacement aluminum rear cover plate 1101.The concealed carry clip 1200 also has a concave portion 1205 that fits flush against the slide of the handgun before bending out and becoming a longitudinal clip portion 1201, which is spaced from the slide of the XD-S handgun.", "The longitudinal clip portion 1201 is generally orthogonal to the mounting tab 1202.The concealed carry clip 1200 is equipped with four stamped apertures 1206A, 1206B, 1206C and 1206D, which facilitate drawing back the slide of the XD-S handgun with the thumb and index finger by enhancing grip.", "Referring now to FIG.", "13, the improved concealed carry clip 1200 of FIG.", "12 is shown in a different view, in which the inside surface of the longitudinal clip portion 1201 is visible.", "Referring now to FIG.", "14, the replacement rear cover plate 1101 and the improved concealed carry clip 1200 of FIGS.", "12 and 13 have been mounted on a Springfield Armory XD-S handgun.", "It will be noted that this clip, as is the improved concealed carry clip 10000 of FIG.", "10 are both designed to mount behind the chamber of the handgun (item 107, in the case of the XD-S handgun).", "This feature has two benefits: 1) It enables the handgun to be carried lower on the carrier's body, as only the very rear portion of the handgun—essentially, only that portion of the handgun that is behind the midpoint of the rear sight—is exposed above the belt or waistband of the carrier; 2) The longitudinal portion of the carry clip need not dip below the ejector and chamber so as not to interfere with the functioning of the handgun when firing.", "Referring now to FIG.", "15, a shorter version 1500 of the concealed carry clip 1200 is mounted on the same XD-S handgun.", "The forward end of concealed carry clip 1500 is about even with the pivot pin 109 of the ejector 108.Thus, when the handgun 100 is fired, the forward end of the clip 1500 need not be pushed aside as spent cartridges are ejected.", "In the case of concealed carry clip 1200, the clip must be pushed aside by the ejector 108 as spent cartridges are ejected.", "Although this is deemed to be an acceptable and entirely functional design, the design of the shorter concealed carry clip 1500 is deemed to be the preferred embodiment.", "Though the improved concealed carry clips have, to date, been designed for Clock®, M&P® and Springfield Armory® XD handguns, the concealed carry clips may be adapted for use on other similarly constructed handguns.", "Thus, although only four embodiments of the improved concealed carry clip have been shown and described herein, it will be obvious to those having ordinary skill in the art that changes and modifications may be made thereto without departing from the scope and the spirit of the invention as hereinafter claimed." ] ]
Patent_15872896
[ [ "WIRELESS COMMUNICATION METHOD USING HYBRID BEAMFORMING AND APPARATUS THEREFORE", "The disclosure relates to a wireless communication technology, and more specifically, to a method and an apparatus for connecting a wireless backhaul by generating reception status information, and interference information or location information, on the basis of a beamforming signal at the time of configuration of a wireless backhaul between base stations through beamforming." ], [ "1.A method of connecting a wireless backhaul, the method comprising: receiving, by a small-cell base station (BS), a plurality of beamforming signals from a macro-cell BS to connect a wireless backhaul; collecting information on the plurality of beamforming signals' interference with a terminal connected to the small-cell BS or location information of the terminal; and connecting, by the small-cell BS, a wireless backhaul to the macro-cell BS based on reception status information of the received plurality of beamforming signals and the interference information or the location information.", "2.The method of claim 1, wherein the connecting of the wireless backhaul comprises transmitting, by the small-cell BS, the reception status information of the plurality of beamforming signals and the interference information or the location information to the macro-cell BS.", "3.The method of claim 1, wherein the connecting of the wireless backhaul comprises: selecting, by the small-cell BS, a beamforming signal for connecting the wireless backhaul based on the reception status information of the plurality of beamforming signals and the interference information; and transmitting, by the small-cell BS, a selection result to the macro-cell BS.", "4.The method of claim 1, wherein the plurality of beamforming signals include preset training symbols.", "5.The method of claim 4, wherein the collecting of the interference information or the location information comprises receiving interference information of the beamforming signals including the training symbols from the terminal.", "6.A method of connecting a wireless backhaul, the method comprising: transmitting, by a macro-cell base station (BS), a plurality of beamforming signals to a small-cell BS to connect a wireless backhaul; receiving, by the macro-cell BS, reception status information of the plurality of beamforming signals and information on the plurality of beamforming signals' interference with a terminal connected to the small-cell BS or location information of the terminal from the small-cell BS; and selecting one of the plurality of beamforming signals based on the reception status information of the plurality of beamforming signals and the interference information or the location information, and connecting a wireless backhaul to the small-cell BS.", "7.The method of claim 6, wherein the f connecting of the wireless backhaul comprises nulling beamforming toward the terminal based on the location information of the terminal.", "8.An apparatus for connecting a wireless backhaul, the apparatus comprising: a wireless transceiving unit configured to transmit and receive wireless signals; and a control unit configured to control the wireless transceiving unit, wherein the control unit comprises: a beamforming search module configured to control the wireless transceiving unit to exchange a plurality of beamforming signals having different directivities between a macro-cell base station (BS) and a small-cell BS, and to check information on reception status of the plurality of beamforming signals at the small-cell BS; a collection module configured to collect information on the plurality of beamforming signals' interference with a terminal connected to the small-cell BS or location information of the terminal; and a backhaul connecting module configured to select one of the plurality of beamforming signals based on the reception status information of the plurality of beamforming signals and the interference information or the location information, and connect a wireless backhaul between the macro-cell BS and the small-cell BS." ], [ "<SOH> BACKGROUND <EOH>The discussion in this section is only to provide background information of the present embodiment and does not constitute an admission of prior art.", "Unlike the past when radio communication provided a service centered on voice traffic, the number of backhaul links for transmitting hundreds of megabytes per second (Mbps) or more are gradually increasing with the rapid development of third generation/fourth generation (3G/4G) mobile communication for providing a multimedia service.", "Also, with the advent of next-generation mobile communication such as 5G mobile communication, a necessity of wireless transmission of gigabytes per second (Gbps) or more is increasing such that frequencies of a millimeter wave band which facilitate ensuring a bandwidth of hundreds of MHz or higher are attracting attention.", "Further, 3G partnership project (3GPP) began a discussion about standardization.", "In this way, considerable discussions about 5G element technology development and 5G standard technology are taking place among companies and organizations.", "Here, millimeter waves denote electromagnetic waves having a frequency of 30 GHz or higher (30 to 300 GHz).", "Currently, 28 GHz, 38 GHz, 60 GHz, 70 GHz, and the like are taken into consideration as frequencies to be used in 5G mobile communication networks.", "Such a millimeter wave band shows a larger transmission loss and a lower diffractive feature than an existing 4G frequency band, and thus a beamforming technology for concentrating radio waves toward a desired direction using a plurality of antennas is generally used in wireless transmission.", "Meanwhile, 5G mobile communication employing such millimeter waves requires a large number of small cells to cover many shadow areas caused by a high transmission rate and a low diffractive feature.", "Therefore, in consideration of capital expenditure (CAPEX) and operating expenses (OPEX), a necessity of low-priced small cells increases.", "However, when a wired transmission network is used to backhaul data from a small cell to a macro cell, a large amount of cost is required to build the wired network separately from the low-priced small cell.", "As a solution to this problem, a self-backhauling technology for separating, while using the same frequency/time resources, a wireless backhaul between a macro-cell base station (BS) and a small-cell BS and a wireless link between a BS and a terminal according to a beamforming technique is attracting attention.", "In a general wireless backhaul, a backhauling frequency band between BSs and a frequency band used for a terminal are different to prevent interference.", "In this case, since it is necessary to assign predetermined frequency resources for backhauling, a frequency capacity of a small-cell BS is reduced.", "On the other hand, the millimeter wave band enables backhauling in which the same frequency/time resources are used due to high directivity based on beamforming.", "However, even when a beamforming-based wireless backhaul is implemented between a macro-cell BS and a small-cell BS, there is a problem of interference between each cell and a terminal.", "Since a macro-cell BS transmits and receives radio waves in a relatively larger range than a small-cell BS, there is no significant difference in distance and angle between a small-cell BS and terminals connected to the small-cell BS from the viewpoint of the macro-cell BS, and thus interference occurs even when radio waves are transmitted and received based on beamforming.", "This problem worsens in a downlink in which the macro-cell BS emits a wireless backhauling wave with high transmission power.", "In other words, during beamforming-based wireless backhauling, there is an interference factor for a terminal that receives a downlink signal from a small-cell BS." ], [ "<SOH> SUMMARY <EOH>The disclosure is directed to providing a method and apparatus for connecting a wireless backhaul by generating reception status information and interference information or location information on the basis of a beamforming signal, which can minimize interference with a terminal receiving a downlink signal from a small-cell base station (BS), during a beamforming process for a wireless backhaul between a macro-cell BS and the small-cell BS.", "Objects of the disclosure are not limited to those mentioned above, and unmentioned other objects will be apparently understood by those of ordinary skill in the art to which the disclosure pertains from the description below.", "One aspect of the disclosure provides a method of connecting a wireless backhaul, the method including: receiving, by a small-cell base station (BS), a plurality of beamforming signals from a macro-cell BS to connect a wireless backhaul; collecting information on the plurality of beamforming signals' interference with a terminal connected to the small-cell BS or location information of the terminal; and connecting, by the small-cell BS, a wireless backhaul to the macro-cell BS based on reception status information of the received plurality of beamforming signals and the interference information or the location information.", "Another aspect of the disclosure provides a method of connecting a wireless backhaul, the method including: transmitting, by a macro-cell BS, a plurality of beamforming signals to a small-cell BS to connect a wireless backhaul; receiving, by the macro-cell BS, reception status information of the plurality of beamforming signals and information on the plurality of beamforming signals' interference with a terminal connected to the small-cell BS or location information of the terminal from the small-cell BS; and selecting one of the plurality of beamforming signals based on the reception status information of the plurality of beamforming signals and the interference information or the location information, and connecting a wireless backhaul to the small-cell BS.", "Another aspect of the disclosure provides an apparatus for connecting a wireless backhaul, the apparatus including: a wireless transceiver configured to transmit and receive wireless signals; and a control unit configured to control the wireless transceiver, wherein the control unit includes a beamforming search module configured to control the wireless transceiver to exchange a plurality of beamforming signals having different directivities between a macro-cell BS and a small-cell BS, and to check information on reception status of the plurality of beamforming signals at the small-cell BS; a collection module configured to collect information on the plurality of beamforming signals' interference with a terminal connected to the small-cell BS or location information of the terminal; and a backhaul connecting module configured to select one of the plurality of beamforming signals based on the reception status information of the plurality of beamforming signals and the interference information or the location information, and connect a wireless backhaul between the macro-cell BS and the small-cell BS.", "According to the disclosure, when a backhaul is connected using a wireless network, information on interference with a terminal caused by the wireless backhaul is checked, and beamforming is performed in consideration of the interference information.", "In this way, it is possible to reduce radio wave interference with a terminal connected to a small-cell base station (BS) caused by the wireless backhaul from a macro-cell BS.", "In particular, according to the disclosure, even when the same frequency/time resources are used in radio communication between a terminal and a BS to implement a wireless backhaul, radio wave interference with the terminal is minimized such that a stable service can be provided.", "Effects of the disclosure are not limited to those mentioned above, and other effects of the disclosure will be apparently understood by those of ordinary skill in the art to which the disclosure pertains from the description below." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS The present application is a continuation of International Patent Application No.", "PCT/KR2016/001420, filed on Feb. 12, 2016, which is based upon and claims the benefit of priority to Korean Patent Application No.", "10-2015-0101157, filed on Jul.", "16, 2015.The disclosures of the above-listed applications are hereby incorporated by reference herein in their entirety.", "TECHNICAL FIELD The disclosure relates to a method and apparatus for reducing interference with a terminal caused by sidelobes in a hybrid beamforming structure.", "BACKGROUND The discussion in this section is only to provide background information of the present embodiment and does not constitute an admission of prior art.", "Unlike the past when radio communication provided a service centered on voice traffic, the number of backhaul links for transmitting hundreds of megabytes per second (Mbps) or more are gradually increasing with the rapid development of third generation/fourth generation (3G/4G) mobile communication for providing a multimedia service.", "Also, with the advent of next-generation mobile communication such as 5G mobile communication, a necessity of wireless transmission of gigabytes per second (Gbps) or more is increasing such that frequencies of a millimeter wave band which facilitate ensuring a bandwidth of hundreds of MHz or higher are attracting attention.", "Further, 3G partnership project (3GPP) began a discussion about standardization.", "In this way, considerable discussions about 5G element technology development and 5G standard technology are taking place among companies and organizations.", "Here, millimeter waves denote electromagnetic waves having a frequency of 30 GHz or higher (30 to 300 GHz).", "Currently, 28 GHz, 38 GHz, 60 GHz, 70 GHz, and the like are taken into consideration as frequencies to be used in 5G mobile communication networks.", "Such a millimeter wave band shows a larger transmission loss and a lower diffractive feature than an existing 4G frequency band, and thus a beamforming technology for concentrating radio waves toward a desired direction using a plurality of antennas is generally used in wireless transmission.", "Meanwhile, 5G mobile communication employing such millimeter waves requires a large number of small cells to cover many shadow areas caused by a high transmission rate and a low diffractive feature.", "Therefore, in consideration of capital expenditure (CAPEX) and operating expenses (OPEX), a necessity of low-priced small cells increases.", "However, when a wired transmission network is used to backhaul data from a small cell to a macro cell, a large amount of cost is required to build the wired network separately from the low-priced small cell.", "As a solution to this problem, a self-backhauling technology for separating, while using the same frequency/time resources, a wireless backhaul between a macro-cell base station (BS) and a small-cell BS and a wireless link between a BS and a terminal according to a beamforming technique is attracting attention.", "In a general wireless backhaul, a backhauling frequency band between BSs and a frequency band used for a terminal are different to prevent interference.", "In this case, since it is necessary to assign predetermined frequency resources for backhauling, a frequency capacity of a small-cell BS is reduced.", "On the other hand, the millimeter wave band enables backhauling in which the same frequency/time resources are used due to high directivity based on beamforming.", "However, even when a beamforming-based wireless backhaul is implemented between a macro-cell BS and a small-cell BS, there is a problem of interference between each cell and a terminal.", "Since a macro-cell BS transmits and receives radio waves in a relatively larger range than a small-cell BS, there is no significant difference in distance and angle between a small-cell BS and terminals connected to the small-cell BS from the viewpoint of the macro-cell BS, and thus interference occurs even when radio waves are transmitted and received based on beamforming.", "This problem worsens in a downlink in which the macro-cell BS emits a wireless backhauling wave with high transmission power.", "In other words, during beamforming-based wireless backhauling, there is an interference factor for a terminal that receives a downlink signal from a small-cell BS.", "SUMMARY The disclosure is directed to providing a method and apparatus for connecting a wireless backhaul by generating reception status information and interference information or location information on the basis of a beamforming signal, which can minimize interference with a terminal receiving a downlink signal from a small-cell base station (BS), during a beamforming process for a wireless backhaul between a macro-cell BS and the small-cell BS.", "Objects of the disclosure are not limited to those mentioned above, and unmentioned other objects will be apparently understood by those of ordinary skill in the art to which the disclosure pertains from the description below.", "One aspect of the disclosure provides a method of connecting a wireless backhaul, the method including: receiving, by a small-cell base station (BS), a plurality of beamforming signals from a macro-cell BS to connect a wireless backhaul; collecting information on the plurality of beamforming signals' interference with a terminal connected to the small-cell BS or location information of the terminal; and connecting, by the small-cell BS, a wireless backhaul to the macro-cell BS based on reception status information of the received plurality of beamforming signals and the interference information or the location information.", "Another aspect of the disclosure provides a method of connecting a wireless backhaul, the method including: transmitting, by a macro-cell BS, a plurality of beamforming signals to a small-cell BS to connect a wireless backhaul; receiving, by the macro-cell BS, reception status information of the plurality of beamforming signals and information on the plurality of beamforming signals' interference with a terminal connected to the small-cell BS or location information of the terminal from the small-cell BS; and selecting one of the plurality of beamforming signals based on the reception status information of the plurality of beamforming signals and the interference information or the location information, and connecting a wireless backhaul to the small-cell BS.", "Another aspect of the disclosure provides an apparatus for connecting a wireless backhaul, the apparatus including: a wireless transceiver configured to transmit and receive wireless signals; and a control unit configured to control the wireless transceiver, wherein the control unit includes a beamforming search module configured to control the wireless transceiver to exchange a plurality of beamforming signals having different directivities between a macro-cell BS and a small-cell BS, and to check information on reception status of the plurality of beamforming signals at the small-cell BS; a collection module configured to collect information on the plurality of beamforming signals' interference with a terminal connected to the small-cell BS or location information of the terminal; and a backhaul connecting module configured to select one of the plurality of beamforming signals based on the reception status information of the plurality of beamforming signals and the interference information or the location information, and connect a wireless backhaul between the macro-cell BS and the small-cell BS.", "According to the disclosure, when a backhaul is connected using a wireless network, information on interference with a terminal caused by the wireless backhaul is checked, and beamforming is performed in consideration of the interference information.", "In this way, it is possible to reduce radio wave interference with a terminal connected to a small-cell base station (BS) caused by the wireless backhaul from a macro-cell BS.", "In particular, according to the disclosure, even when the same frequency/time resources are used in radio communication between a terminal and a BS to implement a wireless backhaul, radio wave interference with the terminal is minimized such that a stable service can be provided.", "Effects of the disclosure are not limited to those mentioned above, and other effects of the disclosure will be apparently understood by those of ordinary skill in the art to which the disclosure pertains from the description below.", "BRIEF DESCRIPTION OF DRAWINGS The accompanying drawings which are included as a portion of the detailed description to help understanding of the disclosure provide embodiments of the disclosure and illustrate technical features of the disclosure along with the detailed description.", "FIG.", "1 is a diagram schematically showing a radio communication system in which a wireless backhaul according to the disclosure is implemented.", "FIGS.", "2 to 4 are message sequence diagrams showing processes of connecting a wireless backhaul in a radio communication system according to an embodiment of the disclosure.", "FIG.", "5 is a diagram showing a configuration of a wireless backhaul connecting apparatus according to an embodiment of the disclosure.", "FIG.", "6 is a flowchart illustrating a method of connecting a wireless backhaul according to the disclosure.", "FIG.", "7 is a schematic diagram showing a beamforming control status according to an embodiment of the disclosure.", "FIG.", "8 is a schematic diagram showing a beamforming control status according to another embodiment of the disclosure.", "DETAILED DESCRIPTION Hereinafter, exemplary embodiments of the disclosure will be described in detail with reference to the accompanying drawings.", "The detailed description set forth below in connection with the accompanying drawings is intended as a description of exemplary embodiments of the disclosure and is not intended to represent the only embodiment in which the disclosure can be implemented.", "The detailed description includes specific details for providing a thorough understanding.", "However, it will be apparent to those of ordinary skill in the art that the disclosure can be implemented without these specific details.", "In some cases, well-known structures and devices may be omitted or shown in the form of a block diagram related to a core function of each structure and device to avoid obscuring the concept of the disclosure.", "Throughout the specification, when a part is referred to as “comprising” or “including” a component, this indicates that the part may further include another component instead of excluding another component unless particularly stated otherwise.", "The terms such as “unit,” “-er (or),” and “module” used in the specification refer to a unit that performs at least one function or operation, and may be implemented in hardware, software or a combination of hardware and software.", "Also, “a” or “an,” “one,” “the,” and the like may be used to include both the singular form and the plural form unless indicated otherwise in the context of the disclosure (particularly in the context of the claims) or clearly denied in the context.", "In addition, terminology including ordinal numbers such as first and second may be used to describe a variety of components.", "The terminology is only used to distinguish one component from other components and is not used to limit the components.", "For example, a second component may be referred to as a first component without departing from the scope of the disclosure, and similarly, the first component may also be referred to as the second component.", "Specific terms used in the following description are provided only to help understanding of the disclosure, and the use of the specific terms may be modified in a different form without departing from the technical spirit of the disclosure.", "The disclosure relates to the formation of a wireless backhaul for a base station (BS) that processes a wireless connection with a user.", "Here, backhauling denotes collecting and transferring data between a BS and a backbone network.", "In the case of a radio communication system, a backhaul may be generally connected between a BS and a backbone network in a wired or wireless manner Here, a BS may indicate a node B, an evolved node B (eNodeB), an access point (AP), a radio access station (RAS), a base transceiver station (BTS), a mobile multihop relay (MMR)-BS, and the like, and may include functions of all or some of a nodeB, an eNodeB, an AP, an RAS, a BTS, an MMR-BS, and the like.", "In particular, in the disclosure, a fifth generation (5G)-based mobile communication system whose small-cell BS is installed in a shadow area or an area in which communication is concentrated within the coverage of a macro-cell BS is taken into consideration.", "In the disclosure, backhauling includes the formation of a backhaul between the macro-cell BS and the small-cell BS.", "For reference, the macro-cell BS denotes a BS that is applied to a general mobile communication system and has high transmission power and wide coverage, and the small-cell BS denotes, as a comparative concept of a macro cell, a BS that has lower transmission power and smaller coverage than the macro-cell BS.", "Such a small-cell BS is a common designation of, for example, BS equipment with a low output of 10 W or less per antenna, a pico-cell, a femto-cell, a micro-cell, and the like.", "For reference, the small-cell BS is disposed in a shadow area, in a boundary area between BSs, indoors, or the like and used for covering the shadow area, traffic distribution in a high traffic area, or transmission in a heterogeneous network such as mobile communication, wireless fidelity (WiFi), and the like.", "An apparatus and method for connecting a wireless backhaul according to the disclosure will be described below based on a radio communication environment including a macro-cell BS and a small-cell BS with reference to FIGS.", "1 to 8.FIG.", "1 is a diagram schematically showing a radio communication system in which a wireless backhaul according to an embodiment of the disclosure is implemented.", "As shown in FIG.", "1, a mobile communication system according to an embodiment of the disclosure includes at least one terminal 100, a small-cell BS 200, and a macro-cell BS 300.The terminal 100 denotes user equipment (UE) that is connected to a radio communication network and transmits and receives data.", "Here, “terminal” may be replaced by terms such as “UE,” “mobile station (MS),” “mobile subscriber station (MSS),” “subscriber station (SS),” “advanced mobile station (AMS),” “wireless terminal (WT),” “machine-type communication (MTC) device,” “machine-to-machine (M2M) device,” “device-to-device (D2D) device,” “station (STA),” and the like.", "However, a terminal mentioned in the specification is not limited thereto and can be any device that is connected to a radio communication network provided by the disclosure.", "The small-cell BS 200 and the macro-cell BS 300 provide a wireless link to the terminal 100 in the radio communication system, and a wireless backhaul is connected between the small-cell BS 200 and the macro-cell BS 300.In particular, the small-cell BS 200 makes a connection with the at least one terminal 100 within the communication coverage thereof and exchanges data with the at least one terminal 100.Here, with regard to the terminal 100, data transmitted to the terminal 100 is referred to as a downlink signal, and data transmitted from the terminal 100 is referred to as an uplink signal.", "An uplink signal of the at least one terminal 100 that is received from the at least one terminal 100 by the small-cell BS 200 is transmitted to the macro-cell BS 300 through the wireless backhaul and then transferred to a wired backhaul and a backbone network through the macro-cell BS 300.On the other hand, a downlink signal transferred from the backbone network and the wired backhaul is transferred from the macro-cell BS 300 to the small-cell BS 200 through the wireless backhaul and then transmitted to the at least one terminal 100 through the small-cell BS 200.These small-cell BS 200 and macro-cell BS 300 have wireless backhaul connecting apparatuses shown in FIG.", "5 according to the disclosure and may connect a wireless backhaul through the wireless backhaul connecting apparatuses.", "For reference, the wireless backhaul may be connected for each of a downlink and an uplink.", "Since the disclosure is intended to connect a wireless backhaul while minimizing interference with the terminal 100, the following description will be made on the basis of the formation of a wireless backhaul for a downlink in which relatively severe interference with the terminal 100 may occur.", "However, this is not intended to limit the scope of the disclosure, and the disclosure can also be applied to an uplink as necessary.", "The small-cell BS 200 and the macro-cell BS 300 having the wireless backhaul connecting apparatuses according to the disclosure perform a beamforming process to determine a beam direction for connecting a wireless backhaul.", "In particular, the macro-cell BS 300 performs downlink beamforming for a wireless backhaul for a downlink signal.", "Specifically, the macro-cell BS 300 emits a plurality of beamforming signals one by one in different directions and receives feedback information of the plurality of beamforming signals from the small-cell BS 200.At this time, the small-cell BS 200 receives a plurality of beamforming signals including training symbols from the macro-cell BS 300 and generates reception status information using the received beamforming signals.", "Also, the small-cell BS 200 may collect interference information of each of the plurality of beamforming signals from the terminal 100 connected thereto.", "Subsequently, a beamforming signal for a downlink is determined from among the plurality of beamforming signals based on the reception status information and the interference information.", "According to an embodiment of the disclosure, the small-cell BS 200 may feed the interference information and the reception status information back to the macro-cell BS 300 so that the macro-cell BS 300 may select a beamforming signal and connect a wireless backhaul.", "According to another embodiment of the disclosure, the small-cell BS 200 may select one of the plurality of beamforming signals based on the interference information and the reception status information and then transmit selection information to the macro-cell BS 300 so that the macro-cell BS 300 may connect a wireless backhaul based on the selection information.", "Here, beamforming may be performed using a millimeter wave band.", "For reference, millimeter waves have a low penetrability and a very small beam width.", "Therefore, BSs are connected on a one-to-one basis through precise adjustment of antennas thereof, and it is possible to obtain a high quality when a wireless backhaul is implemented.", "Also, the small-cell BS 200 makes a wireless connection with the terminal 100 in the communication coverage thereof and exchanges a downlink signal and an uplink signal with the terminal 100 through connected wireless resources.", "At this time, the communication coverage of the small-cell BS 200 may be an area 200a indicated by an alternate long and short dash line in FIG.", "1.A wireless link between the small-cell BS 200 and the terminal 100 and the wireless backhaul between the macro-cell BS 300 and the small-cell BS 200 may use the same frequency/time resources.", "Further, the macro-cell BS 300 may connect the wireless backhaul to the small-cell BS 200, exchange a downlink signal/uplink signal through the wireless backhaul, and simultaneously exchange a downlink signal/uplink signal with an arbitrary terminal (not shown) in the communication coverage thereof by connecting a wireless link to the terminal.", "The communication coverage of the macro-cell BS 300 may be an area 300a indicated by a broken line in FIG.", "1.Next, a process of connecting a wireless backhaul in the radio communication system having the above-described structure will be described in detail with reference to FIGS.", "2 to 4.FIG.", "2 is a message sequence diagram showing a process of connecting a wireless backhaul according to an embodiment of the disclosure.", "Referring to FIG.", "2, it is possible to see a process in which the macro-cell BS 300 transmits beamforming signals and the terminal 100 and the small-cell BS 200 generate information based on the beamforming signals transmitted by the macro-cell BS 300 such that a wireless backhaul is connected.", "The macro-cell BS 300 radially transmits beamforming signals, and the signals may arrive at the small-cell BS 200 and the terminal 100 within the beamforming signal range thereof (S200a and S200b).", "The terminal 100 generates interference information based on the beamforming signals arriving from the macro-cell BS 300 (S202) and transmits the generated interference information to the small-cell BS 200 through a wireless link between the terminal 100 and the small-cell BS 200 (S206).", "Specifically, the terminal 100 may recognize a plurality of beamforming signals on the basis of training signals included in the plurality of beamforming signals and generate the interference information using a signal-to-noise ratio (SNR) and the like.", "Here, the plurality of beamforming signals act as noise for a downlink signal received by the terminal 100.The plurality of beamforming signals can be transmitted at the same time or one by one.", "The small-cell BS 200 generates reception status information based on the beamforming signals arriving from the macro-cell BS 300 (S204).", "Here, the reception status information may include a received signal intensity.", "The small-cell BS 200 transmits the interference information received from the terminal 100 and the reception status information generated by itself to the macro-cell BS 300 (S208).", "The macro-cell BS 300 selects a beamforming signal for connecting a wireless backhaul based on the received interference information and reception status information (S210).", "The macro-cell BS 300 connects a wireless backhaul by beamforming with the selected signal toward the small-cell BS 200 (S212).", "FIG.", "3 is a message sequence diagram showing a process of connecting a wireless backhaul according to another embodiment of the disclosure.", "Referring to FIG.", "3, in the other embodiment of the disclosure, it is possible to see a process in which the macro-cell BS 300 transmits beamforming signals and the terminal 100 and the small-cell BS 200 generate information based on the beamforming signals transmitted by the macro-cell BS 300 such that a wireless backhaul is connected, like in FIG.", "2.Specifically, the macro-cell BS 300 transmits a plurality of beamforming signals one by one in different directions.", "At this time, the plurality of beamforming signals are radially transmitted and arrive at the small-cell BS 200 and the terminal 100 near the small-cell BS 200 (S300a and S300b).", "The terminal 100 generates interference information based on the beamforming signals arriving from the macro-cell BS 300 (S302) and transmits the generated interference information to the small-cell BS 200 through a wireless link between the terminal 100 and the small-cell BS 200 (S306).", "The small-cell BS 200 generates reception status information based on the beamforming signals arriving from the macro-cell BS 300 (S304).", "The small-cell BS 200 selects a beamforming signal to be received based on the interference information received from the terminal 100 and the reception status information generated by itself (S308).", "The small-cell BS 200 transmits selection information to the macro-cell BS 300 (S310).", "The macro-cell BS 300 connects a wireless backhaul by beamforming toward the small-cell BS 200 based on the received selection information (S312).", "According to the embodiments shown in FIGS.", "2 and 3, in a non-line-of-sight (NLOS) environment in which an obstacle and the like is present, it is possible to check beam reception status and interference in which influence of the obstacle is taken into consideration and perform optimal beamforming.", "Also, in a line-of-sight (LOS) environment, it is possible to connect a wireless backhaul which can minimize interference based on location information of the terminal 100.FIG.", "4 is a message sequence diagram showing a process of connecting a wireless backhaul using location information according to still another embodiment of the disclosure.", "Referring to FIG.", "4, the macro-cell BS 300 radially transmits beamforming signals, and the signals arrive at the small-cell BS and the terminal within the beamforming signal range thereof (S400a and S400b).", "The small-cell BS 200 generates reception status information based on the beamforming signals arriving from the macro-cell BS 300 (S402).", "When it is determined based on the reception status information that it is easy to collect location information of the terminal 100 (when the small-cell BS 200 and the macro-cell BS 300 are not in an NLOS environment), the small-cell BS 200 may collect location information of the terminal (S404).", "Here, the location information may be received from the terminal 100 or collected from anywhere such as upper and lower structures of a communication network in which the location information of the terminal 100 exists.", "The small-cell BS 200 transmits the collected location information of the terminal 100 and the reception status information generated by itself to the macro-cell BS 300 (S406).", "The macro-cell BS 300 nulls a beamforming signal directed to the terminal 100 based on the received reception status information and location information of the terminal 100 (S408).", "The macro-cell BS 300 transmits beamforming signals other than the nulled beamforming signal and connects a wireless backhaul to the small-cell BS 200 using the transmitted beamforming signals (S410).", "Next, a configuration and operation of a wireless backhaul connecting apparatus applied to the above-described small-cell BS 200 and macro-cell BS 300 will be described with reference to FIGS.", "5 and 6.FIG.", "5 is a diagram showing a structure of a wireless backhaul connecting apparatus according to an embodiment of the disclosure.", "The wireless backhaul connecting apparatus is provided in the small-cell BS 200 and the macro-cell BS 300.As shown in FIG.", "5, the wireless backhaul connecting apparatus according to an embodiment of the disclosure may include a wireless transceiving unit 10 and a control unit 20.Among the components shown in FIG.", "5, the wireless transceiving unit 10 is a component for exchanging wireless signals between BSs.", "In an embodiment, the wireless transceiving unit 10 may transmit and receive a plurality of beamforming signals having different directivities.", "Also, the wireless transceiving unit 10 may receive interference information generated by the terminal 100 and transmit and receive reception status information and selection information of a beamforming signal.", "In another embodiment, the wireless transceiving unit 10 may transmit and receive location information of the terminal 100.Next, the control unit 20 is a component for checking information received through the wireless transceiving unit 10, controlling the wireless transceiving unit 10, and connecting a wireless backhaul by generating information and selecting a beamforming signal.", "The control unit 20 may include a beamforming search module 22, a collection module 24, and a backhaul connecting module 26.The beamforming search module 22 is a component for controlling the wireless transceiving unit 10 so that a plurality of beamforming signals having different directivities are transmitted from the macro-cell BS 300 and received by the small-cell BS 200, and for checking information on reception status of the plurality of beamforming signals at the small-cell BS 200.The plurality of beamforming signals may include training symbols.", "The collection module 24 is a component for collecting information on the plurality of beamforming signals' interference with the terminal 100 connected to the small-cell BS 200 or location information of the terminal 100.The collection module 24 may use the wireless transceiving unit 10 for information collection and provide collected information to the backhaul connecting module 26.The backhaul connecting module 26 is a component for selecting one of the plurality of beamforming signals based on the reception status information of the plurality of beamforming signals and the interference information or the location information and for connecting a wireless backhaul between the macro-cell BS 300 and the small-cell BS 200.The backhaul connecting module 26 may null a beamforming signal of a specific direction or transmit a beamforming signal in a selected direction.", "FIG.", "6 is a flowchart illustrating a wireless backhaul connecting process performed by the above-described wireless backhaul connecting apparatus.", "Referring to FIG.", "6, a wireless backhaul connecting apparatus performs a beam search using a plurality of beamforming signals (S100).", "During this process, the wireless backhaul connecting apparatus in the macro-cell BS 300 transmits a plurality of beamforming signals one by one in different directions.", "At this time, the plurality of beamforming signals are radially transmitted.", "The wireless backhaul connecting apparatus in the small-cell BS 200 receives the beamforming signals that have been radially transmitted.", "The beamforming signals may include training symbols.", "The wireless backhaul connecting apparatus in the small-cell BS 200 generates reception status information based on the beamforming signal (S110).", "Also, the wireless backhaul connecting apparatus in the small-cell BS 200 collects interference information or location information based on the signal (S120).", "The wireless backhaul connecting apparatus in the small-cell BS 200 transmits the collected information to the wireless backhaul connecting apparatus in the macro-cell BS 300.A wireless backhaul connecting apparatus selects a beamforming signal using the reception status information and the interference information or the location information (S130).", "The selection may be made by any of the wireless backhaul connecting apparatus in the small-cell BS 200 and the wireless backhaul connecting apparatus in the macro-cell BS 300.The wireless backhaul connecting apparatus connects a wireless backhaul between the BSs using the selected beamforming signal (S140).", "This process may be performed by transmitting the at least one beamforming signal selected by the wireless backhaul connecting apparatus or by nulling at least one beamforming signal that interferes with the terminal 100.FIG.", "7 is a schematic diagram showing a beamforming control status according to an embodiment of the disclosure.", "When there is no obstacle between the small-cell BS 200 and the macro-cell BS 300, operation may be performed as shown in the message sequence diagram of FIG.", "4, and the macro-cell BS 300 nulls a beamforming signal directed to the terminal 100.In other words, the macro-cell BS 300 reduces an antenna gain of the beamforming signal directed to the terminal 100, thereby preventing the beamforming signal from being transferred to the terminal 100.FIG.", "8 is a schematic diagram showing a beamforming control status according to an embodiment of the disclosure.", "When there is an obstacle between the small-cell BS 200 and the macro-cell BS 300, operation may be performed as shown in the message sequence diagram of FIG.", "2 or 3.Here, some of a plurality of beamforming signals emitted from the macro-cell BS 300 may not be transferred to the small-cell BS 200 due to an obstacle.", "In the above environment, it is assumed as a result of a search that each of a first beamforming signal 300b and a second beamforming signal 300c is reflected by an obstacle and then transferred to the small-cell BS 200 along a changed path and reception status of the case is the best.", "At this time, the terminal 100 connected to the small-cell BS 200 is more affected by the second beamforming signal 300c than the first beamforming signal 300b that is transmitted along a farther path.", "In other words, interference information of the second beamforming signal 300c measured by the terminal 100 is greater than interference information of the first beamforming signal 300b.", "In this case, the first beamforming signal 300b may be selected to connect a wireless backhaul between the small-cell BS 200 and the macro-cell BS 300.Although the specification and drawings illustrate exemplary configurations of devices, embodiments of the subject matter and the functional operations described in this specification can be provided in another type of digital electronic circuitry, or in computer software, firmware, or hardware, including the structures disclosed in this specification and their structural equivalents, or in combinations of one or more thereof.", "Embodiments of the subject matter described in this specification can be implemented as one or more computer program products, that is, one or more modules of computer program instructions encoded on a tangible program storage medium for execution by, or to control the operation of, the devices according to the disclosure.", "A computer-readable medium can be a machine-readable storage device, a machine-readable storage substrate, a memory device, a composition of matter having influence on a machine-readable propagated signal, or a combination of one or more thereof.", "While this specification contains details of many specific embodiments, these should not be construed as limitations on the scope of any invention or what can be claimed, but rather as descriptions of features specific to particular embodiments of a particular invention.", "Certain features that are described in this specification in the context of separate embodiments can also be implemented in combination in a single embodiment.", "Conversely, various features that are described in the context of a single embodiment can also be implemented in multiple embodiments separately or in any suitable sub-combination.", "Further, although features may be described as acting in certain combinations and even initially claimed as such, one or more features from a claimed combination can be excised from the combination in some cases, and the claimed combination may be directed to a sub-combination or variation of a sub-combination.", "Similarly, while operations are depicted in the drawings in a particular order, this should not be understood as requiring that such operations be performed in the particular order shown or in sequential order, or that all illustrated operations be performed, to achieve desirable results.", "In particular cases, multitasking and parallel processing may be advantageous.", "Also, the separation of various system components in the embodiments described above should not be understood as requiring such separation in all embodiments, and it should be understood that the described program components and systems can generally be integrated together in a single software product or packaged into multiple software products." ] ]
Patent_15872898
[ [ "DEVICE AND METHOD FOR CALIBRATING A WIDEBAND RADIO FREQUENCY RECEIVE CHAIN", "A device and method for calibrating a wideband radio frequency receive chain are disclosed.", "In one aspect, the device includes a wideband radio frequency receive chain and a processing module configured to perform a spectral analysis.", "The receive chain includes an input block and a radio frequency processing assembly.", "The device is configured to implement a first calibration phase of the input block and a second calibration phase of the receive chain." ], [ "1.A method of calibrating the power of a wideband radio frequency receive chain configured to receive an input radio frequency signal from a receiving antenna, in a frequency band, the method implemented in a calibration device comprising the wideband radio frequency receive chain and a spectral analyzer, the receive chain including an input block connected at the input of a radio frequency processing assembly, the method comprising: a first calibration phase of the input block, comprising, for at least one temperature value of the input block and a frequency, generating a given power spectral density of noise, using a noise source configured to be selected and controlled from the input block, and computing and storing at least one equivalent power spectral density of noise returned at the input of the input block; and a second calibration phase of the power gain of the receive chain, comprising: generating a given power spectral density of noise, measuring a power spectral density of noise at the output of the receive chain, and computing a power gain of the receive chain as a function of the power spectral density of noise at the output of the receive chain and the equivalent power spectral density of noise returned at the input corresponding to the given power spectral density of noise generated in the generating.", "2.The method according to claim 1, wherein, in the first calibration phase of the input block, the computation comprises: obtaining a power gain of the input block for the temperature value and the frequency, generating a noise having a given power spectral density of noise and measuring a power spectral density of noise at the output of the input block, and computing an equivalent power spectral density of noise brought down to the input of the input block as a function of the power gain of the input block and the power spectral density of noise at the output of the input block.", "3.The method according to claim 1, further comprising repeating the first calibration phase of the input block for a plurality of frequencies in the frequency band of the receive chain and/or a plurality of temperature values of the input block.", "4.The method according to claim 1, wherein the spectral analyzer is a processing module of the radio frequency processing assembly, and wherein the measurement of the power spectral density of noise at the output of the receive chain is obtained at the output of the processing module.", "5.The method according to claim 1, wherein the spectral analyzer is a calibrated auxiliary receiver comprising a spectral analyzer and the receive chain including an output block connected to the output of the radio frequency processing assembly, configured to switch between a first position for conveying the radio frequency signal toward a primary output of the receive chain and a second position for conveying the radio frequency signal toward an auxiliary output of the receive chain, on which the calibrated auxiliary receiver is connected during calibration, the method further comprising a first phase for calibration of the output block, comprising computing a gain deviation between the primary output and the auxiliary output, for at least the frequency and the temperature value of the input block considered in the calibration of the input block, and, in the second phase, the computing of the power gain of the receive chain also accounting for the gain deviation introduced by the output block.", "6.A device for calibrating the power of a wideband radio frequency receive chain, comprising a wideband radio frequency receive chain configured to receive an input radio frequency signal from a receiving antenna, in a frequency band, the receive chain including an input block, a radio frequency processing assembly, and a spectral analyzer, wherein the input block includes a noise source connected at the input of a switching member able to connect the noise source to the input of a block of downstream circuits of the input block, the output of the block of downstream circuits being connected at the input of the radio frequency processing assembly, the device configured to implement of a calibration method according to claim 1.7.The device according to claim 6, wherein the receive chain has a specific background noise, and the power of the noise introduced by the noise source is greater than the power of the background noise specific to the receive chain.", "8.The device according to claim 6, wherein the switching member is a switch configured to switch between a first position for injecting, in the block of downstream circuits of the input block, the input radio frequency signal, and a second injection position, in the block of downstream circuits of the input block, noise generated by the noise source.", "9.The device according to claim 6, wherein the noise source is a noise diode.", "10.The device according to claim 6, wherein the spectral analyzer is a processing module belonging to the radio frequency processing assembly, the measurement of the power spectral density of noise at the output of the receive chain being obtained at the output of the processing module.", "11.The device according to claim 6, further comprising an output block, connected to the output of the radio frequency processing assembly, comprising a switching member able to switch between a first position for conveying the radio frequency signal toward a primary output of the receive chain and a second position for conveying the radio frequency signal toward an auxiliary output of the receive chain, the spectral analyzer belonging to a calibrated auxiliary receiver connected, during the calibration, to the auxiliary output.", "12.A radiogoniometry device comprising a plurality of wideband radio frequency receive chains, each connected to a receiving antenna, and a computation unit able to compute an angle of incidence of a radio frequency signal received by the receiving antennas, comprising, for each of the receive chains, a power calibration device according to claim 6." ], [ "<SOH> BACKGROUND <EOH>" ], [ "<SOH> SUMMARY OF CERTAIN INVENTIVE ASPECTS <EOH>Certain aspects of the described technology aim to resolve the aforementioned drawbacks, by proposing a calibration method and device for a wideband radio frequency receive chain, which are less complex and have better calibration precision than the known systems.", "To that end, one aspect relates to a method for calibrating the power of a wideband radio frequency receive chain, able to receive an input radio frequency signal from a receiving antenna, in a frequency band, implemented in a calibration device comprising said wideband radio frequency receive chain and a capability able to perform a spectral analysis, said receive chain including an input block connected at the input of a radio frequency processing assembly, the method comprising: a first calibration phase of the input block, comprising, for at least one temperature value of said input block and a frequency, generating a given power spectral density of noise, using a noise source able to be selected and controlled from the input block, then computing and storing at least one equivalent power spectral density of noise returned at the input of the input block, a second calibration phase for the power gain of the receive chain comprising: generating a given power spectral density of noise; measuring a power spectral density of noise at the output of the receive chain; computing a power gain of the receive chain as a function of the power spectral density of noise at the output of the receive chain and the equivalent power spectral density of noise returned at the input corresponding to the given power spectral density of noise.", "Advantageously, the use of a noise source in the input block of a receive chain allows a more precise power calibration of the receive chain, while minimizing the induced hardware complexity.", "The method according to the described technology may also have one or more of the features below: in the first calibration phase of the input block, the computation comprises: obtaining a power gain of the input block for said temperature value and said frequency; generating a noise having a given power spectral density of noise and measuring a power spectral density of noise at the output of the input block; computing an equivalent power spectral density of noise returned at the input of said input block as a function of the power gain of the input block and the power spectral density of noise at the output of the input block.", "the first calibration phase of the input block is repeated for a plurality of frequencies in the frequency band of the receive chain and/or a plurality of temperature values of the input block.", "the capability configured to perform a spectral analysis being a processing module of the radio frequency processing assembly, the measurement of the power spectral density of noise at the output of the receive chain is obtained at the output of said processing module.", "the capability configured to perform a spectral analysis being a calibrated auxiliary receiver comprising a spectral analyzer and the receive chain including an output block connected to the output of the radio frequency processing assembly, able to switch between a first position for conveying the radio frequency signal toward a primary output of the receive chain and a second position for conveying the radio frequency signal toward an auxiliary output of the receive chain, on which the calibrated auxiliary receiver is connected during calibration, the method further includes a first phase for calibration of the output block, consisting of computing a gain deviation between said primary output and said auxiliary output, for at least the frequency and the temperature value of the input block considered in the first step for calibration of the input block, and, in the second phase, the step for computing the power gain of the receive chain also accounting for said gain deviation introduced by the output block.", "Another aspect relates to a device for calibrating the power of a wideband radio frequency receive chain, comprising a wideband radio frequency receive chain able to receive an input radio frequency signal from a receiving antenna, in a frequency band, the receive chain including an input block, a radio frequency processing assembly, and a capability configured to perform a spectral analysis, characterized in that the input block includes a noise source connected at the input of a switching member able to connect the noise source to the input of a block of downstream circuits of the input block, the output of said block of downstream circuits being connected at the input of the radio frequency processing assembly, the device enabling the implementation of a calibration method according to the preceding method.", "The device according to the described technology may also have one or more of the features below: said receive chain having a specific background noise, the power of the noise introduced by said noise source is greater than the power of said background noise specific to the receive chain.", "the switching member is a switch able to switch between a first position for injecting, in the block of downstream circuits of the input block, the input radio frequency signal, and a second injection position, in the block of downstream circuits of the input block, noise generated by the noise source.", "said noise source is a noise diode.", "the capability configured to perform a spectral analysis is a processing module with which the radio frequency processing assembly is provided, the measurement of the power spectral density of noise at the output of the receive chain being obtained at the output of said processing module.", "the device further includes an output block, connected to the output of the radio frequency processing assembly, comprising a switching member able to switch between a first position for conveying the radio frequency signal toward a primary output of the receive chain and a second position for conveying the radio frequency signal toward an auxiliary output of the receive chain ( 60 ), the capability configured to perform a spectral analysis being a calibrated auxiliary receiver comprising a spectral analyzer and connected, during the calibration, to the auxiliary output.", "Yet another aspect also relates to a radiogoniometry device comprising a plurality of wideband radio frequency receive chains, each connected to a receiving antenna, and a computation unit able to compute an angle of incidence of a radio frequency signal received by said receiving antennas, characterized in that it includes, for each of said receive chains, a power calibration device according to the preceding device." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of International Application No.", "PCT/EP2016/067521, filed Jul.", "22, 2016, which claims the benefit under 35 U.S.C.", "§ 119 of French Application No.", "15 01577, filed Jul.", "23, 2015, each of which is herein incorporated by reference in its entirety.", "BACKGROUND Technological Field The described technology generally relates to a device and method for calibrating the measurement of the power of signals with a wideband radio frequency receive chain.", "The described technology is particularly applicable in the field of wideband amplitude radiogoniometry for localizing emission sources in radio frequency bands.", "Description of the Related Technology A radio frequency receive chain is branched at the output of a receiving antenna and comprises an input block and a set of hardware modules and digital computation capability, for example a computation processor.", "In the field of radiogoniometry, several receiving antennas and several receive chains are used to allow the measurement of the arrival direction of the signal coming from an emission source.", "In this field, several techniques exist.", "One of these is commonly used due to the simplicity of its implementation; this is amplitude radiogoniometry.", "The latter is based on the use of the power of the signals delivered by an array of directional antennas, the pointing of which is generally evenly distributed over the angular range of interest, very generally 360° in the horizontal plane to measure the relative bearing.", "For this radiogoniometry, it is necessary to have good measuring precision of the power of the radio frequency signal received by each receiving antenna.", "However, each receive chain causes its own specific measuring imprecisions.", "In order to obtain good measuring precision, it is necessary to calibrate each radio frequency receive chain.", "A wideband receive chain is made up of a set of several processing modules, connected to one another by cables that may be several meters long.", "It is known to use a system for injecting and measuring a calibration signal, which requires a wideband radio frequency signal generator injected at the input of the receive chain and a device for measuring the power of said radio frequency signal at the input and output of the receive chain.", "Such a system is complex and cumbersome.", "U.S. Pat.", "No.", "6,700,537 B1 describes a system for calibrating a wideband radio frequency receiver of a location system, including at least two processing channels.", "This patent proposes to use a single noise source for the calibration, the noise being distributed over the processing channels.", "This calibration system requires a system for distributing the noise toward the various channels and allows only a relative calibration between the various channels used.", "SUMMARY OF CERTAIN INVENTIVE ASPECTS Certain aspects of the described technology aim to resolve the aforementioned drawbacks, by proposing a calibration method and device for a wideband radio frequency receive chain, which are less complex and have better calibration precision than the known systems.", "To that end, one aspect relates to a method for calibrating the power of a wideband radio frequency receive chain, able to receive an input radio frequency signal from a receiving antenna, in a frequency band, implemented in a calibration device comprising said wideband radio frequency receive chain and a capability able to perform a spectral analysis, said receive chain including an input block connected at the input of a radio frequency processing assembly, the method comprising: a first calibration phase of the input block, comprising, for at least one temperature value of said input block and a frequency, generating a given power spectral density of noise, using a noise source able to be selected and controlled from the input block, then computing and storing at least one equivalent power spectral density of noise returned at the input of the input block, a second calibration phase for the power gain of the receive chain comprising: generating a given power spectral density of noise; measuring a power spectral density of noise at the output of the receive chain; computing a power gain of the receive chain as a function of the power spectral density of noise at the output of the receive chain and the equivalent power spectral density of noise returned at the input corresponding to the given power spectral density of noise.", "Advantageously, the use of a noise source in the input block of a receive chain allows a more precise power calibration of the receive chain, while minimizing the induced hardware complexity.", "The method according to the described technology may also have one or more of the features below: in the first calibration phase of the input block, the computation comprises: obtaining a power gain of the input block for said temperature value and said frequency; generating a noise having a given power spectral density of noise and measuring a power spectral density of noise at the output of the input block; computing an equivalent power spectral density of noise returned at the input of said input block as a function of the power gain of the input block and the power spectral density of noise at the output of the input block.", "the first calibration phase of the input block is repeated for a plurality of frequencies in the frequency band of the receive chain and/or a plurality of temperature values of the input block.", "the capability configured to perform a spectral analysis being a processing module of the radio frequency processing assembly, the measurement of the power spectral density of noise at the output of the receive chain is obtained at the output of said processing module.", "the capability configured to perform a spectral analysis being a calibrated auxiliary receiver comprising a spectral analyzer and the receive chain including an output block connected to the output of the radio frequency processing assembly, able to switch between a first position for conveying the radio frequency signal toward a primary output of the receive chain and a second position for conveying the radio frequency signal toward an auxiliary output of the receive chain, on which the calibrated auxiliary receiver is connected during calibration, the method further includes a first phase for calibration of the output block, consisting of computing a gain deviation between said primary output and said auxiliary output, for at least the frequency and the temperature value of the input block considered in the first step for calibration of the input block, and, in the second phase, the step for computing the power gain of the receive chain also accounting for said gain deviation introduced by the output block.", "Another aspect relates to a device for calibrating the power of a wideband radio frequency receive chain, comprising a wideband radio frequency receive chain able to receive an input radio frequency signal from a receiving antenna, in a frequency band, the receive chain including an input block, a radio frequency processing assembly, and a capability configured to perform a spectral analysis, characterized in that the input block includes a noise source connected at the input of a switching member able to connect the noise source to the input of a block of downstream circuits of the input block, the output of said block of downstream circuits being connected at the input of the radio frequency processing assembly, the device enabling the implementation of a calibration method according to the preceding method.", "The device according to the described technology may also have one or more of the features below: said receive chain having a specific background noise, the power of the noise introduced by said noise source is greater than the power of said background noise specific to the receive chain.", "the switching member is a switch able to switch between a first position for injecting, in the block of downstream circuits of the input block, the input radio frequency signal, and a second injection position, in the block of downstream circuits of the input block, noise generated by the noise source.", "said noise source is a noise diode.", "the capability configured to perform a spectral analysis is a processing module with which the radio frequency processing assembly is provided, the measurement of the power spectral density of noise at the output of the receive chain being obtained at the output of said processing module.", "the device further includes an output block, connected to the output of the radio frequency processing assembly, comprising a switching member able to switch between a first position for conveying the radio frequency signal toward a primary output of the receive chain and a second position for conveying the radio frequency signal toward an auxiliary output of the receive chain (60), the capability configured to perform a spectral analysis being a calibrated auxiliary receiver comprising a spectral analyzer and connected, during the calibration, to the auxiliary output.", "Yet another aspect also relates to a radiogoniometry device comprising a plurality of wideband radio frequency receive chains, each connected to a receiving antenna, and a computation unit able to compute an angle of incidence of a radio frequency signal received by said receiving antennas, characterized in that it includes, for each of said receive chains, a power calibration device according to the preceding device.", "BRIEF DESCRIPTION OF THE DRAWINGS Other features and advantages of the described technology will emerge from the description thereof provided below, for information and non-limitingly, in reference to the appended figures, in which: FIG.", "1 schematically shows a power calibration device for a wideband receive chain according to a first embodiment; FIGS.", "2 and 3 schematically show the main modules of an input block of a wideband receive chain according to a first embodiment; FIG.", "4 is a flowchart of the main steps of a method for calibrating a wideband receive chain according to one embodiment; FIG.", "5 schematically shows a device for calibrating a wideband receive chain according to a second embodiment; FIGS.", "6 and 7 are the main modules of an output block of the calibration device of FIG.", "5; FIG.", "8 schematically shows the device for calibrating a wideband receive chain of FIG.", "5 in calibration mode; FIG.", "9 schematically shows a radiogoniometry according to one embodiment.", "DETAILED DESCRIPTION OF CERTAIN INVENTIVE EMBODIMENTS FIG.", "1 schematically illustrates a device for calibrating a wideband radio frequency receive chain 2.In this example, this is a superheterodyne receiver followed by a spectral analysis.", "The receive chain 2 is connected as output of an antenna 4, and comprises several connected modules, including an input block 6, normally connected as close as possible to the antenna.", "In one embodiment, the input block 6 is connected as output of the antenna 4 by a cable 5, the length of which is about 0 to 20 centimeters.", "The output of the input block 6 is connected to a radio frequency processing assembly 8, comprising hardware modules and digital computation capability.", "The radio frequency processing assembly 8 comprises, in this example, a frequency change (transposition) module 10, able to convert a radio frequency signal RF with a first given frequency into a signal with a second frequency FI, called intermediate frequency, generally lower than the first frequency.", "At the output of the frequency change module 10, an analog-digital converter 12 is connected, at the output of which a signal processing module 14 is connected, able to perform a spectral analysis processing operation.", "In one embodiment, the signal processing module 14 is an FPGA located on the same electronic board as the analog-digital converter 12.The various modules making up the receive chain 2 are connected via cables 16, 18, the cumulative length of which may exceed approximately ten meters.", "These cables cause power losses of the radio frequency signal.", "Let RFi be the radio frequency signal at the input of the receiver 2, and RFs the radio frequency signal at the output of the receiver 2.The radio frequency receive chain 2 is able to operate in a frequency band [F1, F2], for example from 2 to 18 GHz.", "The power of the signal is measured at the end of the receive chain, such that knowing the power gain of this receive chain makes it possible to deduce the power of the signal at the input of said chain.", "The described technology indeed makes it possible to compute the power gain of a receive chain, for various frequency and temperature values of the input block 6, as explained in detail below.", "This power gain corresponds to the ratio of the output power Ps to the input power Pi.", "It may be expressed in decibels (dB) as follows: G d   B = 10  log  ( P s P i ) = 10  log  ( P s ) - 10  log  ( P i ) Where log( ) is the base 10 logarithmic function.", "In other words, the power gain of the receive chain is the difference between the power of the output signal and the power of the input signal, both expressed in logarithmic units.", "The power of the output signal is calculated at the end of the spectral analysis.", "It is the square of the modulus of the complex signal, within the mathematical meaning, corresponding to a frequency step or Fourier transform box.", "The power gain of a receive chain 2 as schematically shown in FIG.", "1 depends, inter alia, on the installed cables 16, 18 and the temperature of the various electronic blocks 6, 10, 12.The calibration may ideally be redone upon each significant temperature change indicated by a sensor integrated into one of the blocks.", "Otherwise, it may only be done upon initialization of the system, assuming that the differential gain deviations related to the temperature change are small.", "The receive chain has its own background noise, depending on various components of this receive chain.", "This specific noise of the receive chain is not known precisely; nevertheless, it is possible to determine a maximum specific noise level of the receiver.", "In one embodiment of the calibration device of the described technology, illustrated in FIGS.", "2 and 3, the input block 6 of a wideband radio frequency receive chain 2 comprises a block 22 of upstream circuits and a block 24 of traditional downstream circuits.", "For example, the block 22 comprises a frequency band limitation filter and protective circuits with respect to strong signals, and the block 24 comprises amplifiers and variable attenuators.", "It is desirable to introduce the noise as far upstream as possible, therefore to limit the block 22 to a minimum of functions.", "The input block 6 further comprises a noise source 26 and a switching member 28.These elements 26 and 28 are added to perform the calibration function.", "The switching member 28 is for example a switch, which, when it is in a position POS2, makes it possible to switch the circuit so as to inject the noise provided by the noise source 26 at the input of the block of downstream circuits 24.Thus, the switching member 28 makes it possible to choose between the calibration mode of the receive chain 2 (POS2), in which the noise is injected into the receiver 2 (illustrated in FIG.", "3), and the nominal operating mode (illustrated in FIG.", "2), in which the switch is in a position POS1.Alternatively, the switching member 28 is a coupler.", "The noise source 26 provides a noise in a given spectral density calibration mode, the spectral density being a power per frequency bandwidth (expressed for example in dBm/MHz).", "The spectral density is therefore normalized.", "The noise source 26 is a component added into the input block 6, having determined characteristics to obtain a good calibration precision.", "In particular, the noise source 26 is chosen so as to provide a noise with a power higher than that of the noise specific to the receive chain.", "For example, to obtain a precision of 0.5 dB, the noise power of the noise source 26 must be 10 dB higher than the noise power specific to the receive chain brought down to the input.", "In one embodiment, to produce the noise source 26, a component is used of the wideband noise diode type having an ENR (excess noise ratio) of 30 dB.", "Advantageously, such a component is very small.", "Alternatively, an amplifier is used as noise source 26, its input being connected to an appropriate charge and its output delivering the desired noise.", "Thus, the addition of such a component 26 and a switch 28 into the input block of a wideband radio frequency receive chain has a very small bulk.", "Furthermore, when the switching member 28 is in the position POS1 illustrated in FIG.", "2, the receiver operates in nominal receiving mode without disruption.", "In calibration mode, the noise source 26 is powered, the switching member 28 is in the position POS2, and the noise is conveyed at the input of the downstream block 24.FIG.", "4 is a flowchart of the main steps of a method for calibrating the wideband receive chain according to one embodiment.", "The method comprises two phases, a first phase 40 for calibrating the input block 6 with respect to the noise source and a second phase 42 for calibrating the entire receive chain.", "During a first step 44 of the first phase 40, a calibration table of the input block, which provides the input-output power gain of this block, based on the frequency Fi of the signal Rfi at the input in the temperature Tk of the input block 6 is obtained.", "One therefore has a first calibration table for the input block comprising power gain values of the input block G1(Fi, Tk).", "This first table is established in the plant, by performing successive injections of radio frequency signals, and power measurements at the input and output of the input block.", "Desirably, a set of temperature values Tk ranging from −40° C. to +85° C. are considered, and a set of frequency values Fi comprised in the frequency band of the receive chain, with a predetermined frequency pitch, for example of about 10 MHz.", "Alternatively, a single temperature value corresponding to an anticipated use of the receiver is considered.", "Next, during a step 46 for determining spectral density of noise, the switching member 28 is switched into calibration mode (POS2) and the noise source 26 is powered.", "The spectral density of noise N1(Fi,Tk) is measured at the output of the input block, for each frequency Fi and each temperature Tk of the first calibration table of the input block.", "To carry out this step, a measuring instrument, for example a spectrum analyzer, is connected at the output of the input block.", "During a step 48 for computing equivalent spectral density, one computes, for each measured output spectral density of noise N1(Fi,Tk), the equivalent spectral density brought down to the input of the input block, denoted Ne(Fi,Tk): Ne(Fi,Tk)=N1(Fi,Tk)−G1(Fi,Tk), as long as these expressions are expressed in logarithmic units that are consistent with respect to one another.", "The equivalent spectral density brought down to the input of the input block is therefore obtained through a mathematical computation.", "These computed values are stored in a second calibration table of the input block.", "The gain of the switching member 28 is supposed to be identical in both positions POS1 and POS2.In the calibration phase 42 of the receive chain, during a step 50, the switching member 28 is in position POS2 to be in the calibration mode, a noise coming from the noise source 26 being injected at the input of the block 24.The output spectral density of noise of the spectral analysis Nm(Fi) is measured at each frequency Fi.", "Knowing the temperature Tk of the input block, and the input equivalent spectral density, the power gain of the receive chain is computed during a computation step 52 as follows: Gr(Fi,Tk)=Nm(Fi)−Ne(Fi,Tk), as long as these expressions are expressed in logarithmic units that are consistent with respect to one another.", "The power gain values of the receive chain are stored in a calibration table of the receive chain.", "In the nominal usage mode of the receiver, the stored power gain values of the receive chain are used to determine the power Pi of a radio frequency signal RFi at an antenna output from the power Ps measured at the output of the receive chain, as a function of the frequency f of the signal RF and the measured or estimated temperature T of the input block: Pi=Ps−Gr(f,T), as long as these expressions are expressed in logarithmic units that are consistent with respect to one another.", "FIG.", "5 shows a device for calibrating a receive chain 60 that does not include spectral analysis.", "The receive chain 60 includes an input block 62, which receives a radio frequency signal coming from an antenna 4, and a radio frequency processing assembly 64, able to include active and passive elements, including cables.", "The input block 62 is similar to the input block 6 previously described.", "In this embodiment, the input block 60 includes a block 66 of upstream circuits and a block 68 of downstream circuits, similar to the blocks 22 and 24 previously described.", "It also comprises a noise source 70 and a first switching member 72.The calibration device of FIG.", "5 also comprises an output block 74 that is added to allow the calibration.", "This output block 74 comprises a second switching member 76, able to switch between a first position POSa for conveying the radio frequency signal toward a downstream circuit module 78, the output Sf of which provides the output radio frequency signal of the receiver.", "This position POSa corresponds to a nominal operating mode.", "The second switching member 76 comprises a second position POSb, which conveys the radio frequency signal toward an auxiliary output Saux on which, in the calibration mode, a calibrated auxiliary receiver is connected comprising a spectral analyzer.", "To perform the calibration, a first calibration phase of the input 62 and output 74 blocks is carried out.", "The input block 62 is similar to the input block 6 previously described.", "To calibrate the output block 74, similarly to what was described for the calibration of the input block 6, first the second switching member 76 is placed in the position POSa and the power gain G2 (FIG.", "6) is measured between the input E2 and the output Sr, as a function of the frequency and the temperature of the input block 62, in dB.", "Next, the switching member 76 is in position POSb, and the power gain G3 is measured between the input E2 and the auxiliary output Saux as a function of the frequency and the temperature of the input block 62, in dB.", "The gain deviation G4 in dB, between the main output and the auxiliary output, for the considered frequencies and temperatures of the input block, is computed and stored in a calibration table of the output block, or therefore: G4(Fi,Tk)=G2(Fi,Tk)−G3(Fi,Tk).", "Next, in a second phase, the entire receive chain is calibrated.", "The input 62 and output 74 blocks are placed in calibration mode via the respective switching members 72 and 76, as illustrated in FIG.", "8.To carry out this step, a calibrated measuring instrument, for example a spectrum analyzer, is connected at the auxiliary output of the output block 74.As input, one injects the noise, via the noise source 70, with spectral density of noise Ne(Fi,Tk)=N1(Fi,Tk)−G1(Fi,Tk).", "As output, one measures the output spectral density of noise Nma(Fi).", "One then computes Gra(Fi,Tk)=Nma(Fi)−Ne(Fi,Tk).", "In this embodiment, the power gain of the receive chain is given by: Gr(Fi,Tk)=Gra(Fi,Tk)+G4(Fi,Tk) The power gain values of the receive chain, for given frequency Fi and temperature Tk values, are stored in a calibration table of the receive chain.", "In the nominal usage mode of the receiver 60, the stored power gain values of the receive chain are used to determine the power Pe of a radio frequency signal RF at an antenna output from the power Pr measured at the output of the receive chain, as a function of the frequency f of the signal RF and the measured or estimated temperature T of the input block: Pe=Pr−Gr(f,T) The described technology is particularly applicable in the field of amplitude radiogoniometry, making it possible to establish the angle of arrival θ of a radio frequency signal in a given coordinate system, for example the coordinate system of a carrier, such as an aircraft or a ship, on which the radiogoniometer is placed.", "A radio goniometer uses n directional antennas, n being greater than or equal to 2.For example, a radio goniometer 100 with four antennas and four receive chains is schematically illustrated in FIG.", "9 Each of the receive antennas A1 to A4 is oriented along a predetermined receiving angle in a coordinate system, for example at +45 degrees, +135 degrees, +225 degrees and +315 degrees.", "An incident radio frequency signal RF is received by these four antennas A1 to A4; their differences in orientation cause them to deliver different powers.", "A respective receive chain 110, 120, 130 and 140 is connected at the output of each antenna, and the power of the signals respectively received makes it possible to compute the angle of arrival θ of the incident radio frequency signal RF.", "The computation is done by a computation module 150.The computation is done using any known amplitude radiogoniometry method.", "The precision of the computed angle depends on the quality of the measurement of the power of each receive chain.", "Advantageously, each receive chain 110, 120, 130 and 140 is calibrated by applying one of the embodiments described above.", "Thus, for each receive chain, power gain Gr,i calibration tables are computed, with i going from 1 to 4 in the preceding example (four antennas), as a function of various frequency and temperature values.", "The computed gain values Gr,i are stored and provided to the module 150, which performs the computations.", "Advantageously, the radiogoniometry precision is increased.", "The described technology in particular applies to the gain calibration of wideband receive chains, including modules distributed over one or several tens of meters, in particular for the case where such receivers are already on board a carrier.", "Indeed, in this case, the access to certain modules of the receive chain is difficult.", "Advantageously, the described technology allows the calibration of the power gain of the entire receive chain without precise knowledge of its component modules, with the exception of input blocks 6 or 62 and output blocks 74.While there have been shown and described and pointed out the fundamental novel features of the invention as applied to certain inventive embodiments, it will be understood that the foregoing is considered as illustrative only of the principles of the invention and not intended to be exhaustive or to limit the invention to the precise forms disclosed.", "Modifications or variations are possible in light of the above teachings.", "The embodiments discussed were chosen and described to provide the best illustration of the principles of the invention and its practical application to enable one of ordinary skill in the art to utilize the invention in various embodiments and with various modifications as are suited to the particular use contemplate.", "All such modifications and variations are within the scope of the invention as determined by the appended claims when interpreted in accordance with the breadth to which they are entitled." ] ]
Patent_15872901
[ [ "Medical Implantable Occlusion Device, And Method For Implantation Thereof", "A medical implantable occlusion device is disclosed comprising a fabric of at least one thread and a structural formation thereof having a collapsed and an expanded shape, the formation comprises a proximal and a distal portion, a longitudinal axis extending between the proximal and distal portion, wherein at least one of the proximal and distal portions comprises a peripheral edge having a first and a second radius of curvature in a direction substantially perpendicular to the longitudinal axis, wherein the first radius of curvature is different from the second radius of curvature." ], [ "1.A medical implantable paravalvular leakage occlusion device for occlusion of paravalvular leakage at a heart valve, comprising: a braiding of at least one thread and a structural formation thereof having a collapsed and an expanded shape, said formation comprises a proximal and a distal portion, a longitudinal axis extending between said proximal and distal portion, wherein at least one of said proximal and distal portion comprises a peripheral edge having a first and a second edge section, wherein at least one of the first edge section and the second edge section is inwardly curved relative the longitudinal axis, and wherein the inwardly curved edge section is configured to substantially follow a valve curvature of said valve when said device is expanded.", "2.Occlusion device according to claim 1, wherein the first and the second edge section are inwardly curved relative the longitudinal axis, and wherein at least one of the first and the second edge section is configured to substantially follow a valve curvature of said valve when said device is expanded.", "3.Occlusion device according to claim 2, wherein a radius of curvature of said first edge section is different from a radius of curvature of said second edge section relative said longitudinal axis.", "4.Occlusion device according to claim 1, wherein said device is rotational symmetric around said longitudinal axis.", "5.Occlusion device according to claim 1, wherein at least one of said proximal portion and said distal portion comprises a connecting member to which at least one end of said of at least one thread is fixed.", "6.Occlusion device according to claim 5, said at least one connecting member is configured to be attached to a delivery device.", "7.Occlusion device according to claim 5, wherein ends of said at least one thread are fixed to said at least one connecting member, and wherein said distal portion comprises returning loops of said at least one thread whereby opposite ends of said at least one thread forming said distal portion are fixed to the same connecting member; and wherein said device comprises a braiding from a plurality of threads forming a closed braided distal wall at said distal portion.", "8.Occlusion device according to claim 1, wherein said peripheral edge comprises edge sections that are alternatingly inwardly and outwardly curved relative the longitudinal axis.", "9.Occlusion device according to claim 1, wherein said peripheral edge comprises radially opposed edge sections having substantially the same radius of curvature relative the longitudinal axis.", "10.Occlusion device according to claim 9, wherein first radially opposed edge sections of said peripheral edge has a radius of curvature relative the longitudinal axis that is larger than the radius of curvature of second radially opposed edge sections relative the longitudinal axis.", "11.Occlusion device according to claim 1, wherein said peripheral edge defines a generally rectangular shape of said proximal or distal portion.", "12.Occlusion device according to claim 1, wherein said peripheral edge comprises at least two edge sections that are inwardly curved relative the longitudinal axis.", "13.Occlusion device according to claim 1, wherein at least one of said proximal and distal portion is deflected towards the other portion with an angle.", "14.Occlusion device according to claim 1, wherein one of said proximal and distal portion has a larger diameter than the other portion, whereby an overlap between the proximal and distal portion is created.", "15.Occlusion device according to claim 14, wherein the proximal portion is deflected towards the distal portion with an angle, the distal portion is deflected towards the proximal portion with an angle, and wherein the distal portion overlaps the proximal portion in the radial direction of said device.", "16.Occlusion device according to claim 1, comprising at least one marker element for aiding in orienting said occlusion device.", "17.Occlusion device according to claim 16, wherein said at least one marker element is arranged on one of said proximal and distal portion at a position corresponding substantially to the location of said peripheral edge, and/or wherein said marker element comprises a radiopaque material.", "18.Occlusion device according to claim 1, comprising a connecting member attached to one of said distal and proximal portion, said connecting member being configured for connection to a delivery device in a predetermined orientation.", "19.Occlusion device according to claim 1, comprising a waist of reduced cross section between said distal and proximal portion.", "20.Occlusion device according to claim 1, wherein said at least one thread, forming said waist, is twisted around said longitudinal axis between said proximal and distal portion.", "21.A medical implantable paravalvular leakage occlusion device for occlusion of paravalvular leakage at a heart valve, comprising: a braiding of at least one thread and a structural formation thereof having a collapsed and an expanded shape, said formation comprises a proximal and a distal portion, a longitudinal axis extending between said proximal and distal portion, wherein at least one of said proximal and distal portion comprises a peripheral edge having a first and a second edge section, wherein the first and the second edge section are inwardly curved relative the longitudinal axis.", "22.Occlusion device according to claim 21, wherein at least one of the first and the second edge section is configured to substantially follow a valve curvature of said valve when said device is expanded.", "23.Occlusion device according to claim 22, wherein a radius of curvature of said first edge section is different from a radius of curvature of said second edge section relative said longitudinal axis.", "24.Occlusion device according to claim 21, wherein said device is rotational symmetric around said longitudinal axis.", "25.Occlusion device according to claim 21, wherein said peripheral edge comprises edge sections that are alternatingly inwardly curved and outwardly curved relative the longitudinal axis.", "26.Occlusion device according to claim 21, wherein said peripheral edge comprises radially opposed edge sections having substantially the same radius of curvature relative the longitudinal axis.", "27.Occlusion device according to claim 21, wherein one of said proximal and distal portion has a larger diameter than the other portion, and wherein an overlap between the proximal and distal portion is provided.", "28.Occlusion device according to claim 27, wherein the proximal portion is deflected towards the distal portion with an angle, the distal portion is deflected towards the proximal portion with an angle, and wherein the distal portion overlaps the proximal portion in the radial direction of said device.", "29.A medical implantable paravalvular leakage occlusion device for occlusion of paravalvular leakage at a heart valve, comprising: a braiding of at least one thread and a structural formation thereof having a collapsed and an expanded shape, said formation comprises a proximal and a distal portion, a longitudinal axis extending between said proximal and distal portion, wherein at least one of said proximal and distal portion comprises a peripheral edge having a first and a second edge section, wherein at least one of the first edge section and the second edge section is inwardly curved relative the longitudinal axis, and wherein said device is rotational symmetric around said longitudinal axis.", "30.Occlusion device according to claim 29, wherein the first and the second edge section are inwardly curved relative the longitudinal axis, and wherein at least one of the first and the second edge section is configured to substantially follow a valve curvature of said valve when said device is expanded.", "31.Occlusion device according to claim 30, wherein a radius of curvature of said first edge section is different from a radius of curvature of said second edge section relative to said longitudinal axis.", "32.Occlusion device according to claim 29, wherein said peripheral edge comprises edge sections that are alternatingly inwardly curved relative the longitudinal axis and outwardly curved relative the longitudinal axis.", "33.Occlusion device according to claim 29, wherein said peripheral edge comprises radially opposed edge sections having substantially the same radius of curvature relative the longitudinal axis.", "34.Occlusion device according to claim 29, wherein one of said proximal and distal portion has a larger diameter than the other portion, whereby an overlap between the proximal and distal portion is created.", "36.Occlusion device according to claim 35, wherein the proximal portion is deflected towards the distal portion with an angle, the distal portion is deflected towards the proximal portion with an angle, and wherein the distal portion overlaps the proximal portion in the radial direction of said device." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Various intravascular deliverable devices are used for treating specific conditions via access through body lumina, such as patient's circulatory system.", "The target site may for instance be an atrial or ventricular septum having a defective opening to be occluded, such as devices for treating septal defects and the like.", "In certain circumstances, it may be necessary to occlude a patient's lumen, vessel, chamber, channel, hole, or cavity such as to stop blood flow there through.", "One such condition known in the art is Para-Valvular Leak (PVL) which may occur in association with surgical implantation of prosthetic valves in the heart, and with interventional valve implantations in general, i.e.", "transcatheter aortic valve intervention (TAVI).", "When the prosthetic valve is fixed by sutures micro-holes are created where the sutures penetrate the tissue.", "These micro-holes can become dilated over time and grow larger and also merge together, thereby creating undesired blood passages around the valve compromising the normal flow of blood through the valve.", "Any surgical procedure around the valve may create such undesired leaks.", "Whether it is implantation of a prosthetic valve or procedures around the native heart valve, sutures or other means that must penetrate the surrounding tissue may be the source of such leaks.", "Leaks around the valve may also arise because of other undesired conditions.", "For example, after the replacement of the valve the pressure increases which could cause damages on the degenerated tissue around the valve area, such that leaks occur.", "That tissue can also be perforated with guide wires or guiding catheters during any other heart surgery procedure, with leaks as a consequence.", "In the case of prosthetic valves, over 210.000 valve replacements are performed each year world wide.", "In between 3-12% of the operations there is paravalvular leakage, and 3-4% is critical and needs reoperation.", "The diagnosis of paravalvular leak is done during the first year of the implantation.", "The patient may have a small PVL that may not effect the blood transfusion but can be diagnosed with imaging techniques such as TEE.", "Usually surgical therapy is the standard for treating paravalvular leaks but reoperation increases mortality and morbidity as compared to the first operation, i.e.", "reoperation is more difficult and increases the risk factor.", "After surgical reoperations 20% of the patients has residual or recurrent paravalvular leak.", "Another possibility is to use medical therapy, which is palative, i.e.", "the symptoms can be decreased but hemodynamic anomalies can not be regulated.", "Occlusion devices exist that are used for treating PVL.", "FIGS.", "1 a - b shows such occlusion device when positioned at the periphery of the prosthetic valve from an atrial view ( FIG.", "1 a ) and from a ventricular view ( FIG.", "1 b ).", "The occlusion device has portions positioned on either side of the valve.", "A problem with such previous occlusion devices is the disruption of the blood flow they create.", "Disruption of the blood flow is increasing risks for the patient for other complications and is detrimental to patient safety.", "The disruption can cause turbulence in the blood flow, which could increase the risks of embolies.", "A further problem is the insufficient sealing that previous occlusion devices provide.", "Insufficient sealing may lead to further reoperations and unnecessary complications for the patient.", "Another problem with the previous occlusion devices is the inability to adapt to the irregular and varying anatomy of the implantation site.", "Conformation to varying anatomies is critical for secure deployment of the occlusion device, without having to risk dislodgement and/or insufficient sealing.", "A further problem with previous devices is problems with orientation and delivery of the device.", "Proper orientation is important for achieving the correct function of the device, and also for ease of the procedure.", "All aforementioned problems affect not only patient safety but also available resources in the health care system as each patient will take longer to treat.", "Patient risks of previous paravalvular leak closure devices and methods include embolization of the device, stroke, arythmia, perforation of the biological prosthetic valve, and dysfunction of the valve prosthesis.", "WO2008153872 discloses a device to be positioned on either side of the wall of a tubular blood vessel.", "Arcuate portions of the device conform to the tubular blood vessels surface.", "Hence, an improved implant would be advantageous and in particular allowing for increased patient safety, flexibility, and/or cost-effectiveness would be advantageous." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>Accordingly, embodiments of the present invention preferably seeks to mitigate, alleviate or eliminate one or more deficiencies, disadvantages or issues in the art, such as the above-identified, singly or in any combination by providing a device and a method according to the appended patent claims.", "Embodiments of the present invention may be well suited for the selective occlusion of a vessel, lumen, channel, hole, cavity, or the like.", "One particular example, without limitation, of such a condition is Para-Valvular Leak (PVL).", "Another example is a vessel, lumen, channel, hole or shunt, through which blood flows from one vessel to another vessel such as an Atrial Septal Defect (ASD) or a Ventricular Septal Defect (herein after VSD), or Patent Ductus Arteriosus (PDA).", "Other examples could be an Arterial Venous Fistula (AVF), Arterial Venous Malformation (AVM), a Patent Foramen Ovale (PFO).", "According to a first aspect of the invention a medical implantable occlusion device is provided comprising a fabric of at least one thread and a structural formation thereof having a collapsed and an expanded shape.", "The formation comprises a proximal and a distal portion, a longitudinal axis extending between the proximal and distal portion, and at least one of the proximal and distal portions comprises a peripheral edge having a first and a second radius of curvature in a direction substantially perpendicular to the longitudinal axis, and the first radius of curvature is different from the second radius of curvature.", "According to a second aspect of the invention a medical method of occluding an opening such as a PVL is provided, comprising providing a device according to the first aspect of the invention, inserting the device in a collapsed state into the opening, expanding and releasing the device in the opening, thus anchoring the device in the opening for occluding the latter by the device.", "Further embodiments of the invention are defined in the dependent claims, wherein features for the second and subsequent aspects of the invention are as for the first aspect mutatis mutandis.", "Some embodiments of the invention provide for unrestricted blood flow through a prosthetic or native heart valve.", "Some embodiments of the invention provide for flexible positioning of a medical implant to varying anatomical sites in a body of a human or animal.", "Some embodiments of the invention also provide for secure attachment of a medical implant in a patient's vascular system.", "Some embodiments of the invention provide for a medical implant that can be safely delivered and oriented at treatment site in a patient.", "It should be emphasized that the term “comprises/comprising” when used in this specification is taken to specify the presence of stated features, integers, steps or components but does not preclude the presence or addition of one or more other features, integers, steps, components or groups thereof." ], [ "RELATED APPLICATIONS This application is a continuation of U.S. patent application Ser.", "No.", "15/174,948 filed Jun.", "6, 2016 entitled Medical Implantable Occlusion Device, And Method For Implantation Thereof, which a continuation of U.S. patent application Ser.", "No.", "14/241,062 filed Feb. 25, 2014 entitled Medical Implantable Occlusion Device, And Method For Implantation Thereof (now U.S. Pat.", "No.", "9,375,209 issued Jun.", "28, 2016), which is the U.S. National Phase of and claims priority to International Patent Application No.", "PCT/EP2012/068760, International Filing Date Sep. 24, 2012, entitled Medical Implantable Occlusion Device, And Method For Implantation Thereof, which claims benefit of U.S.", "Provisional Application Ser.", "No.", "61/537,623, filed Sep. 22, 2011 entitled Medical Implantable Occlusion Device, And Method For Implantation Thereof; and European Application No.", "11182390.2, filed Sep. 22, 2011 entitled Medical Implantable Occlusion Device; all of which are incorporated herein by reference in their entireties.", "FIELD OF THE INVENTION This invention pertains in general to the field of medical implants.", "More particularly the invention relates to an intraluminally deliverable occlusion device for selective occlusion of a target site in a body lumen, such as the body's circulatory system, and more particularly for occlusion of paravalvular leaks, and method for implantation of such occlusion device.", "BACKGROUND OF THE INVENTION Various intravascular deliverable devices are used for treating specific conditions via access through body lumina, such as patient's circulatory system.", "The target site may for instance be an atrial or ventricular septum having a defective opening to be occluded, such as devices for treating septal defects and the like.", "In certain circumstances, it may be necessary to occlude a patient's lumen, vessel, chamber, channel, hole, or cavity such as to stop blood flow there through.", "One such condition known in the art is Para-Valvular Leak (PVL) which may occur in association with surgical implantation of prosthetic valves in the heart, and with interventional valve implantations in general, i.e.", "transcatheter aortic valve intervention (TAVI).", "When the prosthetic valve is fixed by sutures micro-holes are created where the sutures penetrate the tissue.", "These micro-holes can become dilated over time and grow larger and also merge together, thereby creating undesired blood passages around the valve compromising the normal flow of blood through the valve.", "Any surgical procedure around the valve may create such undesired leaks.", "Whether it is implantation of a prosthetic valve or procedures around the native heart valve, sutures or other means that must penetrate the surrounding tissue may be the source of such leaks.", "Leaks around the valve may also arise because of other undesired conditions.", "For example, after the replacement of the valve the pressure increases which could cause damages on the degenerated tissue around the valve area, such that leaks occur.", "That tissue can also be perforated with guide wires or guiding catheters during any other heart surgery procedure, with leaks as a consequence.", "In the case of prosthetic valves, over 210.000 valve replacements are performed each year world wide.", "In between 3-12% of the operations there is paravalvular leakage, and 3-4% is critical and needs reoperation.", "The diagnosis of paravalvular leak is done during the first year of the implantation.", "The patient may have a small PVL that may not effect the blood transfusion but can be diagnosed with imaging techniques such as TEE.", "Usually surgical therapy is the standard for treating paravalvular leaks but reoperation increases mortality and morbidity as compared to the first operation, i.e.", "reoperation is more difficult and increases the risk factor.", "After surgical reoperations 20% of the patients has residual or recurrent paravalvular leak.", "Another possibility is to use medical therapy, which is palative, i.e.", "the symptoms can be decreased but hemodynamic anomalies can not be regulated.", "Occlusion devices exist that are used for treating PVL.", "FIGS.", "1a-b shows such occlusion device when positioned at the periphery of the prosthetic valve from an atrial view (FIG.", "1a) and from a ventricular view (FIG.", "1b).", "The occlusion device has portions positioned on either side of the valve.", "A problem with such previous occlusion devices is the disruption of the blood flow they create.", "Disruption of the blood flow is increasing risks for the patient for other complications and is detrimental to patient safety.", "The disruption can cause turbulence in the blood flow, which could increase the risks of embolies.", "A further problem is the insufficient sealing that previous occlusion devices provide.", "Insufficient sealing may lead to further reoperations and unnecessary complications for the patient.", "Another problem with the previous occlusion devices is the inability to adapt to the irregular and varying anatomy of the implantation site.", "Conformation to varying anatomies is critical for secure deployment of the occlusion device, without having to risk dislodgement and/or insufficient sealing.", "A further problem with previous devices is problems with orientation and delivery of the device.", "Proper orientation is important for achieving the correct function of the device, and also for ease of the procedure.", "All aforementioned problems affect not only patient safety but also available resources in the health care system as each patient will take longer to treat.", "Patient risks of previous paravalvular leak closure devices and methods include embolization of the device, stroke, arythmia, perforation of the biological prosthetic valve, and dysfunction of the valve prosthesis.", "WO2008153872 discloses a device to be positioned on either side of the wall of a tubular blood vessel.", "Arcuate portions of the device conform to the tubular blood vessels surface.", "Hence, an improved implant would be advantageous and in particular allowing for increased patient safety, flexibility, and/or cost-effectiveness would be advantageous.", "SUMMARY OF THE INVENTION Accordingly, embodiments of the present invention preferably seeks to mitigate, alleviate or eliminate one or more deficiencies, disadvantages or issues in the art, such as the above-identified, singly or in any combination by providing a device and a method according to the appended patent claims.", "Embodiments of the present invention may be well suited for the selective occlusion of a vessel, lumen, channel, hole, cavity, or the like.", "One particular example, without limitation, of such a condition is Para-Valvular Leak (PVL).", "Another example is a vessel, lumen, channel, hole or shunt, through which blood flows from one vessel to another vessel such as an Atrial Septal Defect (ASD) or a Ventricular Septal Defect (herein after VSD), or Patent Ductus Arteriosus (PDA).", "Other examples could be an Arterial Venous Fistula (AVF), Arterial Venous Malformation (AVM), a Patent Foramen Ovale (PFO).", "According to a first aspect of the invention a medical implantable occlusion device is provided comprising a fabric of at least one thread and a structural formation thereof having a collapsed and an expanded shape.", "The formation comprises a proximal and a distal portion, a longitudinal axis extending between the proximal and distal portion, and at least one of the proximal and distal portions comprises a peripheral edge having a first and a second radius of curvature in a direction substantially perpendicular to the longitudinal axis, and the first radius of curvature is different from the second radius of curvature.", "According to a second aspect of the invention a medical method of occluding an opening such as a PVL is provided, comprising providing a device according to the first aspect of the invention, inserting the device in a collapsed state into the opening, expanding and releasing the device in the opening, thus anchoring the device in the opening for occluding the latter by the device.", "Further embodiments of the invention are defined in the dependent claims, wherein features for the second and subsequent aspects of the invention are as for the first aspect mutatis mutandis.", "Some embodiments of the invention provide for unrestricted blood flow through a prosthetic or native heart valve.", "Some embodiments of the invention provide for flexible positioning of a medical implant to varying anatomical sites in a body of a human or animal.", "Some embodiments of the invention also provide for secure attachment of a medical implant in a patient's vascular system.", "Some embodiments of the invention provide for a medical implant that can be safely delivered and oriented at treatment site in a patient.", "It should be emphasized that the term “comprises/comprising” when used in this specification is taken to specify the presence of stated features, integers, steps or components but does not preclude the presence or addition of one or more other features, integers, steps, components or groups thereof.", "BRIEF DESCRIPTION OF THE DRAWINGS These and other aspects, features and advantages of which embodiments of the invention are capable of will be apparent and elucidated from the following description of embodiments of the present invention, reference being made to the accompanying drawings, in which FIGS.", "1a-b shows a medical implantable occlusion device according to prior art; FIG.", "2 is an illustration of a medical implantable occlusion device according to an embodiment of the invention; FIGS.", "3a-c are side views along cross-section a (CS) of the medical implantable occlusion device in FIG.", "2; FIG.", "4 is an illustration of a medical implantable occlusion device according to an embodiment of the invention; FIGS.", "5a-c are illustrations of a medical implantable occlusion device according to an embodiment of the invention; FIG.", "6 is an illustration of a medical implantable occlusion device according to an embodiment of the invention when implanted at a treatment site; FIGS.", "7a-d are illustrations of a medical implantable occlusion device according to an embodiment of the invention; FIG.", "8 is an illustration of a medical implantable occlusion device according to an embodiment of the invention; FIG.", "9 is a flow chart illustrating a method of occluding a PVL in a body lumen with a medical implantable occlusion device according to an embodiment of the invention; and FIGS.", "10a-c are illustrations of a medical implantable occlusion device according to an embodiment of the invention, shown in top-down view (a), and side views (b)-(c), respectively.", "DESCRIPTION OF EMBODIMENTS Specific embodiments of the invention will now be described with reference to the accompanying drawings.", "This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.", "The terminology used in the detailed description of the embodiments illustrated in the accompanying drawings is not intended to be limiting of the invention.", "In the drawings, like numbers refer to like elements.", "The following description focuses on an embodiment of the present invention applicable to a Para-Valvular Leak device (PLD).", "However, it will be appreciated that the invention is not limited to this application but may be applied to any other purposes of cardiac or vascular occlusion, and many other medical implantable devices, including for example filters, stents, Left Atrial Appendage (LAA) occluders, aneurysm treatment devices, grafts, etc.", "FIG.", "1 shows a medical implantable occlusion device 100 according to an embodiment of the invention.", "FIG.", "4 shows a device 200 in another embodiment of the invention, which is similar to the device 100 in FIG.", "1 but with other relative dimensions.", "The device 100, 200, comprises a fabric, mesh or braiding of at least one thread 101.The fabric may be formed from one thread or several.", "FIGS.", "3a-c are cross-sections of the device 100, 200, along the line CS in FIG.", "1 or FIG.", "4, which will be discussed in further detail below.", "The device 100, 200, or more particularly the structural formation 102 of the fabric of threads 101, has an unloaded expanded shape and a collapsed shape.", "Thus, in the expanded shape, wherein the device 100 has a shape as depicted in FIG.", "1 and FIG.", "2, no external force acts on the device 100, 200.The device 100, 200, may be stretched and thereby exhibit a smaller cross-section, in order to fit inside a delivery device such as a catheter.", "The device 100, 200, may be self-expandable between the collapsed shape and the expanded shape, i.e.", "when the device 100, 200, is removed from the confinement of the catheter the cross-section of the device 100, 200, returns to its originally defined value in the unloaded expanded shape.", "The device may be self-expandable due to an inherent elasticity of the threads in the fabric or braiding.", "The device may also have a shape memory, e.g.", "triggerable to go to the expanded shape at a switching temperature, such as body temperature.", "The shape of the device 100, 200, in the expanded shape may be defined in a heat treatment procedure of the device 100, 200, or more particularly of the braiding of the device.", "The dimensions of the device 100, 200, in the expanded, relaxed, shape are defined in the heat treatment procedure of the braiding.", "The entire device 100, 200, may be comprised of a single, continuous fabric or braiding.", "The braiding may be made of a material suitable for implanting in a human or animal body, and suitable for being formed in a heat treatment procedure to a desired shape in the expanded shape and also in the stretched state.", "For example NiTinol may be used as a material for the device 100, 200.However, suitable materials for embodiments of the braiding are various and include shape memory materials, metal, superelastic alloys (such as NiTinol), or polymers, such as degradable polymers.", "The structural formation 102 of the device 100, 200, comprises a proximal portion 103, and a distal portion 104.A longitudinal axis 105 extends between the proximal and the distal portion, which is best illustrated in FIG.", "3a.", "In FIG.", "3a it is also seen that the proximal, and distal portions 103, 104, may comprise expanded diameter portions 103, 104, that are separated by a waist 106 of reduced cross-section between the proximal and distal portions 103, 104.The length 120 of the waist 106 may correspond substantially to the wall thickness of the defect to be occluded, when the proximal and distal portions 103, 104, are positioned on either side of such defect.", "The flexible nature of the at least one thread 101 of the device 100, 200, however allows the device to adapt to a wide range defect dimensions.", "The proximal and distal portions 103, 104, will strive in a direction towards each other to the expanded shape when separated by the defect, thereby closing against the walls on either side of the defect and providing the occluding effect.", "The width 121 of the waist 106 may approximate the width of the defect, i.e.", "the width of the opening of the paravalvular leak defect.", "FIGS.", "10b and 10c show two different types of waists 106, along the cross-section A of the device 100 seen in a top-down view in FIG.", "10a.", "According to one embodiment the waist may comprise narrowly or tightly twisted threads 101, of the fabric or braiding of the device 100, around the longitudinal axis 105, in order to produce a waist 106 of small cross-section relative to the diameter of the proximal and distal portions 103, 104.This small cross-section allows for fitting of the device in small openings to be occluded.", "During manufacturing of the device 100, the proximal and distal portions 103, 104, may be twisted in relation to each other around the longitudinal axis 105, during a heat setting step, to produce a waist 106 with twisted threads 101.This may be part of a subsequent heat setting step, after a first heat setting step for forming the expanded diameter portions, i.e.", "the proximal and distal portions 103, 104, and the reduced diameter portion, i.e.", "the waist.", "Alternatively, the twisting is made during the same first heat setting step.", "The waist 106 may be made of a portion of parallel threads or a more densely braided section of the fabric at the waist 106, providing for particular strength in the longitudinal direction.", "The waist 106 may be arranged concentrically with respect to the proximal and distal portions 103, 104, but an asymmetric configuration may be suitable in particular anatomies to be occluded.", "At least one of the proximal and distal portions 103, 104, comprises a peripheral edge 107, 108, having a first 109, 109′, and a second 110, 110′, radius of curvature in a direction substantially perpendicular to the longitudinal axis 105.The first radius of curvature 109, 109′, is different from the second radius of curvature 110, 110′.", "In this way the peripheral edge 107, 108, may conform to various anatomical geometries neighboring the defect to be occluded, hence avoiding unnecessary blockage and disruption of e.g.", "blood flow, while still providing the occlusion of the defect.", "In case of paravalvular leak defects (PVL) the at least one of the first and second radius of curvatures may be chosen such that the curvature of at least a section of the peripheral edge 107, 108, corresponds substantially to a valve curvature 116 of a valve 115 for regulating blood flow.", "This is illustrated in FIG.", "6, where the device 200 occludes a PVL close to the outer boundary of the valve 116.The device 200 has a peripheral edge 108 with a second radius of curvature 110′ that corresponds substantially to the valve curvature 115.The first radius of curvature 109′ as exemplified in FIG.", "6 is different from the second radius of curvature 110′ of the peripheral edge 108, and the peripheral edge 108 may have any shape to conform to varying neighboring geometries where the influence of the occlusion device must be minimized while providing the necessary occlusion effect.", "A prior art device 10 is shown in FIGS.", "1a-b, which is a typical example of the influence such prior art devices have on the prosthetic valve because of its substantial blockage of the valve 115 when positioned in a PVL at the periphery of the valve 20.FIG.", "1a is a view from the atrial side, and FIG.", "1b is a view from the ventricular side, where the latter most clearly shows the device 10 extending over a substantial portion of the valve 20.Such device 10 may disrupt the blood flow, create turbulence and lead to various complications as discussed above.", "Returning to FIG.", "6, the corresponding overreach across the valve 115 resulting from such prior art devices is marked with dashed line 121.The varying radius of curvature 109′, 110′, of the device 100, 200, allows occlusion of PVL close to the valve 115 without any overreach across the valve and the associated complications.", "FIGS.", "5a-c illustrates the amount of area that is saved by the device 100, 200, which otherwise would have negative impact.", "FIG.", "5a shows the coverage by a prior art device 10 (dashed lines), and FIG.", "5b shows the coverage by the device 200, while FIG.", "5c shows the differential area 122 that is saved which will not block the flow of blood through the valve 115.Both the proximal and distal portions 103, 104, may have peripheral edges 107, 108, with varying radius of curvature.", "FIG.", "2 shows the first and second radius of curvature 109, 110, for the proximal portion 103, and the first and second radius of curvature 109′, 110′, of the distal portion 104 for the device 100.FIGS.", "4 and 6 shows a similar configuration for the device 200.In this way the blood flow will not be disrupted on any side of the valve 115.The dimensions of the device 100, 200, such as indicated in FIGS.", "2 and 3, c.f.", "A, A′, B, B′, C, C′, C″, C′″, D, E, may be adapted such that proper alignment of the device 100, 200, to the valve curvature 116 is achieved.", "As seen in FIGS.", "2, 4, 5, 6, the peripheral edge 107, 108, is concave radially outwards.", "I.e.", "in a direction substantially perpendicular to the longitudinal axis 105, FIG.", "3a.", "This allows the peripheral edge 107, 108, to follow the convex shape of the valve curvature 116, so that no overlapping of the valve 115 occurs.", "The radius of curvature of the concave part can be varied as desired in order to achieve the closest correspondence with the valve curvature 116.The number of concave sections of the peripheral edge 107, 108, may vary.", "The devices 100, 200, in FIGS.", "2, 4, 5, 6, have four concave sections, but it could be one, two, three, five or more.", "Leaks can occur around the valve 115 at a 360 deg location.", "The curvature of the peripheral edge 107, 108, may be sized and shaped to cover several PVL's around the valve curvature 116.Due to the varying radius of curvature or the concave peripheral edge 107, 108, several PVL's may be occluded with a single device 100, 200, without extending across the valve 115 and disturbing the blood flow.", "As further shown, e.g.", "in FIG.", "2, the peripheral edge 107, 108, comprises edge sections 112, 112′, 113, 113′, that are alternatingly concave and convex radially outwards in a direction substantially perpendicular to the longitudinal axis 105.Each of the concave edge sections 112, 112′, also seen in FIG.", "4 and denoted 114, 114′, may be positioned against the valve curvature 116.The devices 100, 200, have the convex sections 113, 113′, positioned in between the concave sections 112, 112′, which results from having a several concave sections.", "The geometric terms concave and convex as used herein is to be interpreted for the purposes of the invention as their normal geometrical meaning including any recesses in the device for the purpose of the term concave and protrusions of the device for the purposes of the term convex, where such recesses and protrusions may also define the spatial extent of the device 100, 200, i.e.", "the peripheral edge 107, 108, such that the device 100, 200, may follow the valve curvature 116.The peripheral edge 107, 108, may be continuous without sharp interruptions, kinks or corners, as illustrated in the Figures, or comprise discontinuous sections.", "The device 100, 200, has radially opposed edge sections 112, 112′, 114, 114′, of the peripheral edge 107, 108, that have substantially the same radius of curvature, e.g.", "as seen in FIGS.", "2 and 4.Such symmetry may provide ease of positioning against the valve curvature 116.In FIG.", "2, the device 100, has substantially the same radius of curvature for all concave sections of the peripheral edge 107, 108.Alternatively, the device 100, 200, may comprise concave edge sections having different radius of curvatures 109, 109′, 110, 110′, which allows the device 100, 200, to conform to a wide range of valves 115, having different valve curvatures 116.FIG.", "4 shows a device 200 having first radially opposed edge sections 112, 112′, of the peripheral edge 107, 108, having a radius of curvature that is larger than the radius of curvature of second radially opposed edge sections 114, 114′.", "As mentioned above this may provide selectivity to various geometries of the valve 115.By simply rotating the device 200, the physician may select one peripheral edge with a particular radius of curvature that conforms best to the valve curvature 116, and/or the opening to be occluded.", "Also, the device 200 may provide increased holding strength against the defect to be occluded by its increased radial extent along a first axis, while maintaining the limited radial extent along a second axis, being perpendicular to the first axis, i.e.", "the second axis extending in direction across the valve 115.Overlap across the valve 115 by the device 200 (along the aforementioned second axis) is thereby avoided, while increased holding strength is provided.", "The peripheral edge may comprise at least two edge sections 112, 112′, or 114, 114′, that are concave radially outwards in a direction substantially perpendicular to said longitudinal axis.", "Having more than one concave edge may allow selectivity as described above, and/or ease of positioning if the edges have similar radius of curvature.", "Further, by having a rotational symmetric device 100, 200, around axis 105, the ease of handling and insertion, and also stability and structural integrity of the device can be increased.", "This can be realized by having two radially opposed concave edges as described above.", "The radius of curvature of the peripheral edge 107, 108, may correspond to a particular defect to be occluded and/or the curvature of the valve.", "The device 100, 200, may have a peripheral edge 107, 108, that defines a generally rectangular shape of the proximal or distal portion 103, 104.As seen in FIGS.", "2 and 4, the device 100, 200, has four convex corners, see e.g.", "edge sections 113, 113′, and concave sections in between, 112, 112′.", "The peripheral edge 107, 108, may have a radius of curvature that vary considerably, e.g.", "the convex corners 113, 113′, of the device 100, 200, may be in the form of a sharp transition from one concave edge section to the next, as alternative to a smooth continuous transition.", "In either case the device 100, 200, may be referred to as having a generally rectangular shape due to having four corners in the Figs.", "As mentioned above the number of concave sections 112, 112′, and corners, i.e.", "convex sections 113, 113′ may vary, and the device 100, 200, may have generally triangular, pentagonal shapes etc, as long as the peripheral edge 107, 108, has at least a section of its curvature that can be positioned close to the valve curvature 116 without extending across the valve 115, when the device 100, 200, is in its implanted site.", "At least one of the proximal and distal portions 103, 104, may be deflected towards the other portion with an angle V, V′.", "In this way the device 100, 200, may better accommodate to the anatomy at the implanted site and thereby provide a closer fit against the tissue by the proximal and/or distal portion 103, 104, for improved occlusion.", "For example, at the periphery of the valve 115, there is often a “volcano crest”, i.e.", "a protrusion going around the periphery.", "When the proximal or distal portion 103, 104, is positioned close to that protrusion the deflection of the aforementioned portions towards each other with angle, V, V′, allows these portions to reach over the protrusion and down to the tissue nest to the protrusion for a secure fit.", "FIG.", "3a shows the cross-section of the device 100, 200, where the proximal portion 103 is deflected towards the distal portion 104 with an angle V, and the distal portion 104 is deflected towards the proximal portion 103 with an angle V′.", "The angles V and V′ may be substantially the same or different depending on the anatomy of the site in the vascular system to be occluded.", "E.g.", "the distances 123, 124, as indicated in FIG.", "3a, may be varied.", "Only one of the portions 103, 104, may be angled towards the other.", "The device 100, 200, may thereby be adapted to the irregular and varying anatomy of the implantation site.", "This also allows for a particular stable long-term construction even in anatomical situations where a continuous movement at the implantation site is present.", "One of the proximal and distal portions 103, 104, may have a larger diameter than the other portion, thereby creating an overlap 117 between the proximal and distal portions 103, 104.The overlap may provide increased sealing ability of the device 100, 200, e.g.", "when the portions 103, 104, being pressed towards each other.", "The overlap may substantially be in the radial direction, perpendicular to longitudinal axis 105.As seen in FIG.", "3a, the distal portion 104 overlaps the proximal portion 103 in the radial direction, which is also seen in e.g.", "FIG.", "2 with respect to peripheral edges 107, 108.When the distal portion 104 is placed on the side of the defect being exposed to high pressure, e.g.", "on the ventricular side of the heart (depending on which valve that has PVL; Aortic, Mitral, Tricuspid, or Pulmonary), the larger area of the distal portion 104 will improve the sealing against the tissue, while the smaller area of the proximal portion minimizes overlap across the valve 115.Thus a secure occlusion is achieved even before the device 100, 200, is securely covered with endothelia and tissue integrated with the surrounding tissue.", "The diameter may be equivalent to the largest cross-section throughout the disclosure.", "The proximal and distal portions 103, 104, may be substantially flat and having a diameter larger than the opening of the PVL which it is placed.", "FIGS.", "7a-d shows perspective view of the device 100, 200, i.e.", "FIG.", "7a is a tilted side view, FIG.", "7b is a side view, FIG.", "7c is a top-down view facing the proximal portion 103, and FIG.", "7d is a top-down view facing the distal portion 104.Even though the device in FIGS.", "7a-d more closely reassembles the device 100 in FIG.", "2 due to having substantially sides of equal length, the perspective views in the Figs.", "is also representative of the device 200 in FIG.", "4.The device 100, 200, may comprise at least one a marker element 118, 118′, for aiding in orienting the device 100, 200.Such marker 118, 118′, allows identification of the device and reassurance that the device has been implanted correctly.", "For example, it can be determined whether the concave edge section 112 of the peripheral edge 107, 108, has been aligned against the valve curvature 116.Thus, the at least one marker element 118, 118′, may be arranged on one of the proximal and distal portions 103, 104, at a position corresponding substantially to the location of the peripheral edge 107, 108.FIG.", "8 illustrates the location of two markers 118, 118′, which are close to the peripheral edge 107 of the proximal portion 103.The markers 118, 118′, may be arranged on opposite concave sections, as illustrated in the figure for allowing correct positioning.", "The markers 118, 118′, may be attached to the proximal portion 103, or to the distal portion 104.Hence, the markers 118, 118′, in FIG.", "8 could be attached to the distal portion 104, for marking out the position of the peripheral edge 107 of the proximal portion 103.As the distal portion 104 may have increased diameter or circumference, the markers 118, 118′, could be attached to the distal portion 104 at a distance from the peripheral edge 108 of the distal portion 104, while still marking out the peripheral edge 107 of the proximal portion.", "This may allow for easier attachment of the markers 118, 118′, to the device 100, 200, and less interference with the operation of the device 100, 200, as the markers do not have to be attached to the proximal peripheral edge 107, while still allowing exact positioning with respect to the valve curvature 116 with the proximal peripheral edge 107.The marker element 118 may comprise a radiopaque material, hence being identifiable in X-ray, or comprise material for easy identification in MRI.", "The device 100, 200, may comprise two markers 118 as shown in FIG.", "7d, arranged across the radial direction of the distal portion 104, and/or alternatively of the proximal portion 103.Any number of markers 118 may be used for identification.", "The markers 118 may be fixated to an occluding element such as a patch, fibers or the like comprising a biocompatible material (e.g.", "PET) for supporting the sealing of the blood flow through the device 100, 200, or fixed to the fabric of threads 101 of the device 100, 200, itself.", "As shown in FIGS.", "3b, 3c and FIGS.", "7a-c, the device 100, 200, may comprise a connecting member 111 attached to one of the distal and proximal portions 103, 104, for connection to a delivery device (not shown).", "The delivery device may grasp the connection member 111 which may be spherical in shape, thus providing a pivoting motion of the device 100, 200, in relation to the delivery device in combination with secure attachment.", "The connection member 111 may be arranged on the proximal portion 103 as shown in FIG.", "3b, or on the distal portion 104 as shown in FIG.", "3c.", "FIG.", "7a-c illustrates the device 100, 200, having the connection member 111 on the proximal portion 103.In reality the portion having the connection member 111 becomes the proximal portion in use of the device, but the above conventions are used for conciseness in the description and figures.", "Hence, the connection member 111 may be arranged on the expanded diameter portion 104, or the increased diameter portion 104.This allows the possibility to access the PVL from both sides of the leak.", "The connecting member 111 may be configured for connection to a delivery device in a predetermined orientation.", "Hence a specific orientation of the device 100, 200, could be maintained relative to the delivery device during implantation which may aid in positioning the device 100, 200, in relation to the valve curvature 116.The ends of the at least one thread 101 forming the fabric may be fixed to the connecting member 111.The connecting member 111 may thus be a weld or any other attachment means for the threads 101 of the fabric.", "The distal portion 104 may comprise returning loops 119 of the at least one thread 101, meaning that opposite ends of the at least one thread 101 forming the distal portion 104 are fixed to the connecting member 111.By having returning loops only one collection point for the ends of the at least one thread 101 is needed.", "The connection member 111 may thus serve as a connection for these ends, thereby avoiding multiple connection points such as welds on the distal portion 104.Hence, a flat distal portion 104 may be provided, that increases the compactness of the device 100, 200.The flat distal portion 104 may thus be a closed continuous distal wall 301 of the braiding forming the device 100, 200, i.e.", "free from a thread ends.", "This reduces the risk thromboembolic complications.", "E.g.", "nothing is protruding into the blood stream, and there are no discontinuities that may cause thromboembolic complications.", "Further, due to the connection member 111 on the proximal end 103, the device 100, 200, may be delivered through the vena cava with improved safety to the patient.", "The implantation techniques are different for each PVL according to the valve and the location of the leak.", "Delivery to the high pressure arterial side of the vascular system is avoided, which provides for less complications and a medical procedure which is simpler to perform.", "FIG.", "9 illustrates a medical method 900 of occluding an opening in a body lumen, comprising providing 901 a device 100, 200, inserting 902 the device 100, 200 in a collapsed state into the opening, expanding 903 and releasing the device 100, 200, in the opening, thus anchoring 904 the device 100, 200, in the opening for occluding the latter by the device 100, 200.The opening may be a Para-Valvular Leak (PVL), and the method may comprise positioning 905, or rotating, the device 100, 200, such that a concave edge section 112, 112′ of the device 100, 200, substantially follows the valve curvature 116 of the valve 115.The present invention has been described above with reference to specific embodiments.", "However, other embodiments than the above described are equally possible within the scope of the invention.", "The different features and steps of the invention may be combined in other combinations than those described.", "The scope of the invention is only limited by the appended patent claims.", "More generally, those skilled in the art will readily appreciate that all parameters, dimensions, materials, and configurations described herein are meant to be exemplary and that the actual parameters, dimensions, materials, and/or configurations will depend upon the specific application or applications for which the teachings of the present invention is/are used." ] ]
Patent_15872908
[ [ "NANOWIRE AND MICROWIRE FABRICATION TECHNIQUE AND PRODUCT", "A continuous or semi-continuous process for fabricating nanowires or microwires makes use of the substantially planar template that may be moved through electrochemical solution to grow nanowires or microwires on exposed conductive edges on the surface of that template.", "The planar template allows fabrication of the template using standard equipment and techniques.", "Adhesive transfer may be used to remove the wires from the template and in one embodiment to draw a continuous wire from the template to be wound around the drum." ], [ "1.-13.", "(canceled) 14.A method of fabricating wire comprising the steps of: moving a template through a chamber of electrochemical solution; interacting an electrically conductive edge of the template with the electrochemical solution; applying an electrical power source between the electrochemical solution in the chamber and the electrically conductive edge of the structure; forming a wire on the electrically conductive edge interacting with the electrochemical solution; and removing the formed wires with a transfer element.", "15.The method of claim 14 wherein the electrically conductive edge defines at least one substantially continuous circle on the planar template centered about an axis and wherein a first portion of the electrically conductive edge interacts with the electrochemical solution while a second portion of electrically conductive edge does not interact with the electrochemical solution such that the removal of the formed wire with the transfer element is from the second portion to by transfer to a spool.", "16.The method of claim 15 wherein the template is mounted for rotation about a first axis perpendicular to the surface of the template and further including a disk having an edge contacting the surface of the template and following an annular track on the surface of the template concentric about the first axis on the template with mutual rotation of the transfer element and template, and wherein the spool is a drum and wherein the step of transferring the wire formed on the electrically conductive edge, first transfers the continuous wire from the template to the disk and second transfers the continuous wire from the disk to the drum to spool wire received from the transfer element in a helical coil along a surface of the drum.", "17.The method of claim 16 wherein the disk and the drum are coated with adhesive and wherein the adhesive on the drum has a greater adhesion to the wire than the adhesive on the disk.", "18.The method of claim 17 including the step of passing the disk through a releasing liquid with rotation of the disk about the second axis.", "19.The method of claim 14 wherein the transfer element is a flexible tape having an adhesive surface and pressed against a surface of the template by a guide to follow an annular track on the surface of the template concentric about an axis of rotation of the template with rotation of the template.", "20.The method of claim 14 further including the step of using an electronic computer executing a stored program to control a parameter selected from the group consisting of: (a) a rate of rotation of the template through the electrochemical solution; (b) an applied voltage across the electrodes; and (c) the composition of the electrochemical solution.", "21.A template for growing nanowires or microwires comprising: an insulating layer providing a substrate; a pattern of conductor positioned over the insulating layer providing edges at desired locations of wires; and a second insulating layer covering the pattern of conductor except at the edges and without overhang of the edges of the conductor by the insulating layer along a direction normal to a surface of the substrate at the edges; and wherein the insulating layers and conductor are selected to permit physical detachment of wires grown thereon by cohesive forces without substantial damage to the insulating layers and conductor; wherein the edges of the pattern conductor form an obtuse angle with respect to a surface of the substrate.", "22.A method of fabricating wire comprising the steps of: moving a template through a chamber of electrochemical solution, the substantially planar template having a surface and a conductive layer with an electrically conductive ultranano crystalline diamond edge formed in a predefined pattern, the template mounted for rotation about a first axis perpendicular to the surface; immersing at least a portion of the electrically conductive edge of the template in the electrochemical solution; applying an electrical power source between the electrochemical solution in the chamber and the electrically conductive edge of the structure; forming a wire on the electrically conductive edge interacting with the electrochemical solution; and removing the formed wires with a transfer element.", "23.The method of claim 22, wherein the template is substantially planar.", "24.The method of claim 22, wherein removing the formed wires comprises, interacting a chamfered edge of the transfer element with the surface; parallel to the surface, the chamfered edge having an adhesive surface and mounted for movement with respect to the template and contact with the template; and removing from the template at least a portion of the wire grown by electrochemical action on the structure of the template.", "25.The method of claim 23, wherein the chamfered edge and the surface are parallel when interacted 26.The method of claim 22, further comprising rotating the transfer element about a second axis angled with respect to the first axis, wherein the chamfered edge contacts the surface of the template and following an annular track on the surface of the template concentric about the first axis on the template with mutual rotation of the transfer element and template.", "27.The method of claim 26, further comprising rotating a drum about a third axis and contacting a drum adhesive surface and the chamfered edge to pull wires off of the transfer element with rotating contact between the drum and transfer element.", "28.The method of claim 27, further comprising spooling a wire received from the transfer element into a helical coil along a surface of the drum.", "29.The method of claim 28, further comprising immersing at least a portion of the transfer element chamfered edge in a second chamber having a releasing liquid." ], [ "<SOH> BACKGROUND OF THE INVENTION <EOH>Conductive, semi-conductive, and insulating nanowires hold great promise for the creation of new devices including small-scale electrical circuit elements, sensors, and the like.", "Of particular interest in this regard are metallic nanowires.", "The creation of relatively long molybdenum nanowires is described in a paper authored by the present inventor and published in Science 2001, 290, (5499), 2120-2123 hereby incorporated by reference.", "This particular fabrication technique employed highly oriented pyrolytic graphite (HOPG) as a substrate.", "Nanowires were formed through electrochemical step edged decoration (ESED) techniques in which edges on a terraced surface of the HOPG provided a deposition site for the electrochemically deposited nanowires following those edges.", "Fabricating devices from nanoconductors can be difficult.", "In the above ESED technique, the produced nanowires have irregular orientation resulting from the difficulty of controlling the geometry of the step edges on the HOPG substrate.", "These variations also affect, to a lesser degree, the diameter of the wires produced.", "Production of the nanowires is further hampered by the fragile nature and expense of the HOPG.", "HOPG also contains numerous defects that result in particles forming in between the wires.", "Nanowires have been fabricated by using a pocket fouled under a layer of photoresist between the photoresist and a substrate as separated by a nanothickness layer of nickel.", "See “Lithographically Patterned Nanowire Electrodeposition”, E. J. Menke et al., Nature Materials 5, 914-919 (2006).", "This technique makes use of an edge of a larger pattern to define the location of the nanowire eliminating a need for nanoscale line widths in generating the pattern.", "U.S. patent application Ser.", "No.", "12/358,801, filed Jan. 23, 2009 and assigned to the same assignee as the present invention, describes a system for making nanowires that employs a robust template of ultrananocrystalline diamond that allows for the electrochemical formation of wires along an edge of conductive diamond and that resists damage over multiple reuses in which the wires pulled from the diamond edge.", "A continuous or semi continuous process is described in which the template is formed in a drum that may be rotated in through immersion in electrochemical solution." ], [ "<SOH> SUMMARY OF THE INVENTION <EOH>The present invention provides an improved method and apparatus for continuous or semi continuous electrochemical wire or wire-shape formation using a flat template.", "By using a flat template the need for drum, which can be difficult to fabricate, is avoided.", "In one embodiment, the template is patterned to provide a substantially continuous wire formed over many rotations of the template through electrochemical solution.", "An adhesive transfer wheel may remove the wire and transfer it to a spooling system.", "Specifically then, the present invention provides an apparatus for fabricating wire having a chamber for retaining a volume of electrochemical solution and having a substantially planar template.", "The template provides a surface having structure presenting an electrically conductive edge formed in a predefined pattern and is mounted for movement with respect to the chamber to partially immerse the template in an electrochemical solution in the chamber and to change a portion of the template so immersed with movement of the template with respect to the chamber.", "A transfer element provides an adhesive surface and is mounted for movement with respect to the template to pull wires grown by electrochemical action on the structure of the template off of the structure of the template, after contact and separation between the structure and the surface of the transfer element.", "An electrical power source communicates between and electrode within the chamber connectable to an electrochemical solution in the chamber and a second electrode connecting to the electrically conductive edge of the structure.", "It is thus a feature of at least one embodiment of the invention to provide continuous or semi continuous manufacture of nanowires or microwires and wire shapes while avoiding the need for drum-shaped template, thus permitting manufacture of the template using standard integrated surface substrates, for example silicon wafers, and integrated circuit processing techniques, such as optical or electron beam lithography.", "The template may be mounted for rotation about a first axis perpendicular to the surface of the template and the transfer element may be a disk rotating about a second axis angled with respect to the first axis, the disk having an edge contacting the surface of the template and following an annular track on the surface of the template concentric about the first axis on the template with mutual rotation of the transfer element and template.", "In one implementation, multiple annular tracks are utilized and a stranded nanowire is formed.", "It is thus a feature of at least one embodiment of the invention to provide a simple of removing nanowires and microwires from the template on a continuous basis and in a manner compatible with cyclic immersions of the template in an electrochemical solution.", "The edge of the disk of the transfer element may be beveled to have a non-perpendicular angle with respect to the second axis.", "It is thus a feature of at least one embodiment of the invention to reduce the sheer and/or strain on the nanowirenanowires and microwires during removal by tipping the transfer wheel axis toward the axis of the template.", "The apparatus may include a drum rotating about a third axis and providing an adhesive surface and mounted for movement with respect to transfer element to pull wires off of the transfer element with rotating contact between the drum and transfer element.", "It is thus a feature of at least one embodiment of the invention to permit the transfer of arbitrarily long continuous wires from a finite sized template.", "The drum may translate along the third axis with respect to the transfer element and spool a wire received from the transfer element in a helical coil along a surface of the drum.", "It is thus a feature of at least one embodiment of the invention to provide an orderly winding of extremely long micro-wire or nanowire and to reduce damage thereto.", "The predefined pattern of the electrically conductive edge may define at least one substantially continuous circle on the planar template centered about the axis.", "It is thus a feature of at least one embodiment of the invention to permit a single wire to be formed by multiple rotations of the template through an electrochemical bath.", "By forming the wire along a continuous radius it may be removed tangentially with minimal bending.", "The apparatus may include second chamber for holding a releasing liquid and positioned to admit a portion of the transfer element to move through the releasing liquid with rotation of the transfer element about the second axis.", "In one implementation, the liquid aids in removal of the wire by replacing the wire polymer cohesive force with a liquid-polymer interaction that is stronger.", "It is thus a feature of at least one embodiment of the invention to provide a mechanism for releasing nanowires and microwires from an adhesive transfer element to allow the adhesive transfer element to be reused on a continuous or semi continuous basis.", "The second chamber may include an agitation element for agitating the releasing liquid.", "It is thus a feature of at least one embodiment of the invention to provide for the release of microwires or nanowires with reduced distortion and mechanical damage.", "The template may be mounted for rotation about a first axis perpendicular to the surface of the template.", "It is thus a feature of at least one embodiment of the invention to provide a simple method of cyclically immersing the template in an electrochemical solution as is required for continuous or semi continuous processing.", "The chamber may open upward to admit a portion of the template during rotation of the template with the surface of the template extending vertically.", "It is thus a feature of at least one embodiment of the invention to provide a simple method of providing different zones on the surface of the template allowing for both exposure of the template to electrochemical solution and a drying of the template in a cyclic fashion.", "The predefined pattern of the electrically conductive edge may alternately define multiple discontinuous elements positioned over the surface of the template.", "It is thus a feature of at least one embodiment of the invention to provide a similar mechanism for producing small wire shapes.", "In one embodiment the transfer element may be a flexible tape having an adhesive surface and pressed against a surface of the template by a guide to follow an annular track on the surface of the template concentric about the first axis on the template with rotation of the template.", "It is thus a feature of at least one embodiment of the invention to provide a transfer of small wire shapes to a carrier for later use or placement.", "The apparatus may include an electronic computer executing a stored program controlling operation of the apparatus selected from the group consisting of: (a) a rate of rotation of the substrate through the electrochemical solution; (b) an applied voltage across the electrodes; and (c) the composition of the electrochemical solution.", "It is thus a feature of at least one embodiment of the invention to provide a mechanism that may precisely controlled processing conditions, for example, through feedback or preprogram schedules for improved manufacturing efficiency or research.", "The electrically conductive edge on the planar template may be at an obtuse angle with respect to the substrate.", "It is thus a feature of at least one embodiment of the invention to provide for improved removal of electrochemically formed wires on the edge by tipping the edge in the direction of removal.", "These particular features and advantages may apply to only some embodiments falling within the claims and thus do not define the scope of the invention.", "Additional features, advantages, and embodiments of the present disclosure may be set forth from consideration of the following detailed description, drawings, and claims.", "Moreover, it is to be understood that both the foregoing summary of the present disclosure and the following detailed description are exemplary and intended to provide further explanation without further limiting the scope of the present disclosure claimed." ], [ "CROSS-REFERENCE TO RELATED APPLICATIONS This application claims priority from U.S.", "Provisional Application 61/675,227, filed Jul.", "24, 2012, and is incorporated herein by reference in its entirety.", "STATEMENT OF GOVERNMENT INTEREST The United States Government has rights in the invention described herein pursuant to Contract No.", "DE-AC02-06CH11357 between the United States Department of Energy and UChicago Argonne, LLC, as operator of Argonne National Laboratory.", "The United States Government may further have rights in the invention described herein pursuant to National Science Foundation grant 0954656.FIELD OF THE INVENTION The present invention relates generally to nanotechnology and in particular to a method of creating metallic and semiconducting nanowires, heterogeneous nanowires, and nanowire assemblies using a technique suitable for mass production.", "BACKGROUND OF THE INVENTION Conductive, semi-conductive, and insulating nanowires hold great promise for the creation of new devices including small-scale electrical circuit elements, sensors, and the like.", "Of particular interest in this regard are metallic nanowires.", "The creation of relatively long molybdenum nanowires is described in a paper authored by the present inventor and published in Science 2001, 290, (5499), 2120-2123 hereby incorporated by reference.", "This particular fabrication technique employed highly oriented pyrolytic graphite (HOPG) as a substrate.", "Nanowires were formed through electrochemical step edged decoration (ESED) techniques in which edges on a terraced surface of the HOPG provided a deposition site for the electrochemically deposited nanowires following those edges.", "Fabricating devices from nanoconductors can be difficult.", "In the above ESED technique, the produced nanowires have irregular orientation resulting from the difficulty of controlling the geometry of the step edges on the HOPG substrate.", "These variations also affect, to a lesser degree, the diameter of the wires produced.", "Production of the nanowires is further hampered by the fragile nature and expense of the HOPG.", "HOPG also contains numerous defects that result in particles forming in between the wires.", "Nanowires have been fabricated by using a pocket fouled under a layer of photoresist between the photoresist and a substrate as separated by a nanothickness layer of nickel.", "See “Lithographically Patterned Nanowire Electrodeposition”, E. J. Menke et al., Nature Materials 5, 914-919 (2006).", "This technique makes use of an edge of a larger pattern to define the location of the nanowire eliminating a need for nanoscale line widths in generating the pattern.", "U.S. patent application Ser.", "No.", "12/358,801, filed Jan. 23, 2009 and assigned to the same assignee as the present invention, describes a system for making nanowires that employs a robust template of ultrananocrystalline diamond that allows for the electrochemical formation of wires along an edge of conductive diamond and that resists damage over multiple reuses in which the wires pulled from the diamond edge.", "A continuous or semi continuous process is described in which the template is formed in a drum that may be rotated in through immersion in electrochemical solution.", "SUMMARY OF THE INVENTION The present invention provides an improved method and apparatus for continuous or semi continuous electrochemical wire or wire-shape formation using a flat template.", "By using a flat template the need for drum, which can be difficult to fabricate, is avoided.", "In one embodiment, the template is patterned to provide a substantially continuous wire formed over many rotations of the template through electrochemical solution.", "An adhesive transfer wheel may remove the wire and transfer it to a spooling system.", "Specifically then, the present invention provides an apparatus for fabricating wire having a chamber for retaining a volume of electrochemical solution and having a substantially planar template.", "The template provides a surface having structure presenting an electrically conductive edge formed in a predefined pattern and is mounted for movement with respect to the chamber to partially immerse the template in an electrochemical solution in the chamber and to change a portion of the template so immersed with movement of the template with respect to the chamber.", "A transfer element provides an adhesive surface and is mounted for movement with respect to the template to pull wires grown by electrochemical action on the structure of the template off of the structure of the template, after contact and separation between the structure and the surface of the transfer element.", "An electrical power source communicates between and electrode within the chamber connectable to an electrochemical solution in the chamber and a second electrode connecting to the electrically conductive edge of the structure.", "It is thus a feature of at least one embodiment of the invention to provide continuous or semi continuous manufacture of nanowires or microwires and wire shapes while avoiding the need for drum-shaped template, thus permitting manufacture of the template using standard integrated surface substrates, for example silicon wafers, and integrated circuit processing techniques, such as optical or electron beam lithography.", "The template may be mounted for rotation about a first axis perpendicular to the surface of the template and the transfer element may be a disk rotating about a second axis angled with respect to the first axis, the disk having an edge contacting the surface of the template and following an annular track on the surface of the template concentric about the first axis on the template with mutual rotation of the transfer element and template.", "In one implementation, multiple annular tracks are utilized and a stranded nanowire is formed.", "It is thus a feature of at least one embodiment of the invention to provide a simple of removing nanowires and microwires from the template on a continuous basis and in a manner compatible with cyclic immersions of the template in an electrochemical solution.", "The edge of the disk of the transfer element may be beveled to have a non-perpendicular angle with respect to the second axis.", "It is thus a feature of at least one embodiment of the invention to reduce the sheer and/or strain on the nanowirenanowires and microwires during removal by tipping the transfer wheel axis toward the axis of the template.", "The apparatus may include a drum rotating about a third axis and providing an adhesive surface and mounted for movement with respect to transfer element to pull wires off of the transfer element with rotating contact between the drum and transfer element.", "It is thus a feature of at least one embodiment of the invention to permit the transfer of arbitrarily long continuous wires from a finite sized template.", "The drum may translate along the third axis with respect to the transfer element and spool a wire received from the transfer element in a helical coil along a surface of the drum.", "It is thus a feature of at least one embodiment of the invention to provide an orderly winding of extremely long micro-wire or nanowire and to reduce damage thereto.", "The predefined pattern of the electrically conductive edge may define at least one substantially continuous circle on the planar template centered about the axis.", "It is thus a feature of at least one embodiment of the invention to permit a single wire to be formed by multiple rotations of the template through an electrochemical bath.", "By forming the wire along a continuous radius it may be removed tangentially with minimal bending.", "The apparatus may include second chamber for holding a releasing liquid and positioned to admit a portion of the transfer element to move through the releasing liquid with rotation of the transfer element about the second axis.", "In one implementation, the liquid aids in removal of the wire by replacing the wire polymer cohesive force with a liquid-polymer interaction that is stronger.", "It is thus a feature of at least one embodiment of the invention to provide a mechanism for releasing nanowires and microwires from an adhesive transfer element to allow the adhesive transfer element to be reused on a continuous or semi continuous basis.", "The second chamber may include an agitation element for agitating the releasing liquid.", "It is thus a feature of at least one embodiment of the invention to provide for the release of microwires or nanowires with reduced distortion and mechanical damage.", "The template may be mounted for rotation about a first axis perpendicular to the surface of the template.", "It is thus a feature of at least one embodiment of the invention to provide a simple method of cyclically immersing the template in an electrochemical solution as is required for continuous or semi continuous processing.", "The chamber may open upward to admit a portion of the template during rotation of the template with the surface of the template extending vertically.", "It is thus a feature of at least one embodiment of the invention to provide a simple method of providing different zones on the surface of the template allowing for both exposure of the template to electrochemical solution and a drying of the template in a cyclic fashion.", "The predefined pattern of the electrically conductive edge may alternately define multiple discontinuous elements positioned over the surface of the template.", "It is thus a feature of at least one embodiment of the invention to provide a similar mechanism for producing small wire shapes.", "In one embodiment the transfer element may be a flexible tape having an adhesive surface and pressed against a surface of the template by a guide to follow an annular track on the surface of the template concentric about the first axis on the template with rotation of the template.", "It is thus a feature of at least one embodiment of the invention to provide a transfer of small wire shapes to a carrier for later use or placement.", "The apparatus may include an electronic computer executing a stored program controlling operation of the apparatus selected from the group consisting of: (a) a rate of rotation of the substrate through the electrochemical solution; (b) an applied voltage across the electrodes; and (c) the composition of the electrochemical solution.", "It is thus a feature of at least one embodiment of the invention to provide a mechanism that may precisely controlled processing conditions, for example, through feedback or preprogram schedules for improved manufacturing efficiency or research.", "The electrically conductive edge on the planar template may be at an obtuse angle with respect to the substrate.", "It is thus a feature of at least one embodiment of the invention to provide for improved removal of electrochemically formed wires on the edge by tipping the edge in the direction of removal.", "These particular features and advantages may apply to only some embodiments falling within the claims and thus do not define the scope of the invention.", "Additional features, advantages, and embodiments of the present disclosure may be set forth from consideration of the following detailed description, drawings, and claims.", "Moreover, it is to be understood that both the foregoing summary of the present disclosure and the following detailed description are exemplary and intended to provide further explanation without further limiting the scope of the present disclosure claimed.", "BRIEF DESCRIPTION OF THE DRAWINGS The foregoing and other objects, aspects, features, and advantages of the disclosure will become more apparent and better understood by referring to the following description taken in conjunction with the accompanying drawings, in which: FIGS.", "1a and 1b are a fragmentary, perspective, cross-sectional views of an ultranano crystalline diamond (UNCD) template used to grow to small-scale wires by electro-deposition per the present invention before and after the electrode deposition; FIGS.", "2a-2e are elevational views of a cross-section of FIG.", "2 at multiple stages of a transfer process moving the fabricated wires to a second substrate to be combined with other fabricated wires in a complex pattern; FIG.", "3 is a top plan view of possible complex patterns that may be created by the process of FIG.", "2; FIG.", "4 is a Fig.", "similar to that of FIG.", "2 showing a multilayer UNCD pattern having electrically independent conductors for electrodeposition; FIG.", "5 is a Fig.", "similar to that of FIG.", "3 showing a face of the multilayer UNCD pattern used to grow a heterogeneous wire, for example for an electrical device; FIG.", "6 is a perspective view of a tungsten wire produced per the present invention and subsequently treated to be coated with diamond; FIG.", "7 is a perspective view of a cutting tool assembled of bundled wires of the type shown in FIG.", "5; FIG.", "8 is a fragmentary perspective view of a cutting tool showing nanostructures embedded in a cutting tool matrix; FIG.", "9 is a fragmentary cross-section of the matrix material of a cutting tool abraded from around a wire showing the self-sharpening features anticipated in the inventive composite materials; FIG.", "10 is a simplified depiction of a continuous manufacturing process using the technique of the present invention to create nanostructures on a rotating drum and extract them using a tape reel; FIG.", "11 is a perspective fragmentary view of the surface of the rotating cylinder of FIG.", "10 having a pattern to form nanostructure loops of non-convex polygons; FIG.", "12 is a cross-section along line 12-12 of FIG.", "11 showing a conductive via system electrically joining the patterns of FIG.", "11; FIG.", "13 is a perspective view of a solar cell constructed using principles of the present invention using UNCD; FIG.", "14 of the top plan detailed view of the solar cell of FIG.", "13 showing a spacing of holes having deposited photoelectrically active materials; FIG.", "15 is a cross-sectional view along line 15-15 of FIG.", "14; FIG.", "16 is a depiction of microwires in the outline of loops produced by the present invention in the process of being stripped off of the pattern; FIG.", "17 is a depiction similar to that of FIG.", "16 showing microwires in the outline of stars; FIG.", "18 is a perspective view of a planar template for making micro or nanowires showing parts of a mechanism employing that template; FIG.", "19 is a top plan view of the template of FIG.", "18 together with a transfer element removing wire forms from the template for transfer to an adjacent drum; FIG.", "20 is a simplified block diagram of the template, transfer element, and drum as integrated into a manufacturing system including computer control of the planar template, the transfer, the drum and showing electrical and fluid control systems; FIG.", "21 is a simplified diagrammatic representation of the interaction between the planar template, the transfer element, and the drum in the processing and removal of elements formed of nanowires or microwires; FIG.", "22a is a figure similar to FIG.", "2a showing the application of a soft photoresist to an insulating and conductive layer formed on the template of the present invention prior to etching to produce a conductive edge; FIG.", "22b is a figure similar to FIG.", "22a showing a sloped edge of the insulating and conductive layers caused by the erosion of the photoresist during the etching process; FIG.", "23 is a figure similar to FIG.", "22 showing the orientation of a micro-wire or nanowire grown on an exposed edge of the conductor and removal forces when removed using an adhesive and; FIG.", "24 is a fragmentary view of an apparatus similar to that of FIG.", "18 showing the use of an adhesive tape rather than an adhesive transfer wheel to remove microwires or nanowires from the planar substrate.", "DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS In the following detailed description, reference is made to the accompanying drawings, which form a part hereof.", "In the drawings, similar symbols typically identify similar components, unless context dictates otherwise.", "The illustrative embodiments described in the detailed description, drawings, and claims are not meant to be limiting.", "Other embodiments may be utilized, and other changes may be made, without departing from the spirit or scope of the subject matter presented here.", "It will be readily understood that the aspects of the present disclosure, as generally described herein, and illustrated in the figures, can be arranged, substituted, combined, and designed in a wide variety of different configurations, all of which are explicitly contemplated and made part of this disclosure.", "Construction of Small Scale Wires Referring now to FIG.", "1a, the present invention may employ a generally planar substrate 10, for example, a silicon wafer having an upper insulating surface of silicon dioxide, or sapphire, or quartz wafer.", "A conductive layer 12 of ultranano crystalline diamond (UNCD) may be formed on the substrate 10 using an intervening layer of tungsten or molybdenum (not shown) plated or sputtered on the surface of the substrate 10.This conductive layer 12 of ultranano crystalline diamond may be a few nanometers thick measured in a direction perpendicular to the plane of the substrate 10.The conductive layer 12 may be patterned using conventional lithography techniques following predefined mask artwork.", "For example, the generation of the patterned conductive layer 12 may, employ photoresist techniques to apply copper (not shown) to the substrate 10 as a negative image of the patterned conductive layer 12.A layer of UNCD may then be applied over the exposed areas of the substrate 10.UNCD growth on copper is poor the UNCD forming on the copper layer may be removed by dissolving the copper in between the patterned conductive layer 12 removed by chemical etching to leave the patterned UNCD of the conductive layer 12.Alternatively, the patterned conductive layer 12 may be patterned by using reactive ion etching or other similar technique.", "Preferably before the removal of the copper, an insulating layer 14, for example, nonconducting UNCD, may be placed over the patterned conductive layer 12 covering its surface and optionally one edge.", "The insulating layer 14 may be insulating by virtue of the lack of doping of the diamond of the layer 14, in contrast, the conductive layer 12 may be conductive (or semi-conductive) through the introduction of a doping material for example boron (forming a p-type semiconductor) or nitrogen (forming an n-type semiconductor) or by surface treatment such as ion implantation with other doping agents.", "The insulating layer 14 generally covers the patterned conductive layer 12 except at the edges of the patterned conductive layer 12 and without overhang of the patterned conductive layer 12 along a direction normal to a surface of the substrate 10 so as to permit later removal of wires without destruction or removal of the insulating layer 14.Alternatively, complete layers of doped diamond (forming conductive layer 12) and undoped diamond (forming insulating layer 14) may be grown on a substrate 10 which can be coated with a patterned layer of nickel, Si02, or other material which resists reactive ion etching.", "Thus where no layer of nickel or other material exists, both layers of diamond are removed creating an exposed edge of the conductive layer 12 which may be used as an electrode.", "Referring now to FIG.", "1b, a voltage source 17 may be connected to the conductive layer 12 to grow, by electrodeposition, a wire 16 at the exposed step edge of the patterned conductive layer 12.In one embodiment, the wire 16 may be tungsten which is catalytic to diamond but other materials may also be used.", "The size of the wire 16 is determined by the thickness of the patterned conductive layer 12 and the duration of the growing process and thus may be easily controlled to nanoscale dimensions.", "An optional super filling plating bath per T. Moffat, et al.", "Electrochem.", "and Solid-State Lett., 5, 110 (2002) may be used to give even more growth to the wires.", "Further, after fabrication on the substrate 10 as described above, the wires 16 may be extended or joined by chemical vapor deposition processes to make insulators, semiconductors, metals, and alloys.", "The size of the wire 16 may be much smaller than the dimensions of the patterned conductive layer 12 allowing the latter to be produced by conventional lithography techniques that could not be used to directly produce the wire 16.In this way, for example, micron scale photolithography can be used to control nanoscale wires per Penner described above.", "However, the present technique permits reuse of the pattern both by eliminating the overhanging resist layer and through the use of a resilient (non-sacrificial) pattern material.", "The ultrananocrystalline diamond has a number of desirable features for this application as a pattern material.", "It has sufficient conductivity for acting as an electrode when doped and sufficient resistance when undoped to provide an insulator.", "It provides continuous high nucleation density, is robust against hydrogen and high temperatures, and has a large electrochemical window.", "Its strength and adhesion properties allow it to be used repeatedly with the removal of the wires 16.Example 1 It is believed that template of the substrate 10 conductive layer 12 and insulating layer 14, produced as described, can be placed in a bath of 5 millimolar sodium tungstate solution with the conductive layer 12 biased at −1.11 volts with respect to the surrounding solution using an electrode in contact with the solution.", "The voltage may be applied in short pulses according to constant voltage “stop run chronoamperometry” techniques.", "The wires can then be reduced in a reduction atmosphere of hydrogen heated to 500 degrees Celsius to produce a pure metal.", "Wires having a thickness of substantially 10 nm and thousands of nanometers in length have been produced in this fashion using highly oriented pyrolytic graphite instead of UNCD.", "To date this technique has been used to successfully produce wires from cobalt (using an ionic liquid), copper, tellurium, lead, and gold, zinc, platinum, palladium, cadmium, cadmium telluride, cadmium sulfide and zinc sulfide.", "It is anticipated that this technique may be used for depositing nanowires of any material that is capable of being electrodeposited.", "With the proven ability to utilize ionic liquids, refractory metals such as Ti, Nb, Zr, Ta and reactive metals such as Li, Na, K, Rb, Mg, Ca, and Al and intrinsic semiconductors such as Si Ge are expected to be possible.", "In addition most any binary, ternary or more complex materials such as III-V and II-VI semiconductors and superconductors should be capable of being electrodeposited.", "Transfer of Wires Referring now to FIG.", "2a, after production of the wires 16, a transfer material 18 may be applied to the substrate 10 (to cover the insulating layer 14, the patterned conductive layer 12 and the wires 16).", "This transfer material 18 may, for example, be a highly flowable polymer material such as PDMS, cyanoacrylate, polystyrene, epoxies, glue, tape or other material that may be used to adhere to the wire 16, including for example, formed-in-place ice.", "The transfer material 18 may flow under the wire 16 as indicated by arrow 19 to better remove the wire 16 as will be described.", "This underflow can be increased by placing the patterned layer on a pedestal (not shown) for example of insulator such as UNCD.", "The transfer material 18 may then be pulled away from the substrate 10 as shown in FIG.", "2b pulling the wire 16 away from the patterned conductive layer 12 by means of a relatively greater cohesive force between the transfer material 18 and the wires 16 than between the wires 16 and the patterned conductive layer 12.FIGS.", "15 and 16 show wires 16 being removed from a substrate 12 using First Contact™ polymer commercially available from Photonic Cleaning Technologies of Platteville, Wis. USA.", "At this point, the transfer process may be complete and the transfer material 18 may serve as the substrate on which the wires 16 will be used.", "Alternatively however, as shown in FIG.", "2c, the wires 16, as held by the transfer material 18, may then be placed against a second substrate 22 and retained on that second substrate 22 as the transfer material 18 is removed.", "This can be done in many ways, for example, by ensuring a greater cohesive force between the wires 16 and the second substrate 22 than between the wires 16 and the transfer material 18.This condition may be promoted by pretreating the second substrate 22 with an adhesive material or adhering the wires 16 to the second substrate 22 through pressure or heating or the like.", "Or the adhesive quality of the transfer material 18 may be decreased, for example, by flexure shear or melting.", "Alternatively, the transfer material 18 may be dissolved or eroded after the wires 16 are in place.", "Subsequently as shown in FIG.", "2d, an optional second set of wires 16′ may be placed in a different orientation on top of the wires 16, for example, to provide electrical interconnections between wires 16, 16′.", "As will be described further below, through the use of the second UNCD electrode positions near the conductive layer 12 but isolated electrically therefrom, portions of the wires 16 and wire 16′ may be coated with second and third materials that when connected together provide a heterojunction or the like, or the wires 16 and wire 16′ may be grown from different materials or differently treated to provide electrically active junctions.", "Referring now to FIG.", "3, this transfer process allows ESED techniques to produce complex arrays of wires 16, such as by combining a wire bridging element 24 extending between two parallel wires 16 or a grid 26 of crossing wires 16 or convoluted wire 28 such as might be used to create electrode sensors or electrical devices.", "The loop ends of the grid 26 of the convoluted wire 28 may be cut or etched away if separate conductors are desired.", "Electrical Devices Referring now to FIG.", "4, the patterned conductive layer 12 for creating the wires 16 may be quite complicated including, for example, a layer 32 of conductive UNCD presenting an edge 31 for growing a wire where the conductive layer 32 is broken by an insulating portion 34 defining a gap 35.This layer 32 may coated with an insulating layer 36 also filling the gap 35.The insulating layer 36 may be in turn capped with a second conductive layer 38 positioned over a first portion of the gap 35 and flanked by insulating portions 40 so that the end of the conductive layer 38 is exposed over part of the gap 35 in the edge 31.A third conductive layer 44 may be positioned above the second conductive layer 38 so that conductive layer 44 is exposed over a different portion of gap 35 than conductive layer 38.Conductive layer 44 is flanked by insulation 46.Each of the conductive layers 32, 38, and 44 may be electrically isolated from each other but, along the dimension of the edge, may form a nearly continuous conductive path.", "Each of these conductive layers 32, 38, and 44 may be separately connected to an electrical power source 50 to allow for separate electrochemical deposition at the particular conductive layers 32, 38, and 44.Referring now to FIG.", "5, this process of selective activation of each of the conductive layers 32, 38, and 44 may be used to first grow a wire 16 (for example tungsten) at the edge of conductive layer 32 on either side of the gap 35.Next, a first junction element 52 of a different material (for example tungsten doped with a different material or a doped semiconductor or the like) may be grown on the exposed edge of layer 38 at one end of the gap 35 connected to one wire 16, and a second junction element 54 (also of a different material) may be grown at the exposed edge of layer 44 joined with junction element 52 and a second portion of the wire 16.Possible materials for first junction element 52 and the second junction element 54 include CdS, CdSe, CdTe, Al, CuO, ZnS, ZnSe, as well as others.", "The second junction element 54 may be grown until it touches the first junction element 52 as detected by a change in the observed voltage at electrode at conductive layer 38.The two different junction elements 52 and 54 may also be dissimilar metals providing a thermocouple junction providing low mass, high response rate thermocouples.", "Alternatively, the junction elements 52 and 54 may be the same material applied at different times and subject to different doping conditions or maybe implemented by different materials of the wires 16 themselves.", "The heterojunction formed can be a photocell, a PN junction, a thermocouple, or other heterojunction of types known in the art.", "In this way, a heterogeneous wire 56 may be formed so that electricity may flow through a first portion of the wire 16 to junction element 52 and then to a second junction element 54 and then to a second portion of the wire.", "Wires as Substrates for Diamond Referring now to FIG.", "6, more generally, the present invention may be used to create a wires 70 that may be used alone or (in the case of molybdenum or tungsten for example) as a substrate to grow a surrounding super hard material such as crystalline diamond layer 72 by supersaturation of carbon into the tungsten or molybdenum wire that is exuded as a crystalline diamond to create a clad wire 74.The tungsten wire 70 may then be removed by chemical processes to create crystalline diamond wires or left in place to provide a better interface for metallurgical bonding.", "Typically the diamond will not completely surround the wire as shown but will coat only one side when the process is conducted with the wire supported on its side.", "The clad wire 74 may be used, for example, as an electrical conductor with an insulator along its length, for example, to provide for an insulated microelectrode usable in medicine or the like.", "Nanostructure Composites Referring to FIG.", "7, a set of these wires 74 may be sintered with metal particles into a cutting tool 80 optionally with an alignment to impart a directional hardness.", "The diamond coating is shown surrounding a wire core, but more typically only an upper surface of the wire will have a diamond coating when the wires are treated on one surface.", "The diamond outer claddings can be joined with Co, V, Fe, Ti, Nb or other transition metals, the latter which provide a binding matrix portion offering a ductility similar to a polymer with fiberglass.", "More generally, wires 74 may be combined with metal particles in metal injection molding techniques (MIM) in which particles coated with polymer are injection molded into complex shapes, the binding polymer removed and the metal particles sintered around the nanostructures.", "The injection molding techniques, in one embodiment, aid in aligning the elongated forms.", "In these cases, both the metal particles and wires may be coated with a binder and only the metal particles may be coated with a binder.", "In another embodiment, magnetized wires may be encapsulated into hollow polymer spheres similar to those aiding in drug delivery.", "The spheres along with metal particles may be packed into molds.", "Subjected to a strong magnetic field the wires which are loose within the sphere would align prior to removal of polymer spheres through the sintering process.", "Referring also to FIG.", "8, for the purpose of producing cutting tools but also for other composite materials, the wires 74 may be in the form of loops which better anchor the wires within the matrix material 82 particularly when they are partially exposed during abrasion of the tool.", "A similar effect may be obtained by patterning kinks in the wires 74.Referring to FIG.", "9, the extremely hard outer diamond layer 84 of the wires 74 may provide a natural “cat's claw” self-sharpening effect in which the matrix material 82 providing supporting resilience erodes preferentially around the diamond layer 84 to produce a nanoscale sharpened edge.", "The high thermal conductivity of diamond may also provide for assistance in preserving the cutting tool edge, beyond the effect of the hardness of the diamond or other superhard material.", "In one embodiment, ReB2 is utilized as an overcoating over the wires or diamond coated wires.", "The use of the diamond wires 74 need not be limited to this cutting tool but these wires may be used as a component for other types of powdered metallurgy or may be used to create composites in the manner analogous to fiberglass/polymer composites with the diamond wires distributed within a matrix of sintered materials or polymers or other matrices.", "Diamond wires are heat resistant and have high thermal conductivity (four times that of copper) and so may be used in material applications requiring high temperature resistance or conductivity.", "High thermal transfer may help produce fire resistant materials.", "Diamond wires may also be useful for materials that must be scratch resistant.", "Diamond wires may be useful to alter the electrical characteristics of materials or to create sensors.", "Mass Production of Nanostructures Referring now to FIG.", "10, mass production of the nanostructures for the above purposes, for example, may be done using a rotating cylinder 88 providing a template as described above exposed on the outer circumference of the cylinder.", "Referring to FIG.", "11, the outer surface of the cylinder, for example, may have multiple isolated islands 92, exposing edge layers 12 following an outline of non-convex polygons.", "Roughly, 1010 identical 500 nm rings or ovals or other shapes can be manufactured on a 4-inch area.", "And because the pattern is not consumed in this process mass production of nanostructures is rendered practical.", "The edge layers 12 may be covered with non-overhanging insulating layers 14 of common dimension and placed on a second insulating layer 94 (for example non-doped UNCD) providing a planar substrate over top of a conductive layer 96.As shown in FIG.", "12, a conductive via 98 may pass upward from the conductive layer 96 through the insulating layer 94 to conductive layer 12 of each of the islands 92 to provide common electrical connection permitting the growth of loops around the islands 92.The conductive layer 96 may be connected to a biasing electrical power source 50 by means of a slip ring or other similar system.", "The cylinder 88 may be rotated by a motor (not shown) through a bath 91 of electrochemical solution providing material of the nanostructures so that they form on its outer surface as the cylinder 88 during the time a portion of the cylinder 88 is immersed.", "An adhesive material such as adhesive tape 90 may be applied to the exposed portion of the cylinder 88 after the nanostructures are grown to remove the nanostructures.", "The nanostructures may be removed from the tape by a variety of means including a solvent bath acting on the adhesive, mechanical scraping, or burning of the tape.", "Improved Solar Cell Referring now to FIG.", "13, the techniques of the present invention may be used to produce an improved solar cell 93 receiving light 95 at an upper planar surface and providing electrical voltage at electrodes 97.With prior methods the nanowires could be difficult to manipulate and utilize, for example by e-beam lithography or other patterning processes.", "Certain embodiments of the described invention provide a integral isolated electrical contact, which aids in utilize the structure.", "Referring also to FIGS.", "14 and 15, the planar upper surface may include a first outer layer of insulating UNCD 100 over top of a conductive layer 102 of UNCD which in turn is separated from a second conductive layer 104 of UNCD by an insulating layer 106 of UNCD.", "The second conductive layer 104 may rest on a final non-conductive layer 108 of UNCD, in turn, resting on a tungsten film 110 placed on top of a substrate 112, for example, a silicon wafer.", "The effect is to provide for two electrically isolated conductive layers 102 and 104 which may connect to the electrodes 97 respectively to conduct electricity from the solar cell 93.Referring specifically to FIG.", "14, the surface of the solar cell 93 may be punctured by a set of spaced holes 114 through the transparent layers 100-110 and separated by unpunctured areas of the transparent layers 100-110.The size 115 of the holes 114 and their spacing 117 may be adjusted to optimize the light collection area versus the electrical generation area of the solar cell as will now be described.", "In one embodiment, the holes may be slots extending across the direction of light conduction to better capture the light, or the holes may be shaped to promote focusing of light reflected off of the edges of the holes onto previous or adjacent holes.", "As shown in FIG.", "15, each of the holes 114 presents inner edges having areas substantially perpendicular to the face of the substrate 112 upon which may be grown photoelectrically active heterojunction materials 116.For example, one material 118 may be cadmium telluride formed in a toroid within hole 114 grown around the exposed conductive layer 102 as described above and the other material 120 cadmium sulfide formed in an adjacent abutting toroid and grown about layer 104.Light 95 entering transparent layers 100-110 is trapped by internal reflection and conducted to the various holes 114 where electrical power is generated at the heterojunctions and extracted through electrodes 97 (which are, in one embodiment, electrically isolated from one another).", "It should be appreciated that present photovoltaics and solar thermal structures fail to utilize the full spectrum of light.", "The most common photovoltaics typically utilize only the light higher in energy than green.", "Solar thermal typically is inefficient at using the higher wavelengths such as green, blue, violet, and UV.", "As described herein, certain embodiments allow for the passage of the less-useful lower energy wavelength light through the photovoltaic to be harnessed by a solar thermal collector.", "The hole may be formed using reactive ion etching that cuts only about halfway through layer 104.This allows the layers 100-104 to be detached from the substrate 112 by a KOH etching of the silicon of the substrate 112, for example.", "The layer 108 may then be removed and replaced with an antireflection layer (not shown) and layers 100-104 placed over a thermal solar panel.", "Long wavelength light may pass through layer 104 or the anti reflective coating currently not shown providing for heating, for example, for a solar thermal (hot water) collector.", "Because the collection area of the heterojunctions between materials 118 and 120 is vertically disposed, the blockage of sunlight is correspondingly reduced.", "This design may be augmented with grown in place wires to provide lower electrical resistivity for the collection of the electrical power.", "This design does not have any metallic conductors that also shade the solar cell.", "This has zero metal contacts that shade the active areas.", "The thin film of diamond provided by layers 100-110 may provide useful spectral separation allowing different heterojunctions to be tuned to different frequency bands.", "Significantly, the diamond also provides a robust outer surface that will not degrade and is resistant to environmental contamination.", "Diamond may provide advantageous thermal conductivity properties with respect to transmitting heat to the substrate 112.Improved Manufacturing Apparatus with Planar Templates Referring now to FIG.", "18, the mass production of nanostructures may be facilitated through the use of a generally planar template 122, for example, providing a flat disc having surface structure 124 providing the insulation-capped conductive edges described above with respect to any of FIGS.", "1-5 and 11-17.Use of a planar template 122 facilitates generation of the necessary surface structure 124 using standard fabrication techniques adapted to planar structures both in the formation of a substrate wafer and in the processing of that wafer using integrated circuit type techniques including optical or electron beam lithography and the like.", "The planar template 122 may be mounted, for example, on a shaft 126 to rotate about a horizontal axis 128 so that a face of the planar template 122 having the surface structure 124 is substantially vertical to be partially received in an upwardly open chamber 130.The chamber 130 may be filled with electrochemical bath 132 for the growing of nanowires and other similar structure on the surface structure 124.In this way, with rotation of the planar template 122 about the axis 128, the surface structure 124 is repeatedly raised from and lowered into the electrochemical bath 132.An electrical connection 133 may be made between the shaft 126 and a conductive layer of the surface structure 124 forming the edges described above, so that a electrical power source 50 may be connected between the conductive layer of the surface structure 124 (through shaft 126) and an electrode 134 in contact with electrochemical bath 132.Current from the electrical power source 50 may thereby drive the electro-deposition of material onto the edges of the surface structure 124.The surface structure 124 may provide for one or more concentric circular edges 136a for the formation of a continuous wire (as will be described below).", "Alternatively the surface structure 124 may provide a set of discrete discontinuous edges 136b for the generation of shapes, for example, as described with respect to FIGS.", "3, 6-9, 11-12, and 16-17 by electrochemical action driven by the voltage provided by the electrical power source 50.Generally the wire structures or other structures will be formed on that portion of the planar template 122 immersed in the electrochemical bath 132 and after such formation the structures will rise out of the solution 132 with rotation of the template 122 for access as will be described.", "Referring now to FIG.", "19 planar template 122 may contact, at its front surface, the edge of a transfer element 138 which in one embodiment may be a disk 140 having a chamfered edge defining a relatively flat section of a cone.", "The disk 140 of the transfer element 138 may be rotatable about an axis 141 centered on the disk 140 and aligned with an axis of the cone defining its edge.", "The axis 141 is angled with respect to axis 128 to align the chamfered edge with the front face of the planar template 122 at a point of contact between the template 122 and the transfer element 138 above the level of the electrochemical bath 132 so that the structure 124 may be substantially dried as will be described below.", "Referring also to FIG.", "21, a chamfered edge of the disk 140 may thus provide a rolling engagement with a peripheral annulus 142 on the surface of the planar template 122 as the two rotate together, the disk 140 driven by a motor 144 and the planar template 122 driven by the disk 140 in contact therewith.", "It will be appreciated that the radial width of the peripheral annulus 142 may be arbitrarily adjusted by increasing or decreasing the thickness of the chamfered edge of the transfer element 138.The chamfered edge of the transfer disk 140 may be coated with an adhesive material to pull wires formed on the surface structure 124 of the planar template 122 from the planar template 122 in the manner described above with respect to FIG.", "10.Preferably the adhesive material will be reusable.", "For example such adhesive materials may be cross-linked polymers in a gel form, for example, as commercially available from Gel-Pak of Hayward, Calif.", "The adhesive material may be selected according to the particular fabrication process at hand in order to provide sufficient attachment forced to separate electrochemically grown wires from the conductive edges of ultrananocrystalline diamond.", "Referring still to FIGS.", "19 and 21, at the area of contact between the planar template 122 and the transfer element 138, fabricated nanostructures on the edges of the surface structure 124 will be removed from the planar template 122 as attached to the surface of the beveled edge of transfer element 138.To facilitate this process, the surface of the template 122 before its contact with the transfer element 138 may be drained by natural drainage and dried by an air knife 146 directed against the rotation of the template 122 to dry and help loosen nanostructures on the structure 124.In one embodiment, a “solvent knife” may be used, i.e.", "keeping the nanowires wet and utilizing a solvent that aids in removal of the salts.", "Referring also to FIG.", "18, discrete nanostructures formed by elements 136b may then be carried by rotation of the transfer element 138 into a second chamber 150 containing a loosening solvent 152 which may release the nanostructures 154 from the surface of the transfer element 138 by solvent action together with mechanical agitation provided, for example, by ultrasonic transducer 156.An air knife 148 may be directed against the direction of rotation of the beveled edge of the transfer element 138 to further help remove the nanostructures 154 and to prevent the solvent 152 from being transferred to the template 122.A circulation system 158 may be provided whereby solvent 152 is recycled through the chamber 150 through a separator element 160, for example, a filter or centrifuge and then returned by pump 162 back to the chamber 150 to provide for essentially continuous extraction of the nanostructures 154.Referring now to FIGS.", "19,20, and 21, alternatively, a continuous wire nano structure formed by edges 136a may be carried by the transfer element 138 over into contact with a drum 164.In this case the second chamber 150 may be empty or removed entirely.", "The drum 164 provides a cylindrical outer surface a generally parallel to the beveled edge of the disk 140 at its point of abutment with the beveled edge of disk 140 removed from its contact with the planar template 122.The drum 164 may rotate about a third axis 165 generally different in angle from axes 141 and 128, necessary to produce this abutment.", "By the intra-engagement of the planar template 122, the transfer element 138, and the drum 164, a wire 166 formed by edge 136a may be transferred continuously with little distortion, stretching, strain or tension to the outer cylindrical surface of the drum 164.It is necessary only that the outer surface of the drum provides an adhesive material whose tack is relatively stronger in retaining the wire 166 then the adhesive on the surface of the beveled edge of the transfer element 138.In one embodiment, the drum 164 may be coated with a wax or thermoplastic adhesive material that is softened at a point 170 immediately before contact with the transfer element 138, for example, by a laser 173, to increase the stickiness of the wax so as to effect the transfer of the wire 166 from the transfer element 138 to the drum 164.Referring now to FIG.", "20, the planar template 122 and transfer element 138 may be mounted on a movable carriage 172, for example, sliding along a way 175 under the control of a motor drive 174.The sliding of the carriage 172 may be synchronized with rotation of the drum 164 about axis 165 so as to spool the continuous wire 166 in the helical path around the outer surface of the drum 164.The pitch of that helical path is greatly exaggerated in FIG.", "20 and will generally be quite fine so as to allow a considerable length of wire 166 to be collected on the drum 164, for example, a kilometer or more.", "A motor 176 rotating the drum 164 may be under the control of a computer 178 which also communicates with the drive 174 to provide the desired winding pitch.", "The computer generally will include a processor 180 communicating with a memory 182 holding a stored program 184 to provide the control described herein.", "The computer 178 may also control the electrical power source 50, for example, with respect to duty cycle, on and off time, current flow, and voltage and may further control a fluid handling system 185 comprised of one or more reservoirs 186 of different electrochemical solutions and solvents that may be metered through metering valves 188 and pump 190 into chamber 130.Each of the valves 188 and pump 190 as controlled by the computer 178 may provide for predetermined schedules of applied voltage, rotational speed of the template 122, and electrochemical composition of the bath 132 during this process.", "Referring momentarily to FIG.", "24, it will be appreciated that the features described above with respect to FIG.", "10 may be combined with the planar template 122 to provide, for example, an adhesive tape 90, for example, having adhesive on the flexible backer material such as paper or plastic that may pass over a roller 189 positioned to press an adhesive surface of the tape 90 into a rolling contact with the front surface of the planar template 122 to sweep out an annular area 142 over which either a wire formed on edge 136a or discrete components faulted on surfaces are edges 136b (shown in FIG.", "1) will be removed.", "In this way the benefits of the planar template 122 may be combined with those of the tape 90.Template with Angled Face Referring now to FIG.", "22a in the fabrication of any of the insulation-capped conductive edges described above with respect to any of FIGS.", "1-5 and 11-17, the conductive layer 12 and insulating layer 14 maybe capped with a “soft” resist layer 192 in contrast, for example, to a metal layer.", "The soft resist layer 192 may be a standard photo resist polymer material of a type having a tendency to erode during the etching process used to remove the insulating layer 14 and conductive layer 12 to produce the desired edges.", "Referring now to FIG.", "22b, the process of erosion of the resist layer 192 during etching, indicated by arrow 196, causes the exposed edges 198 of the conductive layer 12 to be sloping at an angle with respect to the surface normal of the substrate 12.This sloping, which is in the opposite direction of the undercutting that might be provided by a more robust mask in place of the resist layer 192, provides a substantial horizontal component to the surface of the edges 198.Referring now to FIG.", "23, a wire 16 grown on the conductive layer 12 at the exposed edge 198 may thus better contact an adhesive interface 200, for example, from the transfer element 138 described with respect to FIG.", "21 or the adhesive tape 90 of FIG.", "10.This better contact in turn may provide greater removal force.", "In addition, the removal force indicated by arrow 202, being generally normal to the surface of the substrate 10, will have a substantial tension component 204 perpendicular to the exposed surface 198 in addition to the perpendicular shear component 206 along the surface 198 that may assist in removal of the wire 16.Generally the angle of the exposed edge 198 with respect to the exposed surface of the substrate 10 will be obtuse or greater than 90 degrees and may be greater than 135 degrees.", "In one embodiment, the sloped edge of the insulating and conducting layers selected from convex, planar, and concave.", "The sloped edge may be convex if the photoresist is more resistant than the diamond.", "“Wire” as used herein refers generally both to free lengths of wire and wireforms made of wire having distinct ends or formed in a loop.", "“Adhesive” as used herein means any material that tends to attach or to releasably attach to another material in the manner of an adhesive includes materials that may not be termed adhesives, adhesives, cohesive and the like.", "“Adhesive” includes materials that go through a phase change, such as frozen water, as well as lock and key type adhesion.", "“Nanowire” as used herein means a wire with a cross-sectional area less than 1000 μm2 and more typically a dimension of less than 100 nm in cross-section and with a length of at least 10 times its cross-sectional dimension and typically more than 1000 nm long.", "“Microwire” as used herein means a wire with a cross-sectional area less than 1000 μm2 and more typically a dimension of less than 100 μm in cross-section and with a length of at least 10 times its cross-sectional dimension and typically more than 1000μm long.", "“Conductive” and “conductor” are intended to cover materials that are noninsulating as that term is generally understood and therefore to include semiconductive materials.", "It is specifically intended that the present invention not be limited to the embodiments and illustrations contained herein, but include modified forms of those embodiments including portions of the embodiments and combinations of elements of different embodiments as come within the scope of the following claims.", "The foregoing description of illustrative embodiments has been presented for purposes of illustration and of description.", "It is not intended to be exhaustive or limiting with respect to the precise form disclosed, and modifications and variations are possible in light of the above teachings or may be acquired from practice of the disclosed embodiments.", "It is intended that the scope of the invention be defined by the claims appended hereto and their equivalents." ] ]
Patent_15872913